PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2515891-0	1989	Common structural changes accompany the functional inactivation of HPr by seryl phosphorylation or by serine to aspartate substitution.	Aspartic Acid	112-121	haptoglobin-related protein	Homo sapiens	67-70
2515891-3	1989	Phosphorylation at Ser46 or a Ser to Asp substitution at this position inactivates HPr [Reizer, J., Sutrina, S. L., Saier, M. H., Stewart, G. C., Peterkofsky, A., & Reddy, P. (1989) EMBO J.	Aspartic Acid	37-40	haptoglobin-related protein	Homo sapiens	83-86
2515891-6	1989	The results demonstrate that the functional inactivation of HPr brought about by the serine to aspartate mutation is accompanied by the same structural changes that occur when HPr is phosphorylated at Ser46.	Aspartic Acid	95-104	haptoglobin-related protein	Homo sapiens	60-63
2600080-5	1989	The COOH-terminal sequence of the high affinity Ca2+-binding protein, Lys-Asp-Glu-Leu, is the same as that proposed to be an endoplasmic reticulum retention signal (Munro, S., and Pelham, H. R. B.	Aspartic Acid	74-77	calreticulin	Oryctolagus cuniculus	34-68
2689438-2	1989	Comparison of all known C-peptide sequences reveals the presence of a highly conserved peptide sequence, Glu/Asp-X-Glu/Asp (X being a hydrophobic amino acid), adjacent to the Arg-Arg doublet at the B chain/C-peptide junction.	Aspartic Acid	109-112	insulin 2	Rattus norvegicus	24-33
2689438-2	1989	Comparison of all known C-peptide sequences reveals the presence of a highly conserved peptide sequence, Glu/Asp-X-Glu/Asp (X being a hydrophobic amino acid), adjacent to the Arg-Arg doublet at the B chain/C-peptide junction.	Aspartic Acid	109-112	insulin 2	Rattus norvegicus	206-215
2573599-2	1989	High resolution 1H nuclear magnetic resonance spectroscopy and optical stopped-flow techniques have been used to study the metal binding properties of a site-specific mutant of bacterial recombinant oncomodulin in which glutamate has replaced a liganding aspartate at position 59 in the CD calcium-binding site.	Aspartic Acid	255-264	oncomodulin	Rattus norvegicus	199-210
2573599-5	1989	This finding supports the original hypothesis that the presence of Asp at sequence position 59 is an important factor in the reduced preference of the CD site of oncomodulin for smaller metals such as magnesium (Williams, T. C., Corson, D. C., Sykes, B. D., and MacManus, J. P. (1987) J. Biol.	Aspartic Acid	67-70	oncomodulin	Rattus norvegicus	162-173
2573600-6	1989	In contrast, the Arg-Gly-Asp-Ser tetrapeptide as well as the monoclonal antibody 7E3 markedly inhibited attachment of endothelial cells to substrate-immobilized fibrinogen, whereas fragment D or E did not.	Aspartic Acid	25-28	fibrinogen beta chain	Homo sapiens	161-171
2819242-7	1989	The point mutation from an aspartic acid (pK for the beta-carboxyl = 3.86) to a tyrosine (pK for the aromatic hydroxyl = 10.07) may have perturbed the folding gamma chain structure in the D domain of fibrinogen specifically required for polymerization.	Aspartic Acid	27-40	fibrinogen beta chain	Homo sapiens	200-210
2685120-4	1989	In contrast, lymphokine-mediated agglutination involves interactions between the MAggF cell-binding domain and integrin FN receptors recognizing the Arg-Gly-Asp sequence.	Aspartic Acid	157-160	interleukin 2	Homo sapiens	13-23
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Aspartic Acid	20-23	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	42-46
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Aspartic Acid	20-23	fibronectin 1	Rattus norvegicus	62-73
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Aspartic Acid	20-23	vitronectin	Rattus norvegicus	78-89
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Aspartic Acid	20-23	thyrotropin releasing hormone	Rattus norvegicus	120-123
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Aspartic Acid	20-23	fibronectin 1	Rattus norvegicus	186-197
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Aspartic Acid	20-23	vitronectin	Rattus norvegicus	203-214
2572594-1	1989	Replacement of the aspartate residue at position 59 of rat oncomodulin by glutamate by oligonucleotide-directed mutagenesis has afforded a protein which more closely resembles rat parvalbumin, at least judged by its interaction with the luminescent lanthanide ion Eu3+.	Aspartic Acid	19-28	oncomodulin	Rattus norvegicus	59-70
2584723-0	1989	The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha chain of the complement component, C3.	Aspartic Acid	106-115	lysophosphatidylcholine acyltransferase 3	Homo sapiens	29-32
2688744-10	1989	Analysis of the cholesterol esterase structure also revealed a repetitive sequence enriched with Pro, Asp, Glu, Ser, and Thr residues at the C-terminal end of the protein.	Aspartic Acid	102-105	carboxyl ester lipase	Rattus norvegicus	16-36
2572594-9	1989	These findings strongly suggest that residues in oncomodulin besides aspartate 59 are important determinants of the observed calcium specificity of the CD calcium-binding domain.	Aspartic Acid	69-78	oncomodulin	Rattus norvegicus	49-60
2597139-4	1989	In stirred platelets, total and specific inhibition of PMA-induced aggregation by a fibrinogen-derived peptide (RGDS, i.e. Arg-Gly-Asp-Ser) promoted maximal increases in membrane-associated PKC in the presence of PMA and completely prevented the loss in cellular activity.	Aspartic Acid	131-134	ral guanine nucleotide dissociation stimulator	Homo sapiens	112-116
2575005-2	1989	Compared with 1 or 10 mM glucose, superfusion of CA1 slices with 0.1 mM glucose enhanced the K+-evoked release of both glutamate and aspartate, increased the ratio of aspartate release to glutamate release and did not affect the release of GABA.	Aspartic Acid	133-142	carbonic anhydrase 1	Rattus norvegicus	49-52
2633825-1	1989	It has been found out that tripeptide Arg-Gly-Asp being under natural conditions a fibronectin fragment, responsible for adhesion, is capable in vitro to stimulate ingestion ability of the rat blood polymorphonuclear leucocytes and monocytes.	Aspartic Acid	46-49	fibronectin 1	Rattus norvegicus	83-94
2806726-3	1989	In contrast, monoclonal antibodies directed against the collagen- and integrin-binding domains of fibronectin, or oligopeptides containing the fibronectin integrin-recognition sequence arg-gly-asp-ser, had no significant effect on condensation number.	Aspartic Acid	193-196	fibronectin 1	Gallus gallus	143-154
2606746-1	1989	In Caucasoids HLA-DQB1 genes encoding amino acids other than aspartic acid at position 57 of the DQ beta chain (non-Asp-57) are associated with susceptibility to develop insulin-dependent diabetes mellitus (IDDM), while resistance is associated with aspartic acid at this residue (Asp-57).	Aspartic Acid	116-119	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	14-22
2606746-1	1989	In Caucasoids HLA-DQB1 genes encoding amino acids other than aspartic acid at position 57 of the DQ beta chain (non-Asp-57) are associated with susceptibility to develop insulin-dependent diabetes mellitus (IDDM), while resistance is associated with aspartic acid at this residue (Asp-57).	Aspartic Acid	116-119	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	97-104
2606746-1	1989	In Caucasoids HLA-DQB1 genes encoding amino acids other than aspartic acid at position 57 of the DQ beta chain (non-Asp-57) are associated with susceptibility to develop insulin-dependent diabetes mellitus (IDDM), while resistance is associated with aspartic acid at this residue (Asp-57).	Aspartic Acid	250-263	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	14-22
2606746-1	1989	In Caucasoids HLA-DQB1 genes encoding amino acids other than aspartic acid at position 57 of the DQ beta chain (non-Asp-57) are associated with susceptibility to develop insulin-dependent diabetes mellitus (IDDM), while resistance is associated with aspartic acid at this residue (Asp-57).	Aspartic Acid	250-263	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	97-104
2606746-1	1989	In Caucasoids HLA-DQB1 genes encoding amino acids other than aspartic acid at position 57 of the DQ beta chain (non-Asp-57) are associated with susceptibility to develop insulin-dependent diabetes mellitus (IDDM), while resistance is associated with aspartic acid at this residue (Asp-57).	Aspartic Acid	281-284	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	14-22
2606746-1	1989	In Caucasoids HLA-DQB1 genes encoding amino acids other than aspartic acid at position 57 of the DQ beta chain (non-Asp-57) are associated with susceptibility to develop insulin-dependent diabetes mellitus (IDDM), while resistance is associated with aspartic acid at this residue (Asp-57).	Aspartic Acid	281-284	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	97-104
2606746-3	1989	Of these patients 82% carried DQB1 alleles encoding non-Asp-57 at both of their DQ beta chains, compared to 27% of the controls (relative risk = 12.2, p less than 0.0001).	Aspartic Acid	56-59	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	30-34
2808373-4	1989	Because osteopontin mediates cell adhesion and spreading, and contains an Arg-Gly-Asp-Ser cell-binding sequence, our observations strongly suggest that the cell surface localization of pp69 osteopontin is receptor-mediated, and the modification by phosphorylation may be crucial for its receptor binding activity.	Aspartic Acid	82-85	secreted phosphoprotein 1	Rattus norvegicus	190-201
2509263-7	1989	Peptides with the sequence arg-gly-asp-ser or gly-arg-gly-asp-ser, which inhibit adhesive interactions mediated by the integrin-binding domain of fibronectin, had no effect on conveyance or accumulation of heparin-coated beads, but the peptide with the sequence gly-arg-gly, a repeated motif in the amino-terminal heparin-binding domain was completely inhibitory.	Aspartic Acid	35-38	fibronectin 1	Homo sapiens	146-157
2554575-6	1989	Tick-borne and mosquito-borne flaviviruses share a common hydrophilicity profile and also other features of their primary sequences, such as the presumably functional Gly-Asp-Asp sequence element within protein NS5.	Aspartic Acid	171-174	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	211-214
2554575-6	1989	Tick-borne and mosquito-borne flaviviruses share a common hydrophilicity profile and also other features of their primary sequences, such as the presumably functional Gly-Asp-Asp sequence element within protein NS5.	Aspartic Acid	175-178	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	211-214
2575005-2	1989	Compared with 1 or 10 mM glucose, superfusion of CA1 slices with 0.1 mM glucose enhanced the K+-evoked release of both glutamate and aspartate, increased the ratio of aspartate release to glutamate release and did not affect the release of GABA.	Aspartic Acid	167-176	carbonic anhydrase 1	Rattus norvegicus	49-52
2575005-3	1989	With both high and low glucose concentrations, the K+-evoked release of glutamate and aspartate originated predominantly from a Ca2+-sensitive store associated with the SCCIA projection.	Aspartic Acid	86-95	carbonic anhydrase 2	Rattus norvegicus	128-131
2575005-10	1989	Enhanced aspartate release may be particularly relevant to hypoglycemic damage in the CA1 area, because aspartate is a more potent hippocampal excitotoxin than glutamate.	Aspartic Acid	9-18	carbonic anhydrase 1	Rattus norvegicus	86-89
2575005-10	1989	Enhanced aspartate release may be particularly relevant to hypoglycemic damage in the CA1 area, because aspartate is a more potent hippocampal excitotoxin than glutamate.	Aspartic Acid	104-113	carbonic anhydrase 1	Rattus norvegicus	86-89
2506185-6	1989	The zymogen with no proteinase activity due to a mutation at the active site residue, Asp, was still processed at a relatively slower rate in a wild-type strain of yeast, but no processing occurred in the pep4-3 mutant strain of S. cerevisiae deficient in yeast proteinase A.	Aspartic Acid	86-89	proteinase A	Saccharomyces cerevisiae S288C	262-274
2477372-11	1989	The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer.	Aspartic Acid	201-204	epidermal growth factor receptor	Homo sapiens	39-51
2477372-11	1989	The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer.	Aspartic Acid	201-204	epidermal growth factor	Mus musculus	39-42
2477372-11	1989	The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer.	Aspartic Acid	201-204	epidermal growth factor receptor	Homo sapiens	121-133
2477372-12	1989	The mutually competitive binding of EGF and antibodies LA22, LA58, and LA90 implied that the amino acids between Ala-351 and Asp-364 participated in the formation of the EGF-binding site of the human EGF receptor.	Aspartic Acid	125-128	epidermal growth factor	Homo sapiens	36-39
2477372-12	1989	The mutually competitive binding of EGF and antibodies LA22, LA58, and LA90 implied that the amino acids between Ala-351 and Asp-364 participated in the formation of the EGF-binding site of the human EGF receptor.	Aspartic Acid	125-128	epidermal growth factor	Homo sapiens	170-173
2477372-12	1989	The mutually competitive binding of EGF and antibodies LA22, LA58, and LA90 implied that the amino acids between Ala-351 and Asp-364 participated in the formation of the EGF-binding site of the human EGF receptor.	Aspartic Acid	125-128	epidermal growth factor receptor	Homo sapiens	200-212
2529542-6	1989	Furthermore, the murine Fc epsilon RII is truncated at the carboxyl terminus and the Arg-Gly-Asp sequence, a common recognition site of integrin receptors, which is found in the reverse configuration in human Fc epsilon RII, is missing.	Aspartic Acid	93-96	Fc epsilon receptor II	Homo sapiens	209-223
2512191-0	1989	Aspartic acid at position 57 of DQ beta chain does not protect against type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.	Aspartic Acid	0-13	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	32-39
2512191-6	1989	These data indicate that the protective role of aspartic acid at position 57 of DQ beta chain is less significant in Japanese compared with Caucasian subjects.	Aspartic Acid	48-61	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	80-87
2529542-6	1989	Furthermore, the murine Fc epsilon RII is truncated at the carboxyl terminus and the Arg-Gly-Asp sequence, a common recognition site of integrin receptors, which is found in the reverse configuration in human Fc epsilon RII, is missing.	Aspartic Acid	93-96	Fc receptor, IgE, low affinity II, alpha polypeptide	Mus musculus	24-38
2550440-5	1989	A full length human ral cDNA was isolated from a placental cDNA library, and its deduced amino acid sequence, compared with simian ral, also contained the Asp----Glu substitution along with two other substitutions and an additional three NH2-terminal amino acids.	Aspartic Acid	155-158	RAS like proto-oncogene A	Homo sapiens	20-23
2489330-2	1989	Significantly higher correlation (coefficient of correlation = 0.922) was found between ASP and IAP.	Aspartic Acid	88-91	islet amyloid polypeptide	Homo sapiens	96-99
2552437-5	1989	In contrast, the KRAS protein, which carries an extremely basic domain (residues 172-182, Lys-Asp-Glu-Lys6-Ser-Arg), is phosphorylated by the receptor kinase without the addition of basic proteins.	Aspartic Acid	94-97	KRAS proto-oncogene, GTPase	Homo sapiens	17-21
2514788-6	1989	Furthermore, P-450mt3 shows an N-terminal amino acid sequence (Ala-Ile-Pro-Ala-Ala-Leu-Arg-Thr-Asp) different from those of both P-450mt1 and P-450mt2, as well as microsomal P-450b.	Aspartic Acid	95-98	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	174-180
2617513-1	1989	DQw8 (DQw3.2) on DR4 haplotypes is a susceptibility gene for development of insulin-dependent diabetes mellitus (IDDM) in Caucasoids, possibly because it encodes a non-Asp amino acid (aa) (i.e. Ala) at residue 57 of the DQ beta chain (non-Asp-57).	Aspartic Acid	168-171	major histocompatibility complex, class II, DR beta 4	Homo sapiens	17-20
2617513-6	1989	The DQB1 genes on their DR4 and DRw9 haplotypes in all cases encoded Asp-57.	Aspartic Acid	69-72	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-8
2617513-6	1989	The DQB1 genes on their DR4 and DRw9 haplotypes in all cases encoded Asp-57.	Aspartic Acid	69-72	major histocompatibility complex, class II, DR beta 4	Homo sapiens	24-27
2777770-2	1989	The complete primary structure of the type I isoform of bovine brain PIMT was determined by sequence analysis of peptides generated by endoprotease Lys-C, trypsin, cyanogen bromide, and endoprotease Asp-N digests.	Aspartic Acid	199-202	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Bos taurus	69-73
2550426-7	1989	We have now constructed a human insulin receptor mutant in which 3 residues in this sequence were altered (Thr-Cys-Pro-Pro-Pro-Tyr-Tyr-His-Phe-Gln-Asp to Thr-Cys-Pro-Arg-Arg-Tyr-Tyr-Asp-Phe-Gln-Asp) and have expressed this mutant in rat hepatoma (HTC) cells.	Aspartic Acid	147-150	insulin receptor	Homo sapiens	32-48
2550426-7	1989	We have now constructed a human insulin receptor mutant in which 3 residues in this sequence were altered (Thr-Cys-Pro-Pro-Pro-Tyr-Tyr-His-Phe-Gln-Asp to Thr-Cys-Pro-Arg-Arg-Tyr-Tyr-Asp-Phe-Gln-Asp) and have expressed this mutant in rat hepatoma (HTC) cells.	Aspartic Acid	182-185	insulin receptor	Homo sapiens	32-48
2550426-7	1989	We have now constructed a human insulin receptor mutant in which 3 residues in this sequence were altered (Thr-Cys-Pro-Pro-Pro-Tyr-Tyr-His-Phe-Gln-Asp to Thr-Cys-Pro-Arg-Arg-Tyr-Tyr-Asp-Phe-Gln-Asp) and have expressed this mutant in rat hepatoma (HTC) cells.	Aspartic Acid	182-185	insulin receptor	Homo sapiens	32-48
2673537-3	1989	Endothelial cells exclusively recognize an Arg-Gly-Asp-containing site near the C-terminus of the alpha chain (alpha residues 572-574) but fail to recognize the Arg-Gly-Asp sequence in the N-terminal region of the same chain (alpha residues 95-97).	Aspartic Acid	51-54	Fc gamma receptor and transporter	Homo sapiens	98-133
2527855-8	1989	Laminin-binding by the alpha beta 1 complex was independent of Arg-Gly-Asp or Tyr-Ile-Gly-Ser-Arg-like sequences, but required the presence of divalent cations.	Aspartic Acid	71-74	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	29-35
2775312-6	1989	Depression of aspartate regeneration by inhibition of pyruvate carboxylase is a likely mechanism for impairment of urea cycle activity by both drugs.	Aspartic Acid	14-23	pyruvate carboxylase	Homo sapiens	54-74
2480135-5	1989	Comparative studies of deduced protein sequences of rat liver EF-2 and hamster EF-2 [1] revealed the only substitution of aspartate residue for glutamate residue (hamster EF-2).	Aspartic Acid	122-131	eukaryotic translation elongation factor 2	Rattus norvegicus	62-66
2480135-5	1989	Comparative studies of deduced protein sequences of rat liver EF-2 and hamster EF-2 [1] revealed the only substitution of aspartate residue for glutamate residue (hamster EF-2).	Aspartic Acid	122-131	eukaryotic translation elongation factor 2	Rattus norvegicus	79-83
2480135-5	1989	Comparative studies of deduced protein sequences of rat liver EF-2 and hamster EF-2 [1] revealed the only substitution of aspartate residue for glutamate residue (hamster EF-2).	Aspartic Acid	122-131	eukaryotic translation elongation factor 2	Rattus norvegicus	79-83
2697983-10	1989	Based on structural and mutational analysis, a model for human prorenin was built that suggests lysine -2 of the prosegment interacts with active site aspartate residues, and that the prosegment inactivation of renin is stabilized by binding of an amino terminal beta strand into a groove on renin.	Aspartic Acid	151-160	renin	Homo sapiens	66-71
2674939-1	1989	A Ca2+ binding site like an EF-hand motif was designed and created in human lysozyme by replacing both Gln-86 and Ala-92 with aspartic acids by site-directed mutagenesis.	Aspartic Acid	126-140	lysozyme	Homo sapiens	76-84
2613766-10	1989	Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors.	Aspartic Acid	75-78	fibrinogen beta chain	Homo sapiens	22-25
2613766-10	1989	Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors.	Aspartic Acid	75-78	ral guanine nucleotide dissociation stimulator	Homo sapiens	84-88
2614645-1	1989	A novel inhibitor of angiotensin-converting enzyme (ACE) derived from tuna muscle, Pro-Thr-His-Ile-Lys-Trp-Gly-Asp (tuna AI), was chemically synthesized, and its biological properties were investigated.	Aspartic Acid	111-114	angiotensin-converting enzyme	Oryctolagus cuniculus	52-55
2681243-0	1989	High-performance liquid chromatographic monitoring of transpeptidation reactions in analogues of gonadotropin releasing hormone containing aspartic acid derivatives in position six.	Aspartic Acid	139-152	gonadotropin releasing hormone 1	Homo sapiens	97-127
2570199-0	1989	HLA-DQ beta non-ASP-57 allele and incidence of diabetes in China and the USA.	Aspartic Acid	16-19	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	0-11
2527238-2	1989	Since both ligands bind to it through their respective RGDS (Arg-Gly-Asp-Ser) domains and since both have been cloned, we were able to deduce the amino acid sequence of the binding site from the nucleotide sequence coding for RGDS in both proteins.	Aspartic Acid	69-72	ral guanine nucleotide dissociation stimulator	Homo sapiens	55-59
2527238-2	1989	Since both ligands bind to it through their respective RGDS (Arg-Gly-Asp-Ser) domains and since both have been cloned, we were able to deduce the amino acid sequence of the binding site from the nucleotide sequence coding for RGDS in both proteins.	Aspartic Acid	69-72	ral guanine nucleotide dissociation stimulator	Homo sapiens	226-230
2681243-1	1989	High-performance liquid chromatographic systems were used for monitoring the hydrolysis of five potent agonistic gonadotropin releasing hormone analogues containing aspartic acid derivatives in position six.	Aspartic Acid	165-178	gonadotropin releasing hormone 1	Homo sapiens	113-143
2473125-0	1989	The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3.	Aspartic Acid	106-115	lysophosphatidylcholine acyltransferase 3	Homo sapiens	29-32
2473125-0	1989	The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3.	Aspartic Acid	106-115	Fc gamma receptor and transporter	Homo sapiens	148-159
2473125-8	1989	The result of this point mutation at the translational level is the substitution of an asparagine residue in C3S for an aspartic acid residue in C3F.	Aspartic Acid	120-133	lysophosphatidylcholine acyltransferase 3	Homo sapiens	145-148
2791302-1	1989	The apparent Km values of argininosuccinate synthase toward citrulline and aspartate were significantly increased in cultured skin fibroblasts from one patient with neonatal citrullinemia, whereas, those determined in cells from three other patients were within the normal range.	Aspartic Acid	75-84	argininosuccinate synthase 1	Homo sapiens	26-52
2804442-4	1989	The molecular weight, 2857.4 and 2858.4, indicated the amino acid substitutions of asparagine and aspartic acid, respectively, for lysine at position 82 of beta globin chain.	Aspartic Acid	98-111	hemoglobin subunit beta	Homo sapiens	156-173
2753902-1	1989	The platelet glycoprotein IIb-IIIa complex (GP IIb-IIIa) is a member of the integrin receptor family that recognizes adhesive proteins containing the Arg-Gly-Asp (RGD) sequence.	Aspartic Acid	158-161	integrin subunit alpha 2b	Homo sapiens	44-50
2489085-1	1989	Anti-cell adhesive activity was examined by the synthetic polypeptide, containing repetitive Arg-Gly-Asp sequence of cell attachment site from fibronectin, poly (Arg-Gly-Asp).	Aspartic Acid	101-104	fibronectin 1	Mus musculus	143-154
2737305-5	1989	Human and bovine nucleolin exhibited more additions and/or substitutions of aspartate, glutamate and serine residues in the chromatin-binding domains by comparison with the hamster and mouse nucleolins.	Aspartic Acid	76-85	nucleolin	Bos taurus	17-26
2736523-1	1989	We investigated that the antimetastatic and antiadhesive activities of peptides based on Arg-Gly-Asp adhesive signal in fibronectin could be augmented by their polymerization.	Aspartic Acid	97-100	fibronectin 1	Mus musculus	120-131
2545728-0	1989	Von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism.	Aspartic Acid	72-75	von Willebrand factor	Homo sapiens	0-21
2545728-13	1989	We found that the antibody that recognizes the residues 1,744-1,746, containing the Arg-Gly-Asp sequence, completely inhibit EC adhesion to vWF whereas a second antibody recognizing the adjacent residues 1,740-1,742 (Arg-Gly-Asp-free) is inactive.	Aspartic Acid	92-95	von Willebrand factor	Homo sapiens	140-143
2545728-15	1989	This defines the molecular domain on vWF that is specifically recognized by ECs and reaffirms the direct role of the Arg-Gly-Asp sequence as the integrin receptor recognition site also in the vWF molecule.	Aspartic Acid	125-128	von Willebrand factor	Homo sapiens	37-40
2545728-15	1989	This defines the molecular domain on vWF that is specifically recognized by ECs and reaffirms the direct role of the Arg-Gly-Asp sequence as the integrin receptor recognition site also in the vWF molecule.	Aspartic Acid	125-128	von Willebrand factor	Homo sapiens	192-195
2666911-3	1989	We report here that three of 15 colon tumors tested contain K-ras codon 12 aspartic acid mutations and one, along with the HCT 116 colon carcinoma cell line, contains a K-ras codon 13 aspartic acid mutation.	Aspartic Acid	184-197	KRAS proto-oncogene, GTPase	Homo sapiens	169-174
2509907-5	1989	Comparisons of the sequences of HSP70 and HSP83 homologues show that these two families of heat-shock proteins are not significantly related except for the last four amino acid residues, which are Glu-Glu-Val-Asp in every case.	Aspartic Acid	209-212	Heat-shock-protein-70Ab	Drosophila melanogaster	32-37
2509907-5	1989	Comparisons of the sequences of HSP70 and HSP83 homologues show that these two families of heat-shock proteins are not significantly related except for the last four amino acid residues, which are Glu-Glu-Val-Asp in every case.	Aspartic Acid	209-212	Heat shock protein 83	Drosophila melanogaster	42-47
2489324-5	1989	There was positive correlation between CEA and IAP, ASP in pancreatic cancer.	Aspartic Acid	52-55	CEA cell adhesion molecule 3	Homo sapiens	39-42
2775751-9	1989	The active site histidine, His-186, is hydrogen bonded from nitrogen ND1 to the carboxylate of Asp-158 and from its nitrogen NE2 to the sulfate ion bound in the putative substrate binding site.	Aspartic Acid	95-98	NADH dehydrogenase subunit 1	Sus scrofa	69-72
2778161-3	1989	Lactophorin and the seven components were rich in aspartic acid, threonine, serine, glutamic acid, leucine, and lysine.	Aspartic Acid	50-63	glycosylation dependent cell adhesion molecule 1	Bos taurus	0-11
2661228-0	1989	Glutamic acid 71 and aspartic acid 66 control the binding of the second calcium ion in porcine pancreatic phospholipase A2.	Aspartic Acid	21-34	phospholipase A2 group IB	Homo sapiens	106-122
2735907-11	1989	Like three other members of the family, FL-NCA-3 contains the Arg-Gly-Asp sequence in a position in the N-domain corresponding to complementarity determining region 3 of immunoglobulin.	Aspartic Acid	70-73	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	40-48
2773809-8	1989	Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Aspartic Acid	126-129	integrin subunit alpha 2b	Homo sapiens	51-56
2736258-6	1989	N-terminal and internal sequences derived from the rat tumor-secreted phosphoprotein indicate that it is identical to rat osteopontin, a bone protein with an Arg-Gly-Asp cell-binding sequence (Oldberg, A., Franzen, A. and Heinegard, D. (1986) Proc.	Aspartic Acid	166-169	secreted phosphoprotein 1	Rattus norvegicus	122-133
2773809-8	1989	Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Aspartic Acid	126-129	fibrinogen beta chain	Homo sapiens	81-91
2773809-8	1989	Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Aspartic Acid	126-129	Fc gamma receptor and transporter	Homo sapiens	141-152
2499045-1	1989	The hydrogen-bonding status of His57 in the catalytic triad (Asp-His-Ser) of serine protease has important mechanistic implications for this class of enzymes.	Aspartic Acid	61-64	coagulation factor II, thrombin	Homo sapiens	77-92
2657740-0	1989	Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells.	Aspartic Acid	46-59	insulin II	Mus musculus	30-40
2525104-0	1989	A substrate of the cell-attachment sequence of fibronectin (Arg-Gly-Asp-Ser) is sufficient to promote transition of arterial smooth muscle cells from a contractile to a synthetic phenotype.	Aspartic Acid	68-71	fibronectin 1	Rattus norvegicus	47-58
2525104-3	1989	Here, the ability of the cell-attachment sequence of fibronectin, Arg-Gly-Asp-Ser (RGDS), to promote this process was studied.	Aspartic Acid	74-77	fibronectin 1	Rattus norvegicus	53-64
2525104-3	1989	Here, the ability of the cell-attachment sequence of fibronectin, Arg-Gly-Asp-Ser (RGDS), to promote this process was studied.	Aspartic Acid	74-77	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	83-87
2811897-3	1989	The catalytic His and Asp residues tentatively identified in p14 together with the Ser residue of the GDSGG sequence, presumably, constitute the "catalytic triad" characteristic of chymotrypsin-like proteases.	Aspartic Acid	22-25	ribonuclease P/MRP subunit p14	Homo sapiens	61-64
2499329-2	1989	Glucose-6-phosphate dehydrogenase from the yeast Pichia jadinii has a reactive lysine residue in a segment of amino acid sequence Ile-Asp-His-Tyr-Leu-Gly-Lys*-Glu-Met-Val-Lys.	Aspartic Acid	134-137	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
2504277-5	1989	The tryptase sequence includes the essential residues of the catalytic triad and an aspartic acid at the base of the putative substrate binding pocket that confers P1 Arg and Lys specificity on tryptic serine proteases.	Aspartic Acid	84-97	tryptase	Canis lupus familiaris	4-12
2784982-3	1989	This evidence supports a double-displacement covalent mechanism for porcine pancreatic alpha-amylase-catalyzed hydrolysis of glycosidic linkages, based on the presence of catalytic aspartic acid residues within the active site of this enzyme.	Aspartic Acid	181-194	amylase alpha 2A	Homo sapiens	76-100
2542835-8	1989	The enhancement of aspartate signal transduction by glycine and D-serine was inhibited by the noncompetitive GC1 receptor antagonist, phencyclidine, but was even more evident in presence of Mg2+ ions.	Aspartic Acid	19-28	solute carrier family 25 member 22	Rattus norvegicus	109-112
2708912-8	1989	It is shown in addition that the tripeptide Arg-Gly-Asp, identical to the region of iC3b recognized by CR3 and by several adhesion-promoting receptors that are structurally similar to CR3, such as fibronectin or vitronectin, is a significant inhibitor of the binding to and the phagocytosis of S-RBC by monocytic-macrophagic cells.	Aspartic Acid	52-55	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	103-106
2708912-8	1989	It is shown in addition that the tripeptide Arg-Gly-Asp, identical to the region of iC3b recognized by CR3 and by several adhesion-promoting receptors that are structurally similar to CR3, such as fibronectin or vitronectin, is a significant inhibitor of the binding to and the phagocytosis of S-RBC by monocytic-macrophagic cells.	Aspartic Acid	52-55	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	184-187
2708912-8	1989	It is shown in addition that the tripeptide Arg-Gly-Asp, identical to the region of iC3b recognized by CR3 and by several adhesion-promoting receptors that are structurally similar to CR3, such as fibronectin or vitronectin, is a significant inhibitor of the binding to and the phagocytosis of S-RBC by monocytic-macrophagic cells.	Aspartic Acid	52-55	vitronectin	Homo sapiens	212-223
2660900-4	1989	A search for other mutations in N-RAS exon-1 in T-ALL revealed a codon 13 mutation substituting aspartic acid (GAT) for glycine (GGT) in one of 18 patients.	Aspartic Acid	96-109	NRAS proto-oncogene, GTPase	Homo sapiens	32-37
2660900-4	1989	A search for other mutations in N-RAS exon-1 in T-ALL revealed a codon 13 mutation substituting aspartic acid (GAT) for glycine (GGT) in one of 18 patients.	Aspartic Acid	96-109	glycine-N-acyltransferase	Homo sapiens	111-114
2666264-2	1989	PEPC activity encoded by the cloned gene is not affected by acetyl-CoA under conditions where the E. coli enzyme is strongly activated, whereas acetyl-CoA is able to relieve inhibition by L-aspartate used singly or in combination with alpha-ketoglutarate.	Aspartic Acid	188-199	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	0-4
2712830-1	1989	Fibronectin, von Willebrand factor, and fibrinogen each bind to the glycoprotein IIb-IIIa complex on activated platelets via an arg-gly-asp-ser (RGDS) sequence present within the adhesive proteins.	Aspartic Acid	136-139	fibronectin 1	Homo sapiens	0-11
2712830-1	1989	Fibronectin, von Willebrand factor, and fibrinogen each bind to the glycoprotein IIb-IIIa complex on activated platelets via an arg-gly-asp-ser (RGDS) sequence present within the adhesive proteins.	Aspartic Acid	136-139	ral guanine nucleotide dissociation stimulator	Homo sapiens	145-149
2564421-4	1989	Activities of the thiamine-dependent enzyme alpha-ketoglutarate dehydrogenase (alpha KGDH) were decreased in parallel with the aspartate decreases; pyruvate dehydrogenase complex activities were unchanged in all brain regions.	Aspartic Acid	127-136	oxoglutarate dehydrogenase	Rattus norvegicus	44-77
2742826-4	1989	While resonances from residues Ala(1)-Glu(5) were little affected, binding of fibrinopeptide A to thrombin caused significant line broadening of NH and side-chain proton resonances within residues Asp(7)-Arg(16).	Aspartic Acid	197-200	coagulation factor II, thrombin	Homo sapiens	98-106
2742826-5	1989	There is a chain reversal within residues Asp(7)-Arg(16) such that Phe(8) is brought close to the Arg(16)-Gly(17) peptide bond in the thrombin-peptide complex, as indicated by transferred NOEs between the aromatic ring protons of Phe(8) and the C alpha H protons of Gly(14) and the C gamma H protons of Val(15).	Aspartic Acid	42-45	coagulation factor II, thrombin	Homo sapiens	134-142
2742828-5	1989	Medium- and long-range TRNOE"s were observed between the NH proton of Asp(7) and the C beta H protons of Ala(10) and between the ring protons of Phe(8) and the C gamma H protons of Val(12) and Val(15) in complexes of thrombin with both tF16 and tF17.	Aspartic Acid	70-73	coagulation factor II, thrombin	Homo sapiens	217-225
2493989-5	1989	Nucleotide sequence analysis of a Zfy-2 cDNA suggests that it encodes a 783 amino acid protein with two domains: the amino-terminal portion is highly acidic, with 25% of its residues being glutamic or aspartic acid, while the carboxy-terminal domain contains 13 zinc fingers.	Aspartic Acid	201-214	zinc finger protein 2, Y-linked	Mus musculus	34-39
2784439-9	1989	These data suggest that the expression of integrin alpha subunits can be regulated differentially and independently of the beta subunit and that the VLA-1 heterodimer has an important function in mediating Arg-Gly-Asp-dependent cell adhesion or other phenotypic properties in human neuroblastoma cells.	Aspartic Acid	214-217	integrin subunit alpha 1	Homo sapiens	149-154
2500135-3	1989	As with almost all reported gonadotropin alpha-subunits, NH2-terminal heterogeneity was found in the porcine FSH alpha-subunit (FSH alpha), starting with residue Phe (1), Asp (3), Gly (4), or Thr (7).	Aspartic Acid	171-174	glycoprotein hormones, alpha polypeptide	Homo sapiens	109-137
2925797-7	1989	These observations indicate that the main effect of AICA-Riboside is on the formation of AMP from aspartate and IMP via the sequential action of adenylosuccinate synthetase and adenylosuccinate lyase.	Aspartic Acid	98-107	adenylosuccinate lyase	Rattus norvegicus	177-199
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Aspartic Acid	105-108	fibronectin 1	Mus musculus	23-34
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Aspartic Acid	105-108	progastricsin (pepsinogen C)	Mus musculus	134-137
2521835-6	1989	These cells are able to adhere to fibronectin-coated dishes by a mechanism that is inhibitable by a synthetic hexapeptide containing the arg-gly-asp cell recognition sequence of fibronectin.	Aspartic Acid	145-148	fibronectin 1	Rattus norvegicus	34-45
2521835-6	1989	These cells are able to adhere to fibronectin-coated dishes by a mechanism that is inhibitable by a synthetic hexapeptide containing the arg-gly-asp cell recognition sequence of fibronectin.	Aspartic Acid	145-148	fibronectin 1	Rattus norvegicus	178-189
2521674-8	1989	It is of interest that nsP4 contains the Gly-Asp-Asp motif characteristic of a number of viral replicases, and this, together with the fact that all RNA synthesis in ts6-infected cells and, to a lesser extent, in ts110-infected cells shut off when the cells were shifted from a permissive to a nonpermissive temperature, suggests that nsP4 is the virus polymerase.	Aspartic Acid	45-48	serine protease 57	Homo sapiens	23-27
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Aspartic Acid	105-108	fibronectin 1	Mus musculus	150-161
2521674-8	1989	It is of interest that nsP4 contains the Gly-Asp-Asp motif characteristic of a number of viral replicases, and this, together with the fact that all RNA synthesis in ts6-infected cells and, to a lesser extent, in ts110-infected cells shut off when the cells were shifted from a permissive to a nonpermissive temperature, suggests that nsP4 is the virus polymerase.	Aspartic Acid	49-52	serine protease 57	Homo sapiens	23-27
2537118-0	1989	Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity.	Aspartic Acid	83-86	fibrinogen beta chain	Homo sapiens	0-10
2642907-6	1989	In rat liver, aspartyl-tRNA synthetase occurs in two distinct forms: a dimeric enzyme and a component of a multienzyme complex comprising the nine aminoacyl-tRNA synthetases specific for arginine, aspartic acid, glutamic acid, glutamine, isoleucine, leucine, lysine, methionine, and proline.	Aspartic Acid	197-210	aspartyl-tRNA synthetase 1	Rattus norvegicus	14-38
2914942-0	1989	A single base mutation that converts glycine 907 of the alpha 2(I) chain of type I procollagen to aspartate in a lethal variant of osteogenesis imperfecta.	Aspartic Acid	98-107	collagen type I alpha 2 chain	Homo sapiens	76-94
2914942-10	1989	Therefore, the single base substitution that converts glycine 907 in the alpha 2(I) chain to aspartate is solely responsible for the decreased thermal stability of the type I procollagen synthesized by the proband"s fibroblasts.	Aspartic Acid	93-102	collagen type I alpha 2 chain	Homo sapiens	168-186
2465036-5	1989	One epitope has been mapped to the 25-amino acid sequence lys-338 through asp-362 of F.VIII (E338-362).	Aspartic Acid	74-77	coagulation factor VIII	Homo sapiens	85-91
2912899-0	1989	Antibodies raised against synthetic peptides from the Arg-Gly-Asp-containing region of the Leishmania surface protein gp63 cross-react with human C3 and interfere with gp63-mediated binding to macrophages.	Aspartic Acid	62-65	leishmanolysin like peptidase	Homo sapiens	118-122
2912899-0	1989	Antibodies raised against synthetic peptides from the Arg-Gly-Asp-containing region of the Leishmania surface protein gp63 cross-react with human C3 and interfere with gp63-mediated binding to macrophages.	Aspartic Acid	62-65	leishmanolysin like peptidase	Homo sapiens	168-172
2912899-2	1989	Antibody raised against a synthetic peptide containing the Arg-Gly-Asp region of the amino acid sequence of gp63 recognizes both gp63 and the alpha-chain of human C3.	Aspartic Acid	67-70	leishmanolysin like peptidase	Homo sapiens	108-112
2912899-2	1989	Antibody raised against a synthetic peptide containing the Arg-Gly-Asp region of the amino acid sequence of gp63 recognizes both gp63 and the alpha-chain of human C3.	Aspartic Acid	67-70	leishmanolysin like peptidase	Homo sapiens	129-133
2915989-9	1989	We conclude that the Asp-70----Gly mutation (acidic to neutral amino acid substitution) accounts for reduced affinity of atypical cholinesterase for choline esters and that Asp-70 must be an important component of the anionic site.	Aspartic Acid	21-24	butyrylcholinesterase	Homo sapiens	130-144
2915693-3	1989	Although Ca2+ is not directly involved in the catalytic mechanism and is 16.6 A away from the alpha-carbon atoms of the catalytic triad Asp 39-His 69-Ser 224, the activity of proteinase K towards the synthetic substrate succinyl-Ala-Ala-Ala-p-nitroanilide drops slowly to approximately 20% of its original value when it is depleted of Ca2+.	Aspartic Acid	136-139	endogenous retrovirus group K member 7	Homo sapiens	175-185
2598662-1	1989	The major, non-amelogenin protein component (enamelin) present in EDTA or EDTA-GU HCl extracts of developing bovine enamel has a molecular weight of approximately 67 kD and an amino acid composition rich in asp, glu, ala, leuc and lys.	Aspartic Acid	207-210	enamelin	Bos taurus	45-53
2539862-6	1989	In particular, the introduction of the additional carboxylate carried by p-(chloromercuri)benzoate near Asp-127 and Glu-130 increases the initial rate of iron uptake and affects the coordination geometry of the metal in the Fe(III)-apoferritin complex as indicated by optical absorption and EPR data.	Aspartic Acid	104-107	ferritin heavy chain 1	Homo sapiens	232-243
2481394-4	1989	A sequence comparison of this and tissue kallikrein (pancreatic kallikrein) indicates the key a.a. residues for serine protease activity (HIS-ASP-SER) and cleavage specificity at basic a.a. Northern blot analysis using a specific oligonucleotide probe reveals that this gene is expressed specifically in the kidney but not in the pancreas.	Aspartic Acid	142-145	kallikrein 1-related peptidase B3	Rattus norvegicus	53-74
2485094-2	1989	We discovered an 8 amino acid region (Leu-Ser-Glu-Asp-Leu-Leu-Ser- Ile in human TPO) in which there were 6 identical and 2 conserved amino acid residues when compared with human Tg.	Aspartic Acid	50-53	thyroid peroxidase	Homo sapiens	80-83
2698313-4	1989	The cDNA sequence indicated the presence of a Gly-Arg-Gly-Asp-Ser- (GRGDS) amino acid sequence identical to a cell binding sequence in fibronectin, and suggested that osteopontin might function as a cell attachment factor.	Aspartic Acid	58-61	secreted phosphoprotein 1	Homo sapiens	167-178
2806936-4	1989	To modify this interaction, we placed a peptide containing the arginine-glycine-aspartic acid sequence that competes for the cellular binding site of fibronectin onto the collagen gels.	Aspartic Acid	80-93	fibronectin 1	Homo sapiens	150-161
2462607-0	1989	CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide.	Aspartic Acid	56-59	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	0-3
2659426-4	1989	Most recently, it has been claimed that an aspartic acid in position 57 of the DQB1 (DQ-beta-1) chain confers resistance to IDDM.	Aspartic Acid	43-56	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	79-83
2659426-4	1989	Most recently, it has been claimed that an aspartic acid in position 57 of the DQB1 (DQ-beta-1) chain confers resistance to IDDM.	Aspartic Acid	43-56	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	85-94
2462607-0	1989	CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide.	Aspartic Acid	56-59	integrin subunit alpha M	Homo sapiens	5-10
2462607-0	1989	CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide.	Aspartic Acid	56-59	integrin subunit beta 2	Homo sapiens	11-15
2974038-2	1988	Two sites, the Arg-Gly-Asp-Ser-containing cell attachment domain and a site located in the first 70 kDa of fibronectin, are required for matrix assembly.	Aspartic Acid	23-26	fibronectin 1	Homo sapiens	107-118
2470110-1	1989	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Aspartic Acid	114-117	GRDX	Homo sapiens	32-35
2470110-1	1989	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Aspartic Acid	114-117	fibronectin 1	Homo sapiens	148-159
2470110-1	1989	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Aspartic Acid	114-117	vitronectin	Homo sapiens	164-175
2470110-2	1989	This report demonstrates that human melanoma cells (M21) synthesize and express a glycoprotein receptor that shares antigenic epitopes with the vitronectin receptor on human fibroblasts and is capable of specifically recognizing the Gly-Arg-Gly-Asp-Ser-Pro sequence.	Aspartic Acid	245-248	vitronectin	Homo sapiens	144-155
2461939-2	1988	The amino acid sequence of BSP contains an Arg-Gly-Asp (RGD) sequence which confers to the protein cell binding properties (Oldberg, A., Franzen, A., and Heinegard, D. (1988) J. Biol.	Aspartic Acid	51-54	integrin-binding sialoprotein	Rattus norvegicus	27-30
3238653-5	1988	These studies suggest that the glycoprotein IIb-IIIa complex on activated platelets may interact with vitronectin substrate through the Arg-Gly-Asp mechanism.	Aspartic Acid	144-147	vitronectin	Homo sapiens	102-113
2564172-1	1989	The relationship between long-term potentiation of synaptic transmission and the release of endogenous glutamate and aspartate has been investigated in the CA1 region of the hippocampus and in the fascia dentata of the anaesthetized rat.	Aspartic Acid	117-126	carbonic anhydrase 1	Rattus norvegicus	156-159
2563916-4	1989	Kainic acid (AA3), quisqualic acid (AA2), and AMPA (AA2) resulted in dose-dependent reductions in all four neurochemical markers examined, while N-methyl-D,L-aspartate (AA1) and quinolinic acid (AA1) resulted in relative sparing of SLI and NPYLI.	Aspartic Acid	156-167	AA2	Homo sapiens	36-39
2563916-4	1989	Kainic acid (AA3), quisqualic acid (AA2), and AMPA (AA2) resulted in dose-dependent reductions in all four neurochemical markers examined, while N-methyl-D,L-aspartate (AA1) and quinolinic acid (AA1) resulted in relative sparing of SLI and NPYLI.	Aspartic Acid	156-167	AA2	Homo sapiens	52-55
2563916-4	1989	Kainic acid (AA3), quisqualic acid (AA2), and AMPA (AA2) resulted in dose-dependent reductions in all four neurochemical markers examined, while N-methyl-D,L-aspartate (AA1) and quinolinic acid (AA1) resulted in relative sparing of SLI and NPYLI.	Aspartic Acid	156-167	AA1	Homo sapiens	169-172
3198635-6	1988	BSP contains an Arg-Gly-Asp sequence, which presumably is responsible for its cell binding properties (Oldberg, A., Franzen, A., Heinegard, D., Pierschbacher, M., and Ruoslahti, E. (1988) J. Biol.	Aspartic Acid	24-27	integrin-binding sialoprotein	Rattus norvegicus	0-3
3057885-7	1988	The presence or absence of Asp at position 57 of the DQ beta gene, recently implicated in IDDM predisposition, is not by itself sufficient to explain the inheritance of IDDM.	Aspartic Acid	27-30	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	53-60
3197838-6	1988	The sequence of bovine angiogenin contains the cell recognition tripeptide Arg-Gly-Asp which is not present in the human protein.	Aspartic Acid	83-86	angiogenin	Homo sapiens	23-33
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Aspartic Acid	163-166	fibronectin 1	Mus musculus	203-214
2848742-8	1988	Attachment to and syncytia formation on fibronectin was blocked by the addition of the R-G-D-S-containing peptide, Gly-Arg-Gly-Asp-Ser-Pro.	Aspartic Acid	127-130	fibronectin 1	Homo sapiens	40-51
3182196-0	1988	Aspartate separation of the scotopic threshold response (STR) from the photoreceptor a-wave of the cat and monkey ERG.	Aspartic Acid	0-9	ETS transcription factor ERG	Homo sapiens	114-117
3264556-9	1988	The Arg-Gly-Asp cell recognition sequence is present in one of the EGF-type repeats, and a synthetic peptide from the putative cell-binding site of entactin was found to promote the attachment of mouse mammary tumor cells.	Aspartic Acid	12-15	nidogen 1	Mus musculus	148-156
3252892-4	1988	The most strongly associated interaction is the chelation of iron by transferrin, with an association constant of approximately 10(21); tyrosines, histidines, and sometimes aspartate are involved.	Aspartic Acid	173-182	transferrin	Homo sapiens	69-80
3145192-7	1988	This phenotype was caused by a single chromosomal mutation, leading to the replacement of aspartic acid 40 of the RAS2 protein by asparagine.	Aspartic Acid	90-103	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	114-118
2902197-0	1988	Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen.	Aspartic Acid	28-37	carbonic anhydrase 1	Rattus norvegicus	77-80
3053736-7	1988	Although different in activation pathways and recognition specificity, Mac-1 exhibits an oligospecific ligand versatility characteristic of other homologous Arg-Gly-Asp-directed adhesion receptors.	Aspartic Acid	165-168	integrin subunit alpha M	Homo sapiens	71-76
2902197-1	1988	Glutamate and/or aspartate is the probable transmitter released from synaptic terminals of the CA3-derived Schaffer collateral, commissural, and ipsilateral associational fibers in area CA1 of the rat hippocampal formation.	Aspartic Acid	17-26	carbonic anhydrase 3	Rattus norvegicus	95-98
2902197-1	1988	Glutamate and/or aspartate is the probable transmitter released from synaptic terminals of the CA3-derived Schaffer collateral, commissural, and ipsilateral associational fibers in area CA1 of the rat hippocampal formation.	Aspartic Acid	17-26	carbonic anhydrase 1	Rattus norvegicus	186-189
2902197-2	1988	Slices of the CA1 area were employed to test the effects of adenosine- and gamma-aminobutyrate (GABA)-related compounds on the release of glutamate and aspartate from this projection.	Aspartic Acid	152-161	carbonic anhydrase 1	Rattus norvegicus	14-17
2902197-3	1988	Under the conditions of these experiments, the release of glutamate and aspartate evoked by 50 mM K+ was more than 90% Ca2+-dependent and originated predominantly from the CA3-derived pathways.	Aspartic Acid	72-81	carbonic anhydrase 2	Rattus norvegicus	119-122
2902197-3	1988	Under the conditions of these experiments, the release of glutamate and aspartate evoked by 50 mM K+ was more than 90% Ca2+-dependent and originated predominantly from the CA3-derived pathways.	Aspartic Acid	72-81	carbonic anhydrase 3	Rattus norvegicus	172-175
2458338-1	1988	The cell surface receptor for fibronectin is a heterodimeric membrane protein that recognizes an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for binding to fibronectin.	Aspartic Acid	105-108	fibronectin 1	Homo sapiens	30-41
2485226-9	1988	Moreover, they provide evidence that the Arg-Gly-Asp sequence is the only, or essential, GP IIb-IIIa binding site in the vWF molecule.	Aspartic Acid	49-52	integrin alpha-IIb	Oryctolagus cuniculus	89-95
2485226-9	1988	Moreover, they provide evidence that the Arg-Gly-Asp sequence is the only, or essential, GP IIb-IIIa binding site in the vWF molecule.	Aspartic Acid	49-52	LOW QUALITY PROTEIN: von Willebrand factor	Oryctolagus cuniculus	121-124
2460346-0	1988	Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets.	Aspartic Acid	14-17	fibronectin 1	Homo sapiens	57-68
2460346-0	1988	Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets.	Aspartic Acid	14-17	fibrinogen beta chain	Homo sapiens	70-80
2460346-1	1988	An antibody population recognizing the sequence Arg-Gly-Asp-Ser (RGDS) in fibronectin, anti-(RGDS)N, was isolated by immunoadsorption.	Aspartic Acid	56-59	ral guanine nucleotide dissociation stimulator	Homo sapiens	65-69
2460346-1	1988	An antibody population recognizing the sequence Arg-Gly-Asp-Ser (RGDS) in fibronectin, anti-(RGDS)N, was isolated by immunoadsorption.	Aspartic Acid	56-59	fibronectin 1	Homo sapiens	74-85
2460346-1	1988	An antibody population recognizing the sequence Arg-Gly-Asp-Ser (RGDS) in fibronectin, anti-(RGDS)N, was isolated by immunoadsorption.	Aspartic Acid	56-59	ral guanine nucleotide dissociation stimulator	Homo sapiens	93-97
3171483-4	1988	The 9.9-kD pro-portion of proMBP is rich in glutamic and aspartic acids and has a calculated pI of 3.9, while proMBP itself has a calculated pI of 6.2.	Aspartic Acid	57-71	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	26-32
3150544-2	1988	One of these new derivatives, FVIII delta II, in which amino acids 771(pro)-1666(asp) have been deleted, no longer contains the protease cleavage site at amino acid position 1648(arg)-1649(glu) known to be involved in the initial step of FVIII processing.	Aspartic Acid	81-84	coagulation factor VIII	Homo sapiens	30-35
2849988-8	1988	Sequence comparisons of RSKG-7, RSKG-3, and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity (His/Asp/Ser) and kallikrein-like cleavage specificity at basic amino acids.	Aspartic Acid	158-161	kallikrein 1	Rattus norvegicus	24-30
2971573-4	1988	The sequence, Ala-Pro-Arg-Ser-Ser-Asp-Cys-Phe-Gly-Ser-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln- Ser-Gly - Met-Gly-Cys-Gly-Arg-(Phe), is highly homologous to known mammalian ANF sequences.	Aspartic Acid	34-37	natriuretic peptide A	Homo sapiens	164-167
3196309-9	1988	Also, by using a more highly purified preparation, it has been found that position 50 in PRP-2 and PRP-4 is Asp, rather than Asn previously reported.	Aspartic Acid	108-111	transmembrane protein 171	Homo sapiens	89-94
3196309-9	1988	Also, by using a more highly purified preparation, it has been found that position 50 in PRP-2 and PRP-4 is Asp, rather than Asn previously reported.	Aspartic Acid	108-111	pre-mRNA processing factor 4B	Homo sapiens	99-104
2459697-0	1988	Mutagenesis of aspartic acid-116 enhances the ribonucleolytic activity and angiogenic potency of angiogenin.	Aspartic Acid	15-28	ribonuclease A family member k6	Gallus gallus	97-107
2459697-2	1988	Replacement of Asp-116 in angiogenin by either asparagine (D116N), alanine (D116A), or histidine (D116H) markedly enhances both its ribonucleolytic activity and angiogenic potency.	Aspartic Acid	15-18	ribonuclease A family member k6	Gallus gallus	26-36
2849988-8	1988	Sequence comparisons of RSKG-7, RSKG-3, and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity (His/Asp/Ser) and kallikrein-like cleavage specificity at basic amino acids.	Aspartic Acid	158-161	kallikrein 1-related peptidase C12	Rattus norvegicus	32-38
2849988-8	1988	Sequence comparisons of RSKG-7, RSKG-3, and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity (His/Asp/Ser) and kallikrein-like cleavage specificity at basic amino acids.	Aspartic Acid	158-161	kallikrein 1-related peptidase C8	Rattus norvegicus	128-143
2458338-1	1988	The cell surface receptor for fibronectin is a heterodimeric membrane protein that recognizes an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for binding to fibronectin.	Aspartic Acid	105-108	fibronectin 1	Homo sapiens	121-132
2458338-1	1988	The cell surface receptor for fibronectin is a heterodimeric membrane protein that recognizes an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for binding to fibronectin.	Aspartic Acid	105-108	fibronectin 1	Homo sapiens	121-132
2458338-8	1988	The increased fibronectin receptor activity in the presence of Mn2+ appeared to be due to an increase in the affinity of the receptor for the Arg-Gly-Asp sequence because a 110-kDa cell attachment fragment and a synthetic hexapeptide containing the Arg-Gly-Asp sequence inhibited liposome binding more effectively in the presence of Mn2+ than in the presence of Ca2+/Mg2+.	Aspartic Acid	150-153	fibronectin 1	Homo sapiens	14-25
2458338-8	1988	The increased fibronectin receptor activity in the presence of Mn2+ appeared to be due to an increase in the affinity of the receptor for the Arg-Gly-Asp sequence because a 110-kDa cell attachment fragment and a synthetic hexapeptide containing the Arg-Gly-Asp sequence inhibited liposome binding more effectively in the presence of Mn2+ than in the presence of Ca2+/Mg2+.	Aspartic Acid	257-260	fibronectin 1	Homo sapiens	14-25
3065149-6	1988	Variants of PSTI with Asp or Asn at aa positions 21 and 29 [sequences published by Greene et al., Methods Enzymol.	Aspartic Acid	22-25	serine peptidase inhibitor Kazal type 1	Homo sapiens	12-16
3417645-2	1988	The platelet membrane glycoprotein IIb-IIIa complex (GPIIb-IIIa) recognizes peptides containing the amino acid sequence Arg-Gly-Asp, a sequence present at two locations in the alpha chain of fibrinogen.	Aspartic Acid	128-131	fibrinogen beta chain	Homo sapiens	191-201
3045563-5	1988	TRAP also shares with certain extracellular glycoproteins, including TSP, the cell-recognition signal Arg-Gly-Asp (RGD), which has been shown to be crucial in the interaction of several extracellular glycoproteins with members of the integrin superfamily.	Aspartic Acid	110-113	TRAP	Homo sapiens	0-4
3410852-4	1988	Less conventional chemical reactions, including cyanogen bromide-induced cleavage at tryptophan and acid-induced cleavage at aspartic acid, were used successfully to obtain peptides which allowed definition of the amino acid sequence of MBP.	Aspartic Acid	125-138	myelin basic protein	Homo sapiens	237-240
3066243-6	1988	A synthetic peptide Gly-Arg-Gly-Asp-Ser, representing the host cell attachment site of fibronectin, partially inhibited the binding of fibronectin and of its 210 kD fragment to S dysgalactiae, but not to S equi.	Aspartic Acid	32-35	fibronectin 1	Bos taurus	87-98
3066243-6	1988	A synthetic peptide Gly-Arg-Gly-Asp-Ser, representing the host cell attachment site of fibronectin, partially inhibited the binding of fibronectin and of its 210 kD fragment to S dysgalactiae, but not to S equi.	Aspartic Acid	32-35	fibronectin 1	Bos taurus	135-146
3243667-1	1988	The solubility prediction method for protected peptides was successfully applied to relatively small peptide fragments of human hemoglobin alpha-chain (123-136) which contained various polar amino acid residues such as Asp(OBzl), Glu(OBzl), Lys(Z), Ser(Bzl), and Thr(Bzl).	Aspartic Acid	219-222	hemoglobin subunit alpha 2	Homo sapiens	128-150
3135226-2	1988	The ratio of the serum aspartate to alanine amino-transferase levels (AST/ALT) is often used as a clue to the etiology of the underlying liver disease.	Aspartic Acid	23-32	solute carrier family 17 member 5	Homo sapiens	70-73
3045563-5	1988	TRAP also shares with certain extracellular glycoproteins, including TSP, the cell-recognition signal Arg-Gly-Asp (RGD), which has been shown to be crucial in the interaction of several extracellular glycoproteins with members of the integrin superfamily.	Aspartic Acid	110-113	thrombospondin 1	Homo sapiens	69-72
3403546-6	1988	The cofilin sequence contains a hexapeptide (Asp-Ala-Ile-Lys-Lys-Lys) identical to the amino-terminal sequence (residues 2-7) of muscle and nonmuscle tropomyosin.	Aspartic Acid	45-48	cofilin 1	Homo sapiens	4-11
3042778-8	1988	Putative Sec7p contains an unusual, highly charged acidic domain of 125 amino acids with 29% glutamate, 18% aspartate, and 21% serine.	Aspartic Acid	108-117	Arf family guanine nucleotide exchange factor SEC7	Saccharomyces cerevisiae S288C	9-14
3191112-3	1988	At least two well-defined sequences in fibrinogen, Arg-Gly-Asp sequence of A alpha 95-97 and A alpha 572-574 and gamma 400-411, have been shown to interact with glycoprotein IIb-IIIa.	Aspartic Acid	59-62	fibrinogen beta chain	Homo sapiens	39-49
3065674-1	1988	The purpose of the present study was to determine whether gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus of the prepubertal monkey may be prematurely provoked into producing a sustained train of intermittent GnRH release N-methyl-DL-aspartic acid (NMA), an analog of the putative excitatory neurotransmitter aspartate, was used to stimulate the hypothalamus.	Aspartic Acid	327-336	gonadotropin releasing hormone 1	Macaca mulatta	227-231
2840819-2	1988	The mutation of the A(+) gene is a single nucleotide transition, A/G in equilibrium Asp) in the G6PD protein and produces an additional FokI cleavage site of the mutation site.	Aspartic Acid	84-87	glucose-6-phosphate dehydrogenase	Homo sapiens	96-100
3065674-1	1988	The purpose of the present study was to determine whether gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus of the prepubertal monkey may be prematurely provoked into producing a sustained train of intermittent GnRH release N-methyl-DL-aspartic acid (NMA), an analog of the putative excitatory neurotransmitter aspartate, was used to stimulate the hypothalamus.	Aspartic Acid	327-336	gonadotropin releasing hormone 1	Macaca mulatta	58-88
3065674-1	1988	The purpose of the present study was to determine whether gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus of the prepubertal monkey may be prematurely provoked into producing a sustained train of intermittent GnRH release N-methyl-DL-aspartic acid (NMA), an analog of the putative excitatory neurotransmitter aspartate, was used to stimulate the hypothalamus.	Aspartic Acid	327-336	gonadotropin releasing hormone 1	Macaca mulatta	90-94
3288632-0	1988	Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.	Aspartic Acid	8-17	Dihydrofolate reductase	Escherichia coli	55-78
3187957-6	1988	Shear-induced platelet aggregation was inhibited by monoclonal antibody to GPIIb/IIIa (1 microgram/ml) and synthetic peptide, Arg-Gly-Asp-Ser (RGDS) (1 mM).	Aspartic Acid	134-137	ral guanine nucleotide dissociation stimulator	Homo sapiens	143-147
3045810-7	1988	In the C-terminal third of the MAK16 open reading frame is an acidic region in which 25 of 41 residues are either glutamate or aspartate.	Aspartic Acid	127-136	ribosome biosynthesis protein MAK16	Saccharomyces cerevisiae S288C	31-36
3294332-0	1988	Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes.	Aspartic Acid	53-56	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	0-31
2968824-2	1988	The cell attachment site of fibronectin with its crucial arg-gly-asp(-ser) [RGD(S)]sequence is involved in these bindings.	Aspartic Acid	65-68	fibronectin 1	Homo sapiens	28-39
2455726-8	1988	This "catch-up" was counteracted by a peptide that contained the cell-attachment sequence of fibronectin (Arg-Gly-Asp-Ser).	Aspartic Acid	114-117	fibronectin 1	Rattus norvegicus	93-104
2899418-0	1988	Ca2+-dependent activation of the malate-aspartate shuttle by norepinephrine and vasopressin in perfused rat liver.	Aspartic Acid	40-49	arginine vasopressin	Rattus norvegicus	80-91
3065335-11	1988	Key amino acid residues, His(41), Asp(96), and Ser(190), required for catalytic activity and Asp (184) required for kallikrein-type specificity are completely conserved.	Aspartic Acid	34-37	kallikrein related peptidase 4	Homo sapiens	116-126
3065335-11	1988	Key amino acid residues, His(41), Asp(96), and Ser(190), required for catalytic activity and Asp (184) required for kallikrein-type specificity are completely conserved.	Aspartic Acid	93-96	kallikrein related peptidase 4	Homo sapiens	116-126
3294332-0	1988	Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes.	Aspartic Acid	53-56	leishmanolysin like peptidase	Homo sapiens	110-114
3290901-4	1988	Substitution of aspartic acid residue 25 (Asp-25) of this protein with an asparagine residue did not affect the expression of the protein, but it eliminated detectable in vitro proteolytic activity against HIV gag p55.	Aspartic Acid	16-29	H3 histone pseudogene 44	Homo sapiens	214-217
3072564-5	1988	However, acid solutions of insulin are chemically unstable as A21 asparagine both deamidates to aspartic acid and takes part in formation of covalent dimers via alpha-amino groups of other molecules.	Aspartic Acid	96-109	insulin	Sus scrofa	27-34
3290901-4	1988	Substitution of aspartic acid residue 25 (Asp-25) of this protein with an asparagine residue did not affect the expression of the protein, but it eliminated detectable in vitro proteolytic activity against HIV gag p55.	Aspartic Acid	42-45	H3 histone pseudogene 44	Homo sapiens	214-217
3260077-6	1988	Recombinant IL 1 (mol wt 17,500) reproduced changes in AMG and aspartate uptake seen with macrophage supernatants.	Aspartic Acid	63-72	interleukin 1 complex	Mus musculus	12-16
2453507-2	1988	We have generated antibodies against a synthetic peptide corresponding to the sequence of human von Willebrand factor (vWF) between residues Glu1737-Ser1750 which includes the Arg-Gly-Asp sequence common to several adhesive molecules.	Aspartic Acid	184-187	von Willebrand factor	Homo sapiens	96-117
2453507-2	1988	We have generated antibodies against a synthetic peptide corresponding to the sequence of human von Willebrand factor (vWF) between residues Glu1737-Ser1750 which includes the Arg-Gly-Asp sequence common to several adhesive molecules.	Aspartic Acid	184-187	von Willebrand factor	Homo sapiens	119-122
3286012-2	1988	Site-specific deletion of the putative recognition sequence Arg-Gly-Asp-Ser or an Asp-to-Glu mutation decreased the adhesive activity of fibronectin fusion proteins expressed in E. coli by greater than or equal to 97%.	Aspartic Acid	68-71	fibronectin 1	Homo sapiens	137-148
3049072-12	1988	This strongly suggests that the aspartic acid residue at this position is essential for catalytic function of lysosomal alpha-glucosidase.	Aspartic Acid	32-45	alpha glucosidase	Homo sapiens	110-137
3169039-6	1988	The formation of both neurite classes on either pFN or CTB was completely inhibited by low concentrations of an RGDS (Arg-Gly-Asp-Ser) peptide in the medium of cultures, indicating the significance of pFN"s binding to cell surface integrin or ganglioside GM1"s possible interaction with integrin for mediating the differentiative process.	Aspartic Acid	126-129	ral guanine nucleotide dissociation stimulator	Homo sapiens	112-116
3286012-2	1988	Site-specific deletion of the putative recognition sequence Arg-Gly-Asp-Ser or an Asp-to-Glu mutation decreased the adhesive activity of fibronectin fusion proteins expressed in E. coli by greater than or equal to 97%.	Aspartic Acid	82-85	fibronectin 1	Homo sapiens	137-148
3202961-1	1988	Guanidinobenzoatase is a cell surface protease associated with cells capable of migration, this enzyme is trypsin-like and cleaves the link peptide Gly-Arg-Gly-Asp of fibronectin.	Aspartic Acid	160-163	fibronectin 1	Homo sapiens	167-178
2966812-5	1988	The cytoadhesive tetrapeptide portion of fibronectin, Arg-Gly-Asp-Ser (250-1,000 micrograms/ml), released 1.94 +/- 0.10 micrograms/ml of elastase from 10(7) neutrophils, in contrast to the lack of release by the control hexapeptide, Arg-Gly-Tyr-Ser-Leu-Gly.	Aspartic Acid	62-65	fibronectin 1	Homo sapiens	41-52
2966812-5	1988	The cytoadhesive tetrapeptide portion of fibronectin, Arg-Gly-Asp-Ser (250-1,000 micrograms/ml), released 1.94 +/- 0.10 micrograms/ml of elastase from 10(7) neutrophils, in contrast to the lack of release by the control hexapeptide, Arg-Gly-Tyr-Ser-Leu-Gly.	Aspartic Acid	62-65	elastase, neutrophil expressed	Homo sapiens	137-145
2898958-6	1988	2-Amino-5-phosphonovaleric acid (APV), 2-amino-7-phosphonoheptanoic acid (APH) and MK-801 all reduced the potassium-evoked efflux of aspartate and glutamate by between 14.9% and 34.3% (P less than 0.05).	Aspartic Acid	133-142	acylaminoacyl-peptide hydrolase	Rattus norvegicus	74-77
2901740-8	1988	Although CCK in the lower 6.0 ng/microliter concentration failed to alter significantly the profile of amino acids in the frontal cortex, the higher 18.0 ng/microliter solution of CCK enhanced the efflux of Glu as well as Asp, but only in the aged rats.	Aspartic Acid	222-225	cholecystokinin	Rattus norvegicus	180-183
3401458-5	1988	Given that it is proposed that the enzyme operates via an E1cb-type mechanism where C-N bond cleavage is rate limiting, it is likely that binding of the C-3 substituent of aspartic acid substrates affects the alignment of the nascent carbanion with the C-N bond for elimination.	Aspartic Acid	172-185	complement C3	Homo sapiens	153-156
2894410-2	1988	Irreversible inhibition of GABA transaminase by microinjection of gamma-vinyl GABA (GVG) led to a decrease in aspartate, glutamate, and glutamine levels and an increase in the GABA level, such that the nitrogen pool remained constant.	Aspartic Acid	110-119	4-aminobutyrate aminotransferase	Rattus norvegicus	27-44
2966181-3	1988	Adhesion to fibronectin does not require platelet activation and is inhibited by soluble fibronectin, antibodies specific for fibronectin, peptides containing the sequence Arg-Gly-Asp and polyclonal antibodies specific for band 3 of the chicken embryo fibroblast fibronectin receptor (anti-band 3).	Aspartic Acid	180-183	fibronectin 1	Gallus gallus	12-23
3286820-11	1988	A short peptide derived from fibronectin"s cell-binding domain (Arg-Gly-Asp-Ser) also greatly reduced neurite outgrowth.	Aspartic Acid	72-75	fibronectin 1	Homo sapiens	29-40
2451243-9	1988	One fibronectin-like repeat contains a single Arg-Gly-Asp sequence.	Aspartic Acid	54-57	fibronectin 1	Homo sapiens	4-15
3285178-0	1988	Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities.	Aspartic Acid	46-59	tumor necrosis factor	Homo sapiens	0-32
3280344-0	1988	Functional characterization of Asp-317 mutant of human renin expressed in COS cells.	Aspartic Acid	31-34	renin	Homo sapiens	55-60
3343338-1	1988	The experimental metastasis of B16-F10 murine melanoma cells is blocked by the anti-cell adhesive pentapeptide Gly-Arg-Gly-Asp-Ser (GRGDS) derived from the central cell-binding domain of fibronectin.	Aspartic Acid	123-126	fibronectin 1	Mus musculus	187-198
2447246-0	1988	Racemization of individual aspartate residues in human myelin basic protein.	Aspartic Acid	27-36	myelin basic protein	Homo sapiens	55-75
2449435-2	1988	Liposomes containing platelet glycoproteins IIb-IIIa complex have been shown to bind vitronectin-coated surfaces through an Arg-Gly-Asp cell attachment mechanism.	Aspartic Acid	132-135	vitronectin	Homo sapiens	85-96
2449435-7	1988	A synthetic hexapeptide containing the Arg-Gly-Asp sequence inhibited vitronectin binding to platelets.	Aspartic Acid	47-50	vitronectin	Homo sapiens	70-81
2450468-2	1988	CCK analogues were prepared in which the peptide bond between aspartic acid and phenylalanine had or had not been modified and were lacking the C-terminal primary amide function.	Aspartic Acid	62-75	cholecystokinin	Rattus norvegicus	0-3
2447246-1	1988	Human myelin basic protein (MBP), a long-lived brain protein, undergoes gradual racemization of its amino acids, primarily aspartic acid and serine.	Aspartic Acid	123-136	myelin basic protein	Homo sapiens	6-26
2447246-1	1988	Human myelin basic protein (MBP), a long-lived brain protein, undergoes gradual racemization of its amino acids, primarily aspartic acid and serine.	Aspartic Acid	123-136	myelin basic protein	Homo sapiens	28-31
2447246-5	1988	When the racemization was examined in terms of the beta-structure model of MBP, a correlation was observed in which six aspartate/asparagine residues assumed to be associated with myelin membrane lipids showed little racemization (2.2-4.9% D isomer), whereas five other aspartate residues were more highly racemized (9.9-17.1% D isomer).	Aspartic Acid	120-129	myelin basic protein	Homo sapiens	75-78
2447246-5	1988	When the racemization was examined in terms of the beta-structure model of MBP, a correlation was observed in which six aspartate/asparagine residues assumed to be associated with myelin membrane lipids showed little racemization (2.2-4.9% D isomer), whereas five other aspartate residues were more highly racemized (9.9-17.1% D isomer).	Aspartic Acid	270-279	myelin basic protein	Homo sapiens	75-78
2452461-4	1988	A second peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 isolated from the extracts is identical to human neurokinin A.	Aspartic Acid	29-32	tachykinin precursor 1	Homo sapiens	110-122
3278172-5	1988	A point mutation of the 12th codon (GGT to GAT) resulting in aspartic acid substitution for glycine was observed.	Aspartic Acid	61-74	glycine-N-acyltransferase	Homo sapiens	43-46
3335549-4	1988	The predicted 388-residue amino acid sequence of human pepsinogen C consists of a signal sequence of 16-amino acid residues, an activation peptide of 43 residues, and the mature pepsin of 329 residues containing the two active-site aspartic acids.	Aspartic Acid	232-246	progastricsin	Homo sapiens	55-67
3126813-2	1988	Both hFSH-beta and mEGF contain the tetrapeptide sequence Thr-Arg-Asp-Leu (TRDL).	Aspartic Acid	66-69	follicle stimulating hormone subunit beta	Homo sapiens	5-14
3275655-8	1988	By relating the NH2-terminal amino acid sequences of these peptides to the sequence of the intact egg-specific protein, the protease was shown to cleave first at a Lys-Asn site and secondly at Arg-Asp.	Aspartic Acid	197-200	egg-specific protein	Bombyx mori	98-118
3693352-1	1987	Peptides containing the tripeptide sequence Arg-Gly-Asp can duplicate or inhibit the cell attachment-promoting effects of fibronectin and vitronectin.	Aspartic Acid	52-55	fibronectin 1	Homo sapiens	122-133
3422188-13	1988	These homologies further establish that GPIIb-IIIa from platelets, together with the vitronectin and the fibronectin receptors, are members of a supergene family of adhesion receptors with a recognition specificity for Arg-Gly-Asp amino acid sequences.	Aspartic Acid	227-230	integrin subunit alpha 2b	Homo sapiens	40-45
3422188-13	1988	These homologies further establish that GPIIb-IIIa from platelets, together with the vitronectin and the fibronectin receptors, are members of a supergene family of adhesion receptors with a recognition specificity for Arg-Gly-Asp amino acid sequences.	Aspartic Acid	227-230	vitronectin	Homo sapiens	85-96
3066670-9	1988	Substituting an alanine, asparagine, aspartic acid, or serine at residue 125 resulted in highly active molecules with CTLL activities similar to that of the natural recombinant IL-2.	Aspartic Acid	37-50	interleukin 2	Homo sapiens	177-181
2466737-6	1988	The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor.	Aspartic Acid	85-88	vitronectin	Homo sapiens	4-15
2466737-6	1988	The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor.	Aspartic Acid	85-88	vitronectin	Homo sapiens	129-140
2466737-6	1988	The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor.	Aspartic Acid	85-88	fibrinogen beta chain	Homo sapiens	142-152
2963329-6	1988	FN bound appreciably to this column and was eluted much more efficiently by a solution of Arg-Gly-Asp-Ser-containing peptide than by a solution of related but inactive Arg-Gly-Glu-Ser-containing peptide.	Aspartic Acid	98-101	fibronectin 1	Homo sapiens	0-2
3693353-10	1987	Amino acid sequencing of the purified tryptic phosphopeptide revealed that this threonine residue lies within the sequence: Ala-Gly-Glu-Thr-Arg-Phe-Thr-Asp-Thr-Arg (residues 51-60 of EF-2).	Aspartic Acid	152-155	eukaryotic translation elongation factor 2	Homo sapiens	183-187
2826445-6	1988	The glutamate-binding characteristics of these isolated protein fractions were very similar to those previously described for the 14-kDa GBP, including estimated dissociation constants for L-glutamate binding of 0.25 and 1 microM, inhibition of glutamate binding by azide and cyanide, and a selectivity of the ligand binding site for L-glutamate and L-aspartate.	Aspartic Acid	350-361	transmembrane protein 132A	Rattus norvegicus	137-140
2446681-1	1988	An arginine-glycine-aspartic acid sequence (RGD in the single letter code for amino acids) is present in the cell attachment site of both vitronectin and fibronectin.	Aspartic Acid	20-33	vitronectin	Ovis aries	138-149
3068006-2	1988	Cells capable of attachment and growth in 5 mM concentrations of a peptide having the sequence Gly-Arg-Gly-Asp-Ser-Pro overproduce the cell surface receptor for fibronectin.	Aspartic Acid	107-110	fibronectin 1	Homo sapiens	161-172
2454175-9	1988	The Asp in C4-A and His in C4-B seem likely to be the major specificity-defining residues.	Aspartic Acid	4-7	complement component 4B (Chido blood group)	Mus musculus	27-31
2856638-2	1988	Two peptides, the completely active carboxyl terminal heptapeptide from CCK (CCK-7), whose sequence is Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2, and the carboxyl terminal heptapeptide from cerulein (CER-7) which has the same sequence as for CCK-7 except for replacement of Met 2 with a Thr 2, both stimulate peripheral receptors in gall bladder, pancreas, and pylorus in the gastrointestinal system.	Aspartic Acid	123-126	protein tyrosine kinase 7 (inactive)	Homo sapiens	72-75
2856638-2	1988	Two peptides, the completely active carboxyl terminal heptapeptide from CCK (CCK-7), whose sequence is Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2, and the carboxyl terminal heptapeptide from cerulein (CER-7) which has the same sequence as for CCK-7 except for replacement of Met 2 with a Thr 2, both stimulate peripheral receptors in gall bladder, pancreas, and pylorus in the gastrointestinal system.	Aspartic Acid	123-126	protein tyrosine kinase 7 (inactive)	Homo sapiens	77-80
2856638-2	1988	Two peptides, the completely active carboxyl terminal heptapeptide from CCK (CCK-7), whose sequence is Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2, and the carboxyl terminal heptapeptide from cerulein (CER-7) which has the same sequence as for CCK-7 except for replacement of Met 2 with a Thr 2, both stimulate peripheral receptors in gall bladder, pancreas, and pylorus in the gastrointestinal system.	Aspartic Acid	123-126	protein tyrosine kinase 7 (inactive)	Homo sapiens	77-80
2856638-3	1988	In contrast, two other very similar peptides, the last four residues of CCK (CCK-4) whose sequence is Trp-Met-Asp-Phe-NH2, and the carboxyl terminal hexapeptide of little gastrin (LGA-6, Tyr-Gly-Trp-Met-Asp-Phe-NH2, i.e., residue 2 deleted relative to CCK-7 and CER-7 sequences), interact specifically with gastrin receptors and not at all or very weakly with peripheral receptors.	Aspartic Acid	110-113	protein tyrosine kinase 7 (inactive)	Homo sapiens	72-75
2856638-3	1988	In contrast, two other very similar peptides, the last four residues of CCK (CCK-4) whose sequence is Trp-Met-Asp-Phe-NH2, and the carboxyl terminal hexapeptide of little gastrin (LGA-6, Tyr-Gly-Trp-Met-Asp-Phe-NH2, i.e., residue 2 deleted relative to CCK-7 and CER-7 sequences), interact specifically with gastrin receptors and not at all or very weakly with peripheral receptors.	Aspartic Acid	110-113	protein tyrosine kinase 7 (inactive)	Homo sapiens	77-82
3693352-1	1987	Peptides containing the tripeptide sequence Arg-Gly-Asp can duplicate or inhibit the cell attachment-promoting effects of fibronectin and vitronectin.	Aspartic Acid	52-55	vitronectin	Homo sapiens	138-149
3500868-9	1987	Substrates composed of synthetic peptides containing the Arg-Gly-Asp-Ser sequence supported thrombin-dependent adhesion but did not support ristocetin-dependent adhesion.	Aspartic Acid	65-68	coagulation factor II, thrombin	Homo sapiens	92-100
3435452-3	1987	Secreted mucin (SM) differed from intracellular mucin (IM) by having a higher proportion of "minor" mucin amino acids (aspartic acid, glutamic acid, glycine and alanine) and a lower proportion of "major" amino acids (serine, proline and threonine).	Aspartic Acid	119-132	solute carrier family 13 member 2	Rattus norvegicus	9-14
3446582-2	1987	The amino acid substitution of Asp in the variant G6PD A(+) for Asn in the normal G6PD B(+) was previously found (A. Yoshida, 1967, Proc.	Aspartic Acid	31-34	glucose-6-phosphate dehydrogenase	Homo sapiens	50-54
2825199-4	1987	As a result, the 128th amino acid, aspartic acid, was replaced with glycine (GAT to GGT).	Aspartic Acid	35-48	gamma-glutamyltransferase light chain 5 pseudogene	Homo sapiens	84-87
2825199-10	1987	The Asp-128 is conserved in aldolase A, B, and C of eukaryotes, including an insect, Drosophila, suggesting that the Asp-128 of the aldolase A protein is likely to be an amino acid residue with a crucial role in maintaining the correct spatial structure or in performing the catalytic function of the enzyme.	Aspartic Acid	4-7	Aldolase 1	Drosophila melanogaster	28-36
2825199-10	1987	The Asp-128 is conserved in aldolase A, B, and C of eukaryotes, including an insect, Drosophila, suggesting that the Asp-128 of the aldolase A protein is likely to be an amino acid residue with a crucial role in maintaining the correct spatial structure or in performing the catalytic function of the enzyme.	Aspartic Acid	4-7	Aldolase 1	Drosophila melanogaster	132-140
2825199-10	1987	The Asp-128 is conserved in aldolase A, B, and C of eukaryotes, including an insect, Drosophila, suggesting that the Asp-128 of the aldolase A protein is likely to be an amino acid residue with a crucial role in maintaining the correct spatial structure or in performing the catalytic function of the enzyme.	Aspartic Acid	117-120	Aldolase 1	Drosophila melanogaster	28-36
2825199-10	1987	The Asp-128 is conserved in aldolase A, B, and C of eukaryotes, including an insect, Drosophila, suggesting that the Asp-128 of the aldolase A protein is likely to be an amino acid residue with a crucial role in maintaining the correct spatial structure or in performing the catalytic function of the enzyme.	Aspartic Acid	117-120	Aldolase 1	Drosophila melanogaster	132-140
3680204-8	1987	According to the nucleotide sequence, the first 2 residues of TnC are threonine-aspartic acid, which is the reverse of the order reported previously.	Aspartic Acid	80-93	tenascin	Oryctolagus cuniculus	62-65
3436696-3	1987	study of pseudo-peptide analogues of the C-terminal tetrapeptide of gastrin, obtained by replacing each peptide bond by a "reduced peptide bond", one at a time, e.g. Boc-Trp psi (CH2NH)Leu-Asp-Phe-NH2 2, Boc-Trp-Leu psi (CH2NH) Asp-Phe-NH2 3, Boc-Trp-Leu-Asp psi (CH2NH)Phe-NH2 4, were reported.	Aspartic Acid	189-192	gastrin	Homo sapiens	68-75
3436696-3	1987	study of pseudo-peptide analogues of the C-terminal tetrapeptide of gastrin, obtained by replacing each peptide bond by a "reduced peptide bond", one at a time, e.g. Boc-Trp psi (CH2NH)Leu-Asp-Phe-NH2 2, Boc-Trp-Leu psi (CH2NH) Asp-Phe-NH2 3, Boc-Trp-Leu-Asp psi (CH2NH)Phe-NH2 4, were reported.	Aspartic Acid	228-231	gastrin	Homo sapiens	68-75
3436696-3	1987	study of pseudo-peptide analogues of the C-terminal tetrapeptide of gastrin, obtained by replacing each peptide bond by a "reduced peptide bond", one at a time, e.g. Boc-Trp psi (CH2NH)Leu-Asp-Phe-NH2 2, Boc-Trp-Leu psi (CH2NH) Asp-Phe-NH2 3, Boc-Trp-Leu-Asp psi (CH2NH)Phe-NH2 4, were reported.	Aspartic Acid	228-231	gastrin	Homo sapiens	68-75
3500868-8	1987	Short synthetic peptides containing the sequence Arg-Gly-Asp-Ser effectively inhibited thrombin-dependent platelet adhesion to vWf substrates but had no effect on ristocetin-dependent adhesion.	Aspartic Acid	57-60	coagulation factor II, thrombin	Homo sapiens	87-95
3500868-8	1987	Short synthetic peptides containing the sequence Arg-Gly-Asp-Ser effectively inhibited thrombin-dependent platelet adhesion to vWf substrates but had no effect on ristocetin-dependent adhesion.	Aspartic Acid	57-60	von Willebrand factor	Homo sapiens	127-130
3122823-2	1987	The active enzyme contains 227 residues, including three corresponding to the catalytic triad characteristic of serine protease (His-57, Asp-102, and Ser-195 in chymotrypsin).	Aspartic Acid	137-140	cell division cycle 34, ubiqiutin conjugating enzyme	Rattus norvegicus	112-127
3446582-2	1987	The amino acid substitution of Asp in the variant G6PD A(+) for Asn in the normal G6PD B(+) was previously found (A. Yoshida, 1967, Proc.	Aspartic Acid	31-34	glucose-6-phosphate dehydrogenase	Homo sapiens	82-86
3153465-4	1987	Follistatin is unusually cysteine-rich, containing 36 cysteines in the mature coding sequence of 315 amino acids and an extremely acidic carboxyl terminal region, FS(292-304), comprised of Glu-Asp-Thr-Glu-Glu-Glu-Glu-Glu-Asp-Glu-Asp-Gln-Asp which probably resides outside a tightly cross-linked protein sphere.	Aspartic Acid	193-196	follistatin	Homo sapiens	0-11
2889718-5	1987	To explore the function of Glu-553 we used oligonucleotide-directed mutagenesis to replace this residue with Asp in cloned ETA and expressed the mutant gene in Escherichia coli K-12.	Aspartic Acid	109-112	endothelin receptor type A	Mus musculus	123-126
2889718-6	1987	ADP-ribosylation activity of Asp-553 ETA in cell extracts was about 1,800-fold lower and toxicity for mouse L-M929 fibroblasts was at least 10,000-fold lower than that of the wild-type toxin.	Aspartic Acid	29-32	endothelin receptor type A	Mus musculus	37-40
2889718-7	1987	Extracts containing Asp-553 ETA inhibited the cytotoxicity of authentic ETA on L-M929 fibroblasts, suggesting that the mutant toxin competes for ETA receptors.	Aspartic Acid	20-23	endothelin receptor type A	Mus musculus	28-31
2889718-7	1987	Extracts containing Asp-553 ETA inhibited the cytotoxicity of authentic ETA on L-M929 fibroblasts, suggesting that the mutant toxin competes for ETA receptors.	Aspartic Acid	20-23	endothelin receptor type A	Mus musculus	72-75
2889718-7	1987	Extracts containing Asp-553 ETA inhibited the cytotoxicity of authentic ETA on L-M929 fibroblasts, suggesting that the mutant toxin competes for ETA receptors.	Aspartic Acid	20-23	endothelin receptor type A	Mus musculus	72-75
3153465-4	1987	Follistatin is unusually cysteine-rich, containing 36 cysteines in the mature coding sequence of 315 amino acids and an extremely acidic carboxyl terminal region, FS(292-304), comprised of Glu-Asp-Thr-Glu-Glu-Glu-Glu-Glu-Asp-Glu-Asp-Gln-Asp which probably resides outside a tightly cross-linked protein sphere.	Aspartic Acid	221-224	follistatin	Homo sapiens	0-11
3153465-4	1987	Follistatin is unusually cysteine-rich, containing 36 cysteines in the mature coding sequence of 315 amino acids and an extremely acidic carboxyl terminal region, FS(292-304), comprised of Glu-Asp-Thr-Glu-Glu-Glu-Glu-Glu-Asp-Glu-Asp-Gln-Asp which probably resides outside a tightly cross-linked protein sphere.	Aspartic Acid	221-224	follistatin	Homo sapiens	0-11
3153465-4	1987	Follistatin is unusually cysteine-rich, containing 36 cysteines in the mature coding sequence of 315 amino acids and an extremely acidic carboxyl terminal region, FS(292-304), comprised of Glu-Asp-Thr-Glu-Glu-Glu-Glu-Glu-Asp-Glu-Asp-Gln-Asp which probably resides outside a tightly cross-linked protein sphere.	Aspartic Acid	221-224	follistatin	Homo sapiens	0-11
3509344-1	1987	Our previous work on the effect of modification of peptide bonds in gastrin-like peptides led us to speculate that cleavage of the bond between the Met and Asp residues occurs in gastric mucosal membranes, and that this cleavage may have functional significance.	Aspartic Acid	156-159	gastrin	Rattus norvegicus	68-75
3435944-0	1987	Reactivities of various amines in the modifications of acetic acid and aspartic acid-101 of lysozyme in the carbodiimide reaction.	Aspartic Acid	71-84	lysozyme	Homo sapiens	92-100
3325498-9	1987	This report presents evidence that in cells containing a large amount of the fumarate reductase, the production of succinate from glucose is regulated by the cellular level of aspartate through the pyruvate carboxylase reaction and that glutamate regulates the succinate production by a mechanism distinct from that involved in the regulation by L-aspartate.	Aspartic Acid	176-185	fumarate reductase	Saccharomyces cerevisiae S288C	77-95
3325498-9	1987	This report presents evidence that in cells containing a large amount of the fumarate reductase, the production of succinate from glucose is regulated by the cellular level of aspartate through the pyruvate carboxylase reaction and that glutamate regulates the succinate production by a mechanism distinct from that involved in the regulation by L-aspartate.	Aspartic Acid	346-357	fumarate reductase	Saccharomyces cerevisiae S288C	77-95
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Aspartic Acid	198-201	interleukin 1 alpha	Homo sapiens	60-70
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Aspartic Acid	198-201	interleukin 1 alpha	Homo sapiens	177-187
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Aspartic Acid	127-130	fibronectin 1	Mus musculus	15-26
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Aspartic Acid	127-130	fibronectin 1	Mus musculus	178-189
2957232-5	1987	It is monomeric with a tendency to dimerize and appears to be distinct from the cell surface fibronectin receptors which interact with the Arg-Gly-Asp recognition site in the fibronectin molecule.	Aspartic Acid	147-150	fibronectin 1	Homo sapiens	93-104
2957232-5	1987	It is monomeric with a tendency to dimerize and appears to be distinct from the cell surface fibronectin receptors which interact with the Arg-Gly-Asp recognition site in the fibronectin molecule.	Aspartic Acid	147-150	fibronectin 1	Homo sapiens	175-186
3306677-0	1987	A superactive insulin: [B10-aspartic acid]insulin(human).	Aspartic Acid	28-41	insulin	Homo sapiens	14-21
2443507-1	1987	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Aspartic Acid	114-117	GRDX	Homo sapiens	32-35
2443507-1	1987	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Aspartic Acid	114-117	fibronectin 1	Homo sapiens	148-159
2443507-1	1987	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Aspartic Acid	114-117	vitronectin	Homo sapiens	164-175
2443507-2	1987	This report demonstrates that human melanoma cells (M21) synthesize and express a glycoprotein receptor that shares antigenic epitopes with the vitronectin receptor on human fibroblasts and is capable of specifically recognizing the Gly-Arg-Gly-Asp-Ser-Pro sequence.	Aspartic Acid	245-248	vitronectin	Homo sapiens	144-155
2443508-0	1987	Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor.	Aspartic Acid	63-66	fibronectin 1	Homo sapiens	102-113
2443508-2	1987	Cells capable of attachment and growth in 5-mM concentrations of a peptide having the sequence Gly-Arg-Gly-Asp-Ser-Pro overproduce the cell surface receptor for fibronectin.	Aspartic Acid	107-110	fibronectin 1	Homo sapiens	161-172
2443508-4	1987	In agreement with the resistance of the selected cells to detachment by the peptide, 25-fold more Arg-Gly-Asp-containing peptide is required to prevent the attachment of these cells to fibronectin-coated surfaces than is needed to inhibit the attachment of MG-63 cells to the same substrate.	Aspartic Acid	106-109	fibronectin 1	Homo sapiens	185-196
3305797-6	1987	Staining by Asp1 and Asp2 was also inhibited by free small molecules containing aspartate.	Aspartic Acid	80-89	beta-secretase 1	Rattus norvegicus	21-25
3305797-8	1987	In all 3 types of assays, Asp1 and Asp2 displayed strong reactivity for small molecules and conjugates containing aspartate and little reactivity for small molecules and conjugates containing glutamate or GABA.	Aspartic Acid	114-123	beta-secretase 1	Rattus norvegicus	35-39
3302105-7	1987	The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- .	Aspartic Acid	58-61	colony stimulating factor 2	Canis lupus familiaris	38-41
3302105-7	1987	The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- .	Aspartic Acid	58-61	angiotensinogen	Canis lupus familiaris	48-53
3480361-9	1987	From the above results, CS, as a dehydropeptidase-I inhibitor apparently caused increases in some peptides consisting mainly of Asp, Glu, Gly and Ala in patients with impaired renal function.	Aspartic Acid	128-131	dipeptidase 1	Homo sapiens	33-51
2442758-2	1987	This complex can be isolated in pure form from an affinity matrix consisting of an Arg-Gly-Asp-containing heptapeptide and is specifically immunoprecipitated with monoclonal antibodies (mAbs) directed against the vitronectin receptor of human melanoma cells.	Aspartic Acid	91-94	vitronectin	Homo sapiens	213-224
3306677-0	1987	A superactive insulin: [B10-aspartic acid]insulin(human).	Aspartic Acid	28-41	insulin	Homo sapiens	42-49
2441703-0	1987	Differential racemization of aspartate and serine in human myelin basic protein.	Aspartic Acid	29-38	myelin basic protein	Homo sapiens	59-79
2441703-1	1987	L-Aspartate and L-serine were found to undergo amino acid racemization in brain myelin basic protein (MBP) of aging humans.	Aspartic Acid	0-11	myelin basic protein	Homo sapiens	80-100
2464379-6	1987	The synthetic hPTH 1-84 (Asp 76) also behaved similarly in the amino- and both mid-region-specific assays but was markedly less reactive in the carboxy-region-specific assay.	Aspartic Acid	25-28	parathyroid hormone	Homo sapiens	14-20
2441703-1	1987	L-Aspartate and L-serine were found to undergo amino acid racemization in brain myelin basic protein (MBP) of aging humans.	Aspartic Acid	0-11	myelin basic protein	Homo sapiens	102-105
3627975-3	1987	The polymerase chain reaction with Ki-ras specific amplimers revealed a guanosine to adenosine transition at the second position of codon 13, resulting in a substitution of glycine by aspartic acid.	Aspartic Acid	184-197	KRAS proto-oncogene, GTPase	Homo sapiens	35-41
2440809-8	1987	Moreover, the binding of S protein to G streptococci could be partially by the synthetic peptide Gly-Arg-Gly-Asp-Ser, which contains the cell attachment site of S protein.	Aspartic Acid	109-112	vitronectin	Homo sapiens	25-34
3652906-4	1987	Three substitutions are within the predicted rat IGF-I sequence: a Pro for Asp in the B domain, an Ile for Ser in the C domain, and Thr for Ala in the D domain.	Aspartic Acid	75-78	insulin-like growth factor 1	Rattus norvegicus	49-54
2440809-8	1987	Moreover, the binding of S protein to G streptococci could be partially by the synthetic peptide Gly-Arg-Gly-Asp-Ser, which contains the cell attachment site of S protein.	Aspartic Acid	109-112	vitronectin	Homo sapiens	161-170
2440809-11	1987	The binding to group G streptococci, S. aureus, and E. coli is mediated in part through a domain in the S protein containing the sequence Arg-Gly-Asp, whereas a different site is responsible for the binding to group A and C streptococci.	Aspartic Acid	146-149	vitronectin	Homo sapiens	104-113
2897102-3	1987	Sequencing of the mutant v-erbB gene revealed a single amino acid change of a histidine to an aspartate residue at a position equivalent to amino-acid 826 of the human epidermal growth factor receptor.	Aspartic Acid	94-103	epidermal growth factor receptor	Homo sapiens	168-200
3109484-6	1987	Similarly, Lys-220 (NH3+) of chymosin and a Glu (COO-) in P2 of a substrate may produce a favorable interaction and Asp-77 (COO-) of E. parasitica proteinase and a Glu (COO-) in P2 of a substrate may produce an unfavorable interaction.	Aspartic Acid	116-119	chymosin	Bos taurus	29-37
3597437-3	1987	Bone proteoglycan II is 95% N terminally blocked and the small amount that can be sequenced has an amino-terminal sequence (NH2-Asp-Glu-Ala-()-Gly-Ile.	Aspartic Acid	128-131	decorin	Homo sapiens	0-20
3036276-1	1987	Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain.	Aspartic Acid	32-35	fibrinogen beta chain	Homo sapiens	6-16
3036276-1	1987	Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain.	Aspartic Acid	32-35	ral guanine nucleotide dissociation stimulator	Homo sapiens	41-45
3295120-6	1987	Pretreatment of rats with 2-APH significantly reversed the insulin-induced changes in striatal aspartate, glutamate, and glutamine levels, especially in the intact hemisphere.	Aspartic Acid	95-104	acylaminoacyl-peptide hydrolase	Rattus norvegicus	28-31
3295120-8	1987	2-APH had no effect on the level of "metabolic" aspartate in the striata of normoglycemic rats but caused an almost complete suppression of "synaptic" aspartate.	Aspartic Acid	151-160	acylaminoacyl-peptide hydrolase	Rattus norvegicus	2-5
3295120-10	1987	The insulin-induced rise in "synaptic" aspartate level was almost completely blocked by 2-APH (a 5% rise instead of a 3.5-fold rise).	Aspartic Acid	39-48	acylaminoacyl-peptide hydrolase	Rattus norvegicus	90-93
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Aspartic Acid	143-146	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
3109489-9	1987	These studies indicated that the amino acids present in the active site of glyoxalase I from intestinal mucosa which may be important for activity are tyrosine, tryptophan, lysine and glutamic acid/aspartic acid residues.	Aspartic Acid	198-211	glyoxalase I	Homo sapiens	75-87
2956269-4	1987	The RGDS tetrapeptide (arg-gly-asp-ser) from the cell attachment domain of fibronectin can specifically block attachment and outgrowth on both fibronectin- and laminin-coated substrates.	Aspartic Acid	31-34	ral guanine nucleotide dissociation stimulator	Homo sapiens	4-8
2956269-4	1987	The RGDS tetrapeptide (arg-gly-asp-ser) from the cell attachment domain of fibronectin can specifically block attachment and outgrowth on both fibronectin- and laminin-coated substrates.	Aspartic Acid	31-34	fibronectin 1	Homo sapiens	75-86
2956269-4	1987	The RGDS tetrapeptide (arg-gly-asp-ser) from the cell attachment domain of fibronectin can specifically block attachment and outgrowth on both fibronectin- and laminin-coated substrates.	Aspartic Acid	31-34	fibronectin 1	Homo sapiens	143-154
2956270-2	1987	Whereas the Ba F3 cell line, which has both immunoglobulin heavy- and light-chain genes in germline configuration, interacts with the arg-gly-asp-containing cell-binding domain of fibronectin, the B-committed line PD 31, which is undergoing rearrangement of immunoglobulin light-chain genes, does not.	Aspartic Acid	142-145	fibronectin 1	Mus musculus	180-191
3037525-10	1987	We have observed that [Met]enkephalin strongly antagonizes the action of the naturally occurring peripherally active CCK-8 (CCK-7 with an NH2-terminal aspartic acid residue added).	Aspartic Acid	151-164	cholecystokinin	Homo sapiens	117-120
3037525-10	1987	We have observed that [Met]enkephalin strongly antagonizes the action of the naturally occurring peripherally active CCK-8 (CCK-7 with an NH2-terminal aspartic acid residue added).	Aspartic Acid	151-164	cholecystokinin	Homo sapiens	124-129
3294787-11	1987	Using in vitro oligonucleotide-directed mutagenesis, we constructed a new signal sequence mutant in which Asp was substituted for Arg at the -3 position of an otherwise wild-type MBP signal peptide.	Aspartic Acid	106-109	myelin basic protein	Mus musculus	179-182
3474030-1	1987	The sizes of the radiolabeled fragments obtained by CNBr and DMSO/HBr digestion of 32P-labeled ornithine decarboxylase phosphorylated by rat liver casein kinase TS (type-2) are consistent with the location of the phosphorylation site within the sequence(303-309) Ser-Asp-Asp-Glu-Asp-Glu-Ser.	Aspartic Acid	267-270	ornithine decarboxylase 1	Rattus norvegicus	95-118
3474030-1	1987	The sizes of the radiolabeled fragments obtained by CNBr and DMSO/HBr digestion of 32P-labeled ornithine decarboxylase phosphorylated by rat liver casein kinase TS (type-2) are consistent with the location of the phosphorylation site within the sequence(303-309) Ser-Asp-Asp-Glu-Asp-Glu-Ser.	Aspartic Acid	271-274	ornithine decarboxylase 1	Rattus norvegicus	95-118
3474030-1	1987	The sizes of the radiolabeled fragments obtained by CNBr and DMSO/HBr digestion of 32P-labeled ornithine decarboxylase phosphorylated by rat liver casein kinase TS (type-2) are consistent with the location of the phosphorylation site within the sequence(303-309) Ser-Asp-Asp-Glu-Asp-Glu-Ser.	Aspartic Acid	271-274	ornithine decarboxylase 1	Rattus norvegicus	95-118
3584243-10	1987	Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Aspartic Acid	125-128	integrin subunit alpha 2b	Homo sapiens	51-56
3584243-10	1987	Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Aspartic Acid	125-128	fibrinogen beta chain	Homo sapiens	81-91
3584243-10	1987	Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Aspartic Acid	125-128	Fc gamma receptor and transporter	Homo sapiens	140-151
3037722-0	1987	Inhibition of von Willebrand factor binding to platelets by two recognition site peptides: the pentadecapeptide of the carboxy terminus of the fibrinogen gamma chain and the tetrapeptide arg-gly-asp-ser.	Aspartic Acid	195-198	von Willebrand factor	Homo sapiens	14-35
3571255-14	1987	Like the CD site in oncomodulin, site III in troponin C has not only a lower affinity for calcium relative to the CD site of parvalbumins but also aspartic acid at its -X position; a water molecule bridges the gap between bound metal and the carboxyl group of the relatively short side chain of Asp-114 (Herzberg, O.	Aspartic Acid	147-160	oncomodulin	Homo sapiens	20-31
3571255-14	1987	Like the CD site in oncomodulin, site III in troponin C has not only a lower affinity for calcium relative to the CD site of parvalbumins but also aspartic acid at its -X position; a water molecule bridges the gap between bound metal and the carboxyl group of the relatively short side chain of Asp-114 (Herzberg, O.	Aspartic Acid	295-298	oncomodulin	Homo sapiens	20-31
3571255-16	1987	Hence, we suggest that Asp-59 in oncomodulin binds metal only indirectly through an intervening water molecule, a proposal which is consistent with the CD site"s reduced affinity for ions the size of Ca(II) or smaller.	Aspartic Acid	23-26	oncomodulin	Homo sapiens	33-44
3571255-16	1987	Hence, we suggest that Asp-59 in oncomodulin binds metal only indirectly through an intervening water molecule, a proposal which is consistent with the CD site"s reduced affinity for ions the size of Ca(II) or smaller.	Aspartic Acid	23-26	carbonic anhydrase 2	Homo sapiens	200-206
3571262-1	1987	Class II actin genes usually specify a polypeptide with a Met-Cys-Asp NH2 terminus, whereas the actin itself begins with an acetyl (Ac)-Asp(Glu).	Aspartic Acid	66-69	Actin 79B	Drosophila melanogaster	9-14
3571262-2	1987	Previous studies with Drosophila actin showed that the first detectable intermediate is one with an Ac-Cys NH2 terminus which is subsequently cleaved in a novel reaction to expose the Asp.	Aspartic Acid	184-187	Actin 79B	Drosophila melanogaster	33-38
3571262-7	1987	In a time- and acetyl-CoA-dependent fashion, Met-Cys-Asp-actin was processed to the mature actin, presumably through an Ac-Met-Cys-Asp intermediate.	Aspartic Acid	53-56	Actin 79B	Drosophila melanogaster	57-62
3571262-7	1987	In a time- and acetyl-CoA-dependent fashion, Met-Cys-Asp-actin was processed to the mature actin, presumably through an Ac-Met-Cys-Asp intermediate.	Aspartic Acid	53-56	Actin 79B	Drosophila melanogaster	91-96
3576974-4	1987	Nucleic acid sequence analysis of the activated N-ras gene revealed a point mutation at codon 12 resulting in a glycine to aspartic acid substitution.	Aspartic Acid	123-136	neuroblastoma ras oncogene	Mus musculus	48-53
3612939-0	1987	The effect of magnesium aspartate, xylazine and morphine on the immobilization-induced increase in the levels of prolactin in turkey plasma.	Aspartic Acid	14-33	prolactin	Meleagris gallopavo	113-122
3612939-1	1987	The effect of pre-treating turkey poults (8 weeks old) with magnesium aspartate, xylazine or morphine on the concentration of prolactin (PRL) in plasma was studied in normal birds, and birds stressed with immobilization.	Aspartic Acid	60-79	prolactin	Meleagris gallopavo	126-135
3038148-0	1987	The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analysis.	Aspartic Acid	82-95	kallikrein 1-related peptidase C2	Rattus norvegicus	59-64
3038148-1	1987	The revised amino acid sequence of rat submaxillary gland tonin, a serine protease, does contain the active site Asp residue.	Aspartic Acid	113-116	kallikrein 1-related peptidase C2	Rattus norvegicus	58-63
3038148-3	1987	The important Asp residue has now been localized in a 16 amino acid peptide previously reported as missing in the tonin sequence.	Aspartic Acid	14-17	kallikrein 1-related peptidase C2	Rattus norvegicus	114-119
3470784-9	1987	Sequence analysis of lambda MD41, however, revealed a single nucleotide substitution in the codon for residue 10 of proinsulin (CAC----GAC) that predicts the exchange of aspartic acid for histidine in the insulin B chain region.	Aspartic Acid	170-183	insulin	Homo sapiens	116-126
2435739-12	1987	The carboxy terminus of CENP-B contains two long domains comprised almost entirely of glutamic and aspartic acid residues.	Aspartic Acid	99-112	centromere protein B	Homo sapiens	24-30
3453895-7	1987	Unlike the human and porcine sequences, rat preprogastrin contains a 9 amino acid carboxy-terminal extension peptide (-Ser-Ala-Glu-Glu-Glu-Asp-Gln-Tyr-Asn) which is homologous to the midportion of gastrin 17 including the site of tyrosine sulfation.	Aspartic Acid	139-142	gastrin	Homo sapiens	50-57
3470784-9	1987	Sequence analysis of lambda MD41, however, revealed a single nucleotide substitution in the codon for residue 10 of proinsulin (CAC----GAC) that predicts the exchange of aspartic acid for histidine in the insulin B chain region.	Aspartic Acid	170-183	insulin	Homo sapiens	119-126
3469204-2	1987	The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen.	Aspartic Acid	82-85	fibronectin 1	Homo sapiens	144-155
3814824-1	1987	The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding.	Aspartic Acid	32-35	fibrinogen beta chain	Homo sapiens	48-58
3814824-1	1987	The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding.	Aspartic Acid	265-268	fibrinogen beta chain	Homo sapiens	48-58
2950119-0	1987	The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.	Aspartic Acid	49-52	fibronectin 1	Mus musculus	4-15
2950119-2	1987	To determine if the minimum cellular adhesion receptor recognition signal Arg-Gly-Asp-Ser (RGDS) is sufficient to promote FC and MFB formation, rat (NRK), hamster (Nil 8), and mouse (Balb/c 3T3) fibroblasts in serum-free media were plated on substrates derivatized with small synthetic peptides containing RGDS.	Aspartic Acid	82-85	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	91-95
3563885-7	1987	However, increased release of aspartate was noted in the 45% BCAA group compared with the 25% BCAA group.	Aspartic Acid	30-39	AT-rich interaction domain 4B	Homo sapiens	61-65
3580173-1	1987	The present work describes the purification from rat heart of the mitochondrial and cytosolic forms of the enzymes of the malate--aspartate shuttle, aspartate aminotransferase (EC 2.6.1.1) and malate dehydrogenase (EC 1.1.1.37), by a single procedure after the preparation of the original crude extract.	Aspartic Acid	130-139	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	149-175
3469204-2	1987	The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen.	Aspartic Acid	82-85	vitronectin	Homo sapiens	157-168
3469204-2	1987	The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen.	Aspartic Acid	82-85	fibrinogen beta chain	Homo sapiens	170-180
3332992-5	1987	From affinity chromatographic experiments, we have shown that the enzymes of the citric acid cycle and the aspartate-malate shuttle are organized as one huge multi-enzyme complex, and a stoichiometric arrangement of fumarase/malate dehydrogenase/citrate synthase/aspartate aminotransferase has been postulated.	Aspartic Acid	107-116	fumarate hydratase	Homo sapiens	216-224
3295483-6	1987	Two different mutations were introduced by site-specific mutagenesis in this hlyA domain: one by an exchange of ala, val to asp, glu (positions 313, 314) altering the hydrophobicity of this region and another which removes most of this hydrophobic portion.	Aspartic Acid	124-127	hemolysin transport protein	Escherichia coli	77-81
2879893-3	1987	The absence of Mg2+ also potentiates the action of exogenously applied N-methyl-D-aspartate (NMDA), L-glutamate, L-aspartate, and kainate.	Aspartic Acid	113-124	mucin 7, secreted	Homo sapiens	15-18
3818601-3	1987	At the amino acid level, this mutation results in the substitution of an aspartic acid residue for a conserved glycine at position 231 of cytochrome b.	Aspartic Acid	73-86	mitochondrially encoded cytochrome b	Homo sapiens	138-150
3614211-2	1987	Complete sequence information for the nucleotides coding for amino acids 136-163 demonstrates an A----C alteration at the codon for amino acid 152, changing Asp (GAT) in Kk to Ala (GCT) in Kkml.	Aspartic Acid	157-160	glycine-N-acyltransferase	Mus musculus	162-165
2882447-3	1987	Intrathecal injections of L-glutamate and L-aspartate elevate glycogen phosphorylase activity in the dorsal horn, while substance P has no effect and only high doses of adenosine triphosphate (ATP) increase the enzyme activity.	Aspartic Acid	42-53	glycogen phosphorylase L	Rattus norvegicus	62-84
3332992-5	1987	From affinity chromatographic experiments, we have shown that the enzymes of the citric acid cycle and the aspartate-malate shuttle are organized as one huge multi-enzyme complex, and a stoichiometric arrangement of fumarase/malate dehydrogenase/citrate synthase/aspartate aminotransferase has been postulated.	Aspartic Acid	107-116	malic enzyme 1	Homo sapiens	225-245
3332992-5	1987	From affinity chromatographic experiments, we have shown that the enzymes of the citric acid cycle and the aspartate-malate shuttle are organized as one huge multi-enzyme complex, and a stoichiometric arrangement of fumarase/malate dehydrogenase/citrate synthase/aspartate aminotransferase has been postulated.	Aspartic Acid	107-116	citrate synthase	Homo sapiens	246-262
3667323-0	1987	Hb Sassari or alpha (2)126(H9)Asp---His beta 2 observed in a family from Northern Sardinia.	Aspartic Acid	30-33	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	40-46
2885148-7	1987	However, the insect binding site was much more stereoselective for the L than D isomers of glutamate and aspartate, while the rat brain site was more stereoselective for APB.	Aspartic Acid	105-114	arginyl aminopeptidase	Rattus norvegicus	170-173
3805128-6	1987	For inhibiting interactions with laminin or native type I collagen gels, Gly-Arg-Gly-Asp-Ser was only weakly active, but the inverted peptide Ser-Asp-Gly-Arg unexpectedly continued to display inhibitory activity for both attachment proteins in both cell types.	Aspartic Acid	85-88	laminin, beta 2 (laminin S)	Gallus gallus	33-40
2878977-0	1987	Rapid inactivation of brain glutamate decarboxylase by aspartate.	Aspartic Acid	55-64	glutamate-ammonia ligase	Homo sapiens	28-51
2878977-1	1987	In the absence of its cofactor, pyridoxal 5"-phosphate (pyridoxal-P), glutamate decarboxylase is rapidly inactivated by aspartate.	Aspartic Acid	120-129	glutamate-ammonia ligase	Homo sapiens	70-93
20501118-2	1987	As enkephalinase cleaved CCK-8 at the Gly(4)-Trp(5), Trp(5)-Met(6) and Asp(7)-Phe(8) bonds, we investigated the stability of analogues having: (1) substitutions of l amino acids by a d stereoisomer, (2) a substitution of Asp(7) by a ?	Aspartic Acid	71-74	cholecystokinin	Homo sapiens	25-28
3550423-1	1987	We characterized the normal (Gly-12) and two mutant (Asp-12 and Val-12) forms of human N-ras proteins produced by Escherichia coli.	Aspartic Acid	53-56	NRAS proto-oncogene, GTPase	Homo sapiens	87-92
20501118-2	1987	As enkephalinase cleaved CCK-8 at the Gly(4)-Trp(5), Trp(5)-Met(6) and Asp(7)-Phe(8) bonds, we investigated the stability of analogues having: (1) substitutions of l amino acids by a d stereoisomer, (2) a substitution of Asp(7) by a ?	Aspartic Acid	221-224	cholecystokinin	Homo sapiens	25-28
3569692-1	1986	The in vivo and in vitro effects of a hypoglycaemic fragment of human growth hormone containing the sequence H2N-Ile-Pro-Leu-Ser-Arg-Leu-Phe-Asp-Asn-Ala-Met-Leu-COOH (hGH 4-15) on 2-deoxy-[1-14C]-D-glucose uptake in adipocytes were studied.	Aspartic Acid	141-144	growth hormone 1	Homo sapiens	70-84
2881781-2	1986	The predicted en protein contains a homeodomain and regions rich in polyalanine, polyglutamine, polyglutamate/aspartate and serine.	Aspartic Acid	110-119	engrailed	Drosophila melanogaster	14-16
2432397-4	1986	We found that the change from Thr to Ile at position 338 or the replacement of a fragment of c-src containing Gly-63, Arg-95, and Thr-96 with a corresponding fragment of v-src containing Asp-63, Trp-95, and Ile-96 converted p60c-src into a transforming protein by the criteria of focus formation, anchorage-independent growth, and tumor formation in newborn chickens.	Aspartic Acid	187-190	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	172-175
2432921-3	1986	Cleavage of radiomethylated 70-kilodalton (kDa) DAF with papain released the labeled ethanolamine and glucosamine and generated 61- and 55-kDa DAF products that retained all labeled Lys and labeled N-terminal Asp.	Aspartic Acid	209-212	CD55 molecule (Cromer blood group)	Homo sapiens	48-51
3024151-0	1986	Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.	Aspartic Acid	93-96	cysteine-rich secretory protein 3	Rattus norvegicus	42-54
3024151-0	1986	Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.	Aspartic Acid	93-96	secreted phosphoprotein 1	Rattus norvegicus	56-67
3024151-5	1986	An interesting observation is the Gly-Arg-Gly-Asp-Ser sequence, which is identical to the cell-binding sequence identified in fibronectin.	Aspartic Acid	46-49	fibronectin 1	Rattus norvegicus	126-137
3024151-8	1986	We could demonstrate that synthetic Arg-Gly-Asp-containing peptides efficiently inhibited the attachment of cells to sialoprotein-coated substrates.	Aspartic Acid	44-47	cysteine-rich secretory protein 3	Rattus norvegicus	117-129
3024151-9	1986	The results show that the Arg-Gly-Asp sequence also confers cell-binding properties on bone-specific sialoprotein.	Aspartic Acid	34-37	cysteine-rich secretory protein 3	Rattus norvegicus	101-113
3466166-4	1986	The presence of an initiator codon immediately preceding the codon for the NH2-terminal serine residue and of a terminator codon immediately following the codon for Asp-109, the COOH-terminal residue, suggests that prothymosin alpha is synthesized without formation of a larger precursor polypeptide.	Aspartic Acid	165-168	prothymosin alpha pseudogene 9	Homo sapiens	215-232
2879556-0	1986	Reaction energetics of a mutant triosephosphate isomerase in which the active-site glutamate has been changed to aspartate.	Aspartic Acid	113-122	triosephosphate isomerase 1	Gallus gallus	32-57
3023389-7	1986	The synthetic peptide Gly-Arg-Gly-Asp-Ser derived from the sequence of the cell-binding region of fibronectin could also prevent the organization of fibronectin-140K linkage complexes.	Aspartic Acid	34-37	fibronectin 1	Gallus gallus	98-109
3023389-7	1986	The synthetic peptide Gly-Arg-Gly-Asp-Ser derived from the sequence of the cell-binding region of fibronectin could also prevent the organization of fibronectin-140K linkage complexes.	Aspartic Acid	34-37	fibronectin 1	Gallus gallus	149-160
2430295-1	1986	Cells adhere to vitronectin substrates through a cell surface receptor that recognizes an Arg-Gly-Asp sequence in vitronectin.	Aspartic Acid	98-101	vitronectin	Homo sapiens	16-27
3783582-1	1986	A series of phenethyl ester derivative analogues of the C-terminal tetrapeptide of gastrin, in which the phenylalanyl residue has been replaced by a phenethyl group and the peptide bond between aspartic acid and phenylalanine by an ester bond, were synthesized.	Aspartic Acid	194-207	gastrin	Rattus norvegicus	83-90
3024185-3	1986	The chronic administration of L-aspartic acid (ASP) during the development of physical dependence or just before the N injection prevented the increase of the plasma cortisol caused by N. It is concluded that in addition to the inhibition of the brain L-asparaginase activity which was previously hypothesized to be the main reason of the development of physical dependence on opiates as a result of the related experimental and clinical data, the inhibition by M of the brain ACE activity may take part in the development of physical dependence.	Aspartic Acid	30-45	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	252-266
3024185-3	1986	The chronic administration of L-aspartic acid (ASP) during the development of physical dependence or just before the N injection prevented the increase of the plasma cortisol caused by N. It is concluded that in addition to the inhibition of the brain L-asparaginase activity which was previously hypothesized to be the main reason of the development of physical dependence on opiates as a result of the related experimental and clinical data, the inhibition by M of the brain ACE activity may take part in the development of physical dependence.	Aspartic Acid	30-45	angiotensin I converting enzyme	Rattus norvegicus	477-480
3024185-3	1986	The chronic administration of L-aspartic acid (ASP) during the development of physical dependence or just before the N injection prevented the increase of the plasma cortisol caused by N. It is concluded that in addition to the inhibition of the brain L-asparaginase activity which was previously hypothesized to be the main reason of the development of physical dependence on opiates as a result of the related experimental and clinical data, the inhibition by M of the brain ACE activity may take part in the development of physical dependence.	Aspartic Acid	47-50	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	252-266
2430295-1	1986	Cells adhere to vitronectin substrates through a cell surface receptor that recognizes an Arg-Gly-Asp sequence in vitronectin.	Aspartic Acid	98-101	vitronectin	Homo sapiens	114-125
3024185-3	1986	The chronic administration of L-aspartic acid (ASP) during the development of physical dependence or just before the N injection prevented the increase of the plasma cortisol caused by N. It is concluded that in addition to the inhibition of the brain L-asparaginase activity which was previously hypothesized to be the main reason of the development of physical dependence on opiates as a result of the related experimental and clinical data, the inhibition by M of the brain ACE activity may take part in the development of physical dependence.	Aspartic Acid	47-50	angiotensin I converting enzyme	Rattus norvegicus	477-480
3771519-7	1986	Thus, specific 125I-fibronectin binding was inhibited by excess unlabeled fibrinogen or fibronectin, the anti-GP IIb-IIIa monoclonal antibody 10E5, the decapeptide from the carboxyl terminus of the fibrinogen gamma-chain, and the tetrapeptide Arg-Gly-Asp-Ser from the cell-binding domain of fibronectin.	Aspartic Acid	251-254	fibronectin 1	Homo sapiens	20-31
2876430-5	1986	The glutamate-to-aspartate substitution results in a thermolabile enzyme as demonstrated by assays of TPI activity in cultured fibroblasts of each patient and cultured Chinese hamster ovary (CHO) cells that were stably transformed with the mutant alleles.	Aspartic Acid	17-26	triosephosphate isomerase 1	Homo sapiens	102-105
3532956-9	1986	Human prothymosin alpha also differs from rat prothymosin alpha at positions corresponding to residues 87, 92, and 102 of the latter, with substitutions of alanine for proline, alanine for valine, and aspartic acid for glutamic acid, respectively.	Aspartic Acid	201-214	prothymosin alpha pseudogene 9	Homo sapiens	6-23
3489715-3	1986	Proton NMR studies indicate that the overall structure of mouse epidermal growth factor is retained in the protein devoid of the COOH-terminal pentapeptide, while subsequent cleavage of the peptide bond between Arg-45 and Asp-46 starts to perturb the proton resonances most characteristic of the tertiary structure of the hormone, especially those from the aromatic ring protons of Tyr-37.	Aspartic Acid	222-225	epidermal growth factor	Mus musculus	64-87
3790514-7	1986	Since EDC cross-links Lys residue with Asp or Glu residue only when they are in direct contact, the result indicates that some of the N-terminal residues 1-12 and the C-terminal residues 357-375 of actin participate in binding depactin.	Aspartic Acid	39-42	actin	Oryctolagus cuniculus	198-203
2430952-5	1986	The N-terminal 9 amino acid sequence of soybean beta-amylase was deduced to be acetyl-Ala-Thr-Ser-Asp-Ser-Asn-Met-(Gly-Leu) from the results of sequence analysis of Pep-4 and amino acid analysis of other acidic peptides.	Aspartic Acid	98-101	beta-amylase	Glycine max	48-60
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Aspartic Acid	192-195	fibronectin 1	Mus musculus	61-72
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Aspartic Acid	192-195	fibronectin 1	Mus musculus	253-264
2428041-8	1986	Vitronectin, another adhesion molecule that apparently binds to cells via a cell surface receptor that recognizes Arg-Gly-Asp sequences, also was capable of supporting trophoblast outgrowth.	Aspartic Acid	122-125	vitronectin	Mus musculus	0-11
2428041-9	1986	These findings suggest that differentiation of cells of the trophectoderm into trophoblast cells with an invasive phenotype may involve the production of cell surface receptors for fibronectin and possibly for other proteins that contain the Arg-Gly-Asp recognition sequence.	Aspartic Acid	250-253	fibronectin 1	Mus musculus	181-192
3800911-7	1986	Glucose production from glycerate was much less sensitive to the presence of 3-MPA than was glucose production from aspartate, illustrating a phosphoenolpyruvate carboxykinase (PEPCK)-independent pathway for the cycling of pyruvate.	Aspartic Acid	116-125	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	142-175
3800911-7	1986	Glucose production from glycerate was much less sensitive to the presence of 3-MPA than was glucose production from aspartate, illustrating a phosphoenolpyruvate carboxykinase (PEPCK)-independent pathway for the cycling of pyruvate.	Aspartic Acid	116-125	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	177-182
3800911-9	1986	These data allow for an estimation of the rate of pyruvate formation from aspartate of about 1 mumol/min per kidney under conditions of complete PEPCK inhibition.	Aspartic Acid	74-83	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	145-150
2942550-8	1986	Finally, the tetrapeptide Arg-Gly-Asp-Ser, which corresponds to the fibronectin sequence recognized by fibroblastic cells, specifically and competitively inhibited attachment of hemopoietic cells to this molecule.	Aspartic Acid	34-37	fibronectin 1	Mus musculus	68-79
3018735-3	1986	The mitogenic fibrinogen receptor is not recognized by antibodies specific for the platelet fibrinogen receptor or is not competitively blocked by synthetic peptides containing the Arg-Gly-Asp sequence, which is common to fibronectin, fibrinogen, vitronectin, and other cell-attachment proteins.	Aspartic Acid	189-192	fibrinogen beta chain	Homo sapiens	14-24
3016716-1	1986	We have constructed synthetic peptides modeled on the sequences of (i) Arg-Gly-Asp, present in fibrinogen, fibronectin, and von Willebrand factor, and of (ii) the fibrinogen gamma chain (gamma 400-411) His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val.	Aspartic Acid	79-82	fibrinogen beta chain	Homo sapiens	95-105
2941419-3	1986	The eight amino acids adjacent to the tryptic digestion site form a torus with two carboxylic side chains of one aspartic and one glutamic acid for the fast twitch skeletal ATPase and two aspartic acids for the slow twitch/cardiac ATPase toward the inside.	Aspartic Acid	188-202	dynein axonemal heavy chain 8	Homo sapiens	231-237
2942111-3	1986	In addition, both of the two Asp residues occur at the end of homologous nonapeptide regions common to all of the five human plasminogen and two bovine prothrombin kringles, indicating evolutionary conservation to preserve biologically critical conformations.	Aspartic Acid	29-32	coagulation factor II, thrombin	Bos taurus	152-163
3523256-5	1986	When the aspartate residues at the first and sixth Ca2+ coordination positions are replaced by uncharged alanines, the light chains have a reduced Ca2+ binding capacity but still bind to scallop myosin with high affinity.	Aspartic Acid	9-18	myosin, heavy chain 15	Gallus gallus	195-201
3524673-12	1986	The protein also contains the tetrapeptide sequence Arg-Gly-Asp-Ser (at residues 1744-1747), which may be a cell attachment site, as in fibronectin.	Aspartic Acid	60-63	fibronectin 1	Homo sapiens	136-147
3093619-17	1986	Residue 6 of mature rat apoA-II is Asp, while it is Cys in human apoA-II, and this would account for the absence of dimeric forms of rat apoA-II in plasma.	Aspartic Acid	35-38	apolipoprotein A2	Rattus norvegicus	24-31
3790092-12	1986	Exposure of calmodulin to elevated temperatures before methylation results in racemization of aspartate and/or asparagine residues, and may result in isoaspartate formation as well.	Aspartic Acid	94-103	calmodulin 1	Homo sapiens	12-22
3790092-14	1986	These results are consistent with the hypothesis that methylation of calmodulin may occur at these uncommon aspartate residues, but are not consistent with a regulatory role for the methylation reaction.	Aspartic Acid	108-117	calmodulin 1	Homo sapiens	69-79
3755681-6	1986	Interesting features of the chromogranin A structure include repeated clusters of glutamic acid residues, the occurrence of eight potential dibasic cleavage sites, six of which are located in the C-terminal domain, and the presence, in the N-terminal domain, of -Arg-Gly-Asp- (RGD), a three amino acid sequence involved in the binding of several constitutively secreted proteins to cell membranes.	Aspartic Acid	271-274	chromogranin A	Bos taurus	28-42
3725588-5	1986	Computerized analysis of the kinetics of processing indicates that tRNA Asp, tRNA Gly, tRNA Glu and tRNA His transcripts are processed in a substrate concentration-dependent manner and also reveals the existence of a common rate-limiting step, the rate constant of which is equivalent for three of the four transcripts tested.	Aspartic Acid	72-75	mitochondrially encoded tRNA glycine	Homo sapiens	67-71
2422647-5	1986	The active site residues of histidine, aspartic acid, and serine comprising the charge-relay system of typical serine proteases were found in similar positions in PA (histidine-41, aspartic acid-96, and serine-192).	Aspartic Acid	39-52	kallikrein related peptidase 3	Homo sapiens	163-165
2871134-0	1986	Regulation of neurotransmitter aspartate metabolism by glial glutamine synthetase.	Aspartic Acid	31-40	glutamate-ammonia ligase	Rattus norvegicus	61-81
3745142-6	1986	alpha 2-Plasmin inhibitor and its 65K-daltons derivative were found to have the same NH2-terminal sequence of Asn(Asp)-Gln-Glu-Gln-.	Aspartic Acid	114-117	serpin family F member 2	Homo sapiens	0-25
2422647-5	1986	The active site residues of histidine, aspartic acid, and serine comprising the charge-relay system of typical serine proteases were found in similar positions in PA (histidine-41, aspartic acid-96, and serine-192).	Aspartic Acid	181-194	kallikrein related peptidase 3	Homo sapiens	163-165
3707922-2	1986	RNase A was labeled with a nonfluorescent acceptor (2,4-dinitrophenyl) on the alpha-amino group and a fluorescent donor (ethylenediamine monoamide of 2-naphthoxyacetic acid) on a carboxyl group in the vicinity of residue 50 (75% at Glu-49 and 25% at Asp-53).	Aspartic Acid	250-253	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
3009364-3	1986	Homology searches in protein data banks revealed the presence of the peptide SDGR in the alpha 2 domain of MHC class I antigens, and a variant of RGDS, Arg-Phe-Asp-Ser (RFDS), was found highly conserved in MHC class I (alpha 1 domain) and class II antigens (beta 1 domain).	Aspartic Acid	160-163	ral guanine nucleotide dissociation stimulator	Homo sapiens	146-150
2420006-2	1986	The binding of both of these proteins to platelets is inhibited by synthetic peptides containing the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.	Aspartic Acid	118-121	fibronectin 1	Homo sapiens	170-181
2422658-2	1986	The interaction of these thymocytes with fibronectin could be inhibited by the synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro, which comprises the previously identified cell-attachment determinant of the molecule, suggesting that the cell attachment site on fibronectin is recognized by these cells.	Aspartic Acid	109-112	fibronectin 1	Homo sapiens	41-52
2422658-2	1986	The interaction of these thymocytes with fibronectin could be inhibited by the synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro, which comprises the previously identified cell-attachment determinant of the molecule, suggesting that the cell attachment site on fibronectin is recognized by these cells.	Aspartic Acid	109-112	fibronectin 1	Homo sapiens	253-264
2420006-3	1986	An affinity matrix made of an insolubilized heptapeptide containing the Arg-Gly-Asp sequence selectively binds the platelet membrane glycoprotein IIb/IIIa from detergent extracts of platelets.	Aspartic Acid	80-83	integrin subunit alpha 2b	Homo sapiens	115-149
2420006-2	1986	The binding of both of these proteins to platelets is inhibited by synthetic peptides containing the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.	Aspartic Acid	118-121	fibrinogen beta chain	Homo sapiens	224-234
2420006-5	1986	This platelet receptor is related to the previously identified fibronectin and vitronectin receptors in that it recognizes an Arg-Gly-Asp sequence but differs from the other receptors in its wider specificity toward various adhesive proteins.	Aspartic Acid	134-137	fibronectin 1	Homo sapiens	63-74
2420006-5	1986	This platelet receptor is related to the previously identified fibronectin and vitronectin receptors in that it recognizes an Arg-Gly-Asp sequence but differs from the other receptors in its wider specificity toward various adhesive proteins.	Aspartic Acid	134-137	vitronectin	Homo sapiens	79-90
2423506-7	1986	The amino acid sequence from the amino terminus of the 42,000-dalton fragment is Asp/Gly-Gln/Val-?-Ile-Val-, which is almost identical to the sequence Asp-Gln-Cys-Ile-Val- located in the carboxyl terminal 1/3 of the collagen-binding domain of human fibronectin (Kornblihtt et al.	Aspartic Acid	81-84	fibronectin 1	Homo sapiens	249-260
2421767-2	1986	Anti-fibrin antibody 59D8 which had been elicited by immunization with human beta(1-7) peptide, Gly-His-Arg-Pro-Leu-Asp-Lys, binds to human and canine fibrins but not to bovine, ovine, or porcine fibrins.	Aspartic Acid	116-119	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	77-85
2423506-7	1986	The amino acid sequence from the amino terminus of the 42,000-dalton fragment is Asp/Gly-Gln/Val-?-Ile-Val-, which is almost identical to the sequence Asp-Gln-Cys-Ile-Val- located in the carboxyl terminal 1/3 of the collagen-binding domain of human fibronectin (Kornblihtt et al.	Aspartic Acid	151-154	fibronectin 1	Homo sapiens	249-260
2935541-4	1986	Both MEL cells and reticulocytes attached to the same site on fibronectin as do fibroblasts since adhesion of erythroid cells to fibronectin was specifically blocked by a monoclonal antibody directed against the cell-binding fragment of fibronectin and by a synthetic peptide containing the Arg-Gly-Asp-Ser sequence found in the cell-binding fragment of fibronectin.	Aspartic Acid	299-302	fibronectin 1	Homo sapiens	129-140
3012323-4	1986	It was shown that the number of Asp, Glu and His residues on the surface of Fc is about twice as many as that of Fab.	Aspartic Acid	32-35	FA complementation group B	Homo sapiens	113-116
2935541-4	1986	Both MEL cells and reticulocytes attached to the same site on fibronectin as do fibroblasts since adhesion of erythroid cells to fibronectin was specifically blocked by a monoclonal antibody directed against the cell-binding fragment of fibronectin and by a synthetic peptide containing the Arg-Gly-Asp-Ser sequence found in the cell-binding fragment of fibronectin.	Aspartic Acid	299-302	fibronectin 1	Homo sapiens	129-140
2935541-4	1986	Both MEL cells and reticulocytes attached to the same site on fibronectin as do fibroblasts since adhesion of erythroid cells to fibronectin was specifically blocked by a monoclonal antibody directed against the cell-binding fragment of fibronectin and by a synthetic peptide containing the Arg-Gly-Asp-Ser sequence found in the cell-binding fragment of fibronectin.	Aspartic Acid	299-302	fibronectin 1	Homo sapiens	129-140
2881415-7	1986	Additive inhibition of aspartate accumulation by fluorocitrate and (-) hydroxyacetate shows that, in addition to the tricarboxylic acid cycle, the reaction catalysed by ATP-citrate lyase serves in the synaptosomes as another source of oxaloacetate.	Aspartic Acid	23-32	ATP citrate lyase	Rattus norvegicus	169-186
2419146-6	1986	The contractile potency of NKA and NKB remained nearly complete after removal of N-terminal tripeptide portions, i.e., His-Lys-Thr and Asp-Met-His from the native peptides, respectively.	Aspartic Acid	135-138	tachykinin-3	Cavia porcellus	35-38
2876973-3	1986	Within the cortex, somatostatin containing neurones and the large pyramidal cells, presumed to use glutamate/aspartate as transmitters, are the most severely damaged cells.	Aspartic Acid	109-118	somatostatin	Homo sapiens	19-31
2874589-1	1986	The regional distribution and cellular localization of aspartate aminotransferase (AspAT) as a glutamate and aspartate metabolizing enzyme was studied in the hippocampal formation, in dorsal root ganglia, and in superior cervical ganglia during the postnatal development of the rat.	Aspartic Acid	55-64	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	83-88
2874589-5	1986	Our data indicate that the postnatal development of high affinity uptake capacity is parallel to the increase of histochemically demonstrable AspAT activity in the hippocampal formation suggesting that the enzyme may be involved in glutamate/aspartate neurotransmitter metabolism.	Aspartic Acid	242-251	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	142-147
3812085-4	1986	The amino acid sequence of the N-terminal portion of the mitochondrial fumarase was determined by the Edman method as Ala-Gln-Gln-Asn-Phe-Glu-Ile-Pro-Asp-, but that of the cytosolic fumarase could not be determined by the Edman method, since the N-terminal amino acid was blocked.	Aspartic Acid	150-153	fumarate hydratase	Rattus norvegicus	71-79
2434059-3	1986	DDT also increases levels of excitatory amino acids glutamate (GLU) and aspartate (ASP), but the effect occurs only in the brain stem.	Aspartic Acid	72-81	D-dopachrome tautomerase	Rattus norvegicus	0-3
2434059-3	1986	DDT also increases levels of excitatory amino acids glutamate (GLU) and aspartate (ASP), but the effect occurs only in the brain stem.	Aspartic Acid	83-86	D-dopachrome tautomerase	Rattus norvegicus	0-3
3951435-2	1986	The theoretical conformational analysis of potential surfaces of Ser-195, His-57, Asp-102 and Gln-192 side chains in the active center of native beta-trypsin has been carried out.	Aspartic Acid	82-85	serine protease 1	Homo sapiens	145-157
3007933-6	1986	The mutation points were located at different positions in the RepB protein coding region (Gly to Asp for pRBHC3 and Gly to Glu for pRBHC7).	Aspartic Acid	98-101	Replication protein repB	Staphylococcus aureus	63-67
3456492-3	1986	This allowed to show the hydrolysis of the Asp-Phe bond by the neutral endopeptidase "enkephalinase", and the cleavages at the Met-Gly and Trp-Met bonds by PCMB sensitive enzymes.	Aspartic Acid	43-46	membrane metallo-endopeptidase	Rattus norvegicus	86-100
3153215-1	1986	Thirteen children with ALL and L-asp-induced alterations of the coagulation system were treated with fresh-frozen plasma and antithrombin III (AT III) concentrate.	Aspartic Acid	31-36	serpin family C member 1	Homo sapiens	125-141
20493057-5	1986	Measurements of amino acid levels in AGS rats during the course of a seizure induced by sound show increases in aspartate and glutamate content in some brain regions (including the inferior colliculus).	Aspartic Acid	112-121	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	37-40
3544447-6	1986	The AA factor (FAA) proposed is FAA = [Glutamic acid]/[( Aspartic acid] + [Alanine]) its value in fractions of non-potent inhibitory material and in kidney stone matrices is below 0.6.	Aspartic Acid	57-70	FA complementation group A	Homo sapiens	15-18
3544447-6	1986	The AA factor (FAA) proposed is FAA = [Glutamic acid]/[( Aspartic acid] + [Alanine]) its value in fractions of non-potent inhibitory material and in kidney stone matrices is below 0.6.	Aspartic Acid	57-70	FA complementation group A	Homo sapiens	32-35
3853975-6	1985	As expected, the amino acids required for catalytic activity are conserved as is the Asp residue required for the kallikrein-type specificity.	Aspartic Acid	85-88	kallikrein related peptidase 4	Homo sapiens	114-124
3002452-7	1985	In contrast, CF mucin contained a lower content of aspartate, glutamate, and glycine than that observed for the asthmatic mucin.	Aspartic Acid	51-60	LOC100508689	Homo sapiens	16-21
3877935-1	1985	The Arg-Gly-Asp sequence resides in the cell attachment region of fibronectin.	Aspartic Acid	12-15	fibronectin 1	Homo sapiens	66-77
2416632-4	1985	The amino acid composition of sea turtle PRL is similar to ovine PRL and is characterized by a high content of aspartic acid (20 residues), glutamic acid (34 residues), serine (19 residues), and leucine (24 residues).	Aspartic Acid	111-124	prolactin	Homo sapiens	41-44
3877935-2	1985	Arg-Gly-Asp-containing peptides support fibroblast attachment, inhibit fibroblast adhesion to fibronectin, and inhibit fibronectin binding to thrombin-stimulated platelets.	Aspartic Acid	8-11	fibronectin 1	Homo sapiens	94-105
3877935-2	1985	Arg-Gly-Asp-containing peptides support fibroblast attachment, inhibit fibroblast adhesion to fibronectin, and inhibit fibronectin binding to thrombin-stimulated platelets.	Aspartic Acid	8-11	fibronectin 1	Homo sapiens	119-130
3877935-2	1985	Arg-Gly-Asp-containing peptides support fibroblast attachment, inhibit fibroblast adhesion to fibronectin, and inhibit fibronectin binding to thrombin-stimulated platelets.	Aspartic Acid	8-11	coagulation factor II, thrombin	Homo sapiens	142-150
4091848-1	1985	Evidence is presented that the hypoglycemic action of the human growth hormone fragment, Ile-Pro-Leu-Ser-Arg-Leu-Phe-Asp-Asn-Ala (hGH 4-15) is due to the interaction of hGH 4-15 with plasma membrane resulting in a time- and temperature-dependent release of a cellular mediator which acts to increase insulin binding and hexose transport with consequent potentiation of insulin action.	Aspartic Acid	117-120	growth hormone 1	Homo sapiens	64-78
2866476-0	1985	Elevated concentrations of glutamate and aspartate in human ventricular cerebrospinal fluid (vCSF) during episodes of increased CSF pressure and clinical signs of impaired brain circulation.	Aspartic Acid	41-50	colony stimulating factor 2	Homo sapiens	94-97
2995350-4	1985	Moreover, the amino acid sequence Arg-Gly-Asp-Ser, corresponding to the cell attachment site of fibronectin, is located near the carboxyl-terminal region of the alpha-chain of fibrinogen.	Aspartic Acid	42-45	fibronectin 1	Homo sapiens	96-107
2995350-4	1985	Moreover, the amino acid sequence Arg-Gly-Asp-Ser, corresponding to the cell attachment site of fibronectin, is located near the carboxyl-terminal region of the alpha-chain of fibrinogen.	Aspartic Acid	42-45	fibrinogen beta chain	Homo sapiens	176-186
2414098-7	1985	An Arg-Gly-Asp sequence, which has previously been shown to be the cell attachment site in fibronectin, was found in vitronectin immediately after the NH2-terminal somatomedin B sequence.	Aspartic Acid	11-14	fibronectin 1	Homo sapiens	91-102
3876125-2	1985	The prototypical peptide gly-arg-gly-asp-ser was capable of inhibiting thrombin-induced platelet aggregation without altering the degree of platelet activation as judged by the secretion of 14C-serotonin.	Aspartic Acid	37-40	coagulation factor II, thrombin	Homo sapiens	71-79
3876125-4	1985	The smallest peptide from the cell-binding region of fibronectin which retained full activity was arg-gly-asp-ser.	Aspartic Acid	106-109	fibronectin 1	Homo sapiens	53-64
3876125-6	1985	Peptides containing the arg-gly-asp-ser sequence were also capable of inhibiting the adhesion of platelets to fibrinogen and von Willebrand factor substrates.	Aspartic Acid	32-35	fibrinogen beta chain	Homo sapiens	110-120
2414098-7	1985	An Arg-Gly-Asp sequence, which has previously been shown to be the cell attachment site in fibronectin, was found in vitronectin immediately after the NH2-terminal somatomedin B sequence.	Aspartic Acid	11-14	vitronectin	Homo sapiens	117-128
2414098-9	1985	The Arg-Gly-Asp sequence appears to constitute the cell attachment site of vitronectin, since it is in the region where we have previously localized the cell attachment site, its presence correlate with cell attachment activity among the insert-coded polypeptides, and because previous results have shown that synthetic peptides containing the Arg-Gly-Asp sequence inhibit the cell attachment function of vitronectin.	Aspartic Acid	352-355	vitronectin	Homo sapiens	75-86
2414098-9	1985	The Arg-Gly-Asp sequence appears to constitute the cell attachment site of vitronectin, since it is in the region where we have previously localized the cell attachment site, its presence correlate with cell attachment activity among the insert-coded polypeptides, and because previous results have shown that synthetic peptides containing the Arg-Gly-Asp sequence inhibit the cell attachment function of vitronectin.	Aspartic Acid	12-15	vitronectin	Homo sapiens	75-86
2414098-9	1985	The Arg-Gly-Asp sequence appears to constitute the cell attachment site of vitronectin, since it is in the region where we have previously localized the cell attachment site, its presence correlate with cell attachment activity among the insert-coded polypeptides, and because previous results have shown that synthetic peptides containing the Arg-Gly-Asp sequence inhibit the cell attachment function of vitronectin.	Aspartic Acid	12-15	vitronectin	Homo sapiens	405-416
2864688-10	1985	The tetrapeptide sequence of Arg-Gly-Asp-Ser, which mediates the cell attachment and platelet binding activity of fibronectin, was also identified in the carboxyl-terminal portion of von Willebrand factor.	Aspartic Acid	37-40	fibronectin 1	Homo sapiens	114-125
2864688-10	1985	The tetrapeptide sequence of Arg-Gly-Asp-Ser, which mediates the cell attachment and platelet binding activity of fibronectin, was also identified in the carboxyl-terminal portion of von Willebrand factor.	Aspartic Acid	37-40	von Willebrand factor	Homo sapiens	183-204
3897758-4	1985	However, the cleavage pattern differed markedly from one CCK peptide to another: in the penta- and hexapeptide of CCK the bonds hydrolyzed were either Asp-Phe and Trp-Met or, Asp-Phe and Gly-Trp, respectively.	Aspartic Acid	151-154	cholecystokinin	Rattus norvegicus	114-117
4033346-6	1985	Dog VIP was found to have the following sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala -Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn.	Aspartic Acid	58-61	vasoactive intestinal peptide	Canis lupus familiaris	4-7
3897758-4	1985	However, the cleavage pattern differed markedly from one CCK peptide to another: in the penta- and hexapeptide of CCK the bonds hydrolyzed were either Asp-Phe and Trp-Met or, Asp-Phe and Gly-Trp, respectively.	Aspartic Acid	175-178	cholecystokinin	Rattus norvegicus	114-117
2864920-3	1985	Perfusion of kidneys with aspartate in the presence of amino-oxyacetate resulted in a near-complete inhibition of aspartate metabolism, illustrating the essential role of aspartate aminotransferase in the metabolism of this substrate.	Aspartic Acid	26-35	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	171-197
4044659-6	1985	None of these four peptides contains the tetrapeptide sequence Arg-Gly-Asp-Ser, which has been associated with fibronectin-mediated cell adhesion.	Aspartic Acid	71-74	fibronectin 1	Rattus norvegicus	111-122
2412711-5	1985	From these results and data made up with the help of a computer comparison of known sequences of urokinase and a tissue-type plasminogen activator, we concluded that the epitope is Cys-Gln-Gly-Asp-Ser-Gly-Gly-Pro-Leu-Val-Cys and contains a catalytically active residue, serine.	Aspartic Acid	193-196	plasminogen activator, tissue type	Homo sapiens	113-146
4019510-4	1985	The two analogs Asp-Trp-Leu-Lys-Ala-Phe-Tyr-Asp-Lys-Val-Ala-Glu-Lys-Leu-Lys-Glu-Ala-Phe (18A) and 18A-Pro-18A whose sequences most strongly mimic native amphipathic sequences were found also most strongly to mimic apolipoprotein A-I in DMPC complex structure.	Aspartic Acid	16-19	apolipoprotein A1	Homo sapiens	214-232
2412224-0	1985	A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.	Aspartic Acid	97-110	vitronectin	Homo sapiens	49-60
2412224-0	1985	A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.	Aspartic Acid	97-110	fibronectin 1	Homo sapiens	142-153
2412224-2	1985	Detergent extracts of human osteosarcoma (MG-63) cells were chromatographed on either vitronectin-Sepharose or Sepharose linked to the synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro, which includes the fibronectin cell attachment sequence Arg-Gly-Asp.	Aspartic Acid	165-168	fibronectin 1	Homo sapiens	197-208
2412224-5	1985	In contrast, liposomes containing a previously identified 140-kDa fibronectin receptor, which interacts with the Arg-Gly-Asp sequence in fibronectin, did not bind to vitronectin.	Aspartic Acid	121-124	fibronectin 1	Homo sapiens	66-77
2412224-5	1985	In contrast, liposomes containing a previously identified 140-kDa fibronectin receptor, which interacts with the Arg-Gly-Asp sequence in fibronectin, did not bind to vitronectin.	Aspartic Acid	121-124	fibronectin 1	Homo sapiens	137-148
3160809-0	1985	Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser.	Aspartic Acid	74-77	fibronectin 1	Homo sapiens	0-11
2991265-13	1985	His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 (substance K) and bombesin are degraded by striatal but not lung ACE.	Aspartic Acid	12-15	angiotensin I converting enzyme	Rattus norvegicus	109-112
2410914-3	1985	Through examination of the binding of these analogs to monoclonal antibodies raised against residues 75-110 of HA1, it was found that a single amino acid, aspartic acid at position 101, is of unique importance to the interaction.	Aspartic Acid	155-168	Rho GTPase activating protein 45	Homo sapiens	111-114
4044552-5	1985	The N-terminal sequence of C3d-G was determined as Thr-Glu-Asp-Ala-Val-, suggesting that cathepsin G released C3d-G by cleaving a Met-Thr peptide bond which is located at 19 residues toward the N-terminal from the cysteinyl residue forming an internal thiolester linkage in native C3.	Aspartic Acid	59-62	cathepsin G	Homo sapiens	89-100
2410271-4	1985	Proinsulin and des(Ala, Asp)-insulin compete for 125I-insulin binding with 4% and 2%, respectively, of the potency of insulin.	Aspartic Acid	24-27	insulin	Homo sapiens	29-36
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Aspartic Acid	28-31	myelin basic protein	Homo sapiens	58-78
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Aspartic Acid	28-31	myelin basic protein	Homo sapiens	80-83
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Aspartic Acid	28-31	myelin basic protein	Homo sapiens	142-145
4038319-5	1985	Thus, the Asp residues are essential for the cardiac stimulatory activity of AP-A, as well as for maintaining its native conformation.	Aspartic Acid	10-13	glutamyl aminopeptidase	Homo sapiens	77-81
2408702-2	1985	The effects of iontophoretically applied serotonin, substance P or thyrotropin-releasing hormone (TRH) on glutamate or aspartate-evoked activity were then tested.	Aspartic Acid	119-128	thyrotropin releasing hormone	Rattus norvegicus	98-101
4008916-1	1985	Aspartate aminotransferase (AAT), an enzyme interconverting glutamate and aspartate, has been suggested to be a marker for glutamatergic and/or aspartatergic neurons.	Aspartic Acid	74-83	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	0-26
4008916-1	1985	Aspartate aminotransferase (AAT), an enzyme interconverting glutamate and aspartate, has been suggested to be a marker for glutamatergic and/or aspartatergic neurons.	Aspartic Acid	74-83	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	28-31
4008916-2	1985	However, AAT, glutamate, and aspartate are also involved in cellular metabolism, e.g., the malate-aspartate shuttle.	Aspartic Acid	98-107	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	9-12
2863768-2	1985	As gamma-glutamyl transpeptidase (GGT) plays a role in mediating the uptake of glutamate and aspartate into various compartments of the brain, we studied changes in the activity of this enzyme in main regions of the brain in young and adult rats.	Aspartic Acid	93-102	gamma-glutamyltransferase 1	Rattus norvegicus	3-32
2863768-2	1985	As gamma-glutamyl transpeptidase (GGT) plays a role in mediating the uptake of glutamate and aspartate into various compartments of the brain, we studied changes in the activity of this enzyme in main regions of the brain in young and adult rats.	Aspartic Acid	93-102	gamma-glutamyltransferase 1	Rattus norvegicus	34-37
4004871-1	1985	Tropoelastin and elastin preparations obtained from aortae of spontaneously hypertensive rats (SHR) show an increased proportion of polar amino acids (aspartic acid, glutamic acid, arginine and tyrosine).	Aspartic Acid	151-164	elastin	Rattus norvegicus	0-12
4004871-1	1985	Tropoelastin and elastin preparations obtained from aortae of spontaneously hypertensive rats (SHR) show an increased proportion of polar amino acids (aspartic acid, glutamic acid, arginine and tyrosine).	Aspartic Acid	151-164	elastin	Rattus norvegicus	5-12
2861809-12	1985	Maximal activities of glutaminase, glutamate dehydrogenase and aspartate aminotransferase were increased 3-, 12- and 6-fold respectively in proliferating cells; 32% of the glutamate metabolized in the citric acid cycle was recovered in CO2 and 61% in aspartate.	Aspartic Acid	63-72	glutaminase	Canis lupus familiaris	22-58
3886659-8	1985	In the course of screening a yeast DNA bank for initiator tRNA clones we have isolated and sequenced three yeast tRNA genes corresponding to glycine, alanine, and aspartic acid tRNAs.	Aspartic Acid	163-176	mitochondrially encoded tRNA glycine	Homo sapiens	58-62
3886659-8	1985	In the course of screening a yeast DNA bank for initiator tRNA clones we have isolated and sequenced three yeast tRNA genes corresponding to glycine, alanine, and aspartic acid tRNAs.	Aspartic Acid	163-176	mitochondrially encoded tRNA glycine	Homo sapiens	113-117
3906590-8	1985	This feature was exemplified by the substitution of L.Asp by D.Asp, preventing the Trp4-Nle5 cleavage, which gave rise to the most enkephalinase-resistant analog in this series.	Aspartic Acid	54-57	neprilysin	Oryctolagus cuniculus	131-144
2985590-4	1985	Our results and the results from the literature search suggest that the aminopeptidase cleaves amino-terminal methionine when it precedes residues of alanine, glycine, proline, serine, threonine, and valine but not when it precedes residues of arginine, asparagine, aspartic acid, glutamine glutamic acid, isoleucine, leucine, lysine, or methionine.	Aspartic Acid	266-279	aminopeptidase	Saccharomyces cerevisiae S288C	72-86
2990528-5	1985	The L isomers of APB, glutamate, and aspartate were more potent as displacers of APB binding than the D isomers.	Aspartic Acid	37-46	arginyl aminopeptidase	Rattus norvegicus	81-84
3906590-8	1985	This feature was exemplified by the substitution of L.Asp by D.Asp, preventing the Trp4-Nle5 cleavage, which gave rise to the most enkephalinase-resistant analog in this series.	Aspartic Acid	63-66	neprilysin	Oryctolagus cuniculus	131-144
3980461-5	1985	Of the smaller peptides studied from this sequence, all peptides containing the Arg-Gly-Asp-Ser sequence, including the tetrapeptide itself, were active in inhibiting Fn binding to platelets (ID50 values approximately 10-20 microM).	Aspartic Acid	88-91	fibronectin 1	Homo sapiens	167-169
3890831-13	1985	Only cathepsin B lacks a polar or negatively charged side chain in the residue analogous to Asp-158 in papain, and this is suggested to account for its total dependence on a protonic dissociation remote from the catalytic site.	Aspartic Acid	92-95	cathepsin B	Bos taurus	5-16
3980461-9	1985	In addition, Arg-Gly-Asp-Ser-containing peptides inhibited the rate and extent of thrombin-induced platelet aggregation.	Aspartic Acid	21-24	coagulation factor II, thrombin	Homo sapiens	82-90
3980461-10	1985	These data suggest that the Arg-Gly-Asp-Ser tetrapeptide contains a recognition specificity involved in the binding of Fn to platelets and that platelets share features of this recognition specificity with fibroblasts.	Aspartic Acid	36-39	fibronectin 1	Homo sapiens	119-121
3156136-6	1985	In gastric H,K-ATPase, the aspartate residue at the active site was determined directly by labeling with [3H]borohydride.	Aspartic Acid	27-36	ATPase	Zea mays	15-21
3887397-1	1985	We have replaced the glutamic acid-165 at the active site of chicken triosephosphate isomerase with an aspartic acid residue using site-directed mutagenesis.	Aspartic Acid	103-116	triosephosphate isomerase 1	Gallus gallus	69-94
3156136-8	1985	This sequence, -Cys-(Ser/Thr)-Asp(P)-Lys-, is similar to that in the calcium ion-transport ATPase of sarcoplasmic reticulum.	Aspartic Acid	30-33	ATPase	Zea mays	91-97
3881753-0	1985	RAD6 gene of Saccharomyces cerevisiae encodes a protein containing a tract of 13 consecutive aspartates.	Aspartic Acid	93-103	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	0-4
3884090-1	1985	Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate.	Aspartic Acid	278-287	pyruvate carboxylase	Homo sapiens	0-20
3856237-3	1985	Construction of chimeric molecules between the transforming and the normal N-ras genes and subsequent biological and sequence analysis of these constructs revealed that the transforming gene was altered by a point mutation changing amino acid 12 of the N-ras protein from glycine to aspartic acid.	Aspartic Acid	283-296	NRAS proto-oncogene, GTPase	Homo sapiens	75-80
3856237-3	1985	Construction of chimeric molecules between the transforming and the normal N-ras genes and subsequent biological and sequence analysis of these constructs revealed that the transforming gene was altered by a point mutation changing amino acid 12 of the N-ras protein from glycine to aspartic acid.	Aspartic Acid	283-296	NRAS proto-oncogene, GTPase	Homo sapiens	253-258
2412755-1	1985	The rod photocurrent was studied by recording the transretinal voltage from the aspartate-treated isolated frog retina before and after perfusion with 2 mM adenosine, which inhibited 60-80% of the light-induced rhodopsin phosphorylation.	Aspartic Acid	80-89	rhodopsin	Homo sapiens	211-220
2865164-2	1985	The amplitude of the depolarizations induced by Glu and by L-aspartate (Asp) in CA3 neurons are markedly augmented by DHKA and HAsp.	Aspartic Acid	59-70	carbonic anhydrase 3	Cavia porcellus	80-83
2865164-2	1985	The amplitude of the depolarizations induced by Glu and by L-aspartate (Asp) in CA3 neurons are markedly augmented by DHKA and HAsp.	Aspartic Acid	72-75	carbonic anhydrase 3	Cavia porcellus	80-83
20492933-7	1985	In the presence of ?-ketoglutarate, the production of (14)CO(2) from [(14)C]Asp may no longer represent AspD activity due to active transamination of Asp, presumably by aspartate aminotransferase, to oxaloacetate.	Aspartic Acid	76-79	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	169-195
6241264-1	1984	The efficiency of translation of the cII gene of bacteriophage lambda is greatly reduced by the cII3059 mutation, a GUU----GAU (Val----Asp) change in the second cII codon.	Aspartic Acid	135-138	lambda CII family protein	Escherichia virus Lambda	37-40
6241264-1	1984	The efficiency of translation of the cII gene of bacteriophage lambda is greatly reduced by the cII3059 mutation, a GUU----GAU (Val----Asp) change in the second cII codon.	Aspartic Acid	135-138	lambda CII family protein	Escherichia virus Lambda	96-99
6527384-2	1984	Oxygen equilibrium studies showed that stripped Hb Wayne Asn and Hb Wayne Asp possessed high oxygen affinity (P 1/2 = 0.60 and 0.23 mmHg at pH 7, respectively), were non-co-operative and have a markedly reduced Bohr effect (-delta log P 1/2/pH (7 to 8) = 0.34 and 0.10, respectively).	Aspartic Acid	74-77	catenin delta 1	Homo sapiens	110-119
6149788-2	1984	In the majority of the lateral septal neurons, iontophoretically applied AVP induced a marked increase in the excitatory responses to glutamate, aspartate, quisqualate and N-methyl-D-aspartate.	Aspartic Acid	145-154	arginine vasopressin	Rattus norvegicus	73-76
6527384-2	1984	Oxygen equilibrium studies showed that stripped Hb Wayne Asn and Hb Wayne Asp possessed high oxygen affinity (P 1/2 = 0.60 and 0.23 mmHg at pH 7, respectively), were non-co-operative and have a markedly reduced Bohr effect (-delta log P 1/2/pH (7 to 8) = 0.34 and 0.10, respectively).	Aspartic Acid	74-77	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	235-243
6391881-7	1984	The overall structural anatomy suggests that the human renin gene evolved by mechanisms that include a duplication of exon segments, particularly those containing the codons for the catalytically important aspartate residues, together with the insertion of other exon and flanking DNA structures.	Aspartic Acid	206-215	renin	Homo sapiens	55-60
6333515-10	1984	The data for R- and M-p10"s shows that they are cleavage products of the gag precursor with the structure p10-Thr-Leu-Asp-Asp-OH.	Aspartic Acid	118-121	melanoma antigen	Mus musculus	73-76
6333515-10	1984	The data for R- and M-p10"s shows that they are cleavage products of the gag precursor with the structure p10-Thr-Leu-Asp-Asp-OH.	Aspartic Acid	122-125	melanoma antigen	Mus musculus	73-76
6517857-7	1984	The 118 kDa component, which contained about 30% of the native mucin protein, consisted mainly of aspartic acid, serine, glutamic acid and glycine (40 mol%), plus threonine, proline, alanine, valine and leucine (35 mol%).	Aspartic Acid	98-111	LOC100508689	Homo sapiens	63-68
6490722-6	1984	Negative controls included another conserved fibronectin peptide from the collagen-binding region containing the sequence Cys-Gln-Asp-Ser-Glu-Thr-Arg-Thr-Phe-Tyr and another peptide.	Aspartic Acid	130-133	fibronectin 1	Homo sapiens	45-56
6520120-6	1984	This is in contrast to the case of bovine pancreatic phospholipase A2 in which Asp-49 (pKa 5.2) is responsible for the metal ion binding (Fleer et al.	Aspartic Acid	79-82	LOC104974671	Bos taurus	53-69
6237366-1	1984	A tetrapeptide sequence, Arg-Gly-Asp-Ser, is the minimal structure recognized by cells in the large, adhesive glycoprotein fibronectin.	Aspartic Acid	33-36	fibronectin 1	Homo sapiens	123-134
6432845-3	1984	We found that the converting activity of Tangier plasma was comparable to that exhibited by control normolipidemic plasma and that in both cases pro-apo A-I was correctly processed at the Gln-Asp bond.	Aspartic Acid	192-195	apolipoprotein A1	Homo sapiens	149-156
16663852-6	1984	On inhibiting glutamine synthetase using MSX, (15)N enrichment of glutamate, alanine, aspartate, and ornithine continued although labeling of glutamine was quite low.	Aspartic Acid	86-95	glutamate-ammonia ligase	Homo sapiens	14-34
6089200-3	1984	This results in substitution of aspartic acid for glycine at this position of the p21 coding sequence.	Aspartic Acid	32-45	H3 histone pseudogene 16	Homo sapiens	82-85
6091743-6	1984	The spin was found to lie in a hydrophobic groove between Phe-3 and Asp-87.	Aspartic Acid	68-71	dihydrolipoamide dehydrogenase	Homo sapiens	58-63
6430904-6	1984	Amino acid analysis of renal CaBP revealed a high content of glutamic and aspartic acids and a low level of methionine, histidine, cysteine, and tyrosine, similar but not identical to chick intestinal CaBP.	Aspartic Acid	74-88	S100 calcium binding protein G	Rattus norvegicus	29-33
6547814-1	1984	The nitro analogs of aspartate and argininosuccinate were synthesized and tested as substrates and inhibitors of argininosuccinate synthetase and argininosuccinate lyase, respectively.	Aspartic Acid	21-30	argininosuccinate lyase	Homo sapiens	146-169
6481966-5	1984	Serum TPA levels correlated well with those of alpha 1-ACT, IAP and ASP in stomach cancer patients and with those of CEA, ASP and sialic acid in colon cancer, but not in esophageal cancer patients.	Aspartic Acid	122-125	plasminogen activator, tissue type	Homo sapiens	6-9
6492941-5	1984	MDP single treatment in vivo (8.26 mumol/kg) produced a three-fold decrease in the high serum aspartate and alanine transaminases induced by CCl4 (5.2 mmol/kg).	Aspartic Acid	94-103	C-C motif chemokine ligand 4	Rattus norvegicus	141-145
6237366-5	1984	Assay of peptides containing the structure Arg-Gly-Asp-X (where X = another amino acid residue) showed that an Arg-Gly-Asp-Val sequence predicted to be present in some, but not all, fibronectin molecules as a result of alternative RNA splicings could potentially create a second cell attachment site in those fibronectin polypeptide chains carrying that sequence.	Aspartic Acid	51-54	fibronectin 1	Homo sapiens	182-193
6237366-5	1984	Assay of peptides containing the structure Arg-Gly-Asp-X (where X = another amino acid residue) showed that an Arg-Gly-Asp-Val sequence predicted to be present in some, but not all, fibronectin molecules as a result of alternative RNA splicings could potentially create a second cell attachment site in those fibronectin polypeptide chains carrying that sequence.	Aspartic Acid	51-54	fibronectin 1	Homo sapiens	309-320
6237366-8	1984	The result presented here show that the arginine, glycine, and aspartic acid residues are absolutely required for the cell recognition, and that the surrounding amino acids may play a role in the expression of cell attachment activity in fibronectin and other proteins having this sequence.	Aspartic Acid	63-76	fibronectin 1	Homo sapiens	238-249
6481966-5	1984	Serum TPA levels correlated well with those of alpha 1-ACT, IAP and ASP in stomach cancer patients and with those of CEA, ASP and sialic acid in colon cancer, but not in esophageal cancer patients.	Aspartic Acid	68-71	plasminogen activator, tissue type	Homo sapiens	6-9
6087340-9	1984	Comparison of the nucleotide sequences of the human cDNA and the genomic clone revealed that the aspartic acid codon at position 71 of preprogastrin is interrupted by the small intron (130 base pairs).	Aspartic Acid	97-110	gastrin	Homo sapiens	135-148
6086335-12	1984	Since this section contains the catalytic residues such as His-36 and Asp-93, we conclude that AK1 can serve as a three-dimensional model of AK2 in mechanistic and drug-designing studies.	Aspartic Acid	70-73	adenylate kinase 1	Bos taurus	95-98
6429132-8	1984	The following unique NH2-terminal amino acid sequence of the purified PSF was obtained: NH2ALA -SER-Ile-Ser-X-X-Asp-Thr-His-Arg-Leu-Thr-Arg-.	Aspartic Acid	111-115	interleukin 3	Mus musculus	70-73
6086335-12	1984	Since this section contains the catalytic residues such as His-36 and Asp-93, we conclude that AK1 can serve as a three-dimensional model of AK2 in mechanistic and drug-designing studies.	Aspartic Acid	70-73	adenylate kinase 2	Bos taurus	141-144
6587385-7	1984	The active site aspartyl residues, corresponding to aspartic acid-32 and -215 of pepsin, are located at residues 33 and 224 in the cathepsin D molecule.	Aspartic Acid	52-65	cathepsin D	Homo sapiens	131-142
6725467-6	1984	(We used mixtures of PTH-Asp-PTH-Glu and PTH-Ile-PTH-Leu.)	Aspartic Acid	25-28	parathyroid hormone	Homo sapiens	21-24
6725467-6	1984	(We used mixtures of PTH-Asp-PTH-Glu and PTH-Ile-PTH-Leu.)	Aspartic Acid	25-28	parathyroid hormone	Homo sapiens	29-32
6725467-6	1984	(We used mixtures of PTH-Asp-PTH-Glu and PTH-Ile-PTH-Leu.)	Aspartic Acid	25-28	parathyroid hormone	Homo sapiens	29-32
6725467-6	1984	(We used mixtures of PTH-Asp-PTH-Glu and PTH-Ile-PTH-Leu.)	Aspartic Acid	25-28	parathyroid hormone	Homo sapiens	29-32
6142755-2	1984	Glutamate or aspartate has tentatively been identified as the neurotransmitter of the projection from CA3 pyramidal cells to strata radiatum and oriens of CA1 and the projection from CA4 pyramidal cells to the inner parts of the molecular layer of area dentata.	Aspartic Acid	13-22	carbonic anhydrase 3	Rattus norvegicus	102-105
6142755-2	1984	Glutamate or aspartate has tentatively been identified as the neurotransmitter of the projection from CA3 pyramidal cells to strata radiatum and oriens of CA1 and the projection from CA4 pyramidal cells to the inner parts of the molecular layer of area dentata.	Aspartic Acid	13-22	carbonic anhydrase 1	Rattus norvegicus	155-158
6142755-2	1984	Glutamate or aspartate has tentatively been identified as the neurotransmitter of the projection from CA3 pyramidal cells to strata radiatum and oriens of CA1 and the projection from CA4 pyramidal cells to the inner parts of the molecular layer of area dentata.	Aspartic Acid	13-22	carbonic anhydrase 4	Rattus norvegicus	183-186
6696878-7	1984	The amino-terminal sequence contained the covalent structure of angiotensin I and was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-X-Glu-Ser-Thr-Cys-Gl u-.	Aspartic Acid	86-89	angiotensinogen	Homo sapiens	64-77
6318832-4	1984	Amino-acid analyses showed that eosinophil peroxidase has a high content of the amino acids arginine, leucine and aspartic acid.	Aspartic Acid	114-127	eosinophil peroxidase	Homo sapiens	32-53
6469695-0	1984	HbA2 Victoria delta 24 (B6) Gly----Asp.	Aspartic Acid	35-38	hemoglobin subunit alpha 2	Homo sapiens	0-4
6395724-7	1984	This sequence is identical with that of residues 491-495 of the sequence for human serum transferrin (MacGillivray et al., 1982) except that in the bovine transferrin, Asp is replaced by Asn, enabling carbohydrate attachment.	Aspartic Acid	168-171	serotransferrin	Bos taurus	89-100
6395724-7	1984	This sequence is identical with that of residues 491-495 of the sequence for human serum transferrin (MacGillivray et al., 1982) except that in the bovine transferrin, Asp is replaced by Asn, enabling carbohydrate attachment.	Aspartic Acid	168-171	serotransferrin	Bos taurus	155-166
6146532-2	1984	DGG and PDA suppressed depolarizations induced in CA3 neurons by short pulses of L-aspartate (Asp), D-homocysteate (DH) or L-glutamate (Glu).	Aspartic Acid	81-92	carbonic anhydrase 3	Cavia porcellus	50-53
6146532-2	1984	DGG and PDA suppressed depolarizations induced in CA3 neurons by short pulses of L-aspartate (Asp), D-homocysteate (DH) or L-glutamate (Glu).	Aspartic Acid	94-97	carbonic anhydrase 3	Cavia porcellus	50-53
6146532-9	1984	These results suggest that DGG and PDA are relatively specific antagonists of excitatory amino acids in the hippocampus, and that Glu (or Asp) is the neurotransmitter released from axons of CA3 neurons.	Aspartic Acid	138-141	carbonic anhydrase 3	Cavia porcellus	190-193
6524712-6	1984	By homology with the sequence of human serum transferrin (MacGillivray et al., 1982) the Lys:Arg and Asp:Gly substitutions probably occur at residues 527 and 446, respectively, from the N-terminus.	Aspartic Acid	101-104	transferrin	Homo sapiens	45-56
6559720-10	1984	administration of 40 mmol/day Mg-asp-HCl, the HPL increase was highly significant.	Aspartic Acid	30-40	galectin 1	Homo sapiens	46-49
6150058-1	1984	The regional distribution and cellular localization of aspartate aminotransferase (AspAT), an glutamate/aspartate metabolizing enzyme, was studied in the hippocampal formation, in dorsal root ganglia, and in superior cervical ganglia during the postnatal development of the rat.	Aspartic Acid	55-64	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	83-88
6150058-5	1984	The increase of AspAT activity parallel to the maturation of glutamatergic/aspartatergic mechanisms suggest that the enzyme studied is involved in glutamate/aspartate neurotransmitter metabolism.	Aspartic Acid	75-84	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	16-21
6362661-9	1983	The typical serine proteinase active-site residues are clearly conserved in C1s, and the specificity-related side chain of the substrate-binding pocket is aspartic acid, as in trypsin, consistent with the proteolytic action of C1s on C4 at an arginine residue.	Aspartic Acid	155-168	complement C1s	Homo sapiens	227-230
6207512-10	1984	One of the ovine brain peptides with GH-releasing activity was partially characterized as His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr- Lys-Arg-Try-Asn-Lys-Glu-Met- Ala-Lys--which is similar to rat GRF and porcine VIP having His at the N-terminus.	Aspartic Acid	98-101	vasoactive intestinal peptide	Rattus norvegicus	209-212
6316328-8	1983	In the first and the third domains, there is a common sequence of nine residues, Glu (or Asp)-Asn-Asn-Thr-Ile-Ser-Ser-Val-Lys, which is highly homologous to one of the proposed Ca2+-binding sequences in bovine brain calmodulin, Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys.	Aspartic Acid	89-92	calmodulin	Bos taurus	216-226
6363674-2	1983	The solubility of insulin may be improved with the addition of small amounts of aspartic acid, glutamic acid, EDTA (ethylenediaminetetraacetic acid), lysine, Tris buffer, or bicarbonate buffer.	Aspartic Acid	80-93	insulin	Homo sapiens	18-25
6643454-8	1983	With [3-13C]pyruvate as substrate, resonances of aspartate C-2 and C-3 and of alanine C-3 were well resolved in addition to those of glutamate C-2, C-3, and C-4.	Aspartic Acid	49-58	complement C2	Rattus norvegicus	59-70
6101060-1	1983	The brain and lung angiotensin converting enzyme (ACE) activities of the mice injected with 10 mg/kg morphine and/or naloxone, 200 mg/kg D- and/or L-aspartic acid were spectrophotometrically determined.	Aspartic Acid	149-162	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	50-53
6101060-2	1983	Morphine, naloxone, D- and L-aspartic acid alone inhibited both brain and lung ACE activities whereas the combinations of morphine with naloxone, D-aspartic acid with L-aspartic acid and morphine with naloxone + L-aspartic acid showed no inhibitory effect on the brain ACE.	Aspartic Acid	27-42	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	79-82
6101060-3	1983	While naloxone or L-aspartic acid partly antagonized the suppression of morphine on the lung ACE their combination completely prevented morphine from inhibiting the lung ACE.	Aspartic Acid	18-33	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	93-96
6101060-3	1983	While naloxone or L-aspartic acid partly antagonized the suppression of morphine on the lung ACE their combination completely prevented morphine from inhibiting the lung ACE.	Aspartic Acid	18-33	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	170-173
6619872-10	1983	The findings are interpreted in the context of the hypothesis that enzymes common to the malate-aspartate shuttle and the tricarboxylic acid cycle are physically complexed in brain, so that inhibition of aspartate aminotransferase, a component of the complex, impedes the flow of carbon through both metabolic pathways.	Aspartic Acid	96-105	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	204-230
6316328-8	1983	In the first and the third domains, there is a common sequence of nine residues, Glu (or Asp)-Asn-Asn-Thr-Ile-Ser-Ser-Val-Lys, which is highly homologous to one of the proposed Ca2+-binding sequences in bovine brain calmodulin, Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys.	Aspartic Acid	228-231	calmodulin	Bos taurus	216-226
6194176-1	1983	From an examination of electroimmunoblots and peptide maps, a mouse monoclonal antibody to human myelin basic protein MBP was shown to react with the amino acid sequence Ala-Ser-Asp-Tyr-Lys-Ser which is located in the C-terminal half of MBP.	Aspartic Acid	178-181	myelin basic protein	Homo sapiens	97-117
6315008-10	1983	On further fragmentation with cathepsin D, a dodecapeptide containing ADP-ribose moiety was isolated whose structure was determined as: Asp-Glu-Glu-Leu-His-Arg-Gly-Tyr-Arg*-Asp-Arg-Tyr.	Aspartic Acid	136-139	cathepsin D	Homo sapiens	30-41
6194176-1	1983	From an examination of electroimmunoblots and peptide maps, a mouse monoclonal antibody to human myelin basic protein MBP was shown to react with the amino acid sequence Ala-Ser-Asp-Tyr-Lys-Ser which is located in the C-terminal half of MBP.	Aspartic Acid	178-181	myelin basic protein	Homo sapiens	118-121
6194176-1	1983	From an examination of electroimmunoblots and peptide maps, a mouse monoclonal antibody to human myelin basic protein MBP was shown to react with the amino acid sequence Ala-Ser-Asp-Tyr-Lys-Ser which is located in the C-terminal half of MBP.	Aspartic Acid	178-181	myelin basic protein	Homo sapiens	237-240
6411730-5	1983	After a 4-h labeling period, we detected completed actin polypeptide chains with either an unblocked Asp or an Ac-Asp NH2 terminus.	Aspartic Acid	101-104	Actin 79B	Drosophila melanogaster	51-56
6411730-8	1983	On the basis of thermolysin digestion studies and experiments using mild acid hydrolysis of a labeled actin NH2-terminal tryptic peptide fragment, we identified this intermediate as having an Ac-Cys-Asp NH2 terminus.	Aspartic Acid	199-202	Actin 79B	Drosophila melanogaster	102-107
6354250-5	1983	The solvent perturbation studies were then extended to the catalytic aspartate residue of yeast hexokinase.	Aspartic Acid	69-78	hexokinase	Saccharomyces cerevisiae S288C	96-106
6411730-9	1983	In a time-dependent fashion, Ac-Cys was removed generating actin with an exposed NH2-terminal Asp which was subsequently acetylated to produce the mature form of actin.	Aspartic Acid	94-97	Actin 79B	Drosophila melanogaster	162-167
6626500-1	1983	Kinetic evidence for involvement of aspartic acid at position P10.	Aspartic Acid	36-49	S100 calcium binding protein A10	Homo sapiens	62-65
6626500-3	1983	The Michaelis-Menten parameters for the hydrolysis of the Arg-Gly bond in F-8 by thrombin were determined to be Kcat = 31 X 10(-11) M [(NIH unit/L) s]-1 and KM = 310 X 10(-6) M. Comparison of these values with those determined previously for native fibrinogen and for a series of similar synthetic peptides, together with information about the amino acid sequences of this portion of the A alpha chain of abnormal fibrinogens, suggests an important role for Asp at position P10.	Aspartic Acid	458-461	coagulation factor VIII	Homo sapiens	74-77
6576785-2	1983	Porcine neuromedin K has been identified by microsequencing as: Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2.	Aspartic Acid	64-67	tachykinin precursor 3	Homo sapiens	8-20
6626500-3	1983	The Michaelis-Menten parameters for the hydrolysis of the Arg-Gly bond in F-8 by thrombin were determined to be Kcat = 31 X 10(-11) M [(NIH unit/L) s]-1 and KM = 310 X 10(-6) M. Comparison of these values with those determined previously for native fibrinogen and for a series of similar synthetic peptides, together with information about the amino acid sequences of this portion of the A alpha chain of abnormal fibrinogens, suggests an important role for Asp at position P10.	Aspartic Acid	458-461	coagulation factor II, thrombin	Homo sapiens	81-89
6308640-7	1983	These results predict that the p21 protein coded for by the spontaneously activated c-has/bas gene will incorporate aspartic acid as its 12th amino acid residue.	Aspartic Acid	116-129	H3 histone pseudogene 16	Homo sapiens	31-34
6308640-8	1983	Computer analysis of the secondary structure of c-has/bas encoded p21 proteins indicates that substitution of the glycine residue located at position 12, not only by aspartic acid or valine but also by any other amino acid, would result in the same structural alteration.	Aspartic Acid	166-179	H3 histone pseudogene 16	Homo sapiens	66-69
6627099-4	1983	LCAT was found to have a relatively high content of glutamic acid, aspartic acid, glycine, and leucine residues and four half-cystines.	Aspartic Acid	67-80	lecithin-cholesterol acyltransferase	Homo sapiens	0-4
6306574-4	1983	MF alpha 1 gene contains 4 copies of the coding sequence for the alpha-factor, which are separated by 24 nucleotides encoding the octapeptide Lys-Arg-Glu-Ala-Glu(or Asp)-Ala-Glu-Ala.	Aspartic Acid	165-168	Mf(Alpha)1p	Saccharomyces cerevisiae S288C	0-10
6862036-2	1983	The purified angiotensinogen has a specific angiotensin I (Ang I) content of 20.7 micrograms Ang I/mg protein and contains only one amino-terminal amino acid, aspartic acid.	Aspartic Acid	159-172	angiotensinogen	Homo sapiens	13-28
6621776-2	1983	In neurons and most glial cells L-CSA uptake is inhibited by acidic amino acids, L-glutamate and L-aspartate and requires sodium ions; however the sodium dependence varies from one cell type to the other.	Aspartic Acid	97-108	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	34-37
6345197-6	1983	Of the functional positions known to be involved in substrate or inhibitor binding, Asp 97, Lys 143 and Arg 217 (Leu in TPA) may contribute to plasminogen activating specificity.	Aspartic Acid	84-87	plasminogen activator, tissue type	Homo sapiens	120-123
6189903-8	1983	The gene coding for P19 had two -Asp-Pro-connections.	Aspartic Acid	33-36	interleukin 23 subunit alpha	Homo sapiens	20-23
6309340-7	1983	Two of four putative isozymes of 17 beta-hydroxysteroid dehydrogenase had serine as the amino terminus while the other two had aspartic acid or asparagine.	Aspartic Acid	127-140	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	33-69
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Aspartic Acid	164-167	Fc gamma receptor and transporter	Homo sapiens	8-19
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Aspartic Acid	164-167	cytochrome b5 type A	Homo sapiens	22-35
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Aspartic Acid	164-167	Fc gamma receptor and transporter	Homo sapiens	45-56
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Aspartic Acid	164-167	cytochrome b5 type A	Homo sapiens	113-126
6863249-6	1983	The contacts present in the beta-chain X cytochrome b5 complex involve hydrogen-bonding between beta-chain lysyl residues 59, 61, 65, and 95, and cytochrome b5 residues 48 (Glu), 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Aspartic Acid	207-210	cytochrome b5 type A	Homo sapiens	41-54
6863249-6	1983	The contacts present in the beta-chain X cytochrome b5 complex involve hydrogen-bonding between beta-chain lysyl residues 59, 61, 65, and 95, and cytochrome b5 residues 48 (Glu), 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Aspartic Acid	207-210	cytochrome b5 type A	Homo sapiens	146-159
6882831-4	1983	The results obtained and literature data suggest that one of the causes of the low catalytic potency of thrombin is a decrease in the hydrophobicity of the environment of Asp-102 located at the active site of the enzyme.	Aspartic Acid	171-174	coagulation factor II, thrombin	Homo sapiens	104-112
6882831-5	1983	Therefore thrombin can cleave only the peptides which hydrophobically shield Asp-102.	Aspartic Acid	77-80	coagulation factor II, thrombin	Homo sapiens	10-18
6853716-7	1983	This amino acid substitution can be explained by a single nucleotide change in the codon for aspartic acid 193 (GAC leads to AAC).	Aspartic Acid	93-106	glycine-N-acyltransferase	Homo sapiens	125-128
6406481-10	1983	The active site aspartyl residue, corresponding to Asp-32 of pepsin, is located at residue 33 in the cathepsin D light chain.	Aspartic Acid	51-54	cathepsin D	Mus musculus	101-112
6101263-1	1983	The protein kinase associated with the purified epidermal growth factor (EGF) receptor from membrane (Mr = 150,000) or vesicle (Mr = 170,000) preparations of A-431 cells was shown to catalyze the phosphorylation of the peptide Leu-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Arg-Arg-Gly at the tyrosine residue.	Aspartic Acid	235-238	epidermal growth factor receptor	Homo sapiens	48-86
6850347-2	1983	Whereas polysynaptic excitation of interneurones was readily and reversibly depressed by 2-APV, 2-APH, beta DAA, gamma DGG and 2,3-PDA, all of which also reduced excitation by NMDA (and L-aspartate) more than that by QUIS (and L-glutamate), no selective antagonism of monosynaptic excitation could be demonstrated.	Aspartic Acid	186-197	acylaminoacyl-peptide hydrolase	Homo sapiens	98-101
6865942-10	1983	Analysis of the DNA sequences of the 5" end of the clones demonstrated that although beta- and gamma-actin genes start with a methionine codon (MET-Asp-Asp-Asp and MET-Glu-Glu-Glu, respectively), the alpha-actin gene starts with a methionine codon followed by a cysteine codon (MET-CYS-Asp-Glu-Asp-Glu).	Aspartic Acid	148-151	POTE ankyrin domain family member F	Homo sapiens	85-106
6865942-10	1983	Analysis of the DNA sequences of the 5" end of the clones demonstrated that although beta- and gamma-actin genes start with a methionine codon (MET-Asp-Asp-Asp and MET-Glu-Glu-Glu, respectively), the alpha-actin gene starts with a methionine codon followed by a cysteine codon (MET-CYS-Asp-Glu-Asp-Glu).	Aspartic Acid	152-155	POTE ankyrin domain family member F	Homo sapiens	85-106
6849812-6	1983	Cystine, tyrosine and aspartic acid significantly lowered body temperature of the CCl4-treated rats, while methionine did not.	Aspartic Acid	22-35	C-C motif chemokine ligand 4	Rattus norvegicus	82-86
6832307-2	1983	The replacement of the N-terminal amino group of aspartic acid by a hydroxyl group gives analogues with lower affinity than [Asn1]- and [Asn1, Leu8]-AII.	Aspartic Acid	49-62	selectin L	Homo sapiens	143-147
6849812-1	1983	Aspartic acid, cystine, methionine and tyrosine were protective against carbon tetrachloride (CCl4)-induced liver necrosis 24 h after its administration, when given 30 min before the hepatotoxin.	Aspartic Acid	0-13	C-C motif chemokine ligand 4	Rattus norvegicus	94-98
6300078-8	1983	Like the aspartate transcarbamylase activity of CAD, the activity was strongly inhibited by high concentrations of aspartate.	Aspartic Acid	9-18	aconitate decarboxylase 1	Homo sapiens	48-51
6833238-2	1983	The acetylmethionine is then cleaved post-translationally, and the new NH2-terminal aspartic acid is acetylated to give the mature form of actin.	Aspartic Acid	84-97	actin	Oryctolagus cuniculus	139-144
6849812-2	1983	Aspartic acid, cystine and tyrosine were also effective when given as late as 6 h after CCl4.	Aspartic Acid	0-13	C-C motif chemokine ligand 4	Rattus norvegicus	88-92
6833238-9	1983	Pulse-chase experiments show that over the course of 1 h, this precursor is transformed first to an actin with a free NH2-terminal aspartic acid and is subsequently converted to mature L-cell actin with an acetylaspartic acid NH2 terminus.	Aspartic Acid	131-144	actin	Oryctolagus cuniculus	100-105
6848515-8	1983	Similar His-Asp pairs have been observed in the serine proteases, thermolysin, and phospholipase A2, and the His-Asp pair may play a similar functional role in all of these enzymes.	Aspartic Acid	12-15	phospholipase A2 group IB	Homo sapiens	83-99
6304819-1	1983	The aspartic acid residue at the penultimate position is known to be essential for the hormonal activity of CCK and gastrin on gastric acid secretion.	Aspartic Acid	4-17	cholecystokinin	Rattus norvegicus	108-111
6304819-1	1983	The aspartic acid residue at the penultimate position is known to be essential for the hormonal activity of CCK and gastrin on gastric acid secretion.	Aspartic Acid	4-17	gastrin	Rattus norvegicus	116-123
6822523-15	1983	Highly purified cysteinesulfinate decarboxylase is also shown to decarboxylate L-aspartate to beta-alanine and, very slowly, glutamate to gamma-aminobutyrate.	Aspartic Acid	79-90	cysteine sulfinic acid decarboxylase	Mus musculus	16-47
6843893-0	1983	Aspartate and glutamate induced reductions in extracellular free calcium and sodium concentration in area CA1 of "in vitro" hippocampal slices of rats.	Aspartic Acid	0-9	carbonic anhydrase 1	Rattus norvegicus	106-109
6843893-6	1983	Thus glutamate- and aspartate-dependent decreases in [Na+] omicron and [Ca2+] omicron appear to be caused by 3 different mechanisms: Na+ movement through amino acid-activated ionophores; Ca2+ movement through selective channels, and Ca2+-dependent Na+ movement.	Aspartic Acid	20-29	carbonic anhydrase 2	Rattus norvegicus	72-75
6843893-6	1983	Thus glutamate- and aspartate-dependent decreases in [Na+] omicron and [Ca2+] omicron appear to be caused by 3 different mechanisms: Na+ movement through amino acid-activated ionophores; Ca2+ movement through selective channels, and Ca2+-dependent Na+ movement.	Aspartic Acid	20-29	carbonic anhydrase 2	Rattus norvegicus	187-190
6843893-6	1983	Thus glutamate- and aspartate-dependent decreases in [Na+] omicron and [Ca2+] omicron appear to be caused by 3 different mechanisms: Na+ movement through amino acid-activated ionophores; Ca2+ movement through selective channels, and Ca2+-dependent Na+ movement.	Aspartic Acid	20-29	carbonic anhydrase 2	Rattus norvegicus	187-190
6848515-8	1983	Similar His-Asp pairs have been observed in the serine proteases, thermolysin, and phospholipase A2, and the His-Asp pair may play a similar functional role in all of these enzymes.	Aspartic Acid	113-116	phospholipase A2 group IB	Homo sapiens	83-99
6629824-0	1983	Hemoglobin Maputo: a new beta-chain variant (alpha 2 beta 2 47 (CD6) Asp replaced by Tyr) in combination with hemoglobin S, identified by high performance liquid chromatography (HPLC).	Aspartic Acid	69-72	CD6 molecule	Homo sapiens	64-67
7174659-2	1982	We conclude that protonation of the mediating ASC system, possibly substrate-assisted, rather than od the free anionic amino acid, converts the system from function for various short chained amino acids to function for aspartate, cysteine sulfinate, and cysteate.	Aspartic Acid	219-228	PYD and CARD domain containing	Rattus norvegicus	46-49
6340098-4	1983	The amino acid sequence of the first 16-residue segment of Rauscher p15 is identical to the sequence of Moloney p15 except for a single amino acid substitution (Gly-->Asp) at position 13.	Aspartic Acid	170-173	cyclin dependent kinase inhibitor 2B	Mus musculus	68-71
7171996-1	1982	Analogues of the putative excitatory transmitters aspartic acid and glutamic acid were tested for antagonism against stimulus-evoked activation of Schaffer collateral-CA 1 pyramidal cell synapses in slices of rat hippocampus.	Aspartic Acid	50-63	carbonic anhydrase 1	Rattus norvegicus	167-171
6924862-4	1982	The kallikrein has an unusual amino acid composition: aspartic acid and glutamic acid comprise 40% of the residues; the total number of basic residues is less than 5%; glycine and proline together make up more than 40% of the residues.	Aspartic Acid	54-67	kallikrein related peptidase 4	Homo sapiens	4-14
7142997-1	1982	The intramuscular administration of a gamma-aminobutyrate-alpha-oxoglutarate aminotransferase (GABA-T) inhibitor, gabaculine, to mice resulted in significant increases in GABA content and decreases in the content of aspartate, glutamate, and glutamine in the nerve endings (synaptosomes).	Aspartic Acid	216-225	4-aminobutyrate aminotransferase	Mus musculus	38-93
7142997-1	1982	The intramuscular administration of a gamma-aminobutyrate-alpha-oxoglutarate aminotransferase (GABA-T) inhibitor, gabaculine, to mice resulted in significant increases in GABA content and decreases in the content of aspartate, glutamate, and glutamine in the nerve endings (synaptosomes).	Aspartic Acid	216-225	4-aminobutyrate aminotransferase	Mus musculus	95-101
6181193-2	1982	With myelin basic protein and one of its major peptic fragments (residues 89-169) as substrates, selective cleavage of Asp(32)-Thr(33), Asp(37)-Ser(38), and Glu(118-Gly(119) bonds was observed, as well as the unusual cleavage of the Gly(127)-Gly(128) bond.	Aspartic Acid	119-122	myelin basic protein	Cavia porcellus	5-25
6983488-2	1982	The contaminant proteinase cleaves the alpha 1-PI component in the alpha 1-PI-chymotrypsinogen A complex close to its N-terminus, between threonine-11 and aspartate-12 and the chymotrypsinogen A part between tyrosine-146 and threonine-147.	Aspartic Acid	155-164	endogenous retrovirus group K member 25	Homo sapiens	16-26
6181193-2	1982	With myelin basic protein and one of its major peptic fragments (residues 89-169) as substrates, selective cleavage of Asp(32)-Thr(33), Asp(37)-Ser(38), and Glu(118-Gly(119) bonds was observed, as well as the unusual cleavage of the Gly(127)-Gly(128) bond.	Aspartic Acid	136-139	myelin basic protein	Cavia porcellus	5-25
6290747-4	1982	From quantitative histochemical investigations of subcortical glomeruli, it can be proven that the aminopeptidase A determined by histochemical means is the angiotensinase A that splits N-terminal aspartate from AI or AII.	Aspartic Acid	197-206	glutamyl aminopeptidase	Rattus norvegicus	99-115
6180646-1	1982	In the C-terminal heptapeptide of cholecystokinin (-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2), replacing the aspartic acid residue by beta-aspartic acid did not alter the ability of the peptide to cause stimulation, desensitization, or residual stimulation of enzyme secretion from dispersed pancreatic acini.	Aspartic Acid	106-119	cholecystokinin	Homo sapiens	34-49
7118418-1	1982	Neutral selenophenol in DMF accomplished the removal of the beta-phenacyl protecting group of aspartic acid in solution, on the peptide Boc-Asp (beta-OPac)- Phe amide and on the resin peptide Boc-Trp(Nin-For)-Met-Asp (beta-OPac)-P (CCK 30-33) without alpha, beta-rearrangement.	Aspartic Acid	94-107	ninein	Homo sapiens	200-203
6889874-7	1982	Because L-Asp antagonizes the acute and chronic effects of morphine, including that on L-asparaginase activity, the hypothesis is proposed that the antagonizing effects of L-Asp observed may be caused at the level of L-asparaginase activity.	Aspartic Acid	8-13	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	87-101
7056352-2	1982	L-Aspartic acid was found to be as effective as imipramine in reducing the effects of forced swimming, presumable by normalizing the decreased level of endogenous L-aspartic acid, due to the inhibition of L-asparaginase activity and/or by stimulating the inhibited enzyme.	Aspartic Acid	0-15	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	205-219
6127053-3	1982	Saturation constants (Ks) of P17 with acetate, arginine, aspartate, glutamate, lactate, succinate, malonate, p-hydroxybenzoate and glucose were all below 1 microM.	Aspartic Acid	57-66	family with sequence similarity 72 member B	Homo sapiens	29-32
6282396-3	1982	Repetitive stimulation and aspartate application caused decreases in [Ca2+]0 (delta Ca), which were largest in the pyramidal cell layer.	Aspartic Acid	27-36	carbonic anhydrase 2	Rattus norvegicus	70-73
7103934-16	1982	The combination of experimental results from the protein studies and the peptide analyses provides strong evidence for the structure of the Ni(II)-binding site of HSA as one that involves the alpha-amino nitrogen atom, two deprotonated peptide nitrogen atoms, the imidazole nitrogen atom and the side-chain carboxy group of the aspartic acid residue.	Aspartic Acid	328-341	albumin	Homo sapiens	163-166
6889874-7	1982	Because L-Asp antagonizes the acute and chronic effects of morphine, including that on L-asparaginase activity, the hypothesis is proposed that the antagonizing effects of L-Asp observed may be caused at the level of L-asparaginase activity.	Aspartic Acid	8-13	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	217-231
6889874-7	1982	Because L-Asp antagonizes the acute and chronic effects of morphine, including that on L-asparaginase activity, the hypothesis is proposed that the antagonizing effects of L-Asp observed may be caused at the level of L-asparaginase activity.	Aspartic Acid	172-177	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	217-231
6329685-1	1982	A peptide Tyr.Arg.Asp.Leu.Lys.Leu corresponding to the carboxy-terminal six amino acids of small-t antigen predicted from the DNA sequence of SV40 was synthesised, coupled to bovine serum albumin and to ovalbumin and used to raise antibody in rabbits.	Aspartic Acid	18-21	albumin	Oryctolagus cuniculus	182-195
6282261-11	1982	The residues forming the "charge-relay" system of the active site of serine proteinases (His-57, Asp-102 and Ser-195 in the chymotrypsinogen numbering) are found in the corresponding regions of C1r b-chain, and the amino acid sequence around these residues has been determined.	Aspartic Acid	97-100	complement C1r	Homo sapiens	194-197
7028733-2	1981	Aspartate is converted to oxalacetate by glutamate-oxalacetate transaminase, and the resulting oxalacetate is converted to malate by the NADH, NAD+ oxidoreductase enzyme malate dehydrogenase.	Aspartic Acid	0-9	oxidoreductase	Escherichia coli	148-162
6129728-5	1982	As GPT and GOT convert alanine and aspartic acid respectively into glutamic acid, a possible mechanism of retardation of kidney stone formation involving enzyme steps via glutamic acid creation in situ is suggested.	Aspartic Acid	35-48	glutamic--pyruvic transaminase	Homo sapiens	3-6
6172156-1	1981	In the C-terminal heptapeptide of cholecystokinin, replacement of the penultimate residue, aspartic acid, by beta-alanine caused a 300-fold decrease in the potency with which the peptide stimulated enzyme secretions, whereas replacement by glutamic acid caused a 1000-fold decrease in potency.	Aspartic Acid	91-104	cholecystokinin	Homo sapiens	34-49
16662144-7	1982	Based on these findings, and on the fact that ornithine, arginine, glutamic acid and aspartic acid are elevated as free amino acids in mutant roots, it is suggested that in the pro(1-1) mutant proline catabolism prevails over proline synthesis.	Aspartic Acid	85-98	profilin-1	Zea mays	177-184
7319057-0	1981	Structural studies of a new hemoglobin: HbJ lens, beta 13(A10) Ala leads to Asp.	Aspartic Acid	76-79	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	58-61
16662116-11	1981	The synthesis of specific members of the aspartate family of amino acids might be expected to differ when the ratio of threonine-sensitive to threonine-resistant homoserine dehydrogenase is altered.	Aspartic Acid	41-50	bifunctional aspartokinase/homoserine dehydrogenase	Zea mays	162-186
7285908-1	1981	meso-Diaminosuccinic acid, a natural antagonist of aspartic acid, is a good substrate for beef kidney D-aspartate oxidase.	Aspartic Acid	51-64	D-aspartate oxidase	Homo sapiens	102-121
6167628-2	1981	The EAE-inducing determinant (synthetic peptide S6) H-Ala-Gln-Gly-His-Arg-Pro-Gln-Asp-Glu-Asn-OH (residues 75 to 84) of the bovine MBP induced clinical and histologic signs of EAE when it was administered at doses of 0.5 micrograms or higher.	Aspartic Acid	82-85	myelin basic protein	Bos taurus	131-134
6800599-0	1981	[Structural analysis of a new slow migration variant of hemoglobin---Hb Duan (alpha 75(EF4)Asp leads to Ala) (author"s transl)].	Aspartic Acid	91-94	GTP binding elongation factor GUF1	Homo sapiens	87-90
7325996-0	1981	Re-activation by glutamate or aspartate of amino-oxyacetate-inhibited aspartate aminotransferase in vitro and in isolated hepatocytes.	Aspartic Acid	30-39	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	70-96
7462241-3	1981	Purified PSP monomer had a Mr = 67,000, was highly acidic on gel electrophoresis, and contained over 35% glutamic and aspartic acid residues.	Aspartic Acid	118-131	phosphoserine phosphatase	Bos taurus	9-12
7213151-1	1981	Aspartic acid concentration in CSF was markedly elevated in a newborn infant with severe, intractable seizures.	Aspartic Acid	0-13	colony stimulating factor 2	Homo sapiens	31-34
7213151-4	1981	Since aspartic acid is a putative excitatory neurotransmitter, a possible causal relationship is suggested between its increased CSF concentration and the occurrence of neonatal convulsions in this family.	Aspartic Acid	6-19	colony stimulating factor 2	Homo sapiens	129-132
7227376-2	1981	Two forms of pig colipase were identified: a predominant A1 form with about 103-105 residues, and a minor slightly degraded A2 form in which the last two C-terminal residues, Asp and Ser, were lacking.	Aspartic Acid	175-178	colipase	Sus scrofa	17-25
7319829-0	1981	Hb Ube-2 (alpha 68[e-17]Asn replaced by Asp): the second instance in Japan.	Aspartic Acid	40-43	ubiquitin like modifier activating enzyme 7	Homo sapiens	3-8
7470887-3	1981	It is concluded that processes of AChE-positive AP neurons terminate within the ASP and may contribute to the AChE activity of ASP capillaries.	Aspartic Acid	80-83	acetylcholinesterase	Rattus norvegicus	34-38
7470887-3	1981	It is concluded that processes of AChE-positive AP neurons terminate within the ASP and may contribute to the AChE activity of ASP capillaries.	Aspartic Acid	80-83	acetylcholinesterase	Rattus norvegicus	110-114
7470887-3	1981	It is concluded that processes of AChE-positive AP neurons terminate within the ASP and may contribute to the AChE activity of ASP capillaries.	Aspartic Acid	127-130	acetylcholinesterase	Rattus norvegicus	34-38
7470887-3	1981	It is concluded that processes of AChE-positive AP neurons terminate within the ASP and may contribute to the AChE activity of ASP capillaries.	Aspartic Acid	127-130	acetylcholinesterase	Rattus norvegicus	110-114
6161125-4	1981	To test this hypothesis, we have synthesized an oligodeoxynucleotide (oligo II) complementary to the region of gastrin mRNA coding for Trp-Met-Asp-Phe and have compared its effectiveness as a hybridization probe and as a primer for the synthesis of gastrin-specific cDNA with another oligonucleotide (oligo I) complementary to the region of gastrin mRNA coding for Trp-Met-Glu-Glu.	Aspartic Acid	143-146	gastrin	Homo sapiens	111-118
6111179-6	1981	Somatostatin potentiates the direct membrane effects of glutamate and aspartate.	Aspartic Acid	70-79	somatostatin	Homo sapiens	0-12
7216819-0	1981	Hemoglobin G Copenhagen beta 47 (CD6) Asp leads to Asn in a Sicilian family.	Aspartic Acid	38-41	CD6 molecule	Homo sapiens	33-36
7227978-3	1981	The data suggest that the malate-aspartate shuttle is triggered by a decrease in the cytosolic oxaloacetate concentration which, due to the cytosolic aspartate aminotransferase equilibrium, leads to an increased efflux of 2-oxoglutarate and aspartate from the mitochondria in exchange for malate and glutamate, respectively.	Aspartic Acid	33-42	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	140-176
7275664-0	1981	Hemoglobin Duan, alpha 75(EF4) Asp replaced by Ala, a new variant found in China.	Aspartic Acid	31-34	GTP binding elongation factor GUF1	Homo sapiens	26-29
7192905-1	1980	Resynthesis of aspartate via glutamate was decreased 6-8-fold in rat brain spinal cord tissues due to distinct inhibition of aspartate aminotransferase in acute alcohol intoxication.	Aspartic Acid	15-24	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	125-151
7275666-0	1981	Hemoglobin Fannin-Lubbock alpha 2 beta 2 119 (GH2) Gly replaced by Asp in Spain.	Aspartic Acid	67-70	growth hormone 2	Homo sapiens	46-49
6273786-0	1981	[Polymorphism of hemoglobins D in Ivory Coast: Hb Korle Bu (beta 73 (E17) Asp leads to Asn), Hb Avicenna (beta 47 (CD6) Asp leads to Ala) and Hb Cocody (beta 21 (B3) Asp leads to Asn) (author"s transl)].	Aspartic Acid	120-123	CD6 molecule	Homo sapiens	115-118
6273786-0	1981	[Polymorphism of hemoglobins D in Ivory Coast: Hb Korle Bu (beta 73 (E17) Asp leads to Asn), Hb Avicenna (beta 47 (CD6) Asp leads to Ala) and Hb Cocody (beta 21 (B3) Asp leads to Asn) (author"s transl)].	Aspartic Acid	120-123	CD6 molecule	Homo sapiens	115-118
6273786-4	1981	The second, Hb Avicenna (beta 47 (CD6) Asp leads to Ala) (pI = 7.225) has not yet been reported in Africa.	Aspartic Acid	39-42	CD6 molecule	Homo sapiens	34-37
6165997-2	1981	beta 2-Microglobulin isolated from histocompatibility antigens of EL4.BU has alanine at this position, whereas that from C14 has aspartic acid.	Aspartic Acid	129-142	beta-2 microglobulin	Mus musculus	0-20
7342337-0	1981	[Haemoglobin Fannin-Lubbock (alpha 2 beta 2 119 (GH2) Gly leads to Asp).	Aspartic Acid	67-70	growth hormone 2	Homo sapiens	49-52
6256167-9	1980	At elevated concentrations, dicyclohexylcarbodiimide still bound specifically to the aspartic acid at residue 61 of the mutant proteolipid as in the wild type, and thereby inhibited the activity of the ATPase complex.	Aspartic Acid	85-98	ATPase	Escherichia coli	202-208
16661476-2	1980	By utilizing the glutamate: oxaloacetate aminotransferase and malate dehydrogenase present in glyoxysomes and mitochondria, reducing equivalents could be transferred between the organelles by a malate-aspartate shuttle.	Aspartic Acid	201-210	malate dehydrogenase, cytoplasmic-like	Ricinus communis	62-82
6776531-7	1980	The NH2-terminal sequence of CNBr II revealed the active site serine of factor D. The typical serine protease active site sequence (Gly-Asp-Ser-Gly-Gly-Pro  was found at residues 12-17.	Aspartic Acid	136-139	coagulation factor II, thrombin	Homo sapiens	94-109
7380843-2	1980	Human gamma-thrombin is a three (noncovalently linked)-domain enzyme which contains the known serine protease catalytic triad, Asp-His-Ser, one on each of the three noncovalent domains (Asp 99 on the A-B3 chain).	Aspartic Acid	127-130	coagulation factor II, thrombin	Homo sapiens	12-20
527670-0	1979	The relationship between morphine, aspartic acid and L-asparaginase in rats.	Aspartic Acid	35-48	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	53-67
6155159-1	1980	In each of two families from Sardinia, Italy, we have found segregation for two alpha-chain hemoglobin variants, which we have identified as G Philadelphia [alpha 68 (E17) Asn leads to Lys] and J Sardinia [alpha 50 (CE8) His leads to Asp], respectively.	Aspartic Acid	234-237	Fc gamma receptor and transporter	Homo sapiens	80-91
6251111-4	1980	Glutamic acid and aspartic acid together accounted for a total of 18 and 19% of the amino acids in purified preparations of NAF I and NAF II, respectively, whereas the basic amino acids lysine, arginine, and histidine represented <2 and 3% of the total residues.	Aspartic Acid	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
6251111-4	1980	Glutamic acid and aspartic acid together accounted for a total of 18 and 19% of the amino acids in purified preparations of NAF I and NAF II, respectively, whereas the basic amino acids lysine, arginine, and histidine represented <2 and 3% of the total residues.	Aspartic Acid	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
7188696-3	1980	In the present study, it is shown that one of these proteases cleaves specifically the peptide bonds on the NH2-terminal side of either aspartic acid or cysteic acid residues in oxidized ribonuclease.	Aspartic Acid	136-149	AV641_RS16750	Pseudomonas fragi	187-199
6105134-4	1980	The numbers of gamma-GT-positive foci induced by B(as)P, 7,12-DMBA, 3-MC and DB (a,h)A were significantly different from all of the parent compounds, anthracene, naphthalene, pyrene and phenanthrene.	Aspartic Acid	50-55	inactive glutathione hydrolase 2	Homo sapiens	15-23
6989823-4	1980	The aspartate saturation curve in the presence of ATP is identical for the two enzymes, but the curve in the presence of CTP and without effectors is shifted toward higher aspartate concentrations for the azatryptophan-substituted enzyme.	Aspartic Acid	172-181	solute carrier family 25 member 1	Homo sapiens	121-124
6997877-10	1980	The active-site residues typical of the serine proteases, histidine-57 and serine-195, are replaced in haptoglobin by lysine and alanine, respectively; however, aspartic acid-102 and the trypsin specificity, residue, aspartic acid-189, do occur in haptoglobin.	Aspartic Acid	217-230	haptoglobin	Homo sapiens	103-114
7354136-3	1980	Lysine and aspartic acid appeared to modify the cholinephosphotransferase reaction in which cytidine 5"-diphosphocholine (CDP-choline) and 1,2-diacylglycerol react to form phosphatidylcholine, the major phospholipid of renal membranes.	Aspartic Acid	11-24	cut-like homeobox 1	Rattus norvegicus	122-125
40605-5	1979	It is suggested that the catalytically essential ionizing group of plasmin having a pK of 8.4 is the alpha-ammonium group of the NH2-terminal Val-561 or the light chain of plasmin, forming an ion pair with a COO- group of an aspartate or glutamate residue.	Aspartic Acid	225-234	plasminogen	Homo sapiens	67-74
505412-2	1979	The fibrinogen is characterized by (1) abnormal side-to-side and end-to-end polymerization, (2) abnormal fibrinopeptide release, (3) a delayed gamma-gamma dimerization of the non cross-linked fibrin, (4) a pH optimum of 7--7.8, and (5) a deviation from normal amino acid composition with regard to lysine, aspartic acid, glutamic acid and serine.	Aspartic Acid	306-319	fibrinogen beta chain	Homo sapiens	4-14
40605-5	1979	It is suggested that the catalytically essential ionizing group of plasmin having a pK of 8.4 is the alpha-ammonium group of the NH2-terminal Val-561 or the light chain of plasmin, forming an ion pair with a COO- group of an aspartate or glutamate residue.	Aspartic Acid	225-234	plasminogen	Homo sapiens	172-179
114208-12	1979	A tryptic peptide, Val-Asp-Lys-Lys, was also isolated from Dob Fd"; this sequence is not found in the variable region of the Dob heavy chain [Steiner, L. A., Garcia Pardo, A., & Margolies, M. N. (1979) Biochemistry (following paper in this issue)] but corresponds to positions 211-214 of the gamma1 constant region.	Aspartic Acid	23-26	major histocompatibility complex, class II, DO beta	Homo sapiens	59-62
114209-14	1979	Positions 10 (aspartic acid), 68 (alanine), and 82 (leucine) in the Dob sequence are also atypical.	Aspartic Acid	14-27	major histocompatibility complex, class II, DO beta	Homo sapiens	68-71
487323-4	1979	Secondarily to these changes, the postulated lack of activation of the lipoamide dehydrogenase (LAD) of the pyruvate dehydrogenase (PDH) complex could result in slow pyruvate oxidation, glucose intolerance, deficient synthesis of acetylcholine, and depletion of glutamic and aspartic acid pools.	Aspartic Acid	275-288	dihydrolipoamide dehydrogenase	Homo sapiens	71-94
315708-0	1979	An alpha 1-antitrypsin variant, Pi B Alhambra (Lys to Asp, Glu to Asp), with rapid anodal electrophoretic mobility.	Aspartic Acid	54-57	serpin family A member 1	Homo sapiens	3-22
315708-0	1979	An alpha 1-antitrypsin variant, Pi B Alhambra (Lys to Asp, Glu to Asp), with rapid anodal electrophoretic mobility.	Aspartic Acid	66-69	serpin family A member 1	Homo sapiens	3-22
315708-8	1979	The amino acid substitution, Gly to Asp, has been found in a common PiM2 variant [1].	Aspartic Acid	36-39	Pim-2 proto-oncogene, serine/threonine kinase	Homo sapiens	68-72
315708-9	1979	The Pi B Alhambra variant presumably originated by two steps of mutation: generation of PiM2 from wild type PiM1 by the substitution Gly to Asp, and subsequent generation of Pi B Alhambra from PiM2 by another substitution, Lys to Asp.	Aspartic Acid	140-143	Pim-2 proto-oncogene, serine/threonine kinase	Homo sapiens	88-92
487323-4	1979	Secondarily to these changes, the postulated lack of activation of the lipoamide dehydrogenase (LAD) of the pyruvate dehydrogenase (PDH) complex could result in slow pyruvate oxidation, glucose intolerance, deficient synthesis of acetylcholine, and depletion of glutamic and aspartic acid pools.	Aspartic Acid	275-288	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	108-130
487323-4	1979	Secondarily to these changes, the postulated lack of activation of the lipoamide dehydrogenase (LAD) of the pyruvate dehydrogenase (PDH) complex could result in slow pyruvate oxidation, glucose intolerance, deficient synthesis of acetylcholine, and depletion of glutamic and aspartic acid pools.	Aspartic Acid	275-288	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	132-135
311826-2	1979	Aspartate-isolated photoresponses of the frog"s rods to weak and strong flashes have been recorded during dark-adaptation after bleaching a fraction of rhodopsin (generally 4--30%).	Aspartic Acid	0-9	rhodopsin	Homo sapiens	152-161
571739-2	1979	Phosphoenolpyruvate carboxylase (orthophosphate:oxaloacetate carboxylase (phosphorylating), EC 4.1.1.31) from plant cells of soybean nodules was studied to assess its role in providing carbon skeletons for aspartate and asparagine synthesis.	Aspartic Acid	206-215	phosphoenolpyruvate carboxylase, housekeeping isozyme	Glycine max	0-31
475759-0	1979	The isolation, characterization and partial sequence of a peptide rich in glutamic acid and aspartic acid (HGA-2 peptide) from calf thymus non-histone chromosomal protein HMG 2.	Aspartic Acid	92-105	high mobility group protein B2	Bos taurus	171-176
427203-0	1979	Haemoglobin Avicenna (beta 47 (CD6) Asp replaced by Ala).	Aspartic Acid	36-39	CD6 molecule	Homo sapiens	31-34
30754-6	1978	Measurement of amino acid uptake show that the mutants with high glutamine synthetase levels have increased rates for glutamine, arginine, aspartate, and lysine, but a decreased rate for proline.	Aspartic Acid	139-148	type I glutamate--ammonia ligase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	65-85
261660-6	1979	Cysteinesulphinate transaminase A has a Km of 9.8 mM for cysteinesulphinic acid and 0.25 mM for aspartic acid, whereas the B enzyme has a Km of 6.5 mM for cysteinesulphinic acid and 1.4 mM for aspartic acid.	Aspartic Acid	96-109	glutamic-oxaloacetic transaminase 2	Homo sapiens	19-33
261660-6	1979	Cysteinesulphinate transaminase A has a Km of 9.8 mM for cysteinesulphinic acid and 0.25 mM for aspartic acid, whereas the B enzyme has a Km of 6.5 mM for cysteinesulphinic acid and 1.4 mM for aspartic acid.	Aspartic Acid	193-206	glutamic-oxaloacetic transaminase 2	Homo sapiens	19-33
478976-0	1979	Hemoglobin Sunshine Seth - alpha 2 (94 (G1) Asp replaced by His) beta 2.	Aspartic Acid	44-47	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	65-71
760280-2	1979	Salts of aspartic acid were administered in tap water after irradiation.	Aspartic Acid	9-22	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	44-47
439027-7	1979	Computer analysis has indicated that ibotenate and cis-1-amino-1,3-dicarboxy-cyclopentane have relatively fixed and similar C alpha-N, Comega-N and C alpha-Comega interatomic distances which can also be achieved by glutamate in certain conformations of the molecule, but not by aspartate.	Aspartic Acid	278-287	suppressor of cytokine signaling 1	Homo sapiens	51-56
214557-3	1978	The residue in position 15 of secretin, aspartic acid, was replaced by lysine, which occupies that position in the vasoactive intestinal polypeptide (VIP), a member of the secretin family.	Aspartic Acid	40-53	vasoactive intestinal peptide	Rattus norvegicus	115-148
214557-3	1978	The residue in position 15 of secretin, aspartic acid, was replaced by lysine, which occupies that position in the vasoactive intestinal polypeptide (VIP), a member of the secretin family.	Aspartic Acid	40-53	vasoactive intestinal peptide	Rattus norvegicus	150-153
667168-2	1978	The sequence of chicken histone H2A differs from the calf homologous histone by the deletion of one residue of histidine at position 123 or 124 and three conservative substitutions: a residue of serine replaces a residue of threonine at position 16, a residue of aspartic acid replaces a residue of glutamic acid at position 121 and a residue of alanine replaces a residue of glycine at position 128.	Aspartic Acid	263-276	H2A histone family, member J	Gallus gallus	24-35
417147-3	1978	The requirement for aspartate was due to a low activity of pyruvate carboxylase; the site of the mutation (pyc) was linked (16% cotransducible using phage PBSI) to the pyrD locus, and the order of markers deduced was: pyrD-cysC-pyc.	Aspartic Acid	20-29	pyruvate carboxylase	Bacillus subtilis subsp. subtilis str. 168	59-79
629933-5	1978	The residues forming the "charge-relay" system of the active site of chymotrypsin (His-57, Asp-102, and Ser-195) are found in corresponding regions in GSP, whereas an alanyl residue at position 176 of GSP corresponds to a residue which participates in the primary substrate binding site in serine proteases (Asp-177 in trypsin; Ser-189 in chymotrypsin).	Aspartic Acid	91-94	mast cell protease 2	Rattus norvegicus	151-154
629933-5	1978	The residues forming the "charge-relay" system of the active site of chymotrypsin (His-57, Asp-102, and Ser-195) are found in corresponding regions in GSP, whereas an alanyl residue at position 176 of GSP corresponds to a residue which participates in the primary substrate binding site in serine proteases (Asp-177 in trypsin; Ser-189 in chymotrypsin).	Aspartic Acid	308-311	mast cell protease 2	Rattus norvegicus	151-154
711162-3	1978	The identity of the acid-transformed derivative was determined as [A21-desamido]insulin by the action of carboxypeptidase A, using conditions under which a C-terminal aspartic acid residue would not be removed.	Aspartic Acid	167-180	insulin	Bos taurus	80-87
711315-8	1978	Matings between multiply marked strains demonstrated that the position of tox-1 with respect to other genetic loci in linkage group I is as follows: met-2--trp-1--asp-1--nal-1--his-1--tox-1.	Aspartic Acid	163-166	thymocyte selection associated high mobility group box	Homo sapiens	74-79
645868-1	1978	[14C]angiotensin II ([14C]AII) was microinjected alone or with excess L-isoleucine (IIe) or L-aspartic acid (Asp) into renal tubules of anesthetized rats.	Aspartic Acid	92-107	angiotensinogen	Rattus norvegicus	5-19
645868-1	1978	[14C]angiotensin II ([14C]AII) was microinjected alone or with excess L-isoleucine (IIe) or L-aspartic acid (Asp) into renal tubules of anesthetized rats.	Aspartic Acid	109-112	angiotensinogen	Rattus norvegicus	5-19
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Aspartic Acid	265-268	vitronectin	Homo sapiens	4-13
24309-4	1977	Enzyme activities are based on the formation of oxaloacetate (GOT) or pyruvate (GPT) from aspartic acid and alanine respectively with oxoglutarate.	Aspartic Acid	90-103	alanine aminotransferase 1	Sus scrofa	80-83
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Aspartic Acid	265-268	vitronectin	Homo sapiens	166-175
24425216-14	1977	Studies with 3-mercaptopicolinic acid, a specific inhibitor of PEP-CK, have indicated that most (about 70%) of the OAA formed from aspartate is decarboxylated through the chloroplastic PEP-CK and the remaining (about 30%) OAA through the mitochondrial NAD-ME.	Aspartic Acid	131-140	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	63-69
921425-3	1977	Since carboxyhemoglobin and cyanmethemoglobin Hasharon were as stable in the heat stability test as identically liganded Hb A, we conclude that the substitution of the hydrophilic aspartate residue by histidine on the surface of the molecule at alpha47 has led by a still unknown mechanism to an interaction of hemoglobin with the drug that labilized the heme-globin bond.	Aspartic Acid	180-189	sodium voltage-gated channel alpha subunit 2	Homo sapiens	121-125
889877-3	1977	Evidence is presented that the glucagon sequence -Thr-Ser-Asp-Tyr-Ser-Lys-Tyr- is found in the gut GLI-1 as well.	Aspartic Acid	58-61	GLI family zinc finger 1	Homo sapiens	99-104
895448-0	1977	[Effect of magnesium aspartate on the activity of cholinesterase].	Aspartic Acid	11-30	butyrylcholinesterase	Homo sapiens	50-65
17398-6	1977	When the amino acid content of the enzymes was analysed, carboxypeptidase B2 had four more glycine and three more aspartic acid residues than had form B1.	Aspartic Acid	114-127	carboxypeptidase B2	Homo sapiens	57-76
832807-1	1977	Two derivatives of the C-terminal tripeptide of gastrin devoid of -NH2 from the phenylalanyl residue and of -COOH from the aspartic acid, MBOC-Met.Asn.Phe-OH (I) and MBOC-Met.Asp-OBenz.Phe-OMe (II), stimulated gastric acid secretion in the dog when infused intravenously at doses of 100 to 400 mug/kg-hr.	Aspartic Acid	123-136	gastrin	Canis lupus familiaris	48-55
13825-5	1977	The results obtained indicate that substitutions in aspartic acid 1, proline 7, and phenylalanine 8 of angiotensin II entail changes in the backbone conformation.	Aspartic Acid	52-65	angiotensinogen	Homo sapiens	103-117
604315-0	1977	Hemoglobin Gavello - alpha 2 beta 2 47 (CD6) Asp replaced by Gly.	Aspartic Acid	45-48	CD6 molecule	Homo sapiens	40-43
560212-0	1977	Stereospecific ring opening of conduritol-B-epoxide by an active site asparatate residue of sucrase-isomaltase.	Aspartic Acid	70-80	sucrase-isomaltase	Homo sapiens	92-110
560212-1	1977	Conduritol-B-epoxide inactivates sucrase-isomaltase (sucrose alpha-glucohydrolase, EC 3.2.1.48-dextrin 6-alpha-glucohydrolase, EC 3.2.1.10) irreversibly with incorporation of 1 mol inhibitor/mol subunit, the affinity label being bound in both subunits to a beta-carboxyl group of an aspartic acid (Quaroni, A. and Semnza; G. (1976) J. Biol.	Aspartic Acid	283-296	sucrase-isomaltase	Homo sapiens	33-51
871045-3	1977	Mathematical computer-assisted programs developed to aid in determining clusters of amino acid variables suggested that excretion of glycine, leucine, proline, and glutamic acid in men and concentrations of valine, serine, aspartic acid, phenylalanine, and lysine in women vary according to the invasiveness of the disease.	Aspartic Acid	223-236	activation induced cytidine deaminase	Homo sapiens	53-56
871069-6	1977	In rhizomelic form of ASp, active Paget"s disease, osteomalacia and in some forms of osteoporosis there was congruence between increased activity of B-ALP and the positive 85Sr test over the clinically involved area of the locomotor system.	Aspartic Acid	22-25	ATHS	Homo sapiens	151-154
32019-3	1977	Thus, in stratum radiatum and oriens of CA1, 85% of glutamate and asparate uptake and 40% of glutamate and aspartate content are lost after lesions of ipsilateral plus commissural fibres from CA3/CA4.	Aspartic Acid	107-116	carbonic anhydrase 1	Rattus norvegicus	40-43
892988-3	1977	A description is given of the synthesis by fragment condensation of the peptides Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp and Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp respectively corresponding to the 5-17 and 1-17 amino acid sequences of rat pancreatic ribonuclease.	Aspartic Acid	97-100	ribonuclease A family member 1, pancreatic	Rattus norvegicus	281-304
24425216-9	1977	In vivo both aspartate and malate are considered as transport metobolites from mesophyll to bundle-sheath cells in PEP-CK species.	Aspartic Acid	13-22	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	115-121
24425216-14	1977	Studies with 3-mercaptopicolinic acid, a specific inhibitor of PEP-CK, have indicated that most (about 70%) of the OAA formed from aspartate is decarboxylated through the chloroplastic PEP-CK and the remaining (about 30%) OAA through the mitochondrial NAD-ME.	Aspartic Acid	131-140	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	185-191
24425216-14	1977	Studies with 3-mercaptopicolinic acid, a specific inhibitor of PEP-CK, have indicated that most (about 70%) of the OAA formed from aspartate is decarboxylated through the chloroplastic PEP-CK and the remaining (about 30%) OAA through the mitochondrial NAD-ME.	Aspartic Acid	131-140	malic enzyme 2	Homo sapiens	252-258
182215-6	1976	The quaternary adducts formed by H2O2 oxidation in the presence of aspartokinase, Co(II), ATP, aspartate, and threonine comprised a mixture of both ezyme-Co(III)-ATP-aspartate and enzyme-Co(III)-ATP-threonine adducts.	Aspartic Acid	166-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
972444-7	1976	A relationship was found between plasma transferrin concentration and ASP.	Aspartic Acid	70-73	transferrin	Homo sapiens	40-51
1086346-7	1976	The KRG decrease has the rhodopsin action spectrum, is maximal in the photoreceptor layer, persists after aspartate treatment, and has an increment threshold curve which saturates at moderate background intensities.	Aspartic Acid	106-115	rhodopsin	Homo sapiens	25-34
1269091-4	1976	Of the components of the malate-aspartate cycle, flux through the malate-alpha-ketoglutarate exchange was increased prior to that through the glutamate-aspartate exchange and intramitochondrial aspartate aminotransferase.	Aspartic Acid	32-41	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	194-220
938666-3	1976	The present study has investigated the possibility that the glutamic and aspartic acid residues of elastin are amidated.	Aspartic Acid	73-86	elastin	Homo sapiens	99-106
938666-7	1976	This analysis indicated that autoclaved ligament elastin contains approximately 18 glutamine, 3 asparagine, 4 glutamic acid and 5 aspartic acid residues per 1000 residues, in good agreement with the analysis of total acid-labile ammonia.	Aspartic Acid	130-143	elastin	Homo sapiens	49-56
1252449-1	1976	All the reactive amino groups in soybean trypsin inhibitor (Kunitz) were protected by guanidination of 9 out of 10 lysyl residues with O-methylisourea and by carbamoylation of the NH2 terminal Asp with potassium cyanate.	Aspartic Acid	193-196	kunitz trypsin protease inhibitor	Glycine max	41-67
1260137-0	1976	Hemoglobin pyrgos alpha2 beta2 83 (EF7) Gly leads to Asp: a new hemoglobin variant in double heterozygosity with hemoglobin S. An electrophoretically fast-moving hemoglobin variant was found to be present together with hemoglobin S, in the hemolysate of the rythrocytes of at 3-yr-old Greek boy.	Aspartic Acid	53-56	FAM3 metabolism regulating signaling molecule D	Homo sapiens	35-38
1260137-6	1976	Structural analysis of the variant hemoglobin revealed substitution of an aspartic acid for the glycine residue at the beta83 (EF7) position.	Aspartic Acid	74-87	FAM3 metabolism regulating signaling molecule D	Homo sapiens	127-130
1025895-0	1976	[Regulation of L-asparaginase biosynthesis in mutants of Bacillus mesentericus 43A, poorly growing in the presence of aspartic acid].	Aspartic Acid	118-131	AKO65_RS01520	Bacillus pumilus	15-29
1254727-12	1976	Paired studies with Asp-1, Ile-5 AII also demonstrated a consistent reduction in LpA.	Aspartic Acid	20-23	angiotensinogen	Rattus norvegicus	33-36
1194371-2	1975	The relationship between intracellular and extracellular aspartate pools and myosin synthesis.	Aspartic Acid	57-66	myosin, heavy chain 15	Gallus gallus	77-83
823055-5	1975	T-hCG-C was poorer in aspartic acid and glycine, and richer in serine, threonine and tyrosin to which carbohydrates bind than hCFSH from normal pregnancy.	Aspartic Acid	22-35	hypertrichosis 2 (generalised, congenital)	Homo sapiens	2-5
1194371-5	1975	Specific activities of aspartic acid in plasma and cellular pools corrected for extracellular space contributions have been correlated with aspartate incorporation onto myosin.	Aspartic Acid	23-36	myosin, heavy chain 15	Gallus gallus	169-175
1194371-5	1975	Specific activities of aspartic acid in plasma and cellular pools corrected for extracellular space contributions have been correlated with aspartate incorporation onto myosin.	Aspartic Acid	140-149	myosin, heavy chain 15	Gallus gallus	169-175
812233-13	1975	griseus, alpha-amylase from Asp.	Aspartic Acid	28-31	LOW QUALITY PROTEIN: pancreatic alpha-amylase	Sus scrofa	9-22
1057162-3	1975	The exception is the replacement of Ile-255 at the bottom of the substrate binding pocket of carboxypeptidase A, by aspartic acid in carboxypeptidase B.	Aspartic Acid	116-129	carboxypeptidase B1	Bos taurus	133-151
1148225-1	1975	The complete amino acid sequence of 87 residues of cyanogen bromide fragment CB1 (Asp), the N-terminal fragment of human plasma albumine molecule, has been established.	Aspartic Acid	82-85	cannabinoid receptor 1	Homo sapiens	77-80
1148225-3	1975	Overlaps were obtained by tryptic and chymotryptic cleavage of the maleylated S-sulfo derivative of fragment CB1(Asp).	Aspartic Acid	113-116	cannabinoid receptor 1	Homo sapiens	109-112
1164510-1	1975	Hemoglobin Fort Gordon, alpha2beta2145 Tyr replaced by Asp (HC2), has been observed in a 20-year-old black male with compensatory erythrocytosis.	Aspartic Acid	55-58	CYCS pseudogene 38	Homo sapiens	60-63
24419545-5	1974	As well as lysine, the content of other amino acids, such as aspartic acid, arginine, glycine, threonine, valine and histidine are also, in general, increased by the presence of the o 2 gene in recessive homozygous condition.The results obtained have shown that a number of correlation coefficients between the protein quality traits and yield components related to kernel characteristics are negative and significant, especially in the presence of the o 2 gene in recessive homozygous condition.	Aspartic Acid	61-74	regulatory protein opaque-2	Zea mays	182-185
1138883-2	1975	The substitution is at residue 47 (CD5) of the alpha chain in which aspartic acid has been substituted by asparagine.	Aspartic Acid	68-81	CD5 molecule	Homo sapiens	35-38
48419-8	1975	The following amino acids were found in CEA: lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, emthionine, isoleucine, leucine, tyrosine, phenylalanine, and cysteine.	Aspartic Acid	74-87	CEA cell adhesion molecule 3	Homo sapiens	40-43
1098653-11	1975	The utility of the method is demonstrated by repeating the determination of the substitution in haemoglobin Hopkins-2, a known alpha-chain core variant in which histidine-alpha112 (G19) is replaced by an aspartic acid residue.	Aspartic Acid	204-217	Fc gamma receptor and transporter	Homo sapiens	127-138
4281477-0	1974	[Hemoglobin Setif (alpha 94(G1) Asp yields Tyr).	Aspartic Acid	32-35	proline rich protein BstNI subfamily 3	Homo sapiens	19-30
4375805-0	1974	[A case of hemoglobin Korle Bu (beta 73(E17) Asp yields Asn) in the Ivory Coast.	Aspartic Acid	45-48	small nucleolar RNA, H/ACA box 73A	Homo sapiens	32-43
18961000-4	1971	The order in terms of secondary ligands has been found to be ASPA > Gly > Aln and Gly > Aln > ASPA with iminodiacetic and nitrilotriacetic acid as primary ligands respectively (ASPA = aspartic acid, Gly = glycine, Aln = dl-alanine).	Aspartic Acid	196-209	aspartoacylase	Homo sapiens	106-110
19999712-3	1973	Lupin component II: Ala26, Arg1, (Asp + Asn)18, (Glu + Gln)20, Gly9, His5, Ile10, Leu16, Lys18, Met1, Phe8, Pro6, Ser12, Thr10, Trp3, Tyr2 and Val18.	Aspartic Acid	34-37	5'-nucleotidase, cytosolic IIIA	Homo sapiens	0-5
4352715-12	1972	Glutamic acid and aspartic acid were the free N-terminal amino acids of human subcomponent C1q whereas only serine was found in rabbit subcomponent C1q.	Aspartic Acid	18-31	complement C1q A chain	Homo sapiens	91-94
4333193-0	1972	Physicochemical studies of the relation between structure and function in hemoglobin Hiroshima (HC3 , histidine leads to aspartate).	Aspartic Acid	121-130	CYCS pseudogene 24	Homo sapiens	96-99
5144745-8	1971	Similar results were obtained for Amaranthus leaves except that the C-4 of aspartate rather than malate was apparently the primary source of CO(2).	Aspartic Acid	75-84	complement C4A (Rodgers blood group)	Homo sapiens	68-71
18961000-4	1971	The order in terms of secondary ligands has been found to be ASPA > Gly > Aln and Gly > Aln > ASPA with iminodiacetic and nitrilotriacetic acid as primary ligands respectively (ASPA = aspartic acid, Gly = glycine, Aln = dl-alanine).	Aspartic Acid	196-209	aspartoacylase	Homo sapiens	106-110
5097573-9	1971	In elastin from plaque intima, the following polar amino acids were increased significantly: aspartic acid, threonine, serine, glutamic acid, lysine, histidine, and arginine; whereas, cross-linking amino acids: desmosine, isodesmosine, and lysinonorleucine were decreased significantly.	Aspartic Acid	93-106	elastin	Homo sapiens	3-10
4399928-1	1971	The hydrocortisone-mediated induction of glutamine synthetase in the neural retina of chicken embryo in vitro is correlated with enhanced incorporation into protein of [(14)C]aspartic acid, an amino acid abundant in this enzyme.	Aspartic Acid	175-188	glutamate-ammonia ligase	Gallus gallus	41-61
5460202-0	1970	Two haemoglobins Q, alpha-74 (EF3) and alpha-75 (EF4) aspartic acid to histidine.	Aspartic Acid	54-67	GTP binding elongation factor GUF1	Homo sapiens	49-52
6023254-1	1967	Human transferrin D(1) obtained from an Australian aborigine was found to have the same substitution of glycine for aspartic acid in peptide 1C previously shown in transferrin D(1) from an American Negro.	Aspartic Acid	116-129	transferrin	Homo sapiens	6-17
4386407-3	1968	Foetal rat liver slices incorporate the C-3 of aspartate and C-2 of glutamate into fatty acids at rates equal to those observed with adult rat liver slices.	Aspartic Acid	47-56	complement C3	Rattus norvegicus	40-43
24435664-8	1970	However, in a distinctly different background, su 1 significantly increased alpha aminobutyric acid but significantly decreased aspartic acid and glutamic acid.	Aspartic Acid	128-141	isoamylase 1, chloroplastic	Zea mays	47-51
4302176-9	1968	Esterification of collagen, which neutralizes 80-90% of the free carboxyl groups, reduced coagulant activity by over 90% and it is suggested that the free carboxyl groups of glutamic and aspartic acids provide the negatively charged sites critical for Hageman factor activation.	Aspartic Acid	187-201	coagulation factor XII	Homo sapiens	252-266
5735915-0	1968	[The effect of insulin on the intensity of conversion of glycine-2C-14 to serine, aspartate and glutamate in the brain and liver].	Aspartic Acid	82-91	insulin	Homo sapiens	15-22
6023254-1	1967	Human transferrin D(1) obtained from an Australian aborigine was found to have the same substitution of glycine for aspartic acid in peptide 1C previously shown in transferrin D(1) from an American Negro.	Aspartic Acid	116-129	transferrin	Homo sapiens	164-175
5971784-1	1966	Reinvestigation of the amino acid sequence of bovine chymotrypsinogen A suggests that the amino acid sequence at the N-terminus of the B-chain (residues 16-19) is -Ile-Val-Asn-Gly- rather than -Ile-Val-Gly-Asp- and that Ser-215 should be deleted.	Aspartic Acid	206-209	chymotrypsinogen A	Bos taurus	53-71
16591538-0	1967	A single amino Acid substitution (asparagine to aspartic Acid) between normal (b+) and the common negro variant (a+) of human glucose-6-phosphate dehydrogenase.	Aspartic Acid	48-61	glucose-6-phosphate dehydrogenase	Homo sapiens	126-159
17809412-2	1965	There is a difference in one peptide, and amino acid analyses indicate that an aspartic acid residue in transferrin C is replaced probably by a glycine residue in transferrin D(1).	Aspartic Acid	79-92	transferrin	Homo sapiens	104-115
16749136-7	1965	Such results, indicative of the presence of unbound serine residues, allow, in submaxillary mucin, for a close correlation between the remaining serine, threonine, glutamic acid and aspartic acid and the available sialyl-(2-->6)-N-acetylgalactosamine prosthetic groups.	Aspartic Acid	182-195	LOC100508689	Homo sapiens	92-97
4958545-1	1966	Demonstration of a binding of aspartic acid and glucosamine and an O-threonyl-glycoside binding in human lactotransferrin].	Aspartic Acid	30-43	lactotransferrin	Homo sapiens	105-121
5902571-8	1966	Reasons are given for considering the prompt inhibition of protein synthesis in the asparagine-dependent -OG cells a direct result of asparagine-deprivation induced in vivo by the injected guinea pig serum, the L-asparaginase of which presumably converted the available L-asparagine of the host to L-aspartic acid that was not taken up by the -OG cells.	Aspartic Acid	298-313	asparaginase like 1	Mus musculus	211-225
5902571-13	1966	The findings are considered in relation to the probability, disclosed in part by previous studies, that heated guinea pig serum brings about its effects upon Lymphoma 6C3HED-OG cells in vivo by providing active L-asparaginase in large amounts, which presumably converts the available (extracellular) asparagine of the host to aspartic acid, the latter not being taken up by the lymphoma cells in vivo or in vitro.	Aspartic Acid	326-339	asparaginase like 1	Mus musculus	211-225
4954095-1	1965	Demonstration of a bond of aspartic acid with the mucopolyoside group in human transferrin].	Aspartic Acid	27-40	transferrin	Homo sapiens	79-90
14340066-10	1965	The proposed amino acid sequence is: Asp-Asp-Ser-Ile/Leu-Asp-Ser-Leu/Ile-ArgThis peptide is released by lamprey thrombin but not by bovine thrombin.	Aspartic Acid	37-40	coagulation factor II, thrombin	Bos taurus	112-120
14338684-0	1965	[EFFECTS OF ASPARTATES ON THE BRAIN ACTIVITY OF THE CAT].	Aspartic Acid	12-22	catalase	Homo sapiens	52-55
14340066-10	1965	The proposed amino acid sequence is: Asp-Asp-Ser-Ile/Leu-Asp-Ser-Leu/Ile-ArgThis peptide is released by lamprey thrombin but not by bovine thrombin.	Aspartic Acid	41-44	coagulation factor II, thrombin	Bos taurus	112-120
14340066-10	1965	The proposed amino acid sequence is: Asp-Asp-Ser-Ile/Leu-Asp-Ser-Leu/Ile-ArgThis peptide is released by lamprey thrombin but not by bovine thrombin.	Aspartic Acid	41-44	coagulation factor II, thrombin	Bos taurus	112-120
33741381-8	2021	Asp-X3-CH3 did not cause significant loss of COX-1 expression in gastric mucosal cells, whereas Asp-X3 and Aspirin both caused significant loss of COX-1 expression as demonstrated by western blot, consistent with their effects on the content of PGE2 in these cells as determined by ELISA assay.	Aspartic Acid	96-99	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	147-152
13926303-0	1961	The effect of growth hormone on the incorporation of N15 from ammonium citrate, glycine, L-aspartic acid, L-alanine and L-glutamic acid into amino acids of liver protein.	Aspartic Acid	89-104	growth hormone 1	Homo sapiens	14-28
33882424-2	2021	The prosthetic heme group is covalently attached to LPO through two ester linkages involving conserved glutamate and aspartate residues.	Aspartic Acid	117-126	lactoperoxidase	Homo sapiens	52-55
16654832-2	1956	Effect of 2,4-D on the Metabolism of Aspartic Acid and Glutamic Acid in the Bean Plant.	Aspartic Acid	37-50	brain expressed associated with NEDD4 1	Homo sapiens	76-80
33741381-9	2021	However, both Asp-X3-CH3 and Asp-X3 exerted a similar effect on the level of COX-2 in gastric cancer cells, causing as much as 90% and 95% reduction in COX-2 expression, respectively.	Aspartic Acid	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
33741381-9	2021	However, both Asp-X3-CH3 and Asp-X3 exerted a similar effect on the level of COX-2 in gastric cancer cells, causing as much as 90% and 95% reduction in COX-2 expression, respectively.	Aspartic Acid	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
34037204-4	2021	The recognition of residues other than Asp in the P1 position of the substrate by caspase-3/-7 has been reported, promoting interest in the effects of phosphorylation of amino acids in the direct vicinity of the scissile bond.	Aspartic Acid	39-42	caspase 3	Homo sapiens	82-94
33404730-10	2021	The analysis of systematic mutations in the insertion region of Scc3 revealed two conserved aspartic acid residues that are essential for the activity.	Aspartic Acid	92-105	Irr1p	Saccharomyces cerevisiae S288C	64-68
33960368-8	2021	Mapping these pS/pT sites on the hTDO surface revealed their propinquity to acidic Asp/Glu (D/E) residues engendering negatively charged DEpSpT clusters vicinal to the ubiquitination K sites over the entire protein surface.	Aspartic Acid	83-86	tryptophan 2,3-dioxygenase	Homo sapiens	33-37
34026780-6	2021	Recently, an amino acid aspartate (D) to glycine (G) (D614G) mutation due to an adenine to guanine nucleotide change at position 23,403 at the 614th amino-acid position of the spike protein in the original reference genotype has been identified.	Aspartic Acid	24-33	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	176-181
34041566-9	2021	The non-synonymous SNP rs2274907 (c.326T > A) located in exon 4 of the ITLN1 gene results in a substitution of valine (V) by aspartate (D) at position 109 (p.V109D).	Aspartic Acid	125-134	intelectin 1	Homo sapiens	71-76
34037423-8	2021	Modifications of the first and second "x" positions of the 2410 Nef dileucine motif to asparagine and aspartic acid residues respectively (ND164), impaired cell surface SERINC5 downregulation, which resulted in reduced infectious virus yield in the presence of SERINC5.	Aspartic Acid	102-115	S100 calcium binding protein B	Homo sapiens	64-67
34037423-8	2021	Modifications of the first and second "x" positions of the 2410 Nef dileucine motif to asparagine and aspartic acid residues respectively (ND164), impaired cell surface SERINC5 downregulation, which resulted in reduced infectious virus yield in the presence of SERINC5.	Aspartic Acid	102-115	serine incorporator 5	Homo sapiens	169-176
34037423-8	2021	Modifications of the first and second "x" positions of the 2410 Nef dileucine motif to asparagine and aspartic acid residues respectively (ND164), impaired cell surface SERINC5 downregulation, which resulted in reduced infectious virus yield in the presence of SERINC5.	Aspartic Acid	102-115	serine incorporator 5	Homo sapiens	261-268
34007191-8	2021	The aspartic acid residue at position 179 in the Omega loop was replaced by a tyrosine residue in the resistant strain, and the plasmid carried a bla KPC-2 to bla KPC-33 mutation.	Aspartic Acid	4-17	UBA domain containing 1	Homo sapiens	150-155
33751015-2	2021	However, their potential role in atmospheric new particle formation (NPF) is poorly understood, especially aspartic acid (ASP), one of the most abundant amino acids in the atmosphere.	Aspartic Acid	107-120	assembly factor for spindle microtubules	Homo sapiens	122-125
33962943-5	2021	The alpha5beta1-fibronectin complex revealed simultaneous interactions at the arginine-glycine-aspartate loop, the synergy site, and a newly identified binding site proximal to adjacent to metal ion-dependent adhesion site, inducing the translocation of helix alpha1 to secure integrin opening.	Aspartic Acid	95-104	fibronectin 1	Homo sapiens	16-27
33658307-6	2021	We find that peptidase and ATPase activities are upregulated in the phospho-mimetic mutant and downregulated in the phospho-dead mutant (S120 mutated to aspartic acid (S120D) or alanine (S120A), respectively).	Aspartic Acid	153-166	dynein, axonemal, heavy chain 8	Mus musculus	27-33
33609439-3	2021	Here, we show that in addition to depleting intracellular aspartate, electron transport chain (ETC) inhibition depletes aspartate-derived asparagine, increases ATF4 levels, and impairs mTOR complex I (mTORC1) activity.	Aspartic Acid	120-129	CREB regulated transcription coactivator 1	Mus musculus	201-207
33713678-3	2021	Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids.	Aspartic Acid	39-42	ETS transcription factor ERG	Homo sapiens	35-38
33497735-0	2021	The mitochondrial aspartate/glutamate carrier (AGC or Aralar1) isoforms in D. melanogaster: Biochemical characterization, gene structure, and evolutionary analysis.	Aspartic Acid	18-27	aralar1	Drosophila melanogaster	54-61
33497735-1	2021	BACKGROUND: In man two mitochondrial aspartate/glutamate carrier (AGC) isoforms, known as aralar and citrin, are required to accomplish several metabolic pathways.	Aspartic Acid	37-46	solute carrier family 25 member 13	Homo sapiens	101-107
33497735-9	2021	CONCLUSIONS: The tight regulation of aralar1 transcripts expression and the high request of aspartate and glutamate during early embryogenesis suggest a crucial role of Aralar1 in this Drosophila developmental stage.	Aspartic Acid	92-101	aralar1	Drosophila melanogaster	169-176
33921837-9	2021	SNP association analysis showed that only SNP rs404360094 in the exon 3 of the CD226 gene, which produces an amino acid substitution from asparagine (uncharged polar) to aspartic acid (acidic), was associated with the three seasonality traits.	Aspartic Acid	170-183	CD226 antigen	Ovis aries	79-84
33891948-4	2021	Similar or lower binding affinities of the modified compounds to the serotonin transporter (SERT) than Vot was observed in the 4-(4-(dimethylamino)-styrl)-N-methylpyridinium (ASP+) uptake assay on RBL-2H3 cells.	Aspartic Acid	175-179	solute carrier family 6 member 4	Rattus norvegicus	69-90
33891948-4	2021	Similar or lower binding affinities of the modified compounds to the serotonin transporter (SERT) than Vot was observed in the 4-(4-(dimethylamino)-styrl)-N-methylpyridinium (ASP+) uptake assay on RBL-2H3 cells.	Aspartic Acid	175-179	solute carrier family 6 member 4	Rattus norvegicus	92-96
33759374-1	2021	BACKGROUND: CITED4 belongs to the CBP/p300-interacting transactivator with glutamic acid and aspartic acid-rich tail (CITED) family which is induced by various cytokines and participates in cytokine-induced proliferation and differentiation.	Aspartic Acid	93-106	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4	Homo sapiens	12-18
33759374-1	2021	BACKGROUND: CITED4 belongs to the CBP/p300-interacting transactivator with glutamic acid and aspartic acid-rich tail (CITED) family which is induced by various cytokines and participates in cytokine-induced proliferation and differentiation.	Aspartic Acid	93-106	CREB binding protein	Homo sapiens	34-38
33759374-1	2021	BACKGROUND: CITED4 belongs to the CBP/p300-interacting transactivator with glutamic acid and aspartic acid-rich tail (CITED) family which is induced by various cytokines and participates in cytokine-induced proliferation and differentiation.	Aspartic Acid	93-106	E1A binding protein p300	Homo sapiens	38-42
33931940-5	2021	The characterization of Fn-modified surfaces showed that Fn grating via phosphonate has led to the highest amount of Fn cell-binding site (RGD, arginine, glycine, and aspartate) available on the surface.	Aspartic Acid	167-176	fibronectin 1	Homo sapiens	24-26
33931940-5	2021	The characterization of Fn-modified surfaces showed that Fn grating via phosphonate has led to the highest amount of Fn cell-binding site (RGD, arginine, glycine, and aspartate) available on the surface.	Aspartic Acid	167-176	fibronectin 1	Homo sapiens	57-59
33931940-5	2021	The characterization of Fn-modified surfaces showed that Fn grating via phosphonate has led to the highest amount of Fn cell-binding site (RGD, arginine, glycine, and aspartate) available on the surface.	Aspartic Acid	167-176	fibronectin 1	Homo sapiens	57-59
33911136-7	2021	In contrast, phosphomimetic mutations (Ser-to-Asp) inhibited PKR activation following either poly (I:C) transfection or virus infection.	Aspartic Acid	46-49	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	61-64
33887099-1	2021	Aspartate/asparagine-beta-hydroxylase (AspH) is a human 2-oxoglutarate (2OG) and Fe(II) oxygenase that catalyzes C3 hydroxylations of aspartate/asparagine residues of epidermal growth factor-like domains (EGFDs).	Aspartic Acid	134-143	aspartate beta-hydroxylase	Homo sapiens	39-43
33887099-2	2021	Unusually, AspH employs two histidine residues to chelate Fe(II) rather than the typical triad of two histidine and one glutamate/aspartate residue.	Aspartic Acid	130-139	aspartate beta-hydroxylase	Homo sapiens	11-15
33871359-2	2021	To characterize the role of apoptotic cell contraction, ROCK1 was rendered caspase non-cleavable (ROCK1nc) by mutating Aspartate 1113, which revealed that ROCK1 cleavage was necessary for forceful contraction and membrane blebbing.	Aspartic Acid	119-128	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	56-61
33859183-1	2021	Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate.	Aspartic Acid	138-147	argininosuccinate synthase 1	Homo sapiens	0-26
34026400-2	2021	To understand the origin of these unique molecular properties of TAT rhodopsin, we mutated Thr82 into Asp, because many microbial rhodopsins contain Asp at the corresponding position as the Schiff base counterion.	Aspartic Acid	102-105	rhodopsin	Homo sapiens	69-78
33857304-10	2021	Substituting phosphomimetic aspartate for serine/threonine residues in the Gln3 URS abolishes the N-terminal Gln3-Tor1 interaction, rapamycin-elicited nuclear Gln3 localization, and 1/2 of the derepressed levels of nuclear Gln3 localization.	Aspartic Acid	28-37	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	75-79
33857304-10	2021	Substituting phosphomimetic aspartate for serine/threonine residues in the Gln3 URS abolishes the N-terminal Gln3-Tor1 interaction, rapamycin-elicited nuclear Gln3 localization, and 1/2 of the derepressed levels of nuclear Gln3 localization.	Aspartic Acid	28-37	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	109-113
33857304-10	2021	Substituting phosphomimetic aspartate for serine/threonine residues in the Gln3 URS abolishes the N-terminal Gln3-Tor1 interaction, rapamycin-elicited nuclear Gln3 localization, and 1/2 of the derepressed levels of nuclear Gln3 localization.	Aspartic Acid	28-37	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	114-118
33857304-10	2021	Substituting phosphomimetic aspartate for serine/threonine residues in the Gln3 URS abolishes the N-terminal Gln3-Tor1 interaction, rapamycin-elicited nuclear Gln3 localization, and 1/2 of the derepressed levels of nuclear Gln3 localization.	Aspartic Acid	28-37	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	109-113
33857304-10	2021	Substituting phosphomimetic aspartate for serine/threonine residues in the Gln3 URS abolishes the N-terminal Gln3-Tor1 interaction, rapamycin-elicited nuclear Gln3 localization, and 1/2 of the derepressed levels of nuclear Gln3 localization.	Aspartic Acid	28-37	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	109-113
33859183-1	2021	Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate.	Aspartic Acid	138-147	argininosuccinate synthase 1	Homo sapiens	28-32
33388257-5	2021	The interactions were generated between 5-M-2-MB and specific amino acid residues (Trp-358, Thr-308, Glu-356, and Asp-357) located on the A chain of tyrosinase.	Aspartic Acid	114-117	tyrosinase	Homo sapiens	149-159
33570571-5	2021	SNT-3 possesses canonical aspartate residues in both C2 domains, but lacks an N-terminal transmembrane (TM) domain.	Aspartic Acid	26-35	SyNapTotagmin	Caenorhabditis elegans	0-5
33063293-10	2021	SCA1 revealed a decrease of aspartate (Asp) in the vermis (62%) and an elevation in the prefrontal cortex (130%) as well as an elevation of myo-inositol (Ins) in the cerebellar hemisphere (51%) and pons (46%).	Aspartic Acid	28-37	ataxin 1	Homo sapiens	0-4
33063293-10	2021	SCA1 revealed a decrease of aspartate (Asp) in the vermis (62%) and an elevation in the prefrontal cortex (130%) as well as an elevation of myo-inositol (Ins) in the cerebellar hemisphere (51%) and pons (46%).	Aspartic Acid	39-42	ataxin 1	Homo sapiens	0-4
32577988-7	2021	In patients with ischemic heart disease, low plasma levels of PCSK9 and elevated levels of HS-CRP are independent predictors of ASP.	Aspartic Acid	128-131	proprotein convertase subtilisin/kexin type 9	Homo sapiens	62-67
32577988-7	2021	In patients with ischemic heart disease, low plasma levels of PCSK9 and elevated levels of HS-CRP are independent predictors of ASP.	Aspartic Acid	128-131	C-reactive protein	Homo sapiens	94-97
33857260-3	2021	We have reported that the structure and function of an alphaA66-80 peptide, corresponding to the 66-80 (66SDRDKFVIFLDVKHF80) fragment of human lens alphaA-crystallin, was dramatically altered by the isomerization of aspartate residue (Asp) at position 76.	Aspartic Acid	216-225	assembly factor for spindle microtubules	Homo sapiens	235-238
33843816-7	2021	Patients having high serum Cystatin-C were older in age and having higher serum levels of aspartate aminotransferases and urea.	Aspartic Acid	90-99	cystatin C	Homo sapiens	27-37
33506493-8	2021	In alpha4beta2 nAChR, the arginine forms a salt-bridge with an aspartate residue in loop B that is necessary for receptor expression, whereas in alpha7 nAChR, this residue is not stabilised by electrostatic interactions, making its side chain highly mobile.	Aspartic Acid	63-72	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	15-20
33675096-1	2021	BACKGROUND: The aim of this study is to evaluate the relationship between the aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) ratio and local disease control in patients with head and neck squamous cell carcinomas (HNSCC) treated with radiotherapy/chemoradiotherapy.	Aspartic Acid	78-87	solute carrier family 17 member 5	Homo sapiens	107-110
33790305-9	2021	But, aspartic acid intake had a negative correlation with PDR.	Aspartic Acid	5-18	PDR	Homo sapiens	58-61
33790305-11	2021	However, lower aspartic acid intake affected the PDR incidence.	Aspartic Acid	15-28	PDR	Homo sapiens	49-52
33755704-10	2021	Notably, we have found a D614G (aspartic acid to glycine) mutation in spike protein of the sequences from the GH clade.	Aspartic Acid	32-45	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	70-75
33755704-10	2021	Notably, we have found a D614G (aspartic acid to glycine) mutation in spike protein of the sequences from the GH clade.	Aspartic Acid	32-45	gamma-glutamyl hydrolase	Homo sapiens	110-112
33928245-4	2021	Quantitative assessment of amyloid-beta N-terminus revealed that > 80% of aspartates (Asp-1 and Asp-7) in the N-terminus was isomerized, making isomerization the most dominant post-translational modification of amyloid-beta in Alzheimer"s disease brain.	Aspartic Acid	74-84	amyloid beta precursor protein	Homo sapiens	27-39
33928245-4	2021	Quantitative assessment of amyloid-beta N-terminus revealed that > 80% of aspartates (Asp-1 and Asp-7) in the N-terminus was isomerized, making isomerization the most dominant post-translational modification of amyloid-beta in Alzheimer"s disease brain.	Aspartic Acid	74-84	beta-secretase 2	Homo sapiens	86-91
33928245-5	2021	Total amyloid-beta1-15 was ~85% isomerized at Asp-1 and/or Asp-7 residues, with only 15% unmodified amyloid-beta1-15 left in Alzheimer"s disease.	Aspartic Acid	46-49	BCL2 related protein A1	Homo sapiens	14-22
33911966-1	2021	L-Asparaginase is an antileukemic agent that depletes L-asparagine "an important nutrient for cancer cells" through the hydrolysis of L-asparagine into L-aspartic acid and ammonia leading to leukemia cell starvation and apoptosis in susceptible leukemic cell populations.	Aspartic Acid	152-167	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
33709700-5	2021	By profiling O-GlcNAc in cell extracts and probing glycosylation of purified substrates, we show here that ladders of asparagines and aspartates that extend the full length of OGT"s TPR lumen control substrate glycosylation.	Aspartic Acid	134-144	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	176-179
33634309-5	2021	Two aspartic acid residues in partially buried salt-bridges (D290-R273 and R355-D398) have pKas that are calculated to be elevated and destabilizing in more open forms of the spike trimer.	Aspartic Acid	4-17	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	175-180
33737524-6	2021	In comparison to untreated controls, treatment of EJ28Luc cells with 213Bi-anti-EGFR-MAb resulted in a significantly decreased incorporation of 13C from [U-13C6]glucose into alanine, aspartate, glutamate, glycine, proline and serine.	Aspartic Acid	183-192	epidermal growth factor receptor	Homo sapiens	80-84
33722201-4	2021	The purpose of the current study was to determine the biological significance of the putative aatJ-aatQMP operon and its regulatory aauR and rpoN genes in the utilization of L-glutamate, L-glutamine, L-aspartate and L-asparagine in Pseudomonas aeruginosa PAO1.	Aspartic Acid	200-211	RNA polymerase factor sigma-54	Pseudomonas aeruginosa PAO1	141-145
33722201-8	2021	Subsequent analysis of beta-galactosidase reporters revealed that both aatJ and aatQ were induced in response to L-glutamate, L-glutamine, L-aspartate or L-asparagine in a manner dependent on the aauR and rpoN genes.	Aspartic Acid	139-150	RNA polymerase factor sigma-54	Pseudomonas aeruginosa PAO1	205-209
33529484-4	2021	Molecular docking and molecular dynamics simulations suggest that interactions with Glu 39, Glu 78, Arg 111, Pro 137, Asp 251 and His 252 are an important factor for inhibitors affinity toward the DNase I.	Aspartic Acid	118-121	deoxyribonuclease 1	Homo sapiens	197-204
33658209-2	2021	Here, we report cryo-EM structures of hEAAT3 in several functional states where the transporter is empty, bound to coupled sodium ions only, or fully loaded with three sodium ions, a proton, and the substrate aspartate.	Aspartic Acid	209-218	solute carrier family 1 member 1	Homo sapiens	38-44
33434682-3	2021	Aging of elastin and elastic fibers involves enzymatic degradation, oxidative damage, glycation, calcification, aspartic acid racemization, binding of lipids and lipid peroxidation products, carbamylation and mechanical fatigue.	Aspartic Acid	112-125	elastin	Homo sapiens	9-16
33444662-6	2021	It is known that Asp-146 is required for selenocysteine specificity in the human selenocysteine lyase.	Aspartic Acid	17-20	selenocysteine lyase	Homo sapiens	81-101
33404402-1	2021	Molybdenum dioxide-gadolinium-arginine/glycine/aspartic acid (MoS2-Gd-RGD) sequences targeting nano-contrast agents that specifically bind to human hepatocellular carcinoma (HCC) HepG2 cells were synthesized, and their targeting imaging effects on HCC cells and models were evaluated.	Aspartic Acid	47-60	mago homolog, exon junction complex core component	Mus musculus	62-66
33995953-1	2021	Objectives: We investigated whether NOS3-c.894G>T transversion (rs1799983), which causes the substitution of glutamate with aspartate (E298D) in the oxygenase domain of endothelial nitric oxide synthase (eNOS), is associated with susceptibility to metabolic syndrome (MetS) risk in Iranian-Azerbaijanis.	Aspartic Acid	124-133	nitric oxide synthase 3	Homo sapiens	36-40
33995953-1	2021	Objectives: We investigated whether NOS3-c.894G>T transversion (rs1799983), which causes the substitution of glutamate with aspartate (E298D) in the oxygenase domain of endothelial nitric oxide synthase (eNOS), is associated with susceptibility to metabolic syndrome (MetS) risk in Iranian-Azerbaijanis.	Aspartic Acid	124-133	nitric oxide synthase 3	Homo sapiens	169-202
33995953-1	2021	Objectives: We investigated whether NOS3-c.894G>T transversion (rs1799983), which causes the substitution of glutamate with aspartate (E298D) in the oxygenase domain of endothelial nitric oxide synthase (eNOS), is associated with susceptibility to metabolic syndrome (MetS) risk in Iranian-Azerbaijanis.	Aspartic Acid	124-133	nitric oxide synthase 3	Homo sapiens	204-208
33481349-6	2021	Tumor necrosis factor alpha-treatment (TNFalpha) of HUVECs causes increases in asparagine and decreases in aspartate concentrations.	Aspartic Acid	107-116	tumor necrosis factor	Homo sapiens	0-27
33389490-4	2021	NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome.	Aspartic Acid	172-185	NLR family pyrin domain containing 3	Homo sapiens	0-5
33389490-4	2021	NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome.	Aspartic Acid	172-185	atrophin 1	Homo sapiens	7-10
33389490-4	2021	NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome.	Aspartic Acid	172-185	caspase 1	Homo sapiens	195-224
33389490-4	2021	NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome.	Aspartic Acid	172-185	NLR family pyrin domain containing 3	Homo sapiens	243-248
33481349-6	2021	Tumor necrosis factor alpha-treatment (TNFalpha) of HUVECs causes increases in asparagine and decreases in aspartate concentrations.	Aspartic Acid	107-116	tumor necrosis factor	Homo sapiens	39-47
33635895-11	2021	Molecular docking and molecular dynamic (MD) studies indicate that interaction with Trp32 of SOD1 is predicted to be weak and that there was hydrogen bonding with the nearby aspartate (Asp96), potentiating the Trp32-uracil interaction.	Aspartic Acid	174-183	superoxide dismutase 1	Homo sapiens	93-97
33576751-1	2021	Electrochemical and spectroscopic studies demonstrated that the N-truncated amyloid beta peptide Abeta5-9 (Arg-His-Asp-Ser-Gly-NH2) possessing histidine at position 2 (His-2) formed ternary complexes with copper(ii) and phosphate anions or phosphate groups of biomolecules.	Aspartic Acid	115-118	histatin 3	Homo sapiens	168-173
33596708-3	2021	Moreover, postoperative infection is an important factor affecting bone healing.AcN-RADARADARADARADA-CONH2 (RADA) is a new type of self-assembling peptide(SAP) composed of Arg,Ala,Asp and other amino acids was designed and prepared.	Aspartic Acid	180-183	SH2 domain containing 1A	Homo sapiens	155-158
33492128-4	2021	Mechanistic studies of DDAH inactivation by 4,4-dipyridylsulfide reveal selective covalent S-pyridinylation of the active-site Cys through catalysis by a neighboring Asp residue.	Aspartic Acid	166-169	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	23-27
33611850-1	2021	HLA-DPA1*01:46 differs from HLA-DPA1*01:03 in exon 2 at amino acid 85; Aspartate to Asparagine substitution.	Aspartic Acid	71-80	major histocompatibility complex, class II, DP alpha 1	Homo sapiens	0-8
33333092-5	2021	Since OGT tetratricopeptide repeat (TPR) domain plays a key role in OGT-OGA binding, we screened 30 OGT TPR mutants, which revealed 15 "ladder like" asparagine or aspartate residues spanning TPRs 3-7 and 10-13.5 that affect OGA O-GlcNAcylation.	Aspartic Acid	163-172	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	6-9
33644578-3	2021	Herein, we demonstrated that the coupling reagent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) can mediate intramolecular cyclization of aspartic acid to form succinimide efficiently in the LL37-derived short antimicrobial peptide KR12.	Aspartic Acid	167-180	cathelicidin antimicrobial peptide	Homo sapiens	220-224
33598458-2	2020	Tryptophan-aspartic acid (W-D) repeat containing planar cell polarity effector (WDPCP) has been proven to be an essential element for ciliogenesis in human nasal epithelium, but its role in the beating of cilia remains unclear.	Aspartic Acid	11-24	WD repeat containing planar cell polarity effector	Homo sapiens	80-85
33333092-5	2021	Since OGT tetratricopeptide repeat (TPR) domain plays a key role in OGT-OGA binding, we screened 30 OGT TPR mutants, which revealed 15 "ladder like" asparagine or aspartate residues spanning TPRs 3-7 and 10-13.5 that affect OGA O-GlcNAcylation.	Aspartic Acid	163-172	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	68-71
33333092-5	2021	Since OGT tetratricopeptide repeat (TPR) domain plays a key role in OGT-OGA binding, we screened 30 OGT TPR mutants, which revealed 15 "ladder like" asparagine or aspartate residues spanning TPRs 3-7 and 10-13.5 that affect OGA O-GlcNAcylation.	Aspartic Acid	163-172	O-GlcNAcase	Homo sapiens	72-75
33333092-5	2021	Since OGT tetratricopeptide repeat (TPR) domain plays a key role in OGT-OGA binding, we screened 30 OGT TPR mutants, which revealed 15 "ladder like" asparagine or aspartate residues spanning TPRs 3-7 and 10-13.5 that affect OGA O-GlcNAcylation.	Aspartic Acid	163-172	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	68-71
33373587-5	2021	L685,458 directly coordinates the two catalytic aspartate residues of PS1.	Aspartic Acid	48-57	presenilin 1	Homo sapiens	70-73
33320167-5	2021	We show that, whereas extracellular acid inhibits agonist-induced TRPV3 activation through an aspartate residue (D641) in the selectivity filter, intracellular protons sensitize the channel through cytoplasmic C-terminal glutamate and aspartate residues (E682, E689, and D727).	Aspartic Acid	94-103	transient receptor potential cation channel subfamily V member 3	Homo sapiens	66-71
33448281-2	2021	Although all caspases prefer aspartate at the P1 position of the substrate, the caspase-6 subfamily shows preference for valine at the P4 position, while caspase-3 shows preference for aspartate.	Aspartic Acid	29-38	caspase 6, apoptosis-related cysteine peptidase a	Danio rerio	13-21
33527205-5	2021	Few experimental studies have reported that in vitro mutation of Serine-615 (S615D) and Serine-633 (S633D) in the FMN reductase sub-domain to aspartic acid increased NO production and increased Ca2+ sensitivity.	Aspartic Acid	142-155	formin 1	Homo sapiens	114-117
33527205-12	2021	Serine-615 and Serine-633 in the auto-inhibitory loop of human eNOS reductase model was mutated to aspartic acid in silico and molecular dynamics simulations of the protein showed that steric hindrance due to mutation altered the auto-inhibitory loop rearrangement and the FMN sub-domain movement favouring electron transfer.	Aspartic Acid	99-112	formin 1	Homo sapiens	273-276
33448281-2	2021	Although all caspases prefer aspartate at the P1 position of the substrate, the caspase-6 subfamily shows preference for valine at the P4 position, while caspase-3 shows preference for aspartate.	Aspartic Acid	185-194	caspase 6, apoptosis-related cysteine peptidase a	Danio rerio	80-89
33448281-2	2021	Although all caspases prefer aspartate at the P1 position of the substrate, the caspase-6 subfamily shows preference for valine at the P4 position, while caspase-3 shows preference for aspartate.	Aspartic Acid	185-194	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	154-163
33167196-3	2021	Conversely, the aminopeptidase responsible for the removal of the N-terminal Asp residue of statherin was not active in preterm newborns, becoming active only several months after the normal term of delivery.	Aspartic Acid	77-80	statherin	Homo sapiens	92-101
32710115-10	2021	Accumulation of high amounts of aspartate and the impaired growth phenotype of OMT1 rice lines could be suppressed by simultaneous over-expression of ZmDiT2.	Aspartic Acid	32-41	anthranilic acid methyltransferase 1	Zea mays	79-83
33385956-6	2021	Molecular modeling studies of 22d docked inside the Sph binding pocket of both SphK1 and SphK2 indicate essential hydrogen bond between the 2-(hydroxymethyl)pyrrolidine head to interact with aspartic acid and serine residues near the ATP binding pocket, which provide the basis for dual inhibition.	Aspartic Acid	191-204	sphingosine kinase 2	Homo sapiens	89-94
33498225-3	2021	This potential is suggested on the basis of the emergence of an RGD (arginine-glycine-aspartate) sequence in the receptor-binding domain of the spike protein.	Aspartic Acid	86-95	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	144-149
33385956-6	2021	Molecular modeling studies of 22d docked inside the Sph binding pocket of both SphK1 and SphK2 indicate essential hydrogen bond between the 2-(hydroxymethyl)pyrrolidine head to interact with aspartic acid and serine residues near the ATP binding pocket, which provide the basis for dual inhibition.	Aspartic Acid	191-204	sphingosine kinase 1	Homo sapiens	79-84
33419840-1	2021	BACKGROUND/AIM: The Aspartate aminotransaminase/Alanine aminotransaminase ratio (AST/ALT ratio) has been identified as a prognostic marker for several malignancies.	Aspartic Acid	20-29	solute carrier family 17 member 5	Homo sapiens	81-84
33105479-5	2021	To gain insights into disease biology, we biochemically characterized missense variants within the conserved N-terminal aspartic acid-histidine-histidine (DHH) motif and provide evidence that they result in the destabilization of protein structure and/or loss of exopolyphosphatase activity.	Aspartic Acid	120-133	desert hedgehog signaling molecule	Homo sapiens	155-158
33130280-7	2021	The catalytic triad consisting of Serine-441, Histidine-296 and Aspartic acid-345 was identified as active binding site of TMPRSS2 using existing ligands.	Aspartic Acid	64-77	transmembrane serine protease 2	Homo sapiens	123-130
33518769-1	2021	Asparagine synthetase catalyses the transfer of an amino group from glutamine to aspartate to form glutamate and asparagine.	Aspartic Acid	81-90	LOC100856906	Zea mays	0-21
32830360-9	2021	This produces different accessibility of water molecules for the catalytic aspartates of PS1, critical for Abeta production.	Aspartic Acid	75-85	presenilin 1	Homo sapiens	89-92
32869129-4	2021	To further investigate the effects of HSP90 cleavage on cells, we introduced mutations to the potential cleavage sites of HSP90beta and found that the 294th aspartic acid residue of the protein was mainly cleaved.	Aspartic Acid	157-170	heat shock protein 90 alpha family class A member 1	Homo sapiens	38-43
32869129-4	2021	To further investigate the effects of HSP90 cleavage on cells, we introduced mutations to the potential cleavage sites of HSP90beta and found that the 294th aspartic acid residue of the protein was mainly cleaved.	Aspartic Acid	157-170	heat shock protein 90 alpha family class A member 1	Homo sapiens	122-131
32074607-5	2021	PTPN2 scores were correlated to sustained virologic response after DAA therapy, viral load, serum levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase (GGT), and the Model for End-Stage Liver Disease (MELD) score at the time of liver biopsy.	Aspartic Acid	134-143	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	0-5
32936424-7	2021	A total of 33 upregulated and 52 downregulated genes associated with HCC progression and ferroptosis were obtained, and these genes were significantly involved in the negative regulation of ERK1 and ERK2 cascades; the NAD biosynthetic process; alanine, aspartate, and glutamate metabolism; and other pathways.	Aspartic Acid	253-262	mitogen-activated protein kinase 3	Homo sapiens	190-194
32936424-7	2021	A total of 33 upregulated and 52 downregulated genes associated with HCC progression and ferroptosis were obtained, and these genes were significantly involved in the negative regulation of ERK1 and ERK2 cascades; the NAD biosynthetic process; alanine, aspartate, and glutamate metabolism; and other pathways.	Aspartic Acid	253-262	mitogen-activated protein kinase 1	Homo sapiens	199-203
32936424-12	2021	These genes played roles in HCC progression and ferroptosis via the negative regulation of the ERK1 and ERK2 cascades; the NAD biosynthetic process; and alanine, aspartate, and glutamate metabolism.	Aspartic Acid	162-171	mitogen-activated protein kinase 3	Homo sapiens	95-99
32936424-12	2021	These genes played roles in HCC progression and ferroptosis via the negative regulation of the ERK1 and ERK2 cascades; the NAD biosynthetic process; and alanine, aspartate, and glutamate metabolism.	Aspartic Acid	162-171	mitogen-activated protein kinase 1	Homo sapiens	104-108
33475951-7	2021	The characteristic 1H-13C chemical shift correlations of isoAsp, N-terminal Pro and C-terminal Asp under standardized conditions were used to identify these PTMs in lysozyme and in the therapeutic mAb rituximab (MabThera) upon prolonged storage under acidic conditions (pH 4-5) and 40  C. The results show that the application of our 2D NMR-based protocol is straightforward and allows detecting chemical changes of proteins that may be otherwise unnoticed with other analytical methods.	Aspartic Acid	60-63	lysozyme	Homo sapiens	165-173
32830360-9	2021	This produces different accessibility of water molecules for the catalytic aspartates of PS1, critical for Abeta production.	Aspartic Acid	75-85	amyloid beta precursor protein	Homo sapiens	107-112
32830360-10	2021	In particular, we find that the typical distance between the catalytic aspartates of PS1 and the C83 cleavage sites are shorter in APH-1B, that is, it represents a more closed state, due to interactions with the C-terminal fragment of PS1.	Aspartic Acid	71-81	presenilin 1	Homo sapiens	85-88
32830360-10	2021	In particular, we find that the typical distance between the catalytic aspartates of PS1 and the C83 cleavage sites are shorter in APH-1B, that is, it represents a more closed state, due to interactions with the C-terminal fragment of PS1.	Aspartic Acid	71-81	aph-1 homolog B, gamma-secretase subunit	Homo sapiens	131-137
32830360-10	2021	In particular, we find that the typical distance between the catalytic aspartates of PS1 and the C83 cleavage sites are shorter in APH-1B, that is, it represents a more closed state, due to interactions with the C-terminal fragment of PS1.	Aspartic Acid	71-81	presenilin 1	Homo sapiens	235-238
32740958-2	2021	Citrin is a component of the malate-aspartate nicotinamide adenine dinucleotide hydrogen (NADH) shuttle, an essential shuttle for hepatic glycolysis.	Aspartic Acid	36-45	solute carrier family 25 member 13	Homo sapiens	0-6
32986951-2	2021	Two of the most frequent oncogenic KRAS mutations observed in patients result in glycine to aspartic acid substitution at either codon 12 (G12D) or 13 (G13D).	Aspartic Acid	92-105	KRAS proto-oncogene, GTPase	Homo sapiens	35-39
33255056-2	2021	The arginine-glycine-aspartic acid (RGD) sequence is present in several ECM proteins, such as fibronectin, collagen type I, fibrinogen, laminin, vitronectin, and osteopontin.	Aspartic Acid	21-34	fibronectin 1	Homo sapiens	94-105
33255056-2	2021	The arginine-glycine-aspartic acid (RGD) sequence is present in several ECM proteins, such as fibronectin, collagen type I, fibrinogen, laminin, vitronectin, and osteopontin.	Aspartic Acid	21-34	fibrinogen beta chain	Homo sapiens	124-134
33255056-2	2021	The arginine-glycine-aspartic acid (RGD) sequence is present in several ECM proteins, such as fibronectin, collagen type I, fibrinogen, laminin, vitronectin, and osteopontin.	Aspartic Acid	21-34	vitronectin	Homo sapiens	145-156
33255056-2	2021	The arginine-glycine-aspartic acid (RGD) sequence is present in several ECM proteins, such as fibronectin, collagen type I, fibrinogen, laminin, vitronectin, and osteopontin.	Aspartic Acid	21-34	secreted phosphoprotein 1	Homo sapiens	162-173
33217155-2	2021	It is caused by homozygous/compound heterozygous variants in the aspartate/asparagine-beta-hydroxylase (ASPH) gene, which hydroxylates the aspartic acid and asparagine in epidermal growth factor-like domains of various proteins.	Aspartic Acid	139-152	aspartate beta-hydroxylase	Homo sapiens	104-108
34033101-6	2021	These include cleavage of GSDM D and E, activation and release of IL-1beta and IL-18, and activation of cysteinyl aspartate specific proteinase (caspase-1, -3, -4, -5, and -11).	Aspartic Acid	114-123	caspase 1	Homo sapiens	145-175
33253826-8	2021	The results of Western blot assay revealed that protein expressions of GluN1 (but not GluN2B) subunit of N-methyl-D-aspartate receptors in the DS and NAc were higher in the HI group than in the LI group.	Aspartic Acid	116-125	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	71-76
33406522-8	2021	A single amino acid aspartate-454, that causes dissociation of the RBD of the spike and ACE2, and F486 which gives the strength of binding with ACE2 remain intact in all coronaviruses.	Aspartic Acid	20-29	angiotensin converting enzyme 2	Homo sapiens	88-92
33073469-6	2021	In addition, transient coexpression experiments in Arabidopsis protoplasts revealed that effector constructs expressing a mutant variant of AtERF72, AtERF72S151D (carrying a Ser to aspartic acid [Asp] substitution at amino acid position 151), showed higher expression of the beta-glucuronidase (GUS) reporter gene driven by the GCC box element than effector constructs expressing the wild-type AtERF72.	Aspartic Acid	196-199	ethylene-responsive element binding protein	Arabidopsis thaliana	140-147
33396807-1	2020	Previous work has shown that the Tat protein of Human Immunodeficiency Virus (HIV)-1 is released by acutely infected cells in a biologically active form and enters dendritic cells upon the binding of its arginine-glycine-aspartic acid (RGD) domain to the alpha5beta1, alphavbeta3, and alphavbeta5 integrins.	Aspartic Acid	221-234	tyrosine aminotransferase	Homo sapiens	33-36
33506114-5	2021	The second and the dominant variant, represented by 62%, showed aspartate a coil amino acid substitution to glycine an extracellular amino acid at D614G located in the spike recognition binding site.	Aspartic Acid	64-73	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	168-173
33073469-6	2021	In addition, transient coexpression experiments in Arabidopsis protoplasts revealed that effector constructs expressing a mutant variant of AtERF72, AtERF72S151D (carrying a Ser to aspartic acid [Asp] substitution at amino acid position 151), showed higher expression of the beta-glucuronidase (GUS) reporter gene driven by the GCC box element than effector constructs expressing the wild-type AtERF72.	Aspartic Acid	181-194	ethylene-responsive element binding protein	Arabidopsis thaliana	140-147
33374431-11	2020	In addition, asparagine at codon 166 of cat PrP was predicted to have longer hydrogen bond than aspartic acid at codon 163 of canine PrP.	Aspartic Acid	96-109	prion protein	Canis lupus familiaris	44-47
33374431-11	2020	In addition, asparagine at codon 166 of cat PrP was predicted to have longer hydrogen bond than aspartic acid at codon 163 of canine PrP.	Aspartic Acid	96-109	prion protein	Canis lupus familiaris	133-136
33406522-8	2021	A single amino acid aspartate-454, that causes dissociation of the RBD of the spike and ACE2, and F486 which gives the strength of binding with ACE2 remain intact in all coronaviruses.	Aspartic Acid	20-29	angiotensin converting enzyme 2	Homo sapiens	144-148
33280590-10	2022	RESULTS: Eight amino acid levels (methionine, arginine, cystine, glutamine, proline, asparagine, serine, aspartate) were significantly altered in patients with neurofibromatosis type 1.	Aspartic Acid	105-114	neurofibromin 1	Homo sapiens	160-184
33293370-7	2021	In contrast, the phosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wildtype EWSR1/FLI1.	Aspartic Acid	63-76	EWS RNA binding protein 1	Homo sapiens	39-44
33293370-7	2021	In contrast, the phosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wildtype EWSR1/FLI1.	Aspartic Acid	63-76	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	45-49
33293370-7	2021	In contrast, the phosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wildtype EWSR1/FLI1.	Aspartic Acid	63-76	EWS RNA binding protein 1	Homo sapiens	123-128
33293370-7	2021	In contrast, the phosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wildtype EWSR1/FLI1.	Aspartic Acid	63-76	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	129-133
33293370-7	2021	In contrast, the phosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wildtype EWSR1/FLI1.	Aspartic Acid	78-81	EWS RNA binding protein 1	Homo sapiens	39-44
33293370-7	2021	In contrast, the phosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wildtype EWSR1/FLI1.	Aspartic Acid	78-81	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	45-49
33293370-7	2021	In contrast, the phosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wildtype EWSR1/FLI1.	Aspartic Acid	78-81	EWS RNA binding protein 1	Homo sapiens	123-128
33426238-1	2021	Introduction: This study aimed to examine the bone-forming ability of medium-cross-linked recombinant collagen peptide (mRCP) particles developedbased on human collagen type I, contains an arginyl-glycyl-aspartic acid-rich motif, fabricated as bone filling material, compared to that of the autologous bone graft.	Aspartic Acid	204-217	RAB11 family interacting protein 1 (class I)	Mus musculus	120-124
33230296-0	2020	KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth.	Aspartic Acid	59-68	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
33343327-4	2020	Interestingly, this gene cluster contains a non-synonymous single-nucleotide polymorphism (SNP) in the human CHRNA5 gene, causing an aspartic acid (D) to asparagine (N) substitution at amino acid position 398 in the alpha5 nAChR subunit.	Aspartic Acid	133-146	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	109-115
33343327-4	2020	Interestingly, this gene cluster contains a non-synonymous single-nucleotide polymorphism (SNP) in the human CHRNA5 gene, causing an aspartic acid (D) to asparagine (N) substitution at amino acid position 398 in the alpha5 nAChR subunit.	Aspartic Acid	133-146	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	223-228
33276429-7	2020	Moreover, phosphomimetic mutation of either T302 or S328 to aspartate prevented the mechanical stretch-induced activation of Panx1 channels.	Aspartic Acid	60-69	pannexin 1	Homo sapiens	125-130
32697037-8	2020	Interaction of amino acids in protective alleles namely B*35:01:01 and DRB1*04:03:01 has revealed that aspartic acid at 114th (D) position in mature HLA-B protein and glutamic acid (E) at 74th position of mature HLA-DRB1 protein have a combined effect in protecting against the disease.	Aspartic Acid	103-116	major histocompatibility complex, class II, DR beta 1	Homo sapiens	71-75
32697037-8	2020	Interaction of amino acids in protective alleles namely B*35:01:01 and DRB1*04:03:01 has revealed that aspartic acid at 114th (D) position in mature HLA-B protein and glutamic acid (E) at 74th position of mature HLA-DRB1 protein have a combined effect in protecting against the disease.	Aspartic Acid	103-116	major histocompatibility complex, class I, B	Homo sapiens	149-154
33065161-10	2020	Surprisingly, aspartate was almost completely depleted after cold exposure in UCP1-KO mice.	Aspartic Acid	14-23	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	78-82
33065161-11	2020	Gene expression analysis suggested that aspartate was actively utilized after cold exposure both in WT and UCP1-KO mice, but it was replenished from intracellular N-acetyl-aspartate in WT mice.	Aspartic Acid	40-49	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	107-111
33230296-0	2020	KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth.	Aspartic Acid	59-68	uncoupling protein 2	Homo sapiens	45-49
33230296-8	2020	Collectively, these results demonstrate that UCP2 plays a vital role in PDAC, since its aspartate transport activity connects the mitochondrial and cytosolic reactions necessary for KRASmut rewired glutamine metabolism2, and thus it should be considered a key metabolic target for the treatment of this refractory tumour.	Aspartic Acid	88-97	uncoupling protein 2	Homo sapiens	45-49
33260771-11	2020	LIC11112, LIC20143, and LIC11037 have the serine protease domain with the conserved catalytic triad His-Asp-Ser.	Aspartic Acid	104-107	coagulation factor II, thrombin	Homo sapiens	42-57
33248600-9	2020	Reduced neAA concentrations in CP160 decreased ADG and G:F. Supplementation of Asp+Asn, Glu, and Glu+Gln to CP160 increased ADG and G:F, but not to the level found for CP180.	Aspartic Acid	79-82	ADG	Gallus gallus	124-127
33248600-11	2020	Supplementation of Asp+Asn caused higher ADG and G:F than supplementation of Asp alone.	Aspartic Acid	19-22	ADG	Gallus gallus	41-44
33292758-0	2020	Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis.	Aspartic Acid	21-30	solute carrier family 25 member 12	Homo sapiens	49-57
33087477-1	2020	Aralar/AGC1/Slc25a12, the mitochondrial aspartate-glutamate carrier expressed in neurons, is the regulatory component of the NADH malate-aspartate shuttle.	Aspartic Acid	40-49	aggrecan	Mus musculus	7-11
33292758-3	2020	We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD+/NADH ratio, mitochondrial respiration, and tumor growth.	Aspartic Acid	37-46	solute carrier family 25 member 12	Homo sapiens	68-76
33292758-3	2020	We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD+/NADH ratio, mitochondrial respiration, and tumor growth.	Aspartic Acid	37-46	solute carrier family 25 member 12	Homo sapiens	80-84
33292758-3	2020	We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD+/NADH ratio, mitochondrial respiration, and tumor growth.	Aspartic Acid	124-133	solute carrier family 25 member 12	Homo sapiens	68-76
33292758-3	2020	We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD+/NADH ratio, mitochondrial respiration, and tumor growth.	Aspartic Acid	124-133	solute carrier family 25 member 12	Homo sapiens	80-84
33292758-3	2020	We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD+/NADH ratio, mitochondrial respiration, and tumor growth.	Aspartic Acid	124-133	solute carrier family 25 member 12	Homo sapiens	68-76
33292758-3	2020	We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD+/NADH ratio, mitochondrial respiration, and tumor growth.	Aspartic Acid	124-133	solute carrier family 25 member 12	Homo sapiens	80-84
33087477-1	2020	Aralar/AGC1/Slc25a12, the mitochondrial aspartate-glutamate carrier expressed in neurons, is the regulatory component of the NADH malate-aspartate shuttle.	Aspartic Acid	40-49	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	12-20
33087477-1	2020	Aralar/AGC1/Slc25a12, the mitochondrial aspartate-glutamate carrier expressed in neurons, is the regulatory component of the NADH malate-aspartate shuttle.	Aspartic Acid	137-146	aggrecan	Mus musculus	7-11
33087477-1	2020	Aralar/AGC1/Slc25a12, the mitochondrial aspartate-glutamate carrier expressed in neurons, is the regulatory component of the NADH malate-aspartate shuttle.	Aspartic Acid	137-146	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	12-20
33214970-13	2020	Three individuals had Asparagine Aspartic Acid mutation at position 376 (A G), of which G6PD A(+) and G6PD A(-) were present in two and one cases, respectively.	Aspartic Acid	33-46	glucose-6-phosphate dehydrogenase	Homo sapiens	88-92
33166460-1	2020	Bacterial tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the modified tRNA nucleoside queuosine present in the anticodon wobble position of tRNAs specific for aspartate, asparagine, histidine, and tyrosine.	Aspartic Acid	183-192	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	41-44
33007563-7	2020	In silico molecular docking and dynamics simulation studies of leads suggested their consensual binding affinity toward PAS-AChE in addition to aspartate dyad of BACE-1.	Aspartic Acid	144-153	beta-secretase 1	Homo sapiens	162-168
33166460-1	2020	Bacterial tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the modified tRNA nucleoside queuosine present in the anticodon wobble position of tRNAs specific for aspartate, asparagine, histidine, and tyrosine.	Aspartic Acid	183-192	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	10-39
33208362-5	2020	We further demonstrate that GSDMD inactivation by apoptotic caspases at aspartate 88 (D88) suppresses TNF-induced lethality but promotes anti-Yersinia defense.	Aspartic Acid	72-81	gasdermin D	Homo sapiens	28-33
33208362-5	2020	We further demonstrate that GSDMD inactivation by apoptotic caspases at aspartate 88 (D88) suppresses TNF-induced lethality but promotes anti-Yersinia defense.	Aspartic Acid	72-81	caspase 1	Homo sapiens	60-68
33208362-5	2020	We further demonstrate that GSDMD inactivation by apoptotic caspases at aspartate 88 (D88) suppresses TNF-induced lethality but promotes anti-Yersinia defense.	Aspartic Acid	72-81	tumor necrosis factor	Homo sapiens	102-105
33214970-13	2020	Three individuals had Asparagine Aspartic Acid mutation at position 376 (A G), of which G6PD A(+) and G6PD A(-) were present in two and one cases, respectively.	Aspartic Acid	33-46	glucose-6-phosphate dehydrogenase	Homo sapiens	102-106
33176737-2	2020	Citrin is an aspartate-glutamate carrier located within the inner mitochondrial membrane.	Aspartic Acid	13-22	solute carrier family 25 member 13	Homo sapiens	0-6
33037124-7	2020	In addition, we identified two charged residues (aspartate-214 and lysine-223), present on opposite faces of a predicted alpha helix in the CRD, which are essential for S-acylation of Sprouty-2.	Aspartic Acid	49-58	sprouty RTK signaling antagonist 2	Rattus norvegicus	184-193
33145412-3	2020	A co-crystal structure of peptide KD2 with K-Ras(G12D) GppNHp reveals that this peptide binds in the Switch II groove region with concomitant opening of the Switch II loop and a 40  rotation of the alpha2 helix, and that a threonine residue (Thr10) on KD2 has direct access to the mutant aspartate (Asp12) on K-Ras.	Aspartic Acid	288-297	KRAS proto-oncogene, GTPase	Homo sapiens	43-48
32712387-1	2020	The proteolytic fragment ASARM (acidic serine- and aspartate-rich motif) of MEPE (matrix extracellular phosphoglycoprotein) (MEPE-ASARM) may act as an endogenous anti-mineralization factor involved in X-linked hypophosphatemic rickets/osteomalacia (XLH).	Aspartic Acid	51-60	matrix extracellular phosphoglycoprotein	Homo sapiens	76-80
32712387-1	2020	The proteolytic fragment ASARM (acidic serine- and aspartate-rich motif) of MEPE (matrix extracellular phosphoglycoprotein) (MEPE-ASARM) may act as an endogenous anti-mineralization factor involved in X-linked hypophosphatemic rickets/osteomalacia (XLH).	Aspartic Acid	51-60	matrix extracellular phosphoglycoprotein	Homo sapiens	82-122
32712387-1	2020	The proteolytic fragment ASARM (acidic serine- and aspartate-rich motif) of MEPE (matrix extracellular phosphoglycoprotein) (MEPE-ASARM) may act as an endogenous anti-mineralization factor involved in X-linked hypophosphatemic rickets/osteomalacia (XLH).	Aspartic Acid	51-60	matrix extracellular phosphoglycoprotein	Homo sapiens	125-129
33149587-0	2020	Creation of Bony Microenvironment with Extracellular Matrix Doped-Bioactive Ceramics to Enhance Osteoblast Behavior and Delivery of Aspartic Acid-Modified BMP-2 Peptides.	Aspartic Acid	132-145	bone morphogenetic protein 2	Rattus norvegicus	155-160
33052996-7	2020	The results show that the oxidative capacity of OH coordinated Cu(ii)Abeta is significantly lower than that of the free OH radical and that propagation toward Abeta Asp and His residues is favoured over Tyr residues.	Aspartic Acid	165-168	amyloid beta precursor protein	Homo sapiens	69-74
33138056-0	2020	Phospholipase A2 (PLA2) as an Early Indicator of Envenomation in Australian Elapid Snakebites (ASP-27).	Aspartic Acid	95-98	phospholipase A2 group IB	Homo sapiens	0-16
33138056-0	2020	Phospholipase A2 (PLA2) as an Early Indicator of Envenomation in Australian Elapid Snakebites (ASP-27).	Aspartic Acid	95-98	phospholipase A2 group IB	Homo sapiens	18-22
33116203-8	2020	Catalytic Asp-239 controls hMGL allosteric communications and may be considered as an essential residue for the integration and transmission of information to enzymes" remote regions, in addition to its well-known role to facilitate Ser-122 activation.	Aspartic Acid	10-13	monoglyceride lipase	Homo sapiens	27-31
33224617-10	2020	L-aspartate reduced the liver background uptake of [18F]FLT slightly.	Aspartic Acid	0-11	fms related receptor tyrosine kinase 1	Homo sapiens	56-59
33051300-4	2020	Type-A ARR proteins were degraded by autophagy in an AUTOPHAGY-RELATED (ATG)5-dependent manner, and this degradation is promoted by phosphorylation on a conserved aspartate in the receiver domain of the type-A ARRs.	Aspartic Acid	163-172	autophagy protein Apg5 family	Arabidopsis thaliana	53-77
33195271-3	2020	Solute carrier family 6 member 14 (SLC6A14), known as amino acid transporter B0,+ (ATB0,+) transports all amino acids with exception of the acidic ones: aspartate and glutamate.	Aspartic Acid	153-162	solute carrier family 6 member 14	Homo sapiens	0-33
33195271-3	2020	Solute carrier family 6 member 14 (SLC6A14), known as amino acid transporter B0,+ (ATB0,+) transports all amino acids with exception of the acidic ones: aspartate and glutamate.	Aspartic Acid	153-162	solute carrier family 6 member 14	Homo sapiens	35-42
33195271-3	2020	Solute carrier family 6 member 14 (SLC6A14), known as amino acid transporter B0,+ (ATB0,+) transports all amino acids with exception of the acidic ones: aspartate and glutamate.	Aspartic Acid	153-162	solute carrier family 6 member 14	Homo sapiens	54-79
33195271-3	2020	Solute carrier family 6 member 14 (SLC6A14), known as amino acid transporter B0,+ (ATB0,+) transports all amino acids with exception of the acidic ones: aspartate and glutamate.	Aspartic Acid	153-162	solute carrier family 1 member 5	Homo sapiens	83-87
33066323-6	2020	Our results demonstrate that the synthesized MOG peptides were formed to the deaminated products in basic conditions, and the Asn53 was mainly modified to Asp.	Aspartic Acid	155-158	myelin oligodendrocyte glycoprotein	Mus musculus	45-48
33178234-8	2020	There was evidence of 13C labeling of aspartate indicating 13CO2 fixation into oxaloacetate by PEPC and conversion to aspartate by the endogenous aspartate aminotransferase activity.	Aspartic Acid	38-47	phosphoenolpyruvate carboxylase 1	Zea mays	95-99
32817217-3	2020	We used aspartate scanning mutagenesis of Subtype B, JRFL Env as an alternate method to probe residue burial in the context of cleaved, cell surface expressed Env, as buried residues should be intolerant to substitution with Asp.	Aspartic Acid	8-17	endogenous retrovirus group K member 20	Homo sapiens	58-61
32817217-7	2020	We therefore performed sCD4 induced gp120 shedding experiments to identify Asp mutants at residues 551, 554-559, 561-567, 569 that could prevent gp120 shedding.	Aspartic Acid	75-78	stearoyl-CoA desaturase 5	Homo sapiens	23-27
32817217-7	2020	We therefore performed sCD4 induced gp120 shedding experiments to identify Asp mutants at residues 551, 554-559, 561-567, 569 that could prevent gp120 shedding.	Aspartic Acid	75-78	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	145-150
32798592-3	2020	In this study, hydroxypropyl methylcellulose (HPMC) was co-formulated at 10% (w/w) with carvedilol-L-aspartic acid (CAR-ASP) co-amorphous systems at CAR to ASP molar ratios of 1:1, 1:1.5 and 1:2.	Aspartic Acid	120-123	CXADR pseudogene 1	Homo sapiens	116-119
32798592-5	2020	HPMC was involved in the molecular interactions of the CAR-ASP-HPMC systems, but did not disturb ionic interactions between CAR and ASP.	Aspartic Acid	59-63	CXADR pseudogene 1	Homo sapiens	55-58
32798592-5	2020	HPMC was involved in the molecular interactions of the CAR-ASP-HPMC systems, but did not disturb ionic interactions between CAR and ASP.	Aspartic Acid	59-62	CXADR pseudogene 1	Homo sapiens	55-58
32812680-2	2020	A large-scale analysis of Hsp90alpha:inhibitor structures shows that inhibitor hydrogen-bonding to a conserved aspartate (D93 in Hsp90alpha) stands out as most universal among Hsp90 inhibitors.	Aspartic Acid	111-120	heat shock protein 90 alpha family class A member 1	Homo sapiens	26-36
32328881-11	2020	Indeed, mutation of valine23 to an aspartate impairs OST function in vivo resulting in a lethal phenotype in yeast.	Aspartic Acid	35-44	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	53-56
32828504-16	2020	Production of CO2 or ASP from [1-14C]C16:0 were both positively correlated (r = 0.80 and r = 0.69, respectively) with PCK1 expression.	Aspartic Acid	21-24	phosphoenolpyruvate carboxykinase 1	Bos taurus	118-122
32869445-12	2020	Catalpol inhibited the phosphorylation of TAK1 by binding to TAK1, possibly at Asp-206, Thr-208, Asn-211, Glu-297, Lys-294, and Tyr-293.	Aspartic Acid	79-82	mitogen-activated protein kinase kinase kinase 7	Mus musculus	42-46
32869445-12	2020	Catalpol inhibited the phosphorylation of TAK1 by binding to TAK1, possibly at Asp-206, Thr-208, Asn-211, Glu-297, Lys-294, and Tyr-293.	Aspartic Acid	79-82	mitogen-activated protein kinase kinase kinase 7	Mus musculus	61-65
32812680-2	2020	A large-scale analysis of Hsp90alpha:inhibitor structures shows that inhibitor hydrogen-bonding to a conserved aspartate (D93 in Hsp90alpha) stands out as most universal among Hsp90 inhibitors.	Aspartic Acid	111-120	heat shock protein 90 alpha family class A member 1	Homo sapiens	129-139
32812680-2	2020	A large-scale analysis of Hsp90alpha:inhibitor structures shows that inhibitor hydrogen-bonding to a conserved aspartate (D93 in Hsp90alpha) stands out as most universal among Hsp90 inhibitors.	Aspartic Acid	111-120	heat shock protein 90 alpha family class A member 1	Homo sapiens	26-31
32812680-8	2020	While aspartate and asparagine sidechains can both act as hydrogen bond acceptors, we show that a steric clash prevents the Hsp90 Asp93 Asn sidechain from adopting the necessary rotamer, whereas this steric restriction is absent in Topoisomerasese II.	Aspartic Acid	6-15	heat shock protein 90 alpha family class A member 1	Homo sapiens	124-129
32996003-9	2020	Role of Asp 110 in GCSF as the critical residue having adverse impact on efficacy in context of methionine oxidation has been elucidated.	Aspartic Acid	8-11	colony stimulating factor 3	Homo sapiens	19-23
32982370-5	2020	The catalytic mechanism of sPLA2 is initiated by a histidine/aspartic acid/calcium complex within the active site.	Aspartic Acid	61-74	phospholipase A2 group IIA	Homo sapiens	27-32
32914822-2	2020	The Trp-Asp-40 (WD40) domain, located in the C-terminal LRRK2, harbours one of the most frequent PD-related variants, G2385R.	Aspartic Acid	8-11	leucine rich repeat kinase 2	Homo sapiens	56-61
32822587-3	2020	The activity of PARP-1 on H2B requires NMNAT-1, a nuclear NAD+ synthase, which directs PARP-1 catalytic activity to Glu and Asp residues.	Aspartic Acid	124-127	poly (ADP-ribose) polymerase family, member 1	Mus musculus	16-22
32822587-3	2020	The activity of PARP-1 on H2B requires NMNAT-1, a nuclear NAD+ synthase, which directs PARP-1 catalytic activity to Glu and Asp residues.	Aspartic Acid	124-127	nicotinamide nucleotide adenylyltransferase 1	Mus musculus	39-46
32822587-3	2020	The activity of PARP-1 on H2B requires NMNAT-1, a nuclear NAD+ synthase, which directs PARP-1 catalytic activity to Glu and Asp residues.	Aspartic Acid	124-127	poly (ADP-ribose) polymerase family, member 1	Mus musculus	87-93
33054131-6	2021	Red blood cells express an L-Isoaspartyl methyltransferase (PIMT, gene name PCMT1) that can convert succinimidyl groups back to an aspartate.	Aspartic Acid	131-140	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	60-64
32932964-5	2020	The substitution of endogenous OCT4 by a mimic of phosphorylated OCT4 with a serine-to-aspartate mutation at S236 (S236D) resulted in tumor cell differentiation, growth retardation, and inhibition of tumor sphere formation.	Aspartic Acid	87-96	POU class 5 homeobox 1	Homo sapiens	31-35
32828303-6	2020	Arf4-HA-GFP could be partially reverted to the behavior of Arf4-GFP by mutation of two aspartic acids in the HA tag to alanine.	Aspartic Acid	87-101	ADP ribosylation factor 4	Homo sapiens	0-4
32828303-6	2020	Arf4-HA-GFP could be partially reverted to the behavior of Arf4-GFP by mutation of two aspartic acids in the HA tag to alanine.	Aspartic Acid	87-101	ADP ribosylation factor 4	Homo sapiens	59-63
33054131-6	2021	Red blood cells express an L-Isoaspartyl methyltransferase (PIMT, gene name PCMT1) that can convert succinimidyl groups back to an aspartate.	Aspartic Acid	131-140	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	76-81
32819565-6	2020	l-Lactate uptake assay and site-directed mutagenesis revealed that the aspartic acid of hMCT1 (hMCT1 D414) was an important residue conserved in MCT1, 2, and 4 (hMCT2 D398 and hMCT4 D379).	Aspartic Acid	71-84	solute carrier family 16 member 1	Homo sapiens	88-93
32819565-6	2020	l-Lactate uptake assay and site-directed mutagenesis revealed that the aspartic acid of hMCT1 (hMCT1 D414) was an important residue conserved in MCT1, 2, and 4 (hMCT2 D398 and hMCT4 D379).	Aspartic Acid	71-84	solute carrier family 16 member 1	Homo sapiens	145-159
32819565-0	2020	Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.	Aspartic Acid	46-60	solute carrier family 16 member 1	Homo sapiens	80-120
32819565-6	2020	l-Lactate uptake assay and site-directed mutagenesis revealed that the aspartic acid of hMCT1 (hMCT1 D414) was an important residue conserved in MCT1, 2, and 4 (hMCT2 D398 and hMCT4 D379).	Aspartic Acid	71-84	solute carrier family 16 member 7	Homo sapiens	161-166
32819565-9	2020	Finally, we investigated the conserved aspartic acids of hMCT2 and 4, and revealed that these residues were essential for l-lactate transport.	Aspartic Acid	39-53	solute carrier family 16 member 7	Homo sapiens	57-68
32819565-10	2020	These findings suggested that the extracellular aspartic acids conserved in hMCT1, 2, and 4 played important roles in transport activity and pH dependency, and can function as a first step of substrate and H+ recognition and transport from the extracellular to the intracellular region.	Aspartic Acid	48-62	solute carrier family 16 member 1	Homo sapiens	76-91
32768957-6	2020	Furthermore, using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), we clarified that NG-R1 regulated ATP metabolism, the tricarboxylic acid (TCA) cycle, the malate-aspartate shuttle, antioxidant activity, and the homeostasis of iron and phospholipids in the striatum and hippocampus of middle cerebral artery occlusion/reperfusion (MCAO/R) rats.	Aspartic Acid	199-208	reticulon 4 receptor	Rattus norvegicus	120-125
32533225-9	2020	The AOx/P(L-Asp)/ND-CNF/GCE biosensor was successfully applied to the determination of L-ascorbic acid in vitamin C effervescent tablet and pharmaceutical powder containing ascorbic acid with good results, which makes it a promising approach for quantification of L-ascorbic acid.	Aspartic Acid	10-15	acyl-CoA oxidase 1	Homo sapiens	4-7
32576658-5	2020	The catalytic domain displayed a polypeptide fold similar overall to those of other members in the DNA cross-link repair gene SNM1 family and in mRNA 3"-end-processing endonuclease CPSF-73, containing metallo-beta-lactamase and beta-CASP domains and a cluster of conserved histidine and aspartate residues capable of binding two metal atoms in the catalytic site.	Aspartic Acid	287-296	DNA cross-link repair 1A	Homo sapiens	126-130
32769062-0	2020	Optimization and validation of a chiral CE-LIF method for quantitation of aspartate, glutamate and serine in murine osteocytic and osteoblastic cells.	Aspartic Acid	74-83	leukemia inhibitory factor	Mus musculus	43-46
32601484-3	2020	We have identified the highly unusual alpha/beta-hydrolase (ABH) fold enzyme BotH as a peptide epimerase responsible for the post-translational epimerization of L-Asp to D-Asp during bottromycin biosynthesis.	Aspartic Acid	161-166	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	60-63
32651261-3	2020	Exhaustion of aspartate in these cells resulted in immediate depletion of adenylates, which plays a central role in mediating mTOR inactivation and inhibition of glycolysis.	Aspartic Acid	14-23	mechanistic target of rapamycin kinase	Mus musculus	126-130
32651261-7	2020	SIGNIFICANCE: These findings demonstrate that OXPHOS deficiency caused by either hypoxia or mutations, which can significantly increase cancer virulence, renders tumors sensitive to aKG esters by targeting their dependence upon GOT1 for aspartate synthesis.	Aspartic Acid	237-246	glutamic-oxaloacetic transaminase 1, soluble	Mus musculus	228-232
32697413-5	2020	Herein, we identify the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a critical intrinsic negative regulator of inflammation, which broadly attenuates pro-inflammatory gene programs in macrophages.	Aspartic Acid	79-92	CREB binding protein	Homo sapiens	24-28
32697413-5	2020	Herein, we identify the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a critical intrinsic negative regulator of inflammation, which broadly attenuates pro-inflammatory gene programs in macrophages.	Aspartic Acid	79-92	E1A binding protein p300	Homo sapiens	28-32
32697413-5	2020	Herein, we identify the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a critical intrinsic negative regulator of inflammation, which broadly attenuates pro-inflammatory gene programs in macrophages.	Aspartic Acid	79-92	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	126-132
32872412-3	2020	The Arg-90 and Glu-98 from MotA interact with Asp-289 and Arg-281 of FliG, respectively.	Aspartic Acid	46-49	FRAS1 related extracellular matrix 1	Homo sapiens	27-31
32576658-5	2020	The catalytic domain displayed a polypeptide fold similar overall to those of other members in the DNA cross-link repair gene SNM1 family and in mRNA 3"-end-processing endonuclease CPSF-73, containing metallo-beta-lactamase and beta-CASP domains and a cluster of conserved histidine and aspartate residues capable of binding two metal atoms in the catalytic site.	Aspartic Acid	287-296	cleavage and polyadenylation specificity factor 3	Mus musculus	145-188
32833997-10	2020	In contrast, Cryab-R120G knock-in lenses exhibited increased total amino acid content including valine, alanine, serine, leucine, isoleucine, glycine, and aspartic acid.	Aspartic Acid	155-168	crystallin, alpha B	Mus musculus	13-18
32807064-7	2021	Docking studies indicated favorable interactions of the di-substituted peptide coumarin derivatives with the Asp 351 and Thr 347 amino acids at the active site of human estrogen receptor.	Aspartic Acid	109-112	estrogen receptor 1	Homo sapiens	169-186
32599125-5	2020	Incubation with hypertonic solution also decreases the immunoreactivity to the membrane glutamate/aspartate transporter (GLAST) as well as tritiated-aspartate uptake by astrocytes.	Aspartic Acid	98-107	solute carrier family 1 member 3	Homo sapiens	121-126
32821686-9	2020	The gross deletion lead to a frame-shift mutation and generate stop codon at 7 animo acid behind Asp (D10Afs*7), which would serious truncate RPGR protein.	Aspartic Acid	97-100	retinitis pigmentosa GTPase regulator	Homo sapiens	142-146
32571877-4	2020	PAICS catalyzes the carboxylation of aminoimidazole ribonucleotide (AIR) and the subsequent conversion of carboxyaminoimidazole ribonucleotide (CAIR) and L-aspartate to N-succinylcarboxamide-5-aminoimidazole ribonucleotide (SAICAR).	Aspartic Acid	154-165	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Homo sapiens	0-5
32422489-9	2020	Molecular docking studies also shown that compound 12k capably intermingled with catalytically active residues GLU-885, ASP-1046 of the VEGFR-2 through hydrogen-bonding interactions.	Aspartic Acid	120-123	kinase insert domain receptor	Homo sapiens	136-143
32463099-2	2020	Aspartic acid 383 (D383) in MEIOB is critical for its interaction with SPATA22 in biochemical studies.	Aspartic Acid	0-13	meiosis specific with OB domains	Mus musculus	28-33
32818073-5	2020	Excitatory amino acid carrier 1 (EAAC1) is an excitatory amino acid transporter expressed specifically by neurons and is the route for the neuronal uptake of glutamate/aspartate/cysteine.	Aspartic Acid	168-177	solute carrier family 1 member 1	Rattus norvegicus	0-31
32818073-5	2020	Excitatory amino acid carrier 1 (EAAC1) is an excitatory amino acid transporter expressed specifically by neurons and is the route for the neuronal uptake of glutamate/aspartate/cysteine.	Aspartic Acid	168-177	solute carrier family 1 member 1	Rattus norvegicus	33-38
32639720-1	2020	We report the results of computational modeling of a three-dimensional all-atom structure of the membrane-associated protein encoded by the NAT8L gene, aspartate N-acetyltransferase, which is essential for brain synthesis of N-acetyl-L-aspartate (NAA).	Aspartic Acid	152-161	N-acetyltransferase 8 like	Homo sapiens	140-145
32639720-3	2020	We apply a computational protocol employing the contact map prediction, ab initio folding, homology modeling and refinement to obtain a structure of NAT8L with the aspartate and acetyl coenzyme A cofactors in the protein molecule.	Aspartic Acid	164-173	N-acetyltransferase 8 like	Homo sapiens	149-154
32463099-2	2020	Aspartic acid 383 (D383) in MEIOB is critical for its interaction with SPATA22 in biochemical studies.	Aspartic Acid	0-13	spermatogenesis associated 22	Mus musculus	71-78
32363662-4	2020	To gain insight into a plausible effect of BPA exposure in the liver glutamate/aspartate transport, using the human hepatoblastoma cell line HepG2, we report a BPA-dependent dynamic regulation of SLC1A3 and SLC1A2.	Aspartic Acid	79-88	solute carrier family 1 member 3	Homo sapiens	196-202
32363662-4	2020	To gain insight into a plausible effect of BPA exposure in the liver glutamate/aspartate transport, using the human hepatoblastoma cell line HepG2, we report a BPA-dependent dynamic regulation of SLC1A3 and SLC1A2.	Aspartic Acid	79-88	solute carrier family 1 member 2	Homo sapiens	207-213
32374903-2	2020	The major mutation detected to date in the SARS-CoV-2 viral envelope spike protein, which is responsible for virus attachment to the host and is also the main target for host antibodies, is a mutation of an aspartate (D) at position 614 found frequently in Chinese strains to a glycine (G).	Aspartic Acid	207-216	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	69-74
32722104-4	2020	AGC2 (aspartate glutamate carrier 2) or citrin is a mitochondrial transporter which transports aspartate (Asp) from mitochondria to cytosol in exchange with glutamate (Glu) and H+.	Aspartic Acid	6-15	solute carrier family 25 member 13	Homo sapiens	40-46
32627111-5	2020	Acquired differences in amino acid content of different types of random coils, alpha helices, and beta strands led to the formation of partially buried but hydrophilic BCH random coils because of their enrichment by Ser, Thr, and Asp residues.	Aspartic Acid	230-233	chimerin 2	Homo sapiens	168-171
32396938-0	2020	MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells.	Aspartic Acid	21-30	malate dehydrogenase 1, NAD (soluble)	Mus musculus	0-4
32396938-6	2020	Mechanistically, STAT3 transactivates MDH1 to sustain the malate-aspartate NADH shuttle activity and the HSC self-renewal and differentiation.	Aspartic Acid	65-74	signal transducer and activator of transcription 3	Mus musculus	17-22
32396938-6	2020	Mechanistically, STAT3 transactivates MDH1 to sustain the malate-aspartate NADH shuttle activity and the HSC self-renewal and differentiation.	Aspartic Acid	65-74	malate dehydrogenase 1, NAD (soluble)	Mus musculus	38-42
32831963-9	2020	In EGFR-mt group, all the image parameters of SUVmax, MTV, TLG, and ASP were significantly lower than in EGFR-wt group (all adjusted P < 0.050).	Aspartic Acid	68-71	epidermal growth factor receptor	Homo sapiens	3-7
32831963-10	2020	In univariable logistic regression, SUVmax (P = 0.003) and ASP (P = 0.010) were significant determinants for EGFR-mt, whereas MTV was not (P = 0.690).	Aspartic Acid	59-62	epidermal growth factor receptor	Homo sapiens	109-113
32831963-11	2020	Multivariate analysis revealed that SUVmax and ASP are independent determinants for EGFR-mt, regardless of inclusion of MTV in the analysis (P < 0.05).	Aspartic Acid	47-50	epidermal growth factor receptor	Homo sapiens	84-88
32831963-12	2020	Conclusion: In Asian NSCLC/ADC patients, SUVmax, MTV, and ASP on FDG PET are significantly related to EGFR mutation status.	Aspartic Acid	58-61	epidermal growth factor receptor	Homo sapiens	102-106
32831963-13	2020	Particularly, low SUVmax and ASP are independent determinants for EGFR-mt.	Aspartic Acid	29-32	epidermal growth factor receptor	Homo sapiens	66-70
32850889-9	2020	However, the patient experienced an elevation of Alanine aminotransferase (ALT) and Aspartate aminotransmerase (AST), which was diagnosed as the immune-related hepatitis.	Aspartic Acid	84-93	solute carrier family 17 member 5	Homo sapiens	112-115
32722104-4	2020	AGC2 (aspartate glutamate carrier 2) or citrin is a mitochondrial transporter which transports aspartate (Asp) from mitochondria to cytosol in exchange with glutamate (Glu) and H+.	Aspartic Acid	106-109	solute carrier family 25 member 13	Homo sapiens	40-46
32722104-9	2020	It is forced under citrin deficiency since citrin is a member of malate/Asp shuttle.	Aspartic Acid	72-75	solute carrier family 25 member 13	Homo sapiens	19-25
32722104-9	2020	It is forced under citrin deficiency since citrin is a member of malate/Asp shuttle.	Aspartic Acid	72-75	solute carrier family 25 member 13	Homo sapiens	43-49
32707027-1	2021	L-Asparaginase is an important enzyme which converts L-asparagine to L-aspartate and ammonia.	Aspartic Acid	69-80	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
32708212-4	2020	A specific regulation of ASP+ transport by hMATE1 and hMATE2K measured in uptake and efflux configurations was observed.	Aspartic Acid	25-28	solute carrier family 47 member 1	Homo sapiens	43-49
31600783-8	2020	We identify a pH-sensitive electrostatic interaction between positively charged arginine in extracellular loop 2 (K210) and a negatively charged aspartate (D112) in extracellular loop 1 that helps determine Orai1 turnover.	Aspartic Acid	145-154	ORAI calcium release-activated calcium modulator 1	Homo sapiens	207-212
32708212-4	2020	A specific regulation of ASP+ transport by hMATE1 and hMATE2K measured in uptake and efflux configurations was observed.	Aspartic Acid	25-28	solute carrier family 47 member 2	Homo sapiens	54-61
32708212-5	2020	In the example of hMATE1 efflux reduction by inhibition of casein kinase II, it was also shown that this regulation is able to modify transcellular transport of ASP+ in Madin-Darby canine kidney II cells expressing hOCT2 and hMATE1 on the basolateral and apical membrane domains, respectively.	Aspartic Acid	161-165	solute carrier family 47 member 1	Homo sapiens	18-24
32708212-5	2020	In the example of hMATE1 efflux reduction by inhibition of casein kinase II, it was also shown that this regulation is able to modify transcellular transport of ASP+ in Madin-Darby canine kidney II cells expressing hOCT2 and hMATE1 on the basolateral and apical membrane domains, respectively.	Aspartic Acid	161-165	POU class 2 homeobox 2	Homo sapiens	215-220
32616567-8	2020	The frequent incidence of Asp residues in the cleavage region of Rcr3-like proteases in solanaceous plants indicates that activation of immune proteases by SBTs is a general mechanism, illuminating a proteolytic cascade that provides robust apoplastic immunity.	Aspartic Acid	26-29	cysteine protease	Solanum lycopersicum	65-69
32708212-5	2020	In the example of hMATE1 efflux reduction by inhibition of casein kinase II, it was also shown that this regulation is able to modify transcellular transport of ASP+ in Madin-Darby canine kidney II cells expressing hOCT2 and hMATE1 on the basolateral and apical membrane domains, respectively.	Aspartic Acid	161-165	solute carrier family 47 member 1	Homo sapiens	225-231
32708308-3	2020	Here, we report that these two bioactive tripeptides, phenylalanine-lysine-aspartic acid and phenylalanine-lysine-glutamic acid (FKD and FKE, respectively), inhibit ERK and cJun activation following human macrophage exposure to LPS.	Aspartic Acid	75-88	mitogen-activated protein kinase 1	Homo sapiens	165-168
32708308-3	2020	Here, we report that these two bioactive tripeptides, phenylalanine-lysine-aspartic acid and phenylalanine-lysine-glutamic acid (FKD and FKE, respectively), inhibit ERK and cJun activation following human macrophage exposure to LPS.	Aspartic Acid	75-88	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	173-177
32335227-6	2020	The structural changes of NS3 are mediated by conserved residues and reveal a subpocket, which we denote as subpocket B, extending beyond the catalytic aspartate 75 towards an allosteric binding site, providing a unique connection between the orthosteric and allosteric sites in the protease.	Aspartic Acid	152-161	KRAS proto-oncogene, GTPase	Homo sapiens	26-29
32345439-7	2020	Furthermore, the analysis of alpha-crystallin extracted from bovine eye lens identified isomerized Asp residues (Asp24/35, Asp58, and Asp151 in AAC and Asp140 in alphaB-crystallin (ABC)).	Aspartic Acid	99-102	crystallin alpha B	Bos taurus	162-179
32733999-6	2020	Examination of the GADL1 active site indicated that the enzyme may have multiple physiological substrates, including aspartate and cysteine sulfinic acid.	Aspartic Acid	117-126	glutamate decarboxylase-like 1	Mus musculus	19-24
32479628-3	2020	Here, we found that a nucleolar factor called nucleolar protein 11 (NOL11) forms a protein complex with two tryptophan-aspartic acid (WD) repeat proteins named WD-repeat protein 43 (WDR43) and Cirhin in mitotic cells.	Aspartic Acid	119-132	nucleolar protein 11	Homo sapiens	46-66
32479628-3	2020	Here, we found that a nucleolar factor called nucleolar protein 11 (NOL11) forms a protein complex with two tryptophan-aspartic acid (WD) repeat proteins named WD-repeat protein 43 (WDR43) and Cirhin in mitotic cells.	Aspartic Acid	119-132	nucleolar protein 11	Homo sapiens	68-73
32479628-3	2020	Here, we found that a nucleolar factor called nucleolar protein 11 (NOL11) forms a protein complex with two tryptophan-aspartic acid (WD) repeat proteins named WD-repeat protein 43 (WDR43) and Cirhin in mitotic cells.	Aspartic Acid	119-132	WD repeat domain 43	Homo sapiens	160-180
32479628-3	2020	Here, we found that a nucleolar factor called nucleolar protein 11 (NOL11) forms a protein complex with two tryptophan-aspartic acid (WD) repeat proteins named WD-repeat protein 43 (WDR43) and Cirhin in mitotic cells.	Aspartic Acid	119-132	WD repeat domain 43	Homo sapiens	182-187
32479628-3	2020	Here, we found that a nucleolar factor called nucleolar protein 11 (NOL11) forms a protein complex with two tryptophan-aspartic acid (WD) repeat proteins named WD-repeat protein 43 (WDR43) and Cirhin in mitotic cells.	Aspartic Acid	119-132	UTP4 small subunit processome component	Homo sapiens	193-199
32715208-11	2020	In addition, these observations were in all cases associated with key intermolecular interactions with neighboring residues, such as tyrosine and aspartic acid, in the binding of the ligands to the monoamine transporter for dopamine.	Aspartic Acid	146-159	solute carrier family 18 member A2	Homo sapiens	198-219
32349075-10	2020	CONCLUSIONS: These findings indicate that estrogen receptor-beta and G protein-coupled estrogen receptor-1 but not estrogen receptor-alpha in the rostral anterior cingulate cortex contribute to pain-related aversion by modulating N-methyl-D-aspartate receptor-mediated excitatory synaptic transmission.	Aspartic Acid	241-250	estrogen receptor 1 (alpha)	Mus musculus	42-64
32349075-10	2020	CONCLUSIONS: These findings indicate that estrogen receptor-beta and G protein-coupled estrogen receptor-1 but not estrogen receptor-alpha in the rostral anterior cingulate cortex contribute to pain-related aversion by modulating N-methyl-D-aspartate receptor-mediated excitatory synaptic transmission.	Aspartic Acid	241-250	G protein-coupled estrogen receptor 1	Mus musculus	69-106
32251994-2	2020	To achieve this, molecular dynamics (MD) simulation of RNase A and alpha-lactalbumin was performed in the presence of three charged amino acids Arg, Lys, and Asp and the molecular mechanism of amino acid-induced (de)stabilization of the proteins was examined by combining with our earlier report on Glu.	Aspartic Acid	158-161	ribonuclease A family member 1, pancreatic	Homo sapiens	55-62
32446448-6	2020	A single amino acid residue difference in oligopeptides can make the reaction rate constants differ by over 60% (e.g. 3.01 x 104 (mol/L)-1sec-1 for DDDWNDD and 1.85 x 104 (mol/L)-1sec-1 for DDDWDDD at pH 7.0 (D: aspartic acid, W: tryptophan, N: asparagine)).	Aspartic Acid	212-225	secretory blood group 1, pseudogene	Homo sapiens	138-143
32251994-2	2020	To achieve this, molecular dynamics (MD) simulation of RNase A and alpha-lactalbumin was performed in the presence of three charged amino acids Arg, Lys, and Asp and the molecular mechanism of amino acid-induced (de)stabilization of the proteins was examined by combining with our earlier report on Glu.	Aspartic Acid	158-161	lactalbumin alpha	Homo sapiens	67-84
32803110-0	2020	FAM20C-Mediated Phosphorylation of MEPE and Its Acidic Serine- and Aspartate-Rich Motif.	Aspartic Acid	67-76	FAM20C golgi associated secretory pathway kinase	Homo sapiens	0-6
32452419-0	2020	Aspartic acid at residue 185 modulates the capacity of HP-PRRSV nsp4 to antagonize IFN-I expression.	Aspartic Acid	0-13	serine protease 57	Homo sapiens	64-68
32452419-2	2020	Here, we demonstrated that the mutation of Aspartic acid 185 (Asp185) impaired the ability of nsp4 to inhibit IFN-I production induced by poly(I:C).	Aspartic Acid	43-56	serine protease 57	Homo sapiens	94-98
32541034-4	2020	We report here the discovery of ergosteryl-3beta-O-l-aspartate (Erg-Asp), a conjugated sterol that is produced by the tRNA-dependent addition of aspartate to the 3beta-OH group of ergosterol, the major sterol found in fungal membranes.	Aspartic Acid	53-62	ETS transcription factor ERG	Homo sapiens	64-67
32541034-7	2020	We also uncovered that removal of the Asp modifier from Erg-Asp is catalyzed by a second enzyme, ErdH, that is a genuine Erg-Asp hydrolase participating in the turnover of the conjugated sterol in vivo.	Aspartic Acid	38-41	ETS transcription factor ERG	Homo sapiens	56-59
32541034-7	2020	We also uncovered that removal of the Asp modifier from Erg-Asp is catalyzed by a second enzyme, ErdH, that is a genuine Erg-Asp hydrolase participating in the turnover of the conjugated sterol in vivo.	Aspartic Acid	38-41	ETS transcription factor ERG	Homo sapiens	121-124
32541034-8	2020	Phylogenomics highlights that the entire Erg-Asp synthesis/degradation pathway is conserved across "higher" fungi.	Aspartic Acid	45-48	ETS transcription factor ERG	Homo sapiens	41-44
32532115-2	2020	In this work, we utilized mass spectrometry-based lipidomic approaches to investigate the action of Asp-49 Ca2+-dependent secreted phospholipase A2 (sPLA2) (MT-III) and Lys-49 sPLA2 (MT-II), two group IIA phospholipase A2s isolated from the venom of the snake Bothrops asper, on human peripheral blood monocytes.	Aspartic Acid	100-103	metallothionein 2A	Homo sapiens	157-162
32515459-6	2020	These three peptides showed hydrophobic and acidic amino acid residues (Asp and Glu) and/or their amines (Asn and Gln), which could be a common feature among lipid-lowering peptides related to CE and PL enzyme inhibition.	Aspartic Acid	72-75	pancreatic lipase	Homo sapiens	200-202
32571324-2	2020	The present study aims to investigate whether mitochondrial apoptosis in aplastic anemia could be corrected by ASP by adjusting an abnormal level of regulatory T cell (Treg)/ IL-17 secreting CD4 T cell (Th17) ratio.	Aspartic Acid	111-114	CD4 antigen	Mus musculus	191-194
32571324-7	2020	RESULTS: The mice treated with the medium dose of ASP for 14 days showed increased white blood cell (WBC), red blood cell (RBC), platelet (PLT), BMNC counts and Lin-Sca-1 + c-Kit+ (LSK) populations viability compared with the mice in the AA group mice.	Aspartic Acid	50-53	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	173-178
32571324-7	2020	RESULTS: The mice treated with the medium dose of ASP for 14 days showed increased white blood cell (WBC), red blood cell (RBC), platelet (PLT), BMNC counts and Lin-Sca-1 + c-Kit+ (LSK) populations viability compared with the mice in the AA group mice.	Aspartic Acid	50-53	lymphocyte protein tyrosine kinase	Mus musculus	181-184
32571324-8	2020	The data showed that ASP decreased damage to the mitochondrial outer membrane, improved the stabilization of the mitochondrial membrane, and corrected the abnormal levels of ROS and mitochondrial-associated apoptosis proteins, including the Bcl-2/Bax ratio and caspase-3 and caspase-9 expression, in BMNCs which were sorted from the bone marrow cells of AA mice.	Aspartic Acid	21-24	B cell leukemia/lymphoma 2	Mus musculus	241-246
32571324-8	2020	The data showed that ASP decreased damage to the mitochondrial outer membrane, improved the stabilization of the mitochondrial membrane, and corrected the abnormal levels of ROS and mitochondrial-associated apoptosis proteins, including the Bcl-2/Bax ratio and caspase-3 and caspase-9 expression, in BMNCs which were sorted from the bone marrow cells of AA mice.	Aspartic Acid	21-24	BCL2-associated X protein	Mus musculus	247-250
32571324-8	2020	The data showed that ASP decreased damage to the mitochondrial outer membrane, improved the stabilization of the mitochondrial membrane, and corrected the abnormal levels of ROS and mitochondrial-associated apoptosis proteins, including the Bcl-2/Bax ratio and caspase-3 and caspase-9 expression, in BMNCs which were sorted from the bone marrow cells of AA mice.	Aspartic Acid	21-24	caspase 3	Mus musculus	261-270
32571324-8	2020	The data showed that ASP decreased damage to the mitochondrial outer membrane, improved the stabilization of the mitochondrial membrane, and corrected the abnormal levels of ROS and mitochondrial-associated apoptosis proteins, including the Bcl-2/Bax ratio and caspase-3 and caspase-9 expression, in BMNCs which were sorted from the bone marrow cells of AA mice.	Aspartic Acid	21-24	caspase 9	Mus musculus	275-284
32571324-9	2020	The changes to the p-P38/P38 and Treg/Th17 ratios induced by AA were also reversed by the medium dose of ASP.	Aspartic Acid	105-108	mitogen-activated protein kinase 14	Mus musculus	21-24
32571324-9	2020	The changes to the p-P38/P38 and Treg/Th17 ratios induced by AA were also reversed by the medium dose of ASP.	Aspartic Acid	105-108	mitogen-activated protein kinase 14	Mus musculus	25-28
32688289-1	2020	PURPOSE: Integrin alphavbeta3, a member of the arginine-glycine-aspartate (RGD)-binding subfamily, is associated with tumor angiogenesis and metastasis.	Aspartic Acid	64-73	integrin subunit alpha V	Homo sapiens	9-29
32555317-3	2020	SLC25A11, a member of the malate-aspartate shuttle (MAS), regulates electroneutral exchange between 2-oxoglutarate and other dicarboxylates.	Aspartic Acid	33-42	solute carrier family 25 member 11	Homo sapiens	0-8
32545833-1	2020	N-acetylaspartate is produced by neuronal aspartate N-acetyltransferase (NAT8L) from acetyl-CoA and aspartate.	Aspartic Acid	8-17	N-acetyltransferase 8-like	Rattus norvegicus	73-78
32545833-1	2020	N-acetylaspartate is produced by neuronal aspartate N-acetyltransferase (NAT8L) from acetyl-CoA and aspartate.	Aspartic Acid	42-51	N-acetyltransferase 8-like	Rattus norvegicus	73-78
32350117-7	2020	Site-specific replacement of active-site amino acids revealed the presence of a water-coordinating aspartate residue that limits esterase activity.	Aspartic Acid	99-108	AT695_RS05650	Staphylococcus aureus	129-137
32420742-4	2020	We did not observe any complete Ca2+ leak event, but we identified four persistent Ca2+ sites in membrane-bound PS1 and PS2: One in HL2 near the C-terminal of TM6, one in HL2 towards the N-terminal of TM7, a site at the catalytic aspartate on TM7, and a site at the PALP motif on TM9.	Aspartic Acid	230-239	presenilin 1	Homo sapiens	112-115
32556284-3	2020	The patient had a homozygous substitution of glycine by aspartate at amino acid residue 412 (Gly412Asp) in the thrombin-binding domain of the thrombomodulin gene (designated thrombomodulin-Nagasaki).	Aspartic Acid	56-65	coagulation factor II, thrombin	Homo sapiens	111-119
32556284-3	2020	The patient had a homozygous substitution of glycine by aspartate at amino acid residue 412 (Gly412Asp) in the thrombin-binding domain of the thrombomodulin gene (designated thrombomodulin-Nagasaki).	Aspartic Acid	56-65	thrombomodulin	Homo sapiens	142-156
32556284-3	2020	The patient had a homozygous substitution of glycine by aspartate at amino acid residue 412 (Gly412Asp) in the thrombin-binding domain of the thrombomodulin gene (designated thrombomodulin-Nagasaki).	Aspartic Acid	56-65	thrombomodulin	Homo sapiens	174-188
32587973-2	2020	We therefore compared the functional properties of the S proteins with aspartic acid (S D614 ) and glycine (S G614 ) at residue 614.	Aspartic Acid	71-84	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	55-56
32119754-6	2020	Molecular validation of MitoFlag shows that adding NLS, replacing aspartic acid residues by glutamic acid residues, or changing L-aspartic acid to D-aspartic residue abolishes the trafficking of H2B into mitochondria of HeLa cells.	Aspartic Acid	128-143	H2B clustered histone 21	Homo sapiens	195-198
32499446-5	2020	Reduced circ-SEC31A expression in NSCLC decreased tumor cell proliferation, migration, invasion, and malate-aspartate metabolism.	Aspartic Acid	108-117	SEC31 homolog A, COPII coat complex component	Homo sapiens	13-19
32499446-6	2020	Mechanistically, we demonstrated that silencing circ-SEC31A downregulated GOT-2 expression by relieving the sponging effect of miR-520a-5p, which resulted in significantly reduced malate-aspartate metabolism in NSCLC cells.	Aspartic Acid	187-196	SEC31 homolog A, COPII coat complex component	Homo sapiens	53-59
32499446-6	2020	Mechanistically, we demonstrated that silencing circ-SEC31A downregulated GOT-2 expression by relieving the sponging effect of miR-520a-5p, which resulted in significantly reduced malate-aspartate metabolism in NSCLC cells.	Aspartic Acid	187-196	glutamic-oxaloacetic transaminase 2	Homo sapiens	74-79
32499446-6	2020	Mechanistically, we demonstrated that silencing circ-SEC31A downregulated GOT-2 expression by relieving the sponging effect of miR-520a-5p, which resulted in significantly reduced malate-aspartate metabolism in NSCLC cells.	Aspartic Acid	187-196	microRNA 520a	Homo sapiens	127-135
32413313-7	2020	Whereas mutation of a key active-site aspartic acid residue prevents OAS2 activity, a C-terminal mutation previously hypothesized to disrupt OAS self-association had only a minor effect on OAS2 activity.	Aspartic Acid	38-51	2'-5'-oligoadenylate synthetase 2	Homo sapiens	69-73
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Aspartic Acid	133-136	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Aspartic Acid	133-136	vitronectin	Homo sapiens	269-278
32413313-7	2020	Whereas mutation of a key active-site aspartic acid residue prevents OAS2 activity, a C-terminal mutation previously hypothesized to disrupt OAS self-association had only a minor effect on OAS2 activity.	Aspartic Acid	38-51	SPARC related modular calcium binding 1	Homo sapiens	69-72
31785178-6	2020	Our spectroscopic and mutagenesis studies further identified a set of conserved aspartate residues in the dehydrogenase domain that are essential for NOX5 activation.	Aspartic Acid	80-89	NADPH oxidase 5	Homo sapiens	150-154
32542191-8	2020	On d 21 post-weaning, compared to control group, Glu, Gln and Asp supplementation up-regulated the mRNA levels of ACOX1, ME1 and SIRT1 (P < 0.05).	Aspartic Acid	62-65	acyl-CoA oxidase 1	Homo sapiens	114-119
32542191-8	2020	On d 21 post-weaning, compared to control group, Glu, Gln and Asp supplementation up-regulated the mRNA levels of ACOX1, ME1 and SIRT1 (P < 0.05).	Aspartic Acid	62-65	malic enzyme 1	Homo sapiens	121-124
32542191-8	2020	On d 21 post-weaning, compared to control group, Glu, Gln and Asp supplementation up-regulated the mRNA levels of ACOX1, ME1 and SIRT1 (P < 0.05).	Aspartic Acid	62-65	sirtuin 1	Homo sapiens	129-134
32598580-5	2020	We used arginine-glycine-aspartic acid-poly (ethylene glycol)-polyethyleneimine (RGD-PEG-PEI) for the specific transfer of SHP into hepatic stellate cells (HSC).	Aspartic Acid	25-38	nuclear receptor subfamily 0, group B, member 2	Rattus norvegicus	123-126
32217372-7	2020	The peptides 1-3 containing Glu-Urea-Lys and Glu-GABA-Asp as pharmacophores were efficiently interacted with crystal structure of PSMA and showed the highest binding energies range from -8 to -11.2 kcal/mol.	Aspartic Acid	54-57	folate hydrolase 1	Homo sapiens	130-134
32335094-1	2020	AIMS: Citrin is an aspartate/glutamate carrier that composes the malate-aspartate reduced nicotinamide adenine dinucleotide (NADH) shuttle in the liver.	Aspartic Acid	19-28	solute carrier family 25 member 13	Homo sapiens	6-12
32335094-1	2020	AIMS: Citrin is an aspartate/glutamate carrier that composes the malate-aspartate reduced nicotinamide adenine dinucleotide (NADH) shuttle in the liver.	Aspartic Acid	72-81	solute carrier family 25 member 13	Homo sapiens	6-12
32485878-7	2020	In particular, Gemin5 is a multidomain protein that comprises tryptophan-aspartic acid (WD) repeat motifs at the N-terminal region, a dimerization domain at the middle region, and a non-canonical RNA-binding domain at the C-terminal end of the protein.	Aspartic Acid	73-86	gem nuclear organelle associated protein 5	Homo sapiens	15-21
32395991-0	2020	Post-Synthetic Functionalization of Ni-MOF by Eu3+ Ions: Luminescent Probe for Aspartic Acid and Magnetic Property.	Aspartic Acid	79-92	lysine acetyltransferase 8	Homo sapiens	39-42
32390192-5	2020	Unexpectedly, Arg84 from SPPV14 forms an ionic interaction with the conserved Asp in the BH3 motif in a manner that replaces the canonical ionic interaction seen in almost all host Bcl-2:BH3 motif complexes.	Aspartic Acid	78-81	BCL2 apoptosis regulator	Homo sapiens	181-186
32144526-0	2020	Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus.	Aspartic Acid	65-74	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	24-29
32479549-5	2020	Our results indicate that the invariant aspartate of the J-domain perturbs a conserved intramolecular Hsp70 network of contacts that crosses domains.	Aspartic Acid	40-49	heat shock protein family A (Hsp70) member 4	Homo sapiens	102-107
31908106-4	2020	Genetic analysis identified a de novo non-sense variant affecting the aspartate dehydrogenase domain containing (ASPDH) gene, which might be associated with the formation of subepidermal vesicles in this case.	Aspartic Acid	70-79	ASPDH	Bos taurus	113-118
32280065-3	2020	Compared with WT mice, mice lacking DEL-1 or expressing a DEL-1 variant with an Asp-to-Glu substitution in the RGD motif ("RGE point mutant"), which does not interact with RGD-dependent integrins, exhibited defective bone regeneration.	Aspartic Acid	80-83	EGF-like repeats and discoidin I-like domains 3	Mus musculus	58-63
32265297-5	2020	The OTUB1 protein had a pre-arranged catalytic site, with strong electrostatic interactions between the active-site residues His-265 and Asp-267.	Aspartic Acid	137-140	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	4-9
32241910-8	2020	Asp-113 is highly conserved among Nobo proteins, but not among other GSTs, implying that this residue is important for endogenous Nobo function.	Aspartic Acid	0-3	Glutathione S transferase E14	Drosophila melanogaster	34-38
32241910-8	2020	Asp-113 is highly conserved among Nobo proteins, but not among other GSTs, implying that this residue is important for endogenous Nobo function.	Aspartic Acid	0-3	Glutathione S transferase E14	Drosophila melanogaster	130-134
32380971-11	2020	RESULTS: Among the target sequencing results of 527 patients, two novel mutations (Mut1: c.821A > G p.G274D, the adenine(A) was mutated to guanine(G) at position 821 of the SRF gene coding sequences (CDS), lead to the Glycine(G) mutated to Asparticacid(D) at position 274 of the SRF protein amino acid sequences; Mut2: c.880G > T p.G294C, the guanine(G) was mutated to thymine (T) at position 880 of the SRF CDS, lead to the Glycine(G) mutated to Cysteine (C) at position 294 of the SRF protein amino acid sequences.)	Aspartic Acid	240-252	serum response factor	Homo sapiens	173-176
32302123-0	2020	First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.	Aspartic Acid	138-147	nitric oxide synthase 1	Homo sapiens	64-94
32302123-5	2020	X-ray crystallography indicates that the amino groups of some compounds occupy a water-filled pocket surrounding an nNOS-specific aspartate residue (absent in eNOS).	Aspartic Acid	130-139	nitric oxide synthase 1	Homo sapiens	116-120
32302123-5	2020	X-ray crystallography indicates that the amino groups of some compounds occupy a water-filled pocket surrounding an nNOS-specific aspartate residue (absent in eNOS).	Aspartic Acid	130-139	nitric oxide synthase 3	Homo sapiens	159-163
32380971-11	2020	RESULTS: Among the target sequencing results of 527 patients, two novel mutations (Mut1: c.821A > G p.G274D, the adenine(A) was mutated to guanine(G) at position 821 of the SRF gene coding sequences (CDS), lead to the Glycine(G) mutated to Asparticacid(D) at position 274 of the SRF protein amino acid sequences; Mut2: c.880G > T p.G294C, the guanine(G) was mutated to thymine (T) at position 880 of the SRF CDS, lead to the Glycine(G) mutated to Cysteine (C) at position 294 of the SRF protein amino acid sequences.)	Aspartic Acid	240-252	serum response factor	Homo sapiens	279-282
32380971-11	2020	RESULTS: Among the target sequencing results of 527 patients, two novel mutations (Mut1: c.821A > G p.G274D, the adenine(A) was mutated to guanine(G) at position 821 of the SRF gene coding sequences (CDS), lead to the Glycine(G) mutated to Asparticacid(D) at position 274 of the SRF protein amino acid sequences; Mut2: c.880G > T p.G294C, the guanine(G) was mutated to thymine (T) at position 880 of the SRF CDS, lead to the Glycine(G) mutated to Cysteine (C) at position 294 of the SRF protein amino acid sequences.)	Aspartic Acid	240-252	serum response factor	Homo sapiens	279-282
31916309-4	2020	Serum CHI3L1 expression levels were positively associated with liver stiffness measurement (LSM), fibrosis-4 (FIB-4) index, aspartate aminotransferase-to-platelet ratio index (APRI), and HCC stage.	Aspartic Acid	124-133	chitinase 3 like 1	Homo sapiens	6-12
32139596-5	2020	Specifically, we find that proinsulin Tyr-B16, which is a key residue in normal proinsulin dimerization, helps confer dominant-negative behavior of MIDY mutant proinsulin-C(A7)Y. Substitutions of Tyr-B16 with ether Ala, Asp, or Pro in proinsulin-C(A7)Y each decrease the abnormal interactions between the MIDY mutant and proinsulin-WT, rescuing proinsulin-WT export, limiting ER stress, and increasing insulin production in beta-cells and human islets.	Aspartic Acid	220-223	insulin	Homo sapiens	27-37
31958766-11	2020	Aspartate and l-cysteine were selected as key metabolites and correlated proteins such as IL4I1 and ASPA were speculated as the potential target to treat LPS-induced lung injury using PDL.	Aspartic Acid	0-9	aspartoacylase	Mus musculus	100-104
32159413-8	2020	To further support our hypothesis, we generated alanine and phosphomimetic (aspartic acid) mutants of TNFR1 at positions T411 and T417, ectopically expressed these mutants, and determined their influence on TNF-alpha-induced activations of ERKs, AKT, STAT3, p38alpha, and JNK1/2.	Aspartic Acid	76-89	TNF receptor superfamily member 1A	Homo sapiens	102-107
32367316-6	2020	The results of this study showed a novel variant in the C5ORF42 gene c.3080A > T: p. D1027V leading to a substitution of a valine for aspartic acid (D1027V) and may be associated with JS.	Aspartic Acid	134-147	ciliogenesis and planar polarity effector complex subunit 1	Homo sapiens	56-63
32313203-9	2020	Thus, voltage-dependent protonation of glutamate/aspartate residues (Glu/Asp) located in the Ca2+-binding pocket underlines TMEM16A activation in the absence of intracellular Ca2+.	Aspartic Acid	49-58	anoctamin 1	Homo sapiens	124-131
32313203-9	2020	Thus, voltage-dependent protonation of glutamate/aspartate residues (Glu/Asp) located in the Ca2+-binding pocket underlines TMEM16A activation in the absence of intracellular Ca2+.	Aspartic Acid	73-76	anoctamin 1	Homo sapiens	124-131
32122970-8	2020	Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death.	Aspartic Acid	110-113	caspase 1	Mus musculus	14-23
32122970-8	2020	Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death.	Aspartic Acid	110-113	caspase 8	Mus musculus	36-45
32122970-8	2020	Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death.	Aspartic Acid	110-113	ring finger protein 31	Mus musculus	102-106
32122970-8	2020	Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death.	Aspartic Acid	122-125	caspase 1	Mus musculus	14-23
32122970-8	2020	Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death.	Aspartic Acid	122-125	caspase 8	Mus musculus	36-45
32273511-5	2020	Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity.	Aspartic Acid	32-41	serine/threonine kinase 11	Homo sapiens	105-109
32273511-5	2020	Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity.	Aspartic Acid	32-41	serine/threonine kinase 11	Homo sapiens	136-140
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Aspartic Acid	139-148	tumor protein p53	Homo sapiens	20-23
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Aspartic Acid	139-148	serine/threonine kinase 11	Homo sapiens	158-162
32273511-6	2020	Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling.	Aspartic Acid	139-148	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	163-167
32273511-7	2020	Our findings highlight a role for LKB1 in sensing asparagine and aspartate and connect asparagine metabolism to the cellular signalling transduction network that modulates cell survival.	Aspartic Acid	65-74	serine/threonine kinase 11	Homo sapiens	34-38
32119557-4	2020	Salt formation between CAR with ASP or GLU was expected to occur at the molar 1:1 ratio based on their chemical structures.	Aspartic Acid	32-35	CXADR pseudogene 1	Homo sapiens	23-26
32119557-5	2020	Interestingly, the largest deviation between the experimental Tg and the theoretical Tg based on the Gordon-Taylor equation was observed at a molar ratio of around 1:1.5 in CAR-ASP and CAR-GLU systems.	Aspartic Acid	177-180	CXADR pseudogene 1	Homo sapiens	173-176
32694660-4	2020	When protective, glucose metabolism augments anaplerotic input into the TCA cycle via pyruvate carboxylase (PC) activity, leading to increased aspartate levels.	Aspartic Acid	143-152	pyruvate carboxylase	Homo sapiens	86-106
32144209-9	2020	We found that Asn (polar) and Asp (charged) activate PKM2 and that Val (hydrophobic) inhibits it.	Aspartic Acid	30-33	pyruvate kinase M1/2	Homo sapiens	53-57
32144209-10	2020	The results also indicate that both Asn and Asp can restore the activity of Val-inhibited PKM2.	Aspartic Acid	44-47	pyruvate kinase M1/2	Homo sapiens	90-94
32273511-0	2020	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival.	Aspartic Acid	24-33	tumor protein p53	Homo sapiens	0-3
32273511-0	2020	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival.	Aspartic Acid	24-33	serine/threonine kinase 11	Homo sapiens	66-70
32273511-1	2020	Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine.	Aspartic Acid	71-80	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
32273511-1	2020	Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine.	Aspartic Acid	71-80	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
32273511-3	2020	Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS expression and disrupts asparagine-aspartate homeostasis, leading to lymphoma and colon tumour growth inhibition in vivo and in vitro.	Aspartic Acid	143-152	tumor protein p53	Homo sapiens	21-24
32273511-5	2020	Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity.	Aspartic Acid	32-41	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	51-55
32273511-5	2020	Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity.	Aspartic Acid	32-41	tumor protein p53	Homo sapiens	65-68
32245432-0	2020	Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation.	Aspartic Acid	20-29	ANI_1_820034	Aspergillus niger CBS 513.88	53-65
32245432-3	2020	RESULTS: In the previous study combined multi-omics integrative analysis and amino acid supplementation experiment, we predicted four amino acids (alanine, glutamate, glycine and aspartate) as the limited precursors for glucoamylase production in A. niger.	Aspartic Acid	179-188	ANI_1_820034	Aspergillus niger CBS 513.88	220-232
32245432-6	2020	Notably, the results demonstrated that mutant OE-asp2 which was constructed for reinforcing cytosolic aspartate synthetic pathway, exhibited significantly increased glucoamylase activity by 23.5% and 60.3% compared to CBS 513.88 in the cultivation of shake flask and the 5 L fermentor, respectively.	Aspartic Acid	102-111	ANI_1_820034	Aspergillus niger CBS 513.88	165-177
32252459-5	2020	Molecular models in both closed and open states provided evidence for interactions between R33 and aspartic acid at position 354 (D354) of the neighboring TM2 segment.	Aspartic Acid	99-112	tropomyosin 1, alpha	Mus musculus	155-158
32337688-4	2020	Moreover, inflammatory cytokines IL-6 and TNF-a were decreased strikingly in CFA-induced arthritic rats after treatment of ASP.	Aspartic Acid	123-126	interleukin 6	Rattus norvegicus	33-37
32337688-5	2020	Evidence also showed that ASP strongly inhibited hepcidin expression through the Janus kinase/signal transducers and activators of transcription (JAK2/STAT3) pathway.	Aspartic Acid	26-29	hepcidin antimicrobial peptide	Rattus norvegicus	49-57
32337688-5	2020	Evidence also showed that ASP strongly inhibited hepcidin expression through the Janus kinase/signal transducers and activators of transcription (JAK2/STAT3) pathway.	Aspartic Acid	26-29	Janus kinase 2	Rattus norvegicus	146-150
32337688-5	2020	Evidence also showed that ASP strongly inhibited hepcidin expression through the Janus kinase/signal transducers and activators of transcription (JAK2/STAT3) pathway.	Aspartic Acid	26-29	signal transducer and activator of transcription 3	Rattus norvegicus	151-156
32337688-7	2020	Data presented in this article collectively indicated that ASP significantly decreased proinflammatory cytokines (TNF-a, IL-6), which might play a crucial role in the CFA-induced arthritic rats, and had a therapeutic effect on adjuvant arthritis in rats.	Aspartic Acid	59-62	interleukin 6	Rattus norvegicus	121-125
32337688-8	2020	Results of Western blot analysis indicated that ASP inhibited the activation of IL-6/JAK2/STAT3 signaling pathway in the CFA-induced arthritic rats.	Aspartic Acid	48-51	interleukin 6	Rattus norvegicus	80-84
32337688-8	2020	Results of Western blot analysis indicated that ASP inhibited the activation of IL-6/JAK2/STAT3 signaling pathway in the CFA-induced arthritic rats.	Aspartic Acid	48-51	Janus kinase 2	Rattus norvegicus	85-89
32337688-8	2020	Results of Western blot analysis indicated that ASP inhibited the activation of IL-6/JAK2/STAT3 signaling pathway in the CFA-induced arthritic rats.	Aspartic Acid	48-51	signal transducer and activator of transcription 3	Rattus norvegicus	90-95
32081808-4	2020	The predicted protein of On-DDX41 contains several structural features known in DDX41, including conserved DEADc and HELICc domains, and a conserved sequence "Asp-Glu-Ala-Asp (D-E-A-D)".	Aspartic Acid	159-162	probable ATP-dependent RNA helicase DDX41	Oreochromis niloticus	28-33
32081808-4	2020	The predicted protein of On-DDX41 contains several structural features known in DDX41, including conserved DEADc and HELICc domains, and a conserved sequence "Asp-Glu-Ala-Asp (D-E-A-D)".	Aspartic Acid	171-174	probable ATP-dependent RNA helicase DDX41	Oreochromis niloticus	28-33
31880002-11	2020	HMW APN was significantly associated with fasting plasma glucose (R = .350, P = .016), alanine aminotransferase (R = -.321, P = .029), and aspartate aminotransferase (R = -.295, P = .045).	Aspartic Acid	139-148	adiponectin, C1Q and collagen domain containing	Homo sapiens	4-7
32274211-0	2020	Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and Coronary Artery Injury in Children with Kawasaki Disease.	Aspartic Acid	45-54	solute carrier family 17 member 5	Homo sapiens	79-82
32281744-2	2020	Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-beta at sites of injury and by providing myofibroblasts information about the composition and stiffness of the extracellular matrix.	Aspartic Acid	17-30	transforming growth factor alpha	Mus musculus	129-137
31498440-8	2020	When Ser727 of STAT3 mutated to Asp, the capacity of STAT3 to accumulate in the nucleus was attenuated, STAT3-induced cell survival was impaired and GCDA-induced chemoresistance was abolished.	Aspartic Acid	32-35	signal transducer and activator of transcription 3	Homo sapiens	15-20
32382474-6	2020	It is also found that the active site of aspartic acid (ASP) residues in APH (2"") is thermally unstable from the results of molecular dynamics simulation.	Aspartic Acid	41-54	acylaminoacyl-peptide hydrolase	Homo sapiens	73-76
32382474-6	2020	It is also found that the active site of aspartic acid (ASP) residues in APH (2"") is thermally unstable from the results of molecular dynamics simulation.	Aspartic Acid	56-59	acylaminoacyl-peptide hydrolase	Homo sapiens	73-76
32155178-6	2020	Serum biomarkers of liver injury increased in both CDAHFD-fed female and male mice; however CDAHFD-fed Cyp2b-null females exhibited significantly lower serum ALT, AST, and ASP concentrations compared to WT mice, indicating Cyp2b-null females were protected from liver injury.	Aspartic Acid	172-175	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	103-108
32123248-3	2020	Our recent study suggests that caspase-2 (Casp2)-catalyzed tau cleavage at aspartate 314 mediates synaptic dysfunction and memory impairment in mouse and cellular models of neurodegenerative disorders.	Aspartic Acid	75-84	caspase 2	Mus musculus	31-40
32123248-3	2020	Our recent study suggests that caspase-2 (Casp2)-catalyzed tau cleavage at aspartate 314 mediates synaptic dysfunction and memory impairment in mouse and cellular models of neurodegenerative disorders.	Aspartic Acid	75-84	caspase 2	Mus musculus	42-47
32123248-3	2020	Our recent study suggests that caspase-2 (Casp2)-catalyzed tau cleavage at aspartate 314 mediates synaptic dysfunction and memory impairment in mouse and cellular models of neurodegenerative disorders.	Aspartic Acid	75-84	microtubule associated protein tau	Homo sapiens	59-62
32219097-7	2020	Moreover, LPD mice exhibited decreased concentrations of gamma-aminobutyric acid (GABA), glutamate, glycine, dopamine, norepinephrine, serotonin and aspartate in the brain.	Aspartic Acid	149-158	acyl-CoA synthetase bubblegum family member 1	Mus musculus	10-13
32498570-0	2020	Severe alpha-Thalassemia Due to Compound Heterozygosity for Hb Adana (alpha59 Gly>Asp) (HBA1: c.179G > A) and Codon 127 (A > T) (HBA2: c.382A > T) in an Iranian Family.	Aspartic Acid	82-85	hemoglobin subunit alpha 1	Homo sapiens	88-92
31498440-8	2020	When Ser727 of STAT3 mutated to Asp, the capacity of STAT3 to accumulate in the nucleus was attenuated, STAT3-induced cell survival was impaired and GCDA-induced chemoresistance was abolished.	Aspartic Acid	32-35	signal transducer and activator of transcription 3	Homo sapiens	53-58
31498440-8	2020	When Ser727 of STAT3 mutated to Asp, the capacity of STAT3 to accumulate in the nucleus was attenuated, STAT3-induced cell survival was impaired and GCDA-induced chemoresistance was abolished.	Aspartic Acid	32-35	signal transducer and activator of transcription 3	Homo sapiens	53-58
32292439-1	2020	Objective: To investigate the association of gold standard liver biomarkers with serum cytokeratin 18 (CK18), serum Alanine aminotransferase (ALT) and serum aspartate (AST).	Aspartic Acid	157-166	solute carrier family 17 member 5	Homo sapiens	168-171
32103179-8	2020	Functional analysis of ALG6 variants identified a catalytic aspartate residue that probably acts as a general base.	Aspartic Acid	60-69	dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase	Saccharomyces cerevisiae S288C	23-27
32028527-3	2020	These post-translational modification events are predominantly serine-linked and require HPF1, an accessory factor that is specific for the DNA damage response and switches the amino-acid specificity of PARP1/2 from aspartate/glutamate to serine residues5-10.	Aspartic Acid	216-225	histone PARylation factor 1	Homo sapiens	89-93
32028527-3	2020	These post-translational modification events are predominantly serine-linked and require HPF1, an accessory factor that is specific for the DNA damage response and switches the amino-acid specificity of PARP1/2 from aspartate/glutamate to serine residues5-10.	Aspartic Acid	216-225	poly(ADP-ribose) polymerase 1	Homo sapiens	203-208
31761395-10	2020	Hepatic glypican-3 expression was associated with age, albumin, aspartate transaminase, and alkaline phosphatase in biliary atresia patients, while hepatic alpha-smooth muscle actin expression was correlated with alkaline phosphatase in the patients.	Aspartic Acid	64-73	glypican 3	Homo sapiens	8-18
31855746-0	2020	Dentin phosphoprotein inhibits lipopolysaccharide-induced macrophage activation independent of its serine/aspartic acid-rich repeats.	Aspartic Acid	106-119	dentin sialophosphoprotein	Homo sapiens	0-21
31907178-2	2020	Hydroxylamine (HYD) and carboxymethoxylamine (CAR) have been reported as inhibitors of aspartate aminotransferases (AATs), and interferes with the proliferation in Plasmodium falciparum Therefore, AATs are suggested as drug targets against Plasmodium T. gondii genome encodes only one predicted AAT in both T. gondii type I RH and type II PLK strains.	Aspartic Acid	87-96	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	116-119
31922154-3	2020	Herein, we have developed the first high-throughput profiling technique for all 20 isobaric Abeta peptide epimers containing Asp, isoAsp, and Ser isomers using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).	Aspartic Acid	125-128	amyloid beta precursor protein	Homo sapiens	92-97
31922154-4	2020	This new analytical strategy allows the direct detection and identification of all possible Asp, isoAsp, and Ser stereoisomers in Abeta, and may contribute to a better understanding of the pathogenesis of AD.	Aspartic Acid	92-95	amyloid beta precursor protein	Homo sapiens	130-135
32020477-7	2020	L-asparaginase hydrolyzes asparagine into aspartate and depletes asparagine.	Aspartic Acid	42-51	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
32010304-4	2020	BS significantly ameliorated CCl4-induced increases in serum aspartate (AST) and alanine transaminase (ALT) levels, reduced lactate dehydrogenase (LDH) activities in addition to restoring total bilirubin, triglyceride and albumin levels.	Aspartic Acid	61-70	C-C motif chemokine ligand 4	Rattus norvegicus	29-33
31819005-8	2020	We also found that Glu-499 and Asp-647 in AtGCD3 are vital for GCD activity.	Aspartic Acid	31-34	glucosylceramidase beta	Homo sapiens	44-47
31910706-5	2020	Caspases (cysteine aspartic proteases and cysteine aspartases) are cysteine dependent aspartate-specific proteases.	Aspartic Acid	86-95	caspase 8	Homo sapiens	0-8
31978345-6	2020	FAMIN enables in macrophages a purine nucleotide cycle (PNC) between adenosine and inosine monophosphate and adenylosuccinate, which consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity.	Aspartic Acid	142-151	laccase domain containing 1	Homo sapiens	0-5
31968674-2	2020	Especially, degradation signaling of N-terminal asparagine (Nt-Asn) in eukaryotes is initiated from its deamidation by N-terminal asparagine amidohydrolase 1 (NTAN1) into aspartate.	Aspartic Acid	171-180	N-terminal asparagine amidase	Homo sapiens	119-157
31968674-2	2020	Especially, degradation signaling of N-terminal asparagine (Nt-Asn) in eukaryotes is initiated from its deamidation by N-terminal asparagine amidohydrolase 1 (NTAN1) into aspartate.	Aspartic Acid	171-180	N-terminal asparagine amidase	Homo sapiens	159-164
31709908-8	2020	Furthermore, aspartate supplementation was sufficient to reverse the anti-hypertrophic effect of ACC2 deletion demonstrating a causal role of elevated aspartate level in CM hypertrophy.	Aspartic Acid	13-22	acetyl-CoA carboxylase beta	Rattus norvegicus	97-101
31709908-8	2020	Furthermore, aspartate supplementation was sufficient to reverse the anti-hypertrophic effect of ACC2 deletion demonstrating a causal role of elevated aspartate level in CM hypertrophy.	Aspartic Acid	151-160	acetyl-CoA carboxylase beta	Rattus norvegicus	97-101
31885210-4	2020	Significant higher OPN expression is found in foam cells along with the aggravating capacity of macrophage recruitment due to its arginine-glycine-aspartate sequence and interaction with CD44.	Aspartic Acid	147-156	secreted phosphoprotein 1	Mus musculus	19-22
32881518-0	2020	Relative Quantitation of Beta-Amyloid Peptide Isomers with Simultaneous Isomerization of Multiple Aspartic Acid Residues by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.	Aspartic Acid	98-111	amyloid beta precursor protein	Homo sapiens	25-45
31963194-9	2020	It was also confirmed that changes in aspartate (AST) and alanine (ALT) activities emerge before any increase in creatine kinase (CK) activity that is important in monitoring of the training loads.	Aspartic Acid	38-47	solute carrier family 17 member 5	Homo sapiens	49-52
31998641-1	2019	Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid asparagine (Asn) from aspartate (Asp) and glutamine (Gln).	Aspartic Acid	107-116	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
31998641-1	2019	Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid asparagine (Asn) from aspartate (Asp) and glutamine (Gln).	Aspartic Acid	107-116	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
31998641-1	2019	Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid asparagine (Asn) from aspartate (Asp) and glutamine (Gln).	Aspartic Acid	0-3	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
32955901-10	2020	Phenylalanine, tyrosine, glycine, lysine, and aspartic acid were found to be the headliner amino acids in the interactions between Arbidol and binding domains of spike glycoproteins in the SARS-CoV2 (Tab.	Aspartic Acid	46-59	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	162-167
31909745-2	2020	TRX from the extremely halophilic archaeon Halobacterium salinarum NRC-1 (HsTRX-A), which has the highest acidic residue content [(Asp + Glu)/(Arg + Lys + His) = 9.0] among known TRXs, was chosen to elucidate the catalytic mechanism and evolutionary characteristics associated with haloadaptation.	Aspartic Acid	131-134	thioredoxin family protein	Halobacterium salinarum NRC-1	0-3
31244443-10	2020	RESULTS: The residues (ASP-119, PHE-417) of D3 receptor provided a stable docking with the drug, and the important pharmacological values (blood brain barrier, cacao2 permeability and human oral absorption) were also determined.The average particle size, PdI and zeta potential value of sulpiride-loaded chitosan NPs having a spherical morphology were calculated as 96.93 nm, 0.202, and +7.91 mV.	Aspartic Acid	23-26	prolyl 4-hydroxylase subunit beta	Homo sapiens	255-258
32115530-7	2020	A surface plasmon resonance study using hTAS2R14 protein and these substances suggested that the affinity of Glu-Glu, Asp-Asp, Glu and Asp for hTAS2R14 protein was greater than that of Gly-Gly or Gly.	Aspartic Acid	118-121	taste 2 receptor member 14	Homo sapiens	40-48
32115530-7	2020	A surface plasmon resonance study using hTAS2R14 protein and these substances suggested that the affinity of Glu-Glu, Asp-Asp, Glu and Asp for hTAS2R14 protein was greater than that of Gly-Gly or Gly.	Aspartic Acid	118-121	taste 2 receptor member 14	Homo sapiens	143-151
32115530-8	2020	The results of docking-simulation studies involving DPH, Glu-Glu and Asp-Asp with hTAS2R14, suggested that DPH is able to bind to a space near the binding position of Glu-Glu and Asp-Asp.	Aspartic Acid	69-72	taste 2 receptor member 14	Homo sapiens	82-90
32115530-8	2020	The results of docking-simulation studies involving DPH, Glu-Glu and Asp-Asp with hTAS2R14, suggested that DPH is able to bind to a space near the binding position of Glu-Glu and Asp-Asp.	Aspartic Acid	73-76	taste 2 receptor member 14	Homo sapiens	82-90
32115530-8	2020	The results of docking-simulation studies involving DPH, Glu-Glu and Asp-Asp with hTAS2R14, suggested that DPH is able to bind to a space near the binding position of Glu-Glu and Asp-Asp.	Aspartic Acid	73-76	taste 2 receptor member 14	Homo sapiens	82-90
32115530-8	2020	The results of docking-simulation studies involving DPH, Glu-Glu and Asp-Asp with hTAS2R14, suggested that DPH is able to bind to a space near the binding position of Glu-Glu and Asp-Asp.	Aspartic Acid	73-76	taste 2 receptor member 14	Homo sapiens	82-90
33200028-4	2020	Here, we observed Val-to-Lys417 mutation in the receptor-binding domains (RBD) of SARS-CoV-2, which established a Lys-Asp electrostatic interaction enhancing its ACE2-binding.	Aspartic Acid	118-121	angiotensin converting enzyme 2	Homo sapiens	162-166
32067605-10	2020	Compared with placebo, selective VEGFR inhibitors significantly increased the PFS rate, SD, PR and DCR, reduced PD, caused more treatment-emergent adverse events (TEAEs), hypertension, hand-foot skin reaction, diarrhoea, fatigue, and thrombocytopaenia and increased aspartate aminotransferase(AST) concentration.	Aspartic Acid	266-275	kinase insert domain receptor	Homo sapiens	33-38
31805321-3	2020	Results showed that PSP pretreatment significantly antagonized the increases in serum alanine aminotransferase, aspartate aminotransferase, triacylglycerides, and hepatic malondialdehyde levels; elevated the antioxidant enzyme activities and hepatic glutathione levels; and suppressed the levels of hepatic inflammatory cytokines in alcohol-induced liver injury in mice (P &lt; 0.05).	Aspartic Acid	112-121	persephin	Mus musculus	20-23
32418532-13	2020	Angiotensin 1-7 can be further transformed to Alamandine (i.e. peptide ARVYIHP) by an aspartate decarboxylase.	Aspartic Acid	86-95	angiotensin 1-7	None	0-15
32418532-15	2020	Angiotensin II can produce Angiotensin A (i.e. peptide ARVYIHPF) via an aspartate decarboxylase, and Alamandine via an additional ACE2 cleavage.	Aspartic Acid	72-81	angiotensinogen	Homo sapiens	0-14
31462712-1	2020	Citrin, encoded by SLC25A13 gene, is an inner mitochondrial transporter that is part of the malate-aspartate shuttle, which regulates the NAD+/NADH ratio between the cytosol and mitochondria.	Aspartic Acid	99-108	solute carrier family 25 member 13	Homo sapiens	0-6
31895778-0	2020	The serum interleukin-26 level is a potential biomarker for chronical hepatitis B. Proinflammatory interleukin-26 (IL-26) is involved in chronic inflammation; however, the role of IL-26 in chronic hepatitis B (CHB) remains unknown.In this study, serum IL-26 was quantified in a cohort of CHB patients at baseline and during telbivudine (LdT) treatment.Our results showed that the serum IL-26 level was significantly elevated in CHB patients compared with that in healthy controls and was time-dependently decreased during LdT treatment, accompanying hepatitis B e antigen (HBeAg) seroconversion and reduced serum levels of hepatitis B virus (HBV) DNA, aspartate transaminase, and alanine transaminase across baseline and treatment.	Aspartic Acid	652-661	interleukin 26	Homo sapiens	115-120
32378630-2	2020	Shati/Nat8l is a synthetic enzyme that produces N-acetylaspartate (NAA) from L-aspartate and acetyl-coenzyme NAA is converted into N-acetylaspartylglutamate (NAAG) by NAAG synthetase (NAAGS).	Aspartic Acid	77-88	N-acetyltransferase 8-like	Mus musculus	0-5
32378630-2	2020	Shati/Nat8l is a synthetic enzyme that produces N-acetylaspartate (NAA) from L-aspartate and acetyl-coenzyme NAA is converted into N-acetylaspartylglutamate (NAAG) by NAAG synthetase (NAAGS).	Aspartic Acid	77-88	N-acetyltransferase 8-like	Mus musculus	6-11
32378630-2	2020	Shati/Nat8l is a synthetic enzyme that produces N-acetylaspartate (NAA) from L-aspartate and acetyl-coenzyme NAA is converted into N-acetylaspartylglutamate (NAAG) by NAAG synthetase (NAAGS).	Aspartic Acid	77-88	ribosomal modification protein rimK-like family member A	Mus musculus	167-182
32378630-2	2020	Shati/Nat8l is a synthetic enzyme that produces N-acetylaspartate (NAA) from L-aspartate and acetyl-coenzyme NAA is converted into N-acetylaspartylglutamate (NAAG) by NAAG synthetase (NAAGS).	Aspartic Acid	77-88	ribosomal modification protein rimK-like family member A	Mus musculus	184-189
31462712-1	2020	Citrin, encoded by SLC25A13 gene, is an inner mitochondrial transporter that is part of the malate-aspartate shuttle, which regulates the NAD+/NADH ratio between the cytosol and mitochondria.	Aspartic Acid	99-108	solute carrier family 25 member 13	Homo sapiens	19-27
31983877-5	2019	The transgenic plants that overexpressed SYNC1 gene had increased asparagine and lysine contents in matured seeds, and increased aspartate, lysine, alanine and histidine contents in germinated seeds.	Aspartic Acid	129-138	Class II aminoacyl-tRNA and biotin synthetases superfamily protein	Arabidopsis thaliana	41-46
31622858-4	2020	These SerR homologs exhibited racemase activity towards serine or aspartate and were identified on the basis of their maximum activity as SerR or aspartate racemase (AspR).	Aspartic Acid	66-75	serine racemase	Solanum lycopersicum	6-10
31622858-4	2020	These SerR homologs exhibited racemase activity towards serine or aspartate and were identified on the basis of their maximum activity as SerR or aspartate racemase (AspR).	Aspartic Acid	146-155	serine racemase	Solanum lycopersicum	6-10
31622858-7	2020	Phylogenetic tree analysis showed that SerR and AspR are widely distributed in plants and form a serine/aspartate racemase family cluster.	Aspartic Acid	104-113	serine racemase	Solanum lycopersicum	39-43
31102177-6	2020	Furthermore, the mRNA expression of CAT, CuZnSOD, and GPx4 was altered in the testes and epididymis of boars treated with Asp and Glu.	Aspartic Acid	122-125	catalase	Homo sapiens	36-39
31102177-6	2020	Furthermore, the mRNA expression of CAT, CuZnSOD, and GPx4 was altered in the testes and epididymis of boars treated with Asp and Glu.	Aspartic Acid	122-125	glutathione peroxidase 4	Homo sapiens	54-58
31102177-7	2020	Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis.	Aspartic Acid	8-11	transforming growth factor beta 1	Homo sapiens	61-70
31102177-7	2020	Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis.	Aspartic Acid	8-11	interleukin 10	Homo sapiens	72-77
31102177-7	2020	Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis.	Aspartic Acid	8-11	tumor necrosis factor	Homo sapiens	79-88
31192586-2	2019	Counterintuitively, crystal structures of CatA and its homologues show a cluster of Glu and Asp residues binding the C-terminal carboxylic acid of the product or inhibitor.	Aspartic Acid	92-95	cathepsin A	Homo sapiens	42-46
31911926-0	2019	Isolated elevated aspartate aminotransferase in an asymptomatic woman due to macro-aspartate aminotransferase: A case report.	Aspartic Acid	18-27	solute carrier family 17 member 5	Homo sapiens	77-109
33306174-4	2020	Although initial reports suggested that the microtubule-stabilizing activity of the taccalonolides was independent of direct tubulin binding, additional studies have identified that potent C-22, C-23 epoxidized taccalonolides covalently bind the Aspartate 226 residue of beta-tubulin and that this interaction is critical for their microtubule-stabilizing activity.	Aspartic Acid	246-255	nucleolin	Homo sapiens	195-199
31102177-7	2020	Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis.	Aspartic Acid	8-11	interleukin 6	Homo sapiens	90-94
31102177-7	2020	Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis.	Aspartic Acid	8-11	interleukin 1 beta	Homo sapiens	99-107
31903153-10	2020	Arg deprivation in ASS1-deficient PDAC cells upregulated asparagine synthetase (ASNS) which redirected aspartate (Asp) from being used for de novo nucleotide biosynthesis, thus causing nucleotide insufficiency and impairing cell cycle S-phase progression.	Aspartic Acid	103-112	argininosuccinate synthase 1	Homo sapiens	19-23
31903153-10	2020	Arg deprivation in ASS1-deficient PDAC cells upregulated asparagine synthetase (ASNS) which redirected aspartate (Asp) from being used for de novo nucleotide biosynthesis, thus causing nucleotide insufficiency and impairing cell cycle S-phase progression.	Aspartic Acid	103-112	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	57-78
31903153-10	2020	Arg deprivation in ASS1-deficient PDAC cells upregulated asparagine synthetase (ASNS) which redirected aspartate (Asp) from being used for de novo nucleotide biosynthesis, thus causing nucleotide insufficiency and impairing cell cycle S-phase progression.	Aspartic Acid	103-112	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	80-84
31903153-10	2020	Arg deprivation in ASS1-deficient PDAC cells upregulated asparagine synthetase (ASNS) which redirected aspartate (Asp) from being used for de novo nucleotide biosynthesis, thus causing nucleotide insufficiency and impairing cell cycle S-phase progression.	Aspartic Acid	114-117	argininosuccinate synthase 1	Homo sapiens	19-23
31903153-10	2020	Arg deprivation in ASS1-deficient PDAC cells upregulated asparagine synthetase (ASNS) which redirected aspartate (Asp) from being used for de novo nucleotide biosynthesis, thus causing nucleotide insufficiency and impairing cell cycle S-phase progression.	Aspartic Acid	114-117	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	57-78
31903153-10	2020	Arg deprivation in ASS1-deficient PDAC cells upregulated asparagine synthetase (ASNS) which redirected aspartate (Asp) from being used for de novo nucleotide biosynthesis, thus causing nucleotide insufficiency and impairing cell cycle S-phase progression.	Aspartic Acid	114-117	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	80-84
31842908-9	2019	PMN elastase level and ENR were positively correlated with myositis disease activity assessment, CK, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, C-reactive protein, and erythrocyte sedimentation rate.	Aspartic Acid	124-133	elastase, neutrophil expressed	Homo sapiens	0-12
31825842-4	2019	During apoptosis, OTULIN is cleaved by capase-3 at Asp-31 into a C-terminal fragment that restricts caspase activation and cell death.	Aspartic Acid	51-54	OTU deubiquitinase with linear linkage specificity	Homo sapiens	18-24
31638418-1	2019	N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate.	Aspartic Acid	8-17	N-acetyltransferase 8-like	Mus musculus	42-71
30867554-5	2019	Healthy donor-derived and lysate- or peptide-pulsed Asp-STs presented comparable fold expansion, immunophenotype, and Th1 responses.	Aspartic Acid	52-55	negative elongation factor complex member C/D	Homo sapiens	118-121
31817360-5	2019	We observed increased labeling of malate and aspartate in A549 GLUL KO cells, whereas the non-resistant GLUL KO H1299 cells displayed decreased 13C-labeling.	Aspartic Acid	45-54	glutamate-ammonia ligase	Homo sapiens	63-67
31772648-11	2019	After CXCL9 administration, WT mice exhibited higher serum levels of aspartate transaminase and increased caspase-3 and caspase-8 activity in liver tissue compared with controls.	Aspartic Acid	69-78	chemokine (C-X-C motif) ligand 9	Mus musculus	6-11
31638418-1	2019	N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate.	Aspartic Acid	8-17	N-acetyltransferase 8-like	Mus musculus	79-84
31718395-4	2019	In ICR mice, PU ameliorated the CCl4-induced increase of the serum aspartate aminotransferase, alanine aminotransferase, the activity of liver lactate dehydrogenase, and the damage of histopathological structure, and exhibited a hepatoprotective effect against CCl4.	Aspartic Acid	67-76	chemokine (C-C motif) ligand 4	Mus musculus	32-36
31711143-0	2019	Over-expression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p.	Aspartic Acid	113-122	Pex34p	Saccharomyces cerevisiae S288C	31-37
31538237-2	2019	MDH plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle.	Aspartic Acid	40-49	malate dehydrogenase 1	Homo sapiens	0-3
31538237-11	2019	In MDH1 KO HEK293 cells, increased levels of glycerol-3-phosphate were also observed, as well as increased levels of aspartate and decreased levels of fumarate.	Aspartic Acid	117-126	malate dehydrogenase 1	Homo sapiens	3-7
31880113-5	2019	CMECs with downregulation of spartin expression were firstly treated with anti-oxidant N-acetylcysteine (NAC) or Asp respectively for 48 h, and then were interfered with 30 mmol/L glucose for 24 h afterward.	Aspartic Acid	113-116	spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)	Mus musculus	29-36
31699650-5	2019	At DOL 20, aldh5a1-/- mice had elevated C6 dicarboxylic (adipic acid) and C14 carnitines and threonine, combined with a significantly elevated ratio of threonine/[aspartic acid + alanine], in comparison to aldh5a1+/+ mice.	Aspartic Acid	163-176	aldhehyde dehydrogenase family 5, subfamily A1	Mus musculus	11-18
31749344-8	2019	Among them, the mutations at negatively charged residues (glutamate and aspartate) substantially decreased the currents of nvTRPM2 and hTRPM2.	Aspartic Acid	72-81	transient receptor potential cation channel subfamily M member 2	Homo sapiens	135-141
31472174-4	2019	Aralar/slc25a12/AGC1 is the neuronal isoform of the aspartate-glutamate mitochondrial carrier, a component of the malate-aspartate shuttle (MAS) which plays an important role in redox balance, which is essential to maintain glycolytic pyruvate supply to neuronal mitochondria.	Aspartic Acid	52-61	solute carrier family 25 member 12	Homo sapiens	0-6
31472174-4	2019	Aralar/slc25a12/AGC1 is the neuronal isoform of the aspartate-glutamate mitochondrial carrier, a component of the malate-aspartate shuttle (MAS) which plays an important role in redox balance, which is essential to maintain glycolytic pyruvate supply to neuronal mitochondria.	Aspartic Acid	52-61	solute carrier family 25 member 12	Homo sapiens	7-15
31472174-4	2019	Aralar/slc25a12/AGC1 is the neuronal isoform of the aspartate-glutamate mitochondrial carrier, a component of the malate-aspartate shuttle (MAS) which plays an important role in redox balance, which is essential to maintain glycolytic pyruvate supply to neuronal mitochondria.	Aspartic Acid	52-61	solute carrier family 25 member 12	Homo sapiens	16-20
31472174-4	2019	Aralar/slc25a12/AGC1 is the neuronal isoform of the aspartate-glutamate mitochondrial carrier, a component of the malate-aspartate shuttle (MAS) which plays an important role in redox balance, which is essential to maintain glycolytic pyruvate supply to neuronal mitochondria.	Aspartic Acid	121-130	solute carrier family 25 member 12	Homo sapiens	0-6
31472174-4	2019	Aralar/slc25a12/AGC1 is the neuronal isoform of the aspartate-glutamate mitochondrial carrier, a component of the malate-aspartate shuttle (MAS) which plays an important role in redox balance, which is essential to maintain glycolytic pyruvate supply to neuronal mitochondria.	Aspartic Acid	121-130	solute carrier family 25 member 12	Homo sapiens	7-15
31472174-4	2019	Aralar/slc25a12/AGC1 is the neuronal isoform of the aspartate-glutamate mitochondrial carrier, a component of the malate-aspartate shuttle (MAS) which plays an important role in redox balance, which is essential to maintain glycolytic pyruvate supply to neuronal mitochondria.	Aspartic Acid	121-130	solute carrier family 25 member 12	Homo sapiens	16-20
31880113-18	2019	However, intervention effects of Asp, such as decreasing of ROS production, inhibiting apoptosis of CMECs and increasing of NO production, were partly reversed in spartin downregulated cells.	Aspartic Acid	33-36	spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)	Mus musculus	163-170
31880113-20	2019	CONCLUSION: Asp can inhibit oxidative stress in mice CMECs through upregulating spartin signaling pathway, thereby alleviating the damage of microvascular endothelium in diabetic heart.	Aspartic Acid	12-15	spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)	Mus musculus	80-87
31558604-8	2019	We propose that IGF-1 Glu-58 interacts with IGF-1R Arg-704 and belongs to IGF-1 site 1, a finding supported by the NMR structure of the less active Asp-58-IGF-1 variant.	Aspartic Acid	148-151	insulin like growth factor 1	Homo sapiens	16-21
31697912-1	2019	Recent investigations of rodent Tmem163 suggest that it binds to and transports zinc as a dimer, and that alanine mutagenesis of its two species-conserved aspartate (D123A/D127A) residues proposed to bind zinc, perturbs protein function.	Aspartic Acid	155-164	transmembrane protein 163	Homo sapiens	32-39
31697912-8	2019	To further characterize the efflux function of TMEM163, we substituted alanine in two homologous aspartate residues (D124A/D128A) and performed site-directed mutagenesis of several conserved amino acid residues identified as non-synonymous single nucleotide polymorphism (S61R, S95C, S193P, and E286K).	Aspartic Acid	97-106	transmembrane protein 163	Homo sapiens	47-54
31819564-0	2019	The Relationship Between Aspartate Aminotransferase To Alanine Aminotransferase Ratio And Metabolic Syndrome In Adolescents In Northeast China.	Aspartic Acid	25-34	glutamic--pyruvic transaminase	Homo sapiens	55-79
31819564-1	2019	Aim: To investigate the relationship of the aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT) and metabolic syndrome (MetS) in adolescents in northeast China.	Aspartic Acid	44-53	glutamic--pyruvic transaminase	Homo sapiens	74-98
31675069-3	2019	All caspases prefer an aspartate residue at the P1 position of substrates, so each caspase evolved discrete cellular roles through changes in substrate recognition at the P4 position combined with allosteric regulation.	Aspartic Acid	23-32	caspase 6	Homo sapiens	4-12
32063719-1	2019	The macroenzyme form of aspartate aminotransferase (macro-AST) is formed by the binding of AST with immunoglobulins.	Aspartic Acid	24-33	solute carrier family 17 member 5	Homo sapiens	58-61
32063719-1	2019	The macroenzyme form of aspartate aminotransferase (macro-AST) is formed by the binding of AST with immunoglobulins.	Aspartic Acid	24-33	solute carrier family 17 member 5	Homo sapiens	91-94
31819564-1	2019	Aim: To investigate the relationship of the aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT) and metabolic syndrome (MetS) in adolescents in northeast China.	Aspartic Acid	44-53	solute carrier family 17 member 5	Homo sapiens	106-109
31403263-1	2019	Aspartate-glutamate carrier 1 (AGC1) is one of two exchangers within the malate-aspartate shuttle.	Aspartic Acid	80-89	solute carrier family 25 member 12	Homo sapiens	0-29
31718082-12	2019	Taken together, perturbations in tryptophan degradation and increased availability of aspartate suggest a link of DOCK8 deficiency to oncogenesis.	Aspartic Acid	86-95	dedicator of cytokinesis 8	Homo sapiens	114-119
31403263-1	2019	Aspartate-glutamate carrier 1 (AGC1) is one of two exchangers within the malate-aspartate shuttle.	Aspartic Acid	80-89	solute carrier family 25 member 12	Homo sapiens	31-35
31520600-7	2019	Charge restoration via substitution of an internal aspartate by asparagine improved potency, achieving low nM apoptotic response in VEGF-activated EC.	Aspartic Acid	51-60	vascular endothelial growth factor A	Mus musculus	132-136
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Aspartic Acid	124-137	selenoprotein K	Mus musculus	30-37
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Aspartic Acid	124-137	zinc finger, DHHC domain containing 6	Mus musculus	83-88
31187393-5	2019	These studies have shown that SELENOK interacts with an enzyme in the ER membrane, DHHC6 (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain), and the SELENOK/DHHC6 complex catalyzes the transfer of acyl groups such as palmitate to cysteine residues in target proteins, i.e., palmitoylation.	Aspartic Acid	124-137	zinc finger, DHHC domain containing 6	Mus musculus	216-221
31419538-9	2019	In the 15-day SF group, L-tryptophan, myristoylcarnitine, and palmitoylcarnitine were significantly increased, while adenosine monophosphate, hypoxanthine, L-glutamate, L-aspartate, L-methionine, and glycerophosphocholine were decreased compared to the EC group.	Aspartic Acid	169-180	hepatocyte growth factor	Rattus norvegicus	14-16
31419538-10	2019	The alanine, aspartate, and glutamate metabolism pathway was observed as the common key pathway in the 15-day SF groups.	Aspartic Acid	13-22	hepatocyte growth factor	Rattus norvegicus	110-112
31391274-5	2019	UL31 residues arginine-281 (R281) and aspartic acid-282 (D282) were required for efficient NEC binding to nucleocapsids and UL25.	Aspartic Acid	38-51	nuclear egress lamina protein	Human alphaherpesvirus 1	0-4
31491074-10	2019	The in silico molecular docking and dynamics simulation studies of lead compounds affirmed their consensual binding interactions with PAS-AChE and aspartate dyad of BACE-1.	Aspartic Acid	147-156	beta-secretase 1	Homo sapiens	165-171
33437604-3	2020	In this study, we found a novel sequence variation G26A (GAT to AAT) in 5" half of TGIF1 gene (p. aspartic acid >asparagine) at a frequency of 62% (148/240, P <= 0.0001).	Aspartic Acid	98-111	TGFB induced factor homeobox 1	Homo sapiens	83-88
31391274-5	2019	UL31 residues arginine-281 (R281) and aspartic acid-282 (D282) were required for efficient NEC binding to nucleocapsids and UL25.	Aspartic Acid	38-51	DNA packaging tegument protein UL25	Human alphaherpesvirus 1	124-128
31375564-7	2019	We also report in vitro evidence that TNKS primarily directs PAR modification to glutamate/aspartate residues.	Aspartic Acid	91-100	tankyrase	Homo sapiens	38-42
31523835-6	2019	Here, we demonstrate that ASNase stimulates aspartate and glutamate consumptions, and their refilling through SLC1A3 promotes cancer cell proliferation.	Aspartic Acid	44-53	asparaginase like 1	Mus musculus	26-32
31523835-7	2019	Lastly, in vivo experiments indicated that SLC1A3 expression promoted tumor development and metastasis while negating the suppressive effects of ASNase by fueling aspartate, glutamate, and glutamine metabolisms despite of asparagine shortage.	Aspartic Acid	163-172	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	43-49
31523835-8	2019	Altogether, our findings identify a novel role for SLC1A3 in ASNase resistance and suggest that restrictive aspartate and glutamate uptake might improve ASNase efficacy with solid tumors.	Aspartic Acid	108-117	asparaginase like 1	Mus musculus	153-159
31511692-1	2019	The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL.	Aspartic Acid	4-13	caspase 8	Mus musculus	41-50
31056736-4	2019	The present study examines the effect of charged amino acids Arg, Asp, and Lys on the stability of RNase A and alpha-LA.	Aspartic Acid	66-69	ribonuclease A family member 1, pancreatic	Homo sapiens	99-106
31581577-11	2019	Among the three hits, ZINC32124535 was identified as the best potential hit based on the hydrogen bond interaction percentage with Asp residue [5HT2A (Asp 155:60%); 5HT2B (Asp155: No interaction); 5HT2C (Asp 134:86%)].	Aspartic Acid	131-134	5-hydroxytryptamine receptor 2A	Homo sapiens	144-149
31581577-11	2019	Among the three hits, ZINC32124535 was identified as the best potential hit based on the hydrogen bond interaction percentage with Asp residue [5HT2A (Asp 155:60%); 5HT2B (Asp155: No interaction); 5HT2C (Asp 134:86%)].	Aspartic Acid	131-134	5-hydroxytryptamine receptor 2C	Homo sapiens	197-202
31351182-6	2019	Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity.	Aspartic Acid	157-160	amine oxidase copper containing 1	Homo sapiens	164-168
31351182-6	2019	Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity.	Aspartic Acid	157-160	amine oxidase copper containing 2	Homo sapiens	177-181
31351182-6	2019	Furthermore, one residue located at 10 A distance from the catalytic site is different between the sub-families but highly conserved within each sub-family (Asp in AOC1, His in AOC2, Thr in AOC3 and Asn in AOC4) and likely contributes to substrate selectivity.	Aspartic Acid	157-160	amine oxidase copper containing 4, pseudogene	Homo sapiens	206-210
31371405-4	2019	Furthermore, we found that DDR-2 is N-glycosylated at the Asp-141 residue located in its discoidin domain, and mutation of this residue caused an axon regeneration defect.	Aspartic Acid	58-61	Discoidin domain-containing receptor tyrosine kinase B	Caenorhabditis elegans	27-32
31581480-9	2019	Aspartate residues 487 and 441 were identified as caspase cleavage-sites in the C-terminal coiled-coil domain of human tricellulin.	Aspartic Acid	0-9	MARVEL domain containing 2	Homo sapiens	119-130
30569833-6	2019	Therefore, these changes are qualitatively correlated to the amount of negative charge located on the 215-221 segments of IRF-1 by phosphorylation or aspartate mutation.	Aspartic Acid	150-159	interferon regulatory factor 1	Homo sapiens	122-127
31511692-1	2019	The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL.	Aspartic Acid	4-13	receptor-interacting serine-threonine kinase 3	Mus musculus	97-102
31511692-1	2019	The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL.	Aspartic Acid	4-13	mixed lineage kinase domain-like	Mus musculus	107-111
31342597-7	2019	We found that the mutation that improved stability the most (~7 C) was one which changed an amino acid in CDR1 from an asparagine to an aspartic acid.	Aspartic Acid	136-149	cerebellar degeneration related protein 1	Homo sapiens	106-110
31608236-2	2019	Unlike the other class I SLRPs (decorin and biglycan), asporin contains a unique and conserved stretch of aspartate (D) residues in its N terminus, and germline polymorphisms in the D-repeat-length are associated with osteoarthritis and prostate cancer progression.	Aspartic Acid	106-115	asporin	Homo sapiens	55-62
31635840-4	2019	The results showed that after intraperitoneal injection of CCl4 solution, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Albumin (ALB) in peripheral blood of experimental canines confirmed the correct induction of acute liver injury.	Aspartic Acid	88-97	C-C motif chemokine 4	Canis lupus familiaris	59-63
31635840-4	2019	The results showed that after intraperitoneal injection of CCl4 solution, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Albumin (ALB) in peripheral blood of experimental canines confirmed the correct induction of acute liver injury.	Aspartic Acid	88-97	albumin	Canis lupus familiaris	166-169
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	262-271	solute carrier family 25 member 12	Homo sapiens	106-141
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	0-9	solute carrier family 25 member 12	Homo sapiens	106-141
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	0-9	solute carrier family 25 member 12	Homo sapiens	143-151
31284097-2	2019	In this study, a CD133+ EPC capture surface was fabricated by grafting CD133 antibody (a more specific EPC surface marker than CD34) and Arg-Glu-Asp-Val (REDV) peptideon the methacrylate-grafted hyaluronic acid (MA-HA) and heparin-hybridized (MA-HA&amp;Heparin) resisting layer.	Aspartic Acid	145-148	prominin 1	Homo sapiens	17-22
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	262-271	solute carrier family 25 member 12	Homo sapiens	143-151
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	0-9	solute carrier family 25 member 12	Homo sapiens	31-35
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	190-199	solute carrier family 25 member 12	Homo sapiens	106-141
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	262-271	solute carrier family 25 member 12	Homo sapiens	31-35
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	190-199	solute carrier family 25 member 12	Homo sapiens	143-151
31514314-1	2019	Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate-aspartate NADH shuttle (MAS), expressed in excitable tissues only.	Aspartic Acid	190-199	solute carrier family 25 member 12	Homo sapiens	31-35
31422819-0	2019	Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.	Aspartic Acid	51-60	glutamic-oxaloacetic transaminase 2a, mitochondrial	Danio rerio	11-15
31474319-4	2019	However, aspartic acid at amino acid position 9 in HLA-B (Bpos-9) increases risk to both RA subsets.	Aspartic Acid	9-22	major histocompatibility complex, class I, B	Homo sapiens	51-56
33455163-4	2019	In this study, we uncover the interaction between an angiopoietin-1 mimetic peptide, QHREDGS (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), immobilized to a collagen-chitosan hydrogel, and murine bone marrow derived macrophages.	Aspartic Acid	137-150	angiopoietin 1	Mus musculus	53-67
31422819-9	2019	GOT2, a member of the malate-aspartate shuttle, plays an essential role in the intracellular NAD(H) redox balance.	Aspartic Acid	29-38	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	0-4
31037469-7	2019	We identify two conserved serine residues in Box 2-3 that are phosphorylated in meiosis and whose mutation to aspartate stabilises Csm1-Dsn1 binding, suggesting that regulated phosphorylation of these residues may play a role in sister kinetochore crosslinking specificity.	Aspartic Acid	110-119	Csm1p	Saccharomyces cerevisiae S288C	131-135
31062097-9	2019	In the NW group, PC-PUFA were found to be negatively associated with Delta z-BMI at 1 year in addition to some medium-chain acylcarnitines, tricarboxylic acid metabolites, Asp and Asn-to-Asp ratio.	Aspartic Acid	187-190	pumilio RNA binding family member 3	Homo sapiens	20-24
31356773-4	2019	Their transport properties and kinetic parameters demonstrate that UCP5 and UCP6 transport inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and (only UCP5) glutamate and tricarboxylates.	Aspartic Acid	266-275	solute carrier family 25 member 14	Homo sapiens	67-71
31151511-8	2019	In vivo imaging demonstrated that ASP-DOCA NPs specifically targeted HepG2 tumors via ASGPR, improving the accumulation of DOX/ASP-DOCA NPs in tumors and generating superior antitumor activity compared with free DOX and DOX/DEX-DOCA NPs.	Aspartic Acid	34-37	asialoglycoprotein receptor 1	Homo sapiens	86-91
31037469-7	2019	We identify two conserved serine residues in Box 2-3 that are phosphorylated in meiosis and whose mutation to aspartate stabilises Csm1-Dsn1 binding, suggesting that regulated phosphorylation of these residues may play a role in sister kinetochore crosslinking specificity.	Aspartic Acid	110-119	MIND complex subunit DSN1	Saccharomyces cerevisiae S288C	136-140
31295752-3	2019	According to in silico analysis, we identified Asp-358 as an integrin alpha6-specific vertebrate-conserved residue and consequently as a potential therapeutic target.	Aspartic Acid	47-50	integrin subunit alpha 6	Homo sapiens	61-76
31295752-4	2019	Because Asp-358 is located on the surface of the beta propeller domain that interacts with other molecules for integrin alpha6 function, we hypothesized that a peptide with the sequence around Asp-358 competitively inhibits integrin alpha6 complex formation.	Aspartic Acid	8-11	integrin subunit alpha 6	Homo sapiens	111-126
31295752-4	2019	Because Asp-358 is located on the surface of the beta propeller domain that interacts with other molecules for integrin alpha6 function, we hypothesized that a peptide with the sequence around Asp-358 competitively inhibits integrin alpha6 complex formation.	Aspartic Acid	8-11	integrin subunit alpha 6	Homo sapiens	224-239
31295752-4	2019	Because Asp-358 is located on the surface of the beta propeller domain that interacts with other molecules for integrin alpha6 function, we hypothesized that a peptide with the sequence around Asp-358 competitively inhibits integrin alpha6 complex formation.	Aspartic Acid	193-196	integrin subunit alpha 6	Homo sapiens	111-126
31295752-4	2019	Because Asp-358 is located on the surface of the beta propeller domain that interacts with other molecules for integrin alpha6 function, we hypothesized that a peptide with the sequence around Asp-358 competitively inhibits integrin alpha6 complex formation.	Aspartic Acid	193-196	integrin subunit alpha 6	Homo sapiens	224-239
31471352-2	2019	The loss of an aspartic acid at position 57 of diabetogenic HLA-DQbeta chains supports this association; this single amino acid change influences how TCRs recognize peptides in the context of HLA-DQ8 and I-Ag7 using a mechanism termed the P9 switch.	Aspartic Acid	15-28	I-ag7	Mus musculus	204-209
31209126-5	2019	The double mutant badc1 badc2 phenocopied wri1-1 with respect to both reduction in root length and elevation of indole-3-acetic acid-Asp levels relative to the wild type.	Aspartic Acid	133-136	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	42-46
31209126-6	2019	Overexpression of BADC1 in wri1-1 decreased indole-3-acetic acid-Asp content and partially rescued its short-root phenotype, demonstrating a role for BADCs in seedling establishment.	Aspartic Acid	65-68	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	27-31
31482121-4	2019	For example, isomerization of aspartic acid into l-isoAsp prevents digestion of the N-terminal portion of Abeta by cathepsin L, one of the most aggressive lysosomal proteases.	Aspartic Acid	30-43	amyloid beta precursor protein	Homo sapiens	106-111
31482121-4	2019	For example, isomerization of aspartic acid into l-isoAsp prevents digestion of the N-terminal portion of Abeta by cathepsin L, one of the most aggressive lysosomal proteases.	Aspartic Acid	30-43	cathepsin L	Homo sapiens	115-126
31482121-9	2019	Although Abeta is known to be isomerized and epimerized in plaques present in AD brains, we further establish that the rates of modification for aspartic acid in positions 1 and 7 are fast and could accrue prior to plaque formation.	Aspartic Acid	145-158	amyloid beta precursor protein	Homo sapiens	9-14
31213525-7	2019	Hydrogen-deuterium exchange MS (HDX-MS) of p38alpha performed at 33, 37, and 39.5  C indicated temperature-dependent conformational changes in an alpha helix near the common docking and glutamate:aspartate substrate-binding domains at the known binding site for MK2.	Aspartic Acid	196-205	mitogen-activated protein kinase 14	Homo sapiens	43-51
31695540-10	2019	Serum HMGB1 levels were positively correlated with aspartate aminotransferase (rs =0.48, p&lt;0.01, Spearman"s rank correlation coefficient) and negatively correlated with fibrinogen (rs = -0.475, p=0.011) and hemoglobin (rs = -0.465, p=0.013).	Aspartic Acid	51-60	high mobility group box 1	Homo sapiens	6-11
31361120-7	2019	The interaction persists in the complex and perturbs a favorable intermolecular salt-bridge contact between R79 in Rab8a and aspartate 187 in Rabin8.	Aspartic Acid	125-134	RAB8A, member RAS oncogene family	Homo sapiens	115-120
31373491-0	2019	Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.	Aspartic Acid	0-9	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	50-70
31373491-5	2019	Here we use protein microarray technology and proteome-wide glycosylation profiling to show that conserved aspartate residues in the tetratricopeptide repeat (TPR) lumen of OGT drive substrate selection.	Aspartic Acid	107-116	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	173-176
31361120-7	2019	The interaction persists in the complex and perturbs a favorable intermolecular salt-bridge contact between R79 in Rab8a and aspartate 187 in Rabin8.	Aspartic Acid	125-134	RAB3A interacting protein	Homo sapiens	142-148
31406120-4	2019	Using a calcium-imaging assay and two-voltage clamp recording, we found that one of the honey bee"s gustatory receptors, AmGr10, functions as a broadly tuned amino acid receptor responding to glutamate, aspartate, asparagine, arginine, lysine, and glutamine, but not to other sweet or bitter compounds.	Aspartic Acid	203-212	gustatory receptor 10	Apis mellifera	121-127
31406120-6	2019	Contact sensory hairs in the mouthpart of the honey bee responded strongly to glutamate and aspartate, which house gustatory receptor neurons expressing AmGr10.	Aspartic Acid	92-101	gustatory receptor 10	Apis mellifera	153-159
31296562-4	2019	ERK2 E-K, like the mutation of the preceding aspartate (ERK2 D321N [D-N]) known as the sevenmaker mutation, causes increased activity in cells and evades inactivation by dual-specificity phosphatases.	Aspartic Acid	45-54	p38a MAP kinase	Drosophila melanogaster	0-4
31358058-7	2019	Our recent study indicates that Casp2-catalyzed tau cleavage at aspartate 314 (tau 2N4R isoform numbering system) mediates synaptotoxicity, cognitive deficits and neurodegeneration in cellular and mouse models of frontotemporal dementia; further, levels of Deltatau314, the soluble, N-terminal cleavage product, are elevated in individuals with mild cognitive impairment and Alzheimer"s disease, compared with cognitively normal individuals.	Aspartic Acid	64-73	caspase 2	Mus musculus	32-37
31358058-7	2019	Our recent study indicates that Casp2-catalyzed tau cleavage at aspartate 314 (tau 2N4R isoform numbering system) mediates synaptotoxicity, cognitive deficits and neurodegeneration in cellular and mouse models of frontotemporal dementia; further, levels of Deltatau314, the soluble, N-terminal cleavage product, are elevated in individuals with mild cognitive impairment and Alzheimer"s disease, compared with cognitively normal individuals.	Aspartic Acid	64-73	microtubule associated protein tau	Homo sapiens	48-51
31358058-7	2019	Our recent study indicates that Casp2-catalyzed tau cleavage at aspartate 314 (tau 2N4R isoform numbering system) mediates synaptotoxicity, cognitive deficits and neurodegeneration in cellular and mouse models of frontotemporal dementia; further, levels of Deltatau314, the soluble, N-terminal cleavage product, are elevated in individuals with mild cognitive impairment and Alzheimer"s disease, compared with cognitively normal individuals.	Aspartic Acid	64-73	microtubule associated protein tau	Homo sapiens	79-82
31173723-4	2019	A molecular docking study was performed based on a constructed model of pig CYP1A2, which predicted the contributions of Thr-118, Thr-124, Phe-125, Phe-226, Leu-260, and Asp-313 to the substrate catalysis.	Aspartic Acid	170-173	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	76-82
31296562-4	2019	ERK2 E-K, like the mutation of the preceding aspartate (ERK2 D321N [D-N]) known as the sevenmaker mutation, causes increased activity in cells and evades inactivation by dual-specificity phosphatases.	Aspartic Acid	45-54	p38a MAP kinase	Drosophila melanogaster	56-60
31101927-3	2019	This study is focused on aspartic acid-to-valine (D166V) mutation in the myosin regulatory light chain, RLC (MYL2 gene), associated with a malignant form of HCM.	Aspartic Acid	25-38	dedicator of cytokinesis 5	Mus musculus	104-107
31357457-5	2019	Another clinical study using a tyrosinase inhibitor L-ascorbate-2-phosphate 3 Na (ASP) demonstrated that L values of test lotion (6% APS)-treated skin significantly increased in SLs and in non-lesional skin with a significantly higher DeltaL value in SLs when compared with non-lesional skin.	Aspartic Acid	82-85	tyrosinase	Homo sapiens	31-41
31152061-4	2019	In this study, using murine skin fibroblasts and HEK293 cells, along with immunoprecipitation, LOX enzymatic activity, solid-phase binding assays, and proteomics analyses, we report that the LOX precursor is proteolytically processed by the procollagen N-proteinases ADAMTS2 and ADAMTS14 between Asp-218 and Tyr-219, 50 amino acids downstream of the BMP1 cleavage site.	Aspartic Acid	296-299	lysyl oxidase	Homo sapiens	191-194
31269432-4	2019	This altered amino acid metabolism in ETR cells is supported by the activation of autophagy and the enhanced import of acidic amino acids (aspartate and glutamate) mediated by the SLC1A2 transporter.	Aspartic Acid	139-148	solute carrier family 1 member 2	Homo sapiens	180-186
31428128-8	2019	Our results indicate that type 2 diabetic patients Asp/Asp homozygotes in the p.Glu936Asp CFH polymorphism are at increased risk of microalbuminuria and cardiovascular complications and may be less likely to benefit from ACEi therapy.	Aspartic Acid	51-54	complement factor H	Homo sapiens	90-93
31428128-8	2019	Our results indicate that type 2 diabetic patients Asp/Asp homozygotes in the p.Glu936Asp CFH polymorphism are at increased risk of microalbuminuria and cardiovascular complications and may be less likely to benefit from ACEi therapy.	Aspartic Acid	55-58	complement factor H	Homo sapiens	90-93
31160337-7	2019	Interestingly, YB-1 CSD forms a homodimer in solution, and we observed that two residues, Tyr-99 and Asp-105, at the dimer interface are important for YB-1 CSD dimerization.	Aspartic Acid	101-104	Y-box binding protein 1	Homo sapiens	15-19
31160337-7	2019	Interestingly, YB-1 CSD forms a homodimer in solution, and we observed that two residues, Tyr-99 and Asp-105, at the dimer interface are important for YB-1 CSD dimerization.	Aspartic Acid	101-104	Y-box binding protein 1	Homo sapiens	151-155
31152065-4	2019	Ddi2 enzymatically hydrates cyanamide to urea and belongs to the family of HD-domain metalloenzymes (named after conserved active-site metal-binding His and Asp residues).	Aspartic Acid	157-160	cyanamide hydratase	Saccharomyces cerevisiae S288C	0-4
31054291-2	2019	For pathogenic orthohantaviruses, integrin beta3 had been previously identified as entry receptor and the presence of aspartic acid residue at position 39 (D39) in human integrin beta3 was described to be a prerequisite for infection of primate cells with Hantaan virus (HTNV).	Aspartic Acid	118-131	integrin subunit beta 3	Homo sapiens	170-184
31101927-3	2019	This study is focused on aspartic acid-to-valine (D166V) mutation in the myosin regulatory light chain, RLC (MYL2 gene), associated with a malignant form of HCM.	Aspartic Acid	25-38	myosin, light polypeptide 2, regulatory, cardiac, slow	Mus musculus	109-113
30981509-6	2019	Further, NRVMs transfected with S282 phospho-mimicking mutant substituted with aspartate or treated with ATP exhibited promotions of Cx43 phosphorylation at S279/282 and intercellular communication.	Aspartic Acid	79-88	gap junction protein, alpha 1	Rattus norvegicus	133-137
31117388-11	2019	Here, we have investigated whether these Asp substitutions would improve the developability potential of a murine antigen binding fragment (Fab).	Aspartic Acid	41-44	FA complementation group B	Homo sapiens	140-143
31117388-12	2019	A full combinatorial library consisting of 393 Fab variants with single, double, and triple Asp substitutions was first screened in silico with Rosetta; thereafter, 26 variants with the highest predicted thermodynamic stability were selected for production.	Aspartic Acid	92-95	FA complementation group B	Homo sapiens	47-50
31125575-6	2019	A systematic mutational analysis of the core MEC motif demonstrated a critical role for the conserved aspartic acid residue at the C-terminus of the MEC motif for binding to both erythrocyte inside-out vesicles and to ANK1.	Aspartic Acid	102-115	ankyrin 1	Homo sapiens	218-222
31253191-8	2019	To therapeutically target the tau-PSR, we bilaterally injected caspase 3-cleaved tau truncated at aspartate 421 (AAV9 Tau DeltaD421) into the hippocampus and cortex of spermidine/spermine-N1-acetyltransferase (SSAT), a key regulator of the tau-PSR, knock out (SSAT-/-), and wild type littermates, and the effects on tau neuropathology, polyamine dysregulation, and behavior were measured.	Aspartic Acid	98-107	caspase 3	Mus musculus	63-72
31235832-7	2019	Next, Ala-scanning of the five Asp residues preceding the activation site Lys revealed that mutation D22A accelerated CTSB-mediated activation by 2-fold.	Aspartic Acid	31-34	cathepsin B	Mus musculus	118-122
31006591-5	2019	Loss of PC depleted aspartate and compromised urea cycle function, causing elevated urea cycle intermediates and hyperammonemia.	Aspartic Acid	20-29	pyruvate carboxylase	Mus musculus	8-10
30910922-4	2019	In this study, we investigated the role of shear stress on active transport of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) by Madin-Darby canine kidney cells exogenously expressing the human organic cation transporters organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).	Aspartic Acid	134-138	solute carrier family 22 member 2	Homo sapiens	266-270
31018661-4	2019	This involves the transcriptional modulator CITED2 (Atypical chemokine receptor 3 CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail) and downstream activation of CXCL12 (chemokine [C-X-C motif] ligand-12) signaling through the CXCR7 (C-X-C chemokine receptor type 7) receptor and ERK1/2 (extracellular signal-regulated kinases 1/2).	Aspartic Acid	141-154	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	44-50
31018661-4	2019	This involves the transcriptional modulator CITED2 (Atypical chemokine receptor 3 CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail) and downstream activation of CXCL12 (chemokine [C-X-C motif] ligand-12) signaling through the CXCR7 (C-X-C chemokine receptor type 7) receptor and ERK1/2 (extracellular signal-regulated kinases 1/2).	Aspartic Acid	141-154	E1A binding protein p300	Homo sapiens	86-90
31018661-4	2019	This involves the transcriptional modulator CITED2 (Atypical chemokine receptor 3 CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail) and downstream activation of CXCL12 (chemokine [C-X-C motif] ligand-12) signaling through the CXCR7 (C-X-C chemokine receptor type 7) receptor and ERK1/2 (extracellular signal-regulated kinases 1/2).	Aspartic Acid	141-154	C-X-C motif chemokine ligand 12	Homo sapiens	199-205
31018661-4	2019	This involves the transcriptional modulator CITED2 (Atypical chemokine receptor 3 CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail) and downstream activation of CXCL12 (chemokine [C-X-C motif] ligand-12) signaling through the CXCR7 (C-X-C chemokine receptor type 7) receptor and ERK1/2 (extracellular signal-regulated kinases 1/2).	Aspartic Acid	141-154	atypical chemokine receptor 3	Homo sapiens	264-269
31018661-4	2019	This involves the transcriptional modulator CITED2 (Atypical chemokine receptor 3 CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail) and downstream activation of CXCL12 (chemokine [C-X-C motif] ligand-12) signaling through the CXCR7 (C-X-C chemokine receptor type 7) receptor and ERK1/2 (extracellular signal-regulated kinases 1/2).	Aspartic Acid	141-154	mitogen-activated protein kinase 3	Homo sapiens	317-323
31018661-4	2019	This involves the transcriptional modulator CITED2 (Atypical chemokine receptor 3 CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail) and downstream activation of CXCL12 (chemokine [C-X-C motif] ligand-12) signaling through the CXCR7 (C-X-C chemokine receptor type 7) receptor and ERK1/2 (extracellular signal-regulated kinases 1/2).	Aspartic Acid	141-154	mitogen-activated protein kinase 1	Homo sapiens	325-367
29737046-4	2019	The RCP used here is based on the alpha-1 sequence of human collagen type I and contains 12 Arg-Gly-Asp motifs.	Aspartic Acid	100-103	CGRP receptor component	Homo sapiens	4-7
29737046-4	2019	The RCP used here is based on the alpha-1 sequence of human collagen type I and contains 12 Arg-Gly-Asp motifs.	Aspartic Acid	100-103	BCL2 related protein A1	Homo sapiens	34-41
30910922-4	2019	In this study, we investigated the role of shear stress on active transport of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) by Madin-Darby canine kidney cells exogenously expressing the human organic cation transporters organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).	Aspartic Acid	134-138	solute carrier family 47 member 1	Homo sapiens	276-315
30910922-4	2019	In this study, we investigated the role of shear stress on active transport of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) by Madin-Darby canine kidney cells exogenously expressing the human organic cation transporters organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).	Aspartic Acid	134-138	solute carrier family 47 member 1	Homo sapiens	317-322
30714651-1	2019	Thioredoxin is a protein that has been used as model system by various computational methods to predict the pKa of aspartate residue Asp26 which is 3.5 units higher than a solvent exposed one (eg, Asp20).	Aspartic Acid	115-124	thioredoxin	Homo sapiens	0-11
31239858-5	2019	First, we found that ASP effectively suppressed the proliferation of the SK-Hep1 and Hep-3B cells but did not cause significant cytotoxicity in normal liver cells (L-O2).	Aspartic Acid	21-24	DNL-type zinc finger	Homo sapiens	76-80
31112866-8	2019	However, HSP60 silencing enhanced mitochondrial functions in glutamine-directed biosynthesis with increased flow in two parts of the TCA cycle: Gln alphaKG OAA Asp and Gln alphaKG ISO acetyl-CoA, resulting in elevated de novo nucleotide synthesis and lipid synthesis.	Aspartic Acid	160-163	heat shock protein family D (Hsp60) member 1	Homo sapiens	9-14
31142640-3	2019	Here, we report that an N6-methyladenosine (m6A)-assisted polyadenylation (m-ASP) pathway ensures transcriptome integrity in Arabidopsis thaliana Efficient m-ASP pathway activity requires the m6A methyltransferase-associated factor FIP37 and CPSF30L, an m6A reader corresponding to an YT512-B Homology Domain-containing protein (YTHDC)-type domain containing isoform of the 30-kD subunit of cleavage and polyadenylation specificity factor.	Aspartic Acid	77-80	FKBP12 interacting protein 37	Arabidopsis thaliana	232-237
31142640-3	2019	Here, we report that an N6-methyladenosine (m6A)-assisted polyadenylation (m-ASP) pathway ensures transcriptome integrity in Arabidopsis thaliana Efficient m-ASP pathway activity requires the m6A methyltransferase-associated factor FIP37 and CPSF30L, an m6A reader corresponding to an YT512-B Homology Domain-containing protein (YTHDC)-type domain containing isoform of the 30-kD subunit of cleavage and polyadenylation specificity factor.	Aspartic Acid	158-161	FKBP12 interacting protein 37	Arabidopsis thaliana	232-237
31142640-4	2019	Targets of the m-ASP pathway are enriched in recently rearranged gene pairs, displayed an atypical chromatin signature, and showed transcriptional readthrough and mRNA chimera formation in FIP37- and CPSF30L-deficient plants.	Aspartic Acid	17-20	FKBP12 interacting protein 37	Arabidopsis thaliana	189-194
31160916-8	2019	Results: The distinct metabolites between PDR and NDR groups were significantly enriched in 9 KEGG pathways (P &lt; 0.05, impact &gt; 0.1), namely, alanine, aspartate and glutamate metabolism, caffeine metabolism, beta-alanine metabolism, purine metabolism, cysteine and methionine metabolism, sulfur metabolism, sphingosine metabolism, and arginine and proline metabolism.	Aspartic Acid	157-166	serine/threonine kinase 38	Homo sapiens	50-53
31239858-6	2019	Then, we found that ASP inhibited the migration and invasion of the SK-Hep1 and Hep-3B cells and HCC cells-induced angiogenesis of human umbilical vein endothelial cells in a concentration-dependent manner.	Aspartic Acid	20-23	DNL-type zinc finger	Homo sapiens	71-75
31239858-7	2019	Mechanistic studies revealed that the inhibition of migration, invasion, and angiogenesis by ASP in the SK-Hep1 and Hep-3B cells might occur via the downregulation of HIF-1alpha/VEGF signalling pathway.	Aspartic Acid	93-96	DNL-type zinc finger	Homo sapiens	107-111
30940649-5	2019	Single-site mutations of aspartate and glutamate residues reveal their role in interactions with ASC-1.	Aspartic Acid	25-34	solute carrier family 7 member 10	Homo sapiens	97-102
31239858-7	2019	Mechanistic studies revealed that the inhibition of migration, invasion, and angiogenesis by ASP in the SK-Hep1 and Hep-3B cells might occur via the downregulation of HIF-1alpha/VEGF signalling pathway.	Aspartic Acid	93-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-177
31239858-7	2019	Mechanistic studies revealed that the inhibition of migration, invasion, and angiogenesis by ASP in the SK-Hep1 and Hep-3B cells might occur via the downregulation of HIF-1alpha/VEGF signalling pathway.	Aspartic Acid	93-96	vascular endothelial growth factor A	Homo sapiens	178-182
31239858-8	2019	Finally, our results also showed that the inhibition of HIF-1alpha by ASP may be mediated through the downregulation of the phosphorylation levels of AKT, mTOR, and ERK.	Aspartic Acid	70-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
31239858-8	2019	Finally, our results also showed that the inhibition of HIF-1alpha by ASP may be mediated through the downregulation of the phosphorylation levels of AKT, mTOR, and ERK.	Aspartic Acid	70-73	AKT serine/threonine kinase 1	Homo sapiens	150-153
31239858-8	2019	Finally, our results also showed that the inhibition of HIF-1alpha by ASP may be mediated through the downregulation of the phosphorylation levels of AKT, mTOR, and ERK.	Aspartic Acid	70-73	mechanistic target of rapamycin kinase	Homo sapiens	155-159
31239858-8	2019	Finally, our results also showed that the inhibition of HIF-1alpha by ASP may be mediated through the downregulation of the phosphorylation levels of AKT, mTOR, and ERK.	Aspartic Acid	70-73	mitogen-activated protein kinase 1	Homo sapiens	165-168
31239858-9	2019	In conclusion, our results suggest that ASP suppresses the migration, invasion, and angiogenesis of HCC cells partly via inhibiting the HIF-1alpha/VEGF signalling pathway.	Aspartic Acid	40-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-146
31239858-9	2019	In conclusion, our results suggest that ASP suppresses the migration, invasion, and angiogenesis of HCC cells partly via inhibiting the HIF-1alpha/VEGF signalling pathway.	Aspartic Acid	40-43	vascular endothelial growth factor A	Homo sapiens	147-151
30858177-2	2019	Substitutions at Asp-109 in the first intracellular loop between the first and second transmembrane domains (TMDs) abolish PCFT function, but protein expression and trafficking to the cell membrane are retained.	Aspartic Acid	17-20	solute carrier family 46 member 1	Homo sapiens	123-127
31117169-4	2019	In addition, we use our engineered CASP3 to characterize the effect of aspartate mutations on enzymatic activity.	Aspartic Acid	71-80	caspase 3	Homo sapiens	35-40
30948508-8	2019	NACA and PP1A cooperatively potentiated cJUN transcriptional activity of the AP-1-responsive MMP9-luciferase reporter, which was abolished when Thr-89, Ser-151, or Thr-174 were substituted with phosphomimetic aspartate residues.	Aspartic Acid	209-218	nascent polypeptide associated complex subunit alpha	Homo sapiens	0-4
30948508-8	2019	NACA and PP1A cooperatively potentiated cJUN transcriptional activity of the AP-1-responsive MMP9-luciferase reporter, which was abolished when Thr-89, Ser-151, or Thr-174 were substituted with phosphomimetic aspartate residues.	Aspartic Acid	209-218	protein phosphatase 1 catalytic subunit alpha	Homo sapiens	9-13
30948508-8	2019	NACA and PP1A cooperatively potentiated cJUN transcriptional activity of the AP-1-responsive MMP9-luciferase reporter, which was abolished when Thr-89, Ser-151, or Thr-174 were substituted with phosphomimetic aspartate residues.	Aspartic Acid	209-218	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-44
30948508-8	2019	NACA and PP1A cooperatively potentiated cJUN transcriptional activity of the AP-1-responsive MMP9-luciferase reporter, which was abolished when Thr-89, Ser-151, or Thr-174 were substituted with phosphomimetic aspartate residues.	Aspartic Acid	209-218	matrix metallopeptidase 9	Homo sapiens	93-97
30902848-7	2019	By engineering a novel Gsdmd D88A knock-in mouse, we further demonstrate that this proinflammatory function of caspase-8 is counteracted by caspase-3-dependent cleavage and inactivation of GSDMD at aspartate 88, and is essential to suppress GSDMD-dependent cell lysis during caspase-8-dependent apoptosis.	Aspartic Acid	198-207	gasdermin D	Mus musculus	23-28
30902848-7	2019	By engineering a novel Gsdmd D88A knock-in mouse, we further demonstrate that this proinflammatory function of caspase-8 is counteracted by caspase-3-dependent cleavage and inactivation of GSDMD at aspartate 88, and is essential to suppress GSDMD-dependent cell lysis during caspase-8-dependent apoptosis.	Aspartic Acid	198-207	caspase 8	Mus musculus	111-120
30902848-7	2019	By engineering a novel Gsdmd D88A knock-in mouse, we further demonstrate that this proinflammatory function of caspase-8 is counteracted by caspase-3-dependent cleavage and inactivation of GSDMD at aspartate 88, and is essential to suppress GSDMD-dependent cell lysis during caspase-8-dependent apoptosis.	Aspartic Acid	198-207	caspase 3	Mus musculus	140-149
30902848-7	2019	By engineering a novel Gsdmd D88A knock-in mouse, we further demonstrate that this proinflammatory function of caspase-8 is counteracted by caspase-3-dependent cleavage and inactivation of GSDMD at aspartate 88, and is essential to suppress GSDMD-dependent cell lysis during caspase-8-dependent apoptosis.	Aspartic Acid	198-207	gasdermin D	Mus musculus	189-194
31068217-3	2019	Binding to KLC1/2 involves a C-terminal tryptophan/aspartate (WD) motif in LMTK2 and the tetratricopeptide repeat (TPR) domains in KLC1/2, and this interaction facilitates axonal transport of LMTK2.	Aspartic Acid	51-60	kinesin light chain 1	Homo sapiens	11-17
31068217-3	2019	Binding to KLC1/2 involves a C-terminal tryptophan/aspartate (WD) motif in LMTK2 and the tetratricopeptide repeat (TPR) domains in KLC1/2, and this interaction facilitates axonal transport of LMTK2.	Aspartic Acid	51-60	lemur tyrosine kinase 2	Homo sapiens	75-80
31068217-3	2019	Binding to KLC1/2 involves a C-terminal tryptophan/aspartate (WD) motif in LMTK2 and the tetratricopeptide repeat (TPR) domains in KLC1/2, and this interaction facilitates axonal transport of LMTK2.	Aspartic Acid	51-60	lemur tyrosine kinase 2	Homo sapiens	192-197
31091247-10	2019	ROC analyses revealed a significant separation between RL and NRL for ASP after 4 months (AUC 0.85, p&lt;0.001) and after 12 months (AUC 0.94, p&lt;0.001).	Aspartic Acid	70-73	neural retina leucine zipper	Homo sapiens	62-65
30808704-6	2019	Since Bnl signaling levels feedback control cytoneme production in the ASP, the reduced availability of mutant Bnl on the source basal surface decreases ASP cytoneme numbers, leading to a reduced range of signal/signaling gradient and impaired ASP growth.	Aspartic Acid	71-74	branchless	Drosophila melanogaster	6-9
30808704-6	2019	Since Bnl signaling levels feedback control cytoneme production in the ASP, the reduced availability of mutant Bnl on the source basal surface decreases ASP cytoneme numbers, leading to a reduced range of signal/signaling gradient and impaired ASP growth.	Aspartic Acid	71-74	branchless	Drosophila melanogaster	111-114
30808704-6	2019	Since Bnl signaling levels feedback control cytoneme production in the ASP, the reduced availability of mutant Bnl on the source basal surface decreases ASP cytoneme numbers, leading to a reduced range of signal/signaling gradient and impaired ASP growth.	Aspartic Acid	153-156	branchless	Drosophila melanogaster	111-114
30858177-7	2019	Substitutions at Asp-109 and Gly-112 lock PCFT in an inward-open conformation, resulting in the loss of function.	Aspartic Acid	17-20	solute carrier family 46 member 1	Homo sapiens	42-46
31234761-2	2019	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), also known as L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (PCMT), methylates covalently modified isoaspartate (isoAsp) residues accumulated in proteins via Asn deamidation and Asp hydrolysis.	Aspartic Acid	195-198	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	0-56
31234761-2	2019	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), also known as L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (PCMT), methylates covalently modified isoaspartate (isoAsp) residues accumulated in proteins via Asn deamidation and Asp hydrolysis.	Aspartic Acid	195-198	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	58-62
31234761-2	2019	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), also known as L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (PCMT), methylates covalently modified isoaspartate (isoAsp) residues accumulated in proteins via Asn deamidation and Asp hydrolysis.	Aspartic Acid	195-198	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	104-138
31234761-2	2019	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), also known as L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (PCMT), methylates covalently modified isoaspartate (isoAsp) residues accumulated in proteins via Asn deamidation and Asp hydrolysis.	Aspartic Acid	195-198	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	140-144
31234761-5	2019	PIMT transforms isoAsp into succinimide, thereby creating an opportunity for the later to be converted into Asp.	Aspartic Acid	19-22	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	0-4
31127439-6	2019	Linear dynamic range and limit of detection for aspartic acid were 0.5-50 muM and 90 nM, respectively.	Aspartic Acid	48-61	latexin	Homo sapiens	74-77
30889508-7	2019	EMSA analysis of PrimPol:ssDNA:dNTP pre-ternary complex indicated a critical role of each metal ligand, and a significant impairment when Glu116 was changed to a more conventional aspartate.	Aspartic Acid	180-189	primase and DNA directed polymerase	Homo sapiens	17-24
30287925-6	2019	CONCLUSION: MEPE exerts its function in bone homeostasis by two domains, an RGD and an acidic serine aspartate-rich MEPE-associated (ASARM) motif inhibiting respectively bone resorption and mineralization.	Aspartic Acid	101-110	matrix extracellular phosphoglycoprotein	Homo sapiens	12-16
30287925-6	2019	CONCLUSION: MEPE exerts its function in bone homeostasis by two domains, an RGD and an acidic serine aspartate-rich MEPE-associated (ASARM) motif inhibiting respectively bone resorption and mineralization.	Aspartic Acid	101-110	matrix extracellular phosphoglycoprotein	Homo sapiens	116-120
30807804-3	2019	The tPA-loaded liposomes were PEGylated to improve their stability, and surface coated with a conformationally-constrained, cyclic arginine-glycine-aspartic acid (cRGD) to enable highly selective binding to activated platelets.	Aspartic Acid	148-161	chromosome 20 open reading frame 181	Homo sapiens	4-7
30782965-4	2019	The surface-exposed Asp (D287) residue of BAK1 is critical for its proteolytic cleavage and plays an essential role in BAK1-regulated plant immunity, growth hormone brassinosteroid-mediated responses, and cell death containment.	Aspartic Acid	20-23	BRI1-associated receptor kinase	Arabidopsis thaliana	42-46
30782965-4	2019	The surface-exposed Asp (D287) residue of BAK1 is critical for its proteolytic cleavage and plays an essential role in BAK1-regulated plant immunity, growth hormone brassinosteroid-mediated responses, and cell death containment.	Aspartic Acid	20-23	BRI1-associated receptor kinase	Arabidopsis thaliana	119-123
30770653-2	2019	In this study, a vascular endothelial growth factor (VEGF165) and angiopoietin-1 (Ang-1) dual gene coexpression vector that encoded green fluorescent protein (GFP) was constructed from an arginine-glycine-aspartic acid-modified adenovirus.	Aspartic Acid	205-218	vascular endothelial growth factor A	Homo sapiens	17-51
30770653-2	2019	In this study, a vascular endothelial growth factor (VEGF165) and angiopoietin-1 (Ang-1) dual gene coexpression vector that encoded green fluorescent protein (GFP) was constructed from an arginine-glycine-aspartic acid-modified adenovirus.	Aspartic Acid	205-218	angiopoietin 1	Homo sapiens	66-80
30770653-2	2019	In this study, a vascular endothelial growth factor (VEGF165) and angiopoietin-1 (Ang-1) dual gene coexpression vector that encoded green fluorescent protein (GFP) was constructed from an arginine-glycine-aspartic acid-modified adenovirus.	Aspartic Acid	205-218	angiopoietin 1	Homo sapiens	82-87
30770653-7	2019	In conclusion, SF scaffolds loaded with arginine-glycine-aspartic acid-modified adenovirus vectors encoding VEGF165 and Ang-1 could stimulate the formation of vascular networks through the effective expression of target genes in vascular endothelial cells, thereby accelerating the regeneration of dermal tissue.	Aspartic Acid	57-70	angiopoietin 1	Homo sapiens	120-125
31133770-4	2019	In addition, substitution of the proximal histidine with an aspartate residue led to a myoglobin-based catalyst capable of promoting stereoselective olefin cyclopropanation under nonreducing conditions.	Aspartic Acid	60-69	myoglobin	Homo sapiens	87-96
30854626-4	2019	We find that JAK/STAT signaling occurs in ASP tip cells and misexpression of core components in the JAK/STAT signaling cascade significantly impedes ASP development.	Aspartic Acid	42-45	hopscotch	Drosophila melanogaster	13-16
30995827-3	2019	The human SLC25A13 gene, encoding for the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), catalyses the electrogenic exchange of aspartate for glutamate plus a proton, thus taking part in many metabolic processes including the malate-aspartate shuttle.	Aspartic Acid	56-65	solute carrier family 25 member 13	Homo sapiens	10-18
30995827-3	2019	The human SLC25A13 gene, encoding for the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), catalyses the electrogenic exchange of aspartate for glutamate plus a proton, thus taking part in many metabolic processes including the malate-aspartate shuttle.	Aspartic Acid	141-150	solute carrier family 25 member 13	Homo sapiens	10-18
30742966-3	2019	Using cross-species sequence comparison, we show that an aspartate in position 132 (D132), located within the conserved nuclear localization signal (NLS) of FMRP, appears in human and other mammals, while glutamate 132 (E132) appears in rodents and birds.	Aspartic Acid	57-66	fragile X messenger ribonucleoprotein 1	Homo sapiens	157-161
30988455-3	2019	Of the 103 metabolites accurately measured, univariate analysis including the Benjamini-Hochberg correction revealed 6 significantly different metabolites in OPA1 down-regulated neurons, with aspartate being the most significant (p < 0.001).	Aspartic Acid	192-201	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	158-162
30988455-5	2019	Amongst the 46 metabolites contributing the most to the metabolic signature were aspartate, glutamate and threonine, which all decreased in OPA1 down-regulated neurons, and lysine, 4 sphingomyelins, 4 lysophosphatidylcholines and 32 phosphatidylcholines which were increased.	Aspartic Acid	81-90	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	140-144
30988455-7	2019	Aspartate and glutamate deficiency, also found in the plasma of OPA1 patients, is likely the consequence of respiratory chain deficiency, whereas the glutamate decrease could contribute to the synaptic dysfunction that we previously identified in this model.	Aspartic Acid	0-9	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	64-68
30721696-5	2019	How an aspartic acid would affect catalysis was studied by replacing Cys-153 in Saccharomyces cerevisiae ADH1 by using site-directed mutagenesis.	Aspartic Acid	7-20	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	105-109
31002798-3	2019	Here, we show that the PNG-1/NGLY1 peptide:N-glycanase edits the sequence of SKN-1A protein by converting particular N-glycosylated asparagine residues to aspartic acid.	Aspartic Acid	155-168	N-glycanase 1	Homo sapiens	23-28
31002798-3	2019	Here, we show that the PNG-1/NGLY1 peptide:N-glycanase edits the sequence of SKN-1A protein by converting particular N-glycosylated asparagine residues to aspartic acid.	Aspartic Acid	155-168	N-glycanase 1	Homo sapiens	29-34
31002798-3	2019	Here, we show that the PNG-1/NGLY1 peptide:N-glycanase edits the sequence of SKN-1A protein by converting particular N-glycosylated asparagine residues to aspartic acid.	Aspartic Acid	155-168	N-glycanase 1	Homo sapiens	35-54
31002798-3	2019	Here, we show that the PNG-1/NGLY1 peptide:N-glycanase edits the sequence of SKN-1A protein by converting particular N-glycosylated asparagine residues to aspartic acid.	Aspartic Acid	155-168	POU class 2 homeobox 3	Homo sapiens	77-83
31002798-4	2019	Genetically introducing aspartates at these N-glycosylation sites bypasses the requirement for PNG-1/NGLY1, showing that protein sequence editing rather than deglycosylation is key to SKN-1A function.	Aspartic Acid	24-34	N-glycanase 1	Homo sapiens	95-100
31002798-4	2019	Genetically introducing aspartates at these N-glycosylation sites bypasses the requirement for PNG-1/NGLY1, showing that protein sequence editing rather than deglycosylation is key to SKN-1A function.	Aspartic Acid	24-34	N-glycanase 1	Homo sapiens	101-106
31002798-4	2019	Genetically introducing aspartates at these N-glycosylation sites bypasses the requirement for PNG-1/NGLY1, showing that protein sequence editing rather than deglycosylation is key to SKN-1A function.	Aspartic Acid	24-34	POU class 2 homeobox 3	Homo sapiens	184-190
30684458-7	2019	Based on binding complementation of mutant ligands towards mutant receptors, we deduced possible electrostatic interactions of the agonist and antagonist with both RXFP3 and RXFP4: their B-chain C-terminal Arg residue interacts with the deeply buried Glu residue in the WxxExxxD motif of both receptors, and one or two of their B-chain central Arg residues interact with the shallowly buried Asp residue in the WxxExxxD motif of both receptors.	Aspartic Acid	392-395	relaxin family peptide receptor 3	Homo sapiens	164-169
30684458-7	2019	Based on binding complementation of mutant ligands towards mutant receptors, we deduced possible electrostatic interactions of the agonist and antagonist with both RXFP3 and RXFP4: their B-chain C-terminal Arg residue interacts with the deeply buried Glu residue in the WxxExxxD motif of both receptors, and one or two of their B-chain central Arg residues interact with the shallowly buried Asp residue in the WxxExxxD motif of both receptors.	Aspartic Acid	392-395	relaxin family peptide/INSL5 receptor 4	Homo sapiens	174-179
30854626-4	2019	We find that JAK/STAT signaling occurs in ASP tip cells and misexpression of core components in the JAK/STAT signaling cascade significantly impedes ASP development.	Aspartic Acid	42-45	Signal-transducer and activator of transcription protein at 92E	Drosophila melanogaster	17-21
30854626-4	2019	We find that JAK/STAT signaling occurs in ASP tip cells and misexpression of core components in the JAK/STAT signaling cascade significantly impedes ASP development.	Aspartic Acid	42-45	Signal-transducer and activator of transcription protein at 92E	Drosophila melanogaster	104-108
30854626-5	2019	We further identify Upd2 as an activating ligand for JAK/STAT activity in the ASP.	Aspartic Acid	78-81	unpaired 2	Drosophila melanogaster	20-24
30854626-5	2019	We further identify Upd2 as an activating ligand for JAK/STAT activity in the ASP.	Aspartic Acid	78-81	hopscotch	Drosophila melanogaster	53-56
30854626-5	2019	We further identify Upd2 as an activating ligand for JAK/STAT activity in the ASP.	Aspartic Acid	78-81	Signal-transducer and activator of transcription protein at 92E	Drosophila melanogaster	57-61
30714292-0	2019	Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.	Aspartic Acid	93-102	BRCA1 DNA repair associated	Homo sapiens	11-16
30783866-8	2019	Arg or Asp was identified as a catalytic site in plasmodium IspD homologs, contributing a direct role in the cytidylyltransferase activity similar to bacterial IspD.	Aspartic Acid	7-10	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	60-64
30783866-8	2019	Arg or Asp was identified as a catalytic site in plasmodium IspD homologs, contributing a direct role in the cytidylyltransferase activity similar to bacterial IspD.	Aspartic Acid	7-10	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	160-164
30320908-4	2019	We observed an increase in aspartate and alanine, together with a decrease in arginine levels, on overexpression of NSD3s or Pdp3, suggesting an increase in the rate of glutaminolysis.	Aspartic Acid	27-36	Pdp3p	Saccharomyces cerevisiae S288C	125-129
30714292-0	2019	Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.	Aspartic Acid	93-102	zinc finger protein 350	Homo sapiens	17-22
30714292-0	2019	Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.	Aspartic Acid	93-102	glutamic-oxaloacetic transaminase 2	Homo sapiens	56-60
30714292-3	2019	Here, we identified several metabolic genes, including the gene which encodes glutamate-oxaloacetate transaminase 2 (GOT2), a key enzyme for aspartate biosynthesis, which are repressed by BRCA1.	Aspartic Acid	141-150	glutamic-oxaloacetic transaminase 2	Homo sapiens	78-115
30714292-3	2019	Here, we identified several metabolic genes, including the gene which encodes glutamate-oxaloacetate transaminase 2 (GOT2), a key enzyme for aspartate biosynthesis, which are repressed by BRCA1.	Aspartic Acid	141-150	glutamic-oxaloacetic transaminase 2	Homo sapiens	117-121
30714292-3	2019	Here, we identified several metabolic genes, including the gene which encodes glutamate-oxaloacetate transaminase 2 (GOT2), a key enzyme for aspartate biosynthesis, which are repressed by BRCA1.	Aspartic Acid	141-150	BRCA1 DNA repair associated	Homo sapiens	188-193
30714292-5	2019	Impairment of this complex results in upregulation of GOT2, which in turn increases aspartate and alpha ketoglutarate production, leading to rapid cell proliferation of breast cancer cells.	Aspartic Acid	84-93	glutamic-oxaloacetic transaminase 2	Homo sapiens	54-58
30714292-8	2019	In summary, our findings reveal that BRCA1 modulates aspartate biosynthesis through transcriptional repression of GOT2, and provides a biological basis for treatment choices in breast cancer.	Aspartic Acid	53-62	BRCA1 DNA repair associated	Homo sapiens	37-42
30714292-8	2019	In summary, our findings reveal that BRCA1 modulates aspartate biosynthesis through transcriptional repression of GOT2, and provides a biological basis for treatment choices in breast cancer.	Aspartic Acid	53-62	glutamic-oxaloacetic transaminase 2	Homo sapiens	114-118
32254804-4	2019	The gold nanostars were further designed to be multifunctional nanoagents by labeling Raman molecules and then conjugating arginine-glycine-aspartic acid (RGD), which can serve as cancer cell-targeted SERS-imaging tags and photothermal nanoagents in both the NIR-I and NIR-II windows.	Aspartic Acid	140-153	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	201-205
30733149-5	2019	DII mutants regain CDI by placing an aspartate at the analogous SF site in DIII or DIV, but not DI, indicating that CaV SF asymmetry is key to CDI.	Aspartic Acid	37-46	caveolin 2	Homo sapiens	116-119
30923994-3	2019	Here, we investigated the characters of inactivation by L-aspartate of PanD from Corynebacterium jeikeium (PDCjei), and found that L-aspartate induced a time-, and concentration-dependent inactivation of PDCjei with the values of KI and kinact being 288.4 mM and 0.235/min, respectively.	Aspartic Acid	56-67	aspartate 1-decarboxylase	Corynebacterium jeikeium K411	71-75
30923994-3	2019	Here, we investigated the characters of inactivation by L-aspartate of PanD from Corynebacterium jeikeium (PDCjei), and found that L-aspartate induced a time-, and concentration-dependent inactivation of PDCjei with the values of KI and kinact being 288.4 mM and 0.235/min, respectively.	Aspartic Acid	131-142	aspartate 1-decarboxylase	Corynebacterium jeikeium K411	71-75
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Aspartic Acid	210-219	carnosine dipeptidase 2	Homo sapiens	65-69
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Aspartic Acid	210-219	cathepsin D	Homo sapiens	79-83
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Aspartic Acid	210-219	carnosine dipeptidase 2	Homo sapiens	140-144
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Aspartic Acid	210-219	cathepsin D	Homo sapiens	195-199
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Aspartic Acid	210-219	cathepsin D	Homo sapiens	195-199
30918657-5	2019	Two missense mutation in the exon region of the caprine CIITA gene resulted in replacement of arginine with cysteine at position 9473550 (R9473550C) and aspartic acid with glutamic acid at position 9473870 (D9473870E).	Aspartic Acid	153-166	MHC class II transactivator	Capra hircus	56-61
30655288-6	2019	Unlike the canonical PIP box of p68, the PIP box of p12 lacks the conserved glutamine; binds through a 2-fork plug made of an isoleucine and a tyrosine residue at +3 and +8 positions, respectively; and is stabilized by an aspartate at +6 position, which creates a network of intramolecular hydrogen bonds.	Aspartic Acid	222-231	DNA polymerase delta 4, accessory subunit	Homo sapiens	52-55
30390369-5	2019	We have previously demonstrated the unique conjugation between the dihydrolipoamide dehydrogenase (DLDH) protein and TiO2 surfaces, based on specific coordinative bonding via Cys-His-Glu-Asp motif residues.	Aspartic Acid	187-190	dihydrolipoamide dehydrogenase	Homo sapiens	67-97
31372400-2	2019	The article provides data to show that Dictyostelium Sestrin share conserved amino acid residues, cysteine and aspartic acid with human Sestrin2.	Aspartic Acid	111-124	sestrin 2	Homo sapiens	136-144
30862943-0	2019	Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model.	Aspartic Acid	28-37	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	66-109
30862943-0	2019	Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model.	Aspartic Acid	28-37	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	111-117
30595160-3	2019	Aspartate N-acetyltransferase (Asp-NAT, encoded by Nat8l) synthesizes NAA from acetyl-CoA and aspartate and increases energy expenditure in brown adipocytes.	Aspartic Acid	94-103	N-acetyltransferase 8 like	Homo sapiens	51-56
30529011-7	2019	The SIBLING, matrix extracellular phosphoglycoprotein with ASARM motif (MEPE) is highly overexpressed in both BSP-/- and DKO and may impair mineralization through liberation of its ASARM (Acidic Serine-Aspartate Rich MEPE associated) peptides.	Aspartic Acid	202-211	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	Mus musculus	72-76
30529011-7	2019	The SIBLING, matrix extracellular phosphoglycoprotein with ASARM motif (MEPE) is highly overexpressed in both BSP-/- and DKO and may impair mineralization through liberation of its ASARM (Acidic Serine-Aspartate Rich MEPE associated) peptides.	Aspartic Acid	202-211	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	Mus musculus	217-221
30423259-5	2019	In particular, we have previously shown that caspase cleavage of mutant HTT at amino acid position aspartate 586 (D586) by caspase-6 is critical for the pathogenesis of the disease in an HD mouse model.	Aspartic Acid	99-108	caspase 1	Mus musculus	45-52
30423259-5	2019	In particular, we have previously shown that caspase cleavage of mutant HTT at amino acid position aspartate 586 (D586) by caspase-6 is critical for the pathogenesis of the disease in an HD mouse model.	Aspartic Acid	99-108	huntingtin	Mus musculus	72-75
30423259-5	2019	In particular, we have previously shown that caspase cleavage of mutant HTT at amino acid position aspartate 586 (D586) by caspase-6 is critical for the pathogenesis of the disease in an HD mouse model.	Aspartic Acid	99-108	caspase 6	Mus musculus	123-132
30390369-5	2019	We have previously demonstrated the unique conjugation between the dihydrolipoamide dehydrogenase (DLDH) protein and TiO2 surfaces, based on specific coordinative bonding via Cys-His-Glu-Asp motif residues.	Aspartic Acid	187-190	dihydrolipoamide dehydrogenase	Homo sapiens	99-103
31353561-7	2019	PRACTICAL APPLICATIONS: L-asparaginase (L-asparagine amidohydrolase; EC 3.5.1.1) is an enzyme that catalyzes the hydrolysis of the amide group of the side-chain of L-asparagine into aspartic acid and ammonia.	Aspartic Acid	182-195	L-asparaginase	Glycine max	40-67
30461096-8	2019	This approach was applied to Src mutant libraries randomized in the highly conserved HRD motif in the catalytic loop, and revealed that structurally diverse residues can replace the His and Arg residues, while the Asp residue is irreplaceable for catalytic activity.	Aspartic Acid	214-217	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	29-32
30617148-4	2019	Here, we found that substitution of Asp at position 172 in the linker between the LR4 and LR5 of full-length LDLR with Asn (D172N) reduced PCSK9 binding at pH 7.4 (mimic cell surface), but not at pH 6.0 (mimic endosomal environment).	Aspartic Acid	36-39	low density lipoprotein receptor	Homo sapiens	109-113
30617148-4	2019	Here, we found that substitution of Asp at position 172 in the linker between the LR4 and LR5 of full-length LDLR with Asn (D172N) reduced PCSK9 binding at pH 7.4 (mimic cell surface), but not at pH 6.0 (mimic endosomal environment).	Aspartic Acid	36-39	proprotein convertase subtilisin/kexin type 9	Homo sapiens	139-144
30617148-5	2019	On the other hand, mutation of Asp at position 203 in the LR5 of full-length LDLR to Asn (D203N) significantly reduced PCSK9 binding at both pH 7.4 and pH 6.0.	Aspartic Acid	31-34	low density lipoprotein receptor	Homo sapiens	77-81
30617148-5	2019	On the other hand, mutation of Asp at position 203 in the LR5 of full-length LDLR to Asn (D203N) significantly reduced PCSK9 binding at both pH 7.4 and pH 6.0.	Aspartic Acid	31-34	proprotein convertase subtilisin/kexin type 9	Homo sapiens	119-124
30688831-4	2019	MATERIALS AND METHODS: We evaluated the insulin-induced chemoresistance and AKT pathway activation by measuring cell proliferation, apoptosis, and other parameters in ALL cell lines (Jurkat and Reh cells), as well as in primary pediatric leukemic cell samples, after culture with insulin, the chemotherapeutic drugs daunorubicin (DNR), vincristine (VCR), and L-asparaginase (L-Asp), or anti-insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibody.	Aspartic Acid	377-380	insulin	Homo sapiens	40-47
30819957-3	2019	Dpp signaling in the ASP was compromised if disc cells lacked Synaptobrevin and Synaptotagmin-1 (which function in vesicle transport at neuronal synapses), the glutamate transporter, and a voltage-gated calcium channel, or if ASP cells lacked Synaptotagmin-4 or the glutamate receptor GluRII.	Aspartic Acid	21-24	Synaptobrevin	Drosophila melanogaster	62-75
30819957-3	2019	Dpp signaling in the ASP was compromised if disc cells lacked Synaptobrevin and Synaptotagmin-1 (which function in vesicle transport at neuronal synapses), the glutamate transporter, and a voltage-gated calcium channel, or if ASP cells lacked Synaptotagmin-4 or the glutamate receptor GluRII.	Aspartic Acid	21-24	Synaptotagmin 4	Drosophila melanogaster	243-258
30819957-3	2019	Dpp signaling in the ASP was compromised if disc cells lacked Synaptobrevin and Synaptotagmin-1 (which function in vesicle transport at neuronal synapses), the glutamate transporter, and a voltage-gated calcium channel, or if ASP cells lacked Synaptotagmin-4 or the glutamate receptor GluRII.	Aspartic Acid	21-24	Glutamate receptor IIA	Drosophila melanogaster	285-291
30572191-6	2019	Obtained results showed that the UA could increase amount of doxorubicin (Dox) entering the cell to accumulate in nuclei, decrease the efflux ratio of digoxin comparable to the effects of the known inhibitor verapamil by acting as a P-gp substrate, decrease the content of intracellular alanine, lactate, pyruvate, glucose, alpha-ketoglutarate, glutamate, glutamine, aspartate, serine, and glycine.	Aspartic Acid	367-376	ATP binding cassette subfamily B member 1	Homo sapiens	233-237
30811976-0	2019	HIF1alpha Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.	Aspartic Acid	68-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
30811976-3	2019	Here, we discovered that HIF1alpha acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (GOT1) and mitochondrial GOT2.	Aspartic Acid	65-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-34
30811976-3	2019	Here, we discovered that HIF1alpha acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (GOT1) and mitochondrial GOT2.	Aspartic Acid	65-74	glutamic-oxaloacetic transaminase 1	Homo sapiens	179-214
30811976-3	2019	Here, we discovered that HIF1alpha acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (GOT1) and mitochondrial GOT2.	Aspartic Acid	65-74	glutamic-oxaloacetic transaminase 1	Homo sapiens	216-220
30811976-3	2019	Here, we discovered that HIF1alpha acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (GOT1) and mitochondrial GOT2.	Aspartic Acid	65-74	glutamic-oxaloacetic transaminase 2	Homo sapiens	240-244
30811976-3	2019	Here, we discovered that HIF1alpha acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (GOT1) and mitochondrial GOT2.	Aspartic Acid	129-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-34
30811976-3	2019	Here, we discovered that HIF1alpha acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (GOT1) and mitochondrial GOT2.	Aspartic Acid	129-138	glutamic-oxaloacetic transaminase 1	Homo sapiens	216-220
30811976-3	2019	Here, we discovered that HIF1alpha acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (GOT1) and mitochondrial GOT2.	Aspartic Acid	129-138	glutamic-oxaloacetic transaminase 2	Homo sapiens	240-244
30811976-4	2019	Accordingly, HIF1alpha suppresses aspartate production from both glutamine oxidation as well as the glutamine reductive pathway.	Aspartic Acid	34-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-22
30811976-5	2019	Strikingly, the addition of aspartate to the culture medium is sufficient to relieve HIF1alpha-dependent repression of tumor cell proliferation.	Aspartic Acid	28-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-94
30811976-6	2019	Furthermore, these key aspartate-producing players are specifically repressed in VHL-deficient human renal carcinomas, a paradigmatic tumor type in which HIF1alpha acts as a tumor suppressor, highlighting the in vivo relevance of these findings.	Aspartic Acid	23-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-163
30811976-7	2019	In conclusion, we show that HIF1alpha inhibits cytosolic and mitochondrial aspartate biosynthesis and that this mechanism is the molecular basis for HIF1alpha tumor suppressor activity.	Aspartic Acid	75-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-37
30811976-7	2019	In conclusion, we show that HIF1alpha inhibits cytosolic and mitochondrial aspartate biosynthesis and that this mechanism is the molecular basis for HIF1alpha tumor suppressor activity.	Aspartic Acid	75-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-158
30863716-5	2019	The interactive binding site residues of H1R are found to be; Lys-191, Tyr-108, Asp-107, Tyr-100, Lys-179, Lys-191, Thr-194, Trp-428, Phe-432, Tyr-458, Hie-450, with most of these shown to be inhibited by naturally-occurring compound curcumin.	Aspartic Acid	80-83	histamine receptor H1	Homo sapiens	41-44
30729243-0	2019	Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles.	Aspartic Acid	23-32	C-X-C motif chemokine receptor 4	Homo sapiens	39-44
30729243-3	2019	Recently synthesised and structurally characterised Co2+/Co3+ and Ni2+ acetate complexes of mono-macrocycle cross-bridged ligands have been used to mimic their known coordination interaction with the aspartate side chains on binding to CXCR4.	Aspartic Acid	200-209	C-X-C motif chemokine receptor 4	Homo sapiens	236-241
30455352-1	2019	Hsp70 chaperones are central hubs of the protein quality control network and collaborate with co-chaperones having a J-domain (an ~70-residue-long helical hairpin with a flexible loop and a conserved His-Pro-Asp motif required for ATP hydrolysis by Hsp70s) and also with nucleotide exchange factors to facilitate many protein-folding processes that (re)establish protein homeostasis.	Aspartic Acid	208-211	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
30591552-3	2019	Molecular simulations showed that Ser-6 in Pep8 forms a hydrogen bond with Asp-202 in eIF4E.	Aspartic Acid	75-78	eukaryotic translation initiation factor 4E	Homo sapiens	86-91
30778083-2	2019	Over half of all PDGFRA mutations are represented by the substitution at position 842 in the A-loop of an aspartic acid (D) with a valine (V), recognized as D842V, conferring primary resistance to imatinib in vitro and in clinical observations due to the conformation of the kinase domain, which negatively affects imatinib binding.	Aspartic Acid	106-119	platelet derived growth factor receptor alpha	Homo sapiens	17-23
30648708-4	2019	A combined study using potentiometric and spectroscopic (UV-Vis, CD, EPR and NMR) techniques indicates the formation of the wanted major species, [CuH(ONMe-Asp)]2+, where copper(ii) is bound to His4(Nepsilon), His7(Nepsilon), His9(Nepsilon) and Asp2(COO-).	Aspartic Acid	156-159	beta-secretase 1	Homo sapiens	245-249
30635421-3	2019	The C-terminal region of LRRK2 is a Trp-Asp-40 (WD40) domain with poorly defined biological functions but has been implicated in microtubule interaction.	Aspartic Acid	40-43	leucine rich repeat kinase 2	Homo sapiens	25-30
30476558-1	2019	GnRH receptor mutations, Glu2.53(90)Lys and Glu2.53(90)Asp, cause congenital hypogonadotropic hypogonadism.	Aspartic Acid	55-58	gonadotropin releasing hormone receptor	Homo sapiens	0-13
30476558-6	2019	Models showed that congenital Glu2.53(90)Lys and Glu2.53(90)Asp mutations disrupt interactions with Ser3.35(124) and Trp6.48(280) respectively, whereas the Glu2.53(90)Arg and Trp6.48(280)Arg mutations preserve intramolecular contacts, but increase distance between the transmembrane helices.	Aspartic Acid	60-63	transient receptor potential cation channel subfamily C member 6	Homo sapiens	117-121
30476558-6	2019	Models showed that congenital Glu2.53(90)Lys and Glu2.53(90)Asp mutations disrupt interactions with Ser3.35(124) and Trp6.48(280) respectively, whereas the Glu2.53(90)Arg and Trp6.48(280)Arg mutations preserve intramolecular contacts, but increase distance between the transmembrane helices.	Aspartic Acid	60-63	transient receptor potential cation channel subfamily C member 6	Homo sapiens	175-179
30573518-2	2019	We have previously shown that in normoxic conditions, ASS1 downregulation facilitates cancer cell proliferation by increasing aspartate availability for pyrimidine synthesis by the enzyme complex CAD.	Aspartic Acid	126-135	argininosuccinate synthase 1	Homo sapiens	54-58
30639924-7	2019	These observations highlighted the importance of residues 67 (Asn in CA II, Gln in CA IX) and 130 (Asp in CA II, Arg in CA IX) in selective CA inhibitor targeting.	Aspartic Acid	99-102	carbonic anhydrase 2	Homo sapiens	106-111
30361942-4	2019	Chemical abstracts Service Number 3380-34-5, 2012. http://www.ec.gc.ca/ese-ees/default.asp?lang=En&amp;n=6EF68BEC-1 ), and its physicochemical and toxicological characteristics indicate that there may be a risk to aquatic environments due to releases of the chemical in Canada.	Aspartic Acid	87-90	claudin 5	Homo sapiens	110-115
30470491-6	2019	Molecular docking suggested that the most potent compound 4 docked well in the ATP binding pocket of the four PDK isoforms, forming direct hydrogen bond interactions with the conserved amino acids Thr and Asp in ATP binding pocket of PDKs.	Aspartic Acid	205-208	pyruvate dehydrogenase kinase 1	Homo sapiens	234-238
31016108-3	2019	Herein, mesoionic dye A1094 encapsulated in Arg-Gly-Asp-modified hepatitis B virus core protein (RGD-HBc) is designed and synthesized for effective NIR II PAI of brain gliomas.	Aspartic Acid	52-55	keratin 88, pseudogene	Homo sapiens	101-104
30696704-4	2019	Molecular modeling indicated that all the residues of the ATP-binding site of the prototypical kinase PKA, except the catalytic aspartate, are conserved in the PKDs of GC-A and GC-B.	Aspartic Acid	128-137	grancalcin	Homo sapiens	168-172
30696704-4	2019	Molecular modeling indicated that all the residues of the ATP-binding site of the prototypical kinase PKA, except the catalytic aspartate, are conserved in the PKDs of GC-A and GC-B.	Aspartic Acid	128-137	natriuretic peptide receptor 2	Homo sapiens	177-181
30696704-5	2019	Kinase-inactivating alanine substitutions for the invariant lysine in subdomain II or the aspartate in the DYG-loop of GC-A and GC-B failed to decrease enzyme phosphate content, consistent with the PKDs lacking kinase activity.	Aspartic Acid	90-99	grancalcin	Homo sapiens	119-123
30800000-6	2019	Based on a 1H NMR-based metabolomics analysis, CLP-induced septic mice had increased levels of acetate, pyruvate, and lactate in serum and decreased levels of alanine, aspartate, glutamate, and fumarate in lungs.	Aspartic Acid	168-177	hyaluronan and proteoglycan link protein 1	Mus musculus	47-50
30692827-7	2019	The nucleotide substitution in exon 1 introduces a one amino acid substitution at residue 2 where an aspartic acid (D) in DRB1*15:02:01:01 is replaced by an asparagine (N) in DRB1*15:140.	Aspartic Acid	101-114	major histocompatibility complex, class II, DR beta 1	Homo sapiens	122-126
30638448-0	2019	The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex.	Aspartic Acid	14-23	mitochondrial calcium uniporter	Homo sapiens	32-35
30638448-0	2019	The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex.	Aspartic Acid	14-23	mitochondrial calcium uptake 1	Homo sapiens	45-50
30638448-5	2019	Here, we demonstrate that the DIME-aspartate mediates a Ca2+-modulated electrostatic interaction with MICU1, forming an MICU1 contact interface with a nearby Ser residue at the cytoplasmic entrance of the MCU pore.	Aspartic Acid	35-44	mitochondrial calcium uptake 1	Homo sapiens	102-107
30638448-5	2019	Here, we demonstrate that the DIME-aspartate mediates a Ca2+-modulated electrostatic interaction with MICU1, forming an MICU1 contact interface with a nearby Ser residue at the cytoplasmic entrance of the MCU pore.	Aspartic Acid	35-44	mitochondrial calcium uptake 1	Homo sapiens	120-125
30638448-5	2019	Here, we demonstrate that the DIME-aspartate mediates a Ca2+-modulated electrostatic interaction with MICU1, forming an MICU1 contact interface with a nearby Ser residue at the cytoplasmic entrance of the MCU pore.	Aspartic Acid	35-44	mitochondrial calcium uniporter	Homo sapiens	205-208
30321589-3	2019	Aspartate-glutamate carrier isoform 1 (AGC1), encoded by SLC25A12 gene, catalyzes an exchange between intramitochondrial aspartate and cytosolic glutamate plus a proton across the mitochondrial membrane, so supplying aspartate to the cytosol.	Aspartic Acid	121-130	solute carrier family 25 member 12	Homo sapiens	0-37
30321589-3	2019	Aspartate-glutamate carrier isoform 1 (AGC1), encoded by SLC25A12 gene, catalyzes an exchange between intramitochondrial aspartate and cytosolic glutamate plus a proton across the mitochondrial membrane, so supplying aspartate to the cytosol.	Aspartic Acid	121-130	solute carrier family 25 member 12	Homo sapiens	39-43
30321589-3	2019	Aspartate-glutamate carrier isoform 1 (AGC1), encoded by SLC25A12 gene, catalyzes an exchange between intramitochondrial aspartate and cytosolic glutamate plus a proton across the mitochondrial membrane, so supplying aspartate to the cytosol.	Aspartic Acid	121-130	solute carrier family 25 member 12	Homo sapiens	57-65
30321589-3	2019	Aspartate-glutamate carrier isoform 1 (AGC1), encoded by SLC25A12 gene, catalyzes an exchange between intramitochondrial aspartate and cytosolic glutamate plus a proton across the mitochondrial membrane, so supplying aspartate to the cytosol.	Aspartic Acid	217-226	solute carrier family 25 member 12	Homo sapiens	0-37
30321589-3	2019	Aspartate-glutamate carrier isoform 1 (AGC1), encoded by SLC25A12 gene, catalyzes an exchange between intramitochondrial aspartate and cytosolic glutamate plus a proton across the mitochondrial membrane, so supplying aspartate to the cytosol.	Aspartic Acid	217-226	solute carrier family 25 member 12	Homo sapiens	39-43
30321589-3	2019	Aspartate-glutamate carrier isoform 1 (AGC1), encoded by SLC25A12 gene, catalyzes an exchange between intramitochondrial aspartate and cytosolic glutamate plus a proton across the mitochondrial membrane, so supplying aspartate to the cytosol.	Aspartic Acid	217-226	solute carrier family 25 member 12	Homo sapiens	57-65
30321589-7	2019	AGC1 sustains HCC cell growth by supplying cytosolic aspartate for nucleotide biosynthesis.	Aspartic Acid	53-62	solute carrier family 25 member 12	Homo sapiens	0-4
30687076-7	2018	Samples with APOE epsilon4 also exhibited higher PCho/Cr (p = 0.0002), GPCho/Cr (p = 0.0001), alpha&amp;beta-Glc/Cr (p &lt; 0.0001), and lower Asp/Cr (p = 0.004) and GABA/Cr (p = 0.04) than the samples with APOE epsilon3 did.	Aspartic Acid	143-146	apolipoprotein E	Homo sapiens	13-17
30634463-2	2019	ASNase"s anticancer activity results from the enzymatic depletion of asparagine (Asn) and glutamine (Gln), which are converted to aspartic acid (Asp) and glutamic acid (Glu), respectively, in the blood.	Aspartic Acid	130-143	asparaginase like 1	Mus musculus	0-6
30634463-2	2019	ASNase"s anticancer activity results from the enzymatic depletion of asparagine (Asn) and glutamine (Gln), which are converted to aspartic acid (Asp) and glutamic acid (Glu), respectively, in the blood.	Aspartic Acid	145-148	asparaginase like 1	Mus musculus	0-6
30352320-5	2019	We found that ITGA5 is highly expressed in strongly migratory and invasive TNBC cells as well as their lung metastatic foci, which rationalizes active-targeted drug delivery to TNBC cells via ITGA5 ligands such as a commercialized ligand-RGD motif (Arg-Gly-Asp).	Aspartic Acid	257-260	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	14-19
30352320-5	2019	We found that ITGA5 is highly expressed in strongly migratory and invasive TNBC cells as well as their lung metastatic foci, which rationalizes active-targeted drug delivery to TNBC cells via ITGA5 ligands such as a commercialized ligand-RGD motif (Arg-Gly-Asp).	Aspartic Acid	257-260	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	192-197
30692827-7	2019	The nucleotide substitution in exon 1 introduces a one amino acid substitution at residue 2 where an aspartic acid (D) in DRB1*15:02:01:01 is replaced by an asparagine (N) in DRB1*15:140.	Aspartic Acid	101-114	major histocompatibility complex, class II, DR beta 1	Homo sapiens	175-179
31353333-3	2019	On page 126, on the bottom line of the left column, the sentence opening "Conversion of these two conserved basic amino acids in either Mcm4, 6 or 7 in S. cerevisiae to aspartic acid did not affect cell growth," should be changed to "Conversion of these two conserved basic amino acids in either Mcm4, 6 or 7 in S. cerevisiae to alanine did not affect cell growth,".	Aspartic Acid	169-182	MCM DNA helicase complex subunit MCM4	Saccharomyces cerevisiae S288C	136-140
31353333-3	2019	On page 126, on the bottom line of the left column, the sentence opening "Conversion of these two conserved basic amino acids in either Mcm4, 6 or 7 in S. cerevisiae to aspartic acid did not affect cell growth," should be changed to "Conversion of these two conserved basic amino acids in either Mcm4, 6 or 7 in S. cerevisiae to alanine did not affect cell growth,".	Aspartic Acid	169-182	MCM DNA helicase complex subunit MCM4	Saccharomyces cerevisiae S288C	296-300
31353333-5	2019	3 legend, the second sentence "Two conserved basic amino acids in the amino-terminal region of Mcm4, 6 and 7 proteins were mutated to aspartic acid in S. cerevisiae (Froelich et al., 2014)."	Aspartic Acid	134-147	MCM DNA helicase complex subunit MCM4	Saccharomyces cerevisiae S288C	95-99
31041876-9	2019	Genetic analysis revealed an aspartic acid to asparagine mutation, D109N, in the beta2-subunit.	Aspartic Acid	29-42	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	81-86
30171712-5	2019	Site Finder and molecular docking defined the thiazolidinones interactions with the most important catalytic residues of DNase I, including the H-acceptor interaction with residues His 134 and His 252 and/or H-donor interaction with residues Glu 39 and Asp 168.	Aspartic Acid	253-256	deoxyribonuclease 1	Rattus norvegicus	121-128
30526254-8	2019	Among this large set of mAbs, relatively high frequencies of asparagine deamidation events were observed in CDRs H2 and L1, while CDRs H3, H2 and L1 contained relatively high frequencies of instances of aspartate isomerization.	Aspartic Acid	203-212	relaxin 2	Homo sapiens	130-148
31939163-1	2019	CAD is a 1.5 MDa particle formed by hexameric association of a 250 kDa protein that carries the enzymatic activities for the first three steps in the de novo biosynthesis of pyrimidine nucleotides: glutamine-dependent Carbamoyl phosphate synthetase, Aspartate transcarbamoylase and Dihydroorotase.	Aspartic Acid	250-259	aconitate decarboxylase 1	Homo sapiens	0-3
32124747-6	2019	The increased risk of influenza development is associated with the Asp/Gly genotype of TLR-4 (OR=4.22) and combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2 (OR=15.0); influenza-associated pneumonia - with genotype Phe/Phe of TLR-3 (OR=4.5).	Aspartic Acid	67-70	toll like receptor 4	Homo sapiens	87-92
30488955-7	2019	In the propositus and father, a novel mutation c.1373 A &gt; G was found in exon 10 of ITGB3 resulting in the substitution of an aspartic acid for a glycine (p.Asp458Gly).	Aspartic Acid	129-142	integrin subunit beta 3	Homo sapiens	87-92
30669784-19	2018	The levels of aspartate and alanine aminotransferases in peripheral blood of mice in IL-17 group were significantly higher than other three groups (P &lt; 0.05).	Aspartic Acid	14-23	interleukin 17A	Mus musculus	85-90
32124747-9	2019	Markers of increased risk of influenza are 299Gly allele and genotype Asp/Gly of TLR-4 and the combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2; for influenza-associated pneumonia - allele 412Phe and genotype Phe/Phe of TLR-3.	Aspartic Acid	161-164	toll like receptor 3	Homo sapiens	150-155
30384606-8	2018	Finally, the cocrystal structures also identified that aspartic acid residues 176 and 218 in ROCK2, which are glutamic acids in PKA, could be targeted as residues to drive both potency and kinome selectivity.	Aspartic Acid	55-68	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	93-98
30373772-6	2018	We found that two D(E)N motifs form a head group-binding site, in which the carboxylate group of Asp-30 is important for LPL head group recognition.	Aspartic Acid	97-100	lipoprotein lipase	Homo sapiens	121-124
32124747-6	2019	The increased risk of influenza development is associated with the Asp/Gly genotype of TLR-4 (OR=4.22) and combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2 (OR=15.0); influenza-associated pneumonia - with genotype Phe/Phe of TLR-3 (OR=4.5).	Aspartic Acid	173-176	toll like receptor 3	Homo sapiens	162-167
32124747-6	2019	The increased risk of influenza development is associated with the Asp/Gly genotype of TLR-4 (OR=4.22) and combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2 (OR=15.0); influenza-associated pneumonia - with genotype Phe/Phe of TLR-3 (OR=4.5).	Aspartic Acid	173-176	toll like receptor 4	Homo sapiens	184-189
32124747-6	2019	The increased risk of influenza development is associated with the Asp/Gly genotype of TLR-4 (OR=4.22) and combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2 (OR=15.0); influenza-associated pneumonia - with genotype Phe/Phe of TLR-3 (OR=4.5).	Aspartic Acid	173-176	toll like receptor 2	Homo sapiens	205-210
32124747-6	2019	The increased risk of influenza development is associated with the Asp/Gly genotype of TLR-4 (OR=4.22) and combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2 (OR=15.0); influenza-associated pneumonia - with genotype Phe/Phe of TLR-3 (OR=4.5).	Aspartic Acid	173-176	toll like receptor 3	Homo sapiens	280-285
30373773-8	2018	Substitutions of individual amino acids within this region demonstrated that residues Asn-37, Thr-40, and Asp-42 of the murine cytokine were responsible for limited LIFR activation and absence of human OSMR/LIFR signaling.	Aspartic Acid	106-109	LIF receptor alpha	Mus musculus	165-169
30361439-10	2018	A model of glycosylated CD16b bound to IgG1 Fc determined to 2.2 A resolution combined with a 250-ns all-atom molecular dynamics simulation showed that the larger Asp-129 residue deformed the Fc-binding surface.	Aspartic Acid	163-166	Fc gamma receptor IIIb	Homo sapiens	24-29
30361439-11	2018	These results reveal how Asp-129 in CD16b affects its binding affinity for IgG1 Fc and suggest that antibodies engineered to engage CD16b with high affinity must accommodate the Asp-129 side chain.	Aspartic Acid	25-28	Fc gamma receptor IIIb	Homo sapiens	36-41
30361439-11	2018	These results reveal how Asp-129 in CD16b affects its binding affinity for IgG1 Fc and suggest that antibodies engineered to engage CD16b with high affinity must accommodate the Asp-129 side chain.	Aspartic Acid	25-28	Fc gamma receptor IIIb	Homo sapiens	132-137
30361439-11	2018	These results reveal how Asp-129 in CD16b affects its binding affinity for IgG1 Fc and suggest that antibodies engineered to engage CD16b with high affinity must accommodate the Asp-129 side chain.	Aspartic Acid	178-181	Fc gamma receptor IIIb	Homo sapiens	36-41
30361439-11	2018	These results reveal how Asp-129 in CD16b affects its binding affinity for IgG1 Fc and suggest that antibodies engineered to engage CD16b with high affinity must accommodate the Asp-129 side chain.	Aspartic Acid	178-181	Fc gamma receptor IIIb	Homo sapiens	132-137
30566880-4	2018	Effects on Deltapsim were a consequence of PGE2-initiated transcriptional regulation of genes, particularly Got1, in the malate-aspartate shuttle (MAS).	Aspartic Acid	128-137	glutamic-oxaloacetic transaminase 1	Homo sapiens	108-112
30358774-2	2018	Herein, we report on cyclic arginine-glycine-aspartic acid (cRGD) peptide conjugated ultrasmall CuS nanoparticles (CuS@BSA-RGD NPs) which encapsulate bovine serum albumin (BSA) and possess high optical absorption at 1064 nm.	Aspartic Acid	45-58	albumin	Mus musculus	157-170
30474653-6	2018	The evolutionarily conserved amino acid residues Asp-31, Trp-32, and Asp-33 are indispensable for the heparin-binding activity.	Aspartic Acid	49-52	thioredoxin like 1	Homo sapiens	57-63
30304469-4	2018	By pull-down, biophysical and biochemical analyses, we identified a novel Zalpha-interacting protein, MBD3, and revealed that Zalpha interacted with its C-terminal acidic region, an aspartate (D)/glutamate (E)-rich domain, with high affinity.	Aspartic Acid	182-191	methyl-CpG binding domain protein 3	Homo sapiens	102-106
30103136-3	2018	We demonstrate the precision and sensitivity of ACS measurements to small changes in MNP coating using arginine-glycine-aspartic acid (RGD) tripeptide binding, and subsequently discuss how ACS can be used to optimise the preparation of polyethyleneimine (PEI) functionalised MNPs aimed at nanomagnetic transfection applications.	Aspartic Acid	120-133	acyl-CoA synthetase short chain family member 2	Homo sapiens	48-51
30396010-6	2018	Stable Mate7 transfectants were then used for development and optimization of a new HTS cellular uptake protocol, with DAPI and ASP + as model fluorescent substrates.	Aspartic Acid	128-133	solute carrier family 47 member 4	Danio rerio	7-12
30404823-7	2018	The punctate distribution of AGS3-T602A was lost in an AGS3-A602T conversion mutant, but was still present upon T602 mutation to glutamate or aspartate.	Aspartic Acid	142-151	G protein signaling modulator 1	Homo sapiens	29-33
30478060-5	2018	Mutating all three of these sites to either alanines or aspartic acids impaired phyA function, changed the interactions of mutant phyA with FHY1 and FHL, and delayed the degradation of mutant phyA upon light exposure.	Aspartic Acid	56-70	phytochrome A	Arabidopsis thaliana	80-84
30478060-5	2018	Mutating all three of these sites to either alanines or aspartic acids impaired phyA function, changed the interactions of mutant phyA with FHY1 and FHL, and delayed the degradation of mutant phyA upon light exposure.	Aspartic Acid	56-70	phytochrome A	Arabidopsis thaliana	130-134
30478060-5	2018	Mutating all three of these sites to either alanines or aspartic acids impaired phyA function, changed the interactions of mutant phyA with FHY1 and FHL, and delayed the degradation of mutant phyA upon light exposure.	Aspartic Acid	56-70	phytochrome A	Arabidopsis thaliana	130-134
30244971-4	2018	The mTORC1/4E-BP axis regulates aspartate, asparagine, and serine synthesis by modulating mRNA translation, while ablation of 4E-BP1/2 substantially decreases sensitivity of breast cancer and melanoma cells to KI/biguanide combinations.	Aspartic Acid	32-41	CREB regulated transcription coactivator 1	Mus musculus	4-10
30514892-2	2018	Here, the impact of conjugation of biomimetic aspartic acid (ASP) and glutamic acid (GLU) templated peptides with poly(lactic-co-glycolic acid) (PLGA) electrospun NF on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) was evaluated.	Aspartic Acid	46-59	assembly factor for spindle microtubules	Homo sapiens	61-64
30510197-3	2018	T378/382 occur within optimal consensus Chk1 phosphorylation motifs and substitution with phospho-mimetic aspartic acid residues results in a constitutively active mutant Chk1 kinase (Chk1-DD) that arrests cell cycle progression in G2 phase of the cell cycle in the absence of DNA damage.	Aspartic Acid	106-119	checkpoint kinase 1	Homo sapiens	171-175
30510197-3	2018	T378/382 occur within optimal consensus Chk1 phosphorylation motifs and substitution with phospho-mimetic aspartic acid residues results in a constitutively active mutant Chk1 kinase (Chk1-DD) that arrests cell cycle progression in G2 phase of the cell cycle in the absence of DNA damage.	Aspartic Acid	106-119	checkpoint kinase 1	Homo sapiens	171-175
30560135-5	2018	This effect was associated with a significantly higher uptake of glutamate/aspartate in pept-1 than in wildtype C. elegans.	Aspartic Acid	75-84	Peptide transporter family 1	Caenorhabditis elegans	88-94
30419358-2	2018	The structure of AtPPC3, a C3 PEPC isozyme of the model plant Arabidopsis thaliana, in complex with the inhibitors aspartate and citrate was solved at 2.2-A resolution.	Aspartic Acid	115-124	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	17-23
30419358-2	2018	The structure of AtPPC3, a C3 PEPC isozyme of the model plant Arabidopsis thaliana, in complex with the inhibitors aspartate and citrate was solved at 2.2-A resolution.	Aspartic Acid	115-124	phosphoenolpyruvate carboxylase	Solanum tuberosum	30-34
30419358-7	2018	Citrate and aspartate inhibition of AtPPC3 was non-additive, likely due to their closely positioned binding sites, their similar negative charge, and type of binding residues.	Aspartic Acid	12-21	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	36-42
30385272-0	2018	Coronin 1 derived tryptophan-aspartic acid containing peptides inhibit membrane fusion.	Aspartic Acid	29-42	coronin 1A	Homo sapiens	0-9
30385272-8	2018	Interestingly, coronin 1 contains tryptophan-aspartic acid repeats, which are conserved across species.	Aspartic Acid	45-58	coronin 1A	Homo sapiens	15-24
30187212-3	2018	The primary sequence of prothymosin-alpha is highly acidic, with almost 50% comprised of Asp and Glu, and is unusual for a Zn2+-binding protein as it lacks Cys and His residues.	Aspartic Acid	89-92	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30384612-1	2018	In this article, we have designed l-aspartic acid-linked naphthalene diimide (NDI)-based amphiphilic molecules having a benzyl ester group at both the terminals with varying substituents (NAB-1-5).	Aspartic Acid	34-49	NGFI-A binding protein 1	Homo sapiens	188-195
30282806-7	2018	Site-directed mutagenesis further revealed that Asp-148, Arg-150, and Ser-151 cluster in a peptide loop essential for binding to Nav1.5.	Aspartic Acid	48-51	sodium voltage-gated channel alpha subunit 5	Homo sapiens	129-135
30335983-6	2018	As with many of the aminopyridine inhibitors, a critical active site Asp residue in nNOS versus Asn in eNOS is largely responsible for controlling selectivity.	Aspartic Acid	69-72	nitric oxide synthase 1	Homo sapiens	84-88
30459425-2	2018	TRPA1 assembles as a tetramer, with a central pore within which an aspartate residue (D918) determines Ca2+ permeability.	Aspartic Acid	67-76	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
30122555-2	2018	Here, we show that mitochondrial aspartate export via the aspartate-glutamate carrier 1 (AGC1) supports cell proliferation and cellular redox homeostasis.	Aspartic Acid	33-42	solute carrier family 25 member 12	Homo sapiens	58-87
30122555-2	2018	Here, we show that mitochondrial aspartate export via the aspartate-glutamate carrier 1 (AGC1) supports cell proliferation and cellular redox homeostasis.	Aspartic Acid	33-42	solute carrier family 25 member 12	Homo sapiens	89-93
30282806-9	2018	Examination of MOG1"s 3D structure revealed that Glu-83 and the loop containing Asp-148, Arg-150, and Ser-151 are spatially proximal, suggesting that these residues form a critical binding site for Nav1.5.	Aspartic Acid	80-83	RAN guanine nucleotide release factor	Homo sapiens	15-19
30282806-9	2018	Examination of MOG1"s 3D structure revealed that Glu-83 and the loop containing Asp-148, Arg-150, and Ser-151 are spatially proximal, suggesting that these residues form a critical binding site for Nav1.5.	Aspartic Acid	80-83	sodium voltage-gated channel alpha subunit 5	Homo sapiens	198-204
30122553-3	2018	We show here that p53 promotes the expression of SLC1A3, an aspartate/glutamate transporter that allows the utilization of aspartate to support cells in the absence of extracellular glutamine.	Aspartic Acid	60-69	tumor protein p53	Homo sapiens	18-21
30122553-3	2018	We show here that p53 promotes the expression of SLC1A3, an aspartate/glutamate transporter that allows the utilization of aspartate to support cells in the absence of extracellular glutamine.	Aspartic Acid	60-69	solute carrier family 1 member 3	Homo sapiens	49-55
30122555-3	2018	Insufficient cytosolic aspartate delivery leads to cell death when TCA cycle carbon is reduced following glutamine withdrawal and/or glutaminase inhibition.	Aspartic Acid	23-32	glutaminase	Homo sapiens	133-144
30335983-6	2018	As with many of the aminopyridine inhibitors, a critical active site Asp residue in nNOS versus Asn in eNOS is largely responsible for controlling selectivity.	Aspartic Acid	69-72	nitric oxide synthase 3	Homo sapiens	103-107
30393775-5	2018	Supplementation of aspartate, depletion of mitochondria, and knockdown of ASNS all protect the arginine-starved cells, establishing the causal effects of aspartate depletion and mitochondrial dysfunction on the arginine starvation-induced cell death.	Aspartic Acid	154-163	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	74-78
30450190-1	2018	Background: It has been reported that CBP/p300-Interacting Transactivator with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain 1 (CITED1) is overexpressed in papillary thyroid cancer (PTC).	Aspartic Acid	97-110	CREB binding protein	Mus musculus	38-46
30450190-1	2018	Background: It has been reported that CBP/p300-Interacting Transactivator with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain 1 (CITED1) is overexpressed in papillary thyroid cancer (PTC).	Aspartic Acid	97-110	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Mus musculus	141-147
30389987-7	2018	Further, the carboxylate group of a conserved aspartate of PglB mediates an interaction network between the reducing-end sugar of the LLO, the asparagine side chain of the acceptor peptide, and a bound divalent metal ion.	Aspartic Acid	46-55	epiphycan	Homo sapiens	59-63
30297026-6	2018	The growth phenotype of S. cerevisiae cells lacking the genes ymc2 and agc1, which encodes the only other S. cerevisiae carrier capable to transport glutamate besides aspartate, was fully complemented by expressing Ymc2p, Agc1p or BOU.	Aspartic Acid	167-176	organic acid transporter	Saccharomyces cerevisiae S288C	62-66
30297026-6	2018	The growth phenotype of S. cerevisiae cells lacking the genes ymc2 and agc1, which encodes the only other S. cerevisiae carrier capable to transport glutamate besides aspartate, was fully complemented by expressing Ymc2p, Agc1p or BOU.	Aspartic Acid	167-176	citrin	Saccharomyces cerevisiae S288C	71-75
30201683-5	2018	In this study, we found a novel Foxo1 regulatory mechanism by glucagon, which promotes Foxo1 nuclear translocation and stability via cAMP- and protein kinase A-dependent phosphorylation of Foxo1 at Ser276 Replacing Foxo1-S276 with alanine (A) or aspartate (D) to block or mimic phosphorylation, respectively, markedly regulates Foxo1 stability and nuclear localization in human hepatocytes.	Aspartic Acid	246-255	forkhead box O1	Homo sapiens	32-37
30201683-5	2018	In this study, we found a novel Foxo1 regulatory mechanism by glucagon, which promotes Foxo1 nuclear translocation and stability via cAMP- and protein kinase A-dependent phosphorylation of Foxo1 at Ser276 Replacing Foxo1-S276 with alanine (A) or aspartate (D) to block or mimic phosphorylation, respectively, markedly regulates Foxo1 stability and nuclear localization in human hepatocytes.	Aspartic Acid	246-255	forkhead box O1	Homo sapiens	87-92
30201683-5	2018	In this study, we found a novel Foxo1 regulatory mechanism by glucagon, which promotes Foxo1 nuclear translocation and stability via cAMP- and protein kinase A-dependent phosphorylation of Foxo1 at Ser276 Replacing Foxo1-S276 with alanine (A) or aspartate (D) to block or mimic phosphorylation, respectively, markedly regulates Foxo1 stability and nuclear localization in human hepatocytes.	Aspartic Acid	246-255	forkhead box O1	Homo sapiens	87-92
30201683-5	2018	In this study, we found a novel Foxo1 regulatory mechanism by glucagon, which promotes Foxo1 nuclear translocation and stability via cAMP- and protein kinase A-dependent phosphorylation of Foxo1 at Ser276 Replacing Foxo1-S276 with alanine (A) or aspartate (D) to block or mimic phosphorylation, respectively, markedly regulates Foxo1 stability and nuclear localization in human hepatocytes.	Aspartic Acid	246-255	forkhead box O1	Homo sapiens	87-92
30201683-5	2018	In this study, we found a novel Foxo1 regulatory mechanism by glucagon, which promotes Foxo1 nuclear translocation and stability via cAMP- and protein kinase A-dependent phosphorylation of Foxo1 at Ser276 Replacing Foxo1-S276 with alanine (A) or aspartate (D) to block or mimic phosphorylation, respectively, markedly regulates Foxo1 stability and nuclear localization in human hepatocytes.	Aspartic Acid	246-255	forkhead box O1	Homo sapiens	87-92
30483387-6	2018	The significant metabolites in the PTC group compared to healthy subjects also included scyllo- and myo-inositol, tryptophan, propionate, lactate, homocysteine, 3-methyl glutaric acid, asparagine, aspartate, choline, and acetamide.	Aspartic Acid	197-206	coiled-coil domain containing 6	Homo sapiens	35-38
30015387-3	2018	We hypothesize that ITCs, as electrophiles, can interact with the catalytic triads (CYS, HIS, and ASP) of the proteasomal cysteine deubiquitinases USP14 and UCHL5, ultimately inhibiting their activities.	Aspartic Acid	98-101	ubiquitin specific peptidase 14	Homo sapiens	147-152
30015387-3	2018	We hypothesize that ITCs, as electrophiles, can interact with the catalytic triads (CYS, HIS, and ASP) of the proteasomal cysteine deubiquitinases USP14 and UCHL5, ultimately inhibiting their activities.	Aspartic Acid	98-101	ubiquitin C-terminal hydrolase L5	Homo sapiens	157-162
30352365-2	2018	The precise role of ADAMDEC1 is uncertain and uniquely among metalloproteinases it utilizes a zinc-coordinating aspartic acid residue which allows it to escape inhibition by tissue inhibitor of metalloprotease-3 (TIMP-3).	Aspartic Acid	112-125	ADAM like decysin 1	Homo sapiens	20-28
30352365-2	2018	The precise role of ADAMDEC1 is uncertain and uniquely among metalloproteinases it utilizes a zinc-coordinating aspartic acid residue which allows it to escape inhibition by tissue inhibitor of metalloprotease-3 (TIMP-3).	Aspartic Acid	112-125	TIMP metallopeptidase inhibitor 3	Homo sapiens	174-211
30352365-2	2018	The precise role of ADAMDEC1 is uncertain and uniquely among metalloproteinases it utilizes a zinc-coordinating aspartic acid residue which allows it to escape inhibition by tissue inhibitor of metalloprotease-3 (TIMP-3).	Aspartic Acid	112-125	TIMP metallopeptidase inhibitor 3	Homo sapiens	213-219
30333187-7	2018	Purified MARF1 cleaved ssRNAs in vitro, but this cleavage activity was abolished by mutations of conserved aspartates in its NYN domain and truncation of the LOTUS domain.	Aspartic Acid	107-117	meiosis regulator and mRNA stability 1	Mus musculus	9-14
30393775-7	2018	Our data challenge the view that ASNS promotes homeostasis, arguing instead that ASNS-induced aspartate depletion promotes cytotoxicity, which can be exploited for anti-cancer therapies.	Aspartic Acid	94-103	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	81-85
30388170-10	2018	While no effect of cholesterol was observed, these data show that CPO does function as an active enzyme within the ER where it removes C-terminal glutamates and aspartates, as well as a number of polar amino acids.	Aspartic Acid	161-171	carboxypeptidase O	Canis lupus familiaris	66-69
30422000-2	2018	Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the genetically precise TREX1 D18N mice recapitulate a lupus-like disease.	Aspartic Acid	16-25	three prime repair exonuclease 1	Homo sapiens	44-76
30422000-2	2018	Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the genetically precise TREX1 D18N mice recapitulate a lupus-like disease.	Aspartic Acid	16-25	three prime repair exonuclease 1	Homo sapiens	78-83
30422000-2	2018	Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the genetically precise TREX1 D18N mice recapitulate a lupus-like disease.	Aspartic Acid	16-25	three prime repair exonuclease 1	Homo sapiens	171-176
30028003-0	2018	Distal renal tubular acidosis caused by tryptophan-aspartate repeat domain 72 (WDR72) mutations.	Aspartic Acid	51-60	WD repeat domain 72	Homo sapiens	79-84
30028003-4	2018	Here, we report compound heterozygous pathogenic variations in tryptophan-aspartate repeat domain 72 (WDR72) (c.1777A>G [p.R593G] and c.2522T>A [p.L841Q]) in three affected siblings of a family with dRTA.	Aspartic Acid	74-83	WD repeat domain 72	Homo sapiens	102-107
30333187-5	2018	The N-terminal NYN domain of MARF1 resembles the nuclease domains of Vpa0982, T4 RNase H, and MCPIP1 and contains four conserved aspartate residues, D178, D215, D246, and D272.	Aspartic Acid	129-138	meiosis regulator and mRNA stability 1	Mus musculus	29-34
30270390-7	2018	All coordinating groups present in the Fe(iii) transferrin complex are also found for Cm(iii), i.e. Asp 63, Tyr 95, Tyr 188 and His 249.	Aspartic Acid	100-103	transferrin	Homo sapiens	47-58
30252477-4	2018	The ion selectivity for Mg2+ over Ca2+ resides at a central cavity in the transmembrane pore of MgtE, involving a conserved aspartate residue (Asp432) from each monomer.	Aspartic Acid	124-133	mucin 7, secreted	Homo sapiens	24-27
30252477-4	2018	The ion selectivity for Mg2+ over Ca2+ resides at a central cavity in the transmembrane pore of MgtE, involving a conserved aspartate residue (Asp432) from each monomer.	Aspartic Acid	124-133	solute carrier family 41 member 1	Homo sapiens	96-100
30270390-10	2018	The results underline an involvement of Asp 63, Tyr 95, Tyr 188 and His 249 as well as carbonate in Cm(iii) coordination at the transferrin Fe(iii) binding site.	Aspartic Acid	40-43	transferrin	Homo sapiens	128-139
29909197-3	2018	Caspase-3 as an apoptosis indicator could specifically cleave the N-terminus of biotinylated DEVD-peptide (biotin-Gly-Asp-Gly-Asp-Glu-Val-Asp-Gly-Cys) immobilized on the Au nanoparticle-decorated TiO2 nanotube arrays (TiO2/Au NTAs) substrate.	Aspartic Acid	118-121	caspase 3	Homo sapiens	0-9
30189200-5	2018	The PRK2 peptide resides in the canonical PDZ3 binding cleft in an elongated manner and the amino acid side chains in position P0 and P-2, cysteine and aspartate, of the ligand face the groove between EB-strand and DB-helix, whereas the PRK2 side chains of tryptophan and alanine located in position P-1 and P-3 point away from the binding cleft.	Aspartic Acid	152-161	protein kinase N2	Mus musculus	4-8
30328809-4	2018	FGF produced in the larval wing imaginal-disc moves to the air-sac-primordium (ASP) through FGFR-containing cytonemes that extend from the ASP to contact the wing-disc source.	Aspartic Acid	79-82	branchless	Drosophila melanogaster	0-3
30328809-4	2018	FGF produced in the larval wing imaginal-disc moves to the air-sac-primordium (ASP) through FGFR-containing cytonemes that extend from the ASP to contact the wing-disc source.	Aspartic Acid	79-82	breathless	Drosophila melanogaster	92-96
30328809-6	2018	Acting as a morphogen in the ASP, FGF activates concentration-dependent gene expression, inducing pointed-P1 at higher and cut at lower levels.	Aspartic Acid	29-32	branchless	Drosophila melanogaster	34-37
30333243-1	2018	Formation of hydroxyapatite (HAP) within collagen fibrils, as found in bone, dentine and cementum, is thought to be mediated by proteins rich in aspartate (Asp) and glutamate such as osteopontin and bone sialoprotein, respectively.	Aspartic Acid	145-154	secreted phosphoprotein 1	Mus musculus	183-194
30279180-2	2018	Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients to multisystem proteinopathy.	Aspartic Acid	14-27	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	43-50
30279180-3	2018	Mutation of aspartic acid 262 of hnRNPA1 to either valine or asparagine has been linked to either amyotrophic lateral sclerosis or multisystem proteinopathy.	Aspartic Acid	12-25	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	33-40
30279180-4	2018	Mutation of aspartic acid 378 of hnRNPDL to either asparagine or histidine has been associated with limb girdle muscular dystrophy.	Aspartic Acid	12-25	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	33-40
29909197-3	2018	Caspase-3 as an apoptosis indicator could specifically cleave the N-terminus of biotinylated DEVD-peptide (biotin-Gly-Asp-Gly-Asp-Glu-Val-Asp-Gly-Cys) immobilized on the Au nanoparticle-decorated TiO2 nanotube arrays (TiO2/Au NTAs) substrate.	Aspartic Acid	126-129	caspase 3	Homo sapiens	0-9
30009907-4	2018	Besides, ASP could significantly inhibit the growth of H22 heptoma cells in vivo via improving the levels of serum cytokines (TNF-alpha, IL-2 and IFN-gamma) and activities of immune cells (macrophages, lymphocytes and NK cells), thereby inducing tumor cell apoptosis and attenuating their accessional damages.	Aspartic Acid	9-12	tumor necrosis factor	Mus musculus	126-135
30009907-4	2018	Besides, ASP could significantly inhibit the growth of H22 heptoma cells in vivo via improving the levels of serum cytokines (TNF-alpha, IL-2 and IFN-gamma) and activities of immune cells (macrophages, lymphocytes and NK cells), thereby inducing tumor cell apoptosis and attenuating their accessional damages.	Aspartic Acid	9-12	interleukin 2	Mus musculus	137-141
30009907-4	2018	Besides, ASP could significantly inhibit the growth of H22 heptoma cells in vivo via improving the levels of serum cytokines (TNF-alpha, IL-2 and IFN-gamma) and activities of immune cells (macrophages, lymphocytes and NK cells), thereby inducing tumor cell apoptosis and attenuating their accessional damages.	Aspartic Acid	9-12	interferon gamma	Mus musculus	146-155
30077007-6	2018	Substitution of gluconate or aspartate for chloride in the bath solution blocked voltage-gated outward currents and shifted the reversal potential of Panx1 currents to the right, indicating the anion permeability of this channel.	Aspartic Acid	29-38	pannexin 1	Mus musculus	150-155
30209241-4	2018	Here, we show that LDHA activity supports serine and aspartate biosynthesis.	Aspartic Acid	53-62	lactate dehydrogenase A	Homo sapiens	19-23
30209241-6	2018	Reduced intracellular serine and aspartate following LDHA inhibition engage GCN2-ATF4 signaling to initiate an expansive pro-survival response.	Aspartic Acid	33-42	lactate dehydrogenase A	Homo sapiens	53-57
30209241-6	2018	Reduced intracellular serine and aspartate following LDHA inhibition engage GCN2-ATF4 signaling to initiate an expansive pro-survival response.	Aspartic Acid	33-42	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	76-80
30209241-6	2018	Reduced intracellular serine and aspartate following LDHA inhibition engage GCN2-ATF4 signaling to initiate an expansive pro-survival response.	Aspartic Acid	33-42	activating transcription factor 4	Homo sapiens	81-85
29763372-4	2018	Both mitochondrial glutamate oxaloacetate transaminase 2 (GOT2) and malate dehydrogenase 2 (MDH2) were acetylated, and the malate-aspartate shuttle (MAS) activity was stimulated to maintain glycolysis.	Aspartic Acid	130-139	malate dehydrogenase, mitochondrial	Sus scrofa	92-96
30073608-1	2018	Bacterial L-aspartate alpha-decarboxylase (PanD) specifically catalyzes the decarboxylation of L-aspartic acid to beta-alanine.	Aspartic Acid	95-110	PAND1	Homo sapiens	43-47
29960169-10	2018	Hypoxia treatment up-regulated miR-22 expression, and the up-regulation was mitigated by ASP pretreatment.	Aspartic Acid	89-92	microRNA 22	Rattus norvegicus	31-37
29960169-11	2018	Effects of ASP pretreatment on hypoxia-treated H9c2 cells were mitigated by miR-22 overexpression while were augmented by miR-22 inhibition.	Aspartic Acid	11-14	microRNA 22	Rattus norvegicus	76-82
29960169-11	2018	Effects of ASP pretreatment on hypoxia-treated H9c2 cells were mitigated by miR-22 overexpression while were augmented by miR-22 inhibition.	Aspartic Acid	11-14	microRNA 22	Rattus norvegicus	122-128
29960169-12	2018	Phosphorylation levels of PI3K, AKT, JAK1 and STAT3 were increased by ASP through down-regulating miR-22 in hypoxia-treated H9c2 cells.	Aspartic Acid	70-73	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
29960169-12	2018	Phosphorylation levels of PI3K, AKT, JAK1 and STAT3 were increased by ASP through down-regulating miR-22 in hypoxia-treated H9c2 cells.	Aspartic Acid	70-73	Janus kinase 1	Rattus norvegicus	37-41
29960169-12	2018	Phosphorylation levels of PI3K, AKT, JAK1 and STAT3 were increased by ASP through down-regulating miR-22 in hypoxia-treated H9c2 cells.	Aspartic Acid	70-73	signal transducer and activator of transcription 3	Rattus norvegicus	46-51
29960169-12	2018	Phosphorylation levels of PI3K, AKT, JAK1 and STAT3 were increased by ASP through down-regulating miR-22 in hypoxia-treated H9c2 cells.	Aspartic Acid	70-73	microRNA 22	Rattus norvegicus	98-104
29960169-13	2018	CONCLUSION: ASP pretreatment attenuated hypoxia-induced H9c2 cell injury, possibly through down-regulating miR-22 expression.	Aspartic Acid	12-15	microRNA 22	Rattus norvegicus	107-113
29960169-14	2018	The PI3K/AKT and JAK1/STAT3 pathways were activated by ASP pretreatment via miR-22 in hypoxia-treated cells.	Aspartic Acid	55-58	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
29960169-14	2018	The PI3K/AKT and JAK1/STAT3 pathways were activated by ASP pretreatment via miR-22 in hypoxia-treated cells.	Aspartic Acid	55-58	Janus kinase 1	Rattus norvegicus	17-21
29960169-14	2018	The PI3K/AKT and JAK1/STAT3 pathways were activated by ASP pretreatment via miR-22 in hypoxia-treated cells.	Aspartic Acid	55-58	signal transducer and activator of transcription 3	Rattus norvegicus	22-27
29960169-14	2018	The PI3K/AKT and JAK1/STAT3 pathways were activated by ASP pretreatment via miR-22 in hypoxia-treated cells.	Aspartic Acid	55-58	microRNA 22	Rattus norvegicus	76-82
30064080-7	2018	Molecular docking and Site Finder module defined the thieno[2,3-d]pyrimidines interactions with the most important catalytic residues of DNase I, including Glu 39, His 134, Asp 168 and His 252.	Aspartic Acid	173-176	deoxyribonuclease 1	Bos taurus	137-144
30056598-7	2018	Antibodies induced by Asp and iso-Asp p580 bound homologous regions of the EGFR family members HER2 and HER3.	Aspartic Acid	22-25	epidermal growth factor receptor	Homo sapiens	75-79
30056598-7	2018	Antibodies induced by Asp and iso-Asp p580 bound homologous regions of the EGFR family members HER2 and HER3.	Aspartic Acid	22-25	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-99
30056598-7	2018	Antibodies induced by Asp and iso-Asp p580 bound homologous regions of the EGFR family members HER2 and HER3.	Aspartic Acid	22-25	erb-b2 receptor tyrosine kinase 3	Homo sapiens	104-108
30056598-7	2018	Antibodies induced by Asp and iso-Asp p580 bound homologous regions of the EGFR family members HER2 and HER3.	Aspartic Acid	34-37	epidermal growth factor receptor	Homo sapiens	75-79
30056598-7	2018	Antibodies induced by Asp and iso-Asp p580 bound homologous regions of the EGFR family members HER2 and HER3.	Aspartic Acid	34-37	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-99
30056598-7	2018	Antibodies induced by Asp and iso-Asp p580 bound homologous regions of the EGFR family members HER2 and HER3.	Aspartic Acid	34-37	erb-b2 receptor tyrosine kinase 3	Homo sapiens	104-108
29972179-8	2018	Substitution of serine at positions 111 and 180 in AQP4 for aspartic acid showed only a marginal effect on pf, suggesting that negative entrance charges are of minor importance.	Aspartic Acid	60-73	aquaporin 4	Homo sapiens	51-55
30302399-4	2018	The identification of two C-terminal fragments of Kv7.1 led us to identify an aspartate critical for the generation of one of the fragments and caspases as responsible for mediating proteolysis.	Aspartic Acid	78-87	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	50-55
30181289-2	2018	We demonstrate that substituting H3G34 with arginine, valine, or aspartate (H3G34R/V/D), which converts the non-side chain glycine to a large side chain-containing residue, blocks H3 lysine 36 (H3K36) dimethylation and trimethylation by histone methyltransferases, including SETD2, an H3K36-specific trimethyltransferase.	Aspartic Acid	65-74	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	275-280
29883318-8	2018	The preference of trypsin-3 for aspartic acid in P2" is explained by salt bridge formation with the unique Arg193.	Aspartic Acid	32-45	serine protease 3	Homo sapiens	18-27
30100068-4	2018	We report that RILP is directly cleaved by caspase-1 and we have identified a novel caspase-1 recognition site at aspartic acid 75 within the RILP sequence.	Aspartic Acid	114-127	Rab interacting lysosomal protein	Homo sapiens	15-19
30100068-4	2018	We report that RILP is directly cleaved by caspase-1 and we have identified a novel caspase-1 recognition site at aspartic acid 75 within the RILP sequence.	Aspartic Acid	114-127	caspase 1	Homo sapiens	43-52
30100068-4	2018	We report that RILP is directly cleaved by caspase-1 and we have identified a novel caspase-1 recognition site at aspartic acid 75 within the RILP sequence.	Aspartic Acid	114-127	caspase 1	Homo sapiens	84-93
30100068-4	2018	We report that RILP is directly cleaved by caspase-1 and we have identified a novel caspase-1 recognition site at aspartic acid 75 within the RILP sequence.	Aspartic Acid	114-127	Rab interacting lysosomal protein	Homo sapiens	142-146
30093495-3	2018	We show here that nutritionally determined Q-tRNA levels promote Dnmt2-mediated methylation of tRNA Asp and control translational speed of Q-decoded codons as well as at near-cognate codons.	Aspartic Acid	100-103	tRNA aspartic acid methyltransferase 1	Homo sapiens	65-70
29351723-8	2018	Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells.	Aspartic Acid	24-33	uncoupling protein 2	Homo sapiens	10-14
30152697-3	2018	The peptide sequence Arg-Gly-Asp (RGD), which is present in a number of endogenous integrin ligands like fibronectin, vitronectin, and related proteins of the extracellular matrix (ECM), has been extensively used as a targeting vector for therapeutic as well as diagnostic purposes, and cilengitide, a cyclic RGD peptide, has entered clinical trials for the treatment of various cancers.	Aspartic Acid	29-32	fibronectin 1	Homo sapiens	105-116
30152697-3	2018	The peptide sequence Arg-Gly-Asp (RGD), which is present in a number of endogenous integrin ligands like fibronectin, vitronectin, and related proteins of the extracellular matrix (ECM), has been extensively used as a targeting vector for therapeutic as well as diagnostic purposes, and cilengitide, a cyclic RGD peptide, has entered clinical trials for the treatment of various cancers.	Aspartic Acid	29-32	vitronectin	Homo sapiens	118-129
33435063-1	2018	A novel PTH-derived peptide, PTHdP, including a repetitive aspartic acid sequence at the C-terminal and phosphorylated serine at the N-terminal has been previously designed.	Aspartic Acid	59-72	parathyroid hormone	Mus musculus	8-11
30175260-1	2018	D-aspartate, a natural and endogenous amino acid, widely exists in animal tissues and can be synthesized through aspartate racemase and transformed by D-aspartate oxidase (DDO).	Aspartic Acid	2-11	D-aspartate oxidase	Homo sapiens	151-170
30175260-1	2018	D-aspartate, a natural and endogenous amino acid, widely exists in animal tissues and can be synthesized through aspartate racemase and transformed by D-aspartate oxidase (DDO).	Aspartic Acid	2-11	D-aspartate oxidase	Homo sapiens	172-175
30011368-5	2018	Comparisons between (dl- threo)-19a-c and (dl- erythro)-19a-c Asp analogues confirmed that the threo configuration is crucial for the EAAT1-4 inhibitory activities.	Aspartic Acid	62-65	solute carrier family 1 member 3	Homo sapiens	134-141
30190457-4	2018	We identify that aspartic acids 5 and 13 at the N-terminus of apoA-IV are required for binding to alphaIIbbeta3 integrin, which is additionally modulated by apoA-IV C-terminus via intra-molecular interactions.	Aspartic Acid	17-31	apolipoprotein A4	Homo sapiens	62-69
30190457-4	2018	We identify that aspartic acids 5 and 13 at the N-terminus of apoA-IV are required for binding to alphaIIbbeta3 integrin, which is additionally modulated by apoA-IV C-terminus via intra-molecular interactions.	Aspartic Acid	17-31	apolipoprotein A4	Homo sapiens	157-164
30181442-7	2018	The studied compound was docked to the novel X-ray structure of the human dopamine D2 receptor in the inactive state (PDB ID: 6CM4) and established the main contact between its protonatable nitrogen atom and Asp (3.32) of the receptor.	Aspartic Acid	208-211	dopamine receptor D2	Homo sapiens	74-94
29486375-0	2018	Aspartic acid functionalized PEGylated MSN@GO hybrid as an effective and sustainable nano-system for in-vitro drug delivery.	Aspartic Acid	0-13	moesin	Homo sapiens	39-42
29486375-1	2018	PURPOSE: In this research, aspartic acid functionalized PEGylated mesoporous silica nanoparticlesgraphene oxide nanohybrid (As-PEGylated-MSN@GO) prepared as a pH-responsive drug carrier for the curcumin delivery.	Aspartic Acid	27-40	moesin	Homo sapiens	137-140
30003880-1	2018	Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid.	Aspartic Acid	107-120	secreted phosphoprotein 1	Homo sapiens	0-11
30003880-1	2018	Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid.	Aspartic Acid	107-120	secreted phosphoprotein 1	Homo sapiens	13-16
29995990-6	2018	These studies suggest that aspartate limitation depletes the peptidoglycan precursor meso-2,6-diaminopimelate (mDAP), inhibits peptidoglycan synthesis, upregulates the cell envelope stress response mediated by sigmaM and eventually leads to cell lysis.	Aspartic Acid	27-36	death-associated protein	Mus musculus	111-115
29908160-0	2018	Pseudo-phosphorylation at AT8 epitopes regulates the tau truncation at aspartate 421.	Aspartic Acid	71-80	microtubule associated protein tau	Homo sapiens	53-56
29651749-1	2018	Citrin, encoded by SLC25A13, constitutes the malate-aspartate shuttle, the main NADH-shuttle in the liver.	Aspartic Acid	52-61	solute carrier family 25 member 13	Homo sapiens	0-6
29651749-1	2018	Citrin, encoded by SLC25A13, constitutes the malate-aspartate shuttle, the main NADH-shuttle in the liver.	Aspartic Acid	52-61	solute carrier family 25 member 13	Homo sapiens	19-27
29959188-8	2018	This study demonstrated that UCH-L1 wild-type and cysteine to aspartic acid mutants, but not its cysteine to serine mutants, afforded neuroprotective effects against oxidative stress; there were no discernible differences between wild-type UCH-L1 and its mutants in the absence of oxidative stress.	Aspartic Acid	62-75	ubiquitin carboxy-terminal hydrolase L1	Mus musculus	29-35
29573323-1	2018	A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human alpha5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependence.	Aspartic Acid	77-90	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	42-48
30015051-3	2018	The Asp816 residue is located at the activation loop (A-loop) of c-Kit and the mutation can eliminate a negative formal charge from the loop region by substituting the acidic asparagic acid residue with neutral valine, histidine, tyrosine or phenylalanine.	Aspartic Acid	175-189	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	65-70
29884691-4	2018	To address this question, we screened the inhibitory effectiveness of 20 microM concentrations of several hundred compounds against OCT2-mediated uptake of six structurally distinct substrates: MPP, metformin, N,N,N-trimethyl-2-[methyl(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino]ethanaminium (NBD-MTMA), TEA, cimetidine, and 4-4-dimethylaminostyryl-N-methylpyridinium (ASP).	Aspartic Acid	369-372	POU class 2 homeobox 2	Homo sapiens	132-136
29884691-8	2018	Applying our ASP model to a previously published large-scale screening study for inhibition of OCT2-mediated ASP transport resulted in comparable statistics, with approximately 75% of "active" inhibitors predicted correctly.	Aspartic Acid	13-16	POU class 2 homeobox 2	Homo sapiens	95-99
29884691-8	2018	Applying our ASP model to a previously published large-scale screening study for inhibition of OCT2-mediated ASP transport resulted in comparable statistics, with approximately 75% of "active" inhibitors predicted correctly.	Aspartic Acid	109-112	POU class 2 homeobox 2	Homo sapiens	95-99
30224590-3	2018	Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers.	Aspartic Acid	125-134	glutathione S-transferase omega 1	Homo sapiens	85-90
30224590-3	2018	Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers.	Aspartic Acid	125-134	glutathione S-transferase omega 2	Homo sapiens	161-166
30224590-3	2018	Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers.	Aspartic Acid	206-215	glutathione S-transferase omega 1	Homo sapiens	85-90
30224590-3	2018	Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers.	Aspartic Acid	206-215	glutathione S-transferase omega 2	Homo sapiens	161-166
30120350-4	2018	A yeast two-hybrid assay revealed that the interaction between OsABIL2 and a putative rice ABA receptor, OsPYL1, was ABA-dependent, and the interaction was lost with amino acid substitution from glycine to aspartic acid at the 183rd amino acid of the OsABIL2 protein, corresponding to abi1-1 mutation.	Aspartic Acid	206-219	Protein phosphatase 2C family protein	Arabidopsis thaliana	285-289
30155513-3	2018	When expressed intracellularly as intrabodies, anti-alpha-syn nanobodies fused to a proteasome-targeting proline, aspartate or glutamate, serine, and threonine (PEST) motif can modulate monomeric concentrations of target proteins.	Aspartic Acid	114-123	synuclein alpha	Rattus norvegicus	52-61
30044634-2	2018	Fibronectin (Fn) holds two peptide sequences that favor cell adhesion: the Arg-Gly-Asp (RGD) loop on the tenth type-III domain (Fn-III10) and the Pro-His-Ser-Arg-Asn (PHSRN) synergy site on the ninth type-III domain (Fn-III9).	Aspartic Acid	83-86	fibronectin 1	Homo sapiens	0-11
30044634-2	2018	Fibronectin (Fn) holds two peptide sequences that favor cell adhesion: the Arg-Gly-Asp (RGD) loop on the tenth type-III domain (Fn-III10) and the Pro-His-Ser-Arg-Asn (PHSRN) synergy site on the ninth type-III domain (Fn-III9).	Aspartic Acid	83-86	fibronectin 1	Homo sapiens	13-15
30830367-10	2018	These metabolites, mainly involved in fatty acid metabolism, glycerophospholipid metabolism, alanine, aspartate and glutamate metabolism, are implicated in insulin resistance, vascular remodeling, macrophage activation and oxidised LDL formation.	Aspartic Acid	102-111	insulin	Homo sapiens	156-163
30030371-4	2018	Importantly, mutagenesis studies (Ser to Asp) showed that the effect of this phosphorylation of SNX27 phenocopies the effects seen upon loss of SNX27 function, affecting PM trafficking of cargo proteins that bind SNX27-retromer.	Aspartic Acid	41-44	sorting nexin 27	Homo sapiens	96-101
30135643-7	2018	Based on in silico analysis, Ser 252, His 470 and Asp 474 are predicted to be the catalytic triad responsible for CPT1C palmitoyl thioesterase (PTE) activity.	Aspartic Acid	50-53	carnitine palmitoyltransferase 1c	Mus musculus	114-119
29907572-9	2018	p17 interacts with cyclins by its cyclin-binding motif, 125RXL127 Sequence and mutagenic analyses of p17 indicated that a 140WXFD143 motif and residues Asp-113 and Lys-122 in p17 are critical for CDK2 and CDK6 binding, leading to their sequestration in the cytoplasm.	Aspartic Acid	152-155	family with sequence similarity 72 member B	Homo sapiens	0-3
29907572-9	2018	p17 interacts with cyclins by its cyclin-binding motif, 125RXL127 Sequence and mutagenic analyses of p17 indicated that a 140WXFD143 motif and residues Asp-113 and Lys-122 in p17 are critical for CDK2 and CDK6 binding, leading to their sequestration in the cytoplasm.	Aspartic Acid	152-155	cyclin B1	Homo sapiens	19-26
29907572-9	2018	p17 interacts with cyclins by its cyclin-binding motif, 125RXL127 Sequence and mutagenic analyses of p17 indicated that a 140WXFD143 motif and residues Asp-113 and Lys-122 in p17 are critical for CDK2 and CDK6 binding, leading to their sequestration in the cytoplasm.	Aspartic Acid	152-155	cyclin dependent kinase 2	Homo sapiens	196-200
29907572-9	2018	p17 interacts with cyclins by its cyclin-binding motif, 125RXL127 Sequence and mutagenic analyses of p17 indicated that a 140WXFD143 motif and residues Asp-113 and Lys-122 in p17 are critical for CDK2 and CDK6 binding, leading to their sequestration in the cytoplasm.	Aspartic Acid	152-155	cyclin dependent kinase 6	Homo sapiens	205-209
30068998-0	2018	The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency.	Aspartic Acid	96-105	OPA1, mitochondrial dynamin like GTPase	Mus musculus	42-46
30075744-11	2018	Alanine/aspartate/glutamate metabolism and choline-derived metabolites correlated with TNF-alpha synovial expression.	Aspartic Acid	8-17	tumor necrosis factor	Homo sapiens	87-96
29947431-0	2018	Conserved aspartate-to-glycine mutation in tyrosinase is associated with albino phenotype in domestic guinea pigs (Cavia porcellus).	Aspartic Acid	10-19	tyrosinase	Cavia porcellus	43-53
30260719-4	2018	CASE REPORT: We present a patient with persistent unconjugated hyperbilirubinemia, clinically diagnosed as CN-2, with a UGT1 A1 p. H39D (c.115C &gt; G) (His   Asp) mutation.	Aspartic Acid	159-162	carnosine dipeptidase 2	Homo sapiens	107-111
29673954-6	2018	The activity of PPARgamma was decreased in OA chondrocytes and increased when treated with ASP.	Aspartic Acid	91-94	peroxisome proliferator activated receptor gamma	Homo sapiens	16-25
30114340-9	2018	Mutation of the fifth residue, aspartate, to alanine or lysine has a dramatic impact on binding affinity for CCR6 and ligand potency.	Aspartic Acid	31-40	C-C motif chemokine receptor 6	Homo sapiens	109-113
29848639-11	2018	These results are in line with the recent finding that the single active-site aspartate was dispensable for activity in the guanosine-specific Trm10 from yeast, and suggest that also dual-specificity Trm10 orthologs use a noncanonical tRNA methyltransferase mechanism without residues acting as general base catalysts.	Aspartic Acid	78-87	tRNA (guanine(9)-N(1))-methyltransferase	Saccharomyces cerevisiae S288C	143-148
29848639-11	2018	These results are in line with the recent finding that the single active-site aspartate was dispensable for activity in the guanosine-specific Trm10 from yeast, and suggest that also dual-specificity Trm10 orthologs use a noncanonical tRNA methyltransferase mechanism without residues acting as general base catalysts.	Aspartic Acid	78-87	tRNA (guanine(9)-N(1))-methyltransferase	Saccharomyces cerevisiae S288C	200-205
30068998-6	2018	Interestingly, we recently reported significant variations of five of these molecules, including aspartate and glutamate, in the plasma of individuals carrying pathogenic OPA1 variants.	Aspartic Acid	97-106	OPA1, mitochondrial dynamin like GTPase	Mus musculus	171-175
30068998-7	2018	Our findings show that the disruption of OPA1 leads to a remodelling of bioenergetic pathways with the central role being played by aspartate and related metabolites.	Aspartic Acid	132-141	OPA1, mitochondrial dynamin like GTPase	Mus musculus	41-45
30108502-3	2018	In the present study, we found that ASP could enhance hypoxic induction of EPO in Hep3B cells, with a mechanism that involved the stabilization of HIF-2alpha protein.	Aspartic Acid	36-39	erythropoietin	Homo sapiens	75-78
30108502-3	2018	In the present study, we found that ASP could enhance hypoxic induction of EPO in Hep3B cells, with a mechanism that involved the stabilization of HIF-2alpha protein.	Aspartic Acid	36-39	endothelial PAS domain protein 1	Homo sapiens	147-157
30108502-4	2018	In parallel, ASP rescued the inhibition of EPO, induced by proinflammatory factor TNF-alpha through blocking GATA2 and NF-kappaB activation.	Aspartic Acid	13-16	erythropoietin	Rattus norvegicus	43-46
30108502-4	2018	In parallel, ASP rescued the inhibition of EPO, induced by proinflammatory factor TNF-alpha through blocking GATA2 and NF-kappaB activation.	Aspartic Acid	13-16	tumor necrosis factor	Rattus norvegicus	82-91
30108502-4	2018	In parallel, ASP rescued the inhibition of EPO, induced by proinflammatory factor TNF-alpha through blocking GATA2 and NF-kappaB activation.	Aspartic Acid	13-16	GATA binding protein 2	Rattus norvegicus	109-114
30108502-6	2018	By increasing the accumulation of HIF-2alpha protein and reducing the expression of NF-kappaB and GATA2 as well as pro-inflammatory cytokines, ASP stimulated both renal and hepatic EPO production, and resulted in an elevation of serum EPO.	Aspartic Acid	143-146	endothelial PAS domain protein 1	Rattus norvegicus	34-44
30105045-8	2018	In contrast, substitution of Asp-205 by Asn in EpHKT1;2 did not enhance salt tolerance and rather resulted in a similar function to that of AtHKT1 (Na+ influx but no K+ influx), indicating that the presence of Asn or Asp determines the mode of cation selectivity of the HKT1-type transporters.	Aspartic Acid	29-32	high-affinity K+ transporter 1	Arabidopsis thaliana	49-53
30108502-6	2018	By increasing the accumulation of HIF-2alpha protein and reducing the expression of NF-kappaB and GATA2 as well as pro-inflammatory cytokines, ASP stimulated both renal and hepatic EPO production, and resulted in an elevation of serum EPO.	Aspartic Acid	143-146	GATA binding protein 2	Rattus norvegicus	98-103
30108502-6	2018	By increasing the accumulation of HIF-2alpha protein and reducing the expression of NF-kappaB and GATA2 as well as pro-inflammatory cytokines, ASP stimulated both renal and hepatic EPO production, and resulted in an elevation of serum EPO.	Aspartic Acid	143-146	erythropoietin	Rattus norvegicus	181-184
30108502-6	2018	By increasing the accumulation of HIF-2alpha protein and reducing the expression of NF-kappaB and GATA2 as well as pro-inflammatory cytokines, ASP stimulated both renal and hepatic EPO production, and resulted in an elevation of serum EPO.	Aspartic Acid	143-146	erythropoietin	Rattus norvegicus	235-238
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	erythropoietin	Rattus norvegicus	19-22
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	erythropoietin receptor	Rattus norvegicus	38-42
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	erythropoietin receptor	Rattus norvegicus	88-92
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	Janus kinase 2	Rattus norvegicus	104-108
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	signal transducer and activator of transcription 5A	Rattus norvegicus	109-114
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	Bcl2-like 1	Rattus norvegicus	175-181
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	erythroferrone	Rattus norvegicus	183-190
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	transferrin receptor	Rattus norvegicus	195-199
29884771-0	2018	Identification of a single aspartate residue critical for both fast and slow calcium-dependent inactivation of the human TRPML1 channel.	Aspartic Acid	27-36	mucolipin TRP cation channel 1	Homo sapiens	121-127
29959184-2	2018	PIP5K is essential for the development of the human neuronal system, which has been exemplified by a recessive genetic disorder, lethal congenital contractural syndrome type 3, caused by a single aspartate-to-asparagine mutation in the kinase domain of PIP5Kgamma.	Aspartic Acid	196-205	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	Homo sapiens	0-5
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	BCL2, apoptosis regulator	Rattus norvegicus	215-220
30108502-7	2018	The restoration of EPO production and EPOR mRNA expression with ASP treatment activated EPOR downstream JAK2/STAT5 and PI3K/Akt signaling, induced their target genes, such as Bcl-xL, Fam132b and Tfrc, and increased Bcl-2/Bax ratio in bone marrow-derived mononuclear cells of CKD rats.	Aspartic Acid	64-67	BCL2 associated X, apoptosis regulator	Rattus norvegicus	221-224
30108502-9	2018	These findings demonstrate that ASP elicits anti-anemic action by restoring EPO production and improving iron availability in the setting of CKD in rats.	Aspartic Acid	32-35	erythropoietin	Rattus norvegicus	76-79
29967150-7	2018	Alternatively, Homo sapiens AlaRS selects G:U without positive recognition and uses Asp instead to repel a competitor.	Aspartic Acid	84-87	alanyl-tRNA synthetase 1	Homo sapiens	28-33
29884771-5	2018	Here, using a mutant screening method in combination with a whole-cell patch clamp technique, we identified a key TRPML1 residue, Asp-472, responsible for both fast calcium-dependent inactivation (FCDI) and slow calcium-dependent inactivation (SCDI) as well as H+ regulation.	Aspartic Acid	130-133	mucolipin TRP cation channel 1	Homo sapiens	114-120
29915162-6	2018	The simulations suggest that the selectivity filter is formed by a cage of four aspartic acid residues (D55), contributed by four claudin-15 molecules, which creates a negative electrostatic potential to favor cation flux over anion flux.	Aspartic Acid	80-93	claudin 15	Homo sapiens	130-140
29884704-4	2018	In this article, we show multiple lines of evidence in which point mutations in aspartic acid residues in both C2 domains of human Munc13-4, whose mutation underlies familial hemophagocytic lymphohistiocytosis type 3, diminished exocytosis with dramatically altered Ca2+ sensitivity in both mouse primary NK cells as well as rat mast cell lines.	Aspartic Acid	80-93	unc-13 homolog D	Homo sapiens	131-139
29983416-5	2018	Using in silico experiments, we identified interface polar residue Asp-354 of p38 and Arg-492, Arg-496 of TRF2 as protein-protein interaction hotspots.	Aspartic Acid	67-70	mitogen-activated protein kinase 14	Homo sapiens	78-81
29983416-5	2018	Using in silico experiments, we identified interface polar residue Asp-354 of p38 and Arg-492, Arg-496 of TRF2 as protein-protein interaction hotspots.	Aspartic Acid	67-70	telomeric repeat binding factor 2	Homo sapiens	106-110
29356040-8	2018	This signal transduction was initiated by competitive binding of CD147 with integrin beta1 that interrupted the interaction between the Arg-Gly-Asp motif of fibronectin and integrin beta1.	Aspartic Acid	144-147	integrin subunit beta 1	Homo sapiens	76-90
29654977-0	2018	Identification of Isomeric Aspartate residues in betaB2-crystallin from Aged Human Lens.	Aspartic Acid	27-36	crystallin beta B2	Homo sapiens	49-66
29654977-6	2018	To solve those problems and detect the isomerization of Asp residues in lens betaB2-crystallin, the main component of the beta-crystallin family, here we have developed steps for sample fractionation before d/l analysis based on either LC-MS/MS or amino acid derivatization to diastereoisomers followed by RP-HPLC.	Aspartic Acid	56-59	crystallin beta B2	Homo sapiens	77-94
29654977-10	2018	Synthetic peptides of betaB2-crystallin containing different isomers of Asp showed differential elution profiles during RP-HPLC, indicating differences in the local structure or hydrophobicity of Asp-isomer-containing peptides.	Aspartic Acid	72-75	crystallin beta B2	Homo sapiens	22-39
29654977-10	2018	Synthetic peptides of betaB2-crystallin containing different isomers of Asp showed differential elution profiles during RP-HPLC, indicating differences in the local structure or hydrophobicity of Asp-isomer-containing peptides.	Aspartic Acid	196-199	crystallin beta B2	Homo sapiens	22-39
29356040-8	2018	This signal transduction was initiated by competitive binding of CD147 with integrin beta1 that interrupted the interaction between the Arg-Gly-Asp motif of fibronectin and integrin beta1.	Aspartic Acid	144-147	fibronectin 1	Homo sapiens	157-168
29356040-8	2018	This signal transduction was initiated by competitive binding of CD147 with integrin beta1 that interrupted the interaction between the Arg-Gly-Asp motif of fibronectin and integrin beta1.	Aspartic Acid	144-147	integrin subunit beta 1	Homo sapiens	173-187
29928391-3	2018	It was found that Cbp/p300-interacting transactivators with glutamic acid [E] and aspartic acid [D]-rich C-terminal domain 1 (CITED1) was a novel potential PTC-associated gene in thyroid cancer.	Aspartic Acid	82-95	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1	Homo sapiens	126-132
29941933-5	2018	Cell lines least sensitive to ETC inhibition maintain aspartate levels by importing it through an aspartate/glutamate transporter, SLC1A3.	Aspartic Acid	54-63	solute carrier family 1 member 3	Homo sapiens	131-137
29941933-7	2018	Interestingly, aspartate levels also decrease under low oxygen, and increasing aspartate import by SLC1A3 provides a competitive advantage to cancer cells at low oxygen levels and in tumour xenografts.	Aspartic Acid	79-88	solute carrier family 1 member 3	Homo sapiens	99-105
29712727-5	2018	Shotgun proteomic analysis of 24-h LL-37-treated hyphae revealed an increase in the abundance of proteins associated with growth (eukaryotic translation initiation factor 5A [eIF-5A] [16.3-fold increased]), tissue degradation (aspartic endopeptidase [4.7-fold increased]), and allergic reactions (Asp F13 [10-fold increased]).	Aspartic Acid	297-300	cathelicidin antimicrobial peptide	Homo sapiens	35-40
29688414-8	2018	Results indicated that addition of the E. coli phytase to the negative control diet tended to quadratically improve the apparent ileal digestibility of Phe (P = 0.086) and Asp (P = 0.054), and linearly increased (P &lt; 0.05) the apparent total tract digestibility (ATTD) of ADF, K, and Fe.	Aspartic Acid	172-175	phytase	Zea mays	47-54
30960615-4	2018	In nature, the fibronectin peptide sequence, arginine-glycine-aspartic acid (RGD) synergistically promotes the integrin alpha5beta1 mediated cell adhesion with another epitope, proline-histidine-serine-arginine-asparagine (PHSRN); however most functionalization strategies focus on RGD alone.	Aspartic Acid	62-75	fibronectin 1	Homo sapiens	15-26
29659163-2	2018	In this study, the alpha-MSH-derived peptide NAP-NS1 (Nle-Asp-His-d-Phe-Arg-Trp-Gly-NH2 ) with and without linkers was conjugated with 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid (DPA-COOH) and labeled with [99m Tc]Tc-tricarbonyl by two methods.	Aspartic Acid	58-61	proopiomelanocortin	Homo sapiens	19-28
29614254-6	2018	On the other hand, exchange of the aspartic acid for alanine and then arginine resulted in an increasingly greater bias toward protein phosphatase-1 (PP1) relative to MLCP inhibition, an outcome that resulted in increased paracellular permeability for solutes in the size range of therapeutic peptides, but with a significant increase in cytotoxicity.	Aspartic Acid	35-48	inorganic pyrophosphatase 1	Homo sapiens	127-148
29614254-6	2018	On the other hand, exchange of the aspartic acid for alanine and then arginine resulted in an increasingly greater bias toward protein phosphatase-1 (PP1) relative to MLCP inhibition, an outcome that resulted in increased paracellular permeability for solutes in the size range of therapeutic peptides, but with a significant increase in cytotoxicity.	Aspartic Acid	35-48	inorganic pyrophosphatase 1	Homo sapiens	150-153
29748115-2	2018	A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.	Aspartic Acid	106-109	KRAS proto-oncogene, GTPase	Homo sapiens	71-75
29748115-2	2018	A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.	Aspartic Acid	106-109	mitogen-activated protein kinase 1	Homo sapiens	260-264
29748115-2	2018	A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.	Aspartic Acid	106-109	mitogen-activated protein kinase 1	Homo sapiens	300-303
29775303-3	2018	Analyzing the results of a previous virtual screening against murine double minute 2 protein (MDM2), we envisaged that Arg-Gly-Asp (RGD)-mimetic molecules could be inhibitors of MDM2/4.	Aspartic Acid	127-130	transformed mouse 3T3 cell double minute 2	Mus musculus	69-92
29775303-3	2018	Analyzing the results of a previous virtual screening against murine double minute 2 protein (MDM2), we envisaged that Arg-Gly-Asp (RGD)-mimetic molecules could be inhibitors of MDM2/4.	Aspartic Acid	127-130	transformed mouse 3T3 cell double minute 2	Mus musculus	94-98
29775303-3	2018	Analyzing the results of a previous virtual screening against murine double minute 2 protein (MDM2), we envisaged that Arg-Gly-Asp (RGD)-mimetic molecules could be inhibitors of MDM2/4.	Aspartic Acid	127-130	transformed mouse 3T3 cell double minute 2	Mus musculus	178-182
29922054-5	2018	With the expression of Arg-Gly-Asp peptide in the gelatin, the TGF-beta1@MAGNCs have an inherent affinity for chondrogenic ATDC5 cells.	Aspartic Acid	31-34	transforming growth factor, beta 1	Mus musculus	63-72
29659163-2	2018	In this study, the alpha-MSH-derived peptide NAP-NS1 (Nle-Asp-His-d-Phe-Arg-Trp-Gly-NH2 ) with and without linkers was conjugated with 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid (DPA-COOH) and labeled with [99m Tc]Tc-tricarbonyl by two methods.	Aspartic Acid	58-61	influenza virus NS1A binding protein	Homo sapiens	49-52
29524392-10	2018	Thus, the oxytocin receptor is allosterically controlled by sodium similar to other GPCRs, but it behaves differently concerning the involvement of the conserved Asp 85.	Aspartic Acid	162-165	oxytocin receptor	Homo sapiens	10-27
29524392-11	2018	In case of the oxytocin receptor, Asp 85 is obviously essential for proper localization in the plasma membrane.	Aspartic Acid	34-37	oxytocin receptor	Homo sapiens	15-32
29571628-7	2018	Interestingly, the abundance of L-isoAsp is low in the water-soluble cortex despite being the dominant product generated by isomerization of Asp in vitro, suggesting that Protein L-isoaspartyl methyltransferase (PIMT) is active in the cortex and suppresses the accumulation of L-isoAsp.	Aspartic Acid	37-40	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	171-210
29571628-7	2018	Interestingly, the abundance of L-isoAsp is low in the water-soluble cortex despite being the dominant product generated by isomerization of Asp in vitro, suggesting that Protein L-isoaspartyl methyltransferase (PIMT) is active in the cortex and suppresses the accumulation of L-isoAsp.	Aspartic Acid	37-40	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	212-216
28604271-7	2018	The results of molecular docking revealed that in LYZ and trypsin systems, LEV bound to the active sites residues GLU 35 and ASP 52 of LYZ and trypsin at the active site SER 195, and in BHb system, LEV was located in the central cavity, which was consistent with the results of synchronous fluorescence experiment.	Aspartic Acid	125-128	lysozyme C, tracheal isozyme	Bos taurus	50-53
28604271-7	2018	The results of molecular docking revealed that in LYZ and trypsin systems, LEV bound to the active sites residues GLU 35 and ASP 52 of LYZ and trypsin at the active site SER 195, and in BHb system, LEV was located in the central cavity, which was consistent with the results of synchronous fluorescence experiment.	Aspartic Acid	125-128	lysozyme C, tracheal isozyme	Bos taurus	135-138
29534219-7	2018	The crude LDL oil of PEG precipitation was very significantly higher (P &lt; 0.01) than ammonium sulfate precipitation (ASP), while there was no significant difference in protein, which indicates that PEG can extract more crude LDL.	Aspartic Acid	120-123	progestagen associated endometrial protein	Homo sapiens	201-204
29805647-4	2018	As this residue, aspartic acid, is not a direct phosphorylation site of the protein, molecular modeling tools were used to predict the influence of these mutations on the protein structure of beta-catenin.	Aspartic Acid	17-30	catenin beta 1	Homo sapiens	192-204
29520912-0	2018	Laser ablation synthesis of arsenic-phosphide Asm Pn clusters from As-P mixtures.	Aspartic Acid	67-71	H19 imprinted maternally expressed transcript	Homo sapiens	46-49
30027060-3	2018	A metabolomics analysis of cells exposed to nanosilver (nAg) integrates volcano plots (t-tests and fold change analysis), partial least squares-discriminant analysis (PLS-DA), and significance analysis of microarrays (SAM) and identifies six metabolites (l-aspartic acid, l-malic acid, myoinositol, d-sorbitol, citric acid, and l-cysteine).	Aspartic Acid	255-270	NBAS subunit of NRZ tethering complex	Homo sapiens	56-59
29806001-5	2018	The ceramide-mediated regulation of LAPTM4B depends on a sphingolipid interaction motif and an adjacent aspartate residue in the protein"s third transmembrane (TM3) helix.	Aspartic Acid	104-113	lysosomal protein transmembrane 4 beta	Homo sapiens	36-43
29517941-8	2018	ASP exerted beneficial effects by inducing activating transcription factor 6 (ATF6) and increasing ATF6 target protein levels, which in turn attenuated ER stress and increased antioxidant activity.	Aspartic Acid	0-3	activating transcription factor 6	Rattus norvegicus	78-82
29806001-5	2018	The ceramide-mediated regulation of LAPTM4B depends on a sphingolipid interaction motif and an adjacent aspartate residue in the protein"s third transmembrane (TM3) helix.	Aspartic Acid	104-113	tropomyosin 3	Homo sapiens	160-163
29989088-8	2018	We herein report 4 novel inhibitor candidates of Asp-Ile-Phe, Asp-Ile-Tyr, Asp-Ile-Lys and Hser-Gly-Phe with high potency and selectivity binding to MMP-2, as well as 6 novel inhibitor candidates of Chg-Ile-Ile, Chg-Ile-Leu, Chg-Ile-Glu, Chg-Ile-Met, Chg-Val-Ile and Chg-Val-Leu selectively binding to MMP-7.	Aspartic Acid	49-52	matrix metallopeptidase 2	Homo sapiens	149-154
29989088-8	2018	We herein report 4 novel inhibitor candidates of Asp-Ile-Phe, Asp-Ile-Tyr, Asp-Ile-Lys and Hser-Gly-Phe with high potency and selectivity binding to MMP-2, as well as 6 novel inhibitor candidates of Chg-Ile-Ile, Chg-Ile-Leu, Chg-Ile-Glu, Chg-Ile-Met, Chg-Val-Ile and Chg-Val-Leu selectively binding to MMP-7.	Aspartic Acid	49-52	matrix metallopeptidase 7	Homo sapiens	302-307
29588365-7	2018	In return, the hydrogen atoms contributed by the side chain of Ser-261 and the main chain of Ser-263 bonded the oxygen atoms of CaV1.2 Asp-181.	Aspartic Acid	135-138	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	128-134
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Aspartic Acid	0-3	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	60-64
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Aspartic Acid	0-3	histocompatibility 3b, Th stimulating	Mus musculus	69-72
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Aspartic Acid	0-3	NLR family, apoptosis inhibitory protein 2	Mus musculus	76-81
29470850-5	2018	RESULTS: A novel glycine-to-aspartic acid substitution (G310D) in IGF1R was identified, which associated with T2D in a sex-specific manner (Psex interaction = 0.02).	Aspartic Acid	28-41	insulin like growth factor 1 receptor	Homo sapiens	66-71
29034415-5	2018	The patient was treated by insulin glargine and insulin aspartate.	Aspartic Acid	56-65	insulin	Homo sapiens	48-55
29034415-6	2018	She regularly stopped insulin glargine injections seeking the asthenia sensation produced by hyperglycemia, keeping the insulin aspartate injections to treat the disabling symptom related to hyperketonemia.	Aspartic Acid	128-137	insulin	Homo sapiens	120-127
29402466-4	2018	CTR1 from humans, primates and many other species contains the Met-Asp-His (MDH) sequence, while some rodents including mouse have the Met-Asn-His (MNH) N-terminal sequence.	Aspartic Acid	67-70	solute carrier family 31 member 1	Homo sapiens	0-4
29564502-3	2018	In the presence of 10 mM CaCl2, a current increase of up to   240% was observed, probably due to an intra-complexation reaction between Ca2+ and the aspartate/glutamate residues found at the interface between the dehydrogenase domain and the cytochrome domain of FDH.	Aspartic Acid	149-158	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	263-266
29564502-10	2018	In order to correlate the results obtained by amperometric and spectrophotometric measurements, CD experiments have been performed showing a great structural change of FDH when increasing the concentration CaCl2 up to 50 mM, at which the enzyme molecules start to agglomerate, hindering the substrate access to the active site probably due to a chelation reaction occurring at the enzyme surface with the glutamate/aspartate residues.	Aspartic Acid	415-424	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	168-171
29514829-9	2018	This was evaluated by Vmax of the OCT2-model substrate ASP+ (23.5 +- 0.1, 13.1 +- 0.3, and 21.6 +- 0.6 minutes-1 in ciPTEC-parent, ciPTEC-OAT1, and ciPTEC-OAT3, respectively).	Aspartic Acid	55-59	solute carrier family 22 member 2	Homo sapiens	34-38
29517941-8	2018	ASP exerted beneficial effects by inducing activating transcription factor 6 (ATF6) and increasing ATF6 target protein levels, which in turn attenuated ER stress and increased antioxidant activity.	Aspartic Acid	0-3	activating transcription factor 6	Rattus norvegicus	99-103
29517941-9	2018	Conclusions Our findings indicate that ASP, a major water-soluble component of A. sinensis, exerts protective effects against H2O2-induced injury in H9c2 cells by activating the ATF6 pathway, thus ameliorating ER and oxidative stress.	Aspartic Acid	39-42	activating transcription factor 6	Rattus norvegicus	178-182
29535152-7	2018	Point mutations within this region highlighted the contribution of a P2X7R-specific aspartic acid residue (D280) that modeling suggests forms a salt bridge with the lower body region of the receptor.	Aspartic Acid	84-97	purinergic receptor P2X 7	Homo sapiens	69-74
29287449-5	2018	The antioxidant capacity and the alpha-glucosidase inhibitory activity of the duodenal extract correlated with the amount of ASP in the bread.	Aspartic Acid	125-128	sucrase-isomaltase	Homo sapiens	33-50
29520959-6	2018	Some C4 acids follow a secondary decarboxylation route, which is obligatory, in the form of "aspartate-malate", for the NADP-ME subtype, but facultative, in the form of phosphoenolpyruvate-carboxykinase (PEP-CK), for the NAD-ME subtype.	Aspartic Acid	93-102	malic enzyme 1	Homo sapiens	120-127
29636417-4	2018	This residue, located at "canonical" position 255, where it is Ile in human pancreatic carboxypeptidases A1 (hCPA1) and A2 (hCPA2) and Asp in B (hCPB), plays a dominant role in determining the preference of hCPO for acidic C-t residues.	Aspartic Acid	135-138	carboxypeptidase A1	Homo sapiens	109-114
29636417-4	2018	This residue, located at "canonical" position 255, where it is Ile in human pancreatic carboxypeptidases A1 (hCPA1) and A2 (hCPA2) and Asp in B (hCPB), plays a dominant role in determining the preference of hCPO for acidic C-t residues.	Aspartic Acid	135-138	carboxypeptidase A2	Homo sapiens	124-129
29636417-4	2018	This residue, located at "canonical" position 255, where it is Ile in human pancreatic carboxypeptidases A1 (hCPA1) and A2 (hCPA2) and Asp in B (hCPB), plays a dominant role in determining the preference of hCPO for acidic C-t residues.	Aspartic Acid	135-138	carboxypeptidase O	Homo sapiens	207-211
29636417-7	2018	hCPO also shows a preference for Glu over Asp, probably as a consequence of a tighter fitting of the Glu side chain in its S1" substrate-binding pocket.	Aspartic Acid	42-45	carboxypeptidase O	Homo sapiens	0-4
29499271-3	2018	Actually, the 15 mM KCl-evoked [3H]D-Asp exocytosis from spinal cord synaptosomes was reduced by the 5-HT2A agonist (+-)DOI, an effect reversed by the 5-HT2A antagonists MDL11,939, MDL100907, ketanserin and trazodone (TZD).	Aspartic Acid	37-40	5-hydroxytryptamine receptor 2A	Rattus norvegicus	101-107
29499271-3	2018	Actually, the 15 mM KCl-evoked [3H]D-Asp exocytosis from spinal cord synaptosomes was reduced by the 5-HT2A agonist (+-)DOI, an effect reversed by the 5-HT2A antagonists MDL11,939, MDL100907, ketanserin and trazodone (TZD).	Aspartic Acid	37-40	5-hydroxytryptamine receptor 2A	Rattus norvegicus	151-157
29430769-7	2018	Moreover, exchange of various surface residues of SPIp for arginine and glutamate/aspartate outside the glutamine donor region influences the efficiency of modification by MTG.	Aspartic Acid	82-91	serine protease 3	Homo sapiens	172-175
29666362-4	2018	By 13C- and 15N-tracing of glutamine metabolism and metabolite rescue experiments, we demonstrate that GOT2 provides aspartate and nucleotides to cells with activated or aberrant Jak/STAT and NF-kappaB signaling.	Aspartic Acid	117-126	glutamic-oxaloacetic transaminase 2	Homo sapiens	103-107
29662311-4	2018	Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit.	Aspartic Acid	261-270	fibrinogen beta chain	Homo sapiens	113-123
29502412-0	2018	Experimental and Theoretical Investigations of Infrared Multiple Photon Dissociation Spectra of Aspartic Acid Complexes with Zn2+ and Cd2.	Aspartic Acid	96-109	CD2 molecule	Homo sapiens	134-137
29502412-1	2018	Complexes of aspartic acid (Asp) cationized with Zn2+: Zn(Asp-H)+, Zn(Asp-H)+(ACN) where ACN = acetonitrile, and Zn(Asp-H)+(Asp); as well as with Cd2+, CdCl+(Asp), were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light generated from a free electron laser.	Aspartic Acid	13-26	CD2 molecule	Homo sapiens	146-149
29502412-1	2018	Complexes of aspartic acid (Asp) cationized with Zn2+: Zn(Asp-H)+, Zn(Asp-H)+(ACN) where ACN = acetonitrile, and Zn(Asp-H)+(Asp); as well as with Cd2+, CdCl+(Asp), were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light generated from a free electron laser.	Aspartic Acid	28-31	CD2 molecule	Homo sapiens	146-149
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Aspartic Acid	29-32	immunoglobulin kappa variable 1-16	Homo sapiens	47-50
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Aspartic Acid	29-32	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Aspartic Acid	29-32	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Aspartic Acid	29-32	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29557460-6	2018	When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1, the concentration of As(iii) in the aqueous solution could be reduced from 2 mg L-1 to below 10 mug L-1.When Mg-Zn-Fe-Asp-LDH was applied in practical water samples with a dosage of 0.2 g L-1, the residual concentrations of arsenic in three actual water samples were all lower than 10 mug L-1 after adsorption.	Aspartic Acid	29-32	immunoglobulin kappa variable 1-16	Homo sapiens	132-135
29440254-4	2018	M. maripaludis MMP0739, which is annotated as an aspartate/glutamate racemase, complemented a ridA mutant strain and reduced the intracellular 2AA burden.	Aspartic Acid	49-58	reactive intermediate imine deaminase A homolog	Homo sapiens	94-98
29440254-5	2018	The aspartate/glutamate racemase YgeA from Escherichia coli or S. enterica, when provided in trans, similarly restored wild-type growth to a ridA mutant.	Aspartic Acid	4-13	reactive intermediate imine deaminase A homolog	Homo sapiens	141-145
32254364-4	2018	In this work, inspired by the statherin in the salivary acquired pellicle, we designed a simple peptide sequence, Asp-Asp-Asp-Glu-Glu-Lys-Cys (peptide-7), to accomplish the dual tasks of adsorption and mineralization on enamel surfaces.	Aspartic Acid	114-117	statherin	Homo sapiens	30-39
29662311-4	2018	Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit.	Aspartic Acid	261-270	fibrinogen beta chain	Homo sapiens	175-185
29662311-4	2018	Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit.	Aspartic Acid	261-270	fibrinogen beta chain	Homo sapiens	175-185
29351412-4	2018	In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA).The integrin/focal adhesion kinase (FAK) signaling pathway mediates this effect, since CTGF expression is abolished by the use of the Arg-Gly-Asp-Ser peptide and also by an inhibitor of FAK autophosphorylation at tyrosine 397.	Aspartic Acid	284-287	cellular communication network factor 2	Mus musculus	94-98
29351412-4	2018	In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA).The integrin/focal adhesion kinase (FAK) signaling pathway mediates this effect, since CTGF expression is abolished by the use of the Arg-Gly-Asp-Ser peptide and also by an inhibitor of FAK autophosphorylation at tyrosine 397.	Aspartic Acid	284-287	PTK2 protein tyrosine kinase 2	Mus musculus	146-176
29351412-4	2018	In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA).The integrin/focal adhesion kinase (FAK) signaling pathway mediates this effect, since CTGF expression is abolished by the use of the Arg-Gly-Asp-Ser peptide and also by an inhibitor of FAK autophosphorylation at tyrosine 397.	Aspartic Acid	284-287	PTK2 protein tyrosine kinase 2	Mus musculus	178-181
29395469-1	2018	OBJECTIVE: Eight repetitive nucleotide sequences of aspartate-serine-serine (8DSS) derived from dentin phosphoprotein (DPP) has been proved to be a good remineralization agency.	Aspartic Acid	52-61	dentin sialophosphoprotein	Homo sapiens	96-117
29382726-6	2018	We found that OTUB1 directly interacted with DEPTOR via its N-terminal domain, deubiquitinated DEPTOR, and thereby stabilized DEPTOR in a Cys-91-independent but Asp-88-dependent manner, suggesting that OTUB1 targets DEPTOR for deubiquitination via a deubiquitinase activity-independent non-canonical mechanism.	Aspartic Acid	161-164	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	14-19
29476645-0	2018	Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity.	Aspartic Acid	50-53	angiotensin I converting enzyme	Homo sapiens	76-79
29476645-8	2018	DATABASE: The atomic coordinates and structure factors for N- and C-domains of ACE bound to sampatrilat and sampatrilat-Asp complexes (6F9V, 6F9R, 6F9T and 6F9U respectively) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).	Aspartic Acid	120-123	angiotensin I converting enzyme	Homo sapiens	79-82
29382726-6	2018	We found that OTUB1 directly interacted with DEPTOR via its N-terminal domain, deubiquitinated DEPTOR, and thereby stabilized DEPTOR in a Cys-91-independent but Asp-88-dependent manner, suggesting that OTUB1 targets DEPTOR for deubiquitination via a deubiquitinase activity-independent non-canonical mechanism.	Aspartic Acid	161-164	DEP domain containing MTOR interacting protein	Homo sapiens	45-51
29462789-6	2018	hFEN1 residues with distinct roles in the catalytic mechanism, including those binding metal ions (Asp-34 and Asp-181), steering the 5"-flap through the active site and binding the scissile phosphate (Lys-93 and Arg-100), and stacking against the base 5" to the scissile phosphate (Tyr-40), all contribute to these rate-limiting conformational changes, ensuring efficient and specific cleavage of 5"-flaps.	Aspartic Acid	99-102	flap structure-specific endonuclease 1	Homo sapiens	0-5
29462789-6	2018	hFEN1 residues with distinct roles in the catalytic mechanism, including those binding metal ions (Asp-34 and Asp-181), steering the 5"-flap through the active site and binding the scissile phosphate (Lys-93 and Arg-100), and stacking against the base 5" to the scissile phosphate (Tyr-40), all contribute to these rate-limiting conformational changes, ensuring efficient and specific cleavage of 5"-flaps.	Aspartic Acid	110-113	flap structure-specific endonuclease 1	Homo sapiens	0-5
29271628-3	2018	Herein, we designed a stabilized peptide-based proteolysis-targeting chimera (PROTAC) targeting estrogen receptor alpha (ERalpha) by tethering an N-terminal aspartic acid cross-linked stabilized peptide ERalpha modulator (TD-PERM) with a pentapeptide that binds the Von Hippel-Lindau (VHL) E3 ubiquitin ligase complex.	Aspartic Acid	157-170	estrogen receptor 1 (alpha)	Mus musculus	96-119
29508879-3	2018	The conventionally accepted mechanism is that both steps are concerted processes involving acid-base catalysis from a nearby aspartate (D10) side chain.	Aspartic Acid	125-134	CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion	Homo sapiens	136-139
29558951-5	2018	HM-3, an antitumor peptide including an Arg-Gly-Asp sequence, can specifically target integrin alphavbeta3 that is presented on some tumor cells.	Aspartic Acid	48-51	integrin subunit alpha V	Homo sapiens	86-106
29397068-5	2018	His-7, Glu-9 and Asp-15 of GLP-1 act together to destabilise transmembrane helix 6 and extracellular loop 3 in order to generate an active conformation of GLP-1R.	Aspartic Acid	17-20	glucagon	Homo sapiens	27-32
29397068-5	2018	His-7, Glu-9 and Asp-15 of GLP-1 act together to destabilise transmembrane helix 6 and extracellular loop 3 in order to generate an active conformation of GLP-1R.	Aspartic Acid	17-20	glucagon like peptide 1 receptor	Homo sapiens	155-161
29615866-3	2018	One of these enzymes is the aspartyl-tRNA synthetase DARS, which pairs aspartate with its corresponding tRNA.	Aspartic Acid	71-80	aspartyl-tRNA synthetase 1	Homo sapiens	53-57
29271628-3	2018	Herein, we designed a stabilized peptide-based proteolysis-targeting chimera (PROTAC) targeting estrogen receptor alpha (ERalpha) by tethering an N-terminal aspartic acid cross-linked stabilized peptide ERalpha modulator (TD-PERM) with a pentapeptide that binds the Von Hippel-Lindau (VHL) E3 ubiquitin ligase complex.	Aspartic Acid	157-170	estrogen receptor 1 (alpha)	Mus musculus	121-128
29271628-3	2018	Herein, we designed a stabilized peptide-based proteolysis-targeting chimera (PROTAC) targeting estrogen receptor alpha (ERalpha) by tethering an N-terminal aspartic acid cross-linked stabilized peptide ERalpha modulator (TD-PERM) with a pentapeptide that binds the Von Hippel-Lindau (VHL) E3 ubiquitin ligase complex.	Aspartic Acid	157-170	estrogen receptor 1 (alpha)	Mus musculus	203-210
29360343-2	2018	Specifically, we genetically encoded a thioester-activated aspartic acid (ThioD) in bacteria in good yield and with high fidelity using an orthogonal nonsense suppressor tRNA/aminoacyl-tRNA synthetase (aaRS) pair.	Aspartic Acid	59-72	alanyl-tRNA synthetase 1	Homo sapiens	170-200
29371401-7	2018	The aspartate/glutamate heteroexchange mediated by AtUCP1 and AtUCP2 is electroneutral, in contrast to that mediated by the mammalian mitochondrial aspartate glutamate carrier.	Aspartic Acid	4-13	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	51-57
29360343-2	2018	Specifically, we genetically encoded a thioester-activated aspartic acid (ThioD) in bacteria in good yield and with high fidelity using an orthogonal nonsense suppressor tRNA/aminoacyl-tRNA synthetase (aaRS) pair.	Aspartic Acid	59-72	alanyl-tRNA synthetase 1	Homo sapiens	202-206
29271628-3	2018	Herein, we designed a stabilized peptide-based proteolysis-targeting chimera (PROTAC) targeting estrogen receptor alpha (ERalpha) by tethering an N-terminal aspartic acid cross-linked stabilized peptide ERalpha modulator (TD-PERM) with a pentapeptide that binds the Von Hippel-Lindau (VHL) E3 ubiquitin ligase complex.	Aspartic Acid	157-170	von Hippel-Lindau tumor suppressor	Mus musculus	266-283
29371401-0	2018	Uncoupling proteins 1 and 2 (UCP1 and UCP2) from Arabidopsis thaliana are mitochondrial transporters of aspartate, glutamate, and dicarboxylates.	Aspartic Acid	104-113	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	0-27
29371401-7	2018	The aspartate/glutamate heteroexchange mediated by AtUCP1 and AtUCP2 is electroneutral, in contrast to that mediated by the mammalian mitochondrial aspartate glutamate carrier.	Aspartic Acid	4-13	uncoupling protein 2	Arabidopsis thaliana	62-68
29371401-7	2018	The aspartate/glutamate heteroexchange mediated by AtUCP1 and AtUCP2 is electroneutral, in contrast to that mediated by the mammalian mitochondrial aspartate glutamate carrier.	Aspartic Acid	148-157	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	51-57
29371401-0	2018	Uncoupling proteins 1 and 2 (UCP1 and UCP2) from Arabidopsis thaliana are mitochondrial transporters of aspartate, glutamate, and dicarboxylates.	Aspartic Acid	104-113	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	29-33
29371401-7	2018	The aspartate/glutamate heteroexchange mediated by AtUCP1 and AtUCP2 is electroneutral, in contrast to that mediated by the mammalian mitochondrial aspartate glutamate carrier.	Aspartic Acid	148-157	uncoupling protein 2	Arabidopsis thaliana	62-68
29429936-4	2018	Mutating lysine at position 10 or lysine at position 11 of PSD-95 to glutamate, or glutamate at position 53 or glutamate and aspartate at positions 213 and 217 of alpha-actinin, respectively, to lysine impairs, in parallel, PSD-95 binding to alpha-actinin and postsynaptic localization of PSD-95 and AMPARs.	Aspartic Acid	125-134	actinin alpha 1	Homo sapiens	163-176
29371401-10	2018	Notably, AtUCP1 and AtUCP2 are the first reported mitochondrial carriers in Arabidopsis to transport aspartate and glutamate.	Aspartic Acid	101-110	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	9-15
29371401-10	2018	Notably, AtUCP1 and AtUCP2 are the first reported mitochondrial carriers in Arabidopsis to transport aspartate and glutamate.	Aspartic Acid	101-110	uncoupling protein 2	Arabidopsis thaliana	20-26
29371401-0	2018	Uncoupling proteins 1 and 2 (UCP1 and UCP2) from Arabidopsis thaliana are mitochondrial transporters of aspartate, glutamate, and dicarboxylates.	Aspartic Acid	104-113	uncoupling protein 2	Arabidopsis thaliana	38-42
29456021-2	2018	ASPA encodes aspartoacylase, an oligodendroglial enzyme that cleaves the abundant brain amino acid N-acetyl-L-aspartate (NAA) to L-aspartate and acetate.	Aspartic Acid	108-119	aspartoacylase	Mus musculus	0-4
29284690-12	2018	Finally, Ala mutation of PINK1 at Ser495 partially suppressed AMPKalpha2 overexpression-induced mitophagy and improvement of mitochondrial function in phenylephrine-stimulated cardiomyocytes, whereas Asp (phosphorylation mimic) mutation promoted mitophagy after phenylephrine stimulation.	Aspartic Acid	200-203	PTEN induced putative kinase 1	Mus musculus	25-30
29561445-0	2018	Association of aspartic acid repeat polymorphism in the asporin gene with osteoarthritis of knee, hip, and hand: A PRISMA-compliant meta-analysis.	Aspartic Acid	15-28	asporin	Homo sapiens	56-63
29426960-8	2018	The mutation G659D is in the SH3 (Src homology 3) domain of CASK, replacing a semi-conserved glycine with aspartate.	Aspartic Acid	106-115	calcium/calmodulin dependent serine protein kinase	Homo sapiens	60-64
28513838-2	2018	NPNT protein belongs to the epidermal growth factor (EGF)-like superfamily and exhibits several common structural determinants; including EGF-like repeat domains, MAM domain (Meprin, A5 Protein, and Receptor Protein-Tyrosine Phosphatase micro), RGD motif (Arg-Gly-Asp) and a coiled-coil domain.	Aspartic Acid	264-267	nephronectin	Homo sapiens	0-4
29331980-7	2018	The identified missense mutation resulted in the substitution of a conserved aspartic residue with asparaginate in the modified H3TH motif of DMC1.	Aspartic Acid	99-111	DNA meiotic recombinase 1	Homo sapiens	142-146
29353375-7	2018	Furthermore, a specific inhibitor of inducible NOS (iNOS), aminoguanidine (10 microM) blocked the inhibitory action of L-cysteine on K+-evoked [3H]D-aspartate release.	Aspartic Acid	149-158	nitric oxide synthase 2	Bos taurus	37-50
29353375-7	2018	Furthermore, a specific inhibitor of inducible NOS (iNOS), aminoguanidine (10 microM) blocked the inhibitory action of L-cysteine on K+-evoked [3H]D-aspartate release.	Aspartic Acid	149-158	nitric oxide synthase 2	Bos taurus	52-56
29193371-6	2018	Using peptide-based polyRGG substrates and a novel 2-hybrid binding assay, we find that the Asp residue in YGGDR(S/G)G repeats confers poor binding to PRMT1.	Aspartic Acid	92-95	protein arginine methyltransferase 1	Homo sapiens	151-156
29203644-3	2018	Here, we identify the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a potent repressor of macrophage proinflammatory activation.	Aspartic Acid	77-90	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	124-130
29480802-5	2018	In the absence of HPF1, glutamate/aspartate becomes the main target residues for ADPr.	Aspartic Acid	34-43	histone PARylation factor 1	Homo sapiens	18-22
29203644-3	2018	Here, we identify the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a potent repressor of macrophage proinflammatory activation.	Aspartic Acid	77-90	CREB binding protein	Homo sapiens	22-30
28850807-1	2018	Milk-fat globule epidermal growth factor (EGF) 8 protein (MFGE8), also known as lactadherin, promotes cell adhesion in an Arg-Gly-Asp (RGD)-dependent modus via integrins.	Aspartic Acid	130-133	lactadherin	Equus caballus	58-63
29379909-1	2018	We use 2D UV-MS cold-ion spectroscopy for the identification of l-Asp, d-Asp, l-isoAsp and d-isoAsp residues in a fragment peptide derived from the hormone protein amylin.	Aspartic Acid	64-69	islet amyloid polypeptide	Homo sapiens	164-170
28278764-5	2018	Using circular dichroism (CD) spectroscopy and changing the possible salt-bridging residues to new combinations of Lys, Arg, Glu, and Asp, we found that our most helical improvements came from the Arg-Glu combination, whereas the Lys-Asp was not significantly different from the Lys-Glu of the parent scaffold, PT3.	Aspartic Acid	134-137	zinc finger protein 135	Homo sapiens	311-314
29150896-4	2018	The stereospecific effect in CID of the trans-cO residue is explained by syn-facially directed proton transfer from the 4-ammonium group at cO to the C-terminal amide followed by neighboring group participation in the cleavage of the CO-NH bond, analogous to the aspartic acid and ornithine effects.	Aspartic Acid	263-276	synemin	Homo sapiens	73-76
29214688-2	2018	CCl4 administration elevated serum aspartate and alanine transaminases levels, respectively.	Aspartic Acid	35-44	chemokine (C-C motif) ligand 4	Mus musculus	0-4
30226068-7	2018	The mutation resulted in the insertion of aspartic acid (Asp, D) in the amino acid sequence of the PCLO protein.	Aspartic Acid	42-55	piccolo presynaptic cytomatrix protein	Homo sapiens	99-103
29305262-0	2018	Point mutation of a conserved aspartate, D69, in the muscarinic M2 receptor does not modify voltage-sensitive agonist potency.	Aspartic Acid	30-39	cholinergic receptor muscarinic 2	Homo sapiens	53-75
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Aspartic Acid	168-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Aspartic Acid	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Aspartic Acid	186-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29440987-8	2018	Metabolite changes in SIRT5-/- coincided with alterations in expression of amino acid (SLC7A5, SLC7A7) and glutamate (EAAT2) transport proteins as well as key enzymes in purine (PRPS1, PPAT), fatty acid (ACADS, HADHB), glutamine-glutamate (GAD1, GLUD1), and malate-aspartate shuttle (MDH1) metabolic pathways.	Aspartic Acid	265-274	sirtuin 5	Mus musculus	22-27
29278705-1	2018	Tryptophan-aspartic acid (WD) repeat-containing protein 34 (WDR34), one of the WDR protein superfamilies with five WD40 domains, inhibits a transforming growth factor-beta (TGF-beta) activated kinase 1 (TAK1)-associated NF-kappaB activation pathway.	Aspartic Acid	11-24	dynein 2 intermediate chain 2	Homo sapiens	60-65
29278705-1	2018	Tryptophan-aspartic acid (WD) repeat-containing protein 34 (WDR34), one of the WDR protein superfamilies with five WD40 domains, inhibits a transforming growth factor-beta (TGF-beta) activated kinase 1 (TAK1)-associated NF-kappaB activation pathway.	Aspartic Acid	11-24	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	173-201
29278705-1	2018	Tryptophan-aspartic acid (WD) repeat-containing protein 34 (WDR34), one of the WDR protein superfamilies with five WD40 domains, inhibits a transforming growth factor-beta (TGF-beta) activated kinase 1 (TAK1)-associated NF-kappaB activation pathway.	Aspartic Acid	11-24	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	203-207
29379512-12	2017	The heterologously expressed TaASN1 and TaASN2 proteins were found to be active asparagine synthetases, producing asparagine and glutamate from glutamine and aspartate.	Aspartic Acid	158-167	asparagine synthetase [glutamine-hydrolyzing]	Triticum aestivum	29-35
29258289-5	2018	Corroborating electrophysiological results, these structures demonstrated that the Ca2+ selectivity of TRPV6 arises from a ring of aspartate side chains in the selectivity filter that binds Ca2+ tightly.	Aspartic Acid	131-140	transient receptor potential cation channel subfamily V member 6	Homo sapiens	103-108
30226068-7	2018	The mutation resulted in the insertion of aspartic acid (Asp, D) in the amino acid sequence of the PCLO protein.	Aspartic Acid	57-60	piccolo presynaptic cytomatrix protein	Homo sapiens	99-103
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	58-61	Cyclin-dependent kinase 4	Drosophila melanogaster	16-19
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	58-61	brahma	Drosophila melanogaster	49-52
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	58-61	brahma	Drosophila melanogaster	54-57
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	58-61	Cyclin-dependent kinase 4	Drosophila melanogaster	81-84
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	58-61	brahma	Drosophila melanogaster	153-156
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	119-122	Cyclin-dependent kinase 4	Drosophila melanogaster	16-19
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	119-122	brahma	Drosophila melanogaster	49-52
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	119-122	brahma	Drosophila melanogaster	54-57
29963966-7	2018	Expression of a CDK-site phospho-mimic mutant of Brm, brm-ASP (all the potential CDK sites are mutated from Ser/Thr to Asp), which acts genetically as a brm loss-of-function allele, dominantly accelerates progression into the S phase, and bypasses a Retinoblastoma-induced developmental G1 phase arrest in the wing epithelium.	Aspartic Acid	119-122	brahma	Drosophila melanogaster	153-156
29175998-7	2017	Unexpectedly, we find that loop-2 is sensitive to aspartate substitutions that impair Hsp104 function and abolish protein disaggregation when loop-2 is replaced by four aspartate residues.	Aspartic Acid	50-59	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	86-92
29843136-4	2018	In the present study, we aimed to investigate the ability of angelica sinensis polysaccharide (ASP) to decrease iron burden in tumor-bearing mice and the mechanism of ASP regulation hepcidin expression.	Aspartic Acid	167-170	hepcidin antimicrobial peptide	Mus musculus	182-190
29843136-9	2018	In vivo experiments also showed that ASP could potently regulate hepcidin expression in liver and serum and decrease iron burden in liver, spleen and grafted tumors in mouse model.	Aspartic Acid	37-40	hepcidin antimicrobial peptide	Mus musculus	65-73
29843136-10	2018	Treatment with ASP in hepatic cell lines reproduced comparable results in decreasing hepcidin as in mouse liver.	Aspartic Acid	15-18	hepcidin antimicrobial peptide	Mus musculus	85-93
29843136-11	2018	Furthermore, we found that ASP markedly suppressed the expression of interleukin-6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.	Aspartic Acid	27-30	interleukin 6	Mus musculus	69-82
29843136-11	2018	Furthermore, we found that ASP markedly suppressed the expression of interleukin-6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.	Aspartic Acid	27-30	interleukin 6	Mus musculus	84-88
29843136-11	2018	Furthermore, we found that ASP markedly suppressed the expression of interleukin-6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.	Aspartic Acid	27-30	Janus kinase 2	Mus musculus	91-95
29843136-11	2018	Furthermore, we found that ASP markedly suppressed the expression of interleukin-6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.	Aspartic Acid	27-30	signal transducer and activator of transcription 3	Mus musculus	99-104
29843136-11	2018	Furthermore, we found that ASP markedly suppressed the expression of interleukin-6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.	Aspartic Acid	27-30	SMAD family member 1	Mus musculus	112-119
29843136-11	2018	Furthermore, we found that ASP markedly suppressed the expression of interleukin-6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.	Aspartic Acid	27-30	SMAD family member 1	Mus musculus	112-116
29843136-11	2018	Furthermore, we found that ASP markedly suppressed the expression of interleukin-6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.	Aspartic Acid	27-30	hepcidin antimicrobial peptide	Mus musculus	214-222
28884509-1	2018	We developed a novel BMP2-mimicking peptide P28, which possesses two distinct special structural elements-seven repetitive aspartic acids and phosphorylated serine designed to promote affinity to hydroxyapatite as well as nucleation of apatite crystallization and mineralization.	Aspartic Acid	123-137	bone morphogenetic protein 2	Mus musculus	21-25
28884509-1	2018	We developed a novel BMP2-mimicking peptide P28, which possesses two distinct special structural elements-seven repetitive aspartic acids and phosphorylated serine designed to promote affinity to hydroxyapatite as well as nucleation of apatite crystallization and mineralization.	Aspartic Acid	123-137	B cell receptor associated protein 31	Mus musculus	44-47
28803402-6	2018	The inhibition of actin dynamics by treatment with latrunculin B or jasplakinolide and the disruption of the adhesion between the PM and the CW by treatment with RGDS peptide (Arg-Gly-Asp-Ser) enhanced guard cell plasmolysis.	Aspartic Acid	184-187	ral guanine nucleotide dissociation stimulator	Homo sapiens	162-166
29274147-4	2017	Mutating Ca2+-coordinating aspartates in the C2A-domain localizes Doc2B permanently at the plasma membrane, and renders an upstream priming step Ca2+-independent, whereas a separate function in downstream priming depends on SNARE-binding, Ca2+-binding to the C2B-domain of Doc2B, interaction with ubMunc13-2 and the presence of synaptotagmin-1.	Aspartic Acid	27-37	double C2, beta	Mus musculus	66-71
29274147-4	2017	Mutating Ca2+-coordinating aspartates in the C2A-domain localizes Doc2B permanently at the plasma membrane, and renders an upstream priming step Ca2+-independent, whereas a separate function in downstream priming depends on SNARE-binding, Ca2+-binding to the C2B-domain of Doc2B, interaction with ubMunc13-2 and the presence of synaptotagmin-1.	Aspartic Acid	27-37	double C2, beta	Mus musculus	273-278
29274147-4	2017	Mutating Ca2+-coordinating aspartates in the C2A-domain localizes Doc2B permanently at the plasma membrane, and renders an upstream priming step Ca2+-independent, whereas a separate function in downstream priming depends on SNARE-binding, Ca2+-binding to the C2B-domain of Doc2B, interaction with ubMunc13-2 and the presence of synaptotagmin-1.	Aspartic Acid	27-37	synaptotagmin I	Mus musculus	328-343
29843136-13	2018	CONCLUSION: The present study provides new evidence that ASP decreases hepcidin expression, which can reduce iron burden and inhibit tumor proliferation.	Aspartic Acid	57-60	hepcidin antimicrobial peptide	Mus musculus	71-79
29113979-9	2018	Substitution of the basic amino acid repeats in the Ure2 relief sequence or phosphomimetic aspartate substitutions for the serine residues between them abolishes nuclear Gln3-Myc13 localization in response to both limiting nitrogen and rapamycin treatment.	Aspartic Acid	91-100	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	170-174
29541386-4	2018	Cleavage occurs after Asp-404 in a DYSD/K sequence and separates the kinase domain from the two PBDs of Plk1.	Aspartic Acid	22-25	polo like kinase 1	Homo sapiens	104-108
29175998-7	2017	Unexpectedly, we find that loop-2 is sensitive to aspartate substitutions that impair Hsp104 function and abolish protein disaggregation when loop-2 is replaced by four aspartate residues.	Aspartic Acid	169-178	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	86-92
29312937-6	2017	Based on their catalytic active site residue, the 15 human cathepsins identified up to now are classified in three different families: serine (cathepsins A and G), aspartate (cathepsins D and E), or cysteine (cathepsins B, C, F, H, K, L, O, S, V, X, and W) proteases.	Aspartic Acid	164-173	cathepsin D	Homo sapiens	175-255
29464059-7	2018	Finally, we perform analysis of SDHC synthetic lethality with lactate dehydrogenase A (LDHA) and pyruvate carboxylase (PCX), which are important for regeneration of NAD+ and aspartate biosynthesis, respectively.	Aspartic Acid	174-183	succinate dehydrogenase complex, subunit C, integral membrane protein	Mus musculus	32-36
29464059-7	2018	Finally, we perform analysis of SDHC synthetic lethality with lactate dehydrogenase A (LDHA) and pyruvate carboxylase (PCX), which are important for regeneration of NAD+ and aspartate biosynthesis, respectively.	Aspartic Acid	174-183	lactate dehydrogenase A	Mus musculus	62-85
29464059-7	2018	Finally, we perform analysis of SDHC synthetic lethality with lactate dehydrogenase A (LDHA) and pyruvate carboxylase (PCX), which are important for regeneration of NAD+ and aspartate biosynthesis, respectively.	Aspartic Acid	174-183	lactate dehydrogenase A	Mus musculus	87-91
29464059-7	2018	Finally, we perform analysis of SDHC synthetic lethality with lactate dehydrogenase A (LDHA) and pyruvate carboxylase (PCX), which are important for regeneration of NAD+ and aspartate biosynthesis, respectively.	Aspartic Acid	174-183	pyruvate carboxylase	Mus musculus	97-117
29464059-7	2018	Finally, we perform analysis of SDHC synthetic lethality with lactate dehydrogenase A (LDHA) and pyruvate carboxylase (PCX), which are important for regeneration of NAD+ and aspartate biosynthesis, respectively.	Aspartic Acid	174-183	pyruvate carboxylase	Mus musculus	119-122
29084849-1	2017	Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction.	Aspartic Acid	38-47	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
29190078-2	2017	The canonical peptides are Gly-His-Lys and Asp-Ala-His-Lys (from the wound healing factor and human serum albumin, respectively).	Aspartic Acid	43-46	albumin	Homo sapiens	100-113
29093024-2	2017	Two tryptophan- and aspartic acid-containing (WD) motifs located in its cytoplasmic domain directly bind the tetratricopeptide repeat (TPR) motifs of the kinesin light chain (KLC), which activate kinesin-1 and recruit kinesin-1 to Alcalpha cargo.	Aspartic Acid	20-33	calsyntenin 1	Homo sapiens	231-239
29084849-1	2017	Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction.	Aspartic Acid	38-47	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
28982982-6	2017	Three aspartate residues in Cx30 (Asp-50, Asp-172, and Asp-179) have been implicated previously in the Ca2+ sensitivity of other hemichannel isoforms.	Aspartic Acid	6-15	gap junction protein beta 1 L homeolog	Xenopus laevis	28-32
28982982-6	2017	Three aspartate residues in Cx30 (Asp-50, Asp-172, and Asp-179) have been implicated previously in the Ca2+ sensitivity of other hemichannel isoforms.	Aspartic Acid	34-37	gap junction protein beta 1 L homeolog	Xenopus laevis	28-32
28982982-6	2017	Three aspartate residues in Cx30 (Asp-50, Asp-172, and Asp-179) have been implicated previously in the Ca2+ sensitivity of other hemichannel isoforms.	Aspartic Acid	42-45	gap junction protein beta 1 L homeolog	Xenopus laevis	28-32
28982982-6	2017	Three aspartate residues in Cx30 (Asp-50, Asp-172, and Asp-179) have been implicated previously in the Ca2+ sensitivity of other hemichannel isoforms.	Aspartic Acid	42-45	gap junction protein beta 1 L homeolog	Xenopus laevis	28-32
28982982-7	2017	Although the aspartate at position Asp-50 was indispensable for divalent cation-dependent gating of Cx30 hemichannels, substitutions of the two other residues had no significant effect on gating, illustrating differences in the gating mechanisms between connexin isoforms.	Aspartic Acid	13-22	gap junction protein beta 1 L homeolog	Xenopus laevis	100-104
28982982-7	2017	Although the aspartate at position Asp-50 was indispensable for divalent cation-dependent gating of Cx30 hemichannels, substitutions of the two other residues had no significant effect on gating, illustrating differences in the gating mechanisms between connexin isoforms.	Aspartic Acid	35-38	gap junction protein beta 1 L homeolog	Xenopus laevis	100-104
29203794-2	2017	Recently, it has been reported that SHATI is N-acetyltransferase 8-like protein (NAT8L) that produces N-acetylaspatate (NAA) from aspartate and acetyl-CoA.	Aspartic Acid	130-139	N-acetyltransferase 8-like	Mus musculus	36-41
29203794-2	2017	Recently, it has been reported that SHATI is N-acetyltransferase 8-like protein (NAT8L) that produces N-acetylaspatate (NAA) from aspartate and acetyl-CoA.	Aspartic Acid	130-139	N-acetyltransferase 8-like	Mus musculus	45-79
29203794-2	2017	Recently, it has been reported that SHATI is N-acetyltransferase 8-like protein (NAT8L) that produces N-acetylaspatate (NAA) from aspartate and acetyl-CoA.	Aspartic Acid	130-139	N-acetyltransferase 8-like	Mus musculus	81-86
28733903-5	2017	Meanwhile, the gene expression of IL-17 and IFN-gamma in ileum decreased in 1.0% Asp-supplemented group; the gene expression in ileum of Muc2 decreased in 0.5 and 1.0% Asp-supplemented groups.	Aspartic Acid	81-84	interleukin 17A	Mus musculus	34-39
28733903-5	2017	Meanwhile, the gene expression of IL-17 and IFN-gamma in ileum decreased in 1.0% Asp-supplemented group; the gene expression in ileum of Muc2 decreased in 0.5 and 1.0% Asp-supplemented groups.	Aspartic Acid	81-84	interferon gamma	Mus musculus	44-53
28733903-5	2017	Meanwhile, the gene expression of IL-17 and IFN-gamma in ileum decreased in 1.0% Asp-supplemented group; the gene expression in ileum of Muc2 decreased in 0.5 and 1.0% Asp-supplemented groups.	Aspartic Acid	81-84	mucin 2	Mus musculus	137-141
28733903-5	2017	Meanwhile, the gene expression of IL-17 and IFN-gamma in ileum decreased in 1.0% Asp-supplemented group; the gene expression in ileum of Muc2 decreased in 0.5 and 1.0% Asp-supplemented groups.	Aspartic Acid	168-171	interleukin 17A	Mus musculus	34-39
28733903-5	2017	Meanwhile, the gene expression of IL-17 and IFN-gamma in ileum decreased in 1.0% Asp-supplemented group; the gene expression in ileum of Muc2 decreased in 0.5 and 1.0% Asp-supplemented groups.	Aspartic Acid	168-171	mucin 2	Mus musculus	137-141
28733903-6	2017	Dietary supplementation with 2.0% Asp enhanced the expression of pIgR and Crp1 as compared to the other three groups.	Aspartic Acid	34-37	polymeric immunoglobulin receptor	Mus musculus	65-69
28733903-6	2017	Dietary supplementation with 2.0% Asp enhanced the expression of pIgR and Crp1 as compared to the other three groups.	Aspartic Acid	34-37	cysteine-rich protein 1 (intestinal)	Mus musculus	74-78
28733903-7	2017	The results indicated that dietary 1.0% Asp supplementation lowers the ratio of Firmicutes:Bacteroidetes, which affects the innate immunity by decreasing the gene expression of IL-17, IFN-gamma, and Muc2 in ileum.	Aspartic Acid	40-43	interleukin 17A	Mus musculus	177-182
28733903-7	2017	The results indicated that dietary 1.0% Asp supplementation lowers the ratio of Firmicutes:Bacteroidetes, which affects the innate immunity by decreasing the gene expression of IL-17, IFN-gamma, and Muc2 in ileum.	Aspartic Acid	40-43	interferon gamma	Mus musculus	184-193
28733903-7	2017	The results indicated that dietary 1.0% Asp supplementation lowers the ratio of Firmicutes:Bacteroidetes, which affects the innate immunity by decreasing the gene expression of IL-17, IFN-gamma, and Muc2 in ileum.	Aspartic Acid	40-43	mucin 2	Mus musculus	199-203
28063214-3	2017	Here, we show that betaTrCP interacts with Smurf1 through the 7 x tryptophan (W) aspartic acid (D)(WD) 40 and the region homologous to the E6-AP carboxyl terminus (HECT) domains, which are the E3 ligase domains of betaTrCP and Smurf1, respectively.	Aspartic Acid	81-94	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	19-27
29020418-3	2017	Shati/Nat8l synthesizes N-acetylaspartate from L-aspartate and acetyl-coenzyme A.	Aspartic Acid	47-58	N-acetyltransferase 8-like	Mus musculus	0-5
29020418-3	2017	Shati/Nat8l synthesizes N-acetylaspartate from L-aspartate and acetyl-coenzyme A.	Aspartic Acid	47-58	N-acetyltransferase 8-like	Mus musculus	6-11
28939776-8	2017	Third, Ser-3 modification (i.e. substitution with Asp or phosphorylation) "undocks" and repositions the cofilin N terminus away from the filament axis, which compromises S3D cofilin"s ability to weaken longitudinal filament subunit interactions.	Aspartic Acid	50-53	cofilin 1	Homo sapiens	104-111
28939776-8	2017	Third, Ser-3 modification (i.e. substitution with Asp or phosphorylation) "undocks" and repositions the cofilin N terminus away from the filament axis, which compromises S3D cofilin"s ability to weaken longitudinal filament subunit interactions.	Aspartic Acid	50-53	cofilin 1	Homo sapiens	174-181
28063214-3	2017	Here, we show that betaTrCP interacts with Smurf1 through the 7 x tryptophan (W) aspartic acid (D)(WD) 40 and the region homologous to the E6-AP carboxyl terminus (HECT) domains, which are the E3 ligase domains of betaTrCP and Smurf1, respectively.	Aspartic Acid	81-94	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	43-49
29068544-2	2017	In the formation of the nanoparticles, the beta-CD/admantane inclusion complex integrates poly(2-methyl-2-oxazoline) and poly(aspartic acid) chains to form pseudoblock copolymers, followed by the coordination between carboxyl groups in P(Asp) block and cisplatin.	Aspartic Acid	238-241	beta-carotene oxygenase 1	Mus musculus	43-50
29245219-9	2017	We discovered a heterozygous substitution in STK11, c.A527G in exon 4, in the girl and her father who was also a PJS patient, and the amine acid change was an aspartic acid-glycine substitution in codon 176.	Aspartic Acid	159-172	serine/threonine kinase 11	Homo sapiens	45-50
29096248-3	2017	We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients that appeared to control the EMT (epithelial-mesenchymal transition) of cancer cells, in a process associated with miR-199a-3p.	Aspartic Acid	33-36	fibrinogen beta chain	Homo sapiens	96-106
28879565-1	2017	Aspartoacylase (ASPA) is a zinc-dependent abundant enzyme in the brain, which catalyzes the conversion of N-acetyl aspartate (NAA) into acetate and aspartate.	Aspartic Acid	115-124	aspartoacylase	Homo sapiens	0-14
28879565-1	2017	Aspartoacylase (ASPA) is a zinc-dependent abundant enzyme in the brain, which catalyzes the conversion of N-acetyl aspartate (NAA) into acetate and aspartate.	Aspartic Acid	115-124	aspartoacylase	Homo sapiens	16-20
29096248-3	2017	We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients that appeared to control the EMT (epithelial-mesenchymal transition) of cancer cells, in a process associated with miR-199a-3p.	Aspartic Acid	33-36	microRNA 199a-2	Homo sapiens	257-268
28833202-12	2017	Among other LRRC8 subunits, downregulation of LRRC8D strongly inhibited release of the uncharged osmolytes [3 H]taurine and myo-[3 H]inositol, without major impact on the simultaneously measured efflux of the charged d-[14 C]aspartate.	Aspartic Acid	225-234	leucine rich repeat containing 8 VRAC subunit D	Rattus norvegicus	46-52
29032653-3	2017	Bacterial hormone-sensitive lipases (bHSLs), which are homologous to the C-terminal domain of HSL, have alpha/beta-hydrolase fold with a catalytic triad composed of His, Asp, and Ser.	Aspartic Acid	170-173	lipase E, hormone sensitive type	Homo sapiens	38-41
29178930-4	2017	In the current study, a mouse model was generated harboring a glycine to aspartic acid residue change in the Walker A motif of the ATPase domain of Msh3.	Aspartic Acid	73-86	mutS homolog 3	Mus musculus	148-152
28937754-4	2017	A new ELP nanoparticle (ISR) was synthesized that includes the canonical integrin-targeting ligand (Arg-Gly-Asp, RGD).	Aspartic Acid	108-111	nuclear receptor subfamily 5 group A member 1	Homo sapiens	6-9
29143139-3	2017	Pretreatments with alternate soaking process (ASP) using solutions containing calcium ions and phosphate ions followed by incubation with SBF for 24 h resulted in HAp deposition on PS plates with adsorption layers of HSA, type I collagen, hen egg white lysozyme, and poly L-glutamic acid, an acidic protein analogue: the deposition behaviors were correlated with adsorption ability and charge state of proteins.	Aspartic Acid	46-49	BAG cochaperone 1	Homo sapiens	163-166
29045135-2	2017	Here, we report the co-crystal structure of a helical peptide stabilized by a N-terminal unnatural cross-linked aspartic acid (TD) in complex with the ERalpha ligand binding domain (LBD).	Aspartic Acid	112-125	estrogen receptor 1	Homo sapiens	151-158
29133864-8	2017	Decrease in malate dehydrogenase induced a reverse in the malate-aspartate shuttle, contributing to dysregulation of ATP synthesis.	Aspartic Acid	65-74	malic enzyme 1	Homo sapiens	12-32
29023793-0	2017	CrossTalk proposal: Proton permeation through HV 1 requires transient protonation of a conserved aspartate in the S1 transmembrane helix.	Aspartic Acid	97-106	hydrogen voltage gated channel 1	Homo sapiens	46-50
28924049-5	2017	Here, we show that an aspartate at position 1261 is the most critical residue of the N-terminal linker for inhibiting binding of the VWF A1 domain to GpIbalpha on platelets in blood flow.	Aspartic Acid	22-31	von Willebrand factor	Homo sapiens	133-136
28924049-5	2017	Here, we show that an aspartate at position 1261 is the most critical residue of the N-terminal linker for inhibiting binding of the VWF A1 domain to GpIbalpha on platelets in blood flow.	Aspartic Acid	22-31	glycoprotein Ib platelet subunit alpha	Homo sapiens	150-159
29116098-1	2017	In this study, we report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified polylactic acid-co-glycolic acid (PLGA)-Chitosan nanoparticle (CSNP) for integrin alphavbeta3 receptor targeted paclitaxel (PTX) delivery in lung cancer cells and its impact on normal cells.	Aspartic Acid	63-76	integrin subunit alpha V	Homo sapiens	168-188
29116025-7	2017	For in-vivo therapeutic interventions, polymeric nanoparticles of polyethylenimine-polyethylene glycol-arginine-glycine-aspartic acid were used for delivery of miR-200c mimic and inhibitor to determine the therapeutic effect of miR-200c in a rat model of endometriosis.	Aspartic Acid	120-133	microRNA 200c	Rattus norvegicus	160-168
28743075-0	2017	Preference of Arabidopsis thaliana GH3.5 acyl amido synthetase for growth versus defense hormone acyl substrates is dictated by concentration of amino acid substrate aspartate.	Aspartic Acid	166-175	Auxin-responsive GH3 family protein	Arabidopsis thaliana	35-40
29116025-7	2017	For in-vivo therapeutic interventions, polymeric nanoparticles of polyethylenimine-polyethylene glycol-arginine-glycine-aspartic acid were used for delivery of miR-200c mimic and inhibitor to determine the therapeutic effect of miR-200c in a rat model of endometriosis.	Aspartic Acid	120-133	microRNA 200c	Rattus norvegicus	228-236
28684273-2	2017	Here, we report the identification of the first avian DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41), an important DNA sensor, in chicken cells.	Aspartic Acid	60-63	DEAD-box helicase 41	Gallus gallus	97-102
28684273-2	2017	Here, we report the identification of the first avian DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41), an important DNA sensor, in chicken cells.	Aspartic Acid	72-75	DEAD-box helicase 41	Gallus gallus	97-102
28985999-0	2017	Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.	Aspartic Acid	50-59	renin	Homo sapiens	13-18
29056540-9	2017	A predictive principal components analysis model of asparaginase-associated metabolites, asparaginase-associated metabolic score (AspM), was established, including alanine, aspartate, glutamate, and succinic acid.	Aspartic Acid	173-182	assembly factor for spindle microtubules	Homo sapiens	89-128
29056540-9	2017	A predictive principal components analysis model of asparaginase-associated metabolites, asparaginase-associated metabolic score (AspM), was established, including alanine, aspartate, glutamate, and succinic acid.	Aspartic Acid	173-182	assembly factor for spindle microtubules	Homo sapiens	130-134
28731644-1	2017	HLA-A*24:198 has one nucleotide change from HLA-A*24:02:01 where aspartic acid (29) is changed to asparagine.	Aspartic Acid	65-78	major histocompatibility complex, class I, A	Homo sapiens	0-5
28731644-1	2017	HLA-A*24:198 has one nucleotide change from HLA-A*24:02:01 where aspartic acid (29) is changed to asparagine.	Aspartic Acid	65-78	major histocompatibility complex, class I, A	Homo sapiens	44-49
28796435-1	2017	HLA-DRB1*11:143 has one nucleotide change from HLA-DRB1*11:01:01 where Aspartic Acid (70) is changed to Glycine.	Aspartic Acid	71-84	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
28796435-1	2017	HLA-DRB1*11:143 has one nucleotide change from HLA-DRB1*11:01:01 where Aspartic Acid (70) is changed to Glycine.	Aspartic Acid	71-84	major histocompatibility complex, class II, DR beta 1	Homo sapiens	47-55
28743075-5	2017	Most importantly, we show that GH3.5 strongly prefers Asp as the amino acid conjugate and that the concentration of Asp dictates the functional activity of GH3.5 on IAA vs. SA.	Aspartic Acid	54-57	Auxin-responsive GH3 family protein	Arabidopsis thaliana	31-36
28743075-5	2017	Most importantly, we show that GH3.5 strongly prefers Asp as the amino acid conjugate and that the concentration of Asp dictates the functional activity of GH3.5 on IAA vs. SA.	Aspartic Acid	116-119	Auxin-responsive GH3 family protein	Arabidopsis thaliana	156-161
28743075-7	2017	During active growth, [IAA] and [Asp] are high and the catalytic efficiency (kcat/Km) of GH3.5 for IAA is 360-fold higher than with SA.	Aspartic Acid	33-36	Auxin-responsive GH3 family protein	Arabidopsis thaliana	89-94
28743075-8	2017	GH3.5 is expressed under these conditions and conversion of IAA to inactive IAA-Asp would provide fine spatial and temporal control over local auxin developmental responses.	Aspartic Acid	80-83	Auxin-responsive GH3 family protein	Arabidopsis thaliana	0-5
28743075-13	2017	Taken together, we show how GH3.5, with dual activity on IAA and SA, can integrate cellular metabolic status via Asp to provide fine control of growth vs. defense outcomes and hormone homeostasis.	Aspartic Acid	113-116	Auxin-responsive GH3 family protein	Arabidopsis thaliana	28-33
28882840-2	2017	We tested the role of phosphorylation of a GSK-3beta consensus site (S493) located in the proximal portion of the NF-H tail in NF dynamics by transfection of NB2a/d1 cells with NF-H, where S493 was mutated to aspartic acid (S493D) or to alanine (S493A) to mimic constitutive phosphorylation and non-phosphorylation.	Aspartic Acid	209-222	glycogen synthase kinase 3 beta	Mus musculus	43-52
28728943-9	2017	Mutation of Valine (V) at position 23 in Ost4p to Aspartate (D) causes defects in the N-glycosylation process.	Aspartic Acid	50-59	olichyl-diphosphooligosaccharide--protein glycotransferase OST4	Saccharomyces cerevisiae S288C	41-46
28860196-5	2017	Mutations that perturbed the conformational behavior of the beta3-alpha3 loop while keeping the active-site aspartate intact resulted in suppression of CKI1 function.	Aspartic Acid	108-117	casein kinase I	Arabidopsis thaliana	152-156
28864774-6	2017	Substitutions of CaV1.2 Asp-181 impaired the co-immunoprecipitation of CaVbeta/CaV1.2 with CaValpha2delta1 and the CaValpha2delta1-dependent shift in voltage-dependent activation gating.	Aspartic Acid	24-27	carbonic anhydrase 5B	Homo sapiens	71-78
28864774-6	2017	Substitutions of CaV1.2 Asp-181 impaired the co-immunoprecipitation of CaVbeta/CaV1.2 with CaValpha2delta1 and the CaValpha2delta1-dependent shift in voltage-dependent activation gating.	Aspartic Acid	24-27	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	79-85
28864774-10	2017	We conclude that CaV1.2 Asp-181 anchors the physical interaction that facilitates the CaValpha2delta1-mediated functional modulation of CaV1.2 currents.	Aspartic Acid	24-27	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	17-23
28864774-10	2017	We conclude that CaV1.2 Asp-181 anchors the physical interaction that facilitates the CaValpha2delta1-mediated functional modulation of CaV1.2 currents.	Aspartic Acid	24-27	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	136-142
28882840-2	2017	We tested the role of phosphorylation of a GSK-3beta consensus site (S493) located in the proximal portion of the NF-H tail in NF dynamics by transfection of NB2a/d1 cells with NF-H, where S493 was mutated to aspartic acid (S493D) or to alanine (S493A) to mimic constitutive phosphorylation and non-phosphorylation.	Aspartic Acid	209-222	neurofilament, heavy polypeptide	Mus musculus	114-118
29053416-1	2017	Integrin alphavbeta3 is a molecular marker for the estimation of tumor angiogenesis and is an imaging target for radiolabeled Arg-Gly-Asp (RGD) peptides.	Aspartic Acid	134-137	integrin subunit alpha V	Homo sapiens	0-20
28809118-5	2017	Our metabolomics analysis indicates that glutamine is the major source of oxaloacetate in S2-013.Neo and S2-013.MUC1 cells, where oxaloacetate is converted to aspartate, an important metabolite for pyrimidine nucleotide biosynthesis.	Aspartic Acid	159-168	mucin 1, cell surface associated	Homo sapiens	112-116
28809118-6	2017	However, glucose limitation impedes the flow of glutamine carbons into the pyrimidine nucleotide rings and instead leads to a significant accumulation of glutamine-derived aspartate in S2-013.MUC1 cells.	Aspartic Acid	172-181	mucin 1, cell surface associated	Homo sapiens	192-196
28816342-0	2017	Hypofibrinogenaemia associated with novel Aalpha126Val Asp mutation in the fibrinogen coiled coil.	Aspartic Acid	55-58	fibrinogen beta chain	Homo sapiens	4-14
28866798-1	2017	Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4).	Aspartic Acid	103-119	malate dehydrogenase 2	Homo sapiens	155-184
28866798-1	2017	Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4).	Aspartic Acid	103-119	malate dehydrogenase 2	Homo sapiens	186-189
28866798-1	2017	Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4).	Aspartic Acid	103-119	dihydrolipoamide dehydrogenase	Homo sapiens	208-218
28866798-1	2017	Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4).	Aspartic Acid	103-119	dihydrolipoamide dehydrogenase	Homo sapiens	220-223
28744579-2	2017	These SerRs and AspRs are not separated by their racemase functions and form a serine/aspartate racemase family cluster based on phylogenetic analysis.	Aspartic Acid	86-95	aspartyl-tRNA synthetase 2 (mitochondrial)	Mus musculus	16-21
28359674-2	2017	A focused library of 6,8-dioxa-3-azabicyclo[3.2.1]-octane peptidomimetic scaffolds was synthesized and assayed towards BACE1 enzyme, resulting in the identification of a thiolactam-containing hit compound possessing IC50 in the low micromolar range, and confirming the bicyclic acetal portion as a potential transition state analogue in the interaction with catalytic aspartic acid residues.	Aspartic Acid	368-381	beta-secretase 1	Homo sapiens	119-124
28922740-5	2017	Analysis of the PglB crystal structures from Campylobacter lari and the soluble C-terminal domain from C. jejuni suggests a particularly important structural role for the aspartate residue and the two following glycine residues, as well as a more subtle, less defined role for the lysine residue.	Aspartic Acid	171-180	epiphycan	Homo sapiens	16-20
28801461-10	2017	Third, an Arg-Asp dipeptide immediately preceding the ZF helix, conserved in two PRDM9a fingers and three PRDM9c fingers, permits adaptability to variations from a C:G base pair (G-Arg interaction) to a G:C base pair (C-Asp interaction).	Aspartic Acid	14-17	PR/SET domain 9	Homo sapiens	81-86
28643418-6	2017	As we hypothesized, use of negatively charged amino acids such as aspartate and glutamate in protein loops increased the interactions of BMP2-Ca2+ and resulted in its slower and more sustained released from CaP scaffolds compare to commercial RHBMP2.	Aspartic Acid	66-75	bone morphogenetic protein 2	Homo sapiens	137-141
28771917-14	2017	Two regions (Asp-7 to Thr-15 and Ala-32 to Thr-38) therefore appeared important for the binding of 5B9 and KKO on PF4 modified by heparin.	Aspartic Acid	13-16	platelet factor 4	Homo sapiens	114-117
28731187-5	2017	The amino acid sequence of SHP was identified as Leu-Lys-Glu-Glu-Asn-Arg-Arg-Arg-Arg-Asp with a molecular mass of 1371.53 Da.	Aspartic Acid	85-88	nuclear receptor subfamily 0 group B member 2	Homo sapiens	27-30
28653316-7	2017	Altogether, we found that AFP interacts with caspase-3 through precise amino acids, namely loop-4 residues Glu-248, Asp-253 and His-257.	Aspartic Acid	116-119	alpha fetoprotein	Homo sapiens	26-29
28653316-7	2017	Altogether, we found that AFP interacts with caspase-3 through precise amino acids, namely loop-4 residues Glu-248, Asp-253 and His-257.	Aspartic Acid	116-119	caspase 3	Homo sapiens	45-54
28551094-4	2017	METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr705, and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin.	Aspartic Acid	155-158	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
28551094-4	2017	METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr705, and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin.	Aspartic Acid	155-158	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	108-113
28760343-1	2017	RACK1 is a seven Trp-Asp 40 repeat protein, which interacts with a wide range of kinases and proteins.	Aspartic Acid	21-24	receptor for activated C kinase 1	Homo sapiens	0-5
28432839-3	2017	Unlike Kex2, however, ASP lacks an intramolecular chaperone N-terminal propeptide, instead utilizes the external chaperone ORF2 for proper folding, therefore, ASP and its homologues constitute a new subfamily in the subtilisin family.	Aspartic Acid	159-162	kexin KEX2	Saccharomyces cerevisiae S288C	7-11
28916765-3	2017	This step requires protonation by a conserved aspartate of the pyridine nitrogen of PLP to enhance its ability to stabilize the carbanionic intermediate.	Aspartic Acid	46-55	pyridoxal phosphatase	Homo sapiens	84-87
29254168-0	2017	LC-MS-based metabolomics revealed SLC25A22 as an essential regulator of aspartate-derived amino acids and polyamines in KRAS-mutant colorectal cancer.	Aspartic Acid	72-81	solute carrier family 25 member 22	Homo sapiens	34-42
29254168-0	2017	LC-MS-based metabolomics revealed SLC25A22 as an essential regulator of aspartate-derived amino acids and polyamines in KRAS-mutant colorectal cancer.	Aspartic Acid	72-81	KRAS proto-oncogene, GTPase	Homo sapiens	120-124
29254168-5	2017	Targeted metabolomics including 24 metabolites revealed that most tricarboxylic acid (TCA) cycle intermediates, aspartate-derived asparagine, alanine and ornithine-derived polyamines were strongly down-regulated in SLC25A22 knockdown cells.	Aspartic Acid	112-121	solute carrier family 25 member 22	Homo sapiens	215-223
29254168-8	2017	Collectively, SLC25A22 acts as an essential metabolic regulator during CRC progression as it promotes the synthesis of aspartate-derived amino acids and polyamines in KRAS mutant CRC cells.	Aspartic Acid	119-128	solute carrier family 25 member 22	Homo sapiens	14-22
29254168-8	2017	Collectively, SLC25A22 acts as an essential metabolic regulator during CRC progression as it promotes the synthesis of aspartate-derived amino acids and polyamines in KRAS mutant CRC cells.	Aspartic Acid	119-128	KRAS proto-oncogene, GTPase	Homo sapiens	167-171
29312551-11	2017	Moreover, Phospho-mimetic aspartate substitution mutant T172D of Rab37 significantly promotes tumor metastasis in vivo.	Aspartic Acid	26-35	RAB37, member RAS oncogene family	Homo sapiens	65-70
28916765-6	2017	This result, together with two crystal structures of the conserved aspartate pathogenic variant (D183N) and the molecular modeling of the transaldimination step, led us to propose that an interplay of opposite forces, which we named spring mechanism, finely tunes PLP geometry during catalysis and is essential to move the external aldimine in the correct position in order for the 1,3-proton transfer to occur.	Aspartic Acid	67-76	pyridoxal phosphatase	Homo sapiens	264-267
28729424-6	2017	Scanning mutagenesis of putative residues responsible for pH-dependent transport via hENT3 revealed that the ionization states of Asp-219 and Glu-447, and not His, strongly determined the pH-dependent transport permissible-impermissible states of the transporter.	Aspartic Acid	130-133	solute carrier family 29 member 3	Homo sapiens	85-90
28729424-9	2017	Our results suggest a putative pH-sensing role for Asp-219 and Glu-447 in hENT3 and that the size, ionization state, or electronegative polarity at these positions is crucial for obligate acidic pH-dependent activity.	Aspartic Acid	51-54	solute carrier family 29 member 3	Homo sapiens	74-79
28874751-7	2017	The glutamate is conserved between PS and PC flippases, whereas the arginine is replaced by a negatively charged aspartate in ATP8B1.	Aspartic Acid	113-122	ATPase phospholipid transporting 8B1	Homo sapiens	126-132
28877491-10	2017	These results demonstrate that only the amphiphile that thinned Ld lipid domains increased beta1-integrin-Arg-Gly-Asp-peptide affinity and valency, thus implicating Ld domains in modulation of integrin adhesion, nascent adhesion formation, and cell migration.	Aspartic Acid	114-117	integrin subunit beta 1	Homo sapiens	91-105
28627122-6	2017	The alanine scanning and shuffling the amino acid residues of BP4 (Tyr-Lys-Asp-Gly) demonstrated that the Tyr-Lys-Asp-Gly consensus sequence is important for the inhibitory effect of the peptide on hypothermia.	Aspartic Acid	75-78	Blood pressure QTL 4	Rattus norvegicus	62-65
28726636-6	2017	Here, we demonstrate that these fusion proteins are cleaved by caspases-1 and -11 at Asp-276.	Aspartic Acid	85-88	caspase 1	Homo sapiens	63-81
28710924-3	2017	There are two catalytic aspartates (ASP32 and ASP228) presents in the active domain of BACE1.	Aspartic Acid	24-34	beta-secretase 1	Homo sapiens	87-92
28932620-1	2017	The cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid [Baker E. N.J. Mol.	Aspartic Acid	141-154	cathepsin B	Homo sapiens	4-21
28835770-9	2017	Functionally, QXHC candidate targets were significantly associated with several biological pathways, such as VEGF and Chemokine signaling pathways, Alanine/aspartate/glutamate metabolism, Long-term depression and T/B cell receptor signaling pathway.	Aspartic Acid	156-165	vascular endothelial growth factor A	Homo sapiens	109-113
28627122-11	2017	These results suggest that biotinylated peptides, especially BP21, can specifically and markedly inhibit anaphylactic reactions in vivo and that this involves direct interaction of its Tyr-Lys-Asp-Gly region with PAF.	Aspartic Acid	193-196	Blood pressure QTL 21	Rattus norvegicus	61-65
28627122-11	2017	These results suggest that biotinylated peptides, especially BP21, can specifically and markedly inhibit anaphylactic reactions in vivo and that this involves direct interaction of its Tyr-Lys-Asp-Gly region with PAF.	Aspartic Acid	193-196	PCNA clamp associated factor	Rattus norvegicus	213-216
28850328-4	2017	Oligomerization is triggered when polyphosphates bind to the polylysine patch in C2B domain and is stabilized by Mg2+, which neutralizes the Ca2+-binding aspartic acids that likely contribute to the C2B interface in the oligomer.	Aspartic Acid	154-168	secretoglobin family 2B member 3, pseudogene	Homo sapiens	81-84
28850328-4	2017	Oligomerization is triggered when polyphosphates bind to the polylysine patch in C2B domain and is stabilized by Mg2+, which neutralizes the Ca2+-binding aspartic acids that likely contribute to the C2B interface in the oligomer.	Aspartic Acid	154-168	secretoglobin family 2B member 3, pseudogene	Homo sapiens	199-202
28620826-9	2017	Many amino acids and citric acid cycle intermediates and their ester forms were individually supplemented to the cells with L-serine, L-proline, L-aspartate, or L-glutamine decreasing ROS production in oxidatively stressed alpha-synuclein overexpressing cells, while diethyl oxaloacetate or L-valine supplementation increased ATP levels.	Aspartic Acid	145-156	synuclein alpha	Homo sapiens	223-238
29291213-8	2017	The results revealed that the common pharmacophore hypothesis ADHPR.1 was used for 3D-QSAR model development and the most active compound, CXCR4 antagonist no.44 which is a imidazopyridine-tetrahydro-8-quinolinamine derivative interacted with the CXCR4 receptor residue ASP 97 by the formation of a hydrogen bond.	Aspartic Acid	270-273	C-X-C motif chemokine receptor 4	Homo sapiens	139-144
29291213-8	2017	The results revealed that the common pharmacophore hypothesis ADHPR.1 was used for 3D-QSAR model development and the most active compound, CXCR4 antagonist no.44 which is a imidazopyridine-tetrahydro-8-quinolinamine derivative interacted with the CXCR4 receptor residue ASP 97 by the formation of a hydrogen bond.	Aspartic Acid	270-273	C-X-C motif chemokine receptor 4	Homo sapiens	247-252
28701415-5	2017	The complex structure reveals that, unlike a linear and elongated conformation in the phosphor-peptide/GK complexes, the MAP1A peptide adopts a unique conformation with a stretch of hydrophobic residues far from each other in the primary sequence clustering and interacting with the "hydrophobic site" of PSD-95 GK and a highly conserved aspartic acid of MAP1A (D2117) mimicking the phosphor-serine/threonine in binding to the "phosphor-site" of PSD-95 GK.	Aspartic Acid	338-351	microtubule associated protein 1A	Homo sapiens	121-126
28817652-7	2017	Leptin was furthermore strongly associated with alanine and aspartate (Bonferroni corrected P[PBF] = 5.7x10-8 and 1.7x10-6, respectively), and negatively associated to the sum of the non-esterified fatty acids (NEFA) and the sum of the long-chain acylcarnitines C12-C18 (PBF = 0.009 and 0.0001, respectively).	Aspartic Acid	60-69	leptin	Homo sapiens	0-6
28659375-6	2017	While ECs can take up asparagine, silencing asparagine synthetase (ASNS, which converts glutamine-derived nitrogen and aspartate to asparagine) impaired EC sprouting even in the presence of glutamine and asparagine.	Aspartic Acid	119-128	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	44-65
28659375-6	2017	While ECs can take up asparagine, silencing asparagine synthetase (ASNS, which converts glutamine-derived nitrogen and aspartate to asparagine) impaired EC sprouting even in the presence of glutamine and asparagine.	Aspartic Acid	119-128	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	67-71
28470883-3	2017	Diverse, fragment-sized 4-halopyridines inactivated human dimethylarginine dimethylaminohydrolase-1 (DDAH1) through covalent modification of the active site cysteine, acting as quiescent affinity labels that required off-pathway catalysis through stabilization of the protonated pyridinium by a neighboring aspartate residue.	Aspartic Acid	307-316	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	58-99
29137311-3	2017	Notably, crenolanib inhibits constitutively active mutant-FLT3 isoforms resulting from amino acid substitutions of aspartic acid at codon 835, which is homologous to codon 816 in the KIT gene - suggesting sensitivity against mutant-KIT D816 isoforms as well.	Aspartic Acid	115-128	fms related receptor tyrosine kinase 3	Homo sapiens	58-62
28470883-3	2017	Diverse, fragment-sized 4-halopyridines inactivated human dimethylarginine dimethylaminohydrolase-1 (DDAH1) through covalent modification of the active site cysteine, acting as quiescent affinity labels that required off-pathway catalysis through stabilization of the protonated pyridinium by a neighboring aspartate residue.	Aspartic Acid	307-316	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	101-106
28642370-4	2017	In vitro experiments with purified recombinant CYP46A1 indicated that CYP46A1 is activated by l-glutamate (l-Glu), l-aspartate, gamma-aminobutyric acid, and acetylcholine, with l-Glu eliciting the highest increase (3-fold) in CYP46A1-mediated cholesterol 24-hydroxylation.	Aspartic Acid	115-126	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	47-54
28642370-4	2017	In vitro experiments with purified recombinant CYP46A1 indicated that CYP46A1 is activated by l-glutamate (l-Glu), l-aspartate, gamma-aminobutyric acid, and acetylcholine, with l-Glu eliciting the highest increase (3-fold) in CYP46A1-mediated cholesterol 24-hydroxylation.	Aspartic Acid	115-126	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	70-77
28300425-4	2017	HNRNPD was found carrying two novel heterozygous mutations - a stop gain mutation that truncated the protein at 249th and 268th amino acid position and a single base missense mutation replacing Aspartate with Valine at 300th amino acid.	Aspartic Acid	194-203	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	0-6
28642370-4	2017	In vitro experiments with purified recombinant CYP46A1 indicated that CYP46A1 is activated by l-glutamate (l-Glu), l-aspartate, gamma-aminobutyric acid, and acetylcholine, with l-Glu eliciting the highest increase (3-fold) in CYP46A1-mediated cholesterol 24-hydroxylation.	Aspartic Acid	115-126	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	70-77
28824188-5	2017	A novel mutation (173 A&gt;G) in exon 4 with a predicted amino acid change of 58 Asp&gt;Gly was also found in a Kinh newborn girl and her father, and it was designated as G6PD Ho Chi Minh.	Aspartic Acid	81-84	kinesin family member 5B	Homo sapiens	112-116
28824188-5	2017	A novel mutation (173 A&gt;G) in exon 4 with a predicted amino acid change of 58 Asp&gt;Gly was also found in a Kinh newborn girl and her father, and it was designated as G6PD Ho Chi Minh.	Aspartic Acid	81-84	glucose-6-phosphate dehydrogenase	Homo sapiens	171-175
28580535-1	2017	About 20 years ago an American study suggested that daily subcutaneous injections of a metabolically inactive insulin analogue with a single amino acid substitution (aspartic acid instead of phenylalanine) at position 25 of the B chain was as effective as intact insulin in preventing autoimmune diabetes in NOD mice.	Aspartic Acid	166-179	insulin	Homo sapiens	110-117
28540523-5	2017	In contrast to zinc, which binds to the phosphocysteine intermediate in the closed conformation of protein tyrosine phosphatase 1B when the catalytic aspartate has moved into the active site, other divalent cations such as cadmium and copper may also bind to the enzyme in the open conformation.	Aspartic Acid	150-159	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	99-130
28792792-6	2017	In this regard, the sequences of six new synthetic IL-24s that have been modified by RGD (Arg-Gly-Asp) or NGR (CRNGRGPDC) were aligned and their structures were modeled through homology modeling to evaluate their attachment potential to cognate receptor complexes such as IL-20R1/IL-20R2, IL-22R1/IL-20R2, or Sig1R.	Aspartic Acid	98-101	interleukin 24	Homo sapiens	51-56
28658579-6	2017	These findings highlight the importance of the conformational plasticity and accessibility of the arginine-glycine-aspartic acid (RGD) binding site in FN, which, in turn, mediates cell signaling in physiological and synthetic environments.	Aspartic Acid	115-128	fibronectin 1	Homo sapiens	151-153
28766112-5	2017	The molecular simulations revealed that oleanolic acid and ursolic acid interact with amino acid residues within the binding pocket of human salivary alpha-amylase, among which the side chain of Arg195 and Asp 197 was supposed to be important in imparting the inhibitory activity of triterpenoids.	Aspartic Acid	206-209	amylase alpha 1A	Homo sapiens	141-163
28552745-7	2017	The CSE inhibitor dl-propargylglycine (PPG) and aspartate (limits MPST) had no effect alone, but when applied together with AOAA the hypoxic relaxation response was further reduced.	Aspartic Acid	48-57	mercaptopyruvate sulfurtransferase	Homo sapiens	66-70
28665127-2	2017	This compound was synthesized from l-aspartic acid, and its activities were confirmed by three classical cytokinin bioassays as well as by using binding and activation assays with the Arabidopsis cytokinin receptors AHK3 and CRE1/AHK4.	Aspartic Acid	35-50	histidine kinase 3	Arabidopsis thaliana	216-220
28665127-2	2017	This compound was synthesized from l-aspartic acid, and its activities were confirmed by three classical cytokinin bioassays as well as by using binding and activation assays with the Arabidopsis cytokinin receptors AHK3 and CRE1/AHK4.	Aspartic Acid	35-50	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	225-229
28665127-2	2017	This compound was synthesized from l-aspartic acid, and its activities were confirmed by three classical cytokinin bioassays as well as by using binding and activation assays with the Arabidopsis cytokinin receptors AHK3 and CRE1/AHK4.	Aspartic Acid	35-50	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	230-234
28750687-1	2017	BACKGROUND: Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate.	Aspartic Acid	117-126	argininosuccinate synthase 1	Homo sapiens	12-38
28750687-1	2017	BACKGROUND: Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate.	Aspartic Acid	117-126	argininosuccinate synthase 1	Homo sapiens	40-45
28559428-0	2017	Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1.	Aspartic Acid	45-54	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	109-113
28562331-7	2017	On GLI1, substitution of AMPK phosphorylation sites to aspartic acid (GLI13E) results in stronger binding affinity of GLI1 with beta-TrCP, accompanied by enhanced GLI1 ubiquitination and later degradation.	Aspartic Acid	55-68	GLI family zinc finger 1	Homo sapiens	3-7
28562331-7	2017	On GLI1, substitution of AMPK phosphorylation sites to aspartic acid (GLI13E) results in stronger binding affinity of GLI1 with beta-TrCP, accompanied by enhanced GLI1 ubiquitination and later degradation.	Aspartic Acid	55-68	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	25-29
28562331-7	2017	On GLI1, substitution of AMPK phosphorylation sites to aspartic acid (GLI13E) results in stronger binding affinity of GLI1 with beta-TrCP, accompanied by enhanced GLI1 ubiquitination and later degradation.	Aspartic Acid	55-68	GLI family zinc finger 1	Homo sapiens	70-74
28562331-7	2017	On GLI1, substitution of AMPK phosphorylation sites to aspartic acid (GLI13E) results in stronger binding affinity of GLI1 with beta-TrCP, accompanied by enhanced GLI1 ubiquitination and later degradation.	Aspartic Acid	55-68	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	128-137
28562331-7	2017	On GLI1, substitution of AMPK phosphorylation sites to aspartic acid (GLI13E) results in stronger binding affinity of GLI1 with beta-TrCP, accompanied by enhanced GLI1 ubiquitination and later degradation.	Aspartic Acid	55-68	GLI family zinc finger 1	Homo sapiens	70-74
28981783-4	2017	The content of a conjugated form of the plant growth hormone auxin, indole-3-acetic acid (IAA)-Asp, was higher in wri1-1 plants compared with the wild-type.	Aspartic Acid	95-98	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	114-118
28733581-8	2017	Mutations of charged residues in the aspartic acid-arginine-tyrosine motif of the M2 muscarinic receptor, but not intracellular loop 3, significantly impaired the voltage-dependence of RGS4 function.	Aspartic Acid	37-50	regulator of G-protein signaling 4 S homeolog	Xenopus laevis	185-189
28429368-1	2017	ARALAR/AGC1 (aspartate-glutamate mitochondrial carrier 1) is an important component of the NADH malate-aspartate shuttle (MAS).	Aspartic Acid	13-22	solute carrier family 25 member 12	Homo sapiens	0-6
28659495-5	2017	Treatment of cells with staurosporine or the death receptor ligand FasL triggers caspase-mediated cleavage of SMSr at a conserved aspartate located downstream of the enzyme"s SAM domain and upstream of its first membrane span.	Aspartic Acid	130-139	Fas ligand	Homo sapiens	67-71
28659495-5	2017	Treatment of cells with staurosporine or the death receptor ligand FasL triggers caspase-mediated cleavage of SMSr at a conserved aspartate located downstream of the enzyme"s SAM domain and upstream of its first membrane span.	Aspartic Acid	130-139	sterile alpha motif domain containing 8	Homo sapiens	110-114
28652325-2	2017	FcepsilonR1gamma and CD247 share high sequence homology and form disulphide-linked homodimers that contain a pair of acidic aspartic acid residues in their transmembrane (TM) domains that mediate assembly, via interaction with an arginine residue at a similar register to these aspartic acids, with the activating immunoreceptors.	Aspartic Acid	124-137	CD247 molecule	Homo sapiens	0-26
28652325-2	2017	FcepsilonR1gamma and CD247 share high sequence homology and form disulphide-linked homodimers that contain a pair of acidic aspartic acid residues in their transmembrane (TM) domains that mediate assembly, via interaction with an arginine residue at a similar register to these aspartic acids, with the activating immunoreceptors.	Aspartic Acid	278-292	CD247 molecule	Homo sapiens	0-26
28652336-9	2017	Structural analysis of nSMase2 and the extended N-SMase family shows that the DK switch can adopt different conformations to reposition a universally conserved Asp (D) residue involved in catalysis.	Aspartic Acid	160-163	sphingomyelin phosphodiesterase 3	Homo sapiens	23-30
28652336-10	2017	Mutation of this Asp residue in nSMase2 disrupts catalysis, allosteric activation, stimulation by phosphatidylserine, and pharmacological inhibition by the lipid-competitive inhibitor GW4869.	Aspartic Acid	17-20	sphingomyelin phosphodiesterase 3	Homo sapiens	32-39
28429368-1	2017	ARALAR/AGC1 (aspartate-glutamate mitochondrial carrier 1) is an important component of the NADH malate-aspartate shuttle (MAS).	Aspartic Acid	13-22	aggrecan	Mus musculus	7-11
28600229-1	2017	Recently, linkage analysis of two large unrelated multigenerational families identified a novel dilated cardiomyopathy (DCM)-linked mutation in the gene coding for alpha-tropomyosin (TPM1) resulting in the substitution of an aspartic acid for an asparagine (at residue 230).	Aspartic Acid	225-238	tropomyosin 1	Homo sapiens	164-181
28429368-1	2017	ARALAR/AGC1 (aspartate-glutamate mitochondrial carrier 1) is an important component of the NADH malate-aspartate shuttle (MAS).	Aspartic Acid	13-22	mitochondrial carrier 1	Mus musculus	33-56
28658312-10	2017	beta-1,3-glucanase protein structural model revealed that active sites Glutamate 628 and Aspartate 569 of the catalytic domain acted as proton donor and nucleophile having role in cleaving beta-1,3-glycosidic bonds and pathogen hyphal lysis.	Aspartic Acid	89-98	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	0-8
28658312-10	2017	beta-1,3-glucanase protein structural model revealed that active sites Glutamate 628 and Aspartate 569 of the catalytic domain acted as proton donor and nucleophile having role in cleaving beta-1,3-glycosidic bonds and pathogen hyphal lysis.	Aspartic Acid	89-98	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	189-197
28516893-11	2017	Since PEG is a synthetic polymer devoid of cell attachment sites, we could overcome this limitation by tethering Arg-Gly-Asp-Ser (RGDS) peptide to the PEG hydrogel microspheres; upon RGDS tethering, we observed uniform cell dispersion.	Aspartic Acid	121-124	ral guanine nucleotide dissociation stimulator	Mus musculus	130-134
29299118-1	2017	L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid, and its depletion induces leukemic cell death.	Aspartic Acid	85-100	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
29299118-1	2017	L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid, and its depletion induces leukemic cell death.	Aspartic Acid	85-100	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-5
28606087-1	2017	BACKGROUND: Aspartate, which is converted from oxaloacetate (OAA) by aspartate aminotransferase, is considered an important precursor for purine salvage and pyrimidine de novo biosynthesis, and is thus indispensable for the growth of Plasmodium parasites at the asexual blood stages.	Aspartic Acid	12-21	PBANKA_030230	Plasmodium berghei ANKA	69-95
28370344-7	2017	The acidic and basic components of the BACE1 catalytic dyad are clear, while either aspartic acid of the CatD catalytic dyad could play the role of acid or base.	Aspartic Acid	84-97	beta-secretase 1	Homo sapiens	39-44
28370344-7	2017	The acidic and basic components of the BACE1 catalytic dyad are clear, while either aspartic acid of the CatD catalytic dyad could play the role of acid or base.	Aspartic Acid	84-97	cathepsin D	Homo sapiens	105-109
28235644-0	2017	Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells.	Aspartic Acid	37-46	solute carrier family 25 member 12	Homo sapiens	75-79
28235644-1	2017	The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1) catalyzes a Ca2+-stimulated export of aspartate to the cytosol in exchange for glutamate, and is a key component of the malate-aspartate shuttle which transfers NADH reducing equivalents from the cytosol to mitochondria.	Aspartic Acid	18-27	solute carrier family 25 member 12	Homo sapiens	57-61
28235644-1	2017	The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1) catalyzes a Ca2+-stimulated export of aspartate to the cytosol in exchange for glutamate, and is a key component of the malate-aspartate shuttle which transfers NADH reducing equivalents from the cytosol to mitochondria.	Aspartic Acid	101-110	solute carrier family 25 member 12	Homo sapiens	57-61
28235644-1	2017	The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1) catalyzes a Ca2+-stimulated export of aspartate to the cytosol in exchange for glutamate, and is a key component of the malate-aspartate shuttle which transfers NADH reducing equivalents from the cytosol to mitochondria.	Aspartic Acid	101-110	solute carrier family 25 member 12	Homo sapiens	57-61
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Aspartic Acid	89-98	caspase 3	Mus musculus	34-43
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Aspartic Acid	89-98	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	66-71
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Aspartic Acid	89-98	caspase 3	Mus musculus	150-159
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Aspartic Acid	89-98	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	172-177
28342750-4	2017	Here, we report that mutating the caspase-3 consensus site in the EAAT2 sequence with an aspartate to asparagine mutation (D504N), thereby inhibiting caspase-3 cleavage of EAAT2, confers protection to the SOD1-G93A mouse.	Aspartic Acid	89-98	superoxide dismutase 1, soluble	Mus musculus	205-209
27885727-0	2017	Growth inhibitory and proapoptotic effects of l-asparaginase from Fusarium culmorum ASP-87 on human leukemia cells (Jurkat).	Aspartic Acid	84-87	asparaginase and isoaspartyl peptidase 1	Homo sapiens	46-60
27885727-7	2017	l-asparaginase purified from F. culmorum ASP-87 showed significant and selective cytotoxic and apoptotic effects on human T-cell leukemic cells in dose-dependent manner.	Aspartic Acid	41-44	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
28457719-5	2017	Comparison of mature G172D and wildtype GA models reveals that the presence of Asp 172 near the catalytic site affects substrate catabolism in mature G172D, making it less efficient in substrate processing.	Aspartic Acid	79-82	aspartylglucosaminidase	Homo sapiens	40-42
28518188-3	2017	Applied to the case of the photochromic Anabaena sensory rhodopsin protein, the model succeeds in reproducing qualitatively the reported experimental data, confirming the importance of aspartic acid 217 in the observed blue shift in the lambdamax of ASR at neutral pH.	Aspartic Acid	185-198	rhodopsin	Homo sapiens	57-66
28595570-9	2017	3D homology modeling of AtPAE8 from clade 2 with a human Notum protein showed an alpha/beta hydrolase structure with the hallmark Ser-His-Asp of the active site.	Aspartic Acid	138-141	Pectinacetylesterase family protein	Arabidopsis thaliana	24-30
28595570-9	2017	3D homology modeling of AtPAE8 from clade 2 with a human Notum protein showed an alpha/beta hydrolase structure with the hallmark Ser-His-Asp of the active site.	Aspartic Acid	138-141	notum, palmitoleoyl-protein carboxylesterase	Homo sapiens	57-62
28335001-5	2017	Furthermore, structural modeling predicts that each RAP domain of FASTK proteins contains a nuclease fold with a conserved aspartate residue at the putative active site.	Aspartic Acid	123-132	Fas activated serine/threonine kinase	Homo sapiens	66-71
26907088-0	2017	Aspartate attenuates intestinal injury and inhibits TLR4 and NODs/NF-kappaB and p38 signaling in weaned pigs after LPS challenge.	Aspartic Acid	0-9	toll like receptor 4	Sus scrofa	52-56
26907088-7	2017	In addition, Asp decreased plasma, jejunal and ileal tumor necrosis factor-alpha concentration and ileal caspase-3 protein expression linearly and quadratically.	Aspartic Acid	13-16	tumor necrosis factor	Sus scrofa	53-80
26907088-7	2017	In addition, Asp decreased plasma, jejunal and ileal tumor necrosis factor-alpha concentration and ileal caspase-3 protein expression linearly and quadratically.	Aspartic Acid	13-16	caspase 3	Sus scrofa	105-114
26907088-10	2017	CONCLUSIONS: These results indicate that Asp supplementation is associated with inhibition of TLR4 and NODs/NF-kappaB and p38 signaling pathways and concomitant improvement of intestinal integrity under an inflammatory condition.	Aspartic Acid	41-44	toll like receptor 4	Sus scrofa	94-98
28587322-6	2017	DNA sequencing revealed a novel c.1270 A&gt;G mutation in exon 6 of the FGD1 gene, which led to an amino acid conversion of asparagine to aspartic acid on codon 424 and in silico analysis indicated that this novel missense mutation was pathogenic.	Aspartic Acid	138-151	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	72-76
28538181-3	2017	To investigate the mechanism mediating the effect of fumarase-related metabolites on hypertension, we considered the pathway in which L-malate can be converted to oxaloacetate, aspartate, argininosuccinate, and L-arginine, the substrate of nitric oxide (NO) synthase.	Aspartic Acid	177-186	fumarate hydratase	Rattus norvegicus	53-61
28538181-5	2017	Knockdown of fumarase in human kidney cells and vascular endothelial cells resulted in decreased levels of malate, aspartate, L-arginine, and NO.	Aspartic Acid	115-124	fumarate hydratase	Homo sapiens	13-21
28531096-0	2017	The Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation.	Aspartic Acid	8-11	crystallin gamma F, pseudogene	Homo sapiens	51-54
28516893-11	2017	Since PEG is a synthetic polymer devoid of cell attachment sites, we could overcome this limitation by tethering Arg-Gly-Asp-Ser (RGDS) peptide to the PEG hydrogel microspheres; upon RGDS tethering, we observed uniform cell dispersion.	Aspartic Acid	121-124	ral guanine nucleotide dissociation stimulator	Mus musculus	183-187
28341448-6	2017	Spg is therefore predicted to play an important role in the ASP.	Aspartic Acid	60-63	sponge	Drosophila melanogaster	0-3
28341448-7	2017	The specific knockdown of Spg by the breathless-GAL4 driver in tracheal cells induced lethality accompanied with a defect in ASP development and the induction of apoptosis.	Aspartic Acid	125-128	sponge	Drosophila melanogaster	26-29
28341448-9	2017	Furthermore, the overexpression of D-raf suppressed defects in survival and the proliferation of cells in the ASP induced by the knockdown of Spg.	Aspartic Acid	110-113	Raf oncogene	Drosophila melanogaster	35-40
28341448-9	2017	Furthermore, the overexpression of D-raf suppressed defects in survival and the proliferation of cells in the ASP induced by the knockdown of Spg.	Aspartic Acid	110-113	sponge	Drosophila melanogaster	142-145
28341448-10	2017	Collectively, these results indicate that Spg plays a critical role in ASP development and tracheal cell viability that is mediated by the ERK signaling pathway.	Aspartic Acid	71-74	sponge	Drosophila melanogaster	42-45
28500754-5	2017	Here we concomitantly modify the tails of XRCC4 and XLF by substituting fourteen previously identified phosphorylation sites with either alanine or aspartate residues.	Aspartic Acid	148-157	X-ray repair cross complementing 4	Homo sapiens	42-47
28500754-5	2017	Here we concomitantly modify the tails of XRCC4 and XLF by substituting fourteen previously identified phosphorylation sites with either alanine or aspartate residues.	Aspartic Acid	148-157	non-homologous end joining factor 1	Homo sapiens	52-55
29871349-2	2017	The SLC26A4 mutations were analyzed by direct sequencing.Result:A novel missense mutation(347G&gt;A) of SLC26A4 gene was found in a male patient,which led to a substitution of codon 116 from glycine to asparagic acid.	Aspartic Acid	202-216	solute carrier family 26 member 4	Homo sapiens	4-11
29871349-2	2017	The SLC26A4 mutations were analyzed by direct sequencing.Result:A novel missense mutation(347G&gt;A) of SLC26A4 gene was found in a male patient,which led to a substitution of codon 116 from glycine to asparagic acid.	Aspartic Acid	202-216	solute carrier family 26 member 4	Homo sapiens	104-111
28301223-0	2017	Antitumor Effect of Nanoparticle 131I-Labeled Arginine-Glycine-Aspartate-Bovine Serum Albumin-Polycaprolactone in Lung Cancer.	Aspartic Acid	63-72	albumin	Mus musculus	80-93
28409923-2	2017	In addition, acidic residues in the entrance channel, in particular an Asp and a Glu ~7 and ~15 A, respectively, from the heme, significantly enhance catalase activity.	Aspartic Acid	71-74	catalase	Homo sapiens	150-158
28299478-11	2017	Factor-2 explained 25.8% of the total variance and had maximum loadings on alanine, aspartic acid, serine and tyrosine.	Aspartic Acid	84-97	transcription termination factor 2	Homo sapiens	0-8
28346230-4	2017	Here we have shown that VHL-/- RCC cells rely on RC-derived aspartate to maintain de novo pyrimidine biosynthesis.	Aspartic Acid	60-69	von Hippel-Lindau tumor suppressor	Homo sapiens	24-27
28346230-5	2017	Glutaminase 1 (GLS1) inhibitors depleted pyrimidines and increased ROS in VHL-/- cells but not in VHL+/+ cells, which utilized glucose oxidation for glutamate and aspartate production.	Aspartic Acid	163-172	glutaminase	Homo sapiens	0-13
28346230-5	2017	Glutaminase 1 (GLS1) inhibitors depleted pyrimidines and increased ROS in VHL-/- cells but not in VHL+/+ cells, which utilized glucose oxidation for glutamate and aspartate production.	Aspartic Acid	163-172	glutaminase	Homo sapiens	15-19
28004516-1	2017	Peptides with an exposed arginine-glycine-aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin alphaV beta3 play an important role in targeted anticancer drug delivery.	Aspartic Acid	42-51	integrin subunit alpha V	Homo sapiens	94-115
28004516-1	2017	Peptides with an exposed arginine-glycine-aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin alphaV beta3 play an important role in targeted anticancer drug delivery.	Aspartic Acid	61-64	integrin subunit alpha V	Homo sapiens	94-115
28004516-4	2017	The specific identification sites included the guanidine group of the ARG residue in the RGD peptide and the carboxyl group of the ASP residue in integrin alphaV beta3 .	Aspartic Acid	131-134	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	162-167
28447612-6	2017	In addition, the MT-associated protein Mud/NuMA that is asymmetrically localized in an Asp-dependent manner at the nuclear envelope hemisphere where MT nucleation is higher promotes a separate route.	Aspartic Acid	87-90	mushroom body defect	Drosophila melanogaster	39-42
28368584-4	2017	The importance of the residue at position 11 for NTS1/NTS2 selectivity was further demonstrated by the design of new NT analogues bearing basic (Lys, Orn) or acid (Asp or Glu) function.	Aspartic Acid	164-167	neurotensin	Homo sapiens	49-53
28447612-6	2017	In addition, the MT-associated protein Mud/NuMA that is asymmetrically localized in an Asp-dependent manner at the nuclear envelope hemisphere where MT nucleation is higher promotes a separate route.	Aspartic Acid	87-90	mushroom body defect	Drosophila melanogaster	43-47
28396387-6	2017	We found that this increase in 2OG levels, either by OGDH suppression or exogenous 2OG treatment, resulted in aspartate depletion that was specifically manifested as auxotrophy within PIK3CA mutant cells.	Aspartic Acid	110-119	oxoglutarate dehydrogenase	Homo sapiens	53-57
28593130-0	2017	The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission.	Aspartic Acid	82-91	solute carrier family 38, member 10	Mus musculus	36-44
28593130-9	2017	In conclusion, the bidirectional transport of glutamine, glutamate, and aspartate by SLC38A10, and the immunostaining detected in neurons and astrocytes, suggest that SLC38A10 plays a role in pathways involved in neurotransmission.	Aspartic Acid	72-81	solute carrier family 38, member 10	Mus musculus	85-93
28593130-9	2017	In conclusion, the bidirectional transport of glutamine, glutamate, and aspartate by SLC38A10, and the immunostaining detected in neurons and astrocytes, suggest that SLC38A10 plays a role in pathways involved in neurotransmission.	Aspartic Acid	72-81	solute carrier family 38, member 10	Mus musculus	167-175
28198180-5	2017	CLPs containing 120 GFP molecules and those containing approximately 150 dye molecules were both shown to bind human integrin via a naturally occurring Arg-Gly-Asp motif found on an exposed loop of the VP7 trimeric spike.	Aspartic Acid	160-163	colipase	Homo sapiens	0-4
28198180-5	2017	CLPs containing 120 GFP molecules and those containing approximately 150 dye molecules were both shown to bind human integrin via a naturally occurring Arg-Gly-Asp motif found on an exposed loop of the VP7 trimeric spike.	Aspartic Acid	160-163	VP7	Bluetongue virus	202-205
28396387-6	2017	We found that this increase in 2OG levels, either by OGDH suppression or exogenous 2OG treatment, resulted in aspartate depletion that was specifically manifested as auxotrophy within PIK3CA mutant cells.	Aspartic Acid	110-119	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	184-190
28396387-8	2017	Consequently, because PIK3CA mutant cells exhibit a profound reliance on glucose metabolism, malate-aspartate shuttle deregulation leads to a specific proliferative block due to the inability to maintain NAD+/NADH homeostasis.	Aspartic Acid	100-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	22-28
28439078-8	2017	The present study is the first to report a significant association between SIRT1 polymorphisms and ASP in adolescents.	Aspartic Acid	99-102	sirtuin 1	Homo sapiens	75-80
29071955-8	2017	On day 15, the effect of the LR 3 + PC 6 group was significantly superior to that of the LR 3, PC 6, and LR 3 + non-acupoint groups in reducing the levels of SBP, DBP, and MBP (P&lt;0.05).Compared with the normal control group, the contents of Asp and Glu in RVLM were significantly higher in the model group (P&lt;0.05).	Aspartic Acid	244-247	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	36-40
29071955-10	2017	CONCLUSIONS: Acupuncture stimulation of PC 6, LR 3, LR 3 + non-acupoint and LR 3 + PC 6 (in particular) is effective in lowering blood pressure in spontaneous hypertension rats, which may be associated with its effects in lowering Asp and Glu contents in RVLM.	Aspartic Acid	231-234	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	40-44
29071955-10	2017	CONCLUSIONS: Acupuncture stimulation of PC 6, LR 3, LR 3 + non-acupoint and LR 3 + PC 6 (in particular) is effective in lowering blood pressure in spontaneous hypertension rats, which may be associated with its effects in lowering Asp and Glu contents in RVLM.	Aspartic Acid	231-234	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	83-87
28230985-4	2017	In parallel, high-throughput screening (HTS) was conducted using the fluorescent probe substrate ASP+ in cells overexpressing human OCT1.	Aspartic Acid	97-101	solute carrier family 22 member 1	Homo sapiens	132-136
28235798-6	2017	We identified a novel basic protein motif consisting of a cluster of three dibasic residues (356RR357, 359KK360, and 362KK363) in the membrane-proximal domain of the L-selectin tail as well as a doublet of aspartic acid residues (369DD370) in the membrane-distal end of the L-selectin tail involved in mu1A binding.	Aspartic Acid	206-219	selectin L	Homo sapiens	166-176
28414724-2	2017	In this study, sequence alignment revealed that the His-Asp-Ser catalytic triad is embedded in the TAAHC-DIAL-GDSGGP sequence motif, establishing Bm-SP142 as a serine protease.	Aspartic Acid	56-59	serine protease	Bombyx mori	160-175
28416846-2	2017	The Arg-Gly-Asp-Ser sequence (RGDS) was confirmed of affecting cell adhesion.	Aspartic Acid	12-15	ral guanine nucleotide dissociation stimulator	Homo sapiens	30-34
28194754-10	2017	A comparison of extracellular amino acids in TRPA1 identified three negatively charged amino acid residues (glutamate and aspartate) near the outer pore vestibule that are involved in heat-evoked TRPA1 activation in the presence of extracellular Ca2+ .	Aspartic Acid	122-131	transient receptor potential cation channel subfamily A member 1	Gallus gallus	45-50
28194754-10	2017	A comparison of extracellular amino acids in TRPA1 identified three negatively charged amino acid residues (glutamate and aspartate) near the outer pore vestibule that are involved in heat-evoked TRPA1 activation in the presence of extracellular Ca2+ .	Aspartic Acid	122-131	transient receptor potential cation channel subfamily A member 1	Gallus gallus	196-201
28512575-1	2017	Multiple possibilities for the coordination of fac-[Re(CO)3(H2O)3]+ to a protein have been determined and include binding to Asp, Glu, Arg and His amino-acid residues as well as to the C-terminal carboxylate in the vicinity of Leu and Pro.	Aspartic Acid	125-128	FA complementation group C	Homo sapiens	47-50
28314989-7	2017	GOT1 is responsible for the conversion of glutamine-derived aspartate into OAA, which subsequently can be converted into malate and pyruvate.	Aspartic Acid	60-69	glutamic-oxaloacetic transaminase 1	Homo sapiens	0-4
28232482-4	2017	This network, which involves residues Asp-222, His-143, Thr-139, His-189, and structural waters, is located at the edge of PLP opposite the reactive Schiff base.	Aspartic Acid	38-41	pyridoxal phosphatase	Homo sapiens	123-126
28345083-1	2017	This paper reports that the bulk polymerization of l-aspartic acid diethyl ester catalyzed by immobilized CAL-B at 80  C for 24 h gives primarily (~95%) alpha-linked poly(l-aspartate) in 70% yield with DPavg = 50 and regioselectivity (alpha/beta) = 94 : 6.	Aspartic Acid	171-182	calbindin 1	Homo sapiens	106-111
28234481-8	2017	For example, 128KMEIVDDDVPSLW140 in betaB3 crystallin contains three sequential aspartic acid residues and is isomerized heavily in the WI fractions, while it is not modified at all in the WS fractions.	Aspartic Acid	80-93	crystallin beta B3	Bos taurus	36-53
28245108-5	2017	Here, we have successfully determined the disulfide structure for murine Meteorin by LC-MS analysis of fragments generated by trypsin plus endoprotease-Asp-N. For proteolytic fragments linked by more than one disulfide bond, we used electron transfer dissociation (ETD) to partially dissociate disulfide bonds followed by high-energy collisional dissociation (HCD) to determine disulfide linkages.	Aspartic Acid	152-155	meteorin, glial cell differentiation regulator	Mus musculus	73-81
28177792-5	2017	Among the carbon sources metabolized by Aeromonas in vitro, some were found to be components of intestinal mucin, including aspartic acid, glutamic acid, l-serine, galactose, N-acetyl-glucosamine, and glucose, which were used by all strains tested.	Aspartic Acid	124-137	LOC100508689	Homo sapiens	107-112
28220383-4	2017	Herein, we report on the development of aspartic acid-incorporated poly(2-hydroxyethyl methacrylate-L-aspartic acid) [poly(HEMA-MAsp)] cryogel for the removal of DDE from aqueous solutions for the first time in the literature.	Aspartic Acid	40-53	MBL associated serine protease 1	Homo sapiens	128-132
28025687-1	2017	Escherichia coli glutamate/aspartate-proton symporter GltP is a member of the Dicarboxylate/Amino Acid:Cation Symporter family of secondary active transport proteins.	Aspartic Acid	27-36	glycolipid transfer protein	Homo sapiens	54-58
28188227-9	2017	The presence of Erap1 increased the frequency of C-terminal Lys and Arg, of Glu and Asp at intermediate residues, and of N-terminal Gly.	Aspartic Acid	84-87	endoplasmic reticulum aminopeptidase 1	Rattus norvegicus	16-21
28264735-6	2017	In contrast, we found that Oct4-specific antibodies could not recognize Oct4 protein when this residue was replaced by aspartic acid (Oct4-S106D).	Aspartic Acid	119-132	POU domain, class 5, transcription factor 1	Mus musculus	27-31
28413183-3	2017	Finally, we found a new nonsynonymous single nucleotide variant (nsSNV) in solute carrier 24 family member 2 (SLC24A2) gene resulting in the substitution of native glutamic acid (E) into aspartic acid (D) at position of 287 amino acid (E287D) in SLC24A2 protein, and confirmed this variant by Sanger gene sequencing.	Aspartic Acid	187-200	solute carrier family 24 member 2	Homo sapiens	75-108
28413183-3	2017	Finally, we found a new nonsynonymous single nucleotide variant (nsSNV) in solute carrier 24 family member 2 (SLC24A2) gene resulting in the substitution of native glutamic acid (E) into aspartic acid (D) at position of 287 amino acid (E287D) in SLC24A2 protein, and confirmed this variant by Sanger gene sequencing.	Aspartic Acid	187-200	solute carrier family 24 member 2	Homo sapiens	110-117
28413183-3	2017	Finally, we found a new nonsynonymous single nucleotide variant (nsSNV) in solute carrier 24 family member 2 (SLC24A2) gene resulting in the substitution of native glutamic acid (E) into aspartic acid (D) at position of 287 amino acid (E287D) in SLC24A2 protein, and confirmed this variant by Sanger gene sequencing.	Aspartic Acid	187-200	solute carrier family 24 member 2	Homo sapiens	246-253
28377545-8	2017	RESULTS: The exome variant analysis identified a novel missense mutation (c.3878C &gt; A) in WDR62 gene in exon 30 resulting in amino acid change from alanine to aspartate (p.Ala1293Asp).	Aspartic Acid	162-171	WD repeat domain 62	Homo sapiens	93-98
28027879-4	2017	Heterologous expression of SLC22A11 in human 293 cells gave rise to a huge unidirectional efflux of glutamate (Glu) and aspartate, as determined by LC-MS/MS.	Aspartic Acid	120-129	solute carrier family 22 member 11	Homo sapiens	27-35
28040476-1	2017	The affinity of ligands for G-protein-coupled receptors (GPCRs) is allosterically regulated by Na+ via a highly conserved aspartate residue (Asp2.50) in the second transmembrane domain of GPCRs.	Aspartic Acid	122-131	beta-secretase 1	Homo sapiens	141-145
28193731-4	2017	We show that, besides the osmolytes taurine and myo-inositol, LRRC8 channels transport the neurotransmitters glutamate, aspartate and gamma-aminobutyric acid (GABA) and the co-activator D-serine.	Aspartic Acid	120-129	leucine rich repeat containing 8 VRAC subunit A	Homo sapiens	62-67
28434301-0	2017	An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.	Aspartic Acid	3-6	beta-2-microglobulin	Homo sapiens	45-65
28052935-5	2017	We identified two critical amino acid residues within the PH domain of SKAP55, aspartic acid 120 (D120) and lysine 152 (K152).	Aspartic Acid	79-92	src kinase associated phosphoprotein 1	Homo sapiens	71-77
28287443-2	2017	Here, patatin (40 kDa) was extracted from potato fruit juice using ammonium sulfate precipitation (ASP) and exposed to high hydrostatic pressure (HHP) treatment (250, 350, 450, and 550 MPa).	Aspartic Acid	99-102	Patatin class I	Solanum tuberosum	6-13
28207246-4	2017	We report here that OGT glycosylates aspartate much faster than it glycosylates glutamate in an otherwise identical model peptide substrate; moreover, once formed, the glycosyl aspartate reacts further to form a succinimide intermediate that hydrolyzes to produce the corresponding isoaspartyl peptide.	Aspartic Acid	37-46	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	20-23
28207246-7	2017	In addition to OGT, enzymes that may catalyze aspartate to isoaspartate isomerization include PARPs, enzymes known to ribosylate aspartate residues in the process of poly(ADP-ribosyl)ation.	Aspartic Acid	46-55	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	15-18
28207246-7	2017	In addition to OGT, enzymes that may catalyze aspartate to isoaspartate isomerization include PARPs, enzymes known to ribosylate aspartate residues in the process of poly(ADP-ribosyl)ation.	Aspartic Acid	62-71	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	15-18
28326087-5	2017	Overexpression of AtJUB1 in tomato delays fruit ripening, which is accompanied by reduced expression of several ripening-related genes, and leads to an increase in the levels of various amino acids (mostly proline, beta-alanine, and phenylalanine), gamma-aminobutyric acid (GABA), and major organic acids including glutamic acid and aspartic acid.	Aspartic Acid	333-346	NAC domain containing protein 42	Arabidopsis thaliana	18-24
27789348-3	2017	Molecular dynamics (MD) simulations of galactokinase with the active site residues Arg-37 and Asp-186 altered predicted that two regions (residues 174-179 and 231-240) had different dynamics as a consequence.	Aspartic Acid	94-97	galactokinase 1	Homo sapiens	39-52
27908619-2	2017	MATERIALS AND METHODS: A total of 109 patients with stage IIIA and IIIB NSCLC were prospectively genotyped to examine a potential association between XPD 312 (aspartic acid [Asp]/asparagine [Asn]), XPD 751 (lysine [Lys]/glutamine [Gln]), and RRM1 (-37 C/A) polymorphisms with response and survival.	Aspartic Acid	159-172	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	150-153
28361419-5	2017	Patients with metabolic syndrome carrying genotype Asp/Asp had higher serum endothelin-1 level in comparison with Glu/Asp and Glu/Glu carriers.	Aspartic Acid	51-54	endothelin 1	Homo sapiens	76-88
28361419-5	2017	Patients with metabolic syndrome carrying genotype Asp/Asp had higher serum endothelin-1 level in comparison with Glu/Asp and Glu/Glu carriers.	Aspartic Acid	55-58	endothelin 1	Homo sapiens	76-88
28361419-5	2017	Patients with metabolic syndrome carrying genotype Asp/Asp had higher serum endothelin-1 level in comparison with Glu/Asp and Glu/Glu carriers.	Aspartic Acid	55-58	endothelin 1	Homo sapiens	76-88
27908619-4	2017	In addition, event-free survival was longer for patients with the XPD 312 Asp/Asp genotype compared with patients with Asp/Asn or Asn/Asn (P = .03).	Aspartic Acid	74-77	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	66-69
27908619-4	2017	In addition, event-free survival was longer for patients with the XPD 312 Asp/Asp genotype compared with patients with Asp/Asn or Asn/Asn (P = .03).	Aspartic Acid	78-81	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	66-69
27986533-3	2017	In the mature LPO, the heme moiety is linked to protein through two ester bonds with highly conserved glutamate and aspartate residues.	Aspartic Acid	116-125	lactoperoxidase	Bos taurus	14-17
28003343-4	2017	This finding fits perfectly to the unique cleavage specificity of meprin beta with a strong preference for aspartate residues and suggests coevolution of protease and substrate.	Aspartic Acid	107-116	meprin 1 beta	Mus musculus	66-77
27908619-4	2017	In addition, event-free survival was longer for patients with the XPD 312 Asp/Asp genotype compared with patients with Asp/Asn or Asn/Asn (P = .03).	Aspartic Acid	78-81	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	66-69
27908619-3	2017	RESULTS: The median survival was 32.14 months for carriers of XPD 312 Asp/Asp and 12.04 months for those with the variant Asn allele (P = .05).	Aspartic Acid	70-73	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	62-65
27903463-6	2017	Structural analysis of HER2 TMD association revealed that mutations at positions V659 and G660 to the highly polar residues glutamic acid, aspartic acid, or arginine should stabilize homodimerization and heterodimerization of HER2 in the active conformation.	Aspartic Acid	139-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
27903463-6	2017	Structural analysis of HER2 TMD association revealed that mutations at positions V659 and G660 to the highly polar residues glutamic acid, aspartic acid, or arginine should stabilize homodimerization and heterodimerization of HER2 in the active conformation.	Aspartic Acid	139-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	226-230
28349780-5	2017	The receptor-based molecular docking reveals the best binding interaction of nuclear factor erythroid 2-related factor 2 and ganoderic acid A with GScore (-9.69) (kcal/mol), Lipophilic EvdW (-1.83), Electro (-0.72), Glide emodel (-73.369), H bond (-1.1), molecular mechanics/generalized Born surface area (-75.541) with Leu 718, Asp 800, Cys 797 residues involved in hydrogen bonding.	Aspartic Acid	329-332	NFE2 like bZIP transcription factor 2	Homo sapiens	77-120
28097289-7	2017	Notably, we found that subset 4 IG binding to memory B lymphocytes depends on an aspartic acid at position 66 of FR3 in the rearranged IGKV2-30 gene; this amino acid residue is acquired by somatic mutation.	Aspartic Acid	81-94	immunoglobulin kappa variable 2-30	Homo sapiens	135-143
28000043-2	2017	Three missense mutations for glycine 426 (by standard nomenclature) of TNSALP have been reported: cysteine (p.G426C), serine (p.G426S), and aspartate (p.G426D).	Aspartic Acid	140-149	alkaline phosphatase, biomineralization associated	Homo sapiens	71-77
28000043-5	2017	TNSALP (WT) was mainly present as a 140 kDa catalytically active dimeric form, whereas ~80 kDa monomers were the predominant molecular species in the cells expressing TNSALP (p.G426D) or TNSALP (p.G426S), suggesting that aspartate or serine at position 426 may hamper the subunit assembly essential for the enzymatic function of TNSALP.	Aspartic Acid	221-230	alkaline phosphatase, biomineralization associated	Homo sapiens	0-6
29296957-2	2017	The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction.	Aspartic Acid	132-135	fibrinogen beta chain	Homo sapiens	28-38
28204548-2	2017	It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzyme.	Aspartic Acid	79-82	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	174-203
28204548-2	2017	It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzyme.	Aspartic Acid	79-82	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	205-208
28245869-9	2017	L-asparaginase, an enzyme that catalyzes the hydrolysis of asparagine and glutamine to aspartic acid and glutamate, respectively, mimics the effect of glutamine withdrawal and also diminished the proportion of SP cells.	Aspartic Acid	87-100	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
29296957-2	2017	The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction.	Aspartic Acid	132-135	fibrinogen beta chain	Homo sapiens	190-200
29296957-2	2017	The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction.	Aspartic Acid	132-135	fibrinogen beta chain	Homo sapiens	190-200
29296957-2	2017	The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction.	Aspartic Acid	132-135	fibrinogen beta chain	Homo sapiens	190-200
28114303-11	2017	Moreover, a conserved aspartate residue trigger was found to affect mitochondrial elongation in MFN1, probably through a GTP-loading-dependent domain rearrangement.	Aspartic Acid	22-31	mitofusin 1	Homo sapiens	96-100
28049756-6	2017	Additionally, these S/T-P sites seem to be important for PRRXL1 conformation, and their point mutation to alanine or aspartate down-regulates PRRXL1 transcriptional activity.	Aspartic Acid	117-126	paired related homeobox protein-like 1	Mus musculus	57-63
28049756-6	2017	Additionally, these S/T-P sites seem to be important for PRRXL1 conformation, and their point mutation to alanine or aspartate down-regulates PRRXL1 transcriptional activity.	Aspartic Acid	117-126	paired related homeobox protein-like 1	Mus musculus	142-148
28031466-7	2017	Mutagenesis of Nef amino acids Arg-134, Glu-174, and Asp-175, which stabilize Nef for AP-2 alpha-sigma2 binding in a recent co-crystal structure, substantially reduced AP-2 interaction without affecting CD4 binding.	Aspartic Acid	53-56	S100 calcium binding protein B	Homo sapiens	15-18
28031466-7	2017	Mutagenesis of Nef amino acids Arg-134, Glu-174, and Asp-175, which stabilize Nef for AP-2 alpha-sigma2 binding in a recent co-crystal structure, substantially reduced AP-2 interaction without affecting CD4 binding.	Aspartic Acid	53-56	Nef	Human immunodeficiency virus 1	78-81
28031466-7	2017	Mutagenesis of Nef amino acids Arg-134, Glu-174, and Asp-175, which stabilize Nef for AP-2 alpha-sigma2 binding in a recent co-crystal structure, substantially reduced AP-2 interaction without affecting CD4 binding.	Aspartic Acid	53-56	adaptor related protein complex 2 subunit alpha 1	Homo sapiens	86-96
28031466-7	2017	Mutagenesis of Nef amino acids Arg-134, Glu-174, and Asp-175, which stabilize Nef for AP-2 alpha-sigma2 binding in a recent co-crystal structure, substantially reduced AP-2 interaction without affecting CD4 binding.	Aspartic Acid	53-56	transcription factor AP-2 alpha	Homo sapiens	86-90
28035004-8	2017	Analyses of bond lengths with high-resolution X-ray data and the relationship between the structure and enzymatic activity revealed that hMTH1 recognizes the different oxidized nucleotides via an exchange of the protonation state at two neighboring aspartate residues (Asp-119 and Asp-120) in its substrate binding pocket.	Aspartic Acid	249-258	nudix hydrolase 1	Homo sapiens	137-142
28110537-5	2017	We also confirmed this prediction by measuring dimeric cRGD (cyclic Arg-Gly-Asp) unbinding from integrin (alphavbeta3) using atomic force microscopy-based single-molecule force spectroscopy.	Aspartic Acid	76-79	integrin subunit alpha V	Homo sapiens	96-117
28035004-8	2017	Analyses of bond lengths with high-resolution X-ray data and the relationship between the structure and enzymatic activity revealed that hMTH1 recognizes the different oxidized nucleotides via an exchange of the protonation state at two neighboring aspartate residues (Asp-119 and Asp-120) in its substrate binding pocket.	Aspartic Acid	269-272	nudix hydrolase 1	Homo sapiens	137-142
28035004-8	2017	Analyses of bond lengths with high-resolution X-ray data and the relationship between the structure and enzymatic activity revealed that hMTH1 recognizes the different oxidized nucleotides via an exchange of the protonation state at two neighboring aspartate residues (Asp-119 and Asp-120) in its substrate binding pocket.	Aspartic Acid	281-284	nudix hydrolase 1	Homo sapiens	137-142
27890529-5	2017	Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate.	Aspartic Acid	159-168	pyruvate carboxylase	Homo sapiens	7-9
28154142-5	2017	We further show that the exchange activity of the human Na+/H+ exchanger NHA2 (SLC9B2) is electroneutral, despite harboring the two conserved aspartic acid residues found in NapA and other bacterial homologues.	Aspartic Acid	142-155	solute carrier family 9 member B2	Homo sapiens	73-77
28154142-5	2017	We further show that the exchange activity of the human Na+/H+ exchanger NHA2 (SLC9B2) is electroneutral, despite harboring the two conserved aspartic acid residues found in NapA and other bacterial homologues.	Aspartic Acid	142-155	solute carrier family 9 member B2	Homo sapiens	79-85
27890529-5	2017	Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate.	Aspartic Acid	159-168	pyruvate carboxylase	Homo sapiens	116-118
27531131-1	2017	Canavan disease (CD) is a rare fatal childhood neurological autosomal recessive genetic disease caused by mutations in the ASPA gene, which lead to catalytic deficiency of the ASPA enzyme, which catalyzes the hydrolysis of N-acetyl-L-aspartate (NAA) into aspartate and acetate.	Aspartic Acid	234-243	aspartoacylase	Homo sapiens	123-127
28122815-4	2017	In this study, we show that mutating both Y699 and L701 to alanine, serine, aspartate, or glycine impairs human EAG1 channel function.	Aspartic Acid	76-85	potassium voltage-gated channel subfamily H member 1	Homo sapiens	112-116
27531131-1	2017	Canavan disease (CD) is a rare fatal childhood neurological autosomal recessive genetic disease caused by mutations in the ASPA gene, which lead to catalytic deficiency of the ASPA enzyme, which catalyzes the hydrolysis of N-acetyl-L-aspartate (NAA) into aspartate and acetate.	Aspartic Acid	234-243	aspartoacylase	Homo sapiens	176-180
27872062-7	2017	Aspartic acid residue 1140 in the Drk1 receiver domain was required for in vivo phosphatase activity on Ypd1, and Hog1 was required for drug effect, indicating fidelity in HHK-dependent drug action.	Aspartic Acid	0-13	Ypd1p	Saccharomyces cerevisiae S288C	104-108
27836335-5	2017	The F388L mutation locates adjacent to the critical catalytic aspartate site (D385) of PS1.	Aspartic Acid	62-71	presenilin 1	Homo sapiens	87-90
31457226-0	2017	Isomeric Replacement of a Single Aspartic Acid Induces a Marked Change in Protein Function: The Example of Ribonuclease A.	Aspartic Acid	33-46	ribonuclease pancreatic	Bos taurus	107-121
28150868-0	2017	Identification of second arginine-glycine-aspartic acid motif of ovine vitronectin as the complement C9 binding site and its implication in bacterial infection.	Aspartic Acid	42-55	vitronectin	Capra hircus	71-82
27991616-0	2017	ATB0,+ transporter-mediated targeting delivery to human lung cancer cells via aspartate-modified docetaxel-loading stealth liposomes.	Aspartic Acid	78-87	solute carrier family 1 member 5	Homo sapiens	0-4
27991616-3	2017	In this study, stealth liposomal systems functionalized with aspartate-polyoxyethylene stearate conjugate (APS) were developed for transporter-mediated targeted delivery to ATB0,+, which is overexpressed human lung cells.	Aspartic Acid	61-70	solute carrier family 1 member 5	Homo sapiens	173-177
27991616-10	2017	These results demonstrated that the aspartate-modified liposomes could be a promising nanocarrier for ATB0,+ transporter-mediated targeted drug delivery to treat lung cancer.	Aspartic Acid	36-45	solute carrier family 1 member 5	Homo sapiens	102-106
27899452-6	2017	The structure highlights the key role played by Asp-558 at the extended loop of the CBS2 motif of CNNM2 in maintaining the association between the two proteins and proves that the interaction between CNNM2 and PRL-1 occurs via the catalytic domain of the phosphatase.	Aspartic Acid	48-51	cyclin and CBS domain divalent metal cation transport mediator 2	Homo sapiens	98-103
27908733-8	2017	Intriguingly, substitutions of serine residues in L1MRP1 by aspartic acid, but not alanine, abolished its binding to tubulin, suggesting that phosphorylation of Ser871, 915, 930, and 961 within L1MRP1 may modulate its binding to tubulin.	Aspartic Acid	60-73	immunoglobulin kappa variable 1-16	Homo sapiens	50-56
27899452-6	2017	The structure highlights the key role played by Asp-558 at the extended loop of the CBS2 motif of CNNM2 in maintaining the association between the two proteins and proves that the interaction between CNNM2 and PRL-1 occurs via the catalytic domain of the phosphatase.	Aspartic Acid	48-51	cyclin and CBS domain divalent metal cation transport mediator 2	Homo sapiens	200-205
27899452-6	2017	The structure highlights the key role played by Asp-558 at the extended loop of the CBS2 motif of CNNM2 in maintaining the association between the two proteins and proves that the interaction between CNNM2 and PRL-1 occurs via the catalytic domain of the phosphatase.	Aspartic Acid	48-51	protein tyrosine phosphatase 4A1	Homo sapiens	210-215
27903963-8	2017	In contrast, replacement of S403 and T433 with phosphomimetic aspartic acid to generate a pseudophosphorylated E2F1 mutant protein (E2F1 ST/D) generates a protein that is regulated in a manner indistinguishable from that of wild type E2F1.	Aspartic Acid	62-75	E2F transcription factor 1	Homo sapiens	132-136
27903963-8	2017	In contrast, replacement of S403 and T433 with phosphomimetic aspartic acid to generate a pseudophosphorylated E2F1 mutant protein (E2F1 ST/D) generates a protein that is regulated in a manner indistinguishable from that of wild type E2F1.	Aspartic Acid	62-75	E2F transcription factor 1	Homo sapiens	111-115
27840050-8	2017	A mutation mimicking the phosphorylated serine residue by aspartate substitution (S308D) changed CDKL5 localization to the cytosol, whereas the corresponding alanine-substituted analog, CDKL5(S308A), was primarily localized to the nucleus.	Aspartic Acid	58-67	cyclin-dependent kinase-like 5	Mus musculus	97-102
27903963-8	2017	In contrast, replacement of S403 and T433 with phosphomimetic aspartic acid to generate a pseudophosphorylated E2F1 mutant protein (E2F1 ST/D) generates a protein that is regulated in a manner indistinguishable from that of wild type E2F1.	Aspartic Acid	62-75	E2F transcription factor 1	Homo sapiens	132-136
28077719-2	2017	The lack of functional ASPA, an enzyme enriched in oligodendroglia that cleaves N-acetyl-l-aspartate (NAA) to acetate and l-aspartic acid, elevates brain NAA and causes "spongiform" vacuolation of superficial brain white matter and neighboring gray matter.	Aspartic Acid	122-137	aspartoacylase	Mus musculus	23-27
27875312-8	2017	CXCL12 binding required key residues Asp-1794.60 and Asp-2756.58 (residue numbering follows the Ballesteros-Weinstein scheme), with no evident involvement of N-terminal residues, suggesting an uncommon mode of receptor engagement.	Aspartic Acid	37-40	C-X-C motif chemokine ligand 12	Homo sapiens	0-6
27875312-8	2017	CXCL12 binding required key residues Asp-1794.60 and Asp-2756.58 (residue numbering follows the Ballesteros-Weinstein scheme), with no evident involvement of N-terminal residues, suggesting an uncommon mode of receptor engagement.	Aspartic Acid	53-56	C-X-C motif chemokine ligand 12	Homo sapiens	0-6
27751198-0	2017	Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus.	Aspartic Acid	11-24	major prion protein	Capra hircus	55-59
28013347-9	2017	Finally, we demonstrated the direct interaction between Ang II and MD2 protein via hydrogen bonds on Arg-90, Glu-92, and Asp-100.	Aspartic Acid	121-124	angiotensinogen	Rattus norvegicus	56-62
28013347-9	2017	Finally, we demonstrated the direct interaction between Ang II and MD2 protein via hydrogen bonds on Arg-90, Glu-92, and Asp-100.	Aspartic Acid	121-124	lymphocyte antigen 96	Rattus norvegicus	67-70
27798957-9	2017	Interestingly, the binding between mAb-1 and cathepsin D was weaker than that of mAb-6, which may be related to the fact that two aspartic acid residues near the LYY motif in mAb-1 are replaced with neutral serine residues in mAb-6.	Aspartic Acid	130-143	cathepsin D	Cricetulus griseus	45-56
29055942-9	2017	In NaDC3-expressing oocytes, all dicarboxylates induced much larger inward currents than did L-aspartate and L-glutamate.	Aspartic Acid	93-104	solute carrier family 13 member 3	Homo sapiens	3-8
28064564-0	2017	Aspartate inhibits LPS-induced MAFbx and MuRF1 expression in skeletal muscle in weaned pigs by regulating Akt, AMPKalpha and FOXO1.	Aspartic Acid	0-9	F-box protein 32	Sus scrofa	31-36
28064564-0	2017	Aspartate inhibits LPS-induced MAFbx and MuRF1 expression in skeletal muscle in weaned pigs by regulating Akt, AMPKalpha and FOXO1.	Aspartic Acid	0-9	AKT serine/threonine kinase 1	Sus scrofa	106-109
28064564-0	2017	Aspartate inhibits LPS-induced MAFbx and MuRF1 expression in skeletal muscle in weaned pigs by regulating Akt, AMPKalpha and FOXO1.	Aspartic Acid	0-9	forkhead box O1	Sus scrofa	125-130
28064564-10	2017	Moreover, Asp decreased phosphorylation of AMPKalpha but increased phosphorylation of Akt and Forkhead Box O (FOXO) 1 in the muscles.	Aspartic Acid	10-13	AKT serine/threonine kinase 1	Sus scrofa	86-89
28064564-10	2017	Moreover, Asp decreased phosphorylation of AMPKalpha but increased phosphorylation of Akt and Forkhead Box O (FOXO) 1 in the muscles.	Aspartic Acid	10-13	forkhead box O1	Sus scrofa	94-117
28942093-2	2017	The genetic analysis performed on our proband showed a novel homozygous mutation on codon 119 of lecithin-cholesterol acyltransferase gene that causes the substitution of glycine by aspartate.	Aspartic Acid	182-191	lecithin-cholesterol acyltransferase	Homo sapiens	97-133
28250719-1	2017	Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions.	Aspartic Acid	132-145	somatostatin	Homo sapiens	8-20
27834209-6	2017	They also revealed intercellular concentration gradients of aspartate, alanine, and phosphenolpyruvate to drive a second phosphoenolpyruvate carboxykinase (PEPCK)-type shuttle, which carries 10-14% of the carbon into the bundle sheath.	Aspartic Acid	60-69	phosphoenolpyruvate carboxykinase (ATP)	Zea mays	121-154
27834209-6	2017	They also revealed intercellular concentration gradients of aspartate, alanine, and phosphenolpyruvate to drive a second phosphoenolpyruvate carboxykinase (PEPCK)-type shuttle, which carries 10-14% of the carbon into the bundle sheath.	Aspartic Acid	60-69	phosphoenolpyruvate carboxykinase (ATP)	Zea mays	156-161
27328810-0	2017	Different HIV-1 env frames: gp120 and ASP (antisense protein) biosynthesis, and theirs co-variation tropic amino acid signatures in X4- and R5-viruses.	Aspartic Acid	38-41	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	16-19
27328810-4	2017	Knowing the Env markers of viral tropism, a dataset of sequences (660 strains) was used to analyze the hypothetical ASP involvement in CCR5 (R5) and/or CXCR4 (X4) co-receptor interaction.	Aspartic Acid	116-119	endogenous retrovirus group K member 20	Homo sapiens	12-15
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Aspartic Acid	69-72	CD4 molecule	Homo sapiens	14-17
27328810-4	2017	Knowing the Env markers of viral tropism, a dataset of sequences (660 strains) was used to analyze the hypothetical ASP involvement in CCR5 (R5) and/or CXCR4 (X4) co-receptor interaction.	Aspartic Acid	116-119	C-C motif chemokine receptor 5	Homo sapiens	135-139
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Aspartic Acid	69-72	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	76-81
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Aspartic Acid	69-72	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	127-132
27328810-10	2017	These results show that gp120V3 and specific amino acid changes in ASP are associated together with CXCR4 and/or CCR5-usage.	Aspartic Acid	67-70	C-X-C motif chemokine receptor 4	Homo sapiens	100-105
27328810-10	2017	These results show that gp120V3 and specific amino acid changes in ASP are associated together with CXCR4 and/or CCR5-usage.	Aspartic Acid	67-70	C-C motif chemokine receptor 5	Homo sapiens	113-117
27858371-3	2017	We have identified a pair of siblings with mutations in FBXL4 who each presented in the neonatal period with hyperammonemia, low plasma levels of aspartate, low urine levels of tricarboxylic acid cycle intermediates suggesting a defect in anaplerosis, and cerebellar hypoplasia in addition to lactic acidosis and other classic signs of mitochondrial encephalomyopathy.	Aspartic Acid	146-155	F-box and leucine rich repeat protein 4	Homo sapiens	56-61
27917477-6	2017	Putative Zn2+ -binding motifs within SV31 comprise aspartic acid and histidine residues.	Aspartic Acid	51-64	transmembrane protein 163	Homo sapiens	37-41
27770926-3	2017	The PHA-g-AA/TASP membranes had better mechanical properties than the PHA/ASP membrane.	Aspartic Acid	14-17	lamin B receptor	Homo sapiens	4-12
27770926-3	2017	The PHA-g-AA/TASP membranes had better mechanical properties than the PHA/ASP membrane.	Aspartic Acid	14-17	lamin B receptor	Homo sapiens	4-7
27770926-7	2017	PHA-g-AA/TASP and PHA/ASP membranes had better antioxidant activity than the control group.	Aspartic Acid	10-13	lamin B receptor	Homo sapiens	0-8
27770926-7	2017	PHA-g-AA/TASP and PHA/ASP membranes had better antioxidant activity than the control group.	Aspartic Acid	10-13	lamin B receptor	Homo sapiens	0-3
28063500-3	2017	cPLA2alpha is composed of an N-terminal C2 domain and a C-terminal catalytic domain that contains the Ser-Asp catalytic dyad.	Aspartic Acid	106-109	phospholipase A2 group IVA	Homo sapiens	0-10
27939849-10	2017	A PEST (rich in Pro, Glu/Asp, Ser, and Thr) sequence-dependent endoplasmic reticulum-associated protein degradation (ERAD) mechanism was established to decrease cellular levels of Erg9p without relying on inducers, repressors or specific repressing conditions.	Aspartic Acid	25-28	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	180-185
27761847-3	2017	Recently, the role of alphav integrins, which recognize the Arg-Gly-Asp (RGD) tripeptide, in the release and signal transduction activation of TGFbeta1 became evident.	Aspartic Acid	68-71	transforming growth factor beta 1	Homo sapiens	143-151
29147463-3	2017	The results showed that ASP inhibited inflammatory hepcidin in both HepG2 cells and ACD rats by blocking the IL-6/STAT3 and BMP/SMAD pathways.	Aspartic Acid	24-27	hepcidin antimicrobial peptide	Homo sapiens	51-59
27401256-1	2017	The mitochondrial aspartate/glutamate transporter Aralar/AGC1/Slc25a12 is critically involved in brain aspartate synthesis, and AGC1 deficiency results in a drastic fall of brain aspartate levels in humans and mice.	Aspartic Acid	18-27	solute carrier family 25 member 12	Homo sapiens	50-56
27401256-1	2017	The mitochondrial aspartate/glutamate transporter Aralar/AGC1/Slc25a12 is critically involved in brain aspartate synthesis, and AGC1 deficiency results in a drastic fall of brain aspartate levels in humans and mice.	Aspartic Acid	18-27	solute carrier family 25 member 12	Homo sapiens	57-61
27401256-1	2017	The mitochondrial aspartate/glutamate transporter Aralar/AGC1/Slc25a12 is critically involved in brain aspartate synthesis, and AGC1 deficiency results in a drastic fall of brain aspartate levels in humans and mice.	Aspartic Acid	18-27	solute carrier family 25 member 12	Homo sapiens	62-70
27401256-1	2017	The mitochondrial aspartate/glutamate transporter Aralar/AGC1/Slc25a12 is critically involved in brain aspartate synthesis, and AGC1 deficiency results in a drastic fall of brain aspartate levels in humans and mice.	Aspartic Acid	103-112	solute carrier family 25 member 12	Homo sapiens	50-56
27401256-1	2017	The mitochondrial aspartate/glutamate transporter Aralar/AGC1/Slc25a12 is critically involved in brain aspartate synthesis, and AGC1 deficiency results in a drastic fall of brain aspartate levels in humans and mice.	Aspartic Acid	103-112	solute carrier family 25 member 12	Homo sapiens	57-61
27401256-1	2017	The mitochondrial aspartate/glutamate transporter Aralar/AGC1/Slc25a12 is critically involved in brain aspartate synthesis, and AGC1 deficiency results in a drastic fall of brain aspartate levels in humans and mice.	Aspartic Acid	103-112	solute carrier family 25 member 12	Homo sapiens	62-70
27401256-2	2017	It has recently been described that the uncoupling protein UCP2 transports four carbon metabolites including aspartate.	Aspartic Acid	109-118	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	59-63
27401256-3	2017	Since UCP2 is expressed in several brain cell types and AGC1 is mainly neuronal, we set to test whether UCP2 could be a mitochondrial aspartate carrier in the brain glial compartment.	Aspartic Acid	134-143	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	104-108
27816769-2	2017	The physiological role of DARS in translation is to accurately pair aspartate with its cognate tRNA.	Aspartic Acid	68-77	aspartyl-tRNA synthetase	Mus musculus	26-30
29147463-3	2017	The results showed that ASP inhibited inflammatory hepcidin in both HepG2 cells and ACD rats by blocking the IL-6/STAT3 and BMP/SMAD pathways.	Aspartic Acid	24-27	interleukin 6	Rattus norvegicus	109-113
29147463-3	2017	The results showed that ASP inhibited inflammatory hepcidin in both HepG2 cells and ACD rats by blocking the IL-6/STAT3 and BMP/SMAD pathways.	Aspartic Acid	24-27	signal transducer and activator of transcription 3	Rattus norvegicus	114-119
29147463-4	2017	In ACD rats, the administration of ASP increased ferroportin expression, mobilized iron from the liver and spleen, increased serum iron levels, caused an elevation of serum EPO, and effectively relieved the anemia.	Aspartic Acid	35-38	erythropoietin	Rattus norvegicus	173-176
29147463-5	2017	Furthermore, ASP inhibited NF-kappaB p65 activation via the IkappaB kinases- (IKKs-) IkappaBalpha pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-alpha, which is known to inhibit erythropoiesis.	Aspartic Acid	13-16	nuclear factor kappa B subunit 1	Homo sapiens	27-36
29147463-5	2017	Furthermore, ASP inhibited NF-kappaB p65 activation via the IkappaB kinases- (IKKs-) IkappaBalpha pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-alpha, which is known to inhibit erythropoiesis.	Aspartic Acid	13-16	RELA proto-oncogene, NF-kB subunit	Homo sapiens	37-40
29147463-5	2017	Furthermore, ASP inhibited NF-kappaB p65 activation via the IkappaB kinases- (IKKs-) IkappaBalpha pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-alpha, which is known to inhibit erythropoiesis.	Aspartic Acid	13-16	interleukin 6	Homo sapiens	141-154
29147463-5	2017	Furthermore, ASP inhibited NF-kappaB p65 activation via the IkappaB kinases- (IKKs-) IkappaBalpha pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-alpha, which is known to inhibit erythropoiesis.	Aspartic Acid	13-16	interleukin 6	Homo sapiens	156-160
29147463-5	2017	Furthermore, ASP inhibited NF-kappaB p65 activation via the IkappaB kinases- (IKKs-) IkappaBalpha pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-alpha, which is known to inhibit erythropoiesis.	Aspartic Acid	13-16	tumor necrosis factor	Homo sapiens	166-175
28197209-8	2017	And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.	Aspartic Acid	30-33	bone morphogenetic protein 2	Homo sapiens	75-80
28197209-8	2017	And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.	Aspartic Acid	30-33	bone morphogenetic protein 2	Homo sapiens	126-131
27929535-4	2016	GLS1 remarkably contributes to ATP production through transferring cytosolic NADH into mitochondria via malate-aspartate shuttle by supply of glutamate in NSCLC.	Aspartic Acid	111-120	glutaminase	Homo sapiens	0-4
27789710-3	2016	To shed light on the mechanistic basis for these observations, we determined the crystal structure of SpvD and show that it adopts a papain-like fold with a characteristic cysteine-histidine-aspartate catalytic triad comprising Cys-73, His-162, and Asp-182.	Aspartic Acid	191-200	Salmonella plasmid virulence protein D	Salmonella enterica subsp. enterica serovar Typhimurium	102-106
27789710-3	2016	To shed light on the mechanistic basis for these observations, we determined the crystal structure of SpvD and show that it adopts a papain-like fold with a characteristic cysteine-histidine-aspartate catalytic triad comprising Cys-73, His-162, and Asp-182.	Aspartic Acid	249-252	Salmonella plasmid virulence protein D	Salmonella enterica subsp. enterica serovar Typhimurium	102-106
29358954-8	2017	Results: Npnt mediates hDPSC adhesion and spreading partially via the Arg-Gly-Asp (RGD) motif.	Aspartic Acid	78-81	nephronectin	Homo sapiens	9-13
29376577-3	2017	Citrin deficiency is an autosomal recessive metabolic disorder, which is caused by pathogenic mutations in the SLC25A13 gene on chromosome 7q21.3, as the causative gene that encodes the liver type aspartate/glutamate carrier isoform 2 (AGC2).	Aspartic Acid	197-206	solute carrier family 25 member 13	Homo sapiens	111-119
27929535-5	2016	Regulation of malate-aspartate shuttle by knockdown or inhibition of glutamic-oxaloacetic transaminase 2 or malate dehydrogenase 2 mimicked GLS1 knockdown, which induced cell death with ATP reduction in NSCLC.	Aspartic Acid	21-30	glutamic-oxaloacetic transaminase 2	Homo sapiens	69-104
27929535-5	2016	Regulation of malate-aspartate shuttle by knockdown or inhibition of glutamic-oxaloacetic transaminase 2 or malate dehydrogenase 2 mimicked GLS1 knockdown, which induced cell death with ATP reduction in NSCLC.	Aspartic Acid	21-30	glutaminase	Homo sapiens	140-144
27748654-6	2016	Further, using a rat in vivo model of cardiac injury, the TRPA1 activators ASP 7663 and optovin reduce myocardial injury (45 +- 5%* and 44 +- 8%,* respectively, vs. control, 66 +- 6% infarct size/area at risk; n = 6 per group; mean +- SD; *P &lt; 0.001).	Aspartic Acid	75-78	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	58-63
27565657-0	2016	Atypical cleavage of protonated N-fatty acyl amino acids derived from aspartic acid evidenced by sequential MS3 experiments.	Aspartic Acid	70-83	MS3	Homo sapiens	108-111
27813540-8	2016	Moreover, mechanistic studies illustrated that ASP could upregulate the expression of PPARgamma and liver insulin signaling proteins, including IRS-2, PI3K, Akt, p-Akt and GLUT2, increase anti-apoptotic protein Bcl-2, decrease pro-apoptotic protein Bax expressions, and protect the mice against hepatic damage.	Aspartic Acid	47-50	peroxisome proliferator activated receptor gamma	Mus musculus	86-95
27813540-8	2016	Moreover, mechanistic studies illustrated that ASP could upregulate the expression of PPARgamma and liver insulin signaling proteins, including IRS-2, PI3K, Akt, p-Akt and GLUT2, increase anti-apoptotic protein Bcl-2, decrease pro-apoptotic protein Bax expressions, and protect the mice against hepatic damage.	Aspartic Acid	47-50	insulin receptor substrate 2	Mus musculus	144-149
27813540-8	2016	Moreover, mechanistic studies illustrated that ASP could upregulate the expression of PPARgamma and liver insulin signaling proteins, including IRS-2, PI3K, Akt, p-Akt and GLUT2, increase anti-apoptotic protein Bcl-2, decrease pro-apoptotic protein Bax expressions, and protect the mice against hepatic damage.	Aspartic Acid	47-50	thymoma viral proto-oncogene 1	Mus musculus	157-160
27813540-8	2016	Moreover, mechanistic studies illustrated that ASP could upregulate the expression of PPARgamma and liver insulin signaling proteins, including IRS-2, PI3K, Akt, p-Akt and GLUT2, increase anti-apoptotic protein Bcl-2, decrease pro-apoptotic protein Bax expressions, and protect the mice against hepatic damage.	Aspartic Acid	47-50	thymoma viral proto-oncogene 1	Mus musculus	164-167
27813540-8	2016	Moreover, mechanistic studies illustrated that ASP could upregulate the expression of PPARgamma and liver insulin signaling proteins, including IRS-2, PI3K, Akt, p-Akt and GLUT2, increase anti-apoptotic protein Bcl-2, decrease pro-apoptotic protein Bax expressions, and protect the mice against hepatic damage.	Aspartic Acid	47-50	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	172-177
27813540-8	2016	Moreover, mechanistic studies illustrated that ASP could upregulate the expression of PPARgamma and liver insulin signaling proteins, including IRS-2, PI3K, Akt, p-Akt and GLUT2, increase anti-apoptotic protein Bcl-2, decrease pro-apoptotic protein Bax expressions, and protect the mice against hepatic damage.	Aspartic Acid	47-50	B cell leukemia/lymphoma 2	Mus musculus	211-216
27813540-8	2016	Moreover, mechanistic studies illustrated that ASP could upregulate the expression of PPARgamma and liver insulin signaling proteins, including IRS-2, PI3K, Akt, p-Akt and GLUT2, increase anti-apoptotic protein Bcl-2, decrease pro-apoptotic protein Bax expressions, and protect the mice against hepatic damage.	Aspartic Acid	47-50	BCL2-associated X protein	Mus musculus	249-252
27754869-6	2016	Moreover, we propose that ligand binding triggers translocation of Arg-143 from the membrane interface into the membrane to enable alignment with oppositely charged aspartate residues within CD3zeta and activation of CD3zeta-signaling.	Aspartic Acid	165-174	CD247 molecule	Homo sapiens	191-198
27754869-6	2016	Moreover, we propose that ligand binding triggers translocation of Arg-143 from the membrane interface into the membrane to enable alignment with oppositely charged aspartate residues within CD3zeta and activation of CD3zeta-signaling.	Aspartic Acid	165-174	CD247 molecule	Homo sapiens	217-224
27790731-9	2016	Specifically, metabolites from the nucleotide and amino acid pathway (ribose, glucose-6-phosphate, glutamic acid, aspartic acid, and sedoheptulose-7-P) were elevated in Shp-/- CD + M mice during the dark cycle, whereas metabolites including N-methylalanine, 2-hydroxybutyric acid, and 2-hydroxyglutarate were elevated in WT ED + E mice during the light cycle.	Aspartic Acid	114-127	nuclear receptor subfamily 0, group B, member 2	Mus musculus	169-172
27748654-8	2016	In isolated cardiac myocytes, the TRPA1 activators ASP 7663 and optovin reduce cardiac myocyte cell death when given during reoxygenation (20 +- 3%* and 22 +- 4%* vs. 36 +- 3%; percentage of dead cells per field, n = 6 per group; mean +- SD; *P &lt; 0.05).	Aspartic Acid	51-54	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	34-39
27612916-5	2016	This low-frequency variation, found in two individuals of a population of 305 healthy volunteers, leads to the translation of an asparagine instead of an aspartic acid (UGT2B7 p.D121N).	Aspartic Acid	154-167	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	169-175
27816517-2	2016	The co-crystal structure of a representative thiazinamine 2e bound with the BACE1 active site displayed a binding mode driven by interactions with the catalytic aspartate dyad and engagement of the biaryl amide toward the S1 and S3 pockets.	Aspartic Acid	161-170	beta-secretase 1	Homo sapiens	76-81
27866936-1	2016	l-asparaginase (EC 3.5.1.1) is an enzyme that catalysis mainly the asparagine hydrolysis in l-aspartic acid and ammonium.	Aspartic Acid	92-107	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
27387750-3	2016	We show that mammalian serine racemase (SRR), the primary enzyme responsible for brain d-Ser production, catalyses Asp racemization via a two-base mechanism.	Aspartic Acid	115-118	serine racemase	Homo sapiens	23-38
27545408-9	2016	The TCA cycle metabolic pathways and the alanine, aspartate and glutamate metabolism were identified as significant metabolic pathways involved with SCP.	Aspartic Acid	50-59	cysteine-rich secretory protein 3	Rattus norvegicus	149-152
27387750-3	2016	We show that mammalian serine racemase (SRR), the primary enzyme responsible for brain d-Ser production, catalyses Asp racemization via a two-base mechanism.	Aspartic Acid	115-118	serine racemase	Homo sapiens	40-43
27548707-3	2016	Here, we show that chromatin deformation as well as force-induced transcription of a green fluorescent protein (GFP)-tagged bacterial-chromosome dihydrofolate reductase (DHFR) transgene can be visualized in a living cell by using three-dimensional magnetic twisting cytometry to apply local stresses on the cell surface via an Arg-Gly-Asp-coated magnetic bead.	Aspartic Acid	335-338	dihydrofolate reductase	Homo sapiens	145-168
27548707-3	2016	Here, we show that chromatin deformation as well as force-induced transcription of a green fluorescent protein (GFP)-tagged bacterial-chromosome dihydrofolate reductase (DHFR) transgene can be visualized in a living cell by using three-dimensional magnetic twisting cytometry to apply local stresses on the cell surface via an Arg-Gly-Asp-coated magnetic bead.	Aspartic Acid	335-338	dihydrofolate reductase	Homo sapiens	170-174
27707927-7	2016	The histidine, aspartic acid, and serine residue (HDS) triad of TMPRSS12 was shown to be essential for the proteolysis of aMPV/B F protein via mutation analysis.	Aspartic Acid	15-28	transmembrane serine protease 12	Homo sapiens	64-72
27898714-8	2016	IN CONCLUSION: There is a comparable effectiveness with respect to 28- and 90-days outcome for first week treatment with ASP versus cephalosporin in MS-SAB.	Aspartic Acid	121-124	SH3 domain binding protein 5	Homo sapiens	152-155
27451147-0	2016	SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.	Aspartic Acid	163-172	solute carrier family 25 (mitochondrial carrier, glutamate), member 22	Mus musculus	0-8
27882936-4	2016	Following cleavage, the intersubunit linker (and associated conformational changes) in caspase-9-p35/p12 inhibited its ability to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-330 removed the linker entirely and partially restored activity to caspase-9-p35/p10.	Aspartic Acid	197-200	caspase 9	Homo sapiens	87-96
27882936-4	2016	Following cleavage, the intersubunit linker (and associated conformational changes) in caspase-9-p35/p12 inhibited its ability to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-330 removed the linker entirely and partially restored activity to caspase-9-p35/p10.	Aspartic Acid	197-200	interleukin 12A	Homo sapiens	97-100
27882936-4	2016	Following cleavage, the intersubunit linker (and associated conformational changes) in caspase-9-p35/p12 inhibited its ability to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-330 removed the linker entirely and partially restored activity to caspase-9-p35/p10.	Aspartic Acid	197-200	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	101-104
27882936-4	2016	Following cleavage, the intersubunit linker (and associated conformational changes) in caspase-9-p35/p12 inhibited its ability to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-330 removed the linker entirely and partially restored activity to caspase-9-p35/p10.	Aspartic Acid	197-200	caspase 3	Homo sapiens	184-193
27590359-0	2016	Apelin-36 is protective against N-methyl-D-aspartic-acid-induced retinal ganglion cell death in the mice.	Aspartic Acid	43-56	apelin	Mus musculus	0-6
27824920-5	2016	Electrophysiology experiments also confirm that the aspartate residue at position 915 represents a constriction site of the TRPA1 pore and is critical in controlling ion permeation.	Aspartic Acid	52-61	transient receptor potential cation channel subfamily A member 1	Homo sapiens	124-129
27819732-6	2016	Aspartic acid at the 144th position was more preserved among species than aspartic acid at the 295th position of the VSX1 protein.	Aspartic Acid	74-87	visual system homeobox 1	Homo sapiens	117-121
27828948-6	2016	SMCs lacking Fat1 (Fat1KO) grow faster, consume more oxygen for ATP production, and contain more aspartate.	Aspartic Acid	97-106	FAT atypical cadherin 1	Mus musculus	19-25
27841396-8	2016	However, for the substrate mutant that contains Asp instead of Phe at the C-terminus, one CPA mutant exhibits a reasonable activity, as predicted across the theoretical methods.	Aspartic Acid	48-51	carboxypeptidase A1	Homo sapiens	90-93
27565221-4	2016	We have previously reported the preparation of a novel aspirin derivative that we named Ca-Asp, and showed that it causes less damage to gastric mucosa of rat and inhibits the expression of COX-2 to higher degree than Asp.	Aspartic Acid	91-94	prostaglandin-endoperoxide synthase 2	Homo sapiens	190-195
27895477-1	2016	PURPOSE: Arginine-glycine-aspartic acid (RGD)-based nanoprobes allow specific imaging of integrin alphavbeta3, a protein overexpressed during angiogenesis.	Aspartic Acid	26-39	integrin subunit alpha V	Homo sapiens	89-109
27395800-9	2016	Furthermore, the uptake of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+), a fluorescent OCT2 substrate, was studied in absence and presence of known OCT inhibitors, such as cimetidine and a cationic uremic solutes mixture.	Aspartic Acid	82-86	solute carrier family 22 member 2	Homo sapiens	103-107
27395800-10	2016	The ASP+ uptake by the living upscaled membrane was decreased by 60% in the presence of either inhibitor, proving the active function of OCT2.	Aspartic Acid	4-8	solute carrier family 22 member 2	Homo sapiens	137-141
27451147-5	2016	Expression of SLC25A22 was knocked down in KRAS mutant CRC cell lines (DLD1, HCT116, LOVO, SW480, SW620, and SW1116) and CRC cell lines without mutations in KRAS (CACO-2, COLO205, HT29, and SW48); cells were analyzed for colony formation, proliferation, glutaminolysis and aspartate synthesis, and apoptosis in Matrigel and polymerase chain reaction array analyses.	Aspartic Acid	273-282	solute carrier family 25 member 22	Homo sapiens	14-22
27451147-10	2016	Knockdown of SLC25A22 reduced aspartate biosynthesis, leading to apoptosis, decreased cell proliferation in KRAS mutant CRC cells.	Aspartic Acid	30-39	solute carrier family 25 member 22	Homo sapiens	13-21
27451147-11	2016	Incubation of KRAS mutant CRC cells with knockdown of SLC25A22 with aspartate increased proliferation and reduced apoptosis, which required GOT1, indicating that oxaloacetate is required for cell survival.	Aspartic Acid	68-77	KRAS proto-oncogene, GTPase	Homo sapiens	14-18
27451147-11	2016	Incubation of KRAS mutant CRC cells with knockdown of SLC25A22 with aspartate increased proliferation and reduced apoptosis, which required GOT1, indicating that oxaloacetate is required for cell survival.	Aspartic Acid	68-77	solute carrier family 25 member 22	Homo sapiens	54-62
28361593-2	2016	The following is the first report of a double heterozygosity for Hb Q-Thailand [alpha74(EF3)Asp His; HBA1: c.223G&gt;C] with alpha+-thalassemia (alpha+-thal) and Hb J-Bangkok [beta56(D7)Gly Asp; HBB: c.170G&gt;A] found in a Chinese family.	Aspartic Acid	92-95	hemoglobin subunit alpha 1	Homo sapiens	101-105
27451147-11	2016	Incubation of KRAS mutant CRC cells with knockdown of SLC25A22 with aspartate increased proliferation and reduced apoptosis, which required GOT1, indicating that oxaloacetate is required for cell survival.	Aspartic Acid	68-77	glutamic-oxaloacetic transaminase 1	Homo sapiens	140-144
28361593-2	2016	The following is the first report of a double heterozygosity for Hb Q-Thailand [alpha74(EF3)Asp His; HBA1: c.223G&gt;C] with alpha+-thalassemia (alpha+-thal) and Hb J-Bangkok [beta56(D7)Gly Asp; HBB: c.170G&gt;A] found in a Chinese family.	Aspartic Acid	190-193	hemoglobin subunit alpha 1	Homo sapiens	101-105
27451147-18	2016	SLC25A22 induces intracellular synthesis of aspartate, activation of mitogen-activated protein kinase kinase and extracellular signal-regulated kinase signaling and reduces oxidative stress.	Aspartic Acid	44-53	solute carrier family 25 member 22	Homo sapiens	0-8
32512682-2	2016	However, amino acid sequence analyses suggest that DSPP has lost some common features, but acquired other unique features, such as repeat sequences of serine-serine-aspartic acid (SDrr) that are not observed in other SIBLINGs proteins.	Aspartic Acid	165-178	dentin sialophosphoprotein	Homo sapiens	51-55
27507246-4	2016	TDP-43 over-expression is associated with an increase in glutamate and gamma-amino butyric acid and reduction of glutamine and aspartate levels, indicating impairment of presynaptic terminal.	Aspartic Acid	127-136	TAR DNA binding protein	Mus musculus	0-6
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Aspartic Acid	186-195	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	113-134
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Aspartic Acid	186-195	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	136-140
27764698-5	2016	KRAS mutation causes a marked decrease in aspartate level and an increase in asparagine level in CRC.	Aspartic Acid	42-51	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Aspartic Acid	186-195	KRAS proto-oncogene, GTPase	Homo sapiens	224-228
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Aspartic Acid	186-195	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	238-242
27764698-6	2016	Using several human CRC cell lines and clinical specimens of primary CRC, we demonstrated that the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, was upregulated by mutated KRAS and that ASNS expression was induced by KRAS-activated signaling pathway, in particular PI3K-AKT-mTOR pathway.	Aspartic Acid	186-195	KRAS proto-oncogene, GTPase	Homo sapiens	269-273
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Aspartic Acid	41-44	uroplakin 2	Homo sapiens	78-82
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Aspartic Acid	41-44	uroplakin 2	Homo sapiens	155-159
27741237-2	2016	Transforming growth factor-beta-inducible gene-h3 (betaig-h3), which consists of four fas-1 domains and an Arg-Gly-Asp (RGD) motif, intensifies inflammatory processes by facilitating adhesion and migration of fibroblast-like synoviocyte in the pathogenesis of rheumatoid arthritis (RA).	Aspartic Acid	115-118	transforming growth factor, beta induced	Mus musculus	51-60
27801846-6	2016	When S256 on all four monomers is changed to the phosphomimic aspartic acid (S256D), AQP2-S256D localizes to the plasma membrane and internalization is decreased.	Aspartic Acid	62-75	aquaporin 2	Homo sapiens	85-89
32908392-0	2016	Chicken Ovotransferrin Variants OTFB and OTFC Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity.	Aspartic Acid	77-80	transferrin (ovotransferrin)	Gallus gallus	8-22
27561782-4	2016	And then we biochemically and genetically demonstrated that the 27th Asp was the amino acid that influenced the interaction of VTC1 with CSN5B in plants.	Aspartic Acid	69-72	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	127-131
27561782-4	2016	And then we biochemically and genetically demonstrated that the 27th Asp was the amino acid that influenced the interaction of VTC1 with CSN5B in plants.	Aspartic Acid	69-72	COP9-signalosome 5B	Arabidopsis thaliana	137-142
27561782-5	2016	Moreover, transgenic lines overexpressing the site-specific mutagenesis from D27 (Asp) into E27 (Glu) in VTC1 showed enhanced AsA accumulation and reduced H2O2 content in Arabidopsis seedlings, compared with the lines overexpressing the mutation from D27 into N27 (Asn) in VTC1.	Aspartic Acid	82-85	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	105-109
27561782-5	2016	Moreover, transgenic lines overexpressing the site-specific mutagenesis from D27 (Asp) into E27 (Glu) in VTC1 showed enhanced AsA accumulation and reduced H2O2 content in Arabidopsis seedlings, compared with the lines overexpressing the mutation from D27 into N27 (Asn) in VTC1.	Aspartic Acid	82-85	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	273-277
27577093-4	2016	We cloned zebrafish caspase-3a (casp3a) and examined substrate specificity of the recombinant protein, Casp3a, compared to human caspase-3 (CASP3) by utilizing M13 bacteriophage substrate libraries that incorporated either random amino acids at P5-P1" or aspartate fixed at P1.	Aspartic Acid	255-264	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	103-109
27560372-3	2016	An adjacent aspartate was recently predicted to mediate Nef-beta-catenin interactions.	Aspartic Acid	12-21	S100 calcium binding protein B	Homo sapiens	56-59
27560372-3	2016	An adjacent aspartate was recently predicted to mediate Nef-beta-catenin interactions.	Aspartic Acid	12-21	catenin beta 1	Homo sapiens	60-72
27560372-5	2016	This association is conserved among lentiviral Nef proteins but does not involve classical Nef protein interaction motifs, including the critical aspartate.	Aspartic Acid	146-155	S100 calcium binding protein B	Homo sapiens	47-50
27560372-6	2016	While aspartate-to-alanine mutations impaired cell surface receptor downregulation and interference with actin dynamics and cell motility by HIV-1 NA7 Nef, analogous mutations did not affect HIV-1 SF2 Nef function.	Aspartic Acid	6-15	S100 calcium binding protein B	Homo sapiens	151-154
27732861-0	2016	Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.	Aspartic Acid	13-22	oxoglutarate dehydrogenase	Homo sapiens	91-95
27732861-3	2016	Using an integrative metabolomics approach, we identified differential aspartate utilization, via the malate-aspartate shuttle, as a predictor of whether OGDH is required for proliferation in 3D culture assays and for the growth of xenograft tumors.	Aspartic Acid	71-80	oxoglutarate dehydrogenase	Homo sapiens	154-158
27732861-3	2016	Using an integrative metabolomics approach, we identified differential aspartate utilization, via the malate-aspartate shuttle, as a predictor of whether OGDH is required for proliferation in 3D culture assays and for the growth of xenograft tumors.	Aspartic Acid	109-118	oxoglutarate dehydrogenase	Homo sapiens	154-158
27481099-0	2016	A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.	Aspartic Acid	9-18	REV3 like, DNA directed polymerase zeta catalytic subunit	Mus musculus	63-68
27565992-8	2016	Moreover, a single mutation (aspartate to glycine) at amino acid position 54 in M1 [M1(D54G)] was detected after 18 passages in the presence of KR-23502 with a 2-fold increase in 50% effective concentration indicating that this compound has a relatively high genetic barrier to resistance.	Aspartic Acid	29-38	myoregulin	Homo sapiens	80-82
27565992-8	2016	Moreover, a single mutation (aspartate to glycine) at amino acid position 54 in M1 [M1(D54G)] was detected after 18 passages in the presence of KR-23502 with a 2-fold increase in 50% effective concentration indicating that this compound has a relatively high genetic barrier to resistance.	Aspartic Acid	29-38	myoregulin	Homo sapiens	84-86
27132995-1	2016	In this review we discuss the structure and functions of the aspartate/glutamate carriers (AGC1-aralar and AGC2-citrin).	Aspartic Acid	61-70	solute carrier family 25 member 13	Homo sapiens	112-118
26510381-3	2016	In this study, we have selected hydroxamic acid derivatives as HDACi and performed fragment-based G-QSAR, molecular docking studies and molecular dynamics simulations for elucidating the dynamic mode of action of HDACi with His-Asp catalytic dyad of HDAC4.	Aspartic Acid	228-231	histone deacetylase 4	Homo sapiens	250-255
26510381-9	2016	The interaction of the compounds with His-Asp dyad in terms of H-bond interactions with His802, Asp840, Pro942, and Gly975 residues of HDAC4 was evaluated by docking and 20 ns long molecular dynamics simulations.	Aspartic Acid	42-45	histone deacetylase 4	Homo sapiens	135-140
26905697-1	2016	PURPOSE: Multimeric arginine-glycine-aspartic acid (RGD) peptides have advantages for imaging integrin alphavbeta3 expression.	Aspartic Acid	37-50	integrin subunit alpha V	Homo sapiens	94-114
27287393-2	2016	Of the ~90 argininosuccinate synthetase (ASS) missense mutations reported, 21 map near the substrate (aspartate or citrulline) binding site, and thus are potential kinetic mutations whose decreased activities could be amenable to substrate supplementation.	Aspartic Acid	102-111	argininosuccinate synthase 1	Homo sapiens	41-44
27251594-1	2016	OBJECTIVE: Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine.	Aspartic Acid	125-138	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	11-32
27251594-1	2016	OBJECTIVE: Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine.	Aspartic Acid	125-138	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	34-38
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	NFKB inhibitor zeta	Homo sapiens	18-29
27690308-5	2016	Moreover, we identify a minimal region in the C-terminus of Cac1, including the structured winged helix domain and glutamate/aspartate-rich domain, which is sufficient to induce (H3/H4)2 tetramerization.	Aspartic Acid	125-134	Rlf2p	Saccharomyces cerevisiae S288C	60-64
27510035-4	2016	Over the last decade, several publications have suggested (i) that Ate1 can also arginylate non-canonical N-terminal residues; (ii) that Ate1 is capable of arginylating not only alpha-amino groups of N-terminal residues but also gamma-carboxyl groups of internal (non-N-terminal) Asp and Glu; and (iii) that some isoforms of Ate1 are specific for substrates bearing N-terminal Cys residues.	Aspartic Acid	280-283	arginyltransferase 1	Mus musculus	67-71
27510035-4	2016	Over the last decade, several publications have suggested (i) that Ate1 can also arginylate non-canonical N-terminal residues; (ii) that Ate1 is capable of arginylating not only alpha-amino groups of N-terminal residues but also gamma-carboxyl groups of internal (non-N-terminal) Asp and Glu; and (iii) that some isoforms of Ate1 are specific for substrates bearing N-terminal Cys residues.	Aspartic Acid	280-283	arginyltransferase 1	Mus musculus	137-141
27510035-4	2016	Over the last decade, several publications have suggested (i) that Ate1 can also arginylate non-canonical N-terminal residues; (ii) that Ate1 is capable of arginylating not only alpha-amino groups of N-terminal residues but also gamma-carboxyl groups of internal (non-N-terminal) Asp and Glu; and (iii) that some isoforms of Ate1 are specific for substrates bearing N-terminal Cys residues.	Aspartic Acid	280-283	arginyltransferase 1	Mus musculus	137-141
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	nuclear factor kappa B subunit 1	Homo sapiens	58-61
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	ankyrin 1	Homo sapiens	95-99
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	NFKB inhibitor zeta	Homo sapiens	150-161
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	BCL3 transcription coactivator	Homo sapiens	203-208
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	NFKB inhibitor delta	Homo sapiens	213-222
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	nuclear factor kappa B subunit 1	Homo sapiens	324-327
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	lipocalin 2	Homo sapiens	356-360
27489104-3	2016	Here we show that IkappaBzeta productively interacts with p50 via Asp-451 in the N terminus of ANK1, a residue that is evolutionarily conserved among IkappaBzeta and the related nuclear IkappaB proteins Bcl-3 and IkappaBNS Threonine substitution for Asp-451 abrogates direct association with the kappaB-site-binding protein p50, complex formation with the Lcn2 promoter DNA, and activation of Lcn2 transcription.	Aspartic Acid	66-69	lipocalin 2	Homo sapiens	393-397
27489104-5	2016	Both termini of the ANK domain in Bcl-3 and IkappaBNS function in a manner similar to that of IkappaBzeta to interact with promoter DNA, indicating a common mechanism in which the nuclear IkappaBs form a regulatory complex with NF-kappaB and promoter DNA via the invariant aspartate in ANK1 and the conserved basic residues in ANK7.	Aspartic Acid	273-282	BCL3 transcription coactivator	Homo sapiens	34-39
27489104-5	2016	Both termini of the ANK domain in Bcl-3 and IkappaBNS function in a manner similar to that of IkappaBzeta to interact with promoter DNA, indicating a common mechanism in which the nuclear IkappaBs form a regulatory complex with NF-kappaB and promoter DNA via the invariant aspartate in ANK1 and the conserved basic residues in ANK7.	Aspartic Acid	273-282	NFKB inhibitor delta	Homo sapiens	44-53
27461959-1	2016	Cytochrome P450 reductase (CPR) contains a loop within the active site (comprising Asp(634), Ala(635), Arg(636) and Asn(637); human CPR numbering) that relocates upon NADPH binding.	Aspartic Acid	83-86	cytochrome p450 oxidoreductase	Homo sapiens	0-25
27461959-1	2016	Cytochrome P450 reductase (CPR) contains a loop within the active site (comprising Asp(634), Ala(635), Arg(636) and Asn(637); human CPR numbering) that relocates upon NADPH binding.	Aspartic Acid	83-86	cytochrome p450 oxidoreductase	Homo sapiens	27-30
27399344-6	2016	According to pathway analysis by metabolites identified and correlation network construction by Pearson"s correlation coefficency matrix, alanine, aspartate and glutamate metabolism and glycerolipid metabolism were recognized as the most influenced metabolic pathways associated with CCl4 injury.	Aspartic Acid	147-156	C-C motif chemokine ligand 4	Rattus norvegicus	284-288
27622551-8	2016	Also, strong positive correlations (r &gt; 0.6) were shown between Asp/(Cr+Ch) and CD4 counts in the FG and BG.	Aspartic Acid	67-70	CD4 molecule	Homo sapiens	83-86
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Aspartic Acid	21-24	beta-secretase 1	Bos taurus	0-5
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Aspartic Acid	31-34	beta-secretase 1	Bos taurus	0-5
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Aspartic Acid	31-34	beta-secretase 1	Bos taurus	0-5
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Aspartic Acid	31-34	beta-secretase 1	Bos taurus	0-5
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Aspartic Acid	31-34	beta-secretase 1	Bos taurus	0-5
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Aspartic Acid	31-34	beta-secretase 1	Bos taurus	0-5
27399344-7	2016	As a result, notably, deviations of metabolites 1, 3, 4, 7 and 9 in the process of CCl4-induced acute liver injury were improved by CS treatment, which suggested that CS mediated synergistically abnormalities of the metabolic pathways, composed of alanine, aspartate and glutamate metabolism and glycerolipid metabolism.	Aspartic Acid	257-266	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
27451395-7	2016	Release of active SBT3 from the autoinhibited complex relied on a pH-dependent cleavage of the propeptide at Asn-38 and Asp-54.	Aspartic Acid	120-123	subtilisin-like protease	Solanum lycopersicum	18-22
27453555-7	2016	Gln- and Asp-150-substituted versions of ACO further confirmed the structural/functional requirement for a Glu side chain at this position, which is homologous to Glu-148 in RPE65, a site in which substitution to Asp has been associated with loss of enzymatic function in Leber congenital amaurosis.	Aspartic Acid	213-216	retinoid isomerohydrolase RPE65	Homo sapiens	174-179
27591355-4	2016	However, ECM over PCP mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally).	Aspartic Acid	107-110	decapentaplegic	Drosophila melanogaster	93-96
27533248-2	2016	P45 is a hybrid peptide composed of an Arg-Gly-Asp motif linked to the human matrilin-1 C-terminal domain by a serine linker.	Aspartic Acid	47-50	nuclear factor, erythroid 2	Homo sapiens	0-3
27591355-2	2016	Dpp and FGF signaling in the ASP was dependent on components of the planar cell polarity (PCP) system in the disc, and neither Dpp- nor FGF-receiving cytonemes extended over mutant disc cells that lacked them.	Aspartic Acid	29-32	decapentaplegic	Drosophila melanogaster	0-3
27591355-2	2016	Dpp and FGF signaling in the ASP was dependent on components of the planar cell polarity (PCP) system in the disc, and neither Dpp- nor FGF-receiving cytonemes extended over mutant disc cells that lacked them.	Aspartic Acid	29-32	branchless	Drosophila melanogaster	8-11
27591355-4	2016	However, ECM over PCP mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally).	Aspartic Acid	107-110	division abnormally delayed	Drosophila melanogaster	138-143
27591355-4	2016	However, ECM over PCP mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally).	Aspartic Acid	107-110	division abnormally delayed	Drosophila melanogaster	138-143
27537339-0	2016	Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells.	Aspartic Acid	31-34	prion protein	Mus musculus	8-11
27537339-3	2016	Field studies identified scrapie-protective caprine PrP variants, harboring specific single amino acid changes (Met-142, Arg-143, Asp-146, Ser-146, His-154, Gln-211 and Lys-222).	Aspartic Acid	130-133	prion protein	Mus musculus	52-55
27591355-4	2016	However, ECM over PCP mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally).	Aspartic Acid	107-110	division abnormally delayed	Drosophila melanogaster	138-143
27179641-5	2016	Mutagenesis showed that asparagine-N200 and aspartate-D201 inside transmembrane5 (TM5), and lysine-K355 inside TM10 are critical for AtCHX17 activity.	Aspartic Acid	44-53	cation/H+ exchanger 17	Arabidopsis thaliana	133-140
27440715-9	2016	Pretreatment with the cystathionine-gamma-lyase inhibitor d/l-propargylglycine (PAG) decreased hypoxic inhibition of sodium transport by H441 monolayers, whereas inhibition of cystathionine-beta-synthase (with aminooxy-acetic acid; AOAA) or 3-mercaptopyruvate sulfurtransferase (with aspartate) had no effect.	Aspartic Acid	284-293	cystathionine gamma-lyase	Homo sapiens	22-47
27590064-4	2016	ARC1 contains four domains as follows: leucine zipper (Leu(116)-Leu(137)), coiled-coil domain (Thr(210)-Val(236)), U-box (Asp(282)-Trp(347)) motif, and ARM (Ala(415)-Thr(611)) domain.	Aspartic Acid	122-125	U-box domain-containing protein 17-like	Brassica oleracea	0-4
26853542-5	2016	During apoptosis, caspases cleave K18 and K19 at conserved aspartates (human K18/K19: (235) Val-Glu-Val-Asp( ) ) and K18 at a unique aspartate (human K18: (394) Asp-Ala-Leu-Asp( ) ), with the latter exposed epitope becoming recognized by the M30 antibody in blood and tissues.	Aspartic Acid	59-68	keratin 18	Homo sapiens	34-37
26853542-5	2016	During apoptosis, caspases cleave K18 and K19 at conserved aspartates (human K18/K19: (235) Val-Glu-Val-Asp( ) ) and K18 at a unique aspartate (human K18: (394) Asp-Ala-Leu-Asp( ) ), with the latter exposed epitope becoming recognized by the M30 antibody in blood and tissues.	Aspartic Acid	59-68	keratin 19	Homo sapiens	42-45
26853542-5	2016	During apoptosis, caspases cleave K18 and K19 at conserved aspartates (human K18/K19: (235) Val-Glu-Val-Asp( ) ) and K18 at a unique aspartate (human K18: (394) Asp-Ala-Leu-Asp( ) ), with the latter exposed epitope becoming recognized by the M30 antibody in blood and tissues.	Aspartic Acid	59-69	keratin 18	Homo sapiens	34-37
26853542-5	2016	During apoptosis, caspases cleave K18 and K19 at conserved aspartates (human K18/K19: (235) Val-Glu-Val-Asp( ) ) and K18 at a unique aspartate (human K18: (394) Asp-Ala-Leu-Asp( ) ), with the latter exposed epitope becoming recognized by the M30 antibody in blood and tissues.	Aspartic Acid	59-68	keratin 18	Homo sapiens	77-80
26853542-5	2016	During apoptosis, caspases cleave K18 and K19 at conserved aspartates (human K18/K19: (235) Val-Glu-Val-Asp( ) ) and K18 at a unique aspartate (human K18: (394) Asp-Ala-Leu-Asp( ) ), with the latter exposed epitope becoming recognized by the M30 antibody in blood and tissues.	Aspartic Acid	59-69	keratin 19	Homo sapiens	42-45
26853542-5	2016	During apoptosis, caspases cleave K18 and K19 at conserved aspartates (human K18/K19: (235) Val-Glu-Val-Asp( ) ) and K18 at a unique aspartate (human K18: (394) Asp-Ala-Leu-Asp( ) ), with the latter exposed epitope becoming recognized by the M30 antibody in blood and tissues.	Aspartic Acid	59-68	keratin 18	Homo sapiens	77-80
26853542-5	2016	During apoptosis, caspases cleave K18 and K19 at conserved aspartates (human K18/K19: (235) Val-Glu-Val-Asp( ) ) and K18 at a unique aspartate (human K18: (394) Asp-Ala-Leu-Asp( ) ), with the latter exposed epitope becoming recognized by the M30 antibody in blood and tissues.	Aspartic Acid	59-68	keratin 18	Homo sapiens	77-80
27456523-10	2016	In H9c2 cells, mitochondrial Akt phosphorylation by insulin-like growth factor-1 was attenuated by malate-aspartate shuttle inhibition.	Aspartic Acid	106-115	AKT serine/threonine kinase 1	Rattus norvegicus	29-32
27525439-6	2016	Specifically, we mutated the human mHTT gene within a BAC to express either an aspartic acid or an alanine at position 421, mimicking tonic phosphorylation (mHTT-S421D mice) or preventing phosphorylation (mHTT-S421A mice), respectively.	Aspartic Acid	79-92	huntingtin	Mus musculus	35-39
27456523-10	2016	In H9c2 cells, mitochondrial Akt phosphorylation by insulin-like growth factor-1 was attenuated by malate-aspartate shuttle inhibition.	Aspartic Acid	106-115	insulin-like growth factor 1	Rattus norvegicus	52-80
27456523-11	2016	In conclusion, the results suggest that a CERA prevents CKD-induced susceptibility of the myocardium to ischemia/reperfusion injury by restoration of Akt-mediated signaling possibly via normalized malate-aspartate shuttle flux.	Aspartic Acid	204-213	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
27466182-1	2016	SHOC2 is a scaffold protein composed almost entirely by leucine-rich repeats (LRRs) and having an N-terminal region enriched in alternating lysine and glutamate/aspartate residues (KEKE motifs).	Aspartic Acid	161-170	SHOC2 leucine rich repeat scaffold protein	Homo sapiens	0-5
27381982-10	2016	Conversely, the corresponding mutations to aspartic acid in SYK reduced pY525/526 phosphorylation.	Aspartic Acid	43-56	spleen associated tyrosine kinase	Homo sapiens	60-63
27548520-6	2016	In vitro, GLS1 inhibition blocked aspartate production and reprogrammed cellular proliferation pathways, while application of aspartate restored proliferation.	Aspartic Acid	34-43	glutaminase	Homo sapiens	10-14
27581177-3	2016	Permeability data showed a significant improvement in insulin permeation especially for 10 mug/mL of lysine (p &lt; 0.05) and 10 mug/mL histidine (p &lt; 0.001), 100 mug/mL of glutamic acid (p &lt; 0.05) and 200 mug/mL of glutamic acid and aspartic acid (p &lt; 0.001) without affecting cell integrity; in contrast to sodium deoxycholate which enhanced insulin permeability but was toxic to the cells.	Aspartic Acid	240-253	insulin	Homo sapiens	54-61
27434585-9	2016	Furthermore, TetOn-HGF/hUCB-MSCs encapsulated by arginine-glycine-aspartic acid (RGD)-alginate microgel induced to express HGF improved in vivo angiogenesis in a mouse hindlimb ischemia model.	Aspartic Acid	66-79	hepatocyte growth factor	Homo sapiens	19-22
27434585-9	2016	Furthermore, TetOn-HGF/hUCB-MSCs encapsulated by arginine-glycine-aspartic acid (RGD)-alginate microgel induced to express HGF improved in vivo angiogenesis in a mouse hindlimb ischemia model.	Aspartic Acid	66-79	hepatocyte growth factor	Mus musculus	123-126
27458983-0	2016	Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.	Aspartic Acid	0-9	C-X-C motif chemokine receptor 4	Homo sapiens	16-21
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Aspartic Acid	185-188	POU class 5 homeobox 1	Homo sapiens	44-48
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Aspartic Acid	185-188	POU class 5 homeobox 1	Homo sapiens	107-111
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Aspartic Acid	185-188	POU class 5 homeobox 1	Homo sapiens	107-111
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Aspartic Acid	185-188	SRY-box transcription factor 2	Homo sapiens	180-184
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Aspartic Acid	185-188	POU class 5 homeobox 1	Homo sapiens	107-111
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Aspartic Acid	185-188	SRY-box transcription factor 2	Homo sapiens	222-226
27369080-3	2016	Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.	Aspartic Acid	137-140	POU class 5 homeobox 1	Homo sapiens	165-169
27325695-5	2016	Point mutations identified two amino acids (Lys-98 and Asp-100 in LRRC8A and equivalent residues in LRRC8C and -E), which upon charge reversal strongly altered the kinetics and voltage dependence of inactivation.	Aspartic Acid	55-58	leucine rich repeat containing 8 VRAC subunit A	Homo sapiens	66-72
27369080-3	2016	Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.	Aspartic Acid	137-140	SRY-box transcription factor 2	Homo sapiens	170-174
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Aspartic Acid	179-182	neural cell adhesion molecule 1	Homo sapiens	58-62
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Aspartic Acid	179-182	zinc finger DHHC-type palmitoyltransferase 3	Homo sapiens	216-222
28348873-3	2016	Mutational analysis of the NS1 gene indicated that p23 was generated by a novel cleavage event within the linker domain between an aspartic acid and proline at amino acid residues at positions 92 and 93 respectively (DP92-93), and that p23 contained the first 92 amino acids of the NS1 protein.	Aspartic Acid	131-144	influenza virus NS1A binding protein	Homo sapiens	27-30
28348873-3	2016	Mutational analysis of the NS1 gene indicated that p23 was generated by a novel cleavage event within the linker domain between an aspartic acid and proline at amino acid residues at positions 92 and 93 respectively (DP92-93), and that p23 contained the first 92 amino acids of the NS1 protein.	Aspartic Acid	131-144	prostaglandin E synthase 3	Homo sapiens	51-54
27353281-0	2016	A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.	Aspartic Acid	35-44	relaxin 3	Homo sapiens	80-89
27353281-0	2016	A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.	Aspartic Acid	35-44	relaxin family peptide receptor 3	Homo sapiens	99-104
27353281-3	2016	For most of the A-class GPCRs, a highly conserved negatively charged Asp residue (Asp(2.50) using Ballesteros-Weinstein numbering and Asp128 in human RXFP3) is present at the middle of TMD2.	Aspartic Acid	69-72	relaxin family peptide receptor 3	Homo sapiens	150-155
27353281-3	2016	For most of the A-class GPCRs, a highly conserved negatively charged Asp residue (Asp(2.50) using Ballesteros-Weinstein numbering and Asp128 in human RXFP3) is present at the middle of TMD2.	Aspartic Acid	82-85	relaxin family peptide receptor 3	Homo sapiens	150-155
27325695-5	2016	Point mutations identified two amino acids (Lys-98 and Asp-100 in LRRC8A and equivalent residues in LRRC8C and -E), which upon charge reversal strongly altered the kinetics and voltage dependence of inactivation.	Aspartic Acid	55-58	leucine rich repeat containing 8 VRAC subunit C	Homo sapiens	100-113
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Aspartic Acid	179-182	zinc finger DHHC-type palmitoyltransferase 7	Homo sapiens	227-233
27247265-3	2016	Previous in vitro studies revealed that palmitoylation of NCAM is required for fibroblast growth factor 2 (FGF2)-stimulated neurite outgrowth and identified the zinc finger DHHC (Asp-His-His-Cys)-containing proteins ZDHHC3 and ZDHHC7 as specific NCAM-palmitoylating enzymes.	Aspartic Acid	179-182	neural cell adhesion molecule 1	Homo sapiens	246-250
27159574-6	2016	We also show that RGG-boxes present within reiterated YGGDRGG repeats that are unique to TAF15, are defective for repression due to the conserved Asp residue.	Aspartic Acid	146-149	TATA-box binding protein associated factor 15	Homo sapiens	89-94
27409832-8	2016	Besides other investigations, large scale analysis of aspartic acid repeat polymorphism will be needed for clarification of the asporin dual role in progression of breast cancer.	Aspartic Acid	54-67	asporin	Homo sapiens	128-135
27519525-5	2016	A common modification of MBP was racemization of Asp and this was significantly greater in MS patients.	Aspartic Acid	49-52	myelin basic protein	Homo sapiens	25-28
27519525-6	2016	In long-lived proteins, L-Asp and L-Asn can racemize to three other isomers, D-isoAsp, L-isoAsp and D-Asp and this is significant because isoAsp formation in peptides renders them immunogenic.Proteomic analysis revealed widespread modifications of MBP with two surface regions that are altered in MS.	Aspartic Acid	24-29	myelin basic protein	Homo sapiens	248-251
27208619-0	2016	Single exposure to cocaine impairs aspartate uptake in the pre-frontal cortex via dopamine D1-receptor dependent mechanisms.	Aspartic Acid	35-44	dopamine receptor D1	Homo sapiens	82-102
26983943-3	2016	However, inconsistent effects of this mutation have been reported: positive effects of PYK defect in mutants having phosphoenolpyruvate carboxylase (PEPC) desensitized to feedback inhibition by aspartic acid, while negative effects in simple PYK gene (pyk) knockout mutants.	Aspartic Acid	194-207	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	87-90
27380309-9	2016	We suggest that the presence of Asn or Asp is the essential feature that defines and establishes cation selectivity in dicot HKT1-type transporters.	Aspartic Acid	39-42	high-affinity K+ transporter 1	Arabidopsis thaliana	125-129
27060251-3	2016	In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23).	Aspartic Acid	121-130	aggrecan	Mus musculus	219-223
27060251-3	2016	In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23).	Aspartic Acid	121-130	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	224-232
27060251-3	2016	In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23).	Aspartic Acid	121-130	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	Mus musculus	346-353
27060251-3	2016	In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23).	Aspartic Acid	121-130	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	Mus musculus	354-362
27060251-3	2016	In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23).	Aspartic Acid	183-192	aggrecan	Mus musculus	219-223
27060251-3	2016	In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23).	Aspartic Acid	183-192	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	224-232
27060251-3	2016	In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23).	Aspartic Acid	183-192	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	Mus musculus	346-353
27060251-3	2016	In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23).	Aspartic Acid	183-192	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	Mus musculus	354-362
26300286-6	2016	From the QSAR properties, amino acids such as asparagine and aspartic acids are the major reactive sites in the Zif268 protein.	Aspartic Acid	61-75	early growth response 1	Homo sapiens	112-118
27486797-5	2016	In this study, using the nuclear magnetic resonance technique, our data suggested that the ETR1-RD is monomeric in solution and the rigid structure of the RD prevents the conserved aspartate residue phosphorylation.	Aspartic Acid	181-190	Signal transduction histidine kinase, hybrid-type, ethylene sensor	Arabidopsis thaliana	91-95
27292613-4	2016	METHODS: Doxorubicin was coupled with the triblock polymeric material cell-penetrating TAT-PEG-poly(aspartic acid).	Aspartic Acid	100-113	tyrosine aminotransferase	Homo sapiens	87-90
27345715-1	2016	The arginylation branch of the N-end rule pathway is a ubiquitin-mediated proteolytic system in which post-translational conjugation of Arg by ATE1-encoded Arg-tRNA-protein transferase to N-terminal Asp, Glu, or oxidized Cys residues generates essential degradation signals.	Aspartic Acid	199-202	arginyltransferase 1	Mus musculus	143-147
26983943-3	2016	However, inconsistent effects of this mutation have been reported: positive effects of PYK defect in mutants having phosphoenolpyruvate carboxylase (PEPC) desensitized to feedback inhibition by aspartic acid, while negative effects in simple PYK gene (pyk) knockout mutants.	Aspartic Acid	194-207	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	149-153
27044663-3	2016	We report that internalization of GLT-1 from the cell surface is accelerated by transportable substrates like glutamate or aspartate, as well as by the transportable inhibitor L-trans-2,4-PDC, but not by the non-substrate inhibitor WAY 213613 in primary mixed cultures and in transiently transfected HEK293 cells.	Aspartic Acid	123-132	solute carrier family 1 member 2	Homo sapiens	34-39
26830332-7	2016	Moreover, we have identified an aspartic acid residue at which non-T cell activation linker is cleaved, which similar to linker for activation of T cells, this aspartic acid residue is located close to tyrosine and serine residues, suggesting an interdependence of phosphorylation and proteolytic cleavage.	Aspartic Acid	32-45	linker for activation of T cells family member 2	Homo sapiens	63-91
26830332-7	2016	Moreover, we have identified an aspartic acid residue at which non-T cell activation linker is cleaved, which similar to linker for activation of T cells, this aspartic acid residue is located close to tyrosine and serine residues, suggesting an interdependence of phosphorylation and proteolytic cleavage.	Aspartic Acid	160-173	linker for activation of T cells family member 2	Homo sapiens	63-91
27178732-6	2016	A decrease of ASP+ uptake was observed in OCT2-HEK, MATE1-HEK and MATE2K-HEK cell lines after addition of pazopanib at increasing concentrations.	Aspartic Acid	14-18	POU class 2 homeobox 2	Homo sapiens	42-46
27178732-6	2016	A decrease of ASP+ uptake was observed in OCT2-HEK, MATE1-HEK and MATE2K-HEK cell lines after addition of pazopanib at increasing concentrations.	Aspartic Acid	14-18	solute carrier family 47 member 1	Homo sapiens	52-57
27178732-6	2016	A decrease of ASP+ uptake was observed in OCT2-HEK, MATE1-HEK and MATE2K-HEK cell lines after addition of pazopanib at increasing concentrations.	Aspartic Acid	14-18	solute carrier family 47 member 2	Homo sapiens	66-72
27399771-5	2016	The primary structure of N. nomurai CTRL-1 includes a leader peptide and a highly conserved catalytic triad of His(69), Asp(117), and Ser(216).	Aspartic Acid	120-123	chymotrypsin like	Homo sapiens	36-40
27307044-7	2016	In SLC30A10, the corresponding residues are Asn-43 and Asp-47 in the second and His-244 and Asp-248 in the fifth transmembrane segments.	Aspartic Acid	55-58	solute carrier family 30 member 10	Homo sapiens	3-11
27307044-7	2016	In SLC30A10, the corresponding residues are Asn-43 and Asp-47 in the second and His-244 and Asp-248 in the fifth transmembrane segments.	Aspartic Acid	92-95	solute carrier family 30 member 10	Homo sapiens	3-11
27428327-6	2016	Ala/Asp mutations reveal that the CK2 and MAPK sites ensure that M8 repression of Ato and the R8 fate occurs in a timely manner and at a specific stage (stage-2/3) of the morphogenetic furrow (MF).	Aspartic Acid	4-7	Casein kinase II beta2 subunit	Drosophila melanogaster	34-37
27428327-6	2016	Ala/Asp mutations reveal that the CK2 and MAPK sites ensure that M8 repression of Ato and the R8 fate occurs in a timely manner and at a specific stage (stage-2/3) of the morphogenetic furrow (MF).	Aspartic Acid	4-7	rolled	Drosophila melanogaster	42-46
27428327-6	2016	Ala/Asp mutations reveal that the CK2 and MAPK sites ensure that M8 repression of Ato and the R8 fate occurs in a timely manner and at a specific stage (stage-2/3) of the morphogenetic furrow (MF).	Aspartic Acid	4-7	atonal	Drosophila melanogaster	82-85
27428327-8	2016	Accordingly, variants with a phosphomimetic Asp at the MAPK site exhibit earlier (inappropriate) activity against Ato even at stage-1 of the MF, where a positive feedback-loop is necessary to raise Ato levels to a threshold sufficient for the R8 fate.	Aspartic Acid	44-47	rolled	Drosophila melanogaster	55-59
27428327-8	2016	Accordingly, variants with a phosphomimetic Asp at the MAPK site exhibit earlier (inappropriate) activity against Ato even at stage-1 of the MF, where a positive feedback-loop is necessary to raise Ato levels to a threshold sufficient for the R8 fate.	Aspartic Acid	44-47	atonal	Drosophila melanogaster	114-117
27428327-8	2016	Accordingly, variants with a phosphomimetic Asp at the MAPK site exhibit earlier (inappropriate) activity against Ato even at stage-1 of the MF, where a positive feedback-loop is necessary to raise Ato levels to a threshold sufficient for the R8 fate.	Aspartic Acid	44-47	atonal	Drosophila melanogaster	198-201
27288788-3	2016	The physiological role of ASPA is to hydrolyse N-acetyl-l-aspartic acid (NAA), producing l-aspartic acid and acetate; as a result, its deficiency leads to abnormally high central nervous system NAA levels.	Aspartic Acid	56-71	aspartoacylase	Homo sapiens	26-30
27426034-4	2016	The phenomenon could be mimicked by either transfecting a mutant form of ANXA1 with its serine 27 residue converted to aspartic acid, S27D, or by using the PKC agonist, phorbol 12-myristate 13-acetate (PMA) in these microglial cells.	Aspartic Acid	119-132	annexin A1	Mus musculus	73-78
27134080-4	2016	Interestingly, CatSper conserves four aspartic acids (DDDD) as the negatively charged residues in this motif while high voltage-activated CaVs have four glutamic acids (EEEE) and low voltage-activated CaVs possess two glutamic acids and two aspartic acids (EEDD).	Aspartic Acid	38-52	cation channel sperm associated 1	Homo sapiens	15-22
27134080-4	2016	Interestingly, CatSper conserves four aspartic acids (DDDD) as the negatively charged residues in this motif while high voltage-activated CaVs have four glutamic acids (EEEE) and low voltage-activated CaVs possess two glutamic acids and two aspartic acids (EEDD).	Aspartic Acid	38-52	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	54-58
27134080-4	2016	Interestingly, CatSper conserves four aspartic acids (DDDD) as the negatively charged residues in this motif while high voltage-activated CaVs have four glutamic acids (EEEE) and low voltage-activated CaVs possess two glutamic acids and two aspartic acids (EEDD).	Aspartic Acid	241-255	cation channel sperm associated 1	Homo sapiens	15-22
27134080-4	2016	Interestingly, CatSper conserves four aspartic acids (DDDD) as the negatively charged residues in this motif while high voltage-activated CaVs have four glutamic acids (EEEE) and low voltage-activated CaVs possess two glutamic acids and two aspartic acids (EEDD).	Aspartic Acid	241-255	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	54-58
27208276-8	2016	In addition, mutagenesis experiments showed that the in vivo function and in vitro catalytic activity of XXT5 require the aspartate-serine-aspartate motif.	Aspartic Acid	122-131	xyloglucan xylosyltransferase 5	Arabidopsis thaliana	105-109
27474865-2	2016	There are two catalytic aspartates (ASP32 and ASP228) in the active domain of BACE1.	Aspartic Acid	24-34	beta-secretase 1	Homo sapiens	78-83
27122014-3	2016	Using homozygosity mapping followed by whole exome sequencing, we identified a homozygous c. 281C&gt;A mutation in the APOA1BP gene resulting in substitution of a highly conserved alanine residue with aspartic acid (p.Ala94Asp).	Aspartic Acid	201-214	NAD(P)HX epimerase	Homo sapiens	119-126
27208276-8	2016	In addition, mutagenesis experiments showed that the in vivo function and in vitro catalytic activity of XXT5 require the aspartate-serine-aspartate motif.	Aspartic Acid	139-148	xyloglucan xylosyltransferase 5	Arabidopsis thaliana	105-109
27208305-4	2016	Amino-acid sequence comparisons indicated differences between TsHKT1;2 and most other published HKT1 sequences with respect to an Asp residue (D207) in the second pore-loop domain.	Aspartic Acid	130-133	high-affinity K+ transporter 1	Arabidopsis thaliana	64-68
27208305-9	2016	Thus, the introduction of Asp, replacing Asn, in HKT1-type transporters established altered cation selectivity and uptake dynamics.	Aspartic Acid	26-29	high-affinity K+ transporter 1	Arabidopsis thaliana	49-53
27191381-3	2016	Compared with the self-assembled catalytic nanofibers (SA-H), which contain only the catalytic histidine residue, the highest activity of CoA-HSD occurs when histidine, serine, and aspartate residues are at a ratio of 40:1:1.	Aspartic Acid	181-190	acyl-CoA synthetase medium chain family member 3	Homo sapiens	55-59
27179783-1	2016	Cytosolic malate dehydrogenase (malate dehydrogenase 1, MDH1) plays pivotal roles in the malate/aspartate shuttle that might modulate metabolism between the cytosol and mitochondria.	Aspartic Acid	96-105	malate dehydrogenase 1	Homo sapiens	0-30
27179783-1	2016	Cytosolic malate dehydrogenase (malate dehydrogenase 1, MDH1) plays pivotal roles in the malate/aspartate shuttle that might modulate metabolism between the cytosol and mitochondria.	Aspartic Acid	96-105	malate dehydrogenase 1	Homo sapiens	32-54
27179783-1	2016	Cytosolic malate dehydrogenase (malate dehydrogenase 1, MDH1) plays pivotal roles in the malate/aspartate shuttle that might modulate metabolism between the cytosol and mitochondria.	Aspartic Acid	96-105	malate dehydrogenase 1	Homo sapiens	56-60
27323149-5	2016	There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28).	Aspartic Acid	57-60	ERCC excision repair 5, endonuclease	Homo sapiens	48-51
27323149-5	2016	There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28).	Aspartic Acid	109-112	ERCC excision repair 5, endonuclease	Homo sapiens	48-51
27323149-5	2016	There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28).	Aspartic Acid	109-112	ERCC excision repair 5, endonuclease	Homo sapiens	48-51
27323149-5	2016	There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28).	Aspartic Acid	109-112	ERCC excision repair 5, endonuclease	Homo sapiens	48-51
27323149-5	2016	There was a significant association between the XPG gene Asp1104His polymorphism and lung cancer (His/His vs Asp/Asp: OR = 1.24, 95%CI = 1.04-1.48; Asp/His vs Asp/Asp: OR = 1.17, 95%CI = 1.03-1.34; the dominant model: OR = 1.18, 95%CI = 1.04-1.33; the recessive model: OR = 1.10, 95%CI = 0.94-1.28).	Aspartic Acid	109-112	ERCC excision repair 5, endonuclease	Homo sapiens	48-51
27147579-9	2016	When Ser985 of c-Met was mutated to Aspartic acid for mimicking phosphorylation of this site, HGF-induced activation of c-Met was prevented.	Aspartic Acid	36-49	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	15-20
27233115-3	2016	In particular, both aspartate residues that occupy the positions of the chromophore Schiff base proton acceptor and donor, a hallmark of rhodopsin proton pumps, are conserved in these cryptophyte proteins.	Aspartic Acid	20-29	rhodopsin	Homo sapiens	137-146
27147579-9	2016	When Ser985 of c-Met was mutated to Aspartic acid for mimicking phosphorylation of this site, HGF-induced activation of c-Met was prevented.	Aspartic Acid	36-49	hepatocyte growth factor	Homo sapiens	94-97
27147579-9	2016	When Ser985 of c-Met was mutated to Aspartic acid for mimicking phosphorylation of this site, HGF-induced activation of c-Met was prevented.	Aspartic Acid	36-49	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	120-125
27121695-1	2016	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (DDX20), a member of the DEAD box protein family, encodes an RNA helicase.	Aspartic Acid	6-9	DEAD-box helicase 20	Homo sapiens	43-48
26797702-1	2016	Aspartoacylase (ASPA) is an abundant enzyme in the brain, which catalyzes the conversion of N-acetylaspartate into acetate and aspartate, deficiency in its activity leads to degeneration of the white matter of the brain and is a recognized cause of Canavan disease (CD), which affect children.	Aspartic Acid	100-109	aspartoacylase	Homo sapiens	0-14
26797702-1	2016	Aspartoacylase (ASPA) is an abundant enzyme in the brain, which catalyzes the conversion of N-acetylaspartate into acetate and aspartate, deficiency in its activity leads to degeneration of the white matter of the brain and is a recognized cause of Canavan disease (CD), which affect children.	Aspartic Acid	100-109	aspartoacylase	Homo sapiens	16-20
27109140-7	2016	Furthermore overexpression of DJ-1, involved in ROS scavenging, in which glutamic acid 18 (E18) is mutated to either to aspartic acid (D) or glutamine (Q) resulted in a significant increase in cell death under OS in the case of E18D mutation, whereas E18Q mutation did not impact significantly the cell response to OS, revealing the importance of the acidic group for the ROS scavenging activity of the DJ-1 protein more than the nature of the amino acid itself.	Aspartic Acid	120-133	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	30-34
27035336-1	2016	Recombinant anti-epidermal growth factor receptor-internalizing arginine-glycine-aspartic acid (anti-EGFR single-domain antibody fused with iRGD peptide) protein efficiently targets the EGFR extracellular domain and integrin alphavbeta/beta5, and shows a high penetration into cells.	Aspartic Acid	81-94	epidermal growth factor receptor	Homo sapiens	101-105
27035336-1	2016	Recombinant anti-epidermal growth factor receptor-internalizing arginine-glycine-aspartic acid (anti-EGFR single-domain antibody fused with iRGD peptide) protein efficiently targets the EGFR extracellular domain and integrin alphavbeta/beta5, and shows a high penetration into cells.	Aspartic Acid	81-94	epidermal growth factor receptor	Homo sapiens	186-190
27109476-4	2016	The structure confirm that MES16 is a member of the alpha/beta-hydrolase superfamily with Ser-87, His-239, and Asp-211 as the catalytic triad.	Aspartic Acid	111-114	methyl esterase 16	Arabidopsis thaliana	27-32
32263270-5	2016	For example, aspartate (Asp)-functionalized NaLuF4 co-doped with Tm3+ and Gd3+ not only emitted strong UCL in the range of the biological transparent window, but also has great potential as a T1-weighted magnetic resonance (MR) imaging contrast agent.	Aspartic Acid	13-22	tropomyosin 1, alpha	Mus musculus	65-68
32263270-5	2016	For example, aspartate (Asp)-functionalized NaLuF4 co-doped with Tm3+ and Gd3+ not only emitted strong UCL in the range of the biological transparent window, but also has great potential as a T1-weighted magnetic resonance (MR) imaging contrast agent.	Aspartic Acid	24-27	tropomyosin 1, alpha	Mus musculus	65-68
27189109-6	2016	In addition, ASP markedly alleviated serum and liver lipid disorders and fatty liver via the upregulation of PPARgamma expression and the activation of adiponectin-SIRT1-AMPK signaling.	Aspartic Acid	13-16	peroxisome proliferator activated receptor gamma	Mus musculus	109-118
27189109-6	2016	In addition, ASP markedly alleviated serum and liver lipid disorders and fatty liver via the upregulation of PPARgamma expression and the activation of adiponectin-SIRT1-AMPK signaling.	Aspartic Acid	13-16	adiponectin, C1Q and collagen domain containing	Mus musculus	152-163
27189109-6	2016	In addition, ASP markedly alleviated serum and liver lipid disorders and fatty liver via the upregulation of PPARgamma expression and the activation of adiponectin-SIRT1-AMPK signaling.	Aspartic Acid	13-16	sirtuin 1	Mus musculus	164-169
27189109-8	2016	In addition, ASP reduced blood glucose levels and ameliorated insulin resistance via the regulation of related metabolic enzymes and by activating the PI3K/Akt pathway in HFD-fed mice.	Aspartic Acid	13-16	thymoma viral proto-oncogene 1	Mus musculus	156-159
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Aspartic Acid	254-257	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	33-39
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Aspartic Acid	254-257	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	109-115
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Aspartic Acid	254-257	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	109-115
27153094-7	2016	By mutating the potential cleavage sites, we identified aspartic acid (Asp/D) 130 as the ICE cut site in tIL-1beta.	Aspartic Acid	56-69	caspase 1	Homo sapiens	89-92
26969161-7	2016	Finally, because molecular modeling showed that the Asp-426 side chain in CNNM3 buries into the catalytic cavity of PRL-2, we showed that a PRL inhibitor could abrogate complex formation, resulting in a decrease in proliferation of human breast cancer cells.	Aspartic Acid	52-55	cyclin and CBS domain divalent metal cation transport mediator 3	Homo sapiens	74-79
26969161-7	2016	Finally, because molecular modeling showed that the Asp-426 side chain in CNNM3 buries into the catalytic cavity of PRL-2, we showed that a PRL inhibitor could abrogate complex formation, resulting in a decrease in proliferation of human breast cancer cells.	Aspartic Acid	52-55	protein tyrosine phosphatase 4A2	Homo sapiens	116-121
27168077-3	2016	A variety of modifications of the classical caspase-3 and caspase-7 substrate sequence Asp-Glu-Val-Asp were carried out in order to increase caspase-3 affinity and eliminate caspase-7 cross-reactivity.	Aspartic Acid	87-90	caspase 7	Homo sapiens	58-67
27168077-3	2016	A variety of modifications of the classical caspase-3 and caspase-7 substrate sequence Asp-Glu-Val-Asp were carried out in order to increase caspase-3 affinity and eliminate caspase-7 cross-reactivity.	Aspartic Acid	87-90	caspase 3	Homo sapiens	141-150
27168077-3	2016	A variety of modifications of the classical caspase-3 and caspase-7 substrate sequence Asp-Glu-Val-Asp were carried out in order to increase caspase-3 affinity and eliminate caspase-7 cross-reactivity.	Aspartic Acid	87-90	caspase 7	Homo sapiens	174-183
27152961-6	2016	The identification of a granzyme B homolog with asp-ase (cleaving after aspartic acid) specificity in a non-placental mammal provides strong indications that caspase or Bid-dependent apoptosis by a serine protease with a conserved primary specificity has been part of anti-viral immunity since early mammalian evolution.	Aspartic Acid	48-51	granzyme B	Homo sapiens	24-34
27152961-6	2016	The identification of a granzyme B homolog with asp-ase (cleaving after aspartic acid) specificity in a non-placental mammal provides strong indications that caspase or Bid-dependent apoptosis by a serine protease with a conserved primary specificity has been part of anti-viral immunity since early mammalian evolution.	Aspartic Acid	48-51	BH3 interacting domain death agonist	Homo sapiens	169-172
27152961-6	2016	The identification of a granzyme B homolog with asp-ase (cleaving after aspartic acid) specificity in a non-placental mammal provides strong indications that caspase or Bid-dependent apoptosis by a serine protease with a conserved primary specificity has been part of anti-viral immunity since early mammalian evolution.	Aspartic Acid	72-85	granzyme B	Homo sapiens	24-34
27152961-6	2016	The identification of a granzyme B homolog with asp-ase (cleaving after aspartic acid) specificity in a non-placental mammal provides strong indications that caspase or Bid-dependent apoptosis by a serine protease with a conserved primary specificity has been part of anti-viral immunity since early mammalian evolution.	Aspartic Acid	72-85	BH3 interacting domain death agonist	Homo sapiens	169-172
27148850-15	2016	Aspartate and asparagine were identified as well-connected hubs in post-ERCP serum networks of cases and were correlated with aspartate transaminase (AST) and white blood cell count levels.	Aspartic Acid	0-9	solute carrier family 17 member 5	Homo sapiens	126-148
27148850-15	2016	Aspartate and asparagine were identified as well-connected hubs in post-ERCP serum networks of cases and were correlated with aspartate transaminase (AST) and white blood cell count levels.	Aspartic Acid	0-9	solute carrier family 17 member 5	Homo sapiens	150-153
27153094-7	2016	By mutating the potential cleavage sites, we identified aspartic acid (Asp/D) 130 as the ICE cut site in tIL-1beta.	Aspartic Acid	71-74	caspase 1	Homo sapiens	89-92
27200039-4	2016	In vitro assays to compare the capacity of recombinant AtDIR1 and targeted AtDIR1-variant proteins to bind the lipophilic probe TNS (6,P-toluidinylnaphthalene-2-sulfonate) provided evidence that conserved leucine 43 and aspartic acid 39 contribute to the size of the DIR1 hydrophobic cavity and possibly hydrophobic ligand binding.	Aspartic Acid	220-233	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein	Arabidopsis thaliana	75-81
27091970-8	2016	The reduced neural response in the dACC was significantly correlated with Psi-induced changes in self-processing and decreased aspartate (Asp) content.	Aspartic Acid	127-136	Acetyl-CoA carboxylase	Drosophila melanogaster	35-39
27086848-3	2016	Following doxorubicin administration, TNBC cells acquire metabolic alteration, causing increased glutamine flux for the synthesis of aspartate which can be converted into OAA by GOT1.	Aspartic Acid	133-142	glutamic-oxaloacetic transaminase 1	Homo sapiens	178-182
27091970-8	2016	The reduced neural response in the dACC was significantly correlated with Psi-induced changes in self-processing and decreased aspartate (Asp) content.	Aspartic Acid	138-141	Acetyl-CoA carboxylase	Drosophila melanogaster	35-39
25858017-3	2016	Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine, and its expression is associated with the chemotherapy resistance and prognosis in several human cancers.	Aspartic Acid	114-127	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
25858017-3	2016	Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine, and its expression is associated with the chemotherapy resistance and prognosis in several human cancers.	Aspartic Acid	114-127	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
26325019-14	2016	Asp interacted with arginine residues of bovine serum albumin particularly ARG 194, ARG 198, and ARG 217 thereby stabilized the protein complex.	Aspartic Acid	0-3	albumin	Homo sapiens	48-61
26969488-1	2016	HLA-A*24:02:50 has one synonymous nucleotide change from HLA-A*24:02:01:01 at nucleotide 429 (codon 119 aspartic acid).	Aspartic Acid	104-117	major histocompatibility complex, class I, A	Homo sapiens	0-5
26969488-1	2016	HLA-A*24:02:50 has one synonymous nucleotide change from HLA-A*24:02:01:01 at nucleotide 429 (codon 119 aspartic acid).	Aspartic Acid	104-117	major histocompatibility complex, class I, A	Homo sapiens	57-62
27111489-2	2016	Two aspartic acid residues are present in the BACE1 catalytic region which can adopt multiple protonation states depending on the chemical nature of its inhibitors, i.e., monoprotonated, diprotonated and di-deprotonated states.	Aspartic Acid	4-17	beta-secretase 1	Homo sapiens	46-51
27126795-1	2016	Silencing of ODC also led to significantly reduced concentrations of polyamines (putrescine, spermidine and spermine), tyramine and phenolamides (caffeoylputrescine and dicaffeoylspermidine) with concomitant increases in concentrations of amino acids ornithine, arginine, aspartate, glutamate and glutamine.	Aspartic Acid	272-281	ornithine decarboxylase	Nicotiana tabacum	13-16
26865631-3	2016	Residues Arg-309 and Asp-85 (rat P2X4 numbering) are highly conserved throughout the P2X family and were involved in loss-of-function polymorphism in human P2X receptors.	Aspartic Acid	21-24	purinergic receptor P2X 4	Rattus norvegicus	33-37
26921316-0	2016	Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells.	Aspartic Acid	0-9	KRAS proto-oncogene, GTPase	Homo sapiens	83-87
27098689-1	2016	UNLABELLED: ARALAR/AGC1/Slc25a12, the aspartate-glutamate carrier from brain mitochondria, is the regulatory step in the malate-aspartate NADH shuttle, MAS.	Aspartic Acid	38-47	aggrecan	Mus musculus	19-23
27098689-1	2016	UNLABELLED: ARALAR/AGC1/Slc25a12, the aspartate-glutamate carrier from brain mitochondria, is the regulatory step in the malate-aspartate NADH shuttle, MAS.	Aspartic Acid	38-47	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	24-32
26865631-13	2016	All these findings provided new insights in understanding the contribution of the salt bridge between Asp-85 and Arg-309 and its structurally coupled beta2,3-sheet to the function of P2X receptors.	Aspartic Acid	102-105	neuronal differentiation 1	Homo sapiens	150-155
27054574-16	2016	Subsequent analysis reveals that a single amino acid substitution from aspartic acid in hAQP4 to glutamic acid in murine (m)AQP4 at position 290 prevents the recognition of hAQP4281-300 by the murine T cell receptor (TCR).	Aspartic Acid	71-84	aquaporin 4	Homo sapiens	88-93
26890358-4	2016	In this work, the unprecedented increased enzymatic activity and intracellular penetration achieved by the association of a human recombinant GLA to nanoliposomes functionalized with Arginine-Glycine-Aspartic acid (RGD) peptides is reported.	Aspartic Acid	200-213	galactosidase alpha	Homo sapiens	142-145
27054574-16	2016	Subsequent analysis reveals that a single amino acid substitution from aspartic acid in hAQP4 to glutamic acid in murine (m)AQP4 at position 290 prevents the recognition of hAQP4281-300 by the murine T cell receptor (TCR).	Aspartic Acid	71-84	aquaporin 4	Mus musculus	89-93
26972470-2	2016	The protein contains a functional PDZ domain that has been solved in complex with a phage display-derived heptapeptide: Asp-6 Ser-5 Arg-4 Ile-3 Trp-2 Trp-1 Val0 .	Aspartic Acid	120-123	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	144-149
26972470-2	2016	The protein contains a functional PDZ domain that has been solved in complex with a phage display-derived heptapeptide: Asp-6 Ser-5 Arg-4 Ile-3 Trp-2 Trp-1 Val0 .	Aspartic Acid	120-123	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	150-155
26858254-2	2016	Ate1 arginylates N-terminal Asp, Glu, or (oxidized) Cys.	Aspartic Acid	28-31	arginyltransferase 1	Mus musculus	0-4
26802312-7	2016	The main interactions are electrostatic bonds between the positively charged amino groups of aminoglycosides and Glu or Asp residues of APH.	Aspartic Acid	120-123	acylaminoacyl-peptide hydrolase	Homo sapiens	136-139
26843365-8	2016	At admission, compared with aspirin sensitive patients (ASP), patients with APR had more frequently diabetes, anterior infarction and heart failure, while AHR patients had reduced values of creatine kinase, leukocytes, heart rate and systolic blood pressure.	Aspartic Acid	56-59	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	76-79
26867578-7	2016	The general base aspartate in the PIG-L deacetylases is an alanine in GalB; replacement of the alanine with aspartate decreased the GalB catalytic efficiency for CHM by 9.5 x 10(4)-fold, and the variant enzyme did not have any detectable hydrolase activity.	Aspartic Acid	108-117	phosphatidylinositol glycan anchor biosynthesis class L	Sus scrofa	34-39
26692170-8	2016	CYB5D2 binds heme, in which aspartate (D) 86 is required.	Aspartic Acid	28-37	cytochrome b5 domain containing 2	Homo sapiens	0-6
26855417-3	2016	Compared to WT, mouse lung fibroblasts (MLG) stably transfected with a degradation resistant Rev-erbalpha (Ser(55/59) to Asp; hence referred to as SD) had 40% higher protein content, 1.5-fold higher mitochondrial area (confocal microscopy), doubled oxidative phosphorylation by high-resolution respirometry (Oroboros) and were resistant to glucose deprivation for 24h.	Aspartic Acid	121-124	nuclear receptor subfamily 1, group D, member 1	Mus musculus	93-105
26817847-4	2016	By expression in a mutant lacking all LHCSR isoforms, residues Asp(117), Glu(221), and Glu(224)were shown to be essential for LHCSR3-dependent NPQ induction inC. reinhardtii Analysis of recombinant proteins carrying the same mutations refoldedin vitrowith pigments showed that the capacity of responding to low pH by decreasing the fluorescence lifetime, present in the wild-type protein, was lost.	Aspartic Acid	63-66	uncharacterized protein	Chlamydomonas reinhardtii	126-132
26867578-7	2016	The general base aspartate in the PIG-L deacetylases is an alanine in GalB; replacement of the alanine with aspartate decreased the GalB catalytic efficiency for CHM by 9.5 x 10(4)-fold, and the variant enzyme did not have any detectable hydrolase activity.	Aspartic Acid	17-26	phosphatidylinositol glycan anchor biosynthesis class L	Sus scrofa	34-39
26899411-6	2016	The same patches are simulated for the Vpu double mutant, Vpu-DD, in which the two serines 52 and 56 are replaced by aspartic acid.	Aspartic Acid	117-130	Vpu	Human immunodeficiency virus 1	39-42
26832798-7	2016	Our data show that long-term exposure of cells to SCH772984 leads to acquired resistance, attributable to a mutation of glycine to aspartic acid (G(186D)) in the DFG motif of ERK1.	Aspartic Acid	131-144	mitogen-activated protein kinase 3	Homo sapiens	175-179
26899411-6	2016	The same patches are simulated for the Vpu double mutant, Vpu-DD, in which the two serines 52 and 56 are replaced by aspartic acid.	Aspartic Acid	117-130	Vpu	Human immunodeficiency virus 1	58-61
26548749-7	2016	The TLR2 Ins/Del genotype is associated with tumor evolution to stage (III+IV) [p = 0.003; OR: 3.00 (1.22-7.35)] and the genotypes Gly/Gly and Asp/Gly+Gly/Gly and Gly allele of TLR 4 are implicated in tumor evolution to the advanced stages.	Aspartic Acid	143-146	toll like receptor 2	Homo sapiens	4-8
25663199-2	2016	Studies investigating the possible association between ASD and polymorphism in SLC25A12, which encodes the mitochondrial aspartate/glutamate carrier, have yielded inconsistent results.	Aspartic Acid	121-130	solute carrier family 25 member 12	Homo sapiens	79-87
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Aspartic Acid	134-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
26956095-5	2016	These integrins are known to specifically interact with vitronectin and collagen-IV, respectively, through binding to an Arg-Gly-Asp (RGD) sequence.	Aspartic Acid	129-132	vitronectin	Homo sapiens	56-67
26773038-8	2016	Substitution of the surface-exposed Y1544 to aspartic acid is able to stabilize the domain in the absence of glycosylation and protect against ADAMTS13 proteolysis in both the VWF A2 domain and FLVWF.	Aspartic Acid	45-58	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	143-151
26773038-8	2016	Substitution of the surface-exposed Y1544 to aspartic acid is able to stabilize the domain in the absence of glycosylation and protect against ADAMTS13 proteolysis in both the VWF A2 domain and FLVWF.	Aspartic Acid	45-58	von Willebrand factor	Homo sapiens	176-179
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Aspartic Acid	134-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27042204-7	2016	Formation of MLL" and ML2L" species was confirmed for asparagine and aspartic acid.	Aspartic Acid	69-82	lysine methyltransferase 2A	Homo sapiens	13-16
26797122-8	2016	Here we show by site-directed mutagenesis that multiple residues within the SF region (Pro(165), Tyr(166), Ser(167), and Asp(168)) of apoA-I are critical for both LCAT binding to HDL and LCAT catalytic efficiency.	Aspartic Acid	121-124	apolipoprotein A1	Homo sapiens	134-140
27031502-3	2016	An anomaly in the active-site peptide from CSNK1A1 was observed in a tumor sample that was consistent with an altered catalytic aspartic acid.	Aspartic Acid	128-141	casein kinase 1 alpha 1	Homo sapiens	43-50
27031502-5	2016	Genomic sequencing of the colon tumor samples confirmed the presence of a missense mutation in the catalytic aspartic acid of CSNK1A1 (GAC AAC).	Aspartic Acid	109-122	casein kinase 1 alpha 1	Homo sapiens	126-133
27031502-5	2016	Genomic sequencing of the colon tumor samples confirmed the presence of a missense mutation in the catalytic aspartic acid of CSNK1A1 (GAC AAC).	Aspartic Acid	109-122	glycine-N-acyltransferase	Homo sapiens	139-142
26958941-2	2016	Here, we show that Bcl-xL oncogenic function can be uncoupled from its anti-apoptotic activity when it is regulated by the post-translational deamidation of its Asn52.Bcl-xL activity can be regulated by post-translational modifications: deamidation of Asn52 and 66 into Asp residues was reported to occur exclusively in response to DNA damage, and to cripple its anti-apoptotic activity.	Aspartic Acid	270-273	BCL2 like 1	Homo sapiens	19-25
26958941-2	2016	Here, we show that Bcl-xL oncogenic function can be uncoupled from its anti-apoptotic activity when it is regulated by the post-translational deamidation of its Asn52.Bcl-xL activity can be regulated by post-translational modifications: deamidation of Asn52 and 66 into Asp residues was reported to occur exclusively in response to DNA damage, and to cripple its anti-apoptotic activity.	Aspartic Acid	270-273	BCL2 like 1	Homo sapiens	167-173
27031502-6	2016	To our knowledge, the D163N mutation in CSNK1A1 is a newly defined mutation to the conserved, catalytic aspartic acid of a protein kinase and the first missense mutation identified using activity-based proteomics.	Aspartic Acid	104-117	casein kinase 1 alpha 1	Homo sapiens	40-47
27010854-5	2016	Since ARTD1 is cleaved at aspartate(214), we studied the impact of ARTD1 rendered uncleavable by D214N substitution (ARTD1(D214N)) on skeletal homeostasis.	Aspartic Acid	26-35	poly (ADP-ribose) polymerase family, member 1	Mus musculus	6-11
26797122-8	2016	Here we show by site-directed mutagenesis that multiple residues within the SF region (Pro(165), Tyr(166), Ser(167), and Asp(168)) of apoA-I are critical for both LCAT binding to HDL and LCAT catalytic efficiency.	Aspartic Acid	121-124	lecithin-cholesterol acyltransferase	Homo sapiens	163-167
26936955-6	2016	A conserved catalytic Asp residue is required for Gdh1"s functions in telomeric silencing and H3 clipping.	Aspartic Acid	22-25	glutamate dehydrogenase 1	Homo sapiens	50-54
27117097-6	2016	Because of the low concentration of L-aspartate (L-Asp) in the blood, AST is the only enzyme, which supply of this amino acid as a substrate for many metabolic processes, such as urea cycle or purine and pyrimidine nucleotides in the liver, synthesis of L-arginine in the kidney and purine nucleotide cycle in the brain and the skeletal muscle.	Aspartic Acid	36-47	solute carrier family 17 member 5	Homo sapiens	70-73
27117097-6	2016	Because of the low concentration of L-aspartate (L-Asp) in the blood, AST is the only enzyme, which supply of this amino acid as a substrate for many metabolic processes, such as urea cycle or purine and pyrimidine nucleotides in the liver, synthesis of L-arginine in the kidney and purine nucleotide cycle in the brain and the skeletal muscle.	Aspartic Acid	49-54	solute carrier family 17 member 5	Homo sapiens	70-73
26811873-6	2016	A metabolic pathway analysis also indicated that insulin affected the metabolism of alanine, aspartate and glutamate, as well as that of arginine and proline.	Aspartic Acid	93-102	insulin	Homo sapiens	49-56
26983869-9	2016	In univariate analyses, the following parameters significantly influenced patient survival: pre-operative aspartate (AST; p=0.013) and alanine (ALT; p=0.043) aminotransferases activity, INR (p=0.040), bilirubin concentration (p=0.045), and donor age (p=0.033).	Aspartic Acid	106-115	solute carrier family 17 member 5	Homo sapiens	117-120
26820485-0	2016	Structural and Biochemical Characterization of a Copper-Binding Mutant of the Organomercurial Lyase MerB: Insight into the Key Role of the Active Site Aspartic Acid in Hg-Carbon Bond Cleavage and Metal Binding Specificity.	Aspartic Acid	151-164	alkylmercury lyase	Escherichia coli	100-104
26367539-4	2016	We further demonstrate that marked selectivity for the second over the first bromodomain can be achieved with an indole derivative that exploits differential interaction with an aspartate/histidine conservative substitution on the BC loop of BET bromodomains.	Aspartic Acid	178-187	delta/notch like EGF repeat containing	Homo sapiens	242-245
26820485-7	2016	These results demonstrate that the active site aspartic acid is crucial for both the enzymatic activity and metal binding specificity of MerB proteins and suggest a possible functional relationship between MerB and its only known structural homologue, the copper-binding protein NosL.	Aspartic Acid	47-60	alkylmercury lyase	Escherichia coli	137-141
26820485-7	2016	These results demonstrate that the active site aspartic acid is crucial for both the enzymatic activity and metal binding specificity of MerB proteins and suggest a possible functional relationship between MerB and its only known structural homologue, the copper-binding protein NosL.	Aspartic Acid	47-60	alkylmercury lyase	Escherichia coli	206-210
26676750-5	2016	Mechanistic investigations defined aspartate 44 in ODC as critical for binding.	Aspartic Acid	35-44	ornithine decarboxylase, structural 1	Mus musculus	51-54
26848530-6	2016	Compared with estrogen receptor (ER)-negative group, ER-positive patients showed elevated alanine, aspartate and glutamate metabolism, decreased glycerolipid catabolism, and enhanced purine metabolism.	Aspartic Acid	99-108	estrogen receptor 1	Homo sapiens	53-55
26927183-2	2016	The next two amino acids incorporated would have been the other two small hydrophilic amino acids serine and aspartic acid, which occurred through the duplication of the tRNA(Gly) sequence, followed by mutation of its anticodon by single C to U transition mutations, possibly through spontaneous deamination.	Aspartic Acid	109-122	mitochondrially encoded tRNA glycine	Homo sapiens	170-179
26820485-2	2016	Two cysteines (C96 and C159; Escherichia coli MerB numbering) and an aspartic acid (D99) have been identified as the key catalytic residues, and these three residues are conserved in all but four known MerB variants, where the aspartic acid is replaced with a serine.	Aspartic Acid	227-240	alkylmercury lyase	Escherichia coli	202-206
26843956-11	2015	CONCLUSIONS: We identified the lanthanide metal ions binding sites in alpha-synuclein and found a hierarchal effect for lanthanide ions binding to alpha-synuclein, driven by the interaction with aspartic acids and glutamic acids residues.	Aspartic Acid	195-209	synuclein alpha	Homo sapiens	147-162
26694607-4	2016	TgLCAT contains a motif characteristic of serine lipases "AHSLG" and the catalytic triad consisting of serine, aspartate, and histidine (SDH) from LCAT enzymes.	Aspartic Acid	111-120	lecithin-cholesterol acyltransferase	Homo sapiens	2-6
27308634-2	2016	We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation.	Aspartic Acid	91-100	argininosuccinate synthase 1	Homo sapiens	32-36
26611529-1	2016	NGLY1/Ngly1 is a cytosolic peptide:N-glycanase, i.e. de-N-glycosylating enzyme acting on N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated peptides in which the N-glycosylated asparagine residues are converted to aspartates.	Aspartic Acid	250-260	N-glycanase 1	Homo sapiens	0-5
26611529-1	2016	NGLY1/Ngly1 is a cytosolic peptide:N-glycanase, i.e. de-N-glycosylating enzyme acting on N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated peptides in which the N-glycosylated asparagine residues are converted to aspartates.	Aspartic Acid	250-260	N-glycanase 1	Homo sapiens	6-11
26352274-7	2016	Phylogenetic analyses clearly indicated that animal SerR and AspR are not separated by their particular racemase functions and form a serine/aspartate racemase family cluster.	Aspartic Acid	141-150	serine racemase	Crassostrea gigas	52-56
27162710-4	2016	RESULTS: Twelve of the 15 patients had the fusion segment at L4-5, and the most common segment affected by ASP was L3-4.	Aspartic Acid	107-110	ribosomal protein L34	Homo sapiens	115-119
26352274-9	2016	Moreover, we propose that the triple serine loop motif at amino acid positions 150-152 may be responsible for the large aspartate racemase activity and the AspR evolution from SerR.	Aspartic Acid	120-129	serine racemase	Crassostrea gigas	176-180
26741264-6	2016	Furthermore, ASP pretreatment significantly decreased proinflammatory cytokines (TNF-alpha, IFN-gamma, IL-2 and IL-6) and alleviated oxidative stress by reducing MDA and ROS levels and by enhancing SOD activity after ConA administration in mice.	Aspartic Acid	13-16	tumor necrosis factor	Mus musculus	81-90
26741264-6	2016	Furthermore, ASP pretreatment significantly decreased proinflammatory cytokines (TNF-alpha, IFN-gamma, IL-2 and IL-6) and alleviated oxidative stress by reducing MDA and ROS levels and by enhancing SOD activity after ConA administration in mice.	Aspartic Acid	13-16	interferon gamma	Mus musculus	92-101
26741264-6	2016	Furthermore, ASP pretreatment significantly decreased proinflammatory cytokines (TNF-alpha, IFN-gamma, IL-2 and IL-6) and alleviated oxidative stress by reducing MDA and ROS levels and by enhancing SOD activity after ConA administration in mice.	Aspartic Acid	13-16	interleukin 2	Mus musculus	103-107
26741264-6	2016	Furthermore, ASP pretreatment significantly decreased proinflammatory cytokines (TNF-alpha, IFN-gamma, IL-2 and IL-6) and alleviated oxidative stress by reducing MDA and ROS levels and by enhancing SOD activity after ConA administration in mice.	Aspartic Acid	13-16	interleukin 6	Mus musculus	112-116
26741264-7	2016	Results of Western blot analysis indicated that ASP attenuated Caspase-3-dependent apoptosis by Caspase-8 and JNK-mediated pathway and inhibited the activation of IL-6/STAT3 and NF-kappaB signaling pathways in ConA-induced liver damage in mice.	Aspartic Acid	48-51	caspase 3	Mus musculus	63-72
26741264-7	2016	Results of Western blot analysis indicated that ASP attenuated Caspase-3-dependent apoptosis by Caspase-8 and JNK-mediated pathway and inhibited the activation of IL-6/STAT3 and NF-kappaB signaling pathways in ConA-induced liver damage in mice.	Aspartic Acid	48-51	caspase 8	Mus musculus	96-105
26741264-7	2016	Results of Western blot analysis indicated that ASP attenuated Caspase-3-dependent apoptosis by Caspase-8 and JNK-mediated pathway and inhibited the activation of IL-6/STAT3 and NF-kappaB signaling pathways in ConA-induced liver damage in mice.	Aspartic Acid	48-51	mitogen-activated protein kinase 8	Mus musculus	110-113
26741264-7	2016	Results of Western blot analysis indicated that ASP attenuated Caspase-3-dependent apoptosis by Caspase-8 and JNK-mediated pathway and inhibited the activation of IL-6/STAT3 and NF-kappaB signaling pathways in ConA-induced liver damage in mice.	Aspartic Acid	48-51	interleukin 6	Mus musculus	163-167
26741264-7	2016	Results of Western blot analysis indicated that ASP attenuated Caspase-3-dependent apoptosis by Caspase-8 and JNK-mediated pathway and inhibited the activation of IL-6/STAT3 and NF-kappaB signaling pathways in ConA-induced liver damage in mice.	Aspartic Acid	48-51	signal transducer and activator of transcription 3	Mus musculus	168-173
26714726-7	2016	Expressions of DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 (DDX4), deleted in azoospermia like (DAZL), transition protein 2 (TP2), proliferating cell nuclear antigen (PCNA) and 5-Bromo-20-deoxyuridine (BrdU) were assessed.	Aspartic Acid	33-36	probable ATP-dependent RNA helicase DDX4	Oryctolagus cuniculus	57-61
26189884-6	2016	D-Asp induced phosphorylation of ERK and Akt proteins, stimulated expression of PCNA and Aurora B, and enhanced mRNA synthesis and protein expression of P450 aromatase and protein expression of Estrogen Receptor beta (ERbeta).	Aspartic Acid	2-5	mitogen-activated protein kinase 1	Mus musculus	33-36
26189884-6	2016	D-Asp induced phosphorylation of ERK and Akt proteins, stimulated expression of PCNA and Aurora B, and enhanced mRNA synthesis and protein expression of P450 aromatase and protein expression of Estrogen Receptor beta (ERbeta).	Aspartic Acid	2-5	thymoma viral proto-oncogene 1	Mus musculus	41-44
26189884-6	2016	D-Asp induced phosphorylation of ERK and Akt proteins, stimulated expression of PCNA and Aurora B, and enhanced mRNA synthesis and protein expression of P450 aromatase and protein expression of Estrogen Receptor beta (ERbeta).	Aspartic Acid	2-5	proliferating cell nuclear antigen	Mus musculus	80-84
26189884-6	2016	D-Asp induced phosphorylation of ERK and Akt proteins, stimulated expression of PCNA and Aurora B, and enhanced mRNA synthesis and protein expression of P450 aromatase and protein expression of Estrogen Receptor beta (ERbeta).	Aspartic Acid	2-5	aurora kinase C	Mus musculus	89-97
26189884-6	2016	D-Asp induced phosphorylation of ERK and Akt proteins, stimulated expression of PCNA and Aurora B, and enhanced mRNA synthesis and protein expression of P450 aromatase and protein expression of Estrogen Receptor beta (ERbeta).	Aspartic Acid	2-5	estrogen receptor 2 (beta)	Mus musculus	194-216
26189884-6	2016	D-Asp induced phosphorylation of ERK and Akt proteins, stimulated expression of PCNA and Aurora B, and enhanced mRNA synthesis and protein expression of P450 aromatase and protein expression of Estrogen Receptor beta (ERbeta).	Aspartic Acid	2-5	estrogen receptor 2 (beta)	Mus musculus	218-224
26714726-7	2016	Expressions of DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 (DDX4), deleted in azoospermia like (DAZL), transition protein 2 (TP2), proliferating cell nuclear antigen (PCNA) and 5-Bromo-20-deoxyuridine (BrdU) were assessed.	Aspartic Acid	21-24	probable ATP-dependent RNA helicase DDX4	Oryctolagus cuniculus	57-61
26168906-1	2016	Phosphoenolpyruvate carboxylase (PEPC) in Corynebacterium glutamicum ATCC13032, a glutamic-acid producing actinobacterium, is subject to feedback inhibition by metabolic intermediates such as aspartic acid and 2-oxoglutaric acid, which implies the importance of PEPC in replenishing oxaloacetic acid into the TCA cycle.	Aspartic Acid	192-205	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	0-31
26168906-1	2016	Phosphoenolpyruvate carboxylase (PEPC) in Corynebacterium glutamicum ATCC13032, a glutamic-acid producing actinobacterium, is subject to feedback inhibition by metabolic intermediates such as aspartic acid and 2-oxoglutaric acid, which implies the importance of PEPC in replenishing oxaloacetic acid into the TCA cycle.	Aspartic Acid	192-205	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	33-37
26168906-1	2016	Phosphoenolpyruvate carboxylase (PEPC) in Corynebacterium glutamicum ATCC13032, a glutamic-acid producing actinobacterium, is subject to feedback inhibition by metabolic intermediates such as aspartic acid and 2-oxoglutaric acid, which implies the importance of PEPC in replenishing oxaloacetic acid into the TCA cycle.	Aspartic Acid	192-205	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	262-266
26168906-3	2016	A single amino-acid substitution in PEPC, D299N, was found to relieve the feedback control by aspartic acid, but not by 2-oxoglutaric acid.	Aspartic Acid	94-107	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	36-40
26772541-10	2016	A novel mutation (c.86A &gt; CC) was identified on exon 3 [corrected] of the APOC2 gene, which converted the Asp [corrected] codon at position 29 into Ala, followed by a termination codon (TGA).	Aspartic Acid	109-112	apolipoprotein C2	Homo sapiens	77-82
26751703-4	2016	Finally, we applied our aspartic acid building blocks to the stepwise Fmoc SPPS of teduglutide, a human GLP-2 analogue, whose synthesis is made challenging by extensive aspartimide formation.	Aspartic Acid	24-37	glucagon	Homo sapiens	104-109
26829353-3	2016	Mutation of Ser to Ala in N-terminus of GhDi19-1/-2 led to the altered subcellular localization of the two proteins, but the constitutively activated form (Ser was mutated to Asp) of GhDi19-1/-2 still showed the nuclear localization.	Aspartic Acid	175-178	protein DEHYDRATION-INDUCED 19 homolog 3-like	Gossypium hirsutum	40-51
26913389-7	2016	FIB levels decreased slower after treatment of PEG-ASP (9.49 vs 6.90) (P = 0.000) than that after treatment of L-ASP.	Aspartic Acid	111-116	fibrinogen beta chain	Homo sapiens	0-3
26913389-8	2016	When L-ASP used at interval, FIB level decreased slower than that of continuous use.	Aspartic Acid	5-10	fibrinogen beta chain	Homo sapiens	29-32
26799485-0	2016	Arg-Gly-Asp (RGD)-Modified E1A/E1B Double Mutant Adenovirus Enhances Antitumor Activity in Prostate Cancer Cells In Vitro and in Mice.	Aspartic Acid	8-11	small nucleolar RNA, H/ACA box 73a	Mus musculus	31-34
26739563-8	2016	We have reconstituted the purified AGT1-rBAT heterodimer into proteoliposomes and showed that AGT1 transports cystine, aspartate, and glutamate.	Aspartic Acid	119-128	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	Mus musculus	35-39
26739563-8	2016	We have reconstituted the purified AGT1-rBAT heterodimer into proteoliposomes and showed that AGT1 transports cystine, aspartate, and glutamate.	Aspartic Acid	119-128	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	40-44
26739563-8	2016	We have reconstituted the purified AGT1-rBAT heterodimer into proteoliposomes and showed that AGT1 transports cystine, aspartate, and glutamate.	Aspartic Acid	119-128	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	Mus musculus	94-98
26739563-10	2016	EAAC1 is proposed to take up aspartate and glutamate released into luminal fluid by AGT1 due to its countertransport so that preventing the urinary loss of aspartate and glutamate.	Aspartic Acid	29-38	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	0-5
26739563-10	2016	EAAC1 is proposed to take up aspartate and glutamate released into luminal fluid by AGT1 due to its countertransport so that preventing the urinary loss of aspartate and glutamate.	Aspartic Acid	29-38	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	Mus musculus	84-88
26739563-10	2016	EAAC1 is proposed to take up aspartate and glutamate released into luminal fluid by AGT1 due to its countertransport so that preventing the urinary loss of aspartate and glutamate.	Aspartic Acid	156-165	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	0-5
26739563-10	2016	EAAC1 is proposed to take up aspartate and glutamate released into luminal fluid by AGT1 due to its countertransport so that preventing the urinary loss of aspartate and glutamate.	Aspartic Acid	156-165	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	Mus musculus	84-88
26429295-6	2016	The model substrates of 4-[4-(dimethylamino) styryl]-N-methylpyridinium iodide (ASP(+)) and carboxy-dichlorofluorescein (CDF) for OCTN1 and MRP1, respectively, were used in the lung cells from five donors.	Aspartic Acid	80-86	solute carrier family 22 member 4	Homo sapiens	130-135
26429295-6	2016	The model substrates of 4-[4-(dimethylamino) styryl]-N-methylpyridinium iodide (ASP(+)) and carboxy-dichlorofluorescein (CDF) for OCTN1 and MRP1, respectively, were used in the lung cells from five donors.	Aspartic Acid	80-86	ATP binding cassette subfamily C member 1	Homo sapiens	140-144
26429295-7	2016	Significant correlation was found between the kinetic parameter Vmax for ASP(+) and OCTN1 protein expression in plasma membrane of tracheal, bronchial, and alveolar cells (r(2) = 0.965, 0.834, and 0.877, respectively), and between the efflux of CDF and MRP1 protein expression in plasma membrane of tracheal, bronchial, and alveolar cells (r(2) = 0.800, 0.904, and 0.790, respectively).	Aspartic Acid	73-76	solute carrier family 22 member 4	Homo sapiens	84-89
26429295-7	2016	Significant correlation was found between the kinetic parameter Vmax for ASP(+) and OCTN1 protein expression in plasma membrane of tracheal, bronchial, and alveolar cells (r(2) = 0.965, 0.834, and 0.877, respectively), and between the efflux of CDF and MRP1 protein expression in plasma membrane of tracheal, bronchial, and alveolar cells (r(2) = 0.800, 0.904, and 0.790, respectively).	Aspartic Acid	73-76	ATP binding cassette subfamily C member 1	Homo sapiens	253-257
26808997-9	2016	Many other differentially expressed genes were associated with metabolic pathways (including "Fatty acid metabolism", "Alanine, aspartate, and glutamate metabolism", and "Biosynthesis of unsaturated fatty acids") and cell signaling pathways (including "PPAR signaling pathway", "Adipocytokine signaling pathway", "TGF-beta signaling pathway", "MAPK signaling pathway", and "p53 signaling pathway").	Aspartic Acid	128-137	peroxisome proliferator activated receptor alpha	Gallus gallus	253-257
26600122-2	2016	It is believed that the interaction, of both hydrogen bonding and electrostatic nature, involves a partly protonated form of Mozobil( ), LHn(n+) and the COO(-) groups of Asp(171) and Asp(262) residues protruding from the walls of the pocket of the membrane protein CXCR4.	Aspartic Acid	170-173	C-X-C motif chemokine receptor 4	Homo sapiens	265-270
26600122-2	2016	It is believed that the interaction, of both hydrogen bonding and electrostatic nature, involves a partly protonated form of Mozobil( ), LHn(n+) and the COO(-) groups of Asp(171) and Asp(262) residues protruding from the walls of the pocket of the membrane protein CXCR4.	Aspartic Acid	183-186	C-X-C motif chemokine receptor 4	Homo sapiens	265-270
26600122-6	2016	It is finally suggested that, in the pocket of the CXCR4 membrane protein, Mozobil( ) operates as a pentammonium cation, which establishes with carboxylate groups of Asp(171) and Asp(262) strong interactions of hydrogen bonding and electrostatic nature.	Aspartic Acid	166-169	C-X-C motif chemokine receptor 4	Homo sapiens	51-56
26600122-6	2016	It is finally suggested that, in the pocket of the CXCR4 membrane protein, Mozobil( ) operates as a pentammonium cation, which establishes with carboxylate groups of Asp(171) and Asp(262) strong interactions of hydrogen bonding and electrostatic nature.	Aspartic Acid	179-182	C-X-C motif chemokine receptor 4	Homo sapiens	51-56
26446945-3	2016	ASPN contains an aspartic acid (D)-repeat domain and germline polymorphisms in D-repeat-length have been associated with degenerative diseases.	Aspartic Acid	17-30	asporin	Homo sapiens	0-4
26772541-10	2016	A novel mutation (c.86A &gt; CC) was identified on exon 3 [corrected] of the APOC2 gene, which converted the Asp [corrected] codon at position 29 into Ala, followed by a termination codon (TGA).	Aspartic Acid	109-112	T-box transcription factor 1	Homo sapiens	189-192
26598521-8	2016	Finally, further supporting a positive role for Runx1 tyrosine phosphorylation during granulopoiesis, mutation of the five Src-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa and granulocyte colony formation by Runx1-deleted murine marrow.	Aspartic Acid	148-157	Rous sarcoma oncogene	Mus musculus	123-126
26598521-8	2016	Finally, further supporting a positive role for Runx1 tyrosine phosphorylation during granulopoiesis, mutation of the five Src-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa and granulocyte colony formation by Runx1-deleted murine marrow.	Aspartic Acid	148-157	runt related transcription factor 1	Mus musculus	187-192
26598521-3	2016	Mutation of the four Runx1 C-terminal tyrosines to aspartate or glutamate to mimic phosphorylation increases trans-activation of the reporter in 293T cells and allows induction of Cebpa or Pu.1 mRNAs in 32Dcl3 myeloid cells, whereas mutation of these residues to phenylalanine to prevent phosphorylation obviates these effects.	Aspartic Acid	51-60	RUNX family transcription factor 1	Homo sapiens	21-26
26598521-5	2016	Mutation of the five modified Runx1 tyrosines to aspartate markedly reduced co-immunoprecipitation with HDAC1 and HDAC3, markedly increased stability in cycloheximide or in the presence of co-expressed Cdh1, an E3 ubiquitin ligase coactivator, with reduced ubiquitination, and allowed DNA-binding in gel shift assay similar to wild-type Runx1.	Aspartic Acid	49-58	runt related transcription factor 1	Mus musculus	30-35
26598521-5	2016	Mutation of the five modified Runx1 tyrosines to aspartate markedly reduced co-immunoprecipitation with HDAC1 and HDAC3, markedly increased stability in cycloheximide or in the presence of co-expressed Cdh1, an E3 ubiquitin ligase coactivator, with reduced ubiquitination, and allowed DNA-binding in gel shift assay similar to wild-type Runx1.	Aspartic Acid	49-58	histone deacetylase 1	Mus musculus	104-109
26598521-8	2016	Finally, further supporting a positive role for Runx1 tyrosine phosphorylation during granulopoiesis, mutation of the five Src-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa and granulocyte colony formation by Runx1-deleted murine marrow.	Aspartic Acid	148-157	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	205-210
26598521-8	2016	Finally, further supporting a positive role for Runx1 tyrosine phosphorylation during granulopoiesis, mutation of the five Src-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa and granulocyte colony formation by Runx1-deleted murine marrow.	Aspartic Acid	148-157	runt related transcription factor 1	Mus musculus	187-192
26727495-5	2016	A cDNA harboring mutations of conserved catalytic aspartate residues in the polymerase domain of REV3L could not rescue these phenotypes.	Aspartic Acid	50-59	REV3 like, DNA directed polymerase zeta catalytic subunit	Mus musculus	97-102
26598521-5	2016	Mutation of the five modified Runx1 tyrosines to aspartate markedly reduced co-immunoprecipitation with HDAC1 and HDAC3, markedly increased stability in cycloheximide or in the presence of co-expressed Cdh1, an E3 ubiquitin ligase coactivator, with reduced ubiquitination, and allowed DNA-binding in gel shift assay similar to wild-type Runx1.	Aspartic Acid	49-58	histone deacetylase 3	Mus musculus	114-119
26598521-5	2016	Mutation of the five modified Runx1 tyrosines to aspartate markedly reduced co-immunoprecipitation with HDAC1 and HDAC3, markedly increased stability in cycloheximide or in the presence of co-expressed Cdh1, an E3 ubiquitin ligase coactivator, with reduced ubiquitination, and allowed DNA-binding in gel shift assay similar to wild-type Runx1.	Aspartic Acid	49-58	cadherin 1	Mus musculus	202-206
26598521-5	2016	Mutation of the five modified Runx1 tyrosines to aspartate markedly reduced co-immunoprecipitation with HDAC1 and HDAC3, markedly increased stability in cycloheximide or in the presence of co-expressed Cdh1, an E3 ubiquitin ligase coactivator, with reduced ubiquitination, and allowed DNA-binding in gel shift assay similar to wild-type Runx1.	Aspartic Acid	49-58	runt related transcription factor 1	Mus musculus	337-342
27108884-5	2016	Furthermore, we showed that the combination of aspartic acid and glutamic acid exhibited enhanced antiproliferative activity, and inhibited Akt phosphorylation.	Aspartic Acid	47-60	AKT serine/threonine kinase 1	Homo sapiens	140-143
27452168-1	2016	l-Asparaginase, an enzyme that catalyzes l-asparagine into aspartic acid and ammonia, has relevant applications in the pharmaceutical and food industry.	Aspartic Acid	59-72	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
27770857-1	2016	l-Asparaginase (EC 3.5.1.1) is an enzyme that catalyzes the hydrolysis of l-asparagine to l-aspartic acid.	Aspartic Acid	90-105	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
28203371-3	2016	This case report highlights ASP as an uncommon but important cause of ectopic ACTH secretion (EAS).	Aspartic Acid	28-31	proopiomelanocortin	Homo sapiens	78-82
26077029-6	2016	Amino acid analysis post the exposure of hCP to SAL revealed that aspartate, histidine, lysine, threonine and tyrosine residues were particularly sensitive.	Aspartic Acid	66-75	coproporphyrinogen oxidase	Homo sapiens	41-44
26742748-2	2016	Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content.	Aspartic Acid	95-98	fibronectin type III domain containing 5	Homo sapiens	131-137
26607485-2	2016	Pharmacokinetic studies have shown that insulin aspart, which is structurally identical to regular human insulin except for the replacement of a single proline amino acid with an aspartic acid residue, has a more physiologic time-action profile (i.e., reaches a higher peak and reaches that peak sooner) than regular human insulin.	Aspartic Acid	179-192	insulin	Homo sapiens	40-47
28203371-6	2016	Given this promising prognosis if recognised, ASP should be considered in the diagnostic workup of ACTH-dependent CS.	Aspartic Acid	46-49	proopiomelanocortin	Homo sapiens	99-103
26442479-13	2016	Simultaneous silencing of SN1/SN2 transporters increase Gln, glutathione, aspartate, alanine and glutamate contents (Panel B; marked in red) as compare to non-silenced astrocytes (Panel A).	Aspartic Acid	74-83	solute carrier family 38 member 3	Homo sapiens	26-29
26672444-1	2016	L-Asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia.	Aspartic Acid	101-116	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
26672444-1	2016	L-Asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia.	Aspartic Acid	101-116	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-43
26442479-4	2016	HPLC analyses of cell extracts of SN1/SN2 siRNA-treated (SN1/SN2-) astrocytes revealed a ~ 3.5-fold increase in Gln content and doubling of glutathione, aspartate, alanine and glutamate contents, as compared to SN1/SN2+ astrocytes.	Aspartic Acid	153-162	solute carrier family 38 member 3	Homo sapiens	34-41
26442479-4	2016	HPLC analyses of cell extracts of SN1/SN2 siRNA-treated (SN1/SN2-) astrocytes revealed a ~ 3.5-fold increase in Gln content and doubling of glutathione, aspartate, alanine and glutamate contents, as compared to SN1/SN2+ astrocytes.	Aspartic Acid	153-162	solute carrier family 38 member 3	Homo sapiens	34-37
26648553-4	2016	Mass spectrometric analysis revealed that the replacement of an aspartate residue with asparagine at amino acid position 120 was the biochemical difference between the two Ndufa10 isoforms.	Aspartic Acid	64-73	NADH:ubiquinone oxidoreductase subunit A10	Rattus norvegicus	172-179
26442479-6	2016	The atom percent excess (13) C values (given as M + 1) for alanine, aspartate and glutamate were decreased when the SN1/SN2- cells were incubated with [1-(13) C] glucose, while Gln consumption was not changed.	Aspartic Acid	68-77	solute carrier family 38 member 3	Homo sapiens	116-119
26613347-2	2016	Steady-state fluorescence experiments revealed an increase in the fluorescence intensity (FI) for Syn solutions at pH values 3 and 2, in comparison with pH7, and fluorescence decays indicated that the FI increase did not result from suppression of excited-state proton transfer from the tyrosines to aspartates and glutamates, exposure of tyrosines to more hydrophobic environments, or reduction of homo-energy transfer.	Aspartic Acid	300-310	synuclein alpha	Homo sapiens	98-101
27777497-11	2016	Moreover, glutamate and aspartate increased transforming growth factor-beta1 (TGF-beta1) and interleukin-10 (IL-10) levels in the epididymis and testis (P &lt; 0.05) compared with the BD group.	Aspartic Acid	24-33	transforming growth factor beta 1	Homo sapiens	78-87
27777497-11	2016	Moreover, glutamate and aspartate increased transforming growth factor-beta1 (TGF-beta1) and interleukin-10 (IL-10) levels in the epididymis and testis (P &lt; 0.05) compared with the BD group.	Aspartic Acid	24-33	interleukin 10	Homo sapiens	93-107
27777497-11	2016	Moreover, glutamate and aspartate increased transforming growth factor-beta1 (TGF-beta1) and interleukin-10 (IL-10) levels in the epididymis and testis (P &lt; 0.05) compared with the BD group.	Aspartic Acid	24-33	interleukin 10	Homo sapiens	109-114
26511318-8	2015	Caspase-3 activation by hyperosmotic shock induces proteolysis of Bid and mono-ubiquitinated Bid at Asp-52 increasing the release of cytochrome c and caspase-3 activation, and thus creating a second positive feedback loop.	Aspartic Acid	100-103	BH3 interacting domain death agonist	Homo sapiens	93-96
26272487-5	2016	A new Asp to Gly homozygous mutation at position 173 of ADAMTS-13 sequence was identified in a family of Romanian origin, with some members affected by clinical signs of TTP.	Aspartic Acid	6-9	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	56-65
26511318-4	2015	When caspase-3 is activated, JNK1-2 is proteolyzed at Asp-385 increasing the release of cytochrome c and caspase-3 activity, thereby creating a positive feedback loop.	Aspartic Acid	54-57	caspase 3	Homo sapiens	5-14
26511318-4	2015	When caspase-3 is activated, JNK1-2 is proteolyzed at Asp-385 increasing the release of cytochrome c and caspase-3 activity, thereby creating a positive feedback loop.	Aspartic Acid	54-57	mitogen-activated protein kinase 8	Homo sapiens	29-35
26511318-8	2015	Caspase-3 activation by hyperosmotic shock induces proteolysis of Bid and mono-ubiquitinated Bid at Asp-52 increasing the release of cytochrome c and caspase-3 activation, and thus creating a second positive feedback loop.	Aspartic Acid	100-103	cytochrome c, somatic	Homo sapiens	133-145
26511318-4	2015	When caspase-3 is activated, JNK1-2 is proteolyzed at Asp-385 increasing the release of cytochrome c and caspase-3 activity, thereby creating a positive feedback loop.	Aspartic Acid	54-57	cytochrome c, somatic	Homo sapiens	88-100
26511318-4	2015	When caspase-3 is activated, JNK1-2 is proteolyzed at Asp-385 increasing the release of cytochrome c and caspase-3 activity, thereby creating a positive feedback loop.	Aspartic Acid	54-57	caspase 3	Homo sapiens	105-114
26511318-8	2015	Caspase-3 activation by hyperosmotic shock induces proteolysis of Bid and mono-ubiquitinated Bid at Asp-52 increasing the release of cytochrome c and caspase-3 activation, and thus creating a second positive feedback loop.	Aspartic Acid	100-103	caspase 3	Homo sapiens	150-159
26511318-8	2015	Caspase-3 activation by hyperosmotic shock induces proteolysis of Bid and mono-ubiquitinated Bid at Asp-52 increasing the release of cytochrome c and caspase-3 activation, and thus creating a second positive feedback loop.	Aspartic Acid	100-103	caspase 3	Homo sapiens	0-9
25758062-7	2015	The results indicate that carboxyl groups of both l-beta-Asp and D-alpha-Asp were recognized in similar modes by PIMT and that the C-terminal regions of substrate peptides were located in similar positions on PIMT for both the l-beta-Asp and D-alpha-Asp peptides.	Aspartic Acid	57-60	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	113-117
25596033-6	2015	In these methods, recombinant human DDO was used to degrade D-Asp formed from L-Asp by the Asp racemase reaction to 2-oxo acid, the amounts of which were then determined using a colorimetric assay.	Aspartic Acid	78-83	D-aspartate oxidase	Homo sapiens	36-39
25596033-6	2015	In these methods, recombinant human DDO was used to degrade D-Asp formed from L-Asp by the Asp racemase reaction to 2-oxo acid, the amounts of which were then determined using a colorimetric assay.	Aspartic Acid	62-65	D-aspartate oxidase	Homo sapiens	36-39
25596033-7	2015	In one method, designated the coupling method, DDO was concomitantly included in the Asp racemase reaction mixture, and the Asp racemase reaction was readily coupled to the D-Asp degradative reaction by DDO during the incubation.	Aspartic Acid	85-88	D-aspartate oxidase	Homo sapiens	47-50
25596033-7	2015	In one method, designated the coupling method, DDO was concomitantly included in the Asp racemase reaction mixture, and the Asp racemase reaction was readily coupled to the D-Asp degradative reaction by DDO during the incubation.	Aspartic Acid	85-88	D-aspartate oxidase	Homo sapiens	203-206
25596033-7	2015	In one method, designated the coupling method, DDO was concomitantly included in the Asp racemase reaction mixture, and the Asp racemase reaction was readily coupled to the D-Asp degradative reaction by DDO during the incubation.	Aspartic Acid	124-127	D-aspartate oxidase	Homo sapiens	203-206
26058797-4	2015	In the present study, the amounts of Asp and Glu enantiomers in 6 brain tissues, 11 peripheral tissues and 2 physiological fluids of DDO(+/+), DDO(+/-) and DDO(-/-) mice were determined using a sensitive and selective two-dimensional HPLC system.	Aspartic Acid	37-40	D-aspartate oxidase	Mus musculus	133-136
25758062-7	2015	The results indicate that carboxyl groups of both l-beta-Asp and D-alpha-Asp were recognized in similar modes by PIMT and that the C-terminal regions of substrate peptides were located in similar positions on PIMT for both the l-beta-Asp and D-alpha-Asp peptides.	Aspartic Acid	57-60	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	209-213
26656683-11	2016	We found that the mutation of glycine (G) to aspartic acid (D) at position 622 in PB1 partially impairs the binding of PB1 to viral RNA, thereby attenuating H5N1 virus virulence in mice.	Aspartic Acid	45-58	polybromo 1	Mus musculus	119-122
26656683-5	2016	We further demonstrated that the mutation of glycine (G) to aspartic acid (D) at position 622 in PB1 partially impaired the binding of PB1 to viral RNA, thereby dramatically decreasing the polymerase activity and attenuating H5N1 virus virulence in mice.	Aspartic Acid	60-73	polybromo 1	Mus musculus	97-100
26210154-10	2015	The method of pK calculation was applied successfully also for dissociation of Asp 26 in bacterial thioredoxin.	Aspartic Acid	79-82	thioredoxin	Homo sapiens	99-110
26656683-5	2016	We further demonstrated that the mutation of glycine (G) to aspartic acid (D) at position 622 in PB1 partially impaired the binding of PB1 to viral RNA, thereby dramatically decreasing the polymerase activity and attenuating H5N1 virus virulence in mice.	Aspartic Acid	60-73	polybromo 1	Mus musculus	135-138
26656683-11	2016	We found that the mutation of glycine (G) to aspartic acid (D) at position 622 in PB1 partially impairs the binding of PB1 to viral RNA, thereby attenuating H5N1 virus virulence in mice.	Aspartic Acid	45-58	polybromo 1	Mus musculus	82-85
26468287-9	2015	The specificity for binding to LC3A/B is due to the interaction between Asp(1285) in FYCO1 and His(57) in LC3B.	Aspartic Acid	72-75	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	31-37
26468287-9	2015	The specificity for binding to LC3A/B is due to the interaction between Asp(1285) in FYCO1 and His(57) in LC3B.	Aspartic Acid	72-75	FYVE and coiled-coil domain autophagy adaptor 1	Homo sapiens	85-90
26468287-9	2015	The specificity for binding to LC3A/B is due to the interaction between Asp(1285) in FYCO1 and His(57) in LC3B.	Aspartic Acid	72-75	microtubule associated protein 1 light chain 3 beta	Homo sapiens	106-110
26632449-4	2015	The ASP emerges from the tracheal branch that connects to the wing disc by the activation of both Bnl-FGF/Btl and EGFR signaling pathways.	Aspartic Acid	4-7	branchless	Drosophila melanogaster	102-105
26632449-4	2015	The ASP emerges from the tracheal branch that connects to the wing disc by the activation of both Bnl-FGF/Btl and EGFR signaling pathways.	Aspartic Acid	4-7	breathless	Drosophila melanogaster	106-109
26632449-4	2015	The ASP emerges from the tracheal branch that connects to the wing disc by the activation of both Bnl-FGF/Btl and EGFR signaling pathways.	Aspartic Acid	4-7	Epidermal growth factor receptor	Drosophila melanogaster	114-118
26632449-6	2015	In this study we demonstrate that Vein (vn) is the EGF ligand responsible for the activation of the EGFR pathway in the ASP.	Aspartic Acid	120-123	vein	Drosophila melanogaster	34-38
26632449-6	2015	In this study we demonstrate that Vein (vn) is the EGF ligand responsible for the activation of the EGFR pathway in the ASP.	Aspartic Acid	120-123	Epidermal growth factor receptor	Drosophila melanogaster	100-104
26632449-8	2015	Furthermore, we show that the FGF target gene escargot (esg) attenuates EGFR signaling at the tip cells of the developing ASP, reducing their mitotic rate to allow proper migration.	Aspartic Acid	122-125	branchless	Drosophila melanogaster	30-33
26632449-8	2015	Furthermore, we show that the FGF target gene escargot (esg) attenuates EGFR signaling at the tip cells of the developing ASP, reducing their mitotic rate to allow proper migration.	Aspartic Acid	122-125	escargot	Drosophila melanogaster	56-59
26632449-8	2015	Furthermore, we show that the FGF target gene escargot (esg) attenuates EGFR signaling at the tip cells of the developing ASP, reducing their mitotic rate to allow proper migration.	Aspartic Acid	122-125	Epidermal growth factor receptor	Drosophila melanogaster	72-76
26508545-3	2015	We designed and synthesized a novel series of Pin1 inhibitors based on a glutamic acid or aspartic acid scaffold bearing an aromatic moiety to provide a hydrophobic surface and a cyclic aliphatic amine moiety with affinity for the proline-binding site of Pin1.	Aspartic Acid	90-103	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	46-50
26302489-16	2015	A motif of histidine, proline, and aspartic acid in the J domain of DNAJB6a was required for its tumor-suppressive effects and signaling via AKT1.	Aspartic Acid	35-48	AKT serine/threonine kinase 1	Homo sapiens	141-145
26781794-4	2015	The 4-(4-(dimethylamino) styryl)-N-methylpyridinium iodide (ASP) assay was used to detect dynamic 5-HT uptake as read out of SERT activities in RBL-2H3 cells, and cytosol Ca(2+) concentrations ([Ca(2+)]i) and nitric oxide (NO) were examined.	Aspartic Acid	60-63	solute carrier family 6 member 4	Rattus norvegicus	125-129
26221781-6	2015	An increased level of aspartate was observed upon exposure to [U-(13) C]glutamate in astrocytes exhibiting reduced GDH activity.	Aspartic Acid	22-31	glutamate dehydrogenase 1	Homo sapiens	115-118
26221781-8	2015	(13) C Glucose metabolism was elevated in GDH deficient astrocytes as observed by increased de novo synthesis of aspartate via pyruvate carboxylation.	Aspartic Acid	113-122	glutamate dehydrogenase 1	Homo sapiens	42-45
26443379-6	2015	We report that replacing serine with a phospho-mimetic aspartic acid at position 798 completely abrogates association of Ago2 with P-bodies and stress granules.	Aspartic Acid	55-68	argonaute RISC catalytic component 2	Homo sapiens	121-125
26021842-5	2015	RESULTS: One patient was found to have a new mutation in exon 6: g67.258,286 (G/A) heterozygote; (GGC/GAC; gly/asp).	Aspartic Acid	111-114	gamma-glutamylcyclotransferase	Homo sapiens	98-101
26021842-6	2015	Apart from this new mutation, previously defined synonymous mutations in AIP gene were detected in seven patients (Exon 4; rs2276020; (GAC/GAT; asp/asp) and six patients were found to have five different intronic mutations in AIP gene which were not previously defined.	Aspartic Acid	144-147	aryl hydrocarbon receptor interacting protein	Homo sapiens	73-76
26021842-6	2015	Apart from this new mutation, previously defined synonymous mutations in AIP gene were detected in seven patients (Exon 4; rs2276020; (GAC/GAT; asp/asp) and six patients were found to have five different intronic mutations in AIP gene which were not previously defined.	Aspartic Acid	148-151	aryl hydrocarbon receptor interacting protein	Homo sapiens	73-76
26519531-7	2015	In this study, we demonstrate that the leucine-rich hydrophobic sequence stretches (with the central leucine residues L20 and L66) in the first and second TM helix of TAP2 form a functional unit acting as a docking site for optimal TPN/MHC I recruitment, whereas three distinct highly conserved arginine and/or aspartate residues inside or flanking these TM helices are dispensable.	Aspartic Acid	311-320	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	167-171
26519531-7	2015	In this study, we demonstrate that the leucine-rich hydrophobic sequence stretches (with the central leucine residues L20 and L66) in the first and second TM helix of TAP2 form a functional unit acting as a docking site for optimal TPN/MHC I recruitment, whereas three distinct highly conserved arginine and/or aspartate residues inside or flanking these TM helices are dispensable.	Aspartic Acid	311-320	TAP binding protein	Homo sapiens	232-235
26625273-4	2015	In this work all Asp residues of human beta2m were individually substituted to Asn; D-to-N mutants (D34N, D38N, D53N, D59N, D96N and D98N) were characterised in terms of thermodynamic stability and aggregation propensity.	Aspartic Acid	17-20	beta-2-microglobulin	Homo sapiens	39-45
26567716-5	2015	The activity of the organic cation transporter 2 (OCT2) in ciPTEC was evaluated in real-time using a perfusion system by confocal microscopy using 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP(+)) as a fluorescent substrate.	Aspartic Acid	202-208	solute carrier family 22 member 2	Homo sapiens	20-48
26124006-10	2015	In addition, NSCLC patients carrying combined C/C genotype at codon 324 in BAG-1, Asp/Asp of XPD codon 312, and Lys/Lys of XPD codon 751 produced a higher efficacy of NP chemotherapy compared to those carrying mutation genotypes (all P &lt; 0.05).	Aspartic Acid	82-85	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	93-96
26124006-10	2015	In addition, NSCLC patients carrying combined C/C genotype at codon 324 in BAG-1, Asp/Asp of XPD codon 312, and Lys/Lys of XPD codon 751 produced a higher efficacy of NP chemotherapy compared to those carrying mutation genotypes (all P &lt; 0.05).	Aspartic Acid	86-89	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	93-96
26598711-6	2015	Despite having a different main chain conformation to that seen in the PACAP21 structure, four conserved residues (equivalent to His-7, Glu-9, Ser-14 and Asp-15 in GLP-1) could be structurally aligned and made similar interactions with the receptor as their equivalents in the GLP-1-docked model, suggesting the basis of a pharmacophore for GLP-1R peptide agonists.	Aspartic Acid	154-157	glucagon	Homo sapiens	164-169
26560030-2	2015	Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea.	Aspartic Acid	122-131	argininosuccinate synthase 1	Homo sapiens	0-26
26560030-2	2015	Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea.	Aspartic Acid	122-131	argininosuccinate synthase 1	Homo sapiens	28-32
26560030-8	2015	Building on these results, we demonstrate that ASS1 deficiency in cancer increases cytosolic aspartate levels, which increases CAD activation by upregulating its substrate availability and by increasing its phosphorylation by S6K1 through the mammalian target of rapamycin (mTOR) pathway.	Aspartic Acid	93-102	mechanistic target of rapamycin kinase	Homo sapiens	243-272
26560030-8	2015	Building on these results, we demonstrate that ASS1 deficiency in cancer increases cytosolic aspartate levels, which increases CAD activation by upregulating its substrate availability and by increasing its phosphorylation by S6K1 through the mammalian target of rapamycin (mTOR) pathway.	Aspartic Acid	93-102	mechanistic target of rapamycin kinase	Homo sapiens	274-278
26571381-10	2015	Mutation of the Aspartic Acid residue that is conserved in the pseudouridine synthase domain present in GSE4 did not impair its activity, except for the repression of c-myc promoter activity and the decrease of c-myc, TERT and TERC gene expression in dyskerin-mutated cells.	Aspartic Acid	16-29	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	211-216
26571381-10	2015	Mutation of the Aspartic Acid residue that is conserved in the pseudouridine synthase domain present in GSE4 did not impair its activity, except for the repression of c-myc promoter activity and the decrease of c-myc, TERT and TERC gene expression in dyskerin-mutated cells.	Aspartic Acid	16-29	telomerase reverse transcriptase	Homo sapiens	218-222
26571381-10	2015	Mutation of the Aspartic Acid residue that is conserved in the pseudouridine synthase domain present in GSE4 did not impair its activity, except for the repression of c-myc promoter activity and the decrease of c-myc, TERT and TERC gene expression in dyskerin-mutated cells.	Aspartic Acid	16-29	telomerase RNA component	Homo sapiens	227-231
26567716-5	2015	The activity of the organic cation transporter 2 (OCT2) in ciPTEC was evaluated in real-time using a perfusion system by confocal microscopy using 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP(+)) as a fluorescent substrate.	Aspartic Acid	202-208	solute carrier family 22 member 2	Homo sapiens	50-54
26567716-6	2015	Initial ASP(+) uptake was inhibited by a cationic uremic metabolites mixture and by the histamine H2-receptor antagonist, cimetidine.	Aspartic Acid	8-14	histamine receptor H2	Homo sapiens	88-109
26405039-3	2015	Replacement of an absolutely conserved Asp by charge reversal (D478E), neutralization (D478N), or even exchange (D478E) abolished MPP(+) uptake, demonstrating this residue to be obligatory for OCT3-mediated transport.	Aspartic Acid	39-42	OCTN3	Homo sapiens	193-197
26522426-5	2015	In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the depleted pool of aspartate in SDH-deficient cells.	Aspartic Acid	103-112	pyruvate carboxylase	Homo sapiens	35-55
26396192-8	2015	Due to an Asp or Glu at amino acid 178 differentiating these APOBEC3H haplotypes, the data indicated that this amino acid on helix 6 contributes to processivity.	Aspartic Acid	10-13	apolipoprotein B mRNA editing enzyme catalytic subunit 3H	Homo sapiens	61-69
26522426-5	2015	In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the depleted pool of aspartate in SDH-deficient cells.	Aspartic Acid	103-112	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	116-119
26183761-13	2015	Surprisingly, mutations at Glu, Asp or Asn residues in the hydrophobic core that are known to be essential for Ca(2+)-induced activation of ANO1 blocked the acid-induced inhibition.	Aspartic Acid	32-35	anoctamin 1	Homo sapiens	140-144
26553637-3	2015	It is known that acidic serine- and aspartate-rich motif (ASARM) as a small peptide released by matrix extracellular phosphoglycoprotein (MEPE) promotes osteopenia.	Aspartic Acid	36-45	matrix extracellular phosphoglycoprotein	Homo sapiens	96-136
26062933-1	2015	PURPOSE: The aim of this study was to investigate the biodistribution of 2-fluoropropionyl-labeled PEGylated dimeric arginine-glycine-aspartic acid (RGD) peptide (PEG3-E[c{RGDyk}]2) ((18)F-FPPRGD2) in cancer patients and to compare its uptake in malignant lesions with (18)F-FDG uptake.	Aspartic Acid	134-147	paternally expressed 3	Homo sapiens	163-167
26382650-6	2015	Aligning the primary structures of functionally characterized LPT1 homologs from fungi, plants, and animals identified 11 conserved aspartate, glutamate, lysine, threonine, and tyrosine residues.	Aspartic Acid	132-141	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	62-66
26401995-1	2015	The brain aspartate-glutamate carrier (AGC1) is specifically expressed in neurons, where it transports aspartate from the mitochondria to the cytosol, and plays a role in transfer of nicotinamide adenine dinucleotide (NADH)-reducing equivalents into the mitochondria as a part of the malate-aspartate shuttle.	Aspartic Acid	10-19	aggrecan	Homo sapiens	39-43
26401995-1	2015	The brain aspartate-glutamate carrier (AGC1) is specifically expressed in neurons, where it transports aspartate from the mitochondria to the cytosol, and plays a role in transfer of nicotinamide adenine dinucleotide (NADH)-reducing equivalents into the mitochondria as a part of the malate-aspartate shuttle.	Aspartic Acid	103-112	aggrecan	Homo sapiens	39-43
26401995-1	2015	The brain aspartate-glutamate carrier (AGC1) is specifically expressed in neurons, where it transports aspartate from the mitochondria to the cytosol, and plays a role in transfer of nicotinamide adenine dinucleotide (NADH)-reducing equivalents into the mitochondria as a part of the malate-aspartate shuttle.	Aspartic Acid	103-112	aggrecan	Homo sapiens	39-43
26382650-4	2015	In vitro Lpt1p assays with amino acid modifying agents implicated aspartate, glutamate, and lysine as active site residues.	Aspartic Acid	66-75	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	9-14
26553637-3	2015	It is known that acidic serine- and aspartate-rich motif (ASARM) as a small peptide released by matrix extracellular phosphoglycoprotein (MEPE) promotes osteopenia.	Aspartic Acid	36-45	matrix extracellular phosphoglycoprotein	Homo sapiens	138-142
26512077-2	2016	Although viruses from raccoons do not efficiently bind the dog transferrin receptor (TfR) or infect dog cells, a single mutation changing an aspartic acid to a glycine at capsid (VP2) position 300 in the prototype raccoon CPV allows dog cell infection.	Aspartic Acid	141-154	VP2	Canine parvovirus	179-182
26327310-7	2015	Cysteine sulfinic acid was the preferred substrate for both mouse CSAD and GADL1, although both enzymes also decarboxylated cysteic acid and aspartate.	Aspartic Acid	141-150	cysteine sulfinic acid decarboxylase	Mus musculus	66-70
26327310-7	2015	Cysteine sulfinic acid was the preferred substrate for both mouse CSAD and GADL1, although both enzymes also decarboxylated cysteic acid and aspartate.	Aspartic Acid	141-150	glutamate decarboxylase-like 1	Mus musculus	75-80
26509711-0	2015	IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Ialpha and IIalpha through Conserved Catalytic Aspartate Residues.	Aspartic Acid	133-142	S-adenosylhomocysteine hydrolase-like 1	Mus musculus	0-5
26509711-5	2015	Site-directed mutagenesis revealed that two conserved catalytic aspartate residues of PIPKIalpha and PIPKIIalpha are involved in the interaction with IRBIT.	Aspartic Acid	64-73	S-adenosylhomocysteine hydrolase-like 1	Mus musculus	150-155
25965900-1	2015	PURPOSE: To prospectively evaluate fluorine 18 ((18)F) 2-fluoropropionyl-labeled PEGylated dimeric arginine-glycine-aspartic acid (RGD) peptide (PEG3-E[c{RGDyk}]2) (FPPRGD2) positron emission tomography (PET) in patients with glioblastoma multiforme (GBM).	Aspartic Acid	116-129	paternally expressed 3	Homo sapiens	145-149
26499495-3	2015	Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine, produced the strongest inhibitory effect on sarcoma growth in a functional genomic screen of mouse sarcomas generated by oncogenic Kras and disruption of Cdkn2a.	Aspartic Acid	77-86	asparagine synthetase	Mus musculus	13-34
26499495-3	2015	Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine, produced the strongest inhibitory effect on sarcoma growth in a functional genomic screen of mouse sarcomas generated by oncogenic Kras and disruption of Cdkn2a.	Aspartic Acid	77-86	asparagine synthetase	Mus musculus	36-40
26528183-12	2015	This new information positions the malate-aspartate shuttle as a key player in the oxidative metabolism of lactate: similar to glycolysis that aliments OXPHOS with pyruvate produced by pyruvate kinase and NADH produced by glyceraldehyde-3-phosphate dehydrogenase (GAPDH), oxidative lactate metabolism aliments OXPHOS in oxidative tumor cells with pyruvate and NADH produced by LDH1.	Aspartic Acid	42-51	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	222-262
26397724-4	2015	Molecular docking of 1 to an X-ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(113) and Asp(171) and the (pyridin-2-ylmethyl)amino moiety is anchored by Asp(262) and His(281), whereas the naphthalene ring is tightly packed in a hydrophobic subpocket formed by the aromatic side chains of Trp(94), Tyr(45), and Tyr(116).	Aspartic Acid	140-143	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
26397724-4	2015	Molecular docking of 1 to an X-ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(113) and Asp(171) and the (pyridin-2-ylmethyl)amino moiety is anchored by Asp(262) and His(281), whereas the naphthalene ring is tightly packed in a hydrophobic subpocket formed by the aromatic side chains of Trp(94), Tyr(45), and Tyr(116).	Aspartic Acid	205-208	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
26466095-8	2015	Moreover, the hRpn2-derived peptide was no longer able to interact with endogenous hRpn13 when a strictly conserved phenylalanine (F948 in humans) was replaced with arginine or a stop codon, or when Y950 and I951 were substituted with aspartic acid.	Aspartic Acid	235-248	ribophorin II	Homo sapiens	14-19
26528183-12	2015	This new information positions the malate-aspartate shuttle as a key player in the oxidative metabolism of lactate: similar to glycolysis that aliments OXPHOS with pyruvate produced by pyruvate kinase and NADH produced by glyceraldehyde-3-phosphate dehydrogenase (GAPDH), oxidative lactate metabolism aliments OXPHOS in oxidative tumor cells with pyruvate and NADH produced by LDH1.	Aspartic Acid	42-51	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	264-269
26341534-3	2015	We find that CP1 is expressed in ASP and knockdown of CP1 results in suppression of migratory and invasive behavior observed during ASP development.	Aspartic Acid	33-36	Cysteine proteinase-1	Drosophila melanogaster	13-16
26528249-4	2015	A conserved aspartate residue (D105) in putative transmembrane helix 4 was identified, which was essential for the energy dependent ethidium bromide efflux by BC3310.	Aspartic Acid	12-21	MFS transporter	Bacillus cereus ATCC 14579	159-165
26370006-4	2015	We suggest that mutations in mid-exon 18 corresponding to the C-terminal end of the acidic (Asp/Glu-rich) domain of KAT6B may have more variable expressivity leading to GPS, SBBYSS or combined phenotypes, in contrast to defects in other regions of the gene which contribute more specifically to either GPS or SBBYSS.	Aspartic Acid	92-95	lysine acetyltransferase 6B	Homo sapiens	116-121
26153465-0	2015	A breeding experiment confirms the dominant mode of inheritance of the brown coat colour associated with the (496) Asp TYRP1 allele in goats.	Aspartic Acid	115-118	5,6-dihydroxyindole-2-carboxylic acid oxidase	Capra hircus	119-124
25988244-10	2015	Similarly, aggregation in the dry ASP was strongly reduced by LEA7.	Aspartic Acid	34-37	Late embryogenesis abundant protein (LEA) family protein	Arabidopsis thaliana	62-66
26173648-9	2015	A homozygous mutation A1103G in exon 8 of DSG4 was identified in the patient, resulting in the substitution of an aspartic acid by glycine (D323G) and reduced DSG4 expression in the affected scalp epidermis.	Aspartic Acid	114-127	desmoglein 4	Homo sapiens	42-46
26173648-9	2015	A homozygous mutation A1103G in exon 8 of DSG4 was identified in the patient, resulting in the substitution of an aspartic acid by glycine (D323G) and reduced DSG4 expression in the affected scalp epidermis.	Aspartic Acid	114-127	desmoglein 4	Homo sapiens	159-163
26269602-7	2015	The Asp-102 and Ala-285 variants are more stable than wild-type rhodanese and exhibit kcat/Km,CN values that are 17- and 1.6-fold higher, respectively.	Aspartic Acid	4-7	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	64-73
26382053-3	2015	There are a number of DEAD (Asp-Glu-Ala-Asp; DExD/H) box-type helicases in mammals, among which retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA50) are indispensable for RNA sensing; however, they are functionally supported by a number of sensors that directly bind viral RNA or replicative RNA intermediates to convey signals to RIG-I and MDA5.	Aspartic Acid	28-31	interferon induced with helicase C domain 1	Gallus gallus	139-184
26382053-3	2015	There are a number of DEAD (Asp-Glu-Ala-Asp; DExD/H) box-type helicases in mammals, among which retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA50) are indispensable for RNA sensing; however, they are functionally supported by a number of sensors that directly bind viral RNA or replicative RNA intermediates to convey signals to RIG-I and MDA5.	Aspartic Acid	28-31	interferon induced with helicase C domain 1	Gallus gallus	186-190
26382053-3	2015	There are a number of DEAD (Asp-Glu-Ala-Asp; DExD/H) box-type helicases in mammals, among which retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA50) are indispensable for RNA sensing; however, they are functionally supported by a number of sensors that directly bind viral RNA or replicative RNA intermediates to convey signals to RIG-I and MDA5.	Aspartic Acid	40-43	interferon induced with helicase C domain 1	Gallus gallus	139-184
26382053-3	2015	There are a number of DEAD (Asp-Glu-Ala-Asp; DExD/H) box-type helicases in mammals, among which retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA50) are indispensable for RNA sensing; however, they are functionally supported by a number of sensors that directly bind viral RNA or replicative RNA intermediates to convey signals to RIG-I and MDA5.	Aspartic Acid	40-43	interferon induced with helicase C domain 1	Gallus gallus	186-190
26238930-1	2015	Previous studies have demonstrated that the alpha5beta1 integrin-mediated interaction with fibronectin (FN) occurs through the Arg-Gly-Asp (RGD) cell-binding sequence in repeat III10.	Aspartic Acid	135-138	fibronectin 1	Homo sapiens	91-102
26332741-6	2015	The Asp   Asn mutation in the GY/FDFLGL motif abolishes the interaction between MYB transcription factors and SAD2, and therefore they cannot be transported into the nucleus and cannot repress their target genes.	Aspartic Acid	4-7	ARM repeat superfamily protein	Arabidopsis thaliana	110-114
27183783-5	2015	In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly.	Aspartic Acid	101-104	growth differentiation factor 15	Homo sapiens	17-22
27183783-5	2015	In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly.	Aspartic Acid	101-104	growth differentiation factor 15	Homo sapiens	23-28
27183783-5	2015	In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly.	Aspartic Acid	118-121	growth differentiation factor 15	Homo sapiens	17-22
27183783-5	2015	In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly.	Aspartic Acid	118-121	growth differentiation factor 15	Homo sapiens	23-28
26260792-3	2015	Crystallization of A-CAT in the presence of MgATP yielded structures with AMP or adenosine in the catalytic cleft together with a phosphorylated Asp-766 residue.	Aspartic Acid	145-148	carboxylesterase 1	Homo sapiens	19-24
26269602-9	2015	The kcat/Km,sulfite values for the variants in the sulfur transfer reaction from GSSH to sulfite were 1.6- (Asp-102) and 4-fold (Ala-285) lower than for wild-type rhodanese, whereas the kcat/Km,GSSH values were similar for all three enzymes.	Aspartic Acid	108-111	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	163-172
26266342-6	2015	The binding behavior of hKDM5B-PHD1 and hBAZ2A-PHD is similar, and like PHD H3R2 readers, both possess a pair of Asp residues in the treble clef for interaction with H3R2.	Aspartic Acid	113-116	egl-9 family hypoxia inducible factor 2	Homo sapiens	24-35
26401656-6	2015	Based on an integrative analysis of expression quantitative trait loci in blood mononuclear cells and correlations between gene expressions and metabolite levels, we provide evidence for putative causative genes: SLC22A16 for total acylcarnitines, ARG1 for arginine, HLCS for 2-hydroxyisovalerylcarnitine, JAM3 for stearoylcarnitine via a trans-effect at chromosome 1, and PPP1R16A for aspartic acid traits.	Aspartic Acid	386-399	solute carrier family 22 member 16	Homo sapiens	213-221
26401656-6	2015	Based on an integrative analysis of expression quantitative trait loci in blood mononuclear cells and correlations between gene expressions and metabolite levels, we provide evidence for putative causative genes: SLC22A16 for total acylcarnitines, ARG1 for arginine, HLCS for 2-hydroxyisovalerylcarnitine, JAM3 for stearoylcarnitine via a trans-effect at chromosome 1, and PPP1R16A for aspartic acid traits.	Aspartic Acid	386-399	holocarboxylase synthetase	Homo sapiens	267-271
26401656-6	2015	Based on an integrative analysis of expression quantitative trait loci in blood mononuclear cells and correlations between gene expressions and metabolite levels, we provide evidence for putative causative genes: SLC22A16 for total acylcarnitines, ARG1 for arginine, HLCS for 2-hydroxyisovalerylcarnitine, JAM3 for stearoylcarnitine via a trans-effect at chromosome 1, and PPP1R16A for aspartic acid traits.	Aspartic Acid	386-399	junctional adhesion molecule 3	Homo sapiens	306-310
26401656-6	2015	Based on an integrative analysis of expression quantitative trait loci in blood mononuclear cells and correlations between gene expressions and metabolite levels, we provide evidence for putative causative genes: SLC22A16 for total acylcarnitines, ARG1 for arginine, HLCS for 2-hydroxyisovalerylcarnitine, JAM3 for stearoylcarnitine via a trans-effect at chromosome 1, and PPP1R16A for aspartic acid traits.	Aspartic Acid	386-399	protein phosphatase 1 regulatory subunit 16A	Homo sapiens	373-381
26406119-4	2015	Genomic integration activity of PGBD5 requires distinct aspartic acid residues in its transposase domain, and specific DNA sequences containing inverted terminal repeats with similarity to piggyBac transposons.	Aspartic Acid	56-69	piggyBac transposable element derived 5	Homo sapiens	32-37
26266342-8	2015	These Asp residues make significant energetic contributions to the formation of the hKDM5B-histone peptide complex, suggesting that there are interactions in addition to those reported in the recent NMR structure.	Aspartic Acid	6-9	lysine demethylase 5B	Homo sapiens	84-90
26322377-9	2015	A similarly positioned aspartate or glutamate also occurs in the homologous enzymes LeuRS, IleRS, and ValRS, which also discriminate against Hcy.	Aspartic Acid	23-32	leucyl-tRNA synthetase 2, mitochondrial	Homo sapiens	84-89
26322377-9	2015	A similarly positioned aspartate or glutamate also occurs in the homologous enzymes LeuRS, IleRS, and ValRS, which also discriminate against Hcy.	Aspartic Acid	23-32	isoleucyl-tRNA synthetase 2, mitochondrial	Homo sapiens	91-96
26322377-9	2015	A similarly positioned aspartate or glutamate also occurs in the homologous enzymes LeuRS, IleRS, and ValRS, which also discriminate against Hcy.	Aspartic Acid	23-32	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	102-107
26442064-11	2015	Further, "Expasy ProtParam tool" results showed that Iris x hollandica DFR amino acids (Asn 9: Asp 23) are favorable for reducing DHQ and DHM thus accumulating delphinidin, while Gossypium hirsutum DFR has (Asn 13: Asp 21) hypothesized to consume DHK.	Aspartic Acid	95-98	putative anthocyanidin reductase	Gossypium hirsutum	71-74
26442064-11	2015	Further, "Expasy ProtParam tool" results showed that Iris x hollandica DFR amino acids (Asn 9: Asp 23) are favorable for reducing DHQ and DHM thus accumulating delphinidin, while Gossypium hirsutum DFR has (Asn 13: Asp 21) hypothesized to consume DHK.	Aspartic Acid	95-98	putative anthocyanidin reductase	Gossypium hirsutum	198-201
26442064-11	2015	Further, "Expasy ProtParam tool" results showed that Iris x hollandica DFR amino acids (Asn 9: Asp 23) are favorable for reducing DHQ and DHM thus accumulating delphinidin, while Gossypium hirsutum DFR has (Asn 13: Asp 21) hypothesized to consume DHK.	Aspartic Acid	215-218	putative anthocyanidin reductase	Gossypium hirsutum	71-74
26271101-4	2015	RNA bisulfite sequencing revealed that Dnmt2 methylates C38 of tRNA Asp(GTC), Gly(GCC), and Val(AAC), thus preventing tRNA fragmentation.	Aspartic Acid	68-71	tRNA aspartic acid methyltransferase 1	Mus musculus	39-44
26021431-7	2015	The maximum adsorption capacity of glutamic acid and aspartic acid onto calcium oxalate monohydrate crystals are 0.059 and 0.066mumol/g at pH 4, respectively.	Aspartic Acid	53-66	prolyl 4-hydroxylase, transmembrane	Homo sapiens	139-143
26195627-0	2015	Analysis of Conserved Glutamate and Aspartate Residues in Drosophila Rhodopsin 1 and Their Influence on Spectral Tuning.	Aspartic Acid	36-45	neither inactivation nor afterpotential E	Drosophila melanogaster	69-80
32262469-2	2015	The repetitive nucleotide sequence of aspartate-serine-serine (DSS) is the fundamental unit within DPP, and peptides containing 8 repeats of DSS (8DSS) have been shown to possess the ability to induce remineralization of the demineralized enamel.	Aspartic Acid	38-47	dentin sialophosphoprotein	Homo sapiens	99-102
26164607-3	2015	Shati/Nat8l produces N-acetylaspartate from aspartate and acetyl-CoA.	Aspartic Acid	29-38	N-acetyltransferase 8-like	Mus musculus	0-5
26164607-3	2015	Shati/Nat8l produces N-acetylaspartate from aspartate and acetyl-CoA.	Aspartic Acid	29-38	N-acetyltransferase 8-like	Mus musculus	6-11
26157044-7	2015	The exposure of DRG cultures to bradykinin (10 muM) and prostaglandin E2 (1 muM) increased the expression of calcitonin gene-related peptide (CGRP) and neuronal nitric oxide synthase in small- and medium-sized neurons as well as the levels of CGRP, aspartate, and glutamate in the cultured medium.	Aspartic Acid	249-258	calcitonin-related polypeptide alpha	Rattus norvegicus	109-140
26253719-3	2015	It was previously shown that substitutions at the catalytic residues, aspartate-142 position replaced to leucine-142 and tyrosine-185 position replaced to alanine-185 strongly reduces the PPIase activity of Mip proteins.	Aspartic Acid	70-79	major intrinsic protein of lens fiber	Homo sapiens	207-210
26157044-7	2015	The exposure of DRG cultures to bradykinin (10 muM) and prostaglandin E2 (1 muM) increased the expression of calcitonin gene-related peptide (CGRP) and neuronal nitric oxide synthase in small- and medium-sized neurons as well as the levels of CGRP, aspartate, and glutamate in the cultured medium.	Aspartic Acid	249-258	calcitonin-related polypeptide alpha	Rattus norvegicus	142-146
26170455-8	2015	Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain contribute to their differential binding abilities to polysaccharides isolated from Ganoderma lucidum (GLPS-F3).	Aspartic Acid	108-111	C-type lectin domain family 18 member A	Homo sapiens	10-16
26327616-7	2015	Data on inhibition of OCT2-mediated ASP+ uptake were obtained from previous literature.	Aspartic Acid	36-40	POU class 2 homeobox 2	Homo sapiens	22-26
26327616-8	2015	A moderate correlation between the inhibition of OCT2-mediated MPP+, ASP+, and metformin uptake was observed (pairwise rs between 0.27 and 0.48, all P &lt; 0.05).	Aspartic Acid	69-73	POU class 2 homeobox 2	Homo sapiens	49-53
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Aspartic Acid	63-66	serine protease 3	Homo sapiens	39-50
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Aspartic Acid	63-66	serine protease 3	Homo sapiens	152-163
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Aspartic Acid	63-66	spleen trypsin inhibitor I	Bos taurus	183-187
25809592-4	2015	The aspartate-glutamate exchanger Aralar/AGC1 (Slc25a12), a component of the malate-aspartate shuttle (MAS), is stimulated by modest increases in cytosolic Ca(2+) and upregulates respiration in cortical neurons by enhancing pyruvate supply into mitochondria.	Aspartic Acid	4-13	solute carrier family 25 member 12	Homo sapiens	47-55
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Aspartic Acid	63-66	amyloid beta precursor protein	Homo sapiens	192-196
25809592-4	2015	The aspartate-glutamate exchanger Aralar/AGC1 (Slc25a12), a component of the malate-aspartate shuttle (MAS), is stimulated by modest increases in cytosolic Ca(2+) and upregulates respiration in cortical neurons by enhancing pyruvate supply into mitochondria.	Aspartic Acid	4-13	solute carrier family 25 member 12	Homo sapiens	34-40
25809592-4	2015	The aspartate-glutamate exchanger Aralar/AGC1 (Slc25a12), a component of the malate-aspartate shuttle (MAS), is stimulated by modest increases in cytosolic Ca(2+) and upregulates respiration in cortical neurons by enhancing pyruvate supply into mitochondria.	Aspartic Acid	4-13	solute carrier family 25 member 12	Homo sapiens	41-45
26056729-11	2015	Moreover, the association of VF factor with 148 Asp/Glu of APE1 genotype distribution and POAG progression (OR 2.25; 95% CI 1.30-3.89) was also found.	Aspartic Acid	48-51	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	59-63
26330901-3	2015	Aralar/AGC1, a Ca(2+)-dependent aspartate-glutamate carrier on mitochondrial membrane, is a component of MAS.	Aspartic Acid	32-41	solute carrier family 25 member 12	Homo sapiens	0-6
26330901-3	2015	Aralar/AGC1, a Ca(2+)-dependent aspartate-glutamate carrier on mitochondrial membrane, is a component of MAS.	Aspartic Acid	32-41	solute carrier family 25 member 12	Homo sapiens	7-11
26249707-7	2015	There is a conserved aspartic acid residue in both structures, which has been shown to be important for hydration of the C=C bond during the release of unsaturated galacturonic acid by YteR.	Aspartic Acid	21-34	unsaturated rhamnogalacturonyl hydrolase	Bacillus subtilis subsp. subtilis str. 168	185-189
25641578-8	2015	We found that phosphorylation of Gln3 was impaired in all of these mutations and that the aspartic acid substitution mutants showed drastic reduction of Gln3-mediated transcriptional activity despite the fact that the mutations had no effect on nuclear localization of Gln3.	Aspartic Acid	90-103	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	153-157
25641578-8	2015	We found that phosphorylation of Gln3 was impaired in all of these mutations and that the aspartic acid substitution mutants showed drastic reduction of Gln3-mediated transcriptional activity despite the fact that the mutations had no effect on nuclear localization of Gln3.	Aspartic Acid	90-103	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	153-157
25891130-2	2015	ADAM15 is unique among the ADAMs in having an Arg-Gly-Asp motif in its disintegrin domain.	Aspartic Acid	54-57	ADAM metallopeptidase domain 15	Homo sapiens	0-6
26232224-5	2015	GOT1 normally consumes aspartate to transfer electrons into mitochondria, but, upon ETC inhibition, it reverses to generate aspartate in the cytosol, which partially compensates for the loss of mitochondrial aspartate synthesis.	Aspartic Acid	23-32	glutamic-oxaloacetic transaminase 1	Homo sapiens	0-4
26314441-5	2015	The time of PFS in CHOP group was 24.7 months, and the time of PFS in ASP+CHOP group was 47.5 months which was significantly longer than that in CHOP group, and there was statistical siguificance between these 2 groups (P &lt; 0.05).	Aspartic Acid	70-73	DNA damage inducible transcript 3	Homo sapiens	74-78
26314441-5	2015	The time of PFS in CHOP group was 24.7 months, and the time of PFS in ASP+CHOP group was 47.5 months which was significantly longer than that in CHOP group, and there was statistical siguificance between these 2 groups (P &lt; 0.05).	Aspartic Acid	70-73	DNA damage inducible transcript 3	Homo sapiens	74-78
26063505-4	2015	The increases of Asp, Lys, and Met in ak-hsdh2 were also observed in ak1-1, ak2-1, ak3-1, and ak-hsdh1-1.	Aspartic Acid	17-20	aspartate kinase 1	Arabidopsis thaliana	69-74
26232224-5	2015	GOT1 normally consumes aspartate to transfer electrons into mitochondria, but, upon ETC inhibition, it reverses to generate aspartate in the cytosol, which partially compensates for the loss of mitochondrial aspartate synthesis.	Aspartic Acid	124-133	glutamic-oxaloacetic transaminase 1	Homo sapiens	0-4
26232224-5	2015	GOT1 normally consumes aspartate to transfer electrons into mitochondria, but, upon ETC inhibition, it reverses to generate aspartate in the cytosol, which partially compensates for the loss of mitochondrial aspartate synthesis.	Aspartic Acid	124-133	glutamic-oxaloacetic transaminase 1	Homo sapiens	0-4
26232224-6	2015	Pyruvate stimulates aspartate synthesis in a GOT1-dependent fashion, which is required for pyruvate to rescue proliferation of cells with ETC dysfunction.	Aspartic Acid	20-29	glutamic-oxaloacetic transaminase 1	Homo sapiens	45-49
26049008-3	2015	To this aim, we focused on the chemokine 5 receptor (CCR5) expressed in human and mouse cortical glutamate terminals, whose activation by CCL5 elicits [(3)H]D-aspartate ([(3)H]D-ASP) release.	Aspartic Acid	159-168	C-C motif chemokine receptor 5	Homo sapiens	53-57
26085383-5	2015	The interaction of both mono- and dinuclear complexes with very similar dicarboxylates of biological interest (malate and aspartate) resulted in strikingly different outcomes: in the first case a ternary complex [ligand...metal...dicarboxylate] was obtained almost quantitatively, while in the latter, the Cu(ii) displacement to form Cu(Asp)2 was predominant.	Aspartic Acid	122-131	beta-secretase 1	Homo sapiens	334-342
26049008-3	2015	To this aim, we focused on the chemokine 5 receptor (CCR5) expressed in human and mouse cortical glutamate terminals, whose activation by CCL5 elicits [(3)H]D-aspartate ([(3)H]D-ASP) release.	Aspartic Acid	159-168	chemokine (C-C motif) ligand 5	Mus musculus	138-142
26049008-3	2015	To this aim, we focused on the chemokine 5 receptor (CCR5) expressed in human and mouse cortical glutamate terminals, whose activation by CCL5 elicits [(3)H]D-aspartate ([(3)H]D-ASP) release.	Aspartic Acid	178-181	C-C motif chemokine receptor 5	Homo sapiens	53-57
26049008-3	2015	To this aim, we focused on the chemokine 5 receptor (CCR5) expressed in human and mouse cortical glutamate terminals, whose activation by CCL5 elicits [(3)H]D-aspartate ([(3)H]D-ASP) release.	Aspartic Acid	178-181	chemokine (C-C motif) ligand 5	Mus musculus	138-142
26049008-4	2015	Preincubating synaptosomes with an antibody recognizing the NH2 terminus of the CCR5 protein (anti-NH2-CCR5 antibody) abolished the CCL5-induced [(3)H]D-ASP release.	Aspartic Acid	153-156	C-C motif chemokine receptor 5	Homo sapiens	80-84
26049008-4	2015	Preincubating synaptosomes with an antibody recognizing the NH2 terminus of the CCR5 protein (anti-NH2-CCR5 antibody) abolished the CCL5-induced [(3)H]D-ASP release.	Aspartic Acid	153-156	C-C motif chemokine receptor 5	Homo sapiens	103-107
26049008-4	2015	Preincubating synaptosomes with an antibody recognizing the NH2 terminus of the CCR5 protein (anti-NH2-CCR5 antibody) abolished the CCL5-induced [(3)H]D-ASP release.	Aspartic Acid	153-156	C-C motif chemokine ligand 5	Homo sapiens	132-136
26049008-5	2015	Similarly, enriching synaptosomes with an antibody recognizing the COOH terminus of CCR5 (anti-COOH-CCR5 antibody) prevented the CCL5-induced [(3)H]D-ASP release.	Aspartic Acid	150-153	C-C motif chemokine receptor 5	Homo sapiens	84-88
26049008-5	2015	Similarly, enriching synaptosomes with an antibody recognizing the COOH terminus of CCR5 (anti-COOH-CCR5 antibody) prevented the CCL5-induced [(3)H]D-ASP release.	Aspartic Acid	150-153	C-C motif chemokine receptor 5	Homo sapiens	100-104
26049008-5	2015	Similarly, enriching synaptosomes with an antibody recognizing the COOH terminus of CCR5 (anti-COOH-CCR5 antibody) prevented the CCL5-induced [(3)H]D-ASP release.	Aspartic Acid	150-153	C-C motif chemokine ligand 5	Homo sapiens	129-133
26049008-8	2015	On the contrary, the complement-induced [(3)H]D-ASP release from anti-COOH-CCR5 antibody-entrapped synaptosomes did not differ from that from untreated synaptosomes.	Aspartic Acid	48-51	C-C motif chemokine receptor 5	Homo sapiens	75-79
26049008-10	2015	Finally, serum lacking the C1q protein, i.e. the protein essential to promote the antibody-mediated activation of complement, elicited a comparable [(3)H]D-ASP release from both untreated and anti-NH2-CCR5 antibody-treated synaptosomes.	Aspartic Acid	156-159	complement C1q A chain	Homo sapiens	27-30
26132391-6	2015	Exposure to ET-1 for 24 h increased the ASP+ uptake significantly (20 +- 5%, p &lt; 0.001).	Aspartic Acid	40-44	endothelin 1	Homo sapiens	12-16
25912234-8	2015	Moreover, when T34 was mutated to aspartic acid (T34D) to mimic its phosphorylation, Akt-membrane association assessed by surface plasmon resonance spectroscopy was significantly reduced.	Aspartic Acid	34-47	AKT serine/threonine kinase 1	Homo sapiens	85-88
25805806-1	2015	Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.	Aspartic Acid	194-197	phospholipase A2, group IB, pancreas	Mus musculus	34-50
25805806-1	2015	Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.	Aspartic Acid	194-197	phospholipase A2, group IB, pancreas	Mus musculus	52-56
25805806-1	2015	Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.	Aspartic Acid	194-197	phospholipase A2, group IB, pancreas	Mus musculus	80-84
25805806-1	2015	Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca(2+)-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.	Aspartic Acid	194-197	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	86-91
25910650-5	2015	Two aspartic acid residues, which are both essential for the yeast PGPP (Gep4p) activity, are also conserved in the putative catalytic motif of CrPGPP1.	Aspartic Acid	4-17	phosphatidylglycerophosphatase	Saccharomyces cerevisiae S288C	73-78
25957474-6	2015	In this study, we report that an HLD4-associated (Asp-29-to-Gly) mutant of mitochondrial heat shock 60-kDa protein 1 (HSPD1) causes short-length morphologies and increases the numbers of mitochondria due to their aberrant fission and fusion cycles.	Aspartic Acid	50-53	heat shock protein family D (Hsp60) member 1	Homo sapiens	33-37
25957474-6	2015	In this study, we report that an HLD4-associated (Asp-29-to-Gly) mutant of mitochondrial heat shock 60-kDa protein 1 (HSPD1) causes short-length morphologies and increases the numbers of mitochondria due to their aberrant fission and fusion cycles.	Aspartic Acid	50-53	heat shock protein family D (Hsp60) member 1	Homo sapiens	118-123
25839357-4	2015	The recent observation that aspartate in position 69 (D69) is determinant for the formation of NMO-IgG epitopes prompted us to carry out intensive Molecular Dynamics (MD) studies on a number of single-point AQP4 mutants.	Aspartic Acid	28-37	aquaporin 4	Homo sapiens	207-211
26081605-3	2015	The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.	Aspartic Acid	38-41	fibronectin 1	Mus musculus	123-134
26114427-13	2015	Moreover, our metabolomics data showing the activation of the purine nucleotide pathway, malate-aspartate shuttle, as well as creatine metabolism, which are known to be active during exercise, further suggests that PGC-1alpha regulates metabolism in exercise.	Aspartic Acid	96-105	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	215-225
25950869-0	2015	Highly Amino Acid Selective Hydrolysis of Myoglobin at Aspartate Residues as Promoted by Zirconium(IV)-Substituted Polyoxometalates.	Aspartic Acid	55-64	myoglobin	Homo sapiens	42-51
26098225-5	2015	RGD (arginine-glycine-aspartic acid), which is an integrin-binding domain of fibronectin, has been found to enhance cell adhesion and survival; it has been used to modify substrates for in vitro cell culture studies or used as tissue engineering scaffolds.	Aspartic Acid	22-35	fibronectin 1	Homo sapiens	77-88
26020686-8	2015	(4) Yeast beta1 and human beta1c subunits preferentially bind Asp and Leu in their S1 pockets, while Glu and large hydrophobic residues are not accepted.	Aspartic Acid	62-65	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	10-15
26240838-5	2015	Specifically, compared with undecorated gels, those functionalized with Arg-Gly-Asp-Ser (RGDS) peptides increase the proliferative activity of NSCs; promote their directional migration; induce differentiation, with increased expression of microtubule-associated protein-2, and a low expression of glial fibrillary acidic protein; and lead to the formation of larger neurospheres.	Aspartic Acid	80-83	ral guanine nucleotide dissociation stimulator	Mus musculus	89-93
27462411-3	2015	Consistently, a 30% reduced charging level of tRNA-Asp was observed in Dnmt2 knockout (KO) murine embryonic fibroblast cells.	Aspartic Acid	51-54	tRNA aspartic acid methyltransferase 1	Mus musculus	71-76
27462411-5	2015	The same effect was observed with endogenous proteins containing poly-Asp sequences, indicating that Dnmt2-mediated C38 methylation of tRNA-Asp regulates the translation of proteins containing poly-Asp sequences.	Aspartic Acid	70-73	tRNA aspartic acid methyltransferase 1	Mus musculus	101-106
27462411-5	2015	The same effect was observed with endogenous proteins containing poly-Asp sequences, indicating that Dnmt2-mediated C38 methylation of tRNA-Asp regulates the translation of proteins containing poly-Asp sequences.	Aspartic Acid	140-143	tRNA aspartic acid methyltransferase 1	Mus musculus	101-106
26240838-5	2015	Specifically, compared with undecorated gels, those functionalized with Arg-Gly-Asp-Ser (RGDS) peptides increase the proliferative activity of NSCs; promote their directional migration; induce differentiation, with increased expression of microtubule-associated protein-2, and a low expression of glial fibrillary acidic protein; and lead to the formation of larger neurospheres.	Aspartic Acid	80-83	microtubule-associated protein 2	Mus musculus	239-271
25753114-3	2015	In particular, in a patient with severe early-onset obesity, a novel heterozygous mutation in the MC4R gene was found in an exchange of Asp to Asn in the 90th amino acid residue located in the TM 2 domain (MC4RD90N).	Aspartic Acid	136-139	melanocortin 4 receptor	Homo sapiens	98-102
25903137-9	2015	Thus, a single Asp residue can account for the sensitivity of Slo2.1 channels to intracellular Na(+).	Aspartic Acid	15-18	potassium sodium-activated channel subfamily T member 2	Homo sapiens	62-68
25921325-1	2015	The solute carrier family 25 (aspartate/glutamate carrier), member 12 gene (SLC25A12) has been strongly posed as a candidate gene for autism spectrum disorder (ASD) given its important role in mitochondrial function and adenosine triphosphate (ATP) synthesis.	Aspartic Acid	30-39	solute carrier family 25 member 12	Homo sapiens	76-84
26083951-0	2015	Integrin alphavbeta3 as a Promising Target to Image Neoangiogenesis Using In-House Generator-Produced Positron Emitter (68)Ga-Labeled DOTA-Arginine-Glycine-Aspartic Acid (RGD) Ligand.	Aspartic Acid	156-169	integrin subunit alpha V	Homo sapiens	0-20
25818421-4	2015	Considering that the eight repeating sequences of aspartate (D-Asp8) could preferably bind to highly crystallized hydroxyapatite, we developed a targeting system by conjugating D-Asp8 peptide with liposome for delivering microRNA modulators specifically to bone resorption surfaces and subsequently encapsulated antagomir-148a (a microRNA modulator suppressing the osteoclastogenic miR-148a), i.e. (D-Asp8)-liposome-antagomir-148a.	Aspartic Acid	50-59	microRNA 148a	Mus musculus	382-390
26062589-1	2015	Citrin, encoded by SLC25A13, is a component of the malate-aspartate shuttle, which is the main NADH-transporting system in the liver.	Aspartic Acid	58-67	solute carrier family 25 member 13	Homo sapiens	0-6
26062589-1	2015	Citrin, encoded by SLC25A13, is a component of the malate-aspartate shuttle, which is the main NADH-transporting system in the liver.	Aspartic Acid	58-67	solute carrier family 25 member 13	Homo sapiens	19-27
25867020-0	2015	Aspartate-modified doxorubicin on its N-terminal increases drug accumulation in LAT1-overexpressing tumors.	Aspartic Acid	0-9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	80-84
25867020-4	2015	The aspartate-modified doxorubicin (Asp-DOX) showed the highest affinity (Km = 41.423 mumol/L) to LAT1.	Aspartic Acid	4-13	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	98-102
25052542-6	2015	Asp supplementation increased the mRNA expression of key enzymes in hepatic glycolysis and tricarboxylic acid (TCA) cycle, including pyruvate kinase and citrate synthase (p &lt; 0.05), and had a tendency to increase hepatic pyruvate dehydrogenase and isocitrate dehydrogenase beta mRNA expression (p &lt; 0.10).	Aspartic Acid	0-3	citrate synthase	Sus scrofa	153-169
25651041-7	2015	RESULTS: We discovered a significant increase in the frequency of binucleated lymphocytes with micronuclei (MN) in carriers of the His/His genotype of the XpG gene Asp1104His polymorphism in comparison to heterozygous and homozygous carriers of the Asp allele.	Aspartic Acid	164-167	ERCC excision repair 5, endonuclease	Homo sapiens	155-158
25052542-7	2015	In addition, Asp increased the mRNA expressions of hepatic AMP-activated protein kinase (AMPK) alpha1, AMPKalpha2, silent information regulator (Sirt1), and proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha) (p &lt; 0.05).	Aspartic Acid	13-16	sirtuin 1	Sus scrofa	145-150
25052542-7	2015	In addition, Asp increased the mRNA expressions of hepatic AMP-activated protein kinase (AMPK) alpha1, AMPKalpha2, silent information regulator (Sirt1), and proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha) (p &lt; 0.05).	Aspartic Acid	13-16	PPARG coactivator 1 alpha	Sus scrofa	215-224
25945972-6	2015	Furthermore, we also identified an Arg-Asp/Glu-Glu-Arg salt-bridge network and the corresponding loop (to position the second Asp/Glu residue) critical for the LN1/2-binding preference.	Aspartic Acid	39-42	phytanoyl-CoA 2-hydroxylase	Homo sapiens	160-163
25940820-2	2015	Firstly at nucleotide 255 where C   T (codon 60 GAC   GAT), resulting in a non-coding change as GAC and GAT both code for the same amino acid aspartic acid.	Aspartic Acid	142-155	glycine-N-acyltransferase	Homo sapiens	54-57
25940820-2	2015	Firstly at nucleotide 255 where C   T (codon 60 GAC   GAT), resulting in a non-coding change as GAC and GAT both code for the same amino acid aspartic acid.	Aspartic Acid	142-155	glycine-N-acyltransferase	Homo sapiens	104-107
25849526-6	2015	By replacing the valine in the second position with aspartic acid, the resulting Neuropep-4 was found to be highly effective in inducing BDNF expression even at concentrations of 1pM in the SH-SY5Y cell line and rat primary cortical neurons.	Aspartic Acid	52-65	brain derived neurotrophic factor	Homo sapiens	137-141
25918421-8	2015	TM6 and TM7 in PS1, which harbor the catalytic aspartate residues, are located on the convex side of the TM horseshoe.	Aspartic Acid	47-56	presenilin 1	Homo sapiens	15-18
25955978-3	2015	The selectivity of the open HV1 channel requires an aspartate near an arginine in the selectivity filter (SF), a narrow region that dictates proton selectivity, but the mechanism of proton selectivity is unknown.	Aspartic Acid	52-61	hydrogen voltage gated channel 1	Homo sapiens	28-31
25817565-6	2015	The same effect is observed when the corresponding conserved Asp (D105) was mutated in MYC2.	Aspartic Acid	61-64	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	87-91
25745109-7	2015	Two adjacent acidic amino acids in this region (Asp-546 and Glu-547) are important for both the RAG1-RAG2 interaction and recombination activity, with Asp-546 of particular importance.	Aspartic Acid	48-51	recombination activating 1	Mus musculus	96-100
25745109-7	2015	Two adjacent acidic amino acids in this region (Asp-546 and Glu-547) are important for both the RAG1-RAG2 interaction and recombination activity, with Asp-546 of particular importance.	Aspartic Acid	48-51	recombination activating gene 2	Mus musculus	101-105
25745109-7	2015	Two adjacent acidic amino acids in this region (Asp-546 and Glu-547) are important for both the RAG1-RAG2 interaction and recombination activity, with Asp-546 of particular importance.	Aspartic Acid	151-154	recombination activating 1	Mus musculus	96-100
25745109-7	2015	Two adjacent acidic amino acids in this region (Asp-546 and Glu-547) are important for both the RAG1-RAG2 interaction and recombination activity, with Asp-546 of particular importance.	Aspartic Acid	151-154	recombination activating gene 2	Mus musculus	101-105
25745109-8	2015	Structural modeling of Mini-RAG1 suggests that Asp-546/Glu-547 lie near the predicted 997-1008 alpha-helix and components of the active site, raising the possibility that RAG2 binding alters the structure of the RAG1 active site.	Aspartic Acid	47-50	recombination activating 1	Mus musculus	28-32
25745109-8	2015	Structural modeling of Mini-RAG1 suggests that Asp-546/Glu-547 lie near the predicted 997-1008 alpha-helix and components of the active site, raising the possibility that RAG2 binding alters the structure of the RAG1 active site.	Aspartic Acid	47-50	recombination activating gene 2	Mus musculus	171-175
25745109-8	2015	Structural modeling of Mini-RAG1 suggests that Asp-546/Glu-547 lie near the predicted 997-1008 alpha-helix and components of the active site, raising the possibility that RAG2 binding alters the structure of the RAG1 active site.	Aspartic Acid	47-50	recombination activating 1	Mus musculus	212-216
25945972-6	2015	Furthermore, we also identified an Arg-Asp/Glu-Glu-Arg salt-bridge network and the corresponding loop (to position the second Asp/Glu residue) critical for the LN1/2-binding preference.	Aspartic Acid	126-129	phytanoyl-CoA 2-hydroxylase	Homo sapiens	160-163
25595659-7	2015	Notably, Pin1 with Cys113 substituted by aspartic acid retains activity and is no longer sensitive to oxidation.	Aspartic Acid	41-54	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	9-13
25945586-1	2015	Homoserine dehydrogenase (HSD) is an oxidoreductase in the aspartic acid pathway.	Aspartic Acid	59-72	AT695_RS10950	Staphylococcus aureus	0-24
25945586-1	2015	Homoserine dehydrogenase (HSD) is an oxidoreductase in the aspartic acid pathway.	Aspartic Acid	59-72	AT695_RS10950	Staphylococcus aureus	26-29
25945586-1	2015	Homoserine dehydrogenase (HSD) is an oxidoreductase in the aspartic acid pathway.	Aspartic Acid	59-72	AT695_RS02795	Staphylococcus aureus	37-51
25646960-2	2015	Biosynthesis of D-Asp has been observed in several cultured rat cell lines, and a murine gene (glutamate-oxaloacetate transaminase 1-like 1, Got1l1) that encodes Asp racemase, a synthetic enzyme that produces D-Asp from L-Asp, was proposed recently.	Aspartic Acid	18-21	glutamic-oxaloacetic transaminase 1-like 1	Mus musculus	141-147
25646960-2	2015	Biosynthesis of D-Asp has been observed in several cultured rat cell lines, and a murine gene (glutamate-oxaloacetate transaminase 1-like 1, Got1l1) that encodes Asp racemase, a synthetic enzyme that produces D-Asp from L-Asp, was proposed recently.	Aspartic Acid	220-225	glutamic-oxaloacetic transaminase 1-like 1	Mus musculus	141-147
25646960-4	2015	Here, we tested the hypothesis that rat and human homologs of mouse GOT1L1 are involved in Asp synthesis.	Aspartic Acid	91-94	glutamic-oxaloacetic transaminase 1-like 1	Mus musculus	68-74
25646960-7	2015	Second, the effect of knockdown of the Got1l1 gene on D-Asp biosynthesis during culture of the cells was determined.	Aspartic Acid	56-59	glutamic-oxaloacetic transaminase 1 like 1	Homo sapiens	39-45
24293383-3	2015	The single oral dose of CCl4 (2 mL/kg) caused a significant elevation in serum aspartate and alanine aminotransferase activities, which decreased upon pretreatment with DADS.	Aspartic Acid	79-88	C-C motif chemokine ligand 4	Rattus norvegicus	24-28
25740311-2	2015	EML1-4 consist of Trp-Asp 40 (WD40) repeats and an N-terminal region containing a putative coiled-coil.	Aspartic Acid	22-25	EMAP like 1	Homo sapiens	0-4
25747896-2	2015	The DNMT2 protein methylates C38 of tRNA-Asp and it has a role in cellular physiology and stress response and its expression levels are altered in cancer tissues.	Aspartic Acid	41-44	tRNA aspartic acid methyltransferase 1	Homo sapiens	4-9
25596185-5	2015	hETHE1 contains an alphabetabetaalpha MBL-fold, which supports metal-binding by the side chains of an aspartate and two histidine residues; three water molecules complete octahedral coordination of the iron.	Aspartic Acid	102-111	ETHE1 persulfide dioxygenase	Homo sapiens	0-6
25596185-7	2015	The histidine and aspartate residues involved in iron-binding in ETHE1, occupy similar positions to those observed across both the zinc 1 and zinc 2 binding sites in classical MBLs.	Aspartic Acid	18-27	ETHE1 persulfide dioxygenase	Homo sapiens	65-70
25713081-7	2015	In contrast, mutation of Asp-219 abrogated the anti-apoptotic activity of GAAP but not its effects on cell migration and adhesion.	Aspartic Acid	25-28	transmembrane BAX inhibitor motif containing 4	Homo sapiens	74-78
25860111-6	2015	In conclusion, curcumin and PCI-34058-mediated ligand-dependent HDAC1 tunnel closure interferes negatively with the ASP-HIS charge relay system in HDAC1.	Aspartic Acid	116-119	histone deacetylase 1	Homo sapiens	64-69
25792737-5	2015	Substitution of Thr-148 for a phospho-mimicking aspartate (T148D) prevents AMPK from binding to carbohydrate.	Aspartic Acid	48-57	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	75-79
25860111-6	2015	In conclusion, curcumin and PCI-34058-mediated ligand-dependent HDAC1 tunnel closure interferes negatively with the ASP-HIS charge relay system in HDAC1.	Aspartic Acid	116-119	histone deacetylase 1	Homo sapiens	147-152
24249517-0	2015	Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.	Aspartic Acid	119-122	secreted phosphoprotein 1	Mus musculus	0-11
25648277-6	2015	The END assay, measurements of induced type I interferon and IRF-3 detection in cells infected with these viruses revealed that the aspartic acid at position 136 in the zinc-binding TRASH motif of N(pro) was required to inhibit the production of type I interferon via the degradation of cellular IRF-3, consistently with CSFV.	Aspartic Acid	132-145	interferon regulatory factor 3	Homo sapiens	39-66
25648277-6	2015	The END assay, measurements of induced type I interferon and IRF-3 detection in cells infected with these viruses revealed that the aspartic acid at position 136 in the zinc-binding TRASH motif of N(pro) was required to inhibit the production of type I interferon via the degradation of cellular IRF-3, consistently with CSFV.	Aspartic Acid	132-145	interferon regulatory factor 3	Homo sapiens	61-66
25660763-8	2015	The lysis time of clots made from purified fibrinogen of AAA-Asp was longer than that of AAA+Asp patients (756 +- 47 and 592 +- 52 s, respectively; P = 0.041).	Aspartic Acid	61-64	fibrinogen beta chain	Homo sapiens	43-53
24249517-0	2015	Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.	Aspartic Acid	119-122	caspase 8	Homo sapiens	155-164
25800379-5	2015	Hydrogen-bonding network analyses suggest that the elimination of the hydrogen bond between the linker ether and aspartate 321 (D321) of human trehalase is the key for lactulose and melibiose to avoid the hydrolyzation.	Aspartic Acid	113-122	trehalase	Homo sapiens	143-152
25909857-4	2015	The results of this study showed that aspartic acid attenuated the UVA-induced reduction of the proliferative potential and stemness of hAMSCs, as evidenced by increased proliferative activity in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and upregulation of stemness-related genes OCT4, NANOG, and SOX2 in response to the aspartic acid treatment.	Aspartic Acid	38-51	POU class 5 homeobox 1	Homo sapiens	316-320
25909857-4	2015	The results of this study showed that aspartic acid attenuated the UVA-induced reduction of the proliferative potential and stemness of hAMSCs, as evidenced by increased proliferative activity in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and upregulation of stemness-related genes OCT4, NANOG, and SOX2 in response to the aspartic acid treatment.	Aspartic Acid	38-51	Nanog homeobox	Homo sapiens	322-327
25909857-4	2015	The results of this study showed that aspartic acid attenuated the UVA-induced reduction of the proliferative potential and stemness of hAMSCs, as evidenced by increased proliferative activity in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and upregulation of stemness-related genes OCT4, NANOG, and SOX2 in response to the aspartic acid treatment.	Aspartic Acid	38-51	SRY-box transcription factor 2	Homo sapiens	333-337
25909857-5	2015	UVA-induced reduction in the mRNA level of hypoxia-inducible factor (HIF)-1alpha was also significantly recovered by aspartic acid.	Aspartic Acid	117-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-80
25909857-6	2015	In addition, the antagonizing effects of aspartic acid against the UVA effects were found to be mediated by reduced production of PGE2 through the inhibition of JNK and p42/44 MAPK.	Aspartic Acid	41-54	mitogen-activated protein kinase 8	Homo sapiens	161-164
25909857-6	2015	In addition, the antagonizing effects of aspartic acid against the UVA effects were found to be mediated by reduced production of PGE2 through the inhibition of JNK and p42/44 MAPK.	Aspartic Acid	41-54	erythrocyte membrane protein band 4.2	Homo sapiens	169-172
25909857-7	2015	Taken together, these findings show that aspartic acid improves reduced stemness of hAMSCs induced by UVA and its effects are mediated by upregulation of HIF-1alpha via the inhibition of PGE2-cAMP signaling.	Aspartic Acid	41-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-164
25728925-5	2015	We identified that Glu instead of Asp in the WPE loop contributes to the catalytic incapability of PTPN21 due to an extended distance beyond protonation targeting a phosphotyrosine substrate.	Aspartic Acid	34-37	protein tyrosine phosphatase non-receptor type 21	Homo sapiens	99-105
25755250-0	2015	SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.	Aspartic Acid	59-68	sirtuin 3	Homo sapiens	0-5
25755250-0	2015	SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.	Aspartic Acid	59-68	glutamic-oxaloacetic transaminase 2	Homo sapiens	16-20
25755250-9	2015	Our study uncovers a previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection.	Aspartic Acid	98-107	glutamic-oxaloacetic transaminase 2	Homo sapiens	59-63
25579773-5	2015	This variant Hb is called Hb Watts [alpha2 74(EF3)Asp-&gt;0 or alpha2 75(EF4)Asp-&gt;0; HBA2:c.226_228delGAC].	Aspartic Acid	77-80	GTP binding elongation factor GUF1	Homo sapiens	73-76
25825730-4	2015	Genetic and biochemical evidence points to a "power stroke" mechanism in which the ions interact with an aspartate residue of MotB to drive conformational changes in MotA that are transmitted to the rotor protein FliG.	Aspartic Acid	105-114	FRAS1 related extracellular matrix 1	Homo sapiens	166-170
25830893-5	2015	CPT1A silencing reduced these processes and depleted endothelial cell stores of aspartate and deoxyribonucleoside triphosphates.	Aspartic Acid	80-89	carnitine palmitoyltransferase 1a, liver	Mus musculus	0-5
25587118-3	2015	We have identified a novel ClC-5 binding partner, cytosolic aspartyl aminopeptidase (DNPEP; EC 3.4.11.21), that catalyzes the release of N-terminal aspartate/glutamate residues.	Aspartic Acid	148-157	chloride voltage-gated channel 5	Rattus norvegicus	27-32
25587118-3	2015	We have identified a novel ClC-5 binding partner, cytosolic aspartyl aminopeptidase (DNPEP; EC 3.4.11.21), that catalyzes the release of N-terminal aspartate/glutamate residues.	Aspartic Acid	148-157	aspartyl aminopeptidase	Rattus norvegicus	85-90
25580908-2	2015	Recently, the following variations in the peptide-binding grooves of HLA molecules that predispose to RA development have been identified: Val and Leu at HLA-DRB1 position 11, Asp at HLA-B position 9, and Phe at HLA-DPB1 position 9.	Aspartic Acid	176-179	major histocompatibility complex, class II, DR beta 1	Homo sapiens	69-72
25342221-5	2015	By utilizing structure-based interaction models, mutagenesis and assays of cCPE-binding to the TJ-free cell line HEK293, transfected with human Cld1 and murine Cld5, we showed how cCPE-binding to Cld1 and Cld5 is prevented by two residues in extracellular loop 2 of Cld1 (Asn(150) and Thr(153)) and Cld5 (Asp(149) and Thr(151)).	Aspartic Acid	305-308	claudin 1	Homo sapiens	196-200
25581752-0	2015	Aspartate 496 from the subsite S2 drives specificity of human dipeptidyl peptidase III.	Aspartic Acid	0-9	dipeptidyl peptidase 3	Homo sapiens	62-86
25425280-4	2015	EXPERIMENTAL APPROACH: Molecular modelling of CXCR3, followed by virtual ligand docking, highlighted several CXCR3 residues likely to contact either antagonist, notably a conserved aspartate in helix 2 (Asp-112(2:63) ), which was postulated to interact with the quaternary nitrogen of TAK-779.	Aspartic Acid	181-190	C-X-C motif chemokine receptor 3	Homo sapiens	46-51
25425280-4	2015	EXPERIMENTAL APPROACH: Molecular modelling of CXCR3, followed by virtual ligand docking, highlighted several CXCR3 residues likely to contact either antagonist, notably a conserved aspartate in helix 2 (Asp-112(2:63) ), which was postulated to interact with the quaternary nitrogen of TAK-779.	Aspartic Acid	203-206	C-X-C motif chemokine receptor 3	Homo sapiens	46-51
25425280-4	2015	EXPERIMENTAL APPROACH: Molecular modelling of CXCR3, followed by virtual ligand docking, highlighted several CXCR3 residues likely to contact either antagonist, notably a conserved aspartate in helix 2 (Asp-112(2:63) ), which was postulated to interact with the quaternary nitrogen of TAK-779.	Aspartic Acid	203-206	C-X-C motif chemokine receptor 3	Homo sapiens	109-114
25342221-5	2015	By utilizing structure-based interaction models, mutagenesis and assays of cCPE-binding to the TJ-free cell line HEK293, transfected with human Cld1 and murine Cld5, we showed how cCPE-binding to Cld1 and Cld5 is prevented by two residues in extracellular loop 2 of Cld1 (Asn(150) and Thr(153)) and Cld5 (Asp(149) and Thr(151)).	Aspartic Acid	305-308	claudin 1	Homo sapiens	196-200
25637053-7	2015	Accordingly, the shedding of the transferrin receptor-2 variant G679A, mutated in the Arginine-Glycine-Aspartic acid motif and unable to bind diferric transferrin, is not modulated by the ligand.	Aspartic Acid	103-116	transferrin receptor 2	Homo sapiens	33-55
26118131-5	2015	This modification is a rapid and simple approach to investigate the role of aspartate and glutamate residues in the structure, function and folding of CAT.	Aspartic Acid	76-85	catalase	Homo sapiens	151-154
25751738-10	2015	A nearby aspartic acid residue side-chain transiently stores protons required for the reaction, which is crucial for NPs" function as nitrite dismutase.	Aspartic Acid	9-22	neuropeptide S	Homo sapiens	117-121
25577037-0	2015	Dual receptor-targeting 99mTc-labeled Arg-Gly-Asp-conjugated Alpha-Melanocyte stimulating hormone hybrid peptides for human melanoma imaging.	Aspartic Acid	46-49	proopiomelanocortin	Homo sapiens	61-97
25483709-2	2015	Another study indicated that ANP32B was a direct substrate of caspase-3, and was primarily cleaved at the sequence Ala-Glu-Val-Asp, following Asp-163.	Aspartic Acid	127-130	acidic nuclear phosphoprotein 32 family member B	Homo sapiens	29-35
25483709-2	2015	Another study indicated that ANP32B was a direct substrate of caspase-3, and was primarily cleaved at the sequence Ala-Glu-Val-Asp, following Asp-163.	Aspartic Acid	142-145	acidic nuclear phosphoprotein 32 family member B	Homo sapiens	29-35
25058375-3	2015	Involvement of the integrin was further shown by two disintegrins, Arg-Gly-Asp (RGD) and echistatin peptides, which occluded the effects of T3/T4 on viability, proliferating cell nuclear antigen (PCNA) (proliferation marker) and apoptotic gene expression.	Aspartic Acid	75-78	proliferating cell nuclear antigen	Mus musculus	160-194
25058375-3	2015	Involvement of the integrin was further shown by two disintegrins, Arg-Gly-Asp (RGD) and echistatin peptides, which occluded the effects of T3/T4 on viability, proliferating cell nuclear antigen (PCNA) (proliferation marker) and apoptotic gene expression.	Aspartic Acid	75-78	proliferating cell nuclear antigen	Mus musculus	196-200
25451601-4	2015	We show that SLC38A8 has preference for transporting L-glutamine, L-alanine, L-arginine, L-histidine and L-aspartate using a Na+-dependent transport mechanism and that the functional characteristics of SNAT8 have highest similarity to the known System A transporters.	Aspartic Acid	105-116	solute carrier family 38, member 8	Mus musculus	13-20
25853023-4	2015	Guiding this development, we describe how a fluorescent substrate for hNET, 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP(+)), can be used to optimise vector design and serve as an in vitro functional screen.	Aspartic Acid	124-130	solute carrier family 6 member 2	Homo sapiens	70-74
25853023-8	2015	hNET function was assessed using ASP(+)-guided flow cytometry.	Aspartic Acid	33-36	solute carrier family 6 member 2	Homo sapiens	0-4
25670858-6	2015	Conversely, mutation of the nine sites to phospho-mimicking Asp/Glu (9D/E) residues dissociated CENP-Q from chromatin and kept the CENP-Q(9D/E) mutant from localizing to interphase prekinetochores.	Aspartic Acid	60-63	centromere protein Q	Homo sapiens	96-102
25853023-10	2015	RESULTS: SupT1/FLuc.2A.RQR8.2A.hNET cells resulted in &gt;4-fold higher ASP(+) uptake compared to SupT1/hNET.2A.FLuc.2A.RQR8, suggesting that 2A orientation effected hNET function.	Aspartic Acid	72-75	solute carrier family 6 member 2	Homo sapiens	31-35
25853023-10	2015	RESULTS: SupT1/FLuc.2A.RQR8.2A.hNET cells resulted in &gt;4-fold higher ASP(+) uptake compared to SupT1/hNET.2A.FLuc.2A.RQR8, suggesting that 2A orientation effected hNET function.	Aspartic Acid	72-75	solute carrier family 6 member 2	Homo sapiens	104-108
25853023-10	2015	RESULTS: SupT1/FLuc.2A.RQR8.2A.hNET cells resulted in &gt;4-fold higher ASP(+) uptake compared to SupT1/hNET.2A.FLuc.2A.RQR8, suggesting that 2A orientation effected hNET function.	Aspartic Acid	72-75	solute carrier family 6 member 2	Homo sapiens	104-108
25659431-3	2015	In this study, we established M. tuberculosis NarL/NarS as a functional two-component system and identified His(241) and Asp(61) as conserved phosphorylation sites in NarS and NarL, respectively.	Aspartic Acid	121-124	nitrate/nitrite response transcriptional regulator NarL	Mycobacterium tuberculosis H37Rv	46-50
25670858-6	2015	Conversely, mutation of the nine sites to phospho-mimicking Asp/Glu (9D/E) residues dissociated CENP-Q from chromatin and kept the CENP-Q(9D/E) mutant from localizing to interphase prekinetochores.	Aspartic Acid	60-63	centromere protein Q	Homo sapiens	131-137
25568136-7	2015	Both ANG-(1-7) and its endogenous analog [Ala(1)]-ANG-(1-7) (alamandine) were preferentially hydrolyzed by the peptidase compared with ANG II, [Asp(1)]-ANG II, ANG I, and ANG-(1-12).	Aspartic Acid	144-147	angiopoietin 1	Homo sapiens	5-13
25751413-1	2015	Mutational analysis of Sulfolobus solfataricus class II alpha-mannosidase was focused on side chains that interact with the hydroxyls of the -1 mannosyl of the substrate (Asp-534) or form ligands to the active site divalent metal ion (His-228 and His-533) judged from crystal structures of homologous enzymes.	Aspartic Acid	171-174	SDR family oxidoreductase	Saccharolobus solfataricus	56-73
25614623-0	2015	Comparisons with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin.	Aspartic Acid	40-49	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	112-117
25614623-5	2015	Asp(25) and Lys(30) of medin align with residues Asp(23) and Lys(28) of Abeta, which are known to form a stabilizing salt bridge in some fibril morphologies.	Aspartic Acid	0-3	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	23-28
25614623-5	2015	Asp(25) and Lys(30) of medin align with residues Asp(23) and Lys(28) of Abeta, which are known to form a stabilizing salt bridge in some fibril morphologies.	Aspartic Acid	49-52	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	23-28
25614623-6	2015	Here we show that substituting Asp(25) of medin with asparagine (D25N) impedes assembly into fibrils and stabilizes non-cytotoxic oligomers.	Aspartic Acid	31-34	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	42-47
25614623-7	2015	Wild-type medin, by contrast, aggregates into beta-sheet-rich amyloid-like fibrils within 50 h. A structural analysis of wild-type fibrils by solid-state NMR suggests a molecular repeat unit comprising at least two extended beta-strands, separated by a turn stabilized by a Asp(25)-Lys(30) salt bridge.	Aspartic Acid	274-277	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	10-15
25614623-8	2015	We propose that Asp(25) drives the assembly of medin by stabilizing the fibrillar conformation of the peptide and is thus reminiscent of the influence of Asp(23) on the aggregation of Abeta.	Aspartic Acid	16-19	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	47-52
25614623-8	2015	We propose that Asp(25) drives the assembly of medin by stabilizing the fibrillar conformation of the peptide and is thus reminiscent of the influence of Asp(23) on the aggregation of Abeta.	Aspartic Acid	154-157	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	47-52
25568136-7	2015	Both ANG-(1-7) and its endogenous analog [Ala(1)]-ANG-(1-7) (alamandine) were preferentially hydrolyzed by the peptidase compared with ANG II, [Asp(1)]-ANG II, ANG I, and ANG-(1-12).	Aspartic Acid	144-147	angiopoietin 1	Homo sapiens	50-58
25595600-14	2015	In DISC1-immunized NHE rats, horizontal activity in Lat maze correlated with membrane-trapped glutamate in PFc and in the NRB rats, duration of rearing in Olton maze correlated with membrane-trapped glutamate in PFc and aspartate in dorsal striatum.	Aspartic Acid	220-229	DISC1 scaffold protein	Rattus norvegicus	3-8
25609249-8	2015	Access to a conserved catalytic triad consisting of Cys(101), His(264), and Asp(275) is regulated by the flexible BL2.	Aspartic Acid	76-79	cell adhesion molecule 1	Homo sapiens	114-117
25564618-1	2015	ADAMDEC1 is a proteolytically active metzincin metalloprotease displaying rare active site architecture with a zinc-binding Asp residue (Asp-362).	Aspartic Acid	124-127	ADAM like decysin 1	Homo sapiens	0-8
25564618-1	2015	ADAMDEC1 is a proteolytically active metzincin metalloprotease displaying rare active site architecture with a zinc-binding Asp residue (Asp-362).	Aspartic Acid	137-140	ADAM like decysin 1	Homo sapiens	0-8
25533124-1	2015	SLC25A13 (citrin or aspartate-glutamate carrier 2) is located in the mitochondrial membrane in the liver and its genetic deficiency causes adult-onset type II citrullinemia (CTLN2).	Aspartic Acid	20-29	solute carrier family 25 member 13	Homo sapiens	0-8
25533124-1	2015	SLC25A13 (citrin or aspartate-glutamate carrier 2) is located in the mitochondrial membrane in the liver and its genetic deficiency causes adult-onset type II citrullinemia (CTLN2).	Aspartic Acid	20-29	solute carrier family 25 member 13	Homo sapiens	10-16
25533124-1	2015	SLC25A13 (citrin or aspartate-glutamate carrier 2) is located in the mitochondrial membrane in the liver and its genetic deficiency causes adult-onset type II citrullinemia (CTLN2).	Aspartic Acid	20-29	solute carrier family 25 member 13	Homo sapiens	174-179
25723520-6	2015	The T7 residue of CDC26 is critical for its interaction with APC6, a tetratricopeptide repeat-containing subunit of APC/C, and mutation of this residue to Asp (T7D) reduced the interaction of CDC26 with APC6.	Aspartic Acid	155-158	cell division cycle 26	Homo sapiens	18-23
25947987-1	2015	Citrin deficiency is an autosomal recessive genetic disorder caused by a defect in the mitochondrial aspartate/glutamate antiporter, citrin.	Aspartic Acid	101-110	solute carrier family 25 member 13	Homo sapiens	133-139
25738356-1	2015	The antitumor enzyme asparaginase, which targets essential amino acid L-asparagine and catalyzes it to L-aspartic acid and ammonia, has been used for years in the treatment of acute lymphoblastic leukemia (ALL), subtypes of myeloid leukemia and T-cell lymphomas, whereas the anti-chronic myeloid leukemia (CML) effect of asparaginase and its underlying mechanism has not been completely elucidated.	Aspartic Acid	103-118	asparaginase	Homo sapiens	21-33
25134804-6	2015	We found an association between the hMSH2 Asp/Asp and Gly/Asp genotypes and TNBC occurence.	Aspartic Acid	42-45	mutS homolog 2	Homo sapiens	36-41
25134804-6	2015	We found an association between the hMSH2 Asp/Asp and Gly/Asp genotypes and TNBC occurence.	Aspartic Acid	46-49	mutS homolog 2	Homo sapiens	36-41
25134804-6	2015	We found an association between the hMSH2 Asp/Asp and Gly/Asp genotypes and TNBC occurence.	Aspartic Acid	46-49	mutS homolog 2	Homo sapiens	36-41
25134804-7	2015	Variant Asp allele of hMSH2 decreased cancer risk [odds ratio (OR) 0.11; 95 % confidence interval (CI) 0.05-0.21].	Aspartic Acid	8-11	mutS homolog 2	Homo sapiens	22-27
25597433-9	2015	Since this carrier is necessary for neuronal functions and is involved in myelinogenesis, our results highlight that targeting of CREB activity and Ca(2+) might be therapeutically exploited to increase aspartate/glutamate carrier gene expression in neurodegenerative diseases.	Aspartic Acid	202-211	cAMP responsive element binding protein 1	Homo sapiens	130-134
25609704-6	2015	Disruption of the MTS through N-terminal insertion of aspartic acid residues results in OMM localization of PINK1 in energized mitochondria.	Aspartic Acid	54-67	PTEN induced kinase 1	Homo sapiens	108-113
25723520-6	2015	The T7 residue of CDC26 is critical for its interaction with APC6, a tetratricopeptide repeat-containing subunit of APC/C, and mutation of this residue to Asp (T7D) reduced the interaction of CDC26 with APC6.	Aspartic Acid	155-158	cell division cycle 16	Homo sapiens	61-65
25723520-6	2015	The T7 residue of CDC26 is critical for its interaction with APC6, a tetratricopeptide repeat-containing subunit of APC/C, and mutation of this residue to Asp (T7D) reduced the interaction of CDC26 with APC6.	Aspartic Acid	155-158	cell division cycle 26	Homo sapiens	192-197
25723520-6	2015	The T7 residue of CDC26 is critical for its interaction with APC6, a tetratricopeptide repeat-containing subunit of APC/C, and mutation of this residue to Asp (T7D) reduced the interaction of CDC26 with APC6.	Aspartic Acid	155-158	cell division cycle 16	Homo sapiens	203-207
25608113-5	2015	Furthermore, the surface modification of the NPs with cyclic arginine-glycine-aspartic acid (cRGD) tripeptide significantly enhances the accumulation of the NPs within integrin alphavbeta3 overexpressed cancer cells.	Aspartic Acid	78-91	integrin subunit alpha V	Homo sapiens	168-188
25597996-11	2015	Further mutation of XRCC4 Asn326 to other amino acids, i.e., alanine, aspartic acid or glutamine did not affect the nuclear localization but still exhibited radiosensitivity.	Aspartic Acid	70-83	X-ray repair cross complementing 4	Homo sapiens	20-25
25451919-4	2015	Intriguingly, CYP3A4 Ser(P)/Thr(P) and ubiquitinated Lys residues reside within the cytosol-accessible surface loop and/or conformationally assembled acidic Asp/Glu clusters, leading us to propose that such post-translational Ser/Thr protein phosphorylation primes CYP3A4 for ubiquitination.	Aspartic Acid	157-160	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-20
25809376-14	2015	CONCLUSION: Our results provide the first description of CD8+ T cell-mediated immune responses to ASP in HIV-1-infected patients, demonstrating that ASP is expressed during infection.	Aspartic Acid	98-101	CD8a molecule	Homo sapiens	57-60
25809376-14	2015	CONCLUSION: Our results provide the first description of CD8+ T cell-mediated immune responses to ASP in HIV-1-infected patients, demonstrating that ASP is expressed during infection.	Aspartic Acid	149-152	CD8a molecule	Homo sapiens	57-60
25528111-5	2015	RESULT: ASP+ is taken up into living serotonergic neurons through the serotonin transporter, but not accumulated into synaptic vesicles; FFN511 diffuses in a SERT-independent way into serotonergic neurons and accumulated into synaptic vesicles.	Aspartic Acid	8-12	solute carrier family 6 member 4	Homo sapiens	70-91
25505265-5	2015	We show that HHAT is comprised of ten transmembrane domains and two reentrant loops with the critical His and Asp residues on opposite sides of the endoplasmic reticulum membrane.	Aspartic Acid	110-113	hedgehog acyltransferase	Homo sapiens	13-17
25451919-4	2015	Intriguingly, CYP3A4 Ser(P)/Thr(P) and ubiquitinated Lys residues reside within the cytosol-accessible surface loop and/or conformationally assembled acidic Asp/Glu clusters, leading us to propose that such post-translational Ser/Thr protein phosphorylation primes CYP3A4 for ubiquitination.	Aspartic Acid	157-160	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	265-271
25451919-6	2015	Our findings reveal that such CYP3A4 Asp/Glu/Ser(P)/Thr(P) surface clusters are indeed important for its intermolecular electrostatic interactions with each of these E2-E3 subcomponents.	Aspartic Acid	37-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
25451919-7	2015	By imparting additional negative charge to these Asp/Glu clusters, such Ser/Thr phosphorylation would generate P450 phosphodegrons for molecular recognition by the E2-E3 complexes, thereby controlling the timing of CYP3A4 ubiquitination and endoplasmic reticulum-associated degradation.	Aspartic Acid	49-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	215-221
25699100-8	2015	Notably, GP IIb/IIIa expression was associated with the vulnerability index and necrotic center/fiber cap ratio (P&lt;0.05), and contrast video intensity from adhered cyclic Arg-Gly-Asp-modified MBs (MB-cRGDs) was correlated with GP IIb/IIIa expression on the plaque surface (P&lt;0.05).	Aspartic Acid	182-185	integrin alpha 2b	Mus musculus	9-15
25663111-3	2015	Mutation of Mip protein on catalytic residues at Aspartate-142 position replaced to Leucine-142 and Tyrosine-185 position replaced to Alanine-185 that strongly reduces the PPIase activity.	Aspartic Acid	49-58	major intrinsic protein of lens fiber	Homo sapiens	12-15
25468444-3	2015	IGFBP-1 and IGFBP-2 have a C-terminal Arg-Gly-Asp (RGD) sequence, and IGFBP-1 has been shown by others to stimulate migration through binding of its RGD sequence to alpha5beta1 integrin.	Aspartic Acid	46-49	insulin like growth factor binding protein 1	Homo sapiens	0-7
24895325-4	2015	Mutation of a critical aspartate to alanine (D1046A) in the PTPRT catalytic domain inactivates phosphatase function but retains substrate binding.	Aspartic Acid	23-32	protein tyrosine phosphatase, receptor type, T	Mus musculus	60-65
25289457-8	2015	As aspartate substitutions have been previously used to mimic cysteine oxidation, we characterized the biochemical properties of Rac1(C18D).	Aspartic Acid	3-12	Rac family small GTPase 1	Homo sapiens	129-133
25463493-3	2015	In this study, surfaces with the mobile Arg-Gly-Asp-Ser (RGDS) peptide have been constructed.	Aspartic Acid	48-51	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	57-61
25468444-3	2015	IGFBP-1 and IGFBP-2 have a C-terminal Arg-Gly-Asp (RGD) sequence, and IGFBP-1 has been shown by others to stimulate migration through binding of its RGD sequence to alpha5beta1 integrin.	Aspartic Acid	46-49	insulin like growth factor binding protein 2	Homo sapiens	12-19
25146482-3	2015	The human class I allotype HLA-B*44:02 with an Asp at position 116 at the floor of the F pocket (which binds the peptide C-terminal residues) depends on tapasin for efficient peptide loading.	Aspartic Acid	47-50	major histocompatibility complex, class I, B	Homo sapiens	27-32
25541374-6	2015	Some of the mutations prevented the stress-induced phosphorylation of eIF2alpha by all mammalian kinases, thus defining amino acid residues in eIF2alpha (Gly 30, Leu 50, and Asp 83) that are required for substrate recognition.	Aspartic Acid	174-177	eukaryotic translation initiation factor 2A	Homo sapiens	70-79
25541374-6	2015	Some of the mutations prevented the stress-induced phosphorylation of eIF2alpha by all mammalian kinases, thus defining amino acid residues in eIF2alpha (Gly 30, Leu 50, and Asp 83) that are required for substrate recognition.	Aspartic Acid	174-177	eukaryotic translation initiation factor 2A	Homo sapiens	143-152
25146482-3	2015	The human class I allotype HLA-B*44:02 with an Asp at position 116 at the floor of the F pocket (which binds the peptide C-terminal residues) depends on tapasin for efficient peptide loading.	Aspartic Acid	47-50	TAP binding protein	Homo sapiens	153-160
25606689-3	2015	Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, in which a reducing equivalent is transported via malate, which when oxidized to oxaloacetate, transfers an electron pair to reduce NAD to NADH.	Aspartic Acid	81-90	malic enzyme 1	Homo sapiens	18-38
25373728-6	2015	Using the described method for detecting histidine and aspartic acid phosphorylations and our prostate cancer progression cell system, the potential function of NM23-H1 in suppressing metastasis with a two-component regulation system is discussed.	Aspartic Acid	55-68	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	161-168
25608886-4	2015	In this study, we dissected the molecular mechanisms by which CCL2 neutralization inhibits HIV-1 replication in monocyte-derived macrophages (MDM), and the potential involvement of the innate restriction factors protein sterile alpha motif (SAM) histidine/aspartic acid (HD) domain containing 1 (SAMHD1) and apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) family members.	Aspartic Acid	256-269	C-C motif chemokine ligand 2	Homo sapiens	62-66
25548962-7	2015	The calculations also show that the protonation state of the aspartate residue in the DFG motif strongly affects the in/out conformational transition in c-Abl, although it has a much smaller impact in the case of c-Src due to local structural differences.	Aspartic Acid	61-70	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	153-158
25548962-7	2015	The calculations also show that the protonation state of the aspartate residue in the DFG motif strongly affects the in/out conformational transition in c-Abl, although it has a much smaller impact in the case of c-Src due to local structural differences.	Aspartic Acid	61-70	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	213-218
25606689-3	2015	Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, in which a reducing equivalent is transported via malate, which when oxidized to oxaloacetate, transfers an electron pair to reduce NAD to NADH.	Aspartic Acid	81-90	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	40-43
25425647-0	2015	Evidence for an elevated aspartate pK(a) in the active site of human aromatase.	Aspartic Acid	25-34	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	69-78
25630260-10	2015	This was partially blocked by the CAT antagonist aspartate (1 mm) and also by PAG.	Aspartic Acid	49-58	catalase	Rattus norvegicus	34-37
25479244-7	2015	The protein sample is treated with trypsin, trypsin plus Asp-N, trypsin plus PIMT, trypsin plus paenidase, and the resulting peptides are applied to LC-MS. Because Asp-N hydrolyzes peptide bonds on the N-terminus of only Lalpha-Asp residues, it differentiates peptides containing Lalpha-Asp from those containing the other three isomers.	Aspartic Acid	164-167	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	77-81
25479244-7	2015	The protein sample is treated with trypsin, trypsin plus Asp-N, trypsin plus PIMT, trypsin plus paenidase, and the resulting peptides are applied to LC-MS. Because Asp-N hydrolyzes peptide bonds on the N-terminus of only Lalpha-Asp residues, it differentiates peptides containing Lalpha-Asp from those containing the other three isomers.	Aspartic Acid	164-167	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	77-81
25479244-7	2015	The protein sample is treated with trypsin, trypsin plus Asp-N, trypsin plus PIMT, trypsin plus paenidase, and the resulting peptides are applied to LC-MS. Because Asp-N hydrolyzes peptide bonds on the N-terminus of only Lalpha-Asp residues, it differentiates peptides containing Lalpha-Asp from those containing the other three isomers.	Aspartic Acid	164-167	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	77-81
25479244-8	2015	Similarly, PIMT recognizes only peptides containing Lbeta-Asp residues, and paenidase internally cleaves the C-terminus of Dalpha-Asp residues.	Aspartic Acid	58-61	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	11-15
25572553-2	2015	Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad.	Aspartic Acid	136-139	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	37-41
25572553-2	2015	Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad.	Aspartic Acid	136-139	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	10-14
28509452-4	2015	We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.	Aspartic Acid	43-46	F11 receptor	Homo sapiens	87-91
28509452-4	2015	We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.	Aspartic Acid	43-46	F11 receptor	Homo sapiens	134-139
28509452-4	2015	We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.	Aspartic Acid	60-63	F11 receptor	Homo sapiens	87-91
28509452-4	2015	We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.	Aspartic Acid	60-63	F11 receptor	Homo sapiens	134-139
25572553-2	2015	Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad.	Aspartic Acid	136-139	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	43-48
25987027-8	2015	ASP induced redistribution of STAT5 protein from the cytoplasm to the nucleus.	Aspartic Acid	0-3	signal transducer and activator of transcription 5A	Homo sapiens	30-35
25287256-0	2015	Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase?	Aspartic Acid	5-14	glutamic-oxaloacetic transaminase 1-like 1	Mus musculus	27-69
25287256-0	2015	Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase?	Aspartic Acid	5-14	glutamic-oxaloacetic transaminase 1-like 1	Mus musculus	71-77
25287256-5	2015	Recently, mouse glutamic-oxaloacetic transaminase 1-like 1 (Got1l1) has been reported to synthesize substantially D-aspartate from L-aspartate and to be involved in adult neurogenesis.	Aspartic Acid	131-142	glutamic-oxaloacetic transaminase 1-like 1	Mus musculus	16-58
25287256-5	2015	Recently, mouse glutamic-oxaloacetic transaminase 1-like 1 (Got1l1) has been reported to synthesize substantially D-aspartate from L-aspartate and to be involved in adult neurogenesis.	Aspartic Acid	131-142	glutamic-oxaloacetic transaminase 1-like 1	Mus musculus	60-66
25987027-9	2015	Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/ STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway.	Aspartic Acid	50-53	erythropoietin	Homo sapiens	98-112
25987027-9	2015	Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/ STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway.	Aspartic Acid	50-53	erythropoietin	Homo sapiens	114-117
25987027-9	2015	Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/ STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway.	Aspartic Acid	50-53	erythropoietin	Homo sapiens	133-136
25987027-9	2015	Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/ STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway.	Aspartic Acid	50-53	Janus kinase 2	Homo sapiens	145-149
25987027-9	2015	Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/ STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway.	Aspartic Acid	50-53	signal transducer and activator of transcription 5A	Homo sapiens	151-156
25987027-9	2015	Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/ STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway.	Aspartic Acid	50-53	erythropoietin	Homo sapiens	133-136
25987027-9	2015	Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/ STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway.	Aspartic Acid	50-53	Janus kinase 2	Homo sapiens	216-220
25987027-9	2015	Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/ STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway.	Aspartic Acid	50-53	signal transducer and activator of transcription 5A	Homo sapiens	221-226
25835182-4	2015	It has been found that the genotype 751Gln/Gln and allele Gln of ERCC2 gene and allele Asp of 312Asn/Asp polymorphism of ERCC2 gene may be associated with an increased risk of colorectal cancer.	Aspartic Acid	87-90	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	121-126
25338779-0	2015	Effect of the replacement of aspartic acid/glutamic acid residues with asparagine/glutamine residues in RNase He1 from Hericium erinaceus on inhibition of human leukemia cell line proliferation.	Aspartic Acid	29-42	NPC intracellular cholesterol transporter 2	Homo sapiens	110-113
25415237-6	2015	Our results show that bifendate, AAP, ASP, and AMP significantly decreased the activities of MDA, AST, and ALT, and enhanced the activity of SOD in CCl4-treated mice.	Aspartic Acid	38-41	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	98-101
25415237-6	2015	Our results show that bifendate, AAP, ASP, and AMP significantly decreased the activities of MDA, AST, and ALT, and enhanced the activity of SOD in CCl4-treated mice.	Aspartic Acid	38-41	glutamic pyruvic transaminase, soluble	Mus musculus	107-110
25415237-6	2015	Our results show that bifendate, AAP, ASP, and AMP significantly decreased the activities of MDA, AST, and ALT, and enhanced the activity of SOD in CCl4-treated mice.	Aspartic Acid	38-41	chemokine (C-C motif) ligand 4	Mus musculus	148-152
25415237-7	2015	Bifendate, AAP, ASP, and AMP consistently ameliorated the liver injuries induced with CCl4.	Aspartic Acid	16-19	chemokine (C-C motif) ligand 4	Mus musculus	86-90
25835182-4	2015	It has been found that the genotype 751Gln/Gln and allele Gln of ERCC2 gene and allele Asp of 312Asn/Asp polymorphism of ERCC2 gene may be associated with an increased risk of colorectal cancer.	Aspartic Acid	101-104	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	121-126
25218309-1	2015	The synthetic 15-mer arginine-glycine-aspartic acid (RGD) domain of osteopontin (OPN) is protective in vitro and in vivo against dopaminergic cell death and this protective effect may be mediated through interaction with integrin receptors to regulate neurotrophic factor levels.	Aspartic Acid	38-51	secreted phosphoprotein 1	Rattus norvegicus	68-79
26317891-10	2015	Aspartate provides less protection from doxorubicin in cells mutant in either mitochondrial citrate synthase (CIT1) or NADH oxidase (NDI1), suggesting aspartate reduces doxorubicin toxicity by facilitating mitochondrial function.	Aspartic Acid	0-9	citrate (Si)-synthase CIT1	Saccharomyces cerevisiae S288C	110-114
26317891-10	2015	Aspartate provides less protection from doxorubicin in cells mutant in either mitochondrial citrate synthase (CIT1) or NADH oxidase (NDI1), suggesting aspartate reduces doxorubicin toxicity by facilitating mitochondrial function.	Aspartic Acid	0-9	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	133-137
26317891-10	2015	Aspartate provides less protection from doxorubicin in cells mutant in either mitochondrial citrate synthase (CIT1) or NADH oxidase (NDI1), suggesting aspartate reduces doxorubicin toxicity by facilitating mitochondrial function.	Aspartic Acid	151-160	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	133-137
25218309-1	2015	The synthetic 15-mer arginine-glycine-aspartic acid (RGD) domain of osteopontin (OPN) is protective in vitro and in vivo against dopaminergic cell death and this protective effect may be mediated through interaction with integrin receptors to regulate neurotrophic factor levels.	Aspartic Acid	38-51	secreted phosphoprotein 1	Rattus norvegicus	81-84
25218309-1	2015	The synthetic 15-mer arginine-glycine-aspartic acid (RGD) domain of osteopontin (OPN) is protective in vitro and in vivo against dopaminergic cell death and this protective effect may be mediated through interaction with integrin receptors to regulate neurotrophic factor levels.	Aspartic Acid	38-51	neurotrophin 3	Rattus norvegicus	252-271
25381060-6	2015	Furthermore, we showed for the first time that CCP1 processes both glutamates as well as C-terminal aspartates.	Aspartic Acid	100-110	ATP/GTP binding carboxypeptidase 1	Homo sapiens	47-51
25359495-6	2015	Using site-directed mutagenesis, we showed that Asp 92, Glu 172, and Asp 282 of rat ApelinR are key residues in apelin binding by interacting with Lys 8, Arg 2, and Arg 4 of pE13F, respectively.	Aspartic Acid	48-51	apelin	Rattus norvegicus	112-118
25359495-6	2015	Using site-directed mutagenesis, we showed that Asp 92, Glu 172, and Asp 282 of rat ApelinR are key residues in apelin binding by interacting with Lys 8, Arg 2, and Arg 4 of pE13F, respectively.	Aspartic Acid	48-51	arginase 2	Rattus norvegicus	154-159
26316659-9	2015	Students across the academic spectrum appeared to have learned the MIM ASP Course content - high school GPA was not a predictor of knowledge acquisition.	Aspartic Acid	71-74	MTSS I-BAR domain containing 1	Homo sapiens	67-70
26316659-13	2015	The qualitative evaluation found that the students and their parents were pleased with the MIM ASP Course"s composition, presentation, and effectiveness.	Aspartic Acid	95-98	MTSS I-BAR domain containing 1	Homo sapiens	91-94
26316659-17	2015	The MIM ASP Course appears to have achieved its principal educational objectives of providing academic enrichment in human biology and improving attitudes towards a health career for a self-selected population of disadvantaged, underrepresented minority high school students in an urban setting.	Aspartic Acid	8-11	MTSS I-BAR domain containing 1	Homo sapiens	4-7
25968339-6	2015	We found that apoptotic caspase activity cleaves inhibitor of apoptosis 2 at an N-terminal aspartate to generate a truncated protein that retains the ability to interact with immune deficiency pathway members.	Aspartic Acid	91-100	Death-associated inhibitor of apoptosis 2	Drosophila melanogaster	49-73
25284025-1	2015	UNLABELLED: HOM6 is a major gene in the aspartate pathway which leads to biosynthesis of threonine and methionine.	Aspartic Acid	40-49	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	12-16
25284025-6	2015	We propose that Mn(2+) and H2 O2 promote the growth of hom6  by reducing the accumulation of the toxic intermediate metabolite-aspartate beta-semialdehyde, via directing the aspartate pathway to the central sugar metabolism-tricarboxylic acid cycle.	Aspartic Acid	127-136	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	55-59
25284025-6	2015	We propose that Mn(2+) and H2 O2 promote the growth of hom6  by reducing the accumulation of the toxic intermediate metabolite-aspartate beta-semialdehyde, via directing the aspartate pathway to the central sugar metabolism-tricarboxylic acid cycle.	Aspartic Acid	174-183	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	55-59
25284025-7	2015	SIGNIFICANCE AND IMPACT OF THE STUDY: This study focuses on the yeast strain which lacks homoserine dehydrogenase encoded by HOM6 gene in aspartate metabolism.	Aspartic Acid	138-147	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	125-129
25359495-6	2015	Using site-directed mutagenesis, we showed that Asp 92, Glu 172, and Asp 282 of rat ApelinR are key residues in apelin binding by interacting with Lys 8, Arg 2, and Arg 4 of pE13F, respectively.	Aspartic Acid	69-72	apelin	Rattus norvegicus	112-118
25359495-6	2015	Using site-directed mutagenesis, we showed that Asp 92, Glu 172, and Asp 282 of rat ApelinR are key residues in apelin binding by interacting with Lys 8, Arg 2, and Arg 4 of pE13F, respectively.	Aspartic Acid	69-72	arginase 2	Rattus norvegicus	154-159
26349490-5	2015	It is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic acid (RGD) tripeptide sequence and therefore RGD peptides can preferentially bind to integrin alphavbeta3.	Aspartic Acid	89-102	integrin subunit alpha V	Homo sapiens	183-203
26978505-4	2015	RESULTS AND CONCLUSION: In the cells with PARK2 mutations, the level of DAT expression was significantly higher than in normal neurons, but the intensity of ASP+ capture by mutant dopaminergic neurons was 25% down from normal neurons.	Aspartic Acid	157-161	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	42-47
25394783-1	2015	Human aspartyl-(asparaginyl)-beta-hydroxylase (HAAH) is a type 2 transmembrane protein and an alpha-ketoglutarate-dependent dioxygenase that can stereospecifically catalyze the post-translational hydroxylation reaction of beta-carbon atoms of aspartic acid and asparagine residues present in epidermal growth factor-like domains of certain specific proteins.	Aspartic Acid	243-256	aspartate beta-hydroxylase	Homo sapiens	6-45
25394783-1	2015	Human aspartyl-(asparaginyl)-beta-hydroxylase (HAAH) is a type 2 transmembrane protein and an alpha-ketoglutarate-dependent dioxygenase that can stereospecifically catalyze the post-translational hydroxylation reaction of beta-carbon atoms of aspartic acid and asparagine residues present in epidermal growth factor-like domains of certain specific proteins.	Aspartic Acid	243-256	aspartate beta-hydroxylase	Homo sapiens	47-51
25845638-12	2015	The immunoblotting confirmed that ASP attenuated inhibition of phosphorylation of Akt and hTERT induced by ox-LDL and down-regulated increased the expression of gp91-phox.	Aspartic Acid	34-37	telomerase reverse transcriptase	Homo sapiens	90-95
25845638-16	2015	CONCLUSION: Treatment of EPCs with ASP remarkably attenuates the harmful effects of ox-LDL via augmentation of Akt/hTERT phosphorylation and inhibition of oxidative stress.	Aspartic Acid	35-38	telomerase reverse transcriptase	Homo sapiens	115-120
26095376-1	2015	An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective.	Aspartic Acid	52-55	proopiomelanocortin	Homo sapiens	3-12
26095376-1	2015	An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective.	Aspartic Acid	52-55	metallothionein 2A	Homo sapiens	37-41
25677767-5	2015	In search of higher agonist potency, two lysine and two aspartate residues were strategically incorporated into the receptor-binding C-terminus of the nociceptin sequence and two Lys(i) Asp(i+4) side chain-side chain condensations were used to generate lactam cross-links that constrained nociceptin into a highly stable alpha-helix in water.	Aspartic Acid	56-65	prepronociceptin	Rattus norvegicus	151-161
25993799-13	2015	CONCLUSION: ASP can induce human leukemia stem cell senescence in vitro, the mechanism involved may be related to ASP regulation P16-Rb signaling pathways.	Aspartic Acid	12-15	cyclin dependent kinase inhibitor 2A	Homo sapiens	129-132
25993799-13	2015	CONCLUSION: ASP can induce human leukemia stem cell senescence in vitro, the mechanism involved may be related to ASP regulation P16-Rb signaling pathways.	Aspartic Acid	114-117	cyclin dependent kinase inhibitor 2A	Homo sapiens	129-132
26112741-3	2015	The present study explored whether SPAK and/or OSR1 influence the excitatory amino acid transporter EAAT3, which accomplishes glutamate and aspartate transport in kidney, intestine and brain.	Aspartic Acid	140-149	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	100-105
25561575-4	2015	A comparison of the loop L1 structures in a DNA-free RecA crystal that we originally determined and in the reported DNA-bound active RecA crystals suggested that the aspartate at position 161 in loop L1 in DNA-free RecA prevented double-stranded, but not single-stranded, DNA-binding to the primary site.	Aspartic Acid	166-175	RAD51 recombinase	Homo sapiens	53-57
25561575-4	2015	A comparison of the loop L1 structures in a DNA-free RecA crystal that we originally determined and in the reported DNA-bound active RecA crystals suggested that the aspartate at position 161 in loop L1 in DNA-free RecA prevented double-stranded, but not single-stranded, DNA-binding to the primary site.	Aspartic Acid	166-175	RAD51 recombinase	Homo sapiens	133-137
25561575-4	2015	A comparison of the loop L1 structures in a DNA-free RecA crystal that we originally determined and in the reported DNA-bound active RecA crystals suggested that the aspartate at position 161 in loop L1 in DNA-free RecA prevented double-stranded, but not single-stranded, DNA-binding to the primary site.	Aspartic Acid	166-175	RAD51 recombinase	Homo sapiens	133-137
25561575-8	2015	Thus, Asp-161 in the flexible loop L1 of wild-type RecA determines the preference for single-stranded DNA-binding to the primary site and regulates the DNA-binding order in RecA-catalyzed recombinase reactions.	Aspartic Acid	6-9	RAD51 recombinase	Homo sapiens	51-55
25561575-8	2015	Thus, Asp-161 in the flexible loop L1 of wild-type RecA determines the preference for single-stranded DNA-binding to the primary site and regulates the DNA-binding order in RecA-catalyzed recombinase reactions.	Aspartic Acid	6-9	RAD51 recombinase	Homo sapiens	173-177
25230085-1	2014	Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad.	Aspartic Acid	169-172	phospholipase A2 group IB	Homo sapiens	11-27
25352594-3	2014	Vpu-induced IRF3 cleavage is mediated by caspases and occurs mainly at Asp-121.	Aspartic Acid	71-74	Vpu	Human immunodeficiency virus 1	0-3
25352594-3	2014	Vpu-induced IRF3 cleavage is mediated by caspases and occurs mainly at Asp-121.	Aspartic Acid	71-74	interferon regulatory factor 3	Homo sapiens	12-16
25342751-4	2014	The sole negatively charged residue in the first half of human tropoelastin is aspartate 72.	Aspartic Acid	79-88	elastin	Homo sapiens	63-75
25342751-10	2014	Our results strongly point to the role of the Asp-72 site in stabilizing the N-terminal segment of human tropoelastin and the importance of this region in facilitating elastic fiber assembly.	Aspartic Acid	46-49	elastin	Homo sapiens	105-117
25490769-8	2014	Also, we show preferential cleavage by granzyme B at one of two available aspartates (either D161 or D122) in M7-NPM and Y67E-NPM, whereas wild-type NPM1 was cleaved at both sites.	Aspartic Acid	74-84	granzyme B	Homo sapiens	39-49
25553350-2	2014	CASP8 D302H (rs1045485) (D, Aspartate; H, Histidine) and CASP8 -652 6N del (rs3834129) polymorphisms have been reported to be associated with Cancer susceptibility.	Aspartic Acid	28-37	caspase 8	Homo sapiens	0-5
25378404-6	2014	Here, by using patch clamp and molecular biological techniques, we show that there are at least two functionally different divalent cation-binding sites, and the negatively charged amino acids near and in the TRP domain in the C-terminal tail of TRPM4 (Asp-1049 and Glu-1062 of rat TRPM4) are required for maintaining the normal Ca(2+) sensitivity of one of the binding sites.	Aspartic Acid	253-256	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	246-251
25378404-6	2014	Here, by using patch clamp and molecular biological techniques, we show that there are at least two functionally different divalent cation-binding sites, and the negatively charged amino acids near and in the TRP domain in the C-terminal tail of TRPM4 (Asp-1049 and Glu-1062 of rat TRPM4) are required for maintaining the normal Ca(2+) sensitivity of one of the binding sites.	Aspartic Acid	253-256	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	282-287
25442979-1	2014	BACKGROUND: Elevated serum aspartate and alanine aminotransferase (AST and ALT) are often observed in patients with acute ST-segment elevation myocardial infarction (STEMI) and the condition is ascribed to liver hypoperfusion.	Aspartic Acid	27-36	solute carrier family 17 member 5	Homo sapiens	67-70
25339174-5	2014	In the human dopamine transporter (DAT), the corresponding residues are Arg-85 and Asp-476.	Aspartic Acid	83-86	solute carrier family 6 member 3	Homo sapiens	13-33
25339174-5	2014	In the human dopamine transporter (DAT), the corresponding residues are Arg-85 and Asp-476.	Aspartic Acid	83-86	solute carrier family 6 member 3	Homo sapiens	35-38
25135661-10	2014	Docking studies and mutational analyses identified residues involved in NAT12 nucleobase binding including Ser-247, Phe-248, Asp-461, Thr-507 and Thr-508.	Aspartic Acid	125-128	nucleobase-ascorbate transporter 12	Arabidopsis thaliana	72-77
25230085-1	2014	Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad.	Aspartic Acid	169-172	phospholipase A2 group IB	Homo sapiens	29-33
25230085-1	2014	Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad.	Aspartic Acid	169-172	phospholipase A2 group IB	Homo sapiens	57-61
25230085-1	2014	Within the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad.	Aspartic Acid	169-172	phospholipase A2 group IIA	Homo sapiens	63-68
25331670-4	2014	The molecular docking study of T1R1 and T1R3 in complex with four peptides, including Lys-Gly-Asp-Glu-Ser-Leu-Leu-Ala, Ser-Glu-Glu, G1u-Ser, and Asp-Glu-Ser, displayed that the amino acid residue of SER146 and Glu277 in T1R3 may play great roles in the synergism of umami taste.	Aspartic Acid	94-97	taste 1 receptor member 1	Homo sapiens	31-35
25444154-9	2014	Furthermore, it showed a higher OAS rate in the case of low versus high ASP (1-year-OAS, 91% vs. 67%: p=0.02).	Aspartic Acid	72-75	SPARC related modular calcium binding 1	Homo sapiens	32-35
25444154-9	2014	Furthermore, it showed a higher OAS rate in the case of low versus high ASP (1-year-OAS, 91% vs. 67%: p=0.02).	Aspartic Acid	72-75	SPARC related modular calcium binding 1	Homo sapiens	84-87
25331670-4	2014	The molecular docking study of T1R1 and T1R3 in complex with four peptides, including Lys-Gly-Asp-Glu-Ser-Leu-Leu-Ala, Ser-Glu-Glu, G1u-Ser, and Asp-Glu-Ser, displayed that the amino acid residue of SER146 and Glu277 in T1R3 may play great roles in the synergism of umami taste.	Aspartic Acid	94-97	taste 1 receptor member 3	Homo sapiens	40-44
25331670-4	2014	The molecular docking study of T1R1 and T1R3 in complex with four peptides, including Lys-Gly-Asp-Glu-Ser-Leu-Leu-Ala, Ser-Glu-Glu, G1u-Ser, and Asp-Glu-Ser, displayed that the amino acid residue of SER146 and Glu277 in T1R3 may play great roles in the synergism of umami taste.	Aspartic Acid	145-148	taste 1 receptor member 1	Homo sapiens	31-35
25001194-1	2014	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and Ala-Thr-Trp-Leu-Pro-Pro-Arg (ATWLPPR) peptide analogs have received interests for their capability to serve as radiopharmaceuticals for imaging integrin alphavbeta3 and Neuropilin-1 (NRP-1) positive tumors, respectively.	Aspartic Acid	30-33	integrin subunit alpha V	Homo sapiens	188-208
25331670-4	2014	The molecular docking study of T1R1 and T1R3 in complex with four peptides, including Lys-Gly-Asp-Glu-Ser-Leu-Leu-Ala, Ser-Glu-Glu, G1u-Ser, and Asp-Glu-Ser, displayed that the amino acid residue of SER146 and Glu277 in T1R3 may play great roles in the synergism of umami taste.	Aspartic Acid	145-148	taste 1 receptor member 3	Homo sapiens	40-44
25007879-8	2014	Furthermore, site-directed mutagenesis in a phage display system revealed that Asp(6.59) might be a common NPY-binding site, while Asp(2.68) of the Y8b receptor and Glu(5.24) of the Y2 receptor could be likely involved in subtype-specific binding.	Aspartic Acid	79-82	neuropeptide Y	Homo sapiens	107-110
25212678-7	2014	In this study we show a new structural variant of alpha-chain, Hb Cibeles [alpha 25(B6) Gly   Asp], in heterozygous state, which was undetectable by electrophoretic or chromatographic methods.	Aspartic Acid	94-97	Fc gamma receptor and transporter	Homo sapiens	50-61
25001194-1	2014	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and Ala-Thr-Trp-Leu-Pro-Pro-Arg (ATWLPPR) peptide analogs have received interests for their capability to serve as radiopharmaceuticals for imaging integrin alphavbeta3 and Neuropilin-1 (NRP-1) positive tumors, respectively.	Aspartic Acid	30-33	neuropilin 1	Homo sapiens	213-225
24994558-6	2014	The 18 bp deletion of six amino acids, Ser-Asp-Ser-Glu-Glu-Glu (798*803), which was located in the CKII phosphorylation site of treacle, seemed relatively benign for TCS.	Aspartic Acid	43-46	casein kinase 2 alpha 1	Homo sapiens	99-103
24994558-6	2014	The 18 bp deletion of six amino acids, Ser-Asp-Ser-Glu-Glu-Glu (798*803), which was located in the CKII phosphorylation site of treacle, seemed relatively benign for TCS.	Aspartic Acid	43-46	treacle ribosome biogenesis factor 1	Homo sapiens	166-169
25001194-1	2014	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and Ala-Thr-Trp-Leu-Pro-Pro-Arg (ATWLPPR) peptide analogs have received interests for their capability to serve as radiopharmaceuticals for imaging integrin alphavbeta3 and Neuropilin-1 (NRP-1) positive tumors, respectively.	Aspartic Acid	30-33	neuropilin 1	Homo sapiens	227-232
25489668-4	2014	Here, we apply GzmB"s preference for cleavage after aspartic acid residues in a colorimetric assay using the peptide thioester Boc-Ala-Ala-Asp-S-Bzl.	Aspartic Acid	52-65	granzyme B	Homo sapiens	15-19
25310453-6	2014	Among the binding residues, the C-terminal residues like aspartate (D) 116, glutamine (Q) 117, tryptophan (W) 118 and leucine (L) 119 are destabilized and disordered and can dock beta4GalT onto Ca(2+)-aLA.	Aspartic Acid	57-66	lactalbumin alpha	Homo sapiens	201-204
25316116-6	2014	Conversely, only the Dag1 and Dag2 peptides exhibit some chain reversal; replacing the second aspartic-acid residue with a valine and the first one with a basic residue results in a nearly extended conformation.	Aspartic Acid	94-107	dystroglycan 1	Homo sapiens	21-25
25316116-6	2014	Conversely, only the Dag1 and Dag2 peptides exhibit some chain reversal; replacing the second aspartic-acid residue with a valine and the first one with a basic residue results in a nearly extended conformation.	Aspartic Acid	94-107	sarcoglycan alpha	Homo sapiens	30-34
25504019-6	2014	Direct sequencing of all 20 exons of the TCIRG1 gene revealed a single nucleotide change in exon 11 (c1305 G &gt; T), which causes the substitution of Asp (GAT) for Glu (GAG) at position 435, and a two-nucleotide deletion in exon 16 (c1952-1953 del CA), causing a frame-shift mutation.	Aspartic Acid	151-154	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	41-47
25504019-6	2014	Direct sequencing of all 20 exons of the TCIRG1 gene revealed a single nucleotide change in exon 11 (c1305 G &gt; T), which causes the substitution of Asp (GAT) for Glu (GAG) at position 435, and a two-nucleotide deletion in exon 16 (c1952-1953 del CA), causing a frame-shift mutation.	Aspartic Acid	151-154	glycine-N-acyltransferase	Homo sapiens	156-159
25342745-0	2014	The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.	Aspartic Acid	50-53	MARVEL domain containing 2	Homo sapiens	24-28
25342745-0	2014	The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.	Aspartic Acid	50-53	CCT	Homo sapiens	29-32
25342745-0	2014	The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.	Aspartic Acid	50-53	DDB1 and CUL4 associated factor 7	Homo sapiens	79-84
25342745-0	2014	The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.	Aspartic Acid	50-53	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	126-132
25431414-7	2014	In the course of chronic ASP administration, the following was observed: the concentration of reduced glutathione (GSH) and the activity of catalase (CAT) increased.	Aspartic Acid	25-28	catalase	Rattus norvegicus	140-148
25431414-7	2014	In the course of chronic ASP administration, the following was observed: the concentration of reduced glutathione (GSH) and the activity of catalase (CAT) increased.	Aspartic Acid	25-28	catalase	Rattus norvegicus	150-153
25310523-7	2014	Further study revealed that a single nucleotide polymorphism (SNP) of S100A4 (rs1803245; c.29A&gt;T), which substitutes an Asp residue with Val (D10V), is localized within the conserved binding surface for Annexin II.	Aspartic Acid	123-126	S100 calcium binding protein A4	Homo sapiens	70-76
25310523-7	2014	Further study revealed that a single nucleotide polymorphism (SNP) of S100A4 (rs1803245; c.29A&gt;T), which substitutes an Asp residue with Val (D10V), is localized within the conserved binding surface for Annexin II.	Aspartic Acid	123-126	annexin A2	Homo sapiens	206-216
25489668-4	2014	Here, we apply GzmB"s preference for cleavage after aspartic acid residues in a colorimetric assay using the peptide thioester Boc-Ala-Ala-Asp-S-Bzl.	Aspartic Acid	52-65	BOC cell adhesion associated, oncogene regulated	Homo sapiens	127-130
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Aspartic Acid	20-23	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25368151-4	2014	Bioinformatic analysis of the DHHC (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the catalytic domain) family of enzymes that catalyze protein palmitoylation revealed that one member, DHHC6, contains a predicted Src-homology 3 (SH3) domain and DHHC6 is localized to the ER membrane.	Aspartic Acid	70-83	zinc finger DHHC-type palmitoyltransferase 6	Homo sapiens	226-231
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Aspartic Acid	100-103	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Aspartic Acid	100-103	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Aspartic Acid	100-103	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25427151-6	2014	The results of this study have pointed to a central role of the conserved His-Arg-Asp (HRD) motif in the catalytic loop and the Asp-Phe-Gly (DFG) motif as key mediators of structural stability and allosteric communications in the ErbB kinases.	Aspartic Acid	82-85	epidermal growth factor receptor	Homo sapiens	230-234
25294873-4	2014	After confirming its type III activity generating only omega-N(G)-monomethylarginine and its distinct substrate specificity for RXR motifs surrounded by basic residues, we performed site-directed mutagenesis studies on this enzyme, revealing that two acidic residues within the double E loop, Asp-147 and Glu-149, modulate the substrate preference.	Aspartic Acid	293-296	retinoid X receptor alpha	Homo sapiens	128-131
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Aspartic Acid	100-103	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25469049-9	2014	In terms of the XPD Asp312Asn polymorphism, significantly increased EC risks were identified in the Asp/Asn vs Asp/Asp comparison (OR = 1.17, 95%CI: 1.02-1.33, P = 0.03) and in the dominant-model comparison (Asn/Asn+Asp/Asn vs Asp/Asp: OR = 1.18, 95%CI: 1.04-1.34, P = 0.01).	Aspartic Acid	100-103	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25347607-7	2014	On the basis of our calculations and analysis of other GPCR crystal structures, we suggest that the protonation state of Asp(2.50) may act as a functionally important microswitch in the activation of the beta2AR and other class A receptors.	Aspartic Acid	121-124	adrenoceptor beta 2	Homo sapiens	204-211
25419572-2	2014	OPN primarily exerts its functions through interaction with integrins via the Arg-Gly-Asp and Ser-Val-Val-Tyr-Gly-Leu-Arg sequences located in the N-terminal part of the protein.	Aspartic Acid	86-89	secreted phosphoprotein 1	Homo sapiens	0-3
25418295-4	2014	Like other calcium channels, RyR has four aspartate residues in its GGGIGDE selectivity filter.	Aspartic Acid	42-51	ryanodine receptor 1	Homo sapiens	29-32
25234727-5	2014	This Asp-rich domain was highly conserved in all plant DSR6 homologs identified and shared a sequence identity with the N-terminal regions of yeast p23(fyp) and human hTCTP, which contain Rab protein binding sites.	Aspartic Acid	5-8	tumor protein, translationally-controlled 1	Homo sapiens	167-172
24766780-3	2014	The combined (1)H-NMR spectroscopic and molecular dynamics methods were used to investigate the conformational behavior of an Arg-Gly-Asp (RGD)-containing peptide, GRGDSPC, the cell-binding heptapeptide of extracellular matrix protein, fibronectin.	Aspartic Acid	134-137	fibronectin 1	Homo sapiens	236-247
25550928-7	2014	Overall, a significant association was found between the XPG Asp1104His polymorphism and the risk of gastrointestinal cancers (dominant model: OR = 1.15, 95% CI: 1.05-1.26; His/His vs. Asp/Asp: OR = 1.15, 95% CI: 1.01-1.32).	Aspartic Acid	61-64	ERCC excision repair 5, endonuclease	Homo sapiens	57-60
25550928-7	2014	Overall, a significant association was found between the XPG Asp1104His polymorphism and the risk of gastrointestinal cancers (dominant model: OR = 1.15, 95% CI: 1.05-1.26; His/His vs. Asp/Asp: OR = 1.15, 95% CI: 1.01-1.32).	Aspartic Acid	185-188	ERCC excision repair 5, endonuclease	Homo sapiens	57-60
25501157-5	2014	Mutation analysis revealed a novel mutation at exon 10 of the FGFR1 gene, 1422 C&gt;G, and a C G transition in codon 476, which resulted in the replacement of aspartic acid with glutamic acid.	Aspartic Acid	159-172	fibroblast growth factor receptor 1	Homo sapiens	62-67
25278441-6	2014	Next, modified Abeta molecules were coupled to the carboxyl groups of Asp and Asp12 using bromoethylamine as a spacer.	Aspartic Acid	70-73	amyloid beta (A4) precursor protein	Mus musculus	15-20
25253687-9	2014	Unexpectedly, IFP1.4 with Asp-207 reinstalled (IFPrev) has a higher fluorescence quantum yield (~9%) than most NIR phytofluors published to date.	Aspartic Acid	26-29	tripartite motif containing 34	Homo sapiens	14-18
25370744-4	2014	Melanoma-predisposing CDKN2A germline mutations, which affect conserved glycine and aspartate residues within the GHDDGQ motif, impair the ability of ARF to control superoxide production and suppress growth of melanoma cells in vivo.	Aspartic Acid	84-93	cyclin dependent kinase inhibitor 2A	Homo sapiens	22-28
25251774-0	2014	The aspartic acid of Fyn at 390 is critical for neuronal migration during corticogenesis.	Aspartic Acid	4-17	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
25251774-7	2014	Our work provides in vivo and in vitro evidence that the aspartic acid of Fyn at 390 is indispensable for the radial migration, and it is required for precise cooperation with focal adhesion kinase.	Aspartic Acid	57-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
25218037-0	2014	A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.	Aspartic Acid	62-65	parathyroid hormone	Homo sapiens	32-51
25218037-0	2014	A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.	Aspartic Acid	62-65	parathyroid hormone	Homo sapiens	53-56
25218037-0	2014	A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.	Aspartic Acid	62-65	parathyroid hormone 1 receptor	Homo sapiens	77-90
25218037-2	2014	PTH"s interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of interactions with the receptor: a charge-charge interaction with Asp-137; hydrogen bonds with the backbone of Asp-29 and Met-32; and hydrophobic interactions with Met-32 and Gln-37.	Aspartic Acid	187-190	parathyroid hormone	Homo sapiens	0-3
25218037-2	2014	PTH"s interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of interactions with the receptor: a charge-charge interaction with Asp-137; hydrogen bonds with the backbone of Asp-29 and Met-32; and hydrophobic interactions with Met-32 and Gln-37.	Aspartic Acid	187-190	parathyroid hormone	Homo sapiens	48-52
25218037-2	2014	PTH"s interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of interactions with the receptor: a charge-charge interaction with Asp-137; hydrogen bonds with the backbone of Asp-29 and Met-32; and hydrophobic interactions with Met-32 and Gln-37.	Aspartic Acid	232-235	parathyroid hormone	Homo sapiens	0-3
25218037-2	2014	PTH"s interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of interactions with the receptor: a charge-charge interaction with Asp-137; hydrogen bonds with the backbone of Asp-29 and Met-32; and hydrophobic interactions with Met-32 and Gln-37.	Aspartic Acid	232-235	parathyroid hormone	Homo sapiens	48-52
25218037-7	2014	These data demonstrate that a negative charge at residue-137 is important for interacting with ligands containing a positive charge at residue-20, and that the Arg-20 interaction with Asp-137, observed in the crystal structure of the isolated N-terminal domain of PTH1, is likely to be present in the full length receptor where it provides an important affinity- and potency-generating interaction through a salt bridge.	Aspartic Acid	184-187	parathyroid hormone	Homo sapiens	264-268
25092801-2	2014	), the Regulated upon Activation Normal T cell Expressed and Secreted (RANTES, CCL5)-mediated control of [3H]D-aspartate ([3H]D-ASP) exocytosis elicited by a mild depolarizing stimulus (12 mM KCl) shifted from inhibition to facilitation.	Aspartic Acid	128-131	chemokine (C-C motif) ligand 5	Mus musculus	79-83
26814446-4	2014	However, ELISA results showed that the Arg-Gly-Asp (RGD) activity of adsorbed Fn decreased with the increase of PHEMA thickness.	Aspartic Acid	47-50	fibronectin 1	Homo sapiens	78-80
25092801-8	2014	In spinal cord synaptosomes of EAE mice at 21 d.p.i., when presynaptic defects became evident, the [3H]D-ASP exocytosis elicited by 15 mM KCl was significantly increased when compared to control and it was significantly potentiated by 1 nM CCL5.	Aspartic Acid	105-108	chemokine (C-C motif) ligand 5	Mus musculus	240-244
25092801-10	2014	Differently from controls, however, the CCR1 antagonist BX513 efficiently inhibited on its own [3H]D-ASP exocytosis suggesting that this receptor could have adopted an active conformation.	Aspartic Acid	101-104	chemokine (C-C motif) receptor 1	Mus musculus	40-44
25178721-13	2014	CONCLUSIONS: The interaction of SFN, an anticancer agent, with Abeta was studied using ESI-MS. SFN is found to bind covalently and specifically with the free NH(2) group of N-terminal aspartic acid and the epsilon-amino group of lysine at positions 16 and 28.	Aspartic Acid	184-197	amyloid beta precursor protein	Homo sapiens	63-68
25092801-2	2014	), the Regulated upon Activation Normal T cell Expressed and Secreted (RANTES, CCL5)-mediated control of [3H]D-aspartate ([3H]D-ASP) exocytosis elicited by a mild depolarizing stimulus (12 mM KCl) shifted from inhibition to facilitation.	Aspartic Acid	111-120	chemokine (C-C motif) ligand 5	Mus musculus	71-77
25092801-2	2014	), the Regulated upon Activation Normal T cell Expressed and Secreted (RANTES, CCL5)-mediated control of [3H]D-aspartate ([3H]D-ASP) exocytosis elicited by a mild depolarizing stimulus (12 mM KCl) shifted from inhibition to facilitation.	Aspartic Acid	111-120	chemokine (C-C motif) ligand 5	Mus musculus	79-83
25092801-2	2014	), the Regulated upon Activation Normal T cell Expressed and Secreted (RANTES, CCL5)-mediated control of [3H]D-aspartate ([3H]D-ASP) exocytosis elicited by a mild depolarizing stimulus (12 mM KCl) shifted from inhibition to facilitation.	Aspartic Acid	128-131	chemokine (C-C motif) ligand 5	Mus musculus	71-77
25202010-0	2014	Asp-52 in combination with Asp-398 plays a critical role in ATP hydrolysis of chaperonin GroEL.	Aspartic Acid	0-3	GroEL	Escherichia coli	89-94
25313047-5	2014	Muller glia are deficient for pyruvate kinase (PK) and for aspartate/glutamate carrier 1 (AGC1), a key component of the malate-aspartate shuttle.	Aspartic Acid	59-68	solute carrier family 25 member 12	Homo sapiens	90-94
25202010-3	2014	In the archaeal Group II chaperonin, another aspartate residue, Asp-52 in the corresponding E. coli GroEL, in addition to Asp-398 is also important for ATP hydrolysis.	Aspartic Acid	45-54	GroEL	Escherichia coli	100-105
25202010-0	2014	Asp-52 in combination with Asp-398 plays a critical role in ATP hydrolysis of chaperonin GroEL.	Aspartic Acid	27-30	GroEL	Escherichia coli	89-94
25202010-3	2014	In the archaeal Group II chaperonin, another aspartate residue, Asp-52 in the corresponding E. coli GroEL, in addition to Asp-398 is also important for ATP hydrolysis.	Aspartic Acid	64-67	GroEL	Escherichia coli	100-105
25202010-2	2014	Asp-398 in GroEL is known as one of the critical residues on ATP hydrolysis because GroEL(D398A) mutant is deficient in ATP hydrolysis (&lt;2% of the wild type) but not in ATP binding.	Aspartic Acid	0-3	GroEL	Escherichia coli	11-16
25202010-3	2014	In the archaeal Group II chaperonin, another aspartate residue, Asp-52 in the corresponding E. coli GroEL, in addition to Asp-398 is also important for ATP hydrolysis.	Aspartic Acid	122-125	GroEL	Escherichia coli	100-105
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	28-31	GroEL	Escherichia coli	38-43
25202010-2	2014	Asp-398 in GroEL is known as one of the critical residues on ATP hydrolysis because GroEL(D398A) mutant is deficient in ATP hydrolysis (&lt;2% of the wild type) but not in ATP binding.	Aspartic Acid	0-3	GroEL	Escherichia coli	84-89
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	28-31	GroEL	Escherichia coli	78-83
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	28-31	GroEL	Escherichia coli	78-83
25360085-6	2014	The NMDA-evoked ([(3)H]D-Asp) overflow was partially antagonized by the NMDAR antagonists MK801, D-AP5, 5,7-DCKA and R(-)CPP and unaffected by the GluN2B-NMDAR antagonists Ro256981 and ifenprodil.	Aspartic Acid	25-28	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	147-153
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	28-31	GroEL	Escherichia coli	78-83
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	28-31	GroEL	Escherichia coli	78-83
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	194-197	GroEL	Escherichia coli	78-83
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	194-197	GroEL	Escherichia coli	78-83
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	194-197	GroEL	Escherichia coli	78-83
25202010-4	2014	We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ~ 20% and &lt;0.01% of wild-type GroEL, respectively, indicating that Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis.	Aspartic Acid	194-197	GroEL	Escherichia coli	78-83
25202012-3	2014	The binding to LIMP-2 is not dependent upon a single amino acid, but the interactions of GCase with LIMP-2 are heavily influenced by Asp(399) and the di-isoleucines, Ile(402) and Ile(403).	Aspartic Acid	133-136	scavenger receptor class B member 2	Homo sapiens	100-106
25373904-3	2014	We show here, using a metabolomics-based approach, that cytosolic glutamate derived from the malate-aspartate shuttle upon glucose stimulation underlies the stimulatory effect of incretins and that glutamate uptake into insulin granules mediated by cAMP/PKA signaling amplifies insulin release.	Aspartic Acid	100-109	insulin	Homo sapiens	220-227
25373904-3	2014	We show here, using a metabolomics-based approach, that cytosolic glutamate derived from the malate-aspartate shuttle upon glucose stimulation underlies the stimulatory effect of incretins and that glutamate uptake into insulin granules mediated by cAMP/PKA signaling amplifies insulin release.	Aspartic Acid	100-109	insulin	Homo sapiens	278-285
25327473-0	2014	Methylation of histone H4 at aspartate 24 by protein L-isoaspartate O-methyltransferase (PCMT1) links histone modifications with protein homeostasis.	Aspartic Acid	29-38	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	89-94
25242145-3	2014	CS suppression reduced TCA cycle activity and diverted oxaloacetate, the substrate of CS, into production of the nonessential amino acids aspartate and asparagine.	Aspartic Acid	138-147	citrate synthase	Homo sapiens	0-2
25332048-3	2014	We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69).	Aspartic Acid	18-21	ERCC excision repair 5, endonuclease	Homo sapiens	14-17
25332048-3	2014	We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69).	Aspartic Acid	124-127	ERCC excision repair 5, endonuclease	Homo sapiens	14-17
25332048-3	2014	We found that XPG Asp1104His polymorphism was associated with a significantly increased CRC risk (dominant model: His/His + Asp/His vs. Asp/Asp, adjusted OR = 1.39, 95% CI = 1.14-1.69).	Aspartic Acid	124-127	ERCC excision repair 5, endonuclease	Homo sapiens	14-17
25360085-9	2014	This might be a general feature in different brain areas since a similar nAChR-mediated bolstering of NMDA-induced ([(3)H]D-Asp) overflow was also observed in hippocampal synaptosomes.	Aspartic Acid	124-127	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	73-78
25310961-7	2014	The carriers of homozygous IRS-2 Asp had an increased risk of PCOS compared with the carriers of Gly/Gly (OR 4.08, 95% C.I.	Aspartic Acid	33-36	insulin receptor substrate 2	Homo sapiens	27-32
25242165-1	2014	Copper ATPases, in analogy with other members of the P-ATPase superfamily, contain a catalytic headpiece including an aspartate residue reacting with ATP to form a phosphoenzyme intermediate, and transmembrane helices containing cation-binding sites [TMBS (transmembrane metal-binding sites)] for catalytic activation and cation translocation.	Aspartic Acid	118-127	dynein axonemal heavy chain 8	Homo sapiens	7-13
25310961-13	2014	We further found, the non-obese PCOS patients carried significantly higher frequency of IRS-2 Asp/Asp as compared with the control group (p = 0.004).	Aspartic Acid	94-97	insulin receptor substrate 2	Homo sapiens	88-93
25310961-13	2014	We further found, the non-obese PCOS patients carried significantly higher frequency of IRS-2 Asp/Asp as compared with the control group (p = 0.004).	Aspartic Acid	98-101	insulin receptor substrate 2	Homo sapiens	88-93
25310961-14	2014	A significant effect of interaction of carrying both IRS-1 Gly/Arg and IRS-2 Asp/Asp was also observed in the non-obese PCOS patients (p = 0.003), but not in the obese PCOS patients.	Aspartic Acid	77-80	insulin receptor substrate 2	Homo sapiens	71-76
25310961-14	2014	A significant effect of interaction of carrying both IRS-1 Gly/Arg and IRS-2 Asp/Asp was also observed in the non-obese PCOS patients (p = 0.003), but not in the obese PCOS patients.	Aspartic Acid	81-84	insulin receptor substrate 2	Homo sapiens	71-76
25310961-16	2014	Women with IRS-2 homozygous Asp variant may be considered as a risk factor for PCOS that needs early detection to prevent further complication in the Chinese population from Taiwan.	Aspartic Acid	28-31	insulin receptor substrate 2	Homo sapiens	11-16
25160622-9	2014	A second effector site position, Gly-149 in AtCM1 and Asp-132 in AtCM3, controls amino acid effector specificity in AtCM1 and AtCM3.	Aspartic Acid	54-57	chorismate mutase 3	Arabidopsis thaliana	65-70
25164820-6	2014	Site-directed mutagenesis revealed Asp(92) and Asp(96) as key residues within the C4F6 epitope required for the SOD1-C4F6 binding interaction.	Aspartic Acid	35-38	superoxide dismutase 1, soluble	Mus musculus	112-116
25313689-5	2014	Specifically, positively charged Lys/Arg at position 322 and negatively charged Asp/Glu at position 440 occurred more frequently in CXCR4-using viruses, whereas negatively charged Asp/Glu at position 322 and positively charged Arg at position 440 occurred more frequently in R5 strains.	Aspartic Acid	80-83	C-X-C motif chemokine receptor 4	Homo sapiens	132-137
25160622-9	2014	A second effector site position, Gly-149 in AtCM1 and Asp-132 in AtCM3, controls amino acid effector specificity in AtCM1 and AtCM3.	Aspartic Acid	54-57	chorismate mutase 1	Arabidopsis thaliana	116-121
25164820-6	2014	Site-directed mutagenesis revealed Asp(92) and Asp(96) as key residues within the C4F6 epitope required for the SOD1-C4F6 binding interaction.	Aspartic Acid	47-50	superoxide dismutase 1, soluble	Mus musculus	112-116
25160622-9	2014	A second effector site position, Gly-149 in AtCM1 and Asp-132 in AtCM3, controls amino acid effector specificity in AtCM1 and AtCM3.	Aspartic Acid	54-57	chorismate mutase 3	Arabidopsis thaliana	126-131
25103237-5	2014	Here we complete the functional characterization of this protein family by demonstrating that CCP2 and CCP3 are deglutamylases, with CCP3 being able to hydrolyze aspartic acids with similar efficiency.	Aspartic Acid	162-176	AGBL carboxypeptidase 2	Homo sapiens	94-98
25310149-3	2014	DFG-Asp in and DFG-Asp out homology models of each one were built based on the X-ray structure of c-Met kinase, an enzyme with a closely related sequence.	Aspartic Acid	19-22	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	98-103
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	89-98	solute carrier family 25 member 12	Homo sapiens	119-125
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	89-98	solute carrier family 25 member 12	Homo sapiens	126-130
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	89-98	solute carrier family 25 member 12	Homo sapiens	131-139
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	89-98	solute carrier family 25 member 23	Homo sapiens	214-221
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	89-98	APC regulator of WNT signaling pathway 2	Homo sapiens	222-226
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	89-98	solute carrier family 25 member 23	Homo sapiens	227-235
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	89-98	latexin	Homo sapiens	274-277
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	167-176	solute carrier family 25 member 12	Homo sapiens	119-125
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	167-176	solute carrier family 25 member 12	Homo sapiens	126-130
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	167-176	solute carrier family 25 member 12	Homo sapiens	131-139
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	167-176	solute carrier family 25 member 23	Homo sapiens	214-221
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	167-176	APC regulator of WNT signaling pathway 2	Homo sapiens	222-226
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	167-176	solute carrier family 25 member 23	Homo sapiens	227-235
24820519-4	2014	Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4muM, respectively.	Aspartic Acid	167-176	latexin	Homo sapiens	274-277
25049081-4	2014	Here, we constructed and characterized three catalytic triad mutants of TSP50 and found that all the mutants could significantly depress TSP50-induced cell proliferation and colony formation in vitro and tumor formation in vivo, and the aspartic acid at position 206 in the catalytic triad played a more crucial role than threonine and histidine in this process.	Aspartic Acid	237-250	serine protease 50	Homo sapiens	72-77
25086067-7	2014	TLR signaling did not detectably modulate phosphorylation at these sites but mutation of either residue to phospho-mimetic Asp increased beta2 integrin turnover in podosomes, indicating that phosphorylation at one or both sites establishes permissive conditions for TLR-signaled podosome disassembly.	Aspartic Acid	123-126	hemoglobin, beta adult minor chain	Mus musculus	137-142
24948556-5	2014	Moreover, direct physical interaction of ARR18 with bZIP63 was identified and shown to be dependent on phosphorylation of the conserved aspartate residue in the ARR18 receiver domain.	Aspartic Acid	136-145	response regulator 18	Arabidopsis thaliana	41-46
24948556-5	2014	Moreover, direct physical interaction of ARR18 with bZIP63 was identified and shown to be dependent on phosphorylation of the conserved aspartate residue in the ARR18 receiver domain.	Aspartic Acid	136-145	response regulator 18	Arabidopsis thaliana	161-166
25122770-7	2014	The Hck SH2 domains impinge on the N-terminal region of Nef to stabilize a dimer conformation that exposes Asp-123, a residue critical for Nef function.	Aspartic Acid	107-110	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
25122770-7	2014	The Hck SH2 domains impinge on the N-terminal region of Nef to stabilize a dimer conformation that exposes Asp-123, a residue critical for Nef function.	Aspartic Acid	107-110	S100 calcium binding protein B	Homo sapiens	56-59
25122770-7	2014	The Hck SH2 domains impinge on the N-terminal region of Nef to stabilize a dimer conformation that exposes Asp-123, a residue critical for Nef function.	Aspartic Acid	107-110	S100 calcium binding protein B	Homo sapiens	139-142
25373689-7	2014	For TLR4 (Asp299Gly), the Asp/Asp genotype and the Asp allele were associated with higher risk of developing cervical cancer (OR: 4.95, CI: 1.97-13.22) and (OR: 5.17, CI: 2.11-13.50) respectively.	Aspartic Acid	10-13	toll like receptor 4	Homo sapiens	4-8
25373689-7	2014	For TLR4 (Asp299Gly), the Asp/Asp genotype and the Asp allele were associated with higher risk of developing cervical cancer (OR: 4.95, CI: 1.97-13.22) and (OR: 5.17, CI: 2.11-13.50) respectively.	Aspartic Acid	26-29	toll like receptor 4	Homo sapiens	4-8
25373689-7	2014	For TLR4 (Asp299Gly), the Asp/Asp genotype and the Asp allele were associated with higher risk of developing cervical cancer (OR: 4.95, CI: 1.97-13.22) and (OR: 5.17, CI: 2.11-13.50) respectively.	Aspartic Acid	26-29	toll like receptor 4	Homo sapiens	4-8
25074502-4	2014	To overcome these drawbacks, we developed novel PLGA-pMS by incorporating bovine serum albumin (BSA) loaded chitosan microspheres (CS-MS) in Gly-Arg-Gly-Asp-Ser-Pro-Cys (GRGDSPC) modified PLGA-pMS (CS-MS/PLGA-pMS).	Aspartic Acid	153-156	albumin	Homo sapiens	81-94
25274726-5	2014	Interestingly, several of the tumor-promoting functions of CtsZ were not dependent on its described catalytic activity but instead were mediated via the Arg-Gly-Asp (RGD) motif in the enzyme prodomain, which regulated interactions with integrins and the extracellular matrix.	Aspartic Acid	161-164	cathepsin Z	Homo sapiens	59-63
25116801-2	2014	The mutation affects a conserved aspartic acid in position 244 (p.Asp244Gly) located in one of the high-affinity Ca(2+) -binding sites of CASQ1 and alters the kinetics of Ca(2+) release in muscle fibers.	Aspartic Acid	33-46	calsequestrin 1	Homo sapiens	138-143
24178590-8	2014	When FN molecules adsorbed onto the surfaces of TiNTs, their RGD (Arg-Gly-Asp) sites were easily exposed to outside and more likely to bond with the fibronectin receptors, in turn regulating the cellular behaviors.	Aspartic Acid	74-77	fibronectin 1	Homo sapiens	5-7
24178590-8	2014	When FN molecules adsorbed onto the surfaces of TiNTs, their RGD (Arg-Gly-Asp) sites were easily exposed to outside and more likely to bond with the fibronectin receptors, in turn regulating the cellular behaviors.	Aspartic Acid	74-77	fibronectin 1	Homo sapiens	149-160
25103237-5	2014	Here we complete the functional characterization of this protein family by demonstrating that CCP2 and CCP3 are deglutamylases, with CCP3 being able to hydrolyze aspartic acids with similar efficiency.	Aspartic Acid	162-176	AGBL carboxypeptidase 3	Homo sapiens	103-107
25103237-5	2014	Here we complete the functional characterization of this protein family by demonstrating that CCP2 and CCP3 are deglutamylases, with CCP3 being able to hydrolyze aspartic acids with similar efficiency.	Aspartic Acid	162-176	AGBL carboxypeptidase 3	Homo sapiens	133-137
25162936-4	2014	In the present work, we investigated the tautomeric equilibrium for the external aldimine state of PLP aspartate (PLP-Asp) Schiff base in the active site of aspartate aminotransferase (AspAT) using combined quantum mechanical and molecular mechanical simulations.	Aspartic Acid	103-112	pyridoxal phosphatase	Homo sapiens	99-102
24950454-1	2014	There occur two rare variations, Asp(D)478Asn(N) and Asp(D)478Glu(E), in the putative cytoplasmic amphipathic alpha-helices of human nicotinic acetylcholine receptor (nAChR) alpha2 subunit as a result of mutation in the 1st (G   A: rs141072985) and 3rd (C   A: rs56344740) nucleotide of its 478th triplet codon (GAC).	Aspartic Acid	33-36	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	133-165
24950454-1	2014	There occur two rare variations, Asp(D)478Asn(N) and Asp(D)478Glu(E), in the putative cytoplasmic amphipathic alpha-helices of human nicotinic acetylcholine receptor (nAChR) alpha2 subunit as a result of mutation in the 1st (G   A: rs141072985) and 3rd (C   A: rs56344740) nucleotide of its 478th triplet codon (GAC).	Aspartic Acid	33-36	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	167-172
24719229-2	2014	This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1 (IFIH1) and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 and systemic lupus erythematosus (SLE), including the phenotypes lupus nephritis and malar rash, as well as the presence of autoantibodies against nucleic acid-containing complexes.	Aspartic Acid	171-174	toll like receptor 3	Homo sapiens	87-107
24719229-2	2014	This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1 (IFIH1) and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 and systemic lupus erythematosus (SLE), including the phenotypes lupus nephritis and malar rash, as well as the presence of autoantibodies against nucleic acid-containing complexes.	Aspartic Acid	171-174	interferon induced with helicase C domain 1	Homo sapiens	154-159
24719229-2	2014	This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1 (IFIH1) and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 and systemic lupus erythematosus (SLE), including the phenotypes lupus nephritis and malar rash, as well as the presence of autoantibodies against nucleic acid-containing complexes.	Aspartic Acid	183-186	toll like receptor 3	Homo sapiens	87-107
24719229-2	2014	This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1 (IFIH1) and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 and systemic lupus erythematosus (SLE), including the phenotypes lupus nephritis and malar rash, as well as the presence of autoantibodies against nucleic acid-containing complexes.	Aspartic Acid	183-186	interferon induced with helicase C domain 1	Homo sapiens	154-159
25162936-4	2014	In the present work, we investigated the tautomeric equilibrium for the external aldimine state of PLP aspartate (PLP-Asp) Schiff base in the active site of aspartate aminotransferase (AspAT) using combined quantum mechanical and molecular mechanical simulations.	Aspartic Acid	103-112	pyridoxal phosphatase	Homo sapiens	114-117
25049229-8	2014	We suggest that a surface of GRK2, including Leu(4), Val(7), Leu(8), Val(11), and Ser(12), directly interacts with receptors, whereas residues such as Asp(10), Tyr(13), Ala(16), Met(17), Gly(475), Val(477), and Ile(485) are more important for kinase domain closure and activation.	Aspartic Acid	151-154	G protein-coupled receptor kinase 2	Homo sapiens	29-33
25075548-6	2014	To improve the tumor specificity of the system, cyclic arginine-glycine-aspartic acid (cRGD) tripeptide as the receptor to integrin alphavbeta3 overexpressed cancer cells was further incorporated to the surface of the NPs.	Aspartic Acid	72-85	integrin subunit alpha V	Homo sapiens	123-143
25020226-7	2014	The leucine and valine residues insert into the binding groove while the first residue, asparagine, tethers the peptide via an interaction with CPE"s aspartate 225 and the two prolines are required to maintain the tight turn conformation.	Aspartic Acid	150-159	cpe	Clostridium perfringens	144-147
25002582-11	2014	The Ser   Asp mutant had enhanced protein turnover compared with the Ser   Ala mutant and wild type tomosyn-2.	Aspartic Acid	10-13	syntaxin binding protein 5L	Homo sapiens	100-109
24969463-8	2014	Monocrotophos interacts most strongly with the Trp-108 and Asp-52 of lysozyme.	Aspartic Acid	59-62	lysozyme	Homo sapiens	69-77
25089939-7	2014	The OGG1 326 Ser/Cys and XPD 312 Asp/Asn heterozygous genotypes were inversely associated with cancer risk (OR [95% CI] = 0.69 [0.50-0.95] and 1.35 [1.0-1.82], respectively).	Aspartic Acid	33-36	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	25-28
25089939-9	2014	CONCLUSIONS: Among four DNA repair gene polymorphisms, the OGG1 326 Ser/Cys and XPD 312 Asp/Asn heterozygous genotypes might be recognized as potential genetic markers modifying susceptibility to bladder cancer in Belarus.	Aspartic Acid	88-91	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	80-83
25168908-7	2014	Mutation of two aspartate residues to uncharged alanine amino acids (D110/112A) in the first extracellular loop of Orai1 significantly attenuated both the inhibition of ICRAC by external acidic pH as well as its facilitation by alkaline conditions.	Aspartic Acid	16-25	ORAI calcium release-activated calcium modulator 1	Homo sapiens	115-120
25029243-12	2014	Subsequent studies in Neo1 mice showed attenuated serum levels of lactate dehydrogenase, aspartate, alanine, and proinflammatory cytokines during hepatic ischemia and reperfusion injury.	Aspartic Acid	89-98	neogenin	Mus musculus	22-26
25038572-9	2014	The analysis of the model structure of N212D APE1 provides evidence for alternate hydrogen bonding between Asn-212 and Asp-210 residues, whereas N212A possesses an extended active site pocket due to Asn removal.	Aspartic Acid	119-122	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	45-49
24690400-7	2014	For Asp299Gly polymorphism of the TLR4 gene we found that there were no control individuals who were homozygous carriers of the Gly/Gly genotype, and the risk for SSPE increased at approximately 4.7 fold for the heterozygous carriers of the Asp/Gly genotype (OR 4.727, 95%-CI 1.192-18.742; P=0.01), when compared to healthy controls.	Aspartic Acid	4-7	toll like receptor 4	Homo sapiens	34-38
25017908-6	2014	This segment, ascribed chaperoning charge-interactions with insulin, suggests that the insulin interactions constitute a basic function, although largely shifting from Glu to Asp residues in C-peptides of lower life forms.	Aspartic Acid	175-178	insulin	Homo sapiens	60-67
24753307-8	2014	This conclusion is partially supported by studies on HA2 variant peptides in which these positions were altered to aspartic acid.	Aspartic Acid	115-128	keratin 32	Homo sapiens	53-56
25119859-3	2014	Treatments of ASP significantly induced the expression of phase II enzymes including NAD(P)H: quinoneoxidoreductase 1, catalase, glutathione peroxidase, and superoxide dismutase in the cells and mice.	Aspartic Acid	14-17	catalase	Mus musculus	58-127
25119859-5	2014	APAP-induced hepatotoxic markers including AST and ALT in mice were inhibited by ASP administration.	Aspartic Acid	81-84	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	43-46
25119859-5	2014	APAP-induced hepatotoxic markers including AST and ALT in mice were inhibited by ASP administration.	Aspartic Acid	81-84	glutamic pyruvic transaminase, soluble	Mus musculus	51-54
24939847-2	2014	Subsequent post-translational modification of Met to Asp was reported in gamma subunits of human fetal Hb Toms River (gamma67(E11)Val   Met) and beta subunits of adult Hb (HbA) Bristol-Alesha (beta67(E11)Val   Met) that were associated with hemolytic anemia.	Aspartic Acid	53-56	keratin 90, pseudogene	Homo sapiens	172-175
24106212-7	2014	For example, DnaJB13 is predicted to be a non-functional Hsp40 in humans, mouse, and zebrafish due to a corrupted histidine-proline-aspartic acid (HPD) motif, while the coelacanth homolog has an intact HPD.	Aspartic Acid	132-145	DnaJ heat shock protein family (Hsp40) member B13	Homo sapiens	13-20
24106212-7	2014	For example, DnaJB13 is predicted to be a non-functional Hsp40 in humans, mouse, and zebrafish due to a corrupted histidine-proline-aspartic acid (HPD) motif, while the coelacanth homolog has an intact HPD.	Aspartic Acid	132-145	DnaJ heat shock protein family (Hsp40) member B1	Homo sapiens	57-62
25516835-7	2014	Quisqualate activated only SmGluCl-2 whereas l-aspartate activated only AVR-14B GluCls.	Aspartic Acid	45-56	Ig-like domain-containing protein;Neur_chan_LBD domain-containing protein;Uncharacterized protein	Caenorhabditis elegans	72-78
25017908-6	2014	This segment, ascribed chaperoning charge-interactions with insulin, suggests that the insulin interactions constitute a basic function, although largely shifting from Glu to Asp residues in C-peptides of lower life forms.	Aspartic Acid	175-178	insulin	Homo sapiens	87-94
25089524-5	2014	Thus, we generated a punctual mutant form of RBF in which the aspartate of the TELD site is replaced by an alanine.	Aspartic Acid	62-71	Ribonuclear protein at 97D	Drosophila melanogaster	45-48
24916029-3	2014	To develop a synthetic strategy, we performed docking studies of lead compound 4 bound to 5-HT2B and 5-HT7 receptors, and observed that the carbonyl guanidine group forms a tight interaction network with an active center Asp (D135:5-HT2B, D162:5-HT7), Tyr (Y370:5-HT2B, Y374:5-HT7) and aromatic residue (W131:5-HT2B, F158:5-HT7).	Aspartic Acid	221-224	5-hydroxytryptamine receptor 2B	Cavia porcellus	90-96
24916029-3	2014	To develop a synthetic strategy, we performed docking studies of lead compound 4 bound to 5-HT2B and 5-HT7 receptors, and observed that the carbonyl guanidine group forms a tight interaction network with an active center Asp (D135:5-HT2B, D162:5-HT7), Tyr (Y370:5-HT2B, Y374:5-HT7) and aromatic residue (W131:5-HT2B, F158:5-HT7).	Aspartic Acid	221-224	5-hydroxytryptamine receptor 2B	Cavia porcellus	231-237
24916029-3	2014	To develop a synthetic strategy, we performed docking studies of lead compound 4 bound to 5-HT2B and 5-HT7 receptors, and observed that the carbonyl guanidine group forms a tight interaction network with an active center Asp (D135:5-HT2B, D162:5-HT7), Tyr (Y370:5-HT2B, Y374:5-HT7) and aromatic residue (W131:5-HT2B, F158:5-HT7).	Aspartic Acid	221-224	5-hydroxytryptamine receptor 2B	Cavia porcellus	231-237
24916029-3	2014	To develop a synthetic strategy, we performed docking studies of lead compound 4 bound to 5-HT2B and 5-HT7 receptors, and observed that the carbonyl guanidine group forms a tight interaction network with an active center Asp (D135:5-HT2B, D162:5-HT7), Tyr (Y370:5-HT2B, Y374:5-HT7) and aromatic residue (W131:5-HT2B, F158:5-HT7).	Aspartic Acid	221-224	5-hydroxytryptamine receptor 2B	Cavia porcellus	231-237
24928228-5	2014	This study thus explored whether JAK3 regulates glutamate transporters EAAT1-4, carriers accomplishing transport of glutamate and aspartate in a variety of cells including intestinal cells, renal cells, glial cells, and neurons.	Aspartic Acid	130-139	Janus kinase 3	Mus musculus	33-37
25158198-2	2014	DPP has a disordered structure, rich in glutamic acid, aspartic acid and phosphorylated serine/threonine residues.	Aspartic Acid	55-68	dentin sialophosphoprotein	Homo sapiens	0-3
24928228-5	2014	This study thus explored whether JAK3 regulates glutamate transporters EAAT1-4, carriers accomplishing transport of glutamate and aspartate in a variety of cells including intestinal cells, renal cells, glial cells, and neurons.	Aspartic Acid	130-139	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	71-78
24850736-2	2014	Here we show that changing a single amino acid (S442D) from serine in type 2 EBNA-2 to the aspartate found in type 1 EBNA-2 confers a type 1 growth phenotype in a lymphoblastoid cell line growth maintenance assay.	Aspartic Acid	91-100	EBNA-2	Human gammaherpesvirus 4	77-83
24850736-2	2014	Here we show that changing a single amino acid (S442D) from serine in type 2 EBNA-2 to the aspartate found in type 1 EBNA-2 confers a type 1 growth phenotype in a lymphoblastoid cell line growth maintenance assay.	Aspartic Acid	91-100	EBNA-2	Human gammaherpesvirus 4	117-123
24850736-9	2014	Here we identify a single amino acid (Ser in type 1 EBV, Asp in type 2 EBV) of EBNA-2 that determines the superior ability of type 1 EBNA-2 to induce a key group of cell genes and the EBV LMP-1 gene, which mediate the growth advantage of B cells infected with type 1 EBV.	Aspartic Acid	57-60	EBNA-2	Human gammaherpesvirus 4	79-85
24850736-9	2014	Here we identify a single amino acid (Ser in type 1 EBV, Asp in type 2 EBV) of EBNA-2 that determines the superior ability of type 1 EBNA-2 to induce a key group of cell genes and the EBV LMP-1 gene, which mediate the growth advantage of B cells infected with type 1 EBV.	Aspartic Acid	57-60	EBNA-2	Human gammaherpesvirus 4	133-139
24850736-9	2014	Here we identify a single amino acid (Ser in type 1 EBV, Asp in type 2 EBV) of EBNA-2 that determines the superior ability of type 1 EBNA-2 to induce a key group of cell genes and the EBV LMP-1 gene, which mediate the growth advantage of B cells infected with type 1 EBV.	Aspartic Acid	57-60	LMP1	Human gammaherpesvirus 4	188-193
24177919-5	2014	In the alpha7 nAChR, it has been found that the ECD contains a ring of ten aspartates (two per subunit) that is believed to face the lumen of the pore and could attract cations for permeation.	Aspartic Acid	75-85	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	14-19
24177919-6	2014	Using mutagenesis and a combination of electrophysiology and imaging techniques, we tested the possible involvement of these aspartate residues in the calcium permeability of the rat alpha7 nAChR.	Aspartic Acid	125-134	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	190-195
24177919-7	2014	We found that one of these residues (the aspartate at position 44) appears to be essential since mutating it to alanine resulted in a decrease in amplitude for both whole cell and single-channel responses and in the complete disappearance of detectable calcium changes in most cells, which indicates that the ECD of the alpha7 nAChR plays a key role in calcium permeation.	Aspartic Acid	41-50	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	327-332
24752529-3	2014	ASP markedly decreased hepcidin expression by suppressing the expression of JAK1/2, phospho-JAK1/2, phospho-SMAD1/5/8, phospho-ERK1/2, and promoting the expression of SMAD7 in the liver.	Aspartic Acid	0-3	hepcidin antimicrobial peptide	Rattus norvegicus	23-31
25110155-1	2014	Citrin is the liver-type aspartate/glutamate carrier isoform 2 (AGC2) encoded by SLC25A13 gene, playing important roles in the urea cycle and the malate-aspartate shuttle.	Aspartic Acid	25-34	solute carrier family 25 member 13	Homo sapiens	0-6
25110155-1	2014	Citrin is the liver-type aspartate/glutamate carrier isoform 2 (AGC2) encoded by SLC25A13 gene, playing important roles in the urea cycle and the malate-aspartate shuttle.	Aspartic Acid	25-34	solute carrier family 25 member 13	Homo sapiens	81-89
24977939-2	2014	CD is characterized by mutations in the gene encoding aspartoacylase (ASPA), the substrate enzyme that hydrolyzes N-acetylaspartic acid (NAA) to acetate and aspartate.	Aspartic Acid	157-166	aspartoacylase	Homo sapiens	70-74
24752529-4	2014	These findings suggest that ASP can prevent the janus-kinase (JAK), son of mother against decapentaplegic (SMAD) and extracellular signal-regulated kinase (ERK) pathways to down-regulate hepcidin expression in IDA rats, and may be useful for the treatments of diseases induced by hepcidin over-expression.	Aspartic Acid	28-31	Eph receptor B1	Rattus norvegicus	117-154
24752529-4	2014	These findings suggest that ASP can prevent the janus-kinase (JAK), son of mother against decapentaplegic (SMAD) and extracellular signal-regulated kinase (ERK) pathways to down-regulate hepcidin expression in IDA rats, and may be useful for the treatments of diseases induced by hepcidin over-expression.	Aspartic Acid	28-31	Eph receptor B1	Rattus norvegicus	156-159
24752529-4	2014	These findings suggest that ASP can prevent the janus-kinase (JAK), son of mother against decapentaplegic (SMAD) and extracellular signal-regulated kinase (ERK) pathways to down-regulate hepcidin expression in IDA rats, and may be useful for the treatments of diseases induced by hepcidin over-expression.	Aspartic Acid	28-31	hepcidin antimicrobial peptide	Rattus norvegicus	187-195
24752529-4	2014	These findings suggest that ASP can prevent the janus-kinase (JAK), son of mother against decapentaplegic (SMAD) and extracellular signal-regulated kinase (ERK) pathways to down-regulate hepcidin expression in IDA rats, and may be useful for the treatments of diseases induced by hepcidin over-expression.	Aspartic Acid	28-31	hepcidin antimicrobial peptide	Rattus norvegicus	280-288
25034608-8	2014	The Asp-Phe-Gly (DFG) and His-Arg-Asp (HRD) conserved kinase motif analysis showed the importance of these motifs in IRAK4 kinase activation.	Aspartic Acid	4-7	interleukin 1 receptor associated kinase 4	Homo sapiens	117-122
25606432-4	2014	L23a is highly basic, containing a combined 45 Arg, Lys, and His residues and only 14 Asp and Glu residues.	Aspartic Acid	86-89	ribosomal protein L23a	Homo sapiens	0-4
24849604-11	2014	The inverse staurosporine effect on aspartate versus alanine substitutions reveals a cross-talk between different phosphorylation sites of KCC2.	Aspartic Acid	36-45	solute carrier family 12 member 5	Homo sapiens	139-143
25024628-8	2014	RESULTS: The APE1 148 Glu/Glu genotype was significantly associated with an increased risk of colorectal cancer (OR = 2.411, 95%CI: 1.497-3.886, P &lt; 0.001 relative to Asp/Asp genotype).	Aspartic Acid	170-173	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	13-17
25024628-8	2014	RESULTS: The APE1 148 Glu/Glu genotype was significantly associated with an increased risk of colorectal cancer (OR = 2.411, 95%CI: 1.497-3.886, P &lt; 0.001 relative to Asp/Asp genotype).	Aspartic Acid	174-177	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	13-17
24847060-7	2014	The negative charge of two aspartate residues within this stretch is crucial for lipase activity of Tgl3p.	Aspartic Acid	27-36	bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase	Saccharomyces cerevisiae S288C	100-105
24912149-6	2014	We identify four Hv1 residues involved in the binding: aspartate 112, phenylalanine 150, serine 181, and arginine 211.	Aspartic Acid	55-64	hydrogen voltage gated channel 1	Homo sapiens	17-20
25214272-4	2014	The conducted researches results have shown reliably higher frequency of heterozygous genotype Asp/Gly TLR-4 in patients with grippe (12,69%) and grippe-associated pneumonia (14,28%) compared with population control (3,33%).	Aspartic Acid	95-98	toll like receptor 4	Homo sapiens	103-108
24874604-6	2014	Interestingly, mutation of this serine to alanine (S106A), a non-phosphorylatable analogue, greatly diminished the ability of Asef2 to activate Rac, while a phosphomimetic mutation (serine to aspartic acid, S106D) enhanced Rac activation.	Aspartic Acid	192-205	spermatogenesis associated 13	Homo sapiens	126-131
24944642-8	2014	In addition, the plasma NOx concentration in the eNOS Glu/Glu homozygote carriers (129.66+-59.15 mumol/l) was significantly lower compared with the Asp allele carriers (169.84+- 55.18 mumol/l; P=0.010).	Aspartic Acid	148-151	nitric oxide synthase 3	Homo sapiens	49-53
24867954-13	2014	Dimerization is essential for E25 to exert its catalytic activity by keeping the accurate orientation of the catalytic Asp(282) within the catalytic triad.	Aspartic Acid	119-122	integral membrane protein 2C	Homo sapiens	30-33
24681163-9	2014	Additional substitution of the 11th Gly with Asp was found by comparison with human sEH which has phosphatase activity, but the Xenopus sEH mutant G11D prepared as mutant 2 did not have phosphatase activity.	Aspartic Acid	45-48	epoxide hydrolase 2	Homo sapiens	84-87
25214272-7	2014	It has been established that there is the increased risk of grippe development for persons with Asp/Gly TLR-4 genotype and TLR-2, TLR-3, TLR-4 mutant genotypes combinations; there is the increased risk of grippe-associated pneumonia for patients with mutant homozygous genotype Phe/Phe TLR-3.	Aspartic Acid	96-99	toll like receptor 4	Homo sapiens	104-109
24741082-2	2014	Mutation of these phosphoacceptor sites to either alanine or aspartic acid showed only a minor effect on both activities but revealed the presence of other phosphoacceptor sites that might be involved in regulating NEP activity.	Aspartic Acid	61-74	membrane metalloendopeptidase	Homo sapiens	215-218
24375788-0	2014	In vivo analysis of Arg-Gly-Asp sequence/integrin alpha5beta1-mediated signal involvement in embryonic enchondral ossification by exo utero development system.	Aspartic Acid	28-31	5'-3' exoribonuclease 1	Mus musculus	130-133
24375788-3	2014	The purpose of this study is to elucidate in vivo the roles of the integrin alpha5beta1-mediated signal through the Arg-Gly-Asp (RGD) sequence in the cell-extracellular matrix (ECM) interaction in embryonic enchondral ossification by an exo utero development system.	Aspartic Acid	124-127	5'-3' exoribonuclease 1	Mus musculus	237-240
24942835-6	2014	The active site cavity is hydrophilic and widely open to the cytoplasm with a magnesium ion surrounded by four highly conserved aspartate residues from helices TM2 and TM3.	Aspartic Acid	128-137	tropomyosin 3	Homo sapiens	168-171
24983862-6	2014	ASP was used to examine the intrinsic flexibility of the ATP-binding pocket for CDK5/p25, CDK5 and GSK3beta where it is shown to be capable of inducing significant conformational changes when compared with X-ray crystal structures.	Aspartic Acid	0-3	cyclin dependent kinase 5	Homo sapiens	90-94
24983862-6	2014	ASP was used to examine the intrinsic flexibility of the ATP-binding pocket for CDK5/p25, CDK5 and GSK3beta where it is shown to be capable of inducing significant conformational changes when compared with X-ray crystal structures.	Aspartic Acid	0-3	glycogen synthase kinase 3 alpha	Homo sapiens	99-107
24892992-5	2014	Mutational analysis of PHLPP2 reveals an unusual active site architecture compared to the canonical architecture of PP2C phosphatases and identifies key acidic residues (Asp 806, Glu 989, and Asp 1024) and bulky aromatic residues (Phe 783 and Phe 808) whose mutation impairs activity.	Aspartic Acid	170-173	PH domain and leucine rich repeat protein phosphatase 2	Homo sapiens	23-29
24753048-2	2014	Alanine (T62A) or aspartate (T62D) mutagenesis of Thr62 revealed T62D-human (h)DAT partitions in a predominately efflux-preferring conformation.	Aspartic Acid	18-27	solute carrier family 6 member 3	Homo sapiens	79-82
24753048-8	2014	Utilization of the fluorescent DAT substrate ASP(+) [4-(4-(dimethylamino)styryl)-N-methylpyridinium] revealed that T62D-hDAT accumulates substrate in human embryonic kidney (HEK)-293 cells when the substrate is not subject to efflux.	Aspartic Acid	45-51	solute carrier family 6 member 3	Homo sapiens	31-34
24928858-5	2014	p53 in which Ser15 is substituted by alanine (S15A) fails to mediate p53-dependent transcription or growth arrest but can be rescued by substitution with aspartate (S15D: a phospho-mimic).	Aspartic Acid	154-163	tumor protein p53	Homo sapiens	0-3
25155931-1	2014	AIM: Determine whether SNPs of OPRM1 118A&gt;G (asn(40)asp), COMT 472G&gt;A (val(158)met) and ARRB2 8622C&gt;T are associated with morphine rescue in newborns on mechanical ventilation.	Aspartic Acid	55-58	opioid receptor mu 1	Homo sapiens	31-36
24983862-6	2014	ASP was used to examine the intrinsic flexibility of the ATP-binding pocket for CDK5/p25, CDK5 and GSK3beta where it is shown to be capable of inducing significant conformational changes when compared with X-ray crystal structures.	Aspartic Acid	0-3	cyclin dependent kinase 5	Homo sapiens	80-84
24983862-6	2014	ASP was used to examine the intrinsic flexibility of the ATP-binding pocket for CDK5/p25, CDK5 and GSK3beta where it is shown to be capable of inducing significant conformational changes when compared with X-ray crystal structures.	Aspartic Acid	0-3	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	85-88
24892992-5	2014	Mutational analysis of PHLPP2 reveals an unusual active site architecture compared to the canonical architecture of PP2C phosphatases and identifies key acidic residues (Asp 806, Glu 989, and Asp 1024) and bulky aromatic residues (Phe 783 and Phe 808) whose mutation impairs activity.	Aspartic Acid	192-195	PH domain and leucine rich repeat protein phosphatase 2	Homo sapiens	23-29
24467436-9	2014	NAT enzymes act through a catalytic triad of Cys, His and Asp with the architecture of the active site-modulating specificity.	Aspartic Acid	58-61	bromodomain containing 2	Homo sapiens	0-3
24690260-0	2014	An aspartate in the second extracellular loop of the alpha(1B) adrenoceptor regulates agonist binding.	Aspartic Acid	3-12	adrenoceptor alpha 1B	Homo sapiens	53-75
24901225-4	2014	S1333 mutations to glycine, arginine, or lysine also create a hyperactive kinase, while mutation to aspartic acid decreases ATR activity.	Aspartic Acid	100-113	ATR serine/threonine kinase	Homo sapiens	124-127
24892779-8	2014	Taken together, the results showed that Ca-ASP possessed similar antithrombotic activity as ASP but without the side effect associated with ASP, and the underlying mechanism may center on inhibiting COX-2 without inhibiting COX-1, and thus favouring the production of PGE2, the prostaglandin that plays a vital role in the suppression of platelet aggregation and thrombosis, as well as in the repair of gastric damage.	Aspartic Acid	43-46	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	199-204
24690260-4	2014	We have generated mutants of the alpha1B adrenoceptor replacing the charged aspartate, D191, as well as a potential interaction partner, K331, with uncharged alanines to observe effects on ligand binding and receptor activation.	Aspartic Acid	76-85	adrenoceptor alpha 1B	Homo sapiens	33-53
24801391-7	2014	In nonstimulated adipocytes, the Asp mutation led to decreased LD association and basal lipolytic activity of ATGL, whereas the Ala mutation produced opposite effects.	Aspartic Acid	33-36	patatin like phospholipase domain containing 2	Homo sapiens	110-114
24801391-8	2014	Moreover, the LD translocation of ATGL upon beta-adrenergic stimulation was also compromised by the Asp mutation.	Aspartic Acid	100-103	patatin like phospholipase domain containing 2	Homo sapiens	34-38
24801391-9	2014	In accord with these findings, the Ala mutation promoted and the Asp mutation attenuated the capacity of ATGL to mediate lipolysis in adipocytes under both basal and stimulated conditions.	Aspartic Acid	65-68	patatin like phospholipase domain containing 2	Homo sapiens	105-109
24731805-8	2014	The MCA1 mutation resulted in substitution of asparagine (N) with aspartic acid (D) at position 164 (MCA1(N164D)).	Aspartic Acid	66-79	Ca(2+)-dependent cysteine protease MCA1	Saccharomyces cerevisiae S288C	4-8
24483321-0	2014	A new unstable variant of the fetal hemoglobin HBG2 gene: Hb F-Turritana [(G) gamma64(E8)Gly Asp, HBG2:c.194G&gt;A] found in cis to the Hb F-Sardinia gene [(A) gamma(E19)Ile Thr, HBG1:c.227T&gt;C].	Aspartic Acid	93-96	hemoglobin subunit gamma 2	Homo sapiens	47-51
24483321-3	2014	After HBG2 gene sequencing, the G to A transversion at codon 64, position eight of the E helix, was found, which corresponds to the Asp for Gly amino acid substitution.	Aspartic Acid	132-135	hemoglobin subunit gamma 2	Homo sapiens	6-10
24731805-8	2014	The MCA1 mutation resulted in substitution of asparagine (N) with aspartic acid (D) at position 164 (MCA1(N164D)).	Aspartic Acid	66-79	Ca(2+)-dependent cysteine protease MCA1	Saccharomyces cerevisiae S288C	101-105
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Aspartic Acid	135-138	DExH-box helicase 29	Homo sapiens	172-177
23775820-8	2014	Also, the simulations revealed different conformations of fibronectin on each scaffold type after adsorption, with the arginine-glycine-aspartic acid sequence appearing most accessible on the aminated scaffolds.	Aspartic Acid	136-149	fibronectin 1	Homo sapiens	58-69
24767309-0	2014	Aspartate alleviates liver injury and regulates mRNA expressions of TLR4 and NOD signaling-related genes in weaned pigs after lipopolysaccharide challenge.	Aspartic Acid	0-9	toll like receptor 4	Sus scrofa	68-72
24711368-1	2014	Dnmt2 enzymes are conserved in eukaryotes, where they methylate C38 of tRNA-Asp with high activity.	Aspartic Acid	76-79	tRNA aspartic acid methyltransferase 1	Homo sapiens	0-5
24306268-0	2014	A meta-analysis of the relationship between aspartic acid (D)-repeat polymorphisms in asporin and osteoarthritis susceptibility.	Aspartic Acid	44-57	asporin	Homo sapiens	86-93
24713504-4	2014	In vivod-Asp administration induced serum LH release, causing an indirect increase of androstenedione and testosterone levels by enhancing steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase/D5-D4 isomerases (3beta-HSD) mRNA levels.	Aspartic Acid	9-12	steroidogenic acute regulatory protein	Rattus norvegicus	139-177
24713504-4	2014	In vivod-Asp administration induced serum LH release, causing an indirect increase of androstenedione and testosterone levels by enhancing steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase/D5-D4 isomerases (3beta-HSD) mRNA levels.	Aspartic Acid	9-12	steroidogenic acute regulatory protein	Rattus norvegicus	179-183
24713504-4	2014	In vivod-Asp administration induced serum LH release, causing an indirect increase of androstenedione and testosterone levels by enhancing steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase/D5-D4 isomerases (3beta-HSD) mRNA levels.	Aspartic Acid	9-12	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	242-249
24989278-3	2014	Pro-apoptosis effect of E.coli-L-Asp and Erwinia-L-Asp on REH and Jurkat cell lines was also determined by flow cytometry with Annexin V/PI double staining.	Aspartic Acid	31-36	annexin A5	Homo sapiens	127-136
24989278-7	2014	However, after treatment of REN and Jurkat cells with 2 kind of L-Asp for 48 hours, the inhibition of cell proliferation and apoptosis rates were not significantly different between the 2 L-Asp drugs (P &gt; 0.05).	Aspartic Acid	64-69	renin	Homo sapiens	28-31
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Aspartic Acid	135-138	helicase for meiosis 1	Homo sapiens	227-235
24738963-2	2014	Here, we report that a largely hydrated, conserved, buried aspartic acid in the water cavity modulates the dynamics of the interacting loops of yeast thioredoxin 1 (yTrx1).	Aspartic Acid	59-72	thioredoxin TRX1	Saccharomyces cerevisiae S288C	165-170
24706745-4	2014	In sharp contrast, mice homozygous for a point mutation in the Prss8 gene, which causes the substitution of the active site serine within the catalytic histidine-aspartate-serine triad with alanine and renders prostasin catalytically inactive (Prss8(Cat-/Cat-) mice), develop barrier function and are healthy when followed for up to 20 weeks.	Aspartic Acid	162-171	protease, serine 8 (prostasin)	Mus musculus	63-68
24692540-8	2014	The Propeller residue Asp-150, which normally coordinates Arg of the ligand Arg-Gly-Asp motif, formed contacts with Arg-54 of the Fab that were expected to reduce soluble FN10 binding to cellular alphaVbeta3 complexed with 17E6.	Aspartic Acid	22-25	FA complementation group B	Homo sapiens	130-133
24692540-8	2014	The Propeller residue Asp-150, which normally coordinates Arg of the ligand Arg-Gly-Asp motif, formed contacts with Arg-54 of the Fab that were expected to reduce soluble FN10 binding to cellular alphaVbeta3 complexed with 17E6.	Aspartic Acid	84-87	FA complementation group B	Homo sapiens	130-133
24828203-2	2014	The MALDI-ISD spectra of bovine serum albumin (BSA), myoglobin and thioredoxin show discontinuous intense ion peaks originating from one-side preferential cleavage at the N-Calpha bond of Xxx-Asp, Xxx-Asn, Xxx-Cys and Gly-Xxx residues.	Aspartic Acid	192-195	albumin	Homo sapiens	32-45
24828203-2	2014	The MALDI-ISD spectra of bovine serum albumin (BSA), myoglobin and thioredoxin show discontinuous intense ion peaks originating from one-side preferential cleavage at the N-Calpha bond of Xxx-Asp, Xxx-Asn, Xxx-Cys and Gly-Xxx residues.	Aspartic Acid	192-195	thioredoxin	Homo sapiens	67-78
24781523-6	2014	In contrast, separase-associated securin is destabilized by introduction of phosphorylation-mimetic aspartates or extinction of separase-associated PP2A activity.	Aspartic Acid	100-110	extra spindle pole bodies like 1, separase	Homo sapiens	13-21
24781523-6	2014	In contrast, separase-associated securin is destabilized by introduction of phosphorylation-mimetic aspartates or extinction of separase-associated PP2A activity.	Aspartic Acid	100-110	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	33-40
24781523-7	2014	G2- or prometaphase-arrested cells suffer from unscheduled activation of separase when endogenous securin is replaced by aspartate-mutant securin.	Aspartic Acid	121-130	extra spindle pole bodies like 1, separase	Homo sapiens	73-81
24781523-7	2014	G2- or prometaphase-arrested cells suffer from unscheduled activation of separase when endogenous securin is replaced by aspartate-mutant securin.	Aspartic Acid	121-130	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	138-145
24738963-3	2014	It is well-established that the aspartic acid, Asp24 for yTrx1, works as a proton acceptor in the reduction of the target protein.	Aspartic Acid	32-45	thioredoxin TRX1	Saccharomyces cerevisiae S288C	57-62
24918063-9	2014	In particular, we proposed a pharmacophore model featuring two amino groups in the central part of the model and two lateral aromatic chains, which respectively establish electrostatic interactions with the acidic loop (Asp 108 and Glu 109) and a hydrogen bond with Ser 139, which is one of the key residues for Cdc34 activity.	Aspartic Acid	220-223	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	312-317
24884459-6	2014	YVAD is a tetrapeptide (tyrosine-valine-alanine-aspartic acid) that specifically inhibits caspase-1, which catalyzes the production of interleukin (IL)-1beta, an inflammatory cytokine, from its inactive precursor.	Aspartic Acid	48-61	caspase 1	Homo sapiens	90-99
24816812-6	2014	Moreover, VAChT-IR synapses on Renshaw cells contained, on average, aspartate immunolabeling at 2.5 to 2.8 times above the average neuropil level.	Aspartic Acid	68-77	solute carrier family 18 member A3	Homo sapiens	10-15
24768550-3	2014	ASPH encodes aspartyl/asparaginyl beta-hydroxylase (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growth factor (EGF)-domain-containing proteins.	Aspartic Acid	95-108	aspartate beta-hydroxylase	Homo sapiens	0-4
24802942-5	2014	Overall, significantly elevated cancer risk was found when all studies were pooled into the meta-analysis of XPG Asp1104His (dominant model: OR = 1.05, 95% CI = 1.00-1.10; Asp/His vs. Asp/Asp: OR = 1.06, 95% CI = 1.01-1.11).	Aspartic Acid	113-116	ERCC excision repair 5, endonuclease	Homo sapiens	109-112
24802942-5	2014	Overall, significantly elevated cancer risk was found when all studies were pooled into the meta-analysis of XPG Asp1104His (dominant model: OR = 1.05, 95% CI = 1.00-1.10; Asp/His vs. Asp/Asp: OR = 1.06, 95% CI = 1.01-1.11).	Aspartic Acid	172-175	ERCC excision repair 5, endonuclease	Homo sapiens	109-112
24802942-5	2014	Overall, significantly elevated cancer risk was found when all studies were pooled into the meta-analysis of XPG Asp1104His (dominant model: OR = 1.05, 95% CI = 1.00-1.10; Asp/His vs. Asp/Asp: OR = 1.06, 95% CI = 1.01-1.11).	Aspartic Acid	172-175	ERCC excision repair 5, endonuclease	Homo sapiens	109-112
24768550-3	2014	ASPH encodes aspartyl/asparaginyl beta-hydroxylase (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growth factor (EGF)-domain-containing proteins.	Aspartic Acid	95-108	aspartate beta-hydroxylase	Homo sapiens	13-50
24768550-3	2014	ASPH encodes aspartyl/asparaginyl beta-hydroxylase (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growth factor (EGF)-domain-containing proteins.	Aspartic Acid	95-108	aspartate beta-hydroxylase	Homo sapiens	52-56
24573245-5	2014	Among them, the benzyl ester of aspartic acid exhibited a k cat/K m value that was more than two orders of magnitude higher (1.75 x 10(5) M(-1) s(-1)) as compared to L-Arg (1.5 x 10(3) M(-1) s(-1)).	Aspartic Acid	32-45	Rho guanine nucleotide exchange factor 12	Homo sapiens	166-171
24615237-8	2014	To identify the ligand residues interacting with the negatively charged EXXXD motif of RXFP3, we replaced the three conserved arginines of relaxin-3 with negatively charged glutamate or aspartate, respectively.	Aspartic Acid	186-195	relaxin family peptide receptor 3	Homo sapiens	87-92
24673938-3	2014	Here, we show that L-Asp binds to full-length GluA2 with low affinity (Ki = 0.63 mM) and to the GluA2 LBD with even lower affinity (Ki = 2.6 mM), and we use differential scanning fluorimetry to show that L-Asp is able to stabilize the isolated GluA2 LBD.	Aspartic Acid	19-24	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	46-51
24616376-14	2014	Overall, the reaction by GAD is specific to Glu and can be applied to aid the electrodialysis separation of Asp and Glu.	Aspartic Acid	108-111	glutamate decarboxylase 1	Homo sapiens	25-28
24463019-3	2014	The SNP g2696: A&gt;G resulted in a change from asparagine to aspartic acid (p. N574D) in the leucine-rich repeat region in the carboxyl-terminal domain of IGFALS.	Aspartic Acid	62-75	insulin-like growth factor-binding protein complex acid labile subunit	Bos taurus	156-162
24673938-3	2014	Here, we show that L-Asp binds to full-length GluA2 with low affinity (Ki = 0.63 mM) and to the GluA2 LBD with even lower affinity (Ki = 2.6 mM), and we use differential scanning fluorimetry to show that L-Asp is able to stabilize the isolated GluA2 LBD.	Aspartic Acid	19-24	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	96-101
24673938-3	2014	Here, we show that L-Asp binds to full-length GluA2 with low affinity (Ki = 0.63 mM) and to the GluA2 LBD with even lower affinity (Ki = 2.6 mM), and we use differential scanning fluorimetry to show that L-Asp is able to stabilize the isolated GluA2 LBD.	Aspartic Acid	19-24	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	96-101
24673938-5	2014	Furthermore, we solved three structures of the GluA2 LBD in the presence of 7.5, 50 and 250 mM L-Asp.	Aspartic Acid	95-100	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	47-52
24673938-6	2014	Surprisingly, with 7.5 mM L-Asp, the GluA2 LBD crystallized as a mixed dimer, with L-Glu being present in one subunit, and neither L-Asp nor L-Glu being present in the other subunit.	Aspartic Acid	26-31	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	37-42
24673938-9	2014	The binding mode observed for L-Asp at the GluA2 LBD is very similar to that described for L-Glu.	Aspartic Acid	30-35	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	43-48
24673938-10	2014	Taking our findings together, we have shown that L-Asp can be used instead of L-Glu for ligand-dependent stabilization of the GluA2 LBD during purification.	Aspartic Acid	49-54	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	126-131
24736652-6	2014	LCAT presents a Ser/Asp/His catalytic triad with a peculiar geometry, which is shared with such other enzyme classes as lipases, proteases and esterases.	Aspartic Acid	20-23	lecithin-cholesterol acyltransferase	Homo sapiens	0-4
24509215-9	2014	Furthermore, canine VH CDR3 displays an overrepresentation of the neutral amino acid threonine and the negatively charged aspartic acid while proline content is similar to that in the human repertoire.	Aspartic Acid	122-135	cerebellar degeneration-related 3	Mus musculus	23-27
24568234-1	2014	We have previously reported that N-terminal alpha-ketoamide peptides can be formed through 4-oxo-2(E)-nonenal (ONE)-derived oxidative decarboxylation of aspartic acid (Asp), which converts angiotensin (Ang) II (DRVYIHPF) to pyruvamide-Ang II (Ang P, CH3COCONH-RVYIHPF).	Aspartic Acid	153-166	angiotensinogen	Homo sapiens	189-209
24568234-1	2014	We have previously reported that N-terminal alpha-ketoamide peptides can be formed through 4-oxo-2(E)-nonenal (ONE)-derived oxidative decarboxylation of aspartic acid (Asp), which converts angiotensin (Ang) II (DRVYIHPF) to pyruvamide-Ang II (Ang P, CH3COCONH-RVYIHPF).	Aspartic Acid	168-171	angiotensinogen	Homo sapiens	189-209
24568234-9	2014	The ONE- and hydroxyl radical-derived formation of N-terminal alpha-ketoamide and its transamination in the presence of PM were also observed in amyloid beta 1-11 (DAEFRHDSGYE), where the N-terminal Asp was converted to epimeric alanine.	Aspartic Acid	199-202	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-162
24758333-6	2014	Namely, the introduction of aspartic acid at position 185 (D185) conferred b12 susceptibility of 12 resistant AE-Env clones in the absence of N186 and/or N197, while the introduction of glycine at position 185 (G185) reduced the b12 susceptibility of 9 susceptible AE-Env clones in the absence of N186 and/or N197.	Aspartic Acid	28-41	endogenous retrovirus group K member 20	Homo sapiens	113-116
24758333-6	2014	Namely, the introduction of aspartic acid at position 185 (D185) conferred b12 susceptibility of 12 resistant AE-Env clones in the absence of N186 and/or N197, while the introduction of glycine at position 185 (G185) reduced the b12 susceptibility of 9 susceptible AE-Env clones in the absence of N186 and/or N197.	Aspartic Acid	28-41	endogenous retrovirus group K member 20	Homo sapiens	268-271
24656864-3	2014	We developed a statistical approach to identify and adjust for clinical heterogeneity within ACPA(-) RA and observed independent associations for serine and leucine at position 11 in HLA-DRbeta1 (p = 1.4 x 10(-13), odds ratio [OR] = 1.30) and for aspartate at position 9 in HLA-B (p = 2.7 x 10(-12), OR = 1.39) within the peptide binding grooves.	Aspartic Acid	247-256	major histocompatibility complex, class II, DR beta 1	Homo sapiens	183-186
24611845-4	2014	Structural analysis indicated that Grx8 possesses a negatively charged CXXC motif (Cys(33)-Pro(34)-Asp(35)-Cys(36)) and a GSH-recognition site, which are distinct from Grx1 and Grx2.	Aspartic Acid	99-102	glutathione-disulfide reductase GRX8	Saccharomyces cerevisiae S288C	35-39
24656864-4	2014	These amino acid positions induced associations at HLA-DRB1(*)03 (encoding serine at 11) and HLA-B(*)08 (encoding aspartate at 9).	Aspartic Acid	114-123	major histocompatibility complex, class II, DR beta 1	Homo sapiens	51-59
24656864-4	2014	These amino acid positions induced associations at HLA-DRB1(*)03 (encoding serine at 11) and HLA-B(*)08 (encoding aspartate at 9).	Aspartic Acid	114-123	major histocompatibility complex, class II, DR beta 1	Homo sapiens	51-54
24589657-3	2014	In human CPR, His(322) forms a hydrogen-bond with the highly conserved Asp(677), a member of the catalytic triad.	Aspartic Acid	71-74	cytochrome p450 oxidoreductase	Homo sapiens	9-12
24617810-3	2014	NMR spectroscopy and replica-exchange molecular dynamics indicate that introduction of a phosphate group or phosphomimetic at position 26 diminishes Abeta"s propensity to form a beta-hairpin, rigidifies the region around the modification site, and interferes with formation of a fibril-specific salt bridge between aspartic acid 23 and lysine 28.	Aspartic Acid	315-328	amyloid beta precursor protein	Homo sapiens	149-154
24298989-4	2014	TDP-43 expression increased glutamate levels, decreased the levels of other amino acids, including glutamine, aspartate, leucine and isoleucine, and impaired mitochondrial tricarboxylic acid cycle.	Aspartic Acid	110-119	TAR DNA binding protein	Rattus norvegicus	0-6
24363090-2	2014	Caspases activation is suggested to play a significant role in tau truncation at Aspartate 421 (D421) according to their ability to cleave recombinant tau in vitro.	Aspartic Acid	81-90	caspase 6	Homo sapiens	0-8
23927022-4	2014	RESULTS: Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086).	Aspartic Acid	51-54	glutathione S-transferase omega 2	Homo sapiens	45-50
23927022-7	2014	CONCLUSION: The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.	Aspartic Acid	51-54	glutathione S-transferase omega 2	Homo sapiens	45-50
24453179-1	2014	PLAP-1/asporin is an extracellular matrix protein that is predominantly expressed in the human periodontal ligament (PDL) and has an aspartic acid (D) repeat polymorphism in its N-terminal region.	Aspartic Acid	133-146	alkaline phosphatase, placental	Homo sapiens	0-6
24565675-10	2014	In addition, Asp increased the activities of tricarboxylic acid cycle key enzymes including citrate synthase, isocitrate dehydrogenase and alpha-oxoglutarate dehydrogenase complex.	Aspartic Acid	13-16	citrate synthase	Sus scrofa	92-108
23927022-4	2014	RESULTS: Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086).	Aspartic Acid	38-41	glutathione S-transferase omega 1	Homo sapiens	32-37
23927022-4	2014	RESULTS: Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086).	Aspartic Acid	51-54	glutathione S-transferase omega 2	Homo sapiens	45-50
23927022-4	2014	RESULTS: Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086).	Aspartic Acid	51-54	glutathione S-transferase omega 2	Homo sapiens	45-50
24679184-3	2014	SLC25A12 is a gene encoding a calcium-binding carrier protein that localizes to the mitochondria and is involved in the exchange of aspartate for glutamate in the inner membrane of the mitochondria regulating the cytosolic redox state.	Aspartic Acid	132-141	solute carrier family 25 member 12	Homo sapiens	0-8
24757296-0	2014	Synthesis of Gold Nanoparticles Coated with Aspartic Acid and Their Conjugation with FVIII Protein and FVIII Antibody.	Aspartic Acid	44-57	coagulation factor VIII	Homo sapiens	85-90
25011265-8	2014	The percentage of positive stained aging cells was dramatically increased, and could significantly up-regulate the expression of aging-related proteins P16 and RB, which were more obvious in the ASP + Ara-C group.	Aspartic Acid	195-198	cyclin dependent kinase inhibitor 2A	Homo sapiens	152-155
24559479-6	2014	The O-donor ligand in Pb7-MT2(II) was identified as the carboxyl groups of the aspartic acid residues at positions 2 and 56.	Aspartic Acid	79-92	metallothionein 2A	Homo sapiens	26-29
24380762-13	2014	We conclude that the presence of aspartate at residue 286 liberates NA from tetherin-dependent restriction upon exit from the ER compartment thus preventing restriction at the plasma membrane.	Aspartic Acid	33-42	bone marrow stromal cell antigen 2	Homo sapiens	76-84
24468324-4	2014	CsHMGB2 is 245 residues in length and contains two basic HMG boxes and an acidic C-terminal tail composed of 23 Asp/Glu residues.	Aspartic Acid	112-115	high mobility group protein B2	Cynoglossus semilaevis	0-7
24524365-15	2014	TEA, amantadine, quinidine, and verapamil significantly inhibited ASP(+) uptake into NCl-H441 cells, whereas the effect of d- and l-carnitine and ergothioneine, two OCTN substrates, was less pronounced.	Aspartic Acid	66-72	nucleolin	Homo sapiens	85-88
24480307-4	2014	The 5-LOX structure suggested association between Arg(101) in the beta-sandwich and Asp(166) in the catalytic domain, due to electrostatic interaction as well as hydrogen bonds.	Aspartic Acid	84-87	lysyl oxidase	Homo sapiens	6-9
24480307-8	2014	In the 5-LOX crystal structure, helix alpha2 and adjacent loops (including Asp(166)) of the 5-LOX catalytic domain has been proposed to form a flexible lid controlling access to the active site, and lid movement would be determined by bonding of lid residues to the C2-like beta-sandwich.	Aspartic Acid	75-78	lysyl oxidase	Homo sapiens	9-12
24480307-8	2014	In the 5-LOX crystal structure, helix alpha2 and adjacent loops (including Asp(166)) of the 5-LOX catalytic domain has been proposed to form a flexible lid controlling access to the active site, and lid movement would be determined by bonding of lid residues to the C2-like beta-sandwich.	Aspartic Acid	75-78	lysyl oxidase	Homo sapiens	94-97
24119159-5	2014	Substitutions with the phosphomimetic aspartate restored DNA-binding and transcriptional activity at serines 22 and 85, suggesting that they are potential sites of Gal4 phosphorylation in vivo.	Aspartic Acid	38-47	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	164-168
24407548-7	2014	Specifically, two domains, the Drosophila-specific Long Osk domain and the region that interacts with the germ plasm protein Lasp, are evolving at a faster rate than other regions of oskar.	Aspartic Acid	125-129	oskar	Drosophila melanogaster	183-188
24407548-9	2014	Our domain-based analysis suggests that changes in the Long Osk and Lasp-binding domains are strong candidates for the molecular basis of functional divergence between the Oskar proteins of D. melanogaster and D. virilis.	Aspartic Acid	68-72	oskar	Drosophila melanogaster	172-177
24623205-4	2014	However, we found that participants older than 67 years who carried a combination of eNOS (Asp/Asp) genotype and ADRB2 glycine (Gly) allele were at a higher risk of having hypertension (p=0.029).	Aspartic Acid	91-94	nitric oxide synthase 3	Homo sapiens	85-89
24436062-12	2014	Between biopsies, elevated serum aspartate and alanine aminotransferase (AST, ALT) (aOR AST: 3.34, ALT: 2.18 for &gt;25% values &gt;100 U/L versus &lt;25% values &gt;100 U/L) were strongly associated with fibrosis progression.	Aspartic Acid	33-42	solute carrier family 17 member 5	Homo sapiens	88-91
24129963-6	2014	OPN has an arginine-glycine-aspartic acid (RGD) motif, and protease cleavage reveals a SVVYGLR motif.	Aspartic Acid	28-41	secreted phosphoprotein 1	Homo sapiens	0-3
24623205-4	2014	However, we found that participants older than 67 years who carried a combination of eNOS (Asp/Asp) genotype and ADRB2 glycine (Gly) allele were at a higher risk of having hypertension (p=0.029).	Aspartic Acid	95-98	nitric oxide synthase 3	Homo sapiens	85-89
24659330-8	2014	However, in the presence of 14-3-3 proteins, the inhibition of SOS2 activity is decreased by the Ser-to-Ala mutation and enhanced by the Ser-to-Asp exchange.	Aspartic Acid	144-147	Protein kinase superfamily protein	Arabidopsis thaliana	63-67
24623205-5	2014	CONCLUSION: Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.	Aspartic Acid	145-148	adrenoceptor beta 2	Homo sapiens	189-194
24571195-4	2014	The enhanced in vitro reactivation efficacy determined for tertiary imidazole aldoximes compared to that of their quaternary N-methyl imidazolium analogues is attributed to ion pairing of the cationic imidazolium with Asp 70, altering a reactive alignment of the aldoxime with the phosphorus in the OP-hBChE conjugate.	Aspartic Acid	218-221	butyrylcholinesterase	Homo sapiens	302-307
24852854-4	2014	KRAS codon 12 Gly Asp, Gly, Val, and codon 13 Gly Cys gene mutations were tested using an in-house real-time ARMS PCR method.	Aspartic Acid	18-21	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
24586645-3	2014	This study aims to investigate the effect of a novel missense mutation on the aspartate/glutamate carrier (AGC) function of citrin protein, and to explore the aberrant transcript from c.615+5G&gt;A in the same CD infant.	Aspartic Acid	78-87	solute carrier family 25 member 13	Homo sapiens	124-130
24338473-2	2014	Here, we characterize a previously unexplored HAD family member (gene annotation, phosphoglycolate phosphatase), which we termed AUM, for aspartate-based, ubiquitous, Mg(2+)-dependent phosphatase.	Aspartic Acid	138-147	phosphoglycolate phosphatase	Homo sapiens	129-132
24586388-2	2014	An aspartatic acid (Asp) to asparagine (Asn) missense mutation at position 262 in the canine CNGB3 (D262N) subunit results in loss of cone function (daylight blindness), suggesting an important role for this aspartic acid residue in channel biogenesis and/or function.	Aspartic Acid	20-23	cyclic nucleotide gated channel subunit beta 3	Canis lupus familiaris	93-98
24586388-2	2014	An aspartatic acid (Asp) to asparagine (Asn) missense mutation at position 262 in the canine CNGB3 (D262N) subunit results in loss of cone function (daylight blindness), suggesting an important role for this aspartic acid residue in channel biogenesis and/or function.	Aspartic Acid	208-221	cyclic nucleotide gated channel subunit beta 3	Canis lupus familiaris	93-98
24586388-8	2014	Co-expressing CNGB3 Tri-Asp mutants with wild type CNGA3 results in some functional channels, however, their electrophysiological characterization matches the properties of homomeric CNGA3 channels.	Aspartic Acid	24-27	cyclic nucleotide gated channel subunit beta 3	Canis lupus familiaris	14-19
24586388-8	2014	Co-expressing CNGB3 Tri-Asp mutants with wild type CNGA3 results in some functional channels, however, their electrophysiological characterization matches the properties of homomeric CNGA3 channels.	Aspartic Acid	24-27	cyclic nucleotide-gated cation channel alpha-3	Canis lupus familiaris	51-56
24558497-5	2014	Consistent with these results, direct interaction of Sli15 with microtubules in vitro is greatly reduced either following phosphorylation by Ipl1 or when constitutive phosphorylation at the Ipl1-dependent phosphorylation sites is mimicked by aspartate or glutamate substitutions.	Aspartic Acid	242-251	Sli15p	Saccharomyces cerevisiae S288C	53-58
24558497-5	2014	Consistent with these results, direct interaction of Sli15 with microtubules in vitro is greatly reduced either following phosphorylation by Ipl1 or when constitutive phosphorylation at the Ipl1-dependent phosphorylation sites is mimicked by aspartate or glutamate substitutions.	Aspartic Acid	242-251	aurora kinase	Saccharomyces cerevisiae S288C	190-194
24321511-5	2014	Phospho-mimetic substitution of serines 15 and 18 with aspartate in the full-length VMAT2 resulted in reduced [(3)H]-5HT sequestration and reduced methamphetamine (METH)-stimulated efflux of preloaded [(3)H]-5HT.	Aspartic Acid	55-64	solute carrier family 18 member A2	Homo sapiens	84-89
24520163-6	2014	By contrast, in Rab5 the switch II aspartate is required for Rabex mediated GDP-release.	Aspartic Acid	35-44	RAB5A, member RAS oncogene family	Homo sapiens	16-20
24559985-5	2014	We produced a mutant FKBP12 molecule (FKBP12E31Q/D32N/W59F) where the residues Glu(31), Asp(32), and Trp(59) were converted to the corresponding residues in FKBP12.6.	Aspartic Acid	88-91	peptidyl-prolyl cis-trans isomerase FKBP1A	Oryctolagus cuniculus	21-27
24559985-5	2014	We produced a mutant FKBP12 molecule (FKBP12E31Q/D32N/W59F) where the residues Glu(31), Asp(32), and Trp(59) were converted to the corresponding residues in FKBP12.6.	Aspartic Acid	88-91	peptidyl-prolyl cis-trans isomerase FKBP1A	Oryctolagus cuniculus	38-44
24473359-3	2014	Enzyme replacement therapy using bone-targeting recombinant ALP, which has 10 aspartic acids in the C-terminal tail has developed.	Aspartic Acid	78-92	alkaline phosphatase, placental	Homo sapiens	60-63
24498414-6	2014	ERGIC-53 has a shallower sugar-binding pocket than VIP36 because of the single amino acid substitution, Asp-to-Gly.	Aspartic Acid	104-107	lectin, mannose binding 1	Homo sapiens	0-8
24498414-6	2014	ERGIC-53 has a shallower sugar-binding pocket than VIP36 because of the single amino acid substitution, Asp-to-Gly.	Aspartic Acid	104-107	lectin, mannose binding 2	Homo sapiens	51-56
24581800-7	2014	Based on these analyses, the residues His122 and Lys140 of beta1 and Glu 66, Asn 131, Asp 118, Glu 120, Glu133, Asn135, Ser 137 of beta3 were predicted to play a functional role.	Aspartic Acid	86-89	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	59-75
24581800-7	2014	Based on these analyses, the residues His122 and Lys140 of beta1 and Glu 66, Asn 131, Asp 118, Glu 120, Glu133, Asn135, Ser 137 of beta3 were predicted to play a functional role.	Aspartic Acid	86-89	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	131-136
23639078-2	2014	This allele is identical to DPB1*17:01 except for a single nucleotide substitution (GAC GAG) at position 57, which changes the encoded amino acid from Asp to Glu.	Aspartic Acid	151-154	major histocompatibility complex, class II, DP beta 1	Homo sapiens	28-32
24382305-11	2014	A structure of a G86D-DNA complex reveals a rearrangement in the beta4/5 loop comprising Leu84, the highly-conserved void-filling residue, thereby providing a structural rationale for the decreased glycosylase activity of the glycine to aspartate variant.	Aspartic Acid	237-246	tubulin beta 3 class III	Homo sapiens	65-72
24302611-6	2014	In contrast, the aspartic acid mutation disrupts binding with beta-dystroglycan despite an almost normal expression at the membrane, confirming a role for the ZZ domain in beta-dystroglycan binding but surprisingly demonstrating that such binding is not required for subsarcolemmal localization of dystrophin, even in the absence of actin binding domains.	Aspartic Acid	17-30	dystrophin	Homo sapiens	298-308
24363429-5	2014	The caspase-processing site was mapped to aspartate-135 in the central region of MyD88.	Aspartic Acid	42-51	MYD88 innate immune signal transduction adaptor	Homo sapiens	81-86
24397921-7	2014	Addition of C5a completely blocked ASP signaling and activity in both C5aRKO and WT adipocytes as well as 3T3-L1 adipocytes.	Aspartic Acid	35-38	hemolytic complement	Mus musculus	12-15
25165637-5	2014	The well-known fluorescent substrate for OCT transporters, 4-(4-(dimethylamino)-styryl)-N-methylpyridinium iodide (ASP+), previously shown to accumulate in glioma-cell cytoplasm in in vivo slices, began to accumulate in the nucleus of these cells, but not in cytoplasm, after 21 days post-implantation.	Aspartic Acid	115-119	plexin A2	Mus musculus	41-44
24510571-5	2014	HQ873871) has differed from HLA-B*33:03:01 by one nucleotide in exon 4, which resulted in nt 866 G  A substitution, which results in an amino acid substitution from Gly(GGT) to Asp(GAT) at codon 265.	Aspartic Acid	177-180	major histocompatibility complex, class I, B	Homo sapiens	28-33
24510571-5	2014	HQ873871) has differed from HLA-B*33:03:01 by one nucleotide in exon 4, which resulted in nt 866 G  A substitution, which results in an amino acid substitution from Gly(GGT) to Asp(GAT) at codon 265.	Aspartic Acid	177-180	glycine-N-acyltransferase	Homo sapiens	181-184
24573064-5	2014	One of the most studied eNOS gene polymorphisms is a c.894G&gt;T polymorphism that results in the conversion of Glu (GAG) to Asp (GAT) at position 298.	Aspartic Acid	125-128	nitric oxide synthase 3	Homo sapiens	24-28
24573064-5	2014	One of the most studied eNOS gene polymorphisms is a c.894G&gt;T polymorphism that results in the conversion of Glu (GAG) to Asp (GAT) at position 298.	Aspartic Acid	125-128	glycine-N-acyltransferase	Homo sapiens	130-133
24466299-2	2014	A previous study showed that the substitution of +20A&gt;G in PPARG changed the 7(th) amino acid from Asp to Gly, creating a mutant referred to as PPARG Asp7Gly.	Aspartic Acid	102-105	peroxisome proliferator activated receptor gamma	Bos taurus	62-67
24297171-9	2014	Of the MMPs tested, MMP-2 and MMP-9 most greatly favored the presence of charged residues with preference for the Gly-Asp-Lys series.	Aspartic Acid	118-121	matrix metallopeptidase 2	Homo sapiens	7-11
24297171-9	2014	Of the MMPs tested, MMP-2 and MMP-9 most greatly favored the presence of charged residues with preference for the Gly-Asp-Lys series.	Aspartic Acid	118-121	matrix metallopeptidase 2	Homo sapiens	20-25
24297171-9	2014	Of the MMPs tested, MMP-2 and MMP-9 most greatly favored the presence of charged residues with preference for the Gly-Asp-Lys series.	Aspartic Acid	118-121	matrix metallopeptidase 9	Homo sapiens	30-35
24297171-12	2014	More specifically, the lack of Gly-Asp-Lys clusters may diminish potential MMP-2 and MMP-9 collagenolytic activity.	Aspartic Acid	35-38	matrix metallopeptidase 2	Homo sapiens	75-80
24297171-12	2014	More specifically, the lack of Gly-Asp-Lys clusters may diminish potential MMP-2 and MMP-9 collagenolytic activity.	Aspartic Acid	35-38	matrix metallopeptidase 9	Homo sapiens	85-90
24466299-2	2014	A previous study showed that the substitution of +20A&gt;G in PPARG changed the 7(th) amino acid from Asp to Gly, creating a mutant referred to as PPARG Asp7Gly.	Aspartic Acid	102-105	peroxisome proliferator activated receptor gamma	Bos taurus	147-152
24076356-8	2014	When comparing the myoglobin sequence from TA with the Ovis aries myoglobin sequence, variations were observed at codons 21 (GGT GAT) and 78 (GAA AAG), and these variations lead to changes in the corresponding amino acids, i.e., Gly Asp and Glu Lys, respectively.	Aspartic Acid	233-236	myoglobin	Pantholops hodgsonii	19-28
24466094-3	2014	Previous studies examining heme-binding in two cytochrome b5 heme-binding domain-containing proteins, damage-associated protein 1 (Dap1; Saccharomyces cerevisiae) and human progesterone receptor membrane component 1 (PGRMC1), have revealed that conserved tyrosine (Y) 73, Y79, aspartic acid (D) 86, and Y127 residues present in human CYB5D2 may be involved in heme-binding.	Aspartic Acid	277-290	progesterone receptor membrane component 1	Homo sapiens	217-223
24275353-1	2014	We investigated on the neuronal nicotinic acetylcholine receptor subtypes involved in the cholinergic control of in vivo hippocampal glutamate (GLU), aspartate (ASP) and inhibitory gamma-aminobutyric acid (GABA) overflow.	Aspartic Acid	150-159	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	32-64
24275353-1	2014	We investigated on the neuronal nicotinic acetylcholine receptor subtypes involved in the cholinergic control of in vivo hippocampal glutamate (GLU), aspartate (ASP) and inhibitory gamma-aminobutyric acid (GABA) overflow.	Aspartic Acid	161-164	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	32-64
24428873-1	2014	BACKGROUND: Hemoglobin Shepherds Bush (Human Genome Variation Society name: HBB:c.224G &gt; A) is an unstable hemoglobin variant resulting from a beta 74 GGC to GAC mutation (Gly to Asp) that manifests clinically as hemolytic anemia or gall bladder disease due to chronic subclinical hemolysis.	Aspartic Acid	182-185	gamma-glutamylcyclotransferase	Homo sapiens	154-157
27896073-1	2014	BACKGROUND: Citrin, encoded by SLC25A13, is a component of the malate-aspartate shuttle, which is the main NADH-transporting system in the liver.	Aspartic Acid	70-79	solute carrier family 25 member 13	Homo sapiens	12-18
27896073-1	2014	BACKGROUND: Citrin, encoded by SLC25A13, is a component of the malate-aspartate shuttle, which is the main NADH-transporting system in the liver.	Aspartic Acid	70-79	solute carrier family 25 member 13	Homo sapiens	31-39
24275659-6	2014	This triggers cleavage of c-FLIPL at Asp-376 by caspase-8 to produce p43FLIP.	Aspartic Acid	37-40	caspase 8	Mus musculus	48-57
24466094-3	2014	Previous studies examining heme-binding in two cytochrome b5 heme-binding domain-containing proteins, damage-associated protein 1 (Dap1; Saccharomyces cerevisiae) and human progesterone receptor membrane component 1 (PGRMC1), have revealed that conserved tyrosine (Y) 73, Y79, aspartic acid (D) 86, and Y127 residues present in human CYB5D2 may be involved in heme-binding.	Aspartic Acid	277-290	progesterone receptor membrane component 1	Homo sapiens	173-215
24395786-7	2014	UCP2 reconstituted in lipid vesicles catalyzed the exchange of malate, oxaloacetate, and aspartate for phosphate plus a proton from opposite sides of the membrane.	Aspartic Acid	89-98	uncoupling protein 2	Homo sapiens	0-4
24147638-0	2014	SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct.	Aspartic Acid	44-53	solute carrier family 22 member 13	Homo sapiens	0-8
24147638-6	2014	LC-MS difference shading showed that heterologous expression of human and rat SLC22A13 in HEK (human embryonic kidney)-293 cells stimulates efflux of guanidinosuccinate, aspartate, glutamate and taurine.	Aspartic Acid	170-179	solute carrier family 22 member 13	Rattus norvegicus	78-86
24147638-11	2014	Expression of SLC22A13 strongly stimulated efflux of aspartate, taurine and glutamate.	Aspartic Acid	53-62	solute carrier family 22 member 13	Homo sapiens	14-22
24147638-13	2014	We propose that in type A intercalated cells, SLC22A13 compensates luminal exit of protons by mediating the basolateral expulsion of the anions aspartate and glutamate.	Aspartic Acid	144-153	solute carrier family 22 member 13	Homo sapiens	46-54
24446315-6	2014	Individuals with XPD 711 Asp and XPD 312 Asn alleles responded poorly to chemotherapy when compared with the wide-type genotype.	Aspartic Acid	25-28	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	17-20
24446315-9	2014	On the other hand, the XPD 711 Asp allele was associated with poorer progression free survival and overall survival compared to the C/C genotype, with HRs of 1.89 and 1.90.	Aspartic Acid	31-34	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	23-26
24076356-8	2014	When comparing the myoglobin sequence from TA with the Ovis aries myoglobin sequence, variations were observed at codons 21 (GGT GAT) and 78 (GAA AAG), and these variations lead to changes in the corresponding amino acids, i.e., Gly Asp and Glu Lys, respectively.	Aspartic Acid	233-236	myoglobin	Ovis aries	66-75
24283798-7	2014	These N-Abeta1-5 fragments with l-aspartic acid (l-Asp), d-Asp, l-isoAsp, and d-isoAsp could be separated using the UPLC system with a conventional reversed-phase column and mobile phase.	Aspartic Acid	32-47	N-alpha-acetyltransferase 15, NatA auxiliary subunit	Homo sapiens	6-16
24283798-7	2014	These N-Abeta1-5 fragments with l-aspartic acid (l-Asp), d-Asp, l-isoAsp, and d-isoAsp could be separated using the UPLC system with a conventional reversed-phase column and mobile phase.	Aspartic Acid	49-54	N-alpha-acetyltransferase 15, NatA auxiliary subunit	Homo sapiens	6-16
24283798-9	2014	The CCD-UPLC-MS/MS assay of potential N-Abeta1-5 allowed for the discovery of the present and ratio levels of these N-Abeta1-5 sequences with l-Asp, d-Asp, l-isoAsp, and d-isoAsp.	Aspartic Acid	142-147	N-alpha-acetyltransferase 15, NatA auxiliary subunit	Homo sapiens	38-48
24283798-9	2014	The CCD-UPLC-MS/MS assay of potential N-Abeta1-5 allowed for the discovery of the present and ratio levels of these N-Abeta1-5 sequences with l-Asp, d-Asp, l-isoAsp, and d-isoAsp.	Aspartic Acid	142-147	N-alpha-acetyltransferase 15, NatA auxiliary subunit	Homo sapiens	116-126
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	88-101	CREB binding protein	Mus musculus	0-20
24366945-5	2014	In addition to E2 dimerization, we show that a highly conserved arginine residue in the donor Ube2g2 senses the presence of an aspartate in the acceptor ubiquitin to position only Lys48 of ubiquitin in proximity to the donor E2 active site.	Aspartic Acid	127-136	ubiquitin conjugating enzyme E2 G2	Homo sapiens	94-100
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	88-101	CREB binding protein	Mus musculus	22-25
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	88-101	E1A binding protein p300	Mus musculus	27-31
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	88-101	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	116-122
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	103-106	CREB binding protein	Mus musculus	0-20
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	103-106	CREB binding protein	Mus musculus	22-25
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	103-106	E1A binding protein p300	Mus musculus	27-31
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	103-106	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	116-122
24140612-6	2014	While osteoclast activation occurred when pASP was used as the process-directing agent, using OPN resulted in a dramatic effect on osteoclast activation, presumably because of the inherent arginine-glycine-aspartate acid ligands of OPN.	Aspartic Acid	206-215	secreted phosphoprotein 1	Mus musculus	94-97
25345508-10	2014	In the case of "levomilnacipran-BACE1" interaction, levomilnacipran interacted with two very crucial aspartic acid residues of BACE-1, namely, D32 and D228.	Aspartic Acid	101-114	beta-secretase 1	Homo sapiens	32-37
24803226-5	2014	In addition to Abeta peptides starting with an Asp at position 1, a variety of different N-truncated Abeta peptides have been identified starting with amino residue Ala-2, pyroglutamylated Glu-3, Phe-4, Arg-5, His-6, Asp-7, Ser-8, Gly-9, Tyr-10 and pyroglutamylated Glu-11.	Aspartic Acid	217-220	amyloid beta precursor protein	Homo sapiens	101-106
25051764-1	2014	While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level.	Aspartic Acid	57-60	caspase 3	Rattus norvegicus	73-82
24377566-3	2014	We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), effectively inhibited human AML CD34+CD38?	Aspartic Acid	52-55	CD34 molecule	Homo sapiens	157-161
24377566-3	2014	We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), effectively inhibited human AML CD34+CD38?	Aspartic Acid	52-55	CD38 molecule	Homo sapiens	162-166
24377566-7	2014	Colony formation assays further showed that ASP significantly suppressed the formation of colonies derived from AML CD34+CD38?	Aspartic Acid	44-47	CD34 molecule	Homo sapiens	116-120
24377566-7	2014	Colony formation assays further showed that ASP significantly suppressed the formation of colonies derived from AML CD34+CD38?	Aspartic Acid	44-47	CD38 molecule	Homo sapiens	121-125
24377566-10	2014	Examination of the underlying mechanisms revealed that ASP induced CD34+CD38?	Aspartic Acid	55-58	CD34 molecule	Homo sapiens	67-71
24377566-10	2014	Examination of the underlying mechanisms revealed that ASP induced CD34+CD38?	Aspartic Acid	55-58	CD38 molecule	Homo sapiens	72-76
25036958-5	2014	Additionally, point mutagenesis analysis showed that the substitution of Asp by Gly within the Pro-Val-Asp-Leu-Thr (PVDLT) motif of gKLF3 significantly reduced the ability of gKLF3 to regulate the promoter activities of FABP4, FASN, LPL, C/EBPalpha, and PPARgamma.	Aspartic Acid	73-76	fatty acid binding protein 4	Gallus gallus	220-225
25036958-5	2014	Additionally, point mutagenesis analysis showed that the substitution of Asp by Gly within the Pro-Val-Asp-Leu-Thr (PVDLT) motif of gKLF3 significantly reduced the ability of gKLF3 to regulate the promoter activities of FABP4, FASN, LPL, C/EBPalpha, and PPARgamma.	Aspartic Acid	73-76	fatty acid synthase	Gallus gallus	227-231
25036958-5	2014	Additionally, point mutagenesis analysis showed that the substitution of Asp by Gly within the Pro-Val-Asp-Leu-Thr (PVDLT) motif of gKLF3 significantly reduced the ability of gKLF3 to regulate the promoter activities of FABP4, FASN, LPL, C/EBPalpha, and PPARgamma.	Aspartic Acid	73-76	lipoprotein lipase	Gallus gallus	233-236
25036958-5	2014	Additionally, point mutagenesis analysis showed that the substitution of Asp by Gly within the Pro-Val-Asp-Leu-Thr (PVDLT) motif of gKLF3 significantly reduced the ability of gKLF3 to regulate the promoter activities of FABP4, FASN, LPL, C/EBPalpha, and PPARgamma.	Aspartic Acid	73-76	CCAAT/enhancer binding protein alpha	Gallus gallus	238-248
25036958-5	2014	Additionally, point mutagenesis analysis showed that the substitution of Asp by Gly within the Pro-Val-Asp-Leu-Thr (PVDLT) motif of gKLF3 significantly reduced the ability of gKLF3 to regulate the promoter activities of FABP4, FASN, LPL, C/EBPalpha, and PPARgamma.	Aspartic Acid	73-76	peroxisome proliferator-activated receptor gamma	Gallus gallus	254-263
24129262-5	2014	Presymptomatic SOD1(G93A) mice have significant differences in concentrations of several plasma metabolites compared to wild type animals, most notably in the concentrations of aspartate, cystine/cysteine, and phosphoethanolamine, and in changes indicative of methylation defects.	Aspartic Acid	177-186	superoxide dismutase 1, soluble	Mus musculus	15-19
25329837-7	2014	The selected molecules have been subjected to docking study against Presenilin1 C-terminal fragment that houses Asp 385 in place of presenilin, as its structure is unavailable.	Aspartic Acid	112-115	presenilin 1	Homo sapiens	68-79
25345508-10	2014	In the case of "levomilnacipran-BACE1" interaction, levomilnacipran interacted with two very crucial aspartic acid residues of BACE-1, namely, D32 and D228.	Aspartic Acid	101-114	beta-secretase 1	Homo sapiens	127-133
24268404-4	2014	These proteases cleave OPN at several positions near the integrin-binding sequence Arg-Gly-Asp(138).	Aspartic Acid	91-94	secreted phosphoprotein 1	Bos taurus	23-26
24138715-9	2014	Keeping in mind that the glycine present at position 12 can be substituted by valine, aspartic acid or cysteine, it could be well understood that each different substitution plays a different role in K-RAS-dependent processes.	Aspartic Acid	86-99	KRAS proto-oncogene, GTPase	Homo sapiens	200-205
23726040-6	2014	RESULTS: Compared with the C57BL/6 allele, the BALB/c CD11a allele contained a nonsynonymous change from asparagine to aspartic acid within the metal ion binding domain.	Aspartic Acid	119-132	integrin subunit alpha L	Homo sapiens	54-59
24432778-5	2014	We report isolated Hb Memphis trait in Turkish individuals in whom the initial laboratory incorrectly identified the alpha variant as Q-Thailand [alpha74(EF3)Asp His; HBA1: c.223G &gt; C].	Aspartic Acid	158-161	hemoglobin subunit alpha 1	Homo sapiens	167-171
24404772-2	2014	The DRY motif (Asp, Arg, Tyr) of the intracellular loop 2 (ICL2), which is highly conserved in the GPCRs has been shown to be essential for the stability of folding of CCR5 and the interaction with beta-arrestin.	Aspartic Acid	15-18	C-C motif chemokine receptor 5	Homo sapiens	168-172
26819895-2	2014	Backbone cleavages at the N-Calpha bonds of Xxx-Asp, Xxx-Asn, Xxx-Cys, and Gly-Xxx residues gave discontinuous intense peaks of c-ions, independent of positive and negative ion mode.	Aspartic Acid	48-51	CEA cell adhesion molecule 6	Homo sapiens	26-34
24515575-7	2014	SLC25A12 encodes the neuronal aspartate-glutamate carrier 1 (AGC1) protein, an essential component of the neuronal malate/aspartate shuttle that transfers NADH and H(+) reducing equivalents from the cytosol to mitochondria.	Aspartic Acid	30-39	solute carrier family 25 member 12	Homo sapiens	0-8
24515575-7	2014	SLC25A12 encodes the neuronal aspartate-glutamate carrier 1 (AGC1) protein, an essential component of the neuronal malate/aspartate shuttle that transfers NADH and H(+) reducing equivalents from the cytosol to mitochondria.	Aspartic Acid	30-39	solute carrier family 25 member 12	Homo sapiens	61-65
24515575-8	2014	AGC1 activity enables neuronal export of aspartate, the glial substrate necessary for proper neuronal myelination.	Aspartic Acid	41-50	solute carrier family 25 member 12	Homo sapiens	0-4
24239724-4	2014	The percent DMA of individuals with the Ala/Asp genotype of glutathione S-transferase omega 1 (GSTO1) was significantly lower than those with Ala/Ala.	Aspartic Acid	44-47	glutathione S-transferase omega 1	Homo sapiens	60-93
25177232-5	2014	Interestingly, intracellular asparagine was also depleted rapidly, and the mechanism was suggested to involve rapid export of intracellular asparagine followed by rapid conversion to aspartic acid by L-ASP.	Aspartic Acid	183-196	asparaginase and isoaspartyl peptidase 1	Homo sapiens	200-205
24239724-4	2014	The percent DMA of individuals with the Ala/Asp genotype of glutathione S-transferase omega 1 (GSTO1) was significantly lower than those with Ala/Ala.	Aspartic Acid	44-47	glutathione S-transferase omega 1	Homo sapiens	95-100
24379646-4	2013	Direct sequencing revealed a heterozygous G&gt;A transversion at c.1042 of the coding sequence in exon 7 of BFSP1 (c.1042G&gt;A) in all affected members, which resulted in the substitution of a wild-type aspartate to an asparagine (D348N).	Aspartic Acid	204-213	beaded filament structural protein 1	Homo sapiens	108-113
24791469-4	2014	Seven out of 10 residues composing this site (Gln-133, Asn-249, Val-250, Asp-251, Val-252, Asn-253 and Glu-254) are obligatory components of the dinitroanilines" binding site on the plant alpha-tubulin surface.	Aspartic Acid	73-76	tubulin alpha-5	Arabidopsis thaliana	188-201
24217250-8	2013	Langerin with Asp-288 and Ile-313 shows no binding to 6SO4-Gal-terminated glycans and increased binding to GlcNAc-terminated structures, but overall decreased binding to glycans.	Aspartic Acid	14-17	CD207 molecule	Homo sapiens	0-8
24379646-6	2013	CONCLUSIONS: A novel mutation (c.1042G&gt;A) at exon 7 of BFSP1, which creates a substitution of an aspartate to an asparagine (p.D348N) was identified to be associated with autosomal dominant congenital cataract in a Chinese family.	Aspartic Acid	100-109	beaded filament structural protein 1	Homo sapiens	58-63
24266801-0	2013	Total synthesis of human galanin-like peptide through an aspartic acid ligation.	Aspartic Acid	57-70	galanin like peptide	Homo sapiens	25-45
24255108-3	2013	The mutation substituting the aspartic acid at position 838 (equivalent to the human aspartic acid residue at position 835) with a tyrosine (referred to as FLT3/D835Y hereafter) is the most frequent kinase domain mutation, converting aspartic acid to tyrosine.	Aspartic Acid	30-43	fms related receptor tyrosine kinase 3	Homo sapiens	156-160
24255108-3	2013	The mutation substituting the aspartic acid at position 838 (equivalent to the human aspartic acid residue at position 835) with a tyrosine (referred to as FLT3/D835Y hereafter) is the most frequent kinase domain mutation, converting aspartic acid to tyrosine.	Aspartic Acid	85-98	fms related receptor tyrosine kinase 3	Homo sapiens	156-160
24255108-3	2013	The mutation substituting the aspartic acid at position 838 (equivalent to the human aspartic acid residue at position 835) with a tyrosine (referred to as FLT3/D835Y hereafter) is the most frequent kinase domain mutation, converting aspartic acid to tyrosine.	Aspartic Acid	85-98	fms related receptor tyrosine kinase 3	Homo sapiens	156-160
24328126-8	2013	Only the Asp/Glu-Dap interactions with shorter side chains and the Aad-Orn/Lys interactions with longer side chains exhibited stabilizing energetics, mostly relying on electrostatics and hydrophobics, respectively.	Aspartic Acid	9-12	death associated protein	Homo sapiens	17-20
24266801-2	2013	Here, we demonstrate that the aspartic acid ligation can be employed to achieve an efficient synthesis of hGALP.	Aspartic Acid	30-43	galanin like peptide	Homo sapiens	106-111
24337294-6	2013	This homogeneous erythropoietin glycosylated at the three wild-type aspartates with N-linked high-mannose sialic acid-containing oligosaccharides and O-linked glycophorin exhibits Procrit-level in vivo activity in mice.	Aspartic Acid	68-78	erythropoietin	Mus musculus	17-31
24028142-3	2013	Brain Iowa deposits consist primarily of a mixture of mutated and non-mutated Abeta species exhibiting partial aspartate isomerization at positions 1, 7 and 23.	Aspartic Acid	111-120	amyloid beta precursor protein	Homo sapiens	78-83
24155240-1	2013	NAT8L (N-acetyltransferase 8-like) catalyzes the formation of N-acetylaspartate (NAA) from acetyl-CoA and aspartate.	Aspartic Acid	70-79	N-acetyltransferase 8-like	Mus musculus	0-5
24155240-1	2013	NAT8L (N-acetyltransferase 8-like) catalyzes the formation of N-acetylaspartate (NAA) from acetyl-CoA and aspartate.	Aspartic Acid	70-79	N-acetyltransferase 8-like	Mus musculus	7-33
24154564-3	2013	Indeed, it is well established that alphavbeta3 integrin plays a key role in tumor angiogenesis acting like a receptor for the extracellular matrix proteins like vitronectin, fibronectin through the arginine-glycine-aspartic acid (RGD) sequence.	Aspartic Acid	216-229	vitronectin	Homo sapiens	162-173
24349509-4	2013	It exhibited an evolutionarily conserved structure of mammalian caspase-3 genes, including a pro-domain, a large subunit, a small subunit and other motifs such as the pentapeptide active-site motif (QACRG) and the putative cleavage sites at the aspartic acids.	Aspartic Acid	245-259	caspase 3	Homo sapiens	64-73
24154564-3	2013	Indeed, it is well established that alphavbeta3 integrin plays a key role in tumor angiogenesis acting like a receptor for the extracellular matrix proteins like vitronectin, fibronectin through the arginine-glycine-aspartic acid (RGD) sequence.	Aspartic Acid	216-229	fibronectin 1	Homo sapiens	175-186
24099007-2	2013	Upon assembly with its three protein cofactors (nicastrin, Aph-1 and Pen-2), presenilin undergoes autoproteolysis into two subunits, each of which contributes one of the catalytic aspartates to the active site.	Aspartic Acid	180-190	nicastrin	Homo sapiens	48-57
24163367-8	2013	Cell surface delivery of a Nt-THIK2-CD161 chimera is increased by mutating the arginines of the retention motif but also by converting the serine embedded in this motif to aspartate, suggesting a phosphorylation-dependent regulation of THIK2 trafficking.	Aspartic Acid	172-181	potassium two pore domain channel subfamily K member 12	Homo sapiens	30-35
24312623-7	2013	We confirm the critical role of Cys239 residue for SEMG1 binding to EPPIN and inhibition of sperm motility by showing that recombinant SEMG1 mutants in which Cys239 residue was changed to glycine, aspartic acid, histidine, serine or arginine have reduced capacity to interact to EPPIN and to inhibit human sperm motility in vitro.	Aspartic Acid	197-210	semenogelin 1	Homo sapiens	135-140
24015671-7	2013	This was supported by mutagenesis and functional analyses, which identified two key residues (Asp(488) and Trp(621)) in the TRIM25 B30.2 domain as being critical for binding to the RIG-I CARDs.	Aspartic Acid	94-97	tripartite motif containing 25	Homo sapiens	124-130
24015671-7	2013	This was supported by mutagenesis and functional analyses, which identified two key residues (Asp(488) and Trp(621)) in the TRIM25 B30.2 domain as being critical for binding to the RIG-I CARDs.	Aspartic Acid	94-97	DExD/H-box helicase 58	Homo sapiens	181-186
24099007-2	2013	Upon assembly with its three protein cofactors (nicastrin, Aph-1 and Pen-2), presenilin undergoes autoproteolysis into two subunits, each of which contributes one of the catalytic aspartates to the active site.	Aspartic Acid	180-190	presenilin enhancer, gamma-secretase subunit	Homo sapiens	69-74
24206140-2	2013	In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin alphavbeta3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) imaging of integrin alphavbeta3 expression.	Aspartic Acid	54-57	integrin subunit alpha V	Homo sapiens	83-103
23978401-3	2013	In this study, we tested whether GFP- or GST-tagged HuR constructs bearing a phosphomimetic Ser (S)-to-Asp (D) substitution at the different PKC target sites, would affect different HuR functions including HuR nucleo-cytoplasmic redistribution and binding to different types of ARE-containing mRNAs.	Aspartic Acid	103-106	ELAV like RNA binding protein 1	Homo sapiens	52-55
23556418-5	2013	We found that DHDPS2 plays a crucial role in controlling lysine biosynthesis, thereby stabilizing flux through the whole aspartate pathway.	Aspartic Acid	121-130	dihydrodipicolinate synthase	Arabidopsis thaliana	14-20
23279838-0	2013	Clinical and molecular characterization of hemoglobin Maputo [beta 47 (CD6) Asp &gt; Tyr HBB: c.142G &gt; T] and G-Ferrara [beta 57 (E1) Asn &gt; Lys HBB: c.174C &gt; A] in a newborn screening in Brazil.	Aspartic Acid	76-79	CD6 molecule	Homo sapiens	71-74
24226268-5	2013	On the other hand, despite in vitro evidence that caspase-3 cleaves monomeric tau at Asp(421), to date, this truncation has not been demonstrated to be executed by this protease in polymeric tau entities.	Aspartic Acid	85-88	caspase 3	Homo sapiens	50-59
24226268-5	2013	On the other hand, despite in vitro evidence that caspase-3 cleaves monomeric tau at Asp(421), to date, this truncation has not been demonstrated to be executed by this protease in polymeric tau entities.	Aspartic Acid	85-88	microtubule associated protein tau	Homo sapiens	78-81
24290447-11	2013	TGF-beta1 significantly decreased the concentrations of 2 excitatory amino acids, aspartate and glutamate, in the spinal dialysates in CCI rats.	Aspartic Acid	82-91	transforming growth factor, beta 1	Rattus norvegicus	0-9
23812163-5	2013	Concentration-dependent inhibition of ASP(+) uptake by TPA, cimetidine, quinidine, and metformin confirmed functional endogenous organic cation transporter 2 (OCT2) expression in ciPTEC.	Aspartic Acid	38-44	solute carrier family 22 member 2	Homo sapiens	129-157
23812163-5	2013	Concentration-dependent inhibition of ASP(+) uptake by TPA, cimetidine, quinidine, and metformin confirmed functional endogenous organic cation transporter 2 (OCT2) expression in ciPTEC.	Aspartic Acid	38-44	solute carrier family 22 member 2	Homo sapiens	159-163
24226268-2	2013	Here, we report immunohistochemical staining of the Tau-C3 antibody, which recognizes Asp(421)-truncated tau, in a group of AD cases with different extents of cognitive impairment.	Aspartic Acid	86-89	microtubule associated protein tau	Homo sapiens	52-55
24226268-2	2013	Here, we report immunohistochemical staining of the Tau-C3 antibody, which recognizes Asp(421)-truncated tau, in a group of AD cases with different extents of cognitive impairment.	Aspartic Acid	86-89	microtubule associated protein tau	Homo sapiens	105-108
24226268-3	2013	In the hippocampus, we found distinct nonfibrillary aggregates of Asp(421)-truncated tau.	Aspartic Acid	66-69	microtubule associated protein tau	Homo sapiens	85-88
23849768-4	2013	Among the tested patients, 76.09% of patients had wt-KRAS genotype and 23.91% were KRAS mutants and the majority of mutations would result in an amino acid substitution of glycine by aspartic acid (68.2%) The predominant mutations are G&gt;A transitions and G&gt;T transversions.	Aspartic Acid	183-196	KRAS proto-oncogene, GTPase	Homo sapiens	83-87
24375045-0	2013	The role of the 148 Asp/Glu polymorphism of the APE1 gene in the development and progression of primary open angle glaucoma development in the Polish population.	Aspartic Acid	20-23	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	48-52
24121505-4	2013	PMA-induced shedding of Tim-3 was abrogated by deletion of amino acids Glu(181)-Asp(190) of the stalk region and Tim-3 lacking the intracellular domain was not efficiently cleaved after PMA stimulation.	Aspartic Acid	80-83	hepatitis A virus cellular receptor 2	Homo sapiens	24-29
24064216-2	2013	Computational models of human P-gp in the apo- and nucleotide-bound conformation show that the adenine group of ATP forms hydrogen bonds with the conserved Asp-164 and Asp-805 in intracellular loops 1 and 3, respectively, which are located at the interface between the nucleotide binding domains and transmembrane domains.	Aspartic Acid	168-171	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
24303080-10	2013	Mutation of this threonine to aspartic acid, to mimic phosphorylation, disrupts the binding of the coiled-coil domain to c-terminal regions and promotes membrane association of cytohesin 2.	Aspartic Acid	30-43	cytohesin 2	Homo sapiens	177-188
24204043-1	2013	PURPOSE: Substitutions of aspartate-47 (D47) of Connexin50 (Cx50) have been linked to autosomal dominant congenital cataracts in several human pedigrees.	Aspartic Acid	26-35	gap junction protein alpha 8	Homo sapiens	48-58
24204043-1	2013	PURPOSE: Substitutions of aspartate-47 (D47) of Connexin50 (Cx50) have been linked to autosomal dominant congenital cataracts in several human pedigrees.	Aspartic Acid	26-35	gap junction protein alpha 8	Homo sapiens	60-64
24383085-0	2013	Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-beta.	Aspartic Acid	14-27	amyloid beta precursor protein	Homo sapiens	87-99
24244460-5	2013	Here, we show that inducible overexpression of ARR22 in Arabidopsis enhanced dehydration, drought, and cold tolerance in a dexamethasone-dependent manner, whereas mutation of the putative phospho-accepting Asp to Asn in ARR22 (ARR22(D74N)) abolished these tolerance phenotypes.	Aspartic Acid	206-209	response regulator 22	Arabidopsis thaliana	47-52
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Aspartic Acid	26-29	cyclin dependent kinase 5	Homo sapiens	108-112
24278104-5	2013	Further, when expressed in multiple tumor cell lines, single point mutation of Aspartate(346) (D(346)) to Glutamate (E(346)), maspin(D346E), was predominantly nuclear, whereas wild type maspin (maspin(WT)) was both cytoplasmic and nuclear.	Aspartic Acid	79-88	serpin family B member 5	Homo sapiens	126-131
24278104-5	2013	Further, when expressed in multiple tumor cell lines, single point mutation of Aspartate(346) (D(346)) to Glutamate (E(346)), maspin(D346E), was predominantly nuclear, whereas wild type maspin (maspin(WT)) was both cytoplasmic and nuclear.	Aspartic Acid	79-88	serpin family B member 5	Homo sapiens	126-132
24278104-5	2013	Further, when expressed in multiple tumor cell lines, single point mutation of Aspartate(346) (D(346)) to Glutamate (E(346)), maspin(D346E), was predominantly nuclear, whereas wild type maspin (maspin(WT)) was both cytoplasmic and nuclear.	Aspartic Acid	79-88	serpin family B member 5	Homo sapiens	186-192
24064216-2	2013	Computational models of human P-gp in the apo- and nucleotide-bound conformation show that the adenine group of ATP forms hydrogen bonds with the conserved Asp-164 and Asp-805 in intracellular loops 1 and 3, respectively, which are located at the interface between the nucleotide binding domains and transmembrane domains.	Aspartic Acid	156-159	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Aspartic Acid	26-29	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	150-153
23687069-3	2013	An ELP matrix TGPG[VGRGD(VGVPG)6]20WPC (referred to as REP) contains multiple Arg-Gly-Asp motifs.	Aspartic Acid	86-89	nuclear receptor subfamily 5 group A member 1	Homo sapiens	3-6
24255708-2	2013	The human HMGB1 is composed of two binding motifs, known as Boxes A and B, are L-shaped alpha-helix structures, followed by a random-coil acidic tail that consists of 30 Asp and Glu residues.	Aspartic Acid	170-173	high mobility group box 1	Homo sapiens	10-15
23837815-8	2013	L-aspartate synthesis was exclusively through mitochondrial metabolism of L-serine to pyruvate and ammonia, involving Cha1p, cytoplasmic pyruvate carboxylases Pyc1p and Pyc2p, and the cytoplasmic aspartate aminotransferase Aat2p.	Aspartic Acid	0-11	L-serine/L-threonine ammonia-lyase CHA1	Saccharomyces cerevisiae S288C	118-123
23837815-8	2013	L-aspartate synthesis was exclusively through mitochondrial metabolism of L-serine to pyruvate and ammonia, involving Cha1p, cytoplasmic pyruvate carboxylases Pyc1p and Pyc2p, and the cytoplasmic aspartate aminotransferase Aat2p.	Aspartic Acid	0-11	pyruvate carboxylase 1	Saccharomyces cerevisiae S288C	159-164
23837815-8	2013	L-aspartate synthesis was exclusively through mitochondrial metabolism of L-serine to pyruvate and ammonia, involving Cha1p, cytoplasmic pyruvate carboxylases Pyc1p and Pyc2p, and the cytoplasmic aspartate aminotransferase Aat2p.	Aspartic Acid	0-11	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	169-174
23837815-8	2013	L-aspartate synthesis was exclusively through mitochondrial metabolism of L-serine to pyruvate and ammonia, involving Cha1p, cytoplasmic pyruvate carboxylases Pyc1p and Pyc2p, and the cytoplasmic aspartate aminotransferase Aat2p.	Aspartic Acid	0-11	aspartate transaminase AAT2	Saccharomyces cerevisiae S288C	223-228
24092756-6	2013	We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32), Leu-341(6.33), and Thr-344(6.36), as potential key contacts with the extreme C-terminal helix alpha5 of Galphai.	Aspartic Acid	172-175	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	99-102
24092756-6	2013	We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32), Leu-341(6.33), and Thr-344(6.36), as potential key contacts with the extreme C-terminal helix alpha5 of Galphai.	Aspartic Acid	172-175	cannabinoid receptor 1	Homo sapiens	119-122
24092756-6	2013	We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32), Leu-341(6.33), and Thr-344(6.36), as potential key contacts with the extreme C-terminal helix alpha5 of Galphai.	Aspartic Acid	172-175	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	166-169
24142104-6	2013	Asp interacts with myosin II regulating its polarized distribution along the apico-basal axis.	Aspartic Acid	0-3	zipper	Drosophila melanogaster	19-28
24142104-8	2013	We propose that Asp regulates neuroepithelium morphogenesis through myosin-II-mediated structural and mechanical processes to maintain force balance and tissue cohesiveness.	Aspartic Acid	16-19	zipper	Drosophila melanogaster	68-77
24044898-4	2013	PIMT is a repair enzyme that initiates the conversion of l-isoAsp (or d-Asp) residues to l-Asp residues.	Aspartic Acid	89-94	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	0-4
23942062-0	2013	Association between aspartic acid repeat polymorphism of the asporin gene and susceptibility to knee osteoarthritis: a genetic meta-analysis.	Aspartic Acid	20-33	asporin	Homo sapiens	61-68
23942062-3	2013	Recently, several genetic studies have suggested that susceptibility to KOA is affected by the number of aspartic acid (D) residues in the amino-terminal of the asporin protein, but evidence remains conflicting.	Aspartic Acid	105-118	asporin	Homo sapiens	161-168
24244196-5	2013	The WD (tryptophan-aspartate) repeat domain 5 (WDR5) and host cell factor 1 (HCF1) are shared among members of the MLL/SET (mixed-lineage leukemia/set-domain containing) family of histone H3K4 methyltransferase complexes.	Aspartic Acid	19-28	WD repeat domain 5	Homo sapiens	47-51
24066782-1	2013	The reactivity of asparagine residues in Cu, Zn superoxide dismutase (SOD1) to deamidate to aspartate remains uncharacterized; its occurrence in SOD1 has not been investigated, and the biophysical effects of deamidation on SOD1 are unknown.	Aspartic Acid	92-101	superoxide dismutase 1	Homo sapiens	70-74
24066782-2	2013	Deamidation is, nonetheless, chemically equivalent to Asn-to-Asp missense mutations in SOD1 that cause amyotrophic lateral sclerosis (ALS).	Aspartic Acid	61-64	superoxide dismutase 1	Homo sapiens	87-91
24066782-4	2013	Site-directed mutagenesis was used to successively substitute these asparagines with aspartate (to mimic deamidation) according to their predicted deamidation rate, yielding: N26D, N26D/N131D, and N26D/N131D/N139D SOD1.	Aspartic Acid	85-94	superoxide dismutase 1	Homo sapiens	214-218
24116162-3	2013	These differences may be due to a specific residue associated with the MIDAS, particularly the beta3 residue Ala(252) and corresponding Ala in the beta1 integrin compared to the analogous Asp residue in the beta2 and beta7 integrins.	Aspartic Acid	188-191	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	207-212
24133485-0	2013	De novo Synthesis of Glial Glutamate and Glutamine in Young Mice Requires Aspartate Provided by the Neuronal Mitochondrial Aspartate-Glutamate Carrier Aralar/AGC1.	Aspartic Acid	74-83	aggrecan	Mus musculus	158-162
24133485-0	2013	De novo Synthesis of Glial Glutamate and Glutamine in Young Mice Requires Aspartate Provided by the Neuronal Mitochondrial Aspartate-Glutamate Carrier Aralar/AGC1.	Aspartic Acid	123-132	aggrecan	Mus musculus	158-162
24139043-5	2013	ASNS encodes asparagine synthetase, which catalyzes the synthesis of asparagine from glutamine and aspartate.	Aspartic Acid	99-108	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-4
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Aspartic Acid	151-154	endothelin 3	Homo sapiens	45-49
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Aspartic Acid	151-154	PCNA clamp associated factor	Homo sapiens	88-91
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Aspartic Acid	151-154	PCNA clamp associated factor	Homo sapiens	186-189
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Aspartic Acid	151-154	PCNA clamp associated factor	Homo sapiens	186-189
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Aspartic Acid	151-154	PCNA clamp associated factor	Homo sapiens	186-189
24113186-10	2013	Vice versa, a c-Jun mutant bearing aspartate substitution of T95 overwhelmed lithium-mediate protection of CGCs from TK-deprivation, validating that inhibition of T91/T93/T95 phosphorylation underlies the effect of lithium on cell death.	Aspartic Acid	35-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
24007662-6	2013	The concomitant down-regulation of all participating proteins (SLC25A11, SLC25A12, GOT2 and MDH2) of malate-aspartate shuttle might be responsible for the metabolic in-coordination between the cytosol and mitochondria resulting in the failure of energy metabolism.	Aspartic Acid	108-117	solute carrier family 25 member 11	Homo sapiens	63-71
24007662-6	2013	The concomitant down-regulation of all participating proteins (SLC25A11, SLC25A12, GOT2 and MDH2) of malate-aspartate shuttle might be responsible for the metabolic in-coordination between the cytosol and mitochondria resulting in the failure of energy metabolism.	Aspartic Acid	108-117	solute carrier family 25 member 12	Homo sapiens	73-81
24007662-6	2013	The concomitant down-regulation of all participating proteins (SLC25A11, SLC25A12, GOT2 and MDH2) of malate-aspartate shuttle might be responsible for the metabolic in-coordination between the cytosol and mitochondria resulting in the failure of energy metabolism.	Aspartic Acid	108-117	glutamic-oxaloacetic transaminase 2	Homo sapiens	83-87
24007662-6	2013	The concomitant down-regulation of all participating proteins (SLC25A11, SLC25A12, GOT2 and MDH2) of malate-aspartate shuttle might be responsible for the metabolic in-coordination between the cytosol and mitochondria resulting in the failure of energy metabolism.	Aspartic Acid	108-117	malate dehydrogenase 2	Homo sapiens	92-96
23974721-5	2013	In the current study, we indicated that DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked (DDX3X) is an immunogenic protein preferentially expressed in CD133(+) tumor cells.	Aspartic Acid	48-51	DEAD-box helicase 3 X-linked	Homo sapiens	98-103
23947766-1	2013	Protein l-isoaspartyl methyltransferase (PIMT) repairs the isoaspartyl residues (isoAsp) that originate from asparagine deamidation and aspartic acid (Asp) isomerization to Asp residues.	Aspartic Acid	136-149	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	0-39
23947766-1	2013	Protein l-isoaspartyl methyltransferase (PIMT) repairs the isoaspartyl residues (isoAsp) that originate from asparagine deamidation and aspartic acid (Asp) isomerization to Asp residues.	Aspartic Acid	136-149	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	41-45
23947766-1	2013	Protein l-isoaspartyl methyltransferase (PIMT) repairs the isoaspartyl residues (isoAsp) that originate from asparagine deamidation and aspartic acid (Asp) isomerization to Asp residues.	Aspartic Acid	84-87	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	0-39
23947766-1	2013	Protein l-isoaspartyl methyltransferase (PIMT) repairs the isoaspartyl residues (isoAsp) that originate from asparagine deamidation and aspartic acid (Asp) isomerization to Asp residues.	Aspartic Acid	84-87	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	41-45
23947766-1	2013	Protein l-isoaspartyl methyltransferase (PIMT) repairs the isoaspartyl residues (isoAsp) that originate from asparagine deamidation and aspartic acid (Asp) isomerization to Asp residues.	Aspartic Acid	151-154	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	0-39
23947766-1	2013	Protein l-isoaspartyl methyltransferase (PIMT) repairs the isoaspartyl residues (isoAsp) that originate from asparagine deamidation and aspartic acid (Asp) isomerization to Asp residues.	Aspartic Acid	151-154	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	41-45
23842113-5	2013	In vitro biochemical experiments showed that the GH3.5 protein could catalyze the conjugation of SA with aspartic acid to form SA-Asp.	Aspartic Acid	105-118	Auxin-responsive GH3 family protein	Arabidopsis thaliana	49-54
24100308-5	2013	Like the 4-HBA-CoA thioesterases, the DHNA-CoA thioesterases contain either an active-site aspartate (Slr0204) or glutamate (AtDHNAT1) that are predicted to be catalytically important.	Aspartic Acid	91-100	Thioesterase superfamily protein	Arabidopsis thaliana	125-133
23974721-5	2013	In the current study, we indicated that DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked (DDX3X) is an immunogenic protein preferentially expressed in CD133(+) tumor cells.	Aspartic Acid	60-63	DEAD-box helicase 3 X-linked	Homo sapiens	98-103
23904252-2	2013	The formation of Abeta fibrils and oligomers requires a conformational change from an alpha-helix to a beta-sheet conformation, which is encouraged by the formation of a salt bridge between Asp 23 or Glu 22 and Lys 28.	Aspartic Acid	190-193	amyloid beta precursor protein	Homo sapiens	17-22
23910316-4	2013	Under the optimized operating conditions, the L-aspartic acid imprinted modified electrode showed a wide linear response for L-aspartic acid within the concentration range 9.98-532.72 ng mL(-1), with the minimum detection limit of 1.73-1.79 ng mL(-1) (S/N=3) in aqueous and real samples.	Aspartic Acid	46-61	L1 cell adhesion molecule	Mus musculus	187-193
23910316-4	2013	Under the optimized operating conditions, the L-aspartic acid imprinted modified electrode showed a wide linear response for L-aspartic acid within the concentration range 9.98-532.72 ng mL(-1), with the minimum detection limit of 1.73-1.79 ng mL(-1) (S/N=3) in aqueous and real samples.	Aspartic Acid	46-61	L1 cell adhesion molecule	Mus musculus	244-250
23910316-4	2013	Under the optimized operating conditions, the L-aspartic acid imprinted modified electrode showed a wide linear response for L-aspartic acid within the concentration range 9.98-532.72 ng mL(-1), with the minimum detection limit of 1.73-1.79 ng mL(-1) (S/N=3) in aqueous and real samples.	Aspartic Acid	125-140	L1 cell adhesion molecule	Mus musculus	187-193
23910316-4	2013	Under the optimized operating conditions, the L-aspartic acid imprinted modified electrode showed a wide linear response for L-aspartic acid within the concentration range 9.98-532.72 ng mL(-1), with the minimum detection limit of 1.73-1.79 ng mL(-1) (S/N=3) in aqueous and real samples.	Aspartic Acid	125-140	L1 cell adhesion molecule	Mus musculus	244-250
23910316-5	2013	Almost similar stringent limit (1.79 ng mL(-1)) was obtained with cerebrospinal fluid which is typical for the primitive diagnosis of neurological disorders, caused by an acute depletion of L-aspartic acid biomarker, in clinical settings.	Aspartic Acid	190-205	L1 cell adhesion molecule	Mus musculus	40-46
23359565-7	2013	RESULTS: It was found that Glu/Glu, Glu/Asp, and Asp/Asp genotype frequencies of the eNOS gene polymorphism were 35.2%, 59.2%, and 5.6% of the control group, and 32.9%, 65.1%, and 2.0% of the patient group, respectively (P &gt; 0.05).	Aspartic Acid	49-52	nitric oxide synthase 3	Homo sapiens	85-89
23359565-7	2013	RESULTS: It was found that Glu/Glu, Glu/Asp, and Asp/Asp genotype frequencies of the eNOS gene polymorphism were 35.2%, 59.2%, and 5.6% of the control group, and 32.9%, 65.1%, and 2.0% of the patient group, respectively (P &gt; 0.05).	Aspartic Acid	49-52	nitric oxide synthase 3	Homo sapiens	85-89
23609930-1	2013	Human cytosolic aspartyl-tRNA synthetase (DRS) catalyzes the attachment of the amino acid aspartic acid to its cognate tRNA and it is a component of the multi-tRNA synthetase complex (MSC) which has been known to be involved in unexpected signaling pathways.	Aspartic Acid	90-103	sushi repeat containing protein X-linked	Homo sapiens	42-45
23861372-4	2013	To generate a mouse model for the human disease, we have introduced an aspartic acid to glycine mutation in amino acid residue 582 (D582G) of the mouse LHR gene corresponding to the most common D578G mutation found in boys with familial male-limited precocious puberty (FMPP).	Aspartic Acid	71-84	luteinizing hormone/choriogonadotropin receptor	Mus musculus	152-155
23902829-8	2013	The mutation of two amino acids in the CDR2 region to arginine and/or aspartic acid increased the affinity by decreasing the dissociation rate.	Aspartic Acid	70-83	cerebellar degeneration related protein 2	Homo sapiens	39-43
23904252-11	2013	Then, ligands that bind Asp 23 or Glu 22 and Lys 28 could therefore be used to prevent beta turn formation and, consequently, the formation of Abeta fibrils.	Aspartic Acid	24-27	amyloid beta precursor protein	Homo sapiens	143-148
27873629-9	2013	In conclusion, all PHTs have implemented an ASP, although significant differences exist between trusts.	Aspartic Acid	44-47	LY6/PLAUR domain containing 1	Homo sapiens	19-23
23798677-5	2013	We also show that mutation of Asp-101, the intermolecular salt bridge partner of Lys-99, similarly blocks transformation of NIH3T3 cells by EN, reduces EN tyrosine phosphorylation, inhibits Akt and Mek1/2 signaling downstream of EN, and abolishes tumor formation in nude mice.	Aspartic Acid	30-33	thymoma viral proto-oncogene 1	Mus musculus	190-193
23798677-5	2013	We also show that mutation of Asp-101, the intermolecular salt bridge partner of Lys-99, similarly blocks transformation of NIH3T3 cells by EN, reduces EN tyrosine phosphorylation, inhibits Akt and Mek1/2 signaling downstream of EN, and abolishes tumor formation in nude mice.	Aspartic Acid	30-33	mitogen-activated protein kinase kinase 1	Mus musculus	198-204
24069319-1	2013	BACKGROUND: The human SLC25A13 gene encodes citrin, the liver-type mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), and SLC25A13 mutations cause citrin deficiency (CD), a disease entity that encompasses different age-dependant clinical phenotypes such as Adult-onset Citrullinemia Type II (CTLN2) and Neonatal Intrahepatic Cholestasis caused by Citrin Deficiency (NICCD).	Aspartic Acid	81-90	solute carrier family 25 member 13	Homo sapiens	22-30
23909240-3	2013	It is well established that frataxin can coordinate iron using glutamate and aspartate side chains on the protein surface; however, in this work we identify a new iron coordinating residue in the N-terminus of human frataxin using complementary spectroscopic and structural approaches.	Aspartic Acid	77-86	frataxin	Homo sapiens	28-36
23909240-3	2013	It is well established that frataxin can coordinate iron using glutamate and aspartate side chains on the protein surface; however, in this work we identify a new iron coordinating residue in the N-terminus of human frataxin using complementary spectroscopic and structural approaches.	Aspartic Acid	77-86	frataxin	Homo sapiens	216-224
23849427-0	2013	Asp residues of the Glu-Glu-Asp-Asp pore filter contribute to ion permeation and selectivity of the Ca(v)3.2 T-type channel.	Aspartic Acid	0-3	immunoglobulin lambda variable 7-43	Homo sapiens	100-108
23849427-0	2013	Asp residues of the Glu-Glu-Asp-Asp pore filter contribute to ion permeation and selectivity of the Ca(v)3.2 T-type channel.	Aspartic Acid	28-31	immunoglobulin lambda variable 7-43	Homo sapiens	100-108
23849427-0	2013	Asp residues of the Glu-Glu-Asp-Asp pore filter contribute to ion permeation and selectivity of the Ca(v)3.2 T-type channel.	Aspartic Acid	28-31	immunoglobulin lambda variable 7-43	Homo sapiens	100-108
23849427-3	2013	We here investigate how the Asp residues at the pore loops of domains III and IV affect biophysical properties of the Ca(v)3.2 channel.	Aspartic Acid	28-31	immunoglobulin lambda variable 7-43	Homo sapiens	118-126
23849427-4	2013	Electrophysiological characterization of the pore mutant channels in which the pore Asp residue(s) were replaced with Glu, showed that both Asp residues critically control the biophysical properties of Ca(v)3.2, including relative permeability between Ba2+ and Ca2+, anomalous mole fraction effect (AMFE), voltage dependency of channel activation, Cd2+ blocking sensitivity, and pH effects, in distinctive ways.	Aspartic Acid	84-87	immunoglobulin lambda variable 7-43	Homo sapiens	202-210
23849427-4	2013	Electrophysiological characterization of the pore mutant channels in which the pore Asp residue(s) were replaced with Glu, showed that both Asp residues critically control the biophysical properties of Ca(v)3.2, including relative permeability between Ba2+ and Ca2+, anomalous mole fraction effect (AMFE), voltage dependency of channel activation, Cd2+ blocking sensitivity, and pH effects, in distinctive ways.	Aspartic Acid	140-143	immunoglobulin lambda variable 7-43	Homo sapiens	202-210
23959866-4	2013	The PINK1:EED/WAIT1 physical interaction was mediated by the PINK1 kinase domain and the EED/WAIT1 40 amino acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1 in vitro.	Aspartic Acid	140-149	PTEN induced kinase 1	Homo sapiens	4-9
23959866-4	2013	The PINK1:EED/WAIT1 physical interaction was mediated by the PINK1 kinase domain and the EED/WAIT1 40 amino acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1 in vitro.	Aspartic Acid	140-149	embryonic ectoderm development	Homo sapiens	10-13
23959866-4	2013	The PINK1:EED/WAIT1 physical interaction was mediated by the PINK1 kinase domain and the EED/WAIT1 40 amino acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1 in vitro.	Aspartic Acid	140-149	embryonic ectoderm development	Homo sapiens	14-19
23959866-4	2013	The PINK1:EED/WAIT1 physical interaction was mediated by the PINK1 kinase domain and the EED/WAIT1 40 amino acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1 in vitro.	Aspartic Acid	140-149	embryonic ectoderm development	Homo sapiens	89-92
23959866-4	2013	The PINK1:EED/WAIT1 physical interaction was mediated by the PINK1 kinase domain and the EED/WAIT1 40 amino acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1 in vitro.	Aspartic Acid	140-149	embryonic ectoderm development	Homo sapiens	93-98
23959866-4	2013	The PINK1:EED/WAIT1 physical interaction was mediated by the PINK1 kinase domain and the EED/WAIT1 40 amino acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1 in vitro.	Aspartic Acid	140-149	embryonic ectoderm development	Homo sapiens	89-92
23959866-4	2013	The PINK1:EED/WAIT1 physical interaction was mediated by the PINK1 kinase domain and the EED/WAIT1 40 amino acid ending with tryptophan and aspartate (WD40)-repeat region, and PINK1 phosphorylated EED/WAIT1 in vitro.	Aspartic Acid	140-149	embryonic ectoderm development	Homo sapiens	93-98
25702411-1	2013	Linear hepta-peptide Cys-Lys-Gly-Asp-Trp-Asp-Cys was synthesized first and then disulfide bond was formed between the Cys1 and Cys7 to develop cyclo-heptapeptide containing Lys-Gly-Asp-sequence.	Aspartic Acid	33-36	cystin 1	Homo sapiens	118-122
25702411-1	2013	Linear hepta-peptide Cys-Lys-Gly-Asp-Trp-Asp-Cys was synthesized first and then disulfide bond was formed between the Cys1 and Cys7 to develop cyclo-heptapeptide containing Lys-Gly-Asp-sequence.	Aspartic Acid	41-44	cystin 1	Homo sapiens	118-122
22612714-6	2013	The carnitine, citrate, and formate excretion in urine appeared to be higher in the healthy children, while the NSCL/P group excreted higher concentrations of aspartic acid and phenylalanine in urine.	Aspartic Acid	159-172	nescient helix-loop-helix 1	Homo sapiens	112-116
23532923-7	2013	Individuals with an HLA-B allele with an aspartate at residue 114 and the tapasin G allele were more likely to spontaneously resolve HCV infection (P &lt; 0.00003, OR = 3.2 95% CI = 1.6-6.6).	Aspartic Acid	41-50	major histocompatibility complex, class I, B	Homo sapiens	20-25
23532923-8	2013	Additionally, individuals with chronic HCV and the combination of an HLA-B allele with an aspartate at residue 114 and the tapasin G allele also had stronger CD8+ T-cell responses (P = 0.02, OR = 2.58, 95% CI-1.05-6.5).	Aspartic Acid	90-99	major histocompatibility complex, class I, B	Homo sapiens	69-74
23733110-1	2013	BACKGROUND: A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA.	Aspartic Acid	88-101	asporin	Homo sapiens	120-127
23777617-3	2013	Transferrin from human plasma was trapped by membrane-immobilized anti-transferrin antibody, which was produced by non-denaturing two-dimensional electrophoresis (2-DE), and transferred to a polyvinylidene fluoride (PVDF) membrane and stained with Ponceau S. The antigen transferrin was eluted by rinsing the membrane with trifluoroacetic acid (TFA) or aspartic acid.	Aspartic Acid	353-366	transferrin	Homo sapiens	0-11
23777617-3	2013	Transferrin from human plasma was trapped by membrane-immobilized anti-transferrin antibody, which was produced by non-denaturing two-dimensional electrophoresis (2-DE), and transferred to a polyvinylidene fluoride (PVDF) membrane and stained with Ponceau S. The antigen transferrin was eluted by rinsing the membrane with trifluoroacetic acid (TFA) or aspartic acid.	Aspartic Acid	353-366	transferrin	Homo sapiens	71-82
23733110-1	2013	BACKGROUND: A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA.	Aspartic Acid	88-101	asporin	Homo sapiens	129-133
23888046-2	2013	In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium.	Aspartic Acid	147-156	glutamyl aminopeptidase	Homo sapiens	56-72
23867359-6	2013	Active metchnikowin was released by cleavage of the Asp-Pro bond between fused proteins by 72-h formic acid hydrolysis at 50 C. After 24-h dialysis, metchnikowin was purified to electrophoretic homogeneity and showed significant antibacterial activities against both Bacillus subtilis and E. coli DH5alpha.	Aspartic Acid	52-55	Metchnikowin	Drosophila melanogaster	7-19
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Aspartic Acid	127-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Aspartic Acid	127-130	erb-b2 receptor tyrosine kinase 3	Homo sapiens	104-108
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Aspartic Acid	127-130	erb-b2 receptor tyrosine kinase 3	Homo sapiens	104-108
23888046-2	2013	In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium.	Aspartic Acid	147-156	glutamyl aminopeptidase	Homo sapiens	74-77
23853097-6	2013	The complementarity-determining region loops H1, H2, H3, and L3 form a pocket to accommodate the epitope on the RTA (residues Asp(96)-Thr(116)).	Aspartic Acid	126-129	H1.5 linker histone, cluster member	Homo sapiens	45-63
23888046-2	2013	In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium.	Aspartic Acid	147-156	angiotensinogen	Homo sapiens	194-208
23853097-6	2013	The complementarity-determining region loops H1, H2, H3, and L3 form a pocket to accommodate the epitope on the RTA (residues Asp(96)-Thr(116)).	Aspartic Acid	126-129	RNA binding fox-1 homolog 2	Homo sapiens	112-115
23986233-0	2013	Calcium-regulation of mitochondrial respiration maintains ATP homeostasis and requires ARALAR/AGC1-malate aspartate shuttle in intact cortical neurons.	Aspartic Acid	106-115	aggrecan	Mus musculus	94-98
23848432-4	2013	Pim1 recognizes peptide substrates of the consensus RXR(H/R)X(S/T); it accepts essentially any amino acid at the S/T-2 and S/T+1 positions, but strongly disfavors acidic residues (Asp or Glu) at the S/T-2 position and a proline residue at the S/T+1 position.	Aspartic Acid	180-183	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
23828237-5	2013	Cx43CT phospho-mimetic isoforms, which have Asp substitutions at specific Ser/Tyr sites, revealed phosphorylation alters the alpha-helical content of the Cx43CT domain only when attached to the membrane.	Aspartic Acid	44-47	gap junction protein alpha 1	Homo sapiens	0-4
23792041-2	2013	We recently reported that synthetic biotinylated peptides having a Tyr-Lys-Asp-Gly sequence inhibit PAF-induced inflammation by directly binding to PAF.	Aspartic Acid	75-78	PCNA clamp associated factor	Rattus norvegicus	100-103
23824189-6	2013	Dephosphorylation of Aly1 by calcineurin at a subset of phospho-sites is required for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the vacuole, but it does not alter Rsp5 binding, ubiquitinylation, or stability of Aly1.	Aspartic Acid	119-132	Aly1p	Saccharomyces cerevisiae S288C	21-25
23824189-6	2013	Dephosphorylation of Aly1 by calcineurin at a subset of phospho-sites is required for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the vacuole, but it does not alter Rsp5 binding, ubiquitinylation, or stability of Aly1.	Aspartic Acid	119-132	Aly1p	Saccharomyces cerevisiae S288C	86-90
23824189-6	2013	Dephosphorylation of Aly1 by calcineurin at a subset of phospho-sites is required for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the vacuole, but it does not alter Rsp5 binding, ubiquitinylation, or stability of Aly1.	Aspartic Acid	119-132	Dip5p	Saccharomyces cerevisiae S288C	163-167
23824189-6	2013	Dephosphorylation of Aly1 by calcineurin at a subset of phospho-sites is required for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the vacuole, but it does not alter Rsp5 binding, ubiquitinylation, or stability of Aly1.	Aspartic Acid	119-132	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	206-210
23824189-6	2013	Dephosphorylation of Aly1 by calcineurin at a subset of phospho-sites is required for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the vacuole, but it does not alter Rsp5 binding, ubiquitinylation, or stability of Aly1.	Aspartic Acid	119-132	Aly1p	Saccharomyces cerevisiae S288C	86-90
23792041-2	2013	We recently reported that synthetic biotinylated peptides having a Tyr-Lys-Asp-Gly sequence inhibit PAF-induced inflammation by directly binding to PAF.	Aspartic Acid	75-78	PCNA clamp associated factor	Rattus norvegicus	148-151
23792041-7	2013	These results provide evidence that the Tyr-Lys-Asp region in both ET-3 and BPET3 is essential for marked inhibition of the peptide on PAF-induced inflammation, and strongly suggest that BPET3 may be useful as a novel anti-inflammatory drug targeting PAF.	Aspartic Acid	48-51	PCNA clamp associated factor	Rattus norvegicus	135-138
23792041-7	2013	These results provide evidence that the Tyr-Lys-Asp region in both ET-3 and BPET3 is essential for marked inhibition of the peptide on PAF-induced inflammation, and strongly suggest that BPET3 may be useful as a novel anti-inflammatory drug targeting PAF.	Aspartic Acid	48-51	PCNA clamp associated factor	Rattus norvegicus	251-254
23803742-9	2013	A variant of ATP7B in which the aspartate 1027 residue in the phosphorylation domain was converted to glutamine localized to the TGN but was incapable of cDDP-induced trafficking.	Aspartic Acid	32-41	ATPase copper transporting beta	Homo sapiens	13-18
23770703-8	2013	In contrast to (HUMAN) NAT2, the presence of a Glu or Asp in the triad of (BACCR)NAT3 did not significantly affect enzyme structure or function.	Aspartic Acid	54-57	N-alpha-acetyltransferase 20, NatB catalytic subunit	Homo sapiens	81-85
23711960-6	2013	Dominant-negative inhibition on endogenous PTP1B by lentivirus-mediated overexpression of PTP1B double mutant in Tyr-46 and Asp-181 residues (LV-D/A-Y/F) also stimulated adipogenesis, more efficient than PTP1B knockdown.	Aspartic Acid	124-127	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	43-48
23711960-6	2013	Dominant-negative inhibition on endogenous PTP1B by lentivirus-mediated overexpression of PTP1B double mutant in Tyr-46 and Asp-181 residues (LV-D/A-Y/F) also stimulated adipogenesis, more efficient than PTP1B knockdown.	Aspartic Acid	124-127	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	90-95
23711960-6	2013	Dominant-negative inhibition on endogenous PTP1B by lentivirus-mediated overexpression of PTP1B double mutant in Tyr-46 and Asp-181 residues (LV-D/A-Y/F) also stimulated adipogenesis, more efficient than PTP1B knockdown.	Aspartic Acid	124-127	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	90-95
23754197-4	2013	We demonstrated that Asp induced cell death through the activation of TRAIL DR4/DR5 death receptors leading to the activation of caspase-8 and caspase-3 and to cell apoptosis.	Aspartic Acid	21-24	TNF superfamily member 10	Homo sapiens	70-75
23754197-4	2013	We demonstrated that Asp induced cell death through the activation of TRAIL DR4/DR5 death receptors leading to the activation of caspase-8 and caspase-3 and to cell apoptosis.	Aspartic Acid	21-24	major histocompatibility complex, class II, DR beta 4	Homo sapiens	76-79
23754197-4	2013	We demonstrated that Asp induced cell death through the activation of TRAIL DR4/DR5 death receptors leading to the activation of caspase-8 and caspase-3 and to cell apoptosis.	Aspartic Acid	21-24	TNF receptor superfamily member 10b	Homo sapiens	80-83
23754197-4	2013	We demonstrated that Asp induced cell death through the activation of TRAIL DR4/DR5 death receptors leading to the activation of caspase-8 and caspase-3 and to cell apoptosis.	Aspartic Acid	21-24	caspase 8	Homo sapiens	129-138
23754197-4	2013	We demonstrated that Asp induced cell death through the activation of TRAIL DR4/DR5 death receptors leading to the activation of caspase-8 and caspase-3 and to cell apoptosis.	Aspartic Acid	21-24	caspase 3	Homo sapiens	143-152
23754197-6	2013	We found also that Asp (80 microg/ml) was able to potentiate the effects of the cytokine TRAIL on cell death even in the TRAIL-resistant metastatic SW620 cells.	Aspartic Acid	19-22	TNF superfamily member 10	Homo sapiens	89-94
23754197-6	2013	We found also that Asp (80 microg/ml) was able to potentiate the effects of the cytokine TRAIL on cell death even in the TRAIL-resistant metastatic SW620 cells.	Aspartic Acid	19-22	TNF superfamily member 10	Homo sapiens	121-126
23754197-11	2013	In the colonic mucosa of Asp-treated rats we also confirmed the pro-apoptotic effects observed in vitro including the activation of the TRAIL death-receptor signaling pathway.	Aspartic Acid	25-28	TNF superfamily member 10	Homo sapiens	136-141
23824562-3	2013	This work presents preformulation characterization data on the effect of pH, NaCl concentration, and various cationic excipients on the physical and chemical stability of a Fab molecule with multiple negatively charged Asp residues in the complementarity-determining region.	Aspartic Acid	219-222	FA complementation group B	Homo sapiens	173-176
23763587-7	2013	In confluent HEK-hOCT2-C, largely different inhibitor potencies were obtained upon comparison of inhibition of Cd(2+) uptake, 4-[4-(dimethylamino)styryl]-N-methylpyridinium(+) (ASP(+)) uptake, and MPP(+) uptake using substrate concentrations far below the respective Km values.	Aspartic Acid	177-183	solute carrier family 22 member 2	Homo sapiens	17-22
23770703-3	2013	Indeed, in (HUMAN)NAT2 variants, mutation of the Asp residue to Asn, Gln, or Glu dramatically impairs enzyme activity.	Aspartic Acid	49-52	N-acetyltransferase 2	Homo sapiens	18-22
23894621-0	2013	A conserved aspartic acid is important for agonist (VUAA1) and odorant/tuning receptor-dependent activation of the insect odorant co-receptor (Orco).	Aspartic Acid	12-25	Odorant receptor co-receptor	Drosophila melanogaster	122-141
23909421-5	2013	Western blot analysis using deletion mutants revealed that the epitope was located within a region between Asp(303) and Leu(320) in the C-terminal tail of AQP4.	Aspartic Acid	107-110	aquaporin 4	Homo sapiens	155-159
23936151-6	2013	Sequencing of candidate gene TECTA revealed a heterozygous c.5945C&gt;A substitution in exon 19, causing amino acid substitution of Ala to Asp at a conservative position 1982.	Aspartic Acid	139-142	tectorin alpha	Homo sapiens	29-34
23749999-4	2013	Cleavage of JunB at aspartic acid 137 separates the N-terminal transactivation domain from the C-terminal DNA binding and dimerization domains, and we show that the C-terminal cleavage fragment retains both DNA binding activity and the ability to interact with AP-1 family transcription factors.	Aspartic Acid	20-33	jun B proto-oncogene	Mus musculus	12-16
23772836-1	2013	The HLA-A*33:44 allele differs from HLA-A*33:03:01 by a single mutation at position 866 (G A), at codon 265 (GGT GAT) in exon4 (Gly Asp).	Aspartic Acid	132-135	major histocompatibility complex, class I, A	Homo sapiens	4-9
23894621-0	2013	A conserved aspartic acid is important for agonist (VUAA1) and odorant/tuning receptor-dependent activation of the insect odorant co-receptor (Orco).	Aspartic Acid	12-25	Odorant receptor co-receptor	Drosophila melanogaster	143-147
23754285-4	2013	The active site of ADAMDEC1 is unique by being the only mammalian ADAM protease with a non-histidine zinc ligand, having an aspartic acid residue instead.	Aspartic Acid	124-137	ADAM like decysin 1	Homo sapiens	19-27
23709221-1	2013	Previous studies have identified two salt bridges in human CFTR chloride ion channels, Arg(352)-Asp(993) and Arg(347)-Asp(924), that are required for normal channel function.	Aspartic Acid	96-99	CF transmembrane conductance regulator	Homo sapiens	59-63
23651062-2	2013	The F-box protein, FBW2 (F-box and WD-repeat domain-containing 2), which contains five WD (tryptophan-aspartate) repeats, recognizes GCM1 and mediates its ubiquitination via the SCFFBW2 E3 ligase complex.	Aspartic Acid	102-111	F-box and WD repeat domain containing 2	Homo sapiens	19-23
23651062-2	2013	The F-box protein, FBW2 (F-box and WD-repeat domain-containing 2), which contains five WD (tryptophan-aspartate) repeats, recognizes GCM1 and mediates its ubiquitination via the SCFFBW2 E3 ligase complex.	Aspartic Acid	102-111	glial cells missing transcription factor 1	Homo sapiens	133-137
23687382-4	2013	Experiments performed with botulinum neurotoxins led to the identification of one arginine residue in SNAP-25 and one aspartate residue in syntaxin (R206 and D253 in Drosophila melanogaster).	Aspartic Acid	118-127	Syntaxin 1A	Drosophila melanogaster	139-147
23709221-1	2013	Previous studies have identified two salt bridges in human CFTR chloride ion channels, Arg(352)-Asp(993) and Arg(347)-Asp(924), that are required for normal channel function.	Aspartic Acid	118-121	CF transmembrane conductance regulator	Homo sapiens	59-63
23923392-6	2013	It showed in minimal clonic seizure (6Hz) test (ASP) in rats after i. p. administration: MES ED50 = 36.5 mg/kg, TOX TD50 = 269.75 mg/kg, and PI = 7.39.	Aspartic Acid	48-51	thymocyte selection-associated high mobility group box	Rattus norvegicus	112-115
23678002-3	2013	Here, we demonstrate that treatment with CDDP resulted in down-regulation of c-Jun expression via caspase-9-dependent cleavage of c-Jun at Asp-65 and MEKK1-mediated ubiquitylation and degradation of c-Jun in CDDP-sensitive cancer cells.	Aspartic Acid	139-142	jun proto-oncogene	Mus musculus	77-82
23678002-3	2013	Here, we demonstrate that treatment with CDDP resulted in down-regulation of c-Jun expression via caspase-9-dependent cleavage of c-Jun at Asp-65 and MEKK1-mediated ubiquitylation and degradation of c-Jun in CDDP-sensitive cancer cells.	Aspartic Acid	139-142	caspase 9	Mus musculus	98-107
23678002-3	2013	Here, we demonstrate that treatment with CDDP resulted in down-regulation of c-Jun expression via caspase-9-dependent cleavage of c-Jun at Asp-65 and MEKK1-mediated ubiquitylation and degradation of c-Jun in CDDP-sensitive cancer cells.	Aspartic Acid	139-142	jun proto-oncogene	Mus musculus	130-135
23798402-3	2013	The 1.48-A resolution crystal structure of MLL5 plant homeodomain in complex with the H3K4me3 peptide reveals a noncanonical binding mechanism, whereby K4me3 is recognized through a single aromatic residue and an aspartate.	Aspartic Acid	213-222	lysine methyltransferase 2E (inactive)	Homo sapiens	43-47
23678002-3	2013	Here, we demonstrate that treatment with CDDP resulted in down-regulation of c-Jun expression via caspase-9-dependent cleavage of c-Jun at Asp-65 and MEKK1-mediated ubiquitylation and degradation of c-Jun in CDDP-sensitive cancer cells.	Aspartic Acid	139-142	jun proto-oncogene	Mus musculus	130-135
23844040-8	2013	Cells expressing a Phospho-mimicking point mutant RP1-ASP(236) show a marked decrease of adhesion to endothelial cells under shear stress.	Aspartic Acid	54-57	RP1 axonemal microtubule associated	Homo sapiens	50-53
23868210-4	2013	PEGylated Ac-Trp-[Cit(11,18),hArg(24),Lys(25),Asp(31),Pro(34),1-Nal(35)]CGRP(8-37)-NH2, 9, elicits a dose-dependent reduction of intradermal CGRP-induced local blood flow in rodents with an ED50 of 0.52 mg kg(-1) without any overt adverse effects.	Aspartic Acid	46-49	calcitonin related polypeptide alpha	Homo sapiens	72-76
23449734-8	2013	Interestingly, the integrin-blocking peptide Arg-Gly-Asp-Ser, as well as integrin alpha5beta1 function-blocking antibodies, inhibited the effects of TGF-beta1 and its combination with methacholine on cell proliferation.	Aspartic Acid	53-56	transforming growth factor beta 1	Homo sapiens	149-158
23688511-10	2013	Substitution of the asparagine at position 417 with structurally related amino acids such as an aspartate and a glutamine also abolished the dimerization of TNSALP without perturbing its cell surface localization.	Aspartic Acid	96-105	alkaline phosphatase, biomineralization associated	Homo sapiens	157-163
23313986-6	2013	Consistently with the structural observations, co-immuno-precipitation experiments performed in Nicotiana benthamiana show that the DDL FHA domain co-immuno-precipitates with DCL1 fragments containing the predicted pThr+3(Ile/Val/Leu/Asp) motif.	Aspartic Acid	234-237	SMAD/FHA domain-containing protein	Arabidopsis thaliana	132-135
23680598-5	2013	Combination of both the asparagine-to-aspartate mutations (N157D/N230D) resulted in complete loss of activity on G:5caC while retaining measurable activity on G:U, implying that 5caC can adopt alternative conformations (either N157-interacting or N230-interacting) in the TDG active site to interact with either of the two asparagine side chain for 5caC excision.	Aspartic Acid	38-47	thymine DNA glycosylase	Homo sapiens	272-275
23629537-8	2013	We also found that the system shows maximal Ca(2+)-binding to the CAS (consecutive aspartate stretch at the C-terminus) before the rest of the CASQ1 surface becomes saturated.	Aspartic Acid	83-92	BCAR1 scaffold protein, Cas family member	Homo sapiens	66-69
23785733-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	vitronectin	Mus musculus	31-42
23661698-8	2013	Analysis of Eph/ephrin crystal structures reveals an interaction between the ligand"s carbohydrates and two residues of EphA2: Asp-78 and Lys-136.	Aspartic Acid	127-130	EPH receptor A2	Homo sapiens	120-125
23840430-3	2013	Molecular docking was used to reproduce the crystallographic binding mode of cyclic inosine 5"-diphosphoribose (N1-cIDPR) with CD38, revealing an exploitable pocket and predicting the potential to introduce an extra hydrogen bond interaction with Asp-155.	Aspartic Acid	247-250	CD38 molecule	Homo sapiens	127-131
23840430-5	2013	Crystallography of an 8-amino N1-cIDPR:CD38 complex confirmed the predicted interaction with Asp-155, together with a second H-bond from a realigned Glu-146, rationalizing the improved inhibition (IC50 56 microM).	Aspartic Acid	93-96	CD38 molecule	Homo sapiens	39-43
23338940-0	2013	Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.	Aspartic Acid	31-34	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	21-27
23338940-0	2013	Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.	Aspartic Acid	31-34	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	50-56
24199571-10	2013	Compared with the aging group, ASP could significantly inhibit the cell ratio of in HSC G1 stage and the increase in the number of SA-beta-Gal positive cells, down-regulate the expression of P53 protein, and increase the length of telomere and the vitality of telomerase in HSCs.	Aspartic Acid	31-34	transformation related protein 53, pseudogene	Mus musculus	191-194
24257358-6	2013	All affected individuals were detected with TUBB3 c.1249G &gt; A mutation, the mutation is in exon 4, resulting in wild-type gene encoding the Aspartic acid ( Asp or D ) replaced .by Asparagine (Asn or N ).	Aspartic Acid	143-156	tubulin beta 3 class III	Homo sapiens	44-49
24257358-6	2013	All affected individuals were detected with TUBB3 c.1249G &gt; A mutation, the mutation is in exon 4, resulting in wild-type gene encoding the Aspartic acid ( Asp or D ) replaced .by Asparagine (Asn or N ).	Aspartic Acid	143-146	tubulin beta 3 class III	Homo sapiens	44-49
23825541-15	2013	In conclusion, the antigenic peptide hR32 vaccine mimicking the (32)Asp catalytic site of human renin may constitute a novel tool for the development of a renin vaccine.	Aspartic Acid	68-71	renin	Homo sapiens	96-101
23825541-15	2013	In conclusion, the antigenic peptide hR32 vaccine mimicking the (32)Asp catalytic site of human renin may constitute a novel tool for the development of a renin vaccine.	Aspartic Acid	68-71	renin	Homo sapiens	155-160
23785729-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	vitronectin	Mus musculus	31-42
23609439-1	2013	alpha-Tropomyosin (alpha-TM) has a conserved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is unusual in that the residue is found at a position typically occupied by a hydrophobic residue.	Aspartic Acid	54-57	tropomyosin 1, alpha	Mus musculus	0-17
23609439-1	2013	alpha-Tropomyosin (alpha-TM) has a conserved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is unusual in that the residue is found at a position typically occupied by a hydrophobic residue.	Aspartic Acid	54-57	tropomyosin 1, alpha	Mus musculus	19-27
23589380-1	2013	The aim of this study was to investigate the effect of divalent metal ions (Ca, Mg(2+) , and Zn(2+) ) on the stability of oxytocin in aspartate buffer (pH 4.5) and to determine their interaction with the peptide in aqueous solution.	Aspartic Acid	134-143	oxytocin/neurophysin I prepropeptide	Homo sapiens	122-130
23741768-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Mus musculus	121-132
23379364-3	2013	We investigated the association between a single nucleotide polymorphism in the TRIM5alpha linker 2 region (rs11038628), which substituted aspartic acid (D) for glycine (G) at position 249, with susceptibility to HIV-1 infection in Japanese and Indian subjects.	Aspartic Acid	139-152	tripartite motif containing 5	Homo sapiens	80-90
23589380-2	2013	Reversed-phase high-performance liquid chromatography and high-performance size-exclusion chromatography measurements indicated that after 4 weeks of storage at 55 C, all tested divalent metal ions improved the stability of oxytocin in aspartate-buffered solutions (pH 4.5).	Aspartic Acid	236-245	oxytocin/neurophysin I prepropeptide	Homo sapiens	224-232
23589380-5	2013	As shown by isothermal titration calorimetry, Zn(2+) interacted with oxytocin in the presence of aspartate buffer, whereas Ca(2+) or Mg(2+) did not.	Aspartic Acid	97-106	oxytocin/neurophysin I prepropeptide	Homo sapiens	69-77
23589380-6	2013	In conclusion, the stability of oxytocin in the aspartate-buffered solution is strongly improved in the presence of Zn(2+) , and the stabilization effect is correlated with the ability of the divalent metal ions in aspartate buffer to interact with oxytocin.	Aspartic Acid	48-57	oxytocin/neurophysin I prepropeptide	Homo sapiens	32-40
23589380-6	2013	In conclusion, the stability of oxytocin in the aspartate-buffered solution is strongly improved in the presence of Zn(2+) , and the stabilization effect is correlated with the ability of the divalent metal ions in aspartate buffer to interact with oxytocin.	Aspartic Acid	48-57	oxytocin/neurophysin I prepropeptide	Homo sapiens	249-257
23589380-6	2013	In conclusion, the stability of oxytocin in the aspartate-buffered solution is strongly improved in the presence of Zn(2+) , and the stabilization effect is correlated with the ability of the divalent metal ions in aspartate buffer to interact with oxytocin.	Aspartic Acid	215-224	oxytocin/neurophysin I prepropeptide	Homo sapiens	32-40
23589380-6	2013	In conclusion, the stability of oxytocin in the aspartate-buffered solution is strongly improved in the presence of Zn(2+) , and the stabilization effect is correlated with the ability of the divalent metal ions in aspartate buffer to interact with oxytocin.	Aspartic Acid	215-224	oxytocin/neurophysin I prepropeptide	Homo sapiens	249-257
23651498-2	2013	Integrin alphavbeta3 can be imaged with arginine-glycine-aspartic acid (RGD) peptide agents.	Aspartic Acid	57-70	integrin subunit alpha V	Homo sapiens	0-20
23512522-1	2013	The mammalian Atg16L1 protein consists of a coiled-coil domain and a tryptophan-aspartic acid (WD) repeat domain and is involved in the process of autophagy.	Aspartic Acid	80-93	autophagy related 16 like 1	Homo sapiens	14-21
23620283-6	2013	Ongoing muscle differentiation is accompanied by elevated caspase activity, which results in caspase-mediated cleavage of HIPK2 following aspartic acids 916 and 977 and the generation of a C-terminally truncated HIPK2 protein.	Aspartic Acid	138-152	homeodomain interacting protein kinase 2	Homo sapiens	122-127
23744324-3	2013	RESULTS: A novel c.956 A&gt;T resulting in substitution of Aspartic acid 319 for Valine (p.Asp319Val) has been identified in exon 9 of the COMP gene in the patient.	Aspartic Acid	59-72	cartilage oligomeric matrix protein	Homo sapiens	139-143
23720861-16	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	vitronectin	Homo sapiens	31-42
23720861-16	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	fibrinogen beta chain	Homo sapiens	44-54
23660814-7	2013	The residues Asp 7 and Ser 8 of Abeta-peptide were found in close contact with Glu 384 of tACE along with Zn(2+).	Aspartic Acid	13-16	amyloid beta precursor protein	Homo sapiens	32-37
23660814-7	2013	The residues Asp 7 and Ser 8 of Abeta-peptide were found in close contact with Glu 384 of tACE along with Zn(2+).	Aspartic Acid	13-16	ADAM metallopeptidase domain 17	Homo sapiens	90-94
23660814-8	2013	This study has demonstrated that the residue Glu 384 of tACE might play key role in the degradation of Abeta-peptide by cleaving peptide bond between Asp 7 and Ser 8 residues.	Aspartic Acid	150-153	ADAM metallopeptidase domain 17	Homo sapiens	56-60
23660814-8	2013	This study has demonstrated that the residue Glu 384 of tACE might play key role in the degradation of Abeta-peptide by cleaving peptide bond between Asp 7 and Ser 8 residues.	Aspartic Acid	150-153	amyloid beta precursor protein	Homo sapiens	103-108
23541716-8	2013	Additionally, three novel PTMs in ITIH3 were identified and include hexose-N-acetyl-hexosamine at asparagine-(41), trimethylation at aspartic acid-(290), and flavin adenine dinucleotide at histidine-(335).	Aspartic Acid	133-146	inter-alpha-trypsin inhibitor heavy chain 3	Homo sapiens	34-39
23704982-1	2013	Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of the genetically encoded guanine at the wobble position of tRNAs(His,Tyr,Asp,Asn) by the premodified base preQ1, which is further converted to queuine at the tRNA level.	Aspartic Acid	144-147	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	10-39
23704982-1	2013	Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of the genetically encoded guanine at the wobble position of tRNAs(His,Tyr,Asp,Asn) by the premodified base preQ1, which is further converted to queuine at the tRNA level.	Aspartic Acid	144-147	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	41-44
23369758-4	2013	We found that a significantly increased risk of vitiligo was associated with the APE1 Asp/Glu (adjusted odds ratio (OR) 1.24; 95% confidence interval (CI) 1.02-1.52) and Glu/Glu genotypes (adjusted OR 1.48; 95% CI 1.13-1.93), compared with the APE1 Asp/Asp genotype, whereas no vitiligo risk was associated with the genotypes ADPRT-Val762Ala and XRCC1-Arg399Gln.	Aspartic Acid	86-89	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	81-85
23499736-7	2013	Although CEACAM1 has two ITIMs, they were not tyrosine-phosphorylated upon Fas ligation, indicating an ITIM independent mechanism; however, mutation of the critical residue S508, located between the ITIMs, to aspartic acid and a prerequisite for ITIM activation, abrogates the inhibitory activity of CEACAM1 to Fas-mediated apoptosis.	Aspartic Acid	209-222	CEA cell adhesion molecule 1	Homo sapiens	9-16
23580486-7	2013	RESULTS: An A to G missense mutation at position 518 of the Gnat2 gene was identified that resulted in an aspartic acid to glycine substitution.	Aspartic Acid	106-119	guanine nucleotide binding protein, alpha transducing 2	Mus musculus	60-65
23511633-7	2013	In addition to these SK3 channel basic residues important for sensitivity, two acidic residues, Asp-492 and Asp-518, also located in the SK3 channel outer vestibule, were identified as being critical for toxin affinity.	Aspartic Acid	96-99	potassium calcium-activated channel subfamily N member 3	Homo sapiens	137-140
23511633-7	2013	In addition to these SK3 channel basic residues important for sensitivity, two acidic residues, Asp-492 and Asp-518, also located in the SK3 channel outer vestibule, were identified as being critical for toxin affinity.	Aspartic Acid	108-111	potassium calcium-activated channel subfamily N member 3	Homo sapiens	137-140
23511633-8	2013	Furthermore, molecular modeling data indicate the existence of a compact SK3 channel turret conformation (like a peptide screener), where the basic rings of Arg-485 and Arg-489 are stabilized by strong ionic interactions with Asp-492 and Asp-518.	Aspartic Acid	226-229	potassium calcium-activated channel subfamily N member 3	Homo sapiens	73-76
23511633-8	2013	Furthermore, molecular modeling data indicate the existence of a compact SK3 channel turret conformation (like a peptide screener), where the basic rings of Arg-485 and Arg-489 are stabilized by strong ionic interactions with Asp-492 and Asp-518.	Aspartic Acid	238-241	potassium calcium-activated channel subfamily N member 3	Homo sapiens	73-76
23116563-2	2013	By candidate gene screening, we identified a novel mutation in MIP (c.494 G &gt; A) that segregates with a congenital lamellar cataract within a south Indian family and causes the replacement of a highly conserved glycine by aspartate (G165D) within aquaporin0 (AQP0).	Aspartic Acid	225-234	major intrinsic protein of lens fiber	Homo sapiens	250-260
23116563-2	2013	By candidate gene screening, we identified a novel mutation in MIP (c.494 G &gt; A) that segregates with a congenital lamellar cataract within a south Indian family and causes the replacement of a highly conserved glycine by aspartate (G165D) within aquaporin0 (AQP0).	Aspartic Acid	225-234	major intrinsic protein of lens fiber	Homo sapiens	262-266
23369758-4	2013	We found that a significantly increased risk of vitiligo was associated with the APE1 Asp/Glu (adjusted odds ratio (OR) 1.24; 95% confidence interval (CI) 1.02-1.52) and Glu/Glu genotypes (adjusted OR 1.48; 95% CI 1.13-1.93), compared with the APE1 Asp/Asp genotype, whereas no vitiligo risk was associated with the genotypes ADPRT-Val762Ala and XRCC1-Arg399Gln.	Aspartic Acid	249-252	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	81-85
23369758-4	2013	We found that a significantly increased risk of vitiligo was associated with the APE1 Asp/Glu (adjusted odds ratio (OR) 1.24; 95% confidence interval (CI) 1.02-1.52) and Glu/Glu genotypes (adjusted OR 1.48; 95% CI 1.13-1.93), compared with the APE1 Asp/Asp genotype, whereas no vitiligo risk was associated with the genotypes ADPRT-Val762Ala and XRCC1-Arg399Gln.	Aspartic Acid	249-252	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	81-85
23369758-5	2013	Furthermore, serum 8-OHdG levels were elevated in the APE1-148Glu allele carriers (Asp/Glu+Glu/Glu), in an allele dose-response manner, with the risk of vitiligo (Ptrend&lt;0.05).	Aspartic Acid	83-86	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	54-58
23577985-0	2013	Differential role of the protein matrix on the binding of a catalytic aspartate to Mg2+ vs Ca2+: application to ribonuclease H. Divalent metal cations are essential cofactors for many enzyme functions.	Aspartic Acid	70-79	mucin 7, secreted	Homo sapiens	83-86
23619718-10	2013	Three MUC19 SNPs were nominally significantly associated with CD (rs11564245, Asp His: P = 0.02; rs4768261, Ser Phe: P = 0.0008; and rs2933353, Glu Ala: P = 0.01).	Aspartic Acid	78-81	mucin 19, oligomeric	Homo sapiens	6-11
23640428-4	2013	The pK a values of the BACE-1 acidic residues deviate substantially from the estimates for model compounds in solution and display a ligand dependent variability, especially in the case of the catalytic Asp dyad residues.	Aspartic Acid	203-206	beta-secretase 1	Homo sapiens	23-29
23426954-1	2013	Activation of the cannabinoid CB1 receptor (CB1) is modulated by aspartate residue D2.63(176) in transmembrane helix (TMH) 2.	Aspartic Acid	65-74	cannabinoid receptor 1	Homo sapiens	30-33
23530144-6	2013	Consequently, cell-permeable peptides with a Thr(513) to Ile derivative (protein transduction domain [PTD]-PDK1-Thr(513)-Ile) bound the kinase domain, whereas a Thr(513)-to-Asp peptide (PTD-PDK1-Thr(513)-Asp) bound the PH domain.	Aspartic Acid	204-207	pyruvate dehydrogenase kinase 1	Homo sapiens	107-111
23530144-8	2013	In contrast, PTD-PDK1- Thr(513)-Asp selectively inhibited binding between PDK1 and CARMA1, and blocked TCR/CD28-induced NF-kappaB activation.	Aspartic Acid	32-35	pyruvate dehydrogenase kinase 1	Homo sapiens	17-21
23530144-8	2013	In contrast, PTD-PDK1- Thr(513)-Asp selectively inhibited binding between PDK1 and CARMA1, and blocked TCR/CD28-induced NF-kappaB activation.	Aspartic Acid	32-35	pyruvate dehydrogenase kinase 1	Homo sapiens	74-78
23530144-8	2013	In contrast, PTD-PDK1- Thr(513)-Asp selectively inhibited binding between PDK1 and CARMA1, and blocked TCR/CD28-induced NF-kappaB activation.	Aspartic Acid	32-35	caspase recruitment domain family member 11	Homo sapiens	83-89
23530144-8	2013	In contrast, PTD-PDK1- Thr(513)-Asp selectively inhibited binding between PDK1 and CARMA1, and blocked TCR/CD28-induced NF-kappaB activation.	Aspartic Acid	32-35	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	103-106
23530144-8	2013	In contrast, PTD-PDK1- Thr(513)-Asp selectively inhibited binding between PDK1 and CARMA1, and blocked TCR/CD28-induced NF-kappaB activation.	Aspartic Acid	32-35	CD28 molecule	Homo sapiens	107-111
23530144-6	2013	Consequently, cell-permeable peptides with a Thr(513) to Ile derivative (protein transduction domain [PTD]-PDK1-Thr(513)-Ile) bound the kinase domain, whereas a Thr(513)-to-Asp peptide (PTD-PDK1-Thr(513)-Asp) bound the PH domain.	Aspartic Acid	173-176	pyruvate dehydrogenase kinase 1	Homo sapiens	107-111
23434736-6	2013	The sisters harbour a homozygous in-frame deletion that is predicted to remove a highly conserved aspartic acid residue within the interface where the protein, RhoGDIalpha, interacts with the Rho family of small GTPases (c.553_555del(p.Asp185del)).	Aspartic Acid	98-111	Rho GDP dissociation inhibitor (GDI) alpha	Mus musculus	160-171
23426954-1	2013	Activation of the cannabinoid CB1 receptor (CB1) is modulated by aspartate residue D2.63(176) in transmembrane helix (TMH) 2.	Aspartic Acid	65-74	cannabinoid receptor 1	Homo sapiens	44-47
23427159-7	2013	Induction of autophagy was confirmed by Western blot analyses that showed an ASP-mediated increase in levels of LC3b-II and Beclin 1, as well as colocalization and interaction between ASP and LC3.	Aspartic Acid	77-80	beclin 1	Homo sapiens	124-132
23541585-6	2013	Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuated the nuclear import.	Aspartic Acid	16-19	protein phosphatase 1 regulatory inhibitor subunit 14A	Homo sapiens	36-42
23888782-2	2013	The isomerized at aspartate 7 isoform of the human Abeta (isoAbeta) is the main component of these plaques and is considered as the potential pathogenic agent of AD.	Aspartic Acid	18-27	amyloid beta precursor protein	Homo sapiens	51-56
23357641-1	2013	Nephronectin is a basement membrane protein comprising five N-terminal epidermal growth factor (EGF)-like repeats, a central linker segment containing an Arg-Gly-Asp (RGD) motif and a C-terminal meprin-A5 protein-receptor protein tyrosine phosphatase mu (MAM) domain.	Aspartic Acid	162-165	nephronectin	Mus musculus	0-12
23426967-7	2013	The Ca(2+)-activated TMEM16F currents were anion selective, because replacing Cl(-) with aspartate(-) in the bathing solution without changing cation concentrations caused a positive shift of the reversal potential.	Aspartic Acid	89-98	anoctamin 6	Homo sapiens	21-28
23403946-1	2013	Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction.	Aspartic Acid	57-66	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	0-21
23426967-8	2013	The anion selectivity sequence of the TMEM16F channel was I(-) &gt; Br(-) &gt; Cl(-) &gt; F(-) &gt; aspartate(-).	Aspartic Acid	100-109	anoctamin 6	Homo sapiens	38-45
23403946-1	2013	Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction.	Aspartic Acid	57-66	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	23-27
23510998-2	2013	An aspartate residue critical for KCNE1 function, asp76, is conserved in MPS-4 (asp74).	Aspartic Acid	3-12	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	34-39
23473945-4	2013	The substitutions to naturally occurring tachykinins with Asp and MePhe improved the receptor binding and agonistic activity for NK3R.	Aspartic Acid	58-61	tachykinin receptor 3	Homo sapiens	129-133
23510998-2	2013	An aspartate residue critical for KCNE1 function, asp76, is conserved in MPS-4 (asp74).	Aspartic Acid	3-12	MinK-related peptide, potassium channel accessory subunit protein 4	Caenorhabditis elegans	73-78
23344882-5	2013	Here, we describe a quantitative investigation of isoAsp-formation from N-terminal Asn and Asp using model peptides similar to the Abeta N-terminus.	Aspartic Acid	53-56	amyloid beta precursor protein	Homo sapiens	131-136
23386603-1	2013	Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively.	Aspartic Acid	57-66	caspase 1	Homo sapiens	0-8
23386603-1	2013	Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively.	Aspartic Acid	57-66	caspase 1	Homo sapiens	189-198
23386603-1	2013	Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively.	Aspartic Acid	57-66	caspase 3	Homo sapiens	203-212
23535601-5	2013	Whereas most cells use glutamate dehydrogenase (GLUD1) to convert glutamine-derived glutamate into alpha-ketoglutarate in the mitochondria to fuel the tricarboxylic acid cycle, PDAC relies on a distinct pathway in which glutamine-derived aspartate is transported into the cytoplasm where it can be converted into oxaloacetate by aspartate transaminase (GOT1).	Aspartic Acid	238-247	glutamate dehydrogenase 1	Homo sapiens	48-53
23561520-4	2013	Instead of the common GxxxG dimerization motif, mutating either of the polar residues Asp-50 and Thr-54 significantly decreased the TOXCAT signal for the dimerization of DAP12 TM domain.	Aspartic Acid	86-89	transmembrane immune signaling adaptor TYROBP	Homo sapiens	170-175
23561520-5	2013	Furthermore, through the conformational difference between wild-type and mutant DAP12 TM homodimers, a combined coarse-grained and atomistic molecular dynamics simulation has identified both Asp-50 and Thr-54 at the dimerization interface.	Aspartic Acid	191-194	transmembrane immune signaling adaptor TYROBP	Homo sapiens	80-85
23484851-3	2013	The more hydrophobic polypeptides (Asp1Phe2)n and (Asp1Phe3)n behaved as if the Asp"s were isolated from each other and showed an apparent pKa (pKa(app)) that remained constant with level of ionization (alpha = [Asp(-)]/[Asp]total) and equaled 5.4 and 6.4, respectively.	Aspartic Acid	35-38	amyloid beta precursor protein	Homo sapiens	144-152
23484851-3	2013	The more hydrophobic polypeptides (Asp1Phe2)n and (Asp1Phe3)n behaved as if the Asp"s were isolated from each other and showed an apparent pKa (pKa(app)) that remained constant with level of ionization (alpha = [Asp(-)]/[Asp]total) and equaled 5.4 and 6.4, respectively.	Aspartic Acid	51-54	amyloid beta precursor protein	Homo sapiens	144-152
23484851-3	2013	The more hydrophobic polypeptides (Asp1Phe2)n and (Asp1Phe3)n behaved as if the Asp"s were isolated from each other and showed an apparent pKa (pKa(app)) that remained constant with level of ionization (alpha = [Asp(-)]/[Asp]total) and equaled 5.4 and 6.4, respectively.	Aspartic Acid	51-54	amyloid beta precursor protein	Homo sapiens	144-152
23420846-1	2013	The minimal proton pumping machinery of the Arabidopsis thaliana P-type plasma membrane H(+)-ATPase isoform 2 (AHA2) consists of an aspartate residue serving as key proton donor/acceptor (Asp-684) and an arginine residue controlling the pKa of the aspartate.	Aspartic Acid	132-141	H[+]-ATPase 2	Arabidopsis thaliana	111-115
23420846-1	2013	The minimal proton pumping machinery of the Arabidopsis thaliana P-type plasma membrane H(+)-ATPase isoform 2 (AHA2) consists of an aspartate residue serving as key proton donor/acceptor (Asp-684) and an arginine residue controlling the pKa of the aspartate.	Aspartic Acid	188-191	H[+]-ATPase 2	Arabidopsis thaliana	111-115
23420846-1	2013	The minimal proton pumping machinery of the Arabidopsis thaliana P-type plasma membrane H(+)-ATPase isoform 2 (AHA2) consists of an aspartate residue serving as key proton donor/acceptor (Asp-684) and an arginine residue controlling the pKa of the aspartate.	Aspartic Acid	248-257	H[+]-ATPase 2	Arabidopsis thaliana	111-115
23592913-6	2013	Sequencing of the candidate genes revealed a heterozygous c. 139G&gt;C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H).	Aspartic Acid	214-227	gap junction protein alpha 8	Homo sapiens	108-119
23592913-6	2013	Sequencing of the candidate genes revealed a heterozygous c. 139G&gt;C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H).	Aspartic Acid	214-227	gap junction protein alpha 8	Homo sapiens	126-155
23592913-6	2013	Sequencing of the candidate genes revealed a heterozygous c. 139G&gt;C change in the coding sequence of the connexin 50 gene (gap junction protein, alpha 8 [GJA8]), which results in the substitution of a wild-type aspartic acid with a histidine (D47H).	Aspartic Acid	214-227	gap junction protein alpha 8	Homo sapiens	157-161
23473379-2	2013	GE was highly specific and hydrolyzed peptide bonds in beta-casein predominantly on the carboxy terminal of Glu and Asp.	Aspartic Acid	116-119	casein beta	Bos taurus	55-66
23625227-12	2013	We found that MICB*008 which contains methionine and asparagine at the amino acid positions 98 and 113, respectively, in the alpha 2 domain showed decreased binding activities to UL16 when compared to MICB*003, 004, and MICB*00502 containing isoleucine and aspartic acid, respectively.	Aspartic Acid	257-270	MHC class I polypeptide-related sequence B	Homo sapiens	14-18
23465612-0	2013	Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.	Aspartic Acid	103-113	beta-secretase 1	Homo sapiens	52-58
23393150-6	2013	Analysis of the resulting LPS conferred by these mutant His6-FepE proteins showed that amino acid substitutions of leucine 168 (L168) and aspartic acid 268 (D268) resulted in LPS with consistently shortened Oag chain lengths of &lt;80 Oag RUs.	Aspartic Acid	138-151	ferric enterobactin transport protein	Shigella flexneri	61-65
24052926-0	2013	New method to visualize neurons with DAT in slices of rat VTA using fluorescent substrate for DAT, ASP+ The ventral tegmental area (VTA), and in particular dopamine (DA) neurons in this region of midbrain, has been shown to play an important role in motivation (goal-directed behavior), reward, and drug addiction.	Aspartic Acid	99-103	solute carrier family 6 member 3	Rattus norvegicus	37-40
24052926-2	2013	In this study, we used a known neuronal dopamine transporter (DAT) fluorescent substrate [4-(4- (dimethylamino) styryl)-N-methylpyridinium iodide] (ASP+) to visualize DAT-containing cell bodies of DA neurons in VTA region in rat brain slices.	Aspartic Acid	148-152	solute carrier family 6 member 3	Rattus norvegicus	40-60
24052926-2	2013	In this study, we used a known neuronal dopamine transporter (DAT) fluorescent substrate [4-(4- (dimethylamino) styryl)-N-methylpyridinium iodide] (ASP+) to visualize DAT-containing cell bodies of DA neurons in VTA region in rat brain slices.	Aspartic Acid	148-152	solute carrier family 6 member 3	Rattus norvegicus	62-65
24052926-2	2013	In this study, we used a known neuronal dopamine transporter (DAT) fluorescent substrate [4-(4- (dimethylamino) styryl)-N-methylpyridinium iodide] (ASP+) to visualize DAT-containing cell bodies of DA neurons in VTA region in rat brain slices.	Aspartic Acid	148-152	solute carrier family 6 member 3	Rattus norvegicus	167-170
24052926-7	2013	Thus, uptake of fluorescent monoamine analog ASP+ by DAT can be an additional criterion for identification of DAT-containing neurons in slices.	Aspartic Acid	45-49	solute carrier family 6 member 3	Rattus norvegicus	53-56
24052926-7	2013	Thus, uptake of fluorescent monoamine analog ASP+ by DAT can be an additional criterion for identification of DAT-containing neurons in slices.	Aspartic Acid	45-49	solute carrier family 6 member 3	Rattus norvegicus	110-113
23339867-6	2013	More interestingly, cells that carry a CLN3 allele encoding aspartic acid substitutions at the sites of Pho85 phosphorylation maintain high levels of Cln3 independently of Pho85 activity.	Aspartic Acid	60-73	cyclin CLN3	Saccharomyces cerevisiae S288C	39-43
23506861-8	2013	Some years ago, a high resolution structure of an archaeal homologue of the SLC1 family was determined, followed by the elucidation of its structure in the presence of the substrate aspartate and the inhibitor d,l-threo-benzyloxy aspartate (d,l-TBOA).	Aspartic Acid	182-191	melanin concentrating hormone receptor 1	Homo sapiens	76-80
23339867-6	2013	More interestingly, cells that carry a CLN3 allele encoding aspartic acid substitutions at the sites of Pho85 phosphorylation maintain high levels of Cln3 independently of Pho85 activity.	Aspartic Acid	60-73	cyclin-dependent serine/threonine-protein kinase PHO85	Saccharomyces cerevisiae S288C	104-109
23339867-6	2013	More interestingly, cells that carry a CLN3 allele encoding aspartic acid substitutions at the sites of Pho85 phosphorylation maintain high levels of Cln3 independently of Pho85 activity.	Aspartic Acid	60-73	cyclin CLN3	Saccharomyces cerevisiae S288C	150-154
23240581-3	2013	In the present study, we demonstrate that the adaptor LAT is also subject to a proteolytic cleavage in mature T-lymphocytes and thymocytes in response to Fas engagement, and also on TCR stimulation, and we identify three aspartic acid residues at which LAT is cleaved.	Aspartic Acid	221-234	linker for activation of T cells	Homo sapiens	54-57
23016589-1	2013	Lamprey gonadotropin-releasing hormone-III (lGnRH-III; Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2), a native isoform of human GnRH (GnRH-I), was initially isolated from the brain of the sea lamprey (Petromyzon marinus).	Aspartic Acid	75-78	gonadotropin releasing hormone 1	Homo sapiens	45-51
23376080-7	2013	In conclusion, we postulate that Asp378 and Asp379 in the C-terminal part of Cx43 are essential for loop/tail interactions in Cx43 hemichannels, while Pro375 and Pro377 may help to properly coordinate the critical Asp residues.	Aspartic Acid	33-36	gap junction protein alpha 1	Homo sapiens	77-81
23376080-7	2013	In conclusion, we postulate that Asp378 and Asp379 in the C-terminal part of Cx43 are essential for loop/tail interactions in Cx43 hemichannels, while Pro375 and Pro377 may help to properly coordinate the critical Asp residues.	Aspartic Acid	33-36	gap junction protein alpha 1	Homo sapiens	126-130
23386619-8	2013	Asp-394 on TM8 and Arg-276 on HP1 emerge as key residues that promote the reorientation and diffusion of substrate toward the cell interior.	Aspartic Acid	0-3	tetraspanin 16	Homo sapiens	11-14
23386619-8	2013	Asp-394 on TM8 and Arg-276 on HP1 emerge as key residues that promote the reorientation and diffusion of substrate toward the cell interior.	Aspartic Acid	0-3	chromobox 5	Homo sapiens	30-33
23447526-6	2013	It is demonstrated here that Nin88, lacking both Asp-239 and Trp-47 homologs, has no invertase activity.	Aspartic Acid	49-52	beta-fructofuranosidase, insoluble isoenzyme 1-like	Nicotiana tabacum	29-34
23393130-6	2013	A382T and T459R altered the substrate selectivity of ASCT1 to allow the transport of acidic amino acids, particularly l-aspartate.	Aspartic Acid	118-129	solute carrier family 1 member 4	Homo sapiens	53-58
23393130-7	2013	The combination of A382T and T459R within ASCT1 generates a transporter with a similar profile to that of GltPh, with preference for l-aspartate over l-glutamate.	Aspartic Acid	133-144	solute carrier family 1 member 4	Homo sapiens	42-47
23240581-3	2013	In the present study, we demonstrate that the adaptor LAT is also subject to a proteolytic cleavage in mature T-lymphocytes and thymocytes in response to Fas engagement, and also on TCR stimulation, and we identify three aspartic acid residues at which LAT is cleaved.	Aspartic Acid	221-234	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	182-185
23240581-3	2013	In the present study, we demonstrate that the adaptor LAT is also subject to a proteolytic cleavage in mature T-lymphocytes and thymocytes in response to Fas engagement, and also on TCR stimulation, and we identify three aspartic acid residues at which LAT is cleaved.	Aspartic Acid	221-234	linker for activation of T cells	Homo sapiens	253-256
23240581-4	2013	Interestingly, these aspartic acid residues are located in proximity to several functionally important tyrosine residues of LAT, raising the possibility that their phosphorylation could modulate LAT cleavage.	Aspartic Acid	21-34	linker for activation of T cells	Homo sapiens	124-127
23240581-4	2013	Interestingly, these aspartic acid residues are located in proximity to several functionally important tyrosine residues of LAT, raising the possibility that their phosphorylation could modulate LAT cleavage.	Aspartic Acid	21-34	linker for activation of T cells	Homo sapiens	195-198
23221336-2	2013	A vesicular release mechanism for l-aspartate has been difficult to prove, as no vesicular l-aspartate transporter was identified until it was found that sialin could transport l-aspartate and l-glutamate when reconstituted into liposomes.	Aspartic Acid	34-45	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	154-160
23280928-10	2013	A statistical study revealed close correlation between ASP, body mass index, and highly sensitive C-reactive protein.	Aspartic Acid	55-58	C-reactive protein	Homo sapiens	98-116
23280575-3	2013	To gain mechanistic insights, we used model hexapeptides, YADXFK, YADDXK, and DIDDDM, as surrogates for the hotspots in a Fab protein (YADDFK and DIDDDM), to characterize the rate-pH profile of Asp isomerization.	Aspartic Acid	194-197	FA complementation group B	Homo sapiens	122-125
23108585-12	2013	Our data provide novel insights into the mechanisms of alpha-synuclein-induced microglial and astroglial activation which may have an impact on understanding the pathogenesis of ASP.	Aspartic Acid	178-181	synuclein, alpha	Mus musculus	55-70
22961935-3	2013	Herein, we prepared RGDS peptide photocaged either on the Arg-Gly backbone amide nitrogen atom (R[-]GDS) or Asp side chain carboxyl (RG[D]S).	Aspartic Acid	108-111	ral guanine nucleotide dissociation stimulator	Homo sapiens	20-24
22991293-3	2013	Inactivating mutations in PHEX lead to distal renal effects (implying accumulation of a secreted, circulating phosphaturic factor) and accumulation in bone and teeth of mineralization-inhibiting, acidic serine- and aspartate-rich motif (ASARM)-containing peptides, which are proteolytically derived from the mineral-binding matrix proteins of the SIBLING family (small, integrin-binding ligand N-linked glycoproteins).	Aspartic Acid	215-224	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	26-30
23345589-4	2013	In this study, we have demonstrated that, in apoptotic cells, the myosin-binding domain of myosin phosphatase targeting subunit 1 (MYPT1) is cleaved by caspase-3 at Asp-884, and the cleaved MYPT1 is strongly phosphorylated at Thr-696 and Thr-853, phosphorylation of which is known to inhibit myosin II binding.	Aspartic Acid	165-168	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	91-129
23385093-1	2013	A common modification of human long-lived proteins is spontaneous isomerisation of aspartate residues, and its biological importance can be inferred from the ubiquitous presence of protein isoaspartate methyl transferase (PIMT), that repairs this damage.	Aspartic Acid	83-92	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	181-220
23385093-1	2013	A common modification of human long-lived proteins is spontaneous isomerisation of aspartate residues, and its biological importance can be inferred from the ubiquitous presence of protein isoaspartate methyl transferase (PIMT), that repairs this damage.	Aspartic Acid	83-92	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	222-226
23385093-9	2013	If PIMT is present, L-isoAsp may be reverted to L-Asp, however there appears to be no prospect of reversing D-isoAsp formation in aged proteins.	Aspartic Acid	48-53	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	3-7
23345589-4	2013	In this study, we have demonstrated that, in apoptotic cells, the myosin-binding domain of myosin phosphatase targeting subunit 1 (MYPT1) is cleaved by caspase-3 at Asp-884, and the cleaved MYPT1 is strongly phosphorylated at Thr-696 and Thr-853, phosphorylation of which is known to inhibit myosin II binding.	Aspartic Acid	165-168	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	131-136
23345589-4	2013	In this study, we have demonstrated that, in apoptotic cells, the myosin-binding domain of myosin phosphatase targeting subunit 1 (MYPT1) is cleaved by caspase-3 at Asp-884, and the cleaved MYPT1 is strongly phosphorylated at Thr-696 and Thr-853, phosphorylation of which is known to inhibit myosin II binding.	Aspartic Acid	165-168	caspase 3	Homo sapiens	152-161
23274258-0	2013	Growth and characterization of KDP crystals doped with L-aspartic acid.	Aspartic Acid	55-70	WNK lysine deficient protein kinase 1	Homo sapiens	31-34
23274258-1	2013	Potassium Dihydrogen Phosphate (KDP) doped with L-aspartic acid has been grown by solvent slow evaporation technique from a mixture of aqueous solution of KDP and 0.7% of L-aspartic acid at room temperature.	Aspartic Acid	48-63	WNK lysine deficient protein kinase 1	Homo sapiens	32-35
23274258-1	2013	Potassium Dihydrogen Phosphate (KDP) doped with L-aspartic acid has been grown by solvent slow evaporation technique from a mixture of aqueous solution of KDP and 0.7% of L-aspartic acid at room temperature.	Aspartic Acid	48-63	WNK lysine deficient protein kinase 1	Homo sapiens	155-158
23274258-1	2013	Potassium Dihydrogen Phosphate (KDP) doped with L-aspartic acid has been grown by solvent slow evaporation technique from a mixture of aqueous solution of KDP and 0.7% of L-aspartic acid at room temperature.	Aspartic Acid	171-186	WNK lysine deficient protein kinase 1	Homo sapiens	32-35
23274258-4	2013	The Nonlinear optical property (SHG) of L-aspartic acid doped KDP has been confirmed.	Aspartic Acid	40-55	WNK lysine deficient protein kinase 1	Homo sapiens	62-65
23376504-0	2013	Aspartate buffer and divalent metal ions affect oxytocin in aqueous solution and protect it from degradation.	Aspartic Acid	0-9	oxytocin/neurophysin I prepropeptide	Homo sapiens	48-56
23376504-3	2013	In a previous study, we have found that the stability of oxytocin in aspartate buffered formulation is improved by the addition of divalent metal ions (unpublished results).	Aspartic Acid	69-78	oxytocin/neurophysin I prepropeptide	Homo sapiens	57-65
23376504-5	2013	In addition, it was found that stabilization correlated well with the ability of the divalent metal ions to interact with oxytocin in aspartate buffer.	Aspartic Acid	134-143	oxytocin/neurophysin I prepropeptide	Homo sapiens	122-130
23376504-7	2013	These results lead to the hypothesis that in aspartate buffer, Zn(2+) changes the conformation of oxytocin in such a way that the Cys(1,6) disulfide bridge is shielded from its environment thereby suppressing intermolecular reactions involving this region of the molecule.	Aspartic Acid	45-54	oxytocin/neurophysin I prepropeptide	Homo sapiens	98-106
23376504-8	2013	To verify this hypothesis, we investigate here the conformation of oxytocin in aspartate buffer in the presence of Mg(2+) or Zn(2+), using 2D NOESY, TOCSY, (1)H-(13)C HSQC and (1)H-(15)N HSQC NMR spectroscopy.	Aspartic Acid	79-88	oxytocin/neurophysin I prepropeptide	Homo sapiens	67-75
23376504-10	2013	(1)H-(13)C and (1)H-(15)N HSQC spectra showed that aspartate buffer alone induces minor changes in oxytocin in D2O, with the largest chemical shift changes observed for Cys(1).	Aspartic Acid	51-60	oxytocin/neurophysin I prepropeptide	Homo sapiens	99-107
23421681-3	2013	The longitudinal axis of the substrates is similarly oriented with these, forming an ionic interaction between the ammonium group and a highly conserved aspartate, Asp98 (serotonin transporter, hSERT), Asp79 (dopamine transporter, hDAT), and Asp75 (norepinephrine transporter, hNET).	Aspartic Acid	153-162	solute carrier family 6 member 3	Homo sapiens	231-235
23327623-3	2013	In almost all organisms, protein L-isoaspartate O-methyltransferase (PIMT, EC2.1.1.77) recognizes and initiates the conversion of isoAsp back to aspartic acid.	Aspartic Acid	145-158	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	69-73
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Aspartic Acid	128-131	nitric oxide synthase 1	Homo sapiens	30-34
23421681-3	2013	The longitudinal axis of the substrates is similarly oriented with these, forming an ionic interaction between the ammonium group and a highly conserved aspartate, Asp98 (serotonin transporter, hSERT), Asp79 (dopamine transporter, hDAT), and Asp75 (norepinephrine transporter, hNET).	Aspartic Acid	153-162	solute carrier family 6 member 2	Homo sapiens	249-275
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Aspartic Acid	128-131	nitric oxide synthase 3	Homo sapiens	39-43
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Aspartic Acid	128-131	nitric oxide synthase 1	Homo sapiens	135-139
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Aspartic Acid	128-131	nitric oxide synthase 3	Homo sapiens	151-155
23421681-3	2013	The longitudinal axis of the substrates is similarly oriented with these, forming an ionic interaction between the ammonium group and a highly conserved aspartate, Asp98 (serotonin transporter, hSERT), Asp79 (dopamine transporter, hDAT), and Asp75 (norepinephrine transporter, hNET).	Aspartic Acid	153-162	solute carrier family 6 member 2	Homo sapiens	277-281
23030042-12	2013	Initial crystal structures of nNOS and eNOS bound to selective dipeptide inhibitors showed that a single amino acid difference (Asp in nNOS and Asn in eNOS) results in much tighter binding to nNOS.	Aspartic Acid	128-131	nitric oxide synthase 1	Homo sapiens	135-139
23255614-9	2013	N-acetyl aspartate weakly interacted with OAT1, but aspartate did not.	Aspartic Acid	9-18	solute carrier family 22 member 6	Homo sapiens	42-46
22972628-1	2013	BACKGROUND: The authors conducted a systematic review and meta-analysis to examine whether patients who had metastatic colorectal cancer (mCRC) with the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) p.G13D mutation (an amino acid substitution at position 13 in KRAS from a glycine to an aspartic acid) and received cetuximab treatment had better clinical outcomes than patients who had mCRC tumors with KRAS codon 12 mutations.	Aspartic Acid	301-314	KRAS proto-oncogene, GTPase	Rattus norvegicus	207-211
23241029-4	2013	Using a fluorescence assay of ASP(+) uptake in cells stably expressing MATE1, over 900 prescription drugs were screened and 84 potential MATE1 inhibitors were found.	Aspartic Acid	30-36	solute carrier family 47 member 1	Homo sapiens	71-76
23288838-4	2013	We recently showed that a conserved aspartate residue of GAT-1, Asp-451, whose LeuT equivalent participates in its thin extracellular gate, is functionally irreplaceable in GAT-1.	Aspartic Acid	36-45	solute carrier family 6 member 1	Homo sapiens	57-62
23288838-4	2013	We recently showed that a conserved aspartate residue of GAT-1, Asp-451, whose LeuT equivalent participates in its thin extracellular gate, is functionally irreplaceable in GAT-1.	Aspartic Acid	36-45	solute carrier family 6 member 1	Homo sapiens	173-178
23288838-4	2013	We recently showed that a conserved aspartate residue of GAT-1, Asp-451, whose LeuT equivalent participates in its thin extracellular gate, is functionally irreplaceable in GAT-1.	Aspartic Acid	64-67	solute carrier family 6 member 1	Homo sapiens	57-62
23288838-4	2013	We recently showed that a conserved aspartate residue of GAT-1, Asp-451, whose LeuT equivalent participates in its thin extracellular gate, is functionally irreplaceable in GAT-1.	Aspartic Acid	64-67	solute carrier family 6 member 1	Homo sapiens	173-178
23241029-4	2013	Using a fluorescence assay of ASP(+) uptake in cells stably expressing MATE1, over 900 prescription drugs were screened and 84 potential MATE1 inhibitors were found.	Aspartic Acid	30-36	solute carrier family 47 member 1	Homo sapiens	137-142
23313943-0	2013	Salt bridge in the conserved His-Asp cluster in Gloeobacter rhodopsin contributes to trimer formation.	Aspartic Acid	33-36	rhodopsin	Homo sapiens	60-69
23313943-1	2013	Gloeobacter rhodopsin (GR) is a eubacterial proton pump having a highly conserved histidine near the retinal Schiff base counter-ion, aspartate.	Aspartic Acid	134-143	rhodopsin	Homo sapiens	12-21
23318500-2	2013	Linked by a specific disulfide bond (Cys(100)-Cys(650)), the N-terminal (N(t)) and the EC3 loop C-terminal (C(t)) segments of angiotensin II (AngII) receptor 1 (AT(1)R) have been identified to form an extracellular site for binding the agonist N(t) segment (Asp(1) and Arg(2) residues).	Aspartic Acid	258-261	angiotensin II receptor type 1	Homo sapiens	126-167
23318500-4	2013	By homology, a similar site might be considered for DABK binding to B(1)R since this receptor contains the same structural elements for composing the site in AT(1)R, namely the disulfide bond and the EC3 loop Asp(712) residue.	Aspartic Acid	209-212	angiotensin II receptor type 1	Homo sapiens	158-164
23318500-7	2013	Confirming this preliminary supposition, mutation of residues located at the B(1)R extracellular site as EC3 loop Asp(712) and Cys(100) caused the same modifications in biological assays observed in AT(1)R submitted to homologous mutations, such as significant weakening of agonist binding and reduction of post-receptor-activation processes.	Aspartic Acid	114-117	angiotensin II receptor type 1	Homo sapiens	199-205
23795239-3	2013	One Asp residue, D862 was identified as a critical participant in binding to the PI3Kbeta-selective inhibitors distinguishing this class from other reported PI3Kbeta-selective inhibitors.	Aspartic Acid	4-7	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	81-89
23795239-3	2013	One Asp residue, D862 was identified as a critical participant in binding to the PI3Kbeta-selective inhibitors distinguishing this class from other reported PI3Kbeta-selective inhibitors.	Aspartic Acid	4-7	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	157-165
23284103-8	2013	Indeed, murine BMP15 activity was restored when specific residues through this region (Pro(329)/Tyr(330)) were replaced with the corresponding residues (Arg(329)/Asp(330)) from human BMP15.	Aspartic Acid	162-165	bone morphogenetic protein 15	Mus musculus	15-20
22718265-1	2013	Animal aspartate decarboxylase (ADC), glutamate decarboxylase (GDC) and cysteine sulfinic acid decarboxylase (CSADC) catalyze the decarboxylation of aspartate, glutamate and cysteine sulfinic acid to beta-alanine, gamma-aminobutyric acid and hypotaurine, respectively.	Aspartic Acid	7-16	glutamate-ammonia ligase	Homo sapiens	63-66
22718265-1	2013	Animal aspartate decarboxylase (ADC), glutamate decarboxylase (GDC) and cysteine sulfinic acid decarboxylase (CSADC) catalyze the decarboxylation of aspartate, glutamate and cysteine sulfinic acid to beta-alanine, gamma-aminobutyric acid and hypotaurine, respectively.	Aspartic Acid	7-16	cysteine sulfinic acid decarboxylase	Homo sapiens	110-115
23140583-13	2013	The binding site in TRPV6 was an aspartic acid at amino acid residue 716, and that binding site in Numb1 was arginine at amino acid residue 434.	Aspartic Acid	33-46	transient receptor potential cation channel subfamily V member 6	Homo sapiens	20-25
23955828-5	2013	Conserved amino acid residues involved in recognition of the 5" end of the small RNA guide strand and of the conserved (aspartate, aspartate and histidine [DDH]) motif present in their PIWI domains suggest that these four Argonaute family members may have conserved slicer activities.	Aspartic Acid	120-129	P-element induced wimpy testis	Drosophila melanogaster	185-189
23150525-3	2013	We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.	Aspartic Acid	164-167	caspase 3	Homo sapiens	118-134
23150525-3	2013	We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.	Aspartic Acid	164-167	N-myristoyltransferase 1	Homo sapiens	156-160
23150525-3	2013	We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.	Aspartic Acid	164-167	N-myristoyltransferase 2	Homo sapiens	196-200
23150525-3	2013	We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.	Aspartic Acid	164-167	caspase 3	Homo sapiens	118-127
23150525-3	2013	We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.	Aspartic Acid	224-227	N-myristoyltransferase 1	Homo sapiens	37-75
23150525-3	2013	We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.	Aspartic Acid	224-227	caspase 3	Homo sapiens	118-134
23150525-3	2013	We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.	Aspartic Acid	224-227	N-myristoyltransferase 1	Homo sapiens	156-160
23150525-3	2013	We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.	Aspartic Acid	224-227	caspase 3	Homo sapiens	118-127
23955828-5	2013	Conserved amino acid residues involved in recognition of the 5" end of the small RNA guide strand and of the conserved (aspartate, aspartate and histidine [DDH]) motif present in their PIWI domains suggest that these four Argonaute family members may have conserved slicer activities.	Aspartic Acid	131-140	P-element induced wimpy testis	Drosophila melanogaster	185-189
23216354-0	2013	AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway.	Aspartic Acid	12-21	aggrecan	Mus musculus	0-4
23283728-2	2013	Proteins that have both these functional groups in abundance are no exception, and presence of amino acids such as asparagine, glutamines, aspartic acids, and glutamic acids aid in formation of such intermediates.	Aspartic Acid	139-153	activation induced cytidine deaminase	Homo sapiens	174-177
22961875-8	2013	The Asp, Glu, and Ser residues in MIP3 play important roles for the affinity of calcium in HA bone mineral.	Aspartic Acid	4-7	C-C motif chemokine ligand 23	Homo sapiens	34-38
23216354-1	2013	The mitochondrial transporter of aspartate-glutamate Aralar/AGC1 is a regulatory component of the malate-aspartate shuttle.	Aspartic Acid	33-42	solute carrier family 25 member 12	Homo sapiens	53-59
23220277-5	2013	In order to select a reasonable binding mode, several other ligands including agonists and antagonists are docked into H4R, and the results reveal that all ligands share one preferable binding mode: the protonated NH tightly interacts with Asp(3.32) and the imidazole NH interacts with Glu(5.46).	Aspartic Acid	240-243	histamine receptor H4	Homo sapiens	119-122
23216354-1	2013	The mitochondrial transporter of aspartate-glutamate Aralar/AGC1 is a regulatory component of the malate-aspartate shuttle.	Aspartic Acid	33-42	aggrecan	Mus musculus	60-64
23216354-1	2013	The mitochondrial transporter of aspartate-glutamate Aralar/AGC1 is a regulatory component of the malate-aspartate shuttle.	Aspartic Acid	105-114	solute carrier family 25 member 12	Homo sapiens	53-59
23216354-1	2013	The mitochondrial transporter of aspartate-glutamate Aralar/AGC1 is a regulatory component of the malate-aspartate shuttle.	Aspartic Acid	105-114	aggrecan	Mus musculus	60-64
23408788-5	2013	Ser(780) in the Kex2p C-tail is crucial for binding: an Ala substitution blocks but an Asp substitution permits binding.	Aspartic Acid	87-90	kexin KEX2	Saccharomyces cerevisiae S288C	16-21
23065292-5	2013	Meta-analysis of six studies showed a significant association between the Gly/Gly+Gly/Asp genotype of the TLR4 Asp299Gly polymorphism and vasculitis and GCA (Odds ratio [OR] = 1.368, 95 % confidence interval [CI] = 1.300-1.815, p = 0.030; OR = 1.523, 95 % CI = 1.099-2.112, p = 0.012).	Aspartic Acid	86-89	toll like receptor 4	Homo sapiens	106-110
23065292-6	2013	Under a random effects model, the adjusted ORs calculated using the trim and fill technique revealed an association between the Gly/Gly+Gly/Asp genotype of the TLR4 Asp299Gly polymorphism and vasculitis (OR = 1.544, 95 % CI = 1.091-2.185, p &lt; 0.05).	Aspartic Acid	140-143	toll like receptor 4	Homo sapiens	160-164
23408788-6	2013	Biochemical assays using purified Gga2p VHS-GGA and TOM1 (GAT) and glutathione S-transferase-Kex2p C-tail fusions show that Gga2p binds directly to the Kex2p C-tail, with relative affinities Asp(780) &gt; Ser(780) &gt; Ala(780).	Aspartic Acid	191-194	phosphatidylinositol 4-phosphate-binding protein	Saccharomyces cerevisiae S288C	124-129
23408788-6	2013	Biochemical assays using purified Gga2p VHS-GGA and TOM1 (GAT) and glutathione S-transferase-Kex2p C-tail fusions show that Gga2p binds directly to the Kex2p C-tail, with relative affinities Asp(780) &gt; Ser(780) &gt; Ala(780).	Aspartic Acid	191-194	kexin KEX2	Saccharomyces cerevisiae S288C	152-157
23668019-14	2013	ASP could significantly decrease the percentage of SA-beta-Gal positive cells, the ratio of G1 stages and the production of ROS in HSCs, and downregulate the expression of p16 in mRNA level in HSCs contrast to aging group without ASP treatment.	Aspartic Acid	230-233	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	172-175
23212920-0	2013	Rapid nucleotide exchange renders Asp-11 mutant actins resistant to depolymerizing activity of cofilin, leading to dominant toxicity in vivo.	Aspartic Acid	34-37	cofilin 1	Homo sapiens	95-102
23668019-14	2013	ASP could significantly decrease the percentage of SA-beta-Gal positive cells, the ratio of G1 stages and the production of ROS in HSCs, and downregulate the expression of p16 in mRNA level in HSCs contrast to aging group without ASP treatment.	Aspartic Acid	0-3	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	172-175
23195954-2	2013	We demonstrate unknown facets of calnuc, which is a serine protease in which Ser-378 of GXSXG motif, Asp-328 of DTG motif, and His-339 form the "catalytic triad," locating the enzyme active site in the C-terminal region.	Aspartic Acid	101-104	nucleobindin 1	Homo sapiens	33-39
23668019-14	2013	ASP could significantly decrease the percentage of SA-beta-Gal positive cells, the ratio of G1 stages and the production of ROS in HSCs, and downregulate the expression of p16 in mRNA level in HSCs contrast to aging group without ASP treatment.	Aspartic Acid	0-3	SH3-domain binding protein 5 (BTK-associated)	Mus musculus	51-58
23223357-6	2013	A similar effect was seen for the uptake of the hOCT1 substrates TEA(+) and ASP(+).	Aspartic Acid	76-79	solute carrier family 22 member 1	Homo sapiens	48-53
22897592-3	2013	The main cause of Akt inhibition is considered to be the strong hydrogen bond between N-H and Thr-291, and hydrophobic interactions at Glu-234, and Asp-292 in the vicinity, which is usually occupied by the ribose of ATP, and interaction with residue Phe-161, thus leading to a significant conformational change in that particular portion of the protein.	Aspartic Acid	148-151	AKT serine/threonine kinase 1	Homo sapiens	18-21
23195954-2	2013	We demonstrate unknown facets of calnuc, which is a serine protease in which Ser-378 of GXSXG motif, Asp-328 of DTG motif, and His-339 form the "catalytic triad," locating the enzyme active site in the C-terminal region.	Aspartic Acid	101-104	coagulation factor II, thrombin	Homo sapiens	52-67
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Aspartic Acid	146-149	tachykinin precursor 1	Homo sapiens	42-54
23166321-4	2013	Analysis of this model suggested that Gln-97 and Asp-98 were required for interaction with VGVAPG because they contribute to the definition of a pocket thought to represent the elastin binding site of EBP.	Aspartic Acid	49-52	elastin	Homo sapiens	177-184
23166321-4	2013	Analysis of this model suggested that Gln-97 and Asp-98 were required for interaction with VGVAPG because they contribute to the definition of a pocket thought to represent the elastin binding site of EBP.	Aspartic Acid	49-52	EBP cholestenol delta-isomerase	Homo sapiens	201-204
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Aspartic Acid	146-149	tachykinin precursor 1	Homo sapiens	56-74
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Aspartic Acid	146-149	tachykinin precursor 1	Homo sapiens	207-221
22940581-5	2013	Here we determined kinetic and structural properties of POP with mutations in loop A, loop B, and in two additional flexible loops (the catalytic His loop, propeller Asp/Glu loop).	Aspartic Acid	166-169	prolyl endopeptidase	Homo sapiens	56-59
23248278-5	2013	S639A mutants of both subfragment 1 and full-length myosin had actin-activated MgATPase that was not inhibited by phosphorylation of the serines in the nonhelical tailpiece or their mutation to glutamic acid or aspartic acid.	Aspartic Acid	211-224	myosin heavy chain 14	Homo sapiens	52-58
23291379-9	2013	In silico modeling suggested that ethanol alters the dynamics for assembling Abeta by disrupting a critical salt bridge between residues Asp 23 and Lys 28, required for amyloid dimerization.	Aspartic Acid	137-140	amyloid beta precursor protein	Homo sapiens	77-82
23022039-2	2013	More than one third of the mammalian PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low molecular mass, Ca(2+)-requiring enzymes with a His-Asp catalytic dyad.	Aspartic Acid	174-177	phospholipase A2 group IB	Homo sapiens	37-43
23730923-1	2013	PRIMARY OBJECTIVE: The mechanism underlying interleukin-6 (IL-6) prevention of N-methyl-D-aspartate (NMDA)-induced neuronal Ca(2+) overload was explored at the profile of Ca(2+) channel receptors, including NMDA, inositol 1,4,5-trisphosphate and ryanodine receptors (NMDAR, IP3R and RyR, respectively).	Aspartic Acid	90-99	interleukin 6	Rattus norvegicus	44-57
23022039-2	2013	More than one third of the mammalian PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low molecular mass, Ca(2+)-requiring enzymes with a His-Asp catalytic dyad.	Aspartic Acid	174-177	phospholipase A2 group IB	Homo sapiens	75-81
23022039-2	2013	More than one third of the mammalian PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low molecular mass, Ca(2+)-requiring enzymes with a His-Asp catalytic dyad.	Aspartic Acid	174-177	phospholipase A2 group IIA	Homo sapiens	83-90
23730923-1	2013	PRIMARY OBJECTIVE: The mechanism underlying interleukin-6 (IL-6) prevention of N-methyl-D-aspartate (NMDA)-induced neuronal Ca(2+) overload was explored at the profile of Ca(2+) channel receptors, including NMDA, inositol 1,4,5-trisphosphate and ryanodine receptors (NMDAR, IP3R and RyR, respectively).	Aspartic Acid	90-99	interleukin 6	Rattus norvegicus	59-63
24124363-3	2013	In this study, we explore the preparation and characterization of gadolinium (Gd)-loaded poly (lactic-co-glycolic acid) (PLGA) particles surface modified with the Arg-Gly-Asp-Ser (RGDS) peptide for the detection of thrombus.	Aspartic Acid	171-174	ral guanine nucleotide dissociation stimulator	Homo sapiens	180-184
23484211-2	2013	Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.	Aspartic Acid	77-80	interleukin 2	Homo sapiens	191-195
23484211-2	2013	Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.	Aspartic Acid	77-80	matrix metallopeptidase 2	Homo sapiens	197-201
23484211-2	2013	Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.	Aspartic Acid	77-80	translocation associated membrane protein 1	Homo sapiens	207-212
24372240-7	2013	The protein-protein docking showed that the aminoacid residues of NS3 which were interacting with NRBP were found to be Ala 325, Asp 324, Phe 326, Asp 335, Glu 336, Glu 328, Asp 485, Gln 478, Arg 459, Gly 446 and Leu 480.	Aspartic Acid	129-132	KRAS proto-oncogene, GTPase	Homo sapiens	66-69
24372240-7	2013	The protein-protein docking showed that the aminoacid residues of NS3 which were interacting with NRBP were found to be Ala 325, Asp 324, Phe 326, Asp 335, Glu 336, Glu 328, Asp 485, Gln 478, Arg 459, Gly 446 and Leu 480.	Aspartic Acid	129-132	nuclear receptor binding protein 1	Homo sapiens	98-102
24372240-7	2013	The protein-protein docking showed that the aminoacid residues of NS3 which were interacting with NRBP were found to be Ala 325, Asp 324, Phe 326, Asp 335, Glu 336, Glu 328, Asp 485, Gln 478, Arg 459, Gly 446 and Leu 480.	Aspartic Acid	147-150	KRAS proto-oncogene, GTPase	Homo sapiens	66-69
24372240-7	2013	The protein-protein docking showed that the aminoacid residues of NS3 which were interacting with NRBP were found to be Ala 325, Asp 324, Phe 326, Asp 335, Glu 336, Glu 328, Asp 485, Gln 478, Arg 459, Gly 446 and Leu 480.	Aspartic Acid	147-150	nuclear receptor binding protein 1	Homo sapiens	98-102
23484211-2	2013	Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.	Aspartic Acid	77-80	CD5 molecule	Homo sapiens	186-189
24605586-3	2013	Two single nucleotide polymorphisms--MMP9 (C(-1562) --&gt; T) and NOS3 (Glu298 --&gt; Asp)--rs3918242 and rs1799983--were shown to represent the main independent effects with the highest predictive potential (77.1% as indicated by binary logistic regression and 74.6% testing accuracy shown by Multifactorial Dimensionality Reduction).	Aspartic Acid	86-89	nitric oxide synthase 3	Homo sapiens	66-70
24605586-4	2013	MMP9 (C(-1562 --&gt; T) and NOS3 (Glu298 --&gt; Asp) potentially may be used to create predictive algorithm for determination of predisposition to arterial hypertension in children.	Aspartic Acid	48-51	nitric oxide synthase 3	Homo sapiens	28-32
23090962-5	2013	The predicted ORF4 product is closely related to isopentenyl isomerase (IDI) enzymes, whereas the predicted product of the adjacent ORF3 exhibits an aspartate-rich region that is common among trans-isoprenyl phosphate synthases.	Aspartic Acid	149-158	hypothetical protein	Escherichia coli	132-136
24149797-3	2013	We find that PglB can glycosylate not only asparagine but also glutamine, homoserine and the hydroxamate Asp(NHOH), although at much lower rates.	Aspartic Acid	105-108	epiphycan	Homo sapiens	13-17
23554862-8	2013	Sequence analyses revealed that only one amino acid exchange in the H-protein at position 540 Asp Gly (D540G) was required for functional adaptation to human CD150.	Aspartic Acid	94-97	signaling lymphocytic activation molecule family member 1	Homo sapiens	158-163
23443546-3	2013	During evolution, C4 phosphoenolpyruvate carboxylase has increased its kinetic efficiency and reduced its sensitivity towards the feedback inhibitors malate and aspartate.	Aspartic Acid	161-170	phosphoenolpyruvate carboxykinase 1	Homo sapiens	21-52
24192772-8	2013	Both patients showed major response to trabectedin, which was interestingly related with homozygoty of the common guanine allele of ERCC5 (G/G genotype; Asp/Asp) after pyrosenquencing analysis of tumors from both patients.	Aspartic Acid	153-156	ERCC excision repair 5, endonuclease	Homo sapiens	132-137
24192772-8	2013	Both patients showed major response to trabectedin, which was interestingly related with homozygoty of the common guanine allele of ERCC5 (G/G genotype; Asp/Asp) after pyrosenquencing analysis of tumors from both patients.	Aspartic Acid	157-160	ERCC excision repair 5, endonuclease	Homo sapiens	132-137
23527195-4	2013	Sequencing revealed a single novel mutation in LRRC6 (Leucine-rich repeat containing protein 6) that fit the model of autosomal recessive genetic transmission, leading to a change of a highly conserved amino acid from aspartic acid to histidine (Asp146His).	Aspartic Acid	218-231	dynein axonemal assembly factor 11	Homo sapiens	47-52
23527195-4	2013	Sequencing revealed a single novel mutation in LRRC6 (Leucine-rich repeat containing protein 6) that fit the model of autosomal recessive genetic transmission, leading to a change of a highly conserved amino acid from aspartic acid to histidine (Asp146His).	Aspartic Acid	218-231	dynein axonemal assembly factor 11	Homo sapiens	54-94
23818842-5	2013	As previously demonstrated for Pat2, we determined that 1) Pat1 is expressed and secreted into the host cytoplasm during R. typhi infection, 2) expression of recombinant Pat1 is cytotoxic to yeast cells, 3) recombinant Pat1 possesses PLA2 activity that requires a host cofactor, and 4) both Pat1 cytotoxicity and PLA2 activity were reduced by PLA2 inhibitors and abolished by site-directed mutagenesis of catalytic Ser/Asp residues.	Aspartic Acid	419-422	Pat1p	Saccharomyces cerevisiae S288C	59-63
23818842-5	2013	As previously demonstrated for Pat2, we determined that 1) Pat1 is expressed and secreted into the host cytoplasm during R. typhi infection, 2) expression of recombinant Pat1 is cytotoxic to yeast cells, 3) recombinant Pat1 possesses PLA2 activity that requires a host cofactor, and 4) both Pat1 cytotoxicity and PLA2 activity were reduced by PLA2 inhibitors and abolished by site-directed mutagenesis of catalytic Ser/Asp residues.	Aspartic Acid	419-422	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	Mus musculus	170-174
23818842-5	2013	As previously demonstrated for Pat2, we determined that 1) Pat1 is expressed and secreted into the host cytoplasm during R. typhi infection, 2) expression of recombinant Pat1 is cytotoxic to yeast cells, 3) recombinant Pat1 possesses PLA2 activity that requires a host cofactor, and 4) both Pat1 cytotoxicity and PLA2 activity were reduced by PLA2 inhibitors and abolished by site-directed mutagenesis of catalytic Ser/Asp residues.	Aspartic Acid	419-422	Pat1p	Saccharomyces cerevisiae S288C	170-174
23818842-5	2013	As previously demonstrated for Pat2, we determined that 1) Pat1 is expressed and secreted into the host cytoplasm during R. typhi infection, 2) expression of recombinant Pat1 is cytotoxic to yeast cells, 3) recombinant Pat1 possesses PLA2 activity that requires a host cofactor, and 4) both Pat1 cytotoxicity and PLA2 activity were reduced by PLA2 inhibitors and abolished by site-directed mutagenesis of catalytic Ser/Asp residues.	Aspartic Acid	419-422	Pat1p	Saccharomyces cerevisiae S288C	170-174
22453054-3	2012	Our previously published study reported a novel proteoglycan PTP1B inhibitor, named Fudan-Yueyang-Ganoderma lucidum (FYGL) from G. lucidum, with a half-maximal inhibitory concentration (IC50) value of 5 12 (sem 0 05) mug/ml, a protein:polyglycan ratio of 17:77 and 78 % glucose in polysaccharide, and dominant amino acid residues of aspartic acid, glycine, glutamic acid, alanine, serine and threonine in protein.	Aspartic Acid	333-346	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	61-66
24171321-3	2013	It is also known that Tyr-105, Glu-198 and Asp-158 of COX subunit II play roles in the enzyme"s catalysis but how these roles are linked to electron transfer remain unclear.	Aspartic Acid	43-46	cytochrome c oxidase subunit 7A1	Bos taurus	54-57
23285494-13	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
23285494-13	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
23022256-1	2012	Human SLC25A13 gene encodes citrin, the liver-type aspartate-glutamate carrier isoform 2, and SLC25A13 mutations lead to citrin deficiency (CD).	Aspartic Acid	51-60	solute carrier family 25 member 13	Homo sapiens	6-14
24485339-5	2013	While C-peptide and glucose were unaffected, a short-term increase in insulin was observed after the sucrose, but not after the aspartate or placebo.	Aspartic Acid	128-137	insulin	Homo sapiens	70-77
23246790-19	2012	TRIAL REGISTRATION: Dutch Trial Register (NTR): 2297: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2297 (Archived by WebCite at http://www.webcitation.org/65TkwoESp).	Aspartic Acid	105-108	neurotensin receptor 1	Homo sapiens	42-45
22242799-7	2012	Docking studies of beta3AR model with the known agonists enabled us to identify specific residues, viz, Asp 117, Ser 208, Ser 209, Ser 212, Arg 315, Asn 332, within the beta3AR binding pocket, which might play an important role in ligand binding.	Aspartic Acid	104-107	adrenoceptor beta 3	Homo sapiens	19-26
23135810-8	2012	Whereas, an analogous peptide, BDNF(1-12)D3N, in which the aspartate residue was substituted by an asparagine, was synthesized to provide evidence on the possible role of carboxylate group in Cu(2+) coordination.	Aspartic Acid	59-68	brain derived neurotrophic factor	Homo sapiens	31-35
23192044-4	2012	Recombinant human e5NT comprising four asparagine-to-aspartate surface mutations targeting potential glycosylation sites was refolded from bacterial inclusion bodies.	Aspartic Acid	53-62	5'-nucleotidase ecto	Homo sapiens	18-22
22242799-7	2012	Docking studies of beta3AR model with the known agonists enabled us to identify specific residues, viz, Asp 117, Ser 208, Ser 209, Ser 212, Arg 315, Asn 332, within the beta3AR binding pocket, which might play an important role in ligand binding.	Aspartic Acid	104-107	adrenoceptor beta 3	Homo sapiens	169-176
22819948-5	2012	The feedback-resistant DAHP synthase encoded by aroG was achieved by replacing the residue Leu175 of aroG with Asp as to increase net carbon flow down the common pathway.	Aspartic Acid	111-114	AroG	Escherichia coli	48-52
22819948-5	2012	The feedback-resistant DAHP synthase encoded by aroG was achieved by replacing the residue Leu175 of aroG with Asp as to increase net carbon flow down the common pathway.	Aspartic Acid	111-114	AroG	Escherichia coli	101-105
22271435-6	2012	In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and Asp/His genotypes of XPG, and Gln+ and Gln/Gln genotypes of XPD are more prevalent in patients than controls.	Aspartic Acid	57-60	X-ray repair cross complementing 1	Homo sapiens	103-108
22271435-6	2012	In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and Asp/His genotypes of XPG, and Gln+ and Gln/Gln genotypes of XPD are more prevalent in patients than controls.	Aspartic Acid	57-60	8-oxoguanine DNA glycosylase	Homo sapiens	167-172
22271435-6	2012	In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and Asp/His genotypes of XPG, and Gln+ and Gln/Gln genotypes of XPD are more prevalent in patients than controls.	Aspartic Acid	57-60	ERCC excision repair 5, endonuclease	Homo sapiens	204-207
22271435-6	2012	In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and Asp/His genotypes of XPG, and Gln+ and Gln/Gln genotypes of XPD are more prevalent in patients than controls.	Aspartic Acid	57-60	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	243-246
23038267-4	2012	Substrate screening determined that GADL1, unlike its name implies, has no detectable GAD activity, but it is able to efficiently catalyze decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine, and taurine, respectively.	Aspartic Acid	158-167	glutamate decarboxylase-like 1	Mus musculus	36-41
22975267-4	2012	Sequence comparison with other known secretory PLA2 shows that the enzyme isolated belongs to the group II, presenting an aspartic acid residue at position 48 (numbered by convention as Asp49) of the active site, and accordingly displaying enzymatic activity.	Aspartic Acid	122-135	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	47-51
23104058-4	2012	The crystal structure of the full-length Caenorhabditis elegans Tdp2 shows that this groove can also accommodate an acidic peptide stretch in vitro, with glutamate and aspartate side chains occupying the DNA backbone phosphate-binding sites.	Aspartic Acid	168-177	tyrosyl-DNA phosphodiesterase 2b	Danio rerio	64-68
22775331-7	2012	As demonstrated by mutational analysis, the aspartate at position 70 (D70) in the receiver domain of ARR18 acts as crucial phosphorylation site.	Aspartic Acid	44-53	response regulator 18	Arabidopsis thaliana	101-106
23112166-4	2012	Here, we used high-throughput microscopy analysis of yeast cells to determine changes in protein levels and localization as a result of a Glu to Asp mutation in the ATP binding site of subunits 3 (CCT3) or 6 (CCT6).	Aspartic Acid	145-148	chaperonin-containing T-complex subunit CCT3	Saccharomyces cerevisiae S288C	197-201
23181523-7	2012	We then demonstrated the differential effect of memantine, an N-Methyl-D-aspartic acid (NMDA) subunit selective weak inhibitor, in early and late AD pathology, and show that inhibition of the NMDA receptor NR2C/NR2D subunits located on inhibitory interneurons compensates for the greater excitatory decline observed with pathology.	Aspartic Acid	73-86	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	206-210
22992674-6	2012	In the present study, we find that mutation of NFAT5-T298 to alanine or aspartic acid not only reduces binding of NFAT5 to OREs (EMSA) but also proportionately reduces high NaCl-induced nuclear translocation of NFAT5.	Aspartic Acid	72-85	nuclear factor of activated T cells 5	Homo sapiens	47-52
22992674-6	2012	In the present study, we find that mutation of NFAT5-T298 to alanine or aspartic acid not only reduces binding of NFAT5 to OREs (EMSA) but also proportionately reduces high NaCl-induced nuclear translocation of NFAT5.	Aspartic Acid	72-85	nuclear factor of activated T cells 5	Homo sapiens	114-119
22992674-6	2012	In the present study, we find that mutation of NFAT5-T298 to alanine or aspartic acid not only reduces binding of NFAT5 to OREs (EMSA) but also proportionately reduces high NaCl-induced nuclear translocation of NFAT5.	Aspartic Acid	72-85	nuclear factor of activated T cells 5	Homo sapiens	114-119
23151220-3	2012	METHODS: We compared the CD44 alternative splice pattern (ASP) of three genetically different human colorectal cancer cell lines (HT25, HT29, HCT116) using a series of PCR reactions and next- generation sequencing method, as well as identified a colorectal adenocarcinoma specific CD44 ASP.	Aspartic Acid	58-61	CD44 molecule (Indian blood group)	Homo sapiens	25-29
23112166-4	2012	Here, we used high-throughput microscopy analysis of yeast cells to determine changes in protein levels and localization as a result of a Glu to Asp mutation in the ATP binding site of subunits 3 (CCT3) or 6 (CCT6).	Aspartic Acid	145-148	chaperonin-containing T-complex subunit CCT6	Saccharomyces cerevisiae S288C	209-213
23141068-4	2012	Crystallographic and mutation analyses revealed that a specific zinc binding site is formed at the base of the ligand binding domain (LBD) dimer interface by a GluK3-specific aspartate (Asp759), together with two conserved residues, His762 and Asp730, the latter located on the partner subunit.	Aspartic Acid	175-184	glutamate ionotropic receptor kainate type subunit 3	Homo sapiens	160-165
22969039-11	2012	The third and most important binding determinant is the positive charge on the ligand, which is neutralised by Asp 518 or Asp 616 on GAA.	Aspartic Acid	111-114	alpha glucosidase	Homo sapiens	133-136
22969085-6	2012	Based on reported mutagenesis data and comparison of the VanG and VanA structures, we show that residues Asp-243, Phe-252, and Arg-324 are molecular determinants for d-Ser selectivity.	Aspartic Acid	105-108	VanA	Enterococcus faecalis	66-70
22969039-11	2012	The third and most important binding determinant is the positive charge on the ligand, which is neutralised by Asp 518 or Asp 616 on GAA.	Aspartic Acid	122-125	alpha glucosidase	Homo sapiens	133-136
23152013-3	2012	However, pooled analysis of randomized controlled studies in Western countries in patients treated with cetuximab has suggested that patients with tumors showing the KRAS p. G13D mutation[a glycine(G)to aspartate(D)transition mutation] have longer overall survival and progression-free survival when compared to patients with other KRAS mutations.	Aspartic Acid	203-212	KRAS proto-oncogene, GTPase	Homo sapiens	166-170
22835831-7	2012	Recombinant Nna1 metabolizes synthetic substrates with 2 or more C-terminal glutamate (but not aspartate) residues (V(max) for 3 glutamates is ~7-fold higher than 2 glutamates although K(M) is similar).	Aspartic Acid	95-104	ATP/GTP binding protein 1	Mus musculus	12-16
23152013-3	2012	However, pooled analysis of randomized controlled studies in Western countries in patients treated with cetuximab has suggested that patients with tumors showing the KRAS p. G13D mutation[a glycine(G)to aspartate(D)transition mutation] have longer overall survival and progression-free survival when compared to patients with other KRAS mutations.	Aspartic Acid	203-212	KRAS proto-oncogene, GTPase	Homo sapiens	332-336
22711503-6	2012	Further mutagenesis of this motif shows that amino acid residue aspartic acid (D) 16 of BMRP is essential for the BMRP/Bcl-2 interaction.	Aspartic Acid	64-77	mitochondrial ribosomal protein L41	Homo sapiens	88-92
22762973-3	2012	hPRR2 has the prorenin-binding domain inserted between amino acid residues (81)Asp and (82)Pro of GP64.	Aspartic Acid	79-82	nectin cell adhesion molecule 2	Homo sapiens	0-5
22762973-4	2012	hPRR4 has the prorenin-binding domain inserted in (81)Asp and (320)Met of partially deleted GP64.	Aspartic Acid	54-57	proline rich 4	Homo sapiens	0-5
22711503-6	2012	Further mutagenesis of this motif shows that amino acid residue aspartic acid (D) 16 of BMRP is essential for the BMRP/Bcl-2 interaction.	Aspartic Acid	64-77	mitochondrial ribosomal protein L41	Homo sapiens	114-118
22711503-6	2012	Further mutagenesis of this motif shows that amino acid residue aspartic acid (D) 16 of BMRP is essential for the BMRP/Bcl-2 interaction.	Aspartic Acid	64-77	BCL2 apoptosis regulator	Homo sapiens	119-124
22951399-8	2012	Furthermore, we demonstrate that aspartate phosphorylation of ARR4 is only required for the H2O2- but not for the ethylene-induced stomatal closure response.	Aspartic Acid	33-42	response regulator 4	Arabidopsis thaliana	62-66
22820273-1	2012	The human CHRNA5 D398N polymorphism (rs16969968) causes an aspartic acid to asparagine change in the nicotinic acetylcholine receptor (nAChR) alpha5 subunit gene.	Aspartic Acid	59-72	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	10-16
22382901-0	2012	Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation.	Aspartic Acid	0-13	monoamine oxidase A	Homo sapiens	31-50
22382901-3	2012	We substituted three aspartic acid (D) residues in human MAO-A that reside in putative Ca2+-binding motifs and overexpressed the individual proteins in the human HEK293 cell line.	Aspartic Acid	21-34	monoamine oxidase A	Homo sapiens	57-62
22779803-4	2012	One aspartic acid, Asp98 in transmembrane domain 7 (TM3), has been identified as major contributors to ligand binding by H-bond interactions.	Aspartic Acid	4-17	tropomyosin 3	Homo sapiens	52-55
22904271-6	2012	This role of ADAM15 depended on intact functioning of the cytoplasmic domain, as evidenced in experiments with site-directed mutagenesis targeting the metalloprotease active site (E349A), the disintegrin domain (Arginine-Glycine-Aspartic acid Threonine-Aspartic acid-Aspartic acid), or the cytoplasmic tail.	Aspartic Acid	229-242	a disintegrin and metallopeptidase domain 15 (metargidin)	Mus musculus	13-19
22930753-9	2012	Our results suggest that external Zn(2+) regulates ENaC activity by binding to multiple extracellular sites within the gamma-subunit, including (i) a high-affinity stimulatory site within the finger subdomain involving His(193), His(200), and His(202) and (ii) a low-affinity Zn(2+) inhibitory site within the palm subdomain that includes His(88) and Asp(516).	Aspartic Acid	351-354	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
22991464-8	2012	Biochemical data reveal that conserved aspartate residues in PRORP1 are important for catalytic activity and metal binding and that the PPR domain also enhances activity, likely through an interaction with pre-tRNA.	Aspartic Acid	39-48	proteinaceous RNase P 1	Arabidopsis thaliana	61-67
23115806-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
23115806-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
22898812-5	2012	Mutating Ser-340/341 in the N-ATP7B individually or together to Ala, Gly, Thr, or Asp produced active protein and shifted the steady-state localization of ATP7B to vesicles, independently of copper levels.	Aspartic Acid	82-85	ATPase copper transporting beta	Homo sapiens	30-35
22898812-5	2012	Mutating Ser-340/341 in the N-ATP7B individually or together to Ala, Gly, Thr, or Asp produced active protein and shifted the steady-state localization of ATP7B to vesicles, independently of copper levels.	Aspartic Acid	82-85	ATPase copper transporting beta	Homo sapiens	155-160
22825847-4	2012	We confirmed that Asp(563) in eukaryotic translation initiation factor 4B (eIF4B) is a cleavage site preferred by caspase-2 not only in COFRADIC setup but also upon co-expression in HEK 293T cells.	Aspartic Acid	18-21	eukaryotic translation initiation factor 4B	Homo sapiens	30-73
22825847-4	2012	We confirmed that Asp(563) in eukaryotic translation initiation factor 4B (eIF4B) is a cleavage site preferred by caspase-2 not only in COFRADIC setup but also upon co-expression in HEK 293T cells.	Aspartic Acid	18-21	eukaryotic translation initiation factor 4B	Homo sapiens	75-80
22825847-4	2012	We confirmed that Asp(563) in eukaryotic translation initiation factor 4B (eIF4B) is a cleavage site preferred by caspase-2 not only in COFRADIC setup but also upon co-expression in HEK 293T cells.	Aspartic Acid	18-21	caspase 2	Homo sapiens	114-123
22728886-0	2012	Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid.	Aspartic Acid	83-96	elastin	Homo sapiens	13-20
22904271-6	2012	This role of ADAM15 depended on intact functioning of the cytoplasmic domain, as evidenced in experiments with site-directed mutagenesis targeting the metalloprotease active site (E349A), the disintegrin domain (Arginine-Glycine-Aspartic acid Threonine-Aspartic acid-Aspartic acid), or the cytoplasmic tail.	Aspartic Acid	253-266	a disintegrin and metallopeptidase domain 15 (metargidin)	Mus musculus	13-19
22831553-0	2012	Synthesis and biological evaluation of a novel (177)Lu-DOTA-[Gly(3)-cyclized(Dap(4), (d)-Phe(7), Asp(10))-Arg(11)]alpha-MSH(3-13) analogue for melanocortin-1 receptor-positive tumor targeting.	Aspartic Acid	97-100	DLG associated protein 4	Homo sapiens	77-82
23089609-5	2012	The ASP-inhibitor complex in ASP-added plasma was not detected by immunoblotting using anti-ASP antibody; however, using gel filtration of the plasma ASP activity for an oligopeptide, the ASP substrate was eluted in the void fraction (Mw&gt;200 000), suggesting ASP trapping by alpha2-MG.	Aspartic Acid	4-7	alpha-2-macroglobulin	Homo sapiens	278-287
23089609-5	2012	The ASP-inhibitor complex in ASP-added plasma was not detected by immunoblotting using anti-ASP antibody; however, using gel filtration of the plasma ASP activity for an oligopeptide, the ASP substrate was eluted in the void fraction (Mw&gt;200 000), suggesting ASP trapping by alpha2-MG.	Aspartic Acid	29-32	alpha-2-macroglobulin	Homo sapiens	278-287
23089609-5	2012	The ASP-inhibitor complex in ASP-added plasma was not detected by immunoblotting using anti-ASP antibody; however, using gel filtration of the plasma ASP activity for an oligopeptide, the ASP substrate was eluted in the void fraction (Mw&gt;200 000), suggesting ASP trapping by alpha2-MG.	Aspartic Acid	29-32	alpha-2-macroglobulin	Homo sapiens	278-287
23089609-5	2012	The ASP-inhibitor complex in ASP-added plasma was not detected by immunoblotting using anti-ASP antibody; however, using gel filtration of the plasma ASP activity for an oligopeptide, the ASP substrate was eluted in the void fraction (Mw&gt;200 000), suggesting ASP trapping by alpha2-MG.	Aspartic Acid	29-32	alpha-2-macroglobulin	Homo sapiens	278-287
23089609-5	2012	The ASP-inhibitor complex in ASP-added plasma was not detected by immunoblotting using anti-ASP antibody; however, using gel filtration of the plasma ASP activity for an oligopeptide, the ASP substrate was eluted in the void fraction (Mw&gt;200 000), suggesting ASP trapping by alpha2-MG.	Aspartic Acid	29-32	alpha-2-macroglobulin	Homo sapiens	278-287
23089609-6	2012	Indeed, human alpha2-MG inhibited ASP azocaseinolytic activity in a dose-dependent manner, rapidly forming a complex with the ASP.	Aspartic Acid	34-37	alpha-2-macroglobulin	Homo sapiens	14-23
22831553-0	2012	Synthesis and biological evaluation of a novel (177)Lu-DOTA-[Gly(3)-cyclized(Dap(4), (d)-Phe(7), Asp(10))-Arg(11)]alpha-MSH(3-13) analogue for melanocortin-1 receptor-positive tumor targeting.	Aspartic Acid	97-100	proopiomelanocortin	Homo sapiens	114-123
22831553-0	2012	Synthesis and biological evaluation of a novel (177)Lu-DOTA-[Gly(3)-cyclized(Dap(4), (d)-Phe(7), Asp(10))-Arg(11)]alpha-MSH(3-13) analogue for melanocortin-1 receptor-positive tumor targeting.	Aspartic Acid	97-100	melanocortin 1 receptor	Homo sapiens	143-166
23089609-6	2012	Indeed, human alpha2-MG inhibited ASP azocaseinolytic activity in a dose-dependent manner, rapidly forming a complex with the ASP.	Aspartic Acid	126-129	alpha-2-macroglobulin	Homo sapiens	14-23
23089609-7	2012	Fibrinogen degradation by ASP was completely inhibited in the presence of alpha2-MG.	Aspartic Acid	26-29	alpha-2-macroglobulin	Homo sapiens	74-83
22733492-10	2012	Prediction of the 3-D structure shows mutations 36Asp   Asn, 38Asn   Asp and 43 Ile   Thr were on the concave surface of LBP protein at barrel-N, 67Ala   Thr was in the apolar pocket at barrel-N. Motif analysis shows 36Asp   Asn causes loss of a CK2 phosphorylation site, 67 Ala   Thr forms a new PKC phosphorylation site.	Aspartic Acid	50-53	lipopolysaccharide binding protein	Bos taurus	121-124
23089609-10	2012	Thus, alpha2-MG is the major ASP inhibitor in the human plasma and can limit ASP virulence activities in A. sobria infection sites.	Aspartic Acid	29-32	alpha-2-macroglobulin	Homo sapiens	6-15
23089609-10	2012	Thus, alpha2-MG is the major ASP inhibitor in the human plasma and can limit ASP virulence activities in A. sobria infection sites.	Aspartic Acid	77-80	alpha-2-macroglobulin	Homo sapiens	6-15
23089609-11	2012	However, as shown by fluorescence correlation spectroscopy, slow ASP inhibition by alpha2-MG in plasma may indicate insufficient ASP control in vivo.	Aspartic Acid	65-68	alpha-2-macroglobulin	Homo sapiens	83-92
22985399-4	2012	A previous study indicated that ASP may increase plasma iron levels by suppressing the expression of hepcidin, a negative regulator of body iron metabolism, in the liver.	Aspartic Acid	32-35	hepcidin antimicrobial peptide	Rattus norvegicus	101-109
22985399-5	2012	The present study aims to clarify the inhibitory effect of ASP on hepcidin expression in rat models of iron deficiency anemia (IDA), and clarify the mechanisms involved.	Aspartic Acid	59-62	hepcidin antimicrobial peptide	Rattus norvegicus	66-74
22985399-7	2012	The results indicate that ASP can suppress the expression of hepcidin in rats with IDA, and may be useful for the treatment of IDA.	Aspartic Acid	26-29	hepcidin antimicrobial peptide	Rattus norvegicus	61-69
22843197-3	2012	Recently, it was found that a mutation at the third position of hCx46 that substituted an aspartic acid residue with a tyrosine residue (hCx46D3Y) caused an autosomal dominant zonular pulverulent cataract.	Aspartic Acid	90-103	gap junction protein alpha 3	Homo sapiens	64-69
22843197-10	2012	These results indicate that the negatively charged aspartic acid residue at the third position of the N-terminus of hCx46 could be involved in the determination of the degree of metabolite cell-to-cell coupling and is essential for the voltage sensitivity of the hCx46 hemichannels.	Aspartic Acid	51-64	gap junction protein alpha 3	Homo sapiens	116-121
22843197-10	2012	These results indicate that the negatively charged aspartic acid residue at the third position of the N-terminus of hCx46 could be involved in the determination of the degree of metabolite cell-to-cell coupling and is essential for the voltage sensitivity of the hCx46 hemichannels.	Aspartic Acid	51-64	gap junction protein alpha 3	Homo sapiens	263-268
22872754-7	2012	Mutation of this serine to aspartic acid, simulating a constitutively phosphorylated state, resulted in accelerated degradation of ABCG1(+12) and reduced cholesterol export.	Aspartic Acid	27-40	ATP binding cassette subfamily G member 1	Homo sapiens	131-136
22825851-7	2012	Residues in sizzled required for inhibition include Asp-92, which is shared by sFRP-1 and -2, and also Phe-94, Ser-43, and Glu-44, which are specific to sizzled, thereby providing a rational basis for the absence of inhibitory activity of human sFRPs.	Aspartic Acid	52-55	secreted frizzled related protein 1	Homo sapiens	79-92
22944204-4	2012	The expression plasmid contained a gene fragment encoding the Tat-HA-NR2B9c was ligated to the C-terminal fragment of l-asparaginase (AnsB-C) via a unique acid labile Asp-Pro linker.	Aspartic Acid	167-170	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	69-75
22944204-4	2012	The expression plasmid contained a gene fragment encoding the Tat-HA-NR2B9c was ligated to the C-terminal fragment of l-asparaginase (AnsB-C) via a unique acid labile Asp-Pro linker.	Aspartic Acid	167-170	asparaginase and isoaspartyl peptidase 1	Homo sapiens	118-132
26835269-1	2012	OBJECTIVE: To amplify the entire ORF of SLC25A13 cDNA which encodes citrin, a liver-type mitochondrial aspartate-glutamate carrier, and to investigate sequence feature of the transcripts for this gene in cultured human amniocytes.	Aspartic Acid	103-112	solute carrier family 25 member 13	Homo sapiens	40-48
26835269-1	2012	OBJECTIVE: To amplify the entire ORF of SLC25A13 cDNA which encodes citrin, a liver-type mitochondrial aspartate-glutamate carrier, and to investigate sequence feature of the transcripts for this gene in cultured human amniocytes.	Aspartic Acid	103-112	solute carrier family 25 member 13	Homo sapiens	68-74
22901043-7	2012	In human AChE, certain aryl residues in the vicinity of the anionic aspartate residue (D74), such as W286, have been implicated in ligand binding and have therefore been considered part of the P-site of the enzyme.	Aspartic Acid	68-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	9-13
22875854-10	2012	All Asp(374) mutations resulted in similar gain-of-function activity on the LDLR except that D374E was as active as native PCSK9, D374G was relatively less active, and D374N and D374P were completely inactive.	Aspartic Acid	4-7	low density lipoprotein receptor	Homo sapiens	76-80
22879599-0	2012	Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39).	Aspartic Acid	49-52	G protein-coupled receptor 39	Homo sapiens	95-100
22879599-12	2012	This indicates that Asp(313), which was shown to modulate Zn(2+) binding, is an essential residue of the pH sensor of GPR39.	Aspartic Acid	20-23	G protein-coupled receptor 39	Homo sapiens	118-123
22871268-6	2012	In the presence of TTX both the NMDA receptor antagonist D-AP5 and the AMPA/kainate receptor antagonist CNQX reduced and the co-application of these two antagonists almost abolished the postsynaptic effects of l-Asp and l-Glu in a reversible manner.	Aspartic Acid	210-215	eukaryotic translation initiation factor 4 gamma 2	Gallus gallus	57-62
22876914-7	2012	Leu and Asp residues in the consensus sequence were identified to be critical for binding to GIP through site-directed mutagenesis studies.	Aspartic Acid	8-11	gastric inhibitory polypeptide	Homo sapiens	93-96
22876914-8	2012	Structure-based models of GIP bound to two different surrogate peptides determined from nuclear magnetic resonance constraints revealed that the binding pocket is flexible enough to accommodate either the smaller carboxylate (COO(-)) group of a C-terminal recognition motif or the bulkier aspartate side chain (CH(2)COO(-)) of an internal motif.	Aspartic Acid	289-298	gastric inhibitory polypeptide	Homo sapiens	26-29
22809627-6	2012	Conversely, substitution with the sulfinic acid mimic aspartic acid resulted in constitutive Hsf1 activation.	Aspartic Acid	54-67	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	93-97
22684024-7	2012	Another major finding was that Ala and Asp substitutions in cTnI did not affect crossbridge detachment kinetics.	Aspartic Acid	39-42	troponin I3, cardiac type	Rattus norvegicus	60-64
22710133-1	2012	Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is an autosomal recessive disease caused by the dysfunction of citrin, an aspartate/glutamate carrier encoded by the SLC25A13 gene.	Aspartic Acid	144-153	solute carrier family 25 member 13	Homo sapiens	44-50
22710133-1	2012	Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is an autosomal recessive disease caused by the dysfunction of citrin, an aspartate/glutamate carrier encoded by the SLC25A13 gene.	Aspartic Acid	144-153	solute carrier family 25 member 13	Homo sapiens	187-195
22622423-8	2012	Neutralization of an aspartic acid residue (D641) in the extracellular pore loop or two acidic residues (E679, E682) in the inner pore region significantly attenuated the inhibitory effect of extracellular or intracellular Mg(2+) on TRPV3-mediated signaling, respectively.	Aspartic Acid	21-34	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	233-238
22639060-8	2012	However, a serine to aspartic acid mutation results in the cytoplasmic localization of Olig1 enhancing membrane expansion.	Aspartic Acid	21-34	oligodendrocyte transcription factor 1	Homo sapiens	87-92
22356135-6	2012	However, it may be overcome by continuous action of L-Asp, which is mirrored by increased aspartic acid levels but unchanged low asparagine levels in BM, suggesting a higher BM turnover of asparagine generated by L-Asp during induction therapy.	Aspartic Acid	90-103	asparaginase and isoaspartyl peptidase 1	Homo sapiens	52-57
21968931-11	2012	In this risk region, there is a common (among European-origin people) mis-sense single-nucleotide polymorphism in the CHRNA5 gene (D398N), which changes a conserved amino acid from aspartic acid to asparagine.	Aspartic Acid	181-194	cholinergic receptor nicotinic alpha 5 subunit	Homo sapiens	118-124
23050239-11	2012	These properties may be explained by the recent identification of an aspartate in the pore of H(V)1 that is essential to its proton selectivity.	Aspartic Acid	69-78	hydrogen voltage gated channel 1	Homo sapiens	94-99
22542772-0	2012	siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate.	Aspartic Acid	166-175	glutamate dehydrogenase 1	Homo sapiens	20-43
22542772-9	2012	The (15)N incorporation from [(15)NH(4)(+)] into glutamate, aspartate and alanine was decreased in astrocytes exhibiting reduced GDH activity.	Aspartic Acid	60-69	glutamate dehydrogenase 1	Homo sapiens	129-132
22542772-12	2012	In contrast, when exposing the astrocytes to [(15)N]glutamate, the reduced GDH activity led to an increased (15)N incorporation into glutamate, aspartate and alanine and a large increase in the content of glutamate and aspartate.	Aspartic Acid	144-153	glutamate dehydrogenase 1	Homo sapiens	75-78
22542772-12	2012	In contrast, when exposing the astrocytes to [(15)N]glutamate, the reduced GDH activity led to an increased (15)N incorporation into glutamate, aspartate and alanine and a large increase in the content of glutamate and aspartate.	Aspartic Acid	219-228	glutamate dehydrogenase 1	Homo sapiens	75-78
22542772-14	2012	We suggest that this extensive net-synthesis of aspartate due to lack of GDH activity is occurring via the concerted action of AAT and the part of TCA cycle operating from alpha-ketoglutarate to oxaloacetate, i.e. the truncated TCA cycle.	Aspartic Acid	48-57	glutamate dehydrogenase 1	Homo sapiens	73-76
22542772-14	2012	We suggest that this extensive net-synthesis of aspartate due to lack of GDH activity is occurring via the concerted action of AAT and the part of TCA cycle operating from alpha-ketoglutarate to oxaloacetate, i.e. the truncated TCA cycle.	Aspartic Acid	48-57	serpin family A member 1	Homo sapiens	127-130
22451646-5	2012	We found that Prf variants with single amino acid substitutions at D1416 in the IHD motif (isoleucine-histidine-aspartic acid) in the NBARC domain cause effector-independent PCD when transiently expressed in leaves of Nicotiana benthamiana, suggesting D1416 plays an important role in activation of Prf.	Aspartic Acid	112-125	putative late blight resistance protein homolog R1A-4	Solanum lycopersicum	14-17
22451646-5	2012	We found that Prf variants with single amino acid substitutions at D1416 in the IHD motif (isoleucine-histidine-aspartic acid) in the NBARC domain cause effector-independent PCD when transiently expressed in leaves of Nicotiana benthamiana, suggesting D1416 plays an important role in activation of Prf.	Aspartic Acid	112-125	putative late blight resistance protein homolog R1A-4	Solanum lycopersicum	299-302
22761414-1	2012	Cited2 (CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modulator critical for the development of multiple organs.	Aspartic Acid	67-80	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	0-6
22761414-1	2012	Cited2 (CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modulator critical for the development of multiple organs.	Aspartic Acid	67-80	CREB binding protein	Mus musculus	8-11
22761414-1	2012	Cited2 (CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modulator critical for the development of multiple organs.	Aspartic Acid	67-80	E1A binding protein p300	Mus musculus	12-16
22440693-1	2012	Aminopeptidase A (APA) and aspartyl aminopeptidase (ASAP) not only act as neuromodulators in the regional brain renin-angiotensin system, but also release N-terminal acidic amino acids (glutamate and aspartate).	Aspartic Acid	200-209	glutamyl aminopeptidase	Mus musculus	0-16
22795331-0	2012	Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket.	Aspartic Acid	99-102	ketohexokinase	Homo sapiens	35-49
22575890-8	2012	A unique inactivation mechanism is also revealed, which does not make use of a lysine against the catalytic aspartates, probably in order to facilitate pH-independent activation [e.g., by the (pro)renin receptor].	Aspartic Acid	108-118	renin	Homo sapiens	197-202
22753194-8	2012	Mutation of S47 to nonphosphorable alanine (S47A) enhanced whereas replacing S47 with phospho-mimicking aspartic acid (S47D) abolished the antisenescent, growth-promoting, and LKB1-downregulating actions of SIRT1.	Aspartic Acid	104-117	serine/threonine kinase 11	Mus musculus	176-180
22587366-5	2012	Using a three-dimensional model of Pho84 created on the basis of the GlpT permease, complemented with multiple sequence alignments, we selected Arg(168) and Lys(492), and Asp(178), Asp(358) and Glu(473) as residues potentially involved in phosphate or proton binding respectively, during transport.	Aspartic Acid	181-184	phosphate transporter PHO84	Saccharomyces cerevisiae S288C	35-40
22587366-6	2012	We found that Asp(358) (helix 7) and Lys(492) (helix 11) are critical for the transport function, and might be part of the putative substrate-binding pocket of Pho84.	Aspartic Acid	14-17	phosphate transporter PHO84	Saccharomyces cerevisiae S288C	160-165
22977870-1	2012	Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively.	Aspartic Acid	23-26	vimentin	Mus musculus	91-99
22560646-5	2012	Considering Asp299Gly replacement of TLR4 gene, Gly carriers (Asp/Gly &amp; Gly/Gly genotype) and Gly allele were overrepresented among the breast cancer cases.	Aspartic Acid	12-15	toll like receptor 4	Homo sapiens	37-41
22977870-1	2012	Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively.	Aspartic Acid	23-26	lamin A	Mus musculus	130-137
22977870-1	2012	Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively.	Aspartic Acid	23-26	lamin A	Mus musculus	139-146
22692213-7	2012	The BACE1 cleavage sites at the membrane-proximal regions of L1 (between Tyr(1086) and Glu(1087)) and CHL1 (between Gln(1061) and Asp(1062)) were determined by mass spectrometry.	Aspartic Acid	130-133	beta-site APP cleaving enzyme 1	Mus musculus	4-9
21544638-3	2012	MBL2 promoter polymorphisms at -550 (H/L), -221 (Y/X), +4 (P/Q), and exon polymorphisms at codon 52 (Arg/Cys), 54 (Gly/Asp, or A/B), and 57 (Gly/Glu) were investigated using polymerase chain reaction and restriction fragment length polymorphism.	Aspartic Acid	119-122	mannose binding lectin 2	Homo sapiens	0-4
22472605-3	2012	The study is based on Bayesian flux balance analysis, which uses Markov chain Monte Carlo sampling techniques and provides a quantitative description of steady states when the two exchangers aspartate-glutamate carrier (AGC1) and oxoglutarate carrier (OGC) in the malate-aspartate shuttle in astrocyte are not in equilibrium, as recent studies suggest.	Aspartic Acid	191-200	aggrecan	Homo sapiens	220-224
22472605-3	2012	The study is based on Bayesian flux balance analysis, which uses Markov chain Monte Carlo sampling techniques and provides a quantitative description of steady states when the two exchangers aspartate-glutamate carrier (AGC1) and oxoglutarate carrier (OGC) in the malate-aspartate shuttle in astrocyte are not in equilibrium, as recent studies suggest.	Aspartic Acid	271-280	aggrecan	Homo sapiens	220-224
22381782-3	2012	METHODS: Several new BN derivatives with the common structure MAG(3)-X-BN(1-14 or 6-14), where X=Asp or Asp-Asp, were synthesized by solid-phase peptide synthesis.	Aspartic Acid	97-100	gastrin releasing peptide	Homo sapiens	21-23
22692213-7	2012	The BACE1 cleavage sites at the membrane-proximal regions of L1 (between Tyr(1086) and Glu(1087)) and CHL1 (between Gln(1061) and Asp(1062)) were determined by mass spectrometry.	Aspartic Acid	130-133	cell adhesion molecule L1-like	Mus musculus	102-106
22764235-7	2012	RGD (arginine-glycine-aspartic acid) blocking peptides induced CNTF expression, which was dependent on transcription.	Aspartic Acid	22-35	ciliary neurotrophic factor	Mus musculus	63-67
22314869-4	2012	This new probe, 2SBPO-Casp, was synthesized by coupling a water-soluble Nile Blue derivative (2SBPO) to an aspartic acid residue.	Aspartic Acid	107-120	cut like homeobox 1	Homo sapiens	22-26
22577142-2	2012	In eukaryotes, the major way to generate N-degrons is through arginylation by ATE1 arginyl-tRNA-protein transferases, which transfer Arg from aminoacyl-tRNA to N-terminal Asp and Glu (and Cys as well in mammals).	Aspartic Acid	171-174	arginyltransferase 1	Mus musculus	78-82
22686285-1	2012	Poly(ethylene glycol)-block-poly(partially benzyl-esterified aspartic acid), denoted by PEG-P(Asp(Bzl)), is one of the most examined blockcopolymers for drug carriers.	Aspartic Acid	61-74	progestagen associated endometrial protein	Homo sapiens	88-91
22686285-1	2012	Poly(ethylene glycol)-block-poly(partially benzyl-esterified aspartic acid), denoted by PEG-P(Asp(Bzl)), is one of the most examined blockcopolymers for drug carriers.	Aspartic Acid	94-97	progestagen associated endometrial protein	Homo sapiens	88-91
22490677-7	2012	This correspondence is demonstrated by binding of integrin alpha(IIb)beta(3) to the fourth module seen in EM, VWC4, which bears the VWF Arg-Gly-Asp motif.	Aspartic Acid	144-147	von Willebrand factor	Homo sapiens	132-135
22829704-3	2012	Integrin-ECM interaction was inhibited with anti-beta1-integrin monoclonal antibody (mAb) or RGDS (Arg-Gly-Asp-Ser).	Aspartic Acid	107-110	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	93-97
22747601-6	2012	Remarkably, despite replacement of the Asp ligand, zinc binding is retained at the S100A15 dimer interface with distorted tetrahedral geometry and a chloride ion serving as an exogenous fourth ligand.	Aspartic Acid	39-42	S100 calcium binding protein A7A	Homo sapiens	83-90
22539596-3	2012	Cadherin 6 is expressed on the platelet surface and contains an arginine-glycine-aspartic acid motif, suggesting that it might have a supportive role in thrombus formation.	Aspartic Acid	81-94	cadherin 6	Mus musculus	0-10
22539596-6	2012	Platelet adhesion to immobilized cadherin 6 was inhibited by arginine-glycine-aspartic acid-serine tetrapeptides.	Aspartic Acid	78-91	cadherin 6	Mus musculus	33-43
22356656-0	2012	Inherited or de novo mutation affecting aspartate 18 of TREX1 results in either familial chilblain lupus or Aicardi-Goutieres syndrome.	Aspartic Acid	40-49	three prime repair exonuclease 1	Homo sapiens	56-61
22484197-6	2012	PEG-SS-P[Asp(DET)] micelle encapsulating human tumor necrosis factor alpha (hTNF-alpha) gene exhibits a higher antitumor efficacy against disseminated cancer compared with PEG-P[Asp(DET)] or saline control.	Aspartic Acid	9-12	tumor necrosis factor	Homo sapiens	47-74
22484197-6	2012	PEG-SS-P[Asp(DET)] micelle encapsulating human tumor necrosis factor alpha (hTNF-alpha) gene exhibits a higher antitumor efficacy against disseminated cancer compared with PEG-P[Asp(DET)] or saline control.	Aspartic Acid	9-12	tumor necrosis factor	Homo sapiens	76-86
22697172-1	2012	Thermodynamic and surface-specific spectroscopic investigations were carried with an elastin-like polypeptide (ELP) containing 16 aspartic acid residues.	Aspartic Acid	130-143	nuclear receptor subfamily 5 group A member 1	Homo sapiens	111-114
22697172-1	2012	Thermodynamic and surface-specific spectroscopic investigations were carried with an elastin-like polypeptide (ELP) containing 16 aspartic acid residues.	Aspartic Acid	130-143	nuclear receptor subfamily 5 group A member 1	Homo sapiens	85-109
22532568-0	2012	Neutralizing aspartate 83 modifies substrate translocation of excitatory amino acid transporter 3 (EAAT3) glutamate transporters.	Aspartic Acid	13-22	solute carrier family 1 member 1	Homo sapiens	99-104
22523075-3	2012	Here, we present the crystal structure of a GRASP phosphomimic containing an aspartic acid substitution for a serine residue (Ser-189) that in GRASP65 is phosphorylated by PLK1, causing a block in membrane tethering and Golgi ribbon formation.	Aspartic Acid	77-90	trafficking regulator and scaffold protein tamalin	Homo sapiens	44-49
22591353-1	2012	The DNMT2 enzyme methylates tRNA-Asp at position C38.	Aspartic Acid	33-36	tRNA aspartic acid methyltransferase 1	Homo sapiens	4-9
22523075-3	2012	Here, we present the crystal structure of a GRASP phosphomimic containing an aspartic acid substitution for a serine residue (Ser-189) that in GRASP65 is phosphorylated by PLK1, causing a block in membrane tethering and Golgi ribbon formation.	Aspartic Acid	77-90	golgi reassembly stacking protein 1	Homo sapiens	143-150
22523075-3	2012	Here, we present the crystal structure of a GRASP phosphomimic containing an aspartic acid substitution for a serine residue (Ser-189) that in GRASP65 is phosphorylated by PLK1, causing a block in membrane tethering and Golgi ribbon formation.	Aspartic Acid	77-90	polo like kinase 1	Homo sapiens	172-176
22560905-2	2012	The integrins recognize a short tripeptide motif of arg-lys-cys (RKC) in CD23, and peptides containing this motif inhibit the binding of CD23 to B cells and monocytes; neither fibronectin, nor vitronectin, which contain arg-gly-asp motifs, inhibit binding of RKC-containing peptides to cells.	Aspartic Acid	228-231	Fc epsilon receptor II	Homo sapiens	137-141
22615398-5	2012	Side-chain carboxylates of glutamates and aspartates in the C terminus of Geminin generate an overall charge pattern resembling the DNA phosphate backbone.	Aspartic Acid	42-52	geminin DNA replication inhibitor	Homo sapiens	74-81
22495673-3	2012	The aspartic acid changes at position 89 to either Ala, Leu, or Arg generated mutant receptors with varying expression profiles and a complete inability to bind somatostatin-14 (SST).	Aspartic Acid	4-17	somatostatin	Homo sapiens	161-176
22527282-8	2012	Liar also showed reduced binding to an aspartic acid phosphomimetic SH3 mutant.	Aspartic Acid	39-52	ankyrin repeat domain 54	Homo sapiens	0-4
22573621-4	2012	Loss of Hox1 function resulted in loss of the ASP, which could be rescued by expressing Hox1 in the epidermis.	Aspartic Acid	46-49	homeobox transcription factor Hox1	Ciona intestinalis	8-12
22573621-4	2012	Loss of Hox1 function resulted in loss of the ASP, which could be rescued by expressing Hox1 in the epidermis.	Aspartic Acid	46-49	homeobox transcription factor Hox1	Ciona intestinalis	88-92
22573621-6	2012	We showed that abolishment of RA resulted in loss of the ASP, which could be rescued by forced expression of Hox1 in the epidermis.	Aspartic Acid	57-60	homeobox transcription factor Hox1	Ciona intestinalis	109-113
22495673-3	2012	The aspartic acid changes at position 89 to either Ala, Leu, or Arg generated mutant receptors with varying expression profiles and a complete inability to bind somatostatin-14 (SST).	Aspartic Acid	4-17	somatostatin	Homo sapiens	178-181
22495673-4	2012	Mutations to Asp 139 and Arg 140 also led to varying expression profiles with some mutants maintaining their affinity for SST.	Aspartic Acid	13-16	somatostatin	Homo sapiens	122-125
22685715-1	2012	Insect aspartate 1-decarboxylase (ADC) catalyzes the decarboxylation of aspartate to beta-alanine.	Aspartic Acid	7-16	glutamate decarboxylase like 1	Homo sapiens	34-37
22426135-10	2012	Alveolar A549 cells showed saturable ASP(+) uptake via two transporter sites with K(m) values of 12.5 +- 4.0 muM and 456.9 +- 164.5 muM, respectively.	Aspartic Acid	37-43	latexin	Homo sapiens	109-112
22426135-10	2012	Alveolar A549 cells showed saturable ASP(+) uptake via two transporter sites with K(m) values of 12.5 +- 4.0 muM and 456.9 +- 164.5 muM, respectively.	Aspartic Acid	37-43	latexin	Homo sapiens	132-135
22685715-3	2012	Substrate screening of Aedes aegypti ADC (AeADC), however, demonstrates that other than its activity to aspartate, the mosquito enzyme catalyzes the decarboxylation of cysteine sulfinic acid and cysteic acid as efficiently as those of mammalian CSADC under the same testing conditions.	Aspartic Acid	104-113	glutamate decarboxylase like 1	Homo sapiens	37-40
22498006-8	2012	Epitope mapping revealed that both Asp(75) and Thr(301) are major determinants in the binding of these nanobodies to TAFI.	Aspartic Acid	35-38	carboxypeptidase B2	Homo sapiens	117-121
22978107-8	2012	The activity of cysteine-containing aspartate-specific protease-3 (Caspase-3) was measured by spectrophotometry.	Aspartic Acid	36-45	caspase 3	Rattus norvegicus	67-76
22649225-3	2012	In particular, it has been postulated that proteolysis of Htt at the putative caspase-6 cleavage site (at amino acid Asp-586) plays a critical role in disease progression and pathogenesis.	Aspartic Acid	117-120	huntingtin	Mus musculus	58-61
22649225-3	2012	In particular, it has been postulated that proteolysis of Htt at the putative caspase-6 cleavage site (at amino acid Asp-586) plays a critical role in disease progression and pathogenesis.	Aspartic Acid	117-120	caspase 6	Mus musculus	78-87
22649225-9	2012	Importantly, we detected the presence of Htt fragments consistent with cleavage at amino acid Asp-586 of Htt in the BACHD Casp6(-/-) mouse, indicating that caspase-6 activity cannot fully account for the generation of the Htt 586 fragment in vivo.	Aspartic Acid	94-97	huntingtin	Mus musculus	41-44
22649225-9	2012	Importantly, we detected the presence of Htt fragments consistent with cleavage at amino acid Asp-586 of Htt in the BACHD Casp6(-/-) mouse, indicating that caspase-6 activity cannot fully account for the generation of the Htt 586 fragment in vivo.	Aspartic Acid	94-97	huntingtin	Mus musculus	105-108
22649225-9	2012	Importantly, we detected the presence of Htt fragments consistent with cleavage at amino acid Asp-586 of Htt in the BACHD Casp6(-/-) mouse, indicating that caspase-6 activity cannot fully account for the generation of the Htt 586 fragment in vivo.	Aspartic Acid	94-97	caspase 6	Mus musculus	122-127
22649225-9	2012	Importantly, we detected the presence of Htt fragments consistent with cleavage at amino acid Asp-586 of Htt in the BACHD Casp6(-/-) mouse, indicating that caspase-6 activity cannot fully account for the generation of the Htt 586 fragment in vivo.	Aspartic Acid	94-97	huntingtin	Mus musculus	105-108
22461626-3	2012	We investigated the contribution of the cluster of acidic residues in the distal C terminus of TRPA1 in these processes using mutagenesis, whole cell electrophysiology, and molecular dynamics simulations and found that the neutralization of four conserved residues, namely Glu(1077) and Asp(1080)-Asp(1082) in human TRPA1, had strong effects on the Ca(2+)- and voltage-dependent potentiation and/or inactivation of agonist-induced responses.	Aspartic Acid	287-290	transient receptor potential cation channel subfamily A member 1	Homo sapiens	95-100
22461626-3	2012	We investigated the contribution of the cluster of acidic residues in the distal C terminus of TRPA1 in these processes using mutagenesis, whole cell electrophysiology, and molecular dynamics simulations and found that the neutralization of four conserved residues, namely Glu(1077) and Asp(1080)-Asp(1082) in human TRPA1, had strong effects on the Ca(2+)- and voltage-dependent potentiation and/or inactivation of agonist-induced responses.	Aspartic Acid	287-290	transient receptor potential cation channel subfamily A member 1	Homo sapiens	316-321
22461626-3	2012	We investigated the contribution of the cluster of acidic residues in the distal C terminus of TRPA1 in these processes using mutagenesis, whole cell electrophysiology, and molecular dynamics simulations and found that the neutralization of four conserved residues, namely Glu(1077) and Asp(1080)-Asp(1082) in human TRPA1, had strong effects on the Ca(2+)- and voltage-dependent potentiation and/or inactivation of agonist-induced responses.	Aspartic Acid	297-300	transient receptor potential cation channel subfamily A member 1	Homo sapiens	95-100
22649803-19	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
22649803-19	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
22551424-1	2012	Binding isotope effects for l-aspartate reacting with the inactive K258A mutant of PLP-dependent aspartate aminotransferase to give a stable external aldimine intermediate are reported.	Aspartic Acid	28-39	proteolipid protein 1	Homo sapiens	83-86
22545704-1	2012	In this molecular docking study, the protonation states of the catalytic Asp dyad of the beta-secretase (BACE1) enzyme in the presence of eight chemically diverse inhibitors have been predicted.	Aspartic Acid	73-76	beta-secretase 1	Homo sapiens	105-110
22545704-6	2012	These results show that the knowledge of a single protonation state of the Asp dyad is not sufficient to search for the novel inhibitors of BACE1 and the most plausible state for each inhibitor must be determined prior to conducting in-silico screening.	Aspartic Acid	75-78	beta-secretase 1	Homo sapiens	140-145
22649804-19	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
22649804-19	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
22685715-11	2012	Our data clearly established the CSADC activity of mosquito and Drosophila ADC and revealed the primary role Q377 plays in aspartate selectivity in insect ADC.	Aspartic Acid	123-132	black	Drosophila melanogaster	75-78
22418432-4	2012	Here, using HPLC-electrospray tandem mass spectrometry, we mapped two cleavage sites at the C terminus of Cx50 after Glu-368 and Asp-379 and identified caspase-3 and caspase-1 as the responsible proteases, respectively.	Aspartic Acid	129-132	gap junction protein alpha 8	Gallus gallus	106-110
24281556-8	2012	However the opposite effect is found when only the integrin-binding domain of MFG-E8, the RGD (Arginine-Glycine-Aspartic acid) domain, was increased.	Aspartic Acid	112-125	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	78-84
22483750-4	2012	In epithelia, EAAT3 accomplishes transepithelial glutamate and aspartate transport.	Aspartic Acid	63-72	solute carrier family 1 member 1	Homo sapiens	14-19
22808515-3	2012	The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.	Aspartic Acid	140-143	C-X-C motif chemokine ligand 12	Homo sapiens	42-48
21542830-6	2012	KEY RESULTS: In EM4 cells expressing GFP-tagged human SERT (hSERT), MB concentration-dependently inhibited ASP(+) accumulation (IC(50) : 1.4 +- 0.3 microM).	Aspartic Acid	107-113	solute carrier family 6 member 4	Homo sapiens	54-58
21542830-6	2012	KEY RESULTS: In EM4 cells expressing GFP-tagged human SERT (hSERT), MB concentration-dependently inhibited ASP(+) accumulation (IC(50) : 1.4 +- 0.3 microM).	Aspartic Acid	107-113	solute carrier family 6 member 4	Homo sapiens	60-65
21542830-11	2012	Further experiments revealed that ASP(+) binding to cell surface hSERT was reduced after MB treatment.	Aspartic Acid	34-40	solute carrier family 6 member 4	Homo sapiens	65-70
22808515-3	2012	The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.	Aspartic Acid	140-143	homeobox A3	Homo sapiens	50-55
22808515-3	2012	The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.	Aspartic Acid	190-193	C-X-C motif chemokine ligand 12	Homo sapiens	42-48
22808515-3	2012	The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.	Aspartic Acid	190-193	C-X-C motif chemokine ligand 12	Homo sapiens	42-48
22450868-2	2012	We investigated whether endothelial nitric oxide synthase (eNOS) glutamate (Glu)298-aspartate (Asp) polymorphism may influence the vascular response to weight, as measured by BMI, in young, healthy individuals.	Aspartic Acid	84-93	nitric oxide synthase 3	Homo sapiens	24-57
22392649-6	2012	The transcellular transport kinetics were characterized with a K(m) of 69 +- 15 muM and a J(max) of 44 +- 3.1 pmol min(-1) cm(-2) for L-aspartate and a K(m) of 138 +- 49 muM and J(max) of 28 +- 3.1 pmol min(-1) cm(-2) for L-glutamate.	Aspartic Acid	134-145	latexin	Homo sapiens	170-173
22450868-8	2012	Higher FMD correlated with lower brachial baseline diameter (P &lt; 0.001), BMI (P = 0.03) and SBP (P = 0.03) in the Asp-carriers, but not in Glu-homozygotes.	Aspartic Acid	117-120	selenium binding protein 1	Homo sapiens	95-98
22127737-8	2012	Homology modeling identified a residue specific to ASPGB1, Phe(162), preceding the variable loop, whose side chain is located in proximity to the beta-carboxylate group of the product aspartate, and to Gly(246), a residue participating in an oxyanion hole which stabilizes a negative charge forming on the side chain oxygen of asparagine during catalysis.	Aspartic Acid	184-193	N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein	Arabidopsis thaliana	51-57
22385043-5	2012	To compare these findings to previous results, we quantified the effects of CCR antagonists on the RANTES-induced modifications of the spontaneous and the K+-evoked [3H]D-ASP release in the mouse cortex.	Aspartic Acid	171-174	chemokine (C-C motif) ligand 5	Mus musculus	99-105
22385043-6	2012	Here, CCR1 and CCR5, but not CCR3, antagonists prevented the RANTES-mediated [3H]D-ASP release, whereas RANTES-induced inhibition of the 12 mM K+-evoked [3H]D-ASP exocytosis was also antagonized by SB 328437.	Aspartic Acid	83-86	chemokine (C-C motif) receptor 1	Mus musculus	6-10
22385043-6	2012	Here, CCR1 and CCR5, but not CCR3, antagonists prevented the RANTES-mediated [3H]D-ASP release, whereas RANTES-induced inhibition of the 12 mM K+-evoked [3H]D-ASP exocytosis was also antagonized by SB 328437.	Aspartic Acid	83-86	chemokine (C-C motif) receptor 5	Mus musculus	15-19
22385043-6	2012	Here, CCR1 and CCR5, but not CCR3, antagonists prevented the RANTES-mediated [3H]D-ASP release, whereas RANTES-induced inhibition of the 12 mM K+-evoked [3H]D-ASP exocytosis was also antagonized by SB 328437.	Aspartic Acid	83-86	chemokine (C-C motif) ligand 5	Mus musculus	61-67
22385043-6	2012	Here, CCR1 and CCR5, but not CCR3, antagonists prevented the RANTES-mediated [3H]D-ASP release, whereas RANTES-induced inhibition of the 12 mM K+-evoked [3H]D-ASP exocytosis was also antagonized by SB 328437.	Aspartic Acid	159-162	chemokine (C-C motif) receptor 1	Mus musculus	6-10
22385043-6	2012	Here, CCR1 and CCR5, but not CCR3, antagonists prevented the RANTES-mediated [3H]D-ASP release, whereas RANTES-induced inhibition of the 12 mM K+-evoked [3H]D-ASP exocytosis was also antagonized by SB 328437.	Aspartic Acid	159-162	chemokine (C-C motif) receptor 5	Mus musculus	15-19
22385043-6	2012	Here, CCR1 and CCR5, but not CCR3, antagonists prevented the RANTES-mediated [3H]D-ASP release, whereas RANTES-induced inhibition of the 12 mM K+-evoked [3H]D-ASP exocytosis was also antagonized by SB 328437.	Aspartic Acid	159-162	chemokine (C-C motif) ligand 5	Mus musculus	104-110
23248692-3	2012	Sequencing analysis of voltage-gated sodium channel a1-subunit gene, SCN1A, confirmed a homozygous A to G change at nucleotide 5197 (c.5197A &gt; G) in exon 26 resulting in amino acid substitution of asparagines to aspartate at codon 1733 of sodium channel.	Aspartic Acid	215-224	sodium voltage-gated channel alpha subunit 1	Homo sapiens	69-74
22455451-3	2012	It is well-documented that the RGD (Arg-Gly-Asp) motif exhibits high binding affinity to integrin alpha(v)beta(3), which is abundantly expressed in cancer cells and specifically associated with angiogenesis on tumors.	Aspartic Acid	44-47	integrin subunit alpha V	Homo sapiens	89-113
22399291-3	2012	In this study, we examined the role of a highly conserved salt bridge residing at the extracellular loop of rat ASIC3 (Asp(107)-Arg(153)) and human ASIC1a (Asp(107)-Arg(160)) channels.	Aspartic Acid	119-122	acid sensing ion channel subunit 3	Rattus norvegicus	112-117
22326821-5	2012	Furthermore, the body weight, liver glycogen formation, antioxidant substance (GSH) and antioxidant enzyme (SOD and GPX) levels increased evidently in diabetic mice treated with both ASP and metformin.	Aspartic Acid	183-186	peroxiredoxin 6 pseudogene 2	Mus musculus	116-119
22330678-10	2012	We further demonstrate that the interaction of cathepsin Z with arginine-glycine-aspartic acid-binding integrins, specifically alphavbeta5, mediates the changes seen in adhesion of PDAC cells.	Aspartic Acid	81-94	cathepsin Z	Homo sapiens	47-58
22922100-8	2012	In addition, we show that deletion of the DDHD domain or introduction of point mutations at the conserved aspartate or histidine residues in the domain abolishes the phospholipase activity of KIAAO725p and PA-PLA1.	Aspartic Acid	106-115	DDHD domain containing 1	Homo sapiens	206-213
22386717-1	2012	Dihydrodipicolinate synthase is a key enzyme in the lysine biosynthesis pathway that catalyzes the condensation of pyruvate and aspartate semi-aldehyde.	Aspartic Acid	128-137	dihydrodipicolinate synthase	Escherichia coli	0-28
22429471-0	2012	Calcitonin gene-related peptide (CGRP) receptor antagonists: novel aspartates and succinates.	Aspartic Acid	67-77	calcitonin related polypeptide alpha	Homo sapiens	0-31
22429471-0	2012	Calcitonin gene-related peptide (CGRP) receptor antagonists: novel aspartates and succinates.	Aspartic Acid	67-77	calcitonin related polypeptide alpha	Homo sapiens	33-37
22429471-1	2012	Novel aspartate and succinate CGRP full antagonists were identified through core modification of a potent lead CGRP antagonist, BMS-694153.	Aspartic Acid	6-15	calcitonin related polypeptide alpha	Homo sapiens	111-115
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Aspartic Acid	138-147	argininosuccinate lyase	Homo sapiens	76-99
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Aspartic Acid	138-147	argininosuccinate lyase	Homo sapiens	101-104
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Aspartic Acid	138-147	glycine-N-acyltransferase	Homo sapiens	218-253
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Aspartic Acid	138-147	glycine-N-acyltransferase	Homo sapiens	255-258
22181833-3	2012	We have used four representative CR domains from the principal ligand-binding cluster of LRP to determine the energetics of interaction with well-defined small ligands that include methyl esters of lysine, arginine, histidine and aspartate, as well as N-terminally blocked lysine methyl ester.	Aspartic Acid	230-239	LDL receptor related protein 1	Homo sapiens	89-92
22531928-4	2012	Here, we evaluated hematopoietic activities of RUNX1 mutants with serine (S)/threonine (T) to alanine (A), aspartic acid (D), or glutamic acid (E) mutations at phosphorylation sites using primary culture systems.	Aspartic Acid	107-120	runt related transcription factor 1	Mus musculus	47-52
22327112-6	2012	Amino acids of HGPRT that are frequently involved in the binding of these compounds are Lys 66, Asp 74, Arg 77, Asp 81, Val 88, Tyr 182, Arg 192 and Arg 194.	Aspartic Acid	96-99	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	15-20
22327112-6	2012	Amino acids of HGPRT that are frequently involved in the binding of these compounds are Lys 66, Asp 74, Arg 77, Asp 81, Val 88, Tyr 182, Arg 192 and Arg 194.	Aspartic Acid	112-115	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	15-20
22334707-3	2012	Using structure-activity, homology modeling, molecular docking, and mutagenesis studies, we have located the substrate-binding site of sialin (SLC17A5), a lysosomal sialic acid exporter also recently implicated in exocytotic release of aspartate.	Aspartic Acid	236-245	solute carrier family 17 member 5	Homo sapiens	135-141
22095620-7	2012	In the beta1 integrin subunit, the corresponding residue is also Ala, whereas in both beta2 and beta7 integrin subunits, it is Asp.	Aspartic Acid	127-130	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	86-91
22357621-4	2012	In addition, analysis of a beta4 mutant containing a phosphomimicking aspartic acid residue at T1736 in the C-tail suggests that phosphorylation of this residue regulates the interaction with the plectin plakin domain.	Aspartic Acid	70-83	plectin	Homo sapiens	196-203
22298770-3	2012	This slow phase appears to be due to cis to trans prolyl isomerization of the Asp(29)-Pro(30) peptide bond in wild-type AHSP because it was absent when alphaCO was mixed with P30A and P30W AHSP, which are fixed in the trans conformation.	Aspartic Acid	78-81	alpha hemoglobin stabilizing protein	Homo sapiens	120-124
22298770-3	2012	This slow phase appears to be due to cis to trans prolyl isomerization of the Asp(29)-Pro(30) peptide bond in wild-type AHSP because it was absent when alphaCO was mixed with P30A and P30W AHSP, which are fixed in the trans conformation.	Aspartic Acid	78-81	alpha hemoglobin stabilizing protein	Homo sapiens	189-193
22278846-2	2012	The tip was modified with an antibody sensitive to the exposure of the arginine-glycine-aspartic acid (RGD) groups in FN.	Aspartic Acid	88-101	fibronectin 1	Homo sapiens	118-120
22311122-2	2012	Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)&gt; I(-) &gt; Br (-)&gt; Cl (-) &gt; F (-)&gt;&gt; aspartate (-)  glutamate (-)  gluconate(-).	Aspartic Acid	203-212	pannexin 1	Homo sapiens	31-36
22334707-3	2012	Using structure-activity, homology modeling, molecular docking, and mutagenesis studies, we have located the substrate-binding site of sialin (SLC17A5), a lysosomal sialic acid exporter also recently implicated in exocytotic release of aspartate.	Aspartic Acid	236-245	solute carrier family 17 member 5	Homo sapiens	143-150
22457888-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Aspartic Acid	135-138	integrin subunit alpha V	Homo sapiens	12-32
22461642-4	2012	Moreover, oridonin bound AML1-ETO, directing the enzymatic cleavage at aspartic acid 188 via caspase-3 to generate a truncated AML1-ETO (DeltaAML1-ETO) and preventing the protein from further proteolysis.	Aspartic Acid	71-84	RUNX family transcription factor 1	Homo sapiens	25-29
22461642-4	2012	Moreover, oridonin bound AML1-ETO, directing the enzymatic cleavage at aspartic acid 188 via caspase-3 to generate a truncated AML1-ETO (DeltaAML1-ETO) and preventing the protein from further proteolysis.	Aspartic Acid	71-84	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	30-33
22461642-4	2012	Moreover, oridonin bound AML1-ETO, directing the enzymatic cleavage at aspartic acid 188 via caspase-3 to generate a truncated AML1-ETO (DeltaAML1-ETO) and preventing the protein from further proteolysis.	Aspartic Acid	71-84	caspase 3	Homo sapiens	93-102
22457890-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Aspartic Acid	135-138	integrin subunit alpha V	Homo sapiens	12-32
22457887-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Aspartic Acid	135-138	integrin subunit alpha V	Homo sapiens	12-32
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Aspartic Acid	95-98	angiotensin converting enzyme 2	Homo sapiens	44-49
22385159-9	2012	Replacing Asp-653, Asp-706, and Asp-708 simultaneously with glycine in the C2 domain of PLC delta1 leads to a complete and selective loss of the stimulation and binding by PS.	Aspartic Acid	10-13	phospholipase C delta 1	Homo sapiens	88-98
22385159-9	2012	Replacing Asp-653, Asp-706, and Asp-708 simultaneously with glycine in the C2 domain of PLC delta1 leads to a complete and selective loss of the stimulation and binding by PS.	Aspartic Acid	19-22	phospholipase C delta 1	Homo sapiens	88-98
22385159-9	2012	Replacing Asp-653, Asp-706, and Asp-708 simultaneously with glycine in the C2 domain of PLC delta1 leads to a complete and selective loss of the stimulation and binding by PS.	Aspartic Acid	19-22	phospholipase C delta 1	Homo sapiens	88-98
22275364-2	2012	A conserved aspartate that forms a salt bridge with the ATP gamma-phosphate is found at the nucleotide-binding interface between RAD51 subunits of the NPF known as the ATP cap.	Aspartic Acid	12-21	RAD51 recombinase	Homo sapiens	129-134
22275364-7	2012	These studies suggest that the HsRAD51(Asp-316) salt bridge may function as a conformational sensor that enhances turnover at the expense of recombinase activity.	Aspartic Acid	39-42	RAD51 recombinase	Homo sapiens	31-38
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Aspartic Acid	95-98	angiotensin converting enzyme 2	Homo sapiens	163-168
22291010-7	2012	ASP(+), which was previously used to study catecholamine transporters, is 10 times less potent than APP(+) at inhibiting 5HT uptake and has minimal hSERT-mediated uptake.	Aspartic Acid	0-6	solute carrier family 6 member 4	Homo sapiens	148-153
22291010-8	2012	Furthermore, in hSERT-expressing oocytes voltage-clamped to -60 mV, APP(+) induced fluoxetine-sensitive hSERT-mediated inward currents, indicating APP(+) is a substrate, whereas ASP(+) induced hSERT-mediated outward currents and counteracted 5HT-induced hSERT currents, indicating ASP(+) possesses activity as an inhibitor.	Aspartic Acid	178-184	solute carrier family 6 member 4	Homo sapiens	16-21
22291010-8	2012	Furthermore, in hSERT-expressing oocytes voltage-clamped to -60 mV, APP(+) induced fluoxetine-sensitive hSERT-mediated inward currents, indicating APP(+) is a substrate, whereas ASP(+) induced hSERT-mediated outward currents and counteracted 5HT-induced hSERT currents, indicating ASP(+) possesses activity as an inhibitor.	Aspartic Acid	178-181	solute carrier family 6 member 4	Homo sapiens	16-21
22291010-9	2012	Extra-precise ligand receptor docking of APP(+) and ASP(+) in an hSERT homology model showed both ASP(+) and APP(+) docked favorably within the active region; accordingly, comparable concentrations are required to elicit their opposite electrophysiological responses.	Aspartic Acid	52-58	solute carrier family 6 member 4	Homo sapiens	65-70
22291010-9	2012	Extra-precise ligand receptor docking of APP(+) and ASP(+) in an hSERT homology model showed both ASP(+) and APP(+) docked favorably within the active region; accordingly, comparable concentrations are required to elicit their opposite electrophysiological responses.	Aspartic Acid	98-104	solute carrier family 6 member 4	Homo sapiens	65-70
21919991-0	2012	Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer"s disease.	Aspartic Acid	64-77	microtubule associated protein tau	Homo sapiens	49-52
22404924-1	2012	Previous studies have suggested that the aspartic acid residue (D) at the third position is critical in determining the voltage polarity of fast V(j)-gating of Cx50 channels.	Aspartic Acid	41-54	gap junction protein, alpha 8	Mus musculus	160-164
22132725-0	2012	An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling.	Aspartic Acid	3-12	solute carrier family 6 member 5	Homo sapiens	50-55
22132725-0	2012	An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling.	Aspartic Acid	3-12	solute carrier family 6 member 5	Homo sapiens	57-78
22422993-3	2012	Drugs patterned on the integrin ligand sequence Arg-Gly-Asp have a basic moiety that binds the alpha(IIb) subunit and a carboxyl group that coordinates the MIDAS Mg(2+) in the beta(3) subunits.	Aspartic Acid	56-59	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	176-183
22404924-0	2012	Aspartic acid residue D3 critically determines Cx50 gap junction channel transjunctional voltage-dependent gating and unitary conductance.	Aspartic Acid	0-13	gap junction protein, alpha 8	Mus musculus	47-51
21919991-1	2012	Pathological processing of tau protein during the formation and maturation of neurofibrillary tangles (NFTs) includes abnormal phosphorylation, conformational changes and truncation of the C-terminus at aspartic-acid(421)  (apoptotic product) and glutamic-acid(391)  residues.	Aspartic Acid	203-216	microtubule associated protein tau	Homo sapiens	27-30
22259020-4	2012	These studies showed that aspartate-8, histidine-11, glycine-6, proline-4, arginine-1, and proline-9, arranged in an order of importance, were critical, while threonine-2, valine-3, serine-5, and the previously assigned hydroxylation and arabinosylation residue proline-7 were trivial for the endogenous CLV3 function in SAM maintenance.	Aspartic Acid	26-35	CLAVATA3	Arabidopsis thaliana	304-308
21656378-8	2012	However, we found the significant association of RNASEL Asp541Glu polymorphism with sporadic PCa (Glu/Glu vs. Asp/Asp: OR 1.29, 95% CI: 1.04-1.59, P = 0.02; Glu/Asp vs. Asp/Asp: OR 1.24, 95% CI: 1.03-1.50, P = 0.03).	Aspartic Acid	56-59	ribonuclease L	Homo sapiens	49-55
21656378-8	2012	However, we found the significant association of RNASEL Asp541Glu polymorphism with sporadic PCa (Glu/Glu vs. Asp/Asp: OR 1.29, 95% CI: 1.04-1.59, P = 0.02; Glu/Asp vs. Asp/Asp: OR 1.24, 95% CI: 1.03-1.50, P = 0.03).	Aspartic Acid	110-113	ribonuclease L	Homo sapiens	49-55
21656378-8	2012	However, we found the significant association of RNASEL Asp541Glu polymorphism with sporadic PCa (Glu/Glu vs. Asp/Asp: OR 1.29, 95% CI: 1.04-1.59, P = 0.02; Glu/Asp vs. Asp/Asp: OR 1.24, 95% CI: 1.03-1.50, P = 0.03).	Aspartic Acid	110-113	ribonuclease L	Homo sapiens	49-55
21656378-8	2012	However, we found the significant association of RNASEL Asp541Glu polymorphism with sporadic PCa (Glu/Glu vs. Asp/Asp: OR 1.29, 95% CI: 1.04-1.59, P = 0.02; Glu/Asp vs. Asp/Asp: OR 1.24, 95% CI: 1.03-1.50, P = 0.03).	Aspartic Acid	110-113	ribonuclease L	Homo sapiens	49-55
21656378-8	2012	However, we found the significant association of RNASEL Asp541Glu polymorphism with sporadic PCa (Glu/Glu vs. Asp/Asp: OR 1.29, 95% CI: 1.04-1.59, P = 0.02; Glu/Asp vs. Asp/Asp: OR 1.24, 95% CI: 1.03-1.50, P = 0.03).	Aspartic Acid	110-113	ribonuclease L	Homo sapiens	49-55
21670956-8	2012	The Asp/Asp of XPG and Gln/Gln of XRCC1 in combination showed statistically increased risk of prostate cancer in cases (OR 3.29, 95% CI 1.09-10.16, P = 0.032).	Aspartic Acid	4-7	ERCC excision repair 5, endonuclease	Homo sapiens	15-18
21670956-8	2012	The Asp/Asp of XPG and Gln/Gln of XRCC1 in combination showed statistically increased risk of prostate cancer in cases (OR 3.29, 95% CI 1.09-10.16, P = 0.032).	Aspartic Acid	4-7	X-ray repair cross complementing 1	Homo sapiens	34-39
21670956-8	2012	The Asp/Asp of XPG and Gln/Gln of XRCC1 in combination showed statistically increased risk of prostate cancer in cases (OR 3.29, 95% CI 1.09-10.16, P = 0.032).	Aspartic Acid	8-11	ERCC excision repair 5, endonuclease	Homo sapiens	15-18
21670956-8	2012	The Asp/Asp of XPG and Gln/Gln of XRCC1 in combination showed statistically increased risk of prostate cancer in cases (OR 3.29, 95% CI 1.09-10.16, P = 0.032).	Aspartic Acid	8-11	X-ray repair cross complementing 1	Homo sapiens	34-39
22179618-7	2012	Five highly conserved residues, which form a two-carboxylate clamp that tightly interacts with the ultimate Asp-0 residue of the bound peptide, are also present in Tah1.	Aspartic Acid	108-111	Tah1p	Saccharomyces cerevisiae S288C	164-168
22586912-9	2012	The modeling analysis of the three dimensional structure elucidated that Lys-173 and Asp-202, which were oriented near the hydroxyl group of the substrate, were essential residues for the ProDH activity.	Aspartic Acid	85-88	proline dehydrogenase 1	Homo sapiens	188-193
22239987-2	2012	Data never presented before show that the oxidation rate of exogenous NADH supported by the malate-aspartate shuttle system (reconstituted in vitro with isolated liver mitochondria) is comparable to the rate obtained on activation of the cytosolic NADH/cytochrome c electron transport pathway.	Aspartic Acid	99-108	cytochrome c, somatic	Homo sapiens	253-265
22359779-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Mus musculus	121-132
22359781-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Mus musculus	121-132
22239987-4	2012	NADH oxidation induced by the malate-aspartate shuttle is inhibited by aminooxyacetate and by rotenone and/or antimycin A, two inhibitors of the respiratory chain, while the NADH/cytochrome c system remains insensitive to all of them.	Aspartic Acid	37-46	cytochrome c, somatic	Homo sapiens	179-191
22396417-5	2012	Overexpression of wild-type Tau or mutated forms in which these sites had been changed to either unphosphorylatable alanines or phosphomimetic aspartates inhibited mitochondrial movement in the neurite processes of PC12 cells as well as the axons of mouse brain cortical neurons.	Aspartic Acid	143-153	microtubule associated protein tau	Homo sapiens	28-31
22004688-4	2012	Intriguingly, PABP1 contains glutamate and aspartate methylations, modifications of unknown function in eukaryotes, as well as lysine and arginine methylations, and lysine acetylations.	Aspartic Acid	43-52	poly(A) binding protein cytoplasmic 1	Homo sapiens	14-19
22139979-2	2012	During a study involving more than 600 patients, we observed mainly G6PD A(-) (c.202G&gt;A, c.376A&gt;G; p.Val68Met, p.Asn126Asp), G6PD Mediterranean (Med) (c.563C&gt;T, p.Ser188Phe), and G6PD Betica (c.376A&gt;G, 542A&gt;T; p.126Asn&gt;Asp, 181Asp&gt;Val) with addition of a few rare ones.	Aspartic Acid	125-128	glucose-6-phosphate dehydrogenase	Homo sapiens	68-72
22130661-6	2012	We found that the extracellular membrane-proximal domain of HAb18G/CD147 (I-type domain) binds at the metal ion-dependent adhesion site in the betaA domain of the integrin beta1 subunit, and Asp(179) in the I-type domain of HAb18G/CD147 plays an important role in the interaction.	Aspartic Acid	191-194	basigin (Ok blood group)	Homo sapiens	67-72
22130661-6	2012	We found that the extracellular membrane-proximal domain of HAb18G/CD147 (I-type domain) binds at the metal ion-dependent adhesion site in the betaA domain of the integrin beta1 subunit, and Asp(179) in the I-type domain of HAb18G/CD147 plays an important role in the interaction.	Aspartic Acid	191-194	basigin (Ok blood group)	Homo sapiens	231-236
22179617-1	2012	Osteopontin (OPN) is a multifunctional phosphorylated protein containing the integrin binding sequence Arg-Gly-Asp through which it interacts with several integrin receptors, such as the alpha(V)beta(3)-integrin.	Aspartic Acid	111-114	secreted phosphoprotein 1	Homo sapiens	0-11
22179617-1	2012	Osteopontin (OPN) is a multifunctional phosphorylated protein containing the integrin binding sequence Arg-Gly-Asp through which it interacts with several integrin receptors, such as the alpha(V)beta(3)-integrin.	Aspartic Acid	111-114	secreted phosphoprotein 1	Homo sapiens	13-16
22010850-4	2012	In the present study, we show that the malate-aspartate NADH shuttle is impaired in Saccharomyces cerevisiae frataxin-deficient cells (Deltayfh1) due to decreased activity of cytosolic and mitochondrial isoforms of malate dehydrogenase and to complete inactivation of the mitochondrial aspartate aminotransferase (Aat1).	Aspartic Acid	46-55	aspartate transaminase AAT1	Saccharomyces cerevisiae S288C	314-318
22101068-4	2012	This mutation results in an aspartic acid to glycine substitution in the TUBA1 protein.	Aspartic Acid	28-41	tubulin, alpha 1A	Mus musculus	73-78
22061964-8	2012	Functionally, PP2A depletion increases NEDD9 mediated cell spreading and mutation of S369 in the serine-rich region of NEDD9 to aspartate mimics this effect.	Aspartic Acid	128-137	protein phosphatase 2 phosphatase activator	Homo sapiens	14-18
22061964-8	2012	Functionally, PP2A depletion increases NEDD9 mediated cell spreading and mutation of S369 in the serine-rich region of NEDD9 to aspartate mimics this effect.	Aspartic Acid	128-137	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	119-124
21310790-5	2012	A requirement for an intact Walker A box and the magnesium-co-ordinating aspartate of the classical Walker B box suggest that an initial ATP hydrolysis step is necessary for activation of both NOD1 and NOD2.	Aspartic Acid	73-82	nucleotide binding oligomerization domain containing 1	Homo sapiens	193-197
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	Aspartic Acid	129-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-28
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	Aspartic Acid	129-132	BCL2 apoptosis regulator	Homo sapiens	83-88
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	Aspartic Acid	129-132	BCL2 like 1	Homo sapiens	97-103
21310790-5	2012	A requirement for an intact Walker A box and the magnesium-co-ordinating aspartate of the classical Walker B box suggest that an initial ATP hydrolysis step is necessary for activation of both NOD1 and NOD2.	Aspartic Acid	73-82	nucleotide binding oligomerization domain containing 2	Homo sapiens	202-206
22239117-7	2012	An additional set of modifications, which exchanges aspartate for glutamate, results in an overall lowering of stability of the ABC triple helix yet shows further improvement in the system"s specificity.	Aspartic Acid	52-61	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	128-131
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Aspartic Acid	176-179	interleukin 24	Homo sapiens	64-69
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Aspartic Acid	176-179	interleukin 24	Homo sapiens	92-97
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Aspartic Acid	176-179	interleukin 24	Homo sapiens	98-103
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Aspartic Acid	176-179	interleukin 24	Homo sapiens	233-238
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Aspartic Acid	176-179	interleukin 24	Homo sapiens	98-103
22101235-7	2012	Intriguingly, CYP3A5, a polymorphically expressed human liver CYP3A4 isoform (containing Asp-478) is ubiquitinated but not degraded to a greater extent than CYP3A4 in HepG2 cells.	Aspartic Acid	89-92	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	14-20
22101235-7	2012	Intriguingly, CYP3A5, a polymorphically expressed human liver CYP3A4 isoform (containing Asp-478) is ubiquitinated but not degraded to a greater extent than CYP3A4 in HepG2 cells.	Aspartic Acid	89-92	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-68
22101235-10	2012	Through proteomic analyses, we identify (i) 12 additional phosphorylation sites that may be involved in CHIP-CYP3A4 interactions and (ii) 8 previously unidentified CYP3A4 ubiquitination sites within spatially associated clusters of Asp/Glu and phosphorylatable Ser/Thr residues that may serve to engage each E2-E3 complex.	Aspartic Acid	232-235	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	164-170
22232659-6	2012	This aspartate lies in one of the two PQ-loop motifs shared by cystinosin with a set of eukaryotic membrane proteins of unknown function and is conserved in about half of them, thus suggesting that other PQ-loop proteins may translocate protons.	Aspartic Acid	5-14	cystinosin, lysosomal cystine transporter	Homo sapiens	63-73
22284751-3	2012	METHODS: A dHuEPO-expressing vector under the control of the goat beta-casein promoter, which produced a dimer of human EPO molecules linked by a 2-amino acid peptide linker (Asp-Ile), was constructed and injected into 1-cell fertilized embryos by microinjection.	Aspartic Acid	175-178	erythropoietin	Homo sapiens	14-17
22101235-6	2012	We document herein that of these, Ser-478 plays a pivotal role in UBC7/gp78-mediated CYP3A4 ubiquitination, which is accelerated and enhanced on its mutation to the phosphomimetic Asp residue but attenuated on its Ala mutation.	Aspartic Acid	180-183	ubiquitin conjugating enzyme E2 G2	Homo sapiens	66-70
22101235-6	2012	We document herein that of these, Ser-478 plays a pivotal role in UBC7/gp78-mediated CYP3A4 ubiquitination, which is accelerated and enhanced on its mutation to the phosphomimetic Asp residue but attenuated on its Ala mutation.	Aspartic Acid	180-183	autocrine motility factor receptor	Homo sapiens	71-75
22101235-6	2012	We document herein that of these, Ser-478 plays a pivotal role in UBC7/gp78-mediated CYP3A4 ubiquitination, which is accelerated and enhanced on its mutation to the phosphomimetic Asp residue but attenuated on its Ala mutation.	Aspartic Acid	180-183	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	85-91
20921968-3	2012	Both tropisetron and ondansetron inhibited ASP(+) uptake in OCT1-overexpressing HEK293 cells.	Aspartic Acid	43-49	solute carrier family 22 member 1	Homo sapiens	60-64
22307598-3	2012	Our results demonstrate that ATP8A2 forms a phosphoenzyme intermediate at the conserved aspartate (Asp(416)) in the P-type ATPase signature sequence and exists in E(1)P and E(2)P forms similar to the archetypical P-type ATPases.	Aspartic Acid	88-97	ATPase phospholipid transporting 8A2	Homo sapiens	29-35
22307598-3	2012	Our results demonstrate that ATP8A2 forms a phosphoenzyme intermediate at the conserved aspartate (Asp(416)) in the P-type ATPase signature sequence and exists in E(1)P and E(2)P forms similar to the archetypical P-type ATPases.	Aspartic Acid	99-102	ATPase phospholipid transporting 8A2	Homo sapiens	29-35
22143383-1	2012	A new label-free method for the detection of apoptosis was proposed based on colorimetric assay of caspase-3 activity using an unlabeled Asp-Glu-Val-Asp (DEVD)-containing peptide substrate and unmodified gold nanoparticles (AuNPs).	Aspartic Acid	137-140	caspase 3	Homo sapiens	99-108
22143383-1	2012	A new label-free method for the detection of apoptosis was proposed based on colorimetric assay of caspase-3 activity using an unlabeled Asp-Glu-Val-Asp (DEVD)-containing peptide substrate and unmodified gold nanoparticles (AuNPs).	Aspartic Acid	149-152	caspase 3	Homo sapiens	99-108
22294086-11	2012	We used a bi-functional caspase-3 substrate containing a DEVD (Asp-Glu-Val-Asp) caspase-3 recognition subunit and a DNA-binding dye.	Aspartic Acid	63-66	caspase 3	Homo sapiens	24-33
20641959-20	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Aspartic Acid	44-47	vitronectin	Homo sapiens	130-141
20641959-20	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Aspartic Acid	44-47	fibrinogen beta chain	Homo sapiens	143-153
22132761-3	2012	Here we report a novel assay for Asp isomerization by isotopic labeling with (18)O via a two-step process: the isoAsp peptide is first specifically methylated by protein isoaspartate methyltransferase (PIMT, EC 2.1.1.77) to the corresponding methyl ester, which is subsequently hydrolyzed in (18)O-water to regenerate isoAsp.	Aspartic Acid	33-36	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	202-206
22191331-2	2012	The arylsulfanyl pyrazolone (ASP) scaffold was one of the active scaffolds identified in a cell-based high throughput screening assay targeting mutant Cu/Zn superoxide dismutase 1 (SOD1) induced toxicity and aggregation as a marker for ALS.	Aspartic Acid	29-32	superoxide dismutase 1, soluble	Mus musculus	181-185
22294086-11	2012	We used a bi-functional caspase-3 substrate containing a DEVD (Asp-Glu-Val-Asp) caspase-3 recognition subunit and a DNA-binding dye.	Aspartic Acid	63-66	caspase 3	Homo sapiens	80-89
22787594-1	2012	In particular, glia may facilitate the establishment of epilepsy by impaired removal of glutamate from synapses or by releasing inflammatory cytokines and excitatory neurotransmitters, such as interleukin-1beta or, respectively, glutamate, aspartate and D-serine.	Aspartic Acid	240-249	interleukin 1 beta	Homo sapiens	193-210
22198771-7	2012	An NMR model of a substituted-ZiaA(N)-Cu(I)-Atx1 heterodimer has been generated making it possible to visualize a juxtaposition of residues surrounding the ZiaA(N) zinc site, including Asp(18), which normally repulse Atx1.	Aspartic Acid	185-188	antioxidant 1 copper chaperone	Homo sapiens	44-48
23289226-3	2012	The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene.	Aspartic Acid	78-81	interferon gamma	Homo sapiens	118-134
21718305-5	2012	KEY RESULTS: A network of polar interactions stabilized by a direct ionic bond between DF 2156A and Lys(99) on CXCR1 and the non-conserved residue Asp(293) on CXCR2 are the key determinants of DF 2156A binding.	Aspartic Acid	147-150	C-X-C motif chemokine receptor 2	Homo sapiens	159-164
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Aspartic Acid	62-65	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Aspartic Acid	149-152	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Aspartic Acid	149-152	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Aspartic Acid	149-152	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Aspartic Acid	149-152	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22994751-4	2012	RESULTS: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04].	Aspartic Acid	149-152	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
22170151-3	2012	Mutational analyses of ATG7 revealed that both mutant ATG7DeltaFAP lacking the FAP motif and ATG7FAPtoDDD, in which the Phe15-Ala16-Pro17 sequence was changed to Asp-Asp-Asp, could not complement defects in endogenous ATG12-conjugation and LC3-lipidation when expressed in Atg7-deficient mouse embryonic fibroblasts (MEFs).	Aspartic Acid	162-165	autophagy related 7	Mus musculus	23-27
22759973-5	2012	Angiotensin II (AII) via stimulation of Ca(2+)/calmodulin increased ASP(+)-uptake.	Aspartic Acid	68-74	arginase type II	Mus musculus	0-14
22175728-0	2012	Partial blocking of mouse DSPP processing by substitution of Gly(451)-Asp(452) bond suggests the presence of secondary cleavage site(s).	Aspartic Acid	70-73	dentin sialophosphoprotein	Mus musculus	26-30
22175728-2	2012	In the proteolytic processing of mouse DSPP, the peptide bond at Gly(451)-Asp(452) has been shown to be cleaved by bone morphogenetic protein 1 (BMP1)/Tolloid-like metalloproteinases.	Aspartic Acid	74-77	dentin sialophosphoprotein	Mus musculus	39-43
22175728-2	2012	In the proteolytic processing of mouse DSPP, the peptide bond at Gly(451)-Asp(452) has been shown to be cleaved by bone morphogenetic protein 1 (BMP1)/Tolloid-like metalloproteinases.	Aspartic Acid	74-77	bone morphogenetic protein 1	Mus musculus	115-143
22175728-2	2012	In the proteolytic processing of mouse DSPP, the peptide bond at Gly(451)-Asp(452) has been shown to be cleaved by bone morphogenetic protein 1 (BMP1)/Tolloid-like metalloproteinases.	Aspartic Acid	74-77	bone morphogenetic protein 1	Mus musculus	145-149
22175728-9	2012	Taken together, we concluded that in addition to the peptide bond Gly(451)-Asp(452), there must be a cryptic cleavage site or sites close to Asp(452) in the mouse DSPP that can be cleaved by BMP1.	Aspartic Acid	75-78	dentin sialophosphoprotein	Mus musculus	163-167
22175728-9	2012	Taken together, we concluded that in addition to the peptide bond Gly(451)-Asp(452), there must be a cryptic cleavage site or sites close to Asp(452) in the mouse DSPP that can be cleaved by BMP1.	Aspartic Acid	141-144	dentin sialophosphoprotein	Mus musculus	163-167
22272823-3	2012	Peptide RGD sequence Arg-Gly-Asp targeted and combined to integrin alphavbeta3 which has been overexpressed on tumor endothelial cells and many different tumor cellsis a robust site for tumor angiogenesis molecular imaging and targeted therapy.	Aspartic Acid	29-32	integrin subunit alpha V	Homo sapiens	58-78
22664242-2	2012	Of these, the radiolabeled Arg-Gly- Asp (RGD) peptide has been focused because it has high affinity and selectivity for integrin alpha(v)beta3.	Aspartic Acid	36-39	integrin subunit alpha V	Homo sapiens	120-142
22759973-5	2012	Angiotensin II (AII) via stimulation of Ca(2+)/calmodulin increased ASP(+)-uptake.	Aspartic Acid	68-74	arginase type II	Mus musculus	16-19
22759973-5	2012	Angiotensin II (AII) via stimulation of Ca(2+)/calmodulin increased ASP(+)-uptake.	Aspartic Acid	68-74	calmodulin 2	Mus musculus	47-57
22642608-2	2012	The presence of the Asp allele in Asp358Ala of IL6R has been linked with insulin resistance and weight gain.	Aspartic Acid	20-23	interleukin 6 receptor	Homo sapiens	47-51
22642608-2	2012	The presence of the Asp allele in Asp358Ala of IL6R has been linked with insulin resistance and weight gain.	Aspartic Acid	20-23	insulin	Homo sapiens	73-80
22642608-11	2012	CONCLUSIONS: T1D in Chilean women appears to be associated with the presence of the Asp allele in IL6R.	Aspartic Acid	84-87	interleukin 6 receptor	Homo sapiens	98-102
23038158-11	2012	CONCLUSIONS: These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.	Aspartic Acid	49-52	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	44-48
22143007-5	2012	The exchange of metabolites between cytosol and mitochondrial matrix is mediated via a set of mitochondrial carriers, including the aspartate-glutamate carrier (aralar1), alpha- ketoglutarate carrier (OGC), ATP/ADP carrier (AAC), glutamate carrier (GC1), dicarboxylate carrier (DIC) and citrate/isocitrate carrier (CIC).	Aspartic Acid	132-141	solute carrier family 25 member 22	Homo sapiens	249-252
21972205-2	2012	Based on the antibody-protein adhesive force maps and phase imaging, it was found that the nanomorphology of the triblock copolymer is conducive to the exposure of the arginine-glycine-aspartic acid (RGD) groups in Fn.	Aspartic Acid	185-198	fibronectin 1	Homo sapiens	215-217
23038158-11	2012	CONCLUSIONS: These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.	Aspartic Acid	49-52	tumor protein p53	Homo sapiens	167-170
23038158-0	2012	The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.	Aspartic Acid	9-12	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	4-8
23038158-11	2012	CONCLUSIONS: These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.	Aspartic Acid	53-56	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	44-48
23038158-0	2012	The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.	Aspartic Acid	9-12	tumor protein p53	Homo sapiens	115-118
23038158-0	2012	The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.	Aspartic Acid	13-16	tumor protein p53	Homo sapiens	115-118
21900421-4	2012	The model predicts that UL98 residues D254, E278 and K280 represent the critical aspartic acid, glutamic acid and lysine active-site residues, respectively, while R164 and S252 correspond to residues proposed to bind the 5" phosphate of the DNA substrate.	Aspartic Acid	81-94	deoxyribonuclease	Human betaherpesvirus 5	24-28
23038158-11	2012	CONCLUSIONS: These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.	Aspartic Acid	53-56	tumor protein p53	Homo sapiens	167-170
23038158-0	2012	The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.	Aspartic Acid	13-16	tumor protein p53	Homo sapiens	115-118
23038158-0	2012	The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.	Aspartic Acid	13-16	tumor protein p53	Homo sapiens	115-118
23038158-11	2012	CONCLUSIONS: These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.	Aspartic Acid	53-56	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	44-48
23038158-9	2012	However, a higher risk of p53 mutation was found in participants with the APE1 Asp/Asp genotype than in those with the APE1-Glu allele (OR, 2.15; 95% CI, 1.19-3.87; P = 0.011).	Aspartic Acid	79-82	tumor protein p53	Homo sapiens	26-29
23038158-11	2012	CONCLUSIONS: These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.	Aspartic Acid	53-56	tumor protein p53	Homo sapiens	167-170
23038158-9	2012	However, a higher risk of p53 mutation was found in participants with the APE1 Asp/Asp genotype than in those with the APE1-Glu allele (OR, 2.15; 95% CI, 1.19-3.87; P = 0.011).	Aspartic Acid	79-82	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	74-78
23038158-9	2012	However, a higher risk of p53 mutation was found in participants with the APE1 Asp/Asp genotype than in those with the APE1-Glu allele (OR, 2.15; 95% CI, 1.19-3.87; P = 0.011).	Aspartic Acid	83-86	tumor protein p53	Homo sapiens	26-29
23038158-11	2012	CONCLUSIONS: These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.	Aspartic Acid	53-56	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	44-48
23038158-9	2012	However, a higher risk of p53 mutation was found in participants with the APE1 Asp/Asp genotype than in those with the APE1-Glu allele (OR, 2.15; 95% CI, 1.19-3.87; P = 0.011).	Aspartic Acid	83-86	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	74-78
23038158-10	2012	The risk of p53 mutation was also higher in participants with APE1 Asp/Asp plus hOGG1-Cys than in those with APE1-Glu plus hOGG1 Ser/Ser (OR, 3.72; 95% CI, 1.33-10.40; P = 0.012).	Aspartic Acid	67-70	tumor protein p53	Homo sapiens	12-15
23038158-11	2012	CONCLUSIONS: These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.	Aspartic Acid	53-56	tumor protein p53	Homo sapiens	167-170
23038158-10	2012	The risk of p53 mutation was also higher in participants with APE1 Asp/Asp plus hOGG1-Cys than in those with APE1-Glu plus hOGG1 Ser/Ser (OR, 3.72; 95% CI, 1.33-10.40; P = 0.012).	Aspartic Acid	67-70	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	62-66
21932369-8	2012	Immunoscreening of a brain cDNA library identified the antigen as DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 (Ddx54), a member of the DEAD box family of RNA helicases involved in RNA metabolism, transcription, and translation.	Aspartic Acid	72-75	DEAD-box helicase 54	Rattus norvegicus	109-114
23038158-10	2012	The risk of p53 mutation was also higher in participants with APE1 Asp/Asp plus hOGG1-Cys than in those with APE1-Glu plus hOGG1 Ser/Ser (OR, 3.72; 95% CI, 1.33-10.40; P = 0.012).	Aspartic Acid	71-74	tumor protein p53	Homo sapiens	12-15
23038158-10	2012	The risk of p53 mutation was also higher in participants with APE1 Asp/Asp plus hOGG1-Cys than in those with APE1-Glu plus hOGG1 Ser/Ser (OR, 3.72; 95% CI, 1.33-10.40; P = 0.012).	Aspartic Acid	71-74	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	62-66
23226286-8	2012	Finally, it is shown that sea bass and avian IL-1beta are specifically cleaved by caspase-1 at different but phylogenetically conserved aspartates, distinct from the cleavage site of mammalian IL-1beta.	Aspartic Acid	136-146	interleukin 1 beta	Homo sapiens	45-53
23430852-1	2012	Citrin plays a role in the transfer of NADH-reducing equivalent from cytosol to mitochondria as part of the malate-aspartate shuttle in liver.	Aspartic Acid	115-124	solute carrier family 25 member 13	Homo sapiens	0-6
22665973-1	2012	PURPOSE: Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a member of a new family of transcriptional modulators.	Aspartic Acid	81-94	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	9-15
22665973-1	2012	PURPOSE: Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a member of a new family of transcriptional modulators.	Aspartic Acid	81-94	CREB binding protein	Mus musculus	17-20
22665973-1	2012	PURPOSE: Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a member of a new family of transcriptional modulators.	Aspartic Acid	81-94	E1A binding protein p300	Mus musculus	21-25
24349908-2	2012	Residues more susceptible to MALDI-ISD, namely Xxx-Asp/Asn and Gly-Xxx, were identified from the discontinuous intense peak of c"-ions originating from specific cleavage at N-Calpha bonds of the backbone of equine cytochrome c.	Aspartic Acid	51-54	cytochrome c, somatic	Equus caballus	214-226
24349908-5	2012	The MALDI-ISD spectrum of equine cytochrome c gave not only intense N-terminal side c"-ions originating from N-Calpha bond cleavage at Xxx-Asp/Asn and Gly-Xxx residues, but also C-terminal side complement z"-ions originating from the same cleavage sites.	Aspartic Acid	139-142	cytochrome c, somatic	Equus caballus	33-45
21965537-6	2012	In overlay assay, the Asp mutation at S11 (S11D) completely abolished the self-interaction of rP20 and significantly inhibited the interaction with both the WT and S11A rP20.	Aspartic Acid	22-25	heat shock protein family B (small) member 6	Rattus norvegicus	94-98
21965537-6	2012	In overlay assay, the Asp mutation at S11 (S11D) completely abolished the self-interaction of rP20 and significantly inhibited the interaction with both the WT and S11A rP20.	Aspartic Acid	22-25	heat shock protein family B (small) member 6	Rattus norvegicus	169-173
23226286-8	2012	Finally, it is shown that sea bass and avian IL-1beta are specifically cleaved by caspase-1 at different but phylogenetically conserved aspartates, distinct from the cleavage site of mammalian IL-1beta.	Aspartic Acid	136-146	caspase 1	Homo sapiens	82-91
23185472-1	2012	For mammalian TRPM8, the amino acid residues asparagine-799 and aspartate-802 are essential for the stimulation of the channel by the synthetic agonist icilin.	Aspartic Acid	64-73	transient receptor potential cation channel subfamily M member 8	Homo sapiens	14-19
22761916-3	2012	Replacement of the phenylalanine at the +2 consensus position in the signal peptide of a Tat-specific reporter protein (TorA-MalE) by aspartate blocked export of the corresponding TorA(D(+2))-MalE precursor, indicating that this mutation prevents a productive binding of the TorA(D(+2)) signal peptide to the Tat translocase.	Aspartic Acid	134-143	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	309-312
23133647-3	2012	This is in contrast to mutations within a heparin-binding TB domain (TB5), which is downstream of the arg-gly-asp cell adhesion domain, which can cause Weill-Marchesani syndrome (WMS) or Acromicric (AD) and Geleophysic Dysplasias (GD).	Aspartic Acid	110-113	transforming growth factor beta regulator 1	Homo sapiens	69-72
22844406-4	2012	Since aspartic acid and glutamic acid residues are acceptors of the ADP ribose moiety transferred by PARP-1, deletion of the evolutionarily conserved C-terminal Glu-rich tail of HOXB7 dramatically attenuates ADP-ribosylation of HOXB7 by PARP-1.	Aspartic Acid	6-19	poly(ADP-ribose) polymerase 1	Homo sapiens	101-107
22844406-4	2012	Since aspartic acid and glutamic acid residues are acceptors of the ADP ribose moiety transferred by PARP-1, deletion of the evolutionarily conserved C-terminal Glu-rich tail of HOXB7 dramatically attenuates ADP-ribosylation of HOXB7 by PARP-1.	Aspartic Acid	6-19	homeobox B7	Homo sapiens	178-183
23300743-1	2012	The monoclonal antibody 2A4 binds an epitope derived from a cleavage site of serum amyloid protein A (sAA) containing a -Glu-Asp- amino acid pairing.	Aspartic Acid	125-128	serum amyloid A1 cluster	Homo sapiens	77-100
23300743-1	2012	The monoclonal antibody 2A4 binds an epitope derived from a cleavage site of serum amyloid protein A (sAA) containing a -Glu-Asp- amino acid pairing.	Aspartic Acid	125-128	serum amyloid A1 cluster	Homo sapiens	102-105
22737219-2	2012	Methyltransferases (MTases) of the DNMT2 family have been shown to have a dual substrate specificity acting on DNA as well as on three specific tRNAs (tRNA(Asp), tRNA(Val), tRNA(Gly)).	Aspartic Acid	156-159	tRNA aspartic acid methyltransferase 1	Homo sapiens	35-40
22761916-3	2012	Replacement of the phenylalanine at the +2 consensus position in the signal peptide of a Tat-specific reporter protein (TorA-MalE) by aspartate blocked export of the corresponding TorA(D(+2))-MalE precursor, indicating that this mutation prevents a productive binding of the TorA(D(+2)) signal peptide to the Tat translocase.	Aspartic Acid	134-143	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	89-92
22675558-10	2012	Further structure-function investigations that employed site-directed mutagenesis and circular dichroism spectroscopy identified the importance of Val-126, Glu-222, Asp-306, Phe-486 and Phe-488 in keeping the enzymatic activity of CYP2D49 toward bufuralol as well as the importance of Asp-306, Phe-486 and Phe-488 in maintaining the conformation of CYP2D49 protein.	Aspartic Acid	285-288	cytochrome P450 family 2 subfamily D member 6	Gallus gallus	231-238
22574206-10	2012	Interestingly, when subjected to transport function analysis of higher concentration of esteone-3-sulfate (50 microM) that corresponds to the low affinity binding site of OATP1B1, mutants of Phe73, Glu74, and Gly76 all showed a transport function that is comparable to that of the wild-type, suggesting these amino acids may have less impact on the low affinity component of esteone-3-sulfate within OATP1B1, while Asp 70 seems to be involved in the interaction of both sites.	Aspartic Acid	415-418	solute carrier organic anion transporter family member 1B1	Homo sapiens	171-178
22045810-3	2011	Here, we demonstrate that knockdown of PTP1B or expression of a PTP1B trapping aspartic acid-to-alanine substitution (D/A) mutant delayed ligand-induced degradation of the Met and EGF RTKs.	Aspartic Acid	79-92	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	64-69
22558217-7	2012	A newly observed feature of NS3/4A was a high frequency of either Asp or Glu at both P5 and P6 positions in a subset of the most efficient NS3/4A substrates.	Aspartic Acid	66-69	KRAS proto-oncogene, GTPase	Homo sapiens	28-31
22558217-7	2012	A newly observed feature of NS3/4A was a high frequency of either Asp or Glu at both P5 and P6 positions in a subset of the most efficient NS3/4A substrates.	Aspartic Acid	66-69	KRAS proto-oncogene, GTPase	Homo sapiens	139-142
22442717-10	2012	Altered FAAH(-/-) mitochondrial malate dehydrogenase (MDH2) acetylation, which can affect the malate aspartate shuttle, was consistent with our observation of a 25% decrease in fed malate and aspartate levels.	Aspartic Acid	101-110	fatty acid amide hydrolase	Mus musculus	8-12
22442717-10	2012	Altered FAAH(-/-) mitochondrial malate dehydrogenase (MDH2) acetylation, which can affect the malate aspartate shuttle, was consistent with our observation of a 25% decrease in fed malate and aspartate levels.	Aspartic Acid	101-110	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	54-58
22403649-12	2012	Our results provide evidence that a subset of conserved Glu, Asp and Tyr residues in both subunits are essential for channel activity of the heteromeric insect Or-Orco complex.	Aspartic Acid	61-64	Odorant receptor co-receptor	Drosophila melanogaster	163-167
23213356-5	2012	Using wild-type Ataxin-1 and Ser776 mutants to a phosphomimetic aspartate and to alanine, we show that U2AF65 binds Ataxin-1 in a Ser776 phosphorylation independent manner whereas 14-3-3 interacts with phosphorylated wild-type Ataxin-1 but not with the mutants.	Aspartic Acid	64-73	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	103-109
21990355-8	2011	The functional consequence of this interaction on DAT activity was further examined with real-time monitoring of transport function using a fluorescent substrate of DAT, 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP+).	Aspartic Acid	218-222	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	50-53
21990355-8	2011	The functional consequence of this interaction on DAT activity was further examined with real-time monitoring of transport function using a fluorescent substrate of DAT, 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP+).	Aspartic Acid	218-222	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	165-168
22006923-7	2011	Mutagenesis of TrbI showed that the conserved Lys-93 and Asp-155 are essential, whereas mutagenesis of Ser-52, the putative catalytic serine did not influence circularization.	Aspartic Acid	57-60	TrbI	Neisseria gonorrhoeae	15-19
21984827-5	2011	In the Glt(Ph) structure, a conserved aspartate residue (Asp-390) is located adjacent to a conserved tyrosine residue, previously shown to be a molecular determinant of ion selectivity in the brain glutamate transporter GLT-1.	Aspartic Acid	38-47	solute carrier family 1 member 2	Homo sapiens	220-225
22032417-2	2011	CaM contains 9 methionine (Met), 1 histidine (His), 17 aspartic acid (Asp), and 23 glutamine acid (Glu) residues, all of which can potentially react with platinum compounds; thus, one-third of the CaM sequence is a possible binding target of platinum anticancer drugs, which represents a major challenge for identification of specific platinum modification sites.	Aspartic Acid	55-68	calmodulin 1	Homo sapiens	0-3
22032417-2	2011	CaM contains 9 methionine (Met), 1 histidine (His), 17 aspartic acid (Asp), and 23 glutamine acid (Glu) residues, all of which can potentially react with platinum compounds; thus, one-third of the CaM sequence is a possible binding target of platinum anticancer drugs, which represents a major challenge for identification of specific platinum modification sites.	Aspartic Acid	70-73	calmodulin 1	Homo sapiens	0-3
22032417-6	2011	At a high molar ratio of cisplatin:CaM (8:1), up to 10 platinum(II) bind to Met, Asp, and Glu residues.	Aspartic Acid	81-84	calmodulin 1	Homo sapiens	35-38
22095502-2	2011	In particular: pSer and pThr (like pTyr) may transfer phosphate groups to C-terminal carboxyl anions and to the carboxyl anion side chains of Asp and Glu, and characteristic nucleophilic/cleavage reactions accompany or follow these rearrangements.	Aspartic Acid	142-145	parathyroid hormone 1 receptor	Homo sapiens	24-28
22095715-0	2011	Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.	Aspartic Acid	141-150	integrin subunit alpha M	Homo sapiens	100-105
22095715-0	2011	Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.	Aspartic Acid	141-150	integrin subunit beta 2	Homo sapiens	106-110
22095715-6	2011	Favored binding of the Ca(2+) ion at MIDAS is caused by the unusual symmetric bidentate ligation of a Fab-derived ligand Asp to a heptacoordinated MIDAS Ca(2+) ion.	Aspartic Acid	121-124	FA complementation group B	Homo sapiens	102-105
21965679-6	2011	Val-2 of IL-36Ra lies 9 amino acids N-terminal to an A-X-Asp motif conserved in all IL-1 family members.	Aspartic Acid	57-60	interleukin 36 receptor antagonist	Homo sapiens	9-16
21984827-5	2011	In the Glt(Ph) structure, a conserved aspartate residue (Asp-390) is located adjacent to a conserved tyrosine residue, previously shown to be a molecular determinant of ion selectivity in the brain glutamate transporter GLT-1.	Aspartic Acid	57-60	solute carrier family 1 member 2	Homo sapiens	220-225
21984827-6	2011	In this study, we characterize mutants of Asp-440 of the neuronal transporter EAAC1, which is the counterpart of Asp-390 of Glt(Ph).	Aspartic Acid	42-45	solute carrier family 1 member 1	Homo sapiens	78-83
21984827-6	2011	In this study, we characterize mutants of Asp-440 of the neuronal transporter EAAC1, which is the counterpart of Asp-390 of Glt(Ph).	Aspartic Acid	113-116	solute carrier family 1 member 1	Homo sapiens	78-83
21898593-2	2011	We have previously shown that the impaired Arg-Gly-Asp (RGD) sequence of osteopontin inhibits renal crystal formation by using OPN-transgenic mice and OPN-knockout (OPN-KO) mice.	Aspartic Acid	51-54	secreted phosphoprotein 1	Mus musculus	73-84
21812758-5	2011	Mutation of Galpha(q) at amino acids Lys(52), Thr(186) or Asp(205), residues that are predicted to interact with nucleotide phosphates or catalytic Mg(2+), dramatically reduced lysoPLD activity.	Aspartic Acid	58-61	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	177-184
21801267-6	2011	Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population.	Aspartic Acid	88-91	insulin receptor substrate 2	Homo sapiens	25-30
21801267-6	2011	Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population.	Aspartic Acid	88-91	interleukin 6	Homo sapiens	50-54
21801267-6	2011	Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population.	Aspartic Acid	88-91	insulin receptor substrate 2	Homo sapiens	71-76
21801267-7	2011	Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant.	Aspartic Acid	103-106	interleukin 6	Homo sapiens	47-51
21801267-7	2011	Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant.	Aspartic Acid	103-106	insulin receptor substrate 2	Homo sapiens	86-91
21553234-5	2011	Functionally, overexpression of LAPTM4A significantly decreased ASP(+) uptake in HEK293 cells stably transfected with hOCT2, suggesting a negative regulation of hOCT2-mediated transport.	Aspartic Acid	64-70	lysosomal protein transmembrane 4 alpha	Homo sapiens	32-39
21553234-5	2011	Functionally, overexpression of LAPTM4A significantly decreased ASP(+) uptake in HEK293 cells stably transfected with hOCT2, suggesting a negative regulation of hOCT2-mediated transport.	Aspartic Acid	64-70	solute carrier family 22 member 2	Homo sapiens	118-123
21681855-3	2011	In a four-generation Chinese family with congenital nuclear pulverulent and posterior polar cataracts, we detected a heterozygous c.5G&gt;A transition in the second exon of GJA3, resulting in the substitution of a highly conserved glycine with aspartic acid (p.G2D) at the N-terminus of the connexin46 (Cx46) protein.	Aspartic Acid	244-257	gap junction protein alpha 3	Homo sapiens	173-177
21608011-0	2011	Deficiency of the mitochondrial transporter of aspartate/glutamate aralar/AGC1 causes hypomyelination and neuronal defects unrelated to myelin deficits in mouse brain.	Aspartic Acid	47-56	aggrecan	Mus musculus	74-78
21956413-7	2011	INTERVENTIONS: Glucose-induced insulin response was assessed on three occasions after 4 h saline (low insulin/sham) or isoglycemic-hyperinsulinemic (high insulin) clamps with or without intralipid and heparin infusion, using B28 Asp-insulin that could be distinguished from endogenous insulin immunologically.	Aspartic Acid	229-232	insulin	Homo sapiens	31-38
22095898-2	2011	METHODS: We constructed a surface-modified adenoviral vector with RGD (Arg-Gly-Asp) sequences encoding human X-linked inhibitor of apoptosis and hepatocyte growth factor (RGD-Adv-hHGF-hXIAP).	Aspartic Acid	79-82	X-linked inhibitor of apoptosis	Homo sapiens	109-140
22043013-0	2011	Paxillin associates with the microtubule cytoskeleton and the immunological synapse of CTL through its leucine-aspartic acid domains and contributes to microtubule organizing center reorientation.	Aspartic Acid	111-124	paxillin	Homo sapiens	0-8
22043013-2	2011	We mapped the region of paxillin that associates with both the MTOC and SMAC to the leucine-aspartic acid (LD) domains and showed that a protein segment containing LD2-4 was sufficient for MTOC and SMAC recruitment.	Aspartic Acid	92-105	paxillin	Homo sapiens	24-32
21374701-5	2011	Furthermore, the concentration and (13) C labelling of aspartate in cortex were reduced in DLST+/- mice.	Aspartic Acid	55-64	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	Mus musculus	91-95
21608011-1	2011	The aralar/AGC1 knockout (KO) mouse shows a drastic decrease in brain aspartate and N-acetylaspartate levels and global hypomyelination, which are attributed to the lack of neuron-produced NAA used by oligodendrocytes as precursor of myelin lipid synthesis.	Aspartic Acid	70-79	aggrecan	Mus musculus	11-15
22065779-6	2011	The appearance of asymmetrically enriched malate and aspartate indicated high rates of anaplerotic pyruvate carboxylase activity and incomplete equilibration with fumarate.	Aspartic Acid	53-62	pyruvate carboxylase	Mus musculus	99-119
21976483-2	2011	Because the STN7 protein kinase of Arabidopsis is known to be phosphorylated at four serine-threonine residues, we have changed these residues by site-directed mutagenesis to alanine (STN7-4A) or aspartic acid (STN7-4D) to assess the role of these phosphorylation events.	Aspartic Acid	196-209	Serine/Threonine kinase domain protein	Arabidopsis thaliana	12-16
21976665-6	2011	Further, key acidic residues Glu(6), Asp(8), and Glu(16), believed critical for Pyrin/Pyrin domain interaction, are important for inflammasome inhibition.	Aspartic Acid	37-40	MEFV innate immuity regulator, pyrin	Homo sapiens	80-85
21976665-6	2011	Further, key acidic residues Glu(6), Asp(8), and Glu(16), believed critical for Pyrin/Pyrin domain interaction, are important for inflammasome inhibition.	Aspartic Acid	37-40	MEFV innate immuity regulator, pyrin	Homo sapiens	86-91
21840384-9	2011	Air followed by Asp exposure tended to induce IL-8 expression whereas IL-8 production tended to increase after FA and Asp exposure compared to FA and air exposure.	Aspartic Acid	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
22037576-2	2011	Recently we have demonstrated that a local force applied via Arg-Gly-Asp (RGD) peptides coated magnetic beads to mouse embryonic stem (ES) cells increases cell spreading and cell stiffness and decreases Oct3/4 (Pou5f1) gene expression.	Aspartic Acid	69-72	POU domain, class 5, transcription factor 1	Mus musculus	203-209
22037576-2	2011	Recently we have demonstrated that a local force applied via Arg-Gly-Asp (RGD) peptides coated magnetic beads to mouse embryonic stem (ES) cells increases cell spreading and cell stiffness and decreases Oct3/4 (Pou5f1) gene expression.	Aspartic Acid	69-72	POU domain, class 5, transcription factor 1	Mus musculus	211-217
21937424-4	2011	The TREX1 proteins containing R114H and the insertion mutations aspartate at position 201 (D201ins) and alanine at position 124 (A124ins), found in compound heterozygous AGS with R114H, were prepared and the DNA degradation activities were tested.	Aspartic Acid	64-73	three prime repair exonuclease 1	Homo sapiens	4-9
21840384-9	2011	Air followed by Asp exposure tended to induce IL-8 expression whereas IL-8 production tended to increase after FA and Asp exposure compared to FA and air exposure.	Aspartic Acid	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
21945805-7	2011	Mutation of Ser415 to the phosphomimetic residues Glu (S415E) or Asp (S415D) interfered with direct binding of the PC cytoplasmic tail to ezrin in vitro.	Aspartic Acid	65-68	podocalyxin-like	Rattus norvegicus	115-117
22091477-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Mus musculus	121-132
21560118-7	2011	Replacement of this aspartic acid residue with alanine disrupts TM5 self-association in detergent micelles and bacterial cell membranes.	Aspartic Acid	20-33	tropomyosin 3	Homo sapiens	64-67
21703367-3	2011	It is shown that protonation of the pyridine ring of PLP in aspartate aminotransferase (AspAT) is achieved by (i) an intermolecular OHN hydrogen bond with an aspartate residue, assisted by the imidazole group of a histidine side chain and (ii) a local polarity as found for related model systems in a polar organic solvent exhibiting a dielectric constant of about 30.	Aspartic Acid	60-69	pyridoxal phosphatase	Homo sapiens	53-56
21975069-3	2011	A homology model of hMCHR1 suggests that these compounds interact with Asn 294 and Asp 123 in the binding site of hMCHR1 to enhance binding affinity.	Aspartic Acid	83-86	melanin concentrating hormone receptor 1	Homo sapiens	20-26
21975069-3	2011	A homology model of hMCHR1 suggests that these compounds interact with Asn 294 and Asp 123 in the binding site of hMCHR1 to enhance binding affinity.	Aspartic Acid	83-86	melanin concentrating hormone receptor 1	Homo sapiens	114-120
21826518-7	2011	To probe this issue we performed a Cu(2+) titration study for K28C-EDTA GB1 monitored by 2D (15)N-(1)H solution-state NMR, which revealed that while for Cu(2+):protein molar ratios of &lt;= 1.0 Cu(2+) binds primarily to the high-affinity EDTA tag, as anticipated, at even slightly super-stoichiometric ratios the Cu(2+) ions can also associate with side-chains of aspartate and glutamate residues.	Aspartic Acid	364-373	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	72-75
22446538-3	2011	In a recent study,we found that the inhibitory avoidance (IA) task, a hippocampus-dependent contextual fear learning paradigm, drives GluR1-containing AMPARs into CA3-CA1 synapses of the dorsal hippocampus.We expressed mutated membrane-proxymal region (14 amino acids) of the GluR1-cytoplasmic tail (serines mutated to phospho-mimicking aspartates:MPR-DD) in the dorsal hippocampus to block the synaptic delivery of endogenous AMPARs.	Aspartic Acid	337-347	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	134-139
22446538-3	2011	In a recent study,we found that the inhibitory avoidance (IA) task, a hippocampus-dependent contextual fear learning paradigm, drives GluR1-containing AMPARs into CA3-CA1 synapses of the dorsal hippocampus.We expressed mutated membrane-proxymal region (14 amino acids) of the GluR1-cytoplasmic tail (serines mutated to phospho-mimicking aspartates:MPR-DD) in the dorsal hippocampus to block the synaptic delivery of endogenous AMPARs.	Aspartic Acid	337-347	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	151-157
22446538-3	2011	In a recent study,we found that the inhibitory avoidance (IA) task, a hippocampus-dependent contextual fear learning paradigm, drives GluR1-containing AMPARs into CA3-CA1 synapses of the dorsal hippocampus.We expressed mutated membrane-proxymal region (14 amino acids) of the GluR1-cytoplasmic tail (serines mutated to phospho-mimicking aspartates:MPR-DD) in the dorsal hippocampus to block the synaptic delivery of endogenous AMPARs.	Aspartic Acid	337-347	carbonic anhydrase 3	Homo sapiens	163-170
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Aspartic Acid	121-124	fibronectin 1	Mus musculus	80-91
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Aspartic Acid	121-124	ral guanine nucleotide dissociation stimulator	Mus musculus	130-134
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Aspartic Acid	121-124	transforming growth factor, beta 1	Mus musculus	212-221
22313298-5	2011	Binding interaction as determined by the docking study revealed that these inhibitors interact at active site (ASP 335 &amp; TYR 383) of sEH enzyme.	Aspartic Acid	111-114	epoxide hydrolase 2	Homo sapiens	137-140
21741329-6	2011	It was shown that the hydrogen bonds of Ser60 and Val214 to the carboxyl group of Asp are important components during substrate recognition by PIMT.	Aspartic Acid	82-85	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	143-147
21880742-6	2011	Curiously, two key residues (Asp-327 and Phe-330) in the GABA(A)R alpha2 and alpha3 binding sites on gephyrin also contribute to GlyR beta subunit-E domain interactions.	Aspartic Acid	29-32	gephyrin	Homo sapiens	101-109
21225462-2	2011	Through PCR-RFLP methods and DNA sequencing, an allelic variant corresponding to the A G mutations and Aspartic (Asp) to Glycine (Gly) amino acid replacement at positions 526745 in the exon 25 of bovine CACNA2D1 gene could be detected.	Aspartic Acid	103-106	calcium voltage-gated channel auxiliary subunit alpha2delta 1	Bos taurus	203-211
22037414-9	2011	A CYLD substitution mutation at Asp 215 that cannot be cleaved by caspase 8 switches cell survival to necrotic cell death in response to TNF.	Aspartic Acid	32-35	CYLD lysine 63 deubiquitinase	Homo sapiens	2-6
22037414-9	2011	A CYLD substitution mutation at Asp 215 that cannot be cleaved by caspase 8 switches cell survival to necrotic cell death in response to TNF.	Aspartic Acid	32-35	caspase 8	Homo sapiens	66-75
22037414-9	2011	A CYLD substitution mutation at Asp 215 that cannot be cleaved by caspase 8 switches cell survival to necrotic cell death in response to TNF.	Aspartic Acid	32-35	tumor necrosis factor	Homo sapiens	137-140
21824916-6	2011	Cells expressing PNKP with alanine or aspartic acid at serines 114 and 126 were modestly radiosensitive and IR enhanced the association of PNKP with XRCC4 and DNA ligase IV; however, this interaction was not affected by mutation of PNKP phosphorylation sites.	Aspartic Acid	38-51	polynucleotide kinase 3'-phosphatase	Homo sapiens	17-21
21824916-6	2011	Cells expressing PNKP with alanine or aspartic acid at serines 114 and 126 were modestly radiosensitive and IR enhanced the association of PNKP with XRCC4 and DNA ligase IV; however, this interaction was not affected by mutation of PNKP phosphorylation sites.	Aspartic Acid	38-51	X-ray repair cross complementing 4	Homo sapiens	149-154
21824916-6	2011	Cells expressing PNKP with alanine or aspartic acid at serines 114 and 126 were modestly radiosensitive and IR enhanced the association of PNKP with XRCC4 and DNA ligase IV; however, this interaction was not affected by mutation of PNKP phosphorylation sites.	Aspartic Acid	38-51	DNA ligase 4	Homo sapiens	159-172
22058000-2	2011	We investigated a possible association between the CAT exon 9  (Asp-389) gene and vitiligo susceptibility in the Turkish population.	Aspartic Acid	64-67	catalase	Homo sapiens	51-54
22058000-5	2011	The CAT exon 9 (Asp-389) genotype and allele frequencies of vitiligo patients did  not differ significantly from those of healthy controls.	Aspartic Acid	16-19	catalase	Homo sapiens	4-7
22035583-6	2011	Alanine substitution of two amino acids, aspartic acid 127 and histidine 196 within the 5"-nucleotidase signature sequence, leads to reduced AMP or ADP hydrolysis but does not affect the binding of these substrates.	Aspartic Acid	41-54	5'-nucleotidase ecto	Homo sapiens	88-103
21890632-7	2011	The typical substrate motif for the catalytic domain of Ptprz was deduced to be Glu/Asp-Glu/Asp-Glu/Asp-Xaa-Ile/Val-Tyr(P)-Xaa (Xaa is not an acidic residue).	Aspartic Acid	84-87	protein tyrosine phosphatase receptor type Z1	Homo sapiens	56-61
21890632-7	2011	The typical substrate motif for the catalytic domain of Ptprz was deduced to be Glu/Asp-Glu/Asp-Glu/Asp-Xaa-Ile/Val-Tyr(P)-Xaa (Xaa is not an acidic residue).	Aspartic Acid	92-95	protein tyrosine phosphatase receptor type Z1	Homo sapiens	56-61
21880742-6	2011	Curiously, two key residues (Asp-327 and Phe-330) in the GABA(A)R alpha2 and alpha3 binding sites on gephyrin also contribute to GlyR beta subunit-E domain interactions.	Aspartic Acid	29-32	glycine receptor beta	Homo sapiens	129-138
22020278-6	2011	Here we identify aspartate 112 as a crucial component of the selectivity filter of H(V)1.	Aspartic Acid	17-26	hydrogen voltage gated channel 1	Homo sapiens	83-88
21878618-3	2011	Conserved amino acids Asp-102 and Arg-106 of FAHD1 were found important for its catalytic activity, and Mg(2+) was required for maximal enzyme activity.	Aspartic Acid	22-25	fumarylacetoacetate hydrolase domain containing 1	Homo sapiens	45-50
21870003-4	2011	Both aspartic acid and glutamic acid replaces PBI from the coordination sphere of Co(II)-PBI complex resulting appearance of strong fluorescence signal for the released free PBI.	Aspartic Acid	5-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
21987804-8	2011	Interestingly, mutation to aspartate (G98D) or proline (G98P) caused constitutive channel activation in a STIM1-independent manner.	Aspartic Acid	27-36	stromal interaction molecule 1	Homo sapiens	106-111
21870003-5	2011	The signal response is very fast and the interaction of both the AspA and GluA with the Co(II) is strong enough as evident from their displacement equilibrium constant values, viz.	Aspartic Acid	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
21888914-5	2011	Much to our surprise, in the AMSH219(E280A) structure, the catalytic zinc was still held in place, by the compensatory effect of an aspartate from a nearby loop moving into a position where it could coordinate with the zinc, once again suggesting the plasticity of AMSH.	Aspartic Acid	132-141	STAM binding protein	Homo sapiens	29-33
21880731-6	2011	The binding specificity was determined primarily through the recognition of arginine 2 and lysine 4 of the unH3 by conserved aspartic acids of PHD1 and of threonine 6 of the unH3 by a conserved asparagine.	Aspartic Acid	125-139	Phd1p	Saccharomyces cerevisiae S288C	143-147
21676488-6	2011	Over-expression of Asp2 led to changes in aspartate content and aspartate-derived amino acids.	Aspartic Acid	42-51	aspartate aminotransferase 2	Arabidopsis thaliana	19-23
21828245-7	2011	Pathway analysis identified these genes to be involved in Rac/RhoA signaling, Wnt/B-catenin signaling and alanine/aspartate metabolism.	Aspartic Acid	114-123	ras homolog family member A	Homo sapiens	62-66
21676488-6	2011	Over-expression of Asp2 led to changes in aspartate content and aspartate-derived amino acids.	Aspartic Acid	64-73	aspartate aminotransferase 2	Arabidopsis thaliana	19-23
21864556-5	2011	As for APE1 Asp148Glu, heterozygous subjects showed significantly higher urinary 8-OHdG concentrations than did those homozygous for Asp/Asp.	Aspartic Acid	12-15	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	7-11
21882820-1	2011	Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline-aspartate (WPD) loop in catalysis.	Aspartic Acid	145-154	6-pyruvoyltetrahydropterin synthase	Homo sapiens	0-29
21882820-1	2011	Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline-aspartate (WPD) loop in catalysis.	Aspartic Acid	145-154	6-pyruvoyltetrahydropterin synthase	Homo sapiens	31-35
21899370-1	2011	The endocannabinoid hydrolyzing enzyme FAAH uses a nonclassical catalytic triad (namely, Ser-Ser-Lys instead of Ser-Asp-His) to cleave its endogenous substrates.	Aspartic Acid	116-119	fatty acid amide hydrolase	Homo sapiens	39-43
21846128-9	2011	In particular, an ionizable active site lysine and aspartate are present in all SDH homologues.	Aspartic Acid	51-60	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	80-83
21978545-1	2011	The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the beta subunit of G-proteins (Gbeta).	Aspartic Acid	76-85	receptor for activated C kinase 1	Homo sapiens	4-37
21877723-4	2011	Here, we found that the aspartyl (Asp) residue at position 4 of betaB2-crystallin in the lenses of elderly human individuals undergoes a significant degree of inversion and isomerization to the biologically uncommon residue D-beta-Asp.	Aspartic Acid	34-37	crystallin beta B2	Homo sapiens	64-81
21892826-1	2011	We previously identified Asp(340) in transmembrane segment 7 (TM7) as a key determinant of substrate affinity in Hxt7, a high-affinity facilitative glucose transporter of Saccharomyces cerevisiae.	Aspartic Acid	25-28	hexose transporter HXT7	Saccharomyces cerevisiae S288C	113-117
21892826-11	2011	A working homology model of Hxt7 indicated that Gln(209) and Thr(213) face the central cavity and that Thr(213) is located within van der Waals distance of Asp(340) (TM7).	Aspartic Acid	156-159	hexose transporter HXT7	Saccharomyces cerevisiae S288C	28-32
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Aspartic Acid	267-270	TANK binding kinase 1	Homo sapiens	92-95
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Aspartic Acid	267-270	TANK binding kinase 1	Homo sapiens	176-179
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Aspartic Acid	267-270	TANK binding kinase 1	Homo sapiens	176-179
21978545-1	2011	The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the beta subunit of G-proteins (Gbeta).	Aspartic Acid	76-85	receptor for activated C kinase 1	Homo sapiens	39-44
21816131-7	2011	Plasma levels of C3 fell, whereas concentrations of C3adesArg (alias acylation stimulating protein; ASP), produced by serum carboxypeptidase N-mediated desargination of C3a, increased in nonfasted high fat-fed apoE(-/-)/CD55(-/-) mice, indicating complement activation.	Aspartic Acid	100-103	apolipoprotein E	Mus musculus	210-214
21933962-1	2011	The structural and functional conversion of the nonselective NaK channel to a K(+) selective channel (NaK2K) allows us to identify two key residues, Tyr and Asp in the filter sequence of TVGYGD, that participate in interactions central to stabilizing the K(+) channel selectivity filter.	Aspartic Acid	157-160	TANK binding kinase 1	Homo sapiens	61-64
21816131-7	2011	Plasma levels of C3 fell, whereas concentrations of C3adesArg (alias acylation stimulating protein; ASP), produced by serum carboxypeptidase N-mediated desargination of C3a, increased in nonfasted high fat-fed apoE(-/-)/CD55(-/-) mice, indicating complement activation.	Aspartic Acid	100-103	CD55 molecule, decay accelerating factor for complement	Mus musculus	220-224
21620795-1	2011	The D-pathway in A-type cytochrome c oxidases conducts protons from a conserved aspartate on the negatively charged N-side of the membrane to a conserved glutamic acid at about the middle of the membrane dielectric.	Aspartic Acid	80-89	cytochrome c, somatic	Homo sapiens	24-36
21757705-3	2011	Using mutant cycle analysis and unnatural residue mutagenesis, including backbone mutagenesis of the peptide bond of the vicinal disulfide, we have established the presence of a network of hydrogen bonds that extends from that peptide NH, across a beta turn to another backbone hydrogen bond, and then across the subunit interface to the side chain of a functionally important Asp residue in the non-alpha subunit.	Aspartic Acid	377-380	amyloid beta precursor protein	Homo sapiens	246-252
21689736-15	2011	Although the G. aurantiaca also has NadA and NadB to synthesize a quinolinic acid (a precursor of NAD(+)) via the aspartate pathway, the high activity of the G. aurantiaca IDO flanking the kynU gene suggests its IDO has a function similar to eukaryotic enzymes.	Aspartic Acid	114-123	indoleamine 2,3-dioxygenase 1	Homo sapiens	172-175
21781115-1	2011	Sialin, the protein coded by SLC17A5, is responsible for membrane potential (Deltapsi)-driven aspartate and glutamate transport into synaptic vesicles in addition to H+/sialic acid co-transport in lysosomes.	Aspartic Acid	94-103	solute carrier family 17 member 5	Homo sapiens	0-6
21781115-1	2011	Sialin, the protein coded by SLC17A5, is responsible for membrane potential (Deltapsi)-driven aspartate and glutamate transport into synaptic vesicles in addition to H+/sialic acid co-transport in lysosomes.	Aspartic Acid	94-103	solute carrier family 17 member 5	Homo sapiens	29-36
21781115-4	2011	Proteoliposomes containing purified heterologously expressed human sialin exhibited both Deltapsi-driven aspartate and glutamate transport activity and H+/sialic acid co-transport activity.	Aspartic Acid	105-114	solute carrier family 17 member 5	Homo sapiens	67-73
21781115-6	2011	In contrast, SLC17A5 protein harboring the mutations associated with infantile sialic acid storage disease, H183R and Delta268SSLRN272 still showed normal levels of Deltapsi-driven aspartate and glutamate transport even though H+/sialic acid co-transport activity was absent.	Aspartic Acid	181-190	solute carrier family 17 member 5	Homo sapiens	13-20
21515380-1	2011	Enteropeptidase (synonym: enterokinase, EC 3.4.21.9) is a heterodimeric serine protease of the intestinal brush border that activates trypsinogen by highly specific cleavage of the trypsinogen activation peptide following the sequence (Asp)(4)-Lys.	Aspartic Acid	236-239	transmembrane serine protease 15	Homo sapiens	0-15
21515380-5	2011	In this study we have improved the efficiency of fusion proteins cleavage by enteropeptidase by substitution of the Lys residue by Arg in specific cleavage sequence (Asp)(4)-Lys.	Aspartic Acid	166-169	transmembrane serine protease 15	Homo sapiens	77-92
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Aspartic Acid	180-183	transmembrane serine protease 15	Bos taurus	94-109
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Aspartic Acid	180-183	thioredoxin	Bos taurus	142-145
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Aspartic Acid	180-183	fibroblast growth factor 2	Bos taurus	160-165
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Aspartic Acid	244-247	transmembrane serine protease 15	Bos taurus	94-109
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Aspartic Acid	244-247	thioredoxin	Bos taurus	142-145
21840993-4	2011	We found that acidic residues (Asp-83 and Asp-84) in G1 of GSNL-1 are important for its Ca(2+) activation.	Aspartic Acid	31-34	Gelsolin-like protein 1	Caenorhabditis elegans	59-65
21840993-4	2011	We found that acidic residues (Asp-83 and Asp-84) in G1 of GSNL-1 are important for its Ca(2+) activation.	Aspartic Acid	42-45	Gelsolin-like protein 1	Caenorhabditis elegans	59-65
20641531-7	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Aspartic Acid	44-47	vitronectin	Homo sapiens	130-141
20641531-7	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Aspartic Acid	44-47	fibrinogen beta chain	Homo sapiens	143-153
21708296-4	2011	Mutations of the aspartate 455 and serine 456 residues within the TPP binding domain of the human HACL1 did not affect the targeting upon expression in transfected CHO cells, although enzyme activity was abolished.	Aspartic Acid	17-26	2-hydroxyacyl-CoA lyase 1	Homo sapiens	98-103
21598311-1	2011	Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate.	Aspartic Acid	57-66	aspartoacylase	Rattus norvegicus	0-14
21598311-1	2011	Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate.	Aspartic Acid	57-66	aspartoacylase	Rattus norvegicus	16-20
21769085-12	2011	Mutation of S(1356)S(1360)S(1364) in SCC cells to non-phosphorylatable alanines stabilized HD-like structures and substantially reduced migration, while mutation into phosphorylation mimicking aspartate reduced HD-like structures but had no effect on migration, suggesting that serine phosphorylation function is releasing anchorage rather than promoting migration.	Aspartic Acid	193-202	serpin family B member 3	Homo sapiens	37-40
21832054-0	2011	Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.	Aspartic Acid	31-34	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	21-27
21832054-2	2011	To verify this finding in an animal model, we inserted three stop codons at the corresponding Asp-1904 in the murine CaV1.2 gene.	Aspartic Acid	94-97	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	117-123
21808053-2	2011	TREX1 mutations at amino acid positions Asp-18 and Asp-200 in familial chilblain lupus and Aicardi-Goutieres syndrome elicit dominant immune dysfunction phenotypes.	Aspartic Acid	40-43	three prime repair exonuclease 1	Homo sapiens	0-5
21808053-2	2011	TREX1 mutations at amino acid positions Asp-18 and Asp-200 in familial chilblain lupus and Aicardi-Goutieres syndrome elicit dominant immune dysfunction phenotypes.	Aspartic Acid	51-54	three prime repair exonuclease 1	Homo sapiens	0-5
21757689-5	2011	GroES Ile-25, Val-26, and Leu-27, residues on the GroEL-GroES interface, were substituted with Asp on different groES modules of groES(7).	Aspartic Acid	95-98	heat shock protein family E (Hsp10) member 1	Homo sapiens	0-5
21872570-3	2011	Interestingly, the Kir channels do not have this exact interaction, but instead have a Glu-Arg salt bridge where the Glu is in the same position but the Arg is one position N-terminal compared to the Asp in KcsA.	Aspartic Acid	200-203	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	19-22
21757689-5	2011	GroES Ile-25, Val-26, and Leu-27, residues on the GroEL-GroES interface, were substituted with Asp on different groES modules of groES(7).	Aspartic Acid	95-98	heat shock protein family E (Hsp10) member 1	Homo sapiens	112-117
21757689-5	2011	GroES Ile-25, Val-26, and Leu-27, residues on the GroEL-GroES interface, were substituted with Asp on different groES modules of groES(7).	Aspartic Acid	95-98	heat shock protein family E (Hsp10) member 1	Homo sapiens	129-134
21757728-6	2011	Stable expression of aspartic acid phosphomimetic (S490D) results in centrosomal localization of occludin and increases cell numbers.	Aspartic Acid	21-34	occludin	Canis lupus familiaris	97-105
21415861-5	2011	However, unlike bacterial rhomboids, which employ a diad-based mechanism of catalysis, Parl appears to use a conserved mitochondrial rhomboid-specific Asp residue on TMH-5 in a triad-based mechanism of catalysis.	Aspartic Acid	151-154	presenilin associated rhomboid like	Homo sapiens	87-91
21600870-7	2011	Mutations of Asn227 Ala, Asp, Arg; Ile233 Ala; Leu243 Ala; Glu247 Asp; Glu248 Gln yielded significant reduction in NHE1 activity.	Aspartic Acid	25-28	solute carrier family 9 member A1	Homo sapiens	115-119
21668429-12	2011	Molecular modelling showed that glycine 170 is located on the dimer interface of UROD, in a loop containing residues 167-172 that are critical for optimal enzymatic activity and that the carboxyl side chain from aspartic acid is predicted to cause negative interactions between the protein and the substrate.	Aspartic Acid	212-225	uroporphyrinogen decarboxylase	Homo sapiens	81-85
21871131-2	2011	ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a unique 40-amino acid serine and aspartic acid rich (SAR) subdomain, whereas, ESE-1"s nuclear transcriptional property is required to maintain the transformed phenotype of MCF7, ZR-75-1 and T47D breast cancer cells.	Aspartic Acid	149-162	E74 like ETS transcription factor 3	Homo sapiens	0-5
21526341-1	2011	A number of phosphomimicking mutants (replacement of Ser/Thr residues by Asp) of human small heat shock protein HspB8 were obtained and phosphorylation of the wild type HspB8 and its mutants by ERK1 kinase was analyzed in vitro.	Aspartic Acid	73-76	heat shock protein family B (small) member 8	Homo sapiens	112-117
21832969-4	2011	These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT&gt;GAG; Asp&gt;Glu) and 420 (ACG&gt;AAG; Thr&gt;Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases.	Aspartic Acid	104-107	D-box binding PAR bZIP transcription factor	Homo sapiens	67-70
21832969-8	2011	Although the DBP position 416 alone was not found to be significantly associated with IBD, the haplotype DBP_2, consisting of 416 Asp and 420 Lys, was more frequent in the non-IBD population, particularly notably when compared with the UC group (Odds ratio, 4.390).	Aspartic Acid	130-133	D-box binding PAR bZIP transcription factor	Homo sapiens	105-108
22007496-8	2011	The mutation of nt14319T --&gt; C, which not being reported previously, locate in the region of ND6 subunit, causing amino acid change (asparagine --&gt; aspartic acid).	Aspartic Acid	154-167	mitochondrially encoded NADH dehydrogenase 6	Homo sapiens	96-99
21667093-5	2011	A conserved aspartic acid in RecB nuclease superfamily Motif II (D89) is also essential for SIRV2gp19 activity and mutation to alanine (D89A) abolishes activity.	Aspartic Acid	12-25	Dna2/Cas4 domain-containing protein	Sulfolobus islandicus rod-shaped virus 2	92-101
22184996-2	2011	The frequency of chromosome aberrations was found to be significantly lower in the carriers of the genotype hOGG1 326 Ser/Ser (versus the variant Ser/Cys), APE1 148 Asp/Asp (versus Val/Ala and Ala/Ala).	Aspartic Acid	165-168	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	156-160
21768284-3	2011	The pneumococcal genome encodes two conserved proteins of an as yet unknown function, SP1298 and SP2205, classified as DHH (Asp-His-His) subfamily 1 proteins.	Aspartic Acid	124-127	desert hedgehog	Mus musculus	119-122
21725014-3	2011	l-Aspartate-beta-semialdehyde is a central intermediate in different biosynthetic pathways and is produced from l-aspartate by aspartokinase (Ask) and aspartate-semialdehyde-dehydrogenase (Asd).	Aspartic Acid	112-123	PST_RS09000	Pseudomonas stutzeri A1501	151-187
21746768-3	2011	About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular weight, Ca(2+) requiring, secreted enzymes with a His/Asp catalytic dyad.	Aspartic Acid	165-168	phospholipase A2, group IB, pancreas	Mus musculus	56-62
21746768-3	2011	About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular weight, Ca(2+) requiring, secreted enzymes with a His/Asp catalytic dyad.	Aspartic Acid	165-168	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	64-71
21741339-2	2011	Histatin-5 (Hst-5, DSHAKRHHGYKRKFHEKHHSHRGY), a prominent member of this family contains an albumin-like, N-terminal Asp-Ser-His sequence, known to bind a Ni(II) ion in a square-planar geometry.	Aspartic Acid	117-120	histatin 3	Homo sapiens	0-10
21741339-2	2011	Histatin-5 (Hst-5, DSHAKRHHGYKRKFHEKHHSHRGY), a prominent member of this family contains an albumin-like, N-terminal Asp-Ser-His sequence, known to bind a Ni(II) ion in a square-planar geometry.	Aspartic Acid	117-120	histatin 3	Homo sapiens	12-17
21825134-5	2011	Consistent with this prediction, phosphorylation at these serine residues or mutation to aspartate inhibits binding of p85alpha to tyrosine-phosphorylated peptides.	Aspartic Acid	89-98	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	119-127
21771585-0	2011	Aspartate 458 of human glutathione synthetase is important for cooperativity and active site structure.	Aspartic Acid	0-9	glutathione synthetase	Homo sapiens	23-45
21787747-2	2011	In this study we identified the catalytic triad of diacylglycerol lipase alpha, consisting of serine 472, aspartate 524 and histidine 650.	Aspartic Acid	106-115	diacylglycerol lipase alpha	Homo sapiens	51-78
21807946-6	2011	Furthermore, the phospho-mimetic replacement of all 10 Ser residues in the E(82)SS to SPSP(104) region with Asp resulted in betaTrCP binding.	Aspartic Acid	108-111	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	124-132
21636648-3	2011	The single TM region of PomB or MotB, which forms the ion-conduction pathway together with TM3 and TM4 of PomA or MotA, respectively, has a highly conserved aspartate residue that is the ion binding site and is essential for rotation.	Aspartic Acid	157-166	FRAS1 related extracellular matrix 1	Homo sapiens	114-118
21821879-0	2011	In silico identification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety.	Aspartic Acid	95-108	caspase 3	Homo sapiens	61-70
21287534-4	2011	RESULTS: High expression of the common allele (aspartic acid at codon 1104) of ERCC5, high expression of ERCC1, and BRCA1 haplotype were associated significantly with improved PFR, PFS, and OS.	Aspartic Acid	47-60	ERCC excision repair 5, endonuclease	Homo sapiens	79-84
21529934-1	2011	Platelet adhesion to adsorbed plasma proteins, such as fibrinogen (Fg), has been conventionally thought to be mediated by the GPIIb/IIIa receptor binding to Arg-Gly-Asp (RGD)-like motifs in the adsorbed protein.	Aspartic Acid	165-168	fibrinogen beta chain	Homo sapiens	55-65
21529934-1	2011	Platelet adhesion to adsorbed plasma proteins, such as fibrinogen (Fg), has been conventionally thought to be mediated by the GPIIb/IIIa receptor binding to Arg-Gly-Asp (RGD)-like motifs in the adsorbed protein.	Aspartic Acid	165-168	integrin subunit alpha 2b	Homo sapiens	126-131
21785412-4	2011	Triggering fusion requires the zippering of three crucial aspartate residues in the switch region (residues 64-68) of v-SNARE.	Aspartic Acid	58-67	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	118-125
21691713-5	2011	AGC1 is an important component of the malate/aspartate shuttle, a crucial system supporting oxidative phosphorylation and adenosine triphosphate (ATP) production.	Aspartic Acid	45-54	solute carrier family 25 member 12	Homo sapiens	0-4
21523352-11	2011	In PTs from OCT1/2(-/-) mice ASP uptake was reduced to ~20%.	Aspartic Acid	29-32	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	12-18
21746893-4	2011	To block the synaptic delivery of endogenous AMPARs, we expressed a fragment of the GluR1-cytoplasmic tail (the 14-aa GluR1 membrane-proximal region with two serines mutated to phospho-mimicking aspartates: MPR-DD).	Aspartic Acid	195-205	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-89
21632544-4	2011	Here we report the crystal structures of CCM3 in complex with three different leucine-aspartate repeat (LD) motifs (LD1, LD2, and LD4) from the scaffolding protein paxillin, at 2.8, 2.7, and 2.5 A resolution.	Aspartic Acid	86-95	programmed cell death 10	Homo sapiens	41-45
21681693-4	2011	The aim of this study was to characterise more accurately the contributions of the Asp1 and Asp3 loci in ASP using congenic strains.	Aspartic Acid	105-108	audiogenic seizure prone 1	Mus musculus	83-87
21681693-4	2011	The aim of this study was to characterise more accurately the contributions of the Asp1 and Asp3 loci in ASP using congenic strains.	Aspartic Acid	105-108	audiogenic seizure prone 3	Mus musculus	92-96
21691713-0	2011	The mitochondrial aspartate/glutamate carrier AGC1 and calcium homeostasis: physiological links and abnormalities in autism.	Aspartic Acid	18-27	solute carrier family 25 member 12	Homo sapiens	46-50
21447361-3	2011	The cyclic RGD (Arg-Gly-Asp) peptide, a specific ligand with affinity for Integrin alpha(v)beta(3) was coupled to the distal end of the PEG on the PEG-LP (RGD-PEG-LP).	Aspartic Acid	24-27	integrin subunit alpha V	Homo sapiens	74-98
21762810-4	2011	Mutation to Asp of R252, a crucial determinant of PI(4,5)P(2) binding in the C-terminal domain of Spry2, prevented the interference, indicating that binding to the phospholipid is required.	Aspartic Acid	12-15	sprouty RTK signaling antagonist 2	Homo sapiens	98-103
21670269-5	2011	In addition, it contains two aspartate residues that replace the asparagines encoded in the tyrosinase sequence.	Aspartic Acid	29-38	tyrosinase	Homo sapiens	92-102
21670269-6	2011	We confirmed that this peptide is naturally presented at the surface of melanoma cells, and we showed that its processing sequentially requires translation of tyrosinase into the endoplasmic reticulum and its retrotranslocation into the cytosol, where deglycosylation of the two asparagines by peptide-N-glycanase turns them into aspartates by deamidation.	Aspartic Acid	330-340	tyrosinase	Homo sapiens	159-169
21726810-4	2011	PIDD-induced Caspase-2 directly cleaves the E3 ubiquitin ligase Mdm2 at Asp 367, leading to loss of the C-terminal RING domain responsible for p53 ubiquitination.	Aspartic Acid	72-75	p53-induced death domain protein 1	Homo sapiens	0-4
21683687-0	2011	FcepsilonRI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the FcepsilonRIbeta chain.	Aspartic Acid	73-86	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	0-11
21683687-5	2011	Furthermore, mutagenesis of a single C-terminal aspartic acid (D234) to alanine (beta-D234A) also significantly impaired IL-6 production.	Aspartic Acid	48-61	interleukin 6	Mus musculus	121-125
21586571-9	2011	Intermolecular nuclear Overhauser effect placed aspartate 76 in the vicinity of lysine 381, indicating that the region around residues 73-76 of PC4 is important for p53 recognition.	Aspartic Acid	48-57	SUB1 regulator of transcription	Homo sapiens	144-147
21586571-9	2011	Intermolecular nuclear Overhauser effect placed aspartate 76 in the vicinity of lysine 381, indicating that the region around residues 73-76 of PC4 is important for p53 recognition.	Aspartic Acid	48-57	tumor protein p53	Homo sapiens	165-168
21602277-5	2011	Alanine substitution scanning mutagenesis of 20 Zn(2+)-interacting candidate residues in the outer pore region of the hTRPM2 channel showed that mutation of Lys(952) in the extracellular end of the fifth transmembrane segment and Asp(1002) in the large turret strongly attenuated or abolished Zn(2+) inactivation, and mutation of several other residues dramatically changed the inactivation kinetics.	Aspartic Acid	230-233	transient receptor potential cation channel subfamily M member 2	Homo sapiens	118-124
21611667-8	2011	Mutation of the conserved Asp to Ala in the PAS-GAF-PHY protein had a similar but larger effect.	Aspartic Acid	26-29	fibroblast growth factor 9	Homo sapiens	48-51
21548883-6	2011	We demonstrate that GrB cleaved the intracellular Notch1 domain at least twice at two distinct aspartic acids, Asp1860 and Asp1961.	Aspartic Acid	95-109	granzyme B	Homo sapiens	20-23
21548883-6	2011	We demonstrate that GrB cleaved the intracellular Notch1 domain at least twice at two distinct aspartic acids, Asp1860 and Asp1961.	Aspartic Acid	95-109	notch receptor 1	Homo sapiens	50-56
21610080-3	2011	This interaction requires a second central CaMKII binding site, the densin-IN domain, and an "open" activated CaMKII conformation caused by Ca(2+)/calmodulin binding, autophosphorylation at Thr-286/287, or mutation of Thr-286/287 to Asp.	Aspartic Acid	233-236	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	43-49
21610080-3	2011	This interaction requires a second central CaMKII binding site, the densin-IN domain, and an "open" activated CaMKII conformation caused by Ca(2+)/calmodulin binding, autophosphorylation at Thr-286/287, or mutation of Thr-286/287 to Asp.	Aspartic Acid	233-236	leucine rich repeat containing 7	Homo sapiens	68-74
21610080-3	2011	This interaction requires a second central CaMKII binding site, the densin-IN domain, and an "open" activated CaMKII conformation caused by Ca(2+)/calmodulin binding, autophosphorylation at Thr-286/287, or mutation of Thr-286/287 to Asp.	Aspartic Acid	233-236	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	110-116
21576243-7	2011	The most crucial residue within the beta1-beta2 linker (Asp(110)), when mutated from aspartate to cysteine, can be altered by cysteine-modifying reagents much more readily when channels are closed than when they are desensitized.	Aspartic Acid	56-59	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	36-41
21576243-7	2011	The most crucial residue within the beta1-beta2 linker (Asp(110)), when mutated from aspartate to cysteine, can be altered by cysteine-modifying reagents much more readily when channels are closed than when they are desensitized.	Aspartic Acid	85-94	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	36-41
21604815-2	2011	In the Mtu RecA intein, a conserved block-F aspartate (D422) coordinates different steps in protein splicing, but the precise mechanism is unclear.	Aspartic Acid	44-53	RAD51 recombinase	Homo sapiens	11-15
21726810-4	2011	PIDD-induced Caspase-2 directly cleaves the E3 ubiquitin ligase Mdm2 at Asp 367, leading to loss of the C-terminal RING domain responsible for p53 ubiquitination.	Aspartic Acid	72-75	caspase 2	Homo sapiens	13-22
21726810-4	2011	PIDD-induced Caspase-2 directly cleaves the E3 ubiquitin ligase Mdm2 at Asp 367, leading to loss of the C-terminal RING domain responsible for p53 ubiquitination.	Aspartic Acid	72-75	MDM2 proto-oncogene	Homo sapiens	64-68
21733186-9	2011	CONCLUSIONS: Universal conservation of a set of histidine and aspartate residues across all groups in the CREST superfamily, coupled with independent discoveries of hydrolase activities in alkaline ceramidases and the Per1 family as well as results from previous mutational studies of Per1, suggests that the majority of CREST members are metal-dependent hydrolases.	Aspartic Acid	62-71	SS18L1 subunit of BAF chromatin remodeling complex	Homo sapiens	106-111
21640708-0	2011	Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816.	Aspartic Acid	129-142	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	33-38
21416616-10	2011	The third was biotin-DEVD-AL (DEVD = the amino acid sequence Asp-Glu-Val-Asp), which employed a caspase-3 substrate peptide as a switch to control the accessibility of the substrate to luciferase, and could detect the activity of caspase-3 in a time-dependent manner.	Aspartic Acid	73-76	caspase 3	Homo sapiens	96-105
21714819-5	2011	In GABRA1, two mutations were found, with the first being a 25-bp insertion that was associated with intron retention (i.e. K353delins18X) and the second corresponding to a single point mutation that replaced the aspartate 219 residue with an asparagine (i.e. D219N).	Aspartic Acid	213-222	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	3-9
21424115-1	2011	Citrin is a liver-type aspartate/glutamate carrier (AGC) encoded by the gene SLC25A13.	Aspartic Acid	23-32	solute carrier family 25 member 13	Homo sapiens	0-6
21518786-9	2011	In addition, using mutated Dr fimbriae and a set of mutated hDAFs in which each of the complement control protein (CCP) domains had successively been deleted, we found that the aspartic acids at position 54 in the Dr fimbriae and in CCP domain 4 of hDAF played pivotal roles in the mobilization of the Src kinases and hDAF, respectively.	Aspartic Acid	177-191	CD55 molecule (Cromer blood group)	Homo sapiens	60-64
21518786-9	2011	In addition, using mutated Dr fimbriae and a set of mutated hDAFs in which each of the complement control protein (CCP) domains had successively been deleted, we found that the aspartic acids at position 54 in the Dr fimbriae and in CCP domain 4 of hDAF played pivotal roles in the mobilization of the Src kinases and hDAF, respectively.	Aspartic Acid	177-191	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	302-305
21518786-9	2011	In addition, using mutated Dr fimbriae and a set of mutated hDAFs in which each of the complement control protein (CCP) domains had successively been deleted, we found that the aspartic acids at position 54 in the Dr fimbriae and in CCP domain 4 of hDAF played pivotal roles in the mobilization of the Src kinases and hDAF, respectively.	Aspartic Acid	177-191	CD55 molecule (Cromer blood group)	Homo sapiens	249-253
21424115-1	2011	Citrin is a liver-type aspartate/glutamate carrier (AGC) encoded by the gene SLC25A13.	Aspartic Acid	23-32	solute carrier family 25 member 13	Homo sapiens	77-85
21472811-8	2011	Furthermore, the IkappaBzeta-p50 homodimer complex, which lacks Pro, Glu (and Asp), Ser and Thr (PEST motif), facilitated gene expression.	Aspartic Acid	78-81	NFKB inhibitor zeta	Homo sapiens	17-28
21472811-8	2011	Furthermore, the IkappaBzeta-p50 homodimer complex, which lacks Pro, Glu (and Asp), Ser and Thr (PEST motif), facilitated gene expression.	Aspartic Acid	78-81	nuclear factor kappa B subunit 1	Homo sapiens	29-32
21558810-6	2011	Mutation of this site to the phosphomimetic Asp reduced 14-3-3 binding to the same extent as Ser151Ala mutation, increased substrate access to the catalytic site and Cdc25B activity but had no effect on Ser151 or Ser230 phosphorylation.	Aspartic Acid	44-47	cell division cycle 25B	Homo sapiens	166-172
21453345-3	2011	LHT1 mutants displayed reduced uptake rates of L-Gln, L-Ala, L-Glu and L-Asp but not of L-Arg or L-Lys, while AAP5 mutants were affected in the uptake of L-Arg and L-Lys only.	Aspartic Acid	71-76	lysine histidine transporter 1	Arabidopsis thaliana	0-4
21470975-11	2011	Thus, exchanging the conserved tyrosine (Y(344)) with aspartate in yeast uncouples translational regulation of Cox1 from cytochrome c oxidase assembly and provides evidence for the dual functionality of Shy1.	Aspartic Acid	54-63	Shy1p	Saccharomyces cerevisiae S288C	203-207
21474353-3	2011	CD is caused by mutations in the ASPA gene, which codes for the enzyme aspartoacylase (ASPA), which breaks down N-acetylaspartate (NAA) to acetate and aspartic acid.	Aspartic Acid	151-164	aspartoacylase	Homo sapiens	33-37
21474353-3	2011	CD is caused by mutations in the ASPA gene, which codes for the enzyme aspartoacylase (ASPA), which breaks down N-acetylaspartate (NAA) to acetate and aspartic acid.	Aspartic Acid	151-164	aspartoacylase	Homo sapiens	87-91
21764990-6	2011	In a search for the luminal calcium binding site, structure modeling indicated a possible coordination site formed by residues Glu-450, Asp-454, Glu-456, and Glu-457 on the luminal side of TPC1.	Aspartic Acid	136-139	two-pore channel 1	Arabidopsis thaliana	189-193
21515688-5	2011	Binding experiments with CTRC revealed that (i) inhibitors with Leu at P1 bind 10-fold stronger than those with P1 Met; (ii) Asp at P2" (versus Leu) decreases affinity but increases selectivity, and (iii) Glu or Asp at P4" (versus Ala) increase affinity 10-fold.	Aspartic Acid	125-128	chymotrypsin C	Homo sapiens	25-29
21515688-5	2011	Binding experiments with CTRC revealed that (i) inhibitors with Leu at P1 bind 10-fold stronger than those with P1 Met; (ii) Asp at P2" (versus Leu) decreases affinity but increases selectivity, and (iii) Glu or Asp at P4" (versus Ala) increase affinity 10-fold.	Aspartic Acid	212-215	chymotrypsin C	Homo sapiens	25-29
21467040-7	2011	The conservative exchange of the TM5 glutamate to aspartate (doa10-E633D) results in complete stabilization of Ubc6 but has little if any effect on other substrates.	Aspartic Acid	50-59	E3 ubiquitin-protein ligase SSM4	Saccharomyces cerevisiae S288C	61-66
21467040-7	2011	The conservative exchange of the TM5 glutamate to aspartate (doa10-E633D) results in complete stabilization of Ubc6 but has little if any effect on other substrates.	Aspartic Acid	50-59	E2 ubiquitin-conjugating protein UBC6	Saccharomyces cerevisiae S288C	111-115
21270425-0	2011	Decreased degradation of internalized follicle-stimulating hormone caused by mutation of aspartic acid 6.30(550) in a protein kinase-CK2 consensus sequence in the third intracellular loop of human follicle-stimulating hormone receptor.	Aspartic Acid	89-102	follicle stimulating hormone receptor	Homo sapiens	197-234
22214528-2	2011	The aim of this study was to detect the effect of increased expression of RAGE on the angiogenic response to limb ischemia in diabetes by targeting alphavbeta3 integrin with 99mTc-labeled Arg-Gly-Asp (RGD).	Aspartic Acid	196-199	advanced glycosylation end product-specific receptor	Mus musculus	74-78
21478160-2	2011	GPIHBP1 contains two main structural motifs, an amino-terminal acidic domain enriched in aspartates and glutamates and a lymphocyte antigen 6 (Ly6) motif containing 10 cysteines.	Aspartic Acid	89-99	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1	Cricetulus griseus	0-7
21205219-9	2011	Aspirin administration to CCT diet-fed animals (CCT + Asp) reverted all the studied biochemical and histological changes towards normality.	Aspartic Acid	0-3	FLVCR heme transporter 2	Rattus norvegicus	26-29
21205219-9	2011	Aspirin administration to CCT diet-fed animals (CCT + Asp) reverted all the studied biochemical and histological changes towards normality.	Aspartic Acid	0-3	FLVCR heme transporter 2	Rattus norvegicus	48-51
21365350-1	2011	Citrin is the hepatic mitochondrial aspartate-glutamate carrier that is encoded by the gene SLC25A13.	Aspartic Acid	36-45	solute carrier family 25 member 13	Homo sapiens	0-6
21365350-1	2011	Citrin is the hepatic mitochondrial aspartate-glutamate carrier that is encoded by the gene SLC25A13.	Aspartic Acid	36-45	solute carrier family 25 member 13	Homo sapiens	92-100
21737649-4	2011	In three mutant forms of p53--S15A, S20A and S46A--serine was converted to alanine at these sites to prevent phosphorylation, and in two other mutant forms, S15D and S20D, serine was converted to aspartic acid to mimic phosphorylation.	Aspartic Acid	196-209	tumor protein p53	Homo sapiens	25-28
21270425-1	2011	A naturally occurring mutation in follicle-stimulating hormone receptor (FSHR) gene has been reported: an amino acid change to glycine occurs at a conserved aspartic acid 550 (D550, D567, D6.30(567)).	Aspartic Acid	157-170	follicle stimulating hormone receptor	Homo sapiens	73-77
21270425-1	2011	A naturally occurring mutation in follicle-stimulating hormone receptor (FSHR) gene has been reported: an amino acid change to glycine occurs at a conserved aspartic acid 550 (D550, D567, D6.30(567)).	Aspartic Acid	157-170	follicle stimulating hormone receptor	Homo sapiens	34-71
21491491-0	2011	Structure of an archaeal-type phosphoenolpyruvate carboxylase sensitive to inhibition by aspartate.	Aspartic Acid	89-98	MLO-like protein 4	Zea mays	30-61
21390047-4	2011	Indeed, the univariate hazard ratio (HR) was 2.8 times higher for patients with ERCC5 1104 His/His (P&lt;0.001) compared with ERCC5 1104 Asp/Asp.	Aspartic Acid	137-140	ERCC excision repair 5, endonuclease	Homo sapiens	126-131
21390047-5	2011	Accordingly, the 5-year survival rate was 55% (95% confidence interval 43-71) for patients with ERCC5 1104 His/His, whereas 82% (95% confidence interval 78-86) of patients with ERCC5 1104 Asp/Asp were still alive at this time.	Aspartic Acid	188-191	ERCC excision repair 5, endonuclease	Homo sapiens	177-182
21491491-4	2011	The allosteric binding sites for aspartate (an inhibitor) and glucose-6-phosphate (an activator) observed in the Escherichia coli and Zea mays phosphoenolpyruvate carboxylase structures, respectively, are not conserved in the C. perfringens structure.	Aspartic Acid	33-42	MLO-like protein 4	Zea mays	143-174
21644228-7	2011	Nucleotide sequence alignments with HLA-A allele from the IMGT/HLA Sequence Database showed that the novel A*02 variant allele differed from the closest allele A*02:01:01:01 by nt 383 G to C (codon 128 GAG to GAC) in exon 3, which resulted in one amino acid substitution of Glu to Asp.	Aspartic Acid	281-284	major histocompatibility complex, class I, A	Homo sapiens	36-41
21575572-4	2011	Disruption of the equivalent interaction in Shaker (Trp-434-Asp-447) and Kv1.2 (Trp-366-Asp-379) leads also to modulation of the inactivation process, suggesting that these residues also play an analogous role in the inactivation gating of Kv channels.	Aspartic Acid	60-63	potassium voltage-gated channel subfamily A member 2	Homo sapiens	73-78
21627799-6	2011	Here we demonstrate that delivery of Ub conjugates and docking of Ddi1 (and to a lesser extent Dsk2) to the proteasome are strongly impaired by an aspartic acid to alanine point mutation in the highly-conserved D517 residue of Rpn1.	Aspartic Acid	147-160	Ddi1p	Saccharomyces cerevisiae S288C	66-70
21627799-6	2011	Here we demonstrate that delivery of Ub conjugates and docking of Ddi1 (and to a lesser extent Dsk2) to the proteasome are strongly impaired by an aspartic acid to alanine point mutation in the highly-conserved D517 residue of Rpn1.	Aspartic Acid	147-160	ubiquitin domain-containing protein DSK2	Saccharomyces cerevisiae S288C	95-99
21627799-6	2011	Here we demonstrate that delivery of Ub conjugates and docking of Ddi1 (and to a lesser extent Dsk2) to the proteasome are strongly impaired by an aspartic acid to alanine point mutation in the highly-conserved D517 residue of Rpn1.	Aspartic Acid	147-160	proteasome regulatory particle base subunit RPN1	Saccharomyces cerevisiae S288C	227-231
21454474-6	2011	In the present study, we constructed yeast Rad52 mutants in which the amino acid residues corresponding to the second DNA-binding site of the human Rad52 protein were replaced with either alanine or aspartic acid.	Aspartic Acid	199-212	recombinase RAD52	Saccharomyces cerevisiae S288C	43-48
21575572-4	2011	Disruption of the equivalent interaction in Shaker (Trp-434-Asp-447) and Kv1.2 (Trp-366-Asp-379) leads also to modulation of the inactivation process, suggesting that these residues also play an analogous role in the inactivation gating of Kv channels.	Aspartic Acid	88-91	potassium voltage-gated channel subfamily A member 2	Homo sapiens	73-78
21780371-3	2011	The covalent bond between cyclic RGD (cRGD) containing an Arg-Gly-Asp sequence targeting integrin-alphavbeta3, and USPIO was conducted by chemical crosslinking.	Aspartic Acid	66-69	integrin subunit alpha V	Homo sapiens	89-109
21595127-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	vitronectin	Mus musculus	31-42
21595128-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	vitronectin	Mus musculus	31-42
21490302-8	2011	Resequencing analysis pinpointed the association to a histidine (basic amino acid) for aspartic acid (acidic amino acid) substitution in the encoded protein domain that defines GST substrate specificity and biochemical activity.	Aspartic Acid	87-100	glutathione S-transferase	Zea mays	177-180
21359826-4	2011	In the presence of suitable substrates such as L-aspartate (L-alanine) and alpha-ketoglutarate, AST and ALT generate pyruvate as an enzymatic end product.	Aspartic Acid	47-58	solute carrier family 17 member 5	Homo sapiens	96-99
21540454-1	2011	TRPV6 [transient receptor potential vanilloid 6] is a calcium ion (Ca2+)-selective channel originally identified in the duodenal epithelium and in placenta; replacement of a negatively charged aspartate in the pore-forming region with an uncharged alanine (D541A) renders heterologously expressed TRPV6 channels nonfunctional.	Aspartic Acid	193-202	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	0-5
21540454-1	2011	TRPV6 [transient receptor potential vanilloid 6] is a calcium ion (Ca2+)-selective channel originally identified in the duodenal epithelium and in placenta; replacement of a negatively charged aspartate in the pore-forming region with an uncharged alanine (D541A) renders heterologously expressed TRPV6 channels nonfunctional.	Aspartic Acid	193-202	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	7-47
21540454-1	2011	TRPV6 [transient receptor potential vanilloid 6] is a calcium ion (Ca2+)-selective channel originally identified in the duodenal epithelium and in placenta; replacement of a negatively charged aspartate in the pore-forming region with an uncharged alanine (D541A) renders heterologously expressed TRPV6 channels nonfunctional.	Aspartic Acid	193-202	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	297-302
21623032-2	2011	A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative candidate gene for cardiovascular diseases.	Aspartic Acid	152-165	nitric oxide synthase 3	Homo sapiens	56-89
21623032-2	2011	A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative candidate gene for cardiovascular diseases.	Aspartic Acid	152-165	nitric oxide synthase 3	Homo sapiens	91-95
21297011-2	2011	In this study, we characterized the tooth and jaw phenotypes in transgenic mice containing no wild-type DMP1, but expressing a mutant DMP1 in which Asp(213), a residue at one cleavage site, was replaced by Ala(213) (named "Dmp1-KO/D213A-Tg" mice).	Aspartic Acid	148-151	dentin matrix protein 1	Mus musculus	134-138
21449767-2	2011	It is well established that CITED1 (Cbp/p300 Interacting Transactivators with glutamic acid [E] and aspartic acid [D]-rich C-terminal domain) mRNA is characteristically overexpressed in PTC.	Aspartic Acid	100-113	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1	Homo sapiens	28-34
21279647-6	2011	Concomitantly, it also increases the expression of asparagines synthetase 1 (ASN1) that shifts aspartate utilization towards asparagine formation.	Aspartic Acid	95-104	asparagine synthase (glutamine-hydrolyzing) 1	Saccharomyces cerevisiae S288C	77-81
21500352-1	2011	BACE1 cleaves the amyloid precursor protein (APP) at the beta-cleavage site (Met(671) -Asp(672) ) to initiate the generation of amyloid peptide Abeta.	Aspartic Acid	87-90	beta-secretase 1	Homo sapiens	0-5
21500352-1	2011	BACE1 cleaves the amyloid precursor protein (APP) at the beta-cleavage site (Met(671) -Asp(672) ) to initiate the generation of amyloid peptide Abeta.	Aspartic Acid	87-90	amyloid beta precursor protein	Homo sapiens	18-43
21500352-1	2011	BACE1 cleaves the amyloid precursor protein (APP) at the beta-cleavage site (Met(671) -Asp(672) ) to initiate the generation of amyloid peptide Abeta.	Aspartic Acid	87-90	amyloid beta precursor protein	Homo sapiens	144-149
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Aspartic Acid	17-26	aspartate kinase	Saccharomyces cerevisiae S288C	133-135
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Aspartic Acid	17-26	aspartate kinase	Saccharomyces cerevisiae S288C	161-163
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Aspartic Acid	17-26	aspartate kinase	Saccharomyces cerevisiae S288C	169-185
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Aspartic Acid	17-26	aspartate kinase	Saccharomyces cerevisiae S288C	161-163
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Aspartic Acid	57-60	aspartate kinase	Saccharomyces cerevisiae S288C	133-135
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Aspartic Acid	57-60	aspartate kinase	Saccharomyces cerevisiae S288C	161-163
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Aspartic Acid	57-60	aspartate kinase	Saccharomyces cerevisiae S288C	169-185
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Aspartic Acid	57-60	aspartate kinase	Saccharomyces cerevisiae S288C	161-163
21297160-9	2011	Comparison of the secondary structure with those of known enzymes exhibiting substrate-assisted catalysis and point mutation analysis indicated that NgaP adopts substrate-assisted catalysis in which Glu-608 and Asp-607 could function as a proton donor and a stabilizer of the 2-acetamide group of the beta-GalNAc at the active site, respectively.	Aspartic Acid	211-214	RAS protein activator like 2	Homo sapiens	149-153
21552498-7	2011	Sequencing of GJA3 revealed a G&gt;A transition at nucleotide position c.139, which causes an Asn substitution for the conservative Asp at codon 47 (P.D47N).This mutation is identified in all affected individuals but is not found in 100 control chromosomes.	Aspartic Acid	132-135	gap junction protein alpha 3	Homo sapiens	14-18
21333652-6	2011	The models, based on a combination of Brownian and molecular dynamics simulations, predict that the binding site on sAnk1 for obscurin is organized as two ankyrin-like repeats, with the last alpha-helical segment oriented at an angle to nearby helices, allowing lysine 6338 of obscurin to form an ionic interaction with aspartate 111 of sAnk1.	Aspartic Acid	320-329	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	Homo sapiens	126-134
21333724-3	2011	AIM OF THE STUDY: Previous study indicated that Angelica sinensis polysaccharide (ASP) may promote plasma iron levels by suppressing the expression of hepcidin, a negative regulator of body iron metabolism, in the liver.	Aspartic Acid	82-85	hepcidin antimicrobial peptide	Rattus norvegicus	151-159
21339291-7	2011	Here, we further found that the ER (endoplasmic reticulum) stress- or staurosporine-mediated activation of caspases leads to cleavage of TDP-43 at Asp(89) and Asp(169), generating CTF35 (TDP-43-(90-414)) and CTF27 (TDP-43-(170-414)) in cultured neuronal cells.	Aspartic Acid	147-150	TAR DNA binding protein	Homo sapiens	137-143
21339291-7	2011	Here, we further found that the ER (endoplasmic reticulum) stress- or staurosporine-mediated activation of caspases leads to cleavage of TDP-43 at Asp(89) and Asp(169), generating CTF35 (TDP-43-(90-414)) and CTF27 (TDP-43-(170-414)) in cultured neuronal cells.	Aspartic Acid	147-150	TAR DNA binding protein	Homo sapiens	187-193
21339291-7	2011	Here, we further found that the ER (endoplasmic reticulum) stress- or staurosporine-mediated activation of caspases leads to cleavage of TDP-43 at Asp(89) and Asp(169), generating CTF35 (TDP-43-(90-414)) and CTF27 (TDP-43-(170-414)) in cultured neuronal cells.	Aspartic Acid	147-150	TAR DNA binding protein	Homo sapiens	187-193
21339291-7	2011	Here, we further found that the ER (endoplasmic reticulum) stress- or staurosporine-mediated activation of caspases leads to cleavage of TDP-43 at Asp(89) and Asp(169), generating CTF35 (TDP-43-(90-414)) and CTF27 (TDP-43-(170-414)) in cultured neuronal cells.	Aspartic Acid	159-162	TAR DNA binding protein	Homo sapiens	187-193
21339291-7	2011	Here, we further found that the ER (endoplasmic reticulum) stress- or staurosporine-mediated activation of caspases leads to cleavage of TDP-43 at Asp(89) and Asp(169), generating CTF35 (TDP-43-(90-414)) and CTF27 (TDP-43-(170-414)) in cultured neuronal cells.	Aspartic Acid	159-162	TAR DNA binding protein	Homo sapiens	187-193
21343289-4	2011	Here, we describe a novel protein, DAR1, from A. californica that can convert aspartate and serine to their other chiral form in a pyridoxal 5"-phosphate (PLP)-dependent manner.	Aspartic Acid	78-87	amino acid racemase	Aplysia californica	35-39
21343289-5	2011	DAR1 has a predicted length of 325 amino acids and is 55% identical to the bivalve aspartate racemase, EC 5.1.1.13, and 41% identical to the mammalian serine racemase, EC 5.1.1.18.	Aspartic Acid	83-92	amino acid racemase	Aplysia californica	0-4
21343289-8	2011	The biochemical and functional similarities between DAR1 and other animal serine and aspartate racemases make it valuable for examining PLP-dependent racemases, promising to increase our knowledge of enzyme regulation and ultimately, D-serine and D-Asp signaling pathways.	Aspartic Acid	85-94	amino acid racemase	Aplysia californica	52-56
21310952-8	2011	Mutation of the homologue Asp residue in human PP2Calpha also caused loss of function, suggesting a general requirement of M3 in PPM-catalyzed reactions.	Aspartic Acid	26-29	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	47-56
21333724-4	2011	The present study aims to clarify the inhibitory effect of ASP on hepcidin expression as well as the involved mechanisms.	Aspartic Acid	59-62	hepcidin antimicrobial peptide	Rattus norvegicus	66-74
21333724-5	2011	MATERIALS AND METHODS: ASP (1g/kg) or vehicle (normal saline) was intragastrically administrated to rats everyday for 14 d. Intraperitoneal injections of recombinant human erythropoietin (rhEPO, 2000 U/kg) were given to positive control group.	Aspartic Acid	23-26	erythropoietin	Homo sapiens	172-186
21333724-9	2011	CONCLUSIONS: ASP can suppress the expression of hepcidin in normal rats, and may be used in the treatments of hepcidin-induced diseases.	Aspartic Acid	13-16	hepcidin antimicrobial peptide	Rattus norvegicus	48-56
21333724-9	2011	CONCLUSIONS: ASP can suppress the expression of hepcidin in normal rats, and may be used in the treatments of hepcidin-induced diseases.	Aspartic Acid	13-16	hepcidin antimicrobial peptide	Rattus norvegicus	110-118
21364531-7	2011	Choline binding to a location close to the second, low-affinity sodium-binding site (Na2) of LeuT-fold transporters is facilitated by the introduced aspartate.	Aspartic Acid	149-158	Leucine transport, high	Homo sapiens	93-97
21491703-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Mus musculus	121-132
21296888-5	2011	The Asp-42 in the CC" loop of D1 was indispensable for MAdCAM-1 binding to both low-affinity and high-affinity alpha4beta7.	Aspartic Acid	4-7	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	55-63
21306562-5	2011	Site-directed mutagenesis of the catalytic tetrad of AKR1B1, composed of Tyr, Lys, His and Asp, revealed that the triad of Asp43, Lys77 and His110, but not Tyr48, acts as a proton donor in most AKR activities, and is crucial for PGD(2) and PGF(2alpha) synthase activities.	Aspartic Acid	91-94	aldo-keto reductase family 1 member B	Homo sapiens	53-59
21332708-6	2011	The levels of FLT3 expression, as assessed by flow cytometry and FLT3 mutational status, was used to identify four AML subgroups: FLT3WTH (14/94); FLT3 Wild-type low (FLT3WTL, 48/94); FLT3 internal tandem duplication (FLT3ITD 26/94); FLT3 aspartic acid 835 (FLT3D835, 6/94).	Aspartic Acid	239-252	fms related receptor tyrosine kinase 3	Homo sapiens	14-18
21276770-0	2011	Induction of integrin beta3 in PGE2-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.	Aspartic Acid	98-101	integrin beta 3	Mus musculus	13-27
21276770-0	2011	Induction of integrin beta3 in PGE2-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.	Aspartic Acid	98-101	fibronectin 1	Mus musculus	123-134
21422763-3	2011	To address this issue, the presumed phosphorylation site of CiaR, aspartic acid at position 51, was replaced by alanine.	Aspartic Acid	66-79	ciaR	Streptococcus pneumoniae R6	60-64
21330192-1	2011	BACKGROUND: Aspartic acid to glycine substitution (D222G) of haemagglutinin subunit (HA1) was associated with adverse outcomes in 2009 pandemic influenza A (H1N1) infections.	Aspartic Acid	12-25	Rho GTPase activating protein 45	Homo sapiens	85-88
21117863-6	2011	OR for PIH and mild preeclampsia was 1.08 (p = 1) and 9.45 (p = 0.06), respectively, in association with the Asp/Asp genotype.	Aspartic Acid	109-112	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	7-10
21117863-6	2011	OR for PIH and mild preeclampsia was 1.08 (p = 1) and 9.45 (p = 0.06), respectively, in association with the Asp/Asp genotype.	Aspartic Acid	113-116	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	7-10
21077118-1	2011	A monofunctional catalase from Serratia marcescens SYBC08 produced by liquid state fermentation in 7 liter fermenter was isolated and purified by ammonium sulfate precipitation (ASP), ion exchange chromatography (IEC), and gel filtration (GF) and characterized.	Aspartic Acid	178-181	catalase	Bos taurus	17-25
21316765-6	2011	The other patient carried an A&gt;T substitution in exon 6 (c.866A&gt;T) encoding the LDLr2 (low density lipoprotein receptor) domain (p.D289V), resulting in an aspartic acid to valine change.	Aspartic Acid	161-174	low density lipoprotein receptor	Homo sapiens	93-125
21257813-8	2011	The positive charge in K20 and the polar amide group in N27 appeared to interact with electronegative groups, since the replacement of these two residues with a positive (Arg) residue was well tolerated, while replacement with a negative (Asp) residue was detrimental to the bacteriocin activity.	Aspartic Acid	239-242	keratin 20	Homo sapiens	23-26
21228277-3	2011	The C-terminal catalytic domain is similar to UfSP1 with Cys(294), Asp(418), His(420), Tyr(282), and a regulatory loop participating in catalysis.	Aspartic Acid	67-70	UFM1-specific peptidase 1	Mus musculus	46-51
20641300-6	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) was identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Aspartic Acid	44-47	vitronectin	Homo sapiens	131-142
20641300-6	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) was identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Aspartic Acid	44-47	fibrinogen beta chain	Homo sapiens	144-154
21163943-2	2011	During its catalytic cycle, Ccc2 undergoes auto-phosphorylation on Asp(627) and uses the energy gained to transport copper across the cell membrane.	Aspartic Acid	67-70	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	28-32
20953700-5	2011	Aspartate mechanisms include vesicular transport by sialin, vesicular content sensitive to glucose concentration, release mainly outside the presynaptic active zones, and selective activation of extrasynaptic NR1-NR2B NMDA receptors.	Aspartic Acid	0-9	solute carrier family 17 member 5	Homo sapiens	52-58
20953700-6	2011	Possible neurobiological functions of aspartate in immature neurons include activation of cAMP-dependent gene transcription and in mature neurons inhibition of CREB function, reduced BDNF expression, and induction of excitotoxic neuronal death.	Aspartic Acid	38-47	cAMP responsive element binding protein 1	Homo sapiens	160-164
20953700-6	2011	Possible neurobiological functions of aspartate in immature neurons include activation of cAMP-dependent gene transcription and in mature neurons inhibition of CREB function, reduced BDNF expression, and induction of excitotoxic neuronal death.	Aspartic Acid	38-47	brain derived neurotrophic factor	Homo sapiens	183-187
21239490-7	2011	Actin binding required Yih1 residues 68-258, encompassing part of the RWD and the C-terminal "ancient domain"; however, residues Asp-102 and Glu-106 in helix3 of the RWD were essential for Gcn1 binding and Gcn2 inhibition but dispensable for actin binding.	Aspartic Acid	129-132	GCN1 activator of EIF2AK4	Homo sapiens	189-193
21148411-8	2011	AII-induced ERK activation was reduced by &gt;65% by synthetic peptides containing an RGD (arginine-glycine-aspartic acid) sequence that inhibit alpha(5)beta(1)-integrin, and by ~60% by the KTS (lysine-threonine-serine)-containing peptides specific for integrin-alpha(1)beta(1).	Aspartic Acid	108-121	angiotensinogen	Homo sapiens	0-3
21148411-8	2011	AII-induced ERK activation was reduced by &gt;65% by synthetic peptides containing an RGD (arginine-glycine-aspartic acid) sequence that inhibit alpha(5)beta(1)-integrin, and by ~60% by the KTS (lysine-threonine-serine)-containing peptides specific for integrin-alpha(1)beta(1).	Aspartic Acid	108-121	mitogen-activated protein kinase 1	Homo sapiens	12-15
21357733-3	2011	Here, we examined the role of Asp-433 and Gly-432 in channel kinetics, ion selectivity, conductance, and Ca(2+) block in lamprey ASIC1 that is a channel with little intrinsic desensitization in the pH range of maximal activity, pH 7.0.	Aspartic Acid	30-33	acid sensing ion channel subunit 1	Gallus gallus	129-134
21357733-10	2011	The constriction made by Asp-433 and Gly-432 does not select for ions in the open conformation, implying that the closing gate and selectivity filter are separate structural elements in the ion pathway of ASIC1.	Aspartic Acid	25-28	acid sensing ion channel subunit 1	Gallus gallus	205-210
21329514-4	2011	A functional aspartic acid (D) repeat polymorphism of ASPN was first described as an osteoarthritis-associated polymorphism.	Aspartic Acid	13-26	asporin	Homo sapiens	54-58
21135090-6	2011	We show that STAT1, -3, and -5 proteins are activated downstream of the KIT-Asp(816) mutant.	Aspartic Acid	76-79	signal transducer and activator of transcription 1	Homo sapiens	13-30
21135090-6	2011	We show that STAT1, -3, and -5 proteins are activated downstream of the KIT-Asp(816) mutant.	Aspartic Acid	76-79	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	72-75
21338883-5	2011	Using an aspartate mutation in the C2B domain (D364N) in which Ca2+ triggering was abolished but release clamping remained intact, we show that Syt2 strongly suppresses the action of another, near-linear Ca2+ sensor that mediates release over a wide range of [Ca2+](i).	Aspartic Acid	9-18	synaptotagmin 2	Homo sapiens	144-148
21119198-4	2011	We employed random mutagenesis of leptin, followed by selection of high affinity mutants by yeast surface display and discovered that replacing residue Asp-23 with a non-negatively charged amino acid leads to dramatically enhanced affinity of leptin for its soluble receptor.	Aspartic Acid	152-155	leptin	Mus musculus	34-40
21172315-3	2011	Transgenic mice have been generated with the Plp promoter driving expression of a modified form of Akt, in which aspartic acids are substituted for Thr308 and Ser473.	Aspartic Acid	113-127	proteolipid protein (myelin) 1	Mus musculus	45-48
21172315-3	2011	Transgenic mice have been generated with the Plp promoter driving expression of a modified form of Akt, in which aspartic acids are substituted for Thr308 and Ser473.	Aspartic Acid	113-127	thymoma viral proto-oncogene 1	Mus musculus	99-102
21119198-4	2011	We employed random mutagenesis of leptin, followed by selection of high affinity mutants by yeast surface display and discovered that replacing residue Asp-23 with a non-negatively charged amino acid leads to dramatically enhanced affinity of leptin for its soluble receptor.	Aspartic Acid	152-155	leptin	Mus musculus	243-249
21097875-0	2011	The catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease action.	Aspartic Acid	14-23	coagulation factor II, thrombin	Homo sapiens	159-174
21175197-8	2011	A highly conserved aspartic acid within the MetRS SCF is proposed to make an electrostatic interaction with an active site lysine; these residues were replaced with alanines or conservative substitutions.	Aspartic Acid	19-32	KIT ligand	Homo sapiens	50-53
21347309-4	2011	This domain comprises a pentapeptide sequence motif GxSxG/S at the N-terminus and conserved amino acid residues Ser, Asp and His that constitute a catalytic triad characteristic of lipase, esterase and cutinase activity.	Aspartic Acid	117-120	lipase	Mycobacterium tuberculosis H37Rv	181-187
21347309-4	2011	This domain comprises a pentapeptide sequence motif GxSxG/S at the N-terminus and conserved amino acid residues Ser, Asp and His that constitute a catalytic triad characteristic of lipase, esterase and cutinase activity.	Aspartic Acid	117-120	esterase	Mycobacterium tuberculosis H37Rv	189-197
20661636-5	2011	We had reported recently that the expression of CTP:phosphocholine cytidylyltransferase alpha (CCT-alpha) was inhibited during N-methyl-D: -aspartic acid (NMDA)-induced lung injury.	Aspartic Acid	140-153	phosphate cytidylyltransferase 1A, choline	Homo sapiens	48-93
20661636-5	2011	We had reported recently that the expression of CTP:phosphocholine cytidylyltransferase alpha (CCT-alpha) was inhibited during N-methyl-D: -aspartic acid (NMDA)-induced lung injury.	Aspartic Acid	140-153	phosphate cytidylyltransferase 1A, choline	Homo sapiens	95-104
21185261-5	2011	These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel.	Aspartic Acid	31-34	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	43-49
21270901-8	2011	The interaction of PSD95 with nNOS controls synapse formation and is implicated in N-methyl-D-aspartic acid-induced neuronal death.	Aspartic Acid	94-107	discs large MAGUK scaffold protein 4	Homo sapiens	19-24
21270901-8	2011	The interaction of PSD95 with nNOS controls synapse formation and is implicated in N-methyl-D-aspartic acid-induced neuronal death.	Aspartic Acid	94-107	nitric oxide synthase 1	Homo sapiens	30-34
21185261-5	2011	These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel.	Aspartic Acid	31-34	polycystin 1 like 3, transient receptor potential channel interacting	Homo sapiens	101-107
21185261-5	2011	These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel.	Aspartic Acid	31-34	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	108-114
21185261-5	2011	These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel.	Aspartic Acid	31-34	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	108-114
21185261-5	2011	These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel.	Aspartic Acid	31-34	polycystin 1 like 3, transient receptor potential channel interacting	Homo sapiens	178-184
21185261-5	2011	These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel.	Aspartic Acid	31-34	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	108-114
21123452-4	2011	To explore the role of the mutated aspartic acid residue in SMO function, we substituted D473 with every amino acid and found that all functional mutants were resistant to GDC-0449, with positively charged residues conferring potential oncogenic properties.	Aspartic Acid	35-48	smoothened, frizzled class receptor	Homo sapiens	60-63
21078669-7	2011	Guided by structural bioinformatics including protein-protein docking, we revealed that the amino acids Arg(63), Lys(70), Lys(101), Glu(138), Asp(139), and Asn(160) engage in intermolecular salt bridges within the anxA5 trimer, which is the basic building block of the two-dimensional network.	Aspartic Acid	142-145	annexin A5	Homo sapiens	214-219
21157428-5	2011	While caspase-8 and caspase-3 are unable to induce activation of purified pro-A-SMase, we found that caspase-7 mediates A-SMase activation by direct interaction resulting in proteolytic cleavage of the 72-kDa pro-A-SMase zymogen at the non-canonical cleavage site after aspartate 253, generating an active 57 kDa A-SMase molecule.	Aspartic Acid	270-279	caspase 7	Homo sapiens	101-110
21036942-2	2011	During the systematic screening of mutations of the different genes of the renin-angiotensin system associated with RTD, two missense mutations in the renin gene were previously identified, the first affects one of the two catalytic aspartates (D38N) of renin, and the second, S69Y, is located upstream of the "flap", a mobile beta-hairpin structure which covers the substrate-binding site of renin.	Aspartic Acid	233-243	renin	Cricetulus griseus	75-80
21036942-2	2011	During the systematic screening of mutations of the different genes of the renin-angiotensin system associated with RTD, two missense mutations in the renin gene were previously identified, the first affects one of the two catalytic aspartates (D38N) of renin, and the second, S69Y, is located upstream of the "flap", a mobile beta-hairpin structure which covers the substrate-binding site of renin.	Aspartic Acid	233-243	renin	Cricetulus griseus	151-156
21036942-2	2011	During the systematic screening of mutations of the different genes of the renin-angiotensin system associated with RTD, two missense mutations in the renin gene were previously identified, the first affects one of the two catalytic aspartates (D38N) of renin, and the second, S69Y, is located upstream of the "flap", a mobile beta-hairpin structure which covers the substrate-binding site of renin.	Aspartic Acid	233-243	renin	Cricetulus griseus	151-156
21036942-2	2011	During the systematic screening of mutations of the different genes of the renin-angiotensin system associated with RTD, two missense mutations in the renin gene were previously identified, the first affects one of the two catalytic aspartates (D38N) of renin, and the second, S69Y, is located upstream of the "flap", a mobile beta-hairpin structure which covers the substrate-binding site of renin.	Aspartic Acid	233-243	renin	Cricetulus griseus	151-156
21059642-4	2011	Mutation of the three RUNX1 serines to aspartic acid reduces co-immunoprecipitation with HDAC1 or HDAC3 when expressed in 293T cells; mutation of these three serines to alanine increases HDAC interaction, and mutation of each serine individually to aspartic acid also reduces these interactions.	Aspartic Acid	39-52	histone deacetylase 1	Homo sapiens	89-94
21056976-4	2011	Here, we show that SRPK2 is cleaved by caspases at Asp-139 and -403 residues.	Aspartic Acid	51-54	SRSF protein kinase 2	Homo sapiens	19-24
21059642-4	2011	Mutation of the three RUNX1 serines to aspartic acid reduces co-immunoprecipitation with HDAC1 or HDAC3 when expressed in 293T cells; mutation of these three serines to alanine increases HDAC interaction, and mutation of each serine individually to aspartic acid also reduces these interactions.	Aspartic Acid	39-52	histone deacetylase 3	Homo sapiens	98-103
21059642-4	2011	Mutation of the three RUNX1 serines to aspartic acid reduces co-immunoprecipitation with HDAC1 or HDAC3 when expressed in 293T cells; mutation of these three serines to alanine increases HDAC interaction, and mutation of each serine individually to aspartic acid also reduces these interactions.	Aspartic Acid	249-262	RUNX family transcription factor 1	Homo sapiens	22-27
21059642-4	2011	Mutation of the three RUNX1 serines to aspartic acid reduces co-immunoprecipitation with HDAC1 or HDAC3 when expressed in 293T cells; mutation of these three serines to alanine increases HDAC interaction, and mutation of each serine individually to aspartic acid also reduces these interactions.	Aspartic Acid	39-52	RUNX family transcription factor 1	Homo sapiens	22-27
21059642-6	2011	The ability of RUNX1 phosphorylation and not only serine to aspartic acid conversion to reduce HDAC1 binding was demonstrated using wild-type GST-RUNX1 phosphorylated in vitro using cdk1/cyclinB and by exposure of 293T cells transduced with RUNX1 and HDAC1 to roscovitine, a cdk inhibitor.	Aspartic Acid	60-73	histone deacetylase 1	Homo sapiens	95-100
20939034-4	2011	Here, we designed a novel scaffold where fibronectin-derived Gly Arg-Gly-Asp-Ser (GRGDS) and Pro-His-Ser-Arg-Asn (PHSRN) peptides were simultaneously conjugated with poly(Pro-Hyp-Gly).	Aspartic Acid	73-76	fibronectin 1	Bos taurus	41-52
21249762-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
21249762-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
21183353-4	2011	The most potent inhibitor, tert-alcohol containing (R)-12 (IC(50)=0.19muM) was co-crystallized in the active site of the BACE-1 protease, furnishing a novel binding mode in which the N-terminal amine makes a hydrogen bond to one of the catalytic aspartic acids.	Aspartic Acid	246-260	latexin	Homo sapiens	70-73
21214909-6	2011	The final SNP (rs41694656) was located in the first exon of transcripts encoding the putative bovine neuroendocrine-specific protein NESP55, resulting in an aspartic acid-to-asparagine amino acid substitution at amino acid position 192.	Aspartic Acid	157-170	GNAS complex locus	Bos taurus	133-139
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Aspartic Acid	114-127	prion like protein doppel	Homo sapiens	25-28
21183353-4	2011	The most potent inhibitor, tert-alcohol containing (R)-12 (IC(50)=0.19muM) was co-crystallized in the active site of the BACE-1 protease, furnishing a novel binding mode in which the N-terminal amine makes a hydrogen bond to one of the catalytic aspartic acids.	Aspartic Acid	246-260	beta-secretase 1	Homo sapiens	121-127
22252749-5	2011	The catalytic site of cathepsin E is two residues of aspartic acid - Asp96 and Asn281, occurring in amino acid triads with sequences DTG96-98 and DTG281-283.	Aspartic Acid	53-66	cathepsin E	Homo sapiens	22-33
21069403-4	2011	The amino acid sequence comparison and phylogenetic analysis indicated that it could be classified as a subtilisin-like serine protease, though the highly conserved residue Asp was replaced by Ala.	Aspartic Acid	173-176	coagulation factor II, thrombin	Homo sapiens	120-135
21691091-0	2011	Integrin signaling modulates AQP2 trafficking via Arg-Gly-Asp (RGD) motif.	Aspartic Acid	58-61	aquaporin 2	Homo sapiens	29-33
21591931-2	2011	The secreted proLOX is enzymatically quiescent and is activated through proteolytic cleavage between residues Gly(162) and Asp(163) (residue numbers according to the mouse LOX) by bone morphogenetic protein (BMP)-1 gene products.	Aspartic Acid	123-126	lysyl oxidase	Mus musculus	16-19
21591931-2	2011	The secreted proLOX is enzymatically quiescent and is activated through proteolytic cleavage between residues Gly(162) and Asp(163) (residue numbers according to the mouse LOX) by bone morphogenetic protein (BMP)-1 gene products.	Aspartic Acid	123-126	bone morphogenetic protein 1	Mus musculus	180-214
22191059-2	2011	The results indicate that the N-terminal Asp binds to Cu(II) together with His6 and either His13 or His14 to form the lower pH Component I of Abeta.	Aspartic Acid	41-44	amyloid beta precursor protein	Homo sapiens	142-147
21304263-2	2011	This biological activity of OPN may be attributed to its characteristic structure, which includes 2 calcium binding sites, Arg-Gly-Asp (RGD) sequences.	Aspartic Acid	131-134	secreted phosphoprotein 1	Mus musculus	28-31
21123949-1	2011	Solute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major epithelial transporter of glutamate and aspartate in the kidneys and intestines of rodents.	Aspartic Acid	127-136	solute carrier family 1 member 1	Homo sapiens	0-33
21098975-7	2011	As expected, induction of caspase-3 activation and cleavage of tau protein at its specific site (aspartic acid 421) was observed by Western blot and immunofluorescence analyses in mice neuronal primary cultures infected with HSV-1.	Aspartic Acid	97-110	caspase 3	Mus musculus	26-35
20736955-3	2011	The deficiency in Aralar/AGC1, the main mitochondrial carrier for aspartate-glutamate expressed in brain, results in a drastic fall in brain glutamine production but a modest decrease in brain glutamate levels, which is not due to decreases in neuronal or synaptosomal glutamate content.	Aspartic Acid	66-75	solute carrier family 25 member 12	Homo sapiens	25-29
20736955-5	2011	Aralar deficiency induces a decrease in aspartate content, an increase in lactate production, and lactate-to-pyruvate ratio in cultured neurons but not in cultured astrocytes, indicating that Aralar is only functional in neurons.	Aspartic Acid	40-49	solute carrier family 25 member 12	Homo sapiens	0-6
21673902-2	2011	More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad.	Aspartic Acid	181-184	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	27-32
21673902-2	2011	More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad.	Aspartic Acid	181-184	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	27-33
21673902-2	2011	More than one third of the PLA(2) enzymes belong to the secreted PLA(2) (sPLA(2)) family, which consists of low-molecular-weight, Ca(2+)-requiring extracellular enzymes, with a His-Asp catalytic dyad.	Aspartic Acid	181-184	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	73-80
21123949-1	2011	Solute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major epithelial transporter of glutamate and aspartate in the kidneys and intestines of rodents.	Aspartic Acid	127-136	solute carrier family 1 member 1	Homo sapiens	35-41
21123949-1	2011	Solute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major epithelial transporter of glutamate and aspartate in the kidneys and intestines of rodents.	Aspartic Acid	127-136	solute carrier family 1 member 1	Homo sapiens	57-62
21123949-1	2011	Solute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major epithelial transporter of glutamate and aspartate in the kidneys and intestines of rodents.	Aspartic Acid	127-136	solute carrier family 1 member 1	Homo sapiens	67-72
21123949-4	2011	Here we report that SLC1A1 mutations leading to substitution of arginine to tryptophan at position 445 (R445W) and deletion of isoleucine at position 395 (I395del) cause human dicarboxylic aminoaciduria, an autosomal recessive disorder of urinary glutamate and aspartate transport that can be associated with mental retardation.	Aspartic Acid	261-270	solute carrier family 1 member 1	Homo sapiens	20-26
21123949-6	2011	These findings provide evidence that SLC1A1 is the major renal transporter of glutamate and aspartate in humans and implicate SLC1A1 in the pathogenesis of some neurological disorders.	Aspartic Acid	92-101	solute carrier family 1 member 1	Homo sapiens	37-43
20140889-8	2011	Elimination of the Ca(2+)-binding capacity by substitution of the respective aspartate residues in a D92N/D94N double-substituted variant reduces the Bcl-2 affinity of the FKBP38(35-153)/CaM complex to the same degree as the presence of Ca(2+) in the wild-type protein.	Aspartic Acid	77-86	BCL2 apoptosis regulator	Homo sapiens	150-155
21134608-5	2011	At this pH, H2B(32-62) presented the formation of coordination isomers, differentiated by the presence in one of them, of an axial coordination of the carboxylate group of Asp(50).	Aspartic Acid	172-175	H2B clustered histone 21	Homo sapiens	12-15
20811396-1	2011	Fibronectin (FN) is required for embryogenesis, morphogenesis, and wound repair, and its Arg-Gly-Asp-containing central cell-binding domain (CCBD) is essential for mesenchymal cell survival and growth.	Aspartic Acid	97-100	fibronectin 1	Homo sapiens	0-11
20811396-1	2011	Fibronectin (FN) is required for embryogenesis, morphogenesis, and wound repair, and its Arg-Gly-Asp-containing central cell-binding domain (CCBD) is essential for mesenchymal cell survival and growth.	Aspartic Acid	97-100	fibronectin 1	Homo sapiens	13-15
21081141-4	2011	The VvRtxA C-terminal Gly-Asp (GD) repeat-containing region, which has been implicated for calcium binding and target cell recognition, was chosen as an antigen to screen a scFv phage display library.	Aspartic Acid	26-29	RTX toxin RtxA	Vibrio vulnificus	4-10
20140889-8	2011	Elimination of the Ca(2+)-binding capacity by substitution of the respective aspartate residues in a D92N/D94N double-substituted variant reduces the Bcl-2 affinity of the FKBP38(35-153)/CaM complex to the same degree as the presence of Ca(2+) in the wild-type protein.	Aspartic Acid	77-86	FKBP prolyl isomerase 8	Homo sapiens	172-178
20974254-8	2011	SHBG levels tended to be higher among the subjects with the Asn/Asn (25.84+-3.6nmol/l) and S/S (24.50+-5.4nmol/l) genotypes compared to subjects with the Asp/Asn (24.38+-3.2nmol/l) and L/L (18.44+-4.2nmol/l) genotypes of the SHBG gene.	Aspartic Acid	154-157	sex hormone binding globulin	Homo sapiens	0-4
21282934-5	2011	These results suggest that caspase-4 directly activates caspase-9 by the processing of procaspase-9 at Asp-315 in ER stress-induced neuronal apoptosis.	Aspartic Acid	103-106	caspase 4	Homo sapiens	27-36
21282934-5	2011	These results suggest that caspase-4 directly activates caspase-9 by the processing of procaspase-9 at Asp-315 in ER stress-induced neuronal apoptosis.	Aspartic Acid	103-106	caspase 9	Homo sapiens	56-65
32272543-5	2011	These results suggest that caspase-4 directly activates caspase-9 by the processing of procaspase-9 at Asp-315 in ER stress-induced neuronal apoptosis.	Aspartic Acid	103-106	caspase 4	Homo sapiens	27-36
32272543-5	2011	These results suggest that caspase-4 directly activates caspase-9 by the processing of procaspase-9 at Asp-315 in ER stress-induced neuronal apoptosis.	Aspartic Acid	103-106	caspase 9	Homo sapiens	56-65
22132110-4	2011	Neutralizing antibody to integrin alphavbeta3 and an integrin-binding Arg-Gly-Asp (RGD) peptide blocked thyroid hormone-induced PCNA expression.	Aspartic Acid	78-81	proliferating cell nuclear antigen	Homo sapiens	128-132
21072045-6	2011	The aspartate metabolism pathway was the most overrepresented among 199 pathways evaluated (P=8.1 x 10(-3)), with primary involvement of adenylosuccinate lyase and aspartyl-tRNA synthetase genes.	Aspartic Acid	4-13	adenylosuccinate lyase	Homo sapiens	137-159
21837563-8	2011	CDKA;1 versions were generated either by mimicking a phosphorylated amino acid by replacing the respective residue with a negatively charged amino acid, e.g., aspartate or glutamate, or by mutating it to a non-phoshorylatable amino acid, such as alanine, valine, or phenylalanine.	Aspartic Acid	159-168	cell division control 2	Arabidopsis thaliana	0-6
21114375-1	2011	TRH-like peptides are characterized by substitution of basic amino acid histidine (related to authentic TRH) with neutral or acidic amino acid, like glutamic acid, phenylalanine, glutamine, tyrosine, leucin, valin, aspartic acid and asparagine.	Aspartic Acid	215-228	thyrotropin releasing hormone	Homo sapiens	0-3
21980421-3	2011	Currently, Glu314, Ser346, Lys347 and Lys362 in human c-NADP-ME were changed to the corresponding residues of human m-NAD(P)-ME (Glu, Lys, Tyr and Gln, respectively) or Ascaris suum m-NAD-ME (Ala, Ile, Asp and His, respectively).	Aspartic Acid	202-205	malic enzyme 1	Homo sapiens	56-63
21625469-1	2011	Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate.	Aspartic Acid	191-200	aspartoacylase	Mus musculus	125-129
21858081-11	2011	A disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8, mediating the formation of TRAPPII and/or TRAPPIII.	Aspartic Acid	112-121	trafficking protein particle complex subunit 2	Homo sapiens	30-37
21858081-11	2011	A disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8, mediating the formation of TRAPPII and/or TRAPPIII.	Aspartic Acid	112-121	trafficking protein particle complex subunit 2	Homo sapiens	128-135
20937827-4	2010	However, we identified a site phosphorylated by Polo-like kinase 1 (PLK1) in the GRASP65 N-terminal domain for which mutation to aspartic acid blocked tethering and alanine substitution prevented mitotic Golgi unlinking.	Aspartic Acid	129-142	polo like kinase 1	Homo sapiens	48-66
21094982-11	2011	The homogenous variant genotype of GSTO2 142 Asp/Asp was inversely associated with UC risk (OR=0.17; 95% CI, 0.03 - 0.88; p=0.03).	Aspartic Acid	45-48	glutathione S-transferase omega 2	Homo sapiens	35-40
21094982-11	2011	The homogenous variant genotype of GSTO2 142 Asp/Asp was inversely associated with UC risk (OR=0.17; 95% CI, 0.03 - 0.88; p=0.03).	Aspartic Acid	49-52	glutathione S-transferase omega 2	Homo sapiens	35-40
20961850-11	2010	Moreover, we find that phosphorylation of the catalytically important Asp residue in human P(4)-ATPases ATP8B1 and ATP8B2 is critically dependent on their CDC50 subunit.	Aspartic Acid	70-73	ATPase phospholipid transporting 8B1	Homo sapiens	104-110
20961850-11	2010	Moreover, we find that phosphorylation of the catalytically important Asp residue in human P(4)-ATPases ATP8B1 and ATP8B2 is critically dependent on their CDC50 subunit.	Aspartic Acid	70-73	ATPase phospholipid transporting 8B2	Homo sapiens	115-121
20695776-3	2011	During tissue development, repair, and regeneration of epithelial tissues, cells must interact with an interstitial fibronectin (Fn)-rich matrix, which has been shown to direct a more migratory/repair phenotype, presumably through interaction with Fn"s cell binding domain comprised of both synergy Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) sequences.	Aspartic Acid	339-342	fibronectin 1	Homo sapiens	116-127
21138269-15	2010	These changes are due to binding of a second inhibitor molecule that results in the displacement of H(4)B and the placement of the inhibitor pyridine group in position to serve as a Zn(2+) ligand together with Asp, His, and a chloride ion.	Aspartic Acid	210-213	H4 clustered histone 4	Homo sapiens	100-105
20937827-4	2010	However, we identified a site phosphorylated by Polo-like kinase 1 (PLK1) in the GRASP65 N-terminal domain for which mutation to aspartic acid blocked tethering and alanine substitution prevented mitotic Golgi unlinking.	Aspartic Acid	129-142	polo like kinase 1	Homo sapiens	68-72
20937827-4	2010	However, we identified a site phosphorylated by Polo-like kinase 1 (PLK1) in the GRASP65 N-terminal domain for which mutation to aspartic acid blocked tethering and alanine substitution prevented mitotic Golgi unlinking.	Aspartic Acid	129-142	golgi reassembly stacking protein 1	Homo sapiens	81-88
20805364-0	2010	Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.	Aspartic Acid	20-29	solute carrier family 46 member 1	Homo sapiens	81-85
20805364-0	2010	Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.	Aspartic Acid	20-29	solute carrier family 46 member 1	Homo sapiens	86-93
20805364-2	2010	The current study explored the roles of Asp residues in PCFT function.	Aspartic Acid	40-43	solute carrier family 46 member 1	Homo sapiens	56-60
21054786-9	2010	This low activity could be explained by the fact that PRTFDC1 has a Gly in the position of the proposed catalytic Asp of HPRT.	Aspartic Acid	114-117	phosphoribosyl transferase domain containing 1	Homo sapiens	54-61
21204315-13	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (e.g., vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	127-138
21204315-13	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (e.g., vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	140-150
20876530-7	2010	Here, we show that MccF detoxifies both intact and processed McC by cleaving an amide bond between the C-terminal aspartate and the nucleotide moiety.	Aspartic Acid	114-123	MccF	Escherichia coli	19-23
21219031-3	2010	Albumin nanoparticles conjugated with a truncated fragment of fibronectin containing the Arg-Gly-Asp domain were successfully patterned and used as templates to elicit adhesion and spreading of human mesenchymal stem cells and fibroblasts.	Aspartic Acid	97-100	fibronectin 1	Homo sapiens	62-73
21054786-9	2010	This low activity could be explained by the fact that PRTFDC1 has a Gly in the position of the proposed catalytic Asp of HPRT.	Aspartic Acid	114-117	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	121-125
21054786-10	2010	In PRTFDC1, a water molecule at the position of the aspartic acid side chain position in HPRT might be responsible for the low activity observed by acting as a weak base.	Aspartic Acid	52-65	phosphoribosyl transferase domain containing 1	Homo sapiens	3-10
21054786-10	2010	In PRTFDC1, a water molecule at the position of the aspartic acid side chain position in HPRT might be responsible for the low activity observed by acting as a weak base.	Aspartic Acid	52-65	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	89-93
20919753-8	2010	The docking studies show binding of BH3 domain at Lys 110, Trp-111, Pro-115, Glu-119 and Asp-127 in the groove of BH 1, 2 and 3 domains of Bcl-2L10.	Aspartic Acid	89-92	BCL2 like 10	Homo sapiens	139-147
20886638-0	2010	The clinical spectrum of missense mutations of the first aspartic acid of cbEGF-like domains in fibrillin-1 including a recessive family.	Aspartic Acid	57-70	fibrillin 1	Homo sapiens	96-107
20886638-4	2010	In 9 index cases referred for MFS we detected heterozygous missense mutations in FBN1 predicted to substitute the first aspartic acid of different calcium-binding Epidermal Growth Factor-like (cbEGF) fibrillin-1 domains.	Aspartic Acid	120-133	fibrillin 1	Homo sapiens	81-85
20845493-7	2010	Modification of the CPC with arginine and aspartic acid, but not with cocarboxylase, led to a higher BMP-2 binding.	Aspartic Acid	42-55	bone morphogenetic protein 2	Homo sapiens	101-106
21058708-2	2010	Aspartate aminotransferase (AAT) is a prototypical PLP-dependent enzyme that catalyzes the reversible interconversion of aspartate and alpha-ketoglutarate with oxalacetate and glutamate.	Aspartic Acid	121-130	pyridoxal phosphatase	Homo sapiens	51-54
21058708-5	2010	Blue light (250 mW) illumination gives an observed 2.3-fold rate enhancement for WT AAT activity, a 530-fold enhancement for the inactive K258A mutant, and a 58600-fold enhancement for the PLP-Asp Schiff base in water.	Aspartic Acid	193-196	pyridoxal phosphatase	Homo sapiens	189-192
20956561-9	2010	Importantly, the interaction between Aly2 and Dip5 is accelerated in response to elevated aspartic acid availability.	Aspartic Acid	90-103	Aly2p	Saccharomyces cerevisiae S288C	37-41
20673702-1	2010	Aspartoacylase (ASPA) converts N-acetylaspartic acid into aspartate and acetate.	Aspartic Acid	58-67	aspartoacylase	Homo sapiens	0-14
20673702-1	2010	Aspartoacylase (ASPA) converts N-acetylaspartic acid into aspartate and acetate.	Aspartic Acid	58-67	aspartoacylase	Homo sapiens	16-20
20956561-9	2010	Importantly, the interaction between Aly2 and Dip5 is accelerated in response to elevated aspartic acid availability.	Aspartic Acid	90-103	Dip5p	Saccharomyces cerevisiae S288C	46-50
21154330-3	2010	Single nucleotide polymorphisms of + 104T/C in rs143383 of the growth differentiation factor 5 (GDF5) gene and the aspartic acid repeat polymorphism of the asporin gene ASPN were genotyped by taqman probe and polyacrylamide gel electrophoresis respectively.	Aspartic Acid	115-128	asporin	Homo sapiens	156-163
21154330-3	2010	Single nucleotide polymorphisms of + 104T/C in rs143383 of the growth differentiation factor 5 (GDF5) gene and the aspartic acid repeat polymorphism of the asporin gene ASPN were genotyped by taqman probe and polyacrylamide gel electrophoresis respectively.	Aspartic Acid	115-128	asporin	Homo sapiens	169-173
20843813-6	2010	Our results also suggested the involvement of the canonical carboxylate residue Asp(228) acting as general base in the reaction catalyzed by human beta4GalT7.	Aspartic Acid	80-83	beta-1,4-galactosyltransferase 7	Homo sapiens	147-157
20971063-5	2010	ADAM28 cleaved CTGF in dose- and time-dependent manners at the Ala(181)-Tyr(182) and Asp(191)-Pro(192) bonds in the hinge region of the molecule.	Aspartic Acid	85-88	ADAM metallopeptidase domain 28	Homo sapiens	0-6
20870721-6	2010	Furthermore, mutation of the two serines in beta4 to phospho-mimicking aspartic acid decreased its interaction with the cytoskeletal linker protein plectin, as well as the strength of alpha6beta4-mediated adhesion to laminin-332.	Aspartic Acid	71-84	tubulin beta 3 class III	Homo sapiens	44-49
20870721-6	2010	Furthermore, mutation of the two serines in beta4 to phospho-mimicking aspartic acid decreased its interaction with the cytoskeletal linker protein plectin, as well as the strength of alpha6beta4-mediated adhesion to laminin-332.	Aspartic Acid	71-84	plectin	Homo sapiens	148-155
20971063-5	2010	ADAM28 cleaved CTGF in dose- and time-dependent manners at the Ala(181)-Tyr(182) and Asp(191)-Pro(192) bonds in the hinge region of the molecule.	Aspartic Acid	85-88	cellular communication network factor 2	Homo sapiens	15-19
20977208-2	2010	Numerous structure-activity relationship studies have identified Asp(1), Arg(2), and His(6) of Ang II to be critical for its biological activity and receptor binding.	Aspartic Acid	65-68	angiogenin	Homo sapiens	95-98
20964433-3	2010	This was approached by fusion sesame oleosin (Ole), the primary membrane protein of seed oil bodies, with a small domain consisting of the arginine-glycine-aspartic acid (RGD) motif.	Aspartic Acid	156-169	oleosin H1	Sesamum indicum	37-44
21081096-3	2010	However, subtle residue motions can be distinguished, specifically of His(329) and Asp(330) to assemble in pol mu"s active site, and of Gln(440) and Glu(443) to help accommodate the incoming nucleotide.	Aspartic Acid	83-86	DNA polymerase mu	Homo sapiens	107-113
20977208-5	2010	In the reaction with ONE, a pyruvamide-Ang II that formed via oxidative decarboxylation of N-terminal Asp was detected as the most abundant product after 48 h of incubation.	Aspartic Acid	102-105	angiogenin	Homo sapiens	39-42
20977208-14	2010	Such stable ONE- and HNE-derived modifications to Ang II could potentially modulate its functions in vivo by disrupting the interaction with Ang II type 1 (AT(1)) receptor and/or inhibiting the enzyme activity of aminopeptidase A (APA), which cleaves the N-terminal Asp residue of Ang II to generate Ang III.	Aspartic Acid	266-269	angiogenin	Homo sapiens	50-53
20977208-14	2010	Such stable ONE- and HNE-derived modifications to Ang II could potentially modulate its functions in vivo by disrupting the interaction with Ang II type 1 (AT(1)) receptor and/or inhibiting the enzyme activity of aminopeptidase A (APA), which cleaves the N-terminal Asp residue of Ang II to generate Ang III.	Aspartic Acid	266-269	glutamyl aminopeptidase	Homo sapiens	213-229
21085684-2	2010	Two classical PLDs, PLD1 and PLD2, contain phosphatidylinositide-binding PX and PH domains and two conserved His-x-Lys-(x)(4)-Asp (HKD) motifs, which are critical for PLD activity.	Aspartic Acid	126-129	phospholipase D1	Mus musculus	20-24
30532829-7	2011	Polymerase chain reaction (PCR) and sequencing of the PCR product showed a heterozygous missense mutation of codon 85 in the COL3A1 gene, which converted glycine to aspartic acid, and thus a diagnosis of EDS type IV was established.	Aspartic Acid	165-178	collagen type III alpha 1 chain	Homo sapiens	125-131
21085684-2	2010	Two classical PLDs, PLD1 and PLD2, contain phosphatidylinositide-binding PX and PH domains and two conserved His-x-Lys-(x)(4)-Asp (HKD) motifs, which are critical for PLD activity.	Aspartic Acid	126-129	phospholipase D2	Mus musculus	29-33
20974977-3	2010	Computational and biological analyses of the IL-27 binding site 1 to its receptor revealed important structural proximities with the ciliary neurotrophic factor group of cytokines and highlighted the contribution of p28 Trp(97), as well as of EBI3 Phe(97), Asp(210), and Glu(159), as key residues in the interactions between both cytokine subunits.	Aspartic Acid	257-260	interleukin 27	Mus musculus	45-50
20859969-1	2010	Treatment of AsP(3) with 0.75 equivalents of [{GaC(SiMe(3))(3)}(4)] resulted in selective insertion of three equivalents of {GaC(SiMe(3))(3)} into the three As--P bonds to give [As{GaC(SiMe(3))(3)}(3)P(3)] (1-As) with an intact cyclo-P(3) ring.	Aspartic Acid	13-16	exosome component 10	Homo sapiens	200-204
20934468-5	2010	Here we fused the elastin derived peptide Ala-Pro-Gly-Val-Gly-Val (APGVGV) with the cell adhesive peptides, Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD).	Aspartic Acid	148-151	elastin	Homo sapiens	18-25
20633015-1	2010	BACKGROUND AND PURPOSE: The present work aimed to investigate whether and through which mechanisms selective alpha7 and alpha4beta2 nicotinic receptor (nAChR) agonists stimulate endogenous glutamate (GLU) and aspartate (ASP) release in rat hippocampus.	Aspartic Acid	209-218	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	152-157
20633015-1	2010	BACKGROUND AND PURPOSE: The present work aimed to investigate whether and through which mechanisms selective alpha7 and alpha4beta2 nicotinic receptor (nAChR) agonists stimulate endogenous glutamate (GLU) and aspartate (ASP) release in rat hippocampus.	Aspartic Acid	220-223	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	152-157
20633015-9	2010	CONCLUSIONS AND IMPLICATIONS: Our study shows for the first time that rat hippocampal synaptosomes possess alpha7 and alpha4beta2 nAChR subtypes, which can enhance the release of endogenous GLU and ASP via two distinct mechanisms of action.	Aspartic Acid	198-201	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	130-135
20667434-0	2010	Interaction of bovine serum albumin and albumin-gold nanoconjugates with l-aspartic acid.	Aspartic Acid	73-88	albumin	Homo sapiens	22-35
20667434-2	2010	The interaction of an essential transport protein bovine serum albumin (BSA) and albumin-gold nanoconjugates (BSA-GNPs) with amino acid l-aspartic (ASP) are investigated by steady state and time resolved spectroscopic techniques.	Aspartic Acid	148-151	albumin	Homo sapiens	57-70
20890311-5	2010	We demonstrate biochemically that intramolecular cleavage at Asp 193 is a prerequisite for CASP6 self-activation and that this activation mechanism is dependent on the length of the L2 loop.	Aspartic Acid	61-64	caspase 6	Homo sapiens	91-96
21079777-8	2010	Indeed, changing this histidine in CFP into an aspartic acid results in identical fluorescence properties as observed for the Cerulean fluorescent based FRET sensor.	Aspartic Acid	47-60	complement factor properdin	Homo sapiens	35-38
20720179-7	2010	We were surprised to find that amino acid substitutions at Thr-10 and Asp-12 significantly enhanced the ability of PLM to modulate Ca(V)1.2 gating.	Aspartic Acid	70-73	FXYD domain containing ion transport regulator 1	Homo sapiens	115-118
20720179-7	2010	We were surprised to find that amino acid substitutions at Thr-10 and Asp-12 significantly enhanced the ability of PLM to modulate Ca(V)1.2 gating.	Aspartic Acid	70-73	immunoglobulin lambda variable 2-8	Homo sapiens	131-139
20978199-1	2010	Aspartate-594 is the third most common BRAF residue mutated in human cancer.	Aspartic Acid	0-9	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	39-43
20643175-3	2010	Using semi-quantitative Western blotting and an ex vivo D-[(3)H]-aspartate uptake assay, we showed a time-dependent bilateral effect of unilateral 6-hydroxydopamine lesioning on the expression as well as activity of GLT-1.	Aspartic Acid	65-74	solute carrier family 1 member 2	Rattus norvegicus	216-221
20702624-3	2010	Here, we describe a virus with a rare mutation at position 179 in the V2 domain of gp120, where replacement of aspartic acid (D) by asparagine (N) converts a virus that is highly resistant to neutralization by multiple polyclonal and monoclonal antibodies, as well as antiviral entry inhibitors, to one that is sensitive to neutralization.	Aspartic Acid	111-124	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	83-88
20807208-7	2010	Vitronectin has an Arg-Gly-Asp (RGD) sequence for binding the host cell integrin receptors and a separate bacterial-binding domain for pathogens, and thus more likely functions to cross-link bacteria and epithelial cells.	Aspartic Acid	27-30	vitronectin	Homo sapiens	0-11
21055617-0	2010	Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging.	Aspartic Acid	31-34	proopiomelanocortin	Homo sapiens	46-82
21055617-1	2010	INTRODUCTION: The purpose of this study was to examine whether (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide targeting both melanocortin-1 (MC1) and alpha(v)beta(3) integrin receptors was superior in melanoma targeting to (99m)Tc-labeled alpha-MSH or RGD peptide targeting only the MC1 or alpha(v)beta(3) integrin receptor.	Aspartic Acid	87-90	proopiomelanocortin	Homo sapiens	108-144
21055617-1	2010	INTRODUCTION: The purpose of this study was to examine whether (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide targeting both melanocortin-1 (MC1) and alpha(v)beta(3) integrin receptors was superior in melanoma targeting to (99m)Tc-labeled alpha-MSH or RGD peptide targeting only the MC1 or alpha(v)beta(3) integrin receptor.	Aspartic Acid	87-90	proopiomelanocortin	Homo sapiens	146-155
21055617-1	2010	INTRODUCTION: The purpose of this study was to examine whether (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide targeting both melanocortin-1 (MC1) and alpha(v)beta(3) integrin receptors was superior in melanoma targeting to (99m)Tc-labeled alpha-MSH or RGD peptide targeting only the MC1 or alpha(v)beta(3) integrin receptor.	Aspartic Acid	87-90	proopiomelanocortin	Homo sapiens	301-310
20300803-1	2010	PURPOSE: A reversibly-PEGylated diblock copolymer, poly(aspartate-hydrazide-poly(ethylene glycol))-block-poly(aspartate-diaminoethane) (p[Asp(Hyd-PEG)]-b-p[Asp(DET)]) was reported here for enhanced gene transfection and colloidal stability.	Aspartic Acid	138-141	progestagen associated endometrial protein	Homo sapiens	22-25
20300803-4	2010	METHODS: p[Asp(Hyd-PEG)]-b-p[Asp(DET)] was synthesized and characterized by (1)H-NMR.	Aspartic Acid	11-14	progestagen associated endometrial protein	Homo sapiens	19-22
20300803-4	2010	METHODS: p[Asp(Hyd-PEG)]-b-p[Asp(DET)] was synthesized and characterized by (1)H-NMR.	Aspartic Acid	29-32	progestagen associated endometrial protein	Homo sapiens	19-22
21061495-2	2004	Ligands such as vitronectin, fibronectin, etc., which interact with integrins, are known to bind these receptors through an Arg-Gly-Asp (RGD) epitope.	Aspartic Acid	132-135	vitronectin	Homo sapiens	16-27
21061495-2	2004	Ligands such as vitronectin, fibronectin, etc., which interact with integrins, are known to bind these receptors through an Arg-Gly-Asp (RGD) epitope.	Aspartic Acid	132-135	fibronectin 1	Homo sapiens	29-40
20979597-6	2010	As only TIP39 causes internalisation of the receptor and the primary difference being an aspartic acid in position 7 of TIP39 that interacts with histidine 396 in the receptor, versus isoleucine/histidine residues in the related hormones, this might be a trigger interaction for the events that cause internalisation.	Aspartic Acid	89-102	parathyroid hormone 2	Homo sapiens	8-13
20979597-6	2010	As only TIP39 causes internalisation of the receptor and the primary difference being an aspartic acid in position 7 of TIP39 that interacts with histidine 396 in the receptor, versus isoleucine/histidine residues in the related hormones, this might be a trigger interaction for the events that cause internalisation.	Aspartic Acid	89-102	parathyroid hormone 2	Homo sapiens	120-125
20979597-7	2010	CONCLUSIONS: A model is constructed for the complex and a trigger interaction for full agonistic activation between aspartic acid 7 of TIP39 and histidine 396 in the receptor is proposed.	Aspartic Acid	116-129	parathyroid hormone 2	Homo sapiens	135-140
20480190-15	2010	MEN1 gene analysis revealed one somatic missense mutation at exon 2, codon 121, GTC (Val) to GAC (Asp) in one patient.	Aspartic Acid	98-101	menin 1	Homo sapiens	0-4
20828134-10	2010	These results are in contrast to plant specific Crys represented by Arabidopsis thaliana Cry1 that carry Asp at the position.	Aspartic Acid	105-108	cryptochrome 1	Arabidopsis thaliana	89-93
20670938-7	2010	hadh(-/-) islets have lower intracellular glutamate and aspartate levels, and this decrease can be prevented by high glucose.	Aspartic Acid	56-65	hydroxyacyl-Coenzyme A dehydrogenase	Mus musculus	0-4
20921115-3	2010	OBJECTIVE: To examine epistasis between NRG1 and selected N-methyl-d-aspartate-glutamate pathway partners implicated in its effects, including ERBB4, AKT1, DLG4, NOS1, and NOS1AP.	Aspartic Acid	69-78	neuregulin 1	Homo sapiens	40-44
20679349-6	2010	Alanine substitution for Tyr-198, Leu-199, or Val-204 abrogates the ability of p67(phox) to support superoxide production by gp91(phox)-based oxidase as well as its related oxidases Nox1 and Nox3; the activation also involves other invariant residues such as Leu-193, Asp-197, and Gly-200.	Aspartic Acid	268-271	CD33 molecule	Homo sapiens	79-82
20679349-6	2010	Alanine substitution for Tyr-198, Leu-199, or Val-204 abrogates the ability of p67(phox) to support superoxide production by gp91(phox)-based oxidase as well as its related oxidases Nox1 and Nox3; the activation also involves other invariant residues such as Leu-193, Asp-197, and Gly-200.	Aspartic Acid	268-271	CD33 molecule	Homo sapiens	83-87
20679349-6	2010	Alanine substitution for Tyr-198, Leu-199, or Val-204 abrogates the ability of p67(phox) to support superoxide production by gp91(phox)-based oxidase as well as its related oxidases Nox1 and Nox3; the activation also involves other invariant residues such as Leu-193, Asp-197, and Gly-200.	Aspartic Acid	268-271	CD33 molecule	Homo sapiens	130-134
20367116-2	2010	DPP, the most abundant of the noncollagenous proteins (NCPs) in dentin is an unusually polyanionic protein, containing a large number of aspartic acids (Asp) and phosphoserines (Pse) in the repeating sequences of (Asp-Pse)(n).	Aspartic Acid	137-151	dentin sialophosphoprotein	Homo sapiens	0-3
20482929-0	2010	The casein peptide Asn-Pro-Trp-Asp-Gln enforces the intestinal tight junction partly by increasing occludin expression in Caco-2 cells.	Aspartic Acid	31-34	occludin	Homo sapiens	99-107
20643479-2	2010	Here, we focused on integrin-mediated cell-scaffold adhesion and prepared cell adhesive fibroin in which a tandem repeat of the Arg-Gly-Asp-Ser (RGDS) sequence was genetically interfused in the fibroin light chain (L-chain) (L-RGDSx2 fibroin).	Aspartic Acid	136-139	ral guanine nucleotide dissociation stimulator	Homo sapiens	145-149
20367116-2	2010	DPP, the most abundant of the noncollagenous proteins (NCPs) in dentin is an unusually polyanionic protein, containing a large number of aspartic acids (Asp) and phosphoserines (Pse) in the repeating sequences of (Asp-Pse)(n).	Aspartic Acid	153-156	dentin sialophosphoprotein	Homo sapiens	0-3
20688915-8	2010	Rat SYT4 was able to stimulate fusion in response to Ca(2+) when the conserved Asp-to-Ser Ca(2+) ligand substitution in its C2A domain was reversed.	Aspartic Acid	79-82	synaptotagmin 4	Rattus norvegicus	4-8
20501796-5	2010	In extracellular solutions rich in Cl(-) or Br(-), CLC-5 exhibited a gating charge of 1.3, but this was reduced to 0.9 in solutions comprising the impermeant anions aspartate, methanesulfonate, sulfate, or HEPES.	Aspartic Acid	165-174	chloride voltage-gated channel 5	Homo sapiens	51-56
20660187-5	2010	Selected peptides showed partial identity with amino acids in the extracellular domains of CCR5/CXCR4, including motifs rich in tyrosines and aspartates at the N terminus known to be important for gp120 binding.	Aspartic Acid	142-152	C-C motif chemokine receptor 5	Homo sapiens	91-95
20945564-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Mus musculus	121-132
20702586-6	2010	Introduction of aspartic acid residues in place of either of these two sites in Nup1 bypassed the requirement for Cdk1 and resulted in targeting of INO1 and GAL1 to the nuclear periphery during S-phase.	Aspartic Acid	16-29	FG-nucleoporin NUP1	Saccharomyces cerevisiae S288C	80-84
20702586-6	2010	Introduction of aspartic acid residues in place of either of these two sites in Nup1 bypassed the requirement for Cdk1 and resulted in targeting of INO1 and GAL1 to the nuclear periphery during S-phase.	Aspartic Acid	16-29	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	114-118
20702586-6	2010	Introduction of aspartic acid residues in place of either of these two sites in Nup1 bypassed the requirement for Cdk1 and resulted in targeting of INO1 and GAL1 to the nuclear periphery during S-phase.	Aspartic Acid	16-29	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	148-152
20702586-6	2010	Introduction of aspartic acid residues in place of either of these two sites in Nup1 bypassed the requirement for Cdk1 and resulted in targeting of INO1 and GAL1 to the nuclear periphery during S-phase.	Aspartic Acid	16-29	galactokinase	Saccharomyces cerevisiae S288C	157-161
20931536-8	2010	RESULTS: Direct DNA sequence analysis identified a heterozygous 181G to A change in exon 3 of the PTPN11 gene in one patient, which resulted in the substitution of an aspartic acid residue by an asparagine at codon 61.	Aspartic Acid	167-180	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	98-104
20806954-9	2010	The hydrogen bonds formed between the INH peptide, residues Tyr1, Tyr3, and Leu7 with the BACE1 residues Leu267, Cys269, Trp270, Asp311, and Asp 317 can strengthen the binding of the BACE1-INH complex.	Aspartic Acid	129-132	beta-1,3-glucuronyltransferase 1	Homo sapiens	76-80
20806954-9	2010	The hydrogen bonds formed between the INH peptide, residues Tyr1, Tyr3, and Leu7 with the BACE1 residues Leu267, Cys269, Trp270, Asp311, and Asp 317 can strengthen the binding of the BACE1-INH complex.	Aspartic Acid	129-132	beta-secretase 1	Homo sapiens	90-95
20806954-9	2010	The hydrogen bonds formed between the INH peptide, residues Tyr1, Tyr3, and Leu7 with the BACE1 residues Leu267, Cys269, Trp270, Asp311, and Asp 317 can strengthen the binding of the BACE1-INH complex.	Aspartic Acid	129-132	beta-secretase 1	Homo sapiens	183-188
20660187-5	2010	Selected peptides showed partial identity with amino acids in the extracellular domains of CCR5/CXCR4, including motifs rich in tyrosines and aspartates at the N terminus known to be important for gp120 binding.	Aspartic Acid	142-152	C-X-C motif chemokine receptor 4	Homo sapiens	96-101
20660187-5	2010	Selected peptides showed partial identity with amino acids in the extracellular domains of CCR5/CXCR4, including motifs rich in tyrosines and aspartates at the N terminus known to be important for gp120 binding.	Aspartic Acid	142-152	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	197-202
20818390-3	2010	Like the bacterial enzyme, Mesh1 proteins contain an active site for ppGpp hydrolysis and a conserved His-Asp-box motif for Mn(2+) binding.	Aspartic Acid	106-109	Metazoan SpoT homolog-1	Drosophila melanogaster	27-32
20728365-0	2010	Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide.	Aspartic Acid	138-141	pro-opiomelanocortin-alpha	Mus musculus	153-189
20628049-11	2010	Indeed, alanine mutation of either Arg(445) (helix 8) or Asp(498) (helix 10) abrogated T(3) transport activity of MCT8, supporting their predicted role in substrate recognition.	Aspartic Acid	57-60	solute carrier family 16 member 2	Homo sapiens	114-118
20463172-6	2010	Interestingly, downstream of the second threonine residue, we have identified a conserved aspartic acid residue which is critical for NKCC1 function.	Aspartic Acid	90-103	solute carrier family 12, member 2	Mus musculus	134-139
21305874-1	2010	L-asparaginase catalyzes the hydrolysis of L-asparagine into aspartate and ammonia, which is used as an anti-neoplastic agent.	Aspartic Acid	61-70	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
20463172-8	2010	We found that mutating the threonine residue into a glutamic acid (T243E) combined with mutation of the serine into an aspartic acid (S383D) rendered SPAK constitutively active.	Aspartic Acid	119-132	serine/threonine kinase 39	Mus musculus	150-154
20573782-5	2010	This cluster is expected to be altered upon VIP binding, because Arg(188) has been shown previously to interact with Asp(3) of VIP.	Aspartic Acid	117-120	vasoactive intestinal peptide	Homo sapiens	44-47
20557293-9	2010	The universally conserved aspartate residue in the LeuRS CP1 domains was responsible for the resistance of GlLeuRS and another recently reported AN2690-resistant AaLeuRS (Aquifex aeolicus LeuRS).	Aspartic Acid	26-35	leucyl-tRNA synthetase 1	Homo sapiens	51-56
20557293-9	2010	The universally conserved aspartate residue in the LeuRS CP1 domains was responsible for the resistance of GlLeuRS and another recently reported AN2690-resistant AaLeuRS (Aquifex aeolicus LeuRS).	Aspartic Acid	26-35	leucyl-tRNA synthetase 1	Homo sapiens	109-114
20541849-4	2010	Dipeptidyl derivatives were significantly superior to their counterparts containing only Asp at P(1), as caspase-3 inhibitors.	Aspartic Acid	89-92	caspase 3	Homo sapiens	105-114
20210696-9	2010	No significant differences in any clinical or hormonal measures between subjects on the basis of genotype were observed, except the increased levels of fasting glucose that exhibit the carriers of the Asp allele of the IRS-2 polymorphism.	Aspartic Acid	201-204	insulin receptor substrate 2	Homo sapiens	219-224
20467051-9	2010	Our findings suggest that the T allele encoding for aspartic acid of the eNOS (Glu298Asp) gene may contribute to poor sperm motility.	Aspartic Acid	52-65	nitric oxide synthase 3	Homo sapiens	73-77
20542645-6	2010	The distribution of pregnancy complications and fetal disorders differed between preterm birth groups: ischemic placental diseases were present in 38,2 % of medically-indicated births; preterm premature rupture of membranes occurred twice more often in I and ASp preterm births than in NASp preterm births.	Aspartic Acid	259-262	nuclear autoantigenic sperm protein	Homo sapiens	286-290
20626561-2	2010	We now report the effects of the arginine-glycine-aspartic acid (RGD)-containing peptide fragment of OPN and OPN inactivation on the survival of tyrosine hydroxylase (TH) positive neurones in primary rat ventral mesencephalic (VM) cultures and in SN in the rat.	Aspartic Acid	50-63	secreted phosphoprotein 1	Rattus norvegicus	101-104
20685300-1	2010	Missense PTEN mutations of the active site residues Asp-92, Cys-124 and Gly-129 contribute to Cowden syndrome.	Aspartic Acid	52-55	phosphatase and tensin homolog	Homo sapiens	9-13
20685300-8	2010	The results also imply that allosteric regulators facilitating the recruitment of Asp-92 to participate in catalysis will increase the activity of PTEN in dephosphorylating phosphoprotein and phosphopeptide substrates.	Aspartic Acid	82-85	phosphatase and tensin homolog	Homo sapiens	147-151
20491958-4	2010	Replacement respectively of the hydrophilic Asp residue with hydrophobic positively charged His and of the hydrophobic neutral Val residue with the Asp residue most likely disrupts the MCFD2-LMAN1 interaction, thus leading to the disease phenotype.	Aspartic Acid	44-47	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	Homo sapiens	185-190
20491958-4	2010	Replacement respectively of the hydrophilic Asp residue with hydrophobic positively charged His and of the hydrophobic neutral Val residue with the Asp residue most likely disrupts the MCFD2-LMAN1 interaction, thus leading to the disease phenotype.	Aspartic Acid	44-47	lectin, mannose binding 1	Homo sapiens	191-196
20491958-4	2010	Replacement respectively of the hydrophilic Asp residue with hydrophobic positively charged His and of the hydrophobic neutral Val residue with the Asp residue most likely disrupts the MCFD2-LMAN1 interaction, thus leading to the disease phenotype.	Aspartic Acid	148-151	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	Homo sapiens	185-190
20491958-4	2010	Replacement respectively of the hydrophilic Asp residue with hydrophobic positively charged His and of the hydrophobic neutral Val residue with the Asp residue most likely disrupts the MCFD2-LMAN1 interaction, thus leading to the disease phenotype.	Aspartic Acid	148-151	lectin, mannose binding 1	Homo sapiens	191-196
20883264-7	2010	The aspartic acid residue at the mutation site is located in the C-terminal portion of the second a-helix strand, a2, of N-terminal four helices of FALDH and the FALDH amino-acid sequence alignment shows that this aspartic acid residue is conserved among several diverse species.	Aspartic Acid	4-17	aldehyde dehydrogenase 3 family member A2	Homo sapiens	148-153
20883264-7	2010	The aspartic acid residue at the mutation site is located in the C-terminal portion of the second a-helix strand, a2, of N-terminal four helices of FALDH and the FALDH amino-acid sequence alignment shows that this aspartic acid residue is conserved among several diverse species.	Aspartic Acid	4-17	aldehyde dehydrogenase 3 family member A2	Homo sapiens	162-167
20883264-7	2010	The aspartic acid residue at the mutation site is located in the C-terminal portion of the second a-helix strand, a2, of N-terminal four helices of FALDH and the FALDH amino-acid sequence alignment shows that this aspartic acid residue is conserved among several diverse species.	Aspartic Acid	214-227	aldehyde dehydrogenase 3 family member A2	Homo sapiens	148-153
20883264-7	2010	The aspartic acid residue at the mutation site is located in the C-terminal portion of the second a-helix strand, a2, of N-terminal four helices of FALDH and the FALDH amino-acid sequence alignment shows that this aspartic acid residue is conserved among several diverse species.	Aspartic Acid	214-227	aldehyde dehydrogenase 3 family member A2	Homo sapiens	162-167
20573782-5	2010	This cluster is expected to be altered upon VIP binding, because Arg(188) has been shown previously to interact with Asp(3) of VIP.	Aspartic Acid	117-120	vasoactive intestinal peptide	Homo sapiens	127-130
20696886-5	2010	Although the aspartate-glutamate-alanine-histidine box motif (DEAH) domain of DHX36 was essential for CpG-A binding, the domain of unknown function 1605 (DUF1605 domain) of DHX9 was required for CpG-B binding.	Aspartic Acid	13-22	DEAH-box helicase 36	Homo sapiens	78-83
20669962-3	2010	The two active site aspartate residues containing BACE2 catalyze this reaction with 5.0 kcal/mol higher barrier than MMP.	Aspartic Acid	20-29	beta-secretase 2	Homo sapiens	50-55
20525688-3	2010	The functional role of Asp(340) in Hxt7, the residue corresponding to Asn(331) of Hxt2, was examined by replacing it with each of the other 19 amino acids.	Aspartic Acid	23-26	hexose transporter HXT7	Saccharomyces cerevisiae S288C	35-39
20696886-4	2010	CpG-A selectively bound the aspartate-glutamate-any amino acid-aspartate/histidine (DExD/H)-box helicase 36 (DHX36), whereas CpG-B selectively bound DExD/H-box helicase 9 (DHX9).	Aspartic Acid	28-37	DEAH-box helicase 36	Homo sapiens	109-114
20696886-4	2010	CpG-A selectively bound the aspartate-glutamate-any amino acid-aspartate/histidine (DExD/H)-box helicase 36 (DHX36), whereas CpG-B selectively bound DExD/H-box helicase 9 (DHX9).	Aspartic Acid	63-72	DEAH-box helicase 36	Homo sapiens	109-114
20525688-3	2010	The functional role of Asp(340) in Hxt7, the residue corresponding to Asn(331) of Hxt2, was examined by replacing it with each of the other 19 amino acids.	Aspartic Acid	23-26	hexose transporter HXT2	Saccharomyces cerevisiae S288C	82-86
20525688-4	2010	Such replacement of Asp(340) generated transporters with various affinities for glucose, with the affinity of the Cys(340) mutant surpassing that of the wild-type Hxt7.	Aspartic Acid	20-23	hexose transporter HXT7	Saccharomyces cerevisiae S288C	163-167
20525688-6	2010	The transport activity of the D340C mutant of Cys-less Hxt7, in which Asp(340) is replaced with Cys, was completely inhibited by pCMBS, indicating that Asp(340) is located in a water-accessible position.	Aspartic Acid	70-73	hexose transporter HXT7	Saccharomyces cerevisiae S288C	55-59
20525688-8	2010	These results indicate that Asp(340) is situated at or close to a substrate recognition site and is a key residue determining high-affinity glucose transport by Hxt7, supporting the notion that yeast glucose transporters share a common mechanism for substrate recognition.	Aspartic Acid	28-31	hexose transporter HXT7	Saccharomyces cerevisiae S288C	161-165
20561531-8	2010	These structural changes limit high-affinity interactions for SPSB2 to aspartate-containing sequences, whereas SPSB1 and SPSB4 bind strongly to both Par-4 and VASA peptides.	Aspartic Acid	71-80	splA/ryanodine receptor domain and SOCS box containing 2	Homo sapiens	62-67
20581062-3	2010	The objective of our work was to determine whether PHEX impairment induces MEPE cleavage in dentin and the subsequent release of the C-terminal acidic serine- and aspartate-rich motif (ASARM) peptide, which is known to inhibit mineralization.	Aspartic Acid	163-172	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	51-55
20637637-4	2010	Whereas, H-Dmt-Tic-Asp *-Bid is a potent and selective delta agonist (MVD, IC(50)=0.12nM); H-Dft-Tic-Asp *-Bid and H-Tyr-Tic-Asp *-Bid are potent and selective delta antagonists (pA(2)=8.95 and 8.85, respectively).	Aspartic Acid	19-22	BH3 interacting domain death agonist	Homo sapiens	25-28
20637637-4	2010	Whereas, H-Dmt-Tic-Asp *-Bid is a potent and selective delta agonist (MVD, IC(50)=0.12nM); H-Dft-Tic-Asp *-Bid and H-Tyr-Tic-Asp *-Bid are potent and selective delta antagonists (pA(2)=8.95 and 8.85, respectively).	Aspartic Acid	19-22	BH3 interacting domain death agonist	Homo sapiens	107-110
20637637-4	2010	Whereas, H-Dmt-Tic-Asp *-Bid is a potent and selective delta agonist (MVD, IC(50)=0.12nM); H-Dft-Tic-Asp *-Bid and H-Tyr-Tic-Asp *-Bid are potent and selective delta antagonists (pA(2)=8.95 and 8.85, respectively).	Aspartic Acid	19-22	BH3 interacting domain death agonist	Homo sapiens	107-110
20637637-4	2010	Whereas, H-Dmt-Tic-Asp *-Bid is a potent and selective delta agonist (MVD, IC(50)=0.12nM); H-Dft-Tic-Asp *-Bid and H-Tyr-Tic-Asp *-Bid are potent and selective delta antagonists (pA(2)=8.95 and 8.85, respectively).	Aspartic Acid	18-22	BH3 interacting domain death agonist	Homo sapiens	25-28
20637637-4	2010	Whereas, H-Dmt-Tic-Asp *-Bid is a potent and selective delta agonist (MVD, IC(50)=0.12nM); H-Dft-Tic-Asp *-Bid and H-Tyr-Tic-Asp *-Bid are potent and selective delta antagonists (pA(2)=8.95 and 8.85, respectively).	Aspartic Acid	18-22	BH3 interacting domain death agonist	Homo sapiens	107-110
20637637-4	2010	Whereas, H-Dmt-Tic-Asp *-Bid is a potent and selective delta agonist (MVD, IC(50)=0.12nM); H-Dft-Tic-Asp *-Bid and H-Tyr-Tic-Asp *-Bid are potent and selective delta antagonists (pA(2)=8.95 and 8.85, respectively).	Aspartic Acid	18-22	BH3 interacting domain death agonist	Homo sapiens	107-110
20599753-12	2010	The active site of the catalytic domain of GBBH is similar to that of other 2KG oxygenases, and Fe(II)-binding residues form a conserved His-X-Asp-X(n)-His triad, which is found in all related enzymes.	Aspartic Acid	143-146	gamma-butyrobetaine hydroxylase 1	Homo sapiens	43-47
20484701-3	2010	IGF-I also significantly reduced the production of acid-soluble products (ASP) and the concentration of FA in the medium, while cellular triacylglycerols (TAG) tended to increase.	Aspartic Acid	74-77	insulin-like growth factor I	Oncorhynchus mykiss	0-5
20484701-7	2010	Rosiglitazone (a peroxisome proliferator-activated receptor gamma agonist) and etomoxir (a CPT-1 inhibitor) produced a severe and significant reduction in the production of CO(2) and ASP.	Aspartic Acid	183-186	peroxisome proliferator-activated receptor gamma	Oncorhynchus mykiss	17-65
20484701-7	2010	Rosiglitazone (a peroxisome proliferator-activated receptor gamma agonist) and etomoxir (a CPT-1 inhibitor) produced a severe and significant reduction in the production of CO(2) and ASP.	Aspartic Acid	183-186	carnitine palmitoyl transferase I	Oncorhynchus mykiss	91-96
20620068-5	2010	The most effective BACE 1 inhibitor 9f (27.85+/-2.46 micromol/L) was selected for further receptor-binding studies, the result of which indicated that an essential hydrogen bonds was formed between the urea group of 9f and the catalytic aspartate Asp228.	Aspartic Acid	237-246	beta-secretase 1	Homo sapiens	19-25
20715989-2	2010	USP17 has highly conserved Cys, His, and Asp domains responsible for the deubiquitinating activity, and two hyaluronan binding motifs in its sequence.	Aspartic Acid	41-44	ubiquitin specific peptidase 17 like family member 9, pseudogene	Homo sapiens	0-5
20649595-9	2010	While this selectivity was not observed at hGLP-1R, it was regained when Glu-68 of hGLP-1R was mutated to Asp.	Aspartic Acid	106-109	glucagon like peptide 1 receptor	Homo sapiens	83-90
20649595-11	2010	A hydrogen bond between Ser32 of Ex4 and Asp-68 of rGLP-1R, which is not formed with Glu-68 of hGLP-1R, is responsible for the improved affinity of Ex4 at the rat receptor.	Aspartic Acid	41-44	glucagon-like peptide 1 receptor	Rattus norvegicus	51-58
20402667-2	2010	Here, we have characterized a novel USP44 (ubiquitin-specific protease 44), which has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes.	Aspartic Acid	194-207	ubiquitin specific peptidase 44	Mus musculus	36-41
20402667-2	2010	Here, we have characterized a novel USP44 (ubiquitin-specific protease 44), which has a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes.	Aspartic Acid	194-207	ubiquitin specific peptidase 44	Mus musculus	43-73
20524964-0	2010	Real-time, spatially resolved analysis of serotonin transporter activity and regulation using the fluorescent substrate, ASP+.	Aspartic Acid	121-125	solute carrier family 6 member 4	Homo sapiens	42-63
20524964-4	2010	4-(4-(dimethylamino)-styryl)-N-methylpyridinium (ASP(+)) is a fluorescent monoamine transporter substrate that has been used for real-time monitoring of dopamine and norepinephrine transporter function in single cells.	Aspartic Acid	49-55	solute carrier family 6 member 2	Homo sapiens	166-192
20524964-5	2010	The present live cell imaging studies examine the utility of ASP(+) for quantifying human SERT function in HEK293 and neuroblastoma cells.	Aspartic Acid	61-64	solute carrier family 6 member 4	Homo sapiens	90-94
20524964-6	2010	We show rapid membrane binding and intracellular ASP(+) accumulation in human SERT-expressing cells.	Aspartic Acid	49-55	solute carrier family 6 member 4	Homo sapiens	78-82
20549504-3	2010	We detected ubiquitous USP32 expression across tissues and confirmed the predicted deubiquitination function owing to the presence of conserved peptidase signature aspargine, cysteine, histidine, and aspartic acid domains of ubiquitin-specific proteases.	Aspartic Acid	200-213	ubiquitin specific peptidase 32	Homo sapiens	23-28
20799012-5	2010	A mutated GIP peptide in which Tyr(1), Ile(7), Asp(15), and His(18) were replaced by His, Thr, Glu, and Ala, respectively, was able to activate both GLP1R and GIPR with moderate potency.	Aspartic Acid	47-50	gastric inhibitory polypeptide	Homo sapiens	10-13
20799012-5	2010	A mutated GIP peptide in which Tyr(1), Ile(7), Asp(15), and His(18) were replaced by His, Thr, Glu, and Ala, respectively, was able to activate both GLP1R and GIPR with moderate potency.	Aspartic Acid	47-50	glucagon like peptide 1 receptor	Homo sapiens	149-154
20519505-0	2010	A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).	Aspartic Acid	12-21	solute carrier family 1 member 6	Homo sapiens	83-118
20176108-4	2010	One mutant we have characterized is a catalytically inactive form of IKK-2, D145A IKK-2, wherein the catalytic aspartic acid, D145 was replaced with alanine.	Aspartic Acid	111-124	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	69-74
20176108-4	2010	One mutant we have characterized is a catalytically inactive form of IKK-2, D145A IKK-2, wherein the catalytic aspartic acid, D145 was replaced with alanine.	Aspartic Acid	111-124	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	82-87
20507979-0	2010	Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.	Aspartic Acid	0-3	epidermal growth factor receptor	Homo sapiens	68-100
20507979-11	2010	Our data are consistent with the hypothesis that Asp-960/Glu-961 represents a hinge or fulcrum for the movement of the C-terminal tail of the EGF receptor.	Aspartic Acid	49-52	epidermal growth factor receptor	Homo sapiens	142-154
20519505-0	2010	A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).	Aspartic Acid	12-21	solute carrier family 1 member 6	Homo sapiens	120-125
20519505-2	2010	Recently, a conserved aspartic acid (Asp(112)) within the intracellular loop near to the end of transmembrane domain 2 was proposed as a major determinant of substrate-dependent gating of the anion channel associated with the glial glutamate transporter EAAT1.	Aspartic Acid	22-35	solute carrier family 1 member 3	Homo sapiens	254-259
20519505-2	2010	Recently, a conserved aspartic acid (Asp(112)) within the intracellular loop near to the end of transmembrane domain 2 was proposed as a major determinant of substrate-dependent gating of the anion channel associated with the glial glutamate transporter EAAT1.	Aspartic Acid	37-40	solute carrier family 1 member 3	Homo sapiens	254-259
20662138-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Mus musculus	121-132
20480122-5	2010	Due to the incorporation of arginine-glycine-aspartic acid (RGD) sequences which could be specifically recognized by integrins alpha(upsilon)beta(3) and alpha(upsilon)beta(5) over-expressed on cancer cells, these lipopeptides could be specifically recognized by cancer cells, i.e. LP1 and LP2 exhibited relatively higher transfection efficiency in HeLa cell line than that of P2 and P3 without RGD sequence.	Aspartic Acid	45-58	ribosomal protein lateral stalk subunit P2	Homo sapiens	289-292
20557062-2	2010	We prepared conjugates of AuNPs and three isomer peptides capable of recognizing toxic aggregates of the amyloid beta protein (Abeta) involved in Alzheimer"s disease, namely, CLPFFD-CONH(2) (i0), CDLPFF-CONH(2) (i1), and CLPDFF-CONH(2) (i2), where D is the amino acid aspartic acid that is negatively charged at pH = 7.4.	Aspartic Acid	268-281	amyloid beta precursor protein	Homo sapiens	127-132
19784770-6	2010	Immunohistochemical examination of high-grade invasive ductal and lobular breast cancer with our polyclonal antibodies against a peptide (-Met-Ser-Ile-Tyr-Ser-Asp-Lys-Ser-Ile-His-) in the extracellular domain of the NMDAR1 receptor gave specific positive staining for the receptor in all 10 cases examined.	Aspartic Acid	159-162	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	216-222
20448042-4	2010	The N-methyl-D-aspartate (NMDA) receptor is composed of NR1 and NR2 subunits, which are activated by co-agonist glycine and glutamate or aspartate, respectively.	Aspartic Acid	15-24	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	56-59
20303335-4	2010	Solid-phase synthesis of cRGDyK (Arg-Gly-Asp-(D)Tyr-Lys) peptide and FAM-conjugated peptide were employed for binding to integrin alpha v beta 3.	Aspartic Acid	41-44	integrin subunit alpha V	Rattus norvegicus	121-137
20202478-7	2010	Several distinctive features of sea bass caspase-8 were identified, which include two death effector domains, the caspase family domains p20 and p10, the caspase-8 active-site pentapeptide and potential aspartic acid cleavage sites.	Aspartic Acid	203-216	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	32-35
20211725-7	2010	The mechanistic significance of phosphoMARCKS to motility was further established with a pseudo-phosphorylated mutant of MARCKS-GFP in which Asp residues replaced Ser residues known to be phosphorylated by PKC alpha.	Aspartic Acid	141-144	myristoylated alanine rich protein kinase C substrate	Mus musculus	39-45
23875515-7	2010	The rate of uptake was similar to that displayed by 4-(4-(dimethylamino)-styryl)-N-methylpyridinium (ASP+), a well established substrate for OCT and high-affinity Na+-dependent monoamine transporters.	Aspartic Acid	101-105	plexin A2	Homo sapiens	141-144
20645695-6	2010	The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains.	Aspartic Acid	110-113	acid phosphatase 3	Homo sapiens	20-23
20202478-7	2010	Several distinctive features of sea bass caspase-8 were identified, which include two death effector domains, the caspase family domains p20 and p10, the caspase-8 active-site pentapeptide and potential aspartic acid cleavage sites.	Aspartic Acid	203-216	caspase 8	Homo sapiens	41-50
20202478-7	2010	Several distinctive features of sea bass caspase-8 were identified, which include two death effector domains, the caspase family domains p20 and p10, the caspase-8 active-site pentapeptide and potential aspartic acid cleavage sites.	Aspartic Acid	203-216	caspase 8	Homo sapiens	41-48
20477940-8	2010	Moving the arginine residue from TM8 to HP1 in EAAT1 results in a transporter that has significantly increased affinity for both glutamate and aspartate and is K(+) independent.	Aspartic Acid	143-152	tetraspanin 16	Homo sapiens	33-36
19924428-0	2010	Aspartic acid racemisation in purified elastin from arteries as basis for age estimation.	Aspartic Acid	0-13	elastin	Homo sapiens	39-46
20232307-1	2010	Caspases are a conserved family of cell death proteases that cleave intracellular substrates at Asp residues to modify their function and promote apoptosis.	Aspartic Acid	96-99	caspase 1	Homo sapiens	0-8
20477940-8	2010	Moving the arginine residue from TM8 to HP1 in EAAT1 results in a transporter that has significantly increased affinity for both glutamate and aspartate and is K(+) independent.	Aspartic Acid	143-152	solute carrier family 1 member 3	Homo sapiens	47-52
20477940-9	2010	Conversely, moving the arginine residue from HP1 to TM8 in Glt(Ph) results in a transporter that has reduced affinity for aspartate.	Aspartic Acid	122-131	tetraspanin 16	Homo sapiens	52-55
20410266-0	2010	Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment?	Aspartic Acid	106-119	neuraminidase 1	Homo sapiens	0-13
20410266-3	2010	This was shown not to be due to an antigenic change in hemagglutinin (HA) but was shown to be the result of a mutation in aspartic acid 151 of neuraminidase (NA) to glycine, asparagine, or alanine, which caused an oseltamivir-sensitive agglutination of RBCs.	Aspartic Acid	122-135	neuraminidase 1	Homo sapiens	143-156
20410266-7	2010	It is apparent, however, that an important role of aspartic acid 151 in the activity of NA may be to restrict the specificity of the NA interaction and its receptor-destroying activity to complement that of HA receptor binding.	Aspartic Acid	51-64	neuraminidase 1	Homo sapiens	88-90
20410266-7	2010	It is apparent, however, that an important role of aspartic acid 151 in the activity of NA may be to restrict the specificity of the NA interaction and its receptor-destroying activity to complement that of HA receptor binding.	Aspartic Acid	51-64	neuraminidase 1	Homo sapiens	133-135
20410266-3	2010	This was shown not to be due to an antigenic change in hemagglutinin (HA) but was shown to be the result of a mutation in aspartic acid 151 of neuraminidase (NA) to glycine, asparagine, or alanine, which caused an oseltamivir-sensitive agglutination of RBCs.	Aspartic Acid	122-135	neuraminidase 1	Homo sapiens	158-160
20528251-9	2010	The ratio of Bcl-2/Bax protein decreased, and the percentage of activated caspase-3 increased in myeloma cells treated by matrine for 48 h, but this matrine-induced activity of caspase-3 was completely canceled by the addition of Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone (Z-DEVD-FMK), a caspase-3 inhibitor.	Aspartic Acid	232-235	caspase 3	Homo sapiens	177-186
20528251-9	2010	The ratio of Bcl-2/Bax protein decreased, and the percentage of activated caspase-3 increased in myeloma cells treated by matrine for 48 h, but this matrine-induced activity of caspase-3 was completely canceled by the addition of Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone (Z-DEVD-FMK), a caspase-3 inhibitor.	Aspartic Acid	232-235	caspase 3	Homo sapiens	177-186
20484411-8	2010	Conversely, phosphomimetic Asp substitution of these AD3 Ser/Thr residues enhanced activation by MINT.	Aspartic Acid	27-30	TBC1 domain family, member 8	Mus musculus	53-56
20385709-3	2010	BK-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) in mIMCD-3 cells was reduced by approximately 65% by synthetic peptides containing an Arg-Gly-Asp sequence, supporting roles for integrins in BK-induced signaling.	Aspartic Acid	176-179	mitogen-activated protein kinase 1	Mus musculus	30-75
20385709-3	2010	BK-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) in mIMCD-3 cells was reduced by approximately 65% by synthetic peptides containing an Arg-Gly-Asp sequence, supporting roles for integrins in BK-induced signaling.	Aspartic Acid	176-179	mitogen-activated protein kinase 1	Mus musculus	77-80
20484411-8	2010	Conversely, phosphomimetic Asp substitution of these AD3 Ser/Thr residues enhanced activation by MINT.	Aspartic Acid	27-30	spen family transcription repressor	Mus musculus	97-101
20406818-6	2010	Substitution of serine 8 in the CARD RIG-I functional domain with phosphomimetic aspartate or glutamate results in decreased TRIM25 binding, RIG-I ubiquitination, MAVS binding, and downstream signaling.	Aspartic Acid	81-90	DExD/H-box helicase 58	Homo sapiens	37-42
20562868-3	2010	We found that an aspartate to glycine substitution in the C(2)F domain of the synaptic vesicle protein otoferlin impaired hearing by reducing vesicle replenishment in the pachanga mouse model of human deafness DFNB9.	Aspartic Acid	17-26	otoferlin	Mus musculus	103-112
20104187-5	2010	Both forms of CK18 significantly correlated with degree of steatosis, lobular inflammation, and ballooning, and showed stronger positive correlations with NAS than serum aspartate and alanine aminotransferase (AST and ALT).	Aspartic Acid	170-179	keratin 18	Homo sapiens	14-18
20406818-6	2010	Substitution of serine 8 in the CARD RIG-I functional domain with phosphomimetic aspartate or glutamate results in decreased TRIM25 binding, RIG-I ubiquitination, MAVS binding, and downstream signaling.	Aspartic Acid	81-90	tripartite motif containing 25	Homo sapiens	125-131
20406818-6	2010	Substitution of serine 8 in the CARD RIG-I functional domain with phosphomimetic aspartate or glutamate results in decreased TRIM25 binding, RIG-I ubiquitination, MAVS binding, and downstream signaling.	Aspartic Acid	81-90	DExD/H-box helicase 58	Homo sapiens	141-146
20406818-6	2010	Substitution of serine 8 in the CARD RIG-I functional domain with phosphomimetic aspartate or glutamate results in decreased TRIM25 binding, RIG-I ubiquitination, MAVS binding, and downstream signaling.	Aspartic Acid	81-90	mitochondrial antiviral signaling protein	Homo sapiens	163-167
20565941-11	2010	The mobility of RCC1alpha on chromatin is increased by mutation of aspartate 182 (D182A), which inhibits guanine-nucleotide exchange activity, but RCC1alphaD182A can still bind nucleotide-free Ran and its interaction with chromatin is stabilised by RanT24N.	Aspartic Acid	67-76	regulator of chromosome condensation 1	Homo sapiens	16-20
20540760-4	2010	PRCP contains an alpha/beta hydrolase domain harboring the catalytic Asp-His-Ser triad and a novel helical structural domain that caps the active site.	Aspartic Acid	69-72	prolylcarboxypeptidase	Homo sapiens	0-4
20424163-6	2010	The enzyme protein L-isoaspartyl methyltransferase (PIMT) prevents isoaspartate accumulation by catalyzing the conversion of isoaspartates to aspartates.	Aspartic Acid	128-138	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	52-56
20368335-3	2010	Upon staurosporine treatment, a Cdc25A C-terminal 37-kDa fragment, designated C37, was generated by caspase cleavage at Asp-223.	Aspartic Acid	120-123	cell division cycle 25A	Homo sapiens	32-38
20498050-4	2010	K2P1-Lys274 is crucial: when mutated to Gln, Arg, Glu, Asp, Cys, or Ala, the channels are constitutively active and insensitive to SUMO1 and SENP1.	Aspartic Acid	55-58	potassium two pore domain channel subfamily K member 1	Homo sapiens	0-4
20415433-6	2010	We used semisynthesis to substitute aspartate 66 in the selectivity filter region of the NaK channel with the unnatural amino acids homoserine and cysteine sulfonic acid.	Aspartic Acid	36-45	TANK binding kinase 1	Homo sapiens	89-92
20385109-5	2010	A very recent report has identified Nat8l as the gene encoding Asp-NAT and confirmed that the only child diagnosed with a lack of NAA on brain magnetic resonance spectrograms has a 19-bp deletion in this gene.	Aspartic Acid	63-66	N-acetyltransferase 8 like	Homo sapiens	36-41
20385109-7	2010	In studies done concurrently in our laboratory we have demonstrated via cloning, expression, specificity for acetylation of aspartate, responsiveness to methamphetamine treatment, molecular modeling and comparative immunolocalization that NAT8L is the NAA biosynthetic enzyme Asp-NAT.	Aspartic Acid	124-133	N-acetyltransferase 8 like	Homo sapiens	239-244
20642010-0	2004	Cy5-labeled aza-peptidyl Pro-Asn epoxide Legumain or asparaginyl endopeptidase is a lysosomal cysteine protease that cleaves protein substrates on the C-terminal side of asparagine and, occasionally, aspartic acid residues (1-3).	Aspartic Acid	200-213	legumain	Homo sapiens	53-78
20642015-17	2004	Asp-Glu-Val-Asp (DEVD) is the peptide sequence optimal for caspase-3 and -7, while the Val-Glu-His-Asp (VEHD) sequence is preferred by caspase-6 (5).	Aspartic Acid	0-3	caspase 3	Homo sapiens	59-75
20642015-17	2004	Asp-Glu-Val-Asp (DEVD) is the peptide sequence optimal for caspase-3 and -7, while the Val-Glu-His-Asp (VEHD) sequence is preferred by caspase-6 (5).	Aspartic Acid	0-3	caspase 6	Homo sapiens	135-144
20175985-8	2010	Finally, we show that pyridinyl imidazoles that potently bind to the inactive p38alpha MAPK prevent activation of p38 MAPK in living cells, suggesting that pyridinyl imidazoles other than SB203580 are able to induce the DFG-out conformation that is incompatible with activation (where DFG is a single-letter amino acid code for the aspartate-phenylalanine-glycine sequence at the start of the activation loop).	Aspartic Acid	332-341	mitogen-activated protein kinase 14	Homo sapiens	78-81
20175985-8	2010	Finally, we show that pyridinyl imidazoles that potently bind to the inactive p38alpha MAPK prevent activation of p38 MAPK in living cells, suggesting that pyridinyl imidazoles other than SB203580 are able to induce the DFG-out conformation that is incompatible with activation (where DFG is a single-letter amino acid code for the aspartate-phenylalanine-glycine sequence at the start of the activation loop).	Aspartic Acid	332-341	mitogen-activated protein kinase 14	Homo sapiens	114-117
20346911-6	2010	PMIRRAS spectra also indicate a change of carboxylate orientation in the aspartate and glutamate residues implicated in the association of the AnxA5, which could be linked to the 2D crystallization of protein under the phospholipid monolayer.	Aspartic Acid	73-82	annexin A5	Homo sapiens	143-148
20347923-1	2010	Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad.	Aspartic Acid	179-182	phospholipase A2, group IB, pancreas	Mus musculus	19-37
20347923-1	2010	Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad.	Aspartic Acid	179-182	phospholipase A2, group IB, pancreas	Mus musculus	39-45
20392700-5	2010	In the C-telopeptide region of the alpha1 chain, pepsin cleaved between Asp(1035) and Phe(1036), and actinidain between Gly(1032) and Gly(1033).	Aspartic Acid	72-75	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	35-41
20392700-6	2010	Thus, the actinidain-hydrolyzed alpha1 chain is shorter at the C terminus by three residues, Gly(1033), Phe(1034), and Asp(1035).	Aspartic Acid	119-122	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	32-38
19967419-7	2010	A replacement consisting of gamma-amino butyric acid and aspartic acid, where the amino group from the former was linked to the main chain carboxyl group of the latter, was found to be, at high concentrations, more active than the B-2 peptide.	Aspartic Acid	57-70	immunoglobulin kappa variable 5-2	Homo sapiens	231-234
20060974-4	2010	RESULTS: This study has made the following findings: first, we verified that caspase-1 and caspase-9 shared 100% aspartic acid in the P1 position.	Aspartic Acid	113-126	caspase 1	Homo sapiens	77-86
20060974-4	2010	RESULTS: This study has made the following findings: first, we verified that caspase-1 and caspase-9 shared 100% aspartic acid in the P1 position.	Aspartic Acid	113-126	caspase 9	Homo sapiens	91-100
20347923-1	2010	Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad.	Aspartic Acid	179-182	phospholipase A2, group IB, pancreas	Mus musculus	73-79
20347923-1	2010	Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad.	Aspartic Acid	179-182	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	81-88
20445534-6	2010	In a multivariate analysis, CYP2C9 359Leu remained associated with the non-ASP group (OR = 7.2 (2.6-20.3), P = 0.0002) even though 40% of these patients were under treatment with antiulcer drugs at the time of admission.	Aspartic Acid	75-78	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	28-34
20564550-3	2010	Protein L-isoaspartyl/D-aspartyl O-methyltransferase (PIMT) is a repair enzyme that initiates the conversion of L-isoAsp (or D-Asp) residues to L-Asp residues.	Aspartic Acid	144-149	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	0-52
20564550-3	2010	Protein L-isoaspartyl/D-aspartyl O-methyltransferase (PIMT) is a repair enzyme that initiates the conversion of L-isoAsp (or D-Asp) residues to L-Asp residues.	Aspartic Acid	144-149	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	54-58
20564559-7	2010	These results indicate that the inversion rate to D-form of Asp residues in skin elastin is accelerated by generation of reactive oxygen species (ROS), and that oxidative stress might be closely related to D-Asp formation in aging proteins.	Aspartic Acid	60-63	elastin	Homo sapiens	81-88
20213214-2	2010	Here we have developed a novel strategy to pattern cells using a hyaluronic acid hydrogel material and photocaged RGDS (Arg-Gly-Asp-Ser) peptides.	Aspartic Acid	128-131	ral guanine nucleotide dissociation stimulator	Homo sapiens	114-118
20184932-8	2010	Radiographic and histological examination, Western blotting and RT-PCR showed that P24/PLGA-(PEG-ASP)n scaffold could induce more effective ectopic bone formation in vivo, as compared with PLGA-(PEG-ASP)n or gelatin sponge alone.	Aspartic Acid	97-100	transmembrane p24 trafficking protein 2	Homo sapiens	83-86
19768790-4	2010	The presence of a small molecule that inhibits autophosphorylation of the FGF2 receptor blocked the effects of FGF2 on hMSC viability in PEG hydrogels, both in the presence and absence of the Arg-Gly-Asp-Ser-Pro (RGDSP) ligand.	Aspartic Acid	200-203	fibroblast growth factor 2	Homo sapiens	74-78
20184932-8	2010	Radiographic and histological examination, Western blotting and RT-PCR showed that P24/PLGA-(PEG-ASP)n scaffold could induce more effective ectopic bone formation in vivo, as compared with PLGA-(PEG-ASP)n or gelatin sponge alone.	Aspartic Acid	199-202	transmembrane p24 trafficking protein 2	Homo sapiens	83-86
20200118-4	2010	Recently, three arginine residues within the large intracellular loop of the 5-HT(3A) subunit were substituted by their equivalent residues (glutamine, aspartate, and alanine) of the 5-HT(3B) subunit to produce a 5-HT(3A)(QDA) subunit that forms functional homomeric channels exhibiting a measurable single-channel conductance.	Aspartic Acid	152-161	5-hydroxytryptamine receptor 3B	Homo sapiens	183-190
20193774-6	2010	For TAP1-637, Asp/Gly heterozygosity was significantly more prevalent in CE patients than in controls (20 vs. 4%, odds ratio 6.0), while Gly/Gly homozygosity was less frequent (5 vs. 14%).	Aspartic Acid	14-17	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	4-8
20374902-2	2010	A missense mutation G/A in position 1426, which causes Asp-Asn substitution at position 298 in the MC4R gene has been associated with feed intake, fatness and growth, however published results of its effect are inconsistent.	Aspartic Acid	55-58	melanocortin 4 receptor	Sus scrofa	99-103
20571112-5	2010	In addition, HopF2 Arg-71 and Asp-175 residues that are required for the interaction with MKK5 are also necessary for blocking MAP kinase activation, PAMP-triggered defenses, and virulence function in plants.	Aspartic Acid	30-33	MAP kinase kinase 5	Arabidopsis thaliana	90-94
20308061-5	2010	The stability of the resultant large latent complex is dependent upon covalent dimerization of LAP, which is facilitated by key residues (Phe(198), Asp(199), Val(200), Leu(208), Phe(217), and Leu(219)) at the dimer interface.	Aspartic Acid	148-151	transforming growth factor beta 1	Homo sapiens	95-98
20561401-2	2010	The AsnS mRNA expression level in 8 cell lines (Jurkat, HL-60, U937, NB4, THP-1, Namalwa, Karpas299 and K562) was determined by real-time quantitative PCR (RQ-PCR) based on fluorescence dye Eva Green before and after treatment with L-Asp, and the cell proliferation rates were analyzed by CCK-8 assay.	Aspartic Acid	232-237	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	4-8
20561401-3	2010	The results showed that there was a significant disparity of AsnS expression level in 8 cell lines, and there were significant increases of AsnS expression level in cells co-cultured with L-Asp (p &lt; 0.05).	Aspartic Acid	188-193	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	140-144
20561401-6	2010	It is concluded that the AsnS plays a critical role in regulating cellular biological behavior after depletion of asparagine, the AsnS mRNA expression level in cells reflects the sensitivity of cells to L-Asp.	Aspartic Acid	203-208	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	25-29
20561401-6	2010	It is concluded that the AsnS plays a critical role in regulating cellular biological behavior after depletion of asparagine, the AsnS mRNA expression level in cells reflects the sensitivity of cells to L-Asp.	Aspartic Acid	203-208	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	130-134
20457940-7	2010	Working with recombinant Gsalpha, we report that mutating its SWI-Thr to either Ala, Glu, Gln, or Asp results not only in diminished GTPase activity but also in spontaneous activation of the SWII domain.	Aspartic Acid	98-101	GNAS complex locus	Homo sapiens	25-32
20228838-4	2010	We mapped the residues important for the FRS2beta and ERK interaction to two docking (D) domain-like sequences on FRS2beta and two aspartic acid residues in the common docking (CD) domain of ERK.	Aspartic Acid	131-144	fibroblast growth factor receptor substrate 3	Homo sapiens	41-49
20228838-4	2010	We mapped the residues important for the FRS2beta and ERK interaction to two docking (D) domain-like sequences on FRS2beta and two aspartic acid residues in the common docking (CD) domain of ERK.	Aspartic Acid	131-144	EPH receptor B2	Homo sapiens	54-57
20228838-4	2010	We mapped the residues important for the FRS2beta and ERK interaction to two docking (D) domain-like sequences on FRS2beta and two aspartic acid residues in the common docking (CD) domain of ERK.	Aspartic Acid	131-144	EPH receptor B2	Homo sapiens	191-194
20236938-5	2010	The acidic P3 residue of PAR1, Asp(39), does not hinder binding to the active site and actually makes favorable interactions with Gly(219) of thrombin.	Aspartic Acid	31-34	coagulation factor II thrombin receptor	Homo sapiens	25-29
20201581-7	2010	When two carboxyl moieties on Asp and Glu residues coordinated to CP2-Zn(2+), the hydrophobic interaction took place by the aggregation of the hydrophobic amino acid residues with phenyl group on CP2-Zn(2+).	Aspartic Acid	30-33	ceruloplasmin	Homo sapiens	66-69
20201581-7	2010	When two carboxyl moieties on Asp and Glu residues coordinated to CP2-Zn(2+), the hydrophobic interaction took place by the aggregation of the hydrophobic amino acid residues with phenyl group on CP2-Zn(2+).	Aspartic Acid	30-33	ceruloplasmin	Homo sapiens	196-199
20231282-3	2010	The central residues that are important for Ca(2+) and K(+) liganding and transport have been identified in NCKX2, and they comprise three central acidic residues, Glu(188) in alpha(1) and Asp(548) and Asp(575) in alpha(2), as well as Ser/Thr residues one-helical turn away from these residues.	Aspartic Acid	189-192	solute carrier family 24 member 2	Homo sapiens	108-113
20231282-3	2010	The central residues that are important for Ca(2+) and K(+) liganding and transport have been identified in NCKX2, and they comprise three central acidic residues, Glu(188) in alpha(1) and Asp(548) and Asp(575) in alpha(2), as well as Ser/Thr residues one-helical turn away from these residues.	Aspartic Acid	202-205	solute carrier family 24 member 2	Homo sapiens	108-113
20642000-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
20642000-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
20236938-5	2010	The acidic P3 residue of PAR1, Asp(39), does not hinder binding to the active site and actually makes favorable interactions with Gly(219) of thrombin.	Aspartic Acid	31-34	coagulation factor II, thrombin	Homo sapiens	142-150
20307547-6	2010	In the complex, dimethylated Lys382 is restrained by a set of hydrophobic and cation-pi interactions in a cage formed by four aromatic residues and an aspartate of 53BP1.	Aspartic Acid	151-160	tumor protein p53 binding protein 1	Homo sapiens	164-169
20040518-3	2010	BRAP2 inhibition of nuclear accumulation was dependent on phosphorylation sites flanking the respective NLSs, where substitution of the cyclin-dependent kinase site T124 of T-ag with Ala or Asp prevented or enhanced BRAP2 inhibition of nuclear import, respectively.	Aspartic Acid	190-193	BRCA1 associated protein	Homo sapiens	0-5
20015484-1	2010	BACKGROUND: SLC25A12, a susceptibility gene for autism spectrum disorders that is mutated in a neurodevelopmental syndrome, encodes a mitochondrial aspartate-glutamate carrier (aspartate-glutamate carrier isoform 1 [AGC1]).	Aspartic Acid	148-157	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	12-20
20015484-1	2010	BACKGROUND: SLC25A12, a susceptibility gene for autism spectrum disorders that is mutated in a neurodevelopmental syndrome, encodes a mitochondrial aspartate-glutamate carrier (aspartate-glutamate carrier isoform 1 [AGC1]).	Aspartic Acid	177-186	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	12-20
20040518-3	2010	BRAP2 inhibition of nuclear accumulation was dependent on phosphorylation sites flanking the respective NLSs, where substitution of the cyclin-dependent kinase site T124 of T-ag with Ala or Asp prevented or enhanced BRAP2 inhibition of nuclear import, respectively.	Aspartic Acid	190-193	BRCA1 associated protein	Homo sapiens	216-221
20160067-2	2010	Since acidic amino acids have well-documented affinities to both HAp and basic proteins, HAp modified by aspartic acid (Asp, acidic amino acid) might be one of the candidate substrates for a basic protein carrier.	Aspartic Acid	105-118	retinoic acid receptor beta	Homo sapiens	65-68
20160067-2	2010	Since acidic amino acids have well-documented affinities to both HAp and basic proteins, HAp modified by aspartic acid (Asp, acidic amino acid) might be one of the candidate substrates for a basic protein carrier.	Aspartic Acid	105-118	retinoic acid receptor beta	Homo sapiens	89-92
20332332-3	2010	We generated a construct encoding DSPP, in which Asp(452), a cleavage site residue, was replaced by Ala(452).	Aspartic Acid	49-52	dentin sialophosphoprotein	Mus musculus	34-38
20332332-5	2010	These studies showed that the substitution of Asp(452) by Ala(452) completely blocks the cleavage of mouse DSPP in the transfected cells, indicating that the NH(2)-terminal peptide bond of Asp(452) is essential for the initiation of DSPP proteolytic processing.	Aspartic Acid	46-49	dentin sialophosphoprotein	Mus musculus	107-111
20160067-2	2010	Since acidic amino acids have well-documented affinities to both HAp and basic proteins, HAp modified by aspartic acid (Asp, acidic amino acid) might be one of the candidate substrates for a basic protein carrier.	Aspartic Acid	120-123	retinoic acid receptor beta	Homo sapiens	65-68
20332332-5	2010	These studies showed that the substitution of Asp(452) by Ala(452) completely blocks the cleavage of mouse DSPP in the transfected cells, indicating that the NH(2)-terminal peptide bond of Asp(452) is essential for the initiation of DSPP proteolytic processing.	Aspartic Acid	46-49	dentin sialophosphoprotein	Mus musculus	233-237
20160067-2	2010	Since acidic amino acids have well-documented affinities to both HAp and basic proteins, HAp modified by aspartic acid (Asp, acidic amino acid) might be one of the candidate substrates for a basic protein carrier.	Aspartic Acid	120-123	retinoic acid receptor beta	Homo sapiens	89-92
20160067-3	2010	Here, we synthesized HAp in the presence of various concentrations of Asp and observed that HAp crystallinity and other physico-chemical properties were effectively modulated.	Aspartic Acid	70-73	retinoic acid receptor beta	Homo sapiens	21-24
20385745-5	2010	To address this issue, we mutated Shaker residues I287 and F324, which correspond to the binding site residues in eag, to aspartate and recorded ionic and gating currents in the presence and absence of extracellular Mg(2+).	Aspartic Acid	122-131	potassium voltage-gated channel subfamily H member 1	Homo sapiens	114-117
20160067-3	2010	Here, we synthesized HAp in the presence of various concentrations of Asp and observed that HAp crystallinity and other physico-chemical properties were effectively modulated.	Aspartic Acid	70-73	retinoic acid receptor beta	Homo sapiens	92-95
20160067-4	2010	Detailed studies indicated that Asp was not incorporated in the HAp crystal lattice, but rather was trapped in HAp crystals.	Aspartic Acid	32-35	retinoic acid receptor beta	Homo sapiens	111-114
20160067-5	2010	Protein adsorption studies indicated that the HAp particles modified by Asp had a selective loading capacity for basic protein.	Aspartic Acid	72-75	retinoic acid receptor beta	Homo sapiens	46-49
20160067-6	2010	Therefore, HAp particles containing Asp might have potential in drug delivery applications, especially as the carrier of basic proteins including bFGF and BMP.	Aspartic Acid	36-39	retinoic acid receptor beta	Homo sapiens	11-14
20235117-10	2010	Results demonstrated that the peptide 3C (H-Tyr-Ile-Glu-Gly-Leu-Gln-Ala-Leu-Leu-Arg-Asp-Gln-NH(2)) not only showed high affinity for Id1 but also exhibited antiproliferative effects in HT-29 and MCF-7 cancer cells; the IC(50) value of 3C was determined as 25 microM in both cells.	Aspartic Acid	84-87	inhibitor of DNA binding 1, HLH protein	Homo sapiens	133-136
20351256-4	2010	However, efforts to inactivate ErbB3 therapeutically in parallel with other ErbB receptors are challenging because its intracellular kinase domain is thought to be an inactive pseudokinase that lacks several key conserved (and catalytically important) residues-including the catalytic base aspartate.	Aspartic Acid	290-299	erb-b2 receptor tyrosine kinase 3	Homo sapiens	31-36
20202874-7	2010	This change results in a substitution of aspartic acid to asparagine in a highly conserved domain of the ND3 subunit.	Aspartic Acid	41-54	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	105-108
20385800-4	2010	Aspartate-97, located at the alpha1 GlyR interface, is a conserved residue in the cys-loop receptor superfamily.	Aspartic Acid	0-9	glycine receptor alpha 1	Homo sapiens	29-40
20200249-9	2010	TRF2 mutants with a serine-to-aspartic acid phosphomimetic substitution mutation were reduced in their ability to recruit the origin recognition complex (ORC) and stimulate OriP replication.	Aspartic Acid	30-43	telomeric repeat binding factor 2	Homo sapiens	0-4
20608076-2	2010	Nine samples contained asparaginic acid at position 222 of HA1 (D).	Aspartic Acid	23-39	Rho GTPase activating protein 45	Homo sapiens	59-62
20351256-4	2010	However, efforts to inactivate ErbB3 therapeutically in parallel with other ErbB receptors are challenging because its intracellular kinase domain is thought to be an inactive pseudokinase that lacks several key conserved (and catalytically important) residues-including the catalytic base aspartate.	Aspartic Acid	290-299	epidermal growth factor receptor	Homo sapiens	31-35
20190277-7	2010	Furthermore, we have established that two amino acids in this motif, Asp(861) and Gln(866), are essential for the interaction between Claspin and DDK.	Aspartic Acid	69-72	claspin S homeolog	Xenopus laevis	134-141
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Aspartic Acid	98-101	glycolipid transfer protein	Homo sapiens	37-41
20383279-9	2010	We found a conserved nitration site of ERK1/2 to be located in their kinase domain on Tyr(156/139), close to their active site Asp(166/149), in agreement with a permissive function of nitration for their activation.	Aspartic Acid	127-130	mitogen-activated protein kinase 3	Homo sapiens	39-45
20336258-2	2010	In the spectral region of 32,800 cm(-1) to 35,500 cm(-1) we observe five isomers of guanine-aspartic acid clusters and assign their structures based on IR-UV hole-burning spectra and wave function theory calculations at the MP2/cc-pVDZ and MP2/cc-pVTZ levels.	Aspartic Acid	92-105	tryptase pseudogene 1	Homo sapiens	224-227
20336258-2	2010	In the spectral region of 32,800 cm(-1) to 35,500 cm(-1) we observe five isomers of guanine-aspartic acid clusters and assign their structures based on IR-UV hole-burning spectra and wave function theory calculations at the MP2/cc-pVDZ and MP2/cc-pVTZ levels.	Aspartic Acid	92-105	tryptase pseudogene 1	Homo sapiens	240-243
20159985-2	2010	We found that B cells derived from cavity-based B cell lymphoma with lytic KSHV infection display activation of caspase-8 and cleavage of ORF57 in the cytoplasm by caspase-7 at the aspartate residue at position 33 from the N terminus.	Aspartic Acid	181-190	ORF57	Human gammaherpesvirus 8	138-143
20159985-2	2010	We found that B cells derived from cavity-based B cell lymphoma with lytic KSHV infection display activation of caspase-8 and cleavage of ORF57 in the cytoplasm by caspase-7 at the aspartate residue at position 33 from the N terminus.	Aspartic Acid	181-190	caspase 7	Homo sapiens	164-173
19945438-1	2010	A novel human thiopurine S-methyltransferase (TPMT) variant allele, (319 T&gt;G, 107Tyr&gt;Asp, *27), was identified in a Thai renal transplantation recipient with reduced erythrocyte TPMT activity.	Aspartic Acid	91-94	thiopurine S-methyltransferase	Homo sapiens	14-44
19945438-1	2010	A novel human thiopurine S-methyltransferase (TPMT) variant allele, (319 T&gt;G, 107Tyr&gt;Asp, *27), was identified in a Thai renal transplantation recipient with reduced erythrocyte TPMT activity.	Aspartic Acid	91-94	thiopurine S-methyltransferase	Homo sapiens	46-50
19945438-1	2010	A novel human thiopurine S-methyltransferase (TPMT) variant allele, (319 T&gt;G, 107Tyr&gt;Asp, *27), was identified in a Thai renal transplantation recipient with reduced erythrocyte TPMT activity.	Aspartic Acid	91-94	thiopurine S-methyltransferase	Homo sapiens	184-188
20133434-7	2010	BCATm KO mice exhibited 43-79% declines in the muscle concentration of alanine, glutamine, aspartate, and glutamate at rest and during exercise.	Aspartic Acid	91-100	branched chain aminotransferase 2, mitochondrial	Mus musculus	0-5
20160131-8	2010	Using this vector, we explored P450c17 phosphorylation by mutagenesis of Ser and/or Thr residues to Asp or Glu to mimic the approximate size and charge of phospho-Ser or phospho-Thr.	Aspartic Acid	100-103	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	31-38
19933177-17	2010	Cochlin expression was effective in decreasing OF and increasing ASP in MOCAS, suggesting possible involvement of cochlin in IOP elevation in vivo.	Aspartic Acid	65-68	cochlin	Homo sapiens	0-7
20035740-7	2010	Further experiments revealed that Asp(330), Ser(331) and Glu(332) are not only involved in receptor recycling, but are also required for promotion of CRTH2 internalization by GRK2 and GRK5.	Aspartic Acid	34-37	prostaglandin D2 receptor 2	Homo sapiens	150-155
19775205-1	2010	The SIBLING family (small integrin-binding ligand N-linked glycoproteins) of mineral-regulating proteins, which includes matrix extracellular phosphoglycoprotein (MEPE) and osteopontin (OPN), contains an acidic serine- and aspartate-rich motif (ASARM).	Aspartic Acid	223-232	matrix extracellular phosphoglycoprotein	Homo sapiens	163-167
19908284-1	2010	The mitochondrial aspartate-glutamate carriers (AGC) aralar (SLC25A12) and citrin (SLC25A13) are components of the malate aspartate shuttle (MAS), a major intracellular pathway to transfer reducing equivalents from NADH to the mitochondrial matrix.	Aspartic Acid	18-27	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	61-69
19908284-1	2010	The mitochondrial aspartate-glutamate carriers (AGC) aralar (SLC25A12) and citrin (SLC25A13) are components of the malate aspartate shuttle (MAS), a major intracellular pathway to transfer reducing equivalents from NADH to the mitochondrial matrix.	Aspartic Acid	18-27	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	83-91
20035740-7	2010	Further experiments revealed that Asp(330), Ser(331) and Glu(332) are not only involved in receptor recycling, but are also required for promotion of CRTH2 internalization by GRK2 and GRK5.	Aspartic Acid	34-37	G protein-coupled receptor kinase 2	Homo sapiens	175-179
20035740-7	2010	Further experiments revealed that Asp(330), Ser(331) and Glu(332) are not only involved in receptor recycling, but are also required for promotion of CRTH2 internalization by GRK2 and GRK5.	Aspartic Acid	34-37	G protein-coupled receptor kinase 5	Homo sapiens	184-188
20237569-7	2010	Finally, the comparison of Ca(2+)-binding CUB domains and the low-density lipoprotein (LDL) receptor-type A modules suggests that the electrostatic pairing of a basic ligand arginine/lysine residue with Ca(2+)-coordinating acidic aspartates/glutamates is a common theme of Ca(2+)-dependent ligand-receptor interactions.	Aspartic Acid	230-240	low density lipoprotein receptor	Homo sapiens	62-100
20171188-7	2010	The apoptosis-inducing activity of Del1 could be mapped to the third EGF motif, which fitted the consensus sequence CX(D/N)XXXX(F/Y)XCXC, wherein the aspartic acid residue (D) could be beta-hydroxylated.	Aspartic Acid	150-163	EGF-like repeats and discoidin I-like domains 3	Mus musculus	35-39
20181484-4	2010	The comparative effects of aminoureas on wild-type BuChE and several BuChE mutants indicate a binding process involving salt linkage with the aspartate of the cholinesterase peripheral anionic site.	Aspartic Acid	142-151	butyrylcholinesterase	Homo sapiens	159-173
20184307-2	2010	Radiolabeled RGD (Arg-Gly-Asp) peptides that specifically target integrin alphavbeta3 have great potential for tumor early detection and noninvasively monitoring the status of tumor angiogenesis.	Aspartic Acid	26-29	integrin subunit alpha V	Homo sapiens	65-85
20375004-2	2010	We report that stiff skin syndrome (SSS), an autosomal dominant congenital form of scleroderma, is caused by mutations in the sole Arg-Gly-Asp sequence-encoding domain of fibrillin-1 that mediates integrin binding.	Aspartic Acid	139-142	fibrillin 1	Homo sapiens	171-182
20071328-3	2010	Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties.	Aspartic Acid	101-104	coagulation factor II, thrombin	Homo sapiens	24-32
20071328-3	2010	Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties.	Aspartic Acid	101-104	secreted phosphoprotein 1	Homo sapiens	140-143
20025926-2	2010	DHDPS catalyses the first committed step in (S)-lysine biosynthesis: the Schiff-base mediated aldol condensation of pyruvate with (S)-aspartate semi-aldehyde.	Aspartic Acid	130-143	dihydrodipicolinate synthase	Escherichia coli	0-5
20042600-2	2010	We had identified four residues (Tyr-63, Ile-66, Asp-69, and Gln-70), presumably contained in an alpha-helix, as a potential binding site for LPL.	Aspartic Acid	49-52	lipoprotein lipase	Homo sapiens	142-145
20048145-3	2010	Substitution of the activation loop phosphorylation site (Ser-221) in the NTK with the negatively charged Asp residue abrogated the association between RSK1 and PKARIalpha.	Aspartic Acid	106-109	ribosomal protein S6 kinase A1	Homo sapiens	152-156
19875662-10	2010	Aspartic acid isomerization to isoaspartic acid occurs at the major truncation sites of filensin (D431) and of CP49 (D37).	Aspartic Acid	0-13	beaded filament structural protein 1	Bos taurus	88-96
20015864-6	2010	In vitro caspase cleavage assay and mutagenesis experiment reveal that ANP32B is a direct substrate of caspase-3 and it is primarily cleaved at the sequence of Ala-Glu-Val-Asp, after Asp-163.	Aspartic Acid	172-175	acidic nuclear phosphoprotein 32 family member B	Homo sapiens	71-77
20015864-6	2010	In vitro caspase cleavage assay and mutagenesis experiment reveal that ANP32B is a direct substrate of caspase-3 and it is primarily cleaved at the sequence of Ala-Glu-Val-Asp, after Asp-163.	Aspartic Acid	183-186	acidic nuclear phosphoprotein 32 family member B	Homo sapiens	71-77
20230086-7	2010	A gene x experience interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele maintained greater positive affect despite elevations in daily pain than those homozygous for the asn allele.	Aspartic Acid	102-105	opioid receptor mu 1	Homo sapiens	36-41
20117248-1	2010	To explore the hypothesis that angiotensin II may play a role in the susceptibility to cerebral malaria (CM), we performed a genetic association study of malaria patients in Orissa, India analyzing three SNPs (ACE2 C-->T, iNOS C-->T, eNOS Glu-->Asp) and two I/D polymorphisms (ACE I/D and IL-4 B1/B2).	Aspartic Acid	245-248	angiotensinogen	Homo sapiens	31-45
20117248-3	2010	Combined genotype analysis of eNOS Glu-->Asp substitution responsible for increased NO production in Plasmodium falciparum infected individuals and ACE I/D polymorphism also showed stronger association of (Glu-Asp+Asp-Asp/ID+DD) genotypes with mild malaria (P<0.0001).	Aspartic Acid	210-213	angiotensin I converting enzyme	Homo sapiens	148-151
20117248-3	2010	Combined genotype analysis of eNOS Glu-->Asp substitution responsible for increased NO production in Plasmodium falciparum infected individuals and ACE I/D polymorphism also showed stronger association of (Glu-Asp+Asp-Asp/ID+DD) genotypes with mild malaria (P<0.0001).	Aspartic Acid	210-213	angiotensin I converting enzyme	Homo sapiens	148-151
20117248-3	2010	Combined genotype analysis of eNOS Glu-->Asp substitution responsible for increased NO production in Plasmodium falciparum infected individuals and ACE I/D polymorphism also showed stronger association of (Glu-Asp+Asp-Asp/ID+DD) genotypes with mild malaria (P<0.0001).	Aspartic Acid	210-213	angiotensin I converting enzyme	Homo sapiens	148-151
19850839-5	2010	Synthetic PEDF peptides 34-mer (Asp(44)-Asn(77)) and 44-mer (Val(78)-Thr(121)) were used.	Aspartic Acid	32-35	serpin family F member 1	Homo sapiens	10-14
19875662-10	2010	Aspartic acid isomerization to isoaspartic acid occurs at the major truncation sites of filensin (D431) and of CP49 (D37).	Aspartic Acid	0-13	beaded filament structural protein 2	Bos taurus	111-115
19899168-6	2010	The transmembrane (TM) 1 arginine-TM 10 aspartate strut formed less readily in DAT compared with LeuT, with or without substrate present.	Aspartic Acid	40-49	solute carrier family 6 member 3	Homo sapiens	79-82
19887537-7	2010	RESULTS: In the whole population, homozygous IRS2(Asp/Asp) participants were more represented among LL versus C participants (16.7% vs 12.0%; p = .04).	Aspartic Acid	50-53	insulin receptor substrate 2	Homo sapiens	45-49
19887537-7	2010	RESULTS: In the whole population, homozygous IRS2(Asp/Asp) participants were more represented among LL versus C participants (16.7% vs 12.0%; p = .04).	Aspartic Acid	54-57	insulin receptor substrate 2	Homo sapiens	45-49
20025971-0	2010	VEGF up-regulation by G93A superoxide dismutase and the role of malate-aspartate shuttle inhibition.	Aspartic Acid	71-80	vascular endothelial growth factor A	Mus musculus	0-4
20025971-1	2010	A gain of interaction of the amyotrophic lateral sclerosis (ALS)-linked G93A-superoxide dismutase-1 (G93A-hSOD1) with cytosolic malate dehydrogenase (cytMDH), a key enzyme in the malate-aspartate shuttle, diverts neurons towards anaerobic metabolism.	Aspartic Acid	186-195	superoxide dismutase 1	Homo sapiens	106-111
20025971-1	2010	A gain of interaction of the amyotrophic lateral sclerosis (ALS)-linked G93A-superoxide dismutase-1 (G93A-hSOD1) with cytosolic malate dehydrogenase (cytMDH), a key enzyme in the malate-aspartate shuttle, diverts neurons towards anaerobic metabolism.	Aspartic Acid	186-195	malate dehydrogenase 1, NAD (soluble)	Mus musculus	118-148
20025971-1	2010	A gain of interaction of the amyotrophic lateral sclerosis (ALS)-linked G93A-superoxide dismutase-1 (G93A-hSOD1) with cytosolic malate dehydrogenase (cytMDH), a key enzyme in the malate-aspartate shuttle, diverts neurons towards anaerobic metabolism.	Aspartic Acid	186-195	malate dehydrogenase 1, NAD (soluble)	Mus musculus	150-156
20025971-5	2010	Amino-oxyacetate that inhibits the malate-aspartate shuttle caused a similar increase in VEGF mRNA and impaired response to H(2)O(2) in WT-hSOD1 expressing cells.	Aspartic Acid	42-51	vascular endothelial growth factor A	Mus musculus	89-93
20025971-5	2010	Amino-oxyacetate that inhibits the malate-aspartate shuttle caused a similar increase in VEGF mRNA and impaired response to H(2)O(2) in WT-hSOD1 expressing cells.	Aspartic Acid	42-51	superoxide dismutase 1	Homo sapiens	139-144
20025971-7	2010	These results demonstrate that the ALS-linked G93A hSOD1 mutation impairs VEGF regulation compatible with the inhibition of neuronal malate-aspartate shuttle.	Aspartic Acid	140-149	superoxide dismutase 1	Homo sapiens	51-56
20025971-7	2010	These results demonstrate that the ALS-linked G93A hSOD1 mutation impairs VEGF regulation compatible with the inhibition of neuronal malate-aspartate shuttle.	Aspartic Acid	140-149	vascular endothelial growth factor A	Mus musculus	74-78
20050977-3	2010	The present studies employed live cell imaging techniques and the fluorescent, high affinity DAT substrate, 4-(4-(dimethylamino)-styryl)-N-methylpyridinium (ASP(+)), to address this issue.	Aspartic Acid	157-160	solute carrier family 6 member 3	Homo sapiens	93-96
20050977-4	2010	AEA addition to EM4 cells expressing yellow fluorescent protein-tagged human DAT (hDAT) produced a concentration-dependent inhibition of ASP(+) accumulation (IC(50): 3.2 +/- 0.8 microM).	Aspartic Acid	137-143	solute carrier family 6 member 3	Homo sapiens	77-80
20050977-4	2010	AEA addition to EM4 cells expressing yellow fluorescent protein-tagged human DAT (hDAT) produced a concentration-dependent inhibition of ASP(+) accumulation (IC(50): 3.2 +/- 0.8 microM).	Aspartic Acid	137-143	solute carrier family 6 member 3	Homo sapiens	82-86
20097169-2	2010	To study the enzymatic function of BACE, we mutated either of the two aspartic acid residues in the active site of BACE.	Aspartic Acid	70-83	beta-secretase 1	Homo sapiens	35-39
20097169-2	2010	To study the enzymatic function of BACE, we mutated either of the two aspartic acid residues in the active site of BACE.	Aspartic Acid	70-83	beta-secretase 1	Homo sapiens	115-119
20097169-4	2010	In contrast, substituting both active site aspartic acid residues produced a functionally inactive, endoplasmic reticulum-retained and partially glycosylated BACE.	Aspartic Acid	43-56	beta-secretase 1	Homo sapiens	158-162
19861168-4	2010	Analysis of the purine binding domains showed two conserved acidic amino acids; glutamate residues in the xanthine phosphoribosyltransferase (E198 and E215) and aspartate residues in the hypoxanthine-guanine phosphoribosyltransferase (D168 and D185).	Aspartic Acid	161-170	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	187-233
20047332-7	2010	Biophysical measurements using fluorescence polarization and two-dimensional NMR implicate the intermolecular charge pairing of aspartic acid 777 (VE-Cad) and arginine 609 (par3-PDZ3) as a crucial modulator of complex formation.	Aspartic Acid	128-141	cadherin 5	Homo sapiens	147-153
20077461-3	2010	The models were built by using projected pharmacophoric features that represent the main agonist interaction sites in the receptor (the Ser residues in TM5 and the Asp in TM3), a directional aromatic feature in the ligand, a feature with large positional tolerance representing the positively charged nitrogen in the ligand, and sets of excluded volumes reflecting the shapes of the receptors.	Aspartic Acid	164-167	tropomyosin 3	Homo sapiens	171-174
20144272-1	2010	OBJECTIVE: To investigate the role of a functional polymorphism consisting of an aspartic acid (D) repeat located in the asporin gene (ASPN) gene in the susceptibility to and clinical outcome of ankylosing spondylitis (AS).	Aspartic Acid	81-94	asporin	Homo sapiens	121-128
20144272-1	2010	OBJECTIVE: To investigate the role of a functional polymorphism consisting of an aspartic acid (D) repeat located in the asporin gene (ASPN) gene in the susceptibility to and clinical outcome of ankylosing spondylitis (AS).	Aspartic Acid	81-94	asporin	Homo sapiens	135-139
19891998-5	2010	The frequency of substitution from Glu (E) to Asp (D) at position 7 (FV9-7D) in the Pol 154-162 (FV9) epitope was significantly higher in HLA-B*5401(+) HIV-infected individuals than in HLA-B*5401(-) individuals, whereas substitutions that were significantly higher in HLA-B*5401(+) individuals than in HLA-B*5401(-) individuals were not found in the other four epitopes.	Aspartic Acid	46-49	major histocompatibility complex, class I, B	Homo sapiens	138-143
19891998-5	2010	The frequency of substitution from Glu (E) to Asp (D) at position 7 (FV9-7D) in the Pol 154-162 (FV9) epitope was significantly higher in HLA-B*5401(+) HIV-infected individuals than in HLA-B*5401(-) individuals, whereas substitutions that were significantly higher in HLA-B*5401(+) individuals than in HLA-B*5401(-) individuals were not found in the other four epitopes.	Aspartic Acid	46-49	major histocompatibility complex, class I, B	Homo sapiens	185-190
19891998-5	2010	The frequency of substitution from Glu (E) to Asp (D) at position 7 (FV9-7D) in the Pol 154-162 (FV9) epitope was significantly higher in HLA-B*5401(+) HIV-infected individuals than in HLA-B*5401(-) individuals, whereas substitutions that were significantly higher in HLA-B*5401(+) individuals than in HLA-B*5401(-) individuals were not found in the other four epitopes.	Aspartic Acid	46-49	major histocompatibility complex, class I, B	Homo sapiens	185-190
19891998-5	2010	The frequency of substitution from Glu (E) to Asp (D) at position 7 (FV9-7D) in the Pol 154-162 (FV9) epitope was significantly higher in HLA-B*5401(+) HIV-infected individuals than in HLA-B*5401(-) individuals, whereas substitutions that were significantly higher in HLA-B*5401(+) individuals than in HLA-B*5401(-) individuals were not found in the other four epitopes.	Aspartic Acid	46-49	major histocompatibility complex, class I, B	Homo sapiens	185-190
20043700-3	2010	NMR data and the crystal structure revealed that this hit makes H-bond interactions with the two catalytic aspartates, occupies the nonprime side region of the active site of BACE-1, and extends toward the S3 subpocket (S3sp).	Aspartic Acid	107-117	beta-secretase 1	Homo sapiens	175-181
19939918-8	2010	We further showed that the Q (Gln-rich), SP (Ser-Pro-rich), and WDR (Trp-Asp repeat) domains of TLE2 and the Pro-rich domain of RTA were essential for this interaction.	Aspartic Acid	73-76	TLE family member 2, transcriptional corepressor	Homo sapiens	96-100
19819898-8	2010	The dual characteristics of chymosin are due to the occurrence of polar/charged residues in the S1" subsite, such as Glu/Asp(289), Gln(298) and Lys/Gln(299), which are different from the S1" subsite of pepsin A.	Aspartic Acid	121-124	chymosin	Bos taurus	28-36
19819898-9	2010	Molecular models suggest that Glu in position 289 of bovine chymosin and Asp in position 289 of monkey chymosin are responsible for the difference in P1" specificities between the chymosins.	Aspartic Acid	73-76	chymosin	Bos taurus	103-111
19897476-10	2010	Threonine-resistant HSD offers a useful biotechnology tool for manipulating the aspartate amino acid pathway to increase threonine and methionine production in plants for improved nutritional content.	Aspartic Acid	80-89	homoserine dehydrogenase	Glycine max	20-23
20015111-4	2010	We find that (i) the intrinsic motif of GGA1 is inactive, (ii) only C-terminal DXXLL motifs constitute active GGA binding sites, (iii) while aspartates and phosphorylated serines one or two positions upstream of the DXXLL motif increase GGA1 binding, phosphoserines further upstream have little or no influence and (iv) phosphorylation of GGA1 does not affect its conformation or binding to Sortilin and SorLA.	Aspartic Acid	141-151	golgi associated, gamma adaptin ear containing, ARF binding protein 1	Homo sapiens	40-44
19940152-7	2010	The key findings of the study are that the metal binding site is composed of a Asp-Gly-His motif in IS3-S4 and a second aspartate residue in IS2.	Aspartic Acid	120-129	IS2	Homo sapiens	141-144
19822234-7	2010	Such recognition was mediated via a "second" arginine-glycine-aspartic acid (RGD) sequence that is present in the V95 subsegment in rat, but not human, FN.	Aspartic Acid	62-75	fibronectin 1	Homo sapiens	152-154
19818814-3	2010	By using the fusion expression with unique acid labile linker Asp-Pro and biochemical purification, the three novel GHRH peptides, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys, Pro-hGHRH(1-44)-Gly-Gly-Cys, and (1)Pro-GHRH(2-44)-Gly-Gly-Cys, were obtained.	Aspartic Acid	62-65	growth hormone releasing hormone	Rattus norvegicus	116-120
19818814-3	2010	By using the fusion expression with unique acid labile linker Asp-Pro and biochemical purification, the three novel GHRH peptides, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys, Pro-hGHRH(1-44)-Gly-Gly-Cys, and (1)Pro-GHRH(2-44)-Gly-Gly-Cys, were obtained.	Aspartic Acid	62-65	growth hormone releasing hormone	Rattus norvegicus	140-144
20053918-1	2010	Previous studies suggested that cleavage of the amyloid precursor protein (APP) at aspartate residue 664 by caspases may play a key role in the pathogenesis of Alzheimer"s disease.	Aspartic Acid	83-92	amyloid beta (A4) precursor protein	Mus musculus	48-73
19935792-4	2010	CCBE1 contains collagen repeats and an aspartic acid/asparagine hydroxylation/EGF-like domain, suggesting a function in extracellular matrix remodelling and migration, which was determined using small-interfering RNA (siRNA)-mediated knockdown and over-expression of CCBE1 in cell lines.	Aspartic Acid	39-52	collagen and calcium binding EGF domains 1	Homo sapiens	0-5
19903461-5	2010	In the core-SRF moiety of the wild-type complex a large spectral change associated with the CO-groups from Asp and/or Glu residues shows that their ionization states and the strength of their interactions decrease as compared to those of mutated non-specific complexes.	Aspartic Acid	107-110	serum response factor	Homo sapiens	12-15
19919181-5	2010	Importantly, further analyses using point mutants showed that a single amino acid change at either Asp-484 or Leu-489 essentially completely abolishes the transactivation activity of Ecd.	Aspartic Acid	99-102	ecdysoneless cell cycle regulator	Homo sapiens	183-186
19944077-10	2010	Altogether the known consensus sequence a-a-a-a-G-S-G-a-a/G-a ("a" representing Asp or Glu) for XT-I mediated xylosylation could be approved and additionally extended to apply to XT-II as well.	Aspartic Acid	80-83	xylosyltransferase 1	Homo sapiens	96-100
19944077-10	2010	Altogether the known consensus sequence a-a-a-a-G-S-G-a-a/G-a ("a" representing Asp or Glu) for XT-I mediated xylosylation could be approved and additionally extended to apply to XT-II as well.	Aspartic Acid	80-83	xylosyltransferase 2	Homo sapiens	179-184
21170291-4	2010	MiR-21 can be induced in neurons by prolonged N-methyl-D-aspartic acid receptor stimulation, an excitotoxic process active in HIV and other neurodegenerative diseases.	Aspartic Acid	56-70	microRNA 21	Homo sapiens	0-6
19998030-3	2010	The ability of the intact protein and the acidic, serine- and aspartate-rich MEPE-associated motif (ASARM) peptide to promote or inhibit de novo hydroxyapatite formation and growth of hydroxyapatite seed crystals, in both phosphorylated and dephosphorylated forms, was assessed at room temperature in a dynamic gel diffusion system at 3.5 and 5 days.	Aspartic Acid	62-71	matrix extracellular phosphoglycoprotein	Homo sapiens	77-81
20332619-5	2010	Notably, CFTR mutations not causal for classical cystic fibrosis segregate with unexplained pancreatitis and one of these lies in NBD1 near its ATP-clamp (S573C; close to the Walker B aspartate D572).	Aspartic Acid	184-193	CF transmembrane conductance regulator	Homo sapiens	9-13
21048299-2	2010	Through in vitro reconstitution, we found that sialin, a lysosomal sialic acid exporter, is responsible for the vesicular storage of aspartate in hippocampal neurons and pinealocytes.	Aspartic Acid	133-142	solute carrier family 17 member 5	Homo sapiens	47-53
20697181-7	2010	The novel heterozygous mutation (D190G) identified in the present study showed that the reduction of activity of CASR to extracellular Ca(2+) caused FHH in patients and our study demonstrated the importance of Asp-190 participated in response to Ca(2+) in CASR.	Aspartic Acid	210-213	calcium sensing receptor	Homo sapiens	113-117
20697181-7	2010	The novel heterozygous mutation (D190G) identified in the present study showed that the reduction of activity of CASR to extracellular Ca(2+) caused FHH in patients and our study demonstrated the importance of Asp-190 participated in response to Ca(2+) in CASR.	Aspartic Acid	210-213	calcium sensing receptor	Homo sapiens	256-260
20508833-5	2010	In the in vitro kinase assay, HIPK4 exhibits kinase activity and mutation of the conserved lysine 40 or aspartic acid 136 residue in its catalytic domain inactivates its kinase function.	Aspartic Acid	104-117	homeodomain interacting protein kinase 4	Homo sapiens	30-35
21394217-7	2010	The XPD diplotypes were coded as the combination of two of the following haplotypes: haplotype A=(Lys)751A/(Asp) 312G; B=(Gln)751C/(Asn)312A; C=(Lys)751A/(Asn)312A; and D=(Gln)751C/(Asp)312G.	Aspartic Acid	108-111	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
21394217-7	2010	The XPD diplotypes were coded as the combination of two of the following haplotypes: haplotype A=(Lys)751A/(Asp) 312G; B=(Gln)751C/(Asn)312A; C=(Lys)751A/(Asn)312A; and D=(Gln)751C/(Asp)312G.	Aspartic Acid	182-185	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
19896876-7	2010	Aspartyl-tRNA synthetase (AspRS) belongs to class II aaRSs, is not only important to sustain the mechanism of protein fidelity by specifically recognizing its cognate amino acid; but also equally significant in the aminoacylation of tRNA(Asp).	Aspartic Acid	0-3	aspartyl-tRNA synthetase 1	Homo sapiens	26-31
19693700-6	2010	The PCR-RFLP method was utilized to genotype 600 study subject for the XPG Asp (1104) His gene polymorphism.	Aspartic Acid	75-78	ERCC excision repair 5, endonuclease	Homo sapiens	71-74
20056579-6	2010	Activation of the MKK3/6-p38 signaling pathway marked the effect of NP on TNF-alpha expression, concomitant with enhanced levels of methyltranferase complex [mixed-lineage leukemia (MLL) and tryptophan-aspartic acid repeat domain 5 (WDR5)] in the nucleus and of trimethylated H3K4, acetylated H3, and H4 at the TNFA gene locus.	Aspartic Acid	202-215	mitogen-activated protein kinase kinase 3	Homo sapiens	18-22
19755569-7	2010	The concentrations of lysine, phenylalanine, leucine, and aspartic acid were all significantly lower in concentration in the aap6 mutant plants compared with wild-type plants.	Aspartic Acid	58-71	amino acid permease 6	Arabidopsis thaliana	125-129
19652917-6	2010	Mutation of the two aspartic acids (aa 294 and 297) into two alanines in TDG significantly affected the interaction and subsequent transcriptional activation of several steroid hormone receptors including, estrogen-, androgen- and progesterone- receptors in Huh7 cells.	Aspartic Acid	20-34	thymine DNA glycosylase	Homo sapiens	73-76
18607376-0	2010	Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1.	Aspartic Acid	125-134	solute carrier family 25 member 12	Homo sapiens	153-157
19882657-0	2010	Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.	Aspartic Acid	121-124	integrin subunit alpha V	Homo sapiens	28-51
19508206-4	2010	Herein, we report the further design of the lead peptide 1 by addition of an Arg-Gly-Asp sequence to 1 to enhance binding to Grb2-SH2 and inducing apoptosis in cancer cells.	Aspartic Acid	85-88	growth factor receptor bound protein 2	Homo sapiens	125-129
19882657-0	2010	Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.	Aspartic Acid	121-124	vitronectin	Homo sapiens	52-63
19807691-6	2009	Transfection studies in HEK-293T [human embryonic kidney-293 cells expressing the large T-antigen of SV40 (simian virus 40)] indicated that NAT8L, but not NAT14, catalysed the synthesis of NAA from L-aspartate and acetyl-CoA.	Aspartic Acid	198-209	N-acetyltransferase 8 like	Homo sapiens	140-145
20030824-11	2009	The lizard DSPP had an intact BMP1 site, a remnant RGD motif, as well as a distinctly different Ser/Asp-rich domain compared to mammals.	Aspartic Acid	100-103	dentin sialophosphoprotein	Homo sapiens	11-15
20013953-5	2010	Upon the Edman degradation reaction, it has been confirmed that a model protein, bovine serum albumin (BSA), releases the N-terminal amino acid quantitatively as PTH-Asp.	Aspartic Acid	166-169	albumin	Homo sapiens	88-101
20641584-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3 and alphavbeta5.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
20641584-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3 and alphavbeta5.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
19759059-3	2009	Here, we identify a polymorphism in the mitochondrial genome, G-to-T at position 7778, which results in an aspartic acid-to-tyrosine (D-Y) substitution in the fifth amino acid of the highly conserved N-terminus of ATP synthase 8 (ATP8).	Aspartic Acid	107-121	ATP synthase 8, mitochondrial	Mus musculus	214-228
19759059-3	2009	Here, we identify a polymorphism in the mitochondrial genome, G-to-T at position 7778, which results in an aspartic acid-to-tyrosine (D-Y) substitution in the fifth amino acid of the highly conserved N-terminus of ATP synthase 8 (ATP8).	Aspartic Acid	107-121	ATP synthase 8, mitochondrial	Mus musculus	230-234
19807691-7	2009	The specificity of NAT8L, its Km for aspartate and its sensitivity to detergents are similar to those described for brain Asp-NAT.	Aspartic Acid	37-46	N-acetyltransferase 8 like	Homo sapiens	19-24
19807691-7	2009	The specificity of NAT8L, its Km for aspartate and its sensitivity to detergents are similar to those described for brain Asp-NAT.	Aspartic Acid	37-46	bromodomain containing 2	Homo sapiens	19-22
19740707-4	2009	Indeed, deletion of the aa 28-67 domain (MyD88 Delta 28-67) or mutation of the highly conserved amino acid residue phenylalanine (aa 36) to aspartic acid (MyD88 Delta F36D) significantly promoted c-myc activity and expression.	Aspartic Acid	140-153	MYD88 innate immune signal transduction adaptor	Homo sapiens	155-160
19764902-0	2009	Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.	Aspartic Acid	54-63	aggrecan	Rattus norvegicus	82-86
19764902-0	2009	Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.	Aspartic Acid	54-63	solute carrier family 25 member 12	Rattus norvegicus	87-94
19764902-3	2009	AGC1 or Aralar1 (aspartate-glutamate carrier 1) is a key component of the malate-aspartate shuttle.	Aspartic Acid	17-26	aggrecan	Rattus norvegicus	0-4
19764902-3	2009	AGC1 or Aralar1 (aspartate-glutamate carrier 1) is a key component of the malate-aspartate shuttle.	Aspartic Acid	17-26	solute carrier family 25 member 12	Rattus norvegicus	8-15
19764902-4	2009	Overexpression of AGC1 increases the capacity of the malate-aspartate shuttle, resulting in enhanced metabolism-secretion coupling, both in INS-1E cells and rat islets.	Aspartic Acid	60-69	aggrecan	Rattus norvegicus	18-22
19833728-4	2009	Substitutions were made in the DW-motif (Asp-382 and Trp-383) and its interacting residues (Tyr-145 and Arg-149) in the other subunit of PDK2 homodimer.	Aspartic Acid	41-44	pyruvate dehydrogenase kinase 2	Homo sapiens	137-141
19854048-3	2009	Docking studies suggest these inhibitors may bind within the BACE-1 active site through H-bonding interactions involving the catalytic aspartate residues.	Aspartic Acid	135-144	beta-secretase 1	Homo sapiens	61-67
19764902-10	2009	These results show that down-regulation of the key component of the malate-aspartate shuttle AGC1 reduced glucose-induced oxidative metabolism and insulin secretion in INS-1E cells, whereas similar AGC1 knockdown in rat islets did not affect their secretory response.	Aspartic Acid	75-84	aggrecan	Rattus norvegicus	93-97
19764902-10	2009	These results show that down-regulation of the key component of the malate-aspartate shuttle AGC1 reduced glucose-induced oxidative metabolism and insulin secretion in INS-1E cells, whereas similar AGC1 knockdown in rat islets did not affect their secretory response.	Aspartic Acid	75-84	aggrecan	Rattus norvegicus	198-202
20641262-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
20641262-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
20641458-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
20641458-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
20641743-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Mus musculus	121-132
20641917-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	vitronectin	Homo sapiens	121-132
20641917-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Aspartic Acid	29-32	fibrinogen beta chain	Homo sapiens	134-144
19776005-6	2009	However, the phosphomimetic mutation of all four sites to aspartate (4xD) significantly impairs activation of SRF by myocardin, whereas the phosphodeficient mutation of all four sites to alanine (4xA) has no effect.	Aspartic Acid	58-67	serum response factor	Mus musculus	110-113
19737152-1	2009	BACKGROUND: The association between body-mass-index (BMI), alcohol consumption and their joint effect in increasing the risk of elevated serum alanine (ALT) and aspartate (AST) is unclear in older community-dwelling adults.	Aspartic Acid	161-170	solute carrier family 17 member 5	Homo sapiens	172-175
19540337-7	2009	Frequently found mutations in c-Kit and Flt3 are point mutations of aspartic acid 816 and 835 respectively, in the activation loop of the kinase domains.	Aspartic Acid	68-81	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	30-35
19540337-7	2009	Frequently found mutations in c-Kit and Flt3 are point mutations of aspartic acid 816 and 835 respectively, in the activation loop of the kinase domains.	Aspartic Acid	68-81	fms related receptor tyrosine kinase 3	Homo sapiens	40-44
19740707-4	2009	Indeed, deletion of the aa 28-67 domain (MyD88 Delta 28-67) or mutation of the highly conserved amino acid residue phenylalanine (aa 36) to aspartic acid (MyD88 Delta F36D) significantly promoted c-myc activity and expression.	Aspartic Acid	140-153	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	196-201
19919647-9	2009	We also showed that the phosphorylated MOB1B activates NDR1 T444D and LATS2 T1041D, in which threonine residues phosphorylated by MST kinases are replaced with phosphorylation-mimicking aspartic acid, more efficiently than the unphosphorylated MOB1B does.	Aspartic Acid	186-199	MOB kinase activator 1B	Homo sapiens	39-44
19919647-9	2009	We also showed that the phosphorylated MOB1B activates NDR1 T444D and LATS2 T1041D, in which threonine residues phosphorylated by MST kinases are replaced with phosphorylation-mimicking aspartic acid, more efficiently than the unphosphorylated MOB1B does.	Aspartic Acid	186-199	serine/threonine kinase 38	Homo sapiens	55-59
19919647-9	2009	We also showed that the phosphorylated MOB1B activates NDR1 T444D and LATS2 T1041D, in which threonine residues phosphorylated by MST kinases are replaced with phosphorylation-mimicking aspartic acid, more efficiently than the unphosphorylated MOB1B does.	Aspartic Acid	186-199	large tumor suppressor kinase 2	Homo sapiens	70-75
19917732-12	2009	Moreover, substitution of Asp(933) with various residues produces marked changes in proton sensitivity, intracellular ADP ribose/Ca(2+) sensitivity, and gating profiles of TRPM2.	Aspartic Acid	26-29	transient receptor potential cation channel subfamily M member 2	Homo sapiens	172-177
20306720-4	2009	Between P3 and P15, a significant increment in the levels of excitatory amino acids, Asp and Glu, were observed in mice exposed to PQ, as compared with the control group.	Aspartic Acid	85-88	cyclin dependent kinase inhibitor 2B	Mus musculus	15-18
19798595-7	2009	Fibulin-5 contains an evolutionally conserved arginine-glycine-aspartic acid (RGD) motif in the N-terminal region, which mediates binding to a subset of integrins, including alpha5beta1, alphavbeta3, and alphavbeta5.	Aspartic Acid	63-76	fibulin 5	Mus musculus	0-9
20118605-1	2009	Here we examined the significance of Avt6, a vacuolar exporter of glutamate and aspartate suggested by the in vitro membrane vesicle experiment, in vacuolar compartmentalization of amino acids in Saccharomyces cerevisiae cells.	Aspartic Acid	80-89	aspartate/glutamate transporter	Saccharomyces cerevisiae S288C	37-41
19918057-6	2009	Despite the lack of a DFG motif, ATP binding to haspin is similar to that in classical kinases; however, the ATP gamma-phosphate forms hydrogen bonds with the conserved catalytic loop residues Asp-649 and His-651, and a His651Ala haspin mutant is inactive, suggesting a direct role for the catalytic loop in ATP recognition.	Aspartic Acid	193-196	histone H3 associated protein kinase	Homo sapiens	48-54
19330466-4	2009	We have identified polymorphisms in the NOS 3 gene and one of these polymorphisms, Glu(298--&gt;)Asp, was found to be a major risk factor for carotid artery disease and myocardial infarction.	Aspartic Acid	97-100	nitric oxide synthase 3	Homo sapiens	40-45
19953479-3	2009	RESULTS: The DNA sequence of the three patients contained the same substitution of a single nucleotide on codon 681 GAG to GAT of exon 4, which located in the ligand binding domain of the AR receptor and led to substitution of glutamic acid to aspartic acid in the AR receptor.	Aspartic Acid	244-257	glycine-N-acyltransferase	Homo sapiens	123-126
19906198-1	2009	The C1q binding epicentre on IgG molecules involves residues Asp(270), Lys(322), Pro(329) and Pro(331) in the C(H)2 domain.	Aspartic Acid	61-64	complement C1q A chain	Homo sapiens	4-7
19906198-7	2009	We observed a clear difference between IgG1 and IgG3 localized to residues Asp(270), Leu(334), Leu(335).	Aspartic Acid	75-78	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	48-52
19924250-8	2009	The position of WAT1, which hydrogen bonds to both the catalytic aspartates, is different from when there is no substrate bound in the active site.	Aspartic Acid	65-75	MTOR associated protein, LST8 homolog	Homo sapiens	16-20
19812042-9	2009	Importantly, this structural rearrangement positioned one of the oxygen atoms of Asp(52) within 4.3 A of the gamma-phosphate of ATP bound to Srx.	Aspartic Acid	81-84	sulfiredoxin 1	Homo sapiens	141-144
19801655-6	2009	Moreover, the Ser-to-Asp mutation, mimicking a constitutive phosphorylation state at site 774, causes sensitivity to calcofluor, supporting a functional linkage between Rad53 and cellular morphogenesis.	Aspartic Acid	21-24	serine/threonine/tyrosine protein kinase RAD53	Saccharomyces cerevisiae S288C	169-174
19717558-7	2009	Neutralizing these aspartates in Kv2.1 by mutating them to alanines did not affect the gating properties, but reduced the current density moderately.	Aspartic Acid	19-29	potassium voltage-gated channel subfamily B member 1	Homo sapiens	33-38
19751719-4	2009	Whereas the function of the membrane-tethered Mmp2 in the ASP is non-cell autonomous we find that it may have distinct tissue-specific roles in the ASP and disc.	Aspartic Acid	58-61	Matrix metalloproteinase 2	Drosophila melanogaster	46-50
19751719-4	2009	Whereas the function of the membrane-tethered Mmp2 in the ASP is non-cell autonomous we find that it may have distinct tissue-specific roles in the ASP and disc.	Aspartic Acid	148-151	Matrix metalloproteinase 2	Drosophila melanogaster	46-50
19819766-3	2009	This work shows the identification of an isomerized aspartic acid residue in the CDR2 of the heavy chain of a fully human monoclonal antibody.	Aspartic Acid	52-65	cerebellar degeneration related protein 2	Homo sapiens	81-85
19717558-12	2009	These results indicate that these aspartates (especially the first one) in the A/B box linker of the T1 domain are required for efficient assembly of both homotetrameric Kv2.1 and heterotetrameric Kv2.1/silent Kv6.4 channels.	Aspartic Acid	34-44	potassium voltage-gated channel subfamily B member 1	Homo sapiens	170-175
19717558-12	2009	These results indicate that these aspartates (especially the first one) in the A/B box linker of the T1 domain are required for efficient assembly of both homotetrameric Kv2.1 and heterotetrameric Kv2.1/silent Kv6.4 channels.	Aspartic Acid	34-44	potassium voltage-gated channel subfamily B member 1	Homo sapiens	197-202
19717558-12	2009	These results indicate that these aspartates (especially the first one) in the A/B box linker of the T1 domain are required for efficient assembly of both homotetrameric Kv2.1 and heterotetrameric Kv2.1/silent Kv6.4 channels.	Aspartic Acid	34-44	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	210-215
19908197-5	2009	Proteolytic processing of DMP1 by MMP-2 produced two major peptides, one that contains the C-terminal region of the protein known to carry both the ASARM (aspartic acid and serine rich domain) domain involved in biomineralization and the DNA binding site of DMP1.	Aspartic Acid	155-168	dentin matrix acidic phosphoprotein 1	Rattus norvegicus	26-30
19747169-5	2009	Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin.	Aspartic Acid	252-255	fibronectin 1a	Danio rerio	50-63
19747169-5	2009	Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin.	Aspartic Acid	252-255	fibronectin 1a	Danio rerio	50-61
19908197-5	2009	Proteolytic processing of DMP1 by MMP-2 produced two major peptides, one that contains the C-terminal region of the protein known to carry both the ASARM (aspartic acid and serine rich domain) domain involved in biomineralization and the DNA binding site of DMP1.	Aspartic Acid	155-168	matrix metallopeptidase 2	Rattus norvegicus	34-39
19841277-3	2009	Here, we synthesized Abeta variants site-specifically modified with the cholesterol aldehyde at Asp-1, Lys-16, or Lys-28, rather than studying mixtures.	Aspartic Acid	96-99	amyloid beta precursor protein	Rattus norvegicus	21-26
19841277-5	2009	In contrast, the modification site differentially influences the aggregation kinetics; Lys-16-modified Abeta formed amorphous aggregates fastest and at the lowest concentration (within 2 h at a concentration of 20 nM), followed by the Lys-28 and Asp-1 conjugates.	Aspartic Acid	246-249	amyloid beta precursor protein	Rattus norvegicus	103-108
19675305-7	2009	Mutation of a putatively phosphorylated threonine (T504) to aspartic acid within a PKC consensus recognition sequence unique to Kv4.3-L eliminated the PMA response.	Aspartic Acid	60-73	potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog	Xenopus laevis	128-133
19582797-6	2009	Analysis of the optimal complex model reveals that the previously identified immunodominant residues Glu(44) and Arg(45) of beta2m have direct interactions with BBM.1, while Asp(38) exerts its function mainly via stabilization of Arg(45).	Aspartic Acid	174-177	beta-2-microglobulin	Homo sapiens	124-130
20149311-3	2009	TRAIL-mediated apoptosis of FLS was quantified by disruption of mitochondrial transmembrane potential (DeltaPsim), Leu-Glu-His-Asp (IETD) ase activity and DNA degradation.	Aspartic Acid	127-130	TNF superfamily member 10	Homo sapiens	0-5
19427400-6	2009	A typical fibronectin type III (FNIII) domain was identified in p48.2 between Arg(176) and Pro(261) in which a palindromic Arg-Gly-Asp (RGD) repeat plus a putative Trp-Ser-X-Trp-Ser (WSXWS) motif were found at the domain"s C-terminus.	Aspartic Acid	131-134	interferon regulatory factor 9	Homo sapiens	64-67
19828635-4	2009	Mutation of glutamate to aspartate almost abolished iNOS activity and reduced dimer formation.	Aspartic Acid	25-34	nitric oxide synthase 2	Homo sapiens	52-56
19706701-3	2009	Since the Tyr-Trp-Thr-Asp beta-propeller domain of LDLR has been shown to be involved in the dissociation of bound LDL via intramolecular competition at low pH, we studied whether it also plays a role in HRV infection.	Aspartic Acid	22-25	low density lipoprotein receptor	Homo sapiens	51-55
19780520-10	2009	We report the results of pK(a) predictions of the aspartic acid 213 of PR3 with a FDPB solver.	Aspartic Acid	50-63	proteinase 3	Homo sapiens	71-74
19740999-4	2009	Furthermore, we showed that alanine substitution in HSV-2 Us3 at a site (aspartic acid at position 147) corresponding to one that can be autophosphorylated in HSV-1 Us3 abolished HSV-2 Us3 kinase activity.	Aspartic Acid	73-86	tegument protein	Human alphaherpesvirus 2	58-61
19740999-4	2009	Furthermore, we showed that alanine substitution in HSV-2 Us3 at a site (aspartic acid at position 147) corresponding to one that can be autophosphorylated in HSV-1 Us3 abolished HSV-2 Us3 kinase activity.	Aspartic Acid	73-86	tegument protein	Human alphaherpesvirus 2	165-168
19740999-4	2009	Furthermore, we showed that alanine substitution in HSV-2 Us3 at a site (aspartic acid at position 147) corresponding to one that can be autophosphorylated in HSV-1 Us3 abolished HSV-2 Us3 kinase activity.	Aspartic Acid	73-86	tegument protein	Human alphaherpesvirus 2	165-168
19797353-8	2009	p,p"-DDT, p,p"-DDE and PCB 138 were significantly associated with the two most prevalent KRAS mutations (Val and Asp).	Aspartic Acid	113-116	pyruvate carboxylase	Homo sapiens	23-26
19797353-8	2009	p,p"-DDT, p,p"-DDE and PCB 138 were significantly associated with the two most prevalent KRAS mutations (Val and Asp).	Aspartic Acid	113-116	KRAS proto-oncogene, GTPase	Homo sapiens	89-93
19822673-6	2009	Synaptic proliferation and retrograde signaling mediated by Syt 4 requires functional C2A and C2B Ca(2+)-binding sites, as well as serine 284, an evolutionarily conserved substitution for a key Ca(2+)-binding aspartic acid found in other synaptotagmins.	Aspartic Acid	209-222	Synaptotagmin 4	Drosophila melanogaster	60-65
19717560-4	2009	Here we demonstrate that mutation of the equivalent serine in mouse lipin-1 and lipin-2 to leucine or aspartate abolishes PAP activity but does not impair lipin association with microsomal membranes, the major site of glycerolipid synthesis.	Aspartic Acid	102-111	lipin 1	Mus musculus	68-75
19717560-4	2009	Here we demonstrate that mutation of the equivalent serine in mouse lipin-1 and lipin-2 to leucine or aspartate abolishes PAP activity but does not impair lipin association with microsomal membranes, the major site of glycerolipid synthesis.	Aspartic Acid	102-111	lipin 2	Mus musculus	80-87
19791743-5	2009	Modeling of the binding mode of 67 suggests that the cyanoguanidine moiety forms charge-assisted hydrogen bonds not only with the conserved Asp-94 but also with the hH4R-specific Arg-341 residue.	Aspartic Acid	140-143	histamine receptor H4	Homo sapiens	165-169
19726788-4	2009	We identified an amino acid substitution at a conserved aspartic acid residue of SMO that had no effect on Hh signaling but disrupted the ability of GDC-0449 to bind SMO and suppress this pathway.	Aspartic Acid	56-69	smoothened, frizzled class receptor	Homo sapiens	81-84
19726788-4	2009	We identified an amino acid substitution at a conserved aspartic acid residue of SMO that had no effect on Hh signaling but disrupted the ability of GDC-0449 to bind SMO and suppress this pathway.	Aspartic Acid	56-69	smoothened, frizzled class receptor	Homo sapiens	166-169
19547991-1	2009	It is well established that only a fraction of Abeta peptides in the brain of Alzheimer"s disease (AD) patients start with N-terminal aspartate (Abeta(1D)) which is generated by proteolytic processing of amyloid precursor protein (APP) by BACE.	Aspartic Acid	134-143	beta-secretase 1	Homo sapiens	239-243
19320425-6	2009	Cd(2+) and Msh2-Msh6 interactions involve cysteine sulfhydryl groups, and the high Cd(2+):Msh2-Msh6 ratio implicates other ligands such as histidine, aspartate, glutamate, and the peptide backbone as well.	Aspartic Acid	150-159	mutS homolog 2	Homo sapiens	90-94
19320425-6	2009	Cd(2+) and Msh2-Msh6 interactions involve cysteine sulfhydryl groups, and the high Cd(2+):Msh2-Msh6 ratio implicates other ligands such as histidine, aspartate, glutamate, and the peptide backbone as well.	Aspartic Acid	150-159	mutS homolog 6	Homo sapiens	95-99
19812345-0	2009	Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription.	Aspartic Acid	51-60	cAMP responsive element binding protein 1	Mus musculus	97-101
19812345-4	2009	Aspartate was identified as the extracellular messenger: enzymatic scavenging of l-aspartate, but not glutamate, blocked stimulation of CREB-dependent gene transcription by cAMP; moreover, cAMP induced aspartate but not glutamate release.	Aspartic Acid	0-9	cAMP responsive element binding protein 1	Mus musculus	136-140
19812345-4	2009	Aspartate was identified as the extracellular messenger: enzymatic scavenging of l-aspartate, but not glutamate, blocked stimulation of CREB-dependent gene transcription by cAMP; moreover, cAMP induced aspartate but not glutamate release.	Aspartic Acid	81-92	cAMP responsive element binding protein 1	Mus musculus	136-140
19812345-4	2009	Aspartate was identified as the extracellular messenger: enzymatic scavenging of l-aspartate, but not glutamate, blocked stimulation of CREB-dependent gene transcription by cAMP; moreover, cAMP induced aspartate but not glutamate release.	Aspartic Acid	83-92	cAMP responsive element binding protein 1	Mus musculus	136-140
19812345-5	2009	Together, these results suggest that cAMP acts via an autocrine or paracrine pathway to release aspartate, which activates NR2B-containing NMDARs, leading to Ca(2+) entry and activation of transcription.	Aspartic Acid	96-105	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	123-127
19804755-3	2009	Genetic, biochemical, and structural analyses of an Nbs1-Ctp1 complex show Nbs1 recruits phosphorylated Ctp1 to DSBs via binding of the Nbs1 FHA domain to a Ctp1 pThr-Asp motif.	Aspartic Acid	167-170	nibrin	Homo sapiens	52-56
19804755-3	2009	Genetic, biochemical, and structural analyses of an Nbs1-Ctp1 complex show Nbs1 recruits phosphorylated Ctp1 to DSBs via binding of the Nbs1 FHA domain to a Ctp1 pThr-Asp motif.	Aspartic Acid	167-170	nibrin	Homo sapiens	75-79
19804755-3	2009	Genetic, biochemical, and structural analyses of an Nbs1-Ctp1 complex show Nbs1 recruits phosphorylated Ctp1 to DSBs via binding of the Nbs1 FHA domain to a Ctp1 pThr-Asp motif.	Aspartic Acid	167-170	nibrin	Homo sapiens	75-79
19804756-4	2009	We demonstrate that diphosphorylated pSer-Asp-pThr-Asp motifs, recently identified as multicopy docking sites within Mdc1, are evolutionarily conserved Nbs1 binding targets.	Aspartic Acid	42-45	mediator of DNA damage checkpoint 1	Homo sapiens	117-121
19804756-4	2009	We demonstrate that diphosphorylated pSer-Asp-pThr-Asp motifs, recently identified as multicopy docking sites within Mdc1, are evolutionarily conserved Nbs1 binding targets.	Aspartic Acid	42-45	nibrin	Homo sapiens	152-156
19654332-3	2009	ASP preferentially cleaves peptide bonds that follow dibasic amino acid residues, as do Kex2 (Saccharomyces cerevisiae serine protease) and furin, which are representative kexin family proteases.	Aspartic Acid	0-3	kexin KEX2	Saccharomyces cerevisiae S288C	88-92
19737145-10	2009	Positional cloning of Cloth-ears identified a point mutation in the neuronal voltage-gated sodium channel alpha-subunit gene, Scn8a, causing an aspartic acid to valine (D981V) change six amino acids downstream of the sixth transmembrane segment of the second domain (D2S6).	Aspartic Acid	144-157	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	126-131
19213874-5	2009	The results demonstrate that insulin-induced hypercontractility after 8 days of tissue culture was fully prevented by combined treatment of BTSM-strips with the laminin competing peptides Tyr-Ile-Gly-Ser-Arg (YIGSR) and Arg-Gly-Asp-Ser (RGDS).	Aspartic Acid	228-231	insulin	Bos taurus	29-36
19812345-6	2009	This cAMP/aspartate/NMDAR signaling pathway may mediate the effects of transmitters such as dopamine on axon growth and synaptogenesis in developing neurons or on synaptic plasticity in mature neural networks.	Aspartic Acid	10-19	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	20-25
19635796-4	2009	The nonconserved amino acid residues in the putative dimer interface of AZI (Ser-277, Ser-331, Glu-332, and Asp-389) were substituted with the corresponding residues in the putative dimer interface of ODC (Arg-277, Tyr-331, Asp-332, and Tyr-389, respectively).	Aspartic Acid	108-111	ornithine decarboxylase antizyme 1	Homo sapiens	72-75
19531501-9	2009	CONCLUSION: These findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the NOS3 may be associated with advanced stage endometriosis in the Korean population.	Aspartic Acid	63-76	nitric oxide synthase 3	Homo sapiens	115-119
19617467-4	2009	We therefore sought to characterize potential phosphorylation sites within the PXR protein by use of a rational, comprehensive, and systematic site-directed mutagenesis approach to generate phosphomimetic mutations (Ser/Thr --&gt; Asp) and phospho-deficient mutations (Ser/Thr --&gt; Ala) at 18 predicted consensus kinase recognition sequences in the human PXR protein.	Aspartic Acid	231-234	nuclear receptor subfamily 1 group I member 2	Homo sapiens	79-82
19767107-1	2009	C5L2 is a recently identified receptor for C5a/C5adesArg, C3a and C3adesArg (ASP).	Aspartic Acid	77-80	complement component 5a receptor 2	Mus musculus	0-4
19767107-1	2009	C5L2 is a recently identified receptor for C5a/C5adesArg, C3a and C3adesArg (ASP).	Aspartic Acid	77-80	hemolytic complement	Mus musculus	43-46
19767107-3	2009	By contrast, some studies demonstrate C3a/ASP binding/activation to C5L2; others do not.	Aspartic Acid	42-45	complement component 5a receptor 2	Mus musculus	68-72
19767107-5	2009	Cell-associated fluorescent-ASP (Fl-ASP) binding to C5L2 increased from transiently transfected&lt;stably transfected&lt;Fl-ASP-sorted C5L2-HEK for both human C5L2 and mouse C5L2.	Aspartic Acid	28-31	complement C5a receptor 2	Homo sapiens	52-56
19767107-5	2009	Cell-associated fluorescent-ASP (Fl-ASP) binding to C5L2 increased from transiently transfected&lt;stably transfected&lt;Fl-ASP-sorted C5L2-HEK for both human C5L2 and mouse C5L2.	Aspartic Acid	28-31	complement C5a receptor 2	Homo sapiens	135-139
19767107-5	2009	Cell-associated fluorescent-ASP (Fl-ASP) binding to C5L2 increased from transiently transfected&lt;stably transfected&lt;Fl-ASP-sorted C5L2-HEK for both human C5L2 and mouse C5L2.	Aspartic Acid	28-31	complement C5a receptor 2	Homo sapiens	135-139
19767107-5	2009	Cell-associated fluorescent-ASP (Fl-ASP) binding to C5L2 increased from transiently transfected&lt;stably transfected&lt;Fl-ASP-sorted C5L2-HEK for both human C5L2 and mouse C5L2.	Aspartic Acid	28-31	complement component 5a receptor 2	Mus musculus	135-139
19767107-5	2009	Cell-associated fluorescent-ASP (Fl-ASP) binding to C5L2 increased from transiently transfected&lt;stably transfected&lt;Fl-ASP-sorted C5L2-HEK for both human C5L2 and mouse C5L2.	Aspartic Acid	36-39	complement C5a receptor 2	Homo sapiens	52-56
19767107-5	2009	Cell-associated fluorescent-ASP (Fl-ASP) binding to C5L2 increased from transiently transfected&lt;stably transfected&lt;Fl-ASP-sorted C5L2-HEK for both human C5L2 and mouse C5L2.	Aspartic Acid	36-39	complement C5a receptor 2	Homo sapiens	135-139
19767107-5	2009	Cell-associated fluorescent-ASP (Fl-ASP) binding to C5L2 increased from transiently transfected&lt;stably transfected&lt;Fl-ASP-sorted C5L2-HEK for both human C5L2 and mouse C5L2.	Aspartic Acid	36-39	complement C5a receptor 2	Homo sapiens	135-139
19767107-5	2009	Cell-associated fluorescent-ASP (Fl-ASP) binding to C5L2 increased from transiently transfected&lt;stably transfected&lt;Fl-ASP-sorted C5L2-HEK for both human C5L2 and mouse C5L2.	Aspartic Acid	36-39	complement component 5a receptor 2	Mus musculus	135-139
19767107-9	2009	In adherent C5L2-HEK (Fl-ASP sorted) and 3T3-L1 cells, blocking with 10% fetal calf serum, protamine sulfate or ovalbumin prevented (125)I-ASP non-specific binding (NSB, no cells), while albumin increased NSB.	Aspartic Acid	25-28	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	112-121
19767107-9	2009	In adherent C5L2-HEK (Fl-ASP sorted) and 3T3-L1 cells, blocking with 10% fetal calf serum, protamine sulfate or ovalbumin prevented (125)I-ASP non-specific binding (NSB, no cells), while albumin increased NSB.	Aspartic Acid	139-142	complement component 5a receptor 2	Mus musculus	12-16
19767107-9	2009	In adherent C5L2-HEK (Fl-ASP sorted) and 3T3-L1 cells, blocking with 10% fetal calf serum, protamine sulfate or ovalbumin prevented (125)I-ASP non-specific binding (NSB, no cells), while albumin increased NSB.	Aspartic Acid	139-142	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	112-121
19767107-13	2009	Recombinant ASP (rASP) produced in modified Escherichia coli Origami (DE3) (allowing folding and disulphide bridge formation), purified under non-denaturing conditions demonstrated 10x greater bioactivity vs. proteolytically derived plasma ASP for triglyceride synthesis and fatty acid uptake in 3T3-L1 adipocytes and preadipocytes while adipose tissue from C5L2 KO mice was non-responsive.	Aspartic Acid	12-15	complement component 5a receptor 2	Mus musculus	358-362
19767107-15	2009	ASP binding has distinct characteristics that lead to C5L2 activation and increased bioactivity.	Aspartic Acid	0-3	complement component 5a receptor 2	Mus musculus	54-58
19676133-5	2009	Among these genes, a nonsynonymous single-nucleotide polymorphism which generates the variation of Gly-137 and Asp-137 in the MMP-7 gene was found to be strongly associated with the development of liver cirrhosis.	Aspartic Acid	111-114	matrix metallopeptidase 7	Homo sapiens	126-131
19676133-6	2009	In contrast to MMP-7(Gly-137) that predominantly secretes out into the cell culture medium, the cirrhosis-associated MMP-7(Asp-137) variant is preferentially localized on the extracellular membranes where it exerts its proteolytic activity on pericellular substrates.	Aspartic Acid	123-126	matrix metallopeptidase 7	Homo sapiens	117-122
19676133-7	2009	Functional analysis demonstrated an increased ability of the MMP-7(Asp-137) variant to associate with the cell surface CD151 molecule.	Aspartic Acid	67-70	matrix metallopeptidase 7	Homo sapiens	61-66
19676133-7	2009	Functional analysis demonstrated an increased ability of the MMP-7(Asp-137) variant to associate with the cell surface CD151 molecule.	Aspartic Acid	67-70	CD151 molecule (Raph blood group)	Homo sapiens	119-124
19676133-8	2009	In wound-healing and Boyden chamber assays, cell motility was specifically enhanced with the expression of MMP-7(Asp-137) as compared to the cells expressing MMP-7(Gly-137).	Aspartic Acid	113-116	matrix metallopeptidase 7	Homo sapiens	107-112
19676133-9	2009	These results demonstrate that the MMP-7(Asp-137) variant confers a gain-of-function phenotype for MMP-7.	Aspartic Acid	41-44	matrix metallopeptidase 7	Homo sapiens	35-40
19676133-9	2009	These results demonstrate that the MMP-7(Asp-137) variant confers a gain-of-function phenotype for MMP-7.	Aspartic Acid	41-44	matrix metallopeptidase 7	Homo sapiens	99-104
19676133-10	2009	CONCLUSION: We have identified a novel genetic association of MMP-7(Asp-137) variant with liver cirrhosis in patients with hepatocellular carcinoma.	Aspartic Acid	68-71	matrix metallopeptidase 7	Homo sapiens	62-67
19775376-2	2009	In comparison to the closest related allele DPB1*0401, HLA-DPB1*2402 has a single nucleotide exchange at position 115 (202), T replaces G. In consequence, codon 39 (68) TAC encodes for tyrosine in the novel allele instead of aspartic acid 39 (68) GAC in DPB1*0401.	Aspartic Acid	225-238	major histocompatibility complex, class II, DP beta 1	Homo sapiens	44-48
19775376-2	2009	In comparison to the closest related allele DPB1*0401, HLA-DPB1*2402 has a single nucleotide exchange at position 115 (202), T replaces G. In consequence, codon 39 (68) TAC encodes for tyrosine in the novel allele instead of aspartic acid 39 (68) GAC in DPB1*0401.	Aspartic Acid	225-238	major histocompatibility complex, class II, DP beta 1	Homo sapiens	55-63
19775376-2	2009	In comparison to the closest related allele DPB1*0401, HLA-DPB1*2402 has a single nucleotide exchange at position 115 (202), T replaces G. In consequence, codon 39 (68) TAC encodes for tyrosine in the novel allele instead of aspartic acid 39 (68) GAC in DPB1*0401.	Aspartic Acid	225-238	major histocompatibility complex, class II, DP beta 1	Homo sapiens	59-63
19596401-2	2009	All ALS-linked SOD1 mutations present with a dominant pattern of inheritance apart from the aspartate to alanine mutation in exon 4 (D90A).	Aspartic Acid	92-101	superoxide dismutase 1	Homo sapiens	15-19
19635796-4	2009	The nonconserved amino acid residues in the putative dimer interface of AZI (Ser-277, Ser-331, Glu-332, and Asp-389) were substituted with the corresponding residues in the putative dimer interface of ODC (Arg-277, Tyr-331, Asp-332, and Tyr-389, respectively).	Aspartic Acid	224-227	ornithine decarboxylase antizyme 1	Homo sapiens	72-75
19635796-4	2009	The nonconserved amino acid residues in the putative dimer interface of AZI (Ser-277, Ser-331, Glu-332, and Asp-389) were substituted with the corresponding residues in the putative dimer interface of ODC (Arg-277, Tyr-331, Asp-332, and Tyr-389, respectively).	Aspartic Acid	224-227	ornithine decarboxylase 1	Homo sapiens	201-204
19670830-6	2009	Decoy agents capable of interrupting the gain of toxic interaction of G93AhSOD1 with MDH1 provide further evidence for the role of malate aspartate shuttle inhibition in G93AhSOD1 toxicity and a promising new route in ALS drug research.	Aspartic Acid	138-147	malate dehydrogenase 1	Homo sapiens	85-89
19706414-3	2009	In vitro cleavage assays demonstrate that OPN is cleaved at Asp-135 and Asp-157 by caspase-8.	Aspartic Acid	60-63	secreted phosphoprotein 1	Homo sapiens	42-45
19706414-3	2009	In vitro cleavage assays demonstrate that OPN is cleaved at Asp-135 and Asp-157 by caspase-8.	Aspartic Acid	60-63	caspase 8	Homo sapiens	83-92
19706414-3	2009	In vitro cleavage assays demonstrate that OPN is cleaved at Asp-135 and Asp-157 by caspase-8.	Aspartic Acid	72-75	secreted phosphoprotein 1	Homo sapiens	42-45
19706414-3	2009	In vitro cleavage assays demonstrate that OPN is cleaved at Asp-135 and Asp-157 by caspase-8.	Aspartic Acid	72-75	caspase 8	Homo sapiens	83-92
19667758-6	2009	The widely shared mutant of cdk6 contains a tyrosine residue at amino acid 224 (instead of an aspartic acid) introducing a potential phosphorylation site to the cdk6 sequence.	Aspartic Acid	94-107	cyclin dependent kinase 6	Homo sapiens	28-32
19665028-7	2009	By site-directed mutagenesis of bovSERPINA3-3, we identified Asp(371) as the potential P1 residue for caspases.	Aspartic Acid	61-64	caspase 8	Homo sapiens	102-110
19450681-3	2009	The caspase cleavage site at aspartic acid D1000 is adjacent to tyrosine Y1001, which when phosphorylated upon MET activation, is involved in CBL recruitment, allowing receptor ubiquitination and down regulation.	Aspartic Acid	29-42	Cbl proto-oncogene	Homo sapiens	142-145
19630420-5	2009	The growth of the Fab-Fc species was proportional to the duration and storage temperature of the incubation period and correlated with the amount of isomerization of the aspartic acid residue preceding lysine 222, determined by peptide mapping.	Aspartic Acid	170-183	FA complementation group B	Homo sapiens	18-21
19667758-6	2009	The widely shared mutant of cdk6 contains a tyrosine residue at amino acid 224 (instead of an aspartic acid) introducing a potential phosphorylation site to the cdk6 sequence.	Aspartic Acid	94-107	cyclin dependent kinase 6	Homo sapiens	161-165
19344310-0	2009	Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.	Aspartic Acid	29-38	insulin	Homo sapiens	137-144
19344310-1	2009	In the present study, we have investigated the effects of the transduction with recombinant adenovirus AdCA-Aralar1 (aspartate-glutamate carrier 1) on the metabolism, function and secretory properties of the glucose- and amino-acid-responsive clonal insulin-secreting cell line BRIN-BD11.	Aspartic Acid	117-126	insulin	Homo sapiens	250-257
19344310-4	2009	These findings indicate that increased malate-aspartate shuttle activity positively shifted beta-cell metabolism, thereby increasing glycolysis capacity, stimulus-secretion coupling and, ultimately, enhancing insulin secretion.	Aspartic Acid	46-55	insulin	Homo sapiens	209-216
19697316-0	2009	CE-LIF chiral separation of aspartic acid and glutamic acid enantiomers using human serum albumin and sodium cholate as dual selectors.	Aspartic Acid	28-41	LIF interleukin 6 family cytokine	Homo sapiens	3-6
19360404-1	2009	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) peptide analogs have been extensively investigated for the imaging of tumor integrin alpha(v)beta(3) and gastrin-releasing peptide receptor (GRPR) expression, respectively.	Aspartic Acid	30-33	integrin subunit alpha V	Homo sapiens	135-159
19360404-1	2009	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) peptide analogs have been extensively investigated for the imaging of tumor integrin alpha(v)beta(3) and gastrin-releasing peptide receptor (GRPR) expression, respectively.	Aspartic Acid	30-33	gastrin releasing peptide receptor	Homo sapiens	164-198
19360404-1	2009	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) peptide analogs have been extensively investigated for the imaging of tumor integrin alpha(v)beta(3) and gastrin-releasing peptide receptor (GRPR) expression, respectively.	Aspartic Acid	30-33	gastrin releasing peptide receptor	Homo sapiens	200-204
19690383-8	2009	Mutation of these target serines to aspartate, in order to mimic phosphorylation, attenuated the effect of WNK4 on NCC activity in the Xenopus oocyte system.	Aspartic Acid	36-45	WNK lysine deficient protein kinase 4	Homo sapiens	107-111
19531496-5	2009	The residue Asp-993, mutated in ALI5, is a conserved residue in the catalytic domain of PLC enzymes.	Aspartic Acid	12-15	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	88-91
19811225-4	2009	Using a panel of pharmacological inhibitors of serine, cysteine, aspartate, or metalloproteinases, preliminary evidence is presented for the hypothesis that matrix metalloproteinase-2 (MMP-2) might be the protease, primarily responsible for CD40L cleavage from platelet surface.	Aspartic Acid	65-74	matrix metallopeptidase 2	Homo sapiens	157-183
19811225-4	2009	Using a panel of pharmacological inhibitors of serine, cysteine, aspartate, or metalloproteinases, preliminary evidence is presented for the hypothesis that matrix metalloproteinase-2 (MMP-2) might be the protease, primarily responsible for CD40L cleavage from platelet surface.	Aspartic Acid	65-74	matrix metallopeptidase 2	Homo sapiens	185-190
19615750-6	2009	RESULTS: stably transfected C5L2-HEK cells were sorted using fluorescent-ASP (Fluos-ASP) binding.	Aspartic Acid	73-76	complement C5a receptor 2	Homo sapiens	28-32
19615750-13	2009	While S323I-C5L2 was competent for Fluos-ASP and (125)I-ASP binding, although at a reduced level, there was no ligand-mediated receptor phosphorylation.	Aspartic Acid	41-44	complement C5a receptor 2	Homo sapiens	12-16
19615750-13	2009	While S323I-C5L2 was competent for Fluos-ASP and (125)I-ASP binding, although at a reduced level, there was no ligand-mediated receptor phosphorylation.	Aspartic Acid	56-59	complement C5a receptor 2	Homo sapiens	12-16
19307045-2	2009	Their encoded proteins, SMAP1 and SMAP2, are similar in calculated molecular weight and isoelectric point, and in having a highly conserved phenylalanine and aspartic acid-rich domain.	Aspartic Acid	158-171	small acidic protein 1	Arabidopsis thaliana	24-29
19552406-0	2009	Evaluation of a novel Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for potential melanoma therapy.	Aspartic Acid	30-33	pro-opiomelanocortin-alpha	Mus musculus	45-81
19307045-2	2009	Their encoded proteins, SMAP1 and SMAP2, are similar in calculated molecular weight and isoelectric point, and in having a highly conserved phenylalanine and aspartic acid-rich domain.	Aspartic Acid	158-171	small acidic protein 2	Arabidopsis thaliana	34-39
19528234-5	2009	A strain containing a threonine-to-alanine mutation at a conserved Cdc28 phosphorylation site of Efg1 displays a loss of hypha-specific repression of these genes and impaired cell chain formation, mimicking the hgc1 deletion, whereas a strain containing the threonine to aspartic acid mutation leads to a downregulation of these genes and cell chain formation during yeast growth.	Aspartic Acid	271-284	Efg1p	Saccharomyces cerevisiae S288C	97-101
19555118-8	2009	Analysis of the arrestin2 structure reveals that Arg-7, Lys-10, and Lys-11 are in close proximity to Glu-389 and Asp-390, suggesting that these residues may form intramolecular interactions.	Aspartic Acid	113-116	arrestin beta 1	Homo sapiens	16-25
19667215-0	2009	Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.	Aspartic Acid	80-89	neuronal pentraxin 2	Homo sapiens	6-10
19555410-2	2009	Phenotypic analysis revealed a high level of photorespiratory ammonium, glutamine/glutamate and asparagine/aspartate in the GLU1 mutant lacking the major ferredoxin-glutamate synthase, indicating that excess photorespiratory ammonium was detoxified into amino acids for transport out of the veins.	Aspartic Acid	107-116	glutamate synthase 1	Arabidopsis thaliana	124-128
19157633-8	2009	The polymorphism of XPG 46His/His was found to be associated with clinical response in NSCLC patients P=0.047, not detected between chemotherapy response and SNPs of XRCC1 399Arg/Gln or XPG 1104His/Asp (P=0.997 0.561, respectively).	Aspartic Acid	198-201	ERCC excision repair 5, endonuclease	Homo sapiens	20-23
19470763-7	2009	Substitution of Ser10 with the phosphorylation mimic aspartic acid selectively impairs RUNX-1 binding, abrogates transcriptional synergy with RUNX-1, and dominantly inhibits primary fetal liver megakaryocyte differentiation in vitro.	Aspartic Acid	53-66	runt related transcription factor 1	Mus musculus	87-93
19470763-7	2009	Substitution of Ser10 with the phosphorylation mimic aspartic acid selectively impairs RUNX-1 binding, abrogates transcriptional synergy with RUNX-1, and dominantly inhibits primary fetal liver megakaryocyte differentiation in vitro.	Aspartic Acid	53-66	runt related transcription factor 1	Mus musculus	142-148
19527069-7	2009	Alteration of N-terminal SSB-Ct residues leads to changes that reflect cumulative electrostatic binding roles for the Asp residues in SSB-Ct.	Aspartic Acid	118-121	single-stranded DNA-binding protein	Escherichia coli	25-31
19641205-1	2009	The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), specific to neurons and muscle, supplies aspartate to the cytosol and, as a component of the malate-aspartate shuttle, enables mitochondrial oxidation of cytosolic NADH, thought to be important in providing energy for neurons in the central nervous system.	Aspartic Acid	18-27	solute carrier family 25 member 12	Homo sapiens	57-61
19641205-1	2009	The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), specific to neurons and muscle, supplies aspartate to the cytosol and, as a component of the malate-aspartate shuttle, enables mitochondrial oxidation of cytosolic NADH, thought to be important in providing energy for neurons in the central nervous system.	Aspartic Acid	105-114	solute carrier family 25 member 12	Homo sapiens	57-61
19641205-1	2009	The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), specific to neurons and muscle, supplies aspartate to the cytosol and, as a component of the malate-aspartate shuttle, enables mitochondrial oxidation of cytosolic NADH, thought to be important in providing energy for neurons in the central nervous system.	Aspartic Acid	105-114	solute carrier family 25 member 12	Homo sapiens	57-61
19506028-4	2009	The high density of aspartate and glutamate residues on the surface follow a helical pattern and the whole protein mimics a 42-base pair stretch of B-form DNA making ArdA by far the largest DNA mimic known.	Aspartic Acid	20-29	ArdA	Escherichia coli	166-170
19527069-7	2009	Alteration of N-terminal SSB-Ct residues leads to changes that reflect cumulative electrostatic binding roles for the Asp residues in SSB-Ct.	Aspartic Acid	118-121	single-stranded DNA-binding protein	Escherichia coli	134-140
19447885-6	2009	Electrophysiological studies showed that the key residues for functional activity are Asp(5)-Arg(7) and Asp(11)-Ile(15), because changes at these positions resulted in the loss of activity at the alpha9alpha10 nAChR.	Aspartic Acid	86-89	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	210-215
19594936-12	2009	A structural analysis of the 10-bladed beta-propeller fold, which has so far only been observed in the Asp-box family, reveals that the inner strands of the blades are unusually far apart, which explains the surprisingly large diameter of the central tunnel of sortilin.	Aspartic Acid	103-106	sortilin 1	Homo sapiens	261-269
19473974-6	2009	Mutations targeting the Glu(137)-Glu-Asp(139) stretch in the C1r EGF module had no effect on C1 assembly, ruling out our previous interaction model.	Aspartic Acid	37-40	complement C1r	Homo sapiens	61-64
19494832-5	2009	Furthermore, after an intramolecular rearrangement of MccA-acyl-adenylate, MccB catalyses a second, unique reaction, producing a stable phosphoramidate-linked analogue of acyl-adenylated aspartic acid.	Aspartic Acid	187-200	MccB	Escherichia coli	75-79
19457063-5	2009	Our results suggest that the change in aspartate-glutamate homeostasis is due to a decreased availability of NADH for cytosolic malate dehydrogenase and thus reduced malate-aspartate shuttle activity in neurons using beta-hydroxybutyrate.	Aspartic Acid	39-48	malate dehydrogenase 1	Homo sapiens	118-148
19341362-3	2009	Glutamine, a mixture of leucine, aspartic acid and glycine, and a mixture of leucine, glutamine and aspartic acid, were the most effective for the expression of IL-2.	Aspartic Acid	33-46	interleukin 2	Homo sapiens	161-165
19341362-3	2009	Glutamine, a mixture of leucine, aspartic acid and glycine, and a mixture of leucine, glutamine and aspartic acid, were the most effective for the expression of IL-2.	Aspartic Acid	100-113	interleukin 2	Homo sapiens	161-165
19411703-7	2009	We also find that specific interactions with Cdc50p are required to render the ATPase competent for phosphorylation at the catalytically important aspartate residue.	Aspartic Acid	147-156	aminophospholipid translocase regulatory protein CDC50	Saccharomyces cerevisiae S288C	45-51
19574740-7	2009	Furthermore, it was found that STIM1 gates TRPC channels by electrostatic interaction of STIM1(K684,K685) in the polybasic domain of STIM1 with two negative charges (aspartates or glutamates) that are conserved in all TRPC channels.	Aspartic Acid	166-176	stromal interaction molecule 1	Homo sapiens	31-36
19574740-7	2009	Furthermore, it was found that STIM1 gates TRPC channels by electrostatic interaction of STIM1(K684,K685) in the polybasic domain of STIM1 with two negative charges (aspartates or glutamates) that are conserved in all TRPC channels.	Aspartic Acid	166-176	stromal interaction molecule 1	Homo sapiens	89-94
19574740-7	2009	Furthermore, it was found that STIM1 gates TRPC channels by electrostatic interaction of STIM1(K684,K685) in the polybasic domain of STIM1 with two negative charges (aspartates or glutamates) that are conserved in all TRPC channels.	Aspartic Acid	166-176	stromal interaction molecule 1	Homo sapiens	89-94
19401151-2	2009	sL1 is a ligand for several Arg-Gly-Asp (RGD)-binding integrins and can be deposited in the extracellular matrix.	Aspartic Acid	36-39	TATA-box binding protein associated factor, RNA polymerase I subunit A	Homo sapiens	0-3
19373110-9	2009	With regard to the Glu298Asp polymorphism in NOS3, the odds ratio for the presence of hypertension in individuals having the Glu/Glu genotype of NOS3 when compared with those having the other genotypes (Asp/Asp and Asp/Glu) was 2.79.	Aspartic Acid	25-28	nitric oxide synthase 3	Homo sapiens	45-49
19373110-9	2009	With regard to the Glu298Asp polymorphism in NOS3, the odds ratio for the presence of hypertension in individuals having the Glu/Glu genotype of NOS3 when compared with those having the other genotypes (Asp/Asp and Asp/Glu) was 2.79.	Aspartic Acid	25-28	nitric oxide synthase 3	Homo sapiens	145-149
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Aspartic Acid	86-89	fibronectin 1	Homo sapiens	121-123
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Aspartic Acid	86-89	G protein-coupled estrogen receptor 1	Homo sapiens	147-152
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Aspartic Acid	86-89	epidermal growth factor receptor	Homo sapiens	162-194
19322026-1	2009	Triple A syndrome is a rare genetic disorder caused by mutations in the achalasia-addisonianism-alacrima syndrome (AAAS) gene which encodes a tryptophan aspartic acid (WD) repeat-containing protein named alacrima-achalasia-adrenal insufficiency neurologic disorder (ALADIN).	Aspartic Acid	153-166	aladin WD repeat nucleoporin	Homo sapiens	115-119
19568421-7	2009	Site-directed mutagenesis demonstrated that His(127), Asp(156) and Ser(263) in Domain 1 form the catalytic triad of EspP.	Aspartic Acid	54-57	extracellular serine protease (autotransporter)	Escherichia coli	116-120
19322026-1	2009	Triple A syndrome is a rare genetic disorder caused by mutations in the achalasia-addisonianism-alacrima syndrome (AAAS) gene which encodes a tryptophan aspartic acid (WD) repeat-containing protein named alacrima-achalasia-adrenal insufficiency neurologic disorder (ALADIN).	Aspartic Acid	153-166	aladin WD repeat nucleoporin	Homo sapiens	204-264
19322026-1	2009	Triple A syndrome is a rare genetic disorder caused by mutations in the achalasia-addisonianism-alacrima syndrome (AAAS) gene which encodes a tryptophan aspartic acid (WD) repeat-containing protein named alacrima-achalasia-adrenal insufficiency neurologic disorder (ALADIN).	Aspartic Acid	153-166	aladin WD repeat nucleoporin	Homo sapiens	266-272
19553454-9	2009	The effects of protein kinase inhibitors on [(3)H]D-aspartate uptake indicated the selective involvement of Src kinases, which are probably a component of the Na,K-ATPase/glutamate transporter complex.	Aspartic Acid	52-61	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	108-111
19318085-9	2009	Instead, we find elevation of a Fab+Fc fragment that began with aspartic acid (cleavage between C/D).	Aspartic Acid	64-77	FA complementation group B	Homo sapiens	32-35
19395377-7	2009	IaI heavy chains contain von Willebrand A domains that can bind the arginine-glycine-aspartate domain of vitronectin.	Aspartic Acid	85-94	vitronectin	Mus musculus	105-116
19395377-9	2009	We show that IaI binds vitronectin at the arginine-glycine-aspartate site, thereby promoting epithelial adhesion and migration in vitro.	Aspartic Acid	59-68	vitronectin	Mus musculus	23-34
19446064-2	2009	The antigen, transferrin, specifically bound to the membrane-immobilized antibody and was eluted only after rinsing the membrane with glutamic acid or aspartic acid solution.	Aspartic Acid	151-164	transferrin	Homo sapiens	13-24
19446064-4	2009	The transferrin extracted by glutamic acid or aspartic acid solution retained the binding of Fe3+ in the presence of the carbonate anion.	Aspartic Acid	46-59	transferrin	Homo sapiens	4-15
19129013-5	2009	In this study, we hypothesized that PES surfaces modified with a peptide sequence based from fibronectin, such as Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser and Gly-Arg-Gly-Asp-Ser, would increase ASC adhesion compared to unmodified PES surfaces.	Aspartic Acid	122-125	fibronectin 1	Homo sapiens	93-104
19336397-0	2009	Mutation of Aspartate 555 of the Sodium/Bicarbonate Transporter SLC4A4/NBCe1 Induces Chloride Transport.	Aspartic Acid	12-21	solute carrier family 4 member 4	Homo sapiens	64-70
19284778-3	2009	For one such hit class, defined by a central aminobenzylpiperidine (ABP) moiety, X-ray crystal structures of BACE mutant-disulfide conjugates revealed that the fragment bound by engaging both catalytic aspartates with hydrogen bonds.	Aspartic Acid	202-212	beta-secretase 1	Homo sapiens	109-113
19528510-4	2009	RESULTS: Individuals carrying the APE1 Asp148Glu heterozygous and homozygous variant genotype had a 3.23-fold increased risk of lung cancer compared with these carrying the wild-type (Asp/Asp) genotype (p&lt;0.0001), and those carrying the 148Glu homozygous genotype had a 3.17-fold increased risk (p=0.023).	Aspartic Acid	39-42	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	34-38
19439663-5	2009	We show that full-length IL-33(1-270) binds and activates ST2, similarly to IL-33(112-270), and that cleavage by caspase-1 does not occur at the site initially proposed (Ser(111)), but rather after residue Asp(178) between the fourth and fifth predicted beta-strands of the IL-1-like domain.	Aspartic Acid	206-209	interleukin 33	Homo sapiens	25-30
19439663-5	2009	We show that full-length IL-33(1-270) binds and activates ST2, similarly to IL-33(112-270), and that cleavage by caspase-1 does not occur at the site initially proposed (Ser(111)), but rather after residue Asp(178) between the fourth and fifth predicted beta-strands of the IL-1-like domain.	Aspartic Acid	206-209	caspase 1	Homo sapiens	113-122
19528510-4	2009	RESULTS: Individuals carrying the APE1 Asp148Glu heterozygous and homozygous variant genotype had a 3.23-fold increased risk of lung cancer compared with these carrying the wild-type (Asp/Asp) genotype (p&lt;0.0001), and those carrying the 148Glu homozygous genotype had a 3.17-fold increased risk (p=0.023).	Aspartic Acid	184-187	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	34-38
18553220-5	2009	Carriers of the BRCA2 rs1799944 variant (991 Asp) were found to have an increased risk of breast cancer (OR = 1.41, 95% CI 1.08-1.83, P = 0.01) with P (trend) = 0.0076.	Aspartic Acid	45-48	BRCA2 DNA repair associated	Homo sapiens	16-21
19378355-1	2009	Several novel bradykinin B1 receptor (B1R) antagonists were synthesized utilizing a new aspartic acid scaffold.	Aspartic Acid	88-101	bradykinin receptor B1	Homo sapiens	14-36
19504859-1	2009	The adsorption mechanism of dipeptides namely Gly-Glu, Asp-Glu with protein layer was successfully examined on cytochrome c (Cyt.c) surface probing by fluorescent dye molecule.	Aspartic Acid	55-58	cytochrome c, somatic	Homo sapiens	111-123
19504859-1	2009	The adsorption mechanism of dipeptides namely Gly-Glu, Asp-Glu with protein layer was successfully examined on cytochrome c (Cyt.c) surface probing by fluorescent dye molecule.	Aspartic Acid	55-58	cytochrome c, somatic	Homo sapiens	125-130
19519483-4	2009	DARC is an unorthodox chemokine receptor as (i) it binds chemokines of both CC and CXC classes and (ii) it lacks the Asp-Arg-Tyr consensus motif in its second cytoplasmic loop hence cannot couple to G proteins and activate their signaling pathways.	Aspartic Acid	117-120	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	0-4
19378355-1	2009	Several novel bradykinin B1 receptor (B1R) antagonists were synthesized utilizing a new aspartic acid scaffold.	Aspartic Acid	88-101	bradykinin receptor B1	Homo sapiens	38-41
19301871-6	2009	The presence of the intact substrate in the GCPII(E424A) binding cavity substantiates our kinetic data and allows a detailed analysis of GCPII/N-Ac-Asp-Glu interactions.	Aspartic Acid	148-151	folate hydrolase 1	Homo sapiens	44-49
19318353-5	2009	Mutational analysis of AFABP/aP2 (R126L/Y128F) revealed that fatty acid binding activity is necessary for the interaction and that Asp(18) of the helix-turn-helix motif forms a component of the interaction domain.	Aspartic Acid	131-134	fatty acid binding protein 4, adipocyte	Mus musculus	23-28
19318353-5	2009	Mutational analysis of AFABP/aP2 (R126L/Y128F) revealed that fatty acid binding activity is necessary for the interaction and that Asp(18) of the helix-turn-helix motif forms a component of the interaction domain.	Aspartic Acid	131-134	fatty acid binding protein 4, adipocyte	Mus musculus	29-32
19361221-7	2009	Our results suggest that (1) the proline residue has a role in both specificity and phospho transfer efficiency, (2) the reaction occurs in one step, with ERK2 Asp(147) acting as the catalytic base, (3) a conserved Lys in the kinase superfamily that is usually mutated to check kinase activity strongly stabilizes the transition state, and (4) the reaction mechanism is similar with either one or two Mg(2+) ions in the active site.	Aspartic Acid	160-163	mitogen-activated protein kinase 1	Homo sapiens	155-159
19281794-4	2009	Using site-directed mutagenesis analyses, the aspartic acid residues at positions 97 and 151 of PU.1 protein were identified as capsase-3 target sites.	Aspartic Acid	46-59	Spi-1 proto-oncogene	Homo sapiens	96-100
19446523-4	2009	The structure reveals a detailed network of interactions between the protein and the amino-terminal residues of histone H3, and particularly key electrostatic interactions of a conserved aspartic acid 297 in AIRE with the unmodified lysine 4 of histone H3 (H3K4).	Aspartic Acid	187-200	autoimmune regulator	Homo sapiens	208-212
19283487-2	2009	Asp is the most frequent P4 residue in peptide substrates, although a wide variety of P4 residues are found in the cellular proteins cleaved by caspase-3.	Aspartic Acid	0-3	caspase 3	Homo sapiens	144-153
19283487-6	2009	These interactions of hydrophobic P4 residues are distinct from those for polar P4 Asp, which indicates the adaptability of caspase-3 for binding diverse P4 residues.	Aspartic Acid	83-86	caspase 3	Homo sapiens	124-133
19232506-0	2009	Sustaining hypercitrullinemia, hypercholesterolemia and augmented oxidative stress in Japanese children with aspartate/glutamate carrier isoform 2-citrin-deficiency even during the silent period.	Aspartic Acid	109-118	solute carrier family 25 member 13	Homo sapiens	147-153
19342873-4	2009	However, P-gp contain many aspartate residues which could be targeted by caspases other than caspase-3.	Aspartic Acid	27-36	ATP binding cassette subfamily B member 1	Homo sapiens	9-13
19342873-4	2009	However, P-gp contain many aspartate residues which could be targeted by caspases other than caspase-3.	Aspartic Acid	27-36	caspase 6	Homo sapiens	73-81
19342873-4	2009	However, P-gp contain many aspartate residues which could be targeted by caspases other than caspase-3.	Aspartic Acid	27-36	caspase 3	Homo sapiens	93-102
19326097-3	2009	Bioinformatic analysis revealed that VVA0331 consist of nineteen 87-amino acid repeats, two Arg-Gly-Asp motifs, four cysteine residues, an outer membrane protein domain, a polysaccharide-binding site and several motifs related to cell adhesions.	Aspartic Acid	100-103	BJE04_RS17365	Vibrio vulnificus YJ016	37-44
19304952-2	2009	Skn7 osmotic stress activity depends on the phosphorylation of the receiver domain aspartate, D427, by the Sln1 histidine kinase.	Aspartic Acid	83-92	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	0-4
19304952-2	2009	Skn7 osmotic stress activity depends on the phosphorylation of the receiver domain aspartate, D427, by the Sln1 histidine kinase.	Aspartic Acid	83-92	histidine kinase	Saccharomyces cerevisiae S288C	107-111
18946634-6	2009	Allelic frequencies in wild type of XRCC1 C26304T were 91.1% C(Arg); G27466A 62.9% G(Arg); G23591A 60.3% G(Arg); APE1 T2197G 75.1% T(Asp) and XPD A35931C 71.8% A(Lys).	Aspartic Acid	133-136	X-ray repair cross complementing 1	Homo sapiens	36-41
19389946-5	2009	Besides known biologically active peptides, exclusive peptides were identified in some CSN3 variants and their biological activity was determined: within CSN3*B and CSN3*C, the ACE inhibitory peptide ASP (IC50 = 242.3; the IC50 value is equivalent to the micromolar concentration of peptide mediating a 50% inhibition of ACE activity) and within CSN3*C the peptide AHHP (IC50 = 847.6) was detected.	Aspartic Acid	200-203	casein kappa	Bos taurus	87-91
19389946-5	2009	Besides known biologically active peptides, exclusive peptides were identified in some CSN3 variants and their biological activity was determined: within CSN3*B and CSN3*C, the ACE inhibitory peptide ASP (IC50 = 242.3; the IC50 value is equivalent to the micromolar concentration of peptide mediating a 50% inhibition of ACE activity) and within CSN3*C the peptide AHHP (IC50 = 847.6) was detected.	Aspartic Acid	200-203	angiotensin I converting enzyme	Bos taurus	177-180
19389946-5	2009	Besides known biologically active peptides, exclusive peptides were identified in some CSN3 variants and their biological activity was determined: within CSN3*B and CSN3*C, the ACE inhibitory peptide ASP (IC50 = 242.3; the IC50 value is equivalent to the micromolar concentration of peptide mediating a 50% inhibition of ACE activity) and within CSN3*C the peptide AHHP (IC50 = 847.6) was detected.	Aspartic Acid	200-203	angiotensin I converting enzyme	Bos taurus	321-324
19232506-4	2009	We analyzed oxidative stress markers and profiles of amino acids, carbohydrates, and lipids in 20 asymptomatic children with aspartate/glutamate carrier isoform 2-citrin-deficiency aged 1-10 years, for whom tests showed normal liver function.	Aspartic Acid	125-134	solute carrier family 25 member 13	Homo sapiens	163-169
19153083-3	2009	Asp(26) and Asp(29) in the N-terminal domain of betaarrestin1 are critical for its binding to MEK1, whereas Arg(47) and Arg(49) in the N-terminal domain of MEK1 are critical for its binding to betaarrestin1.	Aspartic Acid	0-3	arrestin beta 1	Homo sapiens	48-61
19259068-2	2009	We have developed a peptide-like scaffold (regioselectively addressable functionalized template, RAFT), which holds four cyclo(-RGDfK-) (cRGD) motifs and proved that this molecule (called regioselectively addressable functionalized template-arginine-glycine-aspartic acid, RAFT-RGD) targets integrin alpha(v)beta(3) in vitro and in vivo.	Aspartic Acid	258-271	integrin subunit alpha V	Homo sapiens	291-314
19400947-3	2009	HLS is caused by a substitution of aspartic acid by glycine in the HYLS1 protein, whose function was previously unknown.	Aspartic Acid	35-48	HYLS1 centriolar and ciliogenesis associated	Homo sapiens	0-3
19400947-3	2009	HLS is caused by a substitution of aspartic acid by glycine in the HYLS1 protein, whose function was previously unknown.	Aspartic Acid	35-48	HYLS1 centriolar and ciliogenesis associated	Homo sapiens	67-72
19225180-7	2009	Experiments using concanavalin-A to directly report conformations in the intact GluK2 receptor support this prediction with the full agonist, L-Glu, indistinguishable in this regard from weak partial agonists, D- and L-Asp.	Aspartic Acid	217-222	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	80-85
19235198-2	2009	Here, fluorescence derby imaging using dual color QDs conjugated by the AS1411 aptamer (targeting nucleolin) and the arginine-glycine-aspartic acid (targeting the integrin alpha(v)beta(3)) in cancer cells is reported.	Aspartic Acid	134-147	integrin subunit alpha V	Homo sapiens	163-187
19228119-10	2009	Phosphorylation activated AtPPC1 at pH 7.3 by lowering its Km(PEP) and its sensitivity to inhibition by L-malate and L-aspartate, while enhancing activation by glucose 6-phosphate.	Aspartic Acid	117-128	phosphoenolpyruvate carboxylase 1	Arabidopsis thaliana	26-32
19228120-6	2009	Examination of the TRPM7 kinase domain structure suggests that the activation sequence interacts with the other subunit to help position a catalytic loop that contains the invariant Asp-1765 residue.	Aspartic Acid	182-185	transient receptor potential cation channel subfamily M member 7	Homo sapiens	19-24
19153083-3	2009	Asp(26) and Asp(29) in the N-terminal domain of betaarrestin1 are critical for its binding to MEK1, whereas Arg(47) and Arg(49) in the N-terminal domain of MEK1 are critical for its binding to betaarrestin1.	Aspartic Acid	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	94-98
19153083-3	2009	Asp(26) and Asp(29) in the N-terminal domain of betaarrestin1 are critical for its binding to MEK1, whereas Arg(47) and Arg(49) in the N-terminal domain of MEK1 are critical for its binding to betaarrestin1.	Aspartic Acid	12-15	arrestin beta 1	Homo sapiens	48-61
19386107-2	2009	This model is particularly relevant to cancer cell metastasis to bone since BSP, bound to the alphavbeta3 integrin through its arginine-glycine-aspartic acid motif, could recruit MMP-2 to the cell surface.	Aspartic Acid	144-157	integrin binding sialoprotein	Homo sapiens	76-79
19265705-2	2009	4.1.1.12) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme that catalyzes the beta-decarboxylation of l-aspartate to produce l-alanine and CO(2).	Aspartic Acid	104-115	pyridoxal phosphatase	Homo sapiens	15-37
19265705-2	2009	4.1.1.12) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme that catalyzes the beta-decarboxylation of l-aspartate to produce l-alanine and CO(2).	Aspartic Acid	104-115	pyridoxal phosphatase	Homo sapiens	39-42
19099536-9	2009	Mechanistically, both ROCK2 activity and dimerization were dependent upon the interaction between Thr(405) of the hydrophobic motif and Asp(39) of the N-terminal extension.	Aspartic Acid	136-139	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-27
19228693-8	2009	The obtained structure has revealed that the central part of pep-10L (Asp(5)-Phe(9)) has a helical conformation, the side chains of Trp(6), Leu(7), and Phe(9) form a hydrophobic side in the helix, and the Tyr(8) side chain faces the opposite direction from the hydrophobic side.	Aspartic Acid	70-73	transient receptor potential cation channel subfamily C member 6	Homo sapiens	132-138
19228693-8	2009	The obtained structure has revealed that the central part of pep-10L (Asp(5)-Phe(9)) has a helical conformation, the side chains of Trp(6), Leu(7), and Phe(9) form a hydrophobic side in the helix, and the Tyr(8) side chain faces the opposite direction from the hydrophobic side.	Aspartic Acid	70-73	beta-1,3-glucuronyltransferase 1	Homo sapiens	140-145
19224859-5	2009	The Drosophila effector caspase Drice cleaves dSREBP, and cleavage requires an Asp residue at position 386, in the cytoplasmic juxtamembrane stalk.	Aspartic Acid	79-82	Death related ICE-like caspase	Drosophila melanogaster	32-37
19224862-4	2009	The crystal structure of the PCSK9-EGF-A(H306Y) complex shows that Tyr-306 forms a hydrogen bond with Asp-374 in PCSK9 at neutral pH, which strengthens the interaction with PCSK9.	Aspartic Acid	102-105	proprotein convertase subtilisin/kexin type 9	Homo sapiens	29-34
19224862-4	2009	The crystal structure of the PCSK9-EGF-A(H306Y) complex shows that Tyr-306 forms a hydrogen bond with Asp-374 in PCSK9 at neutral pH, which strengthens the interaction with PCSK9.	Aspartic Acid	102-105	proprotein convertase subtilisin/kexin type 9	Homo sapiens	113-118
19224862-4	2009	The crystal structure of the PCSK9-EGF-A(H306Y) complex shows that Tyr-306 forms a hydrogen bond with Asp-374 in PCSK9 at neutral pH, which strengthens the interaction with PCSK9.	Aspartic Acid	102-105	proprotein convertase subtilisin/kexin type 9	Homo sapiens	113-118
19368885-1	2009	The type-I PLP enzyme l-aspartate beta-decarboxylase converts aspartate to alanine and CO(2).	Aspartic Acid	24-33	proteolipid protein 1	Homo sapiens	11-14
19000660-4	2009	In another member of the superfamily (ALDH3) this serine residue is an aspartate, which tethers the "distal" Lys.	Aspartic Acid	71-80	aldehyde dehydrogenase 3 family member A1	Homo sapiens	38-43
19139090-6	2009	Alanine substitutions at Glu(12), Asp(15), Phe(19), Leu(53), and Glu(57) analogues resulted in significant (&gt;2-fold) decreases in affinity for both the IGF-1R and IR.	Aspartic Acid	34-37	insulin like growth factor 1 receptor	Homo sapiens	155-161
19348010-7	2009	Compared to alpha-sarcin, HtA has an aspartate group, D40, replacing a tyrosine, and the aromatic ring of F126, located in the leucine "environment" close to the catalytic H113 in a similar arrangement to that found in RNase T1.	Aspartic Acid	37-46	hepatocellular carcinoma associated transcript 5	Homo sapiens	26-29
19181704-7	2009	D70 of APE1 aligns with A138 of LMAP and mutation of the latter to aspartate significantly reduces its 3"-phosphodiesterase activity.	Aspartic Acid	67-76	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	7-11
18789468-3	2009	Fibrillin-1 contains the Arg-Gly-Asp (RGD) motif, which may allow binding to RGD-recognizing integrins.	Aspartic Acid	33-36	fibrillin 1	Homo sapiens	0-11
19191736-7	2009	Those residues responsible for anchoring the hexose moieties of the dTDP-sugars to the protein include Glu 141, Asn 159, and Asp 160 from one subunit and His 134 from another subunit.	Aspartic Acid	125-128	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	68-72
19120039-5	2009	However, in the African Americans, a non-synonymous single nucleotide polymorphism (i.e. an aspartic acid/glycine coding variant, rs2856966) within exon 2 of PACAP was significantly associated with SIDS (p = 0.004), as were haplotypes containing this polymorphism (p &lt; 0.0001).	Aspartic Acid	92-105	adenylate cyclase activating polypeptide 1	Homo sapiens	158-163
19278658-1	2009	Caspases are proteases with an active-site cysteine and aspartate specificity in their substrates.	Aspartic Acid	56-65	caspase 8	Homo sapiens	0-8
19041899-9	2009	Results indicate that subchronic D-Asp or DEE (i) reduced EAA levels in the NHE and increased it in the random-bred controls (NRB) rats, (ii) in the Lat-maze D-Asp increased horizontal activity in NHE but DEE decreased it in NRB rats, (iii) in the Olton maze D-Asp and DEE decreased vertical activity in NHE and NRB rats respectively, (iv) D-Asp impaired attention only in NRB decreasing number of arms visited before first repetition.	Aspartic Acid	35-38	linker for activation of T cells	Rattus norvegicus	149-152
19041899-9	2009	Results indicate that subchronic D-Asp or DEE (i) reduced EAA levels in the NHE and increased it in the random-bred controls (NRB) rats, (ii) in the Lat-maze D-Asp increased horizontal activity in NHE but DEE decreased it in NRB rats, (iii) in the Olton maze D-Asp and DEE decreased vertical activity in NHE and NRB rats respectively, (iv) D-Asp impaired attention only in NRB decreasing number of arms visited before first repetition.	Aspartic Acid	160-163	linker for activation of T cells	Rattus norvegicus	149-152
19041899-9	2009	Results indicate that subchronic D-Asp or DEE (i) reduced EAA levels in the NHE and increased it in the random-bred controls (NRB) rats, (ii) in the Lat-maze D-Asp increased horizontal activity in NHE but DEE decreased it in NRB rats, (iii) in the Olton maze D-Asp and DEE decreased vertical activity in NHE and NRB rats respectively, (iv) D-Asp impaired attention only in NRB decreasing number of arms visited before first repetition.	Aspartic Acid	160-163	linker for activation of T cells	Rattus norvegicus	149-152
19106102-6	2009	In contrast, substitution of distal Glu and Asp residues with Gly or their deletion resulted in pro-Crp4-(20-92) variants with bactericidal and membrane-disruptive activities equal to or greater than that of fully mature Crp4.	Aspartic Acid	44-47	defensin, alpha, 4	Mus musculus	100-104
19112175-6	2009	The compromised vesicle binding by mutants in the key asparate residues forming the structural Mg2+-aspartate-water network within the substrate binding domain revealed that interfacial binding of DgkB required a Mg2+-dependent conformational change.	Aspartic Acid	100-109	diacylglycerol kinase beta	Homo sapiens	197-201
19116204-1	2009	The single nucleotide polymorphism 118A>G of the human micro-opioid receptor gene OPRM1, which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position 40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees in pain-processing brain regions.	Aspartic Acid	152-165	opioid receptor mu 1	Homo sapiens	82-87
19168722-5	2009	Similar results were obtained for the combined administration of uPA with the alpha(V)beta(3) antagonist Arg-Gly-Asp-d-Phe-Val and Arg-Gly-Asp-Ser, but not for the inactive analog Arg-Gly-Asp-Glu-Ser acetate.	Aspartic Acid	113-116	plasminogen activator, urokinase	Sus scrofa	65-68
19796526-3	2009	METHODS: MBL2 gene polymorphisms in exon 1 (MBL2 54 Gly/Asp, (A/B)), promoter (MBL2 H/L (G-550C), MBL2 Y/X (G-221C)), and 5" UTR region (MBL2 P/Q (C+4T)) were investigated using polymerase chain reaction and restriction fragment length polymorphism in 119 BD patients and 252 healthy controls.	Aspartic Acid	56-59	mannose binding lectin 2	Homo sapiens	9-13
19402527-0	2009	[Effect of isomerization of aspartate-7 on the binding of copper (II) ion by the beta-amyloid peptide].	Aspartic Acid	28-37	amyloid beta precursor protein	Homo sapiens	81-101
19081568-8	2009	Substitution of different amino acids at 374 showed that aspartate in this position was critical; even glutamate at residue 374 increased LDLR degradation.	Aspartic Acid	57-66	low density lipoprotein receptor	Homo sapiens	138-142
19225614-1	2009	A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence.	Aspartic Acid	286-299	integrin subunit alpha V	Homo sapiens	237-261
19091960-7	2009	We mutated three consensus PKC phosphorylation sites (T26, S40, and S499) in hASIC1b to alanine, to prevent phosphorylation, and to glutamic acid or aspartic acid, to mimic phosphorylation.	Aspartic Acid	149-162	acid sensing ion channel subunit 1	Homo sapiens	77-83
19191576-9	2009	p70S6K was primarily cleaved at a noncanonical recognition site, Thr-Pro-Val-Asp, after Asp-393.	Aspartic Acid	77-80	ribosomal protein S6 kinase B1	Homo sapiens	0-6
19135030-2	2009	Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site.	Aspartic Acid	106-109	meprin 1 alpha	Mus musculus	44-52
19135030-2	2009	Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site.	Aspartic Acid	106-109	meprin 1 alpha	Mus musculus	57-69
19135030-2	2009	Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site.	Aspartic Acid	106-109	interleukin 1 beta	Mus musculus	81-89
19038967-2	2009	TPP1 represents the only known mammalian member of the S53 family of serine proteases, a group characterized by a subtilisin-like fold, a Ser-Glu-Asp catalytic triad, and an acidic pH optimum.	Aspartic Acid	146-149	tripeptidyl peptidase 1	Homo sapiens	0-4
18803481-5	2009	To manipulate EC adhesion, migration, and tubulogenesis, the surface of PEGDA hydrogels was micropatterned with a cell adhesive ligand, Arg-Gly-Asp-Ser (RGDS), in desired concentrations and geometries.	Aspartic Acid	144-147	ral guanine nucleotide dissociation stimulator	Homo sapiens	153-157
18986305-5	2009	We demonstrate that Asp(153) is the main determinant of tyrosine sulfation in anionic trypsinogen, as both the natural p.D153H variation and the p.D153N mutation result in a complete loss of trypsinogen sulfation.	Aspartic Acid	20-23	serine protease 2	Homo sapiens	78-97
19088078-3	2009	When PMA2 was expressed in Saccharomyces cerevisiae, mutagenesis of each of these two residues into Asp prevented growth of a yeast strain devoid of its own H(+)-ATPases.	Aspartic Acid	100-103	H(+)-exporting P2-type ATPase PMA2	Saccharomyces cerevisiae S288C	5-9
19199251-5	2009	RESULTS: A missense mutation of GAT>CAT was identified at codon 1441 of the COL1A1 gene from the family, which resulted in the replacement of aspartic acid by histidine (D1441H).	Aspartic Acid	142-155	catalase	Homo sapiens	36-39
19108589-0	2009	Conserved water mediated H-bonding dynamics of inhibitor, cofactor, Asp 364 and Asn 303 in human IMPDH II.	Aspartic Acid	68-71	inosine monophosphate dehydrogenase 2	Homo sapiens	97-105
18995910-5	2009	All 5 insertions, 2 N-glycosylation sites, most of the cysteines, the conserved aspartate, the TM and each of the cytoplasmic regions are essential for TLR8 signaling.	Aspartic Acid	80-89	toll-like receptor 8	Bos taurus	152-156
18854198-8	2009	Hyperalgesia was correlated with CSF aspartate and glutamate levels.	Aspartic Acid	37-46	colony stimulating factor 2	Rattus norvegicus	33-36
18823071-1	2009	A novel assay for the determination of l-asparaginase activity in human plasma is described that is based on the HPLC quantitation of l-aspartic acid produced during enzyme incubation.	Aspartic Acid	134-149	asparaginase and isoaspartyl peptidase 1	Homo sapiens	39-53
18839067-4	2009	We prepared a homology model for GSK-3alpha, and showed that the change from Asp to Glu should not affect maleimide binding significantly.	Aspartic Acid	77-80	glycogen synthase kinase 3 alpha	Homo sapiens	33-43
19199251-5	2009	RESULTS: A missense mutation of GAT>CAT was identified at codon 1441 of the COL1A1 gene from the family, which resulted in the replacement of aspartic acid by histidine (D1441H).	Aspartic Acid	142-155	collagen type I alpha 1 chain	Homo sapiens	76-82
19061898-3	2009	The inhibitor stabilizes the N-terminal domain of NS3p and the substrate-binding site, and correctly aligns catalytic His-Asp residues.	Aspartic Acid	122-125	KRAS proto-oncogene, GTPase	Homo sapiens	50-54
19355988-8	2009	The structures of HDAC8 with bound substrate-like peptide molecule demonstrate the functional role of a conserved aspartate residue located at the rim of the active site in substrate recognition.	Aspartic Acid	114-123	histone deacetylase 8	Homo sapiens	18-23
19028686-10	2009	These studies suggest that cathepsin K interaction with type I collagen is required for 1) the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2) termination of resorption via the creation of autocrine signals originating from type I collagen degradation.	Aspartic Acid	122-125	cathepsin K	Mus musculus	27-38
19141286-2	2009	The structure of the kinase domain of the MAP2K MEK6 with phosphorylation site mimetic aspartic acid mutations (MEK6/DeltaN/DD) has been solved at 2.3 angstroms resolution.	Aspartic Acid	87-100	microtubule associated protein 2	Homo sapiens	42-46
19141286-2	2009	The structure of the kinase domain of the MAP2K MEK6 with phosphorylation site mimetic aspartic acid mutations (MEK6/DeltaN/DD) has been solved at 2.3 angstroms resolution.	Aspartic Acid	87-100	mitogen-activated protein kinase kinase 6	Homo sapiens	48-52
19141286-2	2009	The structure of the kinase domain of the MAP2K MEK6 with phosphorylation site mimetic aspartic acid mutations (MEK6/DeltaN/DD) has been solved at 2.3 angstroms resolution.	Aspartic Acid	87-100	mitogen-activated protein kinase kinase 6	Homo sapiens	112-116
19137435-6	2009	Alanine replacement of aspartic acids 11, 16, and 17 within the full-length p26 prevented TA but did not impair subcellular localization and the symptom expression.	Aspartic Acid	23-37	transmembrane p24 trafficking protein 3	Homo sapiens	76-79
18698130-1	2009	Dentin matrix protein 1 (DMP1) is present in the extracellular matrix (ECM) of dentin and bone as processed NH(2)- and COOH-terminal fragments, resulting from proteolytic cleavage at the NH(2) termini of 4 aspartic acid residues during rat DMP1 processing.	Aspartic Acid	206-219	dentin matrix acidic phosphoprotein 1	Rattus norvegicus	0-23
18698130-1	2009	Dentin matrix protein 1 (DMP1) is present in the extracellular matrix (ECM) of dentin and bone as processed NH(2)- and COOH-terminal fragments, resulting from proteolytic cleavage at the NH(2) termini of 4 aspartic acid residues during rat DMP1 processing.	Aspartic Acid	206-219	dentin matrix acidic phosphoprotein 1	Rattus norvegicus	25-29
18698130-2	2009	One cleavage site residue, Asp(181) (corresponding to Asp(197) of mouse DMP1), and its flanking region are highly conserved across species.	Aspartic Acid	27-30	dentin matrix protein 1	Mus musculus	72-76
18698130-2	2009	One cleavage site residue, Asp(181) (corresponding to Asp(197) of mouse DMP1), and its flanking region are highly conserved across species.	Aspartic Acid	54-57	dentin matrix protein 1	Mus musculus	72-76
18698130-3	2009	We speculate that cleavage at the NH(2) terminus of Asp(197) of mouse DMP1 represents an initial, first-step scission in the whole cascade of proteolytic processing.	Aspartic Acid	52-55	dentin matrix protein 1	Mus musculus	70-74
18698130-4	2009	To test if Asp(197) is critical for initiating the proteolytic processing of mouse DMP1, we substituted Asp(197) with Ala(197) by mutating the corresponding nucleotides of mouse cDNA that encode this amino acid residue.	Aspartic Acid	11-14	dentin matrix protein 1	Mus musculus	83-87
18698130-6	2009	Data from transfection experiments indicated that this single substitution blocked the proteolytic processing of mouse DMP1 in HEK-293 cells, indicating that cleavage at the NH(2) terminus of Asp(197) is essential for exposing other cleavage sites for the conversion of DMP1 to its fragments.	Aspartic Acid	192-195	dentin matrix protein 1	Mus musculus	119-123
18698130-6	2009	Data from transfection experiments indicated that this single substitution blocked the proteolytic processing of mouse DMP1 in HEK-293 cells, indicating that cleavage at the NH(2) terminus of Asp(197) is essential for exposing other cleavage sites for the conversion of DMP1 to its fragments.	Aspartic Acid	192-195	dentin matrix acidic phosphoprotein 1	Homo sapiens	270-274
19601844-3	2009	The structures mediating these interactions include the domain of versatile docking (DVD) responsible for MAP3K-MAP2K-interaction and the common docking (CD)-domain and the ED (glutamate/aspartate)-site of MAPKs together with the various docking (D) motifs in MAP2Ks, MAPK substrates and MAPK-phosphatases.	Aspartic Acid	187-196	mitogen-activated protein kinase 3	Homo sapiens	206-210
18941114-1	2009	Veltuzumab is a humanized anti-CD20 monoclonal antibody with complementarity-determining regions (CDRs) identical to rituximab, except for one residue at the 101st position (Kabat numbering) in CDR3 of the variable heavy chain (V(H)), having aspartic acid (Asp) instead of asparagine (Asn), with framework regions of epratuzumab, a humanized anti-CD22 antibody.	Aspartic Acid	242-255	CDR3	Homo sapiens	194-198
18941114-1	2009	Veltuzumab is a humanized anti-CD20 monoclonal antibody with complementarity-determining regions (CDRs) identical to rituximab, except for one residue at the 101st position (Kabat numbering) in CDR3 of the variable heavy chain (V(H)), having aspartic acid (Asp) instead of asparagine (Asn), with framework regions of epratuzumab, a humanized anti-CD22 antibody.	Aspartic Acid	257-260	CDR3	Homo sapiens	194-198
18987357-2	2009	Using chimeric human-rat alphaIIbbeta3 molecules, we found that this difference in Arg-Gly-Asp-Ser (RGDS) sensitivity was the result of amino acid substitutions at residues 157, 159, and 162 in the W3:4-1 loop and an Asp-His replacement at residue 232 in the W4:4-1 loop of the alphaIIb beta propeller.	Aspartic Acid	91-94	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	100-104
18987357-2	2009	Using chimeric human-rat alphaIIbbeta3 molecules, we found that this difference in Arg-Gly-Asp-Ser (RGDS) sensitivity was the result of amino acid substitutions at residues 157, 159, and 162 in the W3:4-1 loop and an Asp-His replacement at residue 232 in the W4:4-1 loop of the alphaIIb beta propeller.	Aspartic Acid	217-220	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	100-104
18554515-5	2009	These included a T/A SNP, identified in a Holstein Friesian animal, which resulted in a valine to aspartic acid substitution (Val89Asp) in the mature lactoferrin protein.	Aspartic Acid	98-111	lactotransferrin	Bos taurus	150-161
19958195-0	2009	HB Fannin-Lubbock-I with a single GGC&gt;GAC mutation at beta119(GH2)Gly--&gt;Asp in a homozygous Mexican patient.	Aspartic Acid	78-81	growth hormone 2	Homo sapiens	65-68
18845906-6	2009	A novel heterozygous mutation of a 3-bp (GAC) deletion at codon 631 (D631del) of exon 11, resulting in the deletion of an aspartic acid at the locus, was identified in four MEN2A patients and one phenotypically normal family member.	Aspartic Acid	122-135	ret proto-oncogene	Homo sapiens	173-178
19287060-4	2009	The objective of the present study was to determine the presence of genotype frequencies of Glu298--&gt;Asp (G894T) single nucleotide polymorphism in the eNOS gene among south Indian male Tamil speaking population.	Aspartic Acid	104-107	nitric oxide synthase 3	Homo sapiens	154-158
19287060-5	2009	METHODS: Polymerase chain reaction and restriction fragmant analysis was done to detect the presence of Glu298--&gt;Asp (G894T) variant of the eNOS gene in 105 healthy male volunteers.	Aspartic Acid	116-119	nitric oxide synthase 3	Homo sapiens	143-147
19922365-7	2009	Mutation of serine 465 to alanine or aspartic acid, but not the mutation of threonine 5 to alanine, abolished PKC-increased EAAT3 activity.	Aspartic Acid	37-50	solute carrier family 1 member 1	Rattus norvegicus	124-129
20224238-1	2009	In the colony of Sprague-Dawley (SD) strain, we found that there were rats expressing a mutant AQP5, which has a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the 3rd transmembrane domain.	Aspartic Acid	194-197	aquaporin 5	Rattus norvegicus	95-99
19114635-3	2009	The importance of the signature sequence is attested by the fact that a glycine to aspartate mutation (i.e., G551D) in cystic fibrosis transmembrane conductance regulator (CFTR) results in a severe phenotype of cystic fibrosis.	Aspartic Acid	83-92	CF transmembrane conductance regulator	Homo sapiens	119-170
19114635-3	2009	The importance of the signature sequence is attested by the fact that a glycine to aspartate mutation (i.e., G551D) in cystic fibrosis transmembrane conductance regulator (CFTR) results in a severe phenotype of cystic fibrosis.	Aspartic Acid	83-92	CF transmembrane conductance regulator	Homo sapiens	172-176
19915299-3	2009	Sequencing of the KIT DNA revealed a point mutation at codon 816 including a substitution of valine for aspartic acid (D816V).	Aspartic Acid	104-117	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	18-21
19117199-10	2009	Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of a conformation-specific epitope of hCGbeta consists of Arg (94, 95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region.	Aspartic Acid	232-235	chorionic gonadotropin subunit beta 3	Homo sapiens	195-202
19685303-4	2009	The indicator is composed of an engineered firefly luciferase, of which the N- and C-terminal ends are linked with a substrate sequence of caspase-3 (Asp-Glu-Val-Asp).	Aspartic Acid	150-153	caspase 3	Homo sapiens	139-148
18786181-5	2009	In plants cyanide is converted to beta-cyano-L-alanine, which is subsequently detoxified to aspartic acid and ammonia by NIT4.	Aspartic Acid	92-105	nitrilase 4	Arabidopsis thaliana	121-125
18687343-4	2009	Prior work revealed that introduction of aspartic acid at this site strongly reduces GluK2 sensitivity to monovalent cations of different size.	Aspartic Acid	41-54	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	85-90
18819016-9	2009	The Special TRIPLE spectra were pH dependent, and at pH 8, the introduction of aspartate at L170 increased the spin density ratio, rho (L)/rho (M), to 6.1 while an aspartate at the symmetry related position, M199, decreased the ratio to 0.7 compared to the value of 2.1 for wild type.	Aspartic Acid	79-88	rhodopsin	Homo sapiens	131-142
18808456-6	2009	This allowed us to identify a diacidic motif, DIE (Asp-Ile-Glu), at position 4-6 of the N-terminus of ZmPIP2;5, that is essential for ER export.	Aspartic Acid	51-54	aquaporin PIP2-5	Zea mays	102-110
19262692-3	2009	Bestrophins feature a well conserved Asp-rich tract in their COOH terminus (Asp-rich domain), which is homologous to Ca2+-binding motifs in human thrombospondins and in human big-conductance Ca2+- and voltage-gated K+ channels (BK(Ca)).	Aspartic Acid	76-79	carbonic anhydrase 2	Homo sapiens	117-120
19262692-3	2009	Bestrophins feature a well conserved Asp-rich tract in their COOH terminus (Asp-rich domain), which is homologous to Ca2+-binding motifs in human thrombospondins and in human big-conductance Ca2+- and voltage-gated K+ channels (BK(Ca)).	Aspartic Acid	37-40	carbonic anhydrase 2	Homo sapiens	117-120
19262692-3	2009	Bestrophins feature a well conserved Asp-rich tract in their COOH terminus (Asp-rich domain), which is homologous to Ca2+-binding motifs in human thrombospondins and in human big-conductance Ca2+- and voltage-gated K+ channels (BK(Ca)).	Aspartic Acid	37-40	carbonic anhydrase 2	Homo sapiens	191-194
19262692-3	2009	Bestrophins feature a well conserved Asp-rich tract in their COOH terminus (Asp-rich domain), which is homologous to Ca2+-binding motifs in human thrombospondins and in human big-conductance Ca2+- and voltage-gated K+ channels (BK(Ca)).	Aspartic Acid	76-79	carbonic anhydrase 2	Homo sapiens	191-194
19262692-4	2009	Consequently, the Asp-rich domain is also a candidate for Ca2+ binding in bestrophins.	Aspartic Acid	18-21	carbonic anhydrase 2	Homo sapiens	58-61
19262692-6	2009	Molecular dynamics simulations were used to identify Asp and Glu residues binding Ca2+ and to predict the effects of their mutations to alanine.	Aspartic Acid	53-56	carbonic anhydrase 2	Homo sapiens	82-85
19262692-7	2009	We then proceeded to test selected mutations in the Asp-rich domain of the highly homologous mouse bestrophin-2.	Aspartic Acid	52-55	bestrophin 2	Mus musculus	99-111
19689412-2	2009	Among these, the most frequent type presents a lysine residue at position 49 (Lys49), in substitution of the otherwise conserved aspartate (Asp49) of catalytically-active PLA(2)s.	Aspartic Acid	129-138	phospholipase A2 group IIA	Homo sapiens	171-178
19565999-4	2009	The simulation process was guided in the main by cross-linking studies which proposed that Lys-13 of cytochrome c is paired with Asp-158 of COX.	Aspartic Acid	129-132	cytochrome c, somatic	Homo sapiens	101-113
19063607-5	2008	In multidrug resistance protein (MRP) 1, this residue is Asp (D793).	Aspartic Acid	57-60	ATP binding cassette subfamily C member 1	Homo sapiens	3-39
19053766-4	2008	Ac-Trp-[Arg(24),Lys(25),Asp(31),Pro(34),Phe(35)]CGRP(8-37)-NH(2), 5 (K(i) = 0.06 nM) had the highest CGRP(1) receptor affinity.	Aspartic Acid	24-27	calcitonin related polypeptide alpha	Homo sapiens	48-52
19049349-6	2008	Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.	Aspartic Acid	394-397	phosphodiesterase 4A	Homo sapiens	59-63
19049349-6	2008	Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.	Aspartic Acid	394-397	phosphodiesterase 4A	Homo sapiens	119-123
18852012-15	2008	The first NAT crystallographic structure from Salmonella typhimurium identified the mechanism of acetyl transfer via a catalytic triad of Cys, His and Asp residues each essential for activity in all NATs.	Aspartic Acid	151-154	bromodomain containing 2	Homo sapiens	10-13
19013073-4	2008	Compound 33d, which displayed the highest BACE 1 activity (18.33+/-2.80 micromol/L) among these two series, was chosen to study the protein binding pattern and the result showed that it was in close contact with two essential catalytic aspartates (Asp32 and Asp228) of the BACE 1.	Aspartic Acid	236-246	beta-secretase 1	Homo sapiens	42-48
18854175-0	2008	Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation.	Aspartic Acid	37-40	caspase 3	Homo sapiens	6-15
19053259-3	2008	In this report, the role of an anionic cluster (Asp(57), Asp(59), Glu(62), and Asp(65)) in the exodomain of PAR4 is examined for its influence on cleavage and activation of PAR4 on cells in the absence or presence of PAR1.	Aspartic Acid	48-51	F2R like thrombin or trypsin receptor 3	Homo sapiens	108-112
18974096-7	2008	In contrast, phospho-mimic (Ser-62 --&gt; Asp) Bcl-xL exhibited a reduced capacity to bind Bax.	Aspartic Acid	42-45	BCL2 like 1	Homo sapiens	47-53
18974096-7	2008	In contrast, phospho-mimic (Ser-62 --&gt; Asp) Bcl-xL exhibited a reduced capacity to bind Bax.	Aspartic Acid	42-45	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
19053259-3	2008	In this report, the role of an anionic cluster (Asp(57), Asp(59), Glu(62), and Asp(65)) in the exodomain of PAR4 is examined for its influence on cleavage and activation of PAR4 on cells in the absence or presence of PAR1.	Aspartic Acid	57-60	F2R like thrombin or trypsin receptor 3	Homo sapiens	108-112
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Aspartic Acid	234-237	ret proto-oncogene	Homo sapiens	109-112
19053259-3	2008	In this report, the role of an anionic cluster (Asp(57), Asp(59), Glu(62), and Asp(65)) in the exodomain of PAR4 is examined for its influence on cleavage and activation of PAR4 on cells in the absence or presence of PAR1.	Aspartic Acid	57-60	F2R like thrombin or trypsin receptor 3	Homo sapiens	108-112
19053259-7	2008	Individual point mutations at Asp(57), Asp(59), Glu(62), and Asp(65) show that PAR4-D57A is activated by alpha-thrombin with the same EC(50) as PAR4-wt (140 nM) whereas PAR4-D59A is the same as PAR4-AAAA (699 nM).	Aspartic Acid	30-33	F2R like thrombin or trypsin receptor 3	Homo sapiens	79-83
19053259-7	2008	Individual point mutations at Asp(57), Asp(59), Glu(62), and Asp(65) show that PAR4-D57A is activated by alpha-thrombin with the same EC(50) as PAR4-wt (140 nM) whereas PAR4-D59A is the same as PAR4-AAAA (699 nM).	Aspartic Acid	30-33	coagulation factor II, thrombin	Homo sapiens	111-119
19053259-8	2008	Glu(62) and Asp(65) contribute to alpha-thrombin recognition, but to a lesser extent.	Aspartic Acid	12-15	coagulation factor II, thrombin	Homo sapiens	40-48
19053285-4	2008	One of these residues, T106 in HePTP, is either an aspartate or asparagine in nearly every other PTP.	Aspartic Acid	51-60	protein tyrosine phosphatase non-receptor type 7	Homo sapiens	31-36
19053285-4	2008	One of these residues, T106 in HePTP, is either an aspartate or asparagine in nearly every other PTP.	Aspartic Acid	51-60	protein tyrosine phosphatase receptor type U	Homo sapiens	33-36
19053285-8	2008	Strikingly, we were only able to obtain crystals of these transient complexes using a KIM-PTP specific substrate-trapping mutant, in which the KIM-PTP specific residue T106 was mutated to an aspartic acid (T106D).	Aspartic Acid	191-204	protein tyrosine phosphatase receptor type U	Homo sapiens	90-93
19053285-8	2008	Strikingly, we were only able to obtain crystals of these transient complexes using a KIM-PTP specific substrate-trapping mutant, in which the KIM-PTP specific residue T106 was mutated to an aspartic acid (T106D).	Aspartic Acid	191-204	protein tyrosine phosphatase receptor type U	Homo sapiens	147-150
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Aspartic Acid	234-237	GDNF family receptor alpha 1	Homo sapiens	137-148
18820257-4	2008	The result showed that the C-terminal Asp residue of the heavy chains forms an ester bond to Ser(28) beta-carbon of TSG-6 suggesting that this residue plays a role during catalysis.	Aspartic Acid	38-41	TNF alpha induced protein 6	Homo sapiens	116-121
19030549-1	2008	This work reports the synthesis of protected Gly-Arg-Gly-Asp-Ser functionalised hydrogels, which are deprotected (and activated for cell adhesion) by reaction with glutathione-S-transferase.	Aspartic Acid	57-60	glutathione S-transferase kappa 1	Homo sapiens	164-189
18991400-9	2008	Alanine mutations of Lys(484), Leu(552), Asp(591), Ile(602), Lys(616), Asp(620), and Pro(621) compromised affinities for insulin 2-5-fold.	Aspartic Acid	41-44	insulin	Homo sapiens	121-128
18991400-9	2008	Alanine mutations of Lys(484), Leu(552), Asp(591), Ile(602), Lys(616), Asp(620), and Pro(621) compromised affinities for insulin 2-5-fold.	Aspartic Acid	71-74	insulin	Homo sapiens	121-128
19012067-8	2008	Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of hCGbeta epitope consists of Arg (94,95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region.	Aspartic Acid	204-207	chorionic gonadotropin subunit beta 3	Homo sapiens	160-167
19548347-0	2008	A novel 4-oxo-2(E)-nonenal-derived modification to angiotensin II: oxidative decarboxylation of N-terminal aspartic acid.	Aspartic Acid	107-120	angiotensinogen	Homo sapiens	51-65
18952167-4	2008	On the contrary, it has recently also been shown that CH domains can bind other macromolecular systems: two CH domains from separate polypeptides Ncd80, Nuf2 can form a microtubule-binding site, as well as tandem CH domains in the EB1 dimer, while the single C-terminal CH domain of alpha-parvin has been observed to bind to a alpha-helical leucin-aspartate rich motif from paxillin.	Aspartic Acid	348-357	microtubule associated protein RP/EB family member 1	Homo sapiens	231-234
18755685-3	2008	We show that TRPC3 interacts with RACK1 via N-terminal residues Glu-232, Asp-233, Glu-240, and Glu-244.	Aspartic Acid	73-76	transient receptor potential cation channel subfamily C member 3	Homo sapiens	13-18
19108623-5	2008	The 12 amino acid residue of the heavy chain CDR3 is rich in negatively charged aspartic acid (25%) and did not show significant homology to any murine V gene available on the database.	Aspartic Acid	80-93	cerebellar degeneration-related 3	Mus musculus	45-49
18667412-3	2008	Of the 1022 proteins that were identified, 20 were found to be specifically cleaved after Asp in the setup incubated with recombinant caspase-1.	Aspartic Acid	90-93	caspase 1	Homo sapiens	134-143
18667412-6	2008	Consistently recombinant caspase-1 cleaved caspase-7 at the canonical activation sites Asp(23) and Asp(198), and recombinant caspase-7 processed a subset of the identified substrates.	Aspartic Acid	87-90	caspase 1	Homo sapiens	25-34
18667412-6	2008	Consistently recombinant caspase-1 cleaved caspase-7 at the canonical activation sites Asp(23) and Asp(198), and recombinant caspase-7 processed a subset of the identified substrates.	Aspartic Acid	87-90	caspase 7	Homo sapiens	43-52
18667412-6	2008	Consistently recombinant caspase-1 cleaved caspase-7 at the canonical activation sites Asp(23) and Asp(198), and recombinant caspase-7 processed a subset of the identified substrates.	Aspartic Acid	99-102	caspase 1	Homo sapiens	25-34
18667412-6	2008	Consistently recombinant caspase-1 cleaved caspase-7 at the canonical activation sites Asp(23) and Asp(198), and recombinant caspase-7 processed a subset of the identified substrates.	Aspartic Acid	99-102	caspase 7	Homo sapiens	43-52
18758923-3	2008	PGE(1) was attached via a cathepsin K-sensitive linkage to HPMA copolymer-Asp(8) conjugate and was tested to determine if it could promote bone formation.	Aspartic Acid	74-77	cathepsin K	Rattus norvegicus	26-37
18952862-5	2008	Mutational analysis of Arabidopsis (Arabidopsis thaliana) DEG15 revealed that conserved histidine, aspartic acid, and serine residues are essential for the proteolytic activity of this enzyme in vitro.	Aspartic Acid	99-112	protease-like protein	Arabidopsis thaliana	58-63
18806265-9	2008	Molecular modeling and functional analyses of Bcl10 point mutants suggest that residues Asp(80) and Glu(84) of helix 5 of the Bcl10 CARD directly contact MALT1.	Aspartic Acid	88-91	BCL10 immune signaling adaptor	Homo sapiens	46-51
18806265-9	2008	Molecular modeling and functional analyses of Bcl10 point mutants suggest that residues Asp(80) and Glu(84) of helix 5 of the Bcl10 CARD directly contact MALT1.	Aspartic Acid	88-91	BCL10 immune signaling adaptor	Homo sapiens	126-131
18726831-1	2008	An understanding of aminopeptidase A in hypertension is important, given its ability to cleave the N-terminal aspartic acid of potent vasoconstrictor angiotensin II.	Aspartic Acid	110-123	glutamyl aminopeptidase	Rattus norvegicus	20-36
18726831-1	2008	An understanding of aminopeptidase A in hypertension is important, given its ability to cleave the N-terminal aspartic acid of potent vasoconstrictor angiotensin II.	Aspartic Acid	110-123	angiotensinogen	Rattus norvegicus	150-164
18930675-2	2008	A homozygous missense HEXB mutation (p. D459A) was discovered in six patients with a rare juvenile variant: we show that this disrupts a salt bridge between aspartate D459 and arginine 505 at the subunit interface; R505 mutations are reported in late-onset Sandhoff disease.	Aspartic Acid	157-166	hexosaminidase subunit beta	Homo sapiens	22-26
18498105-8	2008	In particular, the catalytic aspartates act as hydrogen bond acceptors for the N-terminal amino group and the Ser2 hydroxyl in plasmepsin, and the side chains of Lys36pro and Tyr9 in pepsinogen.	Aspartic Acid	29-39	jagged canonical Notch ligand 2	Homo sapiens	110-114
18536010-5	2008	Altered glycosylation caused significant conformational changes for most of the key functional regions of the I-like domain of beta1 integrin, including the metal ion-dependent adhesion site that contains a DLSYS motif, and other critical residues for ligand binding (Asn-224, Glu-229, Asp-233, Asp-267, and Asp-295).	Aspartic Acid	286-289	integrin subunit beta 1	Homo sapiens	127-141
18536010-5	2008	Altered glycosylation caused significant conformational changes for most of the key functional regions of the I-like domain of beta1 integrin, including the metal ion-dependent adhesion site that contains a DLSYS motif, and other critical residues for ligand binding (Asn-224, Glu-229, Asp-233, Asp-267, and Asp-295).	Aspartic Acid	295-298	integrin subunit beta 1	Homo sapiens	127-141
18536010-5	2008	Altered glycosylation caused significant conformational changes for most of the key functional regions of the I-like domain of beta1 integrin, including the metal ion-dependent adhesion site that contains a DLSYS motif, and other critical residues for ligand binding (Asn-224, Glu-229, Asp-233, Asp-267, and Asp-295).	Aspartic Acid	295-298	integrin subunit beta 1	Homo sapiens	127-141
18790731-7	2008	Based on these results, we present a LewisX binding mode on MGL1 where the galactose moiety is bound to the primary sugar binding site, including Asp-94, Trp-96, and Asp-118, and the fucose moiety interacts with the secondary sugar binding site, including Ala-89 and Thr-111.	Aspartic Acid	146-149	LLGL scribble cell polarity complex component 1	Homo sapiens	60-64
18790731-7	2008	Based on these results, we present a LewisX binding mode on MGL1 where the galactose moiety is bound to the primary sugar binding site, including Asp-94, Trp-96, and Asp-118, and the fucose moiety interacts with the secondary sugar binding site, including Ala-89 and Thr-111.	Aspartic Acid	166-169	LLGL scribble cell polarity complex component 1	Homo sapiens	60-64
18775986-8	2008	Therefore, proregion Asp and Glu side chains inhibit the RMAD-4 component of full-length proRMAD-4((20-94)), perhaps by a combination of charge-neutralizing and hydrogen-bonding interactions.	Aspartic Acid	21-24	neutrophil defensin 6	Macaca mulatta	57-63
18755685-3	2008	We show that TRPC3 interacts with RACK1 via N-terminal residues Glu-232, Asp-233, Glu-240, and Glu-244.	Aspartic Acid	73-76	receptor for activated C kinase 1	Homo sapiens	34-39
18775457-3	2008	The common feature of this approach is that the presence of the DEVD sequence between GST and EGFP allows for caspase-3-dependent cleavage after the Asp (D) residue, resulting in the elimination of EGFP from the GST:DEVD:EGFP reporter.	Aspartic Acid	149-152	glutathione S-transferase kappa 1	Homo sapiens	86-89
18598240-7	2008	We also showed the involvement of these residues in the strict specificity of APA in the presence of Ca(2+) for N-terminal acidic residues from substrates or inhibitors, since mutagenic replacement of Asp(213) and Asp(218) induced a decrease of the inhibitory potencies of inhibitors homologous with acidic residues.	Aspartic Acid	201-204	glutamyl aminopeptidase	Mus musculus	78-81
18598240-7	2008	We also showed the involvement of these residues in the strict specificity of APA in the presence of Ca(2+) for N-terminal acidic residues from substrates or inhibitors, since mutagenic replacement of Asp(213) and Asp(218) induced a decrease of the inhibitory potencies of inhibitors homologous with acidic residues.	Aspartic Acid	214-217	glutamyl aminopeptidase	Mus musculus	78-81
18598240-8	2008	Finally, this led to the rational design of a new potent APA inhibitor, NI926 (K(i)=70 nM), which allowed us to precisely localize Asp(213) at the entrance and Asp(218) at the bottom of the S1 subsite.	Aspartic Acid	131-134	glutamyl aminopeptidase	Mus musculus	57-60
18598240-8	2008	Finally, this led to the rational design of a new potent APA inhibitor, NI926 (K(i)=70 nM), which allowed us to precisely localize Asp(213) at the entrance and Asp(218) at the bottom of the S1 subsite.	Aspartic Acid	160-163	glutamyl aminopeptidase	Mus musculus	57-60
18995841-3	2008	Here, we report the molecular mechanism by which STIM1 gates TRPC1, which involves interaction between two conserved, negatively charged aspartates in TRPC1((639)DD(640)) with the positively charged STIM1((684)KK(685)) in STIM1 polybasic domain.	Aspartic Acid	137-147	stromal interaction molecule 1	Homo sapiens	49-54
18995841-3	2008	Here, we report the molecular mechanism by which STIM1 gates TRPC1, which involves interaction between two conserved, negatively charged aspartates in TRPC1((639)DD(640)) with the positively charged STIM1((684)KK(685)) in STIM1 polybasic domain.	Aspartic Acid	137-147	transient receptor potential cation channel subfamily C member 1	Homo sapiens	61-66
18995841-3	2008	Here, we report the molecular mechanism by which STIM1 gates TRPC1, which involves interaction between two conserved, negatively charged aspartates in TRPC1((639)DD(640)) with the positively charged STIM1((684)KK(685)) in STIM1 polybasic domain.	Aspartic Acid	137-147	transient receptor potential cation channel subfamily C member 1	Homo sapiens	151-156
18995841-3	2008	Here, we report the molecular mechanism by which STIM1 gates TRPC1, which involves interaction between two conserved, negatively charged aspartates in TRPC1((639)DD(640)) with the positively charged STIM1((684)KK(685)) in STIM1 polybasic domain.	Aspartic Acid	137-147	stromal interaction molecule 1	Homo sapiens	199-204
18995841-3	2008	Here, we report the molecular mechanism by which STIM1 gates TRPC1, which involves interaction between two conserved, negatively charged aspartates in TRPC1((639)DD(640)) with the positively charged STIM1((684)KK(685)) in STIM1 polybasic domain.	Aspartic Acid	137-147	stromal interaction molecule 1	Homo sapiens	199-204
18806265-9	2008	Molecular modeling and functional analyses of Bcl10 point mutants suggest that residues Asp(80) and Glu(84) of helix 5 of the Bcl10 CARD directly contact MALT1.	Aspartic Acid	88-91	MALT1 paracaspase	Homo sapiens	154-159
18775457-3	2008	The common feature of this approach is that the presence of the DEVD sequence between GST and EGFP allows for caspase-3-dependent cleavage after the Asp (D) residue, resulting in the elimination of EGFP from the GST:DEVD:EGFP reporter.	Aspartic Acid	149-152	caspase 3	Homo sapiens	110-119
18775457-3	2008	The common feature of this approach is that the presence of the DEVD sequence between GST and EGFP allows for caspase-3-dependent cleavage after the Asp (D) residue, resulting in the elimination of EGFP from the GST:DEVD:EGFP reporter.	Aspartic Acid	149-152	glutathione S-transferase kappa 1	Homo sapiens	212-215
18987190-1	2008	Aspartoacylase (ASPA) is an oligodendrocyte-restricted enzyme that catalyzes the hydrolysis of neuronally derived N-acetylaspartate (NAA) to acetate and aspartic acid.	Aspartic Acid	153-166	aspartoacylase	Mus musculus	0-14
18987190-1	2008	Aspartoacylase (ASPA) is an oligodendrocyte-restricted enzyme that catalyzes the hydrolysis of neuronally derived N-acetylaspartate (NAA) to acetate and aspartic acid.	Aspartic Acid	153-166	aspartoacylase	Mus musculus	16-20
18822378-5	2008	Mutation of S118 to either Ala or Asp destabilized aromatase, indicating an important structural role for S118.	Aspartic Acid	34-37	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	51-60
18679674-2	2008	It was believed that CphA requires L-aspartic acid (Asp), L-arginine (Arg), ATP, Mg2+, and a primer (low-molecular mass cyanophycin) for cyanophycin synthesis and catalyzes the elongation of a low-molecular mass cyanophycin.	Aspartic Acid	35-50	tlr2170	Thermosynechococcus elongatus BP-1	21-25
18815228-0	2008	Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix.	Aspartic Acid	126-129	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	18-21
18679674-2	2008	It was believed that CphA requires L-aspartic acid (Asp), L-arginine (Arg), ATP, Mg2+, and a primer (low-molecular mass cyanophycin) for cyanophycin synthesis and catalyzes the elongation of a low-molecular mass cyanophycin.	Aspartic Acid	52-55	tlr2170	Thermosynechococcus elongatus BP-1	21-25
18679674-5	2008	The Tlr2170 protein showed strict substrate specificity toward Asp and Arg.	Aspartic Acid	63-66	tlr2170	Thermosynechococcus elongatus BP-1	4-11
18948743-6	2008	Conversely, mutation of S242 to aspartic acid (D), rendered the phosphomimetic HuR(S242D) nuclear under all treatment conditions.	Aspartic Acid	32-45	ELAV like RNA binding protein 1	Homo sapiens	79-82
18718528-9	2008	The loss of phosphorylation of PKB by S396A mutation was rescued by forcing nuclear PDK1 or by conversion of S396 to an aspartic acid.	Aspartic Acid	120-133	protein tyrosine kinase 2 beta	Homo sapiens	31-34
18800361-4	2008	The detection limits were 1.1 nmol/L for dansyl-leucine (Leu) and 2.0 nmol/L for dansyl-aspartic acid (Asp).	Aspartic Acid	103-106	CD8a molecule	Homo sapiens	41-67
18768964-5	2008	We show that Asp(632) substitutions with positively charged residues (D632K and D632R) or a hydrophobic residue (D632V) could completely abolish Env-mediated viral entry, while a protein with a conserved substitution (D632E) retained its activity.	Aspartic Acid	13-16	endogenous retrovirus group K member 20	Homo sapiens	145-148
18799579-5	2008	Using these NSP3 mutants and a deletion mutant unable to associate with eIF4G, we show that the nuclear localization of PABP-C1 not only is dependent on the capacity of NSP3 to interact with eIF4G but also requires the interaction of NSP3 with a specific region in RoXaN, the leucine- and aspartic acid-rich (LD) domain.	Aspartic Acid	289-302	poly(A) binding protein cytoplasmic 1	Homo sapiens	120-127
18799579-5	2008	Using these NSP3 mutants and a deletion mutant unable to associate with eIF4G, we show that the nuclear localization of PABP-C1 not only is dependent on the capacity of NSP3 to interact with eIF4G but also requires the interaction of NSP3 with a specific region in RoXaN, the leucine- and aspartic acid-rich (LD) domain.	Aspartic Acid	289-302	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	191-196
18768471-4	2008	We have introduced the FAD-associated PS1 G384A mutation, which occurs within the highly conserved GXGD motif of PS1 right next to the catalytically critical aspartate residue, into the corresponding GXGD motif of the signal peptide peptidase-like 2b (SPPL2b).	Aspartic Acid	158-167	taste 2 receptor member 62 pseudogene	Homo sapiens	38-41
18728004-7	2008	Incubation with a human deubiquitinating enzyme (USP-2 core) converted the p110:p107 PEPC heterotetramer into a p107 homotetramer while significantly reducing the enzyme"s K(m)(PEP) and sensitivity to allosteric activators (hexose-Ps, glycerol-3-P) and inhibitors (malate, aspartate).	Aspartic Acid	273-282	RB transcriptional corepressor like 1	Homo sapiens	80-84
18728004-7	2008	Incubation with a human deubiquitinating enzyme (USP-2 core) converted the p110:p107 PEPC heterotetramer into a p107 homotetramer while significantly reducing the enzyme"s K(m)(PEP) and sensitivity to allosteric activators (hexose-Ps, glycerol-3-P) and inhibitors (malate, aspartate).	Aspartic Acid	273-282	phosphoenolpyruvate carboxykinase 1	Homo sapiens	85-89
18728004-7	2008	Incubation with a human deubiquitinating enzyme (USP-2 core) converted the p110:p107 PEPC heterotetramer into a p107 homotetramer while significantly reducing the enzyme"s K(m)(PEP) and sensitivity to allosteric activators (hexose-Ps, glycerol-3-P) and inhibitors (malate, aspartate).	Aspartic Acid	273-282	RB transcriptional corepressor like 1	Homo sapiens	112-116
18728004-7	2008	Incubation with a human deubiquitinating enzyme (USP-2 core) converted the p110:p107 PEPC heterotetramer into a p107 homotetramer while significantly reducing the enzyme"s K(m)(PEP) and sensitivity to allosteric activators (hexose-Ps, glycerol-3-P) and inhibitors (malate, aspartate).	Aspartic Acid	273-282	progestagen associated endometrial protein	Homo sapiens	85-88
18728004-7	2008	Incubation with a human deubiquitinating enzyme (USP-2 core) converted the p110:p107 PEPC heterotetramer into a p107 homotetramer while significantly reducing the enzyme"s K(m)(PEP) and sensitivity to allosteric activators (hexose-Ps, glycerol-3-P) and inhibitors (malate, aspartate).	Aspartic Acid	273-282	ubiquitin specific peptidase 2	Homo sapiens	49-54
18728004-7	2008	Incubation with a human deubiquitinating enzyme (USP-2 core) converted the p110:p107 PEPC heterotetramer into a p107 homotetramer while significantly reducing the enzyme"s K(m)(PEP) and sensitivity to allosteric activators (hexose-Ps, glycerol-3-P) and inhibitors (malate, aspartate).	Aspartic Acid	273-282	spliceosome associated factor 3, U4/U6 recycling protein	Homo sapiens	75-79
18768471-4	2008	We have introduced the FAD-associated PS1 G384A mutation, which occurs within the highly conserved GXGD motif of PS1 right next to the catalytically critical aspartate residue, into the corresponding GXGD motif of the signal peptide peptidase-like 2b (SPPL2b).	Aspartic Acid	158-167	taste 2 receptor member 62 pseudogene	Homo sapiens	113-116
18768471-4	2008	We have introduced the FAD-associated PS1 G384A mutation, which occurs within the highly conserved GXGD motif of PS1 right next to the catalytically critical aspartate residue, into the corresponding GXGD motif of the signal peptide peptidase-like 2b (SPPL2b).	Aspartic Acid	158-167	signal peptide peptidase like 2B	Homo sapiens	218-250
18713736-3	2008	GPIHBP1 contains an amino-terminal acidic domain (amino acids 24-48) that is enriched in aspartate and glutamate residues, and we previously speculated that this domain might be important in binding ligands.	Aspartic Acid	89-98	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1	Cricetulus griseus	0-7
18790019-8	2008	The data obtained show that Abeta(1-40) peptide decreased astroglial glutamate uptake capacity in a non-competitive mode of inhibition, assessed in terms of tritium radiolabeled d-aspartate (d-[(3)H]aspartate) transport.	Aspartic Acid	180-189	amyloid beta precursor protein	Rattus norvegicus	28-33
18693254-1	2008	The p57/coronin-1 protein is a member of the coronin family of actin-binding proteins, which are characterized by the presence of WD (tryptophan/aspartic acid) repeats and a coiled-coil motif in the molecule.	Aspartic Acid	145-158	coronin 1A	Homo sapiens	4-7
18693254-1	2008	The p57/coronin-1 protein is a member of the coronin family of actin-binding proteins, which are characterized by the presence of WD (tryptophan/aspartic acid) repeats and a coiled-coil motif in the molecule.	Aspartic Acid	145-158	coronin 1A	Homo sapiens	8-17
18811140-2	2008	An X-ray cocrystal structure with BACE-1 revealed a novel mode of binding whereby the inhibitor interacts with the catalytic aspartates via bridging water molecules.	Aspartic Acid	125-135	beta-secretase 1	Homo sapiens	34-40
18687688-9	2008	These data taken together suggest that Glu-960, Gln-981, Asp-987, and Glu-1022 residues are engaged in determining divalent cationic permeation properties of the TRPM2 channel.	Aspartic Acid	57-60	transient receptor potential cation channel subfamily M member 2	Homo sapiens	162-167
18678877-7	2008	The NMDGT motif on the partially unwound part of the transmembrane helix TM7 and the residues Asp-390 and Asp-394 on TM8 are also distinguished by their important role in substrate binding and close interaction with mediating water molecules and/or sodium ions.	Aspartic Acid	94-97	tetraspanin 16	Homo sapiens	117-120
18678877-7	2008	The NMDGT motif on the partially unwound part of the transmembrane helix TM7 and the residues Asp-390 and Asp-394 on TM8 are also distinguished by their important role in substrate binding and close interaction with mediating water molecules and/or sodium ions.	Aspartic Acid	106-109	tetraspanin 16	Homo sapiens	117-120
18678877-8	2008	The simulations reveal a Na+ binding site comprised in part of Leu-303 on TM7 and Asp-405 on TM8 and support a role for sodium ions in stabilizing substrate-bound conformers.	Aspartic Acid	82-85	tetraspanin 16	Homo sapiens	93-96
18564064-7	2008	Exposure of MCs to RGD (Arg-Gly-Asp) peptide led to abrogation of the anti-apoptotic effect of uPA, which implies involvement of integrins in this process.	Aspartic Acid	32-35	plasminogen activator, urokinase	Homo sapiens	95-98
18697738-8	2008	In addition, in BCH plus glutamine-stimulated PC knockdown cells, pyruvate plus lactate was increased, whereas citrate was severely decreased, and malate and aspartate were slightly decreased.	Aspartic Acid	158-167	NK2 homeobox 1	Homo sapiens	16-19
18697738-8	2008	In addition, in BCH plus glutamine-stimulated PC knockdown cells, pyruvate plus lactate was increased, whereas citrate was severely decreased, and malate and aspartate were slightly decreased.	Aspartic Acid	158-167	pyruvate carboxylase	Homo sapiens	46-48
18669635-4	2008	Rodent embryonic fibroblasts adhered to PF1 and deletion fragments, and, when cells were plated on fibrillin-1 or fibronectin Arg-Gly-Asp cell-binding fragments, cells showed heparin-dependent spreading and focal contact formation in response to soluble PF1.	Aspartic Acid	134-137	fibronectin 1	Homo sapiens	114-125
18694848-4	2008	Both SMS1 and SMS2 contain two histidines and one aspartic acid which are evolutionary conserved within the lipid phosphate phosphatase superfamily.	Aspartic Acid	50-63	sphingomyelin synthase 1	Homo sapiens	5-9
18662981-7	2008	Fine structure mapping identified several Lys and Arg residues in this region that form salt bridges with Asp and Glu residues in NEIL1.	Aspartic Acid	106-109	nei like DNA glycosylase 1	Homo sapiens	130-135
18694848-4	2008	Both SMS1 and SMS2 contain two histidines and one aspartic acid which are evolutionary conserved within the lipid phosphate phosphatase superfamily.	Aspartic Acid	50-63	sphingomyelin synthase 2	Homo sapiens	14-18
18573309-6	2008	From a comparison of total energy of these three mutant proteins, we identified that the major mutation is from Aspartic acid to Tyrosine at the residue position of 84 of p16INK4A.	Aspartic Acid	112-125	cyclin dependent kinase inhibitor 2A	Homo sapiens	171-179
18599641-7	2008	The novel distorted six-coordinated (3N3O) geometry around copper in the Abeta-Cu(2+) complexes include three histidines: glutamic, or/and aspartic acid, and axial water.	Aspartic Acid	139-152	amyloid beta precursor protein	Homo sapiens	73-78
18615592-1	2008	The interaction between the arginine glycine and aspartic acid motif (RGD) of integrin ligands such as vitronectin and the integrin receptor alphaVbeta3 in mediating cell attachment has been well described.	Aspartic Acid	49-62	vitronectin	Homo sapiens	103-114
18597632-2	2008	An acidic, serine- and aspartic acid-rich motif (ASARM) is located in the C terminus of MEPE and other mineralized tissue matrix proteins.	Aspartic Acid	23-36	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	Mus musculus	88-92
18800818-3	2008	However, when the peptide Arg-Gly-Asp (RGD) was introduced into ES-2, the modified ES-2 showed significant antitumor results in animal models.	Aspartic Acid	34-37	ess-2 splicing factor homolog	Homo sapiens	64-68
18800818-3	2008	However, when the peptide Arg-Gly-Asp (RGD) was introduced into ES-2, the modified ES-2 showed significant antitumor results in animal models.	Aspartic Acid	34-37	ess-2 splicing factor homolog	Homo sapiens	83-87
18616948-6	2008	Only three anionic residues in the propeptide, Glu(15), Asp(20) and Glu(23), were modestly important for interactions with HNP1.	Aspartic Acid	56-59	HNP1	Homo sapiens	123-127
18794864-3	2008	Using an interactive computational-experimental approach, we show that sodium sensitivity of Kir channels involves the side chains of an aspartate and a histidine located across from each other in a crucial loop in the cytosolic domain, as well as the backbone carbonyls of two more residues and a water molecule.	Aspartic Acid	137-146	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	93-96
18434216-1	2008	OBJECTIVE: An association between osteoarthritis (OA) and functional polymorphisms in the aspartic acid (d) repeat of the asporin (ASPN) gene was reported in Japanese and Han Chinese populations.	Aspartic Acid	90-103	asporin	Homo sapiens	122-129
18434216-1	2008	OBJECTIVE: An association between osteoarthritis (OA) and functional polymorphisms in the aspartic acid (d) repeat of the asporin (ASPN) gene was reported in Japanese and Han Chinese populations.	Aspartic Acid	90-103	asporin	Homo sapiens	131-135
18721670-0	2008	Neurotensin modulation of acetylcholine, GABA, and aspartate release from rat prefrontal cortex studied in vivo with microdialysis.	Aspartic Acid	51-60	neurotensin	Rattus norvegicus	0-11
18721670-2	2008	Neurotensin (0.2 and 1 microM) administered locally in the PFC produced a concentration-dependent increase in the extracellular levels of ACh, GABA, and Asp, but not of Glu or taurine.	Aspartic Acid	153-156	neurotensin	Rattus norvegicus	0-11
18508040-17	2008	According to the putative water-activation mechanism of G117H BChE, a new histidine/aspartate dyad was introduced into the active center of human AChE at the optimum location for hydrolysis of the OP adduct.	Aspartic Acid	84-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
18652897-2	2008	The FRET results confirmed by pull-down immunoprecipitation indicated "gain-of-interaction" of the G93A-hSOD1 mutant with cytosolic malate dehydrogenase (cytMDH)-a key enzyme in the malate-aspartate shuttle which is vital to neurons.	Aspartic Acid	189-198	superoxide dismutase 1	Homo sapiens	104-109
18652897-2	2008	The FRET results confirmed by pull-down immunoprecipitation indicated "gain-of-interaction" of the G93A-hSOD1 mutant with cytosolic malate dehydrogenase (cytMDH)-a key enzyme in the malate-aspartate shuttle which is vital to neurons.	Aspartic Acid	189-198	malate dehydrogenase 1	Homo sapiens	122-152
18652897-2	2008	The FRET results confirmed by pull-down immunoprecipitation indicated "gain-of-interaction" of the G93A-hSOD1 mutant with cytosolic malate dehydrogenase (cytMDH)-a key enzyme in the malate-aspartate shuttle which is vital to neurons.	Aspartic Acid	189-198	malate dehydrogenase 1	Homo sapiens	154-160
18652897-4	2008	Consistent with inhibition of the malate-aspartate shuttle, G93A-hSOD1 had lower malate and higher lactate levels compared to non-induced or Wild-Type-hSOD1 expressing cells.	Aspartic Acid	41-50	superoxide dismutase 1	Homo sapiens	65-70
18721670-6	2008	A high-affinity selective neurotensin receptor (NTR1) antagonist SR 48692 (0.5 microM) perfused locally blocked neurotensin (1 microM)-evoked ACh, GABA, and Asp release.	Aspartic Acid	157-160	neurotensin	Rattus norvegicus	26-37
18721670-6	2008	A high-affinity selective neurotensin receptor (NTR1) antagonist SR 48692 (0.5 microM) perfused locally blocked neurotensin (1 microM)-evoked ACh, GABA, and Asp release.	Aspartic Acid	157-160	neurotensin receptor 1	Rattus norvegicus	48-52
18721670-6	2008	A high-affinity selective neurotensin receptor (NTR1) antagonist SR 48692 (0.5 microM) perfused locally blocked neurotensin (1 microM)-evoked ACh, GABA, and Asp release.	Aspartic Acid	157-160	neurotensin	Rattus norvegicus	112-123
18721670-7	2008	Local infusion of the sodium channel blocker tetrodotoxin (TTX) (1 microM) decreased the release of ACh, had no significant effect on GABA or Asp release, and prevented the 1 microM neurotensin-induced increase in ACh, GABA, and Asp output.	Aspartic Acid	229-232	neurotensin	Rattus norvegicus	182-193
18650446-5	2008	Mode 1 expression results from a single amino acid change at residue hbeta1 Asp-37.	Aspartic Acid	76-79	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	69-75
18658136-6	2008	The open conformation in PDK4 shows partially ordered C-terminal cross-tails, in which the conserved DW (Asp(394)-Trp(395)) motif from one subunit anchors to the N-terminal domain of the other subunit.	Aspartic Acid	105-108	pyruvate dehydrogenase kinase 4	Homo sapiens	25-29
18702519-5	2008	We previously reported the serendipitous creation of a protein, His15Asp histidine-containing protein (HPr), which undergoes phosphorylation-catalyzed formation of a succinimide whose hydrolysis is seemingly exclusive for aspartate formation.	Aspartic Acid	222-231	haptoglobin-related protein	Homo sapiens	103-106
18702519-6	2008	Here, through the high-resolution structure of postsuccinimide His15Asp HPr, we confirm the absence of isoaspartate residues and propose mechanisms for phosphorylation-catalyzed succinimide formation and its directed hydrolysis to aspartate.	Aspartic Acid	106-115	haptoglobin-related protein	Homo sapiens	72-75
18768683-6	2008	Of the 23 members of the aspartate-histidine-histidine-cysteine (DHHC) domain containing proteins, DHHC-7 most strongly stimulated palmitoylation of NCAM, and enzyme activity was enhanced by FGF2.	Aspartic Acid	25-34	zinc finger DHHC-type palmitoyltransferase 7	Homo sapiens	99-105
18768683-6	2008	Of the 23 members of the aspartate-histidine-histidine-cysteine (DHHC) domain containing proteins, DHHC-7 most strongly stimulated palmitoylation of NCAM, and enzyme activity was enhanced by FGF2.	Aspartic Acid	25-34	neural cell adhesion molecule 1	Homo sapiens	149-153
18768683-6	2008	Of the 23 members of the aspartate-histidine-histidine-cysteine (DHHC) domain containing proteins, DHHC-7 most strongly stimulated palmitoylation of NCAM, and enzyme activity was enhanced by FGF2.	Aspartic Acid	25-34	fibroblast growth factor 2	Homo sapiens	191-195
18714034-0	2008	Production of C5a by ASP, a serine protease released from Aeromonas sobria.	Aspartic Acid	21-24	complement C5a receptor 1	Homo sapiens	14-17
18703838-2	2008	A zebrafish homolog of the human Plk1 (hPlk1) kinase domain (KD) was identified that can be expressed in large quantities in bacteria and crystallizes readily, whether in a wild-type form or as a variant containing the activating Thr196--&gt;Asp substitution, in one space group and under similar conditions both in the absence and presence of active-site compounds.	Aspartic Acid	242-245	polo like kinase 1	Homo sapiens	33-37
18703838-2	2008	A zebrafish homolog of the human Plk1 (hPlk1) kinase domain (KD) was identified that can be expressed in large quantities in bacteria and crystallizes readily, whether in a wild-type form or as a variant containing the activating Thr196--&gt;Asp substitution, in one space group and under similar conditions both in the absence and presence of active-site compounds.	Aspartic Acid	242-245	polo like kinase 1	Homo sapiens	39-44
17922186-6	2008	For homozygous carriers of the Glu allele in APEX1, a significant protective effect was found when compared to Asp/Asp carriers (odds ratio (OR) = 0.60, 95% confidence interval (CI) = 0.38-0.94).	Aspartic Acid	111-114	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	45-50
17922186-6	2008	For homozygous carriers of the Glu allele in APEX1, a significant protective effect was found when compared to Asp/Asp carriers (odds ratio (OR) = 0.60, 95% confidence interval (CI) = 0.38-0.94).	Aspartic Acid	115-118	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	45-50
18502798-2	2008	Hydrolysis by ADAMTS13 of a VWF analog (Asp(1596)-Arg(1668) peptide, fluorescence energy transfer substrate [FRETS]-VWF73) was investigated by a fluorescence quenching method (FRETS method) from 15 degrees C to 45 degrees C and pH values from 4.5 to 10.5.	Aspartic Acid	40-43	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	14-22
18502798-2	2008	Hydrolysis by ADAMTS13 of a VWF analog (Asp(1596)-Arg(1668) peptide, fluorescence energy transfer substrate [FRETS]-VWF73) was investigated by a fluorescence quenching method (FRETS method) from 15 degrees C to 45 degrees C and pH values from 4.5 to 10.5.	Aspartic Acid	40-43	von Willebrand factor	Homo sapiens	28-31
18502798-7	2008	Asp(1653), Glu(1655), Glu(1660), Asp(1663), together with the hydrophilic side chain of Thr(1656) were shown to form a "hot spot" in the VWF A2 sequence, which drives the molecular recognition and allosteric regulation of binding to ADAMTS13.	Aspartic Acid	0-3	von Willebrand factor	Homo sapiens	137-140
18502798-7	2008	Asp(1653), Glu(1655), Glu(1660), Asp(1663), together with the hydrophilic side chain of Thr(1656) were shown to form a "hot spot" in the VWF A2 sequence, which drives the molecular recognition and allosteric regulation of binding to ADAMTS13.	Aspartic Acid	0-3	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	233-241
18502798-7	2008	Asp(1653), Glu(1655), Glu(1660), Asp(1663), together with the hydrophilic side chain of Thr(1656) were shown to form a "hot spot" in the VWF A2 sequence, which drives the molecular recognition and allosteric regulation of binding to ADAMTS13.	Aspartic Acid	33-36	von Willebrand factor	Homo sapiens	137-140
18524873-1	2008	Typical CYP2D6 substrates generally contain a basic nitrogen atom that interacts with Asp(301) and/or Glu(216) and an aromatic moiety adjacent to the site of metabolism.	Aspartic Acid	86-89	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	8-14
18714034-0	2008	Production of C5a by ASP, a serine protease released from Aeromonas sobria.	Aspartic Acid	21-24	coagulation factor II, thrombin	Homo sapiens	28-43
18714034-5	2008	C5 incubated with enzymatically active ASP induced neutrophil migration in a dose-dependent manner from an ASP concentration of 3 nM and in an incubation time-dependent manner in as little as 7 min, with neutrophil accumulation in guinea pigs at intradermal injection sites and neutrophil superoxide release.	Aspartic Acid	39-42	complement C5	Cavia porcellus	0-2
18714034-5	2008	C5 incubated with enzymatically active ASP induced neutrophil migration in a dose-dependent manner from an ASP concentration of 3 nM and in an incubation time-dependent manner in as little as 7 min, with neutrophil accumulation in guinea pigs at intradermal injection sites and neutrophil superoxide release.	Aspartic Acid	107-110	complement C5	Cavia porcellus	0-2
18714034-8	2008	Together with these C5a-like activities, ASP cleaved C5 to release only one C5a Ag, the m.w.	Aspartic Acid	41-44	complement C5a receptor 1	Homo sapiens	76-79
18714034-10	2008	Immunoblotting using an anti-C5a Ab revealed generation of a C5a-like fragment from human plasma incubated with ASP.	Aspartic Acid	112-115	complement C5a receptor 1	Homo sapiens	29-32
18714034-10	2008	Immunoblotting using an anti-C5a Ab revealed generation of a C5a-like fragment from human plasma incubated with ASP.	Aspartic Acid	112-115	complement C5a receptor 1	Homo sapiens	61-64
18478542-10	2008	Replacement of this tyrosine together with Y1176 with either aspartate or phenylalanine changes ezrin binding and alters colocalization with ezrin in ND7 cells.	Aspartic Acid	61-70	ezrin	Homo sapiens	96-101
18478542-10	2008	Replacement of this tyrosine together with Y1176 with either aspartate or phenylalanine changes ezrin binding and alters colocalization with ezrin in ND7 cells.	Aspartic Acid	61-70	ezrin	Homo sapiens	141-146
18714034-11	2008	These results suggest that ASP-elicited neutrophil migration and vascular leakage via C5a production from C5 could occur in vivo, which was supported by that ASP did not affect functions of C5a and neutrophil C5a receptor.	Aspartic Acid	27-30	complement C5a receptor 1	Homo sapiens	86-89
18714034-12	2008	Through C5a generation, ASP could be associated with the induction of pus and edema caused by infection with this bacterium.	Aspartic Acid	24-27	complement C5a receptor 1	Homo sapiens	8-11
18716162-8	2008	Only the specific aspartate-rich blend of SI and alpha-lactalbumin significantly improved the postprandial Glu response.	Aspartic Acid	18-27	lactalbumin, alpha	Rattus norvegicus	49-66
18785139-1	2008	A CE-LIF detection method has been developed to identify and quantitate six amino acid neurotransmitters including glutamic acid, aspartic acid, gamma-aminobutyric acid, glycine, taurine, and glutamine.	Aspartic Acid	130-143	LIF interleukin 6 family cytokine	Homo sapiens	5-8
18695252-4	2008	RNA interference of sialin expression decreased exocytosis of aspartate and glutamate in pinealocytes.	Aspartic Acid	62-71	solute carrier family 17 member 5	Homo sapiens	20-26
18579593-7	2008	Mutagenesis and molecular modeling define a contact surface for STAT2 association that includes aspartic acid residue 248 as critical for STAT2 interference and IFN antiviral immune suppression.	Aspartic Acid	96-109	signal transducer and activator of transcription 2	Homo sapiens	64-69
18579593-7	2008	Mutagenesis and molecular modeling define a contact surface for STAT2 association that includes aspartic acid residue 248 as critical for STAT2 interference and IFN antiviral immune suppression.	Aspartic Acid	96-109	signal transducer and activator of transcription 2	Homo sapiens	138-143
18579593-7	2008	Mutagenesis and molecular modeling define a contact surface for STAT2 association that includes aspartic acid residue 248 as critical for STAT2 interference and IFN antiviral immune suppression.	Aspartic Acid	96-109	interferon alpha 1	Homo sapiens	161-164
18698233-2	2008	Two relatively common variants of the TLR4 gene are present, resulting in changes from aspartic acid (D) to glycine (G) at residue 299 and from threonine (T) to isoleucine (I) at residue 399, respectively.	Aspartic Acid	87-100	toll like receptor 4	Homo sapiens	38-42
18586680-4	2008	The caspase-3 cleavage site of O-GlcNAcase, mapped by Edman sequencing, is a noncanonical recognition site that occurs after Asp-413 of the SVVD sequence in human O-GlcNAcase.	Aspartic Acid	125-128	caspase 3	Homo sapiens	4-13
18586680-4	2008	The caspase-3 cleavage site of O-GlcNAcase, mapped by Edman sequencing, is a noncanonical recognition site that occurs after Asp-413 of the SVVD sequence in human O-GlcNAcase.	Aspartic Acid	125-128	O-GlcNAcase	Homo sapiens	31-42
18586680-4	2008	The caspase-3 cleavage site of O-GlcNAcase, mapped by Edman sequencing, is a noncanonical recognition site that occurs after Asp-413 of the SVVD sequence in human O-GlcNAcase.	Aspartic Acid	125-128	O-GlcNAcase	Homo sapiens	163-174
18562697-5	2008	A mutation in aspartate-220, which is necessary for putative aspartyl-protease function, abolished the rescue of pds1-128 cells but not homodimerization.	Aspartic Acid	14-23	aspartyl protease	Saccharomyces cerevisiae S288C	61-78
18562638-4	2008	We determined its solution structure, and a structural comparison with the dimeric SAV1 WW2 suggested that an Asp residue is crucial for the inhibition of the dimerization.	Aspartic Acid	110-113	salvador family WW domain containing protein 1	Homo sapiens	83-87
18562638-9	2008	A thermal denaturation study revealed that the dimerized MAGI1 WW2 with the Asp-to-Ser mutation gained apparent stability in a protein concentration-dependent manner.	Aspartic Acid	76-79	membrane associated guanylate kinase, WW and PDZ domain containing 1	Homo sapiens	57-62
18769712-4	2008	Here we report that one of those mutants is caused by a missense mutation in a gene encoding the previously uncharacterized protein WDR55 carrying the tryptophan-aspartate-repeat motif.	Aspartic Acid	162-171	WD repeat domain 55	Mus musculus	132-137
18695252-5	2008	Proteoliposomes containing purified sialin actively accumulated aspartate and glutamate to a similar extent when inside positive membrane potential is imposed as the driving force.	Aspartic Acid	64-73	solute carrier family 17 member 5	Homo sapiens	36-42
18695252-6	2008	Sialin carrying a mutation found in people suffering from Salla disease (R39C) was completely devoid of aspartate and glutamate transport activity, although it retained appreciable H(+)/sialic acid cotransport activity.	Aspartic Acid	104-113	solute carrier family 17 member 5	Homo sapiens	0-6
18670082-1	2008	Based on our previous molecular modeling and radioligand binding study, we have demonstrated that aspartic acid of 104 in transmembrane helix (TMH) II of beta(1)-adrenergic receptor (beta(1)-AR) is important for functional characteristics of these receptors.	Aspartic Acid	98-111	adrenoceptor beta 1	Homo sapiens	154-193
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Aspartic Acid	8-11	prepronociceptin	Homo sapiens	51-56
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Aspartic Acid	8-11	prepronociceptin	Homo sapiens	214-224
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Aspartic Acid	8-11	prepronociceptin	Homo sapiens	225-236
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Aspartic Acid	8-11	prepronociceptin	Homo sapiens	246-249
18572269-7	2008	The rat mast cell line RBL-2H3 were most efficiently transduced with a fiber-mutant Ad5 vector containing the Arg-Gly-Asp (RGD) peptide in the HI loop (Ad-RGD) of the fiber knob.	Aspartic Acid	118-121	Alzheimer disease, familial, type 5	Homo sapiens	84-87
18684943-3	2008	In this study, we report that in bacterial artificial chromosome-transgenic mice, in which the aspartate residue upstream of the initial self-processing site in caspase-8 (D387) was replaced by alanine, induction of cell death by Fas is compromised.	Aspartic Acid	95-104	caspase 8	Mus musculus	161-170
18613815-5	2008	PC from most organisms is a tetrameric protein that is allosterically regulated by acetyl-CoA and aspartate.	Aspartic Acid	98-107	pyruvate carboxylase	Homo sapiens	0-2
18670082-2	2008	We have also showed that mutation of negatively charged aspartic acid to neutral charged alanine exhibited constitutive activity of beta(1)-AR.	Aspartic Acid	56-69	adrenoceptor beta 1	Homo sapiens	132-142
18670082-3	2008	However, the mutation of negatively charged aspartic acid to positively charged lysine is still remained to be examined, which is very important to know for fully understanding the characteristics of beta(1)-AR.	Aspartic Acid	44-57	adrenoceptor beta 1	Homo sapiens	200-210
18979630-11	2008	While cathepsin B is more effective than BACE-1 in processing the Asp-containing peptide derivatives, only cathepsin B can cleave the isoAsp-containing peptides, which occurs with high catalytic efficiency.	Aspartic Acid	66-69	cathepsin B	Homo sapiens	6-17
18979630-11	2008	While cathepsin B is more effective than BACE-1 in processing the Asp-containing peptide derivatives, only cathepsin B can cleave the isoAsp-containing peptides, which occurs with high catalytic efficiency.	Aspartic Acid	66-69	beta-secretase 1	Homo sapiens	41-47
18670082-4	2008	At the present study, we mutated aspartic acid to lysine (Asp104Lys) residue in human beta(1)-AR.	Aspartic Acid	33-46	adrenoceptor beta 1	Homo sapiens	86-96
18670082-10	2008	Thus, we may suggest that mutation of negatively charged aspartic acid to positively charged lysine as well as neutral charged alanine may help to understand the mechanism of the activation or inactivation of beta(1)-AR by its conformational changes and this finding would be helpful for clarifying the functional responses mediated by beta(1)-AR.	Aspartic Acid	57-70	adrenoceptor beta 1	Homo sapiens	209-219
18670082-10	2008	Thus, we may suggest that mutation of negatively charged aspartic acid to positively charged lysine as well as neutral charged alanine may help to understand the mechanism of the activation or inactivation of beta(1)-AR by its conformational changes and this finding would be helpful for clarifying the functional responses mediated by beta(1)-AR.	Aspartic Acid	57-70	adrenoceptor beta 1	Homo sapiens	336-346
18331758-3	2008	To investigate these suggestions, we have used density functional theory to study the structure, spectra, and reduction potential of 25 models of myeloperoxidase in the reduced (Fe(II)) and oxidized (Fe(III)) states, as well as in the compound I (formally Fe(V)O) and II (Fe(IV)O or Fe(IV)OH) states, using appropriate models of the linkages to the Asp, Glu, and Met residues (including the back-bone connection between Glu-242 and Met-243) in varying combinations.	Aspartic Acid	349-352	myeloperoxidase	Homo sapiens	146-161
18617397-2	2008	The compounds exhibit excellent physiochemical properties and a novel binding mode, whereby a bridging interaction via a water molecule with Asp 86 of CDK2, leads to selectivity for the CDK family of enzymes over other kinases.	Aspartic Acid	141-144	cyclin-dependent kinase 2	Mus musculus	151-155
18636161-6	2008	However, expression of the deamidated mutant of Bcl-xL, in which aspartic acid was substituted for both arginine 52 and 66 (N52,66D-Bcl-xL), exhibited high sensitivity for the induction of apoptosis.	Aspartic Acid	65-78	BCL2 like 1	Homo sapiens	48-54
18645195-7	2008	In particular, MD free-energy calculation using PPCs accurately reproduced the experimental value of pK(a) shift for ionizable residue Asp(26) buried inside thioredoxin, whereas previous calculations using standard force fields overestimated pK(a) shift by twice as much.	Aspartic Acid	135-138	thioredoxin	Homo sapiens	157-168
18505429-10	2008	This result suggested that aspartic acid at position 136 may affect NKG2D binding, leading to different degrees of immune cell activation.	Aspartic Acid	27-40	killer cell lectin like receptor K1	Homo sapiens	68-73
18539273-4	2008	In these conditions, MSCs showed increased transcription and expression of the high-affinity glutamate transporter GLT-1 and functional studies revealed increased aspartate uptake activity.	Aspartic Acid	163-172	solute carrier family 1 member 2	Rattus norvegicus	115-120
18480028-3	2008	Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues.	Aspartic Acid	221-224	acetyl-CoA acetyltransferase 1	Homo sapiens	8-12
18756100-4	2008	Unexpectedly, mutant H-16 (Gly-Leu-Val-Tyr) showed almost identical hydrolyzing and transglycosylation activities to wild type, whereas K-33 (Ser-Gly-Asp-Glu) showed an extremely low transglycosylation activity.	Aspartic Acid	150-153	H1.6 linker histone, cluster member	Homo sapiens	21-25
18480028-3	2008	Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues.	Aspartic Acid	221-224	fatty acid synthase	Homo sapiens	126-145
18480028-3	2008	Because ACAT enzymes have an intrinsic thioesterase activity, we hypothesized that by analogy with the thioesterase domain of fatty acid synthase, the active site of ACAT enzymes may comprise a catalytic triad of ser-his-asp (S-H-D) amino acid residues.	Aspartic Acid	221-224	acetyl-CoA acetyltransferase 1	Homo sapiens	166-170
18550673-6	2008	In contrast, peptides bearing Glu-Ala or Gln-Asp at the scissile bond (NS4-NS5 and NS5-NS6, or NS6-NS7 junctions, respectively) were resistant to trans cleavage by NS6 or NS6-7 proteins, whereas cis cleavage of the Glu-Ala scissile bond of the NS5-NS6 junction was evidenced.	Aspartic Acid	45-48	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	71-74
18508922-3	2008	This cleavage is group I or III caspase dependent in a noncanonical single site localized around the aspartic acid(128) residue and leads to the separation of the N- and C-terminal parts of U2AF65.	Aspartic Acid	101-114	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	190-196
18445710-4	2008	We have examined the cellular mechanisms underlying alpha7 and beta2(*) nAChR-mediated [(3)H]d-aspartate release from the PFC in vitro.	Aspartic Acid	95-104	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	72-77
18445710-11	2008	Thus, beta2(*) and alpha7 nAChR subtypes in the PFC mediate [(3)H]d-aspartate release via distinct mechanisms as a result of their differential coupling to VOCCs and Ca(2+)-induced Ca(2+) release (CICR), respectively.	Aspartic Acid	68-77	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	26-31
18502759-9	2008	The results show that introducing alanine in positions Glu(9), Asp(12), Phe(16), Leu(54), and Glu(58) results in a significant reduction in IGF-I receptor binding affinity, whereas alanine substitution at position 53 had no effect on IGF-I receptor binding.	Aspartic Acid	63-66	insulin like growth factor 1 receptor	Homo sapiens	140-154
18567810-1	2008	Although their amino acid sequences and structure closely resemble DNA methyltransferases, Dnmt2 proteins were recently shown by Goll and colleagues to function as RNA methyltransferases transferring a methyl group to the C5 position of C38 in tRNA(Asp).	Aspartic Acid	249-252	tRNA aspartic acid methyltransferase 1	Homo sapiens	91-96
18508772-5	2008	Overall, we conclude that (i) Asp-122 functions as a Na(+) sensor, binding one of two co-transported Na(+) ions, (ii) Asp-124 interacts with 7alpha-OH groups of bile acids, and (iii) apolar EL1 residues map to hydrophobic ligand pharmacophore features.	Aspartic Acid	30-33	erythrocyte membrane protein band 4.1	Homo sapiens	190-193
18508772-5	2008	Overall, we conclude that (i) Asp-122 functions as a Na(+) sensor, binding one of two co-transported Na(+) ions, (ii) Asp-124 interacts with 7alpha-OH groups of bile acids, and (iii) apolar EL1 residues map to hydrophobic ligand pharmacophore features.	Aspartic Acid	118-121	erythrocyte membrane protein band 4.1	Homo sapiens	190-193
18384503-8	2008	High and low expressions of AS genes in the roots were associated with high and low ratios of Asn/Asp transported to the shoot through xylem.	Aspartic Acid	98-101	asparagine synthetase	Glycine max	28-30
18384503-9	2008	It is concluded that nitrate (or one of its assimilatory products) leads to the induction of AS in roots of soybean and that this underlies the variations found in xylem sap Asn/Asp ratios.	Aspartic Acid	178-181	asparagine synthetase	Glycine max	93-95
18434077-5	2008	We have found that the broad-spectrum caspase inhibitor Boc-Asp-CMK induced cell death at micromolar concentrations in human leukaemia cells.	Aspartic Acid	60-63	C-X-C motif chemokine ligand 9	Homo sapiens	64-67
18434077-8	2008	The switch between apoptosis and necrosis seemed to depend upon the degree of inhibition of executioner caspases, including caspase-3/7 with Boc-Asp-CMK.	Aspartic Acid	145-148	caspase 3	Homo sapiens	124-133
18434077-8	2008	The switch between apoptosis and necrosis seemed to depend upon the degree of inhibition of executioner caspases, including caspase-3/7 with Boc-Asp-CMK.	Aspartic Acid	145-148	C-X-C motif chemokine ligand 9	Homo sapiens	149-152
18434077-11	2008	Our results further indicated that toxicity of Boc-Asp-CMK might arise from its interference with mitochondrial metabolism.	Aspartic Acid	51-54	C-X-C motif chemokine ligand 9	Homo sapiens	55-58
18508772-0	2008	Conserved aspartic acid residues lining the extracellular loop 1 of sodium-coupled bile acid transporter ASBT Interact with Na+ and 7alpha-OH moieties on the ligand cholestane skeleton.	Aspartic Acid	10-23	solute carrier family 10 member 2	Homo sapiens	105-109
18474604-7	2008	A single amino acid substitution of Asp at residue position 218 of TRAIL to His or Tyr was predicted to have a favorable effect on DR4 binding specificity.	Aspartic Acid	36-39	TNF superfamily member 10	Homo sapiens	67-72
18474604-7	2008	A single amino acid substitution of Asp at residue position 218 of TRAIL to His or Tyr was predicted to have a favorable effect on DR4 binding specificity.	Aspartic Acid	36-39	TNF receptor superfamily member 10a	Homo sapiens	131-134
18490453-8	2008	Mutation of the TRPM6 autophosphorylation site, Thr(1851), into either an alanine or an aspartate, resulted in functional channels that could still be inhibited by ATP.	Aspartic Acid	88-97	transient receptor potential cation channel subfamily M member 6	Homo sapiens	16-21
18477468-3	2008	Mutation of Akt1 protein, exchanging the activation-essential Ser473 and Thr308 residues for inactive Ala or phosphorylation-mimicking Asp and Glu residues, revealed that phosphorylation of Ser473 represented an essential prerequisite for auto-phosphorylation of Thr308 within the Akt1 protein in keratinocytes.	Aspartic Acid	135-138	AKT serine/threonine kinase 1	Homo sapiens	12-16
18474595-6	2008	A conserved aspartate, located toward the extracellular end of the conduction pathway and known to influence ionic selectivity, contributed to the inhibitory effect of Ca2+ on macroscopic currents mediated by 5-HT3A receptors.	Aspartic Acid	12-21	5-hydroxytryptamine receptor 3A	Homo sapiens	209-215
18366345-6	2008	Mutagenesis of Arg347 to other amino acids also decreased the inhibitory potency, with aspartate producing near total loss of CFTR(inh)-172 activity.	Aspartic Acid	87-96	CF transmembrane conductance regulator	Homo sapiens	126-130
18480054-10	2008	While Arg(11) of ADWX-1 interacts with Asp(386) in Kv1.3, Thr(28) and His(33) of ADWX-1 locate right above the selectivity filter-S6 linker of Kv1.3.	Aspartic Acid	39-42	potassium voltage-gated channel subfamily A member 3	Homo sapiens	51-56
18445588-4	2008	His --&gt; Glu/Asp mutations of the active site histidines designed to mimic the phosphorylated states reveal binding equilibria that favor phosphoryl transfer from EIN to HPr.	Aspartic Acid	15-18	haptoglobin-related protein	Homo sapiens	172-175
18588369-3	2008	Herein, we report on the presence and hematologic and molecular features of hemoglobin Q-Iran [alpha75 (EF4) Asp--&gt;His] in 20 members of 11 families including nine children and hemoglobin Setif [alpha94 (G1) Asp--&gt;Tyr] in 10 individuals from five families consisting of five children and their affected parents living in western Iran.	Aspartic Acid	109-112	GTP binding elongation factor GUF1	Homo sapiens	104-107
18387830-1	2008	Glutamyl aminopeptidase (GluAP, EC 3.4.11.7, ENPEP) is a 130-kDa homodimeric zinc metallopeptidase which specifically cleaves the N-terminal glutamate or aspartate residue of peptidic substrates such as cholecystokinin-8 or angiotensin (Ang) II, in vitro.	Aspartic Acid	154-163	glutamyl aminopeptidase	Rattus norvegicus	0-23
18387830-1	2008	Glutamyl aminopeptidase (GluAP, EC 3.4.11.7, ENPEP) is a 130-kDa homodimeric zinc metallopeptidase which specifically cleaves the N-terminal glutamate or aspartate residue of peptidic substrates such as cholecystokinin-8 or angiotensin (Ang) II, in vitro.	Aspartic Acid	154-163	glutamyl aminopeptidase	Rattus norvegicus	25-30
18387830-1	2008	Glutamyl aminopeptidase (GluAP, EC 3.4.11.7, ENPEP) is a 130-kDa homodimeric zinc metallopeptidase which specifically cleaves the N-terminal glutamate or aspartate residue of peptidic substrates such as cholecystokinin-8 or angiotensin (Ang) II, in vitro.	Aspartic Acid	154-163	glutamyl aminopeptidase	Rattus norvegicus	45-50
18566479-1	2008	Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis.	Aspartic Acid	113-116	lipase G, endothelial type	Homo sapiens	0-18
18719395-4	2008	We examined the effects of neutralizing each of four negatively charged amino acid residues, Glu-1047, Glu-1052, Asp-1054 and Asp-1059, within the putative pore-forming region of human TRPM7.	Aspartic Acid	126-129	transient receptor potential cation channel subfamily M member 7	Homo sapiens	185-190
18719395-10	2008	Thus, it is concluded that in human TRPM7, (1) both Asp-1054 and Glu-1052, which are located near the narrowest portion in the pore"s selectivity filter, may provide the binding sites for Mg(2+) and Ca(2+), (2) Asp-1054 is an essential determinant of Mg(2+)and Ca(2+) conductivity, and (3) Glu-1052 and Asp-1059 facilitate the conduction of divalent cations.	Aspartic Acid	52-55	transient receptor potential cation channel subfamily M member 7	Homo sapiens	36-41
18719395-10	2008	Thus, it is concluded that in human TRPM7, (1) both Asp-1054 and Glu-1052, which are located near the narrowest portion in the pore"s selectivity filter, may provide the binding sites for Mg(2+) and Ca(2+), (2) Asp-1054 is an essential determinant of Mg(2+)and Ca(2+) conductivity, and (3) Glu-1052 and Asp-1059 facilitate the conduction of divalent cations.	Aspartic Acid	211-214	transient receptor potential cation channel subfamily M member 7	Homo sapiens	36-41
18719395-10	2008	Thus, it is concluded that in human TRPM7, (1) both Asp-1054 and Glu-1052, which are located near the narrowest portion in the pore"s selectivity filter, may provide the binding sites for Mg(2+) and Ca(2+), (2) Asp-1054 is an essential determinant of Mg(2+)and Ca(2+) conductivity, and (3) Glu-1052 and Asp-1059 facilitate the conduction of divalent cations.	Aspartic Acid	211-214	transient receptor potential cation channel subfamily M member 7	Homo sapiens	36-41
18513328-7	2008	Mutational analysis identified the caspase-dependent cleavage site of hScrib at the position of Asp-504.	Aspartic Acid	96-99	Death caspase-1	Drosophila melanogaster	35-42
18513328-7	2008	Mutational analysis identified the caspase-dependent cleavage site of hScrib at the position of Asp-504.	Aspartic Acid	96-99	scribble planar cell polarity protein	Homo sapiens	70-76
18553961-3	2008	Here we apply two different versions of the ASP methodology to three proteins, cytochrome P450cam, PcrA helicase, and glycogen synthase kinase 3beta (GSK3beta), and show that the method is capable of inducing significant conformational changes when compared to the X-ray crystal structures.	Aspartic Acid	44-47	glycogen synthase kinase 3 beta	Homo sapiens	118-148
18553961-3	2008	Here we apply two different versions of the ASP methodology to three proteins, cytochrome P450cam, PcrA helicase, and glycogen synthase kinase 3beta (GSK3beta), and show that the method is capable of inducing significant conformational changes when compared to the X-ray crystal structures.	Aspartic Acid	44-47	glycogen synthase kinase 3 beta	Homo sapiens	150-158
18566479-1	2008	Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis.	Aspartic Acid	113-116	lipase G, endothelial type	Homo sapiens	20-22
18434598-6	2008	Furthermore, mimicking mitotic phosphorylation of GRASP55 by using aspartic acid substitutions is sufficient to unlink the Golgi apparatus in a gene replacement assay.	Aspartic Acid	67-80	golgi reassembly stacking protein 2	Homo sapiens	50-57
18673151-6	2008	We here show that the kinetics of aspartate formation during the first 30 min (0.36 +/- 0.03 micromol g(-1) min(-1)) are altered such that glutamate, via aspartate aminotransferase, becomes the primary source of carbon when glucose-derived pyruvate is unavailable.	Aspartic Acid	34-43	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	154-180
18467526-9	2008	Docking of GnRH I and GnRH II to the human GnRH receptor molecular model revealed that Arg(8) of GnRH I makes contact with Asp(302), whereas Tyr(8) of GnRH II appears to make different contacts, suggesting these residues stabilize different receptor conformations mediating differential intracellular signaling and effects on gonadotropin and cell growth.	Aspartic Acid	123-126	gonadotropin releasing hormone 2	Homo sapiens	22-29
18467526-9	2008	Docking of GnRH I and GnRH II to the human GnRH receptor molecular model revealed that Arg(8) of GnRH I makes contact with Asp(302), whereas Tyr(8) of GnRH II appears to make different contacts, suggesting these residues stabilize different receptor conformations mediating differential intracellular signaling and effects on gonadotropin and cell growth.	Aspartic Acid	123-126	gonadotropin releasing hormone receptor	Homo sapiens	43-56
18611377-6	2008	The key active site residues and the components of the Asp*water*Mg2+ network are conserved in the catalytic cores of the mammalian signaling DAG kinases, indicating that these enzymes use the same mechanism and have similar structures as DgkB.	Aspartic Acid	55-58	diacylglycerol kinase beta	Homo sapiens	239-243
18270818-5	2008	We found that 200 microM of RGDS peptide, an inhibitor of integrins, decreased polyvalent gadolinium-induced [3H]D: -aspartate release by 26%.	Aspartic Acid	117-126	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	28-32
18381200-3	2008	Protein l-isoaspartyl (d-aspartyl) methyltransferase (PIMT) is a repair enzyme that facilitates conversion of l-isoAsp and d-Asp to l-Asp.	Aspartic Acid	132-137	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	0-52
18420586-2	2008	Here we demonstrate that the cytoplasmic tail of HER-2 is cleaved by caspases at Asp(1016)/Asp(1019) to release a approximately 47-kDa product, which is subsequently proteolyzed by caspases at Asp(1125) into an unstable 22-kDa fragment that is degraded by the proteasome and a predicted 25-kDa product.	Aspartic Acid	81-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-54
18420586-2	2008	Here we demonstrate that the cytoplasmic tail of HER-2 is cleaved by caspases at Asp(1016)/Asp(1019) to release a approximately 47-kDa product, which is subsequently proteolyzed by caspases at Asp(1125) into an unstable 22-kDa fragment that is degraded by the proteasome and a predicted 25-kDa product.	Aspartic Acid	91-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-54
18420586-2	2008	Here we demonstrate that the cytoplasmic tail of HER-2 is cleaved by caspases at Asp(1016)/Asp(1019) to release a approximately 47-kDa product, which is subsequently proteolyzed by caspases at Asp(1125) into an unstable 22-kDa fragment that is degraded by the proteasome and a predicted 25-kDa product.	Aspartic Acid	91-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-54
18441013-5	2008	Indeed, the residues Glu-297, Glu-303, and Asp-382 in the TSHR hinge region are essential for bTSH binding and partially for signal transduction.	Aspartic Acid	43-46	thyroid stimulating hormone receptor	Homo sapiens	58-62
18441013-6	2008	Side chain substitutions showed that the negative charge of Glu-297 and Asp-382 is necessary for recognition of bTSH by the hTSHR.	Aspartic Acid	72-75	thyroid stimulating hormone receptor	Homo sapiens	124-129
18381200-3	2008	Protein l-isoaspartyl (d-aspartyl) methyltransferase (PIMT) is a repair enzyme that facilitates conversion of l-isoAsp and d-Asp to l-Asp.	Aspartic Acid	132-137	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	54-58
18411280-4	2008	It does so via a pair of fingertip aspartates that can bind magnesium, placing TFIIB within a family of proteins that insert finger domains to alter the catalytic functions of RNA polymerase.	Aspartic Acid	35-45	cilia and flagella associated protein 20	Homo sapiens	79-84
18426798-4	2008	Our data suggest that a salt bridge between Arg-60 in the N terminus close to the cytoplasmic end of transmembrane segment (TM) 1 and Asp-436 at the cytoplasmic end of TM8 is stabilized by a cation-pi interaction between Arg-60 and Tyr-335 at the cytoplasmic end of TM6.	Aspartic Acid	134-137	tetraspanin 16	Homo sapiens	168-171
18422998-4	2008	Plasma fibronectin (Fn), a ligand for alpha4beta1, could link SS RBCs to monocytes, as peptides derived from both the Arg-Gly-Asp-Ser (RGDS) and CS-1 site in Fn disrupted the reticulocyte/monocyte interaction.	Aspartic Acid	126-129	fibronectin 1	Homo sapiens	7-18
19360665-1	2008	Two single nucleotide polymorphisms (SNP) within Mitochondrial Aspartate/Glutamate Carrier SLC25A12 gene have recently shown to be strongly associated with autism.	Aspartic Acid	63-72	solute carrier family 25 member 12	Homo sapiens	91-99
18422998-4	2008	Plasma fibronectin (Fn), a ligand for alpha4beta1, could link SS RBCs to monocytes, as peptides derived from both the Arg-Gly-Asp-Ser (RGDS) and CS-1 site in Fn disrupted the reticulocyte/monocyte interaction.	Aspartic Acid	126-129	fibronectin 1	Homo sapiens	20-22
17950494-5	2008	The central part of the inhibitor binds in an improved melagatran-like mode, while the structure identifies a d-tyrosine as P1 residue which forms a charged hydrogen bond with Asp 189 of thrombin.	Aspartic Acid	176-179	coagulation factor II, thrombin	Homo sapiens	187-195
18415701-1	2008	Citrin is the liver-type aspartate-glutamate carrier that resides within the inner mitochondrial membrane.	Aspartic Acid	25-34	solute carrier family 25 member 13	Homo sapiens	0-6
18364727-1	2008	Osteopontin (OPN), a large secreted glycoprotein with an arginine, glycine, aspartate (RGD) motif, can bind and signal through cellular integrin receptors.	Aspartic Acid	76-85	secreted phosphoprotein 1	Homo sapiens	0-11
18364727-1	2008	Osteopontin (OPN), a large secreted glycoprotein with an arginine, glycine, aspartate (RGD) motif, can bind and signal through cellular integrin receptors.	Aspartic Acid	76-85	secreted phosphoprotein 1	Homo sapiens	13-16
18569339-1	2008	1,2-Epoxy-3-(p-nitrophenoxy)propane (EPNP) is known to inhibit pepsin A and other aspartic proteinases by reacting with the active site aspartic acid residue(s).	Aspartic Acid	136-149	pepsinogen A5	Homo sapiens	63-71
18378702-6	2008	We further describe the crystal structure of the dehydrated form of BACE1, showing that BACE1 activity is dependent on the dynamics of a catalytically required Asp-bound water molecule, which directly affects its catalytic properties.	Aspartic Acid	160-163	beta-secretase 1	Homo sapiens	68-73
18178444-0	2008	Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population.	Aspartic Acid	0-13	asporin	Homo sapiens	41-48
18178444-2	2008	Recently, it has been reported that susceptibility to OA is affected by the number of aspartic acid (D) residues in the amino-terminal of the asporin protein.	Aspartic Acid	86-99	asporin	Homo sapiens	142-149
18378702-6	2008	We further describe the crystal structure of the dehydrated form of BACE1, showing that BACE1 activity is dependent on the dynamics of a catalytically required Asp-bound water molecule, which directly affects its catalytic properties.	Aspartic Acid	160-163	beta-secretase 1	Homo sapiens	88-93
18433405-8	2008	Significant low proportion of primary DSS were found to have TAP1(637) Asp/Asp genotypes (54.5%) when compared with primary DF (70.3%, P = 0.043).	Aspartic Acid	71-74	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	61-65
18433405-8	2008	Significant low proportion of primary DSS were found to have TAP1(637) Asp/Asp genotypes (54.5%) when compared with primary DF (70.3%, P = 0.043).	Aspartic Acid	75-78	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	61-65
18433405-11	2008	This report on TAP gene polymorphisms in dengue suggested that among the primary-infected individuals, homozygous patterns for Ile at TAP1(333) Val at TAP2(379) loci and Asp at TAP1(637) were found to be a protective factor against development of DHF and DSS, respectively.	Aspartic Acid	170-173	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	15-18
18433405-11	2008	This report on TAP gene polymorphisms in dengue suggested that among the primary-infected individuals, homozygous patterns for Ile at TAP1(333) Val at TAP2(379) loci and Asp at TAP1(637) were found to be a protective factor against development of DHF and DSS, respectively.	Aspartic Acid	170-173	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	177-181
18346458-7	2008	Superimposition of the interface residues suggested that substitution of Asp 99 (Jak3) into Glu 101 (Jak1) generated steric hindrance and a Tyr 91 to Phe 93 switch altered the shape of catalytic cleft which collectively prohibited the inhibitor binding.	Aspartic Acid	73-76	Janus kinase 3	Homo sapiens	81-85
19099775-1	2008	OBJECTIVE: Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD, OMIM #605814) is a novel autosomal recessive disease caused by mutations in the gene SLC25A13 that encodes for citrin, a liver-type aspartate/glutamate carrier located in the mitochondrial inner membrane.	Aspartic Acid	213-222	solute carrier family 25 member 13	Homo sapiens	166-174
19099775-1	2008	OBJECTIVE: Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD, OMIM #605814) is a novel autosomal recessive disease caused by mutations in the gene SLC25A13 that encodes for citrin, a liver-type aspartate/glutamate carrier located in the mitochondrial inner membrane.	Aspartic Acid	213-222	solute carrier family 25 member 13	Homo sapiens	55-61
18362146-9	2008	Blocking of integrins with an Arg-Gly-Asp-containing peptide counteracted the matrix contacts necessary to initiate the uPAR-dependent cytoskeletal rearrangements, whereas inactivation of the Rac signaling pathway in all cases suppressed the occurrence of the same events.	Aspartic Acid	38-41	plasminogen activator, urokinase receptor	Homo sapiens	120-124
18452327-9	2008	The results in this study provide the criteria for determining the H-bond structures of Asp and Glu side chains in proteins using their nuC=O bands in Fourier transform infrared spectra.	Aspartic Acid	88-91	nucleobindin 1	Homo sapiens	136-139
18346458-8	2008	Furthermore, in-silico mutagenesis of these two residues back to Asp and Tyr enabled Jak1 to accommodate WHI-P131.	Aspartic Acid	65-68	Janus kinase 1	Homo sapiens	85-89
18201853-1	2008	Two degradations of aspartate residues located in Asp-Asp motifs in the CDR3 region of a recombinant monoclonal antibody were identified and quantified after the antibody was aged in a mildly acidic buffer at elevated temperatures.	Aspartic Acid	20-29	CDR3	Homo sapiens	72-76
18201853-1	2008	Two degradations of aspartate residues located in Asp-Asp motifs in the CDR3 region of a recombinant monoclonal antibody were identified and quantified after the antibody was aged in a mildly acidic buffer at elevated temperatures.	Aspartic Acid	50-53	CDR3	Homo sapiens	72-76
18201853-1	2008	Two degradations of aspartate residues located in Asp-Asp motifs in the CDR3 region of a recombinant monoclonal antibody were identified and quantified after the antibody was aged in a mildly acidic buffer at elevated temperatures.	Aspartic Acid	54-57	CDR3	Homo sapiens	72-76
18396871-2	2008	A novel block catiomer, PEG-SS-P[Asp(DET)], was designed as follows: (i) insertion of biocleavable disulfide linkage between PEG and polycation segment to trigger PEG detachment and (ii) a cationic segment based on poly(aspartamide) with a flanking N-(2-aminoethyl)-2-aminoethyl group, P[Asp(DET)], in which the Asp(DET) unit acts as a buffering moiety inducing endosomal escape with minimal cytotoxicity.	Aspartic Acid	33-36	progestagen associated endometrial protein	Homo sapiens	24-27
18396871-2	2008	A novel block catiomer, PEG-SS-P[Asp(DET)], was designed as follows: (i) insertion of biocleavable disulfide linkage between PEG and polycation segment to trigger PEG detachment and (ii) a cationic segment based on poly(aspartamide) with a flanking N-(2-aminoethyl)-2-aminoethyl group, P[Asp(DET)], in which the Asp(DET) unit acts as a buffering moiety inducing endosomal escape with minimal cytotoxicity.	Aspartic Acid	33-36	progestagen associated endometrial protein	Homo sapiens	125-128
18396871-2	2008	A novel block catiomer, PEG-SS-P[Asp(DET)], was designed as follows: (i) insertion of biocleavable disulfide linkage between PEG and polycation segment to trigger PEG detachment and (ii) a cationic segment based on poly(aspartamide) with a flanking N-(2-aminoethyl)-2-aminoethyl group, P[Asp(DET)], in which the Asp(DET) unit acts as a buffering moiety inducing endosomal escape with minimal cytotoxicity.	Aspartic Acid	33-36	progestagen associated endometrial protein	Homo sapiens	125-128
18396871-4	2008	The PEG-SS-P[Asp(DET)] micelles showed both a 1-3 orders of magnitude higher gene transfection efficiency and a more rapid onset of gene expression than PEG-P[Asp(DET)] micelles without disulfide linkages, due to much more effective endosomal escape based on the PEG detachment in endosome.	Aspartic Acid	13-16	progestagen associated endometrial protein	Homo sapiens	4-7
18396871-2	2008	A novel block catiomer, PEG-SS-P[Asp(DET)], was designed as follows: (i) insertion of biocleavable disulfide linkage between PEG and polycation segment to trigger PEG detachment and (ii) a cationic segment based on poly(aspartamide) with a flanking N-(2-aminoethyl)-2-aminoethyl group, P[Asp(DET)], in which the Asp(DET) unit acts as a buffering moiety inducing endosomal escape with minimal cytotoxicity.	Aspartic Acid	288-291	progestagen associated endometrial protein	Homo sapiens	24-27
18396871-4	2008	The PEG-SS-P[Asp(DET)] micelles showed both a 1-3 orders of magnitude higher gene transfection efficiency and a more rapid onset of gene expression than PEG-P[Asp(DET)] micelles without disulfide linkages, due to much more effective endosomal escape based on the PEG detachment in endosome.	Aspartic Acid	13-16	progestagen associated endometrial protein	Homo sapiens	153-156
18396871-4	2008	The PEG-SS-P[Asp(DET)] micelles showed both a 1-3 orders of magnitude higher gene transfection efficiency and a more rapid onset of gene expression than PEG-P[Asp(DET)] micelles without disulfide linkages, due to much more effective endosomal escape based on the PEG detachment in endosome.	Aspartic Acid	13-16	progestagen associated endometrial protein	Homo sapiens	153-156
18396871-2	2008	A novel block catiomer, PEG-SS-P[Asp(DET)], was designed as follows: (i) insertion of biocleavable disulfide linkage between PEG and polycation segment to trigger PEG detachment and (ii) a cationic segment based on poly(aspartamide) with a flanking N-(2-aminoethyl)-2-aminoethyl group, P[Asp(DET)], in which the Asp(DET) unit acts as a buffering moiety inducing endosomal escape with minimal cytotoxicity.	Aspartic Acid	288-291	progestagen associated endometrial protein	Homo sapiens	24-27
18396871-4	2008	The PEG-SS-P[Asp(DET)] micelles showed both a 1-3 orders of magnitude higher gene transfection efficiency and a more rapid onset of gene expression than PEG-P[Asp(DET)] micelles without disulfide linkages, due to much more effective endosomal escape based on the PEG detachment in endosome.	Aspartic Acid	159-162	progestagen associated endometrial protein	Homo sapiens	4-7
18310074-4	2008	Furthermore, the mutation of Thr-40 within the inhibitory subunit of IPP5 into Ala eliminates the phosphorylation of IPP5 by protein kinase A and its inhibitor activity to PP1, whereas the mutation of Thr-40 within a truncated form of IPP5 into Asp can serve as a dominant active form of IPP5 in inhibiting PP1 activity.	Aspartic Acid	245-248	protein phosphatase 1 regulatory inhibitor subunit 1C	Homo sapiens	69-73
18310074-4	2008	Furthermore, the mutation of Thr-40 within the inhibitory subunit of IPP5 into Ala eliminates the phosphorylation of IPP5 by protein kinase A and its inhibitor activity to PP1, whereas the mutation of Thr-40 within a truncated form of IPP5 into Asp can serve as a dominant active form of IPP5 in inhibiting PP1 activity.	Aspartic Acid	245-248	protein phosphatase 1 regulatory inhibitor subunit 1C	Homo sapiens	117-121
18310074-4	2008	Furthermore, the mutation of Thr-40 within the inhibitory subunit of IPP5 into Ala eliminates the phosphorylation of IPP5 by protein kinase A and its inhibitor activity to PP1, whereas the mutation of Thr-40 within a truncated form of IPP5 into Asp can serve as a dominant active form of IPP5 in inhibiting PP1 activity.	Aspartic Acid	245-248	protein phosphatase 1 regulatory inhibitor subunit 1C	Homo sapiens	117-121
18310074-4	2008	Furthermore, the mutation of Thr-40 within the inhibitory subunit of IPP5 into Ala eliminates the phosphorylation of IPP5 by protein kinase A and its inhibitor activity to PP1, whereas the mutation of Thr-40 within a truncated form of IPP5 into Asp can serve as a dominant active form of IPP5 in inhibiting PP1 activity.	Aspartic Acid	245-248	protein phosphatase 1 regulatory inhibitor subunit 1C	Homo sapiens	117-121
18309328-6	2008	We used positional-scanning peptide libraries to define the P1-P4 peptide sequence preferences of DRONC, and show that it is indeed equally active on optimized tetrapeptides containing either Asp or Glu in P1.	Aspartic Acid	192-195	Death regulator Nedd2-like caspase	Drosophila melanogaster	98-103
18215127-8	2008	Docking showed the major component of the interaction site on AChE to be the acidic sequence Arg(90)-Glu-Leu-Ser-Glu-Asp(95) on the omega loop, and also the involvement of Pro(40)-Pro-Val(42), Arg(46) (linked to Glu(94) by a salt bridge) and the hexapeptide Asp(61)-Ala-Thr-Thr-Phe-Gln(66).	Aspartic Acid	117-120	acetylcholinesterase	Mus musculus	62-66
18309328-5	2008	Since cleavage is at a Glu residue, it has been proposed that DRONC is a dual Asp- and Glu-specific caspase.	Aspartic Acid	78-81	Death regulator Nedd2-like caspase	Drosophila melanogaster	62-67
18215127-8	2008	Docking showed the major component of the interaction site on AChE to be the acidic sequence Arg(90)-Glu-Leu-Ser-Glu-Asp(95) on the omega loop, and also the involvement of Pro(40)-Pro-Val(42), Arg(46) (linked to Glu(94) by a salt bridge) and the hexapeptide Asp(61)-Ala-Thr-Thr-Phe-Gln(66).	Aspartic Acid	258-261	acetylcholinesterase	Mus musculus	62-66
18309328-7	2008	Furthermore, mutagenesis reveals that Asp and Glu residues are equally tolerated at the primary autoprocessing site of DRONC itself.	Aspartic Acid	38-41	Death regulator Nedd2-like caspase	Drosophila melanogaster	119-124
18309328-5	2008	Since cleavage is at a Glu residue, it has been proposed that DRONC is a dual Asp- and Glu-specific caspase.	Aspartic Acid	78-81	Death caspase-1	Drosophila melanogaster	100-107
18309328-8	2008	However, when its specificity is tested on a natural substrate, the Drosophila executioner caspase DRICE, a clear preference for Asp emerges.	Aspartic Acid	129-132	Death caspase-1	Drosophila melanogaster	91-98
18309328-10	2008	DRONC does not differentiate between Asp and Glu in poor substrates, but prefers Asp when tested on a good substrate.	Aspartic Acid	81-84	Death regulator Nedd2-like caspase	Drosophila melanogaster	0-5
18379122-6	2008	In 30 patients and 33 controls the normal cytosine at position 2181 in exon 10 of TSHR gene was replaced by a guanineCresulting in the replacement of Asp (727) by Glu.	Aspartic Acid	150-153	thyroid stimulating hormone receptor	Homo sapiens	82-86
18287097-4	2008	Mutating methionine 159 (Met-159) in this helix in PLTP to aspartate (M159D) or glutamate (M159E) nearly abolished the ability of PLTP to remove cellular cholesterol and dramatically reduced PLTP binding to phospholipid vesicles and its phospholipid transfer activity.	Aspartic Acid	59-68	phospholipid transfer protein	Homo sapiens	51-55
18437283-7	2008	The constructed model showed a typical alpha/beta-hydrolase fold, and confirmed the presence of a canonical catalytic triad consisting of Ser, Asp and His.	Aspartic Acid	143-146	PSHA_RS05245	Pseudoalteromonas haloplanktis TAC125	39-59
19240311-0	2008	Lack of association between Glu(298) asp polymorphism of endothelial nitric oxide synthase (eNOS) gene and coronary artery disease in Tamilian population.	Aspartic Acid	37-40	nitric oxide synthase 3	Homo sapiens	57-90
19240311-0	2008	Lack of association between Glu(298) asp polymorphism of endothelial nitric oxide synthase (eNOS) gene and coronary artery disease in Tamilian population.	Aspartic Acid	37-40	nitric oxide synthase 3	Homo sapiens	92-96
18525176-3	2008	The amino acid encoded at 752 of ORF30 in 01c1 was asparagic acid; asparagine was encoded in the other EHV-1 strains isolated from Japanese horses.	Aspartic Acid	51-65	DNA polymerase catalytic subunit	Equid alphaherpesvirus 1	33-38
17983645-2	2008	The plasma membrane receptor is located on integrin alphaVbeta3 at the Arg-Gly-Asp recognition site important to the binding by the integrin of extracellular matrix proteins.	Aspartic Acid	79-82	integrin subunit alpha V	Homo sapiens	43-63
18436037-1	2008	Dentin phosphophoryn (DPP) is a dentin sialophosphoprotein gene product that has an RGD motif and repeat sequences of aspartic acid and phosphoserine.	Aspartic Acid	118-131	dentin sialophosphoprotein	Homo sapiens	0-20
18436037-1	2008	Dentin phosphophoryn (DPP) is a dentin sialophosphoprotein gene product that has an RGD motif and repeat sequences of aspartic acid and phosphoserine.	Aspartic Acid	118-131	dentin sialophosphoprotein	Homo sapiens	22-25
18281275-6	2008	Other amino acids participating in AC cleavage included Arg-159 and Asp-162.	Aspartic Acid	68-71	N-acylsphingosine amidohydrolase 1	Homo sapiens	35-37
18287097-4	2008	Mutating methionine 159 (Met-159) in this helix in PLTP to aspartate (M159D) or glutamate (M159E) nearly abolished the ability of PLTP to remove cellular cholesterol and dramatically reduced PLTP binding to phospholipid vesicles and its phospholipid transfer activity.	Aspartic Acid	59-68	phospholipid transfer protein	Homo sapiens	130-134
18287097-4	2008	Mutating methionine 159 (Met-159) in this helix in PLTP to aspartate (M159D) or glutamate (M159E) nearly abolished the ability of PLTP to remove cellular cholesterol and dramatically reduced PLTP binding to phospholipid vesicles and its phospholipid transfer activity.	Aspartic Acid	59-68	phospholipid transfer protein	Homo sapiens	130-134
18234674-6	2008	The selective reduction in affinity for CRF depends on glutamic acid 25 in the CRF peptide, as substitution of Glu(25) reduces the affinity for CRF-BP by approximately 2 orders of magnitude, but only in the presence of both Arg(56) and Asp(62) in human CRF-BP.	Aspartic Acid	236-239	corticotropin releasing hormone binding protein	Homo sapiens	144-150
18268017-4	2008	By generating a series of chimeric and point mutants of p38alpha and p38beta, we found two amino acid residues (Asp(145) and Leu(156) in p38alpha, Gly(145) and Val(156) in p38beta) that determine the distinct subcellular locations of p38alpha-PRAK and p38beta-PRAK.	Aspartic Acid	112-115	mitogen-activated protein kinase 14	Mus musculus	56-64
18268017-4	2008	By generating a series of chimeric and point mutants of p38alpha and p38beta, we found two amino acid residues (Asp(145) and Leu(156) in p38alpha, Gly(145) and Val(156) in p38beta) that determine the distinct subcellular locations of p38alpha-PRAK and p38beta-PRAK.	Aspartic Acid	112-115	mitogen-activated protein kinase 11	Mus musculus	69-76
18268017-4	2008	By generating a series of chimeric and point mutants of p38alpha and p38beta, we found two amino acid residues (Asp(145) and Leu(156) in p38alpha, Gly(145) and Val(156) in p38beta) that determine the distinct subcellular locations of p38alpha-PRAK and p38beta-PRAK.	Aspartic Acid	112-115	mitogen-activated protein kinase 14	Mus musculus	137-145
18268017-4	2008	By generating a series of chimeric and point mutants of p38alpha and p38beta, we found two amino acid residues (Asp(145) and Leu(156) in p38alpha, Gly(145) and Val(156) in p38beta) that determine the distinct subcellular locations of p38alpha-PRAK and p38beta-PRAK.	Aspartic Acid	112-115	mitogen-activated protein kinase 11	Mus musculus	172-179
18268017-4	2008	By generating a series of chimeric and point mutants of p38alpha and p38beta, we found two amino acid residues (Asp(145) and Leu(156) in p38alpha, Gly(145) and Val(156) in p38beta) that determine the distinct subcellular locations of p38alpha-PRAK and p38beta-PRAK.	Aspartic Acid	112-115	mitogen-activated protein kinase 14	Mus musculus	137-145
18268017-4	2008	By generating a series of chimeric and point mutants of p38alpha and p38beta, we found two amino acid residues (Asp(145) and Leu(156) in p38alpha, Gly(145) and Val(156) in p38beta) that determine the distinct subcellular locations of p38alpha-PRAK and p38beta-PRAK.	Aspartic Acid	112-115	MAP kinase-activated protein kinase 5	Mus musculus	243-247
18268017-4	2008	By generating a series of chimeric and point mutants of p38alpha and p38beta, we found two amino acid residues (Asp(145) and Leu(156) in p38alpha, Gly(145) and Val(156) in p38beta) that determine the distinct subcellular locations of p38alpha-PRAK and p38beta-PRAK.	Aspartic Acid	112-115	mitogen-activated protein kinase 11	Mus musculus	172-179
18268017-4	2008	By generating a series of chimeric and point mutants of p38alpha and p38beta, we found two amino acid residues (Asp(145) and Leu(156) in p38alpha, Gly(145) and Val(156) in p38beta) that determine the distinct subcellular locations of p38alpha-PRAK and p38beta-PRAK.	Aspartic Acid	112-115	MAP kinase-activated protein kinase 5	Mus musculus	260-264
17894412-0	2008	Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism.	Aspartic Acid	68-77	solute carrier family 25 member 12	Homo sapiens	96-104
17894412-1	2008	Evidence for a genetic association between autism and two single nucleotide polymorphisms (SNPs), rs2056202 and rs2292813, in the mitochondrial aspartate/glutamate carrier (SLC25A12) gene led us to ask whether any of the four previously identified familial traits in autism spectrum disorders (ASD) varied by these SNPs.	Aspartic Acid	144-153	solute carrier family 25 member 12	Homo sapiens	173-181
18342853-6	2008	We found a significant association of the allele Gly-637 (GGC) (p=0.00004, OR=27.30, CI=3.87-548.04) and the genotypes Asp-637/Gly-637 (p=0.01, OR=16.0, CI=2.19-631.21), Pro-661/Pro-661 (p=0.006, OR=11.30, CI=2.28-75.77) with HP.	Aspartic Acid	119-122	gamma-glutamylcyclotransferase	Homo sapiens	58-61
18006876-0	2008	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	Aspartic Acid	8-11	fibrillin 1	Homo sapiens	34-53
18393802-4	2008	We have previously shown that endoproteolysis of PS1 into NTF/CTF by presenilinase requires two critical aspartate residues, suggesting that PS1 may undergo autoproteolysis; full length PS1 complexes with NCT, PEN-2, APH-1 and forms the presenilinase.	Aspartic Acid	105-114	presenilin 1	Homo sapiens	49-52
18393802-4	2008	We have previously shown that endoproteolysis of PS1 into NTF/CTF by presenilinase requires two critical aspartate residues, suggesting that PS1 may undergo autoproteolysis; full length PS1 complexes with NCT, PEN-2, APH-1 and forms the presenilinase.	Aspartic Acid	105-114	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	62-65
18393802-5	2008	While these two aspartate residues are necessary for the endoproteolysis of full length PS1, they are equally critical for the gamma-secretase cleavage of multiple substrates, and it is hypothesized that the full length PS1/presenilinase is the zymogen of gamma-secretase.	Aspartic Acid	16-25	presenilin 1	Homo sapiens	88-91
18393802-5	2008	While these two aspartate residues are necessary for the endoproteolysis of full length PS1, they are equally critical for the gamma-secretase cleavage of multiple substrates, and it is hypothesized that the full length PS1/presenilinase is the zymogen of gamma-secretase.	Aspartic Acid	16-25	presenilin 1	Homo sapiens	220-223
18305230-2	2008	To elucidate the molecular basis of the substrate recognition by hMATE1, we substituted the glutamate residues Glu273, Glu278, Glu300, and Glu389, which are conserved in the transmembrane regions, for alanine or aspartate and examined the transport activities of the resulting mutant proteins using tetraethylammonium (TEA) and cimetidine as substrates after expression in human embryonic kidney 293 (HEK-293) cells.	Aspartic Acid	212-221	solute carrier family 47 member 1	Homo sapiens	65-71
18179816-4	2008	RESULTS: Genomic and cDNA sequencing demonstrated a novel NEMO missense mutation, 337G->A, predicted to cause a D113N (aspartic acid to asparagine) substitution in the first coiled-coil region of the NEMO protein.	Aspartic Acid	119-132	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	58-62
18381895-3	2008	Here we show that the mitochondrial components of the malate-aspartate NADH shuttle (Mdh1 [malate dehydrogenase] and Aat1 [aspartate amino transferase]) and the glycerol-3-phosphate shuttle (Gut2, glycerol-3-phosphate dehydrogenase) are novel longevity factors in the CR pathway in yeast.	Aspartic Acid	61-70	malate dehydrogenase MDH1	Saccharomyces cerevisiae S288C	85-89
18381895-3	2008	Here we show that the mitochondrial components of the malate-aspartate NADH shuttle (Mdh1 [malate dehydrogenase] and Aat1 [aspartate amino transferase]) and the glycerol-3-phosphate shuttle (Gut2, glycerol-3-phosphate dehydrogenase) are novel longevity factors in the CR pathway in yeast.	Aspartic Acid	61-70	aspartate transaminase AAT1	Saccharomyces cerevisiae S288C	117-121
18381895-3	2008	Here we show that the mitochondrial components of the malate-aspartate NADH shuttle (Mdh1 [malate dehydrogenase] and Aat1 [aspartate amino transferase]) and the glycerol-3-phosphate shuttle (Gut2, glycerol-3-phosphate dehydrogenase) are novel longevity factors in the CR pathway in yeast.	Aspartic Acid	61-70	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	191-195
18381895-3	2008	Here we show that the mitochondrial components of the malate-aspartate NADH shuttle (Mdh1 [malate dehydrogenase] and Aat1 [aspartate amino transferase]) and the glycerol-3-phosphate shuttle (Gut2, glycerol-3-phosphate dehydrogenase) are novel longevity factors in the CR pathway in yeast.	Aspartic Acid	61-70	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	197-231
18228204-13	2008	NOR proteins and osteopontin are proteins containing aspartic acid rich regions that can bind Ag.	Aspartic Acid	53-66	secreted phosphoprotein 1	Homo sapiens	17-28
18179816-4	2008	RESULTS: Genomic and cDNA sequencing demonstrated a novel NEMO missense mutation, 337G->A, predicted to cause a D113N (aspartic acid to asparagine) substitution in the first coiled-coil region of the NEMO protein.	Aspartic Acid	119-132	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	200-204
18174385-3	2008	We investigated the role of the conserved, negatively charged aspartate at position 2.63 in cannabinoid receptor (CB(1)) function by substituting it with asparagine (D2.63N) and glutamate (D2.63E).	Aspartic Acid	62-71	cannabinoid receptor 1	Homo sapiens	114-119
18180767-4	2008	SLC25A12 encodes the mitochondrial aspartate/glutamate carrier functionally important in neurons with high-metabolic activity.	Aspartic Acid	35-44	solute carrier family 25 member 12	Homo sapiens	0-8
18042364-6	2008	This region of fibronectin contains the Arg-Gly-Asp sequence recognized by alpha5beta1 integrin, but deletion of that sequence does not prevent TSG-6 binding, and TSG-6 does not inhibit cell adhesion on fibronectin substrates mediated by this integrin.	Aspartic Acid	48-51	fibronectin 1	Homo sapiens	15-26
18022236-10	2008	However, in most other positions this enzyme shows amino acid preferences very similar to human chymase and mouse mast cell protease-4, i.e. aliphatic amino acids in positions P4, P3, P2 and P1", and acidic amino acids (Glu and Asp) in the P2" position.	Aspartic Acid	228-231	chymase 1	Homo sapiens	96-103
18022236-10	2008	However, in most other positions this enzyme shows amino acid preferences very similar to human chymase and mouse mast cell protease-4, i.e. aliphatic amino acids in positions P4, P3, P2 and P1", and acidic amino acids (Glu and Asp) in the P2" position.	Aspartic Acid	228-231	protease 4	Mus musculus	124-134
17985355-7	2008	EXC-4 differs from other CLIC proteins in that the conserved redox-active cysteine at the N-terminus of helix 1 is replaced by an aspartic acid residue.	Aspartic Acid	130-143	Chloride intracellular channel exc-4	Caenorhabditis elegans	0-5
18178557-6	2008	We show that the sensitization is accompanied by a decrease of Ca(2+)-dependent channel inhibition mediated by calmodulin acting at an N-terminal site (amino acids 108-130) and by an acidic residue (Asp(641)) at the pore loop of TRPV3.	Aspartic Acid	199-202	transient receptor potential cation channel subfamily V member 3	Homo sapiens	229-234
18393239-6	2008	The mutation is a 9 base pair(bp) deletion in exon 5 (c.483del9) that results in a putative PAX6 protein with in-frame deletions of aspartic acid, isoleucine and serine at the amino acids 41-43.	Aspartic Acid	132-145	paired box 6	Homo sapiens	92-96
18031291-1	2008	The OXA-1 beta-lactamase is one of the few class D enzymes that has an aspartate residue at position 66, a position that is proximal to the active-site residue Ser(67).	Aspartic Acid	71-80	beta-lactamase OXA-1 precursor	Escherichia coli	4-9
18031291-8	2008	Because Asp(66) forms hydrogen bonds with several other residues in the OXA-1 active site, we propose that this residue plays a role in stabilizing the CO2 bound to Lys(70) and thereby profoundly affects substrate turnover.	Aspartic Acid	8-11	beta-lactamase OXA-1 precursor	Escherichia coli	72-77
18165684-11	2008	We conclude that the highly conserved Asp-137 destabilizes the middle of Tm, resulting in a more flexible region that is important for the cooperative activation of the thin filament by myosin.	Aspartic Acid	38-41	myosin heavy chain 14	Homo sapiens	186-192
18280666-10	2008	Furthermore, alanine substitutions of T341 and S385 to disrupt the potential ERK phosphorylation sites present in the Kir6.2 subunit significantly abrogated the stimulatory effects of ERK2, while aspartate substitutions of T341 and S385 to mimic the (negative) charge effect of phosphorylation rendered a small yet significant reduction in the ATP sensitivity of the channel.	Aspartic Acid	196-205	mitogen-activated protein kinase 1	Homo sapiens	77-80
18280666-10	2008	Furthermore, alanine substitutions of T341 and S385 to disrupt the potential ERK phosphorylation sites present in the Kir6.2 subunit significantly abrogated the stimulatory effects of ERK2, while aspartate substitutions of T341 and S385 to mimic the (negative) charge effect of phosphorylation rendered a small yet significant reduction in the ATP sensitivity of the channel.	Aspartic Acid	196-205	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	118-124
18191824-2	2008	CYP2D1 has amino acid residues, leucine and valine, at positions of 216 and 219, respectively, whereas CYP2D2 has phenylalanine and aspartic acid at the same positions.	Aspartic Acid	132-145	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	103-109
18349268-7	2008	Subtle but significant cancer risk was observed for the XPD Asp 312 Asn polymorphism in bladder cancer (for Asp/Asn versus Asp/Asp: OR, 1.24; 95% CI, 1.06-1.46).	Aspartic Acid	60-63	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	56-59
18191824-3	2008	In reduced carbon monoxide-difference spectroscopic analysis, the substitution of Asp-219 of CYP2D2 by valine markedly increased a peak at 450 nm and concomitantly decreased a peak at 420 nm, while the replacement of Phe-216 of CYP2D2 with leucine gave no observable change.	Aspartic Acid	82-85	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	93-99
18191824-3	2008	In reduced carbon monoxide-difference spectroscopic analysis, the substitution of Asp-219 of CYP2D2 by valine markedly increased a peak at 450 nm and concomitantly decreased a peak at 420 nm, while the replacement of Phe-216 of CYP2D2 with leucine gave no observable change.	Aspartic Acid	82-85	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	228-234
18191824-5	2008	The substitution of Val-219 of CYP2D1 by aspartic acid decreased the CYP content to one-half, whereas the replacement of Leu-216 with phenylalanine did not have any effect.	Aspartic Acid	41-54	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	31-37
18191824-5	2008	The substitution of Val-219 of CYP2D1 by aspartic acid decreased the CYP content to one-half, whereas the replacement of Leu-216 with phenylalanine did not have any effect.	Aspartic Acid	41-54	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	31-34
18191824-6	2008	The double substitution of Leu-216 and Val-219 of CYP2D1 by phenylalanine and aspartic acid, respectively, diminished the CYP content by 90%.	Aspartic Acid	78-91	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	50-56
18191824-6	2008	The double substitution of Leu-216 and Val-219 of CYP2D1 by phenylalanine and aspartic acid, respectively, diminished the CYP content by 90%.	Aspartic Acid	78-91	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	50-53
27264151-1	2008	The first observation of homozygote Hb Q-Iran (alpha1 75(EF4) Asp-His) is presented in this report.	Aspartic Acid	62-65	GTP binding elongation factor GUF1	Homo sapiens	57-60
18522276-1	2008	It has been shown for the first time that deacylation is the rate-limiting stage in the enteropeptidase-catalyzed hydrolysis of highly efficient oligopeptide substrates containing four Asp residues in positions P2-P5.	Aspartic Acid	185-188	transmembrane serine protease 15	Homo sapiens	88-103
18316727-5	2008	The stimulatory action of CO on the Slo1 BK channel requires an aspartic acid and two histidine residues located in the cytoplasmic RCK1 domain, and the effect persists under the conditions known to inhibit the conventional interaction between CO and heme in other proteins.	Aspartic Acid	64-77	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	36-40
18232645-2	2008	The mutants include the conversion of all 20 glutamate residues and 24 of the 25 aspartate residues in CcP, one at a time, to lysine residues.	Aspartic Acid	81-90	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	103-106
18160458-4	2008	Plasma ASP was increased by 85% in obese ob/ob leptin-deficient mice and decreased in lean diacylglycerol acyltransferase 1 (DGAT1) KO mice (-54%) and C/EBPalpha(beta/beta) transgenic mice (-70%) compared with WT.	Aspartic Acid	7-10	diacylglycerol O-acyltransferase 1	Mus musculus	91-123
18160458-4	2008	Plasma ASP was increased by 85% in obese ob/ob leptin-deficient mice and decreased in lean diacylglycerol acyltransferase 1 (DGAT1) KO mice (-54%) and C/EBPalpha(beta/beta) transgenic mice (-70%) compared with WT.	Aspartic Acid	7-10	diacylglycerol O-acyltransferase 1	Mus musculus	125-130
18160458-4	2008	Plasma ASP was increased by 85% in obese ob/ob leptin-deficient mice and decreased in lean diacylglycerol acyltransferase 1 (DGAT1) KO mice (-54%) and C/EBPalpha(beta/beta) transgenic mice (-70%) compared with WT.	Aspartic Acid	7-10	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	151-188
18160458-5	2008	Mice lacking alternative complement factor B or adipsin (FBKO or ADKO), required for ASP production, were also ASP deficient.	Aspartic Acid	111-114	complement factor B	Mus musculus	25-44
18349268-7	2008	Subtle but significant cancer risk was observed for the XPD Asp 312 Asn polymorphism in bladder cancer (for Asp/Asn versus Asp/Asp: OR, 1.24; 95% CI, 1.06-1.46).	Aspartic Acid	108-111	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	56-59
18349268-7	2008	Subtle but significant cancer risk was observed for the XPD Asp 312 Asn polymorphism in bladder cancer (for Asp/Asn versus Asp/Asp: OR, 1.24; 95% CI, 1.06-1.46).	Aspartic Acid	108-111	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	56-59
18048489-0	2008	The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.	Aspartic Acid	10-23	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	52-84
18473904-4	2008	Comparisons of the FPPS from the parasitic protozoa and search for conserved motifs revealed that FPPS from both apicomplexan and trypanosomatid parasites show characteristic conserved regions for example first aspartate rich motif (FARM) contained within II conserved domain and the second aspartate rich motif (SARM) contained within VI conserved domain.	Aspartic Acid	211-220	farnesyl diphosphate synthase	Homo sapiens	98-102
18180796-3	2008	In the present study, polymorphisms in several candidate genes, including TLR2-Arg/Gln753, TLR4-Asp/Gly299, TLR4-Thr/Ile399, CD14-159C/T and FcgammaRIIA-R/H131, were examined in 85 children with pneumococcal sepsis as an invasive pneumococcal disease and 409 healthy blood donors as controls.	Aspartic Acid	96-99	toll like receptor 4	Homo sapiens	91-95
18473904-4	2008	Comparisons of the FPPS from the parasitic protozoa and search for conserved motifs revealed that FPPS from both apicomplexan and trypanosomatid parasites show characteristic conserved regions for example first aspartate rich motif (FARM) contained within II conserved domain and the second aspartate rich motif (SARM) contained within VI conserved domain.	Aspartic Acid	291-300	farnesyl diphosphate synthase	Homo sapiens	98-102
17851586-0	2008	Five new CYLD mutations in skin appendage tumors and evidence that aspartic acid 681 in CYLD is essential for deubiquitinase activity.	Aspartic Acid	67-80	CYLD lysine 63 deubiquitinase	Homo sapiens	88-92
17851586-6	2008	Aspartic acid 681 is highly conserved in CYLD homologues and other members of the UBP family, but does not belong to the Cys and His boxes providing the CYLD catalytic triad (Cys601, His871, and Asp889).	Aspartic Acid	0-13	CYLD lysine 63 deubiquitinase	Homo sapiens	41-45
17851586-6	2008	Aspartic acid 681 is highly conserved in CYLD homologues and other members of the UBP family, but does not belong to the Cys and His boxes providing the CYLD catalytic triad (Cys601, His871, and Asp889).	Aspartic Acid	0-13	ubiquitin specific peptidase 1	Homo sapiens	82-85
17701959-0	2008	Dimerization of a PACAP peptide analogue in DMSO via asparagine and aspartic acid residues.	Aspartic Acid	68-81	adenylate cyclase activating polypeptide 1	Homo sapiens	18-23
18006672-5	2008	RESULTS: Screening of the GJA8 gene identified a 139 G to A transition that resulted in the replacement of aspartic acid by asparagine (D47N) in the coding region of Cx50.	Aspartic Acid	107-120	gap junction protein alpha 8	Homo sapiens	26-30
18006672-5	2008	RESULTS: Screening of the GJA8 gene identified a 139 G to A transition that resulted in the replacement of aspartic acid by asparagine (D47N) in the coding region of Cx50.	Aspartic Acid	107-120	gap junction protein alpha 8	Homo sapiens	166-170
18195689-10	2008	Mutation of one of the aspartic acid residues in the napsin A catalytic site inactivated enzymatic activity, but did not influence the ability to suppress colony formation in soft agar and tumor formation.	Aspartic Acid	23-36	napsin A aspartic peptidase	Homo sapiens	53-61
18207650-8	2008	Consistently, the inhibition pattern of aspartate transport and its stimulation by phorbol esters are indicative of a transport process due to EAAC1 operation.	Aspartic Acid	40-49	solute carrier family 1 member 1	Rattus norvegicus	143-148
18260012-6	2008	In the selected DNA binding peptides, aromatic amino acids such as histidine for CORE and glutamine/aspartic acid for AP2 were found to be abundant amino acids.	Aspartic Acid	100-113	transcription factor AP-2 alpha	Homo sapiens	118-121
18319618-4	2008	The cleavage site of HAX-1, at Asp(127), was located using N-terminal amino acid sequencing of in vitro cleavage products of recombinant HAX-1.	Aspartic Acid	31-34	HCLS1 associated protein X-1	Homo sapiens	21-26
18319618-4	2008	The cleavage site of HAX-1, at Asp(127), was located using N-terminal amino acid sequencing of in vitro cleavage products of recombinant HAX-1.	Aspartic Acid	31-34	HCLS1 associated protein X-1	Homo sapiens	137-142
18319619-1	2008	The Glu/Asp(7.32) residue in extracellular loop 3 of the mammalian type-I gonadotropin-releasing hormone receptor (GnRHR) interacts with Arg(8) of GnRH-I, conferring preferential ligand selectivity for GnRH-I over GnRH-II.	Aspartic Acid	8-11	gonadotropin releasing hormone receptor	Homo sapiens	74-113
18319619-1	2008	The Glu/Asp(7.32) residue in extracellular loop 3 of the mammalian type-I gonadotropin-releasing hormone receptor (GnRHR) interacts with Arg(8) of GnRH-I, conferring preferential ligand selectivity for GnRH-I over GnRH-II.	Aspartic Acid	8-11	gonadotropin releasing hormone receptor	Homo sapiens	115-120
18319619-1	2008	The Glu/Asp(7.32) residue in extracellular loop 3 of the mammalian type-I gonadotropin-releasing hormone receptor (GnRHR) interacts with Arg(8) of GnRH-I, conferring preferential ligand selectivity for GnRH-I over GnRH-II.	Aspartic Acid	8-11	gonadotropin releasing hormone 2	Homo sapiens	214-221
18232715-5	2008	In addition, isomerization of Asp-92 showed a decrease in in vitro potency as measured by a cell proliferation assay with a 32D cell line that expressed the full-length human EGFR.	Aspartic Acid	30-33	epidermal growth factor receptor	Homo sapiens	175-179
17904828-2	2008	For this purpose chitosan membranes were prepared and then photochemically modified with the cell adhesive peptide RGDS (Arg-Gly-Asp-Ser).	Aspartic Acid	129-132	ral guanine nucleotide dissociation stimulator	Mus musculus	115-119
18083711-7	2008	Molecular modeling supports the conclusion that Arg(10) in the D domain of caspase-9 interacts with Asp(160) in the TTCD motif of ERK2.	Aspartic Acid	100-103	caspase 9	Homo sapiens	75-84
18083711-7	2008	Molecular modeling supports the conclusion that Arg(10) in the D domain of caspase-9 interacts with Asp(160) in the TTCD motif of ERK2.	Aspartic Acid	100-103	mitogen-activated protein kinase 1	Homo sapiens	130-134
18250299-4	2008	The binding site for the LDLR EGF-A domain resides on the surface of PCSK9"s subtilisin-like catalytic domain containing Asp-374, a residue for which a gain-of-function mutation (Asp-374-Tyr) increases the affinity of PCSK9 toward LDLR and increases plasma LDL-cholesterol (LDL-C) levels in humans.	Aspartic Acid	121-124	low density lipoprotein receptor	Homo sapiens	25-29
18197701-10	2008	Conversely, upon replacement of the ancestral Glu with Asp at the -Z position of EF-III, CIB1 gained affinity for alphaIIb, and the Ca2+ affinity of CIB1 shifted into a range where the protein is able to act as an intracellular Ca2+ sensor.	Aspartic Acid	55-58	calcium and integrin binding 1	Homo sapiens	89-93
18197701-10	2008	Conversely, upon replacement of the ancestral Glu with Asp at the -Z position of EF-III, CIB1 gained affinity for alphaIIb, and the Ca2+ affinity of CIB1 shifted into a range where the protein is able to act as an intracellular Ca2+ sensor.	Aspartic Acid	55-58	calcium and integrin binding 1	Homo sapiens	149-153
18191867-5	2008	Heteronuclear multiple bond coherence spectroscopy (HMBC) was applied to characterize DP-2 as an aspartic acid derivative of amlodipine by detecting long-range CH correlations.	Aspartic Acid	97-110	transcription factor Dp-2	Homo sapiens	86-90
18287812-2	2008	In this study we found that Rad53 protein variants in which alanine and/or aspartate replace the threonine residues 354 and/or 358 do not retain kinase activity and do not undergo auto-phosphorylation, leading to defect in the checkpoint response and iper-sensitivity to DNA damage and DNA replication stress agents.	Aspartic Acid	75-84	checkpoint kinase 2	Homo sapiens	28-33
18250299-4	2008	The binding site for the LDLR EGF-A domain resides on the surface of PCSK9"s subtilisin-like catalytic domain containing Asp-374, a residue for which a gain-of-function mutation (Asp-374-Tyr) increases the affinity of PCSK9 toward LDLR and increases plasma LDL-cholesterol (LDL-C) levels in humans.	Aspartic Acid	121-124	proprotein convertase subtilisin/kexin type 9	Homo sapiens	69-74
18250299-4	2008	The binding site for the LDLR EGF-A domain resides on the surface of PCSK9"s subtilisin-like catalytic domain containing Asp-374, a residue for which a gain-of-function mutation (Asp-374-Tyr) increases the affinity of PCSK9 toward LDLR and increases plasma LDL-cholesterol (LDL-C) levels in humans.	Aspartic Acid	121-124	proprotein convertase subtilisin/kexin type 9	Homo sapiens	218-223
18250299-4	2008	The binding site for the LDLR EGF-A domain resides on the surface of PCSK9"s subtilisin-like catalytic domain containing Asp-374, a residue for which a gain-of-function mutation (Asp-374-Tyr) increases the affinity of PCSK9 toward LDLR and increases plasma LDL-cholesterol (LDL-C) levels in humans.	Aspartic Acid	121-124	low density lipoprotein receptor	Homo sapiens	231-235
18258633-8	2008	The replacement of the residues of aspartic acid in position 5 or those of alanine in position 6 in the sequence of p10mer resulted in peptides with no activity in the activation experiments.	Aspartic Acid	35-48	S100 calcium binding protein A10	Homo sapiens	116-119
18073204-8	2008	Additionally, amino acids Ala(324) and Asp(327) in the cytoplasmic tails of HLA-A and (but not HLA-C and HLA-E) molecules also stabilized AP-1 binding.	Aspartic Acid	39-42	major histocompatibility complex, class I, A	Homo sapiens	76-81
18073204-8	2008	Additionally, amino acids Ala(324) and Asp(327) in the cytoplasmic tails of HLA-A and (but not HLA-C and HLA-E) molecules also stabilized AP-1 binding.	Aspartic Acid	39-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-142
17681377-8	2008	Interestingly, Asp and Glu are often present in position P2" of known substrates for the human chymase.	Aspartic Acid	15-18	chymase 1	Homo sapiens	95-102
17624493-0	2008	Regulation of aspartate-derived amino acid homeostasis in potato plants (Solanum tuberosum L.) by expression of E. coli homoserine kinase.	Aspartic Acid	14-23	homoserine kinase-like	Solanum tuberosum	120-137
18208385-4	2008	The present study deals with the dynamic nature of GSK3beta and highlights the importance of studying protein plasticity in structure-based drug design, exemplified by our method called ASP (active-site pressurization).	Aspartic Acid	186-189	glycogen synthase kinase 3 beta	Homo sapiens	51-59
18271919-2	2008	POEM has several characteristics of a matrix protein including an arg-gly-asp binding domain site that is recognized by integrins.	Aspartic Acid	74-77	nephronectin	Homo sapiens	0-4
17974564-3	2008	Here we have used mutagenesis, radioligand binding, voltage clamp electrophysiology, and homology modeling to probe the role of the F-loop residues Asp(192)-Arg(197) in the GABA(A) receptor gamma(2) subunit in diazepam potentiation of the GABA response.	Aspartic Acid	148-151	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	173-198
18233995-2	2008	They are trafficked and/or clustered at synapses by the post-synaptic density (PSD)-95 membrane associated guanylate kinase (MAGUK) family of scaffolding proteins that associate with NMDA receptor NR2 subunits via their C-terminal glutamate serine (aspartate/glutamate) valine motifs.	Aspartic Acid	249-258	discs large MAGUK scaffold protein 4	Mus musculus	56-86
17989718-7	2008	When these two aspartates were mutated into alanines, more intriguingly, the apoptosis-amplified action of AML1-ETO induction completely disappeared, while inducible expression of the caspase-3-cleaved 70 kDa fragment of AML1-ETO after tetracycline removal is sufficient to enhance apoptotic sensitivity.	Aspartic Acid	15-25	RUNX family transcription factor 1	Homo sapiens	107-111
17989718-7	2008	When these two aspartates were mutated into alanines, more intriguingly, the apoptosis-amplified action of AML1-ETO induction completely disappeared, while inducible expression of the caspase-3-cleaved 70 kDa fragment of AML1-ETO after tetracycline removal is sufficient to enhance apoptotic sensitivity.	Aspartic Acid	15-25	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	112-115
17989718-7	2008	When these two aspartates were mutated into alanines, more intriguingly, the apoptosis-amplified action of AML1-ETO induction completely disappeared, while inducible expression of the caspase-3-cleaved 70 kDa fragment of AML1-ETO after tetracycline removal is sufficient to enhance apoptotic sensitivity.	Aspartic Acid	15-25	caspase 3	Homo sapiens	184-193
17989718-7	2008	When these two aspartates were mutated into alanines, more intriguingly, the apoptosis-amplified action of AML1-ETO induction completely disappeared, while inducible expression of the caspase-3-cleaved 70 kDa fragment of AML1-ETO after tetracycline removal is sufficient to enhance apoptotic sensitivity.	Aspartic Acid	15-25	RUNX family transcription factor 1	Homo sapiens	221-225
17989718-7	2008	When these two aspartates were mutated into alanines, more intriguingly, the apoptosis-amplified action of AML1-ETO induction completely disappeared, while inducible expression of the caspase-3-cleaved 70 kDa fragment of AML1-ETO after tetracycline removal is sufficient to enhance apoptotic sensitivity.	Aspartic Acid	15-25	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	226-229
18080752-6	2008	VGLUT2 expression in oocytes (1) stimulated the influx of L-[(3)H]glutamate, but not D-[(3)H]aspartate, into digitonin-permeabilized oocytes and (2) stimulated efflux of L-glutamate, but not L-aspartate, from intact oocytes preinjected with (3)H-labeled amino acids.	Aspartic Acid	191-202	solute carrier family 17 (vesicular glutamate transporter), member 7 S homeolog	Xenopus laevis	0-6
18161990-5	2008	Mutation of serines 637-639 to alanine (3A) or aspartate (3D) results in an increased tyrosine kinase activity of c-Abl 3D, and a slight reduction of the activity of the 3A mutant, as compared to wild-type (WT) c-Abl.	Aspartic Acid	47-56	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	114-119
18227430-4	2008	To investigate whether this serine addition is assisted by the catalytic His-Asp dyad, we generated two mutants of DPP-IV, S630A and H740Q, and assayed them for ability to bind inhibitor.	Aspartic Acid	77-80	dipeptidyl peptidase 4	Homo sapiens	115-121
17938953-4	2008	Phosphorylation of ARR7 is inhibited in vitro by mutation in a putative phospho-accepting Asp residue into an Asn residue (ARR7(D85N)).	Aspartic Acid	90-93	response regulator 7	Arabidopsis thaliana	19-23
17938953-4	2008	Phosphorylation of ARR7 is inhibited in vitro by mutation in a putative phospho-accepting Asp residue into an Asn residue (ARR7(D85N)).	Aspartic Acid	90-93	response regulator 7	Arabidopsis thaliana	123-127
18161990-5	2008	Mutation of serines 637-639 to alanine (3A) or aspartate (3D) results in an increased tyrosine kinase activity of c-Abl 3D, and a slight reduction of the activity of the 3A mutant, as compared to wild-type (WT) c-Abl.	Aspartic Acid	47-56	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	211-216
18272036-6	2008	This mutation caused one aspartate deletion in the fourth transmembrane domain of the PTCH protein located within the sterol sensing domain (SSD).	Aspartic Acid	25-34	patched 1	Homo sapiens	86-90
17984089-8	2008	Switch II mutations also affect binding to IQGAP1 although the effects differ between Rac1 and Cdc42; mutation of either Asp-63, Arg-68, or Leu-70 abrogate Rac1 binding, whereas no switch II mutations affect Cdc42 binding to IQGAP1.	Aspartic Acid	121-124	IQ motif containing GTPase activating protein 1	Homo sapiens	43-49
18180853-7	2008	We observed that in the Glu/Asp and Asp/Asp mutant genotypes, the amount of NOS3 associated with Cav-1 was significantly lower.	Aspartic Acid	28-31	nitric oxide synthase 3	Homo sapiens	76-80
18180367-5	2008	In the cytoplasm, HuR undergoes caspase-mediated cleavage at aspartate 226.	Aspartic Acid	61-70	ELAV like RNA binding protein 1	Homo sapiens	18-21
18179707-5	2008	We use site-directed mutagenesis to demonstrate that the difference between FAX-1 and NHR-67 binding preference is partially mediated by a conserved subclass-specific asparagine or aspartate residue at position 19 of the DNA-binding domain.	Aspartic Acid	181-190	Nuclear hormone receptor family member fax-1	Caenorhabditis elegans	76-81
18179707-5	2008	We use site-directed mutagenesis to demonstrate that the difference between FAX-1 and NHR-67 binding preference is partially mediated by a conserved subclass-specific asparagine or aspartate residue at position 19 of the DNA-binding domain.	Aspartic Acid	181-190	Nuclear hormone receptor family member nhr-67	Caenorhabditis elegans	86-92
18180853-7	2008	We observed that in the Glu/Asp and Asp/Asp mutant genotypes, the amount of NOS3 associated with Cav-1 was significantly lower.	Aspartic Acid	28-31	caveolin 1	Homo sapiens	97-102
18235846-10	2008	Comparative modeling of the three-dimensional structure of E. histolytica putative ODC shows that the putative binding site for DFMO is disrupted by the substitution of three amino acids-aspartate-332, aspartate-361, and tyrosine-323-by histidine-296, phenylalanine-305, and asparagine-334, through which this inhibitor interacts with the protein.	Aspartic Acid	187-196	ornithine decarboxylase 1	Homo sapiens	83-86
18180853-7	2008	We observed that in the Glu/Asp and Asp/Asp mutant genotypes, the amount of NOS3 associated with Cav-1 was significantly lower.	Aspartic Acid	36-39	nitric oxide synthase 3	Homo sapiens	76-80
18235846-10	2008	Comparative modeling of the three-dimensional structure of E. histolytica putative ODC shows that the putative binding site for DFMO is disrupted by the substitution of three amino acids-aspartate-332, aspartate-361, and tyrosine-323-by histidine-296, phenylalanine-305, and asparagine-334, through which this inhibitor interacts with the protein.	Aspartic Acid	202-211	ornithine decarboxylase 1	Homo sapiens	83-86
18180853-7	2008	We observed that in the Glu/Asp and Asp/Asp mutant genotypes, the amount of NOS3 associated with Cav-1 was significantly lower.	Aspartic Acid	36-39	caveolin 1	Homo sapiens	97-102
18180853-7	2008	We observed that in the Glu/Asp and Asp/Asp mutant genotypes, the amount of NOS3 associated with Cav-1 was significantly lower.	Aspartic Acid	36-39	nitric oxide synthase 3	Homo sapiens	76-80
18180853-7	2008	We observed that in the Glu/Asp and Asp/Asp mutant genotypes, the amount of NOS3 associated with Cav-1 was significantly lower.	Aspartic Acid	36-39	caveolin 1	Homo sapiens	97-102
18097554-7	2008	LS174T cell line had a point mutation of the K-RAS gene at codon 12 (gly12 --&gt; asp; G12D), and HCT 116 and LoVo cell lines had a point mutation of the K-RAS gene at codon 13 (gly13 --&gt; asp; G13D).	Aspartic Acid	82-85	KRAS proto-oncogene, GTPase	Homo sapiens	45-50
17572430-1	2008	We previously identified a G&gt;A single nucleotide polymorphism (SNP) between C57BL/6J (B6) and C3H/HeJ (C3H) mouse strains at position 2077 in the coding region of Vcam1 that leads to substitution of an amino acid from aspartic acid (D) to asparagine (N) in the protein product.	Aspartic Acid	221-234	vascular cell adhesion molecule 1	Mus musculus	166-171
17845003-2	2008	Both integrins and APN recognize a broad range of peptides containing RGD (Arg-Gly-Asp) and NGR (Asn-Gly-Arg) motifs, respectively.	Aspartic Acid	83-86	alanyl aminopeptidase, membrane	Homo sapiens	19-22
18503157-0	2008	Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population.	Aspartic Acid	80-83	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	74-79
18503157-5	2008	The purpose of the present study was, therefore to investigate APE-1 genotypes (Asp/Asp, Asp/Glu, Glu/Glu) with different histological subtypes in cases compared with controls.	Aspartic Acid	80-83	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	63-68
18503157-5	2008	The purpose of the present study was, therefore to investigate APE-1 genotypes (Asp/Asp, Asp/Glu, Glu/Glu) with different histological subtypes in cases compared with controls.	Aspartic Acid	84-87	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	63-68
18503157-5	2008	The purpose of the present study was, therefore to investigate APE-1 genotypes (Asp/Asp, Asp/Glu, Glu/Glu) with different histological subtypes in cases compared with controls.	Aspartic Acid	84-87	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	63-68
19085238-5	2008	Our studies showed that, similar to DSPP, DMP1 is proteolytically processed by cleavages at X-Asp bonds.	Aspartic Acid	94-97	dentin matrix acidic phosphoprotein 1	Homo sapiens	42-46
22578863-6	2008	A point mutation in the conserved GTP-binding motif, AspXXGly (Asp to Ala) in Era (Asp-258) and Obg (Asp-212) proteins resulted in the loss of the associated activities, confirming that known key residues in well-established G-proteins are also conserved in mycobacterial homologs.	Aspartic Acid	53-56	GTPase Obg	Mycobacterium tuberculosis H37Rv	96-99
22578863-6	2008	A point mutation in the conserved GTP-binding motif, AspXXGly (Asp to Ala) in Era (Asp-258) and Obg (Asp-212) proteins resulted in the loss of the associated activities, confirming that known key residues in well-established G-proteins are also conserved in mycobacterial homologs.	Aspartic Acid	63-66	GTPase Obg	Mycobacterium tuberculosis H37Rv	96-99
22578863-6	2008	A point mutation in the conserved GTP-binding motif, AspXXGly (Asp to Ala) in Era (Asp-258) and Obg (Asp-212) proteins resulted in the loss of the associated activities, confirming that known key residues in well-established G-proteins are also conserved in mycobacterial homologs.	Aspartic Acid	63-66	GTPase Obg	Mycobacterium tuberculosis H37Rv	96-99
18054322-3	2008	We found that Ucp2-KO macrophages incubated in the presence of glutamine exhibit a lower ammonium release, a decreased respiratory rate, and an intracellular accumulation of aspartate.	Aspartic Acid	174-183	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	14-18
18654886-2	2008	We describe the clinical and hematological findings in two cases from independent families of Albanian origin, who have an interaction of the codon 59 (Gly--&gt;Asp) alpha2-globin gene variant in trans to a 3.7 kb alpha(+)-thal deletion (alpha(codon 59)alpha/-alpha).	Aspartic Acid	161-164	hemoglobin subunit alpha 2	Homo sapiens	166-179
18392553-1	2008	Deficiency of citrin, liver-type mitochondrial aspartate-glutamate carrier, is an autosomal recessive disorder caused by mutations of the SLC25A13 gene on chromosome 7q21.3 and has two phenotypes: neonatal intrahepatic cholestatic hepatitis (NICCD) and adult-onset type II citrullinemia (CTLN2).	Aspartic Acid	47-56	solute carrier family 25 member 13	Homo sapiens	14-20
17471503-7	2008	VEGF, bFGF, and GM-CSF in the EC-CM stimulated the proliferation and growth of EPCs, whereas AcSDKP (tetrapeptide NAc-Ser-Asp-Lys-Pro) in EC-CM suppressed the growth of mesenchymal stem cells (MSC) and fibroblasts.	Aspartic Acid	122-126	NLR family, pyrin domain containing 1A	Mus musculus	114-117
18403382-9	2008	However, malate metabolism by the mMDH system did not operate via a malate-OAA shuttle similarly to Ananas comosus mitochondria, but it operated via a malate-Asp shuttle similarly to Kalanchoe daigremontiana mitochondria.	Aspartic Acid	158-161	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	34-38
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Aspartic Acid	258-267	MLO-like protein 4	Zea mays	58-62
18173729-4	2008	Y701 replacement by aspartate or phenylalanine reduces receptor internalization rate and decreases the colocalization and association of TrkA with clathrin heavy chain, demonstrating that Y701 constitutes a YxxPhi (YRKF701-704) trafficking motif relevant for the regulation of receptor endocytosis.	Aspartic Acid	20-29	neurotrophic receptor tyrosine kinase 1	Homo sapiens	137-141
18173729-6	2008	Contrary to what was expected, substitution of Y701 for an Asp in order to mimic phosphorylation, impairs TrkA ability to mediate nerve growth factor-induced differentiation, although the mutant receptor retains its in vitro kinase activity.	Aspartic Acid	59-62	neurotrophic receptor tyrosine kinase 1	Homo sapiens	106-110
18505345-12	2008	The lowest residual DNA damage level was determined in subjects with the combined APE1(Asp/Asp)/hOGG1(Ser/Cys+Cys/Cys) genotypes.	Aspartic Acid	87-90	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	82-86
17928567-8	2008	Dimeric histaprodifen was docked into the binding pocket of gpH(1)R. Hydrogen bonds and electrostatic interactions were detected between dimeric histaprodifen and Asp-116, Ser-120, Lys-187, Glu-190, and Tyr-432.	Aspartic Acid	163-166	gephyrin	Homo sapiens	60-63
17959713-8	2008	Thus, we conclude that zinc and copper inhibition is due to a direct interaction of these divalent cations with ectodomain residues of the P2X(7) receptor, primarily involving combined interaction with His(62) and Asp(197) residues.	Aspartic Acid	214-217	purinergic receptor P2X 7	Homo sapiens	139-154
19005973-6	2008	This single nucleotide polymorphism (SNP) modified associations of soy isoflavones and tea consumption but not fiber intake with endometrial cancer, with the inverse association of soy intake and tea consumption being more evident for those with the Asp/Asp genotype of the SHBG gene at Asp(327)Asn (rs6259), particularly premenopausal women (P(interaction) = 0.06 and 0.02, respectively, for soy isoflavones and tea intake).	Aspartic Acid	250-253	sex hormone binding globulin	Homo sapiens	274-278
18681934-7	2008	* Root uptake of all tested amino acids, except L-aspartic acid (L-Asp), was significantly affected in double AAP5*LHT1 mutants, suggesting that these two transporters account for a major proportion of roots" uptake of amino acids at low concentrations.	Aspartic Acid	48-63	amino acid permease 5	Arabidopsis thaliana	110-114
18681934-7	2008	* Root uptake of all tested amino acids, except L-aspartic acid (L-Asp), was significantly affected in double AAP5*LHT1 mutants, suggesting that these two transporters account for a major proportion of roots" uptake of amino acids at low concentrations.	Aspartic Acid	65-70	amino acid permease 5	Arabidopsis thaliana	110-114
18158948-5	2008	The resulting pz-alpha-MSH analog reacted with the fac-[(99m)Tc(CO)(3)](+) moiety, giving [Ac-Nle(4),Asp(5),d-Phe(7),Lys(11)(pz-(99m)Tc(CO)(3))]alpha-MSH(4-11) in high yield, high specific activity and high radiochemical purity.	Aspartic Acid	101-104	pro-opiomelanocortin-alpha	Mus musculus	17-26
18158948-5	2008	The resulting pz-alpha-MSH analog reacted with the fac-[(99m)Tc(CO)(3)](+) moiety, giving [Ac-Nle(4),Asp(5),d-Phe(7),Lys(11)(pz-(99m)Tc(CO)(3))]alpha-MSH(4-11) in high yield, high specific activity and high radiochemical purity.	Aspartic Acid	101-104	msh homeobox 1	Mus musculus	23-26
18085519-4	2008	In the presented work, we investigated the effect of isomerization of Asp-7, a common non-enzymatic age-related modification found in AD-associated Abeta species, on hydrolysis of Abeta by ACE.	Aspartic Acid	70-73	amyloid beta precursor protein	Homo sapiens	148-153
18085519-4	2008	In the presented work, we investigated the effect of isomerization of Asp-7, a common non-enzymatic age-related modification found in AD-associated Abeta species, on hydrolysis of Abeta by ACE.	Aspartic Acid	70-73	amyloid beta precursor protein	Homo sapiens	180-185
18085519-4	2008	In the presented work, we investigated the effect of isomerization of Asp-7, a common non-enzymatic age-related modification found in AD-associated Abeta species, on hydrolysis of Abeta by ACE.	Aspartic Acid	70-73	angiotensin I converting enzyme	Homo sapiens	189-192
18273444-1	2007	Citrin is a mitochondrial aspartate-glutamate carrier primarily expressed in liver.	Aspartic Acid	26-35	solute carrier family 25 member 13	Homo sapiens	0-6
17923483-6	2007	Accumulation of the fluorescent dopamine transporter substrate trans-4-[4-(dimethylamino)styryl]-1-methylpyridinium (ASP(+)) in human embryonic kidney cells expressing human dopamine transporter was saturable and temperature-dependent.	Aspartic Acid	117-120	solute carrier family 6 member 3	Homo sapiens	32-52
17932029-4	2007	Alignment of sequences of the M1 family members led to the identification of Asp-221 as a significant residue of APA among the family members.	Aspartic Acid	77-80	glutamyl aminopeptidase	Homo sapiens	113-116
17932029-7	2007	These results suggest that the negative charge of Asp-221 is essential for Ca2+ modulation of the enzymatic activity of APA and causes preferential cleavage of acidic amino acid at the N-terminal end of substrate peptides.	Aspartic Acid	50-53	glutamyl aminopeptidase	Homo sapiens	120-123
17928291-3	2007	A fluorescence resonance energy transfer-based reporter of Akt action (ReAktion) reveals a conformational change that is critically dependent on the existence of a phosphorylatable threonine 308 in the activation loop, because mutations to either aspartate or alanine abolished the change.	Aspartic Acid	247-256	AKT serine/threonine kinase 1	Homo sapiens	59-62
17956868-6	2007	Further analysis including mutation of the corresponding residue in other UGT1A isoforms suggests that Asp-150 plays a major catalytic role.	Aspartic Acid	103-106	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	74-79
18076756-5	2007	We have recently generated a mouse model carrying an activated PDGFR-beta by replacing the highly conserved aspartic acid residue (D) 849 in the activating loop with asparagine (N).	Aspartic Acid	108-121	platelet derived growth factor receptor, beta polypeptide	Mus musculus	63-73
17923483-6	2007	Accumulation of the fluorescent dopamine transporter substrate trans-4-[4-(dimethylamino)styryl]-1-methylpyridinium (ASP(+)) in human embryonic kidney cells expressing human dopamine transporter was saturable and temperature-dependent.	Aspartic Acid	117-120	solute carrier family 6 member 3	Homo sapiens	174-194
17673349-6	2007	Asp, Phe or MeOH concentrations related to their CSF levels after ingestion of abuse or toxic ASP doses, when separately incubated with frontal cortex or pure AChE, resulted in a significant decrease of the enzyme activities.	Aspartic Acid	0-3	colony stimulating factor 2	Rattus norvegicus	49-52
18053222-9	2007	APE1 148 glu/glu + asp/glu genotype was associated with a decrease in logged 8-OHdG of 0.40 (95%CI -0.73, -0.07) compared to APE1 148 asp/asp.	Aspartic Acid	19-22	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-4
17673349-6	2007	Asp, Phe or MeOH concentrations related to their CSF levels after ingestion of abuse or toxic ASP doses, when separately incubated with frontal cortex or pure AChE, resulted in a significant decrease of the enzyme activities.	Aspartic Acid	0-3	acetylcholinesterase	Rattus norvegicus	159-163
17475462-8	2007	Thus, ASP and quercetin reduce the oxidative modification of apo B-100 and stabilize LDL conformation in a dose-dependent manner, acting in an additive or synergistic fashion with VC and VE.	Aspartic Acid	6-9	apolipoprotein B	Homo sapiens	61-70
17854388-6	2007	Compared with wild-type, levels of GABA, GHB, aspartate, and alanine were significantly higher in SSADH-null cortex, whereas glutamate, glutamine, and taurine were lower.	Aspartic Acid	46-55	aldhehyde dehydrogenase family 5, subfamily A1	Mus musculus	98-103
17475462-5	2007	However, a 10-25% synergy of ASP plus VC in protecting apo B-100 Trp against oxidation may result from their synergistic interaction in prolonging the lag time to oxidation.	Aspartic Acid	29-32	apolipoprotein B	Homo sapiens	55-64
18198423-11	2007	In addition; truncation at Asp-421 of the C-terminus of tau protein, as detected by Tau-C3, is also an early molecular event in tau protein aggregation prior to PHF formation in AD.	Aspartic Acid	27-30	microtubule associated protein tau	Homo sapiens	56-59
18198423-11	2007	In addition; truncation at Asp-421 of the C-terminus of tau protein, as detected by Tau-C3, is also an early molecular event in tau protein aggregation prior to PHF formation in AD.	Aspartic Acid	27-30	microtubule associated protein tau	Homo sapiens	128-131
18000314-0	2007	Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction.	Aspartic Acid	97-106	growth hormone releasing hormone	Homo sapiens	36-40
18162705-1	2007	Citrin is a liver-type mitochondrial aspartate-glutamate carrier encoded by the SLC25A13 gene, and its deficiency causes adult-onset type II citrullinemia and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD).	Aspartic Acid	37-46	solute carrier family 25 member 13	Homo sapiens	0-6
18042456-5	2007	The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition.	Aspartic Acid	81-90	cyclin-dependent serine/threonine-protein kinase PHO85	Saccharomyces cerevisiae S288C	54-59
18036099-1	2007	BACKGROUND: To elucidate the associations between the changing patterns of hepatitis B e antigen (HBeAg) levels and the emergence of tyrosine-methionine-aspartate-aspartate (YMDD) mutants in HBeAg non-seroconverted patients undergoing lamivudine therapy.	Aspartic Acid	153-162	capsid protein;pre-capsid protein	Hepatitis B virus	75-104
18036099-1	2007	BACKGROUND: To elucidate the associations between the changing patterns of hepatitis B e antigen (HBeAg) levels and the emergence of tyrosine-methionine-aspartate-aspartate (YMDD) mutants in HBeAg non-seroconverted patients undergoing lamivudine therapy.	Aspartic Acid	163-172	capsid protein;pre-capsid protein	Hepatitis B virus	75-104
17981306-0	2007	GABA transporter type 1 (GAT-1) uptake inhibition reduces stimulated aspartate and glutamate release in the dorsal spinal cord in vivo via different GABAergic mechanisms.	Aspartic Acid	69-78	solute carrier family 6 member 12	Rattus norvegicus	0-30
17981306-5	2007	Co-administration of selective antagonists for GABA(A) or GABA(B) receptors ((+)-bicuculline (100microM) or SCH 50911 (100microM), respectively) prevented the GAT-1 inhibition-induced reduction of evoked aspartate.	Aspartic Acid	204-213	solute carrier family 6 member 12	Rattus norvegicus	159-164
17973469-5	2007	Nuclear magnetic resonance (NMR), modeling, and docking studies indicate that in solution the peptide exhibits a beta-turn at residues Trp-Asp-Gly-Val and possibly binds to the hydrophobic channel of sPLA2.	Aspartic Acid	139-142	phospholipase A2 group X	Homo sapiens	200-205
18042456-5	2007	The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition.	Aspartic Acid	81-90	Pho80p	Saccharomyces cerevisiae S288C	75-80
18042456-5	2007	The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition.	Aspartic Acid	81-90	cyclin-dependent serine/threonine-protein kinase PHO85	Saccharomyces cerevisiae S288C	125-130
18042456-5	2007	The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition.	Aspartic Acid	81-90	Pho80p	Saccharomyces cerevisiae S288C	180-185
17992286-3	2007	DFT calculations were carried out at the BP86/TZP level to determine the nature of potential binding interactions with CXCR4 aspartate residues.	Aspartic Acid	125-134	PHD finger protein 20	Homo sapiens	46-49
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Aspartic Acid	143-146	peptidylprolyl isomerase B	Homo sapiens	41-45
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Aspartic Acid	143-146	basigin (Ok blood group)	Homo sapiens	73-78
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Aspartic Acid	143-146	basigin (Ok blood group)	Homo sapiens	171-176
17992286-3	2007	DFT calculations were carried out at the BP86/TZP level to determine the nature of potential binding interactions with CXCR4 aspartate residues.	Aspartic Acid	125-134	C-X-C motif chemokine receptor 4	Homo sapiens	119-124
17761670-6	2007	Replacing it with aspartate in yeast Rpn7, Yin6, and Rpn5 inactivated these proteins, and mutant human Int6 mislocalized in HeLa cells.	Aspartic Acid	18-27	proteasome regulatory particle lid subunit RPN7	Saccharomyces cerevisiae S288C	37-41
17911111-4	2007	Although replacement of the 18 endogenous cysteines of CFTR with Ser or Ala yields a Cys-less mutant that does not mature at 37 degrees C, we found that maturation could be restored if Val(510) was changed to Ala, Cys, Ser, Thr, Gly, Ala, or Asp.	Aspartic Acid	242-245	CF transmembrane conductance regulator	Homo sapiens	55-59
17761670-6	2007	Replacing it with aspartate in yeast Rpn7, Yin6, and Rpn5 inactivated these proteins, and mutant human Int6 mislocalized in HeLa cells.	Aspartic Acid	18-27	proteasome regulatory particle lid subunit RPN5	Saccharomyces cerevisiae S288C	53-57
17761670-6	2007	Replacing it with aspartate in yeast Rpn7, Yin6, and Rpn5 inactivated these proteins, and mutant human Int6 mislocalized in HeLa cells.	Aspartic Acid	18-27	eukaryotic translation initiation factor 3 subunit E	Homo sapiens	103-107
17491100-1	2007	BACKGROUND: Certain sequences present in the hypervariable region of human leucocyte antigen (HLA)-DRB1 known as the shared epitope (SE) are hypothesised to increase the risk of rheumatoid arthritis (RA), whereas alleles encoding aspartic acid at position 70 (D70 alleles) may have a protective effect.	Aspartic Acid	230-243	major histocompatibility complex, class II, DR beta 1	Homo sapiens	75-103
17873089-5	2007	In this article, we present site-directed mutagenesis-based data on AtcwINV1 showing that the aspartate (Asp)-239 residue fulfills an important role in both binding and hydrolysis of Suc.	Aspartic Acid	94-103	Glycosyl hydrolases family 32 protein	Arabidopsis thaliana	68-76
18027372-6	2007	Our results also indicate that Asp(80) and Asp(379) play a similar role in stabilizing the P-loop of KcsA and Kv1.2, respectively, but to significantly different extents.	Aspartic Acid	31-34	potassium voltage-gated channel subfamily A member 2	Homo sapiens	110-115
18027372-6	2007	Our results also indicate that Asp(80) and Asp(379) play a similar role in stabilizing the P-loop of KcsA and Kv1.2, respectively, but to significantly different extents.	Aspartic Acid	43-46	potassium voltage-gated channel subfamily A member 2	Homo sapiens	110-115
17950490-3	2007	The C-terminal conformation of [Nle(15)] gastrin-17 contained a short alpha-helix spanning the Ala(11)-Trp(14) sequence and an inverse gamma-turn centered on Nle(15) while that of [Tyr(9)-SO(3)] cholecystokinin-15 contained a short 3(10) helix spanning its Met(10) to Met(13) sequence and an inverse gamma-turn centered on Asp(14).	Aspartic Acid	323-326	gastrin	Homo sapiens	41-48
17873089-5	2007	In this article, we present site-directed mutagenesis-based data on AtcwINV1 showing that the aspartate (Asp)-239 residue fulfills an important role in both binding and hydrolysis of Suc.	Aspartic Acid	105-108	Glycosyl hydrolases family 32 protein	Arabidopsis thaliana	68-76
17924656-5	2007	This low affinity for ActRII may involve Ser-28 and Asp-33 of BMP-3, which are found only in BMP-3"s type II receptor-binding interfaces.	Aspartic Acid	52-55	activin A receptor type 2A	Homo sapiens	22-28
17960739-4	2007	After immunoprecipitation, CD9P-1 was subjected to enzymatic PNGase F cleavage of N-glycans, resulting in Asn to Asp conversion and increase in 1 mass unit.	Aspartic Acid	113-116	prostaglandin F2 receptor inhibitor	Homo sapiens	27-33
17924656-5	2007	This low affinity for ActRII may involve Ser-28 and Asp-33 of BMP-3, which are found only in BMP-3"s type II receptor-binding interfaces.	Aspartic Acid	52-55	bone morphogenetic protein 3	Homo sapiens	62-67
17964262-3	2007	A nondiscriminating aspartyl-tRNA synthetase (ND-DRS) first generates a mischarged aspartyl-tRNAAsn that dissociates from the enzyme and binds to a tRNA-dependent amidotransferase (AdT), which then converts the tRNA-bound aspartate into asparagine.	Aspartic Acid	222-231	sushi repeat containing protein X-linked	Homo sapiens	49-52
17716624-2	2007	GnT1 mutants were prepared by replacing a predicted unpaired cysteine (C121) with alanine (C121A), serine (C121S), threonine (C121T) or aspartic acid (C121D).	Aspartic Acid	136-149	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-4
17690095-3	2007	Aspartyl-tRNA synthetase (AspRS) can misacylate tRNA(Asp) with D-aspartate instead of its usual substrate, L-Asp.	Aspartic Acid	107-112	aspartyl-tRNA synthetase 1	Homo sapiens	0-24
17690095-3	2007	Aspartyl-tRNA synthetase (AspRS) can misacylate tRNA(Asp) with D-aspartate instead of its usual substrate, L-Asp.	Aspartic Acid	107-112	aspartyl-tRNA synthetase 1	Homo sapiens	26-31
17690095-5	2007	Asp presents a special problem, having pseudosymmetry broken only by its ammonium group, and AspRS must protect not only against D-Asp, but against an "inverted" orientation where the two substrate carboxylates are swapped.	Aspartic Acid	0-3	aspartyl-tRNA synthetase 1	Homo sapiens	93-98
17690095-10	2007	In contrast, we predict that AspRS is strongly protected against inverted L-Asp binding.	Aspartic Acid	74-79	aspartyl-tRNA synthetase 1	Homo sapiens	29-34
17702745-15	2007	The Tyr-to-Asp mutations that mimic the tyrosine phosphorylation in some of the putative FGFR-mediated phosphorylation sites increase the nucleotide exchange activity for RhoA without changing the activity for Rac1 or Cdc42.	Aspartic Acid	11-14	ras homolog family member A	Homo sapiens	171-175
17702745-15	2007	The Tyr-to-Asp mutations that mimic the tyrosine phosphorylation in some of the putative FGFR-mediated phosphorylation sites increase the nucleotide exchange activity for RhoA without changing the activity for Rac1 or Cdc42.	Aspartic Acid	11-14	cell division cycle 42	Homo sapiens	218-223
17704058-2	2007	The potential functional roles of 10 conserved aspartate and glutamate residues in hCNT1 were investigated by site-directed mutagenesis and heterologous expression in Xenopus oocytes.	Aspartic Acid	47-56	solute carrier family 28 member 1	Homo sapiens	83-88
17940047-2	2007	Recently, to elucidate the oligomerization pathway, we studied Abeta monomer folding and identified a decapeptide segment of Abeta, (21)Ala-(22)Glu-(23)Asp-(24)Val-(25)Gly-(26)Ser-(27)Asn-(28)Lys-(29)Gly-(30)Ala, within which turn formation appears to nucleate monomer folding.	Aspartic Acid	152-155	amyloid beta precursor protein	Homo sapiens	125-130
17720817-3	2007	Like the human aspartyl aminopeptidase, the exopeptidase activity of PfM18AAP is exclusive to N-terminal acidic amino acids, glutamate and aspartate, making this enzyme of particular interest and suggesting that it may function alongside the malaria cytosolic neutral aminopeptidases in the release of amino acids from host hemoglobin-derived peptides.	Aspartic Acid	139-148	carboxypeptidase Q	Homo sapiens	24-38
17880109-2	2007	This study was designed to evaluate the source of oxygen atoms in the covalent ester link in CYP4B1 enzymes labeled with [18O]glutamate and [18O]aspartate.	Aspartic Acid	145-154	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	93-99
17646170-4	2007	Here we report that ataxin-7 is cleaved by caspase-7, and we map two putative caspase-7 cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein.	Aspartic Acid	106-109	ataxin 7	Mus musculus	20-28
17644732-1	2007	Cited2 (cAMP-responsive elementbinding protein [CBP]/p300-interacting transactivators with glutamic acid [E] and aspartic acid [D]-rich tail 2) is a newly identified transcriptional modulator.	Aspartic Acid	113-126	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	0-6
17681953-5	2007	In cells, recombinant CUX1 proteins in which the region of cleavage was deleted or in which Asp residues were mutated to Ala, were not proteolytically processed.	Aspartic Acid	92-95	cut like homeobox 1	Homo sapiens	22-26
17646170-4	2007	Here we report that ataxin-7 is cleaved by caspase-7, and we map two putative caspase-7 cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein.	Aspartic Acid	106-109	caspase 7	Mus musculus	78-87
17646170-4	2007	Here we report that ataxin-7 is cleaved by caspase-7, and we map two putative caspase-7 cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein.	Aspartic Acid	106-109	ataxin 7	Mus musculus	151-159
17599380-3	2007	Here, we identify an HIV Env variant in the V4 region of gp120, Asp 386 (D386), that eliminates an N-linked glycosylation site at position 386, enhances viral replication in macrophages, and is present at a higher frequency in AIDS patients with HIV-associated dementia (HAD) compared with non-HAD patients.	Aspartic Acid	64-67	endogenous retrovirus group K member 20	Homo sapiens	25-28
17599380-3	2007	Here, we identify an HIV Env variant in the V4 region of gp120, Asp 386 (D386), that eliminates an N-linked glycosylation site at position 386, enhances viral replication in macrophages, and is present at a higher frequency in AIDS patients with HIV-associated dementia (HAD) compared with non-HAD patients.	Aspartic Acid	64-67	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	57-62
17909004-0	2007	Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp&gt;Tyr) polymorphism.	Aspartic Acid	95-98	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	77-84
17913921-5	2007	Mutation of Thr-276 in the fifth transmembrane domain (TM5) to alanine or aspartate prevented activation of wild-type hSERT through the PKG pathway and also blocked the inhibition of I425V activity by inhibitors of the pathway.	Aspartic Acid	74-83	tropomyosin 3	Homo sapiens	55-58
17913921-5	2007	Mutation of Thr-276 in the fifth transmembrane domain (TM5) to alanine or aspartate prevented activation of wild-type hSERT through the PKG pathway and also blocked the inhibition of I425V activity by inhibitors of the pathway.	Aspartic Acid	74-83	solute carrier family 6 member 4	Homo sapiens	118-123
17913921-5	2007	Mutation of Thr-276 in the fifth transmembrane domain (TM5) to alanine or aspartate prevented activation of wild-type hSERT through the PKG pathway and also blocked the inhibition of I425V activity by inhibitors of the pathway.	Aspartic Acid	74-83	protein kinase cGMP-dependent 1	Homo sapiens	136-139
17704829-8	2007	Mass spectrometry studies on the alkylated prohibitin localised the modified peptide and identified Asp-40 as the target for CCEU.	Aspartic Acid	100-103	prohibitin 1	Homo sapiens	43-53
17627859-6	2007	The most abundant amino acids in the P60 that account for 68.3% of the total residues are glycine (32.1%), aspartic acid (17.4%), alanine (13.6%), and glutamic acid (5.2%).	Aspartic Acid	107-120	plasma protein 1	Mus musculus	37-40
17991993-3	2007	Two of the amino acid substitutions (Phe/Ser180and Asp/Asn270) could be responsible for the difference in electrophoretic mobility of AtPrx53 allozymes.	Aspartic Acid	51-54	peroxidase 2	Arabidopsis thaliana	134-141
17316367-3	2007	Hence, Pyc1p-deficient cells share aspartate auxotrophy (Asp-) with a defect in growth on methanol as sole carbon source (Mut-).	Aspartic Acid	57-60	pyruvate carboxylase 1	Saccharomyces cerevisiae S288C	7-12
17845212-5	2007	DNA sequence analysis of nine atopic eczema patients confirmed a substitution in codon (1618) GCC (Ala(119)) to GAC (Asp(119)).	Aspartic Acid	117-120	guanylate cyclase 2C	Homo sapiens	94-97
17693006-0	2007	Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia.	Aspartic Acid	56-65	solute carrier family 25 member 12	Homo sapiens	84-92
17903175-6	2007	Substitution of a single amino acid Glu39 of murine alpha1 and alpha2 by Asp (alpha2-E39D) did not affect catalytic activity but completely abolished LIS1 binding.	Aspartic Acid	73-76	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1	Mus musculus	150-154
17982230-6	2007	Analysis of TAP1 gene polymorphism demonstrated decreased frequencies of Ile/Val genotype at codon 333, Asp/Gly genotype at codon 637, and haplotype A and B in allergic rhinitis patients when compared to controls (p&lt;0.05).	Aspartic Acid	104-107	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	12-16
18036861-10	2007	NOR proteins and osteopontin are proteins containing aspartic acid rich repeats that can bind Ag.	Aspartic Acid	53-66	secreted phosphoprotein 1	Homo sapiens	17-28
17693006-0	2007	Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia.	Aspartic Acid	56-65	solute carrier family 25 member 12	Homo sapiens	94-100
17693006-1	2007	Aralar is a mitochondrial calcium-regulated aspartate-glutamate carrier mainly distributed in brain and skeletal muscle, and involved in the transport of aspartate from mitochondria to the cytosol of a cell.	Aspartic Acid	44-53	solute carrier family 25 member 12	Homo sapiens	0-6
17693006-1	2007	Aralar is a mitochondrial calcium-regulated aspartate-glutamate carrier mainly distributed in brain and skeletal muscle, and involved in the transport of aspartate from mitochondria to the cytosol of a cell.	Aspartic Acid	154-163	solute carrier family 25 member 12	Homo sapiens	0-6
17636259-6	2007	We mutated Arg(47) of the Sdh3p subunit to Cys, Glu, and Lys and Asp(88) of the Sdh4p subunit to Asn, Glu, and Lys.	Aspartic Acid	65-68	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	80-85
17893612-5	2007	METHODS: We generated aspartic acid to glutamic acid mutations in the rat Bid protein, at the caspase 8 and granzyme B cleavage sites, and utilized recombinant adenoviruses to express this protein in hepatoma cells and in the livers of rats.	Aspartic Acid	22-35	BH3 interacting domain death agonist	Rattus norvegicus	74-77
17893612-5	2007	METHODS: We generated aspartic acid to glutamic acid mutations in the rat Bid protein, at the caspase 8 and granzyme B cleavage sites, and utilized recombinant adenoviruses to express this protein in hepatoma cells and in the livers of rats.	Aspartic Acid	22-35	granzyme B	Rattus norvegicus	108-118
17878296-3	2007	This site is not formed by the side-chain carboxylate groups from the conserved acidic residue, Asp-66 in NaK, conventionally thought to directly chelate Ca(2+) in CNG channels, but rather by the backbone carbonyl groups of residue Gly-67.	Aspartic Acid	96-99	TANK binding kinase 1	Homo sapiens	106-109
20641723-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	vitronectin	Mus musculus	31-42
20641847-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	vitronectin	Mus musculus	31-42
17717316-2	2007	The Asp/Asp genotype of the Ala140Asp polymorphism of the GSTO1 gene has been alleged to increase the risk of vascular dementia.	Aspartic Acid	4-7	glutathione S-transferase omega 1	Homo sapiens	58-63
17717316-2	2007	The Asp/Asp genotype of the Ala140Asp polymorphism of the GSTO1 gene has been alleged to increase the risk of vascular dementia.	Aspartic Acid	8-11	glutathione S-transferase omega 1	Homo sapiens	58-63
17717316-6	2007	RESULTS: Carriers of the GSTO1 Asp/Asp genotype presented with more severe and widespread atherosclerosis than noncarriers.	Aspartic Acid	31-34	glutathione S-transferase omega 1	Homo sapiens	25-30
17717316-6	2007	RESULTS: Carriers of the GSTO1 Asp/Asp genotype presented with more severe and widespread atherosclerosis than noncarriers.	Aspartic Acid	35-38	glutathione S-transferase omega 1	Homo sapiens	25-30
17717316-9	2007	GSTO1 Asp/Asp carriers showed larger areas of atherosclerosis plaques containing interleukin-1 alpha-positive material than carriers of the GSTO1 Ala-allele.	Aspartic Acid	6-9	glutathione S-transferase omega 1	Homo sapiens	0-5
17717316-9	2007	GSTO1 Asp/Asp carriers showed larger areas of atherosclerosis plaques containing interleukin-1 alpha-positive material than carriers of the GSTO1 Ala-allele.	Aspartic Acid	6-9	interleukin 1 alpha	Homo sapiens	81-100
17717316-9	2007	GSTO1 Asp/Asp carriers showed larger areas of atherosclerosis plaques containing interleukin-1 alpha-positive material than carriers of the GSTO1 Ala-allele.	Aspartic Acid	10-13	glutathione S-transferase omega 1	Homo sapiens	0-5
17717316-9	2007	GSTO1 Asp/Asp carriers showed larger areas of atherosclerosis plaques containing interleukin-1 alpha-positive material than carriers of the GSTO1 Ala-allele.	Aspartic Acid	10-13	interleukin 1 alpha	Homo sapiens	81-100
17717316-10	2007	CONCLUSIONS: The GSTO1 Asp/Asp genotype presumably modulates the severity and expansion of atherosclerosis in the circle of Willis.	Aspartic Acid	23-26	glutathione S-transferase omega 1	Homo sapiens	17-22
17717316-10	2007	CONCLUSIONS: The GSTO1 Asp/Asp genotype presumably modulates the severity and expansion of atherosclerosis in the circle of Willis.	Aspartic Acid	27-30	glutathione S-transferase omega 1	Homo sapiens	17-22
19812734-11	2007	For example, many CNS targets are based on seven transmembrane G protein-coupled receptors (7TM GPCR) which have a key aspartic acid residue known to interact with most ligands.	Aspartic Acid	119-132	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	96-100
17626008-7	2007	Interestingly, the Hsp70 binding affinity was abrogated when the residues were substituted for by acidic (Asp and Glu) ones at any position.	Aspartic Acid	106-109	heat shock protein family A (Hsp70) member 4	Homo sapiens	19-24
17449720-8	2007	Further, immunoprecipitation studies demonstrated that Asp variants had substantially less NOS3/Cav-1 association (approximately 40%) during static conditions.	Aspartic Acid	55-58	nitric oxide synthase 3	Homo sapiens	91-95
17685503-2	2007	X-ray crystallography revealed that the exocyclic amino group participated in a hydrogen bonding array with the two catalytic aspartic acids of BACE-1 (Asp(32), Asp(228)).	Aspartic Acid	126-140	beta-secretase 1	Homo sapiens	144-150
17685503-2	2007	X-ray crystallography revealed that the exocyclic amino group participated in a hydrogen bonding array with the two catalytic aspartic acids of BACE-1 (Asp(32), Asp(228)).	Aspartic Acid	152-155	beta-secretase 1	Homo sapiens	144-150
17685503-2	2007	X-ray crystallography revealed that the exocyclic amino group participated in a hydrogen bonding array with the two catalytic aspartic acids of BACE-1 (Asp(32), Asp(228)).	Aspartic Acid	161-164	beta-secretase 1	Homo sapiens	144-150
17763374-5	2007	Docking analysis indicated that the binding to D(2) and 5-HT(1A) receptors is based on (i) interaction between protonated N1 of the piperazine ring and various aspartate residues, (ii) hydrogen bonds between various moieties of the ligand and the residues of threonine, serine, histidine or tryptophane, and (iii) edge-to-face interactions of the aromatic ring of the arylpiperazine moiety with phenylalanine or tyrosine residues.	Aspartic Acid	160-169	5-hydroxytryptamine receptor 1A	Homo sapiens	56-63
17697120-5	2007	P4 Asp was present in the better inhibitors of caspase-7.	Aspartic Acid	3-6	caspase 7	Homo sapiens	47-56
17701905-3	2007	Mutation profiling of positional-candidate genes detected a heterozygous transversion (c.386A--&gt;T) in exon 3 of the gene for chromatin modifying protein-4B (CHMP4B) that was predicted to result in the nonconservative substitution of a valine residue for a phylogenetically conserved aspartic acid residue at codon 129 (p.D129V).	Aspartic Acid	286-299	charged multivesicular body protein 4B	Homo sapiens	128-158
17701905-3	2007	Mutation profiling of positional-candidate genes detected a heterozygous transversion (c.386A--&gt;T) in exon 3 of the gene for chromatin modifying protein-4B (CHMP4B) that was predicted to result in the nonconservative substitution of a valine residue for a phylogenetically conserved aspartic acid residue at codon 129 (p.D129V).	Aspartic Acid	286-299	charged multivesicular body protein 4B	Homo sapiens	160-166
17572636-4	2007	In both the wild-type ACVR1 model and template crystal structures (TbetaRI), the conserved arginine appears to form a salt bridge with an invariant aspartate residue.	Aspartic Acid	148-157	transforming growth factor beta receptor 1	Homo sapiens	67-74
17449720-8	2007	Further, immunoprecipitation studies demonstrated that Asp variants had substantially less NOS3/Cav-1 association (approximately 40%) during static conditions.	Aspartic Acid	55-58	caveolin 1	Homo sapiens	96-101
17698664-6	2007	The data demonstrated that the Ser--&gt;Asp amino acid substitution at position 466 in the haemagglutinin-neuraminidase protein resulted in decreased receptor binding and neuraminidase activity, the Ala/Thr--&gt;Thr selection in the fusion protein resulted in decreased fusion activity, and the Ile--&gt;Val substitution in the polymerase resulted in increased replicative/transcriptional activity.	Aspartic Acid	40-43	neuraminidase 1	Homo sapiens	106-119
17725716-5	2007	Replacement of all six serine residues by aspartate, mimicking constitutive phosphorylation, stimulates Rio1p kinase activity about twofold in vitro compared with wild-type or the corresponding (S &gt; A)(6) mutant proteins.	Aspartic Acid	42-51	protein kinase RIO1	Saccharomyces cerevisiae S288C	104-109
17698664-6	2007	The data demonstrated that the Ser--&gt;Asp amino acid substitution at position 466 in the haemagglutinin-neuraminidase protein resulted in decreased receptor binding and neuraminidase activity, the Ala/Thr--&gt;Thr selection in the fusion protein resulted in decreased fusion activity, and the Ile--&gt;Val substitution in the polymerase resulted in increased replicative/transcriptional activity.	Aspartic Acid	40-43	neuraminidase 1	Homo sapiens	171-184
17609201-9	2007	Substitution of Asp or Glu for Ser at amino acid residues 333 and 337 to mimic phosphorylation reduced the PP1c association with TIMAP.	Aspartic Acid	16-19	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	107-111
17886558-9	2007	Antibodies against integrin alphav or alphavbeta5 or arginine-glycine-aspartic acid-containing peptides, both of which block the vitronectin-glioma cell interactions, significantly reduced serum-induced cell migration, whereas blocking the interaction of glioma cells with fibronectin had no effect.	Aspartic Acid	70-83	vitronectin	Homo sapiens	129-140
17476526-8	2007	In correlation with the fact that AAP8 is a high affinity transporter for acidic amino acids, translocation of (14)C-labelled aspartate fed via the root system to seeds of the mutants is reduced.	Aspartic Acid	126-135	amino acid permease 8	Arabidopsis thaliana	34-38
20641670-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Aspartic Acid	131-134	vitronectin	Mus musculus	31-42
17591776-1	2007	Citrin is the liver-type mitochondrial aspartate-glutamate carrier that participates in urea, protein, and nucleotide biosynthetic pathways by supplying aspartate from mitochondria to the cytosol.	Aspartic Acid	39-48	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	0-6
17893655-9	2007	The first is a 9 base pair (bp) deletion in exon 5 (c.483del9) that makes a PAX6 protein with de novo in-frame deletions of aspartic acid, isoleucine, and serine at the amino acid codon positions 41-43.	Aspartic Acid	124-137	paired box 6	Homo sapiens	76-80
17591776-1	2007	Citrin is the liver-type mitochondrial aspartate-glutamate carrier that participates in urea, protein, and nucleotide biosynthetic pathways by supplying aspartate from mitochondria to the cytosol.	Aspartic Acid	153-162	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	0-6
17591776-2	2007	Citrin also plays a role in transporting cytosolic NADH reducing equivalents into mitochondria as a component of the malate-aspartate shuttle.	Aspartic Acid	124-133	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	0-6
18019535-4	2007	A crystal structure obtained for one of the compounds in the active site of thrombin revealed that the basic amidine group of the inhibitor was anchored to Asp 189 at the bottom of the S1 pocket.	Aspartic Acid	156-159	coagulation factor II, thrombin	Homo sapiens	76-84
17642517-3	2007	The protonation states of aspartic acids and glutamic acids can be determined (on the basis of convincing evidence) even to the modest resolution of 1.20 A as exemplified by our X-ray crystal structure refinements of Ni and Mn concanavalin A and also as indicated in the 1.26 A structure of thrombin, both of which are reported here.	Aspartic Acid	26-40	coagulation factor II, thrombin	Homo sapiens	291-299
17615373-2	2007	To test the hypothesis that beta-adrenergic phosphorylation of cTnI has a prominent role in accelerating cardiac myocyte relaxation performance we used transgenic (Tg) mice bearing near complete replacement of native cTnI with a beta-adrenergic phospho-mimetic of cTnI whereby tandem serine codons 23/24 were converted to aspartic acids (cTnI S23/24D).	Aspartic Acid	322-336	troponin I, cardiac 3	Mus musculus	63-67
17565994-10	2007	The results of kinetic studies of site-directed mutants of GmIF7GT showed that both His-15 and Asp-125, which correspond to the catalytic residues of UGT71G1 and VvGT1, are not important for GmIF7GT activity.	Aspartic Acid	95-98	isoflavone 7-O-glucosyltransferase 1	Glycine max	59-66
17461777-6	2007	Similarly, mutation of the yCdc34 phosphorylation sites to alanine, aspartate or glutamate residues altered Cdc34-SCFCdc4-mediated Sic1 ubiquitination activity.	Aspartic Acid	68-77	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	27-33
17461777-6	2007	Similarly, mutation of the yCdc34 phosphorylation sites to alanine, aspartate or glutamate residues altered Cdc34-SCFCdc4-mediated Sic1 ubiquitination activity.	Aspartic Acid	68-77	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	28-33
17461777-6	2007	Similarly, mutation of the yCdc34 phosphorylation sites to alanine, aspartate or glutamate residues altered Cdc34-SCFCdc4-mediated Sic1 ubiquitination activity.	Aspartic Acid	68-77	cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1	Saccharomyces cerevisiae S288C	131-135
17627757-3	2007	The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC&gt;AAC) is responsible for an amino-acidic change from Asp to Asn.	Aspartic Acid	181-184	major histocompatibility complex, class II, DR beta 1	Homo sapiens	23-27
17560037-2	2007	We report here the identification and characterisation of a novel naturally occurring transition that changes codon 169 from GGC (Gly) to GAC (Asp) in the human Pi class GST, GSTP1.	Aspartic Acid	143-146	gamma-glutamylcyclotransferase	Homo sapiens	125-128
17560037-2	2007	We report here the identification and characterisation of a novel naturally occurring transition that changes codon 169 from GGC (Gly) to GAC (Asp) in the human Pi class GST, GSTP1.	Aspartic Acid	143-146	glutathione S-transferase pi 1	Homo sapiens	175-180
17592510-6	2007	Adhesion assays revealed that baicalein stimulated endothelial cell adhesion to fibronectin and vitronectin, effects blocked by the synthetic peptide Arg-Gly-Asp (RGD).	Aspartic Acid	158-161	fibronectin 1	Rattus norvegicus	80-91
17592510-6	2007	Adhesion assays revealed that baicalein stimulated endothelial cell adhesion to fibronectin and vitronectin, effects blocked by the synthetic peptide Arg-Gly-Asp (RGD).	Aspartic Acid	158-161	vitronectin	Rattus norvegicus	96-107
17877151-5	2007	Cell adhesion was partially inhibited by Arg-Gly-Asp (RGD) peptide, anti-beta1 integrin suggesting that integrin beta1 receptors have roles to play in the process.	Aspartic Acid	49-52	integrin subunit beta 1	Homo sapiens	104-118
17635135-7	2007	At the base of TMs 2 and 3, Arg(151), His(155) and Glu(211) may form a loose equivalent of the Family A DRY (Asp-Arg-Tyr) motif.	Aspartic Acid	109-112	tropomyosin 3	Homo sapiens	15-26
17627757-3	2007	The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC&gt;AAC) is responsible for an amino-acidic change from Asp to Asn.	Aspartic Acid	181-184	major histocompatibility complex, class II, DR beta 1	Homo sapiens	57-61
17627757-3	2007	The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC&gt;AAC) is responsible for an amino-acidic change from Asp to Asn.	Aspartic Acid	181-184	glycine-N-acyltransferase	Homo sapiens	129-132
17545153-7	2007	Further mutagenesis studies indicate that conserved residues Glu(100) in TM2, Asp(122), Asp(126) in TM3 and Trp(258), Phe(261), His(264) in TM6 are involved in alpha-MSH binding and signaling.	Aspartic Acid	78-81	tropomyosin 3	Homo sapiens	100-103
17914225-4	2007	By computing the free energies of wild-type and mutant p53c binding to DNA and decomposing them into contributions from individual residues, the DNA-binding loss upon charge/noncharge -conserving mutation of Arg 273 was attributed not only to the loss of DNA phosphate contacts, but also to longer-range structural changes caused by the loss of the Asp 281 salt-bridge.	Aspartic Acid	349-352	tumor protein p53	Homo sapiens	55-58
17914225-5	2007	The results herein and in previous works suggest that Asp 281 plays a critical role in the sequence-specific DNA-binding function of p53c by (i)orienting Arg 273 and Arg 280 in an optimal position to interact with the phosphate and base groups of the consensus DNA, respectively, and (ii) helping to maintain the proper DNA-binding protein conformation.	Aspartic Acid	54-57	tumor protein p53	Homo sapiens	133-136
17580119-5	2007	Aspartic acid concentrations of 0.42 or 0.56mM significantly reduced the enzyme activities by 13 and 20% for hippocampal AChE and 15 and 18% for pure enzyme, respectively.	Aspartic Acid	0-13	acetylcholinesterase	Rattus norvegicus	121-125
17669278-1	2007	An Asp/His catalytic site of 10-formyltetrahydrofolate dehydrogenase (FDH) was suggested to have a similar catalytic topology with the Asp/His catalytic site of serine proteases.	Aspartic Acid	3-6	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	29-68
17669278-1	2007	An Asp/His catalytic site of 10-formyltetrahydrofolate dehydrogenase (FDH) was suggested to have a similar catalytic topology with the Asp/His catalytic site of serine proteases.	Aspartic Acid	3-6	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	70-73
17669278-1	2007	An Asp/His catalytic site of 10-formyltetrahydrofolate dehydrogenase (FDH) was suggested to have a similar catalytic topology with the Asp/His catalytic site of serine proteases.	Aspartic Acid	135-138	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	29-68
17669278-1	2007	An Asp/His catalytic site of 10-formyltetrahydrofolate dehydrogenase (FDH) was suggested to have a similar catalytic topology with the Asp/His catalytic site of serine proteases.	Aspartic Acid	135-138	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	70-73
17545153-7	2007	Further mutagenesis studies indicate that conserved residues Glu(100) in TM2, Asp(122), Asp(126) in TM3 and Trp(258), Phe(261), His(264) in TM6 are involved in alpha-MSH binding and signaling.	Aspartic Acid	78-81	proopiomelanocortin	Homo sapiens	160-169
17545153-7	2007	Further mutagenesis studies indicate that conserved residues Glu(100) in TM2, Asp(122), Asp(126) in TM3 and Trp(258), Phe(261), His(264) in TM6 are involved in alpha-MSH binding and signaling.	Aspartic Acid	88-91	tropomyosin 3	Homo sapiens	100-103
17918358-4	2007	The protein coding portion for the C-terminal half of asp-1 shows similar levels of genetic variation in a Wake County, North Carolina, sample as cox-1.	Aspartic Acid	54-57	cytochrome c oxidase subunit I	Ancylostoma caninum	146-151
17390218-13	2007	Thus, carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.	Aspartic Acid	24-27	SLC9A3 regulator 1	Homo sapiens	128-133
17390218-13	2007	Thus, carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.	Aspartic Acid	24-27	SLC9A3 regulator 1	Homo sapiens	134-139
17390218-13	2007	Thus, carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.	Aspartic Acid	24-27	PDZ domain containing 1	Homo sapiens	144-149
17390218-13	2007	Thus, carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.	Aspartic Acid	24-27	PDZ domain containing 1	Homo sapiens	150-155
17698249-4	2007	The conformation of [Nle(15)] gastrin-17 consisted of two short helices between Leu(5)-Glu(9) and Ala(11)-Trp(14), with the one helix terminating in a type I beta-turn spanning Gly(13)-Asp(16).	Aspartic Acid	185-188	gastrin	Homo sapiens	30-37
17531525-4	2007	A significant association between the APE1 Asp148Glu polymorphism and lung cancer risk was found, with adjusted odds ratios (OR) of 3.38 (p=0.001) for the Asp/Glu genotype and 2.39 (p=0.038) for the Glu/Glu genotype.	Aspartic Acid	43-46	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	38-42
17311001-2	2007	By using microarray-based expression profiling, we found that oligodendroglial tumours with 1p and 19q losses showed significantly lower expression of the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 4 gene (CITED4) at 1p34.2 as compared to tumours without 1p and 19q losses.	Aspartic Acid	210-223	CREB binding protein	Homo sapiens	155-163
17545153-7	2007	Further mutagenesis studies indicate that conserved residues Glu(100) in TM2, Asp(122), Asp(126) in TM3 and Trp(258), Phe(261), His(264) in TM6 are involved in alpha-MSH binding and signaling.	Aspartic Acid	88-91	proopiomelanocortin	Homo sapiens	160-169
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Aspartic Acid	41-44	Fc epsilon receptor II	Homo sapiens	4-8
17447891-2	2007	LRRK2 contains leucine-rich repeats, a GTPase domain, a COR [C-terminal of Roc (Ras of complex)] domain, a kinase and a WD40 (Trp-Asp 40) motif.	Aspartic Acid	130-133	leucine-rich repeat kinase 2	Rattus norvegicus	0-5
17517696-3	2007	It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated with OA of knee and hip joints in Japanese; in the three independent studies performed, the D14 allele of the ASPN polymorphism was over-represented and the D13 allele was under-represented.	Aspartic Acid	24-37	asporin	Homo sapiens	83-90
17517696-3	2007	It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated with OA of knee and hip joints in Japanese; in the three independent studies performed, the D14 allele of the ASPN polymorphism was over-represented and the D13 allele was under-represented.	Aspartic Acid	24-37	asporin	Homo sapiens	92-96
17311001-2	2007	By using microarray-based expression profiling, we found that oligodendroglial tumours with 1p and 19q losses showed significantly lower expression of the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 4 gene (CITED4) at 1p34.2 as compared to tumours without 1p and 19q losses.	Aspartic Acid	210-223	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4	Homo sapiens	262-268
17407447-7	2007	By mutating residues flanking the cleavage site, we showed that the aspartate residue at position P2" is essential for BMP-1 activity.	Aspartic Acid	68-77	bone morphogenetic protein 1	Homo sapiens	119-124
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Aspartic Acid	41-44	ADAM metallopeptidase domain 8	Homo sapiens	139-144
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Aspartic Acid	41-44	ADAM metallopeptidase domain 10	Homo sapiens	149-155
17623110-5	2007	The purified NS5 protein, but not the mutant NS5 protein with an Ala substitution at the first Asp of the RdRp-conserved GDD motif, exhibited template- and primer-dependent RNA synthesis activity using a poly(A) RNA template.	Aspartic Acid	95-98	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	13-16
17517883-5	2007	PRAS40 binding to raptor was also abolished by mutation of the major mTORC1 phosphorylation site, Ser(183), to Asp.	Aspartic Acid	111-114	AKT1 substrate 1	Homo sapiens	0-6
17517883-5	2007	PRAS40 binding to raptor was also abolished by mutation of the major mTORC1 phosphorylation site, Ser(183), to Asp.	Aspartic Acid	111-114	CREB regulated transcription coactivator 1	Mus musculus	69-75
17473281-9	2007	Our results indicated that LGR8 Asp-227 was crucial for binding INSL3 Arg-B16, whereas LGR8 Phe-131 and Gln-133 were involved in INSL3 Trp-B27 binding.	Aspartic Acid	32-35	relaxin family peptide receptor 2	Homo sapiens	27-31
17456474-3	2007	Murine aortic endothelial (MAE) cells interact via alpha(v) integrins with the integrin-binding Arg-Gly-Asp OPN sequence and adhere to immobilized OPN.	Aspartic Acid	104-107	secreted phosphoprotein 1	Mus musculus	108-111
17456474-3	2007	Murine aortic endothelial (MAE) cells interact via alpha(v) integrins with the integrin-binding Arg-Gly-Asp OPN sequence and adhere to immobilized OPN.	Aspartic Acid	104-107	secreted phosphoprotein 1	Mus musculus	147-150
17431791-5	2007	We also show that a substitution, resulting from a single nucleotide polymorphism (SNP) at (149)Asp found in certain cancer patients, strongly compromises PKCdelta-mediated phosphorylation at (146)Ser and results in cells that are relatively resistant to TNFalpha-induced apoptosis.	Aspartic Acid	96-99	protein kinase C delta	Homo sapiens	155-163
17431791-5	2007	We also show that a substitution, resulting from a single nucleotide polymorphism (SNP) at (149)Asp found in certain cancer patients, strongly compromises PKCdelta-mediated phosphorylation at (146)Ser and results in cells that are relatively resistant to TNFalpha-induced apoptosis.	Aspartic Acid	96-99	tumor necrosis factor	Homo sapiens	255-263
17437405-2	2007	During this process, caspase 9 is cleaved by caspase 3 at Asp(330), and it is often inferred that this proteolytic event represents a feedback amplification loop to accelerate apoptosis.	Aspartic Acid	58-61	caspase 9	Homo sapiens	21-30
17437405-2	2007	During this process, caspase 9 is cleaved by caspase 3 at Asp(330), and it is often inferred that this proteolytic event represents a feedback amplification loop to accelerate apoptosis.	Aspartic Acid	58-61	caspase 3	Homo sapiens	45-54
17562158-3	2007	The genetic distribution of four different CYP1B1 polymorphisms at Ala119Ser, Leu432Val, Asp(449)(C&gt;T), Asn453Ser were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products.	Aspartic Acid	89-92	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	43-49
17547456-5	2007	The amount of formed HAp was controlled by the number of ASP cycles and also through the ethanol content of the mixed solvent.	Aspartic Acid	57-60	retinoic acid receptor beta	Homo sapiens	21-24
17324556-0	2007	PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.	Aspartic Acid	110-119	phosphatase and tensin homolog	Homo sapiens	0-4
17324556-0	2007	PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.	Aspartic Acid	110-119	phosphatase and tensin homolog	Homo sapiens	223-227
17324556-5	2007	However, mutation of the homologous Asp-92 in PTEN does not significantly limit PE formation, indicating that Asp-92 does not act as the general acid.	Aspartic Acid	36-39	phosphatase and tensin homolog	Homo sapiens	46-50
17360157-2	2007	To define the mechanism by which GRK2-mediated phosphorylation modifies Smad2/3 behavior at the molecular level, we generated mutant Smads where the GRK2 phosphorylation site was replaced with an aspartic acid (D) to mimic the properties of a phospho-residue or an alanine (A) as a control.	Aspartic Acid	196-209	G protein-coupled receptor kinase 2	Homo sapiens	33-37
17470458-4	2007	Substitution of the AR at two Akt consensus sites, S215 and S792, with aspartate, which mimics phosphorylation, reduces ligand binding, ligand-dependent nuclear translocation, transcriptional activation and toxicity of expanded polyglutamine AR.	Aspartic Acid	71-80	androgen receptor	Homo sapiens	20-22
17470458-4	2007	Substitution of the AR at two Akt consensus sites, S215 and S792, with aspartate, which mimics phosphorylation, reduces ligand binding, ligand-dependent nuclear translocation, transcriptional activation and toxicity of expanded polyglutamine AR.	Aspartic Acid	71-80	AKT serine/threonine kinase 1	Homo sapiens	30-33
17470458-4	2007	Substitution of the AR at two Akt consensus sites, S215 and S792, with aspartate, which mimics phosphorylation, reduces ligand binding, ligand-dependent nuclear translocation, transcriptional activation and toxicity of expanded polyglutamine AR.	Aspartic Acid	71-80	androgen receptor	Homo sapiens	242-244
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Aspartic Acid	219-222	insulin like 3	Homo sapiens	63-68
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Aspartic Acid	219-222	relaxin family peptide receptor 2	Homo sapiens	69-73
17473281-9	2007	Our results indicated that LGR8 Asp-227 was crucial for binding INSL3 Arg-B16, whereas LGR8 Phe-131 and Gln-133 were involved in INSL3 Trp-B27 binding.	Aspartic Acid	32-35	insulin like 3	Homo sapiens	64-69
17710162-2	2007	We have previously shown that the transcriptional regulator CITED1 (CBP/p300-interacting transactivators with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain) is expressed exclusively in these nephrogenic progenitor cells and is downregulated as they differentiate to form nephronic epithelia.	Aspartic Acid	128-141	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1	Homo sapiens	60-66
17710162-2	2007	We have previously shown that the transcriptional regulator CITED1 (CBP/p300-interacting transactivators with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain) is expressed exclusively in these nephrogenic progenitor cells and is downregulated as they differentiate to form nephronic epithelia.	Aspartic Acid	128-141	CREB binding protein	Homo sapiens	68-76
17586778-2	2007	Here we report that the negatively charged N-terminal sequence (Met1-Ala-Asp-Glu-Glu5) previously deleted, and which is not conserved in highly homologous WW domain family members from yeast or certain fungi, significantly increases the stability of hPin1 WW (approximately 4 kJ mol(-1) at 65 degrees C), in the context of the 1-39 sequence based on equilibrium measurements.	Aspartic Acid	73-76	uroporphyrinogen-III C-methyltransferase	Saccharomyces cerevisiae S288C	64-68
17586778-2	2007	Here we report that the negatively charged N-terminal sequence (Met1-Ala-Asp-Glu-Glu5) previously deleted, and which is not conserved in highly homologous WW domain family members from yeast or certain fungi, significantly increases the stability of hPin1 WW (approximately 4 kJ mol(-1) at 65 degrees C), in the context of the 1-39 sequence based on equilibrium measurements.	Aspartic Acid	73-76	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	250-255
17646702-1	2007	L-asparaginase (EC 3.5.1.1) catalyzes the hydrolysis of the amide group of L-asparagine, releasing aspartate and NH4+.	Aspartic Acid	99-108	L-asparaginase	Glycine max	0-14
17412895-5	2007	We transduced CX3CL1 (fractalkine), an immunostimulatory chemokine, to the mouse MSCs ex vivo using an adenoviral vector with the Arg-Gly-Asp-4C peptide in the fiber knob.	Aspartic Acid	138-141	chemokine (C-X3-C motif) ligand 1	Mus musculus	14-20
17459880-6	2007	In contrast, collective mutation of Mnd2 phosphorylation sites to aspartic acid resulted in partial suppression of the sporulation defect.	Aspartic Acid	66-79	Mnd2p	Saccharomyces cerevisiae S288C	36-40
17270417-3	2007	Both AST and ALT activities could be measured sequentially by injecting the serum into a solution containing l-aspartate and alpha-ketoglutarate.	Aspartic Acid	109-120	solute carrier family 17 member 5	Homo sapiens	5-8
17438335-0	2007	Disruption of the aspartate to heme ester linkage in human myeloperoxidase: impact on ligand binding, redox chemistry, and interconversion of redox intermediates.	Aspartic Acid	18-27	myeloperoxidase	Homo sapiens	59-74
17532569-6	2007	However, CGRP produced statistically significant increases in the K+-evoked release of Asp and Glu, whereas AM failed to do so.	Aspartic Acid	87-90	calcitonin-related polypeptide alpha	Rattus norvegicus	9-13
17532569-8	2007	Present data suggest that the stimulatory effects of CGRP on the release of Asp and Glu were exerted by distinct types of CGRP receptors.	Aspartic Acid	76-79	calcitonin-related polypeptide alpha	Rattus norvegicus	53-57
17532569-8	2007	Present data suggest that the stimulatory effects of CGRP on the release of Asp and Glu were exerted by distinct types of CGRP receptors.	Aspartic Acid	76-79	calcitonin-related polypeptide alpha	Rattus norvegicus	122-126
17511476-11	2007	Substitution of RGS7 Glu-73 and Asp-74 for the corresponding Ser and Gly residues (ED/SG mutation) of RGS9 diminished the DEP-Gbeta5 interaction.	Aspartic Acid	32-35	regulator of G protein signaling 9	Homo sapiens	102-106
17511476-11	2007	Substitution of RGS7 Glu-73 and Asp-74 for the corresponding Ser and Gly residues (ED/SG mutation) of RGS9 diminished the DEP-Gbeta5 interaction.	Aspartic Acid	32-35	G protein subunit beta 5	Homo sapiens	126-132
17379327-6	2007	The specific cleavage sites for caspase-3 and caspase-9 were mapped to Asp(175) and Asp(208), respectively.	Aspartic Acid	71-74	caspase 3	Homo sapiens	32-41
17560372-6	2007	TORC1-dependent phosphorylation is required for Sch9 activity, and replacement of residues phosphorylated by TORC1 with Asp/Glu renders Sch9 activity TORC1 independent.	Aspartic Acid	120-123	CREB regulated transcription coactivator 1	Homo sapiens	0-5
17560372-6	2007	TORC1-dependent phosphorylation is required for Sch9 activity, and replacement of residues phosphorylated by TORC1 with Asp/Glu renders Sch9 activity TORC1 independent.	Aspartic Acid	120-123	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	48-52
17560372-6	2007	TORC1-dependent phosphorylation is required for Sch9 activity, and replacement of residues phosphorylated by TORC1 with Asp/Glu renders Sch9 activity TORC1 independent.	Aspartic Acid	120-123	CREB regulated transcription coactivator 1	Homo sapiens	109-114
17560372-6	2007	TORC1-dependent phosphorylation is required for Sch9 activity, and replacement of residues phosphorylated by TORC1 with Asp/Glu renders Sch9 activity TORC1 independent.	Aspartic Acid	120-123	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	136-140
17560372-6	2007	TORC1-dependent phosphorylation is required for Sch9 activity, and replacement of residues phosphorylated by TORC1 with Asp/Glu renders Sch9 activity TORC1 independent.	Aspartic Acid	120-123	CREB regulated transcription coactivator 1	Homo sapiens	109-114
17264232-12	2007	Methionine sulfoximine, an inhibitor of glutamine synthetase, blocked the glucose enhancement of AMM + Q-induced IR and associated changes in glutamine and aspartate but did not prevent the accumulation of glutamate.	Aspartic Acid	156-165	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	40-60
17293376-8	2007	The fibronectin-induced depression of contractility was blocked by the integrin antagonist Arg-Gly-Asp-Ser (RGDS) but not by its negative control Gly-Arg-Ala-Asp-Ser-Pro (GRADSP).	Aspartic Acid	99-102	fibronectin 1	Bos taurus	4-15
17379327-6	2007	The specific cleavage sites for caspase-3 and caspase-9 were mapped to Asp(175) and Asp(208), respectively.	Aspartic Acid	71-74	caspase 9	Homo sapiens	46-55
17379327-6	2007	The specific cleavage sites for caspase-3 and caspase-9 were mapped to Asp(175) and Asp(208), respectively.	Aspartic Acid	84-87	caspase 3	Homo sapiens	32-41
17379327-6	2007	The specific cleavage sites for caspase-3 and caspase-9 were mapped to Asp(175) and Asp(208), respectively.	Aspartic Acid	84-87	caspase 9	Homo sapiens	46-55
17428793-5	2007	The enzyme assumes an active conformation, with Ser-195, Glu-192, and Asp-189 oriented as in the Na+-bound fast form of human thrombin.	Aspartic Acid	70-73	coagulation factor II, thrombin	Homo sapiens	126-134
17315172-9	2007	Mutational analysis of exon 3 of the beta-catenin gene revealed that 4 of 26 cases (15.4%) contained point mutations (3 in codon 32, GAC [Asp] to GGC [Gly]; 1 in codon 42, ACA [Thr] to ATA [Ile]), and all these 4 cases showed beta-catenin accumulation immunohistochemically.	Aspartic Acid	138-141	catenin beta 1	Homo sapiens	37-49
17535962-4	2007	One of these, aspartate-444 of the neuronal glutamate transporter EAAC1, is conserved in glutamate transporters, but a serine residue occupies this position in DctA transporters.	Aspartic Acid	14-23	solute carrier family 1 member 1	Homo sapiens	66-71
17198754-12	2007	CONCLUSION: This study shows that intra-articular injection of COX-2 inhibitor parecoxib inhibits the ACLT-induced OA progression; it was accompanied by a reduction of glutamate and aspartate concentration in the ACLT joint dialysates.	Aspartic Acid	182-191	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	63-68
17498256-2	2007	In viral hepatitis, alcoholic liver disease and in primary biliary cirrhosis, the ratio of aspartate to alanine aminotransferase (AST/ALT) has been proven to be an indicator of liver cirrhosis.	Aspartic Acid	91-100	solute carrier family 17 member 5	Homo sapiens	130-133
17346885-8	2007	In morphine-tolerant rats, acute treatment with PKA inhibitor H89 and PKC inhibitor Go6805 attenuated morphine tolerance and the morphine-induced CSF glutamate and aspartate elevation, and induced trafficking of GLAST and GLT-1 from cytosol onto the cell surface.	Aspartic Acid	164-173	protein kinase C, gamma	Rattus norvegicus	70-73
17498272-3	2007	These substitutions result in a change of amino acid residues in HLA-DRB1*1376 at position 74 (Arg --&gt; Glu) and in -DRB*1465 at positions 47 (Tyr --&gt; Phe), 57 (Asp --&gt; Ser) and 74 (Glu --&gt; Ala).	Aspartic Acid	166-169	major histocompatibility complex, class II, DR beta 1	Homo sapiens	65-73
17173066-2	2007	When mutated on Asp 816 (corresponding to Asp 814 in the mouse), as preferentially found in human mastocytosis and acute myeloid leukemia, Kit became non-sensitive to imatinib mesylate (Gleevec).	Aspartic Acid	16-19	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	139-142
17880783-1	2007	OBJECTIVE: Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD, MIM#605814) is an inherited metabolic disease resulting from mutations of the gene SLC25A13, which encodes citrin, a liver-type mitochondrial aspartate-glutamate carrier.	Aspartic Acid	223-232	solute carrier family 25 member 13	Homo sapiens	164-172
17880783-1	2007	OBJECTIVE: Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD, MIM#605814) is an inherited metabolic disease resulting from mutations of the gene SLC25A13, which encodes citrin, a liver-type mitochondrial aspartate-glutamate carrier.	Aspartic Acid	223-232	solute carrier family 25 member 13	Homo sapiens	55-61
17173066-2	2007	When mutated on Asp 816 (corresponding to Asp 814 in the mouse), as preferentially found in human mastocytosis and acute myeloid leukemia, Kit became non-sensitive to imatinib mesylate (Gleevec).	Aspartic Acid	42-45	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	139-142
17317744-7	2007	The conductance has an anion-permeability sequence: NO3- approximately I- &gt; NO2- &gt; Br- &gt; Cl- &gt; SO4(2-) approximately HCO3- approximately gluconate- approximately aspartate- approximately cyclamate-.	Aspartic Acid	174-183	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Aspartic Acid	201-204	histidine triad nucleotide binding protein 1	Homo sapiens	92-97
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Aspartic Acid	201-204	histidine triad nucleotide binding protein 1	Homo sapiens	128-133
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Aspartic Acid	201-204	histidine triad nucleotide binding protein 1	Homo sapiens	135-141
17357163-2	2007	Nine alpha-MSH peptide analogues were constructed by exchanging the Trp9 residue in the alpha-MSH core with the natural or artificial amino acids Arg, Asp, Cys, Gly, Leu, Nal, d-Nal, Pro, or d-Trp.	Aspartic Acid	151-154	proopiomelanocortin	Homo sapiens	5-14
17439156-8	2007	This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS).	Aspartic Acid	97-100	neuronal differentiation 1	Homo sapiens	273-278
17477873-8	2007	RESULTS: Bioinformatic analysis of the Heterosigma akashiwo chloroplast genome sequence revealed the presence of a single two-component His-to-Asp (designated Tsg1/Trg1) pair in this stramenopile (golden-brown alga).	Aspartic Acid	143-146	ycf26	Heterosigma akashiwo	159-163
17475008-8	2007	Molecular docking experiments identified key residues in donor and acceptor recognition and provided insight into the catalytic mechanism of UGT glucuronidation, suggesting the human UGT1A1 residue histidine 39 (H39) as a general base and the residue aspartic acid 151 (D151) as an important electron-transfer helper.	Aspartic Acid	251-264	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	141-144
17337264-9	2007	Protonation of aspartic acid residues in detergent-solubilized TM2-3 also caused a significant increase in helicity.	Aspartic Acid	15-28	tropomyosin 3	Homo sapiens	63-68
17439156-8	2007	This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS).	Aspartic Acid	97-100	neuronal differentiation 1	Homo sapiens	303-308
17439156-8	2007	This is attributed to the fact that that low pH results in the protonation of the side chains of Asp, Glu, and His residues, which further disrupts the following four salt-bridge interactions stabilizing the alpha-beta interface of the native structure: Asp15-Arg53 (beta1-beta2), Glu21/20-Lys54 (helix-beta2), Asp40-Arg70 (helix-AS), and His43-Asp81 (beta2-AS).	Aspartic Acid	97-100	neuronal differentiation 1	Homo sapiens	303-308
17329498-4	2007	(p. 1222) capitalizes on the fluorescent properties of a recently introduced substrate for the dopamine (DA) transporter (DAT), termed 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP+), to illuminate a pertussis toxin-sensitive, extracellular signal-regulated kinase (ERK1/2)-dependent pathway by which presynaptic DA D(2) receptors regulate DATs.	Aspartic Acid	183-187	solute carrier family 6 member 3	Homo sapiens	122-125
17342483-10	2007	Based on sequence comparison and molecular modeling, mMCP-8 may prefer aspartic acid in substrate P1 position.	Aspartic Acid	71-84	mast cell protease 8	Mus musculus	53-59
17267664-4	2007	The present studies used the fluorescent DAT substrate, 4-[4-(diethylamino)-styryl]-N-methylpyridinium iodide (ASP(+)) with live cell imaging techniques to identify the role of two D(2)R-linked signaling pathways, extracellular signal-regulated kinases 1 and 2 (ERK1/2), and phosphoinositide 3 kinase (PI3K) in mediating D(2)R regulation of DAT.	Aspartic Acid	111-114	solute carrier family 6 member 3	Homo sapiens	41-44
17485849-5	2007	Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction.	Aspartic Acid	178-181	Lateral organ boundaries (LOB) domain family protein	Arabidopsis thaliana	25-28
17485849-5	2007	Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction.	Aspartic Acid	178-181	Lateral organ boundaries (LOB) domain family protein	Arabidopsis thaliana	29-32
17485849-5	2007	Then we found that among AS2/LOB family members, ASL9 is distinct from the others in that it is exclusively regulated by the plant hormone cytokinin in a manner dependent on His-Asp phosphorelay signal transduction.	Aspartic Acid	178-181	ASYMMETRIC LEAVES 2-like 9	Arabidopsis thaliana	49-53
17329498-4	2007	(p. 1222) capitalizes on the fluorescent properties of a recently introduced substrate for the dopamine (DA) transporter (DAT), termed 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP+), to illuminate a pertussis toxin-sensitive, extracellular signal-regulated kinase (ERK1/2)-dependent pathway by which presynaptic DA D(2) receptors regulate DATs.	Aspartic Acid	183-187	mitogen-activated protein kinase 3	Homo sapiens	272-278
17417949-5	2007	To increase cell survival, arginine-glycine-aspartic acid-serine (RGDS) was incorporated into gels using a novel mixed-mode thiol-ene reaction by synthesizing a cysteine-cysteine-arginine-glycine-aspartic acid-serine-cysteine-cysteine-glycine, N-terminus to C-terminus peptide sequence with pendant cysteine residues.	Aspartic Acid	44-57	ral guanine nucleotide dissociation stimulator	Homo sapiens	66-70
17445538-5	2007	Nucleotide 386 is the second base of codon 129, and A--&gt;G mutation (D129G) changed this codon from Asp(GAC) to Gly(GGC).	Aspartic Acid	102-105	gamma-glutamylcyclotransferase	Homo sapiens	118-121
17310063-10	2007	Although the T276A mutation had no significant effect on 5-HT transport or SERT protein expression, mutation to aspartate (T276D) increased the level of 5-HT uptake to that of cGMP-stimulated 5-HT uptake in wild-type SERT-expressing cells and was no longer sensitive to cGMP.	Aspartic Acid	112-121	solute carrier family 6 member 4	Rattus norvegicus	217-221
17310064-5	2007	Indeed, the loss of function resulting from the mutation of the conserved lysine residue into aspartate or glutamate in the TM3 of gamma-aminobutyric acid type B(2) can be partly rescued by mutating the conserved acidic residue of TM6 into either lysine or arginine.	Aspartic Acid	94-103	tropomyosin 3	Homo sapiens	124-127
17374638-0	2007	Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.	Aspartic Acid	59-62	fibrillin 1	Homo sapiens	17-28
17243099-3	2007	Single or double mutations of cys-70 and cys-88 to ser-70 and asp-88, respectively, markedly increased the amounts of FGF-2 protein in conditioned media and cell lysates, which may be due to glycosylation, particularly at the mutated asp-88 residue.	Aspartic Acid	62-65	fibroblast growth factor 2	Rattus norvegicus	118-123
17243099-3	2007	Single or double mutations of cys-70 and cys-88 to ser-70 and asp-88, respectively, markedly increased the amounts of FGF-2 protein in conditioned media and cell lysates, which may be due to glycosylation, particularly at the mutated asp-88 residue.	Aspartic Acid	234-237	fibroblast growth factor 2	Rattus norvegicus	118-123
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Aspartic Acid	141-144	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	129-132
17084038-2	2007	Approximately 20% of the CS patients have mutations in CSA, which encodes a 44 kDa tryptophane (Trp, W) and aspartic acid (Asp, D) amino acids (WD) repeat protein.	Aspartic Acid	108-121	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	55-58
17084038-2	2007	Approximately 20% of the CS patients have mutations in CSA, which encodes a 44 kDa tryptophane (Trp, W) and aspartic acid (Asp, D) amino acids (WD) repeat protein.	Aspartic Acid	123-126	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	55-58
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Aspartic Acid	141-144	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	133-136
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Aspartic Acid	141-144	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	249-252
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Aspartic Acid	141-144	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	253-256
17483803-3	2007	The results did show, however, some novel mutations at codon 83 of gyrA (Ser--&gt;Ile) and codon 64 of parC (Ala64--&gt;Cys, Ala64--&gt;Asp), which were related to fluroquinolone resistance.	Aspartic Acid	136-139	cullin 9	Homo sapiens	103-107
17429808-1	2007	RGDS (Arg-Gly-Asp-Ser) is immobilized on poly(L-lactic acid) (PLLA) with ozone oxidation and the addition of an intermediate reactant, acryl succinimide (ASI) to promote the grafting efficiency.	Aspartic Acid	14-17	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	0-4
17315164-4	2007	A functional polymorphism, an amino acid substitution of asparagine (Asp) for aspartic acid (Asn) at residue 327 (Asp(327)Asn) (reference sequence 6259), in the SHBG gene recently was identified and has been associated with an increased half-life and elevated blood levels of SHBG.	Aspartic Acid	78-91	sex hormone binding globulin	Homo sapiens	161-165
17315164-4	2007	A functional polymorphism, an amino acid substitution of asparagine (Asp) for aspartic acid (Asn) at residue 327 (Asp(327)Asn) (reference sequence 6259), in the SHBG gene recently was identified and has been associated with an increased half-life and elevated blood levels of SHBG.	Aspartic Acid	78-91	sex hormone binding globulin	Homo sapiens	276-280
17309748-6	2007	The TLR4 (ASP/299/Gly and Thr/399/Ile) gene polymorphisms were examined by melting point analysis.	Aspartic Acid	10-13	toll like receptor 4	Homo sapiens	4-8
17379857-3	2007	Here, the authors describe the development and pharmacological characterization of a nonhomogeneous fluorescent NET uptake assay using the compound 4-(4-dimethylaminostyryl)-N-methylpyridinium (ASP(+)).	Aspartic Acid	194-197	solute carrier family 6 member 2	Homo sapiens	112-115
17352478-0	2007	Role of aspartate-1 in Cu(II) binding to the amyloid-beta peptide of Alzheimer"s disease.	Aspartic Acid	8-17	amyloid beta precursor protein	Homo sapiens	45-57
17389249-0	2007	Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1.	Aspartic Acid	29-38	solute carrier family 1 member 1	Homo sapiens	146-151
17389019-2	2007	Nucleotide sequence analysis showed the presence of a new HLA-A*02 allele identical to HLA-A*02010101 except for a non-synonymous nucleotide exchange in exon 4 modifying codon 232 from GAG (Glu) to GAC (Asp).	Aspartic Acid	203-206	major histocompatibility complex, class I, A	Homo sapiens	58-63
17254025-3	2007	The latter reaction, catalyzed by aspartoacylase (ASPA), produces acetyl groups plus aspartate and has been proposed to occur in both soluble and membranous subfractions of white matter.	Aspartic Acid	85-94	aspartoacylase	Homo sapiens	34-48
17254025-3	2007	The latter reaction, catalyzed by aspartoacylase (ASPA), produces acetyl groups plus aspartate and has been proposed to occur in both soluble and membranous subfractions of white matter.	Aspartic Acid	85-94	aspartoacylase	Homo sapiens	50-54
17258903-2	2007	The missense mutation in exon 8 (GAC--&gt;AAC) causing the amino acid exchange Asp--&gt;Asn in codon 327 (D327N) correlates according to the published data with increased SHBG levels.	Aspartic Acid	79-82	glycine-N-acyltransferase	Homo sapiens	42-45
17258903-2	2007	The missense mutation in exon 8 (GAC--&gt;AAC) causing the amino acid exchange Asp--&gt;Asn in codon 327 (D327N) correlates according to the published data with increased SHBG levels.	Aspartic Acid	79-82	sex hormone binding globulin	Homo sapiens	171-175
17389019-2	2007	Nucleotide sequence analysis showed the presence of a new HLA-A*02 allele identical to HLA-A*02010101 except for a non-synonymous nucleotide exchange in exon 4 modifying codon 232 from GAG (Glu) to GAC (Asp).	Aspartic Acid	203-206	major histocompatibility complex, class I, A	Homo sapiens	87-92
17213189-0	2007	Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle.	Aspartic Acid	36-45	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	91-97
17237498-5	2007	Structural models for the ligand-free and ligand-bound states of BLT1 revealed an activation core formed around Asp-64, displaying multiple dynamic interactions with Asn-36, Ser-100, and Asn-281 and a triad of serines, Ser-276, Ser-277, and Ser-278.	Aspartic Acid	112-115	leukotriene B4 receptor	Homo sapiens	65-69
17276401-4	2007	Mutation of this amino acid into alanine or aspartic acid stabilized binding to MyD88, Tollip, and IRAK-4, allowing the definitive experimental proof, that all these interactions are mediated by the death domain of IRAK-1.	Aspartic Acid	44-57	MYD88 innate immune signal transduction adaptor	Homo sapiens	80-85
17276401-4	2007	Mutation of this amino acid into alanine or aspartic acid stabilized binding to MyD88, Tollip, and IRAK-4, allowing the definitive experimental proof, that all these interactions are mediated by the death domain of IRAK-1.	Aspartic Acid	44-57	toll interacting protein	Homo sapiens	87-93
17276401-4	2007	Mutation of this amino acid into alanine or aspartic acid stabilized binding to MyD88, Tollip, and IRAK-4, allowing the definitive experimental proof, that all these interactions are mediated by the death domain of IRAK-1.	Aspartic Acid	44-57	interleukin 1 receptor associated kinase 4	Homo sapiens	99-105
17276401-4	2007	Mutation of this amino acid into alanine or aspartic acid stabilized binding to MyD88, Tollip, and IRAK-4, allowing the definitive experimental proof, that all these interactions are mediated by the death domain of IRAK-1.	Aspartic Acid	44-57	interleukin 1 receptor associated kinase 1	Homo sapiens	215-221
17112341-7	2007	Changing Trp-479, Iso-490, Arg-505, Leu-511 or Asp-512 was predicted, based on previous studies, to affect affinity for Arf1-GTP.	Aspartic Acid	47-50	ADP ribosylation factor 1	Homo sapiens	120-124
17213189-0	2007	Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle.	Aspartic Acid	124-133	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	91-97
17213189-2	2007	The two mammalian AGCs, aralar and citrin, are members of the malate-aspartate NADH shuttle.	Aspartic Acid	69-78	solute carrier family 25 member 13	Homo sapiens	35-41
17244605-3	2007	In this report we used a polyreactive phosphospecific antibody (alpha-pDSQ) that recognizes a subset of phosphorylated Asp-Ser-Gln sequences to purify candidate ATM/ATR substrates.	Aspartic Acid	119-122	ATM serine/threonine kinase	Homo sapiens	161-164
17244605-3	2007	In this report we used a polyreactive phosphospecific antibody (alpha-pDSQ) that recognizes a subset of phosphorylated Asp-Ser-Gln sequences to purify candidate ATM/ATR substrates.	Aspartic Acid	119-122	ATR serine/threonine kinase	Homo sapiens	165-168
17204471-3	2007	By replacing this conserved aspartic acid residue with alanine, asparagine, glutamate, and arginine, we now show that this residue plays a crucial role in binding and signal transduction of NPY/PP at all YRs.	Aspartic Acid	28-41	neuropeptide Y	Homo sapiens	190-193
17204471-3	2007	By replacing this conserved aspartic acid residue with alanine, asparagine, glutamate, and arginine, we now show that this residue plays a crucial role in binding and signal transduction of NPY/PP at all YRs.	Aspartic Acid	28-41	pancreatic polypeptide	Homo sapiens	194-196
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Aspartic Acid	177-180	pancreatic polypeptide	Homo sapiens	225-227
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Aspartic Acid	177-180	neuropeptide Y	Homo sapiens	232-235
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Aspartic Acid	251-254	pancreatic polypeptide	Homo sapiens	225-227
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Aspartic Acid	251-254	neuropeptide Y	Homo sapiens	232-235
17360427-9	2007	Mimicking phosphorylation, substitution of the target serine residue by aspartate precludes PAR binding and stimulation of PARP-1.	Aspartic Acid	72-81	poly(ADP-ribose) polymerase 1	Homo sapiens	123-129
17211673-0	2007	Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa.	Aspartic Acid	25-28	hypoxanthine phosphoribosyltransferase	Saccharomyces cerevisiae S288C	47-52
17196983-0	2007	Linkage between the intramembrane H-bond network around aspartic acid 83 and the cytosolic environment of helix 8 in photoactivated rhodopsin.	Aspartic Acid	56-69	rhodopsin	Bos taurus	132-141
17040205-2	2007	The aim of the present study was to investigate whether the common C804A (resulting in a Thr(26)--&gt;Asp amino acid substitution) and A252G polymorphisms of the LTA gene and the C3279T polymorphism of the galectin-2 (LGALS2) gene, which affects LTA secretion, are associated with inflammatory parameters and cell adhesion molecules, and whether these polymorphisms are related to CHD in American women and men.	Aspartic Acid	102-105	lymphotoxin alpha	Homo sapiens	162-165
17204468-1	2007	Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization.	Aspartic Acid	8-17	C-X-C motif chemokine receptor 2	Rattus norvegicus	58-63
17204468-10	2007	Structure modeling of the 2ECL of the receptors also suggested that Asp(199) plays a critical role in stabilizing and modulating CXCR2 rapid internalization relative to CXCR1.	Aspartic Acid	68-71	C-X-C motif chemokine receptor 2	Rattus norvegicus	129-134
17341815-3	2007	We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.	Aspartic Acid	29-32	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	87-93
17211673-0	2007	Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa.	Aspartic Acid	25-28	Ccm1p	Saccharomyces cerevisiae S288C	57-62
17471159-4	2007	To complete the genotyping procedure of hAAT M variants, the exon-V Glu(376)/Asp(376) sequence variation was directly analyzed using a designer primer with a single-base substitution in its sequence.	Aspartic Acid	77-80	serpin family A member 1	Homo sapiens	40-44
17216280-2	2007	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repairs isomerised Asn and Asp residues in proteins.	Aspartic Acid	152-155	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	0-56
17216280-2	2007	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repairs isomerised Asn and Asp residues in proteins.	Aspartic Acid	152-155	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	58-62
17216280-2	2007	Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repairs isomerised Asn and Asp residues in proteins.	Aspartic Acid	152-155	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	85-90
17164427-3	2007	We evaluated fMLP-stimulated human neutrophil motility on peptides Arg-Gly-Asp-Ser (RGDS) and TMKIIPFNRTLIGG (P2), alone and in combination.	Aspartic Acid	75-78	formyl peptide receptor 1	Homo sapiens	13-17
17555083-5	2007	RESULTS: The frequencies of the Asp and Glu alleles of APE1 148 in our study population were 61% and 39%, respectively.	Aspartic Acid	32-35	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	55-59
17242372-0	2007	Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase.	Aspartic Acid	8-17	coproporphyrinogen oxidase	Homo sapiens	90-116
17179148-7	2007	The distinct specificities of human and mouse granzyme B highlight a previously unappreciated requirement for Asp(192) in the acquisition of catalytic activity upon cleavage of procaspase-3 at Asp(175).	Aspartic Acid	110-113	granzyme B	Mus musculus	46-56
17178732-4	2007	We show that integrin beta4 is cleaved by caspase-3 and -7 at a conserved Asp residue (Asp(1109)) in vitro and in epithelial cells undergoing apoptosis, resulting in the removal of most of its cytoplasmic tail.	Aspartic Acid	74-77	integrin subunit beta 4	Homo sapiens	13-27
17178732-4	2007	We show that integrin beta4 is cleaved by caspase-3 and -7 at a conserved Asp residue (Asp(1109)) in vitro and in epithelial cells undergoing apoptosis, resulting in the removal of most of its cytoplasmic tail.	Aspartic Acid	74-77	caspase 3	Homo sapiens	42-58
17178732-4	2007	We show that integrin beta4 is cleaved by caspase-3 and -7 at a conserved Asp residue (Asp(1109)) in vitro and in epithelial cells undergoing apoptosis, resulting in the removal of most of its cytoplasmic tail.	Aspartic Acid	87-90	integrin subunit beta 4	Homo sapiens	13-27
17178732-4	2007	We show that integrin beta4 is cleaved by caspase-3 and -7 at a conserved Asp residue (Asp(1109)) in vitro and in epithelial cells undergoing apoptosis, resulting in the removal of most of its cytoplasmic tail.	Aspartic Acid	87-90	caspase 3	Homo sapiens	42-58
17179148-7	2007	The distinct specificities of human and mouse granzyme B highlight a previously unappreciated requirement for Asp(192) in the acquisition of catalytic activity upon cleavage of procaspase-3 at Asp(175).	Aspartic Acid	193-196	granzyme B	Mus musculus	46-56
17112725-1	2007	BACE-1 is a flexible enzyme with experimentally determined motion in the flap region, the catalytic aspartates, and the 10s loop.	Aspartic Acid	100-110	beta-secretase 1	Homo sapiens	0-6
17364745-4	2007	It was found that 25 microM of the pan-isoform PKC inhibitor, chelerythrine, reduced [3H]D-aspartate uptake by 78%, 71%, and 68% in isolated retinas, mixed neuronal/glial cultures, and Muller cell-enriched cultures, respectively.	Aspartic Acid	91-100	protein kinase C, gamma	Rattus norvegicus	47-50
17369369-0	2007	T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue.	Aspartic Acid	113-122	cell division control 2	Arabidopsis thaliana	38-44
17110428-3	2007	Here, we demonstrate that addition of OPN before IL-1beta in freshly isolated rat islets improved their glucose stimulated insulin secretion dose-dependently and inhibited IL-1beta-induced NO production in an arginine-glycine-aspartate-dependent manner.	Aspartic Acid	226-235	secreted phosphoprotein 1	Rattus norvegicus	38-41
17110428-3	2007	Here, we demonstrate that addition of OPN before IL-1beta in freshly isolated rat islets improved their glucose stimulated insulin secretion dose-dependently and inhibited IL-1beta-induced NO production in an arginine-glycine-aspartate-dependent manner.	Aspartic Acid	226-235	interleukin 1 beta	Rattus norvegicus	172-180
17142003-8	2007	One of the 50 patients had an EGFR mutation in codon 719, resulting in an amino acid substitution from glycine to aspartic acid.	Aspartic Acid	114-127	epidermal growth factor receptor	Homo sapiens	30-34
17151221-1	2007	The most common single-nucleotide polymorphism (SNP) of the human mu-opioid receptor (hMOR) gene occurs at position 118 (A118G) and results in substitution of asparagine to aspartate at the N-terminus.	Aspartic Acid	173-182	opioid receptor mu 1	Homo sapiens	86-90
16979358-5	2007	Although differences exist in AAP sequence, there were three absolutely conserved amino acid residues in the predicted peptide, including an aspartic acid crucial for arginine-dependent regulation of arg-2 and CPA1.	Aspartic Acid	141-154	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	200-205
16979358-5	2007	Although differences exist in AAP sequence, there were three absolutely conserved amino acid residues in the predicted peptide, including an aspartic acid crucial for arginine-dependent regulation of arg-2 and CPA1.	Aspartic Acid	141-154	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	210-214
17242432-3	2007	Allele HLA-B*4402 (Asp at position 116) depends on tapasin for efficient peptide loading, whereas HLA-B*4405 (identical to B*4402 except for Tyr116) can efficiently load peptides in the absence of tapasin.	Aspartic Acid	19-22	major histocompatibility complex, class I, B	Homo sapiens	7-12
17202182-2	2007	The histidyl-aspartyl (His-Asp) phosphorelay mediates the signal from cytokinin receptors to type-B response regulators including ARR1, which transactivate cytokinin primary response genes.	Aspartic Acid	27-30	arrestin beta 1	Homo sapiens	130-134
17202182-8	2007	These results provide novel evidence indicating that the His-Asp phosphorelay is connected to diverse regulatory levels of cytokinin-responsive phenomena through ARR1 direct-target genes.	Aspartic Acid	61-64	arrestin beta 1	Homo sapiens	162-166
17242432-3	2007	Allele HLA-B*4402 (Asp at position 116) depends on tapasin for efficient peptide loading, whereas HLA-B*4405 (identical to B*4402 except for Tyr116) can efficiently load peptides in the absence of tapasin.	Aspartic Acid	19-22	TAP binding protein	Homo sapiens	51-58
17268153-4	2007	This review introduces our approaches that employ an Arg-Gly-Asp (RGD) fiber-mutant adenovirus vector encoding the chemokine or chemokine receptor gene in cancer immunotherapy.	Aspartic Acid	61-64	C-X-C motif chemokine receptor 4	Homo sapiens	128-146
17166537-7	2007	Crystal structure of the extracellular segment of integrin alphavbeta3 in complexing with an Arg-Gly-Asp ligand.	Aspartic Acid	101-104	integrin subunit alpha V	Homo sapiens	50-70
17183522-9	2007	However, the N-terminally blocked peptide of endothelin-1 (Ac-Asp-Ile-Ile-Trp) reacted in a very similar fashion to melatonin; this shows that tryptophan residue nitrosation could occur when it was exposed to peroxynitrite.	Aspartic Acid	62-65	endothelin 1	Homo sapiens	45-57
17244530-3	2007	We showed here that c-jun was transcriptionally repressed in response to osmotic stress via a truncated HDAC3 generated by caspase-7-dependent cleavage at aspartic acid 391.	Aspartic Acid	155-168	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
17244530-3	2007	We showed here that c-jun was transcriptionally repressed in response to osmotic stress via a truncated HDAC3 generated by caspase-7-dependent cleavage at aspartic acid 391.	Aspartic Acid	155-168	histone deacetylase 3	Homo sapiens	104-109
17244530-3	2007	We showed here that c-jun was transcriptionally repressed in response to osmotic stress via a truncated HDAC3 generated by caspase-7-dependent cleavage at aspartic acid 391.	Aspartic Acid	155-168	caspase 7	Homo sapiens	123-132
17114792-5	2007	Moreover, a "phosphomimetic" (aspartic acid) substitution at serine 517 enhances PKA-stimulated FA release over levels obtained with wild type Peri A.	Aspartic Acid	30-43	perilipin 1	Mus musculus	143-149
17071614-8	2007	In turn, nearly all mutations altering the CCR6-mediated chemotaxis are located at one area of the protein, defined by the N-terminal alpha-helical region (Asp(1)... Ser(8)) and a few topologically adjacent residues (Lys(22), Arg(29), and Lys(33)).	Aspartic Acid	156-159	C-C motif chemokine receptor 6	Homo sapiens	43-47
17209547-0	2007	Characterization of human UDP-glucose dehydrogenase reveals critical catalytic roles for lysine 220 and aspartate 280.	Aspartic Acid	104-113	UDP-glucose 6-dehydrogenase	Homo sapiens	26-51
17215371-3	2007	Based on quantum mechanics/molecular mechanics (QM/MM) calculations, the free energy for MeOH reduction of o-PQQ when MeOH is hydrogen bonded to Glu-171-CO(2)(-) and the crystal water (Wat1) is hydrogen bonded to Asp-297-CO(2)(-) is DeltaG++ = 11.7 kcal/mol, which is comparable with the experimental value of 8.5 kcal/mol.	Aspartic Acid	213-216	MTOR associated protein, LST8 homolog	Homo sapiens	185-189
17215371-5	2007	The Asp-297-CO(2)(-)...Wat1 complex is very stable.	Aspartic Acid	4-7	MTOR associated protein, LST8 homolog	Homo sapiens	23-27
17335661-2	2007	Recently, a single nucleotide polymorphism (G/T) at position 1057 in the KCNE4 gene, resulting in a glutamic acid (Glu, E)/aspartic acid (Asp, D) substitution at position 145 of the KCNE4 peptide, was found in our laboratory to be associated with idiopathic atrial fibrillation (atrial fibrillation more frequent with KCNE4 145D).	Aspartic Acid	123-136	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily E member 4	Cricetulus griseus	73-78
17335661-2	2007	Recently, a single nucleotide polymorphism (G/T) at position 1057 in the KCNE4 gene, resulting in a glutamic acid (Glu, E)/aspartic acid (Asp, D) substitution at position 145 of the KCNE4 peptide, was found in our laboratory to be associated with idiopathic atrial fibrillation (atrial fibrillation more frequent with KCNE4 145D).	Aspartic Acid	123-136	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily E member 4	Cricetulus griseus	182-187
17335661-2	2007	Recently, a single nucleotide polymorphism (G/T) at position 1057 in the KCNE4 gene, resulting in a glutamic acid (Glu, E)/aspartic acid (Asp, D) substitution at position 145 of the KCNE4 peptide, was found in our laboratory to be associated with idiopathic atrial fibrillation (atrial fibrillation more frequent with KCNE4 145D).	Aspartic Acid	123-136	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily E member 4	Cricetulus griseus	182-187
17335661-2	2007	Recently, a single nucleotide polymorphism (G/T) at position 1057 in the KCNE4 gene, resulting in a glutamic acid (Glu, E)/aspartic acid (Asp, D) substitution at position 145 of the KCNE4 peptide, was found in our laboratory to be associated with idiopathic atrial fibrillation (atrial fibrillation more frequent with KCNE4 145D).	Aspartic Acid	138-141	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily E member 4	Cricetulus griseus	73-78
17335661-2	2007	Recently, a single nucleotide polymorphism (G/T) at position 1057 in the KCNE4 gene, resulting in a glutamic acid (Glu, E)/aspartic acid (Asp, D) substitution at position 145 of the KCNE4 peptide, was found in our laboratory to be associated with idiopathic atrial fibrillation (atrial fibrillation more frequent with KCNE4 145D).	Aspartic Acid	138-141	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily E member 4	Cricetulus griseus	182-187
17335661-2	2007	Recently, a single nucleotide polymorphism (G/T) at position 1057 in the KCNE4 gene, resulting in a glutamic acid (Glu, E)/aspartic acid (Asp, D) substitution at position 145 of the KCNE4 peptide, was found in our laboratory to be associated with idiopathic atrial fibrillation (atrial fibrillation more frequent with KCNE4 145D).	Aspartic Acid	138-141	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily E member 4	Cricetulus griseus	182-187
17215371-8	2007	The Asp-297-CO(2)(-)...Wat1 of reactant complex does play a crucial role in catalysis.	Aspartic Acid	4-7	MTOR associated protein, LST8 homolog	Homo sapiens	23-27
17215371-9	2007	By QM/MM calculation DeltaG++ = 1.1 kcal/mol for Asp-297-CO(2)(-) general-base catalysis of Wat1 hydration of the immediate CH(2)==O product --&gt; CH(2)(OH)(2).	Aspartic Acid	49-52	MTOR associated protein, LST8 homolog	Homo sapiens	92-96
17085448-8	2007	Hence, the contact of HPrHis-15 to Asp-297 in CcpA is a determinant for HPr specific FBP and Glc-6-P stimulation.	Aspartic Acid	35-38	haptoglobin-related protein	Homo sapiens	22-25
17085448-8	2007	Hence, the contact of HPrHis-15 to Asp-297 in CcpA is a determinant for HPr specific FBP and Glc-6-P stimulation.	Aspartic Acid	35-38	fructose-bisphosphatase 1	Homo sapiens	85-88
17073851-5	2007	Recombinant human NR1/NR2A N-methyl-D-aspartate (NMDA), alpha(1)beta(2)gamma(2S)gamma-aminobutyric acid type A (GABA(A)) or alpha(1) glycine receptors, or GIRK1/GIRK2 channels were expressed in Xenopus laevis oocytes and the effects of GBP (0.1-1000 microM) on them were assessed using a two-electrode, voltage-clamp system.	Aspartic Acid	37-47	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	18-21
17192076-1	2007	[structure: see text] A solid-phase synthesis method for the preparation of novel beta3- and beta2-peptides derived from l-aspartic acid and beta-amino-l-alanine, respectively, is described.	Aspartic Acid	121-136	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	82-98
17073851-5	2007	Recombinant human NR1/NR2A N-methyl-D-aspartate (NMDA), alpha(1)beta(2)gamma(2S)gamma-aminobutyric acid type A (GABA(A)) or alpha(1) glycine receptors, or GIRK1/GIRK2 channels were expressed in Xenopus laevis oocytes and the effects of GBP (0.1-1000 microM) on them were assessed using a two-electrode, voltage-clamp system.	Aspartic Acid	37-47	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	22-26
17994383-0	2007	Alpha78(EF7)Asn--&gt;Asp is a posttranslational modification in Hb J-Singapore [alpha78(EF7)Asn--&gt;Asp;alpha79(EF8)Ala--&gt;Gly].	Aspartic Acid	21-24	FAM3 metabolism regulating signaling molecule D	Homo sapiens	8-11
16912056-3	2007	Preptin corresponds to Asp(69)-Leu(102) of pro-IGF-II.	Aspartic Acid	23-26	insulin like growth factor 2	Homo sapiens	0-7
16912056-3	2007	Preptin corresponds to Asp(69)-Leu(102) of pro-IGF-II.	Aspartic Acid	23-26	insulin like growth factor 2	Homo sapiens	47-53
17405923-12	2007	However, in the MB parvalbumin labels a subpopulation of glutamate/aspartate-containing neurons projecting mainly to the anterior thalamus.	Aspartic Acid	67-76	parvalbumin	Homo sapiens	19-30
16939419-4	2007	Mutation of the critical aspartic acid residue in the phosphorylation domain (DKTGTIT) blocked copper-induced redistribution of ATP7B from the TGN, whereas mutation of the phosphatase domain [TGE (Thr-Gly-Glu)] trapped ATP7B at cytosolic vesicular compartments.	Aspartic Acid	25-38	ATPase copper transporting beta	Homo sapiens	128-133
17994383-5	2007	In this report, we present electrospray mass spectrometry and DNA data to confirm the alpha78(EF7)Asn--&gt;Asp is indeed a posttranslational modification.	Aspartic Acid	107-110	FAM3 metabolism regulating signaling molecule D	Homo sapiens	94-97
16917073-9	2007	Seventy-five to eighty percent of ASP(+) uptake was inhibited by L-carnitine, an OCTN2-carried zwitterion.	Aspartic Acid	34-40	solute carrier family 22 member 5	Homo sapiens	81-86
16707531-2	2007	OBJECTIVE: To investigate the role of the functional polymorphism consisting of an aspartic acid (D) repeat polymorphism located in the ASPN gene in the susceptibility to and clinical outcome of rheumatoid arthritis.	Aspartic Acid	83-96	asporin	Homo sapiens	136-140
17041908-9	2007	We hypothesize from these results and previous receptor mutagenesis studies that Arg 6 recruitment of IL5Ralpha occurs through hydrogen bonding as well as charge-charge interactions with Asp 55 in site one of domain 1 of IL5Ralpha, and that this interaction is complemented by additional charged and hydrophobic interactions around the Asp 55 locus.	Aspartic Acid	336-339	interleukin 5 receptor subunit alpha	Homo sapiens	102-111
17994385-3	2007	Hb Hekinan [alpha27(B8)Glu--&gt;Asp, GAG--&gt;GAC (alpha2)] has not been found in Taiwan.	Aspartic Acid	32-35	NADH:ubiquinone oxidoreductase subunit A2	Homo sapiens	12-22
17994383-0	2007	Alpha78(EF7)Asn--&gt;Asp is a posttranslational modification in Hb J-Singapore [alpha78(EF7)Asn--&gt;Asp;alpha79(EF8)Ala--&gt;Gly].	Aspartic Acid	21-24	FAM3 metabolism regulating signaling molecule D	Homo sapiens	88-91
17994383-0	2007	Alpha78(EF7)Asn--&gt;Asp is a posttranslational modification in Hb J-Singapore [alpha78(EF7)Asn--&gt;Asp;alpha79(EF8)Ala--&gt;Gly].	Aspartic Acid	101-104	FAM3 metabolism regulating signaling molecule D	Homo sapiens	8-11
17994383-0	2007	Alpha78(EF7)Asn--&gt;Asp is a posttranslational modification in Hb J-Singapore [alpha78(EF7)Asn--&gt;Asp;alpha79(EF8)Ala--&gt;Gly].	Aspartic Acid	101-104	FAM3 metabolism regulating signaling molecule D	Homo sapiens	88-91
17478118-4	2007	Pyc1 and Pyc2 display different allosteric properties with respect to acetyl CoA activation and aspartate inhibition, with Pyc1 showing a higher degree of cooperativity than Pyc2, even in the absence of aspartate.	Aspartic Acid	96-105	pyruvate carboxylase 1	Saccharomyces cerevisiae S288C	0-4
17478118-4	2007	Pyc1 and Pyc2 display different allosteric properties with respect to acetyl CoA activation and aspartate inhibition, with Pyc1 showing a higher degree of cooperativity than Pyc2, even in the absence of aspartate.	Aspartic Acid	96-105	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	9-13
17478118-4	2007	Pyc1 and Pyc2 display different allosteric properties with respect to acetyl CoA activation and aspartate inhibition, with Pyc1 showing a higher degree of cooperativity than Pyc2, even in the absence of aspartate.	Aspartic Acid	96-105	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	174-178
17478118-4	2007	Pyc1 and Pyc2 display different allosteric properties with respect to acetyl CoA activation and aspartate inhibition, with Pyc1 showing a higher degree of cooperativity than Pyc2, even in the absence of aspartate.	Aspartic Acid	203-212	pyruvate carboxylase 1	Saccharomyces cerevisiae S288C	0-4
17478118-4	2007	Pyc1 and Pyc2 display different allosteric properties with respect to acetyl CoA activation and aspartate inhibition, with Pyc1 showing a higher degree of cooperativity than Pyc2, even in the absence of aspartate.	Aspartic Acid	203-212	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	9-13
17210763-3	2007	In addition, the administration of an ASARM (acidic serine-aspartate rich MEPE-associated motif) peptide derived from MEPE causes phosphaturia and inhibits bone mineralization in mice, suggesting that MEPE also plays a role in phosphate homeostasis.	Aspartic Acid	59-68	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	Mus musculus	74-78
16978906-0	2007	Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity.	Aspartic Acid	62-75	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	8-27
16978906-0	2007	Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity.	Aspartic Acid	62-75	transforming growth factor beta 1	Homo sapiens	99-131
16978906-2	2007	Arginine-glycine-aspartic acid-serine induces Transforming growth factor-beta1 transcription in human mesangial cells, but the molecular mechanisms involved have not been studied extensively.	Aspartic Acid	17-30	transforming growth factor beta 1	Homo sapiens	46-78
17616925-2	2007	In order to test if the same mutation would confer oncogenic properties to the homologous PDGF beta-receptor (Pdgfrb), the corresponding aspartic acid residue at position 849 of Pdgfrb was changed into valine (D849V) using a knock-in strategy.	Aspartic Acid	137-150	platelet derived growth factor receptor, beta polypeptide	Mus musculus	110-116
16978906-8	2007	Arginine-glycine-aspartic acid-serine stimulated Phosphoinositol-3 kinase activity, and Transforming growth factor-beta1 promoter activation was abrogated by the use of Phosphoinositol-3 kinase specific inhibitors.	Aspartic Acid	17-30	transforming growth factor beta 1	Homo sapiens	88-120
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Aspartic Acid	45-58	integrin linked kinase	Homo sapiens	76-98
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Aspartic Acid	45-58	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Aspartic Acid	45-58	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Aspartic Acid	45-58	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-221
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Aspartic Acid	45-58	transforming growth factor beta 1	Homo sapiens	234-266
17678956-8	2007	HMGB1-induced release of the stable glutamate analogue [(3)H]d-aspartate and endogenous glutamate form gliosomes, whereas nerve terminals were insensitive to the protein.	Aspartic Acid	63-72	high mobility group box 1	Homo sapiens	0-5
17210763-3	2007	In addition, the administration of an ASARM (acidic serine-aspartate rich MEPE-associated motif) peptide derived from MEPE causes phosphaturia and inhibits bone mineralization in mice, suggesting that MEPE also plays a role in phosphate homeostasis.	Aspartic Acid	59-68	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	Mus musculus	118-122
17210763-3	2007	In addition, the administration of an ASARM (acidic serine-aspartate rich MEPE-associated motif) peptide derived from MEPE causes phosphaturia and inhibits bone mineralization in mice, suggesting that MEPE also plays a role in phosphate homeostasis.	Aspartic Acid	59-68	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	Mus musculus	118-122
17603749-0	2007	Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population.	Aspartic Acid	19-32	asporin	Homo sapiens	60-67
17545223-6	2007	The results suggest that the higher level of free amino acids derived from the aspartate pathway in Oh545o2 endosperm results from a single amino acid change in the ASK2 enzyme that has pleiotropic effects on its activity.	Aspartic Acid	79-88	monofunctional aspartate kinase 2	Zea mays	165-169
17545225-5	2007	Mutation of the phosphorylatable aspartate to asparagine within the receiver domain creates a version of ARR4 that negatively affects photomorphogenesis.	Aspartic Acid	33-42	response regulator 4	Arabidopsis thaliana	105-109
17603749-1	2007	Recent genetic studies for osteoarthritis (OA) have been focused on ASPN, the gene encoding asporin, where aspartic acid (D)-repeat polymorphisms are associated with OA in several ethnic groups.	Aspartic Acid	107-120	asporin	Homo sapiens	68-72
18051365-9	2007	The critical residue Ser86 (Asp 96 position in bacteriorhodopsin: proton donor) for the pumping activity was replaced with Asp, but it did not change the proton pumping activity of Anabaena rhodopsin.	Aspartic Acid	28-31	rhodopsin	Homo sapiens	55-64
18051365-9	2007	The critical residue Ser86 (Asp 96 position in bacteriorhodopsin: proton donor) for the pumping activity was replaced with Asp, but it did not change the proton pumping activity of Anabaena rhodopsin.	Aspartic Acid	123-126	rhodopsin	Homo sapiens	55-64
16971689-5	2007	First, the rates of synaptic depression were slowed when cells contained SNAP-25 with phosphomimetic residues Glu or Asp.	Aspartic Acid	117-120	synaptosome associated protein 25	Homo sapiens	73-80
17603749-1	2007	Recent genetic studies for osteoarthritis (OA) have been focused on ASPN, the gene encoding asporin, where aspartic acid (D)-repeat polymorphisms are associated with OA in several ethnic groups.	Aspartic Acid	107-120	asporin	Homo sapiens	92-99
17259346-4	2007	This mutant form of APE1, termed ED, possesses two amino acid substitutions at active site residues Glu(96) (changed to Gln) and Asp(210) (changed to Asn).	Aspartic Acid	129-132	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	20-24
17313147-2	2007	The resulting mixed-mode CSP Chirasil-Val(gamma-Dex) 3 was found to have a greatly improved enantioselectivity toward proline and aspartic acid (as N-trifluoroacetyl ethyl or methyl esters) in comparison to the single-mode CSP 2.	Aspartic Acid	130-143	regulator of calcineurin 2	Homo sapiens	223-228
17516250-1	2007	Enterokinase (EC 3.4.21.9) is a serine proteinase of the intestinal brush border that exhibits specificity for the sequence (Asp)(4)-Lys and converts trypsinogen into its active form, trypsin.	Aspartic Acid	125-128	transmembrane serine protease 15	Bos taurus	0-12
17237342-6	2007	The two mammalian AGCs, aralar and citrin, are members of the malate-aspartate NADH shuttle, and citrin, the liver AGC, is also a member of the urea cycle.	Aspartic Acid	69-78	solute carrier family 25 member 13	Homo sapiens	35-41
17453414-3	2007	In this paper, we created four mutants in the human AE1 C-terminus by deletion of the residues Ala(891)-Phe(895), Asp(896)-Glu(899), Asp(902)-Glu(906) and Val(907)-Val(911), to investigate the role of these sequences in functional expression of AE1.	Aspartic Acid	114-117	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	52-55
17453414-3	2007	In this paper, we created four mutants in the human AE1 C-terminus by deletion of the residues Ala(891)-Phe(895), Asp(896)-Glu(899), Asp(902)-Glu(906) and Val(907)-Val(911), to investigate the role of these sequences in functional expression of AE1.	Aspartic Acid	133-136	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	52-55
17453414-5	2007	Western blotting showed that deletions of Ala(891)-Phe(895), Asp(896)-Glu(899), and Val(907)-Val(911) induced high expression of AE1, whereas loss of Asp(902)-Glu(906) results in stable low expression.	Aspartic Acid	61-64	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	129-132
17453414-5	2007	Western blotting showed that deletions of Ala(891)-Phe(895), Asp(896)-Glu(899), and Val(907)-Val(911) induced high expression of AE1, whereas loss of Asp(902)-Glu(906) results in stable low expression.	Aspartic Acid	150-153	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	129-132
17453414-7	2007	Ala(891)-Phe(895), Asp(902)-Glu(906) and Val(907)-Val(911) mutants exhibited lower levels of trafficking to the plasma membrane compared with WT AE1, while the Asp(896)-Glu(899) mutant was more highly expressed at the plasma membrane.	Aspartic Acid	19-22	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	145-148
16936707-2	2007	Owing to the reduced tendency of its molecules to form hexamers, the rapid-acting insulin analog insulin aspart (ASP-I) is more rapidly absorbed than RH-I after subcutaneous administration.	Aspartic Acid	113-116	insulin	Homo sapiens	82-89
16936707-2	2007	Owing to the reduced tendency of its molecules to form hexamers, the rapid-acting insulin analog insulin aspart (ASP-I) is more rapidly absorbed than RH-I after subcutaneous administration.	Aspartic Acid	113-116	insulin	Homo sapiens	97-104
17264120-2	2007	Within the C motif of hTERT is the Leu866-Val867-Asp868-Asp869 tetrapeptide that includes a catalytically essential aspartate dyad.	Aspartic Acid	116-125	telomerase reverse transcriptase	Homo sapiens	22-27
17279607-1	2007	A common procedure for identifying N-linked glycosylation sites involves tryptic digestion of the glycoprotein, followed by the conversion of glycosylated asparagine residues into (18)O-labeled aspartic acids by PNGase F digestion in (18)O water.	Aspartic Acid	194-208	N-glycanase 1	Homo sapiens	212-218
17068338-4	2006	Compared with other ABC transporters, the first nucleotide binding site contains non-consensus catalytic site residues, including Asp(668) in the Walker B region of TAP1 (in place of a highly conserved glutamic acid), and Gln(701) in the switch region of TAP1 (in place of a highly conserved histidine).	Aspartic Acid	130-133	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	165-169
17518591-0	2007	Monocytic U937 adhesion, tumor necrosis factor-alpha and interleukin-1 beta expression in response to gelatin-based networks grafted with arginine-glycine-aspartic acid and proline-histidine-serine-arginine-asparagine oligopeptides.	Aspartic Acid	155-168	interleukin 1 beta	Homo sapiens	57-75
17068338-4	2006	Compared with other ABC transporters, the first nucleotide binding site contains non-consensus catalytic site residues, including Asp(668) in the Walker B region of TAP1 (in place of a highly conserved glutamic acid), and Gln(701) in the switch region of TAP1 (in place of a highly conserved histidine).	Aspartic Acid	130-133	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	255-259
17068338-7	2006	Alterations of TAP1 Asp(668) alone or in combination with TAP1 Gln(701) had only small effects on TAP activity.	Aspartic Acid	20-23	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	15-19
17068338-7	2006	Alterations of TAP1 Asp(668) alone or in combination with TAP1 Gln(701) had only small effects on TAP activity.	Aspartic Acid	20-23	filamin B	Homo sapiens	15-18
17068338-8	2006	Thus, the naturally occurring Asp(668) and Gln(701) alterations of TAP1 are likely to contribute to attenuated catalytic activity at the first nucleotide binding site (the TAP1 site) of TAP complexes.	Aspartic Acid	30-33	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	67-71
17068338-8	2006	Thus, the naturally occurring Asp(668) and Gln(701) alterations of TAP1 are likely to contribute to attenuated catalytic activity at the first nucleotide binding site (the TAP1 site) of TAP complexes.	Aspartic Acid	30-33	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	172-176
17068338-8	2006	Thus, the naturally occurring Asp(668) and Gln(701) alterations of TAP1 are likely to contribute to attenuated catalytic activity at the first nucleotide binding site (the TAP1 site) of TAP complexes.	Aspartic Acid	30-33	filamin B	Homo sapiens	67-70
17046814-6	2006	The in vivo DSPP cleavage sites were on the N-terminal sides of Thr(200), Ser(330), Val(353), Leu(360), Ile(362), Ser(377), Ser(408), and Asp(458).	Aspartic Acid	138-141	dentin sialophosphoprotein	Homo sapiens	12-16
17176057-6	2006	We studied mutants of Leptosphaeria rhodopsin in which this aspartic acid was replaced with Glu or Asn using spectroscopy in the infrared and visible ranges.	Aspartic Acid	60-73	rhodopsin	Homo sapiens	36-45
17176052-0	2006	Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis.	Aspartic Acid	125-134	peroxiredoxin 1	Homo sapiens	142-147
17015450-2	2006	Asp(78) and Glu(83) are fully conserved in GTP-PEP-CKs.	Aspartic Acid	0-3	progestagen associated endometrial protein	Homo sapiens	47-50
17015450-3	2006	The human PEPCK crystal structure suggests that Asp(78) influences Tyr(220); Tyr(220) helps to position bound PEP, and Glu(83) interacts with Arg(81).	Aspartic Acid	48-51	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	10-15
17015450-3	2006	The human PEPCK crystal structure suggests that Asp(78) influences Tyr(220); Tyr(220) helps to position bound PEP, and Glu(83) interacts with Arg(81).	Aspartic Acid	48-51	progestagen associated endometrial protein	Homo sapiens	10-13
17015450-19	2006	In contrast, substitutions at Asp(75), a site far from bound PEP, brought subtle effects, lowering oxaloacetate formation rate but enhancing PEP formation rate.	Aspartic Acid	30-33	progestagen associated endometrial protein	Homo sapiens	61-64
17015450-19	2006	In contrast, substitutions at Asp(75), a site far from bound PEP, brought subtle effects, lowering oxaloacetate formation rate but enhancing PEP formation rate.	Aspartic Acid	30-33	progestagen associated endometrial protein	Homo sapiens	141-144
17015450-20	2006	It is likely that Asp(75) substitutions affected PEP-Mn(2+) interaction by changing the positions of Asp(78), Arg(81), and Glu(83), which translated to differential effects on two directions.	Aspartic Acid	18-21	progestagen associated endometrial protein	Homo sapiens	49-52
16886222-2	2006	Starting with a foundation consisting of an environmentally responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel, we incorporated matrix metalloproteinase-13 (MMP-13) degradable crosslinkers and peptides containing integrin-binding domains (i.e., Arg-Gly-Asp) to create a biomimetic matrix designed to encourage osteoblast migration and proliferation.	Aspartic Acid	266-269	matrix metallopeptidase 13	Rattus norvegicus	170-176
17156427-1	2006	BACKGROUND: Aspartyl (asparaginyl)-beta-hydroxylase (AAH) hydroxylates Asp and Asn residues within EGF-like domains of Notch and Jagged, which mediate cell motility and differentiation.	Aspartic Acid	12-15	aspartate beta-hydroxylase	Homo sapiens	53-56
17142774-3	2006	Proteolytically active ASP induced VL mainly in a bradykinin (BK) B(2) receptor-, and partially in a histamine-H(1) receptor-dependent manner in guinea pig skin.	Aspartic Acid	23-26	histamine H1 receptor	Cavia porcellus	101-124
17142774-5	2006	ASP produced VL activity from human plasma apparently through kallikrein/kinin system activation, suggesting that ASP can generate kinin in humans.	Aspartic Acid	0-3	kallikrein related peptidase 4	Homo sapiens	62-72
17142774-6	2006	Consistent with the finding that a major part of the ASP-induced VL was reduced by a potent kallikrein inhibitor, soybean trypsin inhibitor that does not affect ASP enzymatic activity, ASP activated prekallikrein but not factor XII to generate kallikrein in a dose- and incubation time-dependent manner.	Aspartic Acid	53-56	kallikrein related peptidase 4	Homo sapiens	92-102
17142774-6	2006	Consistent with the finding that a major part of the ASP-induced VL was reduced by a potent kallikrein inhibitor, soybean trypsin inhibitor that does not affect ASP enzymatic activity, ASP activated prekallikrein but not factor XII to generate kallikrein in a dose- and incubation time-dependent manner.	Aspartic Acid	53-56	kallikrein related peptidase 4	Homo sapiens	202-212
16901987-7	2006	The nucleotide sequence of AQP5 cDNA from low producers indicated the existence of a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the third transmembrane domain, but no alteration was detected in the Kozak area.	Aspartic Acid	166-169	aquaporin 5	Rattus norvegicus	27-31
17167410-1	2006	PURPOSE: The purpose of our study was to determine whether arrestin residues previously predicted by computational modeling to interact with an aspartic acid substituted rhodopsin tail are actually involved in interactions with phospho-residues on the rhodopsin cytoplasmic tail.	Aspartic Acid	144-157	rhodopsin	Homo sapiens	170-179
17160946-2	2006	The responsive gene of citrin deficiency, SLC25A13, locates on chromosome 7q21.3 and encodes citrin as a liver-type mitochondrial aspartate/glutamate carrier (AGC).	Aspartic Acid	130-139	solute carrier family 25 member 13	Homo sapiens	42-50
17099247-2	2006	In this article, the authors describe the use of a fluorescent substrate of the transporter (4-(4-(dimethylamino)-styrl)-N-methylpyridinium, ASP) to develop a microplate-based high-throughput screen for hSERT function.	Aspartic Acid	141-144	solute carrier family 6 member 4	Homo sapiens	203-208
17064933-3	2006	The expression plasmid contained the GnRH3-hinge-MVP construct ligated to its fusion partner (AnsB-C) via an unique acid labile Asp-Pro linker.	Aspartic Acid	128-131	gonadotropin releasing hormone 1	Homo sapiens	37-42
17135417-3	2006	Using knock-in mice that carry aspartate-to-asparagine substitutions in a Ca2+-binding site of synaptotagmin-1 (the D232N or D238N substitutions), we now show that the D232N mutation dramatically increases Ca2+-dependent SNARE complex binding by native synaptotagmin-1, but leaves phospholipid binding unchanged.	Aspartic Acid	31-40	synaptotagmin I	Mus musculus	95-110
16982605-6	2006	Substitution of both residues with the phosphoserine mimetic, aspartic acid, produced a mutant PACT that, unlike the wild-type protein, caused PKR activation and apoptosis, even in unstressed cells.	Aspartic Acid	62-75	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	95-99
16982605-6	2006	Substitution of both residues with the phosphoserine mimetic, aspartic acid, produced a mutant PACT that, unlike the wild-type protein, caused PKR activation and apoptosis, even in unstressed cells.	Aspartic Acid	62-75	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	143-146
16966328-1	2006	The crystal structure of the neuronal nitric-oxide synthase (nNOS) NADPH/FAD binding domain indicated that Ser-1176 is within hydrogen bonding distance of Asp-1393 and the O4 atom of FAD and is also near the N5 atom of FAD (3.7 A).	Aspartic Acid	155-158	nitric oxide synthase 1	Homo sapiens	29-59
16966328-1	2006	The crystal structure of the neuronal nitric-oxide synthase (nNOS) NADPH/FAD binding domain indicated that Ser-1176 is within hydrogen bonding distance of Asp-1393 and the O4 atom of FAD and is also near the N5 atom of FAD (3.7 A).	Aspartic Acid	155-158	nitric oxide synthase 1	Homo sapiens	61-65
16966328-9	2006	These data presented here suggest that hydrogen bonding of the hydroxyl group of serine or threonine with the isoalloxazine ring of FAD and with the amino acids in its immediate milieu, particularly nNOS Asp-1393, affects the redox potentials of various flavin states, influencing the rate of electron transfer.	Aspartic Acid	204-207	nitric oxide synthase 1	Homo sapiens	199-203
17045597-1	2006	A new sensitive assay for aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities in biofluids was developed, based on the separation and detection of alanine, glutamate, and aspartate using capillary electrophoresis (CE) with electrochemiluminescence (ECL) detection.	Aspartic Acid	26-35	solute carrier family 17 member 5	Homo sapiens	54-57
17045926-7	2006	Since caspase-3 cleaves PKCdelta between proline and aspartate residues at the cleavage site 324DIPD327 to activate the kinase, we developed an irreversible and competitive peptide inhibitor, Z-Asp(OMe)-Ile-Pro-Asp(OMe)-FMK (z-DIPD-fmk), to mimic the caspase-3 cleavage site of PKCdelta and tested its efficacy against oxidative stress-induced cell death in PD models.	Aspartic Acid	53-62	caspase 3	Mus musculus	6-15
17045926-7	2006	Since caspase-3 cleaves PKCdelta between proline and aspartate residues at the cleavage site 324DIPD327 to activate the kinase, we developed an irreversible and competitive peptide inhibitor, Z-Asp(OMe)-Ile-Pro-Asp(OMe)-FMK (z-DIPD-fmk), to mimic the caspase-3 cleavage site of PKCdelta and tested its efficacy against oxidative stress-induced cell death in PD models.	Aspartic Acid	53-62	protein kinase C, delta	Mus musculus	24-32
17160946-2	2006	The responsive gene of citrin deficiency, SLC25A13, locates on chromosome 7q21.3 and encodes citrin as a liver-type mitochondrial aspartate/glutamate carrier (AGC).	Aspartic Acid	130-139	solute carrier family 25 member 13	Homo sapiens	23-29
17041897-4	2006	The mutation leads to substitution of the neutral amino acid asparagine (N) by the negatively charged aspartic acid (D) at amino acid number 14, a position that is conserved among Cx26 of different organisms and among many other connexin isoforms.	Aspartic Acid	102-115	gap junction protein beta 2 L homeolog	Xenopus laevis	180-184
16829221-7	2006	The extent of aspartic acid isomerization of type I collagen C telopeptide (CTX) was evaluated by ELISA of native (alpha CTX) and isomerized (beta CTX) forms.	Aspartic Acid	14-27	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	45-80
16829221-7	2006	The extent of aspartic acid isomerization of type I collagen C telopeptide (CTX) was evaluated by ELISA of native (alpha CTX) and isomerized (beta CTX) forms.	Aspartic Acid	14-27	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	76-79
17065478-4	2006	This mutation deleted a highly conserved aspartic acid residue in the third of seven WD domains in GNB3.	Aspartic Acid	41-54	G protein subunit beta 3	Gallus gallus	99-103
17074833-6	2006	Biochemical and mutational analysis revealed that the DAB2 cell-adhesion Arg-Gly-Asp (RGD) motif (amino acid residues 64-66) and the alphaIIb-integrin-fibrinogen-binding region (amino acid residues 171-464) are important for the DAB2-platelet interactions.	Aspartic Acid	81-84	DAB adaptor protein 2	Homo sapiens	54-58
16926147-9	2006	Mass spectrometric analysis suggested that the cleavage sites of Npr599 and InhA are the Asp(39)-Asp(40) and Gly(48)-Thr(49) bonds, respectively.	Aspartic Acid	89-92	inhibin alpha	Mus musculus	76-80
16911580-3	2006	HMGB1 induced release of the glutamate analogue [(3)H]d-aspartate form gliosomes in a concentration-dependent manner, whereas nerve terminals were insensitive to the protein.	Aspartic Acid	56-65	high mobility group box 1	Mus musculus	0-5
16814865-3	2006	However, a number of other serine acylhydrolases (patatin, Group VI PLA2s, Pseudomonas aeruginosa ExoU and NTE) contain the Ser/Asp catalytic dyad characteristic of Group IV PLA2s, and recent structural analysis of patatin has confirmed its structural similarity to cPLA2alpha.	Aspartic Acid	128-131	phospholipase A2 group IIA	Homo sapiens	68-73
16814865-3	2006	However, a number of other serine acylhydrolases (patatin, Group VI PLA2s, Pseudomonas aeruginosa ExoU and NTE) contain the Ser/Asp catalytic dyad characteristic of Group IV PLA2s, and recent structural analysis of patatin has confirmed its structural similarity to cPLA2alpha.	Aspartic Acid	128-131	phospholipase A2 group IIA	Homo sapiens	174-179
16814865-3	2006	However, a number of other serine acylhydrolases (patatin, Group VI PLA2s, Pseudomonas aeruginosa ExoU and NTE) contain the Ser/Asp catalytic dyad characteristic of Group IV PLA2s, and recent structural analysis of patatin has confirmed its structural similarity to cPLA2alpha.	Aspartic Acid	128-131	phospholipase A2 group IVA	Homo sapiens	266-276
16950786-4	2006	In particular, the conversion of an aspartic acid to an isoaspartic acid within the melanoma antigen tyrosinase-related protein (TRP)-2 peptide-(181-188) makes the otherwise immunologically ignored TRP-2 antigen immunogenic.	Aspartic Acid	36-49	tRNA proline 2	Mus musculus	198-203
16978865-5	2006	Replacement of the conserved glutamate in position 106 of the first TM domain of CRACM1 with glutamine (E106Q) acts as a dominant-negative protein, and substitution with aspartate (E106D) enhances Na(+), Ba(2+), and Sr(2+) permeation relative to Ca(2+).	Aspartic Acid	170-179	ORAI calcium release-activated calcium modulator 1	Homo sapiens	81-87
16957054-2	2006	Here, we describe a novel tryptophan-aspartic acid (WD) repeat (WDR) containing IFT protein from Caenorhabditis elegans, DYF-2, that plays a critical role in maintaining the structural and functional integrity of the IFT machinery.	Aspartic Acid	37-50	WD repeat-containing protein dyf-2	Caenorhabditis elegans	121-126
17028591-2	2006	Specifically, Rag complexes form DNA hairpins through direct transesterification, using a catalytic Asp-Asp-Glu (DDE) triad in Rag1.	Aspartic Acid	100-103	recombination activating 1	Homo sapiens	127-131
17028591-2	2006	Specifically, Rag complexes form DNA hairpins through direct transesterification, using a catalytic Asp-Asp-Glu (DDE) triad in Rag1.	Aspartic Acid	104-107	recombination activating 1	Homo sapiens	127-131
16926147-9	2006	Mass spectrometric analysis suggested that the cleavage sites of Npr599 and InhA are the Asp(39)-Asp(40) and Gly(48)-Thr(49) bonds, respectively.	Aspartic Acid	97-100	inhibin alpha	Mus musculus	76-80
16847063-5	2006	Small amounts of Ser-129 phosphorylated and Asp-119-truncated alpha-synuclein are present in the soluble fraction of both normal and disease brains, suggesting that these Lewy body-associated forms are produced during normal metabolism of alpha-synuclein.	Aspartic Acid	44-47	synuclein alpha	Homo sapiens	62-77
16873405-6	2006	Mutational studies showed that absence of the pH-independent current in Na(V)1.5 could be ascribed to the cysteine in domain I, just above the selectivity filter aspartate (Cys373).	Aspartic Acid	162-171	immunoglobulin lambda variable 2-18	Homo sapiens	72-80
17015730-3	2006	This epitope is presented in two isoforms containing either Asn or Asp, depending on the structure of the tyrosinase precursor.	Aspartic Acid	67-70	tyrosinase	Homo sapiens	106-116
16899466-8	2006	In support of these results, COS cell transfection experiments show that phosphomimetic mutation Thr-35 --&gt; Asp or induced cellular PKC caused increased CYP1A1 targeting to MT and correspondingly lower levels to the endoplasmic reticulum.	Aspartic Acid	111-114	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	156-162
16984999-7	2006	However, EXPB1 lacks a second aspartate that serves as the catalytic base required for hydrolytic activity in GH45 enzymes.	Aspartic Acid	30-39	expansin-B1	Zea mays	9-14
16893894-10	2006	Additionally, mutation of an amino acid residue (TLR2 Asp-730) in Region II also resulted in decreased activity in agreement with our model, providing new insights into the structure-function relationship of TLR2/1 TIR domains.	Aspartic Acid	54-57	toll like receptor 2	Homo sapiens	49-53
16893894-10	2006	Additionally, mutation of an amino acid residue (TLR2 Asp-730) in Region II also resulted in decreased activity in agreement with our model, providing new insights into the structure-function relationship of TLR2/1 TIR domains.	Aspartic Acid	54-57	toll like receptor 2	Homo sapiens	208-214
16973824-4	2006	The introduction of a negatively charged residue at position 81, by converting serine to aspartate, mimicked the PKC phosphorylation effect on alpha(1D) Ca(2+) channel.	Aspartic Acid	89-98	proline rich transmembrane protein 2	Homo sapiens	113-116
17055361-6	2006	The novel allele A*2630 is identical to A*2603 at exon 2 and exon 3 except for a nonsynonymous change at codon 90 (GAC--&gt;GCC), changed from Aspartic acid to Alanine.	Aspartic Acid	143-156	guanylate cyclase 2C	Homo sapiens	124-127
16955215-5	2006	The screening in the present paper of two polymorphisms in MT1a gene has revealed for the first time that the polymorphism corresponding to a A/C (Asp/Thr) transition at 647 nt position in the Mt1a coding region is the more involved in the longevity, at least in old women, rather than the other corresponding to A/G (Lys/Arg) transition at 1,245 nt position.	Aspartic Acid	147-150	metallothionein 1A	Homo sapiens	59-63
16955215-5	2006	The screening in the present paper of two polymorphisms in MT1a gene has revealed for the first time that the polymorphism corresponding to a A/C (Asp/Thr) transition at 647 nt position in the Mt1a coding region is the more involved in the longevity, at least in old women, rather than the other corresponding to A/G (Lys/Arg) transition at 1,245 nt position.	Aspartic Acid	147-150	metallothionein 1A	Homo sapiens	193-197
16955215-6	2006	Concomitantly, for the +647 MT1a polymorphism, old and very old female with Asp/Asp genotype (called C-carriers) display higher zinc release by MT (detected by Zinpyr-1 fluorescent probe in presence of NO donor), low MT levels and reduced IL-6 plasma concentrations, suggesting its involvement in longevity and in lower inflammatory status.	Aspartic Acid	76-79	metallothionein 1A	Homo sapiens	28-32
16955215-6	2006	Concomitantly, for the +647 MT1a polymorphism, old and very old female with Asp/Asp genotype (called C-carriers) display higher zinc release by MT (detected by Zinpyr-1 fluorescent probe in presence of NO donor), low MT levels and reduced IL-6 plasma concentrations, suggesting its involvement in longevity and in lower inflammatory status.	Aspartic Acid	76-79	interleukin 6	Homo sapiens	239-243
16955215-6	2006	Concomitantly, for the +647 MT1a polymorphism, old and very old female with Asp/Asp genotype (called C-carriers) display higher zinc release by MT (detected by Zinpyr-1 fluorescent probe in presence of NO donor), low MT levels and reduced IL-6 plasma concentrations, suggesting its involvement in longevity and in lower inflammatory status.	Aspartic Acid	80-83	metallothionein 1A	Homo sapiens	28-32
16955215-6	2006	Concomitantly, for the +647 MT1a polymorphism, old and very old female with Asp/Asp genotype (called C-carriers) display higher zinc release by MT (detected by Zinpyr-1 fluorescent probe in presence of NO donor), low MT levels and reduced IL-6 plasma concentrations, suggesting its involvement in longevity and in lower inflammatory status.	Aspartic Acid	80-83	interleukin 6	Homo sapiens	239-243
16838152-0	2006	Peptide-cleaving catalyst selective for melanin-concentrating hormone: Oxidative decarboxylation of N-terminal aspartate catalyzed by Co(III)cyclen.	Aspartic Acid	111-120	pro-melanin concentrating hormone	Homo sapiens	40-69
16838152-1	2006	To provide a firm basis for the new paradigm of drug discovery based on catalysts for oxidative cleavage of N-terminal aspartate (Asp) residues of oligopeptides, oligopeptide-cleaving catalysts were searched by using melanin-concentrating hormone (MCH) as the substrate.	Aspartic Acid	130-133	pro-melanin concentrating hormone	Homo sapiens	217-246
16838152-1	2006	To provide a firm basis for the new paradigm of drug discovery based on catalysts for oxidative cleavage of N-terminal aspartate (Asp) residues of oligopeptides, oligopeptide-cleaving catalysts were searched by using melanin-concentrating hormone (MCH) as the substrate.	Aspartic Acid	130-133	pro-melanin concentrating hormone	Homo sapiens	248-251
16838152-5	2006	On incubation with the catalyst, the N-terminal Asp residue of MCH was converted to the pyruvate residue by oxidative decarboxylation.	Aspartic Acid	48-51	pro-melanin concentrating hormone	Homo sapiens	63-66
16982895-6	2006	A central cluster of hydrophilic CD1d residues (Asp(153), Thr(156), Ser(76), Arg(79)) interacts with the phosphate, inositol, and alpha1-alpha6-linked mannose of the headgroup, whereas additional specificity for the alpha1- and alpha2-linked mannose is conferred by Thr(159).	Aspartic Acid	48-51	CD1d1 antigen	Mus musculus	33-37
16899024-5	2006	The SNP in exon 9 results in Asp--&gt;Ala substitution in the proteolytic cleavage site of IL-6Ralpha.	Aspartic Acid	29-32	interleukin 6 receptor	Homo sapiens	91-101
16982895-6	2006	A central cluster of hydrophilic CD1d residues (Asp(153), Thr(156), Ser(76), Arg(79)) interacts with the phosphate, inositol, and alpha1-alpha6-linked mannose of the headgroup, whereas additional specificity for the alpha1- and alpha2-linked mannose is conferred by Thr(159).	Aspartic Acid	48-51	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	130-143
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Aspartic Acid	107-110	defensin, alpha, 4	Mus musculus	135-139
16831195-10	2006	The preference for L-aspartate in the presence of lithium was also observed when electrogenic transport of radioactive substrates was monitored in EAAC1-containing proteoliposomes.	Aspartic Acid	19-30	solute carrier family 1 member 1	Homo sapiens	147-152
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Aspartic Acid	107-110	defensin, alpha, 4	Mus musculus	135-139
16861223-7	2006	X-ray crystallography of the complex of CD38 with one of its substrates, NMN, showed that the nicotinamide moiety was in close contact with Glu(146) at 3.27 A and Asp(155) at 2.52 A.	Aspartic Acid	163-166	CD38 molecule	Homo sapiens	40-44
16861223-12	2006	Synthesis of NAADP catalyzed by CD38 is known to have strong preference for acidic pH, suggesting that Glu(146) and Asp(155) are also critical determinants.	Aspartic Acid	116-119	CD38 molecule	Homo sapiens	32-36
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Aspartic Acid	107-110	defensin, alpha, 4	Mus musculus	135-139
16861237-6	2006	From the results of binding assays, a region containing the Glu/Asp-rich domain within LANA, and a central region including the second paired amphipathic helix within Daxx contributed to the interaction.	Aspartic Acid	64-67	LANA	Human gammaherpesvirus 8	87-91
16981702-0	2006	Aspartic acid 405 contributes to the substrate specificity of aminopeptidase B.	Aspartic Acid	0-13	arginyl aminopeptidase	Rattus norvegicus	62-78
16861237-6	2006	From the results of binding assays, a region containing the Glu/Asp-rich domain within LANA, and a central region including the second paired amphipathic helix within Daxx contributed to the interaction.	Aspartic Acid	64-67	death domain associated protein	Homo sapiens	167-171
16756512-10	2006	We also present evidence that histidine and aspartic acid residues in the Lag motif are essential for the function of Lag1p in vivo.	Aspartic Acid	44-57	sphingosine N-acyltransferase LAG1	Saccharomyces cerevisiae S288C	118-123
16870620-4	2006	In the neuronal glutamate transporter EAAC1, the equivalent residues are asparagine 366 and aspartate 368.	Aspartic Acid	92-101	solute carrier family 1 member 1	Homo sapiens	38-43
16690964-5	2006	In E9.5 yolk sacs derived from recombinant mice expressing kinase-active PDGFR-beta with an aspartic acid to asparagine (D894N) replacement in the kinase activating loop and from mice with ubiquitous expression of PDGF-BB driven by the Rosa26 locus, the number of CD41-expressing early hematopoietic cells decreased by 36% and 34%, respectively, compared with staged wild-type littermates.	Aspartic Acid	92-105	platelet derived growth factor receptor, beta polypeptide	Mus musculus	73-83
16857668-5	2006	A second region, centered on an aspartic acid residue in leucine-rich repeat 17, is also required for TLR8 function.	Aspartic Acid	32-45	toll like receptor 8	Homo sapiens	102-106
16864587-6	2006	Instead of a glutamate, proposed to act as a general base, TAP1 contains an aspartate and a glutamine instead of the conserved histidine, which has been suggested to act as the linchpin.	Aspartic Acid	76-85	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	59-63
16619037-1	2006	Cited (CBP/p300-interacting transactivators with glutamic acid (E)/aspartic acid (D)-rich C-terminal domain) 2, which is a CBP/p300-binding transcription co-activator without typical DNA-binding domains, has been implicated in control of cell growth and malignant transformation in Rat1 cells.	Aspartic Acid	67-80	E1A binding protein p300	Homo sapiens	11-15
16619037-1	2006	Cited (CBP/p300-interacting transactivators with glutamic acid (E)/aspartic acid (D)-rich C-terminal domain) 2, which is a CBP/p300-binding transcription co-activator without typical DNA-binding domains, has been implicated in control of cell growth and malignant transformation in Rat1 cells.	Aspartic Acid	67-80	E1A binding protein p300	Homo sapiens	127-131
16741989-8	2006	In the type I H9 and SKW6.4 cells and type II Jurkat cells, the caspase-8 inhibitor Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH2F (IETD) prevented the cell killing.	Aspartic Acid	103-106	caspase 8	Homo sapiens	64-73
16849317-5	2006	The linker region of Smad3 and the tryptophan-aspartic acid repeat 6 and 7 of RACK1 are sufficient for the association.	Aspartic Acid	46-59	SMAD family member 3	Homo sapiens	21-26
16849317-5	2006	The linker region of Smad3 and the tryptophan-aspartic acid repeat 6 and 7 of RACK1 are sufficient for the association.	Aspartic Acid	46-59	receptor for activated C kinase 1	Homo sapiens	78-83
16842743-4	2006	Our study has revealed that an intriguing Grotthuss hopping mechanism of proton transfer involving water and three conserved aspartate residues in pol beta"s active site mediates the phosphoryl transfer in the correct as well as misincorporation of nucleotides.	Aspartic Acid	125-134	DNA polymerase beta	Homo sapiens	147-155
16698014-5	2006	Subsequent sequencing of OPA1 identified a novel heterozygous missense mutation (c.1313A>G) replacing aspartic acid by glycine (p.D438G) in the GTPase domain of OPA1.	Aspartic Acid	102-115	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	25-29
16698014-5	2006	Subsequent sequencing of OPA1 identified a novel heterozygous missense mutation (c.1313A>G) replacing aspartic acid by glycine (p.D438G) in the GTPase domain of OPA1.	Aspartic Acid	102-115	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	161-165
16803893-11	2006	Mutation of an Asp residue in PimE that is conserved in and required for the activity of human PIG-M resulted in loss of PIM-biosynthetic activity, indicating that PimE is the catalytic component.	Aspartic Acid	15-18	GPI mannosyltransferase 1	Sus scrofa	95-100
16870146-1	2006	The apoptotic proteases, including caspases and granzyme B, have independent evolutionary origins, yet are both highly specific for cleavage after aspartic acid residues and cleave many of the same substrates at closely spaced sites.	Aspartic Acid	147-160	granzyme B	Homo sapiens	48-58
16951482-5	2006	A significant association between a polymorphism in the aspartic acid (D) repeat of the asporin gene (ASPN) and knee OA was found; the D14 allele of ASPN is over-represented relative to the common D13 allele, and its frequency increases with disease severity.	Aspartic Acid	56-69	asporin	Homo sapiens	102-106
17091764-3	2006	As the name implies, asparaginase catalyzes the deamination of asparagine to aspartic acid.	Aspartic Acid	77-90	asparaginase	Homo sapiens	21-33
16652375-7	2006	Ki-ras mutations, which occurred chiefly in the K(s) allele (96%), were found in 79-81% of reciprocally crossed F1 mice, 64% of C mice, and 50% of B6 mice, with the Val(12), Asp(12), and Arg(13) mutations associated with more aggressive tumors.	Aspartic Acid	174-177	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-6
16918599-10	2006	Similar to the primary tumour, the cell line showed p53 overexpression and had p53 mutation at codon 132: AAG (lys)--&gt;AAT (asp).	Aspartic Acid	126-129	tumor protein p53	Homo sapiens	79-82
16918599-10	2006	Similar to the primary tumour, the cell line showed p53 overexpression and had p53 mutation at codon 132: AAG (lys)--&gt;AAT (asp).	Aspartic Acid	126-129	serpin family A member 1	Homo sapiens	121-124
16900509-5	2006	The most frequent mutations were GGT-&gt;GAT (Gly-&gt;Asp) (37.5%), followed by GGT-&gt;GTT (Gly-&gt;Val) (31.3%), both in codon 12.	Aspartic Acid	54-57	glycine-N-acyltransferase	Homo sapiens	41-44
16807248-3	2006	This interaction is mediated by the carboxyl-terminal end of AIP, which contains three tetratricopeptide motifs, and involves the carboxyl terminus coiled coil in survivin with critical roles of Asp(142) in AIP recognition.	Aspartic Acid	195-198	aryl hydrocarbon receptor interacting protein	Homo sapiens	61-64
16938651-8	2006	The integrinalpha3beta(1) antagonists, anti-integrinbeta(1) monoclonal antibody and Gly-Arg-Gly-Asp (GRGD), decreased the expression of alpha-SMA protein and the percentage of alpha-SMA positive cells stimulated by TGF-beta(1) (both P &lt; 0.01).	Aspartic Acid	96-99	actin gamma 2, smooth muscle	Rattus norvegicus	136-145
16938651-8	2006	The integrinalpha3beta(1) antagonists, anti-integrinbeta(1) monoclonal antibody and Gly-Arg-Gly-Asp (GRGD), decreased the expression of alpha-SMA protein and the percentage of alpha-SMA positive cells stimulated by TGF-beta(1) (both P &lt; 0.01).	Aspartic Acid	96-99	actin gamma 2, smooth muscle	Rattus norvegicus	176-185
16938651-8	2006	The integrinalpha3beta(1) antagonists, anti-integrinbeta(1) monoclonal antibody and Gly-Arg-Gly-Asp (GRGD), decreased the expression of alpha-SMA protein and the percentage of alpha-SMA positive cells stimulated by TGF-beta(1) (both P &lt; 0.01).	Aspartic Acid	96-99	transforming growth factor, beta 1	Rattus norvegicus	215-226
16760361-8	2006	Based upon the three-dimensional architecture of the human beta1-AR, the distance between Lys324 and the Asp/Glu-Arg-Tyr motif in helix 3 was the shortest among the various amino acids in helix 6.	Aspartic Acid	105-108	adrenoceptor beta 1	Homo sapiens	59-67
16807248-3	2006	This interaction is mediated by the carboxyl-terminal end of AIP, which contains three tetratricopeptide motifs, and involves the carboxyl terminus coiled coil in survivin with critical roles of Asp(142) in AIP recognition.	Aspartic Acid	195-198	aryl hydrocarbon receptor interacting protein	Homo sapiens	207-210
16725213-8	2006	The Ddo(-/-) mice have D-aspartate immunoreactive cells in the cerebellum and adrenal glands that are not observed in the wild-type mice.	Aspartic Acid	25-34	D-aspartate oxidase	Mus musculus	4-7
16782707-11	2006	Mutation of amino acid Ser-536, which is located in the proteolytic susceptibility domain, to aspartic acid, inhibited calpain cleavage and reduced mutant Htt toxicity.	Aspartic Acid	94-107	huntingtin	Rattus norvegicus	155-158
16774919-6	2006	First, we showed that if one of the Mg2+ cations is removed, the Asp/Asn binding specificity is strongly reduced.	Aspartic Acid	65-68	mucin 7, secreted	Homo sapiens	36-39
16774919-11	2006	Thus, in addition to their structural and catalytic roles, the Mg2+ cations contribute to specificity in AspRS through long range electrostatic interactions with the Asp side chain in both the pre- and post-adenylation states.	Aspartic Acid	105-108	mucin 7, secreted	Homo sapiens	63-66
16893187-6	2006	We propose that a network of hydrogen bonds involving hUbc13-Asp(81) and Ub-Glu(64) positions Ub-Lys(63) proximal to the active site.	Aspartic Acid	61-64	ubiquitin conjugating enzyme E2 N	Homo sapiens	54-60
16737969-8	2006	In ZO1-PDZ1, an Asp residue makes favorable interactions with both Tyr(-1) and Lys/Arg(-3).	Aspartic Acid	16-19	tight junction protein 1	Homo sapiens	3-11
16888629-3	2006	The Nrf2 peptide contains two short antiparallel beta-strands connected by two overlapping type I beta-turns stabilized by the aspartate and threonine residues.	Aspartic Acid	127-136	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
16757479-4	2006	In GAT-1 and in most other neurotransmitter transporter family members, four of these residues are conserved, but aspartate 395 replaces the Na2 residue threonine 354.	Aspartic Acid	114-123	solute carrier family 6 member 1	Homo sapiens	3-8
16737969-9	2006	In contrast, Erbin-PDZ contains an Arg at the equivalent position, and this side chain cannot accommodate either Tyr(-1) or Lys/Arg(-3) but, instead, interacts favorably with Glu/Asp(-3).	Aspartic Acid	179-182	erbb2 interacting protein	Homo sapiens	13-22
16736097-1	2006	Citrin is a mitochondrial membrane aspartate-glutamate carrier, and citrin deficiency causes both hyperammonaemia in adults (adult-onset type II citrullinaemia, CTLN2) and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), with metabolic derangements in gluconeogenesis, aerobic glycolysis, urea synthesis, UDP-galactose epimerase activity, and possibly fatty acid synthesis and utilization.	Aspartic Acid	35-44	solute carrier family 25 member 13	Homo sapiens	0-6
16882944-11	2006	Shepherdin[79-83] made contact with unique residues in the ATP pocket of Hsp90 (Ile-96, Asp-102, and Phe-138), did not increase Hsp70 levels in AML cells, disrupted mitochondrial function within 2 minutes of treatment, and eliminated the expression of Hsp90 client proteins.	Aspartic Acid	88-91	heat shock protein 90 alpha family class A member 1	Homo sapiens	73-78
16297925-5	2006	For example the active sites of GAPDH in T. cruzi and humans differ by a substitution of ASP(210) (T. cruzi) by Leu(194) in human.	Aspartic Acid	89-92	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	32-37
16679488-0	2006	Tamoxifen and raloxifene differ in their functional interactions with aspartate 351 of estrogen receptor alpha.	Aspartic Acid	70-79	estrogen receptor 1	Homo sapiens	87-110
16816136-5	2006	Seedlings deficient in LHT1 cannot use Glu or Asp as sole nitrogen sources because of the severe inhibition of amino acid uptake from the medium, and uptake of amino acids into mesophyll protoplasts is inhibited.	Aspartic Acid	46-49	lysine histidine transporter 1	Arabidopsis thaliana	23-27
16679316-5	2006	Subsequent tandem mass spectrometric (MS/MS) analysis of the selected cross-linked peptide candidates led to the identification of two intermolecular cross-links, Lys(428)(CYP2E1)-Asp(53)(b(5)) and Lys(434)(CYP2E1)-Glu(56)(b(5)), which provides the first direct experimental evidence for the interacting orientations of a microsomal P450 and its redox partner.	Aspartic Acid	180-183	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	172-178
16679316-5	2006	Subsequent tandem mass spectrometric (MS/MS) analysis of the selected cross-linked peptide candidates led to the identification of two intermolecular cross-links, Lys(428)(CYP2E1)-Asp(53)(b(5)) and Lys(434)(CYP2E1)-Glu(56)(b(5)), which provides the first direct experimental evidence for the interacting orientations of a microsomal P450 and its redox partner.	Aspartic Acid	180-183	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	207-213
16503213-8	2006	The frequencies of the NOS3 Glu298Asp genotypes were Glu/Glu=46.2%, Glu/Asp=42.7%, and Asp/Asp=11.1%.	Aspartic Acid	34-37	nitric oxide synthase 3	Homo sapiens	23-27
16707098-1	2006	Aspartoacylase (ASPA) hydrolyzes N-acetylaspartic acid (NAA) into aspartate and acetate.	Aspartic Acid	66-75	aspartoacylase	Mus musculus	0-14
16707098-1	2006	Aspartoacylase (ASPA) hydrolyzes N-acetylaspartic acid (NAA) into aspartate and acetate.	Aspartic Acid	66-75	aspartoacylase	Mus musculus	16-20
16802828-6	2006	Saturation Transfer Difference (STD) NMR with one of these inhibitors, with linker structure (Asp-Gly-AMAB-Gly-Asp) and K(D) = 42 nM for GSTA1-1, demonstrates that the Asp-Gly linker interacts tightly with GSTA1-1, but not P1-1.	Aspartic Acid	94-97	glutathione S-transferase alpha 1	Homo sapiens	137-144
16730205-3	2006	The B. ignitus SOD1 (BiSOD1) possesses the typical metal-binding ligands of six histidines and one aspartic acid common to SOD1s.	Aspartic Acid	99-112	superoxide dismutase 1	Apis mellifera	15-19
16786512-1	2006	We describe a novel missense mutation (Aspartic acid to Asparagine, p.D419N (g.1371G&gt;A, c.1255G&gt;A) within exon 9 of SH3BP2 in a patient with cherubism, an autosomal dominant syndrome characterized by excessive osteoclastic bone resorption of the jaw.	Aspartic Acid	39-52	SH3 domain binding protein 2	Homo sapiens	122-128
16616566-4	2006	We tagged the C-terminal-anchorless TNSALP enzyme with an acidic oligopeptide (a six or eight residue stretch of L-Asp), and compared the biochemical properties of the purified tagged and untagged enzymes derived from Chinese hamster ovary cell lines.	Aspartic Acid	113-118	alkaline phosphatase, biomineralization associated	Homo sapiens	36-42
16825935-2	2006	AIM: To evaluate the performance of the aspartate to alanine aminotransferase ratio (AST/ALT ratio) and platelet count in reducing the number of liver biopsies and diagnosing the presence/absence of significant fibrosis in a large cohort of patients with CHC seen at 2 tertiary referral centers.	Aspartic Acid	40-49	solute carrier family 17 member 5	Homo sapiens	85-88
17114947-3	2006	TruA and the other (Psi synthases have a completely conserved active site aspartate, which suggests that the members of this enzyme family share a common catalytic mechanism.	Aspartic Acid	74-83	tRNA pseudouridine(38-40) synthase TruA	Thermus thermophilus HB8	0-4
16698895-2	2006	Animals and some bacteria synthesize quinolinate from tryptophan, whereas other bacteria synthesize quinolinate from aspartate (Asp) using L-Asp oxidase and quinolinate synthase.	Aspartic Acid	117-126	quinolinate synthase	Arabidopsis thaliana	157-177
16698895-2	2006	Animals and some bacteria synthesize quinolinate from tryptophan, whereas other bacteria synthesize quinolinate from aspartate (Asp) using L-Asp oxidase and quinolinate synthase.	Aspartic Acid	128-131	quinolinate synthase	Arabidopsis thaliana	157-177
16714405-7	2006	This shortfall in our basic understanding of AtPCS1 is addressed here by the results of systematic site-directed mutagenesis studies that demonstrate that not only Cys-56 but also His-162 and Asp-180 are indeed required for net PC synthesis.	Aspartic Acid	192-195	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	45-51
17114947-6	2006	Based on the TruB-tRNA complex structure, the T. thermophilus TruA structure reveals that the tRNA probably makes the melting base pairs move into the cleft, and suggests that a conformational change of the substrate tRNA is necessary to facilitate access to the active site aspartate residue, deep within the cleft.	Aspartic Acid	275-284	tRNA pseudouridine(38-40) synthase TruA	Thermus thermophilus HB8	62-66
16620747-3	2006	By this technique, activity of purified human liver cathepsin B was detected at a concentration as low as 50 ng and was blocked only in the presence of the cysteine protease inhibitor E-64 and the specific cathepsin B inhibitor CA-074 but not by aspartate, serine, or matrix metalloprotease inhibitors.	Aspartic Acid	246-255	cathepsin B	Homo sapiens	52-63
16620897-2	2006	The model incorporates the side chains of the residues tyrosine (Tyr(14)), aspartate (Asp(38)) and aspartic acid (Asp(99)) of the enzyme Delta(5)-3-ketosteroid isomerase (KSI; EC 5.3.3.1).	Aspartic Acid	75-84	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	137-169
16620897-2	2006	The model incorporates the side chains of the residues tyrosine (Tyr(14)), aspartate (Asp(38)) and aspartic acid (Asp(99)) of the enzyme Delta(5)-3-ketosteroid isomerase (KSI; EC 5.3.3.1).	Aspartic Acid	86-89	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	137-169
16620897-2	2006	The model incorporates the side chains of the residues tyrosine (Tyr(14)), aspartate (Asp(38)) and aspartic acid (Asp(99)) of the enzyme Delta(5)-3-ketosteroid isomerase (KSI; EC 5.3.3.1).	Aspartic Acid	99-112	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	137-169
16620897-2	2006	The model incorporates the side chains of the residues tyrosine (Tyr(14)), aspartate (Asp(38)) and aspartic acid (Asp(99)) of the enzyme Delta(5)-3-ketosteroid isomerase (KSI; EC 5.3.3.1).	Aspartic Acid	99-112	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	171-174
16620897-2	2006	The model incorporates the side chains of the residues tyrosine (Tyr(14)), aspartate (Asp(38)) and aspartic acid (Asp(99)) of the enzyme Delta(5)-3-ketosteroid isomerase (KSI; EC 5.3.3.1).	Aspartic Acid	114-117	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	137-169
16620897-2	2006	The model incorporates the side chains of the residues tyrosine (Tyr(14)), aspartate (Asp(38)) and aspartic acid (Asp(99)) of the enzyme Delta(5)-3-ketosteroid isomerase (KSI; EC 5.3.3.1).	Aspartic Acid	114-117	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	171-174
16768462-1	2006	IalphaI and TSG-6 interact to form a covalent bond between the C-terminal Asp alpha-carbon of an IalphaI heavy chain (HC) and an unknown component of TSG-6.	Aspartic Acid	74-77	TNF alpha induced protein 6	Homo sapiens	12-17
16768462-5	2006	The data show that although the mature covalent cross-link between the HCs and TSG-6 only involves the C-terminal Asp residue, the native fold of both IalphaI and TSG-6 was essential for the reaction to occur.	Aspartic Acid	114-117	TNF alpha induced protein 6	Homo sapiens	79-84
16608845-4	2006	The results showed that Asp-122, Lys-191, Lys-225, Lys-256, Glu-261, and Lys-312,Lys-313 residues of rat Asbt are critical for transport function and may determine substrate specificity.	Aspartic Acid	24-27	solute carrier family 10 member 2	Rattus norvegicus	105-109
16608845-7	2006	Asp-122 and Glu-261 play a critical role in the interaction of a Na(+) ion and ligand with Asbt.	Aspartic Acid	0-3	solute carrier family 10 member 2	Rattus norvegicus	91-95
16394027-4	2006	Km values of hOCT2-mediated uptake of 95 microM amiloride and 24 microM ASP were calculated.	Aspartic Acid	72-75	solute carrier family 22 member 2	Homo sapiens	13-18
16394027-8	2006	The data indicate that saturable transport by hOCT2 can be measured by the fluorescent substrates amiloride and ASP and that transport activity for both substrates is regulated similarly.	Aspartic Acid	112-115	solute carrier family 22 member 2	Homo sapiens	46-51
16627486-2	2006	Some receptors contain a TM arginine residue that interacts with Asp-11 of the FcRgamma subunit, but otherwise the molecular basis for the FcRgamma subunit interactions is largely unknown.	Aspartic Acid	65-68	Fc epsilon receptor Ig	Homo sapiens	79-87
16545906-7	2006	The cytosolic fraction was obtained from the cerebral cortical tissue following centrifugation at 100,000 x g for 1h and caspase-9 activity was assayed using Ac-Leu-Glu-His-Asp-amino-4-methyl coumarin, a specific fluorogenic substrate for caspase-9.	Aspartic Acid	173-176	caspase 9	Homo sapiens	121-130
16425277-6	2006	Sequence analysis reveals that DQB1*060101 allele encodes Leu at position 9 and Asp at position 37, unique to the susceptibility to cervical cancer, whereas the other DQB1 alleles encode Phe or Tyr and Ile or Tyr at the same two positions, respectively.	Aspartic Acid	80-83	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	31-35
16597625-4	2006	We have explored here the human mt-aspartate system in which a prokaryotic-type AspRS, highly similar to the Escherichia coli enzyme, recognizes a bizarre tRNA(Asp).	Aspartic Acid	35-44	aspartyl-tRNA synthetase 2, mitochondrial	Homo sapiens	80-85
16597625-9	2006	Replacing this glycine by an aspartate renders human mt-AspRS more discriminative to G73.	Aspartic Acid	29-38	aspartyl-tRNA synthetase 2, mitochondrial	Homo sapiens	56-61
16547592-5	2006	VPE and caspase-1 share several structural properties: the catalytic dyads and three amino acids forming the substrate pockets (Asp pocket) are conserved between VPE and caspase-1.	Aspartic Acid	128-131	caspase 1	Homo sapiens	8-17
16713178-5	2006	All anti-DFS70 Ab-positive individuals expressed at least one HLA-DQB1 allele with an aspartic acid at residue 57.	Aspartic Acid	86-99	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	62-70
16547592-5	2006	VPE and caspase-1 share several structural properties: the catalytic dyads and three amino acids forming the substrate pockets (Asp pocket) are conserved between VPE and caspase-1.	Aspartic Acid	128-131	caspase 1	Homo sapiens	170-179
16477434-3	2006	Here, we show that the analogous aspartate residue is critical for the transport function of eukaryotic family members as distant as the yeast transporter/sensor Mep2 and the human RhAG and RhCG proteins.	Aspartic Acid	33-42	ammonium permease MEP2	Saccharomyces cerevisiae S288C	162-166
16477434-3	2006	Here, we show that the analogous aspartate residue is critical for the transport function of eukaryotic family members as distant as the yeast transporter/sensor Mep2 and the human RhAG and RhCG proteins.	Aspartic Acid	33-42	Rh associated glycoprotein	Homo sapiens	181-185
16477434-7	2006	Kinetic analysis shows the Mep2(D186E) variant to be particularly affected at the level of substrate affinity, suggesting an involvement of aspartate(186) in ammonium recognition.	Aspartic Acid	140-149	ammonium permease MEP2	Saccharomyces cerevisiae S288C	27-31
16477434-9	2006	Finally, replacement of the conserved aspartate with asparagine in human RhAG and RhCG proteins resulted in the loss of bi-directional transport function.	Aspartic Acid	38-47	Rh associated glycoprotein	Homo sapiens	73-77
16723808-0	2006	Replacement of alanine with asparagic acid at position 203 in human steroidogenic acute regulatory protein impairs the ability to enhance steroidogenesis in vitro.	Aspartic Acid	28-42	steroidogenic acute regulatory protein	Homo sapiens	68-106
16713178-5	2006	All anti-DFS70 Ab-positive individuals expressed at least one HLA-DQB1 allele with an aspartic acid at residue 57.	Aspartic Acid	86-99	PC4 and SFRS1 interacting protein 1	Homo sapiens	9-14
16935250-3	2006	On the peptide array, the relative cell-adhesion ratio of NIH/3T3 cells was 2.5-fold higher on the RGDS (Arg-Gly-Asp-Ser) peptide spot as compared to the spot with no peptide, thus indicating integrin-mediated peptide-cell interaction.	Aspartic Acid	113-116	ral guanine nucleotide dissociation stimulator	Mus musculus	99-103
16731937-4	2006	The species specificity of the interaction is controlled by amino acid 128, which is aspartate in hA3G and lysine in rhA3G.	Aspartic Acid	85-94	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	98-102
16816908-4	2006	This newly described mutation predicts the substitution of an aspartate by asparagine (D770N) in the second fibronectin (Fn2) domain of the extracellular portion of the mature L1 protein.	Aspartic Acid	62-71	fibronectin 1	Homo sapiens	108-119
16681386-7	2006	Using in silico molecular modeling procedures, we have now identified a second putative amino acid involved in acyl-CoA specificity (Asp(356) in rat CrAT).	Aspartic Acid	133-136	carnitine O-acetyltransferase	Rattus norvegicus	149-153
16377215-2	2006	The Asporin (ASPN) gene which encodes a protein of the extracellular cartilage matrix contains a triplet repeat encoding for aspartic acid (D) within exon 2 The D14 allele was found associated with knee and hip osteoarthritis in case-control study in the Japanese population.	Aspartic Acid	125-138	asporin	Homo sapiens	4-11
16377215-2	2006	The Asporin (ASPN) gene which encodes a protein of the extracellular cartilage matrix contains a triplet repeat encoding for aspartic acid (D) within exon 2 The D14 allele was found associated with knee and hip osteoarthritis in case-control study in the Japanese population.	Aspartic Acid	125-138	asporin	Homo sapiens	13-17
16488889-5	2006	Among these three residues, phosphorylation of serine 282 seemed to be the most important for NDR2 activation (the same as for the mouse homologue) because its aspartic acid-converted mutant (NDR2/S282D) induced ARK5-mediated cell survival and invasion activities even in the absence of IGF-1.	Aspartic Acid	160-173	serine/threonine kinase 38 like	Mus musculus	94-98
16488889-5	2006	Among these three residues, phosphorylation of serine 282 seemed to be the most important for NDR2 activation (the same as for the mouse homologue) because its aspartic acid-converted mutant (NDR2/S282D) induced ARK5-mediated cell survival and invasion activities even in the absence of IGF-1.	Aspartic Acid	160-173	serine/threonine kinase 38 like	Mus musculus	192-196
16488889-5	2006	Among these three residues, phosphorylation of serine 282 seemed to be the most important for NDR2 activation (the same as for the mouse homologue) because its aspartic acid-converted mutant (NDR2/S282D) induced ARK5-mediated cell survival and invasion activities even in the absence of IGF-1.	Aspartic Acid	160-173	insulin-like growth factor 1	Mus musculus	287-292
16794859-5	2006	D: -aspartate partially reverted the glutamate effect on S100B release and two other inhibitors, PDC and DIDS, reverted it completely.	Aspartic Acid	4-13	S100 calcium binding protein B	Homo sapiens	57-62
16672239-4	2006	Serine protease templates built from evolutionarily important residues distinguish between proteases and other proteins nearly as well as the classic Ser-His-Asp catalytic triad.	Aspartic Acid	158-161	coagulation factor II, thrombin	Homo sapiens	0-15
16569642-3	2006	In addition, IGFBP2 has an Arg-Gly-Asp (RGD) domain, which is a known integrin binding motif.	Aspartic Acid	35-38	insulin like growth factor binding protein 2	Homo sapiens	13-19
16574906-8	2006	This occurred via an Arg-Gly-Asp (RGD) peptide-independent pathway through activation of G(i/o) proteins, phosphatidylinositol 3-kinase, Akt, and eNOS.	Aspartic Acid	29-32	nitric oxide synthase 3, endothelial cell	Mus musculus	146-150
16517082-5	2006	Indeed, we show that the O-GlcNAcase also possesses the catalytic doublet motif shared among these enzymes and that these two essential residues are aspartic acids at positions 175 and 177, respectively, in mouse NCOAT.	Aspartic Acid	149-163	O-GlcNAcase	Mus musculus	213-218
16601678-3	2006	Early induced p53 allows caspase-mediated cleavage of HIPK2 following aspartic acids 916 and 977.	Aspartic Acid	70-84	tumor protein p53	Homo sapiens	14-17
16601678-3	2006	Early induced p53 allows caspase-mediated cleavage of HIPK2 following aspartic acids 916 and 977.	Aspartic Acid	70-84	homeodomain interacting protein kinase 2	Homo sapiens	54-59
16821621-0	2006	Variations of soluble fas and cytokeratin 18-Asp 396 neo-epitope in different cancers during chemotherapy.	Aspartic Acid	45-48	keratin 18	Homo sapiens	30-44
16601148-2	2006	EAAT4, a neuronally expressed EAAT in cerebellum, has a large portion (approximately 95% of the total L-aspartate-induced currents in human EAAT4) of substrate-gated Cl(-) currents, a distinct feature of this EAAT.	Aspartic Acid	102-113	solute carrier family 1 member 6	Homo sapiens	0-5
16601148-2	2006	EAAT4, a neuronally expressed EAAT in cerebellum, has a large portion (approximately 95% of the total L-aspartate-induced currents in human EAAT4) of substrate-gated Cl(-) currents, a distinct feature of this EAAT.	Aspartic Acid	102-113	solute carrier family 1 member 6	Homo sapiens	140-145
16441242-6	2006	The WPD loop of PTPRR was open; however, in contrast with the structure of its mouse homologue, PTPSL, a salt bridge between the conserved lysine and aspartate residues, which has been postulated to confer a more rigid loop structure, thereby modulating activity in PTPSL, does not form in PTPRR.	Aspartic Acid	150-159	protein tyrosine phosphatase, receptor type, R	Mus musculus	16-21
16441242-6	2006	The WPD loop of PTPRR was open; however, in contrast with the structure of its mouse homologue, PTPSL, a salt bridge between the conserved lysine and aspartate residues, which has been postulated to confer a more rigid loop structure, thereby modulating activity in PTPSL, does not form in PTPRR.	Aspartic Acid	150-159	protein tyrosine phosphatase, receptor type, R	Mus musculus	96-101
16675334-11	2006	Relationships with serum-specific IgE levels, which could only be assessed in 41% at age 4 years, were less pronounced and statistically significant only for EPS-Pen/Asp.	Aspartic Acid	166-169	immunoglobulin heavy constant epsilon	Homo sapiens	34-37
16441242-6	2006	The WPD loop of PTPRR was open; however, in contrast with the structure of its mouse homologue, PTPSL, a salt bridge between the conserved lysine and aspartate residues, which has been postulated to confer a more rigid loop structure, thereby modulating activity in PTPSL, does not form in PTPRR.	Aspartic Acid	150-159	protein tyrosine phosphatase, receptor type, R	Mus musculus	266-271
16441242-6	2006	The WPD loop of PTPRR was open; however, in contrast with the structure of its mouse homologue, PTPSL, a salt bridge between the conserved lysine and aspartate residues, which has been postulated to confer a more rigid loop structure, thereby modulating activity in PTPSL, does not form in PTPRR.	Aspartic Acid	150-159	protein tyrosine phosphatase, receptor type, R	Mus musculus	290-295
16458993-1	2006	BACKGROUND/AIMS: Mutations in SLC25A13, encoding the mitochondrial aspartate-glutamate carrier citrin, cause adult-onset type II citrullinemia (CTLN2) in humans.	Aspartic Acid	67-76	solute carrier family 25 member 13	Homo sapiens	30-38
16458993-1	2006	BACKGROUND/AIMS: Mutations in SLC25A13, encoding the mitochondrial aspartate-glutamate carrier citrin, cause adult-onset type II citrullinemia (CTLN2) in humans.	Aspartic Acid	67-76	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	95-101
16458993-1	2006	BACKGROUND/AIMS: Mutations in SLC25A13, encoding the mitochondrial aspartate-glutamate carrier citrin, cause adult-onset type II citrullinemia (CTLN2) in humans.	Aspartic Acid	67-76	solute carrier family 25 member 13	Homo sapiens	144-149
16606369-1	2006	The tangles of Alzheimer"s disease (AD) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (S422) and truncation at aspartic acid 421 (D421).	Aspartic Acid	171-184	microtubule associated protein tau	Homo sapiens	61-64
16493674-5	2006	Mutation of S204 to aspartate, which introduces a permanent negative charge, also impairs MPZ movement to the plasma membrane.	Aspartic Acid	20-29	myelin protein zero	Homo sapiens	90-93
16604067-2	2006	The abnormal behavior of unc-17(e245) mutants, which have a glycine-to-arginine substitution in a transmembrane domain, is markedly improved by a mutant synaptobrevin with an isoleucine-to-aspartate substitution in its transmembrane domain.	Aspartic Acid	189-198	Vesicular acetylcholine transporter unc-17	Caenorhabditis elegans	25-31
16515538-8	2006	Consistently, neutralization of aspartates D218 and D220 in DOC2B changed its calcium affinity.	Aspartic Acid	32-42	double C2 domain beta	Homo sapiens	60-65
16427346-8	2006	A 1876G&gt;A substitution changing an aspartic acid to asparagine (D626N) was identified in LDB3 in four members of two families with LVNC.	Aspartic Acid	38-51	LIM domain binding 3	Homo sapiens	92-96
16640460-5	2006	An interesting aspect of the Src-like inactive structure, suggested by molecular dynamics simulations and additional crystal structures, is the presence of features that might facilitate the flip of the DFG motif by providing room for the phenylalanine to move and by coordinating the aspartate side chain as it leaves the active site.	Aspartic Acid	285-294	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	29-32
16459334-6	2006	Furthermore, co-mutation of the Lys(212)-Lys(216) residues with the -3/-7 dilysine signal produced a dramatic increase in alpha-chain surface expression that was further increased by co-mutation of the lone charged residue (Asp(192)) in the TMD thereby defining three regions that function to regulate alpha-chain transport and in a highly synergistic manner.	Aspartic Acid	224-227	Fc gamma receptor and transporter	Homo sapiens	122-133
16786295-9	2006	The recombinant LaNIT4 enzymes, like Arabidopsis NIT4, hydrolyze cyanoalanine to asparagine and aspartic acid but show a much higher cyanoalanine-hydratase activity.	Aspartic Acid	96-109	nitrilase 4	Arabidopsis thaliana	18-22
16671952-2	2006	HLA typing was performed by different molecular biology techniques, and the results showed that the HLA-DRB5*0113 allele differs from HLA-DRB5*010101 allele for three nucleotide substitutions at codons 57 (GAC--&gt;GAT; Asp) and 58 (GCT--&gt;GAG; Ala--&gt;Glu) of exon 2.	Aspartic Acid	220-223	major histocompatibility complex, class II, DR beta 5	Homo sapiens	100-108
16671952-2	2006	HLA typing was performed by different molecular biology techniques, and the results showed that the HLA-DRB5*0113 allele differs from HLA-DRB5*010101 allele for three nucleotide substitutions at codons 57 (GAC--&gt;GAT; Asp) and 58 (GCT--&gt;GAG; Ala--&gt;Glu) of exon 2.	Aspartic Acid	220-223	major histocompatibility complex, class II, DR beta 5	Homo sapiens	134-142
16618936-8	2006	Notably the residues essential for GGT activity (Arg-114, Asp-433, Ser-462, and Ser-463 in E. coli GGT) shown by site-directed mutagenesis of human GGT are all involved in the binding of the gamma-glutamyl moiety.	Aspartic Acid	58-61	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	35-38
16618936-8	2006	Notably the residues essential for GGT activity (Arg-114, Asp-433, Ser-462, and Ser-463 in E. coli GGT) shown by site-directed mutagenesis of human GGT are all involved in the binding of the gamma-glutamyl moiety.	Aspartic Acid	58-61	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	99-102
16618936-8	2006	Notably the residues essential for GGT activity (Arg-114, Asp-433, Ser-462, and Ser-463 in E. coli GGT) shown by site-directed mutagenesis of human GGT are all involved in the binding of the gamma-glutamyl moiety.	Aspartic Acid	58-61	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	99-102
16603626-8	2006	On the other hand, that of loop 2 (dependent on drawing close two myosin lysines and two actin aspartates) is probably responsible for opening switch I and uncovering the gamma-phosphate moiety of bound ATP.	Aspartic Acid	95-105	myosin heavy chain 14	Homo sapiens	66-72
16289913-5	2006	The expression of all subunits increased with increase in infection time up to 72 h. We have also over expressed three mutant forms of eIF2alpha viz, S51A, S51D, and S48A in which the serine at 51 or 48 position is replaced by an alanine or aspartic acid with 6x histidine tag at the N-terminus.	Aspartic Acid	241-254	eukaryotic translation initiation factor 2A	Homo sapiens	135-144
16640778-10	2006	Mutating residues Thr13 or Phe82 located in cluster 3 to aspartate results in super-agonistic IL-4 variants.	Aspartic Acid	57-66	interleukin 4	Homo sapiens	94-98
16606821-0	2006	Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.	Aspartic Acid	16-29	insulin induced gene 1	Homo sapiens	33-40
16606821-0	2006	Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.	Aspartic Acid	16-29	insulin induced gene 2	Homo sapiens	45-52
16606821-2	2006	Here, we report that the conserved Asp-205 in Insig-1, which abuts the fourth transmembrane helix at the cytosolic side of the ER membrane, is essential for its dual function.	Aspartic Acid	35-38	insulin induced gene 1	Homo sapiens	46-53
16606821-5	2006	Alanine substitution of the corresponding aspartic acid in Insig-2 produced the same dual defects.	Aspartic Acid	42-55	insulin induced gene 2	Homo sapiens	59-66
16478724-0	2006	Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.	Aspartic Acid	22-35	solute carrier family 1 member 1	Homo sapiens	162-167
16478724-0	2006	Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.	Aspartic Acid	44-47	solute carrier family 1 member 1	Homo sapiens	162-167
16478724-3	2006	Here, we have investigated the possible involvement of two conserved aspartic acid residues in transmembrane segments 7 and 8 of EAAC1, Asp-367 and Asp-454, in Na(+) cotransport.	Aspartic Acid	69-82	solute carrier family 1 member 1	Homo sapiens	129-134
16478724-3	2006	Here, we have investigated the possible involvement of two conserved aspartic acid residues in transmembrane segments 7 and 8 of EAAC1, Asp-367 and Asp-454, in Na(+) cotransport.	Aspartic Acid	136-139	solute carrier family 1 member 1	Homo sapiens	129-134
16459334-6	2006	Furthermore, co-mutation of the Lys(212)-Lys(216) residues with the -3/-7 dilysine signal produced a dramatic increase in alpha-chain surface expression that was further increased by co-mutation of the lone charged residue (Asp(192)) in the TMD thereby defining three regions that function to regulate alpha-chain transport and in a highly synergistic manner.	Aspartic Acid	224-227	Fc gamma receptor and transporter	Homo sapiens	302-313
16463158-2	2006	This study investigated the relationship of the eNOS Glu298 --&gt; Asp polymorphism with the presence and severity of BD in the Turkish population.	Aspartic Acid	67-70	nitric oxide synthase 3	Homo sapiens	48-52
16464860-10	2006	The His-to-Asp phosphorelay system consisting of three histidine kinases (Phk1, Phk2, and Phk3), a phosphorelay protein (Spy1), and a response regulator (Mcs4) exists upstream of the Spc1-SAPK pathway.	Aspartic Acid	11-14	signal peptidase complex subunit 1	Homo sapiens	183-187
16516870-4	2006	A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related peptide (CGRP) and parvalbumin; 22% and 14% of aspartate-immunoreactive (ir) neurons were also immunoreactive for CGRP and parvalbumin, respectively.	Aspartic Acid	65-74	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	80-111
16516870-4	2006	A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related peptide (CGRP) and parvalbumin; 22% and 14% of aspartate-immunoreactive (ir) neurons were also immunoreactive for CGRP and parvalbumin, respectively.	Aspartic Acid	65-74	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	113-117
16516870-4	2006	A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related peptide (CGRP) and parvalbumin; 22% and 14% of aspartate-immunoreactive (ir) neurons were also immunoreactive for CGRP and parvalbumin, respectively.	Aspartic Acid	65-74	parvalbumin	Mus musculus	123-134
16516870-5	2006	The co-expression of aspartate with both CGRP and parvalbumin was very rare in the TG.	Aspartic Acid	21-30	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	41-45
16516870-5	2006	The co-expression of aspartate with both CGRP and parvalbumin was very rare in the TG.	Aspartic Acid	21-30	parvalbumin	Mus musculus	50-61
16516870-7	2006	The co-expression of aspartate with CGRP was more common among palatal neurons (36%) compared to vibrissal neurons (22%).	Aspartic Acid	21-30	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	36-40
16516870-8	2006	Aspartate-ir neurons which co-expressed parvalbumin-ir were numerous in the vibrissa (17%) but not in the palate (4%).	Aspartic Acid	0-9	parvalbumin	Mus musculus	40-51
16487484-1	2006	A key step decisively affecting the catalytic efficiency of copper amine oxidase is stereospecific abstraction of substrate alpha-proton by a conserved Asp residue.	Aspartic Acid	152-155	amine oxidase copper containing 3	Homo sapiens	60-80
16463158-7	2006	Glu298 --&gt; Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population.	Aspartic Acid	14-17	nitric oxide synthase 3	Homo sapiens	38-42
16623712-5	2006	In particular, the fluorogenic substrate Mca-Ala-Ser-Asp-Lys-DpaOH was shown to be a strict N-domain-selective substrate of mouse ACE, whereas with rat ACE it displayed marked C-domain selectivity.	Aspartic Acid	53-57	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	130-133
16623712-5	2006	In particular, the fluorogenic substrate Mca-Ala-Ser-Asp-Lys-DpaOH was shown to be a strict N-domain-selective substrate of mouse ACE, whereas with rat ACE it displayed marked C-domain selectivity.	Aspartic Acid	53-57	angiotensin I converting enzyme	Rattus norvegicus	152-155
16581346-3	2006	As disruption of mitochondrial transmembrane potential (DeltaPsim), Leu-Glu-His-Asp ase (IETD ase) activity, and the appearance of hypodiploid DNA + cells were markedly suppressed in IFN-gamma-treated FLS in response to TRAIL, IFN-gamma-induced suppression was supposed to achieve at upstream of caspase-8.	Aspartic Acid	80-83	interferon gamma	Homo sapiens	183-192
16789430-3	2006	Berberine was found to readily fit within the binding pocket of h-PTP 1B in a low energy orientation characterized with optimal electrostatic attractive interactions bridging the isoquinolinium positively charged nitrogen atom of berberine and the negatively charged acidic residue of ASP 48 of h-PTP 1B.	Aspartic Acid	285-288	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	66-72
16741238-5	2006	Examination of the IRAK-4 DD crystal structure reveals a single manganese ion coordinated to surface residues lysine-21 and aspartate-24.	Aspartic Acid	124-133	interleukin 1 receptor associated kinase 4	Homo sapiens	19-25
16537470-5	2006	The overall binding mode of GalA-GSL to mCD1d is similar to that of the short-chain alpha-GalCer ligand PBS-25, but its sphinganine chain is more deeply inserted into the F" pocket due to alternate hydrogen-bonding interactions between the sphinganine 3-OH with Asp-80.	Aspartic Acid	262-265	CD1 antigen complex	Mus musculus	40-44
16628247-6	2006	Through a detailed case study of cyclin-dependent kinase 2, we also illustrate how the computational methods can be used to provide new understanding of how phosphorylation drives conformational change, why substituting Glu or Asp for a phosphorylated amino acid does not always mimic the effects of phosphorylation, and how a phosphatase can "capture" a phosphorylated amino acid.	Aspartic Acid	227-230	cyclin dependent kinase 2	Homo sapiens	33-58
16428384-2	2006	Murine thrombin has Asp-222 in the Na+ binding site of the human enzyme replaced by Lys.	Aspartic Acid	20-23	coagulation factor II	Mus musculus	7-15
16413576-1	2006	The antigen-binding fragment Fab-YADS2 recognizes vascular endothelial growth factor (VEGF) and was derived from a library with chemical diversity restricted to only four amino acids (Tyr, Ser, Ala and Asp).	Aspartic Acid	202-205	FA complementation group B	Homo sapiens	29-32
16566829-9	2006	EAAC1 expression and high-affinity L-aspartate transport are correspondingly down-regulated by EAAC1 siRNA knock down.	Aspartic Acid	35-46	solute carrier family 1 member 1	Homo sapiens	95-100
16566829-10	2006	Exposure of prostate cells to physiological levels of prolactin or testosterone results in an up-regulation of EAAC1 expression and a corresponding increase in the high-affinity transport of L-aspartate into the cells.	Aspartic Acid	191-202	solute carrier family 1 member 1	Homo sapiens	111-116
16566829-11	2006	CONCLUSION: This study shows that EAAC1 functions as the high-affinity L-aspartate transporter that is responsible for the uptake and accumulation of aspartate in prostate cells.	Aspartic Acid	73-82	solute carrier family 1 member 1	Homo sapiens	34-39
16476987-6	2006	Expression and characterization of a range of bacterially expressed forms of this enzyme suggest that the active X domain comprises pp1a/pp1ab residues Asp(1320)-Ser(1486).	Aspartic Acid	152-155	protein phosphatase 1 catalytic subunit alpha	Homo sapiens	132-136
16491292-0	2006	Deletion of aspartate 182 in OPG causes juvenile Paget"s disease by impairing both protein secretion and binding to RANKL.	Aspartic Acid	12-21	TNF receptor superfamily member 11b	Homo sapiens	29-32
16491292-0	2006	Deletion of aspartate 182 in OPG causes juvenile Paget"s disease by impairing both protein secretion and binding to RANKL.	Aspartic Acid	12-21	TNF superfamily member 11	Homo sapiens	116-121
16491292-5	2006	We recently reported a family with JPD in which affected members were homozygous for an in-frame mutation resulting in the deletion of aspartate 182 in OPG.	Aspartic Acid	135-144	TNF receptor superfamily member 11b	Homo sapiens	152-155
16491292-15	2006	CONCLUSIONS: Taken together, these data suggest that the deletion of aspartate 182 impairs both the secretion and activity of OPG, which in turn provides an explanation for the increased osteoclastogenesis and high bone turnover observed in JPD patients with this mutation.	Aspartic Acid	69-78	TNF receptor superfamily member 11b	Homo sapiens	126-129
16534870-8	2006	The second mutation was found in exon 3 codon 127 of the hMSH2 gene, resulting in Asp-->Ser substitution.	Aspartic Acid	82-85	mutS homolog 2	Homo sapiens	57-62
16283201-0	2006	Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel.	Aspartic Acid	55-64	potassium voltage-gated channel subfamily B member 1	Homo sapiens	103-108
16283201-4	2006	Point mutations identified the highly conserved aspartate residue immediately following the selectivity filter as a critical determinant of the antagonism between external K+ and Cd2+ ions.	Aspartic Acid	48-57	CD2 molecule	Homo sapiens	179-182
16481613-5	2006	In the present study we identified key aspartic acid residues on calstabin2 that are involved in binding to RyR2 and likely play a role in PKA phosphorylation-induced dissociation of calstabin2 from RyR2.	Aspartic Acid	39-52	FK506 binding protein 1b	Mus musculus	65-75
16481613-5	2006	In the present study we identified key aspartic acid residues on calstabin2 that are involved in binding to RyR2 and likely play a role in PKA phosphorylation-induced dissociation of calstabin2 from RyR2.	Aspartic Acid	39-52	ryanodine receptor 2, cardiac	Mus musculus	108-112
16481613-5	2006	In the present study we identified key aspartic acid residues on calstabin2 that are involved in binding to RyR2 and likely play a role in PKA phosphorylation-induced dissociation of calstabin2 from RyR2.	Aspartic Acid	39-52	FK506 binding protein 1b	Mus musculus	183-193
16481613-5	2006	In the present study we identified key aspartic acid residues on calstabin2 that are involved in binding to RyR2 and likely play a role in PKA phosphorylation-induced dissociation of calstabin2 from RyR2.	Aspartic Acid	39-52	ryanodine receptor 2, cardiac	Mus musculus	199-203
16481613-6	2006	We show that a mutant calstabin2 in which a key negatively charged residue (Asp-37) has been neutralized binds to a mutant RyR2 channel that mimics constitutively PKA-phosphorylated RyR2 (RyR2-S2808D).	Aspartic Acid	76-79	FK506 binding protein 1b	Mus musculus	22-32
16481613-6	2006	We show that a mutant calstabin2 in which a key negatively charged residue (Asp-37) has been neutralized binds to a mutant RyR2 channel that mimics constitutively PKA-phosphorylated RyR2 (RyR2-S2808D).	Aspartic Acid	76-79	ryanodine receptor 2, cardiac	Mus musculus	123-127
16481613-6	2006	We show that a mutant calstabin2 in which a key negatively charged residue (Asp-37) has been neutralized binds to a mutant RyR2 channel that mimics constitutively PKA-phosphorylated RyR2 (RyR2-S2808D).	Aspartic Acid	76-79	ryanodine receptor 2, cardiac	Mus musculus	182-186
16481613-6	2006	We show that a mutant calstabin2 in which a key negatively charged residue (Asp-37) has been neutralized binds to a mutant RyR2 channel that mimics constitutively PKA-phosphorylated RyR2 (RyR2-S2808D).	Aspartic Acid	76-79	ryanodine receptor 2, cardiac	Mus musculus	182-186
16405520-7	2006	RESULTS: In vitro adhesion assays revealed that VWF is able to promote a dose-dependent adhesion of B16-BL6 cells via its Arg-Gly-Asp (RGD) sequence.	Aspartic Acid	130-133	Von Willebrand factor	Mus musculus	48-51
16394101-8	2006	Aspartate substitution of these sites reduces NMHC-IIB localization into cytoskeleton.	Aspartic Acid	0-9	myosin heavy chain 10	Homo sapiens	46-54
16492767-4	2006	In eukaryotes, ATE1-encoded arginyl-transferases (R(D,E,C*)-transferases) conjugate Arg (R), an Nd(p) residue, to Nd(s) residues Asp (D), Glu (E), or oxidized Cys residue (C*).	Aspartic Acid	129-132	arginyltransferase 1	Homo sapiens	15-19
16386699-1	2006	A probe consisting of Discosoma red fluorescent protein (DsRed) and enhanced yellow fluorescent protein (EYFP) linked by a 19-amino-acid chain containing the caspase-3 cleavage site Asp-Glu-Val-Asp was developed to monitor caspase-3 activation in living cells.	Aspartic Acid	182-185	caspase 3	Mus musculus	158-167
16475804-9	2006	These results demonstrate that both the charge and the large size of an Asp residue in this position contribute to the severe effects seen in a patient with the G473D mutation, by causing partial misfolding and monomerization of sulfite oxidase and attenuating both substrate binding and catalytic efficiency during the reaction cycle.	Aspartic Acid	72-75	sulfite oxidase	Homo sapiens	229-244
16286477-3	2006	In vitro studies identify caspase-3 as the preferred enzyme that cleaves desmoglein 1 within its unique repeating unit domain at aspartic acid 888, part of a consensus sequence not conserved among the other desmosomal cadherins.	Aspartic Acid	129-142	caspase 3	Homo sapiens	26-35
16286477-3	2006	In vitro studies identify caspase-3 as the preferred enzyme that cleaves desmoglein 1 within its unique repeating unit domain at aspartic acid 888, part of a consensus sequence not conserved among the other desmosomal cadherins.	Aspartic Acid	129-142	desmoglein 1	Homo sapiens	73-85
16451048-4	2006	A three-dimensional crystal structure of 7 in complex with BACE-1 revealed that the amino group of the inhibitor core engages the catalytic aspartates in a manner analogous to hydroxyl groups in HE inhibitors.	Aspartic Acid	140-150	beta-secretase 1	Homo sapiens	59-65
16324807-5	2006	A stable formulation of CPT-loaded micelles was obtained using PEG-P(Asp) with PEG of 5,000 (MW), 27 Asp units, and 57-75% benzyl esterification of Asp residue.	Aspartic Acid	69-72	choline phosphotransferase 1	Homo sapiens	24-27
16324807-5	2006	A stable formulation of CPT-loaded micelles was obtained using PEG-P(Asp) with PEG of 5,000 (MW), 27 Asp units, and 57-75% benzyl esterification of Asp residue.	Aspartic Acid	101-104	choline phosphotransferase 1	Homo sapiens	24-27
16324807-5	2006	A stable formulation of CPT-loaded micelles was obtained using PEG-P(Asp) with PEG of 5,000 (MW), 27 Asp units, and 57-75% benzyl esterification of Asp residue.	Aspartic Acid	101-104	choline phosphotransferase 1	Homo sapiens	24-27
16441297-1	2006	A missense G-A SNP in the porcine melanocortin-4 receptor (MC4R) gene that causes an Asp-Asn substitution at position 298 of the corresponding MC4R protein is considered to be economically important, although published results on its effect are inconsistent.	Aspartic Acid	85-88	melanocortin 4 receptor	Sus scrofa	34-57
16441297-1	2006	A missense G-A SNP in the porcine melanocortin-4 receptor (MC4R) gene that causes an Asp-Asn substitution at position 298 of the corresponding MC4R protein is considered to be economically important, although published results on its effect are inconsistent.	Aspartic Acid	85-88	melanocortin 4 receptor	Sus scrofa	59-63
16441297-1	2006	A missense G-A SNP in the porcine melanocortin-4 receptor (MC4R) gene that causes an Asp-Asn substitution at position 298 of the corresponding MC4R protein is considered to be economically important, although published results on its effect are inconsistent.	Aspartic Acid	85-88	melanocortin 4 receptor	Sus scrofa	143-147
16078310-6	2006	The calibration curve was linear in the range 10-280 microg mL-1 for L-aspartic acid and 20-280 microg mL-1 for L-ornithine (for both amino acids, r=0.999).	Aspartic Acid	69-84	L1 cell adhesion molecule	Mus musculus	60-64
16489927-4	2006	Key intermediates of nitrogen metabolism (glutamate, glutamine, and aspartate) are involved in the regulation of NADP-IDH and AsAT.	Aspartic Acid	68-77	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	126-130
16282358-6	2006	Concomitant with its effects on local VP release, PACAP also reduces basal glutamate and aspartate release in the euhydrated rat SON.	Aspartic Acid	89-98	adenylate cyclase activating polypeptide 1	Rattus norvegicus	50-55
16408313-2	2006	For aspartyl-tRNA synthetase (AspRS), electrostatic interactions are expected to play an important role, since its three substrates (aspartate, ATP, tRNA) are all electrically charged.	Aspartic Acid	133-142	aspartyl-tRNA synthetase 1	Homo sapiens	4-28
16408313-2	2006	For aspartyl-tRNA synthetase (AspRS), electrostatic interactions are expected to play an important role, since its three substrates (aspartate, ATP, tRNA) are all electrically charged.	Aspartic Acid	133-142	aspartyl-tRNA synthetase 1	Homo sapiens	30-35
16408313-3	2006	We used molecular-dynamics free-energy simulations and experiments to compare the binding of the substrate Asp and its electrically neutral analogue Asn to AspRS.	Aspartic Acid	107-110	aspartyl-tRNA synthetase 1	Homo sapiens	156-161
16408313-8	2006	Thus, AspRS specificity is assisted by a labile proton and a cosubstrate, and ATP acts as a mobile discriminator for specific Asp binding to AspRS.	Aspartic Acid	6-9	aspartyl-tRNA synthetase 1	Homo sapiens	141-146
16479084-3	2006	Direct sequencing of WT1 PCR products from genomic DNA identified WT1 mutations in exons 8 (366 Arg&gt;His) and 9 (396 Asp&gt;Tyr).	Aspartic Acid	119-122	WT1 transcription factor	Homo sapiens	21-24
16418218-8	2006	Immunoprecipitation analysis showed that JAM-A interacts with integrin alpha(v)beta(3), and this association was increased by engagement of the ligand-binding site of the integrin by Arg-Gly-Asp-Ser (RGDS) peptide.	Aspartic Acid	191-194	F11 receptor	Homo sapiens	41-46
16418218-8	2006	Immunoprecipitation analysis showed that JAM-A interacts with integrin alpha(v)beta(3), and this association was increased by engagement of the ligand-binding site of the integrin by Arg-Gly-Asp-Ser (RGDS) peptide.	Aspartic Acid	191-194	integrin subunit alpha V	Homo sapiens	62-85
16479084-3	2006	Direct sequencing of WT1 PCR products from genomic DNA identified WT1 mutations in exons 8 (366 Arg&gt;His) and 9 (396 Asp&gt;Tyr).	Aspartic Acid	119-122	WT1 transcription factor	Homo sapiens	66-69
16439531-4	2006	Using site-directed mutagenesis, we show that a single mutation of Asn463 in FLVCR2 ECL6 to an acidic Asp residue (a residue present in the corresponding position 487 in FLVCR1 ECL6) is sufficient to render FLVCR2 functional as an FeLV-C receptor.	Aspartic Acid	102-105	FLVCR heme transporter 2	Homo sapiens	77-83
16371010-5	2006	In cells from wild-type animals, (S)-3,5-dihydroxyphenylglycine (DHPG) caused an immediate protein kinase C (PKC)-dependent up-regulation of aspartate uptake that reflected the activation of GLT-1.	Aspartic Acid	141-150	solute carrier family 1 member 2	Rattus norvegicus	191-196
16439531-4	2006	Using site-directed mutagenesis, we show that a single mutation of Asn463 in FLVCR2 ECL6 to an acidic Asp residue (a residue present in the corresponding position 487 in FLVCR1 ECL6) is sufficient to render FLVCR2 functional as an FeLV-C receptor.	Aspartic Acid	102-105	FLVCR heme transporter 1	Homo sapiens	170-176
16439531-4	2006	Using site-directed mutagenesis, we show that a single mutation of Asn463 in FLVCR2 ECL6 to an acidic Asp residue (a residue present in the corresponding position 487 in FLVCR1 ECL6) is sufficient to render FLVCR2 functional as an FeLV-C receptor.	Aspartic Acid	102-105	FLVCR heme transporter 2	Homo sapiens	207-213
16179380-8	2006	Mutations of aspartate 351 and leucine 372 can inhibit ERalpha transcriptional activity gained at high concentrations and discriminate concentration-inducible ERalpha function from that induced by estrogen.	Aspartic Acid	13-22	estrogen receptor 1	Homo sapiens	55-62
16465590-5	2006	In this article we report that pcd5J results from the insertion of a single GAC triplet encoding an aspartic acid residue at position 775 of Nna1.	Aspartic Acid	100-113	ATP/GTP binding protein 1	Mus musculus	141-145
16179380-8	2006	Mutations of aspartate 351 and leucine 372 can inhibit ERalpha transcriptional activity gained at high concentrations and discriminate concentration-inducible ERalpha function from that induced by estrogen.	Aspartic Acid	13-22	estrogen receptor 1	Homo sapiens	159-166
16205735-9	2006	A base pair change (rs1556314) in exon 11 of TRPM2, which caused a change from an aspartic acid to a glutamic acid at peptide position 543 was found.	Aspartic Acid	82-95	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	45-50
16337487-6	2006	Binding studies of Y1-scFv to cells and to synthetic peptides in vitro indicated that of the seven residues comprising the epitope only sulfo-Tyr-276 and adjacent Asp-277 are critical for the interaction.	Aspartic Acid	163-166	immunglobulin heavy chain variable region	Homo sapiens	22-26
16310227-4	2006	We show that, in addition to glutamate (Glu), cysteine, aspartate and asparagine also lead to the activation of mGlu3, 4 and 5.	Aspartic Acid	56-65	glutamate receptor, metabotropic 3	Mus musculus	112-117
16278211-8	2006	Critical vicinal acidic amino acids in ARH3, identified by mutagenesis (Asp(77) and Asp(78)), are located in a region similar to that required for activity in ARH1 but different from the location of the critical vicinal glutamates in the PARG catalytic site.	Aspartic Acid	72-75	ADP-ribosylserine hydrolase	Homo sapiens	39-43
16415881-3	2006	Collectively, our data reveal that SET7/9 recognizes a conserved K/R-S/T/A motif preceding the lysine substrate and has a propensity to bind aspartates and asparagines on the C-terminal side of the lysine target.	Aspartic Acid	141-151	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	35-41
16291754-3	2006	We have focused on two cysteine residues (Cys(88) and Cys(120)), which form a disulfide bridge in the N-terminal domain of calreticulin, on a tryptophan residue located in the carbohydrate binding site (Trp(302)), and on certain residues located at the tip of the "hairpin-like" P-domain of the protein (Glu(238), Glu(239), Asp(241), Glu(243), and Trp(244)).	Aspartic Acid	324-327	calreticulin	Homo sapiens	123-135
16291754-5	2006	Bradykinin-dependent Ca2+ release from the endoplasmic reticulum was rescued by wild-type calreticulin and by the Glu(238), Glu(239), Asp(241), and Glu(243) mutants.	Aspartic Acid	134-137	kininogen 1	Homo sapiens	0-10
16291754-7	2006	We identified four amino acid residues (Glu(239), Asp(241), Glu(243), and Trp(244)) at the hairpin tip of the P-domain that are critical in the formation of a complex between ERp57 and calreticulin.	Aspartic Acid	50-53	protein disulfide isomerase family A member 3	Homo sapiens	175-180
16411775-0	2006	How gastric lipase, an interfacial enzyme with a Ser-His-Asp catalytic triad, acts optimally at acidic pH.	Aspartic Acid	57-60	lipase F, gastric type	Homo sapiens	4-18
16260050-3	2006	The fusion partner gene with 127 amino acid residues of the C-terminus from L-asparaginase was recombined respectively with asp-pro-pro-hGHRH(1-44), asp-pro-hGHRH(1-44) or asp-1pro-GHRH(2-44) genes synthesized by PCR method to form three kinds of fusion proteins with unique acid labile linker Asp-Pro.	Aspartic Acid	294-297	asparaginase and isoaspartyl peptidase 1	Homo sapiens	76-90
16301322-3	2006	The region 1-16 of Abeta can be considered the minimal zinc-binding domain and contains two aspartates subject to protein aging.	Aspartic Acid	92-102	amyloid beta precursor protein	Homo sapiens	19-24
16638323-9	2006	Only nine aspartic acid substitution in type I collagen has been fully reported in the world.	Aspartic Acid	10-23	collagen type I alpha 1 chain	Homo sapiens	40-46
16638323-9	2006	Only nine aspartic acid substitution in type I collagen has been fully reported in the world.	Aspartic Acid	10-23	collagen type I alpha 1 chain	Homo sapiens	47-55
16638323-11	2006	Since only few of nucleotide changes in type I collagen glycine codons would result in an aspartic acid substitution, these are predicted to be infrequent.	Aspartic Acid	90-103	collagen type I alpha 1 chain	Homo sapiens	40-46
16638323-11	2006	Since only few of nucleotide changes in type I collagen glycine codons would result in an aspartic acid substitution, these are predicted to be infrequent.	Aspartic Acid	90-103	collagen type I alpha 1 chain	Homo sapiens	47-55
16286459-2	2006	The metal ion dependence of ADAMTS13 activity was examined with multimeric VWF and a fluorescent peptide substrate based on Asp(1596)-Arg(1668) of the VWF A2 domain, FRETS-VWF73.	Aspartic Acid	124-127	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	28-36
16286478-7	2006	The mutant VEGFR-1 (Asp(1050)) promoted endothelial cell proliferation but not tubulogenesis.	Aspartic Acid	20-23	fms related receptor tyrosine kinase 1	Homo sapiens	11-18
16278211-8	2006	Critical vicinal acidic amino acids in ARH3, identified by mutagenesis (Asp(77) and Asp(78)), are located in a region similar to that required for activity in ARH1 but different from the location of the critical vicinal glutamates in the PARG catalytic site.	Aspartic Acid	84-87	ADP-ribosylserine hydrolase	Homo sapiens	39-43
16286478-9	2006	Furthermore, mutation of the invariable aspartic acid to asparagine in VEGFR-2 lowered the autophosphorylation of activation loop tyrosines 1052 and 1057.	Aspartic Acid	40-53	kinase insert domain receptor	Homo sapiens	71-78
16125835-8	2006	Sites in the mammalian PDK1 corresponding to Asp-167 and Thr-211 are essential for PDK1 autophosphorylation and activity.	Aspartic Acid	45-48	3-phosphoinositide dependent protein kinase 1	Homo sapiens	23-27
16374775-1	2006	In the present work, RGDS (Arg-Gly-Asp-Ser) was immobilized on PLLA scaffolds with plasma treatment.	Aspartic Acid	35-38	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	21-25
16475710-3	2006	The mutant alleles of CYP2C9 were residue 144 (Arg (*1)/Cys (*2)), residue 358 (Tyr/Cys), residue 359 (Ile/Leu (*3)) and residue 417 (Gly/Asp).	Aspartic Acid	138-141	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	22-28
16542493-0	2006	Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians.	Aspartic Acid	44-57	asporin	Homo sapiens	74-81
16542493-2	2006	Alleles of this microsatellite determine the variable number of aspartic acid residues in the amino-terminal end of the asporin protein.	Aspartic Acid	64-77	asporin	Homo sapiens	120-127
16542493-4	2006	The OA-associated allele, with 14 aspartic acid residues, inhibits the anabolic effects of transforming growth factor beta more strongly than other asporin alleles, leading to increased OA liability.	Aspartic Acid	34-47	transforming growth factor beta 1	Homo sapiens	91-122
16542493-8	2006	Our results, together with reports from the United Kingdom and Greece, indicate that the stretch of aspartic acid residues in asporin is not an important factor in OA susceptibility among European Caucasians.	Aspartic Acid	100-113	asporin	Homo sapiens	126-133
16376335-4	2006	The effects of phosphorylation of hPrxI on its protein structure and dual functions were determined using site-directed mutagenesis, in which the phosphorylation site was substituted with aspartate to mimic the phosphorylated status of the protein (T90D-hPrxI).	Aspartic Acid	188-197	peroxiredoxin 1	Homo sapiens	34-39
16125835-7	2006	Other identified sites of importance for autophosphorylation and/or activity of AtPDK1 were Asp-167, Thr-176, and Thr-211.	Aspartic Acid	92-95	3'-phosphoinositide-dependent protein kinase 1	Arabidopsis thaliana	80-86
16125835-8	2006	Sites in the mammalian PDK1 corresponding to Asp-167 and Thr-211 are essential for PDK1 autophosphorylation and activity.	Aspartic Acid	45-48	3-phosphoinositide dependent protein kinase 1	Homo sapiens	83-87
16125835-11	2006	Our data clearly show that Asp-167, Thr-176, Ser-177, Thr-211, and Ser-276 in AtPDK1 are important for the downstream phosphorylation of AtS6k2.	Aspartic Acid	27-30	3'-phosphoinositide-dependent protein kinase 1	Arabidopsis thaliana	78-84
16125835-11	2006	Our data clearly show that Asp-167, Thr-176, Ser-177, Thr-211, and Ser-276 in AtPDK1 are important for the downstream phosphorylation of AtS6k2.	Aspartic Acid	27-30	serine/threonine protein kinase 2	Arabidopsis thaliana	137-143
16719801-4	2006	The NA active site is highly polar and formed mostly by arginine, aspartate and glutamate residues.	Aspartic Acid	66-75	neuraminidase 1	Homo sapiens	4-6
16454727-4	2006	Thrombin, factor Xa, tissue factor/factor VIIa and platelet GPIIb/IIIa receptors display a preference for molecules containing highly basic arginine and/or acidic aspartate moieties, which are, however, associated with poor bioavailability after oral application.	Aspartic Acid	163-172	coagulation factor II, thrombin	Homo sapiens	0-8
16454727-4	2006	Thrombin, factor Xa, tissue factor/factor VIIa and platelet GPIIb/IIIa receptors display a preference for molecules containing highly basic arginine and/or acidic aspartate moieties, which are, however, associated with poor bioavailability after oral application.	Aspartic Acid	163-172	coagulation factor X	Homo sapiens	10-19
16454727-4	2006	Thrombin, factor Xa, tissue factor/factor VIIa and platelet GPIIb/IIIa receptors display a preference for molecules containing highly basic arginine and/or acidic aspartate moieties, which are, however, associated with poor bioavailability after oral application.	Aspartic Acid	163-172	integrin subunit alpha 2b	Homo sapiens	60-65
16918475-5	2006	The determination of the X-ray crystal structure of NAT from Salmonella typhimurium led to the identification of the catalytically essential triad of residues: Cys-His-Asp, which is present in all functional NAT enzymes.	Aspartic Acid	168-171	bromodomain containing 2	Homo sapiens	52-55
16918475-5	2006	The determination of the X-ray crystal structure of NAT from Salmonella typhimurium led to the identification of the catalytically essential triad of residues: Cys-His-Asp, which is present in all functional NAT enzymes.	Aspartic Acid	168-171	bromodomain containing 2	Homo sapiens	208-211
16420423-8	2006	In electrophysiological experiments with identified snail neurons, selective blockade of the caspase-3 with the irreversible and cell-permeable inhibitor of caspase-3 N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp-(OMe)-fluoro-methylketone prevented development of the long-term stage of synaptic input sensitization, suggesting that caspase is necessary for normal synaptic plasticity in snails.	Aspartic Acid	187-190	caspase 3	Homo sapiens	93-102
16420423-8	2006	In electrophysiological experiments with identified snail neurons, selective blockade of the caspase-3 with the irreversible and cell-permeable inhibitor of caspase-3 N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp-(OMe)-fluoro-methylketone prevented development of the long-term stage of synaptic input sensitization, suggesting that caspase is necessary for normal synaptic plasticity in snails.	Aspartic Acid	187-190	caspase 3	Homo sapiens	157-166
16403013-8	2006	The latter subfamily comprises most GYF domains and is characterized by a shorter beta(1)-beta(2) loop and an aspartate instead of the tryptophan found at position 8 in CD2BP2-type GYF domains.	Aspartic Acid	110-119	CD2 cytoplasmic tail binding protein 2	Homo sapiens	169-175
16403016-6	2006	It is shown that chemical cleavage at aspartate residues in the protease resistant RNase A, followed by tryptic digestion can be optimized so that the rigid protein breaks up into MALDI-MS detectable fragments, leaving the disulfide bonds intact.	Aspartic Acid	38-47	ribonuclease A family member 1, pancreatic	Homo sapiens	83-90
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Aspartic Acid	134-137	tumor necrosis factor	Homo sapiens	13-16
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Aspartic Acid	134-137	tumor necrosis factor	Homo sapiens	51-54
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Aspartic Acid	134-137	tumor necrosis factor	Homo sapiens	166-175
16343275-5	2006	Subsequent analyses demonstrated that observed atypical "HbA2" was, in fact, a rare innocuous alpha-globin variant, called Hb Woodville [alpha 2 6(A4); Asp --> Tyr].	Aspartic Acid	152-155	hemoglobin subunit alpha 2	Homo sapiens	57-61
16343275-5	2006	Subsequent analyses demonstrated that observed atypical "HbA2" was, in fact, a rare innocuous alpha-globin variant, called Hb Woodville [alpha 2 6(A4); Asp --> Tyr].	Aspartic Acid	152-155	hemoglobin subunit alpha 2	Homo sapiens	94-106
20141508-5	2006	This is achieved either by directly coordinating to the metal ion found in some metalloenzymes (CAs, CPA, STS), usually by means of one of the nitrogen atoms present in the sulfamide motif, or, as in the case of the cyclic sulfamides, acting as HIV protease inhibitors interacting with the catalytically critical aspartic acid residues of the active site by means of an oxygen atom belonging to the HN-SO(2)-NH motif that substitutes a catalytically essential water molecule.	Aspartic Acid	313-326	carboxypeptidase A1	Homo sapiens	101-104
16118184-3	2006	Cells containing a phosphomimetic version of RPA generated by mutation of this serine to aspartate exhibit a significant alteration in the pattern of meiotic crossovers for specific genetic intervals.	Aspartic Acid	89-98	replication protein A1	Mus musculus	45-48
16352457-2	2006	Host molecule tryptophan-aspartate containing coat protein (TACO) has been shown to play a crucial role in the arrest of such a maturation process.	Aspartic Acid	25-34	coronin 1A	Homo sapiens	60-64
17717965-8	2006	Native or pegylated L-asparaginase (ASNase or PEG-ASNase) are highly specific for the deamination of L-asparagine (Asn) to aspartic acid and ammonia.	Aspartic Acid	123-136	asparaginase and isoaspartyl peptidase 1	Homo sapiens	20-34
16355270-17	2006	Conversely, FHL2 stimulation of CREB activity was dependent on integrin function because it was inhibited by Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.	Aspartic Acid	121-124	four and a half LIM domains 2	Mus musculus	12-16
16355270-17	2006	Conversely, FHL2 stimulation of CREB activity was dependent on integrin function because it was inhibited by Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.	Aspartic Acid	121-124	cAMP responsive element binding protein 1	Mus musculus	32-36
16406883-7	2006	When APE1 and XRCC1 polymorphisms were evaluated together, we found an increased risk of the XRCC1(399Arg/Gln+Gln/Gln)/APE1(51Gln/Gln) (OR 4.0, 95% CI 1.3 to 12.5) and XRCC1(399Arg/Gln+Gln/Gln)/APE1(148Asp/Asp) (OR 2.9, 95% CI 1.4 to 6.1) genotypes in white men.	Aspartic Acid	202-205	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	5-9
16311710-2	2006	We recently found that an aspartic-acid repeat polymorphism of the asporin gene (ASPN) on chromosome 9 is associated with susceptibility to OA in Japanese.	Aspartic Acid	26-39	asporin	Homo sapiens	67-74
16311710-2	2006	We recently found that an aspartic-acid repeat polymorphism of the asporin gene (ASPN) on chromosome 9 is associated with susceptibility to OA in Japanese.	Aspartic Acid	26-39	asporin	Homo sapiens	81-85
17192674-4	2006	The atypical variant was later found to have a single-amino-acid mutation at Asp-70 (McGuire et al., 1989), which decreased the affinity of BChE for all positively charged compounds.	Aspartic Acid	77-80	butyrylcholinesterase	Homo sapiens	140-144
16191480-3	2006	Asp-351 and Leu-536 participate in hydrogen bond (Asp-351) and hydrophobic (Leu-536) interactions at the start of helix 12 in the ligand-binding domain (LBD) of the ERalpha.	Aspartic Acid	0-3	estrogen receptor 1	Homo sapiens	165-172
16191480-3	2006	Asp-351 and Leu-536 participate in hydrogen bond (Asp-351) and hydrophobic (Leu-536) interactions at the start of helix 12 in the ligand-binding domain (LBD) of the ERalpha.	Aspartic Acid	50-53	estrogen receptor 1	Homo sapiens	165-172
16406883-7	2006	When APE1 and XRCC1 polymorphisms were evaluated together, we found an increased risk of the XRCC1(399Arg/Gln+Gln/Gln)/APE1(51Gln/Gln) (OR 4.0, 95% CI 1.3 to 12.5) and XRCC1(399Arg/Gln+Gln/Gln)/APE1(148Asp/Asp) (OR 2.9, 95% CI 1.4 to 6.1) genotypes in white men.	Aspartic Acid	202-205	X-ray repair cross complementing 1	Homo sapiens	14-19
16406883-7	2006	When APE1 and XRCC1 polymorphisms were evaluated together, we found an increased risk of the XRCC1(399Arg/Gln+Gln/Gln)/APE1(51Gln/Gln) (OR 4.0, 95% CI 1.3 to 12.5) and XRCC1(399Arg/Gln+Gln/Gln)/APE1(148Asp/Asp) (OR 2.9, 95% CI 1.4 to 6.1) genotypes in white men.	Aspartic Acid	202-205	X-ray repair cross complementing 1	Homo sapiens	93-98
16406883-7	2006	When APE1 and XRCC1 polymorphisms were evaluated together, we found an increased risk of the XRCC1(399Arg/Gln+Gln/Gln)/APE1(51Gln/Gln) (OR 4.0, 95% CI 1.3 to 12.5) and XRCC1(399Arg/Gln+Gln/Gln)/APE1(148Asp/Asp) (OR 2.9, 95% CI 1.4 to 6.1) genotypes in white men.	Aspartic Acid	202-205	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	119-123
16406883-7	2006	When APE1 and XRCC1 polymorphisms were evaluated together, we found an increased risk of the XRCC1(399Arg/Gln+Gln/Gln)/APE1(51Gln/Gln) (OR 4.0, 95% CI 1.3 to 12.5) and XRCC1(399Arg/Gln+Gln/Gln)/APE1(148Asp/Asp) (OR 2.9, 95% CI 1.4 to 6.1) genotypes in white men.	Aspartic Acid	202-205	X-ray repair cross complementing 1	Homo sapiens	93-98
16406883-7	2006	When APE1 and XRCC1 polymorphisms were evaluated together, we found an increased risk of the XRCC1(399Arg/Gln+Gln/Gln)/APE1(51Gln/Gln) (OR 4.0, 95% CI 1.3 to 12.5) and XRCC1(399Arg/Gln+Gln/Gln)/APE1(148Asp/Asp) (OR 2.9, 95% CI 1.4 to 6.1) genotypes in white men.	Aspartic Acid	202-205	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	119-123
16328052-4	2006	rHAUSP cDNA encodes 3,312 bp and 1,103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains characteristic of the ubiquitin-specific processing proteases.	Aspartic Acid	133-136	ubiquitin specific peptidase 7	Rattus norvegicus	0-6
16517089-10	2006	The potential regulatory role of CBP/p300-interacting transactivators with glutamic acid/aspartic acid-rich carboxyl-terminal domain in the transcription of genes like TGF-alpha implicates the protein in diurnal activity rhythms.	Aspartic Acid	89-102	transforming growth factor alpha	Mus musculus	168-177
18175625-19	2006	A molecular study of the neoplastic tissue evidenced a typical mutation of the K-ras gene codon 12: the normal sequence GGT (glycine) was altered into GAT (aspartic acid).	Aspartic Acid	156-169	KRAS proto-oncogene, GTPase	Homo sapiens	79-84
17116467-3	2006	The deglycosylation reaction by PNGase brings about two major changes on substrate proteins; one is a removal of N-glycan chains, and the other is the introduction of negative charge(s) into the core peptide by converting glycosylated asparagine residue(s) into aspartic acid residue(s).	Aspartic Acid	262-275	N-glycanase 1	Homo sapiens	32-38
16533566-3	2006	Here we show for the first time the functional impact of one of the two highly conserved clusters of six negatively charged glutamates and aspartate (802-807; poly ED motif) at the II-III loop of the alpha 1 subunits of rabbit of Ca(v)1.2, alpha(1)1.2 and alpha(1)1.2 DeltaN60-Delta1733) on voltage-dependent inactivation.	Aspartic Acid	139-148	caveolin-1	Oryctolagus cuniculus	230-236
16328052-4	2006	rHAUSP cDNA encodes 3,312 bp and 1,103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains characteristic of the ubiquitin-specific processing proteases.	Aspartic Acid	155-158	ubiquitin specific peptidase 7	Rattus norvegicus	0-6
16129618-2	2006	The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately.	Aspartic Acid	196-209	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-58
16129618-2	2006	The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately.	Aspartic Acid	196-209	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
16129618-2	2006	The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately.	Aspartic Acid	211-215	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-58
16129618-2	2006	The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately.	Aspartic Acid	211-215	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
16186124-4	2005	Like other 2OG oxygenases, PAHX possesses a double-stranded beta-helix core, which supports three iron binding ligands (His(175), Asp(177), and His(264)); the 2-oxoacid group of 2OG binds to the Fe(II) in a bidentate manner.	Aspartic Acid	130-133	phytanoyl-CoA 2-hydroxylase	Homo sapiens	27-31
16892900-2	2006	L-asparaginase leads to enzymatic cleavage of L-asparagine (amino acid essential for lymphoblasts" growth) to ammonia and L-aspartic acid, what results in depletion of L-asparagine in a serum and cerebrospinal fluid, and finally leads to destruction of lymphoblasts, which lack ability of endogenic L-asparagine production.	Aspartic Acid	122-137	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
16352739-2	2005	Mastocytosis is often associated with a somatic point mutation in the Kit protooncogene leading to an Asp/Val substitution at position 816 in the kinase domain of this receptor.	Aspartic Acid	102-105	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-73
16288713-5	2005	PERK, an eIF2alpha kinase, is found to interact with wt and mutants of eIF2alpha in which the serine 51 or 48 residue is replaced by alanine or aspartic acid thereby suggesting that the phosphorylation site in the substrate is not important for interaction.	Aspartic Acid	144-157	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	0-4
16288713-5	2005	PERK, an eIF2alpha kinase, is found to interact with wt and mutants of eIF2alpha in which the serine 51 or 48 residue is replaced by alanine or aspartic acid thereby suggesting that the phosphorylation site in the substrate is not important for interaction.	Aspartic Acid	144-157	eukaryotic translation initiation factor 2A	Homo sapiens	9-18
16288713-5	2005	PERK, an eIF2alpha kinase, is found to interact with wt and mutants of eIF2alpha in which the serine 51 or 48 residue is replaced by alanine or aspartic acid thereby suggesting that the phosphorylation site in the substrate is not important for interaction.	Aspartic Acid	144-157	eukaryotic translation initiation factor 2A	Homo sapiens	71-80
16251193-4	2005	The presence of Asp-948 at the P1 position inactivated the corresponding site (ALRRLLD948-L949FGD) in murine pericentrin.	Aspartic Acid	16-19	pericentrin (kendrin)	Mus musculus	109-120
16186124-6	2005	Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)).	Aspartic Acid	146-149	phytanoyl-CoA 2-hydroxylase	Homo sapiens	10-14
16252083-5	2005	We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --&gt; G transition at 127 position producing an Asn --&gt; Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --&gt; A transition at 1032 position resulting in a Gly --&gt; Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression.	Aspartic Acid	298-301	mutS homolog 2	Homo sapiens	91-96
16154610-5	2005	Phosphorylation-mimicking aspartic acid mutations rendered p33 nonfunctional in plant protoplasts and in yeast, a model host.	Aspartic Acid	26-39	inhibitor of growth family member 1	Homo sapiens	59-62
16511245-2	2005	However, the products of the two alleles differ by only two amino acids, at heavy-chain residues 114 (His in HLA-B*2704; Asp in HLA-B*2706) and 116 (Asp in HLA-B*2704; Tyr in HLA-B*2706).	Aspartic Acid	121-124	major histocompatibility complex, class I, B	Homo sapiens	128-133
16511245-2	2005	However, the products of the two alleles differ by only two amino acids, at heavy-chain residues 114 (His in HLA-B*2704; Asp in HLA-B*2706) and 116 (Asp in HLA-B*2704; Tyr in HLA-B*2706).	Aspartic Acid	121-124	major histocompatibility complex, class I, B	Homo sapiens	128-133
16511245-2	2005	However, the products of the two alleles differ by only two amino acids, at heavy-chain residues 114 (His in HLA-B*2704; Asp in HLA-B*2706) and 116 (Asp in HLA-B*2704; Tyr in HLA-B*2706).	Aspartic Acid	121-124	major histocompatibility complex, class I, B	Homo sapiens	128-133
16229820-3	2005	We first randomly mutated three Asp residues (D176, D210, and D211) that constitute the S2 pocket of Kex2 and then isolated from the resulting library Kex2 variants that preferred substrates with Met (poorly preferred by wild type Kex2) at the P2 position using a yeast-based screening method.	Aspartic Acid	32-35	kexin KEX2	Saccharomyces cerevisiae S288C	101-105
16160139-4	2005	We confirm that the interaction of RGS3 with 14-3-3tau and 14-3-3zeta requires Ser264 and not the RGS domain and show both that mutation of the conserved RGS domain serine, Ser496 in RGS3, to either alanine or aspartate does not prevent binding of 14-3-3 proteins and that 14-3-3 proteins do not inhibit GTPase-activating protein (GAP) activity against receptor-activated Galpha(o1).	Aspartic Acid	210-219	regulator of G protein signaling 3	Homo sapiens	35-39
16955734-1	2005	The activities of malate-aspartate shuttle enzymes viz., cytosolic and mitochondrial aspartate aminotransferase (c- and m-AsAT) and malate dehydrogenase (c- and m-MDH) were measured in liver and kidney of ad libitum (AL) and dietary-restricted (DR) mice and also on triiodothyronine (T3) treatment.	Aspartic Acid	25-34	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	71-111
16316977-8	2005	Substitution of the lysine by serine or aspartate abolished the "open-lock" characteristic and converted AKT2 into an inward-rectifying channel.	Aspartic Acid	40-49	potassium transport 2/3	Arabidopsis thaliana	105-109
16361827-5	2005	We analyzed the AQP2 gene and detected a compound heterozygous missense point mutation: 70Ala (GCC) to Asp (GAC) in exon 1 inherited from her father and 187Arg (CGC) to His (CAC) in exon 3 inherited from her mother.	Aspartic Acid	103-106	aquaporin 2	Homo sapiens	16-20
16361827-5	2005	We analyzed the AQP2 gene and detected a compound heterozygous missense point mutation: 70Ala (GCC) to Asp (GAC) in exon 1 inherited from her father and 187Arg (CGC) to His (CAC) in exon 3 inherited from her mother.	Aspartic Acid	103-106	guanylate cyclase 2C	Homo sapiens	95-98
16361827-7	2005	This is the first report to characterize AQP2 mutations in Korean patients with autosomal recessive CNDI, and expands the spectrum of AQP2 mutations by reporting two novel mutation, 70Ala (GCC) to Asp (GAC) and 187Arg (CGC) to His (CAC).	Aspartic Acid	197-200	aquaporin 2	Homo sapiens	134-138
16361827-7	2005	This is the first report to characterize AQP2 mutations in Korean patients with autosomal recessive CNDI, and expands the spectrum of AQP2 mutations by reporting two novel mutation, 70Ala (GCC) to Asp (GAC) and 187Arg (CGC) to His (CAC).	Aspartic Acid	197-200	guanylate cyclase 2C	Homo sapiens	189-192
16326832-0	2005	Role of aspartate 351 in transactivation and active conformation of estrogen receptor alpha.	Aspartic Acid	8-17	estrogen receptor 1	Homo sapiens	68-91
16326832-6	2005	Furthermore Asp-351 was required not only for the estrogen-dependent conformational change of wild-type ERalpha but also for the constitutive transcriptional activity and ligand-independent active conformation of ERalpha mutant Y537N.	Aspartic Acid	12-15	estrogen receptor 1	Homo sapiens	104-111
16326832-6	2005	Furthermore Asp-351 was required not only for the estrogen-dependent conformational change of wild-type ERalpha but also for the constitutive transcriptional activity and ligand-independent active conformation of ERalpha mutant Y537N.	Aspartic Acid	12-15	estrogen receptor 1	Homo sapiens	213-220
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Aspartic Acid	104-107	estrogen related receptor gamma	Homo sapiens	49-76
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Aspartic Acid	104-107	estrogen related receptor gamma	Homo sapiens	78-82
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Aspartic Acid	104-107	estrogen receptor 1	Homo sapiens	156-163
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Aspartic Acid	104-107	estrogen related receptor gamma	Homo sapiens	228-232
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Aspartic Acid	104-107	MYB binding protein 1a	Homo sapiens	330-334
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Aspartic Acid	145-148	estrogen related receptor gamma	Homo sapiens	49-76
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Aspartic Acid	145-148	estrogen related receptor gamma	Homo sapiens	78-82
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Aspartic Acid	145-148	estrogen receptor 1	Homo sapiens	156-163
16326832-8	2005	These data suggest a role of Asp-351 in inducing and stabilizing the active conformation of ERalpha, and our results experimentally confirm the concept that Asp-351 in helix 3 interacts with the amide hydrogen of L540 in helix 12 to form a transcriptionally competent surface for binding p160 coactivators.	Aspartic Acid	29-32	estrogen receptor 1	Homo sapiens	92-99
16326832-8	2005	These data suggest a role of Asp-351 in inducing and stabilizing the active conformation of ERalpha, and our results experimentally confirm the concept that Asp-351 in helix 3 interacts with the amide hydrogen of L540 in helix 12 to form a transcriptionally competent surface for binding p160 coactivators.	Aspartic Acid	157-160	estrogen receptor 1	Homo sapiens	92-99
16326832-8	2005	These data suggest a role of Asp-351 in inducing and stabilizing the active conformation of ERalpha, and our results experimentally confirm the concept that Asp-351 in helix 3 interacts with the amide hydrogen of L540 in helix 12 to form a transcriptionally competent surface for binding p160 coactivators.	Aspartic Acid	157-160	MYB binding protein 1a	Homo sapiens	288-292
16160139-4	2005	We confirm that the interaction of RGS3 with 14-3-3tau and 14-3-3zeta requires Ser264 and not the RGS domain and show both that mutation of the conserved RGS domain serine, Ser496 in RGS3, to either alanine or aspartate does not prevent binding of 14-3-3 proteins and that 14-3-3 proteins do not inhibit GTPase-activating protein (GAP) activity against receptor-activated Galpha(o1).	Aspartic Acid	210-219	paired like homeodomain 2	Homo sapiens	35-38
16160139-4	2005	We confirm that the interaction of RGS3 with 14-3-3tau and 14-3-3zeta requires Ser264 and not the RGS domain and show both that mutation of the conserved RGS domain serine, Ser496 in RGS3, to either alanine or aspartate does not prevent binding of 14-3-3 proteins and that 14-3-3 proteins do not inhibit GTPase-activating protein (GAP) activity against receptor-activated Galpha(o1).	Aspartic Acid	210-219	regulator of G protein signaling 3	Homo sapiens	183-187
16162500-9	2005	For example, within the catalytic region an aspartate in Mnk2 plays a key role.	Aspartic Acid	44-53	MAPK interacting serine/threonine kinase 2	Homo sapiens	57-61
16162505-2	2005	We have previously shown that Phe(120), Glu(216), and Asp(301) in the active site of cytochrome P450 2D6 (CYP2D6) play a key role in substrate recognition by this important drug-metabolizing enzyme (Paine, M. J., McLaughlin, L. A., Flanagan, J. U., Kemp, C. A., Sutcliffe, M. J., Roberts, G. C., and Wolf, C. R. (2003) J. Biol.	Aspartic Acid	54-57	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	85-104
16162505-2	2005	We have previously shown that Phe(120), Glu(216), and Asp(301) in the active site of cytochrome P450 2D6 (CYP2D6) play a key role in substrate recognition by this important drug-metabolizing enzyme (Paine, M. J., McLaughlin, L. A., Flanagan, J. U., Kemp, C. A., Sutcliffe, M. J., Roberts, G. C., and Wolf, C. R. (2003) J. Biol.	Aspartic Acid	54-57	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	106-112
16237719-6	2005	In cortex, striatum, and hippocampus of male AQP4-knockout mice, an increase of glutamine and decrease of aspartate were observed.	Aspartic Acid	106-115	aquaporin 4	Mus musculus	45-49
16123039-0	2005	Endoplasmic reticulum retention and associated degradation of a GABAA receptor epilepsy mutation that inserts an aspartate in the M3 transmembrane segment of the alpha1 subunit.	Aspartic Acid	113-122	adrenoceptor alpha 1D	Homo sapiens	162-168
16123039-1	2005	A GABA(A) receptor alpha1 subunit epilepsy mutation (alpha1(A322D)) introduces a negatively charged aspartate residue into the hydrophobic M3 transmembrane domain of the alpha1 subunit.	Aspartic Acid	100-109	adrenoceptor alpha 1D	Homo sapiens	19-25
16123039-1	2005	A GABA(A) receptor alpha1 subunit epilepsy mutation (alpha1(A322D)) introduces a negatively charged aspartate residue into the hydrophobic M3 transmembrane domain of the alpha1 subunit.	Aspartic Acid	100-109	adrenoceptor alpha 1D	Homo sapiens	19-24
16123039-1	2005	A GABA(A) receptor alpha1 subunit epilepsy mutation (alpha1(A322D)) introduces a negatively charged aspartate residue into the hydrophobic M3 transmembrane domain of the alpha1 subunit.	Aspartic Acid	100-109	adrenoceptor alpha 1D	Homo sapiens	53-59
16049677-11	2005	Together with our previous studies, the results: (1) allow a model to be formulated regarding the coordinate allosteric control of PKc and phosphoenolpyruvate carboxylase by aspartate and glutamate in developing COS, and (2) provide further biochemical evidence that castor plant PKc exists as tissue-specific isozymes that exhibit substantial differences in their respective physical and regulatory properties.	Aspartic Acid	174-183	phosphoenolpyruvate carboxylase, housekeeping isozyme	Glycine max	139-170
15998642-0	2005	Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.	Aspartic Acid	59-68	signal peptide peptidase-like 2	Danio rerio	142-148
15998642-0	2005	Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.	Aspartic Acid	59-68	signal peptide peptidase 3	Danio rerio	153-158
16301179-3	2005	The phosphorylation is catalyzed by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activity, as a result of activation of NR2B-containing N-methyl-D-aspartate subtype of glutamate receptors (NMDARs) during ischemia.	Aspartic Acid	156-166	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	36-81
16301179-3	2005	The phosphorylation is catalyzed by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activity, as a result of activation of NR2B-containing N-methyl-D-aspartate subtype of glutamate receptors (NMDARs) during ischemia.	Aspartic Acid	156-166	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	83-89
16301179-3	2005	The phosphorylation is catalyzed by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activity, as a result of activation of NR2B-containing N-methyl-D-aspartate subtype of glutamate receptors (NMDARs) during ischemia.	Aspartic Acid	156-166	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	130-134
16165356-0	2005	Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2.	Aspartic Acid	74-87	solute carrier family 1 member 2	Homo sapiens	186-192
16165356-3	2005	In this study, we describe the synthesis and biological activities of novel aryl-ether, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT-2.	Aspartic Acid	110-123	solute carrier family 1 member 2	Homo sapiens	182-188
16272342-4	2005	Mutations Gly25 --&gt; Asp and Gly28 --&gt; Glu create comparable structural changes in rat MBL but the G28E variant activates complement &gt;10-fold less efficiently than the G25D variant, which in turn has approximately 7-fold lower activity than wild-type MBL.	Aspartic Acid	23-26	mannose binding lectin 2	Homo sapiens	92-95
16251276-1	2005	Every residue of the 101-aa Escherichia coli toxin CcdB was substituted with Ala, Asp, Glu, Lys, and Arg by using site-directed mutagenesis.	Aspartic Acid	82-85	hypothetical protein	Escherichia coli	51-55
16198425-6	2005	However, at P30, lower aspartate contents, in contrast with increased glutamate levels, were detected in all experimental groups.	Aspartic Acid	23-32	high mobility group box 1	Mus musculus	12-15
16251276-4	2005	At all buried positions, introduction of Asp results in an inactive phenotype at all CcdB transcriptional levels.	Aspartic Acid	41-44	hypothetical protein	Escherichia coli	85-89
16246054-2	2005	The N-terminus of Abeta is generated by cleavage of the Met-Asp bond at position 671-672 of APP (amyloid precursor protein), catalysed by a proteolytic activity called beta-secretase.	Aspartic Acid	60-63	amyloid beta precursor protein	Homo sapiens	18-23
16263864-0	2005	Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31.	Aspartic Acid	65-74	solute carrier family 25 member 12	Homo sapiens	93-101
15878772-4	2005	Gene analysis showed that homozygote missense mutation (204 Asp (GAC)-Glu (GAG)) exists in exon 5 of LPL gene.	Aspartic Acid	60-63	lipoprotein lipase	Homo sapiens	101-104
16246054-2	2005	The N-terminus of Abeta is generated by cleavage of the Met-Asp bond at position 671-672 of APP (amyloid precursor protein), catalysed by a proteolytic activity called beta-secretase.	Aspartic Acid	60-63	amyloid beta precursor protein	Homo sapiens	97-122
16272569-1	2005	A cyclic chimeric dodecapeptide (cCD) mimicking the conformation-specific domains of CCR5 and CXCR4 was prepared in which Gly-Asp links the amino and carboxyl termini of two combined pentapeptides (S169-G173 of CCR5; E179-R183 of CXCR4) derived from human immunodeficiency virus type-1 (HIV-1) coreceptors.	Aspartic Acid	126-129	chemokine (C-C motif) receptor 5	Mus musculus	85-89
16060860-0	2005	Endothelial nitric oxide synthase Glu(298)--&gt;Asp polymorphism, carotid atherosclerosis and intima-media thickness in a general population sample.	Aspartic Acid	48-51	nitric oxide synthase 3	Homo sapiens	0-33
16060860-1	2005	The Glu(298)--&gt;Asp (E298D; 894G--&gt;T) polymorphism of eNOS (endothelial nitric oxide synthase) has been related with cardiovascular disease.	Aspartic Acid	18-21	nitric oxide synthase 3	Homo sapiens	65-98
15972892-9	2005	Furthermore, Asp-103 has been identified as the key residue which mediates the effects of divalent cations on the binding properties of the CD-MPR.	Aspartic Acid	13-16	mannose-6-phosphate receptor, cation dependent	Homo sapiens	140-146
17191953-3	2005	We have analyzed sequence and structural diversity of sheep COX-1 and mouse COX-2 proteins by Active Site Profiling (ASP).	Aspartic Acid	117-120	cytochrome c oxidase subunit I	Ovis aries	60-65
17191953-3	2005	We have analyzed sequence and structural diversity of sheep COX-1 and mouse COX-2 proteins by Active Site Profiling (ASP).	Aspartic Acid	117-120	cytochrome c oxidase II, mitochondrial	Mus musculus	76-81
17191953-8	2005	ASP Analysis of human COX proteins suggests that some specificity determinants that distinguish COX-1 and COX-2 proteins are similar between sheep COX-1/mouse COX-2 and human COX-1/COX2; however, residue identities at those positions are not necessarily conserved.	Aspartic Acid	0-3	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	96-101
17191953-8	2005	ASP Analysis of human COX proteins suggests that some specificity determinants that distinguish COX-1 and COX-2 proteins are similar between sheep COX-1/mouse COX-2 and human COX-1/COX2; however, residue identities at those positions are not necessarily conserved.	Aspartic Acid	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
17191953-8	2005	ASP Analysis of human COX proteins suggests that some specificity determinants that distinguish COX-1 and COX-2 proteins are similar between sheep COX-1/mouse COX-2 and human COX-1/COX2; however, residue identities at those positions are not necessarily conserved.	Aspartic Acid	0-3	cytochrome c oxidase subunit I	Ovis aries	147-152
17191953-8	2005	ASP Analysis of human COX proteins suggests that some specificity determinants that distinguish COX-1 and COX-2 proteins are similar between sheep COX-1/mouse COX-2 and human COX-1/COX2; however, residue identities at those positions are not necessarily conserved.	Aspartic Acid	0-3	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	147-152
16242000-0	2005	CD117+ small cell lung cancer lacks the asp 816--&gt;val point mutation in exon 17.	Aspartic Acid	40-43	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
16272569-1	2005	A cyclic chimeric dodecapeptide (cCD) mimicking the conformation-specific domains of CCR5 and CXCR4 was prepared in which Gly-Asp links the amino and carboxyl termini of two combined pentapeptides (S169-G173 of CCR5; E179-R183 of CXCR4) derived from human immunodeficiency virus type-1 (HIV-1) coreceptors.	Aspartic Acid	126-129	chemokine (C-X-C motif) receptor 4	Mus musculus	94-99
16133265-0	2005	In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance.	Aspartic Acid	60-69	Tok1p	Saccharomyces cerevisiae S288C	32-37
16293771-10	2005	OPN significantly reduced the STZ-induced NO levels in the islets through an Arg-Gly-Asp (RGD)-dependent reduction of inducible NO synthase (iNOS) mRNA levels.	Aspartic Acid	85-88	secreted phosphoprotein 1	Rattus norvegicus	0-3
16293771-10	2005	OPN significantly reduced the STZ-induced NO levels in the islets through an Arg-Gly-Asp (RGD)-dependent reduction of inducible NO synthase (iNOS) mRNA levels.	Aspartic Acid	85-88	nitric oxide synthase 2	Rattus norvegicus	118-139
16293771-10	2005	OPN significantly reduced the STZ-induced NO levels in the islets through an Arg-Gly-Asp (RGD)-dependent reduction of inducible NO synthase (iNOS) mRNA levels.	Aspartic Acid	85-88	nitric oxide synthase 2	Rattus norvegicus	141-145
16106046-9	2005	We propose that one disulfide bond between C65 and C89 and free cysteine residues at C330 and C371 and the triad, serine-198, aspartic acid-360, and histidine-392, are required for the full expression of mLPLA2 activity.	Aspartic Acid	126-139	phospholipase A2, group XV	Mus musculus	204-210
16169022-4	2005	In acute hippocampal slices, photolysis of Ncm-D-aspartate by brief (1 ms) exposure to UV light elicited rapidly activating inward currents in astrocytes that were sensitive to inhibition by the glutamate transporter antagonist DL-threo-beta-benzyloxyaspartic acid (TBOA).	Aspartic Acid	49-58	CWC22 spliceosome associated protein homolog	Homo sapiens	43-46
16169022-7	2005	Photo-release of D-aspartate from Ncm-D-aspartate did not induce alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/kainate receptor or metabotropic glutamate receptor (mGluR) currents, but triggered robust NMDA receptor currents in neurons; Ncm-D-aspartate and the photolzyed caging group were similarly inert at NMDA receptors.	Aspartic Acid	19-28	CWC22 spliceosome associated protein homolog	Homo sapiens	34-37
16169022-8	2005	These results indicate that Ncm-D-aspartate can be used to study NMDA receptors at excitatory synapses and interactions between transporters and receptors in brain tissue.	Aspartic Acid	34-43	CWC22 spliceosome associated protein homolog	Homo sapiens	28-31
16183084-0	2005	The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3.	Aspartic Acid	16-25	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	136-141
16123041-6	2005	In apoptotic cell extracts, Claspin was cleaved by caspase-7 at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contain different functional domains.	Aspartic Acid	73-82	claspin	Homo sapiens	28-35
16123041-6	2005	In apoptotic cell extracts, Claspin was cleaved by caspase-7 at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contain different functional domains.	Aspartic Acid	73-82	caspase 7	Homo sapiens	51-60
15948716-5	2005	Nutritional analysis of the nce103 null mutant demonstrated that growth on glucose under a non-CO2-enriched nitrogen atmosphere was possible when the culture medium was provided with L-aspartate, fatty acids, uracil and L-argininine.	Aspartic Acid	183-194	carbonate dehydratase NCE103	Saccharomyces cerevisiae S288C	28-34
16217033-1	2005	The ATE1-encoded Arg-transferase mediates conjugation of Arg to N-terminal Asp, Glu, and Cys of certain eukaryotic proteins, yielding N-terminal Arg that can act as a degradation signal for the ubiquitin-dependent N-end rule pathway.	Aspartic Acid	75-78	arginyltransferase 1	Homo sapiens	4-8
16273652-8	2005	ICAM-1 genetic expression moved up after 1 h and reached its peak value after 9 h. CONCLUSION: MD plays an important role in ASP following acute lung injury (ALI).	Aspartic Acid	125-128	intercellular adhesion molecule 1	Rattus norvegicus	0-6
16232313-5	2005	The extremely accelerated rates in the rbcL phylogeny correlated with a shift from selection to mutation drift in codon usage of two-fold degenerate NNY codons comprising the amino acids asparagine, aspartate, histidine, phenylalanine, and tyrosine.	Aspartic Acid	199-208	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit	Cryptomonas paramecium	39-43
16096341-2	2005	The contribution of aspartate 298 (D298), an amino acid that links the transmembrane domain 2 (TM2) to the TM2-TM3 loop, in mouse 5-hydroxytryptamine(3A) (5-HT(3A)) receptor function was probed with site-directed mutagenesis in the present study.	Aspartic Acid	20-29	tropomyosin 1, alpha	Mus musculus	111-114
16096341-0	2005	Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+.	Aspartic Acid	8-17	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	31-37
16199199-7	2005	Citrin as a liver-type AGC plays a role in supplying aspartate to the cytosol for urea, protein and nucleotide synthesis by exchanging mitochondrial aspartate for cytosolic glutamate and proton, and transporting cytosolic NADH reducing equivalent to mitochondria as a member of malate aspartate shuttle essential for aerobic glycolysis.	Aspartic Acid	53-62	solute carrier family 25 member 13	Homo sapiens	0-6
20641210-7	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Aspartic Acid	44-47	vitronectin	Mus musculus	130-141
16511201-1	2005	The product of the human leukocyte antigen (HLA) gene HLA-B*2704 differs from that of the prototypical subtype HLA-B*2705 by three amino acids at heavy-chain residues 77 (Ser instead of Asp), 152 (Glu instead of Val) and 211 (Gly instead of Ala).	Aspartic Acid	186-189	major histocompatibility complex, class I, B	Homo sapiens	54-59
16081882-2	2005	Transfection studies with elastin cDNAs demonstrate that the glycine to aspartate change compromises the ability of the mutant protein to undergo normal elastin assembly.	Aspartic Acid	72-81	elastin	Homo sapiens	26-33
16081882-2	2005	Transfection studies with elastin cDNAs demonstrate that the glycine to aspartate change compromises the ability of the mutant protein to undergo normal elastin assembly.	Aspartic Acid	72-81	elastin	Homo sapiens	153-160
16076845-9	2005	Those N-terminal residues (Asp-103, Glu-109) contribute as much substrate-binding capability to ClpB as the conserved Tyr located at the entrance to the ClpB channel.	Aspartic Acid	27-30	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	96-100
16076845-9	2005	Those N-terminal residues (Asp-103, Glu-109) contribute as much substrate-binding capability to ClpB as the conserved Tyr located at the entrance to the ClpB channel.	Aspartic Acid	27-30	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	153-157
16222293-2	2005	Three amino (N)-terminal residues--aspartate, glutamate and cysteine--are arginylated by ATE1-encoded arginyl-transferases.	Aspartic Acid	35-44	arginyltransferase 1	Homo sapiens	89-93
16096279-6	2005	Similarly, when Ser730 was replaced by the phosphoserine mimetic, Asp, cleavage secretion of the resultant mutant remained susceptible to the enhancing effect of CaMI and PMA.	Aspartic Acid	66-69	calmodulin 1	Homo sapiens	162-166
15964901-4	2005	This study reports that bundles of DNA or F-actin formed after addition of histone H1 or lysozyme are efficiently dissolved by soluble multivalent anions such as polymeric aspartate or glutamate.	Aspartic Acid	172-181	H1.0 linker histone	Homo sapiens	75-85
16199199-0	2005	Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier.	Aspartic Acid	75-84	solute carrier family 25 member 13	Homo sapiens	40-46
16199199-1	2005	Citrin, encoded by SLC25A13, is a liver-type mitochondrial aspartate-glutamate carrier (AGC), of which deficiency, in autosomal recessive trait, causes neonatal intrahepatic cholestasis (NICCD) and adult-onset type II citrullinemia (CTLN2).	Aspartic Acid	59-68	solute carrier family 25 member 13	Homo sapiens	0-6
16199199-1	2005	Citrin, encoded by SLC25A13, is a liver-type mitochondrial aspartate-glutamate carrier (AGC), of which deficiency, in autosomal recessive trait, causes neonatal intrahepatic cholestasis (NICCD) and adult-onset type II citrullinemia (CTLN2).	Aspartic Acid	59-68	solute carrier family 25 member 13	Homo sapiens	19-27
16199199-7	2005	Citrin as a liver-type AGC plays a role in supplying aspartate to the cytosol for urea, protein and nucleotide synthesis by exchanging mitochondrial aspartate for cytosolic glutamate and proton, and transporting cytosolic NADH reducing equivalent to mitochondria as a member of malate aspartate shuttle essential for aerobic glycolysis.	Aspartic Acid	149-158	solute carrier family 25 member 13	Homo sapiens	0-6
16199199-12	2005	Loss of citrin first cause deficiency of aspartate in the cytosol, which results in an increase in cytosolic NADH/NAD(+) ratio and then activation of fatty acid synthesis pathway to compensate the aberrant ratio.	Aspartic Acid	41-50	solute carrier family 25 member 13	Homo sapiens	8-14
16095614-9	2005	Exchange of a highly conserved serine next to the nuclear localization signal by aspartate, which may mimic phosphorylation, resulted in a decreased nuclear import (SPL8), while DNA binding in vitro was abolished completely.	Aspartic Acid	81-90	squamosa promoter binding protein-like 8	Arabidopsis thaliana	165-169
16169958-7	2005	By contrast, p107 phosphorylation increased PEPC2"s K(m)(PEP) and sensitivity to malate, glutamic acid, and aspartic acid inhibition.	Aspartic Acid	108-121	RB transcriptional corepressor like 1	Homo sapiens	13-17
16091285-1	2005	The effects of d-amino acids at Asp(23) and Ser(26) residues on the conformational preference of beta-amyloid (Abeta) peptide fragment (Abeta(20-29)) have been studied using different spectroscopic techniques, namely vibrational circular dichroism (VCD), vibrational absorption, and electronic circular dichroism.	Aspartic Acid	32-35	amyloid beta precursor protein	Homo sapiens	97-117
16150047-4	2005	To the C-terminal part of recombinant staphylokinase (r-SAK), which is a promising profibrinolytic agent, we assembled: (i) the Kringle 2 domain (K2) of tissue-type plasminogen activator (t-PA), containing a fibrin-specific binding site, (ii) the RGD sequence (Arg-Gly-Asp) for the prevention of platelet aggregation and (iii) the antithrombotic agent - hirudin.	Aspartic Acid	269-272	plasminogen activator, tissue type	Homo sapiens	153-186
16171401-9	2005	In Mad1, this position corresponds to residue Asp 112.	Aspartic Acid	46-49	MAX dimerization protein 1	Homo sapiens	3-7
16171401-12	2005	Our results suggest that Asp 112 is implicated in the destabilization of Mad1 b-HLH-LZ homodimer.	Aspartic Acid	25-28	MAX dimerization protein 1	Homo sapiens	73-77
16171401-14	2005	This clearly suggests that Asp 112 plays a crucial role in the molecular recognition between Max and Mad1.	Aspartic Acid	27-30	MAX dimerization protein 1	Homo sapiens	101-105
15975984-2	2005	To identify specific Cd(2+)-binding sites on the hERG channel, we mutated potential Cd(2+)-coordination residues located in the transmembrane domains or extracellular loops linking these domains, including five Cys, three His, nine Asp and eight Glu residues.	Aspartic Acid	232-235	ETS transcription factor ERG	Homo sapiens	49-53
16164743-2	2005	In humans, a common polymorphism exists in the eNOS gene that results in the conversion of glutamate to aspartate for codon 298.	Aspartic Acid	104-113	nitric oxide synthase 3	Homo sapiens	47-51
15975984-9	2005	Extracellular Cd(2+) modulates hERG channel activation by binding to a coordination site formed, at least in part, by three Asp residues.	Aspartic Acid	124-127	ETS transcription factor ERG	Homo sapiens	31-35
16061254-8	2005	In addition, Pro193 of SLP-76 assists in positioning Arg192 into the compass pocket of PLCgamma1-SH3, which coordinates the compass residue through an unusual aspartate.	Aspartic Acid	159-168	lymphocyte cytosolic protein 2	Homo sapiens	23-29
16135563-8	2005	Based on site-directed mutagenesis studies, 5-LO is cleaved by casp-6 after Asp-170, which in a homology-based 3D model of 5-LO is located on the enzyme periphery.	Aspartic Acid	76-79	arachidonate 5-lipoxygenase	Homo sapiens	44-48
16135563-8	2005	Based on site-directed mutagenesis studies, 5-LO is cleaved by casp-6 after Asp-170, which in a homology-based 3D model of 5-LO is located on the enzyme periphery.	Aspartic Acid	76-79	caspase 6	Homo sapiens	63-69
16135563-8	2005	Based on site-directed mutagenesis studies, 5-LO is cleaved by casp-6 after Asp-170, which in a homology-based 3D model of 5-LO is located on the enzyme periphery.	Aspartic Acid	76-79	arachidonate 5-lipoxygenase	Homo sapiens	123-127
16061254-8	2005	In addition, Pro193 of SLP-76 assists in positioning Arg192 into the compass pocket of PLCgamma1-SH3, which coordinates the compass residue through an unusual aspartate.	Aspartic Acid	159-168	phospholipase C gamma 1	Homo sapiens	87-96
16164993-2	2005	This paralog of glutamyl-tRNA synthetases, the YadB protein, activates glutamate in the absence of tRNA and transfers the activated glutamate not on tRNA(Glu) but instead on tRNA(Asp).	Aspartic Acid	179-182	hypothetical protein	Escherichia coli	47-51
16147988-3	2005	The ssu71-1 and ssu71-2 alleles were cloned and found to encode single amino acid replacements of glycine-363, either glycine to aspartic acid (G363D) or glycine to arginine (G363R).	Aspartic Acid	129-142	transcription factor IIF subunit TFG1	Saccharomyces cerevisiae S288C	4-9
16147988-3	2005	The ssu71-1 and ssu71-2 alleles were cloned and found to encode single amino acid replacements of glycine-363, either glycine to aspartic acid (G363D) or glycine to arginine (G363R).	Aspartic Acid	129-142	transcription factor IIF subunit TFG1	Saccharomyces cerevisiae S288C	16-21
16098488-0	2005	Preferential differentiation of neural progenitor cells into the glial lineage through gp130 signaling in N-methyl-D-aspartate-treated retinas.	Aspartic Acid	117-126	interleukin 6 signal transducer	Mus musculus	87-92
16164993-3	2005	It has been shown that tRNA(Asp) is able to accept two amino acids: aspartate charged by aspartyl-tRNA synthetase and glutamate charged by YadB.	Aspartic Acid	68-77	hypothetical protein	Escherichia coli	139-143
16164993-7	2005	Among Escherichia coli tRNAs containing queuosine in the wobble position, only tRNA(Asp) is substrate of YadB.	Aspartic Acid	84-87	hypothetical protein	Escherichia coli	105-109
16141513-5	2005	This review introduces our novel "cell delivery system," which employs an Arg-Gly-Asp (RGD) fiber-mutant adenovirus vector encoding the chemokine or chemokine receptor gene in cancer immunotherapy.	Aspartic Acid	82-85	C-X-C motif chemokine receptor 4	Homo sapiens	149-167
16023344-4	2005	The thiobenzylmethylketone warhead on the aspartate was conveniently handled through solid-phase synthesis allowing modification in the P3 region that eventually led to simpler derivatives with increased potency against caspase 3.	Aspartic Acid	42-51	caspase 3	Homo sapiens	220-229
15982908-4	2005	MFG-E8 has two domains: an Arg-Gly-Asp sequence that binds integrins alphavbeta3 and alphavbeta5 (expressed by human DCs and macrophages) and a phosphatidyl-serine (PS) binding sequence through which it associates to PS-containing membranes (among which exosomes).	Aspartic Acid	35-38	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
16153125-7	2005	To encourage cell adhesion, PUs were surface-modified with radio frequency glow discharge followed by coupling of Arg-Gly-Asp-Ser (RGDS).	Aspartic Acid	122-125	ral guanine nucleotide dissociation stimulator	Homo sapiens	131-135
16052557-5	2005	The pK(a) values for the sidechains of Asp-9, Asp-15, and Asp-21 were found to be 3.69, 3.72, and 4.05 respectively.	Aspartic Acid	39-42	beta-secretase 2	Homo sapiens	58-64
15970532-1	2005	In this work, we describe the electrochemical activation of glucose oxidase (GOx) via covalent attachment of a novel redox mediator, Os(bpy)2(API)Cl (bpy = 2,2"-bipyridine, API = 3-aminopropylimidazole), to the peptide backbone of GOx targeting at aspartate and glutamate residues.	Aspartic Acid	248-257	hydroxyacid oxidase 1	Homo sapiens	60-75
15970532-1	2005	In this work, we describe the electrochemical activation of glucose oxidase (GOx) via covalent attachment of a novel redox mediator, Os(bpy)2(API)Cl (bpy = 2,2"-bipyridine, API = 3-aminopropylimidazole), to the peptide backbone of GOx targeting at aspartate and glutamate residues.	Aspartic Acid	248-257	hydroxyacid oxidase 1	Homo sapiens	77-80
16040207-1	2005	Recent reports have indicated that cholesterol-dependent association of tryptophan-aspartate containing coat protein (TACO) plays a crucial role in the entry/survival of Mycobacterium tuberculosis within human macrophages.	Aspartic Acid	83-92	coronin 1A	Homo sapiens	118-122
16140982-2	2005	Here, we identified MITF as a new substrate of caspases and we characterized the cleavage site after Asp 345 in the C-terminal domain.	Aspartic Acid	101-104	melanocyte inducing transcription factor	Homo sapiens	20-24
16052557-5	2005	The pK(a) values for the sidechains of Asp-9, Asp-15, and Asp-21 were found to be 3.69, 3.72, and 4.05 respectively.	Aspartic Acid	46-49	beta-secretase 2	Homo sapiens	58-64
16101838-2	2005	This new DRB1 allele is identical to DRB1*1301 at exon 2 except for a single-nucleotide substitution at codon 37, changing the amino acid Asn to Asp.	Aspartic Acid	145-148	major histocompatibility complex, class II, DR beta 1	Homo sapiens	9-13
16135791-7	2005	Mutation of S368 and S372 to a phosphomimic aspartate residue decreases the association of GGA3 with membranes.	Aspartic Acid	44-53	golgi associated, gamma adaptin ear containing, ARF binding protein 3	Homo sapiens	91-95
16101838-2	2005	This new DRB1 allele is identical to DRB1*1301 at exon 2 except for a single-nucleotide substitution at codon 37, changing the amino acid Asn to Asp.	Aspartic Acid	145-148	major histocompatibility complex, class II, DR beta 1	Homo sapiens	37-41
16101301-2	2005	Zinc-free insulin, which is primarily dimeric at room temperature, unfolded at approximately 70 degrees C. The two monomeric insulin mutants Asp(B28) and Asp(B9),Glu(B27) unfolded at higher temperatures, but with enthalpies of unfolding that were approximately 30% smaller.	Aspartic Acid	141-144	insulin	Homo sapiens	10-17
16055093-0	2005	Thyrotropin-releasing hormone (protirelin) inhibits potassium-stimulated glutamate and aspartate release from hippocampal slices in vitro.	Aspartic Acid	87-96	thyrotropin releasing hormone	Rattus norvegicus	0-29
16055093-3	2005	Using superfused hippocampal slices, we tested the hypothesis that TRH could inhibit evoked glutamate/aspartate release in vitro.	Aspartic Acid	102-111	thyrotropin releasing hormone	Rattus norvegicus	67-70
16101301-2	2005	Zinc-free insulin, which is primarily dimeric at room temperature, unfolded at approximately 70 degrees C. The two monomeric insulin mutants Asp(B28) and Asp(B9),Glu(B27) unfolded at higher temperatures, but with enthalpies of unfolding that were approximately 30% smaller.	Aspartic Acid	141-144	insulin	Homo sapiens	125-132
16055093-6	2005	TRH had no effect on baseline glutamate/aspartate release, while all three TRH doses significantly (P &lt; 0.05) inhibited peak 50 mM [K(+)]-stimulated glutamate/aspartate release, and glutamate remained below control (P &lt; 0.05) at 15 min post stimulation.	Aspartic Acid	162-171	thyrotropin releasing hormone	Rattus norvegicus	75-78
16055093-8	2005	These results are the first to show a potent and prolonged inhibitory effect of TRH on evoked glutamate/aspartate release in vitro.	Aspartic Acid	104-113	thyrotropin releasing hormone	Rattus norvegicus	80-83
15970597-12	2005	The results demonstrate that in human cationic trypsinogen the Asp(19-22) motif per se is not required for enteropeptidase recognition, whereas it is essential for maximal suppression of autoactivation.	Aspartic Acid	63-66	serine protease 1	Homo sapiens	38-58
15975930-11	2005	These data demonstrated that the proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for recognition and cleavage of von Willebrand factor between amino acid residues Asp(1595) and Arg(1668).	Aspartic Acid	215-218	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	71-79
15975930-11	2005	These data demonstrated that the proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for recognition and cleavage of von Willebrand factor between amino acid residues Asp(1595) and Arg(1668).	Aspartic Acid	215-218	von Willebrand factor	Homo sapiens	165-186
16042579-7	2005	Moreover, studies on clusters of sequence-variant repeats, which are interspersed in the repeat domain of MUC1 at high frequency, have revealed that a limited set of concerted amino-acid replacements (Asp-Thr0-Arg1-Pro10 to Glu-Ser0-Arg1-Ala10) contributes considerably to increased peptide flexibility and to under-glycosylation of sequence-variant repeats which in concert modify immunological features of the mucin.	Aspartic Acid	201-204	mucin 1, cell surface associated	Homo sapiens	106-110
16060660-3	2005	P14 was designed with a 15-base sequence complementary to the antisense strand of KRAS at the GAT (Asp) mutation and conjugated to the nuclear localization signal peptide PKKKRKV.	Aspartic Acid	99-102	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-3
16060660-3	2005	P14 was designed with a 15-base sequence complementary to the antisense strand of KRAS at the GAT (Asp) mutation and conjugated to the nuclear localization signal peptide PKKKRKV.	Aspartic Acid	99-102	KRAS proto-oncogene, GTPase	Homo sapiens	82-86
16042383-2	2005	There are 11 charged residues in the 82-116 loop of human fXa (Glu-84, Glu-86, Lys-90, Arg-93, Lys-96, Glu-97, Asp-100, Asp-102, Arg-107, Lys-109, and Arg-115).	Aspartic Acid	111-114	coagulation factor X	Homo sapiens	58-61
16042383-2	2005	There are 11 charged residues in the 82-116 loop of human fXa (Glu-84, Glu-86, Lys-90, Arg-93, Lys-96, Glu-97, Asp-100, Asp-102, Arg-107, Lys-109, and Arg-115).	Aspartic Acid	120-123	coagulation factor X	Homo sapiens	58-61
16048935-4	2005	One group of amino acid changes in ScFks1p, ScFks2p, and CaFks1p defines a conserved region (Phe 641 to Asp 648 of CaFks1p) in the Fks1 family of proteins.	Aspartic Acid	104-107	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	37-41
15998637-1	2005	Previous studies have suggested that thrombin interacts with integrins in endothelial cells through its RGD (Arg-187, Gly-188, Asp-189) sequence.	Aspartic Acid	127-130	coagulation factor II, thrombin	Homo sapiens	37-45
16024041-2	2005	BHK cells infected with viral particles carrying the GLT-1 gene exhibited 30-fold increased aspartate uptake compared to control cells.	Aspartic Acid	92-101	solute carrier family 1 member 2	Rattus norvegicus	53-58
16060660-1	2005	Mutations in the Kirsten ras (KRAS) gene are present in almost all pancreatic adenocarcinomas, and one common mutation is at codon 12: GGT (Gly) is transformed into GAT (Asp).	Aspartic Acid	170-173	KRAS proto-oncogene, GTPase	Homo sapiens	17-28
16060660-1	2005	Mutations in the Kirsten ras (KRAS) gene are present in almost all pancreatic adenocarcinomas, and one common mutation is at codon 12: GGT (Gly) is transformed into GAT (Asp).	Aspartic Acid	170-173	KRAS proto-oncogene, GTPase	Homo sapiens	30-34
16060660-1	2005	Mutations in the Kirsten ras (KRAS) gene are present in almost all pancreatic adenocarcinomas, and one common mutation is at codon 12: GGT (Gly) is transformed into GAT (Asp).	Aspartic Acid	170-173	glycine-N-acyltransferase	Homo sapiens	165-168
16042579-7	2005	Moreover, studies on clusters of sequence-variant repeats, which are interspersed in the repeat domain of MUC1 at high frequency, have revealed that a limited set of concerted amino-acid replacements (Asp-Thr0-Arg1-Pro10 to Glu-Ser0-Arg1-Ala10) contributes considerably to increased peptide flexibility and to under-glycosylation of sequence-variant repeats which in concert modify immunological features of the mucin.	Aspartic Acid	201-204	arginase 1	Homo sapiens	210-214
16081940-0	2005	Comparative sequencing of the serine-aspartate repeat-encoding region of the clumping factor B gene (clfB) for resolution within clonal groups of Staphylococcus aureus.	Aspartic Acid	37-46	AT695_RS04065	Staphylococcus aureus	77-94
16100771-4	2005	RESULTS: Sequence analysis identified the existence of many polymorphisms; in codon 24 of exon 1, GGC (Gly) into GAC (Asp); in codon 30 of exon 1, CGG (Arg) into CGC (Arg); in exon 3 codon 169, ACA to ACG (both encoding for threonine); in exon 5, AGA to AGG (both encoding for arginine, codon 260); and T/C polymorphism in intron 2.	Aspartic Acid	118-121	gamma-glutamylcyclotransferase	Homo sapiens	98-101
16038904-4	2005	In addition, recombinant caspase-3 and 8 cleaved p23 at Asp 142 generating a degradation product of 18 kDa as seen in apoptotic cells.	Aspartic Acid	56-59	caspase 3	Homo sapiens	25-34
16038904-4	2005	In addition, recombinant caspase-3 and 8 cleaved p23 at Asp 142 generating a degradation product of 18 kDa as seen in apoptotic cells.	Aspartic Acid	56-59	prostaglandin E synthase 3	Homo sapiens	49-52
15722127-1	2005	A non-peptide mimic of the Arg-Gly Asp (RGD) active sequence of adhesive proteins (such as vitronectin) has been equipped with two different spacer-arms for surface anchorage.	Aspartic Acid	35-38	vitronectin	Homo sapiens	91-102
15879005-0	2005	Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.	Aspartic Acid	201-214	solute carrier family 6 member 3	Homo sapiens	56-59
15930519-7	2005	Site-directed mutagenesis was used to support proposals for the identity of the iron binding ligands (His-175, Asp-177, His-264) of the 2-His-1-carboxylate motif of PAHX.	Aspartic Acid	111-114	phytanoyl-CoA 2-hydroxylase	Homo sapiens	165-169
15879005-2	2005	A longstanding postulate holds that cocaine inhibits DAT-mediated dopamine transport via competition with dopamine for formation of an ionic bond with the DAT transmembrane aspartic acid residue D79.	Aspartic Acid	173-186	solute carrier family 6 member 3	Homo sapiens	53-56
15879005-2	2005	A longstanding postulate holds that cocaine inhibits DAT-mediated dopamine transport via competition with dopamine for formation of an ionic bond with the DAT transmembrane aspartic acid residue D79.	Aspartic Acid	173-186	solute carrier family 6 member 3	Homo sapiens	155-158
15964018-3	2005	Whereas gp120 subunits with Asp or Asn at position 324 were fusogenic with coreceptor chimeras containing either the N-terminal domain or the body of CCR5, substitution of charged (Glu, Lys) or small hydrophobic (Gly, Ala) residues resulted in complete loss of fusogenic activity with the N terminus and markedly reduced utilization of the body of CCR5, although their ability to use wild-type CCR5 was unchanged.	Aspartic Acid	28-31	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	8-13
16041368-7	2005	Mutation of a potential proline-dependent kinase phosphorylation site at residue 95, from threonine to aspartic acid (T95D) within the NES motif, abolishes NPM association and inhibition of centrosome duplication.	Aspartic Acid	103-116	nucleophosmin 1	Homo sapiens	156-159
16061593-4	2005	L-aspartic acid and EHC inhibit beta-glucuronidase.	Aspartic Acid	0-15	glucuronidase beta	Homo sapiens	32-50
16014962-4	2005	By changing phosphorylated amino acids to alanines and aspartates, we have mapped the phosphorylated sites of NS2 to two serine residues at positions 249 and 259.	Aspartic Acid	55-65	NS2	Homo sapiens	110-113
15964018-6	2005	Infection of primary CD4(+)T cells demonstrated that Env bearing Asp324 was less sensitive to RANTES, suggesting that Asp or Asn in this position may be crucial for viral fitness.	Aspartic Acid	65-68	CD4 molecule	Homo sapiens	21-24
15964018-6	2005	Infection of primary CD4(+)T cells demonstrated that Env bearing Asp324 was less sensitive to RANTES, suggesting that Asp or Asn in this position may be crucial for viral fitness.	Aspartic Acid	65-68	endogenous retrovirus group K member 20	Homo sapiens	53-56
15964018-6	2005	Infection of primary CD4(+)T cells demonstrated that Env bearing Asp324 was less sensitive to RANTES, suggesting that Asp or Asn in this position may be crucial for viral fitness.	Aspartic Acid	65-68	C-C motif chemokine ligand 5	Homo sapiens	94-100
15908425-0	2005	Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B.	Aspartic Acid	74-83	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	0-39
15964018-9	2005	These findings indicate that Asp or Asn at position 324 of the V3 stem stabilizes the conformation of V3 loop and hence influences the intensities of interaction between CD4-activated gp120 and CCR5 which results in viral entry.	Aspartic Acid	29-32	CD4 molecule	Homo sapiens	170-173
15964018-9	2005	These findings indicate that Asp or Asn at position 324 of the V3 stem stabilizes the conformation of V3 loop and hence influences the intensities of interaction between CD4-activated gp120 and CCR5 which results in viral entry.	Aspartic Acid	29-32	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	184-189
15964018-9	2005	These findings indicate that Asp or Asn at position 324 of the V3 stem stabilizes the conformation of V3 loop and hence influences the intensities of interaction between CD4-activated gp120 and CCR5 which results in viral entry.	Aspartic Acid	29-32	C-C motif chemokine receptor 5	Homo sapiens	194-198
16002466-3	2005	To date, all of the characterized forms of ATE1 in yeast and mammals have been shown to arginylate only Asp and Glu, leaving open to speculation whether Cys arginylation is possible only through other components of mammalian arginylation machinery and whether Cys-specific forms of Arg-transferase exist in mammals.	Aspartic Acid	104-107	arginyltransferase 1	Homo sapiens	43-47
16002466-5	2005	We also show that the two previously identified mammalian forms of ATE1 can arginylate Cys-containing substrates in addition to Asp- and Glu-containing substrates.	Aspartic Acid	128-131	arginyltransferase 1	Homo sapiens	67-71
15908694-4	2005	Using both disruptive as well as reciprocal mutagenesis strategies, our studies demonstrate that the ability of L457R to stabilize an active form of the hLHR is because of the formation of a salt bridge between the replacing amino acid and Asp-578 in helix 6.	Aspartic Acid	240-243	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	153-157
15741239-7	2005	On the other hand, insulin stimulated leptin secretion when glucose was replaced by L-aspartate, L-valine, L-methionine, or L-phenylalanine, but not by L-leucine (all 5 mM).	Aspartic Acid	84-95	insulin	Homo sapiens	19-26
15894802-2	2005	A short region of the mGluR5 C terminus is the critical determinant and differs from the analogous region of mGluR1alpha by a single amino acid residue, Thr-840, which is an aspartic acid (Asp-854) in mGluR1alpha.	Aspartic Acid	174-187	glutamate receptor, ionotropic, kainate 1	Mus musculus	22-28
15894802-2	2005	A short region of the mGluR5 C terminus is the critical determinant and differs from the analogous region of mGluR1alpha by a single amino acid residue, Thr-840, which is an aspartic acid (Asp-854) in mGluR1alpha.	Aspartic Acid	189-192	glutamate receptor, ionotropic, kainate 1	Mus musculus	22-28
16032772-0	2005	Specific aspartate residues in FET3 control high-affinity iron transport in Saccharomyces cerevisiae.	Aspartic Acid	9-18	ferroxidase FET3	Saccharomyces cerevisiae S288C	31-35
16032772-1	2005	Site-directed mutagenesis was performed on a set of six aspartate residues of Fet3, the multicopper ferroxidase involved in high-affinity iron transport in Saccharomyces cerevisiae, in order to comprehend the molecular determinants of the protein function.	Aspartic Acid	56-65	ferroxidase FET3	Saccharomyces cerevisiae S288C	78-82
16032772-1	2005	Site-directed mutagenesis was performed on a set of six aspartate residues of Fet3, the multicopper ferroxidase involved in high-affinity iron transport in Saccharomyces cerevisiae, in order to comprehend the molecular determinants of the protein function.	Aspartic Acid	56-65	ferroxidase	Saccharomyces cerevisiae S288C	100-111
16032772-9	2005	In turn, this might be evidence of a shielding role of the permease Ftr1, which could interact with Fet3 at the level of the aspartate-rich negatively charged region.	Aspartic Acid	125-134	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	68-72
16032772-9	2005	In turn, this might be evidence of a shielding role of the permease Ftr1, which could interact with Fet3 at the level of the aspartate-rich negatively charged region.	Aspartic Acid	125-134	ferroxidase FET3	Saccharomyces cerevisiae S288C	100-104
15741239-7	2005	On the other hand, insulin stimulated leptin secretion when glucose was replaced by L-aspartate, L-valine, L-methionine, or L-phenylalanine, but not by L-leucine (all 5 mM).	Aspartic Acid	84-95	leptin	Homo sapiens	38-44
15942648-2	2005	We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains.	Aspartic Acid	168-171	ubiquitin specific peptidase 7	Mus musculus	45-50
15965534-3	2005	Previous studies of the chimeric proteins, which incorporate the ligand-binding domain of the human ER, identified Cys 381, Cys 447, Glu 523, His 524 and Asp 538 as possible sites of interactions with cadmium.	Aspartic Acid	154-157	estrogen receptor 1	Homo sapiens	100-102
15966899-5	2005	Rbx1 is a highly evolutionarily conserved protein; however, the eighth coordination residue in its RING finger is aspartate (D97) rather than cysteine.	Aspartic Acid	114-123	ring-box 1	Homo sapiens	0-4
15942648-2	2005	We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains.	Aspartic Acid	168-171	ubiquitin specific peptidase 7	Mus musculus	52-58
15942648-2	2005	We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains.	Aspartic Acid	190-193	ubiquitin specific peptidase 7	Mus musculus	45-50
15942648-2	2005	We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains.	Aspartic Acid	190-193	ubiquitin specific peptidase 7	Mus musculus	52-58
15942654-5	2005	The caspase cleavage-resistant mutant PKCdelta (DMQA) was generated by mutating the aspartate residue at the site of proteolysis DMQD downward arrowN to alanine (D330A), and the wild-type and mutant PKCdelta were introduced into H69 cells.	Aspartic Acid	84-93	protein kinase C delta	Homo sapiens	38-46
15886202-3	2005	Mutation of the PAK and Src phosphorylation sites on Raf-1 to aspartate, a phosphate mimic, prevented RKIP association with or inhibition of Raf-1 signaling.	Aspartic Acid	62-71	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-27
15878871-12	2005	Single mutations at amino acid positions Lys(114), Asp(169), Thr(173), Tyr(175), and Leu(176) affected C1q binding to CRP.	Aspartic Acid	51-54	complement C1q A chain	Homo sapiens	103-106
15878871-12	2005	Single mutations at amino acid positions Lys(114), Asp(169), Thr(173), Tyr(175), and Leu(176) affected C1q binding to CRP.	Aspartic Acid	51-54	C-reactive protein	Homo sapiens	118-121
15870068-5	2005	By incorporating mutations into these amino acids, we identified Tyr-207, Asp-271, Tyr-315, and Asp-318 in the CRH of human IL-13Ralpha2, and Leu-319 and Tyr-321 in the CRH of human IL-13Ralpha1, as critical residues for binding to IL-13.	Aspartic Acid	74-77	corticotropin releasing hormone	Homo sapiens	111-114
15870068-5	2005	By incorporating mutations into these amino acids, we identified Tyr-207, Asp-271, Tyr-315, and Asp-318 in the CRH of human IL-13Ralpha2, and Leu-319 and Tyr-321 in the CRH of human IL-13Ralpha1, as critical residues for binding to IL-13.	Aspartic Acid	74-77	interleukin 13 receptor subunit alpha 2	Homo sapiens	124-136
15870068-5	2005	By incorporating mutations into these amino acids, we identified Tyr-207, Asp-271, Tyr-315, and Asp-318 in the CRH of human IL-13Ralpha2, and Leu-319 and Tyr-321 in the CRH of human IL-13Ralpha1, as critical residues for binding to IL-13.	Aspartic Acid	74-77	interleukin 13	Homo sapiens	124-129
15870068-5	2005	By incorporating mutations into these amino acids, we identified Tyr-207, Asp-271, Tyr-315, and Asp-318 in the CRH of human IL-13Ralpha2, and Leu-319 and Tyr-321 in the CRH of human IL-13Ralpha1, as critical residues for binding to IL-13.	Aspartic Acid	96-99	corticotropin releasing hormone	Homo sapiens	111-114
15870068-5	2005	By incorporating mutations into these amino acids, we identified Tyr-207, Asp-271, Tyr-315, and Asp-318 in the CRH of human IL-13Ralpha2, and Leu-319 and Tyr-321 in the CRH of human IL-13Ralpha1, as critical residues for binding to IL-13.	Aspartic Acid	96-99	interleukin 13 receptor subunit alpha 2	Homo sapiens	124-136
15870068-5	2005	By incorporating mutations into these amino acids, we identified Tyr-207, Asp-271, Tyr-315, and Asp-318 in the CRH of human IL-13Ralpha2, and Leu-319 and Tyr-321 in the CRH of human IL-13Ralpha1, as critical residues for binding to IL-13.	Aspartic Acid	96-99	interleukin 13	Homo sapiens	124-129
15886202-3	2005	Mutation of the PAK and Src phosphorylation sites on Raf-1 to aspartate, a phosphate mimic, prevented RKIP association with or inhibition of Raf-1 signaling.	Aspartic Acid	62-71	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	53-58
15886202-3	2005	Mutation of the PAK and Src phosphorylation sites on Raf-1 to aspartate, a phosphate mimic, prevented RKIP association with or inhibition of Raf-1 signaling.	Aspartic Acid	62-71	phosphatidylethanolamine binding protein 1	Homo sapiens	102-106
15886202-3	2005	Mutation of the PAK and Src phosphorylation sites on Raf-1 to aspartate, a phosphate mimic, prevented RKIP association with or inhibition of Raf-1 signaling.	Aspartic Acid	62-71	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	141-146
15641124-4	2005	During the synthesis of sPB1-F2, the formation of succinimide and subsequent conversion to the piperidine derivative at the aspartic acid residue in position 23 was observed.	Aspartic Acid	124-137	FtsJ RNA 2'-O-methyltransferase 3	Homo sapiens	24-28
15998291-3	2005	The vast majority of the cells were found to take up aspartate, mainly through the glutamate/aspartate transporter (GLAST), and at least 60% expressed functional mGluR5a.	Aspartic Acid	53-62	solute carrier family 1 member 3	Rattus norvegicus	83-114
15998291-3	2005	The vast majority of the cells were found to take up aspartate, mainly through the glutamate/aspartate transporter (GLAST), and at least 60% expressed functional mGluR5a.	Aspartic Acid	53-62	solute carrier family 1 member 3	Rattus norvegicus	116-121
15998291-7	2005	The acute influence of mGluR5 on aspartate uptake was phospholipase C- and protein kinase C-dependent, and was mimicked by phorbol esters.	Aspartic Acid	33-42	glutamate receptor, ionotropic, kainate 1	Mus musculus	23-29
15920735-2	2005	OPN contains the arginine-glycine-aspartic acid (RGD) moiety that has been shown to mediate cell adhesion through interactions with integrins.	Aspartic Acid	34-47	secreted phosphoprotein 1	Bos taurus	0-3
15953349-4	2005	Stabilization of the resultant N- and C-terminal fragments, which carry the catalytically active site aspartates, but not endoproteolysis itself, requires the C-terminal domain of PEN-2.	Aspartic Acid	102-112	presenilin enhancer, gamma-secretase subunit	Homo sapiens	180-185
15980455-1	2005	Caspases and granzyme B are proteases that share the primary specificity to cleave at the carboxyl terminal of aspartate residues in their substrates.	Aspartic Acid	111-120	caspase 1	Homo sapiens	0-8
15748781-5	2005	Immunohistochemical studies indicate that cleavage at aspartic acid(421) occurs after formation of the Alz50 epitope but prior to formation of the Tau-66 epitope and truncation at glutamic acid(391) (formation of the MN423 epitope).	Aspartic Acid	54-67	microtubule associated protein tau	Homo sapiens	147-150
15888376-4	2005	As a result, oxaloacetate is consumed and is less available to the aspartate aminotransferase reaction; therefore, less glutamate is converted to aspartate and relatively more glutamate becomes available to the glutamine synthetase and glutamate decarboxylase reactions.	Aspartic Acid	67-76	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	211-231
15980455-1	2005	Caspases and granzyme B are proteases that share the primary specificity to cleave at the carboxyl terminal of aspartate residues in their substrates.	Aspartic Acid	111-120	granzyme B	Homo sapiens	13-23
15888376-4	2005	As a result, oxaloacetate is consumed and is less available to the aspartate aminotransferase reaction; therefore, less glutamate is converted to aspartate and relatively more glutamate becomes available to the glutamine synthetase and glutamate decarboxylase reactions.	Aspartic Acid	67-76	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	236-259
16008726-5	2005	Furthermore, serum deprivation-induced apoptosis in a keloid fibroblast line was blocked by a caspase-9 inhibitor (acetyl-Leu-Glu-His-Asp-al), indicating that activation of caspase-9 was necessary for the process of apoptosis in keloid fibroblasts.	Aspartic Acid	134-137	caspase 9	Homo sapiens	94-103
16008726-5	2005	Furthermore, serum deprivation-induced apoptosis in a keloid fibroblast line was blocked by a caspase-9 inhibitor (acetyl-Leu-Glu-His-Asp-al), indicating that activation of caspase-9 was necessary for the process of apoptosis in keloid fibroblasts.	Aspartic Acid	134-137	caspase 9	Homo sapiens	173-182
15969502-2	2005	The copresence of the two known genetic variants A (Asp(244)) and B (Gly(244)) was ascertained in bovine chymosin.	Aspartic Acid	52-55	chymosin	Bos taurus	105-113
15950597-4	2005	An amino acid substitution in Nha1p (D266N, Asp-266 to Asn) almost completely abolished the Na+/H+ but not K+/H+ antiport activity, confirming the validity of this assay system as well as the functional importance of Asp-266, especially for selectivity of substrate cations.	Aspartic Acid	44-47	Nha1p	Saccharomyces cerevisiae S288C	30-35
15894113-2	2005	Serial deletion studies showed that at least three amino acid residues, alanine-alanine-aspartic acid (A-A-D), preceding the first cysteine at the NH(2)-terminus are essential for the biological activity of Lkn-1.	Aspartic Acid	88-101	C-C motif chemokine ligand 15	Homo sapiens	207-212
15826943-8	2005	To define the epitope residues for AF17121, we defined its binding footprint on IL5Ralpha by alanine substitution of Asp(55), Asp(56), Glu(58), Lys(186), Arg(188), and Arg(297) of the receptor.	Aspartic Acid	117-120	interleukin 5 receptor subunit alpha	Homo sapiens	80-89
15826943-9	2005	Marked effects on the interaction were observed in all three fibronectin type III domains of IL5Ralpha, in particular Asp(55), Arg(188), and Arg(297) in the D1, D2, and D3 domains, respectively.	Aspartic Acid	118-121	interleukin 5 receptor subunit alpha	Homo sapiens	93-102
15845551-7	2005	Neutralization of Asp(984) resulted in a non-functional channel with a dominant negative phenotype when coexpressed with wild type TRPM4.	Aspartic Acid	18-21	transient receptor potential cation channel subfamily M member 4	Homo sapiens	131-136
15894113-8	2005	These results identify that alanine-aspartic acid residues preceding the first cysteine at the NH(2)-terminus are essential for the binding and biological activity of Lkn-1.	Aspartic Acid	36-49	C-C motif chemokine ligand 15	Homo sapiens	167-172
15938616-7	2005	The beta-strand B of Ca.CD2 that provides two Asp for the Ca(2+) undergoes an S(2) decrease upon the Ca(2+) binding, while the DE-loop that provides one Asn and one Asp undergoes an S(2) increase.	Aspartic Acid	46-49	Cd2 molecule	Rattus norvegicus	21-27
15817634-5	2005	Critical glutamate, aspartate, lysine, arginine and histidine residues in ILs/ELs and TMs were detected that were essential for kNBC1-mediated Na(+)-dependent base transport.	Aspartic Acid	20-29	solute carrier family 4 member 4	Homo sapiens	128-133
15928046-10	2005	When NaCl was replaced with sodium aspartate, transepithelial electrical resistance was significantly decreased and dilution potentials were increased in claudin-7-overexpressing cells as compared to controls, the opposite effects from that of using NaCl.	Aspartic Acid	28-44	claudin 7	Sus scrofa	154-163
15938616-7	2005	The beta-strand B of Ca.CD2 that provides two Asp for the Ca(2+) undergoes an S(2) decrease upon the Ca(2+) binding, while the DE-loop that provides one Asn and one Asp undergoes an S(2) increase.	Aspartic Acid	165-168	Cd2 molecule	Rattus norvegicus	21-27
15603814-1	2005	Chitosan scaffolds were modified with RGDS (Arg-Gly-Asp-Ser) in the present work via an imide-bond forming reaction between amino groups in chitosan and carboxyl groups in peptides.	Aspartic Acid	52-55	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	38-42
15797863-10	2005	Taken together, results have shown that NTF and CTF integrate differently into high molecular weight aggregates and that PS-1 Asp-257 and Asp-385 have different accessibilities in their unendoproteolyzed conformation.	Aspartic Acid	126-129	presenilin 1	Homo sapiens	121-125
15924414-9	2005	The observations suggest a model in which the known ion pair between lysine in TMD II and aspartate in TMD XI controls the conformation or relative position of TMD XI, which in turn controls additional TMDs in the C-terminal half of VAChT.	Aspartic Acid	90-99	solute carrier family 18 member A3	Rattus norvegicus	233-238
15924420-1	2005	Each homologous lobe of human serum transferrin (hTF) has one Fe(3+) ion bound by an aspartic acid, a histidine, two tyrosine residues, and two oxygens from the synergistic anion, carbonate.	Aspartic Acid	85-98	transferrin	Homo sapiens	36-47
15938724-1	2005	We describe haematological and DNA characterization of haemoglobinopathies in Thai adolescents caused by compound heterozygosities for Hb E [beta26(B8) Glu-Lys] and two other beta-globin chain variants, Hb Pyrgos [beta83(EF7) Gly-Asp] and Hb J Bangkok [beta56(D7) Gly-Asp].	Aspartic Acid	230-233	hemoglobin subunit epsilon 1	Homo sapiens	135-139
15821163-6	2005	For thioredoxin Asp-26, which has a large pK(a) upshift, we correctly capture the balance between unfavorable carboxylate desolvation and favorable interactions with a nearby lysine; similarly for RNase A Asp-14, which has a large pK(a) downshift.	Aspartic Acid	16-19	thioredoxin	Homo sapiens	4-15
15821163-6	2005	For thioredoxin Asp-26, which has a large pK(a) upshift, we correctly capture the balance between unfavorable carboxylate desolvation and favorable interactions with a nearby lysine; similarly for RNase A Asp-14, which has a large pK(a) downshift.	Aspartic Acid	205-208	thioredoxin	Homo sapiens	4-15
15821163-7	2005	For the unshifted thioredoxin Asp-20, desolvation by the protein cavity is overestimated by 2.9 pK(a) units; several effects could explain this.	Aspartic Acid	30-33	thioredoxin	Homo sapiens	18-29
15938724-1	2005	We describe haematological and DNA characterization of haemoglobinopathies in Thai adolescents caused by compound heterozygosities for Hb E [beta26(B8) Glu-Lys] and two other beta-globin chain variants, Hb Pyrgos [beta83(EF7) Gly-Asp] and Hb J Bangkok [beta56(D7) Gly-Asp].	Aspartic Acid	268-271	hemoglobin subunit epsilon 1	Homo sapiens	135-139
15901998-2	2005	A genetic polymorphism of the GSTO1 gene causing an alanine-to-aspartate (A140D) substitution in amino acid 140 produces a variant with lowered enzyme activities in the biotransformation of inorganic arsenic, a common contaminant of drinking water in many regions of the world and a well-known carcinogen.	Aspartic Acid	63-72	glutathione S-transferase omega 1	Homo sapiens	30-35
16147881-3	2005	The new allele was similar to HLA-DPB1*1601, however, it varied in two single nucleotide polymorphisms resulting in alanine residues at positions 55 and 56 of the mature protein rather than aspartic acid and glutamic acid, respectively.	Aspartic Acid	190-203	major histocompatibility complex, class II, DP beta 1	Homo sapiens	30-38
15955065-0	2005	Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2.	Aspartic Acid	152-166	solute carrier family 20 member 2	Homo sapiens	235-239
15955065-5	2005	We changed either of the highly conserved aspartates, Asp28 and Asp506, in the N- and C-terminal signature sequences, respectively, of human PiT2 to asparagine and analyzed P(i) uptake function in Xenopus laevis oocytes.	Aspartic Acid	42-52	solute carrier family 20 member 2	Homo sapiens	141-145
15955065-9	2005	Thus the presence of an aspartic acid in either of the PiT family signature sequences is critical for the Na+-dependent P(i) transport function of human PiT2.	Aspartic Acid	24-37	solute carrier family 20 member 2	Homo sapiens	153-157
15955067-5	2005	In Rv0386, the standard substrate, adenine-defining lysine-aspartate couple is replaced by glutamine-asparagine.	Aspartic Acid	59-68	transcriptional regulator	Mycobacterium tuberculosis H37Rv	3-9
16002990-6	2005	In this study, we observed that Ku80 is cleaved at Asp-730 residue during apoptosis, and this cleavage occurs in the nucleus in the early apoptotic phase.	Aspartic Acid	51-54	X-ray repair cross complementing 5	Homo sapiens	32-36
15887042-4	2005	On incubation with SS-Co(III)X and S-Co(III)Y, both Ang-I and Ang-II were cleaved by oxidative decarboxylation instead of peptide hydrolysis: the N-terminal Asp residues of Ang-I and Ang-II were converted to pyruvate residues.	Aspartic Acid	157-160	angiotensinogen	Homo sapiens	62-68
15955463-2	2005	The purpose of the present study was to investigate whether a high cholesterol diet supplemented with aspartate and glutamate may alter lipoproteins cholesterol and apolipoproteins A-1 and B levels in rabbits.	Aspartic Acid	102-111	apolipoprotein A-I	Oryctolagus cuniculus	165-190
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	coagulation factor II thrombin receptor	Homo sapiens	49-53
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	C-C motif chemokine ligand 2	Homo sapiens	110-144
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	C-C motif chemokine ligand 2	Homo sapiens	146-151
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	158-174
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	176-181
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	C-C motif chemokine ligand 2	Homo sapiens	220-225
15956340-6	2005	Other perturbations, such as those of Gly 19 and Asp 20 of IGF-I (and the corresponding residues in IGF-II) - which are located in a reverse turn linking N-domain and C-domain interactive surfaces - are due to local conformational changes in the IGF-I and -II.	Aspartic Acid	49-52	insulin like growth factor 2	Bos taurus	59-64
15788415-0	2005	Probing the role of Asp-120(81) of metallo-beta-lactamase (IMP-1) by site-directed mutagenesis, kinetic studies, and X-ray crystallography.	Aspartic Acid	20-23	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	59-64
15788399-9	2005	Moreover, Asn to Asp mutations at either of two of the N-glycosylation sites of ZPB, residue 203 or 220, significantly reduced the sperm binding activity of the ZPB/ZPC mixture, whereas a similar mutation at the third N-glycosylation site, Asn-333, had no effect on binding.	Aspartic Acid	17-20	zona pellucida glycoprotein 4	Homo sapiens	80-83
15943912-0	2005	Study of alanine-73 and aspartate-9 of HLA-C locus in Saudi psoriasis patients, using sequence-specific primers (PCR-SSP).	Aspartic Acid	24-33	major histocompatibility complex, class I, C	Homo sapiens	39-44
15943912-1	2005	Alanine at residue 73 (Ala-73) and aspartate at residue 9 (Asp-9) are characteristic to both Cw6 and Cw7 alleles of HLA-C gene and have been suggested as possible markers for psoriasis vulgaris (PsV).	Aspartic Acid	35-44	major histocompatibility complex, class I, C	Homo sapiens	116-121
15943912-1	2005	Alanine at residue 73 (Ala-73) and aspartate at residue 9 (Asp-9) are characteristic to both Cw6 and Cw7 alleles of HLA-C gene and have been suggested as possible markers for psoriasis vulgaris (PsV).	Aspartic Acid	59-62	major histocompatibility complex, class I, C	Homo sapiens	116-121
15943912-3	2005	In this study, an attempt has been made to examine the association between HLA-C (Ala-73 and Asp-9) and susceptibility to PsV among Saudi patients.	Aspartic Acid	93-96	major histocompatibility complex, class I, C	Homo sapiens	75-80
15788399-9	2005	Moreover, Asn to Asp mutations at either of two of the N-glycosylation sites of ZPB, residue 203 or 220, significantly reduced the sperm binding activity of the ZPB/ZPC mixture, whereas a similar mutation at the third N-glycosylation site, Asn-333, had no effect on binding.	Aspartic Acid	17-20	zona pellucida glycoprotein 4	Homo sapiens	161-164
15788415-2	2005	Wild-type (WT) IMP-1 has a conserved Asp-120(81) in the active site, which plays an important role in catalysis.	Aspartic Acid	37-40	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	15-20
15788415-8	2005	These results suggest that Asp-120(81) of IMP-1 is not a factor in decreasing the pK(a) for the water bridging two Zn(II) ions and is not a proton donor to the anionic intermediate.	Aspartic Acid	27-30	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	42-47
15774476-3	2005	Recent reports have demonstrated that shortly after the initiation of apoptosis in S2 cells, DIAP1 is cleaved following aspartate residue Asp-20 by the effector caspase DrICE.	Aspartic Acid	120-129	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	93-98
15878328-6	2005	These results, together, indicate that QBRICK is an adhesive ligand of basement membrane distinctively recognized by cells in the embryonic skin and hair follicles through different types of integrins directed to the Arg-Gly-Asp motif.	Aspartic Acid	225-228	Fras1 related extracellular matrix protein 1	Mus musculus	39-45
15894612-7	2005	Formation of a three-helix interface among the TM domains involved ionizable residues from all three chains, the TM arginine of NKG2D and both TM aspartic acids of the DAP10 dimer.	Aspartic Acid	146-160	hematopoietic cell signal transducer	Homo sapiens	168-173
15631619-3	2005	The STNB protein contains a domain that has homology with the mu-subunit of the AP (adaptor protein) complex, as well as a number of NPF (Asp-Pro-Phe) motifs known to bind EH (Eps15 homology) domains.	Aspartic Acid	138-141	stoned B	Drosophila melanogaster	4-8
15757904-12	2005	This novel examination of substrate-transporter kinetics indicates that a single ASP+ molecule binds and unbinds thousands of times before being transported or ultimately dissociated from hNET.	Aspartic Acid	81-85	solute carrier family 6 member 2	Homo sapiens	188-192
15774476-3	2005	Recent reports have demonstrated that shortly after the initiation of apoptosis in S2 cells, DIAP1 is cleaved following aspartate residue Asp-20 by the effector caspase DrICE.	Aspartic Acid	138-141	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	93-98
15865443-2	2005	Previous studies have shown that p42(mapk/erk2) phosphorylates Ser and Thr residues (T236, S240, S244, and S270) in the membrane proximal region of TNF-R1 and that mutation of these residues to Glu and Asp residues (TNF-R1.4D/E) mimics the effect of phosphorylation on receptor signaling and localization.	Aspartic Acid	202-205	cyclin dependent kinase 20	Homo sapiens	33-36
15865443-2	2005	Previous studies have shown that p42(mapk/erk2) phosphorylates Ser and Thr residues (T236, S240, S244, and S270) in the membrane proximal region of TNF-R1 and that mutation of these residues to Glu and Asp residues (TNF-R1.4D/E) mimics the effect of phosphorylation on receptor signaling and localization.	Aspartic Acid	202-205	mitogen-activated protein kinase 1	Homo sapiens	42-46
15865443-2	2005	Previous studies have shown that p42(mapk/erk2) phosphorylates Ser and Thr residues (T236, S240, S244, and S270) in the membrane proximal region of TNF-R1 and that mutation of these residues to Glu and Asp residues (TNF-R1.4D/E) mimics the effect of phosphorylation on receptor signaling and localization.	Aspartic Acid	202-205	TNF receptor superfamily member 1A	Homo sapiens	148-154
15661745-2	2005	In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)).	Aspartic Acid	247-250	complement C5a receptor 1	Homo sapiens	61-65
15661745-2	2005	In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)).	Aspartic Acid	247-250	complement C5a receptor 1	Homo sapiens	61-64
15661745-10	2005	Asp(282) has been previously shown to interact with the side chain of the C-terminal Arg residue, and Glu(199) may also interact with this side chain in both C5a and peptide mimics.	Aspartic Acid	0-3	complement C5a receptor 1	Homo sapiens	158-161
15809717-2	2005	Caspase-1 (interleukin-1beta-converting enzyme) is a member of the cysteine protease family, which cleaves target proteins following aspartic acid residues.	Aspartic Acid	133-146	caspase 1	Homo sapiens	11-46
15743772-6	2005	Here, we report a comprehensive structure-activity examination of potential IRF7 phosphorylation sites through analysis of mutant proteins in which specific serine residues were altered to alanine or aspartate.	Aspartic Acid	200-209	interferon regulatory factor 7	Homo sapiens	76-80
15898744-6	2005	The FP assay was successfully applied to measure the binding affinity to integrin alpha(v)beta(3) of several cyclic peptides containing the Arg-Gly-Asp (RGD) motif.	Aspartic Acid	148-151	integrin subunit alpha V	Homo sapiens	73-97
15977068-4	2005	As a result, DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47), recently identified as RNA helicase, is identified as a binding partner of GABARAP.	Aspartic Acid	31-34	DEAD-box helicase 47	Homo sapiens	60-66
15977068-4	2005	As a result, DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47), recently identified as RNA helicase, is identified as a binding partner of GABARAP.	Aspartic Acid	31-34	GABA type A receptor-associated protein	Homo sapiens	144-151
15753084-12	2005	The results substantiate the hypothesis that intramitochondrial arginase, presumably the arginase-II isozyme, may play an important role in the regulation of hepatic ureagenesis by furnishing ornithine for net synthesis of N-acetylglutamate, citrulline, and aspartate.	Aspartic Acid	258-267	arginase 2	Rattus norvegicus	89-100
15615843-4	2005	The excitatory amino acid transporter type 1 (EAAT1) functions as a glutamate carrier in the malate/aspartate shuttle.	Aspartic Acid	100-109	solute carrier family 1 member 3	Rattus norvegicus	46-51
15615843-17	2005	The 49% increase in EAAT1 mitochondrial protein level shows that malate/aspartate shuttle activity increased in hyperthyroid rat cardiac mitochondria.	Aspartic Acid	72-81	solute carrier family 1 member 3	Rattus norvegicus	20-25
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Aspartic Acid	88-91	GABA type A receptor-associated protein	Homo sapiens	0-33
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Aspartic Acid	88-91	GABA type A receptor-associated protein	Homo sapiens	35-42
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Aspartic Acid	88-91	DEAD-box helicase 47	Homo sapiens	129-135
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Aspartic Acid	100-103	GABA type A receptor-associated protein	Homo sapiens	0-33
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Aspartic Acid	100-103	GABA type A receptor-associated protein	Homo sapiens	35-42
15977068-0	2005	GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).	Aspartic Acid	100-103	DEAD-box helicase 47	Homo sapiens	129-135
15977068-4	2005	As a result, DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47), recently identified as RNA helicase, is identified as a binding partner of GABARAP.	Aspartic Acid	19-22	DEAD-box helicase 47	Homo sapiens	60-66
15977068-4	2005	As a result, DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47), recently identified as RNA helicase, is identified as a binding partner of GABARAP.	Aspartic Acid	19-22	GABA type A receptor-associated protein	Homo sapiens	144-151
15820770-9	2005	RESULTS: The frequencies of the Asp/Glu and Glu/Glu were significantly increased in diabetic subjects with detectable IA-2 antibodies (P &lt; 0.01).	Aspartic Acid	32-35	protein tyrosine phosphatase receptor type N	Homo sapiens	118-122
15809717-2	2005	Caspase-1 (interleukin-1beta-converting enzyme) is a member of the cysteine protease family, which cleaves target proteins following aspartic acid residues.	Aspartic Acid	133-146	caspase 1	Homo sapiens	0-9
15857387-4	2005	The integrin ligand peptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) induced rapid (within 5 min) and robust increases in tyrosine phosphorylation of focal adhesion kinase, proline-rich tyrosine kinase 2 and Src family kinases.	Aspartic Acid	40-43	protein tyrosine kinase 2 beta	Rattus norvegicus	165-195
16027975-1	2005	Four amino acids were variable between the "active" indica-type and "inactive" japonica-type soluble starch synthase IIa (SSIIa) of rice plants; Glu-88 and Gly-604 in SSIIa of indica-cultivars IR36 and Kasalath were replaced by Asp-88 and Ser-604, respectively, in both japonica cultivars Nipponbare and Kinmaze SSIIa, whereas Val-737 and Leu-781 in indica SSIIa were replaced by Met-737 in cv.	Aspartic Acid	228-231	soluble starch synthase 2-3, chloroplastic/amyloplastic	Oryza sativa Japonica Group	101-120
15834418-5	2005	In contrast, altering Ser129 to the negatively charged residue aspartate, to mimic phosphorylation, significantly enhances alpha-synuclein toxicity.	Aspartic Acid	63-72	synuclein alpha	Homo sapiens	123-138
15858043-2	2005	Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.	Aspartic Acid	22-31	Friend virus susceptibility 1	Mus musculus	75-78
15858043-2	2005	Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.	Aspartic Acid	22-31	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	137-141
15767264-1	2005	In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1).	Aspartic Acid	105-108	histidine kinase 2	Arabidopsis thaliana	243-247
15767264-1	2005	In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1).	Aspartic Acid	105-108	histidine kinase 3	Arabidopsis thaliana	249-253
15767264-1	2005	In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1).	Aspartic Acid	105-108	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	258-262
15767264-1	2005	In Arabidopsis thaliana, AUTHENTIC RESPONSE REGULATORS (ARRs) act as downstream components of the His-to-Asp phosphorelay (two-component) signaling pathway that is propagated primarily by the cytokinin receptor kinases, AUTHENTIC HIS-KINASES (AHK2, AHK3 and AHK4/CRE1).	Aspartic Acid	105-108	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	263-267
15723349-6	2005	This is induced by the replacement of a conserved Asp, Asn, or Glu residue by a Pro at one side of the N-Src loop.	Aspartic Acid	50-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
15879716-6	2005	When we replaced the serine 2 and tyrosine 6 of this N-terminal motif with alanine, over-expression of the alanine-replaced BAF53 strongly impaired the growth of HEK293 cells whereas replacement with aspartate/glutamate had no effect.	Aspartic Acid	200-209	actin like 6A	Homo sapiens	124-129
15713684-4	2005	GrB cleaves Mcl-1 after aspartic acid residues 117, 127, and 157, generating C-terminal fragments that all contain BH-1, BH-2, BH-3, and transmembrane domains.	Aspartic Acid	24-37	granzyme B	Homo sapiens	0-3
15713684-4	2005	GrB cleaves Mcl-1 after aspartic acid residues 117, 127, and 157, generating C-terminal fragments that all contain BH-1, BH-2, BH-3, and transmembrane domains.	Aspartic Acid	24-37	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	12-17
15973494-2	2005	The G. orientalis SOD1 (GoSOD1) cDNA contains an open reading frame of 462 bp encoding 154 amino acid polypeptide with a predicted molecular mass of 15.8 kDa and pI of 6.1, and possesses the typical metal binding ligands of six histidines and one aspartic acid common to SOD1s.	Aspartic Acid	247-260	superoxide dismutase 1	Apis mellifera	18-22
15695505-2	2005	Arginines B13 and B17 are each chelated by an aspartic acid/glutamic acid pair and by isoleucine B20, which, offset by a one-quarter helix turn from a straight line connecting the arginines, interacts with a cluster of hydrophobic amino acids.	Aspartic Acid	46-59	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	10-13
15695505-2	2005	Arginines B13 and B17 are each chelated by an aspartic acid/glutamic acid pair and by isoleucine B20, which, offset by a one-quarter helix turn from a straight line connecting the arginines, interacts with a cluster of hydrophobic amino acids.	Aspartic Acid	46-59	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	18-21
15771721-2	2005	Two other SNPs (CRH A145G and C240G) occur in the propeptide region at residue positions 45 and 77, respectively, that result in serine/asparagine and histidine/aspartic acid substitutions respectively.	Aspartic Acid	161-174	corticotropin releasing hormone	Bos taurus	16-19
15823605-9	2005	Substitution of the aspartic acid at position 61 and glutamic acid at position 63 in the SIV(cpz) ANT Vpu within with lysine residues abolished the ability of this protein to down-modulate cell surface expression of CD4.	Aspartic Acid	20-33	solute carrier family 25 member 6	Homo sapiens	98-101
15784740-2	2005	ASPA acts to hydrolyze N-acetylaspartate (NAA) into l-aspartate and acetate, but the connection between ASPA deficiency and the failure of proper CNS development is unclear.	Aspartic Acid	52-63	aspartoacylase	Homo sapiens	0-4
16511050-5	2005	There are no known structures of a multi-domain ASP and in an effort to remedy this situation, recombinant Na-ASP-1 has been expressed, purified and crystallized.	Aspartic Acid	48-51	beta-secretase 2	Homo sapiens	110-115
15653696-10	2005	The HC.TSG-6 cross-links were different from the PGP cross-link and were determined to be ester bonds between the alpha-carbonyl of the C-terminal Asp of the heavy chain and most likely a hydroxyl group containing the TSG-6 residue.	Aspartic Acid	147-150	TNF alpha induced protein 6	Homo sapiens	7-12
15811564-1	2005	A commonly occurring nucleotide polymorphism of the insulin-receptor substrate 2 (IRS-2) gene at amino acid 1057 from Glycine to Asparaginic acid (G1057D) was recently shown to be a determinant of insulin sensitivity in both glucose-tolerant individuals and those with type 2 diabetes.	Aspartic Acid	129-145	insulin receptor substrate 2	Homo sapiens	52-80
15811564-1	2005	A commonly occurring nucleotide polymorphism of the insulin-receptor substrate 2 (IRS-2) gene at amino acid 1057 from Glycine to Asparaginic acid (G1057D) was recently shown to be a determinant of insulin sensitivity in both glucose-tolerant individuals and those with type 2 diabetes.	Aspartic Acid	129-145	insulin receptor substrate 2	Homo sapiens	82-87
15811564-1	2005	A commonly occurring nucleotide polymorphism of the insulin-receptor substrate 2 (IRS-2) gene at amino acid 1057 from Glycine to Asparaginic acid (G1057D) was recently shown to be a determinant of insulin sensitivity in both glucose-tolerant individuals and those with type 2 diabetes.	Aspartic Acid	129-145	insulin	Homo sapiens	52-59
15762878-4	2005	Two lines from HLA-B*3501(+) donors were found to be strongly cytotoxic to autologous Asp f16-peptide pool- and Aspergillus culture extract-pulsed targets after 4-5 weekly primings.	Aspartic Acid	86-89	major histocompatibility complex, class I, B	Homo sapiens	15-20
15804608-4	2005	The deglycosylation reaction by PNGase brings about two major changes on substrate the peptide; one is removal of the N-glycan chain and the other is the introduction of a negative charge into the core peptide by converting the glycosylated asparagine residue(s) into an aspartic acid residue(s).	Aspartic Acid	271-284	N-glycanase 1	Homo sapiens	32-38
15653696-12	2005	A TSG-6 hydroxyl group reacts with the ester bond between the alpha-carbonyl of the C-terminal Asp residues of HC1 or HC2 and carbon-6 of an internal N-acetylgalactosamine of the chondroitin-4-sulfate chain.	Aspartic Acid	95-98	TNF alpha induced protein 6	Homo sapiens	2-7
15653696-12	2005	A TSG-6 hydroxyl group reacts with the ester bond between the alpha-carbonyl of the C-terminal Asp residues of HC1 or HC2 and carbon-6 of an internal N-acetylgalactosamine of the chondroitin-4-sulfate chain.	Aspartic Acid	95-98	CYCS pseudogene 39	Homo sapiens	111-114
15653696-12	2005	A TSG-6 hydroxyl group reacts with the ester bond between the alpha-carbonyl of the C-terminal Asp residues of HC1 or HC2 and carbon-6 of an internal N-acetylgalactosamine of the chondroitin-4-sulfate chain.	Aspartic Acid	95-98	CYCS pseudogene 38	Homo sapiens	118-121
15637055-3	2005	Here we showed that, besides the specific cleavage and activation of Bid by caspase-8 and caspase-3, TRAIL-induced apoptosis in Jurkat T cells required the specific cleavage of Mcl-1 at Asp-127 and Asp-157 by caspase-3, while other prototypic antiapoptotic factors such as Bcl-2 or Bcl-X(L) seemed not to be affected.	Aspartic Acid	186-189	TNF superfamily member 10	Homo sapiens	101-106
15590655-4	2005	An additional step, the disruption of an electrostatic bond formed between Asp-33 (halpha1) and Lys-64 (BH3), allows the mitochondria addressing of Bax.	Aspartic Acid	75-78	BCL2 associated X, apoptosis regulator	Homo sapiens	148-151
15632178-4	2005	Aspartic acid substitution of Thr(566), which is phosphorylated in mitotic or okadaic acid-treated cells, is sufficient to abolish F-actin-mediated inhibition and to maintain Abl activity despite cell detachment.	Aspartic Acid	0-13	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	175-178
15637055-3	2005	Here we showed that, besides the specific cleavage and activation of Bid by caspase-8 and caspase-3, TRAIL-induced apoptosis in Jurkat T cells required the specific cleavage of Mcl-1 at Asp-127 and Asp-157 by caspase-3, while other prototypic antiapoptotic factors such as Bcl-2 or Bcl-X(L) seemed not to be affected.	Aspartic Acid	186-189	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	177-182
15637055-4	2005	Mutation at Asp-127 and Asp-157 of Mcl-1 led to cellular resistance to TRAIL-induced apoptosis.	Aspartic Acid	12-15	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	35-40
15637055-4	2005	Mutation at Asp-127 and Asp-157 of Mcl-1 led to cellular resistance to TRAIL-induced apoptosis.	Aspartic Acid	12-15	TNF superfamily member 10	Homo sapiens	71-76
15637055-4	2005	Mutation at Asp-127 and Asp-157 of Mcl-1 led to cellular resistance to TRAIL-induced apoptosis.	Aspartic Acid	24-27	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	35-40
15637055-4	2005	Mutation at Asp-127 and Asp-157 of Mcl-1 led to cellular resistance to TRAIL-induced apoptosis.	Aspartic Acid	24-27	TNF superfamily member 10	Homo sapiens	71-76
15688025-5	2005	Mutation of the MK2 phosphorylation sites in HDM2 to aspartic acid renders HDM2 slightly more active in the degradation of p53, and mouse cells deficient for MK2 show reduced Mdm2 phosphorylation and elevated levels of p53 protein.	Aspartic Acid	53-66	MAP kinase-activated protein kinase 2	Mus musculus	16-19
15688025-5	2005	Mutation of the MK2 phosphorylation sites in HDM2 to aspartic acid renders HDM2 slightly more active in the degradation of p53, and mouse cells deficient for MK2 show reduced Mdm2 phosphorylation and elevated levels of p53 protein.	Aspartic Acid	53-66	transformation related protein 53, pseudogene	Mus musculus	123-126
15582990-4	2005	The unfavorable contributions to binding disappear and the number of residues promoting the thrombin-protein C interaction is reduced to Tyr-60a and Asp-189.	Aspartic Acid	149-152	coagulation factor II, thrombin	Homo sapiens	92-100
15854340-4	2005	High performance liquid chromatography was employed to monitor the continuous changes of glutamic acid (Glu), aspartic acid (Asp), Tau and glycine (Gly) in the hippocampus CA1 region at anaesthesia periods, CPB stage, pre 30 minutes in DHCA, post 30 minutes in DHCA, pre 30 minutes in rewarming, post 30 minutes in rewarming.	Aspartic Acid	110-123	carbonic anhydrase 1	Oryctolagus cuniculus	172-175
15854340-4	2005	High performance liquid chromatography was employed to monitor the continuous changes of glutamic acid (Glu), aspartic acid (Asp), Tau and glycine (Gly) in the hippocampus CA1 region at anaesthesia periods, CPB stage, pre 30 minutes in DHCA, post 30 minutes in DHCA, pre 30 minutes in rewarming, post 30 minutes in rewarming.	Aspartic Acid	125-128	carbonic anhydrase 1	Oryctolagus cuniculus	172-175
15736973-0	2005	Spontaneous chemical reversion of an active site mutation: deamidation of an asparagine residue replacing the catalytic aspartic acid of glutamate dehydrogenase.	Aspartic Acid	120-133	glutamate dehydrogenase	Escherichia coli	137-160
15736973-1	2005	A mutant (D165N) of clostridial glutamate dehydrogenase (GDH) in which the catalytic Asp is replaced by Asn surprisingly showed a residual 2% of wild-type activity when purified after expression in Escherichia coli at 37 degrees C. This low-level activity also displayed Michaelis constants for substrates that were remarkably similar to those of the wild-type enzyme.	Aspartic Acid	85-88	glutamate dehydrogenase	Escherichia coli	32-55
15736973-1	2005	A mutant (D165N) of clostridial glutamate dehydrogenase (GDH) in which the catalytic Asp is replaced by Asn surprisingly showed a residual 2% of wild-type activity when purified after expression in Escherichia coli at 37 degrees C. This low-level activity also displayed Michaelis constants for substrates that were remarkably similar to those of the wild-type enzyme.	Aspartic Acid	85-88	glutamate dehydrogenase	Escherichia coli	57-60
15738418-6	2005	Analysis of mutants in which the F-peptide serines were replaced by aspartic acids or alanines showed that F-peptide phosphorylation is required for the subcellular redistribution of hnRNP A1 in cells subjected to OSM.	Aspartic Acid	68-82	heterogeneous nuclear ribonucleoprotein A1	Mus musculus	183-191
15743835-5	2005	The human and the mouse prosaposin gene has a 9-bp exon (exon 8) that is alternatively spliced, resulting in an isoform with three extra amino acids, Gln-Asp-Gln, within the saposin B domain.	Aspartic Acid	154-157	prosaposin	Mus musculus	24-34
15615722-4	2005	On the one hand, it supports intercellular adhesion molecule 1 (ICAM-1) binding to alpha(M)beta(2) directly as part of a recognition interface formed by five noncontiguous segments (Pro(192)-Glu(197), Asn(213)-Glu(220), Leu(225)-Leu(230), Ser(324)-Thr(329), and Glu(344)-Asp(348)) on the apex of the beta(2)I domain.	Aspartic Acid	271-274	intercellular adhesion molecule 1	Homo sapiens	29-62
15615722-4	2005	On the one hand, it supports intercellular adhesion molecule 1 (ICAM-1) binding to alpha(M)beta(2) directly as part of a recognition interface formed by five noncontiguous segments (Pro(192)-Glu(197), Asn(213)-Glu(220), Leu(225)-Leu(230), Ser(324)-Thr(329), and Glu(344)-Asp(348)) on the apex of the beta(2)I domain.	Aspartic Acid	271-274	intercellular adhesion molecule 1	Homo sapiens	64-70
15618217-9	2005	The replacement of these positions by positively charged residues results in a strong growth defect, which can be cured by reverting two conserved positive charges into aspartate residues between transmembrane domains two and three of Tim17.	Aspartic Acid	169-178	translocase of inner mitochondrial membrane 17A	Homo sapiens	235-240
15542581-2	2005	Mutation of the aspartic acid residue encoded by codon 816 of human c-kit or codon 814 of the murine gene results in an oncogenic form of Kit.	Aspartic Acid	16-29	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	68-73
15542581-2	2005	Mutation of the aspartic acid residue encoded by codon 816 of human c-kit or codon 814 of the murine gene results in an oncogenic form of Kit.	Aspartic Acid	16-29	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	138-141
15809331-9	2005	Furthermore, we examined the roles of Asp(36), Ser(124), His(145), Glu(157 )and Asn(196) in the catalytic function of rabbit GDH by site-directed mutagenesis.	Aspartic Acid	38-41	lambda-crystallin	Oryctolagus cuniculus	125-128
15734482-12	2005	Of various types of K-ras mutations, 12 Asp often was seen in type 1 and 2 gastric cancers (well-demarcated, elevated tumors), while 12 Val and 12 Ser were often seen in type 3 and 4 cases (infiltrating carcinomas).	Aspartic Acid	40-43	KRAS proto-oncogene, GTPase	Homo sapiens	20-25
15565427-2	2005	Exposure of mouse cerebellar granule cells to excitotoxic concentrations of glutamate (Glu) and aspartate (Asp) led to a changed time profile for mRNA expression, from a transient c-fos expression at 15-30 min to a delayed, elevated and sustained expression at later time points which was prevented by selective antagonism of the NMDA receptor but not of the AMPA/kainate receptor demonstrating that this c-fos induction was mediated through the specific activation of the NMDA Glu receptor subtype.	Aspartic Acid	96-105	FBJ osteosarcoma oncogene	Mus musculus	180-185
15565427-2	2005	Exposure of mouse cerebellar granule cells to excitotoxic concentrations of glutamate (Glu) and aspartate (Asp) led to a changed time profile for mRNA expression, from a transient c-fos expression at 15-30 min to a delayed, elevated and sustained expression at later time points which was prevented by selective antagonism of the NMDA receptor but not of the AMPA/kainate receptor demonstrating that this c-fos induction was mediated through the specific activation of the NMDA Glu receptor subtype.	Aspartic Acid	96-105	FBJ osteosarcoma oncogene	Mus musculus	405-410
15565427-2	2005	Exposure of mouse cerebellar granule cells to excitotoxic concentrations of glutamate (Glu) and aspartate (Asp) led to a changed time profile for mRNA expression, from a transient c-fos expression at 15-30 min to a delayed, elevated and sustained expression at later time points which was prevented by selective antagonism of the NMDA receptor but not of the AMPA/kainate receptor demonstrating that this c-fos induction was mediated through the specific activation of the NMDA Glu receptor subtype.	Aspartic Acid	107-110	FBJ osteosarcoma oncogene	Mus musculus	180-185
15565427-2	2005	Exposure of mouse cerebellar granule cells to excitotoxic concentrations of glutamate (Glu) and aspartate (Asp) led to a changed time profile for mRNA expression, from a transient c-fos expression at 15-30 min to a delayed, elevated and sustained expression at later time points which was prevented by selective antagonism of the NMDA receptor but not of the AMPA/kainate receptor demonstrating that this c-fos induction was mediated through the specific activation of the NMDA Glu receptor subtype.	Aspartic Acid	107-110	FBJ osteosarcoma oncogene	Mus musculus	405-410
15737330-3	2005	In the present study, a brief exposure to ET-1 was found to increase aspartate uptake in C6 glioma cells, which endogenously express the neuronal glutamate transporter EAAC1 (pEC50 of 9.89).	Aspartic Acid	69-78	endothelin 1	Homo sapiens	42-46
15737330-3	2005	In the present study, a brief exposure to ET-1 was found to increase aspartate uptake in C6 glioma cells, which endogenously express the neuronal glutamate transporter EAAC1 (pEC50 of 9.89).	Aspartic Acid	69-78	solute carrier family 1 member 1	Homo sapiens	168-173
15737330-8	2005	Hence, the disruption of the cytoskeleton with cytochalasin D prevented ET-1-stimulated aspartate uptake.	Aspartic Acid	88-97	endothelin 1	Homo sapiens	72-76
15809332-5	2005	Each protein contained a pair of active site motifs (Asp/Thr or Ser/Gly), which is a common characteristic of aspartic proteases including BACE1.	Aspartic Acid	53-56	beta-secretase 1	Homo sapiens	139-144
15705949-3	2005	The Arabidopsis PSEUDO-RESPONSE REGULATOR (PRR) genes, including the clock component TIMING OF CAB EXPRESSION 1/PRR1, are related to bacterial, fungal, and plant response regulators but lack the conserved Asp that is normally phosphorylated by an upstream sensory kinase.	Aspartic Acid	205-208	AT2G10070	Arabidopsis thaliana	16-22
16018581-3	2005	Superfusion of hippocampal slices revealed that basal levels of tyrosine, aspartate and glutamate release were significantly increased while K+ -evoked release of glutamate and GABA were significantly decreased in lpa1(-/-) mice.	Aspartic Acid	74-83	lysophosphatidic acid receptor 1	Mus musculus	214-218
15705949-3	2005	The Arabidopsis PSEUDO-RESPONSE REGULATOR (PRR) genes, including the clock component TIMING OF CAB EXPRESSION 1/PRR1, are related to bacterial, fungal, and plant response regulators but lack the conserved Asp that is normally phosphorylated by an upstream sensory kinase.	Aspartic Acid	205-208	CCT motif -containing response regulator protein	Arabidopsis thaliana	85-111
15583008-4	2005	The largest shifts in both K(+) and Ca(2+) dependences compared with wild-type NCKX2 were observed for the charge-conservative substitutions of Glu(188) and Asp(548), whereas the size-conservative substitutions resulted in nonfunctional proteins.	Aspartic Acid	157-160	solute carrier family 24 member 2	Homo sapiens	79-84
15730525-2	2005	DOB*010103 differed from DOB*01010101 only at codon 6 (GAT--&gt;GAC), corresponding to synonymous amino acid change (Asp--&gt;Asp).	Aspartic Acid	117-120	glycine-N-acyltransferase	Homo sapiens	55-58
15730525-2	2005	DOB*010103 differed from DOB*01010101 only at codon 6 (GAT--&gt;GAC), corresponding to synonymous amino acid change (Asp--&gt;Asp).	Aspartic Acid	126-129	glycine-N-acyltransferase	Homo sapiens	55-58
15733845-5	2005	Involvement of serine, glutamic acid, and aspartic acid in the catalytic reaction validates the idea, formulated on the basis of significant amino acid sequence homology and inhibition studies, that TPP I is the first mammalian representative of a growing family of serine-carboxyl peptidases.	Aspartic Acid	42-55	tripeptidyl peptidase 1	Homo sapiens	199-204
15572035-1	2005	We screened for genes specifically expressed in the mesenchymes of developing hair follicles using representational differential analysis; one gene identified was MAEG, which encodes a protein consisting of five EGF-like repeats, a linker segment containing a cell-adhesive Arg-Gly-Asp (RGD) motif, and a MAM domain.	Aspartic Acid	282-285	EGF-like-domain, multiple 6	Mus musculus	163-167
15611131-4	2005	We previously reported that dEAAT2 shows unique substrate discrimination as it mediates high affinity transport of aspartate but not glutamate.	Aspartic Acid	115-124	Excitatory amino acid transporter 2	Drosophila melanogaster	28-34
15611132-4	2005	Charge-removing replacement of Asp(575) by either asparagine or cysteine rendered the mutant NCKX2 proteins independent of K(+), whereas the charge-conservative substitution of Asp(575) to glutamate resulted in a nonfunctional mutant NCKX2 protein, accentuating the critical nature of this residue.	Aspartic Acid	31-34	solute carrier family 24 member 2	Homo sapiens	93-98
15611132-5	2005	Asp(575) is conserved in the NCKX1-5 genes, while an asparagine is found in this position in the three NCX genes, coding for the K(+)-independent Na(+)/Ca(2+) exchanger.	Aspartic Acid	0-3	solute carrier family 24 member 1	Homo sapiens	29-34
15697204-3	2005	A Gly --&gt; Asp mutation at position 54 in MBL is found at a frequency as high as 30% in certain populations and leads to increased susceptibility to infections.	Aspartic Acid	13-16	mannose binding lectin 2	Homo sapiens	44-47
15701688-5	2005	Ubiquitin binds to a hydrophobic and acidic patch on helices alpha1 and alpha2 of the GAT three-helix bundle that includes Asn-223, Leu-227, Glu-230, Met-231, Asp-244, Glu-246, Leu-247, Glu-250, and Leu-251.	Aspartic Acid	159-162	adrenoceptor alpha 1D	Homo sapiens	61-78
15701688-5	2005	Ubiquitin binds to a hydrophobic and acidic patch on helices alpha1 and alpha2 of the GAT three-helix bundle that includes Asn-223, Leu-227, Glu-230, Met-231, Asp-244, Glu-246, Leu-247, Glu-250, and Leu-251.	Aspartic Acid	159-162	glycine-N-acyltransferase	Homo sapiens	86-89
15667217-3	2005	The three-dimensional fit between the A. regius structure and that of the only other known X-ray structure, the porcine osteocalcin, revealed a superposition of the Calpha atoms of their metal chelating residues, Gla and Asp, showing that their spatial distribution is consistent with the interatomic distances of calcium cations in the hydroxyapatite crystals.	Aspartic Acid	221-224	bone gamma-carboxyglutamate protein	Homo sapiens	120-131
15579906-6	2005	Sequence alignments of CPTI with the acyltransferase family of enzymes in the GenBank led to the identification of a putative catalytic triad in CPTI consisting of residues Cys-305, Asp-454, and His-473.	Aspartic Acid	182-185	carnitine palmitoyltransferase 1B	Homo sapiens	23-27
15579906-6	2005	Sequence alignments of CPTI with the acyltransferase family of enzymes in the GenBank led to the identification of a putative catalytic triad in CPTI consisting of residues Cys-305, Asp-454, and His-473.	Aspartic Acid	182-185	carnitine palmitoyltransferase 1B	Homo sapiens	145-149
15660729-6	2005	DRB1*0301-DQA1*0501-DQB1*0201 was the most frequent haplotype in both groups but we found a higher proportion of protective T1D haplotypes and Asp(beta57) in the Ab neg group, but in all the cases in combination with susceptible T1D haplotypes.	Aspartic Acid	143-146	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-4
15659694-2	2005	The requirement for one conserved aspartic acid residue distinguishes the archaeal enzyme from both the Escherichia coli and yeast Sec11 enzymes.	Aspartic Acid	34-47	signal peptidase complex catalytic subunit SEC11	Saccharomyces cerevisiae S288C	131-136
15640800-0	2005	An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.	Aspartic Acid	3-16	asporin	Homo sapiens	40-47
15367577-0	2005	Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter.	Aspartic Acid	51-60	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	72-91
15367577-0	2005	Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter.	Aspartic Acid	51-60	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	173-180
15367577-7	2005	Site-directed mutagenesis study identified two residues (Phe-305 and Asp-318) that were critical in supporting PCN-mediated activation, and simultaneous substitution of both residues abolished the ability of rat PXR to transactivate the CYP3A23 promoter.	Aspartic Acid	69-72	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	212-215
15367577-7	2005	Site-directed mutagenesis study identified two residues (Phe-305 and Asp-318) that were critical in supporting PCN-mediated activation, and simultaneous substitution of both residues abolished the ability of rat PXR to transactivate the CYP3A23 promoter.	Aspartic Acid	69-72	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	237-244
15862947-7	2005	Substitution of these two serines by aspartic acid residues abolished the repression of ERbeta by activated ErbB2/ErbB3.	Aspartic Acid	37-50	estrogen receptor 2	Homo sapiens	88-94
15862947-7	2005	Substitution of these two serines by aspartic acid residues abolished the repression of ERbeta by activated ErbB2/ErbB3.	Aspartic Acid	37-50	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-113
15862947-7	2005	Substitution of these two serines by aspartic acid residues abolished the repression of ERbeta by activated ErbB2/ErbB3.	Aspartic Acid	37-50	erb-b2 receptor tyrosine kinase 3	Homo sapiens	114-119
15706615-4	2005	Under acidic conditions A beta(1-40) undergoes spontaneous cleavage between Asp23-Val24 and to a lesser extent also at two other Asp-X motifs.	Aspartic Acid	76-79	amyloid beta precursor protein	Homo sapiens	24-30
15536493-6	2005	Simultaneously, local administration of the OXT receptor antagonist caused a significant increase in the stress-induced release of the excitatory amino acids glutamate and aspartate, whereas the basal release of these amino acids remained unchanged.	Aspartic Acid	172-181	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	44-47
15640800-3	2005	Here we report a significant association between a polymorphism in the aspartic acid (D) repeat of the gene encoding asporin (ASPN) and osteoarthritis.	Aspartic Acid	71-84	asporin	Homo sapiens	117-124
15640800-3	2005	Here we report a significant association between a polymorphism in the aspartic acid (D) repeat of the gene encoding asporin (ASPN) and osteoarthritis.	Aspartic Acid	71-84	asporin	Homo sapiens	126-130
15668381-4	2005	The structures confirm that SABP2 is a member of the alpha/beta hydrolase superfamily of enzymes, with Ser-81, His-238, and Asp-210 as the catalytic triad.	Aspartic Acid	124-127	salicylic acid-binding protein 2	Nicotiana tabacum	28-33
15659623-6	2005	Overexpression of GH3.6 in the activation-tagged mutant dfl1-D did not significantly alter IAA level but resulted in 3.2- and 4.5-fold more IAA-Asp than in wild-type seedlings and mature leaves, respectively.	Aspartic Acid	144-147	Auxin-responsive GH3 family protein	Arabidopsis thaliana	18-23
15684035-4	2005	Using recombinant proteins, we found uPAR directly binds alpha5beta1 and rather than blocking, renders fibronectin (Fn) binding by alpha5beta1 Arg-Gly-Asp (RGD) resistant.	Aspartic Acid	151-154	fibronectin 1	Homo sapiens	116-118
15500838-1	2005	The activities of the enzymes in the malate-aspartate shuttle were measured in peripheral leucocytes of spontaneous type 1 diabetic dogs and cats treated with insulin injections.	Aspartic Acid	44-53	insulin	Felis catus	159-166
15500838-2	2005	In the diabetic dogs and cats, fasting plasma glucose concentrations were three- or fourfold greater than the control levels in spite of insulin injections and the activities of cytosolic malate dehydrogenase (MDH), one of pivotal enzymes in the malate-aspartate shuttle, were remarkably lower than the controls.	Aspartic Acid	253-262	malate dehydrogenase 1	Felis catus	178-208
15500838-2	2005	In the diabetic dogs and cats, fasting plasma glucose concentrations were three- or fourfold greater than the control levels in spite of insulin injections and the activities of cytosolic malate dehydrogenase (MDH), one of pivotal enzymes in the malate-aspartate shuttle, were remarkably lower than the controls.	Aspartic Acid	253-262	malate dehydrogenase 1	Felis catus	210-213
15670822-6	2005	The possible role of Zn2+ ions and the participation of acidic amino acids Glu and Asp in adenosine deamination catalyzed by ADA2 were shown.	Aspartic Acid	83-86	adenosine deaminase 2	Homo sapiens	125-129
15684035-4	2005	Using recombinant proteins, we found uPAR directly binds alpha5beta1 and rather than blocking, renders fibronectin (Fn) binding by alpha5beta1 Arg-Gly-Asp (RGD) resistant.	Aspartic Acid	151-154	plasminogen activator, urokinase receptor	Homo sapiens	37-41
15556946-8	2005	Mutation of two leucine residues in the NES motif to alanine, or three adjacent Ser/Thr residues to the phosphomimetic Asp, results in constitutively nuclear IRF-5 and suggests that phosphorylation of adjacent Ser/Thr residues may contribute to IRF-5 nuclear accumulation in virus-induced cells.	Aspartic Acid	119-122	interferon regulatory factor 5	Homo sapiens	158-163
15643009-2	2005	Osteopontin (OPN) is a secreted acidic phosphoprotein containing an arginine-glycine-aspartate sequence and has been suggested to play an important role in early cellular immune responses.	Aspartic Acid	85-94	secreted phosphoprotein 1	Homo sapiens	13-16
15507442-2	2005	The recently solved crystal structures of the AID-Ca(V)beta complex in Ca(V)1.1/1.2 have revealed that this interaction occurs through a set of six mostly invariant residues Glu/Asp(6), Leu(7), Gly(9), Tyr(10), Trp(13), and Ile(14) (where the superscript refers to the position of the residue starting with the QQ signature doublet) distributed among three alpha-helical turns in the proximal section of the I-II linker.	Aspartic Acid	178-181	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	71-83
15633197-6	2005	The tripeptide in the aspartic acid 3 forms an inverse gamma-turn structure, which is converted to a beta-turn-like conformation because of the formation of the intramolecular NH .	Aspartic Acid	22-35	amyloid beta precursor protein	Homo sapiens	99-105
16301825-10	2005	Mutation of Ser to Asp or Ala in the putative phosphorylation consensus sequence in KCNQ4 significantly decreased the sensitivity to SGK1-coexpression.	Aspartic Acid	19-22	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	133-137
15642359-6	2005	Furthermore, we show here, using point mutant forms of C-Raf kinases with serine to alanine and serine to aspartic acid substitution, that serines 296 and 301 contribute to negative regulation of C-Raf.	Aspartic Acid	106-119	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	55-60
15642359-6	2005	Furthermore, we show here, using point mutant forms of C-Raf kinases with serine to alanine and serine to aspartic acid substitution, that serines 296 and 301 contribute to negative regulation of C-Raf.	Aspartic Acid	106-119	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	196-201
15643009-2	2005	Osteopontin (OPN) is a secreted acidic phosphoprotein containing an arginine-glycine-aspartate sequence and has been suggested to play an important role in early cellular immune responses.	Aspartic Acid	85-94	secreted phosphoprotein 1	Homo sapiens	0-11
15569629-4	2005	The method was used to determine the apparent dissociation constant, Kapp (+/- SD) of Mg2+ binding to aspartate (22 degrees C, 101.7 +/- 22.5 mmol/l, n = 8; 44 degrees C, 45.2 +/- 8.3 mmol/l, n = 6), citrate (high affinity, 0.33 +/- 0.14 mmol/l, n = 4; low affinity, approximately 80 mmol/l), malate (15.9 +/- 1.0 mmol/l, n = 7) and Ca2+ binding to malate (10.3 +/- 1.1 mmol/l, n = 7).	Aspartic Acid	102-111	mucin 7, secreted	Homo sapiens	86-89
16309371-14	2005	The two missense mutations on exon 2 (96) and (135) cause substitutions of amino acids 53 (Asp-->Glu) and 66 (Glu-->Cys) of the catalase protein.	Aspartic Acid	91-94	catalase	Homo sapiens	128-136
15569629-6	2005	For Mg2+ binding to aspartate, malate and citrate there was no or only limited agreement with the calculated Kapp.	Aspartic Acid	20-29	mucin 7, secreted	Homo sapiens	4-7
15953819-6	2005	P2Y2 receptors, via an RGD (Arg-Gly-Asp) motif in their first extracellular loop, bind to alphavbeta3/beta5 integrins, whereupon P2Y2 receptor activation stimulates integrin signaling pathways that regulate cytoskeletal reorganization and cell motility.	Aspartic Acid	36-39	purinergic receptor P2Y2	Homo sapiens	0-4
15886745-9	2005	Regarding the study of angiogenesis the following have been described: a. antibodies targeting VEGF, labeled with radionuclides emitting beta- and/or gamma-radiation, which can be applied for the diagnosis and possibly, for the treatment of cancer, b. peptide derivatives which contain the amino-acid sequence RGD (Arg-Gly-Asp) and compete for the alpha(nu)beta(3) integrins, with the proteins of the stroma.	Aspartic Acid	323-326	vascular endothelial growth factor A	Homo sapiens	95-99
15934319-10	2005	It was concluded that TNF-alpha could promote the release of glutamate and aspartate from astrocytes, and morphine and naloxone might reduce the release of EAAs in cultured spinal astrocytes induced by TNF-alpha.	Aspartic Acid	75-84	tumor necrosis factor	Rattus norvegicus	22-31
15703453-8	2005	The aspartic acid at position 57 in the DQB1 molecule as in DQB1*0401 is reported to play a role in the resistance to IDDM.	Aspartic Acid	4-17	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	40-44
15703453-8	2005	The aspartic acid at position 57 in the DQB1 molecule as in DQB1*0401 is reported to play a role in the resistance to IDDM.	Aspartic Acid	4-17	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	60-64
16370490-0	2005	Identification of a new delta chain hemoglobin variant in a beta-thalassemia carrier: Hb A2-mumc [delta13(a10)Ala--&gt;Asp].	Aspartic Acid	119-122	hemoglobin subunit alpha 2	Homo sapiens	86-91
16370490-1	2005	We describe a case of beta-thalassemia (thal) trait in which the patient also carries a novel delta chain variant due to a missense mutation at amino acid codon 13 (GCC--&gt;GAC, Ala--&gt;Asp).	Aspartic Acid	188-191	guanylate cyclase 2C	Homo sapiens	165-168
15517394-7	2005	Our results establish that treatment of cultured human dermal fibroblasts with recombinant fibrillin-1 fragments containing the arginine-glycine-aspartic acid (RGD) integrin-binding motif of fibrillin-1 induces up-regulation of MMP-1 and MMP-3.	Aspartic Acid	145-158	fibrillin 1	Homo sapiens	91-102
15517394-7	2005	Our results establish that treatment of cultured human dermal fibroblasts with recombinant fibrillin-1 fragments containing the arginine-glycine-aspartic acid (RGD) integrin-binding motif of fibrillin-1 induces up-regulation of MMP-1 and MMP-3.	Aspartic Acid	145-158	fibrillin 1	Homo sapiens	191-202
16217922-13	2005	An interesting observation is the reduction of DNA damage for workers with high VCM exposure and possessing the XPD Asp/Asn and Asn/Asn genotypes (OR 0.33, 95% CI 0.11-0.95).	Aspartic Acid	116-119	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	112-115
15953819-6	2005	P2Y2 receptors, via an RGD (Arg-Gly-Asp) motif in their first extracellular loop, bind to alphavbeta3/beta5 integrins, whereupon P2Y2 receptor activation stimulates integrin signaling pathways that regulate cytoskeletal reorganization and cell motility.	Aspartic Acid	36-39	purinergic receptor P2Y2	Homo sapiens	129-133
15738658-11	2005	Interestingly, real-time RT-PCR analysis showed that hFOB cultured on hydrophobic substrata, which have downregulated alphav and beta3 integrin subunits, displayed greater steady state mRNA levels of osteopontin, an extracellular matrix (ECM) protein containing the Arg-Gly-Asp (RGD) integrin recognition sequence, than did cells cultured on hydrophilic substrata.	Aspartic Acid	274-277	secreted phosphoprotein 1	Homo sapiens	200-211
15485890-2	2004	The binding of the abundant extracellular matrix ligand fibronectin to integrins alpha(5)beta(1) and alpha(v)beta(3) is known to depend upon the Arg-Gly-Asp (RGD) motif on the tenth fibronectin FIII domain.	Aspartic Acid	153-156	fibronectin 1	Homo sapiens	56-67
15485890-2	2004	The binding of the abundant extracellular matrix ligand fibronectin to integrins alpha(5)beta(1) and alpha(v)beta(3) is known to depend upon the Arg-Gly-Asp (RGD) motif on the tenth fibronectin FIII domain.	Aspartic Acid	153-156	fibronectin 1	Homo sapiens	182-193
15615542-0	2004	Insertion of an aspartic acid moiety into cyclic pseudopeptides: synthesis and biological characterization of potent antagonists for the human Tachykinin NK-2 receptor.	Aspartic Acid	16-29	tachykinin receptor 2	Homo sapiens	154-158
15489227-8	2004	Reconstitution of mutant p65 proteins in p65-deficient fibroblasts that either mimicked phosphorylation (S536D) or preserved a predicted hydrogen bond between Ser-536 and Asp-533 (S536N) revealed that phosphorylation of Ser-536 favors interleukin-8 transcription mediated by TATA-binding protein-associated factor II31, a component of TFIID.	Aspartic Acid	171-174	RELA proto-oncogene, NF-kB subunit	Homo sapiens	25-28
15494407-2	2004	Aralar1 and citrin are two isoforms of the mitochondrial aspartate/glutamate carrier, one key constituent of the malate-aspartate NADH shuttle.	Aspartic Acid	57-66	solute carrier family 25 member 12	Rattus norvegicus	0-7
15494407-2	2004	Aralar1 and citrin are two isoforms of the mitochondrial aspartate/glutamate carrier, one key constituent of the malate-aspartate NADH shuttle.	Aspartic Acid	120-129	solute carrier family 25 member 12	Rattus norvegicus	0-7
15615542-3	2004	The replacement of the succinic moiety with an aspartic acid and the functionalization of its amino group with a wide variety of substituents led to very potent and selective NK-2 antagonists.	Aspartic Acid	47-60	tachykinin receptor 2	Homo sapiens	175-179
15610032-5	2004	The C-terminal of both human and porcine TGFBIp is truncated predominantly after the integrin binding sequence Arg(642)-Gly(643)-Asp(644) (RGD).	Aspartic Acid	129-132	transforming growth factor beta induced	Homo sapiens	41-47
15471876-8	2004	Clearly the Asp(62) causes the most drastic effect on ASL function, whereas the Glu(69) mutation produces only modest change.	Aspartic Acid	12-15	adenylosuccinate lyase	Homo sapiens	54-57
15456757-4	2004	The structure displays an overall fold conserved in the proteolytic domain of Ec-Lon; however, the active site shows uniquely configured catalytic Ser-Lys-Asp residues that are not seen in Ec-Lon, which contains a catalytic dyad.	Aspartic Acid	155-158	putative ATP-dependent Lon protease	Escherichia coli	81-84
15456757-4	2004	The structure displays an overall fold conserved in the proteolytic domain of Ec-Lon; however, the active site shows uniquely configured catalytic Ser-Lys-Asp residues that are not seen in Ec-Lon, which contains a catalytic dyad.	Aspartic Acid	155-158	putative ATP-dependent Lon protease	Escherichia coli	192-195
15456757-6	2004	Consequently, the configurations of the active sites differ due to the formation of a salt bridge between Asp-547 and Lys-593 in Mj-Lon.	Aspartic Acid	106-109	putative ATP-dependent Lon protease	Escherichia coli	132-135
15471876-4	2004	Although both human and B. subtilis enzymes normally have Asp at position 87 (or 69), the B. subtilis ASL has Ile and Asp at 62 and 65, respectively, whereas human ASL has Glu and Arg at the equivalent positions.	Aspartic Acid	118-121	adenylosuccinate lyase	Homo sapiens	102-105
15584761-1	2004	The mammalian heme peroxidases are distinguished from their plant and fungal counterparts by the fact that the heme group is covalently bound to the protein through ester links from glutamate and aspartate residues to the heme 1- and 5-methyl groups and, in the case of myeloperoxidase, through an additional sulfonium link from the Cbeta of the 2-vinyl group to a methionine residue.	Aspartic Acid	196-205	myeloperoxidase	Homo sapiens	270-285
15466476-5	2004	We found that mutation of this residue to alanine eliminated its ability to activate MEK/ERK and NF-kappaB pathways, whereas a phosphomimetic mutation to aspartic acid could rescue the ability to activate MEK.	Aspartic Acid	154-167	mitogen-activated protein kinase kinase 7	Homo sapiens	205-208
15604293-4	2004	Mutation of this phosphorylation site to aspartic acid to mimic constitutive phosphorylation blocks acetylation of the K303 ERalpha site and generates an enhanced transcriptional response similar to that seen with the naturally occurring K303R mutant receptor.	Aspartic Acid	41-54	estrogen receptor 1	Homo sapiens	124-131
15598761-9	2004	To our knowledge, this is the first study assigning breast cancer risk to both the ERCC2 genotype encoding Asp(312)Asp and the haplotype encoding Asp(312)/Gln(751).	Aspartic Acid	107-110	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	83-88
15533321-0	2004	Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced strio-nigral degeneration.	Aspartic Acid	53-67	nitric oxide synthase 2	Rattus norvegicus	8-39
15506972-4	2004	Here we demonstrate, using a c-Myc mutant (V394D, Val(394)--&gt;Asp) that is incapable of binding Miz-1, that c-Myc repression of Nramp1 transcription is dependent on its interaction with Miz-1.	Aspartic Acid	64-67	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	130-136
15522224-6	2004	Mutagenesis of the identified cleavage sites revealed that the mutants D379A, D379L or D379E block the degradation of BACE into the approximately 12kDa product, confirming the importance of Asp(379).	Aspartic Acid	190-193	beta-secretase 1	Homo sapiens	118-122
15588620-0	2004	Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter.	Aspartic Acid	111-120	solute carrier family 6 member 3	Homo sapiens	137-157
15578758-9	2004	This result is in agreement with the previously obtained data from multiple sequence alignment of S. rimosus lipase with different esterases, which indicated that this enzyme exhibits a characteristic Gly-Asp-Ser-(Leu) motif located close to the N-terminus and is harboring the catalytically active serine residue.	Aspartic Acid	205-208	DF17_RS11515	Streptomyces rimosus	109-115
15507397-4	2004	Because HLA-DQB1*0401, *03032 alleles carry aspartic acid at position 57 of DQB, susceptibility to T1DM in Korean children was not related to the presence of aspartic acid at position 57 of DQB1 locus.	Aspartic Acid	44-57	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	8-16
15507397-4	2004	Because HLA-DQB1*0401, *03032 alleles carry aspartic acid at position 57 of DQB, susceptibility to T1DM in Korean children was not related to the presence of aspartic acid at position 57 of DQB1 locus.	Aspartic Acid	44-57	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	12-15
15507397-4	2004	Because HLA-DQB1*0401, *03032 alleles carry aspartic acid at position 57 of DQB, susceptibility to T1DM in Korean children was not related to the presence of aspartic acid at position 57 of DQB1 locus.	Aspartic Acid	44-57	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	12-16
15590823-5	2004	Furthermore, overexpression of AQR1 led to increased excretion of several amino acids (alanine, aspartate, and glutamate) known to be relatively abundant in the cytosol.	Aspartic Acid	96-105	Aqr1p	Saccharomyces cerevisiae S288C	31-35
15495159-0	2004	MHC class I-associated presentation of exogenous peptides is not only enhanced but also prolonged by linking with a C-terminal Lys-Asp-Glu-Leu endoplasmic reticulum retrieval signal.	Aspartic Acid	131-134	major histocompatibility complex, class I, C	Homo sapiens	0-3
15495159-3	2004	In this study, we observed that exogenous peptides that were artificially fused with an endoplasmic reticulum (ER) retrieval signal, a C-terminal Lys-Asp-Glu-Leu sequence, could be efficiently presented by intracellular MHC class I molecules in a TAP- and proteasome-independent, but brefeldin A-sensitive manner.	Aspartic Acid	150-153	major histocompatibility complex, class I, C	Homo sapiens	220-223
15815081-5	2004	This binding orientation of probes I and II is in accordance with the model predicting ion-pairing of the negatively charged side chain of CYP 2B4 Asp 105 and a positively charged nitrogen located in an appropriate position in structures of probes I and II, only.	Aspartic Acid	147-150	cytochrome P450 2B4	Oryctolagus cuniculus	139-146
15537772-15	2004	As FI increased, the SID decreased linearly (P &lt; 0.04) for CP and all AA, except Arg, Trp, Asp, Pro, and Tyr.	Aspartic Acid	94-97	FEEDIN	Sus scrofa	3-5
15494273-3	2004	RESULTS: When lamivudine therapy was commenced, 14 patients (77%) had an increase in their aspartate (AST) and alanine (ALT) aminotransferase levels.	Aspartic Acid	91-100	solute carrier family 17 member 5	Homo sapiens	102-105
15557261-4	2004	The ASM model predicts residues Asp 206, Asp 278, Asn 318, His 425, and His 457 to be dimetal coordinating.	Aspartic Acid	32-35	sphingomyelin phosphodiesterase 1	Homo sapiens	4-7
15557261-4	2004	The ASM model predicts residues Asp 206, Asp 278, Asn 318, His 425, and His 457 to be dimetal coordinating.	Aspartic Acid	41-44	sphingomyelin phosphodiesterase 1	Homo sapiens	4-7
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Aspartic Acid	132-135	matrix metallopeptidase 14	Homo sapiens	188-195
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Aspartic Acid	132-135	complement C1q A chain	Homo sapiens	238-241
15520311-0	2004	Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3.	Aspartic Acid	159-162	angiotensin I converting enzyme	Rattus norvegicus	80-109
15474498-4	2004	An aspartate substituted mutant (S182D), incorporating a negative charge to mimic phosphorylation, displayed only 50% of the transactivation capacity in response to 1,25(OH)2D3 of either wild-type or an S182A-altered hVDR.	Aspartic Acid	3-12	vitamin D receptor	Homo sapiens	217-221
15518541-9	2004	The C-terminal conformational discrepancy between the solution and crystal was caused by the intermolecular hydrogen bond between Tyr 13 of one molecule and Asp 8 of the other in a dimer-like formation of crystalline ET-1.	Aspartic Acid	157-160	endothelin 1	Homo sapiens	217-221
15358788-2	2004	PARN belongs to the DEDD family of nucleases, and four conserved residues are essential for PARN activity, i.e. Asp-28, Glu-30, Asp-292, and Asp-382.	Aspartic Acid	112-115	poly(A)-specific ribonuclease	Homo sapiens	0-4
15358788-2	2004	PARN belongs to the DEDD family of nucleases, and four conserved residues are essential for PARN activity, i.e. Asp-28, Glu-30, Asp-292, and Asp-382.	Aspartic Acid	112-115	poly(A)-specific ribonuclease	Homo sapiens	92-96
15358788-2	2004	PARN belongs to the DEDD family of nucleases, and four conserved residues are essential for PARN activity, i.e. Asp-28, Glu-30, Asp-292, and Asp-382.	Aspartic Acid	128-131	poly(A)-specific ribonuclease	Homo sapiens	0-4
15358788-2	2004	PARN belongs to the DEDD family of nucleases, and four conserved residues are essential for PARN activity, i.e. Asp-28, Glu-30, Asp-292, and Asp-382.	Aspartic Acid	128-131	poly(A)-specific ribonuclease	Homo sapiens	92-96
15358788-2	2004	PARN belongs to the DEDD family of nucleases, and four conserved residues are essential for PARN activity, i.e. Asp-28, Glu-30, Asp-292, and Asp-382.	Aspartic Acid	128-131	poly(A)-specific ribonuclease	Homo sapiens	0-4
15358788-2	2004	PARN belongs to the DEDD family of nucleases, and four conserved residues are essential for PARN activity, i.e. Asp-28, Glu-30, Asp-292, and Asp-382.	Aspartic Acid	128-131	poly(A)-specific ribonuclease	Homo sapiens	92-96
15347660-1	2004	The S1 site (Asp(189)) of factor Xa (fXa) is located on a loop (residues 185-189) that contains three solvent-exposed charged residues (Asp(185), Lys(186), and Glu(188)) below the active-site pocket of the protease.	Aspartic Acid	13-16	coagulation factor X	Homo sapiens	26-35
15347660-1	2004	The S1 site (Asp(189)) of factor Xa (fXa) is located on a loop (residues 185-189) that contains three solvent-exposed charged residues (Asp(185), Lys(186), and Glu(188)) below the active-site pocket of the protease.	Aspartic Acid	13-16	coagulation factor X	Homo sapiens	37-40
15347660-1	2004	The S1 site (Asp(189)) of factor Xa (fXa) is located on a loop (residues 185-189) that contains three solvent-exposed charged residues (Asp(185), Lys(186), and Glu(188)) below the active-site pocket of the protease.	Aspartic Acid	136-139	coagulation factor X	Homo sapiens	26-35
15347660-1	2004	The S1 site (Asp(189)) of factor Xa (fXa) is located on a loop (residues 185-189) that contains three solvent-exposed charged residues (Asp(185), Lys(186), and Glu(188)) below the active-site pocket of the protease.	Aspartic Acid	136-139	coagulation factor X	Homo sapiens	37-40
15377998-2	2004	Here, we report a mutation of glycine to aspartic acid at the second glycine of the GXGXXG motif of Tie2 (G833DTie2) in human intramuscular haemangiomas (IMHs) of the capillary type.	Aspartic Acid	41-54	TEK receptor tyrosine kinase	Homo sapiens	100-104
15500910-1	2004	Adenylosuccinate synthetase (AdSS) catalyses the Mg(2+) dependent formation of adenylosuccinate from IMP and aspartate, the reaction being driven by the hydrolysis of GTP to GDP.	Aspartic Acid	109-118	adenylosuccinate synthetase like 1	Mus musculus	0-27
15517645-11	2004	We found DRB1*0801/DQB1*0402 haplotype to be strongly associated (p &lt; 0.001) with JIA, supporting findings of the haplotype associations-based ASP design.	Aspartic Acid	146-149	major histocompatibility complex, class II, DR beta 1	Homo sapiens	9-13
15517645-11	2004	We found DRB1*0801/DQB1*0402 haplotype to be strongly associated (p &lt; 0.001) with JIA, supporting findings of the haplotype associations-based ASP design.	Aspartic Acid	146-149	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	19-23
15479890-6	2004	In accordance with the reshaped shared epitope hypothesis, all the protective DRB1 alleles in these haplotypes share either isoleucine at position 67 or aspartic acid at position 70 in their third hypervariable region motif.	Aspartic Acid	153-166	major histocompatibility complex, class II, DR beta 1	Homo sapiens	78-82
15500910-1	2004	Adenylosuccinate synthetase (AdSS) catalyses the Mg(2+) dependent formation of adenylosuccinate from IMP and aspartate, the reaction being driven by the hydrolysis of GTP to GDP.	Aspartic Acid	109-118	adenylosuccinate synthetase like 1	Mus musculus	29-33
15516806-8	2004	ASCT2 plays a role in L-isomer-selective aspartic acid efflux transport at the BBB.	Aspartic Acid	41-54	solute carrier family 1 member 5	Homo sapiens	0-5
15252014-7	2004	Because this assay was designed based on data suggesting that SPP has an orientation distinct from presenilin and cleaves type II membrane proteins, we determined whether the segment of SPP located between the two presumptive catalytic aspartates was in the lumen or cytoplasm.	Aspartic Acid	236-246	histocompatibility minor 13	Homo sapiens	186-189
15272021-9	2004	The double mutation of residues Asp-72 and Glu-73 generates a PlGF variant unable to bind and activate the receptor molecules on the cell surface.	Aspartic Acid	32-35	placental growth factor	Homo sapiens	62-66
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Aspartic Acid	318-321	complement C4B (Chido blood group)	Homo sapiens	87-90
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Aspartic Acid	318-321	coiled-coil domain containing 115	Homo sapiens	148-152
15272021-5	2004	The two negatively charged residues, Asp-72 and Glu-73, located in the beta3-beta4 loop, are critical for Flt-1 binding.	Aspartic Acid	37-40	fms related receptor tyrosine kinase 1	Homo sapiens	106-111
15456259-2	2004	There are two aspartic acid residues (Asp 32 and Asp 228) present in the catalytic region of BACE that can adopt multiple protonation states.	Aspartic Acid	14-27	beta-secretase 1	Homo sapiens	93-97
15456259-2	2004	There are two aspartic acid residues (Asp 32 and Asp 228) present in the catalytic region of BACE that can adopt multiple protonation states.	Aspartic Acid	38-41	beta-secretase 1	Homo sapiens	93-97
15456259-2	2004	There are two aspartic acid residues (Asp 32 and Asp 228) present in the catalytic region of BACE that can adopt multiple protonation states.	Aspartic Acid	49-52	beta-secretase 1	Homo sapiens	93-97
15467183-8	2004	ASCT2 plays a role in L-isomer-selective aspartic acid efflux transport at the BBB.	Aspartic Acid	41-54	solute carrier family 1 member 5	Homo sapiens	0-5
15453706-0	2004	ACE-inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [beta-CN f(47-51)].	Aspartic Acid	61-64	angiotensin I converting enzyme	Homo sapiens	0-3
15483745-4	2004	It was found that Glu/Glu, Glu/Asp and Asp/Asp genotype frequencies of the eNOS were 49.3%, 41.3% and 9.3% respectively in the control group, and 45.6%, 41.2% and 13.2% in the patient group.	Aspartic Acid	31-34	nitric oxide synthase 3	Homo sapiens	75-79
15483745-4	2004	It was found that Glu/Glu, Glu/Asp and Asp/Asp genotype frequencies of the eNOS were 49.3%, 41.3% and 9.3% respectively in the control group, and 45.6%, 41.2% and 13.2% in the patient group.	Aspartic Acid	39-42	nitric oxide synthase 3	Homo sapiens	75-79
15483745-4	2004	It was found that Glu/Glu, Glu/Asp and Asp/Asp genotype frequencies of the eNOS were 49.3%, 41.3% and 9.3% respectively in the control group, and 45.6%, 41.2% and 13.2% in the patient group.	Aspartic Acid	39-42	nitric oxide synthase 3	Homo sapiens	75-79
15450853-5	2004	Vibrio PGI contains motifs for the serine, histidine and aspartic acid active sites of the subtilase family of serine proteases which form a putative catalytic triad consisting of His534 and Ser159 on the 60.8-kDa subunit and Asp53 on the 23.4-kDa subunit.	Aspartic Acid	57-70	glucose-6-phosphate isomerase	Oryctolagus cuniculus	7-10
15451168-9	2004	The high sequence identity between man and mouse-much higher as observed for APOBEC-1-indicates a strong evolutionary constraint on the structure-function relationship of ACF/ASP, most probably due to a central role in editing and processing of apo B mRNA.	Aspartic Acid	175-178	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	Mus musculus	77-85
15451168-9	2004	The high sequence identity between man and mouse-much higher as observed for APOBEC-1-indicates a strong evolutionary constraint on the structure-function relationship of ACF/ASP, most probably due to a central role in editing and processing of apo B mRNA.	Aspartic Acid	175-178	APOBEC1 complementation factor	Mus musculus	171-174
15451168-9	2004	The high sequence identity between man and mouse-much higher as observed for APOBEC-1-indicates a strong evolutionary constraint on the structure-function relationship of ACF/ASP, most probably due to a central role in editing and processing of apo B mRNA.	Aspartic Acid	175-178	apolipoprotein B	Mus musculus	245-250
15503227-2	2004	Here, we report the kinetics of Asp racemization in model peptides corresponding to elastin sequences from exons 6 and 26.	Aspartic Acid	32-35	elastin	Homo sapiens	84-91
15503227-4	2004	These results suggest that racemization of Asp residues in elastin could occur within a human life span.	Aspartic Acid	43-46	elastin	Homo sapiens	59-66
15385585-8	2004	These results may indicate that glutamate/aspartate uptake into cardiomyocytes could be mediated by the high-affinity transporters GLT1v and EAAC1.	Aspartic Acid	42-51	solute carrier family 1 member 1	Rattus norvegicus	141-146
15494775-1	2004	BACKGROUND: The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease.	Aspartic Acid	122-131	nitric oxide synthase 3	Homo sapiens	71-75
15494775-1	2004	BACKGROUND: The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease.	Aspartic Acid	122-131	methylenetetrahydrofolate reductase	Homo sapiens	169-204
15494775-1	2004	BACKGROUND: The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease.	Aspartic Acid	122-131	methylenetetrahydrofolate reductase	Homo sapiens	206-211
15494775-1	2004	BACKGROUND: The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease.	Aspartic Acid	133-136	nitric oxide synthase 3	Homo sapiens	71-75
15494775-1	2004	BACKGROUND: The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease.	Aspartic Acid	133-136	methylenetetrahydrofolate reductase	Homo sapiens	169-204
15494775-1	2004	BACKGROUND: The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease.	Aspartic Acid	133-136	methylenetetrahydrofolate reductase	Homo sapiens	206-211
15470257-3	2004	This screen identified a mutation in the HOM6 gene, which encodes homoserine dehydrogenase, the enzyme catalyzing the last step in conversion of aspartic acid into homoserine, the common precursor in threonine and methionine synthesis.	Aspartic Acid	145-158	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	41-45
15470257-3	2004	This screen identified a mutation in the HOM6 gene, which encodes homoserine dehydrogenase, the enzyme catalyzing the last step in conversion of aspartic acid into homoserine, the common precursor in threonine and methionine synthesis.	Aspartic Acid	145-158	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	66-90
15367680-7	2004	A mutant ZIP kinase construct, in which the six serine/threonine residues were mutated to aspartic acid to mimic the phosphorylated state, was found predominantly in the cytoplasm as a trimer and possessed greater cell death-inducing potency.	Aspartic Acid	90-103	death associated protein kinase 3	Homo sapiens	9-19
15367681-8	2004	Mutation at Asp(159) in the acidic patch disrupts Gli1 tethering and repression while not strongly disrupting binding, indicating that the amino-terminal domain of Su(fu) likely impacts Gli binding through a mechanism distinct from that for tethering and repression.	Aspartic Acid	12-15	GLI family zinc finger 1	Homo sapiens	50-54
15367685-9	2004	Interestingly, replacement of T188 with aspartic acid creates a C/EBPbeta molecule (C/EBPbeta T188D) that possesses adipogenic activity similar to that of the wild-type molecule.	Aspartic Acid	40-53	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	64-73
15367685-9	2004	Interestingly, replacement of T188 with aspartic acid creates a C/EBPbeta molecule (C/EBPbeta T188D) that possesses adipogenic activity similar to that of the wild-type molecule.	Aspartic Acid	40-53	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	84-93
15367681-8	2004	Mutation at Asp(159) in the acidic patch disrupts Gli1 tethering and repression while not strongly disrupting binding, indicating that the amino-terminal domain of Su(fu) likely impacts Gli binding through a mechanism distinct from that for tethering and repression.	Aspartic Acid	12-15	SUFU negative regulator of hedgehog signaling	Homo sapiens	164-170
15367681-8	2004	Mutation at Asp(159) in the acidic patch disrupts Gli1 tethering and repression while not strongly disrupting binding, indicating that the amino-terminal domain of Su(fu) likely impacts Gli binding through a mechanism distinct from that for tethering and repression.	Aspartic Acid	12-15	GLI family zinc finger 1	Homo sapiens	50-53
15361141-3	2004	Biochemical analysis in yeast showed that AtLHT2 transports proline and aspartate with high affinity.	Aspartic Acid	72-81	lysine histidine transporter 2	Arabidopsis thaliana	42-48
15361141-4	2004	However, other neutral and acidic amino acids act as strong competitors for proline and aspartate uptake indicating that AtLHT2 generally transports uncharged and negatively charged amino acids.	Aspartic Acid	88-97	lysine histidine transporter 2	Arabidopsis thaliana	121-127
15237104-9	2004	When co-expressed, mutants of TraR with substitutions at Asp-10 complementing mutants with substitutions at Gly-123 for gene activation in an allele-specific manner.	Aspartic Acid	57-60	transcriptional regulator TraR	Agrobacterium tumefaciens	30-34
15292209-5	2004	Here we showed that residue Asp(170), in the putative "A" domain of human PMCA isoform 4xb, plays a critical role in autoinhibition.	Aspartic Acid	28-31	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	74-78
15456828-2	2004	We have used point mutagenesis to determine the functional contributions of the five negatively charged aspartate (Asp) residues that constitute the Ca2+-binding sites in the C2B domain of synaptotagmin I.	Aspartic Acid	104-113	secretoglobin, family 2B, member 24	Mus musculus	175-178
15456828-2	2004	We have used point mutagenesis to determine the functional contributions of the five negatively charged aspartate (Asp) residues that constitute the Ca2+-binding sites in the C2B domain of synaptotagmin I.	Aspartic Acid	104-113	synaptotagmin I	Mus musculus	189-204
15456828-2	2004	We have used point mutagenesis to determine the functional contributions of the five negatively charged aspartate (Asp) residues that constitute the Ca2+-binding sites in the C2B domain of synaptotagmin I.	Aspartic Acid	115-118	secretoglobin, family 2B, member 24	Mus musculus	175-178
15456828-2	2004	We have used point mutagenesis to determine the functional contributions of the five negatively charged aspartate (Asp) residues that constitute the Ca2+-binding sites in the C2B domain of synaptotagmin I.	Aspartic Acid	115-118	synaptotagmin I	Mus musculus	189-204
15258142-7	2004	This is likely because DNA-PKcs with aspartate substitutions at ABCDE sites allow access to DNA ends while retaining affinity for Ku-bound ends and stabilizing recruitment of the XRCC4-ligase IV complex.	Aspartic Acid	37-46	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	23-31
15456828-4	2004	Mutating either the second or third Asp residues of the C2B domain potently inhibited the ability of synaptotagmin I to rescue synchronous release but did not change its ability to suppress asynchronous release.	Aspartic Acid	36-39	secretoglobin, family 2B, member 24	Mus musculus	56-59
15456828-4	2004	Mutating either the second or third Asp residues of the C2B domain potently inhibited the ability of synaptotagmin I to rescue synchronous release but did not change its ability to suppress asynchronous release.	Aspartic Acid	36-39	synaptotagmin I	Mus musculus	101-116
15456828-5	2004	Synaptotagmin I with mutations in the first or fourth Asp residues of the C2B domain partially rescued synchronous release and partially suppressed asynchronous release, whereas neutralizing the fifth Asp residue had no effect on the ability of synaptotagmin I to rescue transmitter release.	Aspartic Acid	54-57	synaptotagmin I	Mus musculus	0-15
15456828-5	2004	Synaptotagmin I with mutations in the first or fourth Asp residues of the C2B domain partially rescued synchronous release and partially suppressed asynchronous release, whereas neutralizing the fifth Asp residue had no effect on the ability of synaptotagmin I to rescue transmitter release.	Aspartic Acid	54-57	secretoglobin, family 2B, member 24	Mus musculus	74-77
15456828-8	2004	For the suppression of asynchronous release, Ca2+ binding to the C2B domain of synaptotagmin I apparently is not necessary because mutation of the second Asp residue inhibits Ca2+ binding, yet still allows this protein to suppress asynchronous release.	Aspartic Acid	154-157	synaptotagmin I	Mus musculus	79-94
15252032-6	2004	The late phase of TRAIL-induced NF-kappaB activation involves caspase mediated cleavage of IkappaBalpha between Asp(31) and Ser(32) residues to generate an N-terminal truncated fragment that is degraded by the proteasome via the N-end rule pathway.	Aspartic Acid	112-115	TNF superfamily member 10	Homo sapiens	18-23
15252032-6	2004	The late phase of TRAIL-induced NF-kappaB activation involves caspase mediated cleavage of IkappaBalpha between Asp(31) and Ser(32) residues to generate an N-terminal truncated fragment that is degraded by the proteasome via the N-end rule pathway.	Aspartic Acid	112-115	caspase 8	Homo sapiens	62-69
15252032-6	2004	The late phase of TRAIL-induced NF-kappaB activation involves caspase mediated cleavage of IkappaBalpha between Asp(31) and Ser(32) residues to generate an N-terminal truncated fragment that is degraded by the proteasome via the N-end rule pathway.	Aspartic Acid	112-115	NFKB inhibitor alpha	Homo sapiens	91-103
15247212-8	2004	Alanine-scanning mutagenesis of the GLUT4 amino terminus demonstrated that Phe(5) and Ile(8) within the FQQI motif and, to a lesser extent, Asp(12)/Gly(13) were necessary for the appropriate initial trafficking following biosynthesis.	Aspartic Acid	140-143	solute carrier family 2 member 4	Homo sapiens	36-41
15254020-0	2004	The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex.	Aspartic Acid	20-29	solute carrier family 25 member 13	Homo sapiens	50-56
15254020-0	2004	The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex.	Aspartic Acid	20-29	translocase of inner mitochondrial membrane 8A	Homo sapiens	97-101
15254020-0	2004	The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex.	Aspartic Acid	20-29	translocase of inner mitochondrial membrane 8A	Homo sapiens	102-108
15254020-0	2004	The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex.	Aspartic Acid	20-29	translocase of inner mitochondrial membrane 13	Homo sapiens	109-115
15254020-3	2004	We have identified a new class of substrates, citrin and aralar1, which are Ca2+-binding aspartate/glutamate carriers (AGCs) of the mitochondrial inner membrane, using cross-linking and immunoprecipitation assays in isolated mitochondria.	Aspartic Acid	89-98	solute carrier family 25 member 13	Homo sapiens	46-52
15150267-8	2004	Using a rational strategy to identify complex epitopes on proteins showing a highly convoluted architecture, this study definitively identifies the amino acids Lys(713)-Asp(717) as being the key residues recognized by IDR/B-specific anti-TPO aAbs in AITD.	Aspartic Acid	169-172	thyroid peroxidase	Homo sapiens	238-241
15210705-4	2004	In Caenorhabditis elegans, mutation of a glycine to an aspartic acid within a conserved GXXXG motif in the fourth transmembrane domain of APH-1 causes a loss of function phenotype.	Aspartic Acid	55-68	Gamma-secretase subunit aph-1	Caenorhabditis elegans	138-143
15362892-3	2004	The results of the present studies, using pull-down and mass spectrometry experiments, suggest that A2AR-D2R heteromerization depends on an electrostatic interaction between an Arg-rich epitope from the I3 of the D2R (217RRRRKR222) and two adjacent Asp residues (DD401-402) or a phosphorylated Ser (S374) residue in the C-tail of the A2AR.	Aspartic Acid	249-252	adenosine A2a receptor	Homo sapiens	100-104
15362892-6	2004	Finally, mass spectometry and pull-down data showed that the Arg-rich D2R epitope binds to two different epitopes from the C-terminal part of the A2AR, containing the two adjacent Asp residues or the phosphorylated Ser residue (388HELKGVCPEPPGLDDPLAQDGAVGS412 and 370SAQEpSQGNT378).	Aspartic Acid	180-183	adenosine A2a receptor	Homo sapiens	146-150
15206906-5	2004	Mutation of Thr315 and Thr333 to alanine in a catalytically inactive mutant PP2Cdelta (H154D) (His154--&gt;Asp) increases the association with RSK2 significantly, whereas mutation to glutamate, mimicking phosphorylation, reduces the binding of RSK2.	Aspartic Acid	107-110	ILK associated serine/threonine phosphatase	Homo sapiens	76-85
15206906-5	2004	Mutation of Thr315 and Thr333 to alanine in a catalytically inactive mutant PP2Cdelta (H154D) (His154--&gt;Asp) increases the association with RSK2 significantly, whereas mutation to glutamate, mimicking phosphorylation, reduces the binding of RSK2.	Aspartic Acid	107-110	ribosomal protein S6 kinase A3	Homo sapiens	143-147
15311153-8	2004	Plasmin generation in the presence of variant fibrinogens was similar, although not identical, to normal, and plasmin generation in the presence of variant fibrins was impaired for the Asp to Ala variants.	Aspartic Acid	185-188	plasminogen	Homo sapiens	110-117
15598896-1	2004	Osteopontin (OPN) is a highly acidic secreted phosphoprotein that binds to cells via an RGD (arginine-glycine-aspartic acid) cell adhesion sequence that recognizes the alphaVbeta3 integrin.	Aspartic Acid	110-123	secreted phosphoprotein 1	Rattus norvegicus	0-11
15352981-2	2004	In AML, two types of mutations in Fms-like tyrosine kinase 3 (FLT3) have been described; internal tandem duplications (ITD) and point mutations at aspartic acid residue 835 (D835).	Aspartic Acid	147-160	fms related receptor tyrosine kinase 3	Homo sapiens	34-60
15352981-2	2004	In AML, two types of mutations in Fms-like tyrosine kinase 3 (FLT3) have been described; internal tandem duplications (ITD) and point mutations at aspartic acid residue 835 (D835).	Aspartic Acid	147-160	fms related receptor tyrosine kinase 3	Homo sapiens	62-66
15283697-1	2004	In this issue of Clinical Science, Agema and co-workers report the results of a genetic association study of eNOS (endothelial nitric oxide synthase) gene polymorphisms (-786T --&gt; C, intron 4b --&gt; a and Glu298 --&gt; Asp) in patients with angiographic CAD (coronary artery disease), and/or prior MI (myocardial infarction) and a group of healthy population-based controls.	Aspartic Acid	223-226	nitric oxide synthase 3	Homo sapiens	115-148
15598896-1	2004	Osteopontin (OPN) is a highly acidic secreted phosphoprotein that binds to cells via an RGD (arginine-glycine-aspartic acid) cell adhesion sequence that recognizes the alphaVbeta3 integrin.	Aspartic Acid	110-123	secreted phosphoprotein 1	Rattus norvegicus	13-16
15332996-3	2004	A 21-kDa fragment of LyGDI, resulting from activated caspase 3-induced cleavage at an N-terminal consensus site following the Asp(18) residue, accumulated at peak quantities between 5 and 12 h after irradiation.	Aspartic Acid	126-129	Rho, GDP dissociation inhibitor (GDI) beta	Mus musculus	21-26
15332996-3	2004	A 21-kDa fragment of LyGDI, resulting from activated caspase 3-induced cleavage at an N-terminal consensus site following the Asp(18) residue, accumulated at peak quantities between 5 and 12 h after irradiation.	Aspartic Acid	126-129	caspase 3	Mus musculus	53-62
15190062-3	2004	However, the active site of this enzyme contains a key amino acid substitution (Glu for Asp) of a residue that interacts with the delta-amino group of ornithine analogs in the x-ray structures of ODC.	Aspartic Acid	88-91	ornithine decarboxylase 1	Homo sapiens	196-199
15314205-7	2004	Purified DNA-PKcs proteins containing serine/threonine to alanine or aspartate mutations at this cluster of autophosphorylation sites were indistinguishable from wild-type (wt) protein with respect to protein kinase activity.	Aspartic Acid	69-78	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	9-17
15205465-5	2004	Of two potential caspase consensus motifs in HDAC4, both lying within a region containing proline-, glutamic acid-, serine-, and threonine-rich (PEST) sequences, we identified, by site-directed mutagenesis, Asp-289 as the prime cleavage site.	Aspartic Acid	207-210	histone deacetylase 4	Homo sapiens	45-50
15218065-5	2004	In both acidic clusters, the first aspartate residue played a more important role in CAII binding than others.	Aspartic Acid	35-44	carbonic anhydrase 2	Homo sapiens	85-89
15192093-7	2004	We also made corin mutants with a single mutation at a conserved Asp residue that coordinates Ca(2+)-binding in LDLR repeats 1, 2, 3, or 4 (D300Y, D336Y, D373Y, and D410Y) and showed that these mutants had approximately 25, approximately 11, approximately 16, and approximately 82% pro-ANP processing activity, respectively.	Aspartic Acid	65-68	corin, serine peptidase	Homo sapiens	13-18
15192093-7	2004	We also made corin mutants with a single mutation at a conserved Asp residue that coordinates Ca(2+)-binding in LDLR repeats 1, 2, 3, or 4 (D300Y, D336Y, D373Y, and D410Y) and showed that these mutants had approximately 25, approximately 11, approximately 16, and approximately 82% pro-ANP processing activity, respectively.	Aspartic Acid	65-68	low density lipoprotein receptor	Homo sapiens	112-116
15249229-3	2004	Comparison of this catalytic domain with those of the mouse homologue, human cytosolic PLA(2) (cPLA(2)), and the plant PLA(2) patatin reveals that an amino acid sequence of a short segment around Asp-627 of iPLA(2)gamma is conserved among these PLA(2)s, in addition to the Ser-483-containing lipase motif; the corresponding serine and aspartate in cPLA(2) and patatin are known to form a catalytic dyad.	Aspartic Acid	196-199	phospholipase A2 group IVA	Homo sapiens	77-93
15249229-4	2004	Since substitution of alanine for either Ser-483 or Asp-627 results in a loss of the PLA(2) activity, we propose that Ser-483 and Asp-627 of human iPLA(2)gamma constitute an active site similar to the Ser-Asp dyad in cPLA(2) and patatin.	Aspartic Acid	130-133	patatin like phospholipase domain containing 8	Homo sapiens	147-159
15249229-3	2004	Comparison of this catalytic domain with those of the mouse homologue, human cytosolic PLA(2) (cPLA(2)), and the plant PLA(2) patatin reveals that an amino acid sequence of a short segment around Asp-627 of iPLA(2)gamma is conserved among these PLA(2)s, in addition to the Ser-483-containing lipase motif; the corresponding serine and aspartate in cPLA(2) and patatin are known to form a catalytic dyad.	Aspartic Acid	196-199	phospholipase A2 group IVA	Homo sapiens	95-102
15249229-3	2004	Comparison of this catalytic domain with those of the mouse homologue, human cytosolic PLA(2) (cPLA(2)), and the plant PLA(2) patatin reveals that an amino acid sequence of a short segment around Asp-627 of iPLA(2)gamma is conserved among these PLA(2)s, in addition to the Ser-483-containing lipase motif; the corresponding serine and aspartate in cPLA(2) and patatin are known to form a catalytic dyad.	Aspartic Acid	196-199	patatin like phospholipase domain containing 8	Homo sapiens	207-219
15249229-3	2004	Comparison of this catalytic domain with those of the mouse homologue, human cytosolic PLA(2) (cPLA(2)), and the plant PLA(2) patatin reveals that an amino acid sequence of a short segment around Asp-627 of iPLA(2)gamma is conserved among these PLA(2)s, in addition to the Ser-483-containing lipase motif; the corresponding serine and aspartate in cPLA(2) and patatin are known to form a catalytic dyad.	Aspartic Acid	196-199	phospholipase A2 group IIA	Homo sapiens	245-252
15249229-3	2004	Comparison of this catalytic domain with those of the mouse homologue, human cytosolic PLA(2) (cPLA(2)), and the plant PLA(2) patatin reveals that an amino acid sequence of a short segment around Asp-627 of iPLA(2)gamma is conserved among these PLA(2)s, in addition to the Ser-483-containing lipase motif; the corresponding serine and aspartate in cPLA(2) and patatin are known to form a catalytic dyad.	Aspartic Acid	196-199	phospholipase A2 group IVA	Homo sapiens	348-355
15249229-3	2004	Comparison of this catalytic domain with those of the mouse homologue, human cytosolic PLA(2) (cPLA(2)), and the plant PLA(2) patatin reveals that an amino acid sequence of a short segment around Asp-627 of iPLA(2)gamma is conserved among these PLA(2)s, in addition to the Ser-483-containing lipase motif; the corresponding serine and aspartate in cPLA(2) and patatin are known to form a catalytic dyad.	Aspartic Acid	335-344	phospholipase A2 group IVA	Homo sapiens	77-93
15249229-3	2004	Comparison of this catalytic domain with those of the mouse homologue, human cytosolic PLA(2) (cPLA(2)), and the plant PLA(2) patatin reveals that an amino acid sequence of a short segment around Asp-627 of iPLA(2)gamma is conserved among these PLA(2)s, in addition to the Ser-483-containing lipase motif; the corresponding serine and aspartate in cPLA(2) and patatin are known to form a catalytic dyad.	Aspartic Acid	335-344	phospholipase A2 group IVA	Homo sapiens	95-102
15249229-4	2004	Since substitution of alanine for either Ser-483 or Asp-627 results in a loss of the PLA(2) activity, we propose that Ser-483 and Asp-627 of human iPLA(2)gamma constitute an active site similar to the Ser-Asp dyad in cPLA(2) and patatin.	Aspartic Acid	52-55	patatin like phospholipase domain containing 8	Homo sapiens	147-159
15249229-4	2004	Since substitution of alanine for either Ser-483 or Asp-627 results in a loss of the PLA(2) activity, we propose that Ser-483 and Asp-627 of human iPLA(2)gamma constitute an active site similar to the Ser-Asp dyad in cPLA(2) and patatin.	Aspartic Acid	130-133	patatin like phospholipase domain containing 8	Homo sapiens	147-159
15282673-8	2004	Molecular analysis revealed that the patient had GCC--&gt;GAC alteration at codon 27 (beta27(B9)Ala--&gt;Asp) causing the abnormal hemoglobin Volga.	Aspartic Acid	105-108	guanylate cyclase 2C	Homo sapiens	49-52
15070828-8	2004	Bovine TKDP-2 had a P1 lysine and the three conserved disulfides, but it possessed an unusual residue (Asp) at P2.	Aspartic Acid	103-106	trophoblast Kunitz domain protein 2	Bos taurus	7-13
15377272-1	2004	A comparative study of secondary specificities of enteropeptidase and trypsin was performed using peptide substrates with general formula A-(Asp/Glu)n-Lys(Arg)-(downward arrow)-B, where n = 1-4.	Aspartic Acid	141-144	transmembrane serine protease 15	Homo sapiens	50-65
15305013-1	2004	Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad.	Aspartic Acid	147-150	phospholipase A2 group X	Homo sapiens	0-26
15305013-1	2004	Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad.	Aspartic Acid	147-150	phospholipase A2 group X	Homo sapiens	28-33
15377272-3	2004	However, in the case of typical enteropeptidase substrates containing four negatively charged Asp/Glu residues at positions P2-P5, electrostatic interaction between these residues and the secondary site Lys99 of the enteropeptidase light chain is the main factor that determines hydrolysis efficiency.	Aspartic Acid	94-97	transmembrane serine protease 15	Homo sapiens	32-47
15377272-3	2004	However, in the case of typical enteropeptidase substrates containing four negatively charged Asp/Glu residues at positions P2-P5, electrostatic interaction between these residues and the secondary site Lys99 of the enteropeptidase light chain is the main factor that determines hydrolysis efficiency.	Aspartic Acid	94-97	transmembrane serine protease 15	Homo sapiens	216-231
15305863-3	2004	The distinct Ca2+ responses are interchangeable by single amino substitution of aspartate for threonine at the corresponding position of the carboxy-terminal cytoplasmic regions of mGluR1 and mGluR5, respectively.	Aspartic Acid	80-89	glutamate receptor, metabotropic 1	Mus musculus	181-187
15291810-7	2004	Consistently, alanine mutation mimicking the nonphosphorylation state abolished the inhibitory effect of Akt on dHAND, whereas aspartate mutation mimicking the phosphorylation state resulted in a loss of dHAND transcriptional activity.	Aspartic Acid	127-136	hand	Drosophila melanogaster	204-209
15044328-5	2004	The adjusted odds ratio for the current smokers with APE1 148Asp/Asp, Asp/Glu and Glu/Glu genotype as compared with the never smokers with the Asp/Asp genotype were 3.01 (95% CI 1.39-6.51, P = 0.005), 2.73 (95% CI 1.29-5.77, P = 0.008) and 7.33 (95% CI 2.93-18.3, P &lt; 0.001), respectively.	Aspartic Acid	61-64	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	53-57
15044328-5	2004	The adjusted odds ratio for the current smokers with APE1 148Asp/Asp, Asp/Glu and Glu/Glu genotype as compared with the never smokers with the Asp/Asp genotype were 3.01 (95% CI 1.39-6.51, P = 0.005), 2.73 (95% CI 1.29-5.77, P = 0.008) and 7.33 (95% CI 2.93-18.3, P &lt; 0.001), respectively.	Aspartic Acid	65-68	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	53-57
15044328-5	2004	The adjusted odds ratio for the current smokers with APE1 148Asp/Asp, Asp/Glu and Glu/Glu genotype as compared with the never smokers with the Asp/Asp genotype were 3.01 (95% CI 1.39-6.51, P = 0.005), 2.73 (95% CI 1.29-5.77, P = 0.008) and 7.33 (95% CI 2.93-18.3, P &lt; 0.001), respectively.	Aspartic Acid	65-68	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	53-57
15044328-5	2004	The adjusted odds ratio for the current smokers with APE1 148Asp/Asp, Asp/Glu and Glu/Glu genotype as compared with the never smokers with the Asp/Asp genotype were 3.01 (95% CI 1.39-6.51, P = 0.005), 2.73 (95% CI 1.29-5.77, P = 0.008) and 7.33 (95% CI 2.93-18.3, P &lt; 0.001), respectively.	Aspartic Acid	65-68	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	53-57
15305863-3	2004	The distinct Ca2+ responses are interchangeable by single amino substitution of aspartate for threonine at the corresponding position of the carboxy-terminal cytoplasmic regions of mGluR1 and mGluR5, respectively.	Aspartic Acid	80-89	glutamate receptor, ionotropic, kainate 1	Mus musculus	192-198
15305863-4	2004	In this investigation, we generated knock-in mice, termed mGluR1 D854T mice, in which aspartate of mGluR1 was replaced with threonine.	Aspartic Acid	86-95	glutamate receptor, metabotropic 1	Mus musculus	58-64
15305863-4	2004	In this investigation, we generated knock-in mice, termed mGluR1 D854T mice, in which aspartate of mGluR1 was replaced with threonine.	Aspartic Acid	86-95	glutamate receptor, metabotropic 1	Mus musculus	99-105
15299133-4	2004	AtPng1p contains the Cys-His-Asp triad present in the TGase catalytic domain.	Aspartic Acid	29-32	peptide-N-glycanase 1	Arabidopsis thaliana	0-7
15208269-6	2004	Consistent with this finding, HNPs bound to and promoted the binding of fibronectin to alpha5beta1 integrin in arginine-glycine-aspartic acid (RGD)-independent manner.	Aspartic Acid	128-141	fibronectin 1	Homo sapiens	72-83
15298678-7	2004	An effect of the Ser phosphorylation was investigated by mutating Ser247 of mCRY1 and Ser265 of mCRY2 to Asp, which resulted in attenuation of each mCRYs" ability to inhibit BMAL1: CLOCK-mediated transcription, whereas a similar mutation at Ser557 of mCRY2 induced no measurable change in its activity.	Aspartic Acid	105-108	cryptochrome 2 (photolyase-like)	Mus musculus	96-101
15298678-7	2004	An effect of the Ser phosphorylation was investigated by mutating Ser247 of mCRY1 and Ser265 of mCRY2 to Asp, which resulted in attenuation of each mCRYs" ability to inhibit BMAL1: CLOCK-mediated transcription, whereas a similar mutation at Ser557 of mCRY2 induced no measurable change in its activity.	Aspartic Acid	105-108	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	174-179
15277579-2	2004	Neutralization of the aspartate near the selectivity filter in the GYGD pore sequence (D292N) of the voltage- and Ca(2+)-activated K+ channel (MaxiK, BKCa) does not prevent conduction like the corresponding mutation in Shaker channel, but profoundly affects major biophysical properties of the channel (Haug, T., D. Sigg, S. Ciani, L. Toro, E. Stefani, and R. Olcese.	Aspartic Acid	22-31	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	143-148
15273299-8	2004	Asp 297-COOH would act as a proton donor for the reaction PQQH(-)--&gt;PQQH, if formed by transfer of the proton from Glu 171-COOH to Asp 297-CO2- in MDH.	Aspartic Acid	0-3	malate dehydrogenase 2	Homo sapiens	150-153
15273299-8	2004	Asp 297-COOH would act as a proton donor for the reaction PQQH(-)--&gt;PQQH, if formed by transfer of the proton from Glu 171-COOH to Asp 297-CO2- in MDH.	Aspartic Acid	134-137	malate dehydrogenase 2	Homo sapiens	150-153
15269832-5	2004	Analysis of 24 healthy subjects showed that subjects with the most common IEF plg phenotype A (n=12) were homozygous for aspartate at position 453 (453D), while both subjects with IEF plg phenotype B were homozygous for asparagine at this position (453N).	Aspartic Acid	121-130	plasminogen	Homo sapiens	78-81
15296730-1	2004	Caspase-1, a mediator of the posttranslational processing of IL-1beta and IL-18, requires an aspartic acid in the P1 position of its substrates.	Aspartic Acid	93-106	caspase 1	Homo sapiens	0-9
15296730-1	2004	Caspase-1, a mediator of the posttranslational processing of IL-1beta and IL-18, requires an aspartic acid in the P1 position of its substrates.	Aspartic Acid	93-106	interleukin 1 beta	Homo sapiens	61-69
15296730-1	2004	Caspase-1, a mediator of the posttranslational processing of IL-1beta and IL-18, requires an aspartic acid in the P1 position of its substrates.	Aspartic Acid	93-106	interleukin 18	Homo sapiens	74-79
15296730-2	2004	The mechanisms of caspase-1 activation remain poorly understood despite numerous structures of the enzyme complexed with aspartate-based inhibitors.	Aspartic Acid	121-130	caspase 1	Homo sapiens	18-27
15296730-5	2004	These results illustrate the essential function of the obligatory aspartate recognition element that opens the active site of caspase-1 to substrates and may be the determinant responsible for the conformational changes between ligand-free and -bound forms of the enzyme, and suggest a new approach for identifying novel aspartic acid mimetics.	Aspartic Acid	66-75	caspase 1	Homo sapiens	126-135
15296730-5	2004	These results illustrate the essential function of the obligatory aspartate recognition element that opens the active site of caspase-1 to substrates and may be the determinant responsible for the conformational changes between ligand-free and -bound forms of the enzyme, and suggest a new approach for identifying novel aspartic acid mimetics.	Aspartic Acid	321-334	caspase 1	Homo sapiens	126-135
15356332-7	2004	The purified ARR22 protein had the ability to undergo phosphorylation in vitro, when incubated with phospho-AHP5, indicating that ARR22 has the fundamental ability to participate into a His-Asp phosphorelay pathway in its own right.	Aspartic Acid	190-193	response regulator 22	Arabidopsis thaliana	13-18
15356332-7	2004	The purified ARR22 protein had the ability to undergo phosphorylation in vitro, when incubated with phospho-AHP5, indicating that ARR22 has the fundamental ability to participate into a His-Asp phosphorelay pathway in its own right.	Aspartic Acid	190-193	response regulator 22	Arabidopsis thaliana	130-135
15356332-12	2004	These results suggested that ARR22 might also be implicated, directly or indirectly, in the cytokinin-responsive His--&gt;Asp phophorelay signal transduction.	Aspartic Acid	122-125	response regulator 22	Arabidopsis thaliana	29-34
15140881-4	2004	Here we identify an evolutionarily conserved region in the amino terminus of PALS1 as the Par6 binding site and identify valine and aspartic acid residues in this region as essential for interacting with the PDZ domain of Par6.	Aspartic Acid	132-145	stardust	Drosophila melanogaster	77-82
15143057-5	2004	The OPCA (OPR, PC, and AID) motif inserted into the ubiquitin fold was presented as a betabetaalpha fold in which the side chains of conserved Asp residues were oriented to the same direction to form an acidic surface.	Aspartic Acid	143-146	ATPase plasma membrane Ca2+ transporting 3	Homo sapiens	4-8
15245898-7	2004	In this first approach, cathepsin L was used to cleave a linker sequence including a cathepsin L site: afrsaaq, thereby releasing the tri-peptide Arg-Gly-Asp (RGD) from the PNA anchor.	Aspartic Acid	154-157	cathepsin L	Homo sapiens	24-35
15245898-7	2004	In this first approach, cathepsin L was used to cleave a linker sequence including a cathepsin L site: afrsaaq, thereby releasing the tri-peptide Arg-Gly-Asp (RGD) from the PNA anchor.	Aspartic Acid	154-157	cathepsin L	Homo sapiens	85-96
15273278-3	2004	By using an in vitro reconstituted replication system comprised of purified proteins, we demonstrate that the conserved Asp-578 and Asp-582 residues of pTP, located close to Ser-580, are important for the initiation activity of the pTP/pol complex.	Aspartic Acid	120-123	regenerating family member 1 alpha	Homo sapiens	152-155
15273278-3	2004	By using an in vitro reconstituted replication system comprised of purified proteins, we demonstrate that the conserved Asp-578 and Asp-582 residues of pTP, located close to Ser-580, are important for the initiation activity of the pTP/pol complex.	Aspartic Acid	120-123	regenerating family member 1 alpha	Homo sapiens	232-235
15273278-3	2004	By using an in vitro reconstituted replication system comprised of purified proteins, we demonstrate that the conserved Asp-578 and Asp-582 residues of pTP, located close to Ser-580, are important for the initiation activity of the pTP/pol complex.	Aspartic Acid	132-135	regenerating family member 1 alpha	Homo sapiens	152-155
15273278-3	2004	By using an in vitro reconstituted replication system comprised of purified proteins, we demonstrate that the conserved Asp-578 and Asp-582 residues of pTP, located close to Ser-580, are important for the initiation activity of the pTP/pol complex.	Aspartic Acid	132-135	regenerating family member 1 alpha	Homo sapiens	232-235
15210149-2	2004	Homoserine dehydrogenase, which reduces aspartate semi-aldehyde to homoserine in a NAD(P)H-dependent reaction, is one such target that is required for the biosynthesis of Met, Thr, and Ile from Asp.	Aspartic Acid	40-49	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	0-24
15140881-4	2004	Here we identify an evolutionarily conserved region in the amino terminus of PALS1 as the Par6 binding site and identify valine and aspartic acid residues in this region as essential for interacting with the PDZ domain of Par6.	Aspartic Acid	132-145	par-6	Drosophila melanogaster	222-226
15194494-0	2004	Aspartate(69) of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2.	Aspartic Acid	0-9	calcitonin receptor	Mus musculus	21-45
15117939-9	2004	Six mutations at Tyr(59), Asp(60), Glu(83), Asp(105), Tyr(106), and Glu(109) either strongly decreased or abolished interaction with both MBL and L-ficolin.	Aspartic Acid	26-29	mannose binding lectin 2	Homo sapiens	138-141
15117939-9	2004	Six mutations at Tyr(59), Asp(60), Glu(83), Asp(105), Tyr(106), and Glu(109) either strongly decreased or abolished interaction with both MBL and L-ficolin.	Aspartic Acid	26-29	ficolin 2	Homo sapiens	146-155
15117939-9	2004	Six mutations at Tyr(59), Asp(60), Glu(83), Asp(105), Tyr(106), and Glu(109) either strongly decreased or abolished interaction with both MBL and L-ficolin.	Aspartic Acid	44-47	mannose binding lectin 2	Homo sapiens	138-141
15117939-9	2004	Six mutations at Tyr(59), Asp(60), Glu(83), Asp(105), Tyr(106), and Glu(109) either strongly decreased or abolished interaction with both MBL and L-ficolin.	Aspartic Acid	44-47	ficolin 2	Homo sapiens	146-155
15123609-6	2004	The substitution of Tyr(1003) with phenylalanine or substitution of either aspartate or arginine residues with alanine impairs c-Cbl-recruitment and ubiquitination of Met and results in the oncogenic activation of the Met receptor.	Aspartic Acid	75-84	Cbl proto-oncogene	Homo sapiens	127-132
15123609-8	2004	Modeling studies suggest the presence of a salt bridge between the aspartate and arginine residues that would position pTyr(1003) for binding to the c-Cbl TKB domain.	Aspartic Acid	67-76	Cbl proto-oncogene	Homo sapiens	149-154
15210149-2	2004	Homoserine dehydrogenase, which reduces aspartate semi-aldehyde to homoserine in a NAD(P)H-dependent reaction, is one such target that is required for the biosynthesis of Met, Thr, and Ile from Asp.	Aspartic Acid	194-197	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	0-24
15150161-6	2004	We demonstrate that the point mutation at arginine 451 and a nonsense mutation at aspartate 396 of neuroligin-3 and -4 (NL3 and NL4), respectively, result in intracellular retention of the mutant proteins.	Aspartic Acid	82-91	neuroligin 3	Homo sapiens	99-118
15194486-2	2004	In the Ang II receptor type AT2, the Asp is conserved (Asp90 in 2nd TMD), however, there is no Tyr residue in the 7th TMD and Phe308 occupies the analogous position to Tyr292 of the AT1.	Aspartic Acid	37-40	angiotensin II receptor type 2 L homeolog	Xenopus laevis	28-31
15194494-0	2004	Aspartate(69) of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2.	Aspartic Acid	0-9	receptor (calcitonin) activity modifying protein 1	Mus musculus	102-147
15219196-7	2004	Interestingly, three different effects were found with the recombinant FXa Gla-mutants for AT-heparin inhibition: (i) Gla--&gt;Asp 14 and 29 were enhanced without calcium; (ii) Gla--&gt;Asp 16 and 26 were not enhanced by calcium; and (iii) Gla--&gt;Asp 19 was essentially the same as wild-type recombinant FXa.	Aspartic Acid	127-130	coagulation factor X	Homo sapiens	71-74
15164092-10	2004	In addition, this study verifies that ASP exerts its functions by acting as an independent ligand that downregulates the melanocyte MC1R and tyrosinase protein in an in vivo system.	Aspartic Acid	38-41	melanocortin 1 receptor	Rattus norvegicus	132-151
15004000-7	2004	treating cells cultured on fibronectin with soluble Arg-Gly-Asp-Ser (RGDS) peptide to specifically block integrin-fibronectin interactions.	Aspartic Acid	60-63	ral guanine nucleotide dissociation stimulator	Homo sapiens	69-73
15004000-7	2004	treating cells cultured on fibronectin with soluble Arg-Gly-Asp-Ser (RGDS) peptide to specifically block integrin-fibronectin interactions.	Aspartic Acid	60-63	fibronectin 1	Homo sapiens	114-125
15242733-10	2004	In myocytes overexpressing EAAT1, activity of the malate/aspartate shuttle increased by 33% compared to non-transfected cells (P = 0.004).	Aspartic Acid	57-66	solute carrier family 1 member 3	Rattus norvegicus	27-32
15242733-11	2004	These data indicate that EAAT1 is expressed in myocardial mitochondria, and functions in the malate/aspartate shuttle, suggesting a role for EAAT1 in myocardial glutamate metabolism.	Aspartic Acid	100-109	solute carrier family 1 member 3	Rattus norvegicus	25-30
15242733-11	2004	These data indicate that EAAT1 is expressed in myocardial mitochondria, and functions in the malate/aspartate shuttle, suggesting a role for EAAT1 in myocardial glutamate metabolism.	Aspartic Acid	100-109	solute carrier family 1 member 3	Rattus norvegicus	141-146
15194785-6	2004	By exploiting this novel trans-complementation approach, we demonstrated, for the first time with infectious virions, that the YMDD aspartates of p66 are both required and sufficient for RT polymerase function.	Aspartic Acid	132-142	DNA polymerase delta 3, accessory subunit	Homo sapiens	146-149
15117953-0	2004	Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens.	Aspartic Acid	16-25	BH3 interacting domain death agonist	Homo sapiens	34-37
15117953-4	2004	Bid is not transcriptionally up-regulated in response to these stimuli but is activated by cleavage on aspartate residues 60 and/or 75, which are the targets of caspase-8 and granzyme B.	Aspartic Acid	103-112	BH3 interacting domain death agonist	Homo sapiens	0-3
15117953-4	2004	Bid is not transcriptionally up-regulated in response to these stimuli but is activated by cleavage on aspartate residues 60 and/or 75, which are the targets of caspase-8 and granzyme B.	Aspartic Acid	103-112	caspase 8	Homo sapiens	161-170
15117953-4	2004	Bid is not transcriptionally up-regulated in response to these stimuli but is activated by cleavage on aspartate residues 60 and/or 75, which are the targets of caspase-8 and granzyme B.	Aspartic Acid	103-112	granzyme B	Homo sapiens	175-185
15208167-8	2004	In the C group, there was a progressive decline in aspartate (AST/ALT) ratios after admission.	Aspartic Acid	51-60	solute carrier family 17 member 5	Homo sapiens	62-65
15240449-8	2004	Between the interfaces in the ScyTx-rsk2 complex, strong electrostatic interaction and hydrogen bonds exist between Arg(13) of ScyTx and Gly-Tyr-Gly-Asp sequential residues located in the four symmetrical chains of the pore region.	Aspartic Acid	149-152	ribosomal protein S6 kinase A3	Homo sapiens	36-40
15196952-5	2004	Here, we show that expression of ezrin mutants in which the COOH-terminal threonine T567 was replaced by an aspartate (to mimic a phosphorylated residue; T567D) or by an alanine (to avoid phosphorylation; T567A) interferes with E-cadherin function and disrupts the first morphogenetic events of development: compaction and cavitation.	Aspartic Acid	108-117	ezrin	Mus musculus	33-38
15107472-7	2004	The shifts in potency produced by NR2D(T692A) containing receptors when activated by other glutamate-site agonists such as aspartate or NMDA were 30- to 60-fold compared to wild-type.	Aspartic Acid	123-132	glutamate receptor, ionotropic, N-methyl D-aspartate 2D L homeolog	Xenopus laevis	34-38
15194785-7	2004	Mutational analyses of the p51 YMDD aspartates indicated that they play an important structural role in p51 folding and subunit interactions that are required for the formation of an active RT heterodimer within infected cells.	Aspartic Acid	36-46	tumor protein p63	Homo sapiens	27-30
15194785-7	2004	Mutational analyses of the p51 YMDD aspartates indicated that they play an important structural role in p51 folding and subunit interactions that are required for the formation of an active RT heterodimer within infected cells.	Aspartic Acid	36-46	tumor protein p63	Homo sapiens	104-107
15219196-7	2004	Interestingly, three different effects were found with the recombinant FXa Gla-mutants for AT-heparin inhibition: (i) Gla--&gt;Asp 14 and 29 were enhanced without calcium; (ii) Gla--&gt;Asp 16 and 26 were not enhanced by calcium; and (iii) Gla--&gt;Asp 19 was essentially the same as wild-type recombinant FXa.	Aspartic Acid	186-189	coagulation factor X	Homo sapiens	71-74
15219196-7	2004	Interestingly, three different effects were found with the recombinant FXa Gla-mutants for AT-heparin inhibition: (i) Gla--&gt;Asp 14 and 29 were enhanced without calcium; (ii) Gla--&gt;Asp 16 and 26 were not enhanced by calcium; and (iii) Gla--&gt;Asp 19 was essentially the same as wild-type recombinant FXa.	Aspartic Acid	186-189	coagulation factor X	Homo sapiens	71-74
15146057-4	2004	Here, we identify three WD (Trp-Asp)-repeat nucleoporins as new members of this complex, two of which, Nup37 and Nup43, are specific to higher eukaryotes.	Aspartic Acid	32-35	nucleoporin 37	Homo sapiens	103-108
15146057-4	2004	Here, we identify three WD (Trp-Asp)-repeat nucleoporins as new members of this complex, two of which, Nup37 and Nup43, are specific to higher eukaryotes.	Aspartic Acid	32-35	nucleoporin 43	Homo sapiens	113-118
15326283-1	2004	An experimentally determined pK(a) change of +2.50 units has been reported for the B13 Glu residue in a dimeric B9 Ser --&gt; Asp insulin mutant relative to the native dimer.	Aspartic Acid	126-129	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	83-86
15169949-8	2004	Demonstration of the influence of conserved aspartate 302 appears to represent the first documentation of the functional importance of a residue in the MDD catalytic site and affords insight into phosphotransferase reactions catalyzed by a variety of enzymes in the galactokinase, homoserine kinase, mevalonate kinase, phosphom-evalonate kinase (GHMP kinase) family.	Aspartic Acid	44-53	galactokinase 1	Homo sapiens	266-344
15170212-2	2004	Here we demonstrate that the unique Rac2 localization and functions in neutrophils are regulated by two separate C-terminal motifs, the hypervariable domain and aspartic acid 150, one of which has not previously been linked to the function of Rho GTPases.	Aspartic Acid	161-174	Rac family small GTPase 2	Homo sapiens	36-40
15326283-1	2004	An experimentally determined pK(a) change of +2.50 units has been reported for the B13 Glu residue in a dimeric B9 Ser --&gt; Asp insulin mutant relative to the native dimer.	Aspartic Acid	126-129	insulin	Homo sapiens	130-137
15209503-6	2004	In the present work, a library of 21 TM3/4 constructs was prepared, where Asp residues were placed individually at TM4 positions 221-241.	Aspartic Acid	74-77	tropomyosin 3	Homo sapiens	37-40
15012629-2	2004	In the present study, we show by protein-protein cross-linking that Scp160p is in close proximity to translation elongation factor 1A and the WD40 (Trp-Asp 40)-repeat containing protein Asc1p at ribosomes.	Aspartic Acid	152-155	solute carrier family 7 member 10	Homo sapiens	186-191
15084588-1	2004	A new recombinant, human anti-sickling beta-globin polypeptide designated beta(AS3) (betaGly(16) --&gt; Asp/betaGlu(22) --&gt; Ala/betaThr(87) --&gt; Gln) was designed to increase affinity for alpha-globin.	Aspartic Acid	104-107	PDS5 cohesin associated factor B	Homo sapiens	74-82
15087450-4	2004	In this report, we demonstrate that human MLH1 is specifically cleaved by caspase-3 at Asp(418) in vitro.	Aspartic Acid	87-90	mutL homolog 1	Homo sapiens	42-46
15087450-4	2004	In this report, we demonstrate that human MLH1 is specifically cleaved by caspase-3 at Asp(418) in vitro.	Aspartic Acid	87-90	caspase 3	Homo sapiens	74-83
15196016-9	2004	In the heterodimer, interactions with a loop region connecting Rnr4 helices alphaA and alpha3 stabilize this Rnr2 helix, which donates iron ligand Asp 145.	Aspartic Acid	147-150	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	63-67
15196016-9	2004	In the heterodimer, interactions with a loop region connecting Rnr4 helices alphaA and alpha3 stabilize this Rnr2 helix, which donates iron ligand Asp 145.	Aspartic Acid	147-150	ribonucleotide-diphosphate reductase subunit RNR2	Saccharomyces cerevisiae S288C	109-113
15122313-3	2004	Mcl-1 was efficiently cleaved by caspases at evolutionarily conserved aspartic acid residues in vitro, and during cisplatin-induced apoptosis in B-lymphoma cell lines and spontaneous apoptosis of primary malignant B-cells.	Aspartic Acid	70-83	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	0-5
15030318-2	2004	In this study we have identified Ser-304 (Phe301-Asp-His-Ser304-Pro-Asn-Lys307) as a major TCPTP phosphory-lation site and demonstrate that TC45, but not TC48, is phosphorylated on this site in vivo.	Aspartic Acid	49-52	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	91-96
15100231-8	2004	Electrophysiological studies using 80K-H mutants showed that three domains of 80K-H (the two EF-hand structures, the highly acidic glutamic stretch, and the His-Asp-Glu-Leu sequence) are critical determinants for TRPV5 activity.	Aspartic Acid	161-164	transient receptor potential cation channel subfamily V member 5	Homo sapiens	213-218
15054102-1	2004	Aralar1 and citrin were identified as calcium binding aspartate/glutamate carriers (AGC) in mitochondria.	Aspartic Acid	54-63	solute carrier family 25 member 13	Homo sapiens	12-18
15073390-9	2004	CONCLUSIONS: The eNOS Glu298--&gt;Asp polymorphism may be related to early atherogenesis.	Aspartic Acid	34-37	nitric oxide synthase 3	Homo sapiens	17-21
15126881-1	2004	PURPOSE: An amino acid changing polymorphism in the UDP-glucuronosyltransferase (UGT) 2B15 gene has been described at codon 85 (aspartate&gt;tyrosine).	Aspartic Acid	128-137	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	52-90
15135308-1	2004	We have expressed the human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 stably in HEK293 cells and characterized the transporters pharmacologically in a conventional [(3) H]-d-aspartate uptake assay and in a fluorescence-based membrane potential assay, the FLIPR Membrane Potential (FMP) assay.	Aspartic Acid	190-199	solute carrier family 1 member 3	Homo sapiens	63-68
15135308-1	2004	We have expressed the human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 stably in HEK293 cells and characterized the transporters pharmacologically in a conventional [(3) H]-d-aspartate uptake assay and in a fluorescence-based membrane potential assay, the FLIPR Membrane Potential (FMP) assay.	Aspartic Acid	190-199	solute carrier family 1 member 2	Homo sapiens	70-75
15135308-1	2004	We have expressed the human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 stably in HEK293 cells and characterized the transporters pharmacologically in a conventional [(3) H]-d-aspartate uptake assay and in a fluorescence-based membrane potential assay, the FLIPR Membrane Potential (FMP) assay.	Aspartic Acid	190-199	solute carrier family 1 member 1	Homo sapiens	80-85
15189451-5	2004	The caspase-mediated cleavage of LIMK1 occurs at Asp-240, a site at the N-terminal side of the protein kinase domain, which leads to the production of an N-terminally truncated, constitutively active LIMK1 fragment.	Aspartic Acid	49-52	LIM domain kinase 1	Homo sapiens	33-38
15189451-5	2004	The caspase-mediated cleavage of LIMK1 occurs at Asp-240, a site at the N-terminal side of the protein kinase domain, which leads to the production of an N-terminally truncated, constitutively active LIMK1 fragment.	Aspartic Acid	49-52	LIM domain kinase 1	Homo sapiens	200-205
15171717-5	2004	Bound (125)I-hIGFBP-2 was reversibly displaced by IGFBP-2, IGFBP-1 and RGD-(Gly-Arg-Asp)-containing peptides, but not by IGFBP-3, -4, -5, -6 and RGE-(Gly-Arg-Glu)-containing peptides.	Aspartic Acid	84-87	insulin like growth factor binding protein 2	Homo sapiens	13-21
15171717-5	2004	Bound (125)I-hIGFBP-2 was reversibly displaced by IGFBP-2, IGFBP-1 and RGD-(Gly-Arg-Asp)-containing peptides, but not by IGFBP-3, -4, -5, -6 and RGE-(Gly-Arg-Glu)-containing peptides.	Aspartic Acid	84-87	insulin like growth factor binding protein 2	Homo sapiens	14-21
15075374-3	2004	Cleavage of HDAC4 occurs at Asp 289 and disjoins the carboxy-terminal fragment, localized into the cytoplasm, from the amino-terminal fragment, which accumulates into the nucleus.	Aspartic Acid	28-31	histone deacetylase 4	Mus musculus	12-17
15177960-14	2004	Twelve members of the family were found to have a heterozygous single mutation in the TGFBI gene leading to a predicted amino acid substitution of aspartic acid for alanine (A546D).	Aspartic Acid	147-160	transforming growth factor beta induced	Homo sapiens	86-91
15147190-3	2004	This derivative is based on the sequence of the first 30 amino acid residues of Abeta with asparagyl/glutamyl-4-aminobutane residues (N-4ab/Q-4ab) substituted at unique Asp and Glu positions and with Gd-DTPA-aminohexanoic acid covalently attached at the N-terminal Asp.	Aspartic Acid	169-172	amyloid beta (A4) precursor protein	Mus musculus	80-85
15147190-3	2004	This derivative is based on the sequence of the first 30 amino acid residues of Abeta with asparagyl/glutamyl-4-aminobutane residues (N-4ab/Q-4ab) substituted at unique Asp and Glu positions and with Gd-DTPA-aminohexanoic acid covalently attached at the N-terminal Asp.	Aspartic Acid	265-268	amyloid beta (A4) precursor protein	Mus musculus	80-85
15147190-5	2004	This diamine- and gadolinium-substituted derivative of Abeta is shown to have enhanced in vitro binding to Alzheimer"s disease (AD) amyloid plaques and increased in vivo permeability at the blood-brain barrier because of the unique Asp/Glu substitutions.	Aspartic Acid	232-235	amyloid beta (A4) precursor protein	Mus musculus	55-60
15096612-6	2004	Unlike GluRS, the YadB protein was able to activate glutamate in presence of ATP in a tRNA-independent fashion and to transfer glutamate onto tRNA(Asp).	Aspartic Acid	147-150	hypothetical protein	Escherichia coli	18-22
15105544-3	2004	Altering the critical P1-aspartate in the CrmA reactive centre loop to alanine resulted in a virus (CPV-CrmA-D303A) that resembled CPV deleted for CrmA (CPVDeltaCrmA : : lacZ); on CAMs it produced white, inflammatory pocks with activated caspase-3 and reduced virus yields, suggesting that CrmA activities are mediated via proteinase inhibition.	Aspartic Acid	25-34	CrmA or CPXV207 protein	Cowpox virus	42-46
15084314-5	2004	Similar to its action on AP sites in ds DNA, catalysis of endonucleolytic cleavage of ss DNA by APE1 is Mg(2+) dependent, DNA N-glycosylase independent, and requires an active site aspartate.	Aspartic Acid	181-190	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	96-100
15037553-4	2004	Two enzymes are potentially able to release Ac-SDKP from thymosin-beta4: prolyl oligopeptidase (POP) and endoproteinase asp-N.	Aspartic Acid	120-123	thymosin beta 4, X-linked	Rattus norvegicus	57-71
15051429-1	2004	The effect of aspartic acid on the adsorption of Pb(II), Cu(II), Zn(II), Co(II), and Mn(II) on kaolinite at 25 degrees C in the presence of 5 mM KNO3 was investigated by means of potentiometric titrations and adsorption measurements over a range of pH and concentration.	Aspartic Acid	14-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
14751929-1	2004	Ahi-1/AHI-1 (Abelson helper integration site-1) encodes a family of protein isoforms containing one Src homology 3 (SH3) domain and multiple tryptophan-aspartic acid 40 (WD40)-repeat domains.	Aspartic Acid	152-165	Abelson helper integration site 1	Homo sapiens	0-5
14751929-1	2004	Ahi-1/AHI-1 (Abelson helper integration site-1) encodes a family of protein isoforms containing one Src homology 3 (SH3) domain and multiple tryptophan-aspartic acid 40 (WD40)-repeat domains.	Aspartic Acid	152-165	Abelson helper integration site 1	Homo sapiens	6-11
15128940-0	2004	An invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene.	Aspartic Acid	13-26	HhH-GPD base excision DNA repair family protein	Arabidopsis thaliana	60-67
15128940-0	2004	An invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene.	Aspartic Acid	13-26	SET domain-containing protein	Arabidopsis thaliana	129-134
15128940-7	2004	We mutated the invariant aspartic acid at position 1304 in DME to asparagine (D1304N) to determine whether the catalytic activity of the DNA glycosylase domain is required for DME function in vivo.	Aspartic Acid	25-38	HhH-GPD base excision DNA repair family protein	Arabidopsis thaliana	59-62
15128940-11	2004	These results show that the conserved aspartic acid residue is necessary for DME to function in vivo and suggest that an active DNA glycosylase domain, normally associated with DNA repair, promotes gene transcription that is essential for gene imprinting.	Aspartic Acid	38-51	HhH-GPD base excision DNA repair family protein	Arabidopsis thaliana	77-80
15140628-0	2004	The N-terminal of icatibant and bradykinin interact with the same Asp residues in the human B2 receptor.	Aspartic Acid	66-69	kininogen 1	Homo sapiens	32-42
15140628-0	2004	The N-terminal of icatibant and bradykinin interact with the same Asp residues in the human B2 receptor.	Aspartic Acid	66-69	bradykinin receptor B2	Homo sapiens	92-103
15182057-0	2004	Two cases of compound heterozygosity for Hb Hekinan [alpha27(B8)Glu--&gt;Asp (alpha1)] and alpha-thalassemia in Thailand.	Aspartic Acid	73-76	adrenoceptor alpha 1D	Homo sapiens	78-84
15182057-1	2004	Two unrelated cases of compound heterozygosity for Hb Hekinan [alpha27(B8)Glu--&gt;Asp (alpha1) and alpha-thalassemia have been found in Thailand.	Aspartic Acid	83-86	adrenoceptor alpha 1D	Homo sapiens	88-94
15051429-3	2004	Aspartic acid slightly enhanced the adsorption of Pb(II), Zn(II), and Co(II) at low pH, but inhibited the adsorption of all the metal ions at higher pH.	Aspartic Acid	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
15051429-7	2004	Cu(II) and Co(II) form complexes with aspartic acid more strongly than the other metals.	Aspartic Acid	38-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
15051429-8	2004	As these complexes do not adsorb, Cu(II) and Co(II) suffer greater suppression from aspartic acid than the other metals.	Aspartic Acid	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
15140190-6	2004	Site-directed mutagenesis experiments eliminating three, six or nine potential caspase cleavage sites in the protein suggest redundancy in the site(s) at which cleavage can occur, as previously described for other disease proteins; but also map a major cleavage event to a cluster of aspartate residues within the ubiquitin-binding domain of ataxin-3 near the polyglutamine tract.	Aspartic Acid	284-293	caspase 1	Homo sapiens	79-86
15079862-4	2004	Unlike other synaptotagmins, SytIV has an evolutionarily conserved substitution of an aspartate to a serine in the Ca(2+) coordination site of its C2A domain, preventing SytIV from binding anionic lipids in a Ca(2+)-dependent fashion.	Aspartic Acid	86-95	synaptotagmin 4	Rattus norvegicus	29-34
15079862-4	2004	Unlike other synaptotagmins, SytIV has an evolutionarily conserved substitution of an aspartate to a serine in the Ca(2+) coordination site of its C2A domain, preventing SytIV from binding anionic lipids in a Ca(2+)-dependent fashion.	Aspartic Acid	86-95	synaptotagmin 4	Rattus norvegicus	170-175
15079862-7	2004	However, conversion of the unique serine in SytIV to an aspartate eliminated this inhibitory activity.	Aspartic Acid	56-65	synaptotagmin 4	Rattus norvegicus	44-49
14966111-4	2004	To investigate the function of one of these residues in neuronal NOS (nNOS), we generated and characterized mutants that had Val, Glu, or Asn substituted for the conserved Asp-1393.	Aspartic Acid	172-175	nitric oxide synthase 1	Homo sapiens	70-74
15159136-6	2004	Aspartate level significantly increased in the brain stem (BS) and hippocampus (HI), while it decreased in the diencephalon (DE) of IL-6(-/-) mice.	Aspartic Acid	0-9	interleukin 6	Mus musculus	132-136
14769788-8	2004	However, two highly phosphorylated fragments representing the N- and C-terminal portions of DMP1 have been identified, apparently arising from proteolytic cleavage of four X-Asp bonds.	Aspartic Acid	174-177	dentin matrix protein 1	Mus musculus	92-96
14966111-11	2004	1) The presence and positioning of the Asp-1393 carboxylate side chain are critical to enable NADPH-dependent reduction of the nNOS flavoprotein.	Aspartic Acid	39-42	nitric oxide synthase 1	Homo sapiens	127-131
15080651-0	2004	Monohydroxamates of aspartic acid and glutamic acid exhibit antioxidant and angiotensin converting enzyme inhibitory activities.	Aspartic Acid	20-33	angiotensin I converting enzyme	Homo sapiens	76-105
14749323-6	2004	We showed that the putative glycosylation site Asp-39 in mOAT1 was not glycosylated but the corresponding site (Asp-39) in hOAT1 was glycosylated.	Aspartic Acid	47-50	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	57-62
14757757-6	2004	Analysis of homozygous mutant mice (termed ACE 7/7) showed normal plasma levels of angiotensin II but an elevation of plasma and urine N-acetyl-Ser-Asp-Lys-Pro, a peptide suggested to inhibit bone marrow maturation.	Aspartic Acid	148-151	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	43-46
15054114-7	2004	The caspase cleavage site in occludin was mapped C-terminally to Asp(320) within the C-terminal cytoplasmic domain.	Aspartic Acid	65-68	occludin	Homo sapiens	29-37
14749323-6	2004	We showed that the putative glycosylation site Asp-39 in mOAT1 was not glycosylated but the corresponding site (Asp-39) in hOAT1 was glycosylated.	Aspartic Acid	47-50	solute carrier family 22 member 6	Homo sapiens	123-128
14749323-6	2004	We showed that the putative glycosylation site Asp-39 in mOAT1 was not glycosylated but the corresponding site (Asp-39) in hOAT1 was glycosylated.	Aspartic Acid	112-115	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	57-62
14749323-6	2004	We showed that the putative glycosylation site Asp-39 in mOAT1 was not glycosylated but the corresponding site (Asp-39) in hOAT1 was glycosylated.	Aspartic Acid	112-115	solute carrier family 22 member 6	Homo sapiens	123-128
14749323-7	2004	Disrupting Asp-39 resulted in a complete loss of transport activity in both mOAT1 and hOAT1 without affecting their cell surface expression, suggesting that the loss of function is not because of deglycosylation of Asp-39 per se but rather is likely because of the change of this important amino acid critically involved in the substrate binding.	Aspartic Acid	11-14	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	76-81
14749323-7	2004	Disrupting Asp-39 resulted in a complete loss of transport activity in both mOAT1 and hOAT1 without affecting their cell surface expression, suggesting that the loss of function is not because of deglycosylation of Asp-39 per se but rather is likely because of the change of this important amino acid critically involved in the substrate binding.	Aspartic Acid	11-14	solute carrier family 22 member 6	Homo sapiens	86-91
14749323-10	2004	In summary, we provided the evidence that 1) Asp-39 is crucially involved in substrate recognition of OAT1, 2) glycosylation at individual sites is not required for OAT1 function, and 3) glycosylation plays an important role in the targeting of OAT1 onto the plasma membrane.	Aspartic Acid	45-48	solute carrier family 22 member 6	Homo sapiens	102-109
14749323-10	2004	In summary, we provided the evidence that 1) Asp-39 is crucially involved in substrate recognition of OAT1, 2) glycosylation at individual sites is not required for OAT1 function, and 3) glycosylation plays an important role in the targeting of OAT1 onto the plasma membrane.	Aspartic Acid	45-48	solute carrier family 22 member 6	Homo sapiens	102-106
15005845-10	2004	Substitution of K29 by aspartate equivalently increased CaR sensitivity, whereas conservative substitution by arginine did not.	Aspartic Acid	23-32	calcium sensing receptor	Homo sapiens	56-59
14715079-9	2004	Previous work in vitro suggested that only Asp-351 was required for interaction with Smad2 [Wu, Fairman, Penry and Shi (2001) J. Biol.	Aspartic Acid	43-46	SMAD family member 2	Homo sapiens	85-90
15042566-5	2004	In DNA from the breast and liver tumors the authors showed the same missense mutation in codon 245 (GGC--&gt;GAC; Gly--&gt;Asp) of exon 7 of p53.	Aspartic Acid	123-126	tumor protein p53	Homo sapiens	141-144
15056512-0	2004	Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.	Aspartic Acid	45-54	solute carrier family 25 member 12	Homo sapiens	73-81
15060622-0	2004	A study of the relationships of interactions between Asp-201, Na+ or K+, and galactosyl C6 hydroxyl and their effects on binding and reactivity of beta-galactosidase.	Aspartic Acid	53-56	galactosidase beta 1	Homo sapiens	147-165
15060622-1	2004	The interactions between Na+ (and K+) and Asp-201 of beta-galactosidase were studied.	Aspartic Acid	42-45	galactosidase beta 1	Homo sapiens	53-71
15060622-17	2004	D201F-beta-galactosidase, with a very bulky hydrophobic side chain in place of Asp, essentially obliterated all binding and catalysis.	Aspartic Acid	79-82	galactosidase beta 1	Homo sapiens	6-24
15010145-8	2004	The rate constants for Asp cleavage were not first-order with respect to hydronium ion concentration and cleavage at Asp-21 was slower than cleavage at Asp-9 and Asp-15 over the studied pH range.	Aspartic Acid	23-26	beta-secretase 2	Homo sapiens	117-123
15050970-1	2004	Citrin is a mitochondrial aspartate glutamate carrier primarily expressed in the liver, heart, and kidney.	Aspartic Acid	26-35	solute carrier family 25 member 13	Homo sapiens	0-6
15050970-3	2004	In this report, we describe the frequency of SLC25A13 mutations, the roles of citrin as a member of the urea cycle and as a member of the malate-aspartate shuttle, the relationship between its functions and symptoms of citrin deficiency, and therapeutic issues.	Aspartic Acid	145-154	solute carrier family 25 member 13	Homo sapiens	78-84
15037072-2	2004	Protein cleavage sites for the Ricinus CysEP were determined with fluorogenic peptides (Abz-Xaa-Arg-/-Gln-Gln-Tyr(NO2)-Asp).	Aspartic Acid	119-122	vignain	Ricinus communis	39-44
15073296-4	2004	Chemical stability analysis and site-directed mutagenesis implicated the highly conserved residues His(395) and Asp(54) as the sites of phosphorylation in DevS and DevR, respectively.	Aspartic Acid	112-115	two component transcriptional regulator DevR	Mycobacterium tuberculosis H37Rv	164-168
15056474-2	2004	Two aspartates in presenilins (PS) are required for gamma-secretase activity (D257 and D385 of PS1), suggesting that PS may be part of this protease.	Aspartic Acid	4-14	taste 2 receptor member 62 pseudogene	Homo sapiens	95-98
15078326-7	2004	Site-directed mutagenesis of these residues indicates that RAR1 independence requires the presence of an aspartate at position 721, as mutation of this residue to a structurally similar, but uncharged, asparagine did not alter RAR1 dependence.	Aspartic Acid	105-114	zinc-binding protein	Hordeum vulgare	59-63
15044735-7	2004	This is well illustrated by AST, in which Asp 150 and Glu 221B, despite some distance from the S1 binding site, lower the electrostatic potential of the S1 site and thus enhance substrate binding.	Aspartic Acid	42-45	solute carrier family 17 member 5	Homo sapiens	28-31
14764598-10	2004	In the MUC16 SEA domains, the conserved surface residues, Asn-10, Thr-12, Arg-63, Asp-75, Asp-112, Ser-115, and Phe-117, are clustered on the beta sheet surface, which may be functionally important.	Aspartic Acid	82-85	mucin 16	Mus musculus	7-12
14764598-10	2004	In the MUC16 SEA domains, the conserved surface residues, Asn-10, Thr-12, Arg-63, Asp-75, Asp-112, Ser-115, and Phe-117, are clustered on the beta sheet surface, which may be functionally important.	Aspartic Acid	90-93	mucin 16	Mus musculus	7-12
14702345-2	2004	Here, site-directed Arg to Asp mutations in Crp4 have been shown to attenuate or eliminate microbicidal activity against all of the bacterial species tested regardless of the Arg residue position.	Aspartic Acid	27-30	defensin, alpha, 20	Mus musculus	44-48
14656218-0	2004	Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif.	Aspartic Acid	102-111	G protein signaling modulator 3	Homo sapiens	86-89
14999100-4	2004	Here, we demonstrate that a single APOBEC3G residue, which is an aspartic acid in human APOBEC3G and a lysine in agm APOBEC3G, controls the ability of the HIV-1 Vif protein to bind and inactivate these host defense factors.	Aspartic Acid	65-78	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	35-43
14999100-4	2004	Here, we demonstrate that a single APOBEC3G residue, which is an aspartic acid in human APOBEC3G and a lysine in agm APOBEC3G, controls the ability of the HIV-1 Vif protein to bind and inactivate these host defense factors.	Aspartic Acid	65-78	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	88-96
14999100-4	2004	Here, we demonstrate that a single APOBEC3G residue, which is an aspartic acid in human APOBEC3G and a lysine in agm APOBEC3G, controls the ability of the HIV-1 Vif protein to bind and inactivate these host defense factors.	Aspartic Acid	65-78	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	88-96
15005607-3	2004	The structure of the peptide consisted of a well-defined beta-turn between Gly(13) and Asp(16) of gastrin.	Aspartic Acid	87-90	gastrin	Homo sapiens	98-105
14978285-6	2004	Among residues constituting the interface, Phe-34, Ser-36A, Leu-65, Tyr-76, Arg-77A, Ile-82, and Lys-110 of thrombin and the A alpha chain Trp-33, Phe-35, Asp-38, Glu-39, the B beta chain Ala-68 and Asp-69, and the gamma chain Asp-27 and Ser-30 of E(ht) form a net of polar contacts surrounding a well defined hydrophobic interior.	Aspartic Acid	155-158	coagulation factor II, thrombin	Homo sapiens	108-116
14978285-6	2004	Among residues constituting the interface, Phe-34, Ser-36A, Leu-65, Tyr-76, Arg-77A, Ile-82, and Lys-110 of thrombin and the A alpha chain Trp-33, Phe-35, Asp-38, Glu-39, the B beta chain Ala-68 and Asp-69, and the gamma chain Asp-27 and Ser-30 of E(ht) form a net of polar contacts surrounding a well defined hydrophobic interior.	Aspartic Acid	199-202	coagulation factor II, thrombin	Homo sapiens	108-116
14978285-6	2004	Among residues constituting the interface, Phe-34, Ser-36A, Leu-65, Tyr-76, Arg-77A, Ile-82, and Lys-110 of thrombin and the A alpha chain Trp-33, Phe-35, Asp-38, Glu-39, the B beta chain Ala-68 and Asp-69, and the gamma chain Asp-27 and Ser-30 of E(ht) form a net of polar contacts surrounding a well defined hydrophobic interior.	Aspartic Acid	199-202	coagulation factor II, thrombin	Homo sapiens	108-116
15073296-6	2004	DevR-DevS was thus established as a typical two-component regulatory system based on His-to-Asp phosphoryl transfer.	Aspartic Acid	92-95	two component transcriptional regulator DevR	Mycobacterium tuberculosis H37Rv	0-4
14996540-3	2004	One of these mutations is a non-conservative change of alanine to aspartate in the third transmembrane domain of the alpha1 subunit.	Aspartic Acid	66-75	adrenoceptor alpha 1D	Homo sapiens	117-123
15035637-6	2004	Furthermore, Ala substitutions of Asn(3), Asp(4), and Asp(7) show that the side chains of these residues are important for high-affinity binding of CCL-19 to CCR-7.	Aspartic Acid	42-45	C-C motif chemokine ligand 19	Homo sapiens	148-154
15035637-6	2004	Furthermore, Ala substitutions of Asn(3), Asp(4), and Asp(7) show that the side chains of these residues are important for high-affinity binding of CCL-19 to CCR-7.	Aspartic Acid	42-45	C-C motif chemokine receptor 7	Homo sapiens	158-163
14722087-1	2004	Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids that contains a Gly-Arg-Gly-Asp-Ser sequence.	Aspartic Acid	139-142	secreted phosphoprotein 1	Mus musculus	0-11
14722087-1	2004	Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids that contains a Gly-Arg-Gly-Asp-Ser sequence.	Aspartic Acid	139-142	secreted phosphoprotein 1	Mus musculus	13-16
15016421-0	2004	Poorer cognitive performance in humans with mild cognitive impairment carrying the T variant of the Glu/Asp NOS3 polymorphism.	Aspartic Acid	104-107	nitric oxide synthase 3	Homo sapiens	108-112
15016421-3	2004	We studied the distribution of genotype and allele frequencies of the NOS3 Glu/Asp polymorphism in a sample of 62 MCI subjects and 136 controls.	Aspartic Acid	79-82	nitric oxide synthase 3	Homo sapiens	70-74
14978281-6	2004	Replacement of Asp-128 in human APOBEC3G with the Lys-128 of AGM APOBEC3G caused the enzyme to switch its interaction, becoming sensitive to SIV(AGM) Vif and resistant to HIV-1 Vif.	Aspartic Acid	15-18	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	32-40
14978281-6	2004	Replacement of Asp-128 in human APOBEC3G with the Lys-128 of AGM APOBEC3G caused the enzyme to switch its interaction, becoming sensitive to SIV(AGM) Vif and resistant to HIV-1 Vif.	Aspartic Acid	15-18	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	65-73
14978281-7	2004	Conversely, the reciprocal Lys to Asp switch in AGM APOBEC3G reversed its specificity for Vif.	Aspartic Acid	34-37	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	52-60
14679197-0	2004	Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin.	Aspartic Acid	8-11	coagulation factor II, thrombin	Homo sapiens	89-97
14679197-1	2004	Residue Asp-189 plays an important dual role in thrombin: it defines the primary specificity for Arg side chains and participates indirectly in the coordination of Na(+).	Aspartic Acid	8-11	coagulation factor II, thrombin	Homo sapiens	48-56
14679197-7	2004	The observation that a single amino acid substitution can alter the monovalent cation specificity of thrombin from Na(+) (Asp-189) to Li(+) (Ser-189) or Rb(+) (Glu-189) is unprecedented in the realm of monovalent cation-activated enzymes.	Aspartic Acid	122-125	coagulation factor II, thrombin	Homo sapiens	101-109
15003013-1	2004	In this study, specific interactions between immobilized RGDS (Arg-Gly-Asp-Ser) cell adhesion peptides and cell integrin receptors located on cell membranes are controlled in vitro using stimuli-responsive polymer surface chemistry.	Aspartic Acid	71-74	ral guanine nucleotide dissociation stimulator	Homo sapiens	57-61
15134829-3	2004	The extent and duration of IR endocytosis were markedly increased in response to the H2-analogue and [Asp(B10)]HI compared to wild-type HI, but similar to HI after [Glu(A13),Glu(B10)]HI administration.	Aspartic Acid	102-105	insulin receptor	Rattus norvegicus	27-29
15041166-2	2004	Additionally, HLA-DRB1 alleles encoding an aspartic acid at position 70 (D70+ ) have been associated with protection against the development of RA.	Aspartic Acid	43-56	major histocompatibility complex, class II, DR beta 1	Homo sapiens	14-22
15013973-8	2004	The results demonstrate strong IgE binding with Asp f 4 and two truncated mutants, Asp f 4(1-234) (amino acids [aa] 1 to 234) and Asp f 4(1-241) (aa 1 to 241), while another mutant, Asp f 4(1-196) (aa 1 to 196), showed reactivity with fewer patients.	Aspartic Acid	48-51	immunoglobulin heavy constant epsilon	Homo sapiens	31-34
15010069-7	2004	Two tumours with no detectable c-KIT mutations demonstrated PDGFRA Asp--&gt;Glu(842) amino acid substitutions.	Aspartic Acid	67-70	platelet derived growth factor receptor alpha	Homo sapiens	60-66
14978247-6	2004	Our data show that the affinity of Lqh-3 and LqhalphaIT to sodium channels is markedly determined by an aspartate residue (Asp1428 in rNaV1.4); when mutated to glutamate, as is present in NaV1.1-1.3 channels, Lqh-3-channel interactions are abolished.	Aspartic Acid	104-113	neuron navigator 1	Homo sapiens	135-139
14970260-2	2004	Wild-type type-3 ryanodine receptor and mutant type-3 ryanodine receptor in which the critical valine at position 2322 in the central 12 kDa FK506-binding protein binding site was substituted by aspartate, were stably expressed in human embryonic kidney cells.	Aspartic Acid	195-204	ryanodine receptor 3	Homo sapiens	47-72
15832508-5	2004	For all nucleoside parent drugs, BPHL preferred the hydrophobic amino acids valine, phenylalanine, and proline over the charged amino acids lysine and aspartic acid.	Aspartic Acid	151-164	biphenyl hydrolase like	Homo sapiens	33-37
14729472-9	2004	Furthermore, we show that in apoptotic cells, POM121 is specifically cleaved at aspartate-531 in its large C-terminal portion by a caspase-3-dependent mechanism.	Aspartic Acid	80-89	POM121 transmembrane nucleoporin	Homo sapiens	46-52
15171648-5	2004	RESULTS: ASP markedly enhanced the phagocytic activity, ACP and supernatant NO, TNF-alpha of Kupffer cells both in vitro and in vivo .	Aspartic Acid	9-12	tumor necrosis factor	Rattus norvegicus	80-89
14599290-8	2004	Like caspase-3, caspase-2 cleaves alphaII-spectrin in vitro at residue Asp-1185.	Aspartic Acid	71-74	caspase 3	Homo sapiens	5-14
14599290-8	2004	Like caspase-3, caspase-2 cleaves alphaII-spectrin in vitro at residue Asp-1185.	Aspartic Acid	71-74	caspase 2	Homo sapiens	16-25
14599290-8	2004	Like caspase-3, caspase-2 cleaves alphaII-spectrin in vitro at residue Asp-1185.	Aspartic Acid	71-74	spectrin alpha, non-erythrocytic 1	Homo sapiens	34-50
14599290-10	2004	We also demonstrated that the executioner caspase-7 but not caspase-6 cleaves spectrin at residue Asp-1185 in vitro.	Aspartic Acid	98-101	caspase 7	Homo sapiens	42-51
14989719-3	2004	B*0732 differs from HLA-B*0708 by one nucleotidic change at position 412 (from G to A) in exon 3, leading to an amino acidic substitution from Asp (GAC) to Asn (AAC) at codon 114.	Aspartic Acid	143-146	major histocompatibility complex, class I, B	Homo sapiens	20-25
14729472-9	2004	Furthermore, we show that in apoptotic cells, POM121 is specifically cleaved at aspartate-531 in its large C-terminal portion by a caspase-3-dependent mechanism.	Aspartic Acid	80-89	caspase 3	Homo sapiens	131-140
14660644-0	2004	Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding.	Aspartic Acid	0-9	solute carrier family 6 member 3	Homo sapiens	21-41
14977832-0	2004	Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples.	Aspartic Acid	31-34	fms related receptor tyrosine kinase 3	Homo sapiens	26-30
14977832-1	2004	PURPOSE: We analyzed Asp(835) mutations of FLT3 on paired marrow samples at diagnosis and relapse from 120 adult patients with de novo acute myeloid leukemia (AML) to determine the role of FLT3 Asp(835) mutation in the relapse of AML.	Aspartic Acid	21-24	fms related receptor tyrosine kinase 3	Homo sapiens	43-47
14977832-2	2004	EXPERIMENTAL DESIGN: Asp(835) mutation was analyzed by DNA PCR amplification of exon 20 of FLT3 gene followed by EcoRV digestion.	Aspartic Acid	21-24	fms related receptor tyrosine kinase 3	Homo sapiens	91-95
14977832-10	2004	CONCLUSIONS: The present study showed that patients with AML had heterogeneous patterns of FLT3 Asp(835) mutations, either acquisition or loss of the mutations at relapse.	Aspartic Acid	96-99	fms related receptor tyrosine kinase 3	Homo sapiens	91-95
14746454-3	2004	The bacterial PI-PLC has no sequence homology with known glucose-6-phosphatase enzymes, which need His, Arg, and negatively charged residues (Asp or Glu) at the active site.	Aspartic Acid	142-145	phospholipase C beta 1	Homo sapiens	14-20
14756555-8	2004	The conserved Asp-201, expected for an aminotransferase fold, is located near the PLP nitrogen, but Asp-132 is also strictly conserved and at a similar distance from the pyridinium nitrogen.	Aspartic Acid	14-17	pyridoxal phosphatase	Homo sapiens	82-85
14756555-9	2004	Mutagenesis of both conserved aspartic acids shows that both contribute equally to PLP binding, but Asp-201 has a greater role in catalysis.	Aspartic Acid	30-44	pyridoxal phosphatase	Homo sapiens	83-86
14756561-5	2004	Mutating the two putative Akt phosphorylation sites to Ala (nonsubstrate) in these peptides increases the inhibitory potency while mutating the sites to aspartic acid (phosphorylation mimetic) reduces the potency.	Aspartic Acid	153-166	AKT serine/threonine kinase 1	Homo sapiens	26-29
14746454-3	2004	The bacterial PI-PLC has no sequence homology with known glucose-6-phosphatase enzymes, which need His, Arg, and negatively charged residues (Asp or Glu) at the active site.	Aspartic Acid	142-145	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	57-78
14763934-7	2004	RESULTS: Allergic bronchopulmonary aspergillosis patients had significantly increased IgE reactivity to Asp f2, f3, f4, f6, and f16 compared with the Af ST+ and ST- non-ABPA CF patients.	Aspartic Acid	104-107	immunoglobulin heavy constant epsilon	Homo sapiens	86-89
14763934-9	2004	In ABPA CF patients, IgE reactivity to Asp f1, f2, f3, and f6 significantly increased during periods of ABPA flares compared with periods of remission.	Aspartic Acid	39-42	immunoglobulin heavy constant epsilon	Homo sapiens	21-24
14763934-10	2004	Analysis of the receiver operating curve demonstrated that IgE reactivity to Asp f3 and f4 gave the best sensitivity and specificity and were better than IgE reactivity to a crude extract of Aspergillus.	Aspartic Acid	77-80	immunoglobulin heavy constant epsilon	Homo sapiens	59-62
14962809-7	2004	Inhibition of mineralization was localized to a small (2 kDa) cathepsin B released carboxy-terminal MEPE peptide (protease-resistant) containing the acidic serine-aspartate-rich motif (ASARM peptide).	Aspartic Acid	163-172	cathepsin B	Homo sapiens	62-73
14962809-7	2004	Inhibition of mineralization was localized to a small (2 kDa) cathepsin B released carboxy-terminal MEPE peptide (protease-resistant) containing the acidic serine-aspartate-rich motif (ASARM peptide).	Aspartic Acid	163-172	matrix extracellular phosphoglycoprotein	Homo sapiens	100-104
15016452-1	2004	Protein sequence alignments revealed one amino acid position, where organic cation transporters (OCTs, aspartate (D) at position 475 of rOCT2) and organic anion transporters (OATs, arginine (R) at position 466 of rOAT1) are charged oppositely.	Aspartic Acid	103-112	solute carrier family 22 member 2	Rattus norvegicus	136-141
15016452-4	2004	Heterologous expression of rOCT2 wild-type (rOCT2-wt) in A6 cells resulted in a significant uptake of the fluorescent organic cation 4-(4-dimethylaminostyryl)-N-methylpyridinium (ASP(+)).	Aspartic Acid	179-182	solute carrier family 22 member 2	Rattus norvegicus	27-32
15016452-4	2004	Heterologous expression of rOCT2 wild-type (rOCT2-wt) in A6 cells resulted in a significant uptake of the fluorescent organic cation 4-(4-dimethylaminostyryl)-N-methylpyridinium (ASP(+)).	Aspartic Acid	179-182	solute carrier family 22 member 2	Rattus norvegicus	44-49
15016452-6	2004	These data indicate that rOCT2 transports both ASP(+) and TEA and that aspartate at position 475 of rOCT2 plays a critical role in transport function.	Aspartic Acid	47-50	solute carrier family 22 member 2	Rattus norvegicus	25-30
14597635-4	2004	Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction.	Aspartic Acid	123-126	trio Rho guanine nucleotide exchange factor	Homo sapiens	118-122
15016452-6	2004	These data indicate that rOCT2 transports both ASP(+) and TEA and that aspartate at position 475 of rOCT2 plays a critical role in transport function.	Aspartic Acid	71-80	solute carrier family 22 member 2	Rattus norvegicus	100-105
14742879-6	2004	In planta assays showed that the Thr(168)-to-Asp-activated mutant SOS2 partially rescued the salt hypersensitivity in sos2 and sos3 mutant plants.	Aspartic Acid	45-48	Protein kinase superfamily protein	Arabidopsis thaliana	66-70
14742879-6	2004	In planta assays showed that the Thr(168)-to-Asp-activated mutant SOS2 partially rescued the salt hypersensitivity in sos2 and sos3 mutant plants.	Aspartic Acid	45-48	Protein kinase superfamily protein	Arabidopsis thaliana	118-122
14742879-6	2004	In planta assays showed that the Thr(168)-to-Asp-activated mutant SOS2 partially rescued the salt hypersensitivity in sos2 and sos3 mutant plants.	Aspartic Acid	45-48	Calcium-binding EF-hand family protein	Arabidopsis thaliana	127-131
14597635-4	2004	Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction.	Aspartic Acid	123-126	Rac family small GTPase 1	Homo sapiens	130-134
14670965-5	2004	A point mutation at aspartic acid 454 abolished association of the full S1 domain and of the 193-residue fragment with ACE2.	Aspartic Acid	20-33	angiotensin converting enzyme 2	Homo sapiens	119-123
14597635-4	2004	Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction.	Aspartic Acid	123-126	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	142-145
14597635-4	2004	Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction.	Aspartic Acid	123-126	Rac family small GTPase 1	Homo sapiens	222-226
14583620-4	2004	Sequence analysis showed that Dub-1A encodes a 468-amino acid protein that has a molecular mass of approximately 51 kDa and that contains a putative catalytic domain (Cys, His, and Asp) conserved among DUB proteins.	Aspartic Acid	181-184	ubiquitin specific peptidase 17-like B	Mus musculus	30-36
14559913-6	2004	The shared amino acid motif between HC3 and HC4 is composed of Asp(695)-Tyr-Asp-Tyr-Gln(699) (DYDYQ).	Aspartic Acid	63-66	CYCS pseudogene 24	Homo sapiens	36-39
14585837-2	2004	Mutational substitutions at 16 positions located in TM-III, -IV, -V, -VI, and -VII lining the main ligand-binding pocket of the CXCR4 receptor identified three acid residues: Asp(171) (AspIV:20), Asp(262) (AspVI:23), and Glu(288) (GluVII:06) as the main interaction points for AMD3100.	Aspartic Acid	175-178	C-X-C motif chemokine receptor 4	Homo sapiens	128-133
14585837-2	2004	Mutational substitutions at 16 positions located in TM-III, -IV, -V, -VI, and -VII lining the main ligand-binding pocket of the CXCR4 receptor identified three acid residues: Asp(171) (AspIV:20), Asp(262) (AspVI:23), and Glu(288) (GluVII:06) as the main interaction points for AMD3100.	Aspartic Acid	185-188	C-X-C motif chemokine receptor 4	Homo sapiens	128-133
14736843-0	2004	M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.	Aspartic Acid	62-71	potassium voltage-gated channel subfamily Q member 2	Rattus norvegicus	22-27
14734527-1	2004	The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not.	Aspartic Acid	107-110	major histocompatibility complex, class I, B	Homo sapiens	53-58
14734527-1	2004	The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not.	Aspartic Acid	107-110	major histocompatibility complex, class I, B	Homo sapiens	68-73
14734527-1	2004	The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not.	Aspartic Acid	107-110	major histocompatibility complex, class I, B	Homo sapiens	68-73
14734527-1	2004	The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not.	Aspartic Acid	107-110	major histocompatibility complex, class I, B	Homo sapiens	68-73
15176429-3	2004	Direct sequencing of the calsequestrin 2 (CASQ2), a candidate gene from within the linkage interval, revealed a negatively charged aspartic acid change to a positively charged histidine at position 307 of the protein.	Aspartic Acid	131-144	calsequestrin 2	Homo sapiens	25-40
15094828-9	2004	The replacement of Glu by Asp turned this peptide into an exclusive substrate for cathepsin B not hydrolyzed by papain.	Aspartic Acid	26-29	cathepsin B	Homo sapiens	82-93
14705935-0	2004	Mutational analysis provides molecular insight into the carbohydrate-binding region of calreticulin: pivotal roles of tyrosine-109 and aspartate-135 in carbohydrate recognition.	Aspartic Acid	135-144	calreticulin	Homo sapiens	87-99
15176429-3	2004	Direct sequencing of the calsequestrin 2 (CASQ2), a candidate gene from within the linkage interval, revealed a negatively charged aspartic acid change to a positively charged histidine at position 307 of the protein.	Aspartic Acid	131-144	calsequestrin 2	Homo sapiens	42-47
12948396-5	2004	While mutation of Thr-104, Glu-108, Asp-112 or Tyr-100 resulted in only minor changes to FXa-mediated thrombin generation, the functions of E96A (81%), D111A (70%) and D102A (60%) mutants (where the single-letter amino acid code is used) were notably reduced.	Aspartic Acid	36-39	coagulation factor X	Homo sapiens	89-92
14711628-4	2004	Since OmpT Asp(97) is proposed to interact with the P1" amino acid of its substrates, OmpT variants with variations at Asp(97) were constructed by replacing this amino acid with 19 natural amino acids to alter the cleavage specificity at Arg (P1)-Xaa (P1").	Aspartic Acid	11-14	outer membrane protease	Escherichia coli	6-10
14711628-4	2004	Since OmpT Asp(97) is proposed to interact with the P1" amino acid of its substrates, OmpT variants with variations at Asp(97) were constructed by replacing this amino acid with 19 natural amino acids to alter the cleavage specificity at Arg (P1)-Xaa (P1").	Aspartic Acid	119-122	outer membrane protease	Escherichia coli	6-10
14711628-4	2004	Since OmpT Asp(97) is proposed to interact with the P1" amino acid of its substrates, OmpT variants with variations at Asp(97) were constructed by replacing this amino acid with 19 natural amino acids to alter the cleavage specificity at Arg (P1)-Xaa (P1").	Aspartic Acid	119-122	outer membrane protease	Escherichia coli	86-90
15318931-6	2004	There was some indication that plasma estradiol and testosterone concentrations varied by UGT2B15 and SULT1A1 genotypes; women with the UGT2B15 Asp/Tyr and Tyr/Tyr genotypes had higher concentrations of estradiol than women with the Asp/Asp genotype (P = 0.004).	Aspartic Acid	144-147	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	136-143
14720321-2	2004	Previously, we constructed a mutant Smad3, Smad3D407E, which has an Asp to Glu mutation in the corresponding position of Smad2D450.	Aspartic Acid	68-71	SMAD family member 3	Homo sapiens	36-41
15318931-6	2004	There was some indication that plasma estradiol and testosterone concentrations varied by UGT2B15 and SULT1A1 genotypes; women with the UGT2B15 Asp/Tyr and Tyr/Tyr genotypes had higher concentrations of estradiol than women with the Asp/Asp genotype (P = 0.004).	Aspartic Acid	233-236	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	136-143
15318931-6	2004	There was some indication that plasma estradiol and testosterone concentrations varied by UGT2B15 and SULT1A1 genotypes; women with the UGT2B15 Asp/Tyr and Tyr/Tyr genotypes had higher concentrations of estradiol than women with the Asp/Asp genotype (P = 0.004).	Aspartic Acid	233-236	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	136-143
14732454-10	2004	These findings revealed that a single missense mutation (Asp298Asn) of aspartic acid (Asp) to asparagine (Asn) in MC4R gene decreased cAMP content and MC4R signaling, but with no difference in the ligand binding was associated with growth and feed intake traits in domestic pigs.	Aspartic Acid	71-84	melanocortin 4 receptor	Sus scrofa	114-118
14732454-10	2004	These findings revealed that a single missense mutation (Asp298Asn) of aspartic acid (Asp) to asparagine (Asn) in MC4R gene decreased cAMP content and MC4R signaling, but with no difference in the ligand binding was associated with growth and feed intake traits in domestic pigs.	Aspartic Acid	71-84	melanocortin 4 receptor	Sus scrofa	151-155
14732454-10	2004	These findings revealed that a single missense mutation (Asp298Asn) of aspartic acid (Asp) to asparagine (Asn) in MC4R gene decreased cAMP content and MC4R signaling, but with no difference in the ligand binding was associated with growth and feed intake traits in domestic pigs.	Aspartic Acid	57-60	melanocortin 4 receptor	Sus scrofa	114-118
14732454-10	2004	These findings revealed that a single missense mutation (Asp298Asn) of aspartic acid (Asp) to asparagine (Asn) in MC4R gene decreased cAMP content and MC4R signaling, but with no difference in the ligand binding was associated with growth and feed intake traits in domestic pigs.	Aspartic Acid	57-60	melanocortin 4 receptor	Sus scrofa	151-155
14699510-6	2004	We detected a germline PDGFRA missense mutation, 2675G &gt; T, resulting in a tyrosine substitution for the highly conserved aspartic acid at codon 846.	Aspartic Acid	125-138	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	23-29
14717697-10	2004	Phosphorylation of Hsp27 by mitogen activated protein kinase-activated protein kinase 2 was mimicked by replacing Ser15, 78 and 82 with Asp.	Aspartic Acid	136-139	heat shock protein family B (small) member 1	Homo sapiens	19-24
14717697-10	2004	Phosphorylation of Hsp27 by mitogen activated protein kinase-activated protein kinase 2 was mimicked by replacing Ser15, 78 and 82 with Asp.	Aspartic Acid	136-139	MAPK activated protein kinase 2	Homo sapiens	28-87
15752073-3	2004	This family of hypothetical proteins is referred to as SDH proteinase family based on conserved sequential order of Ser, Asp and His residues and predicted serine proteinase activity.	Aspartic Acid	121-124	serine dehydratase	Homo sapiens	55-58
15752073-5	2004	However, the best sequence alignment we could obtain suggests that while catalytic Ser is conserved across Clp and SDH proteinases the location of the other catalytic triad residues, namely, His and Asp are swapped in their amino acid alignment positions and hence in 3-D structure.	Aspartic Acid	199-202	calmodulin like 3	Homo sapiens	107-110
15752073-5	2004	However, the best sequence alignment we could obtain suggests that while catalytic Ser is conserved across Clp and SDH proteinases the location of the other catalytic triad residues, namely, His and Asp are swapped in their amino acid alignment positions and hence in 3-D structure.	Aspartic Acid	199-202	serine dehydratase	Homo sapiens	115-118
14998162-5	2004	Essentially, all of the amide bond cleavages associated with the +10 charge state of fully guanidinated ubiquitin were observed to occur C-terminal to aspartic acid residues, unlike the dissociation behavior of the +10 ion of the unmodified protein, where competing cleavage N-terminal to proline and nonspecific amide bond cleavages were also observed.	Aspartic Acid	151-164	ubiquitin	Bos taurus	104-113
14734683-4	2004	METHODS: A short linear alpha-MSH analog, [Nle(4),Asp(5),D-Phe(7)]-alpha-MSH(4-11) (NAPamide), was newly designed and conjugated to the metal chelator DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) to enable radiometal incorporation.	Aspartic Acid	50-53	pro-opiomelanocortin-alpha	Mus musculus	24-33
14734683-4	2004	METHODS: A short linear alpha-MSH analog, [Nle(4),Asp(5),D-Phe(7)]-alpha-MSH(4-11) (NAPamide), was newly designed and conjugated to the metal chelator DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) to enable radiometal incorporation.	Aspartic Acid	50-53	msh homeobox 1	Mus musculus	30-33
15323354-2	2004	Analysis of known protein disulphide isomerase and thioredoxin sequences has revealed the presence of conserved Cys, His and Asp residues required for transglutaminases to catalyze the incorporation of primary amines into protein-bound glutamine residues.	Aspartic Acid	125-128	prolyl 4-hydroxylase subunit beta	Homo sapiens	18-46
15323354-2	2004	Analysis of known protein disulphide isomerase and thioredoxin sequences has revealed the presence of conserved Cys, His and Asp residues required for transglutaminases to catalyze the incorporation of primary amines into protein-bound glutamine residues.	Aspartic Acid	125-128	thioredoxin	Homo sapiens	51-62
14998166-4	2004	We present a number of novel examples (Kruppel transcription factors; Pbx2; Enc1) from the ASP database, illustrating how this pattern of alternative splicing changes the structure of a biological pathway, by redirecting protein interaction networks at key switch points.	Aspartic Acid	91-94	PBX homeobox 2	Homo sapiens	70-74
14998166-4	2004	We present a number of novel examples (Kruppel transcription factors; Pbx2; Enc1) from the ASP database, illustrating how this pattern of alternative splicing changes the structure of a biological pathway, by redirecting protein interaction networks at key switch points.	Aspartic Acid	91-94	ectodermal-neural cortex 1	Homo sapiens	76-80
15697092-6	2004	Direct DNA sequencing of the amplified beta-globin genes of both probands identified the GGT (Gly)-GAT (Asp) mutation at codon 136 corresponding to Hb Hope.	Aspartic Acid	104-107	gamma-glutamyltransferase light chain 5 pseudogene	Homo sapiens	89-102
15697091-1	2004	Hemoglobin Q-India is a very rare alpha-chain structural variant caused by the mutation AAG--&gt;GAG (Asp--&gt;His) in the position of codon 64 of the alpha1 gene.	Aspartic Acid	102-105	adrenoceptor alpha 1D	Homo sapiens	151-157
15697092-6	2004	Direct DNA sequencing of the amplified beta-globin genes of both probands identified the GGT (Gly)-GAT (Asp) mutation at codon 136 corresponding to Hb Hope.	Aspartic Acid	104-107	hemoglobin subunit beta	Homo sapiens	39-50
14707445-7	2004	RESULTS: One renal pelvic TCC (0.9%: 1/108) had a single-base substitution in p53R2 with a G to T transversion resulting in the amino acid substitution Glu136 --&gt; Asp.	Aspartic Acid	166-169	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	78-83
14701727-1	2004	Adult-onset type II citrullinemia (CTLN2) is an autosomal recessive disease caused by mutations in SLC25A13, the gene encoding the mitochondrial aspartate/glutamate carrier citrin.	Aspartic Acid	145-154	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	99-107
14701727-1	2004	Adult-onset type II citrullinemia (CTLN2) is an autosomal recessive disease caused by mutations in SLC25A13, the gene encoding the mitochondrial aspartate/glutamate carrier citrin.	Aspartic Acid	145-154	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	173-179
14692784-3	2003	Two independent molecular dynamics (MD) simulations of BACE in complex with the potent inhibitor OM99-2 are carried out to determine the preferred protonation state of the Asp diad in the context that is consistent with the previous X-ray crystal structure.	Aspartic Acid	172-175	beta-secretase 1	Homo sapiens	55-59
15381393-7	2004	Cells spreading on immobilized soluble fibrin were blocked by the exogenous addition of soluble fibrin and glycine-arginine-glycine-aspartic acid-serine-phenylalanine (GRGDSP)-synthetic peptide but not by the addition of fibrinogen or fibrin monomer.	Aspartic Acid	132-145	fibrinogen beta chain	Homo sapiens	221-231
14981828-5	2004	Amino acid analysis revealed the DPP contained mainly Asp (41.2%) and Ser (28.5%).	Aspartic Acid	54-57	dentin sialophosphoprotein	Homo sapiens	33-36
14981828-7	2004	Its relative molecular mass was determined to be 76 x 10(3)-140 x 10(3), and its constitution characterized by abundant Asp and Ser resembles that of DPP extracted from the teeth with immature apices.	Aspartic Acid	120-123	dentin sialophosphoprotein	Homo sapiens	150-153
14532276-3	2003	Using site-directed mutagenesis, we prepared recombinant RyR1 and RyR2 mutant receptors mimicking constitutively phosphorylated and dephosphorylated channels carrying a Ser/Asp (RyR1-S2843D and RyR2-S2809D) and Ser/Ala (RyR1-S2843A and RyR2-S2809A) substitution, respectively.	Aspartic Acid	173-176	ryanodine receptor 1	Homo sapiens	178-182
14532276-3	2003	Using site-directed mutagenesis, we prepared recombinant RyR1 and RyR2 mutant receptors mimicking constitutively phosphorylated and dephosphorylated channels carrying a Ser/Asp (RyR1-S2843D and RyR2-S2809D) and Ser/Ala (RyR1-S2843A and RyR2-S2809A) substitution, respectively.	Aspartic Acid	173-176	ryanodine receptor 1	Homo sapiens	178-182
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	43-46	F2R like thrombin or trypsin receptor 3	Homo sapiens	9-13
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	43-46	F2R like thrombin or trypsin receptor 3	Homo sapiens	140-144
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	43-46	coagulation factor II, thrombin	Homo sapiens	163-171
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	53-56	F2R like thrombin or trypsin receptor 3	Homo sapiens	9-13
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	53-56	F2R like thrombin or trypsin receptor 3	Homo sapiens	140-144
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	53-56	coagulation factor II, thrombin	Homo sapiens	163-171
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	53-56	F2R like thrombin or trypsin receptor 3	Homo sapiens	9-13
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	53-56	F2R like thrombin or trypsin receptor 3	Homo sapiens	140-144
13678420-5	2003	Instead, PAR4 contains an anionic cluster, Asp(57)...Asp(59) ...Glu(62)...Asp(65) (DDED), in its exodomain, which slows the dissociation of PAR4 from the cationic thrombin.	Aspartic Acid	53-56	coagulation factor II, thrombin	Homo sapiens	163-171
14654783-7	2003	Substitution of S407 with aspartate (S407D), but not with alanine (S407A), promotes nuclear localization of p53.	Aspartic Acid	26-35	tumor protein p53	Homo sapiens	108-111
14667898-0	2003	The Glu298--&gt;Asp polymorphism of the endothelial nitric oxide synthase gene is associated with endometriosis.	Aspartic Acid	16-19	nitric oxide synthase 3	Homo sapiens	40-73
14633983-5	2003	Phosphorylation of Ser278 by CK2 or a Ser278--&gt;Asp mutation increased the interaction between PACS-1 and cargo, whereas a Ser278--&gt;Ala substitution decreased this interaction.	Aspartic Acid	50-53	phosphofurin acidic cluster sorting protein 1	Homo sapiens	97-103
14635113-0	2003	A pathogenic glutamate-to-aspartate substitution (D296E) in the pyruvate dehydrogenase E1 subunit gene PDHA1.	Aspartic Acid	26-35	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	103-108
14654359-6	2003	Unlike wild-type hirudin, the variant comprising Pro(50)- ...-His(56)-Asp(57)- ...-Pro(62)-Pro(63)-His(64) is completely resistant to pepsin and chymotrypsin cleavage; however, this is at the expense of thrombin inhibition activity where there is a 100-fold increase in the IC50 value.	Aspartic Acid	70-73	coagulation factor II, thrombin	Homo sapiens	203-211
14645576-7	2003	Consistent with this hypothesis, we have previously shown that cdc34 physically interacts with ICP0 at or near aspartate 199 and at amino acids 621 to 625 and that the former site is required for effective ubiquitylation and degradation of cdc34.	Aspartic Acid	111-120	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	63-68
14983068-8	2003	Instead, we propose that two fully conserved Asp residues (Asp43 and Asp123), not present in PSPs contribute to substrate specificity in PHOSPHO1.	Aspartic Acid	45-48	phosphoethanolamine/phosphocholine phosphatase 1	Homo sapiens	137-145
14627736-7	2003	Sequence alignment and structural comparison suggest that these Arg-Asp interactions are highly conserved in SF2 DEx(D/H) proteins.	Aspartic Acid	68-71	serine and arginine rich splicing factor 1	Homo sapiens	109-112
14615587-0	2003	Conversion of the allosteric transition of GroEL from concerted to sequential by the single mutation Asp-155 -&gt; Ala.	Aspartic Acid	101-104	heat shock protein family D (Hsp60) member 1	Homo sapiens	43-48
12954649-5	2003	In addition, Asp-634 within the Shank1 PDZ domain recognizes the positively charged Arg at -1 position and hydrogen bonds, and salt bridges between Arg-607 and the side chains of the ligand at -3 and -5 positions contribute further to the recognition of the peptide ligand.	Aspartic Acid	13-16	SH3 and multiple ankyrin repeat domains 1	Homo sapiens	32-38
14647472-2	2003	We have previously shown that aspartic acid and glutamic acid substitution (AspGlu and GluAsp) of the activation loop tyrosines in TrkA (Tyr(683) and Tyr(684)) supports NGF-independent neuritogenesis and cell survival in PC12 cell-derived nnr5 cells.	Aspartic Acid	30-43	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	131-135
14615587-4	2003	Electron microscopy analysis of single-ring GroEL particles containing the Asp-155 --&gt; Ala mutation shows that the break in intra-ring symmetry is due to stabilization of allosteric intermediates such as one in which three subunits have switched their conformation while the other four have not.	Aspartic Acid	75-78	heat shock protein family D (Hsp60) member 1	Homo sapiens	44-49
14615587-5	2003	Our results show that eliminating an intra-subunit interaction between Asp-155 and Arg-395 results in conversion of the allosteric switch of GroEL from concerted to sequential, thus demonstrating that its allosteric behavior arises from coupled tertiary conformational changes.	Aspartic Acid	71-74	heat shock protein family D (Hsp60) member 1	Homo sapiens	141-146
12954620-0	2003	Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state.	Aspartic Acid	158-167	ATP binding cassette subfamily B member 1	Homo sapiens	92-122
14647472-2	2003	We have previously shown that aspartic acid and glutamic acid substitution (AspGlu and GluAsp) of the activation loop tyrosines in TrkA (Tyr(683) and Tyr(684)) supports NGF-independent neuritogenesis and cell survival in PC12 cell-derived nnr5 cells.	Aspartic Acid	30-43	nerve growth factor	Rattus norvegicus	169-172
12954620-0	2003	Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state.	Aspartic Acid	158-167	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
12954620-0	2003	Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state.	Aspartic Acid	158-167	ATP binding cassette subfamily C member 1	Homo sapiens	129-134
14563493-8	2003	C5aR mutated to either Ala or Asp at this position lost nearly all responsiveness to both C5a and C5a des-Arg(74), suggesting that mutation of Arg(175) caused a non-specific loss of receptor conformation and a loss of signalling capacity.	Aspartic Acid	30-33	complement C5a receptor 1	Homo sapiens	0-4
14563493-8	2003	C5aR mutated to either Ala or Asp at this position lost nearly all responsiveness to both C5a and C5a des-Arg(74), suggesting that mutation of Arg(175) caused a non-specific loss of receptor conformation and a loss of signalling capacity.	Aspartic Acid	30-33	complement C5a receptor 1	Homo sapiens	0-3
14563493-8	2003	C5aR mutated to either Ala or Asp at this position lost nearly all responsiveness to both C5a and C5a des-Arg(74), suggesting that mutation of Arg(175) caused a non-specific loss of receptor conformation and a loss of signalling capacity.	Aspartic Acid	30-33	complement C5a receptor 1	Homo sapiens	90-93
14628683-1	2003	Using a bisubstituted caspase-3 target sequence: aspartate-glutamate-valine-aspartate, (z-DEVD)2 peptide derivative of the fluorophore, cresyl violet, we have obtained a cell permeant, fluorogenic, caspase substrate capable of detecting the site-specific presence of functionally active, caspase-3 and caspase-7 up-regulation within intact apoptotic cells.	Aspartic Acid	49-59	caspase 3	Homo sapiens	22-31
14613286-8	2003	CONCLUSION: Our findings show that the Glu/Asp(298) polymorphism of the eNOS gene is associated with GCA susceptibility.	Aspartic Acid	43-46	nitric oxide synthase 3	Homo sapiens	72-76
12922151-1	2003	Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature 309 (1984) 30), numerous materials have been RGD functionalized for academic studies or medical applications.	Aspartic Acid	48-61	fibronectin 1	Homo sapiens	141-152
14628683-1	2003	Using a bisubstituted caspase-3 target sequence: aspartate-glutamate-valine-aspartate, (z-DEVD)2 peptide derivative of the fluorophore, cresyl violet, we have obtained a cell permeant, fluorogenic, caspase substrate capable of detecting the site-specific presence of functionally active, caspase-3 and caspase-7 up-regulation within intact apoptotic cells.	Aspartic Acid	49-59	caspase 3	Homo sapiens	288-297
14628683-1	2003	Using a bisubstituted caspase-3 target sequence: aspartate-glutamate-valine-aspartate, (z-DEVD)2 peptide derivative of the fluorophore, cresyl violet, we have obtained a cell permeant, fluorogenic, caspase substrate capable of detecting the site-specific presence of functionally active, caspase-3 and caspase-7 up-regulation within intact apoptotic cells.	Aspartic Acid	49-59	caspase 7	Homo sapiens	302-311
14632798-0	2003	Aspartic acid racemization: evidence for marked longevity of elastin in human skin.	Aspartic Acid	0-13	elastin	Homo sapiens	61-68
14632798-9	2003	CONCLUSIONS: The age-dependent accumulation of modified aspartic acid residues appears to be a common feature in ageing elastin, independent of the tissue source.	Aspartic Acid	56-69	elastin	Homo sapiens	120-127
12917435-9	2003	4) mu-Calpain produced a loss of the DEVDase (Asp-Glu-Val-Asp) activity of active caspase-3.	Aspartic Acid	46-49	caspase 3	Rattus norvegicus	82-91
14500544-4	2003	We examined the influence of ASP or MSH on Mc1r gene expression, and we report that both ligands influence the Mc1r 5" promoter structure in distinct manners.	Aspartic Acid	29-32	melanocortin 1 receptor	Homo sapiens	111-115
14622413-7	2003	However, unlike its human orthologues, yeast Agc1p catalyses both aspartate-glutamate exchange and substrate uniport activities.	Aspartic Acid	66-75	citrin	Saccharomyces cerevisiae S288C	45-50
14561887-6	2003	Mutation of an aspartic acid residue (D256) that is conserved in all Pus7 homologs abolishes the enzymatic activity both in vivo and in vitro.	Aspartic Acid	15-28	pseudouridine synthase PUS7	Saccharomyces cerevisiae S288C	69-73
14705865-5	2003	Subsequently, the Apaf-1/caspase-9 holoenzyme complex recruits the effector caspase-3 via an interaction between the active site cysteine in caspase-9 and the critical aspartate, which is the cleavage site for generating the large and small subunits of caspase-3 that constitute the activated form of caspase-3.	Aspartic Acid	168-177	apoptotic peptidase activating factor 1	Homo sapiens	18-24
14705865-5	2003	Subsequently, the Apaf-1/caspase-9 holoenzyme complex recruits the effector caspase-3 via an interaction between the active site cysteine in caspase-9 and the critical aspartate, which is the cleavage site for generating the large and small subunits of caspase-3 that constitute the activated form of caspase-3.	Aspartic Acid	168-177	caspase 9	Homo sapiens	25-34
14705865-5	2003	Subsequently, the Apaf-1/caspase-9 holoenzyme complex recruits the effector caspase-3 via an interaction between the active site cysteine in caspase-9 and the critical aspartate, which is the cleavage site for generating the large and small subunits of caspase-3 that constitute the activated form of caspase-3.	Aspartic Acid	168-177	caspase 3	Homo sapiens	76-85
14705865-5	2003	Subsequently, the Apaf-1/caspase-9 holoenzyme complex recruits the effector caspase-3 via an interaction between the active site cysteine in caspase-9 and the critical aspartate, which is the cleavage site for generating the large and small subunits of caspase-3 that constitute the activated form of caspase-3.	Aspartic Acid	168-177	caspase 9	Homo sapiens	141-150
14705865-5	2003	Subsequently, the Apaf-1/caspase-9 holoenzyme complex recruits the effector caspase-3 via an interaction between the active site cysteine in caspase-9 and the critical aspartate, which is the cleavage site for generating the large and small subunits of caspase-3 that constitute the activated form of caspase-3.	Aspartic Acid	168-177	caspase 3	Homo sapiens	253-262
14705865-5	2003	Subsequently, the Apaf-1/caspase-9 holoenzyme complex recruits the effector caspase-3 via an interaction between the active site cysteine in caspase-9 and the critical aspartate, which is the cleavage site for generating the large and small subunits of caspase-3 that constitute the activated form of caspase-3.	Aspartic Acid	168-177	caspase 3	Homo sapiens	253-262
14622120-0	2003	The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier.	Aspartic Acid	36-49	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	65-70
14622120-6	2003	Indeed, l-Asp uptake by oocytes injected with either ASCT1 or ASCT2 cRNA took place in a similar manner to that in cultured BBB cells, whereas no significant d-Asp uptake occurred.	Aspartic Acid	8-13	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	Mus musculus	53-58
14622120-6	2003	Indeed, l-Asp uptake by oocytes injected with either ASCT1 or ASCT2 cRNA took place in a similar manner to that in cultured BBB cells, whereas no significant d-Asp uptake occurred.	Aspartic Acid	8-13	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	62-67
14622120-9	2003	These results suggest that ASCT2 plays a key role in l-isomer-selective Asp efflux transport at the BBB.	Aspartic Acid	72-75	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	27-32
12885769-0	2003	Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.	Aspartic Acid	23-26	presenilin enhancer, gamma-secretase subunit	Homo sapiens	50-55
12885769-0	2003	Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.	Aspartic Acid	34-37	presenilin enhancer, gamma-secretase subunit	Homo sapiens	50-55
12890670-7	2003	We found that a mutant (DGK zeta S/D) in which serines within the MARCKS PSD were altered to aspartates (to mimic phosphorylation) had lower activity compared with wild-type DGK zeta or a control mutant (DGK zeta S/N) in which the same serines were changed to asparagines.	Aspartic Acid	93-103	diacylglycerol kinase beta	Homo sapiens	24-27
14561230-6	2003	Results here are the first to show that the efficacy of ion channel activation is decreased by mutations of AQP1 at conserved residues in the C-terminal domain (aspartate D237 and lysine K243).	Aspartic Acid	161-170	aquaporin 1 (Colton blood group)	Homo sapiens	108-112
14636557-4	2003	We entitle it Taspase1 as it initiates a class of endopeptidases that utilize an N-terminal threonine as the active site nucleophile to proteolyze polypeptide substrates following aspartate.	Aspartic Acid	180-189	Taspase 1	Drosophila melanogaster	14-22
12909616-3	2003	Using adult feline cardiomyocytes, here we report that integrin-interacting Arg-Gly-Asp (RGD) peptides activate S6K1 as observed by band shifting, kinase activity and phosphorylation at Thr-389 and Thr-421/Ser-424 of S6K1, and S6 protein phosphorylation.	Aspartic Acid	84-87	ribosomal protein S6 kinase B1	Homo sapiens	112-116
12909616-3	2003	Using adult feline cardiomyocytes, here we report that integrin-interacting Arg-Gly-Asp (RGD) peptides activate S6K1 as observed by band shifting, kinase activity and phosphorylation at Thr-389 and Thr-421/Ser-424 of S6K1, and S6 protein phosphorylation.	Aspartic Acid	84-87	ribosomal protein S6 kinase B1	Homo sapiens	217-221
12966028-2	2003	The defining features of the PSs and SPP are their ability to cleave substrate polypeptides within a transmembrane region, the presence of two active site aspartate residues in adjacent membrane-spanning regions and a conserved PAL motif near their COOH-terminus.	Aspartic Acid	155-164	histocompatibility minor 13	Homo sapiens	37-40
12890670-7	2003	We found that a mutant (DGK zeta S/D) in which serines within the MARCKS PSD were altered to aspartates (to mimic phosphorylation) had lower activity compared with wild-type DGK zeta or a control mutant (DGK zeta S/N) in which the same serines were changed to asparagines.	Aspartic Acid	93-103	diacylglycerol kinase zeta	Homo sapiens	24-32
12882957-11	2003	The decrease in transport caused by the Asp to Glu mutation in NBD1 is associated with an inability of MRP1 to shift from high to low affinity substrate binding states.	Aspartic Acid	40-43	ATP binding cassette subfamily C member 1	Homo sapiens	103-107
12816867-1	2003	Bax is cleaved by calpain at aspartate 33 (Asp33) to yield p18 Bax during stress-induced apoptosis.	Aspartic Acid	29-38	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
14499613-6	2003	A docking model using the crystal structure of integrin alphaVbeta3 suggests that the Arg binds to the propeller domain, and Asp to the betaA domain.	Aspartic Acid	125-128	integrin subunit alpha V	Homo sapiens	47-67
14553962-6	2003	After adjustment for covariates, the endothelial nitric oxide synthase Glu298--&gt;Asp polymorphism made an additional statistically significant contribution to predicting diastolic BP response to hydrochlorothiazide, accounting for another 1% of interindividual variation in response (P =.034).	Aspartic Acid	83-86	nitric oxide synthase 3	Homo sapiens	37-70
14644554-6	2003	S. salivarius MetAP has a pH optimum of 8.0 and an optimal temperature at 50 degrees C. The S. salivarius protein had an extra sequence of 24 amino acids between two conserved aspartate residues involved in the coordination of the metal ion.	Aspartic Acid	176-185	SSAL8618_RS07945	Streptococcus salivarius	14-19
12816867-1	2003	Bax is cleaved by calpain at aspartate 33 (Asp33) to yield p18 Bax during stress-induced apoptosis.	Aspartic Acid	29-38	H3 histone pseudogene 12	Homo sapiens	59-62
12816867-1	2003	Bax is cleaved by calpain at aspartate 33 (Asp33) to yield p18 Bax during stress-induced apoptosis.	Aspartic Acid	29-38	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66
14527840-9	2003	In participants with the Asp allele, longer duration working with lead was associated with higher serum creatinine and lower calculated creatinine clearance and NAG; all were significantly different from relations in those with the Glu/Glu genotype except NAG (p = 0.08).	Aspartic Acid	25-28	O-GlcNAcase	Homo sapiens	161-164
14559822-6	2003	The cleavage is site specific at Asp-52 and is restricted to effector caspase-3 and -7.	Aspartic Acid	33-36	caspase 3	Homo sapiens	70-86
12844488-8	2003	However, the p53 mutation frequency increased with the increased number of the combined genotypes among XPD 312WT (Asp/Asp), XPD 751VT (Lys/Gln or Gln/Gln) or XRCC1 399VT (Arg/Gln or Gln/Gln) (P = 0.01, trend test).	Aspartic Acid	115-118	tumor protein p53	Homo sapiens	13-16
12844488-8	2003	However, the p53 mutation frequency increased with the increased number of the combined genotypes among XPD 312WT (Asp/Asp), XPD 751VT (Lys/Gln or Gln/Gln) or XRCC1 399VT (Arg/Gln or Gln/Gln) (P = 0.01, trend test).	Aspartic Acid	119-122	tumor protein p53	Homo sapiens	13-16
12844488-9	2003	These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair.	Aspartic Acid	76-79	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	62-65
12844488-9	2003	These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair.	Aspartic Acid	76-79	tumor protein p53	Homo sapiens	121-124
12844488-9	2003	These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair.	Aspartic Acid	80-83	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	62-65
12844488-9	2003	These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair.	Aspartic Acid	80-83	tumor protein p53	Homo sapiens	121-124
14529742-1	2003	We have isolated a 1586-bp full-length CITED3 cDNA from grass carp which specifies for a cAMP-responsive element-binding protein/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich C-terminal domain protein.	Aspartic Acid	184-197	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b	Danio rerio	39-45
14555477-8	2003	Replacement of T42 with a phosphorylation-mimetic aspartic acid residue (T42D) permits wild-type function in all assays of Ste50p function.	Aspartic Acid	50-63	Ste50p	Saccharomyces cerevisiae S288C	123-129
14500747-3	2003	We have shown previously that syntaxin 1A exerts its effects on GAT1 by decreasing the net uptake of GABA and its associated ions through interactions with aspartic acid residues in the N-terminal tail of GAT1.	Aspartic Acid	156-169	syntaxin 1A	Rattus norvegicus	30-41
14642351-11	2003	As an alternative to complete removal of the loop domain, Bcl-x(L) variants were created in which aspartate residues containing potential caspase recognition sites within the loop domain of Bcl-x(L) were removed.	Aspartic Acid	98-107	BCL2 like 1	Homo sapiens	58-66
14642351-11	2003	As an alternative to complete removal of the loop domain, Bcl-x(L) variants were created in which aspartate residues containing potential caspase recognition sites within the loop domain of Bcl-x(L) were removed.	Aspartic Acid	98-107	BCL2 like 1	Homo sapiens	190-198
12972622-5	2003	We find that in the presence of Ca(2+) influx, the catalytically active PKCalphaA25E induces IKK activity and NF-kappaB-dependent transcription; which is abrogated following the mutations of two aspartates at positions 246 and 248, which are required for Ca(2+) binding to PKCalpha and cell membrane recruitment.	Aspartic Acid	195-205	nuclear factor kappa B subunit 1	Homo sapiens	110-119
12972622-5	2003	We find that in the presence of Ca(2+) influx, the catalytically active PKCalphaA25E induces IKK activity and NF-kappaB-dependent transcription; which is abrogated following the mutations of two aspartates at positions 246 and 248, which are required for Ca(2+) binding to PKCalpha and cell membrane recruitment.	Aspartic Acid	195-205	protein kinase C alpha	Homo sapiens	72-80
14500747-3	2003	We have shown previously that syntaxin 1A exerts its effects on GAT1 by decreasing the net uptake of GABA and its associated ions through interactions with aspartic acid residues in the N-terminal tail of GAT1.	Aspartic Acid	156-169	solute carrier family 6 member 12	Rattus norvegicus	64-68
14500747-3	2003	We have shown previously that syntaxin 1A exerts its effects on GAT1 by decreasing the net uptake of GABA and its associated ions through interactions with aspartic acid residues in the N-terminal tail of GAT1.	Aspartic Acid	156-169	solute carrier family 6 member 12	Rattus norvegicus	205-209
12941338-3	2003	The crystal structure of the 4"-carboxamide derivative, in complex with phospho-Thr160 CDK2/cyclin A, confirmed the expected binding mode of the inhibitor, and revealed an additional interaction between the carboxamide function and an aspartate residue.	Aspartic Acid	235-244	cyclin dependent kinase 2	Homo sapiens	87-91
12874287-15	2003	Acidic residues corresponding to HMG-CoA lyase Asp-42 and Glu-72 are conserved in the HMG-CoA lyase protein family, which includes proteins that utilize acetyl-CoA in aldol condensations.	Aspartic Acid	47-50	3-hydroxy-3-methylglutaryl-CoA lyase	Homo sapiens	33-46
12874287-15	2003	Acidic residues corresponding to HMG-CoA lyase Asp-42 and Glu-72 are conserved in the HMG-CoA lyase protein family, which includes proteins that utilize acetyl-CoA in aldol condensations.	Aspartic Acid	47-50	3-hydroxy-3-methylglutaryl-CoA lyase	Homo sapiens	86-99
14517296-3	2003	We show here, by yeast two-hybrid screenings and biochemical assays, that a region at the amino terminus of the human nuclear pore complex protein Nup96 interacts with the WD (Trp-Asp) repeat region of human Sec13.	Aspartic Acid	180-183	nucleoporin 98 and 96 precursor	Homo sapiens	147-152
14517296-3	2003	We show here, by yeast two-hybrid screenings and biochemical assays, that a region at the amino terminus of the human nuclear pore complex protein Nup96 interacts with the WD (Trp-Asp) repeat region of human Sec13.	Aspartic Acid	180-183	SEC13 homolog, nuclear pore and COPII coat complex component	Homo sapiens	208-213
14731360-10	2003	RESULTS: Six hours after CPR, the CK-MB and cTnT in ASP group [(423 +/- 156) IU/L and (0.85 +/- 0.64) microg/L] were both higher than those in CON group [(213 +/- 30) IU/L and (0.08 +/- 0.02) microg/L, P &lt; 0.01].	Aspartic Acid	52-55	troponin T2, cardiac type	Homo sapiens	44-48
12968876-3	2003	They are found to be stable for several months when stored at 4 degrees C. The acyl azides of Asp, Glu, Ser, Tyr, and Lys with side-chain protection having tert-butyl, benzyl, and Boc groups were also converted to the corresponding isocyanates 2h-m.	Aspartic Acid	94-97	BOC cell adhesion associated, oncogene regulated	Homo sapiens	180-183
12941338-3	2003	The crystal structure of the 4"-carboxamide derivative, in complex with phospho-Thr160 CDK2/cyclin A, confirmed the expected binding mode of the inhibitor, and revealed an additional interaction between the carboxamide function and an aspartate residue.	Aspartic Acid	235-244	cyclin A2	Homo sapiens	92-100
14499900-4	2003	We also show that the ionization state of a network of five histidines, His108, His119, His121, His132 and His137, and two aspartic acids Asp141 and Asp144, contributes approximately 12 kcal/mol to the stability of the catalytic site of GART, out of a total stability of 16 kcal/mol of the whole enzyme.	Aspartic Acid	123-137	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	237-241
12807887-6	2003	Adhesion to microfibrils and to Arg-Gly-Asp containing fibrillin-1 protein fragments induced signaling events that led to cell spreading, altered cytoskeletal organization, and enhanced extracellular fibrillin-1 deposition.	Aspartic Acid	40-43	fibrillin 1	Homo sapiens	55-66
12807887-6	2003	Adhesion to microfibrils and to Arg-Gly-Asp containing fibrillin-1 protein fragments induced signaling events that led to cell spreading, altered cytoskeletal organization, and enhanced extracellular fibrillin-1 deposition.	Aspartic Acid	40-43	fibrillin 1	Homo sapiens	200-211
12807887-8	2003	An Arg-Gly-Asp-independent cell adhesion sequence was also identified within fibrillin-1.	Aspartic Acid	11-14	fibrillin 1	Homo sapiens	77-88
12807887-10	2003	A375-SM melanoma cells bound Arg-Gly-Asp-containing fibrillin-1 protein fragments mainly through alpha v beta 3, whereas HT1080 cells used mainly alpha 5 beta 1.	Aspartic Acid	37-40	fibrillin 1	Homo sapiens	52-63
27265574-0	2003	First Observation of Hemoglobin Pyrgos [ss83(EF7) Gly Asp] in Turkish Population.	Aspartic Acid	54-57	FAM3 metabolism regulating signaling molecule D	Homo sapiens	45-48
12810727-2	2003	By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in human BACAT (hBACAT) and identifying BACAT as a member of the type I acyl-CoA thioesterase gene family.	Aspartic Acid	90-93	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	154-159
12810727-2	2003	By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in human BACAT (hBACAT) and identifying BACAT as a member of the type I acyl-CoA thioesterase gene family.	Aspartic Acid	90-93	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	161-167
12810727-2	2003	By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in human BACAT (hBACAT) and identifying BACAT as a member of the type I acyl-CoA thioesterase gene family.	Aspartic Acid	90-93	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	162-167
12939145-1	2003	In the elucidation of structural requirements of heme vicinity for hydrogen peroxide activation, we found that the replacement of His-64 of myoglobin (Mb) with a negatively charged aspartate residue enhanced peroxidase and peroxygenase activities by 78- and 580-fold, respectively.	Aspartic Acid	181-190	myoglobin	Homo sapiens	140-149
14501969-2	2003	This project sought to determine the relationship between the apoE4 allele and the recovery of amino acid neurotransmitters (aspartate, glutamate, and lactate/pyruvate ratio [L/P]) following a traumatic brain injury (TBI) after controlling for patient characteristics.	Aspartic Acid	125-134	apolipoprotein E	Homo sapiens	62-67
14501969-8	2003	There was a significant apoE4 allele group effect on both the linear and quadratic slopes in aspartate.	Aspartic Acid	93-102	apolipoprotein E	Homo sapiens	24-29
12963350-1	2003	Enteropeptidase (synonym:enterokinase, EC 3.4.21.9) is a heterodimeric serine protease of the intestinal brush border that activates trypsinogen by highly specific cleavage of the trypsinogen activation peptide following the sequence (Asp)(4)-Lys.	Aspartic Acid	235-238	transmembrane serine protease 15	Homo sapiens	0-15
12947056-6	2003	K-ras codon 13 mutations (all with G-A nucleotide transitions resulting in Gly&gt;Asp substitution) and single activating mutations in any of the ras genes were also independent predictors of poor survival in differentiated thyroid carcinomas (P =.027 and P =.007, respectively).	Aspartic Acid	82-85	KRAS proto-oncogene, GTPase	Homo sapiens	0-5
14614264-6	2003	Glutamate also decreased by about 25% between P11 and P15, on the other hand, aspartate diminished by about 20% between P7 and P9.	Aspartic Acid	78-87	solute carrier family 10 (sodium/bile acid cotransporter family), member 7	Mus musculus	120-129
12968710-3	2003	1 and 2, pretreatment of mares with TRH (10 microg/kg BW) decreased (P &lt; 0.001) the GH response to exercise and aspartate infusion.	Aspartic Acid	115-124	thyrotropin releasing hormone	Equus caballus	36-39
12968710-20	2003	In summary, TRH inhibited exercise- and aspartate-induced GH secretion.	Aspartic Acid	40-49	thyrotropin releasing hormone	Equus caballus	12-15
14523936-6	2003	The analog DOTA-[betaAla(3), Nle(4), Asp(5), D-Phe(7), Lys(10)]-alpha-MSH(3-10) (DOTA-MSH(OCT)), which contains the metal chelator at its N-terminal end, displayed good in vitro MC1R affinity (IC(50) 9.21 nm).	Aspartic Acid	37-40	msh homeobox 1	Mus musculus	70-73
12917327-9	2003	These events are downstream of c-Jun transactivation, since GSK-3 inhibitors block neuronal death induced by constitutively active c-Jun (Ser/Thr--&gt;Asp) and FRAT1 expression inhibits AP1 reporter activity.	Aspartic Acid	151-154	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-36
12771150-2	2003	A cyclic closed-chain dodecapeptide mimicking the conformation-specific domain of CXCR4 (cDDX4) was prepared in which Gly-Asp, as the dipeptide forming a spacer arm, links the amino and carboxyl termini of the decapeptidyl linear chain (linear DDX4, Asn176 to Ile185) derived from the undecapeptidyl arch (UPA; Asn176 to Cys186) of extracellular loop 2 (ECL-2) in CXCR4.	Aspartic Acid	122-125	C-X-C motif chemokine receptor 4	Homo sapiens	82-87
12925722-0	2003	A glycine to aspartic acid substitution of COL2A1 in a family with the Strudwick variant of spondyloepimetaphyseal dysplasia.	Aspartic Acid	13-26	collagen type II alpha 1 chain	Homo sapiens	43-49
12968937-11	2003	Aspartate, glutamate, glycine, alanine and tryptophan were present at significantly higher concentrations in blastocoel fluid than in SOFaaBSA, whereas threonine and asparagine concentrations were significantly lower.	Aspartic Acid	0-9	albumin	Bos taurus	134-142
12810712-7	2003	The results show that while the interactions of the sulfuryl moiety and the phenyl ring with the YopH active site contribute to pNCS binding affinity, additional interactions of the hydroxyl and nitro groups in pNCS with Asp-356, Gln-357, Arg-404, and Gln-446 are responsible for the increased potency and selectivity.	Aspartic Acid	221-224	YopH	Yersinia pestis	97-101
12810712-8	2003	In particular, we note that residues Arg-404, Glu-290, Asp-356, and a bound water (WAT185) participate in a unique H-bonding network with the hydroxyl group ortho to the sulfuryl moiety, which may be exploited to design more potent and specific YopH inhibitors.	Aspartic Acid	55-58	YopH	Yersinia pestis	245-249
14578575-6	2003	The catalytic triad of serine proteinases of the subtilisin family was found at Asp-168, His-209, and Ser-383 in the PC1 protein and at Asp-167, His-208, and Ser-384 in the PC2 protein.	Aspartic Acid	80-83	proprotein convertase subtilisin/kexin type 1	Homo sapiens	117-120
12771150-2	2003	A cyclic closed-chain dodecapeptide mimicking the conformation-specific domain of CXCR4 (cDDX4) was prepared in which Gly-Asp, as the dipeptide forming a spacer arm, links the amino and carboxyl termini of the decapeptidyl linear chain (linear DDX4, Asn176 to Ile185) derived from the undecapeptidyl arch (UPA; Asn176 to Cys186) of extracellular loop 2 (ECL-2) in CXCR4.	Aspartic Acid	122-125	DEAD-box helicase 4	Homo sapiens	90-94
12794088-2	2003	We have investigated the role of aspartate residues Asp194-Asp195-Asp196 corresponding to the glycosyltransferase DXD signature motif, in GlcAT-I function by UDP binding experiments, kinetic analyses, and site-directed mutagenesis.	Aspartic Acid	33-42	beta-1,3-glucuronyltransferase 3	Homo sapiens	138-145
12794066-3	2003	Using a substrate-based screening assay for factor XIII activity complemented by kinetic analysis of activation peptide cleavage, we show by using thrombin mutants of surface-exposed residues that Arg-178, Arg-180, Asp-183, Glu-229, Arg-233, and Trp-50 of thrombin are necessary for direct activation of factor XIII.	Aspartic Acid	215-218	coagulation factor II, thrombin	Homo sapiens	147-155
12813041-4	2003	Here we show that Asp-331 in the carboxyl terminus of Skp2 is required for its association with Cks1 and ubiquitination of p27.	Aspartic Acid	18-21	interferon alpha inducible protein 27	Homo sapiens	123-126
12813041-4	2003	Here we show that Asp-331 in the carboxyl terminus of Skp2 is required for its association with Cks1 and ubiquitination of p27.	Aspartic Acid	18-21	S-phase kinase associated protein 2	Homo sapiens	54-58
12813041-6	2003	Although Asp-331 mutation negates the ability of the Skp1-Cullin-F-box protein (SCF) complex to ubiquitylate p27, such a mutation has no effect on Skp2 self-ubiquitination.	Aspartic Acid	9-12	S-phase kinase associated protein 1	Homo sapiens	53-57
12813041-4	2003	Here we show that Asp-331 in the carboxyl terminus of Skp2 is required for its association with Cks1 and ubiquitination of p27.	Aspartic Acid	18-21	CDC28 protein kinase regulatory subunit 1B pseudogene 7	Homo sapiens	96-100
12813041-6	2003	Although Asp-331 mutation negates the ability of the Skp1-Cullin-F-box protein (SCF) complex to ubiquitylate p27, such a mutation has no effect on Skp2 self-ubiquitination.	Aspartic Acid	9-12	KIT ligand	Homo sapiens	80-83
12813041-6	2003	Although Asp-331 mutation negates the ability of the Skp1-Cullin-F-box protein (SCF) complex to ubiquitylate p27, such a mutation has no effect on Skp2 self-ubiquitination.	Aspartic Acid	9-12	interferon alpha inducible protein 27	Homo sapiens	109-112
12899616-2	2003	Here, we show that a globular C-terminal domain of CD69 belonging to C-type lectins binds calcium through Asp 171, Glu 185, and Glu 187 with K(d) approximately 54 microM.	Aspartic Acid	106-109	CD69 molecule	Homo sapiens	51-55
12893290-6	2003	Such increases, however, were markedly or completely abolished in mutants that had a substitution (Ala, Cys, Asp, or His) on the serine residue in the GXSXG motif, providing direct evidence that NRE is a serine hydrolase.	Aspartic Acid	109-112	patatin-like phospholipase domain containing 7	Rattus norvegicus	195-198
12888622-3	2003	Here, we report that tau is proteolyzed by multiple caspases at a highly conserved aspartate residue (Asp421) in its C terminus in vitro and in neurons treated with amyloid-beta (Abeta) (1-42) peptide.	Aspartic Acid	83-92	microtubule associated protein tau	Homo sapiens	21-24
12766171-11	2003	Indeed, the transplanted lysyl-tRNA synthetase succeeds in suppressing a missense Lys --&gt; Asp mutation inserted into the beta-lactamase gene.	Aspartic Acid	93-96	lysyl-tRNA synthetase 1	Homo sapiens	25-46
12898509-7	2003	Elevated levels of BCL-2 expression results in N-terminal cleavage of BCL-2 at a novel site different from a previously identified caspase cleavage site at Asp 34 by a non-caspase protease.	Aspartic Acid	156-159	BCL2 apoptosis regulator	Homo sapiens	19-24
12898509-7	2003	Elevated levels of BCL-2 expression results in N-terminal cleavage of BCL-2 at a novel site different from a previously identified caspase cleavage site at Asp 34 by a non-caspase protease.	Aspartic Acid	156-159	BCL2 apoptosis regulator	Homo sapiens	70-75
12899615-5	2003	We suggest that the catalytic mechanism of CAD involves a conserved histidine residue, acting as a general base, and another histidine as well as an aspartic acid residue required for cofactor binding.	Aspartic Acid	149-162	DNA fragmentation factor subunit beta	Homo sapiens	43-46
12930744-8	2003	Two different glycine residues (G(102) and G(112)) are replaced by aspartic acid and both are in the unstructured region of RPL4 that lines the peptide exit tunnel of the chloroplast ribosome.	Aspartic Acid	67-80	ribosomal protein L4	Chlamydomonas reinhardtii	124-128
12878219-2	2003	Structural and functional studies have shown that the NAT1 and factor XIII transglutaminase catalytic pockets are structurally related with the existence of a conserved catalytic triad (Cys-His-Asp).	Aspartic Acid	194-197	N-acetyltransferase 1	Homo sapiens	54-58
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	73-76	dual specificity phosphatase 6	Homo sapiens	144-148
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	73-76	mitogen-activated protein kinase 1	Homo sapiens	179-183
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	73-76	dual specificity phosphatase 6	Homo sapiens	192-196
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	91-94	dual specificity phosphatase 6	Homo sapiens	144-148
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	91-94	mitogen-activated protein kinase 1	Homo sapiens	179-183
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	91-94	dual specificity phosphatase 6	Homo sapiens	192-196
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	91-94	dual specificity phosphatase 6	Homo sapiens	144-148
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	91-94	mitogen-activated protein kinase 1	Homo sapiens	179-183
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Aspartic Acid	91-94	dual specificity phosphatase 6	Homo sapiens	192-196
12740867-0	2003	Changes in NPY-mediated modulation of hippocampal [3H]D-aspartate outflow in the kindling model of epilepsy.	Aspartic Acid	56-65	neuropeptide Y	Rattus norvegicus	11-14
12869648-2	2003	It has been hypothesized that the DAT transmembrane aspartic acid residue D79 forms an ionic interaction with charged nitrogen atoms in both dopamine and cocaine.	Aspartic Acid	52-65	solute carrier family 6 member 3	Rattus norvegicus	34-37
12756249-8	2003	Further adhesion experiments demonstrated that binding of trophoblast cells to fibronectin was completely inhibited by a peptide of the Arg-Gly-Asp (RGD) sequence, which binds to integrins alpha5beta1, alphaVbeta1, alphaVbeta3, and alphaVbeta5, whereas non-binding peptide containing Arg-Gly-Glu (RGE) had minimal effects.	Aspartic Acid	144-147	fibronectin 1	Homo sapiens	79-90
12966075-4	2003	In particular, the proposed catalytic residues (Ser, Asp, and His) of AARE, called the "catalytic triad residues, " were completely conserved.	Aspartic Acid	53-56	acylaminoacyl-peptidase-like protein	Arabidopsis thaliana	70-74
12827502-6	2003	For this purpose, we constructed two alleles, din7-D78A and din7-D173A, which encode proteins in which highly conserved aspartates important for the nuclease activity of the XPG proteins have been replaced by alanines.	Aspartic Acid	120-130	exodeoxyribonuclease DIN7	Saccharomyces cerevisiae S288C	46-50
12827502-6	2003	For this purpose, we constructed two alleles, din7-D78A and din7-D173A, which encode proteins in which highly conserved aspartates important for the nuclease activity of the XPG proteins have been replaced by alanines.	Aspartic Acid	120-130	exodeoxyribonuclease DIN7	Saccharomyces cerevisiae S288C	60-64
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Aspartic Acid	282-291	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	25-29
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Aspartic Acid	282-291	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	62-66
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Aspartic Acid	282-291	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	70-73
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Aspartic Acid	302-305	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	25-29
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Aspartic Acid	302-305	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	62-66
12941880-1	2003	The Arabidopsis thaliana AHK4 histidine kinase (also known as CRE1 or WOL) acts as a cytokinin signal transducer, presumably, in concert with downstream components, such as histidine-containing phosphotransfer factors (AHPs) and response regulators (ARRs), through the histidine-to-aspartate (His--&gt;Asp) phosphorelay.	Aspartic Acid	302-305	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	70-73
12941880-6	2003	These results support the view that ARR15 acts as a repressor that mediates a negative feedback loop in the cytokinin and AHK4-mediated His--&gt;Asp phosphorelay.	Aspartic Acid	145-148	response regulator 15	Arabidopsis thaliana	36-41
12941880-6	2003	These results support the view that ARR15 acts as a repressor that mediates a negative feedback loop in the cytokinin and AHK4-mediated His--&gt;Asp phosphorelay.	Aspartic Acid	145-148	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	122-126
12890001-4	2003	This nucleotide change causes an amino acid substitution from aspartic acid in DPB1*3901 to histidine at codon 64 in the novel allele.	Aspartic Acid	62-75	major histocompatibility complex, class II, DP beta 1	Homo sapiens	79-83
12697028-7	2003	Catalytically competent IA-2 and IA-2beta species were generated by "back-mutation" of only three key residues (equivalent to Tyr(46), Asp(181) and Ala(217) using the human PTP1B numbering) to those of PTP1B.	Aspartic Acid	135-138	protein tyrosine phosphatase receptor type N	Homo sapiens	24-28
12834916-4	2003	While glutamate-induced increases in glutamine and serine were sustained for up to 24 h, increases in aspartate lasted only for up to 6 h. The glutamate-induced increases in aspartate and glutamine were dependent both on the concentration and the duration of glutamate stimulus, but were largely insensitive to the inhibition of non-N-methyl-D-aspartate receptors or the metabotropic glutamate receptor 5.	Aspartic Acid	174-183	glutamate metabotropic receptor 5	Rattus norvegicus	371-404
12895290-5	2003	A sequence analysis of the point mutants revealed that Asp-26, Met-52, and Met-78 of CKIIbeta are critical for L41 binding; Asn-67 (and/or Lys-139) and Met-52 are important for CKIIbeta homodimerization.	Aspartic Acid	55-58	casein kinase 2 beta	Homo sapiens	85-93
12895290-5	2003	A sequence analysis of the point mutants revealed that Asp-26, Met-52, and Met-78 of CKIIbeta are critical for L41 binding; Asn-67 (and/or Lys-139) and Met-52 are important for CKIIbeta homodimerization.	Aspartic Acid	55-58	ribosomal protein L41	Homo sapiens	111-114
12697028-7	2003	Catalytically competent IA-2 and IA-2beta species were generated by "back-mutation" of only three key residues (equivalent to Tyr(46), Asp(181) and Ala(217) using the human PTP1B numbering) to those of PTP1B.	Aspartic Acid	135-138	protein tyrosine phosphatase receptor type N2	Homo sapiens	33-41
12697028-10	2003	Thus molecular modelling of this classical, competitive inhibitor in the catalytic site of wild-type IA-2beta identified two residues (Ser(762) and Asp(933)) that offer the possibility for unique interaction with an appropriately modified "Compound 6 ".	Aspartic Acid	148-151	protein tyrosine phosphatase receptor type N2	Homo sapiens	101-109
12846581-2	2003	Previous work has indicated that the C-terminal region of tau inhibits polymerization in vitro, and a growing body of evidence implicates caspase cleavage of tau at Asp 421 in the C-terminus as an important inducer of tau polymerization in Alzheimer"s disease.	Aspartic Acid	165-168	microtubule associated protein tau	Homo sapiens	158-161
12846581-2	2003	Previous work has indicated that the C-terminal region of tau inhibits polymerization in vitro, and a growing body of evidence implicates caspase cleavage of tau at Asp 421 in the C-terminus as an important inducer of tau polymerization in Alzheimer"s disease.	Aspartic Acid	165-168	microtubule associated protein tau	Homo sapiens	158-161
12821118-7	2003	In vitro cleavage assays indicated that recombinant human JNK1beta2 and JNK2beta2 were cleaved by caspase-3, and that the mutation of aspartic acid at position 413 of JNK1beta2 or 410 of JNK2beta2 to alanine abolished the cleavage.	Aspartic Acid	134-147	caspase 3	Homo sapiens	98-107
12821118-7	2003	In vitro cleavage assays indicated that recombinant human JNK1beta2 and JNK2beta2 were cleaved by caspase-3, and that the mutation of aspartic acid at position 413 of JNK1beta2 or 410 of JNK2beta2 to alanine abolished the cleavage.	Aspartic Acid	134-147	mitogen-activated protein kinase 9	Homo sapiens	72-80
12832058-1	2003	The interaction of the CXCR4 antagonist AMD3100 with its target is greatly influenced by specific aspartate residues in the receptor protein, including Asp(171) and Asp(262).	Aspartic Acid	98-107	C-X-C motif chemokine receptor 4	Homo sapiens	23-28
12707275-11	2003	These results highlight the crucial role played by Asp-742 in the architecture of the hSPCA1 ion-binding site and reveal a role for Gly-309 in Mn2+ transport selectivity.	Aspartic Acid	51-54	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	86-92
12832058-1	2003	The interaction of the CXCR4 antagonist AMD3100 with its target is greatly influenced by specific aspartate residues in the receptor protein, including Asp(171) and Asp(262).	Aspartic Acid	152-155	C-X-C motif chemokine receptor 4	Homo sapiens	23-28
12832058-1	2003	The interaction of the CXCR4 antagonist AMD3100 with its target is greatly influenced by specific aspartate residues in the receptor protein, including Asp(171) and Asp(262).	Aspartic Acid	165-168	C-X-C motif chemokine receptor 4	Homo sapiens	23-28
12832058-2	2003	We have now found that aspartate-to-asparagine substitutions at these positions differentially affect the binding of four different anti-CXCR4 monoclonal antibodies as well as the infectivity of diverse human immunodeficiency virus type 1 (HIV-1) strains and clinical isolates.	Aspartic Acid	23-32	C-X-C motif chemokine receptor 4	Homo sapiens	137-142
12832058-3	2003	Mutation of Asp(262) strongly decreased the coreceptor efficiency of CXCR4 for wild-type but not for AMD3100-resistant HIV-1 NL4.3.	Aspartic Acid	12-15	C-X-C motif chemokine receptor 4	Homo sapiens	69-74
12832058-4	2003	Thus, resistance of HIV-1 NL4.3 to AMD3100 is associated with a decreased dependence of the viral gp120 on Asp(262) of CXCR4, pointing to a different mode of interaction of wild-type versus AMD3100-resistant virus with CXCR4.	Aspartic Acid	107-110	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	98-103
12832058-4	2003	Thus, resistance of HIV-1 NL4.3 to AMD3100 is associated with a decreased dependence of the viral gp120 on Asp(262) of CXCR4, pointing to a different mode of interaction of wild-type versus AMD3100-resistant virus with CXCR4.	Aspartic Acid	107-110	C-X-C motif chemokine receptor 4	Homo sapiens	119-124
12853981-4	2003	We report a G&gt;T transversion mutation in the last nucleotide of exon 2, affecting the aspartic acid residue at position 153 of CDKN2A-p16(INK4a) in a proband with melanoma.	Aspartic Acid	89-102	cyclin dependent kinase inhibitor 2A	Homo sapiens	130-136
12853981-4	2003	We report a G&gt;T transversion mutation in the last nucleotide of exon 2, affecting the aspartic acid residue at position 153 of CDKN2A-p16(INK4a) in a proband with melanoma.	Aspartic Acid	89-102	cyclin dependent kinase inhibitor 2A	Homo sapiens	137-140
12853981-4	2003	We report a G&gt;T transversion mutation in the last nucleotide of exon 2, affecting the aspartic acid residue at position 153 of CDKN2A-p16(INK4a) in a proband with melanoma.	Aspartic Acid	89-102	cyclin dependent kinase inhibitor 2A	Homo sapiens	141-146
12821135-5	2003	HCT116 p53-/- cells expressing p53 mutant, in which serine residues at 6, 9, 46, 376, and 378 were replaced by aspartic acids, were resistant to TPCK-induced apoptosis suggesting the requirement of dephosphorylation of p53 on serine residues during TPCK-induced apoptosis.	Aspartic Acid	111-125	tumor protein p53	Homo sapiens	31-34
12821135-5	2003	HCT116 p53-/- cells expressing p53 mutant, in which serine residues at 6, 9, 46, 376, and 378 were replaced by aspartic acids, were resistant to TPCK-induced apoptosis suggesting the requirement of dephosphorylation of p53 on serine residues during TPCK-induced apoptosis.	Aspartic Acid	111-125	tumor protein p53	Homo sapiens	31-34
12821136-7	2003	The results thus indicate that this mutation causes constitutive receptor-G(i)-protein precoupling, and that the D(3.49) aspartate residue of the DRY motif is involved in controlling coupled and uncoupled conformations of alpha(2B)-AR.	Aspartic Acid	121-130	adrenoceptor alpha 2B	Homo sapiens	222-234
12832612-7	2003	One variant, Asp-49-Arg-42-Arg-45-eglin, exhibited a Ki of 310 pM for furin and blocked furin-dependent processing of von Willebrand factor in COS-1 cells when added to the culture medium of the cells.	Aspartic Acid	13-16	furin, paired basic amino acid cleaving enzyme	Homo sapiens	70-75
12832612-7	2003	One variant, Asp-49-Arg-42-Arg-45-eglin, exhibited a Ki of 310 pM for furin and blocked furin-dependent processing of von Willebrand factor in COS-1 cells when added to the culture medium of the cells.	Aspartic Acid	13-16	furin, paired basic amino acid cleaving enzyme	Homo sapiens	88-93
12682056-5	2003	A mutagenesis study on the K+ binding side chains showed that Asn-13 and Asp-65 are essential for potassium binding, but the impact on the stability of ArsC was the most extreme when mutating Ser-36.	Aspartic Acid	73-76	Arsenate reductase	Staphylococcus aureus	152-156
12818574-6	2003	After 15-min ischemia and reperfusion, a 15-kDa MLC-2 fragment was detected (MLC-2(14-165)), resulting from N-terminal cleavage between Asn/Asp-13 and Ser-14 of non-phosphorylated MLC-2, which accounted for 9.8% of visible non-phosphorylated MLC-2.	Aspartic Acid	140-143	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	48-53
12678920-5	2003	PHEX showed a strict requirement for acidic amino acid residues (aspartate or glutamate) in S(1)" subsite, with a strong preference for aspartate.	Aspartic Acid	65-74	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	0-4
12678920-5	2003	PHEX showed a strict requirement for acidic amino acid residues (aspartate or glutamate) in S(1)" subsite, with a strong preference for aspartate.	Aspartic Acid	136-145	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	0-4
12678920-7	2003	The peptide Abz-GFSDYK(Dnp)-OH, which contains the most favourable residues in the P(2) to P(2)" positions, was hydrolysed by PHEX at the N-terminus of aspartate with a k(cat)/ K(m) of 167 mM(-1) x s(-1).	Aspartic Acid	152-161	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	126-130
12649162-6	2003	The second patient was homozygous for an in-frame deletion (GAC) from nucleotide (nt) 498 to 500 or nt 501 to 503 of the cDNA sequence, predicting deletion of either aspartic acid (Asp) 140 or 141.	Aspartic Acid	166-179	glutaminase	Homo sapiens	60-63
12649162-6	2003	The second patient was homozygous for an in-frame deletion (GAC) from nucleotide (nt) 498 to 500 or nt 501 to 503 of the cDNA sequence, predicting deletion of either aspartic acid (Asp) 140 or 141.	Aspartic Acid	181-184	glutaminase	Homo sapiens	60-63
12884396-2	2003	An amino acid sequence of the peptide used for impregnation was derived from the III transmembrane segment of the 5-HT(1A) receptor in the close vicinity of aspartic acid (Asp 166) residue.	Aspartic Acid	157-170	5-hydroxytryptamine receptor 1A	Homo sapiens	114-131
12884396-2	2003	An amino acid sequence of the peptide used for impregnation was derived from the III transmembrane segment of the 5-HT(1A) receptor in the close vicinity of aspartic acid (Asp 166) residue.	Aspartic Acid	172-175	5-hydroxytryptamine receptor 1A	Homo sapiens	114-131
12721840-9	2003	The tertiary structural model of the GALNS protein revealed that aspartic acid at position 60 is located on the surface of the molecule, away from the active site.	Aspartic Acid	65-78	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	37-42
12775683-3	2003	The Gly-240-harbouring enzyme CTX-M-27 conferred to E. coli higher MICs of ceftazidime (MIC, 8 versus 1 mg/L) than did the Asp-240-harbouring CTX-M-14 enzyme.	Aspartic Acid	123-126	CTX-M-14	Escherichia coli	142-150
12817189-3	2003	METHODS AND RESULTS: In rat isolated kidney Ang I, Ang II, Ang III, Ang IV and des-Asp-Ang I induced pressor responses and enhanced noradrenaline release to renal nerve stimulation (RNS) in an concentration-dependent manner, with the following rank order of potency (EC(50)): Ang II &gt;or= Ang III &gt; Ang I = des-Asp-Ang I &gt; Ang IV.	Aspartic Acid	316-319	angiotensinogen	Rattus norvegicus	51-57
12817189-3	2003	METHODS AND RESULTS: In rat isolated kidney Ang I, Ang II, Ang III, Ang IV and des-Asp-Ang I induced pressor responses and enhanced noradrenaline release to renal nerve stimulation (RNS) in an concentration-dependent manner, with the following rank order of potency (EC(50)): Ang II &gt;or= Ang III &gt; Ang I = des-Asp-Ang I &gt; Ang IV.	Aspartic Acid	316-319	angiotensinogen	Rattus norvegicus	59-65
12817189-10	2003	In the case of Ang I and des-Asp-Ang I this depends on conversion by ACE.	Aspartic Acid	29-32	angiotensin I converting enzyme	Rattus norvegicus	69-72
12818574-6	2003	After 15-min ischemia and reperfusion, a 15-kDa MLC-2 fragment was detected (MLC-2(14-165)), resulting from N-terminal cleavage between Asn/Asp-13 and Ser-14 of non-phosphorylated MLC-2, which accounted for 9.8% of visible non-phosphorylated MLC-2.	Aspartic Acid	140-143	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	77-82
12818574-6	2003	After 15-min ischemia and reperfusion, a 15-kDa MLC-2 fragment was detected (MLC-2(14-165)), resulting from N-terminal cleavage between Asn/Asp-13 and Ser-14 of non-phosphorylated MLC-2, which accounted for 9.8% of visible non-phosphorylated MLC-2.	Aspartic Acid	140-143	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	77-82
12818574-6	2003	After 15-min ischemia and reperfusion, a 15-kDa MLC-2 fragment was detected (MLC-2(14-165)), resulting from N-terminal cleavage between Asn/Asp-13 and Ser-14 of non-phosphorylated MLC-2, which accounted for 9.8% of visible non-phosphorylated MLC-2.	Aspartic Acid	140-143	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	77-82
12679340-5	2003	In OTCase, mutations of putative ornithine binding residues, Asp-182, Asn-184, Asn-185, Cys-289, and Glu-256 greatly reduced the affinity for ornithine and impaired the interaction with arginase.	Aspartic Acid	61-64	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	3-9
12857817-10	2003	Specific amino acids within the AtCNGC2 pore selectivity filter (Asn-416, Asp-417) are demonstrated to facilitate K(+) over Na(+) conductance.	Aspartic Acid	74-77	Cyclic nucleotide-regulated ion channel family protein	Arabidopsis thaliana	32-39
12660235-3	2003	To investigate the role of particular residues in ligand binding of the serotonin 5-HT3AS receptor (5-HT3R), glutamate amino acid residues at three different positions, Glu97, Glu224, and Glu235, in the extracellular N-terminal domain were substituted with aspartate and glutamine using site-directed mutagenesis.	Aspartic Acid	257-266	5-hydroxytryptamine receptor 3A	Homo sapiens	100-106
12840230-10	2003	The DING protein (N-terminal amino acid sequence Asp-Ile-Asn-Gly) that binds to genistein with high affinity is one of these.	Aspartic Acid	49-52	ring finger protein 2	Homo sapiens	4-8
12824482-3	2003	For aminergic GPCRs, the motif is composed of a conserved aspartic acid in the third transmembrane (TM) domain (rhodopsin position 117) and a conserved tryptophan in the seventh TM domain (rhodopsin position 293); the roles of each are readily justified by molecular modeling of ligand-receptor interactions.	Aspartic Acid	58-71	rhodopsin	Homo sapiens	112-121
12795600-0	2003	Surface salt bridges, double-mutant cycles, and protein stability: an experimental and computational analysis of the interaction of the Asp 23 side chain with the N-terminus of the N-terminal domain of the ribosomal protein l9.	Aspartic Acid	136-139	ribosomal protein L9	Homo sapiens	206-226
12779324-0	2003	The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad.	Aspartic Acid	114-117	Patatin-2-Kuras 1	Solanum tuberosum	69-76
12763579-1	2003	Aralar1 and citrin are two isoforms of the mitochondrial carrier of aspartate-glutamate (AGC), a calcium regulated carrier, which is important in the malate-aspartate NADH shuttle.	Aspartic Acid	68-77	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	12-18
12888330-3	2003	We assessed whether TNF gene polymorphism and plasma concentrations of TNF-alpha were related to the occurrence of ASP and septic shock from it.	Aspartic Acid	115-118	tumor necrosis factor	Homo sapiens	20-23
12888330-3	2003	We assessed whether TNF gene polymorphism and plasma concentrations of TNF-alpha were related to the occurrence of ASP and septic shock from it.	Aspartic Acid	115-118	tumor necrosis factor	Homo sapiens	71-80
12779324-4	2003	The structure notably revealed that patatin has a Ser-Asp catalytic dyad and an active site like that of human cytosolic phospholipase A(2) (cPLA(2)) [Dessen, A., et al.	Aspartic Acid	54-57	Patatin-2-Kuras 1	Solanum tuberosum	36-43
12888330-14	2003	CONCLUSIONS: Results indicate that the TNF gene polymorphisms studied play no part in determination of disease severity or ASP susceptibility; however, they are both strongly related to the development of septic shock in ASP.	Aspartic Acid	221-224	tumor necrosis factor	Homo sapiens	39-42
12779324-7	2003	The structure confirms our site-directed mutagenesis and bioactivity data that initially suggested patatin possessed a Ser-Asp catalytic dyad.	Aspartic Acid	123-126	Patatin-2-Kuras 1	Solanum tuberosum	99-106
12771194-6	2003	On the other hand, all five aspartates work in a concerted fashion in contributing to the slow deactivation process of the HERG channel.	Aspartic Acid	28-38	potassium voltage-gated channel subfamily H member 2	Homo sapiens	123-127
12778490-3	2003	We observed, for clone F1-9, that a substitution of aspartic acid for asparagine in the core region of the epitope increased the stimulatory capacity of the peptide about 100-fold in comparison with the natural peptide.	Aspartic Acid	52-65	coagulation factor II, thrombin	Homo sapiens	23-27
12743166-2	2003	The mutations of the aspartate residues to glutamate induce changes in the conduction properties, enhance Cd2+ and proton affinities, and modify the activation curve of the channel.	Aspartic Acid	21-30	CD2 molecule	Homo sapiens	106-109
12734658-8	2003	In the second case, in tumor samples from one hemisphere, nuclear accumulation of p53 was caused by a G--&gt;A transition in codon 244 (Gly--&gt;Asp).	Aspartic Acid	145-148	tumor protein p53	Homo sapiens	82-85
12790809-4	2003	However, replacement of a conserved tyrosine residue in Helix 12 with alanine or aspartate (Y541A and Y541D), which renders ERalpha constitutively active in mammalian cells, had only a weak stimulatory effect on ligand-independent reporter activation by ERalpha in yeast.	Aspartic Acid	81-90	estrogen receptor 1	Homo sapiens	124-131
12788385-1	2003	In pressure-overloaded myocardium, our recent study demonstrated cytoskeletal assembly of c-Src and other signaling proteins which was partially mimicked in vitro using adult feline cardiomyocytes embedded in three-dimensional (3D) collagen matrix and stimulated with an integrin-binding Arg-Gly-Asp (RGD) peptide.	Aspartic Acid	296-299	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
12790809-4	2003	However, replacement of a conserved tyrosine residue in Helix 12 with alanine or aspartate (Y541A and Y541D), which renders ERalpha constitutively active in mammalian cells, had only a weak stimulatory effect on ligand-independent reporter activation by ERalpha in yeast.	Aspartic Acid	81-90	estrogen receptor 1	Homo sapiens	254-261
12753897-3	2003	However, the substitution of the serine residues with the aspartic acid (S116/127D) abolished p53 DNA binding and led to protein stabilization.	Aspartic Acid	58-71	tumor protein p53	Homo sapiens	94-97
12953792-7	2003	Mutations D71N, D73N, and D100N reduced kcat markedly, indicating that these aspartic acids play a crucial role in carrying out the catalytic process of hTPK1.	Aspartic Acid	77-91	thiamin pyrophosphokinase 1	Homo sapiens	153-158
12758078-0	2003	Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1.	Aspartic Acid	43-52	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	113-117
12758078-4	2003	Here, we apply liquid-state NMR to investigate the role of a critical histidine residue of apurinic endonuclease 1 (Ape1), a human DNA repair enzyme that cleaves adjacent to abasic sites in DNA using one or more divalent cations and an active-site His-Asp pair.	Aspartic Acid	252-255	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	91-114
12758078-4	2003	Here, we apply liquid-state NMR to investigate the role of a critical histidine residue of apurinic endonuclease 1 (Ape1), a human DNA repair enzyme that cleaves adjacent to abasic sites in DNA using one or more divalent cations and an active-site His-Asp pair.	Aspartic Acid	252-255	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	116-120
12758078-5	2003	The results of these studies suggest that the Ape1 His-Asp pair does not function as either a general base catalyst or a metal ligand.	Aspartic Acid	55-58	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	46-50
12749910-4	2003	By deletion and mutation analysis we show that the SPI-C protein has a transactivation domain located to the N-terminus, and that the transactivation activity is reduced to that of the DNA binding domain (DBD) alone when four aspartic acid residues are mutated to alanines.	Aspartic Acid	226-239	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	51-56
12795375-5	2003	Mutant variants altered in aspartate residues within the loop region of p35 are inefficient substrates for caspases in vitro, and they do not suppress caspase proteolytic activity in animal systems.	Aspartic Acid	27-36	interleukin 12A	Homo sapiens	72-75
12755614-4	2003	The alpha(2)M-derived peptides are notable for hydrophobic tripeptide sequences (WIW or VVV) and acidic residues (Glu(714) and Asp(719) in the mature alpha(2)M subunit), which may function analogously to the structural elements that mediate TGF-beta-binding in the type II receptor.	Aspartic Acid	127-130	alpha-2-macroglobulin	Homo sapiens	4-13
12755614-4	2003	The alpha(2)M-derived peptides are notable for hydrophobic tripeptide sequences (WIW or VVV) and acidic residues (Glu(714) and Asp(719) in the mature alpha(2)M subunit), which may function analogously to the structural elements that mediate TGF-beta-binding in the type II receptor.	Aspartic Acid	127-130	alpha-2-macroglobulin	Homo sapiens	150-159
12755614-5	2003	Mutating Glu(714) and Asp(719) in the alpha(2)M-peptide-GST fusion protein, FP3, which contains the putative growth factor-binding site, significantly decreased the binding affinity of FP3 for TGF-beta1.	Aspartic Acid	22-25	alpha-2-macroglobulin	Homo sapiens	38-47
12755614-5	2003	Mutating Glu(714) and Asp(719) in the alpha(2)M-peptide-GST fusion protein, FP3, which contains the putative growth factor-binding site, significantly decreased the binding affinity of FP3 for TGF-beta1.	Aspartic Acid	22-25	transforming growth factor beta 1	Homo sapiens	193-202
12926277-1	2003	The synthesis of a Tentagel-supported peptide incorporating the reactive triad of serine, histidine and aspartic acid, found within serine protease enzymes, is described.	Aspartic Acid	104-117	coagulation factor II, thrombin	Homo sapiens	132-147
12547830-2	2003	Recently, we noticed the ends of loop E-2 are linked by an ion pair between residues Arg-177 and Asp-190, near the highly conserved disulfide bond.	Aspartic Acid	97-100	cystatin 12, pseudogene	Homo sapiens	38-41
12547830-8	2003	Our results indicate that the loop E-2 ion pair is important for rhodopsin stability and thus suggest that retinitis pigmentosa observed in patients with Asp-190 mutations may in part be the result of thermally unstable rhodopsin proteins.	Aspartic Acid	154-157	cystatin 12, pseudogene	Homo sapiens	35-38
12547830-8	2003	Our results indicate that the loop E-2 ion pair is important for rhodopsin stability and thus suggest that retinitis pigmentosa observed in patients with Asp-190 mutations may in part be the result of thermally unstable rhodopsin proteins.	Aspartic Acid	154-157	rhodopsin	Homo sapiens	65-74
12547830-8	2003	Our results indicate that the loop E-2 ion pair is important for rhodopsin stability and thus suggest that retinitis pigmentosa observed in patients with Asp-190 mutations may in part be the result of thermally unstable rhodopsin proteins.	Aspartic Acid	154-157	rhodopsin	Homo sapiens	220-229
12591933-7	2003	Inspection of the corresponding S(2) pocket of the substrate-binding cleft of the protease reveals that MMP-9 contains an Asp, whereas MMP-2 contains Glu.	Aspartic Acid	122-125	matrix metallopeptidase 9	Homo sapiens	104-109
12591933-9	2003	Mutation of Glu(412) in MMP-2 to Asp significantly reduced the hydrolysis of selective substrates, with only a minor effect on hydrolysis of non-selective substrates.	Aspartic Acid	33-36	matrix metallopeptidase 2	Homo sapiens	24-29
12591923-8	2003	STAT1 preferentially binds peptides with the motif phosphotyrosine-(aspartic acid/glutamic acid)-(proline/arginine)-(arginine/proline/glutamine), whereby a negatively charged amino acid at +1 excludes a proline at +2 and vice versa.	Aspartic Acid	68-81	signal transducer and activator of transcription 1	Mus musculus	0-5
12606538-7	2003	Distinguishing features, such as a short "aspartate loop" at the active site, suggest however that Ssu72 is the founding member of a new phosphatase subfamily.	Aspartic Acid	42-51	SSU72 homolog, RNA polymerase II CTD phosphatase	Homo sapiens	99-104
12598529-1	2003	Bid is instrumental in death receptor-mediated apoptosis where it is cleaved by caspase 8 at aspartate 60 and aspartate 75 to generate truncated Bid (tBID) forms that facilitate release of mitochondrial cytochrome c. Bid is also cleaved at these sites by caspase 3 that is activated downstream of cytochrome c release after diverse apoptotic stimuli.	Aspartic Acid	93-102	BH3 interacting domain death agonist	Mus musculus	0-3
12598529-1	2003	Bid is instrumental in death receptor-mediated apoptosis where it is cleaved by caspase 8 at aspartate 60 and aspartate 75 to generate truncated Bid (tBID) forms that facilitate release of mitochondrial cytochrome c. Bid is also cleaved at these sites by caspase 3 that is activated downstream of cytochrome c release after diverse apoptotic stimuli.	Aspartic Acid	93-102	caspase 8	Mus musculus	80-89
12598529-1	2003	Bid is instrumental in death receptor-mediated apoptosis where it is cleaved by caspase 8 at aspartate 60 and aspartate 75 to generate truncated Bid (tBID) forms that facilitate release of mitochondrial cytochrome c. Bid is also cleaved at these sites by caspase 3 that is activated downstream of cytochrome c release after diverse apoptotic stimuli.	Aspartic Acid	110-119	BH3 interacting domain death agonist	Mus musculus	0-3
12598529-1	2003	Bid is instrumental in death receptor-mediated apoptosis where it is cleaved by caspase 8 at aspartate 60 and aspartate 75 to generate truncated Bid (tBID) forms that facilitate release of mitochondrial cytochrome c. Bid is also cleaved at these sites by caspase 3 that is activated downstream of cytochrome c release after diverse apoptotic stimuli.	Aspartic Acid	110-119	caspase 3	Mus musculus	255-264
12598529-1	2003	Bid is instrumental in death receptor-mediated apoptosis where it is cleaved by caspase 8 at aspartate 60 and aspartate 75 to generate truncated Bid (tBID) forms that facilitate release of mitochondrial cytochrome c. Bid is also cleaved at these sites by caspase 3 that is activated downstream of cytochrome c release after diverse apoptotic stimuli.	Aspartic Acid	93-102	caspase 3	Mus musculus	255-264
12750905-4	2003	The calculated Mr of VASAP-60 derived from its cDNA (60.1 kDa) was significantly lower than its Mr estimated by SDS-PAGE, and this was mainly attributed to the glutamic acid- and aspartic acid-rich composition of its central region (A(246) to S(418)).	Aspartic Acid	179-192	protein kinase C substrate 80K-H	Bos taurus	21-29
12709047-1	2003	Argininosuccinate synthetase (ASS, EC 6.3.4.5) catalyses the condensation of citrulline and aspartate to form argininosuccinate, the immediate precursor of arginine.	Aspartic Acid	92-101	argininosuccinate synthase 1	Homo sapiens	0-28
12709047-1	2003	Argininosuccinate synthetase (ASS, EC 6.3.4.5) catalyses the condensation of citrulline and aspartate to form argininosuccinate, the immediate precursor of arginine.	Aspartic Acid	92-101	argininosuccinate synthase 1	Homo sapiens	30-33
12750345-5	2003	We identified the VIP3 gene by positional cloning and found that it encodes a protein consisting almost exclusively of repeated Trp-Asp (WD) motifs, suggesting that VIP3 could act as a platform to assemble a protein complex.	Aspartic Acid	132-135	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	18-22
12750345-5	2003	We identified the VIP3 gene by positional cloning and found that it encodes a protein consisting almost exclusively of repeated Trp-Asp (WD) motifs, suggesting that VIP3 could act as a platform to assemble a protein complex.	Aspartic Acid	132-135	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	165-169
12746911-3	2003	The third exon of the B27 gene was analyzed for the presence of Asp(116) or His(116), which differentiates B*2709 from the other two B27 subtypes (B*2705 and B*2702) that are mostly found in Sardinia.	Aspartic Acid	64-67	melanocortin 2 receptor accessory protein	Homo sapiens	22-25
12707374-5	2003	The second type of FLT3 mutation, missense mutations at aspartic acid residue 835, occurs in approximately 7.0% of acute myelogenous leukemia cases.	Aspartic Acid	56-69	fms related receptor tyrosine kinase 3	Homo sapiens	19-23
12713872-1	2003	BACKGROUND: Aspartyl (asparaginyl) beta-hydroxylase (AAH) is an alpha-ketoglutarate-dependent dioxygenase that hydroxylates aspartate and asparagine residues in EGF-like domains of proteins.	Aspartic Acid	124-133	aspartate beta-hydroxylase	Homo sapiens	12-51
12713872-1	2003	BACKGROUND: Aspartyl (asparaginyl) beta-hydroxylase (AAH) is an alpha-ketoglutarate-dependent dioxygenase that hydroxylates aspartate and asparagine residues in EGF-like domains of proteins.	Aspartic Acid	124-133	aspartate beta-hydroxylase	Homo sapiens	53-56
12576487-9	2003	Together, we provide new evidence for a critical role of aspartic acid 152, tyrosine 200, and serine 201 of the GHR contact interface in the GH-induced conformational change to a signaling-competent complex rather than in GHR dimerization.	Aspartic Acid	57-70	growth hormone receptor	Oryctolagus cuniculus	112-115
12853038-7	2003	Zebrafish MT-MMPbeta is unique among vertebrate MT-MMPs in that it contains an Arg-Glu-Asp (RED) multiple-repeat motif in its linker region.	Aspartic Acid	87-90	matrix metallopeptidase 14b (membrane-inserted)	Danio rerio	10-20
12588872-9	2003	Strikingly, however, although meizothrombins modified by substitution of Asp(554) with either Ala or Leu or by deletion of loop-2 had 6-8 and &lt;1%, respectively, of the clotting activity of alpha-thrombin, the activity of these meizothrombins for protein C was increased to &gt;10 times that of alpha-thrombin.	Aspartic Acid	73-76	coagulation factor II, thrombin	Homo sapiens	35-43
12717265-3	2003	AIMTo determine the predictive value of plasma levels of TNF-alpha and its soluble receptors (sTNFR), TNF-alpha-308 and TNFB polymorphisms on the occurrence of ASP and ASP-associated early septic shock.	Aspartic Acid	168-171	lymphotoxin alpha	Homo sapiens	120-124
12717265-3	2003	AIMTo determine the predictive value of plasma levels of TNF-alpha and its soluble receptors (sTNFR), TNF-alpha-308 and TNFB polymorphisms on the occurrence of ASP and ASP-associated early septic shock.	Aspartic Acid	160-163	tumor necrosis factor	Homo sapiens	57-66
12717265-3	2003	AIMTo determine the predictive value of plasma levels of TNF-alpha and its soluble receptors (sTNFR), TNF-alpha-308 and TNFB polymorphisms on the occurrence of ASP and ASP-associated early septic shock.	Aspartic Acid	160-163	lymphotoxin alpha	Homo sapiens	120-124
12717265-3	2003	AIMTo determine the predictive value of plasma levels of TNF-alpha and its soluble receptors (sTNFR), TNF-alpha-308 and TNFB polymorphisms on the occurrence of ASP and ASP-associated early septic shock.	Aspartic Acid	168-171	tumor necrosis factor	Homo sapiens	57-66
12473655-8	2003	The mass spectra for the Asp(131)-Arg(153) peptides from the oxidized and reduced forms of human RNase H1 in the presence and absence of NEM showed peptide masses consistent with the formation of a disulfide bond between Cys(147) and Cys(148).	Aspartic Acid	25-28	ribonuclease H1	Homo sapiens	97-105
12582165-5	2003	However, we were able to develop an efficient trapping mutant of SHP2 by introducing Asp to Ala and Cys to Ser double mutations.	Aspartic Acid	85-88	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	65-69
12697335-5	2003	L. japonicus squalene synthase has an unusual Asp residue near the active site, where mammalian enzymes have Gln, and replacement of the Gln by Glu has been reported to cause severe inactivation.	Aspartic Acid	46-49	LjSqS	Lotus japonicus	13-30
12680769-11	2003	S4 of Csp2, -3, and -7 represents an opposite group with a conformation that is highly specific in binding an Asp.	Aspartic Acid	110-113	regulator of calcineurin 2	Homo sapiens	6-10
12784643-0	2003	Requirement of negative residues, Asp 95 and Asp 105, in S2 on membrane integration of a voltage-dependent K+ channel, KAT1.	Aspartic Acid	34-37	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	119-123
12662928-5	2003	An aspartate residue, from the CDR3 loop of the antibody heavy chain, coordinates the MIDAS metal ion in a manner similar to that of a glutamate residue from collagen.	Aspartic Acid	3-12	CDR3	Homo sapiens	31-35
12547827-7	2003	Our data further suggest that potent, yet highly selective, PTP1B inhibitory agents can be acquired by targeting the area defined by residues Lys-41, Arg-47, and Asp-48, in addition to the previously identified second aryl phosphate-binding pocket.	Aspartic Acid	162-165	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	60-65
12551903-9	2003	Molecular modeling of apoB predicted that Arg(463) was in close proximity to Glu(756) and Asp(456).	Aspartic Acid	90-93	apolipoprotein B	Homo sapiens	22-26
12560341-7	2003	In further support of the notion that phosphorylation inhibits nuclear import, the nuclear localization signal of CDH1 with two phospho-accepting serine/threonine residues changed into aspartates was unable to drive heterologous protein into the nucleus.	Aspartic Acid	185-195	cadherin 1	Homo sapiens	114-118
12784643-0	2003	Requirement of negative residues, Asp 95 and Asp 105, in S2 on membrane integration of a voltage-dependent K+ channel, KAT1.	Aspartic Acid	45-48	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	119-123
12671900-3	2003	Mutational analysis in our patient showed a heterozygous missense mutation of the MDR3 gene that has not been described previously, which occurs in exon 14 at codon 535, and results in the substitution of glycine for aspartic acid.	Aspartic Acid	217-230	ATP binding cassette subfamily B member 4	Homo sapiens	82-86
12639933-4	2003	Binding of glomerulosa cells to fibronectin, but not to collagen I or poly-L-lysine, involved the integrin-binding sequence Arg-Gly-Asp (RGD).	Aspartic Acid	132-135	fibronectin 1	Rattus norvegicus	32-43
12639947-6	2003	The results showed that IGF-I could stimulate EVT cell migration in a time- and dose-dependent manner and addition of alphaIR3, Arg-Gly-Asp hexapeptide, and antibody against alpha(v)beta(3) integrin attenuated the IGF-I migratory effect.	Aspartic Acid	136-139	insulin like growth factor 1	Homo sapiens	24-29
12690506-0	2003	Age estimation based on aspartic acid racemization in elastin from the yellow ligaments.	Aspartic Acid	24-37	elastin	Homo sapiens	54-61
12943190-1	2003	The sequence of human urotensin II (UII) has been recently established as H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH, and it has been reported that UII is the most potent mammalian vasoconstrictor peptide identified so far.	Aspartic Acid	88-91	urotensin 2	Homo sapiens	22-40
12943190-1	2003	The sequence of human urotensin II (UII) has been recently established as H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH, and it has been reported that UII is the most potent mammalian vasoconstrictor peptide identified so far.	Aspartic Acid	88-91	urotensin 2	Homo sapiens	36-39
12671081-4	2003	The dramatic increase in free Lys in the knockout mutant expressing the bacterial DHPS was associated with a significant reduction in the levels of Glu and Asp but also with an unexpected increase in the levels of Gln and Asn.	Aspartic Acid	156-159	dihydrodipicolinate synthase 1	Arabidopsis thaliana	82-86
12660222-5	2003	The caspase-3 and caspase-9 inhibitors Z-Asp(OCH(3))-Glu(OCH(3))-Val-Asp(OCH(3))-fluoromethylketone (FMK) and Z-Leu-Glu(OCH(3))-His-Asp(OCH(3))-FMK reduced apoptotic bodies to 25-30% of the control cells.	Aspartic Acid	41-44	caspase 3	Homo sapiens	4-13
12660222-5	2003	The caspase-3 and caspase-9 inhibitors Z-Asp(OCH(3))-Glu(OCH(3))-Val-Asp(OCH(3))-fluoromethylketone (FMK) and Z-Leu-Glu(OCH(3))-His-Asp(OCH(3))-FMK reduced apoptotic bodies to 25-30% of the control cells.	Aspartic Acid	41-44	caspase 9	Homo sapiens	18-27
12660222-5	2003	The caspase-3 and caspase-9 inhibitors Z-Asp(OCH(3))-Glu(OCH(3))-Val-Asp(OCH(3))-fluoromethylketone (FMK) and Z-Leu-Glu(OCH(3))-His-Asp(OCH(3))-FMK reduced apoptotic bodies to 25-30% of the control cells.	Aspartic Acid	69-72	caspase 3	Homo sapiens	4-13
12660222-5	2003	The caspase-3 and caspase-9 inhibitors Z-Asp(OCH(3))-Glu(OCH(3))-Val-Asp(OCH(3))-fluoromethylketone (FMK) and Z-Leu-Glu(OCH(3))-His-Asp(OCH(3))-FMK reduced apoptotic bodies to 25-30% of the control cells.	Aspartic Acid	69-72	caspase 9	Homo sapiens	18-27
12529357-4	2003	The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor.	Aspartic Acid	39-42	plasminogen activator, urokinase	Gallus gallus	34-37
12812052-14	2003	The sequencing results showed that there was one single nucleotide mutation: A--&gt;G at cDNA 152 of GDF9 gene in sheep, and this mutation resulted in an amino acid change: asparagine--&gt;aspartic acid.	Aspartic Acid	189-202	growth/differentiation factor 9	Ovis aries	101-105
12529357-4	2003	The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor.	Aspartic Acid	39-42	vascular endothelial growth factor A	Gallus gallus	150-184
12540846-6	2003	C3a des-Arg(77)/ASP and C3a can potently stimulate triglyceride synthesis in human skin fibroblasts and 3T3-L1 preadipocytes.	Aspartic Acid	16-19	complement C3	Homo sapiens	0-3
12540846-8	2003	This is the first demonstration of the expression of C5L2 in cells that bind and respond to C3a des-Arg(77)/ASP and C3a.	Aspartic Acid	108-111	complement C5a receptor 2	Homo sapiens	53-57
12540846-8	2003	This is the first demonstration of the expression of C5L2 in cells that bind and respond to C3a des-Arg(77)/ASP and C3a.	Aspartic Acid	108-111	complement C3	Homo sapiens	92-95
12540846-9	2003	Thus C5L2, a promiscuous complement fragment-binding protein with a high affinity site that binds C3a des-Arg(77)/ASP, may mediate the acylation-stimulating properties of this peptide.	Aspartic Acid	114-117	complement C5a receptor 2	Homo sapiens	5-9
12540846-4	2003	Here we demonstrate that C5L2 binds the metabolites of C4a and C3a, C4a des-Arg(77), and C3a des-Arg(77) (also known as the acylation-stimulating protein or ASP) at a site distinct from the C5a binding site.	Aspartic Acid	157-160	complement C5a receptor 2	Homo sapiens	25-29
12540846-9	2003	Thus C5L2, a promiscuous complement fragment-binding protein with a high affinity site that binds C3a des-Arg(77)/ASP, may mediate the acylation-stimulating properties of this peptide.	Aspartic Acid	114-117	complement C3	Homo sapiens	98-101
12529357-4	2003	The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor.	Aspartic Acid	39-42	vascular endothelial growth factor A	Gallus gallus	186-190
12529357-4	2003	The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor.	Aspartic Acid	39-42	epidermal growth factor	Gallus gallus	196-219
12540846-4	2003	Here we demonstrate that C5L2 binds the metabolites of C4a and C3a, C4a des-Arg(77), and C3a des-Arg(77) (also known as the acylation-stimulating protein or ASP) at a site distinct from the C5a binding site.	Aspartic Acid	157-160	complement C4A (Rodgers blood group)	Homo sapiens	55-58
12540846-4	2003	Here we demonstrate that C5L2 binds the metabolites of C4a and C3a, C4a des-Arg(77), and C3a des-Arg(77) (also known as the acylation-stimulating protein or ASP) at a site distinct from the C5a binding site.	Aspartic Acid	157-160	complement C3	Homo sapiens	89-92
12706306-6	2003	The other allele contained nine-base pair deletion, located in exon 8, eliminating codons 487-489 (Asp-Ser-Phe) near the carboxy-terminus of P450c17.	Aspartic Acid	99-102	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	141-148
12525479-3	2003	Substitution of several aspartate residues by asparagine completely abolished Ca(2+)-dependent membrane targeting of PKCalpha.	Aspartic Acid	24-33	protein kinase C, alpha	Rattus norvegicus	117-125
12641448-4	2003	Here we describe methods of both steady-state and half-reaction kinetic analysis of Ubc9, and use these techniques to determine the role of two residues, Asp(100) and Lys(101) of Ubc9 which are not found in E2 enzymes from other protein conjugation pathways.	Aspartic Acid	154-157	ubiquitin conjugating enzyme E2 I	Homo sapiens	179-183
12529320-3	2003	To test this hypothesis, we have constructed several mutants of TM456 and protein C in which charges of the putative interacting residues on both TM4 (Asp/Glu) and protein C (Lys/Arg) have been reversed.	Aspartic Acid	151-154	thrombomodulin	Homo sapiens	64-69
12641447-4	2003	By utilizing residue-specific chemical modification and site-directed mutagenesis techniques, we revealed that the acidic amino acid residues on PEDF (Asp(255), Asp(257), and Asp(299)) are critical to collagen binding, and three clustered basic amino acid residues (Arg(145), Lys(146), and Arg(148)) are necessary for heparin binding.	Aspartic Acid	151-154	serpin family F member 1	Homo sapiens	145-149
12641447-4	2003	By utilizing residue-specific chemical modification and site-directed mutagenesis techniques, we revealed that the acidic amino acid residues on PEDF (Asp(255), Asp(257), and Asp(299)) are critical to collagen binding, and three clustered basic amino acid residues (Arg(145), Lys(146), and Arg(148)) are necessary for heparin binding.	Aspartic Acid	161-164	serpin family F member 1	Homo sapiens	145-149
12641447-4	2003	By utilizing residue-specific chemical modification and site-directed mutagenesis techniques, we revealed that the acidic amino acid residues on PEDF (Asp(255), Asp(257), and Asp(299)) are critical to collagen binding, and three clustered basic amino acid residues (Arg(145), Lys(146), and Arg(148)) are necessary for heparin binding.	Aspartic Acid	161-164	serpin family F member 1	Homo sapiens	145-149
12646253-0	2003	Platelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561.	Aspartic Acid	104-107	von Willebrand factor	Homo sapiens	57-78
12628243-6	2003	The phosphorylation of the APC protein was mimicked by specific serine/aspartate mutations, which align to serine residues in the cytoplasmic beta-catenin binding domain of E-cadherin.	Aspartic Acid	71-80	APC regulator of WNT signaling pathway	Homo sapiens	27-30
12628243-6	2003	The phosphorylation of the APC protein was mimicked by specific serine/aspartate mutations, which align to serine residues in the cytoplasmic beta-catenin binding domain of E-cadherin.	Aspartic Acid	71-80	catenin beta 1	Homo sapiens	142-154
12628243-6	2003	The phosphorylation of the APC protein was mimicked by specific serine/aspartate mutations, which align to serine residues in the cytoplasmic beta-catenin binding domain of E-cadherin.	Aspartic Acid	71-80	cadherin 1	Homo sapiens	173-183
12482324-2	2003	Multiple sequence alignment of CYPs identified CYP2C9 Asp(293) as corresponding to Asp(301) of CYP2D6, which has been suggested to play a role in the binding of basic substrates to the latter enzyme.	Aspartic Acid	54-57	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	47-53
12446457-7	2003	Database comparisons with EAF2 identified a region with a high content of serine, aspartic acid, and glutamic acid residues that is conserved with EAF1 and exhibited amino acid similarity with several translocation partner proteins of MLL, including AF4 and ENL.	Aspartic Acid	82-95	ELL associated factor 2	Homo sapiens	26-30
12482324-2	2003	Multiple sequence alignment of CYPs identified CYP2C9 Asp(293) as corresponding to Asp(301) of CYP2D6, which has been suggested to play a role in the binding of basic substrates to the latter enzyme.	Aspartic Acid	54-57	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	95-101
12446457-7	2003	Database comparisons with EAF2 identified a region with a high content of serine, aspartic acid, and glutamic acid residues that is conserved with EAF1 and exhibited amino acid similarity with several translocation partner proteins of MLL, including AF4 and ENL.	Aspartic Acid	82-95	ELL associated factor 1	Homo sapiens	147-151
12446457-7	2003	Database comparisons with EAF2 identified a region with a high content of serine, aspartic acid, and glutamic acid residues that is conserved with EAF1 and exhibited amino acid similarity with several translocation partner proteins of MLL, including AF4 and ENL.	Aspartic Acid	82-95	lysine methyltransferase 2A	Homo sapiens	235-238
12482324-2	2003	Multiple sequence alignment of CYPs identified CYP2C9 Asp(293) as corresponding to Asp(301) of CYP2D6, which has been suggested to play a role in the binding of basic substrates to the latter enzyme.	Aspartic Acid	83-86	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	47-53
12482324-2	2003	Multiple sequence alignment of CYPs identified CYP2C9 Asp(293) as corresponding to Asp(301) of CYP2D6, which has been suggested to play a role in the binding of basic substrates to the latter enzyme.	Aspartic Acid	83-86	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	95-101
12482324-8	2003	Our analysis suggests a structural role for the carboxyl side chain of Asp(293) in CYP2C9 substrate binding and catalysis.	Aspartic Acid	71-74	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	83-89
12499385-7	2003	We show that ASP(+) (4-(4-(dimethylamino)styrl)-N-methylpyridinium) has micromolar potency for the human norepinephrine transporter, that ASP(+) accumulation is Na(+)-, Cl(-)-, cocaine-, and desipramine-sensitive and temperature-dependent, and that ASP(+) competes with norepinephrine uptake.	Aspartic Acid	13-19	solute carrier family 6 member 2	Homo sapiens	105-131
12499385-7	2003	We show that ASP(+) (4-(4-(dimethylamino)styrl)-N-methylpyridinium) has micromolar potency for the human norepinephrine transporter, that ASP(+) accumulation is Na(+)-, Cl(-)-, cocaine-, and desipramine-sensitive and temperature-dependent, and that ASP(+) competes with norepinephrine uptake.	Aspartic Acid	138-144	solute carrier family 6 member 2	Homo sapiens	105-131
12499385-7	2003	We show that ASP(+) (4-(4-(dimethylamino)styrl)-N-methylpyridinium) has micromolar potency for the human norepinephrine transporter, that ASP(+) accumulation is Na(+)-, Cl(-)-, cocaine-, and desipramine-sensitive and temperature-dependent, and that ASP(+) competes with norepinephrine uptake.	Aspartic Acid	138-144	solute carrier family 6 member 2	Homo sapiens	105-131
12506111-7	2003	We have found that cleavage of procaspase-9 at Asp(330) to generate p35, p10 or p37, p10 forms resulted in a significant increase (up to 8-fold) in apoptosome activity compared with p35/p12.	Aspartic Acid	47-50	interleukin 12A	Homo sapiens	68-71
12562917-8	2003	The actions of vitronectin were sensitive to RGD (Arg-Gly-Asp)-sequence-containing peptide, indicating the involvement of integrins as vitronectin receptors.	Aspartic Acid	58-61	vitronectin	Mus musculus	15-26
12562917-8	2003	The actions of vitronectin were sensitive to RGD (Arg-Gly-Asp)-sequence-containing peptide, indicating the involvement of integrins as vitronectin receptors.	Aspartic Acid	58-61	vitronectin	Mus musculus	135-146
12506122-3	2003	Mutation of Ser(212) to alanine enhanced the basal activity of MEK1, whereas the phosphomimetic aspartate mutation completely suppressed the activation of both wild-type MEK1 and the constitutively activated MEK1(S218D/S222D) mutant.	Aspartic Acid	96-105	serine/threonine protein kinase MEK1	Saccharomyces cerevisiae S288C	170-174
12506111-7	2003	We have found that cleavage of procaspase-9 at Asp(330) to generate p35, p10 or p37, p10 forms resulted in a significant increase (up to 8-fold) in apoptosome activity compared with p35/p12.	Aspartic Acid	47-50	S100 calcium binding protein A10	Homo sapiens	73-76
12506122-3	2003	Mutation of Ser(212) to alanine enhanced the basal activity of MEK1, whereas the phosphomimetic aspartate mutation completely suppressed the activation of both wild-type MEK1 and the constitutively activated MEK1(S218D/S222D) mutant.	Aspartic Acid	96-105	serine/threonine protein kinase MEK1	Saccharomyces cerevisiae S288C	170-174
12506111-7	2003	We have found that cleavage of procaspase-9 at Asp(330) to generate p35, p10 or p37, p10 forms resulted in a significant increase (up to 8-fold) in apoptosome activity compared with p35/p12.	Aspartic Acid	47-50	nucleoporin 37	Homo sapiens	80-83
12506111-7	2003	We have found that cleavage of procaspase-9 at Asp(330) to generate p35, p10 or p37, p10 forms resulted in a significant increase (up to 8-fold) in apoptosome activity compared with p35/p12.	Aspartic Acid	47-50	S100 calcium binding protein A10	Homo sapiens	85-88
12509351-7	2003	Moreover, substitution of Asp(938) and Asp(940) in the MHA2 H(+)-ATPase C terminus greatly decreased association with GF14-6, thereby demonstrating a crucial role of negatively charged residues in the fusicoccin-dependent interaction.	Aspartic Acid	26-29	14-3-3-like protein GF14-6	Zea mays	118-124
12506111-7	2003	We have found that cleavage of procaspase-9 at Asp(330) to generate p35, p10 or p37, p10 forms resulted in a significant increase (up to 8-fold) in apoptosome activity compared with p35/p12.	Aspartic Acid	47-50	interleukin 12A	Homo sapiens	182-185
12509351-7	2003	Moreover, substitution of Asp(938) and Asp(940) in the MHA2 H(+)-ATPase C terminus greatly decreased association with GF14-6, thereby demonstrating a crucial role of negatively charged residues in the fusicoccin-dependent interaction.	Aspartic Acid	39-42	14-3-3-like protein GF14-6	Zea mays	118-124
12595264-0	2003	Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue.	Aspartic Acid	83-92	protein phosphatase 1 regulatory inhibitor subunit 14A	Homo sapiens	59-65
12506111-7	2003	We have found that cleavage of procaspase-9 at Asp(330) to generate p35, p10 or p37, p10 forms resulted in a significant increase (up to 8-fold) in apoptosome activity compared with p35/p12.	Aspartic Acid	47-50	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	186-189
12595264-4	2003	There was a switch in the protein conformation due to either Asp substitution or phosphorylation, so we determined the solution NMR structure of the CPI-17 T38D mutant as a model for the active (phospho-) conformation.	Aspartic Acid	61-64	protein phosphatase 1 regulatory inhibitor subunit 14A	Homo sapiens	149-155
12506111-9	2003	In addition, cleavage at Asp(330) exposed a novel p10 NH(2)-terminal peptide motif (AISS) that retained the ability to mediate XIAP inhibition of caspase-9.	Aspartic Acid	25-28	S100 calcium binding protein A10	Homo sapiens	50-53
12506111-9	2003	In addition, cleavage at Asp(330) exposed a novel p10 NH(2)-terminal peptide motif (AISS) that retained the ability to mediate XIAP inhibition of caspase-9.	Aspartic Acid	25-28	X-linked inhibitor of apoptosis	Homo sapiens	127-131
12506111-9	2003	In addition, cleavage at Asp(330) exposed a novel p10 NH(2)-terminal peptide motif (AISS) that retained the ability to mediate XIAP inhibition of caspase-9.	Aspartic Acid	25-28	caspase 9	Homo sapiens	146-155
12477713-3	2003	Desmin is cleaved selectively at a conserved Asp residue in its L1-L2 linker domain (VEMD downward arrow M(264)) by caspase-6 in vitro and in myogenic cells undergoing apoptosis.	Aspartic Acid	45-48	desmin	Homo sapiens	0-6
12641536-1	2003	OBJECTIVE: Conflicting data exists about the possible contribution of the homozygous Asp/Asp genotype of the Glu298Asp polymorphism of endothelial nitric oxide synthase to human atherosclerotic vascular disease.	Aspartic Acid	85-88	nitric oxide synthase 3	Homo sapiens	135-168
12641536-1	2003	OBJECTIVE: Conflicting data exists about the possible contribution of the homozygous Asp/Asp genotype of the Glu298Asp polymorphism of endothelial nitric oxide synthase to human atherosclerotic vascular disease.	Aspartic Acid	89-92	nitric oxide synthase 3	Homo sapiens	135-168
12579557-4	2003	RGDS (Arg-Gly-Asp-Ser) peptide immobilization onto PE film resulted in almost the same differentiation activity as the collagen immobilized PE film.	Aspartic Acid	14-17	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	0-4
12562911-6	2003	Mutating the pore variant C-terminal to the GYG motif in HCN1, A352, to the analogous conserved Asp in K+ channels or Arg in HCN2 produced a significant hyperpolarizing activation shift (by 5-15 mV), slowed gating kinetics (up to 6-fold), and abolished or attenuated gating responses to external K+.	Aspartic Acid	96-99	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	57-61
12486123-10	2003	The sequence information produced by both methods identified specific labeled fragments of bovine Gbeta(1) that overlapped in the heptapeptide, Leu-Met-Thr-Tyr-Ser-His-Asp (amino acids 261-267).	Aspartic Acid	168-171	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	98-103
12496272-3	2003	The primary structure of the newly identified HDL-binding protein resembles GPI-anchored proteins consisting of an N-terminal signal sequence, an acidic region with a cluster of aspartate and glutamate residues, an Ly-6 motif highly conserved among the lymphocyte antigen family, and a C-terminal hydrophobic region.	Aspartic Acid	178-187	glucose-6-phosphate isomerase	Homo sapiens	76-79
12496244-0	2003	Modulation of estrogen receptor alpha function and stability by tamoxifen and a critical amino acid (Asp-538) in helix 12.	Aspartic Acid	101-104	estrogen receptor 1	Homo sapiens	14-37
12477713-3	2003	Desmin is cleaved selectively at a conserved Asp residue in its L1-L2 linker domain (VEMD downward arrow M(264)) by caspase-6 in vitro and in myogenic cells undergoing apoptosis.	Aspartic Acid	45-48	caspase 6	Homo sapiens	116-125
12477713-4	2003	We demonstrate that caspase cleavage of desmin at Asp(263) has important functional consequences, including the production of an amino-terminal cleavage product, N-desmin, which is unable to assemble into intermediate filaments, instead forming large intracellular aggregates.	Aspartic Acid	50-53	desmin	Homo sapiens	40-46
12477713-7	2003	Taken together, these results indicate that caspase proteolysis of desmin at Asp(263) produces a dominant-negative inhibitor of intermediate filaments and actively participates in the execution of apoptosis.	Aspartic Acid	77-80	desmin	Homo sapiens	67-73
12578369-3	2003	In this study, we have probed the role of this Asp in human 8-oxoguanine DNA glycosylase (hOgg1) by mutating it to Asn (D268N), Glu (D268E), and Gln (D268Q).	Aspartic Acid	47-50	8-oxoguanine DNA glycosylase	Homo sapiens	60-88
12644305-3	2003	Site-directed mutagenesis of Asp(229) was used to assess the effect of this site on the gonadotropin-releasing hormone receptor (GnRHR)-Galpha(s) mediated signaling in the absence or presence of over-expressed RGS3, RGS10 or a truncated form of RGS3 (RGS3T).	Aspartic Acid	29-32	gonadotropin releasing hormone receptor	Homo sapiens	88-127
12644305-3	2003	Site-directed mutagenesis of Asp(229) was used to assess the effect of this site on the gonadotropin-releasing hormone receptor (GnRHR)-Galpha(s) mediated signaling in the absence or presence of over-expressed RGS3, RGS10 or a truncated form of RGS3 (RGS3T).	Aspartic Acid	29-32	gonadotropin releasing hormone receptor	Homo sapiens	129-134
12578369-3	2003	In this study, we have probed the role of this Asp in human 8-oxoguanine DNA glycosylase (hOgg1) by mutating it to Asn (D268N), Glu (D268E), and Gln (D268Q).	Aspartic Acid	47-50	8-oxoguanine DNA glycosylase	Homo sapiens	90-95
12578369-4	2003	We show that this aspartate plays a dual role, acting both as an N-terminal alpha-helix cap and as a critical residue for catalysis of both base excision and DNA strand cleavage by hOgg1.	Aspartic Acid	18-27	8-oxoguanine DNA glycosylase	Homo sapiens	181-186
12574116-5	2003	A Mad2 mutant containing serine to aspartic acid mutations mimicking the C-terminal phosphorylation events fails to interact with Mad1 or the APC/C and acts as a dominant-negative antagonist of wild-type Mad2.	Aspartic Acid	35-48	mitotic arrest deficient 2 like 1	Homo sapiens	2-6
12591617-9	2003	Mutations in selected sites showed the importance of Asp-73, Cys-104, Arg-110 and Ser-111 in phosphatase activity of DUSP18.	Aspartic Acid	53-56	dual specificity phosphatase 18	Homo sapiens	117-123
12574116-5	2003	A Mad2 mutant containing serine to aspartic acid mutations mimicking the C-terminal phosphorylation events fails to interact with Mad1 or the APC/C and acts as a dominant-negative antagonist of wild-type Mad2.	Aspartic Acid	35-48	mitotic arrest deficient 2 like 1	Homo sapiens	204-208
12458195-11	2003	We propose that a conformational change related to the reprotonation of aspartates during or after the bond-breaking event is the rate-limiting segment in the catalytic reaction of beta-amyloid precursor protein-cleaving enzyme, and ligands binding to other than the ground-state forms of the enzyme might provide inhibitors of greater pharmacological relevance.	Aspartic Acid	72-82	beta-secretase 1	Homo sapiens	181-227
12578989-4	2003	Moreover, we identify one amino acid residue, Asp-55, specific to the LEC1-type B domain that is required for LEC1 activity in embryogenesis and sufficient to confer partial LEC1 activity to a non-LEC1-type B domain.	Aspartic Acid	46-49	Histone superfamily protein	Arabidopsis thaliana	70-74
12578989-4	2003	Moreover, we identify one amino acid residue, Asp-55, specific to the LEC1-type B domain that is required for LEC1 activity in embryogenesis and sufficient to confer partial LEC1 activity to a non-LEC1-type B domain.	Aspartic Acid	46-49	Histone superfamily protein	Arabidopsis thaliana	110-114
12578989-4	2003	Moreover, we identify one amino acid residue, Asp-55, specific to the LEC1-type B domain that is required for LEC1 activity in embryogenesis and sufficient to confer partial LEC1 activity to a non-LEC1-type B domain.	Aspartic Acid	46-49	Histone superfamily protein	Arabidopsis thaliana	110-114
12578989-4	2003	Moreover, we identify one amino acid residue, Asp-55, specific to the LEC1-type B domain that is required for LEC1 activity in embryogenesis and sufficient to confer partial LEC1 activity to a non-LEC1-type B domain.	Aspartic Acid	46-49	Histone superfamily protein	Arabidopsis thaliana	110-114
12578989-5	2003	Based on structural similarities between the HAP3 B domain and histone fold motif, we discuss how the Asp-55 residue may functionally differentiate LEC1 from the non-LEC1-type AHAP3 subunits.	Aspartic Acid	102-105	nuclear factor Y, subunit B1	Arabidopsis thaliana	45-49
12578989-5	2003	Based on structural similarities between the HAP3 B domain and histone fold motif, we discuss how the Asp-55 residue may functionally differentiate LEC1 from the non-LEC1-type AHAP3 subunits.	Aspartic Acid	102-105	Histone superfamily protein	Arabidopsis thaliana	148-152
12458209-4	2003	The validity of using the crystal structure of UvrB as a template for the development of an XPD model was tested by mimicking human disease-causing mutations (XPD: R112H, D234N, R601L) in UvrB (E110R, D338N, R506A) and by mutating two highly conserved residues (XPD, His-237 and Asp-609; UvrB, H341A and D510A).	Aspartic Acid	279-282	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	92-95
12388397-6	2003	Inhibition of CaM resulted in a significant change in the EC(50) value for the inhibition of ASP(+) uptake by tetraethylammonium.	Aspartic Acid	93-99	calmodulin 1	Homo sapiens	14-17
12446689-0	2003	Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.	Aspartic Acid	27-36	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	119-138
12446689-2	2003	CYP2D6 substrates typically contain a basic nitrogen atom, and the active-site residue Asp-301 has been implicated in substrate recognition through electrostatic interactions.	Aspartic Acid	87-90	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
12446689-12	2003	Neutralizing both Glu-216 and Asp-301 thus effectively alters substrate recognition illustrating the central role of the negative charges provided by both residues in defining the specificity of CYP2D6 toward substrates containing a basic nitrogen.	Aspartic Acid	30-33	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	195-201
12482857-5	2003	We specifically find that Imp1p prefers substrates having a negatively charged residue (Asp or Glu) at the +1 position, whereas Imp2p prefers substrates having the Met residue at the +1 position.	Aspartic Acid	88-91	endopeptidase catalytic subunit IMP1	Saccharomyces cerevisiae S288C	26-31
12388397-1	2003	Properties and regulation of the human organic cation (OC) transporter type 2 (hOCT2) expressed in HEK-293 cells were extensively characterized using the fluorescent OC 4-[4-(dimethylamino)styryl]-N-methylpyridinium (ASP(+)).	Aspartic Acid	217-220	POU class 2 homeobox 2	Homo sapiens	79-84
12393643-1	2003	Substitution of valine (Val) for aspartic acid (Asp) at codon 814 constitutively activates murine c-kit receptor tyrosine kinase (KIT), and Asp816Val mutation, corresponding to murine Asp814Val mutation, is found in patients with mastocytosis and acute myelocytic leukemia.	Aspartic Acid	33-46	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	100-103
12393643-1	2003	Substitution of valine (Val) for aspartic acid (Asp) at codon 814 constitutively activates murine c-kit receptor tyrosine kinase (KIT), and Asp816Val mutation, corresponding to murine Asp814Val mutation, is found in patients with mastocytosis and acute myelocytic leukemia.	Aspartic Acid	33-46	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	130-133
12393643-1	2003	Substitution of valine (Val) for aspartic acid (Asp) at codon 814 constitutively activates murine c-kit receptor tyrosine kinase (KIT), and Asp816Val mutation, corresponding to murine Asp814Val mutation, is found in patients with mastocytosis and acute myelocytic leukemia.	Aspartic Acid	48-51	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	100-103
12393643-1	2003	Substitution of valine (Val) for aspartic acid (Asp) at codon 814 constitutively activates murine c-kit receptor tyrosine kinase (KIT), and Asp816Val mutation, corresponding to murine Asp814Val mutation, is found in patients with mastocytosis and acute myelocytic leukemia.	Aspartic Acid	48-51	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	130-133
12535160-5	2003	In the presence of vasopressin/oxytocin, K+-stimulated glutamate and aspartate release were significantly reduced by 34% and 62%, respectively, in the SON.	Aspartic Acid	69-78	arginine vasopressin	Rattus norvegicus	19-30
12582120-1	2003	Ypd1p, a histidine-containing phosphotransfer protein, plays an important role in a branched His-Asp phosphorelay signal transduction pathway that regulates cellular responses to hyperosmotic stress in Saccharomyces cerevisiae.	Aspartic Acid	97-100	Ypd1p	Saccharomyces cerevisiae S288C	0-5
12579497-5	2003	RESULTS: Individuals carrying at least one 312Asn variant allele (Asp/Asn and Asn/Asn genotypes) were at an increased risk for lung SCC as compared with those with the Asp/Asp genotype (OR 1.80; 95% CI: 1.10-2.93; adjusted for age, sex and smoking), but this increased risk was not observed among patients with adenocarcinoma of the lung (adjusted OR: 1.07; 95% CI: 0.55-2.08).	Aspartic Acid	66-69	serpin family B member 3	Homo sapiens	132-135
12610214-0	2003	In vivo and in vitro characterization of the ARR11 response regulator implicated in the His-to-Asp phosphorelay signal transduction in Arabidopsis thaliana.	Aspartic Acid	95-98	response regulator 11	Arabidopsis thaliana	45-50
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Aspartic Acid	327-336	calsequestrin 1	Mus musculus	46-49
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Aspartic Acid	327-336	calsequestrin 1	Mus musculus	55-58
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Aspartic Acid	327-336	calsequestrin 1	Mus musculus	55-58
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Aspartic Acid	327-336	calsequestrin 1	Mus musculus	55-58
12419813-2	2003	Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects.	Aspartic Acid	327-336	calsequestrin 1	Mus musculus	55-58
12534281-9	2003	The catalytic triad of DP8 was shown to be Ser(739)-Asp (817)-His(849).	Aspartic Acid	52-55	dipeptidyl peptidase 8	Homo sapiens	23-26
12490315-1	2003	Wild type (wt) p21 Bax was cleaved to generate p18 Bax during apoptotic processes by calpain, which was suggested to recognize a certain motif around amino acids 30-33 Phe-Ile-Gln-Asp (FIQD).	Aspartic Acid	180-183	BCL2 associated X, apoptosis regulator	Homo sapiens	19-22
12490315-1	2003	Wild type (wt) p21 Bax was cleaved to generate p18 Bax during apoptotic processes by calpain, which was suggested to recognize a certain motif around amino acids 30-33 Phe-Ile-Gln-Asp (FIQD).	Aspartic Acid	180-183	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
12534283-4	2003	Mutational analysis of potential metal ion binding residues in the main ligand binding crevice of the CXCR4 receptor showed that although binding of the bicyclam is dependent on both Asp(171) and Asp(262), the enhancing effect of the metal ion was selectively eliminated by substitution of Asp(262) located at the extracellular end of TM-VI.	Aspartic Acid	183-186	C-X-C motif chemokine receptor 4	Homo sapiens	102-107
12534283-4	2003	Mutational analysis of potential metal ion binding residues in the main ligand binding crevice of the CXCR4 receptor showed that although binding of the bicyclam is dependent on both Asp(171) and Asp(262), the enhancing effect of the metal ion was selectively eliminated by substitution of Asp(262) located at the extracellular end of TM-VI.	Aspartic Acid	196-199	C-X-C motif chemokine receptor 4	Homo sapiens	102-107
12534283-4	2003	Mutational analysis of potential metal ion binding residues in the main ligand binding crevice of the CXCR4 receptor showed that although binding of the bicyclam is dependent on both Asp(171) and Asp(262), the enhancing effect of the metal ion was selectively eliminated by substitution of Asp(262) located at the extracellular end of TM-VI.	Aspartic Acid	196-199	C-X-C motif chemokine receptor 4	Homo sapiens	102-107
12517962-3	2003	The tapasin dependence of HLA class I alleles bearing different residues at position 114 decreases in the order of acidity, with high tapasin dependence for acidic amino acids (aspartic acid and glutamic acid), moderate dependence for neutral amino acids (asparagine and glutamine), and low dependence for basic amino acids (histidine and arginine).	Aspartic Acid	177-190	TAP binding protein	Homo sapiens	4-11
12424257-6	2003	Residue Asp-86 (in variable Region I of SULT1A3), on the other hand, is critical in the Mn(2+) stimulation of the Dopa/tyrosine-sulfating activity of SULT1A3.	Aspartic Acid	8-11	sulfotransferase family 1A member 3	Homo sapiens	40-47
12424257-6	2003	Residue Asp-86 (in variable Region I of SULT1A3), on the other hand, is critical in the Mn(2+) stimulation of the Dopa/tyrosine-sulfating activity of SULT1A3.	Aspartic Acid	8-11	sulfotransferase family 1A member 3	Homo sapiens	150-157
12559567-2	2003	We transformed this strain with a yeast nuclear library and we isolated among other suppressors, an unknown, non-essential gene (called SMM1, corresponding to open reading frame YNR015w), which restored the growth on glycerol and a normal amount of processed tRNA(Asp) in the mutant.	Aspartic Acid	264-267	tRNA-dihydrouridine(20) synthase (NAD(+))	Saccharomyces cerevisiae S288C	136-140
12513997-3	2003	By introducing the mutant-derived genomic library into a non-L-proline-utilizing strain, the mutant was found to carry an allele of the wild-type PRO1 gene encoding gamma-glutamyl kinase, which resulted in a single amino acid replacement; Asp (GAC) at position 154 was replaced by Asn (AAC).	Aspartic Acid	239-242	glutamate 5-kinase	Saccharomyces cerevisiae S288C	146-150
12350228-0	2003	A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells.	Aspartic Acid	33-46	cathepsin D	Mus musculus	68-79
12482550-5	2003	The methionine synthase gene (MTR) mutation is an A to G substitution, 2756A--&gt;G, which converts an aspartate to a glycine codon.	Aspartic Acid	103-112	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	4-23
12350228-1	2003	The substitution of an active-site aspartic acid residue by asparagine in the lysosomal protease cathepsin D (CTSD) results in a loss of enzyme activity and severe cerebrocortical atrophy in a novel form of neuronal ceroid lipofuscinosis in sheep [Tyynela, Sohar, Sleat, Gin, Donnelly, Baumann, Haltia and Lobel (2000) EMBO J.	Aspartic Acid	35-48	cathepsin D	Ovis aries	97-108
12350228-1	2003	The substitution of an active-site aspartic acid residue by asparagine in the lysosomal protease cathepsin D (CTSD) results in a loss of enzyme activity and severe cerebrocortical atrophy in a novel form of neuronal ceroid lipofuscinosis in sheep [Tyynela, Sohar, Sleat, Gin, Donnelly, Baumann, Haltia and Lobel (2000) EMBO J.	Aspartic Acid	35-48	cathepsin D	Ovis aries	110-114
12617942-10	2003	Together with the evidence for GABA(B) and adenosine A(1) receptor-mediated preferential inhibition of the N-methyl-D-aspartate component, the present results suggest that limiting glutamate spillover onto postsynaptic N-methyl-D-aspartate receptors may be a general rule for presynaptic modulation in midbrain dopamine neurons.	Aspartic Acid	118-127	adenosine A1 receptor	Rattus norvegicus	31-66
12459913-3	2003	In some PBGS, the cysteines of the metal switch sequence DXCXCX(Y/F)X(3)G(H/Q)CG have been demonstrated to bind a catalytic zinc, and in other PBGS, the aspartic acid residues of the metal switch sequence DXALDX(Y/F)X(3)G(H/Q)DG have been postulated to bind a catalytically essential magnesium and/or potassium.	Aspartic Acid	153-166	aminolevulinate dehydratase	Homo sapiens	8-12
12459913-3	2003	In some PBGS, the cysteines of the metal switch sequence DXCXCX(Y/F)X(3)G(H/Q)CG have been demonstrated to bind a catalytic zinc, and in other PBGS, the aspartic acid residues of the metal switch sequence DXALDX(Y/F)X(3)G(H/Q)DG have been postulated to bind a catalytically essential magnesium and/or potassium.	Aspartic Acid	153-166	aminolevulinate dehydratase	Homo sapiens	143-147
12459913-4	2003	The current work describes chimeric proteins that contain the aspartate-rich sequences of pea PBGS and Pseudomonas aeruginosa PBGS in place of the naturally occurring cysteine-rich sequence of human PBGS.	Aspartic Acid	62-71	aminolevulinate dehydratase	Homo sapiens	94-98
12459913-4	2003	The current work describes chimeric proteins that contain the aspartate-rich sequences of pea PBGS and Pseudomonas aeruginosa PBGS in place of the naturally occurring cysteine-rich sequence of human PBGS.	Aspartic Acid	62-71	aminolevulinate dehydratase	Homo sapiens	126-130
12459913-9	2003	Those PBGS with the aspartate-rich metal switch sequence contain Lys in the analogous position.	Aspartic Acid	20-29	aminolevulinate dehydratase	Homo sapiens	6-10
12643544-2	2003	The enzymes used were trypsin, Lys-C, and Asp-N, which cleave at arginine and lysine residues, lysine, and aspartic acid residues, respectively.	Aspartic Acid	107-120	asporin	Homo sapiens	42-47
12713798-2	2003	Therefore, a novel di-substituted analogue of GIP, (Ser(2)-Asp(13))GIP, containing a negatively charged Asp residue in place of an Ala in position 13, was synthesised and evaluated for in vitro biological activity.	Aspartic Acid	59-62	gastric inhibitory polypeptide	Rattus norvegicus	46-49
12713798-3	2003	Incubation with dipeptidyl peptidase IV (DPP IV) showed the half-lives of GIP and (Ser(2)-Asp(13))GIP to be 2.3 and &gt;4h, respectively.	Aspartic Acid	90-93	dipeptidylpeptidase 4	Rattus norvegicus	16-39
12713798-3	2003	Incubation with dipeptidyl peptidase IV (DPP IV) showed the half-lives of GIP and (Ser(2)-Asp(13))GIP to be 2.3 and &gt;4h, respectively.	Aspartic Acid	90-93	dipeptidylpeptidase 4	Rattus norvegicus	41-47
12713798-3	2003	Incubation with dipeptidyl peptidase IV (DPP IV) showed the half-lives of GIP and (Ser(2)-Asp(13))GIP to be 2.3 and &gt;4h, respectively.	Aspartic Acid	90-93	gastric inhibitory polypeptide	Rattus norvegicus	98-101
12713798-4	2003	Insulin releasing studies in clonal pancreatic BRIN-BD11 cells demonstrated that (Ser(2)-Asp(13))GIP (10(-12)to 10(-7)mol/l) was significantly less potent (60-90%; P&lt;0.05 to P&lt;0.001) than native GIP.	Aspartic Acid	89-92	gastric inhibitory polypeptide	Rattus norvegicus	97-100
12713798-6	2003	These results demonstrate that despite increased resistance to DPP IV, substituting Ala in position 13 with a negatively charged Asp, thus producing the di-substituted analogue (Ser(2)-Asp(13))GIP, significantly reduces biological activity, most likely due to modifications within the secondary structure.	Aspartic Acid	129-132	gastric inhibitory polypeptide	Rattus norvegicus	193-196
12713798-6	2003	These results demonstrate that despite increased resistance to DPP IV, substituting Ala in position 13 with a negatively charged Asp, thus producing the di-substituted analogue (Ser(2)-Asp(13))GIP, significantly reduces biological activity, most likely due to modifications within the secondary structure.	Aspartic Acid	185-188	gastric inhibitory polypeptide	Rattus norvegicus	193-196
14682610-2	2003	It is found that many CYP2D6-selective substrates are able to fit closely within the putative active site of the enzyme where there are favourable contacts with complementary amino acid residues, including aspartate-301 which has been probed via site-directed mutagenesis.	Aspartic Acid	206-215	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	22-28
12605854-4	2003	Our data suggest that the causal mutation, a G to A transition, is localised in exon 2 of the MATP gene leading to an aspartic acid to asparagine substitution in the encoded protein.	Aspartic Acid	118-131	solute carrier family 45 member 2	Equus caballus	94-98
15373684-4	2003	While the 378 C&gt;T and 624 T&gt;C are silent mutations, the 793A&gt;G polymorphism in codon 265 encodes asparagine for Doa and aspartic acid for Dob.	Aspartic Acid	129-142	major histocompatibility complex, class II, DO beta	Homo sapiens	147-150
12482991-4	2003	Serine 927 resides in a conserved motif (Asp-Ser(927)-Gly-Val-Glu-Thr-Ser(932)) homologous to the IKK target sequence in IkappaBalpha.	Aspartic Acid	41-44	NFKB inhibitor alpha	Homo sapiens	121-133
12559130-0	2003	Lysine 195 and aspartate 196 in the first extracellular loop of the VPAC1 receptor are essential for high affinity binding of agonists but not of antagonists.	Aspartic Acid	15-24	vasoactive intestinal peptide receptor 1	Homo sapiens	68-82
12559130-1	2003	The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the human VPAC(1) receptor was investigated in stably transfected CHO cells expressing the wild type or point mutated receptors.Replacement of lysine 195 by glutamine or of aspartate 196 by asparagine reduced the agonists" ability to stimulate adenylate cyclase activity; VIP behaved like a partial agonist and a partial agonist behaved as an antagonist.	Aspartic Acid	104-113	vasoactive intestinal peptide receptor 1	Homo sapiens	164-180
12732238-4	2003	The soluble RGD-containing peptide glycine-arginine-glycine-aspartate-serine-proline (GRGDSP) increased neurotrophin mRNA levels in transcript- and subfield-specific fashions.	Aspartic Acid	60-69	brain derived neurotrophic factor	Homo sapiens	104-116
12509534-10	2003	A mutant form of NtADF1 with a nonphosphorylatable Ala substitution at its Ser-6 position [NtADF1(S6A)] shows increased activity, whereas the mutant NtADF1(S6D), which has a phospho-mimicking Asp substitution at the same position, shows reduced ability to counteract the effect of NtRac1.	Aspartic Acid	192-195	actin-depolymerizing factor 7-like	Nicotiana tabacum	17-23
12509534-10	2003	A mutant form of NtADF1 with a nonphosphorylatable Ala substitution at its Ser-6 position [NtADF1(S6A)] shows increased activity, whereas the mutant NtADF1(S6D), which has a phospho-mimicking Asp substitution at the same position, shows reduced ability to counteract the effect of NtRac1.	Aspartic Acid	192-195	actin-depolymerizing factor 7-like	Nicotiana tabacum	91-97
12509534-10	2003	A mutant form of NtADF1 with a nonphosphorylatable Ala substitution at its Ser-6 position [NtADF1(S6A)] shows increased activity, whereas the mutant NtADF1(S6D), which has a phospho-mimicking Asp substitution at the same position, shows reduced ability to counteract the effect of NtRac1.	Aspartic Acid	192-195	actin-depolymerizing factor 7-like	Nicotiana tabacum	91-97
12471154-4	2002	Mutation of the conserved Asp-759 in human eIF5B GTP-binding domain to Asn converts eIF5B to an XTPase and introduces an XTP requirement for subunit joining and translation initiation.	Aspartic Acid	26-29	eukaryotic translation initiation factor 5B	Homo sapiens	43-48
12493827-8	2003	A single additional mutation of arginine to aspartic acid allowed for recovery of native structure and increased the thermal stability of the designed Src-p85 chimera by 18 degrees C. This modification appears to relieve an unfavorable surface electrostatic interaction, demonstrating the importance of surface charge interactions in protein stability.	Aspartic Acid	44-57	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
12493827-8	2003	A single additional mutation of arginine to aspartic acid allowed for recovery of native structure and increased the thermal stability of the designed Src-p85 chimera by 18 degrees C. This modification appears to relieve an unfavorable surface electrostatic interaction, demonstrating the importance of surface charge interactions in protein stability.	Aspartic Acid	44-57	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	155-158
14989558-0	2003	Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298--&gt;Asp) variant in determining endothelial function in coronary artery disease.	Aspartic Acid	94-97	nitric oxide synthase 3	Homo sapiens	56-63
14989558-3	2003	The purpose of this study was to determine the influence of the homozygous G849T (Glu298--&gt;Asp) polymorphism in NOS III on peripheral conduit artery endothelial function and to elucidate the modifier role, if any, of a common ACE polymorphism.	Aspartic Acid	94-97	angiotensin I converting enzyme	Homo sapiens	229-232
12458022-6	2002	However, PNGase F was observed to incorporate two (18)O into the beta-carboxyl groups of the Asp residue.	Aspartic Acid	93-96	N-glycanase 1	Homo sapiens	9-15
12471154-4	2002	Mutation of the conserved Asp-759 in human eIF5B GTP-binding domain to Asn converts eIF5B to an XTPase and introduces an XTP requirement for subunit joining and translation initiation.	Aspartic Acid	26-29	eukaryotic translation initiation factor 5B	Homo sapiens	84-89
12324475-6	2002	We demonstrated that P49 is able to inhibit insect and human effector caspases, which requires P49 cleavage at Asp(94).	Aspartic Acid	111-114	DNA primase subunit 1	Homo sapiens	21-24
12324475-6	2002	We demonstrated that P49 is able to inhibit insect and human effector caspases, which requires P49 cleavage at Asp(94).	Aspartic Acid	111-114	DNA primase subunit 1	Homo sapiens	95-98
12454455-0	2002	The impact of Glu--&gt;Ala and Glu--&gt;Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution.	Aspartic Acid	40-43	Rho GDP dissociation inhibitor alpha	Homo sapiens	91-97
12226088-2	2002	We predict that the conserved portion of Sds22 folds into a curved superhelix and demonstrate that mutation to alanine of any of eight residues (Asp(148), Phe(170), Glu(192), Phe(214), Asp(280), Glu(300), Trp(302), or Tyr(327)) at the concave surface of this superhelix thwarts the interaction with PP1.	Aspartic Acid	145-148	protein phosphatase 1 regulatory subunit 7	Homo sapiens	41-46
12226088-2	2002	We predict that the conserved portion of Sds22 folds into a curved superhelix and demonstrate that mutation to alanine of any of eight residues (Asp(148), Phe(170), Glu(192), Phe(214), Asp(280), Glu(300), Trp(302), or Tyr(327)) at the concave surface of this superhelix thwarts the interaction with PP1.	Aspartic Acid	185-188	protein phosphatase 1 regulatory subunit 7	Homo sapiens	41-46
12466963-6	2002	Surprisingly, GASP, a fusion product of green fluorescence protein (GFP) and ASP(67), a peptide composed of the 67 C-terminal amino acid residues of AChE-S, localized to COS1 cell nuclei.	Aspartic Acid	15-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	149-153
12419389-1	2002	Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements.	Aspartic Acid	87-100	tankyrase	Homo sapiens	0-6
12454455-4	2002	In the current paper, an analysis of the impact of surface mutations replacing Glu residues with Ala or Asp on the stability and crystallization properties of RhoGDI is presented.	Aspartic Acid	104-107	Rho GDP dissociation inhibitor alpha	Homo sapiens	159-165
12464013-2	2002	Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding.	Aspartic Acid	44-47	CD47 molecule	Homo sapiens	116-203
12464013-2	2002	Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding.	Aspartic Acid	44-47	CD47 molecule	Homo sapiens	205-208
12464013-2	2002	Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding.	Aspartic Acid	44-47	CD47 molecule	Homo sapiens	210-214
12417729-4	2002	We biochemically mapped an apoptotic cleavage site at residue Asp-279 (D(279)) of hRad21.	Aspartic Acid	62-65	RAD21 cohesin complex component	Homo sapiens	82-88
22905400-0	2002	Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B.	Aspartic Acid	81-84	apolipoprotein B	Homo sapiens	105-121
22905400-1	2002	The collective normal modes of the hexapeptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B (apo B), have been obtained.	Aspartic Acid	64-67	apolipoprotein B	Homo sapiens	88-104
22905400-1	2002	The collective normal modes of the hexapeptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B (apo B), have been obtained.	Aspartic Acid	64-67	apolipoprotein B	Homo sapiens	106-111
12475387-3	2002	Three molecular forms of insulin were isolated from the tetraploid organism X. laevis that represent insulin-1 and insulin-2, as deduced from the nucleotide sequences of previously characterized cDNAs, and a third form which differed from insulin-2 by the single amino acid substitution Asp(21)--&gt;Glu in the B-chain.	Aspartic Acid	287-290	insulin S homeolog	Xenopus laevis	25-32
12537667-1	2002	The alpha v beta 3 integrin, a transmembrane heterodimeric protein expressed on sprouting endothelial cells, binds to the arginine-glycine-aspartic acid (RGD) amino acid sequence of extracellular matrix proteins such as vitronectin.	Aspartic Acid	139-152	vitronectin	Mus musculus	220-231
12507437-3	2002	Our results show that introduction of Asp in position 4 similarly affects the binding to the MC1, MC4 and MC5 receptors, but drastically lowers the binding to the MC3 receptor.	Aspartic Acid	38-41	melanocortin 3 receptor	Homo sapiens	163-166
12482029-5	2002	Conversion of E1046 to either arginine (E 1046R), alanine (E1046A), aspartic acid (E1046D) or glutamine (E1046Q) abolished Jak2 kinase activity as measured by autophosphorylation assays.	Aspartic Acid	68-81	Janus kinase 2	Homo sapiens	123-127
12507437-5	2002	Introduction of Asp in position 10, mimicking gamma-MSH, decreased the affinity for the MC3 receptor in similar manner as for the MC4 receptor, suggesting that there are important differences in the binding conformation of gamma-MSH and NPD-MSH.	Aspartic Acid	16-19	proopiomelanocortin	Homo sapiens	46-55
12507437-5	2002	Introduction of Asp in position 10, mimicking gamma-MSH, decreased the affinity for the MC3 receptor in similar manner as for the MC4 receptor, suggesting that there are important differences in the binding conformation of gamma-MSH and NPD-MSH.	Aspartic Acid	16-19	melanocortin 3 receptor	Homo sapiens	88-91
12507437-5	2002	Introduction of Asp in position 10, mimicking gamma-MSH, decreased the affinity for the MC3 receptor in similar manner as for the MC4 receptor, suggesting that there are important differences in the binding conformation of gamma-MSH and NPD-MSH.	Aspartic Acid	16-19	proopiomelanocortin	Homo sapiens	223-232
12507437-5	2002	Introduction of Asp in position 10, mimicking gamma-MSH, decreased the affinity for the MC3 receptor in similar manner as for the MC4 receptor, suggesting that there are important differences in the binding conformation of gamma-MSH and NPD-MSH.	Aspartic Acid	16-19	proopiomelanocortin	Homo sapiens	52-55
12497758-3	2002	Allgrove syndrome is caused by mutations in the AAAS gene located at chromosome 12q13, which encodes for a tryptophan-aspartic acid (WD) repeat protein (aladin).	Aspartic Acid	118-131	aladin WD repeat nucleoporin	Homo sapiens	48-52
12467579-4	2002	The crystal structure of E. coli PEPC (EcPEPC) complexed with Mn(2+), phosphoenolpyruvate analog (3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate), and an allosteric inhibitor, aspartate, has also been determined at 2.35 A resolution.	Aspartic Acid	184-193	phosphoenolpyruvate carboxylase 1	Zea mays	33-37
12481071-5	2002	One mutation is expected to completely abolish the enzymatic activity of RSW1(CESA1) because it eliminated one of three conserved Asp residues, which are considered essential for beta-glycosyltransferase activity.	Aspartic Acid	130-133	cellulose synthase 1	Arabidopsis thaliana	73-77
12481071-5	2002	One mutation is expected to completely abolish the enzymatic activity of RSW1(CESA1) because it eliminated one of three conserved Asp residues, which are considered essential for beta-glycosyltransferase activity.	Aspartic Acid	130-133	cellulose synthase 1	Arabidopsis thaliana	78-83
12593721-4	2002	Recently, a D727E (Asp to Glu) SNP in the intracellular C-terminal domain of the TSHR was reported to be associated with GD in a Russian population.	Aspartic Acid	19-22	thyroid stimulating hormone receptor	Homo sapiens	81-85
12497758-3	2002	Allgrove syndrome is caused by mutations in the AAAS gene located at chromosome 12q13, which encodes for a tryptophan-aspartic acid (WD) repeat protein (aladin).	Aspartic Acid	118-131	aladin WD repeat nucleoporin	Homo sapiens	153-159
12239216-5	2002	In addition, mutating the two phenylalanine residues in the PIP-box to alanine or aspartic acid reduces binding to PCNA, confirming that the PIP-box in RRM3 is responsible for interaction with PCNA.	Aspartic Acid	82-95	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	115-119
12297503-3	2002	Of the eight acidic residues, mutation of any of three in exo-loop 2, Asp(758), Glu(759), and Glu(767), increased the sensitivity of both the full-length hCaR and of Rho-C-hCaR to activation by Ca(2+).	Aspartic Acid	70-73	CXADR Ig-like cell adhesion molecule	Homo sapiens	154-158
12297503-3	2002	Of the eight acidic residues, mutation of any of three in exo-loop 2, Asp(758), Glu(759), and Glu(767), increased the sensitivity of both the full-length hCaR and of Rho-C-hCaR to activation by Ca(2+).	Aspartic Acid	70-73	CXADR Ig-like cell adhesion molecule	Homo sapiens	172-176
12244056-9	2002	Therefore, AAP6 and -8 are the only members of the family able to transport aspartate with physiologically relevant affinity.	Aspartic Acid	76-85	amino acid permease 6	Arabidopsis thaliana	11-22
12228253-2	2002	The high affinity of SHBG for 2-MeOE2 relies primarily on hydrogen bonding between the hydroxyl at C-3 of 2-MeOE2 and Asp(65) and an interaction between the methoxy group at C-2 and the amido group of Asn(82).	Aspartic Acid	118-121	sex hormone binding globulin	Homo sapiens	21-25
12228253-2	2002	The high affinity of SHBG for 2-MeOE2 relies primarily on hydrogen bonding between the hydroxyl at C-3 of 2-MeOE2 and Asp(65) and an interaction between the methoxy group at C-2 and the amido group of Asn(82).	Aspartic Acid	118-121	complement C3	Homo sapiens	99-102
12228253-6	2002	The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82).	Aspartic Acid	156-159	sex hormone binding globulin	Homo sapiens	23-27
12228253-6	2002	The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82).	Aspartic Acid	156-159	complement C2	Homo sapiens	77-80
12244094-3	2002	Maximal binding of the Raf kinase domain to MEK1 and its kinase activity are achieved upon phosphorylation of the region (338)SSYY(341) in response to 4beta-12-O-tetradecanoylphorbol-13-acetate (TPA), or mutation of Y340Y341 to aspartic acids.	Aspartic Acid	228-242	zinc fingers and homeoboxes 2	Homo sapiens	23-26
12239216-5	2002	In addition, mutating the two phenylalanine residues in the PIP-box to alanine or aspartic acid reduces binding to PCNA, confirming that the PIP-box in RRM3 is responsible for interaction with PCNA.	Aspartic Acid	82-95	DNA helicase	Saccharomyces cerevisiae S288C	152-156
12244094-3	2002	Maximal binding of the Raf kinase domain to MEK1 and its kinase activity are achieved upon phosphorylation of the region (338)SSYY(341) in response to 4beta-12-O-tetradecanoylphorbol-13-acetate (TPA), or mutation of Y340Y341 to aspartic acids.	Aspartic Acid	228-242	mitogen-activated protein kinase kinase 1	Homo sapiens	44-48
12228221-6	2002	Our previous studies using point-mutated M-form PSTs established that the Mn(2+) (in the substrate-Mn(2+) complex) exerts its stimulatory effect by binding predominantly to the Asp-86 residue at the active site.	Aspartic Acid	177-180	kallikrein related peptidase 4	Homo sapiens	48-52
12429500-7	2002	With an aspartic acid at position 58 in 17beta-HSD-3 occupying the equivalent space in the cofactor binding pocket as arginine 224 in glutathione reductase or serine 12 in 17beta-HSD-1, there was an expectation that some of the mutants might use NADH as a cofactor.	Aspartic Acid	8-21	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	40-52
12429500-7	2002	With an aspartic acid at position 58 in 17beta-HSD-3 occupying the equivalent space in the cofactor binding pocket as arginine 224 in glutathione reductase or serine 12 in 17beta-HSD-1, there was an expectation that some of the mutants might use NADH as a cofactor.	Aspartic Acid	8-21	glutathione-disulfide reductase	Homo sapiens	134-155
12376561-6	2002	The actions of IGFBP-3 and -5 on cell attachment to ECM were lost in the presence of a soluble Arg-Gly-Asp (RGD)-containing fibronectin fragment.	Aspartic Acid	103-106	insulin like growth factor binding protein 3	Homo sapiens	15-29
12423336-4	2002	Compared to wild-type, Met53Glu/Asp AMY1 displayed 117/90% activity towards insoluble Blue Starch, and Met53Ala/Ser/Gly 76/58/38%, but Met53Tyr/Trp only 0.9/0.1%, even though both Asp and Trp occur frequently at this position in family 13.	Aspartic Acid	32-35	LOC548210	Hordeum vulgare	36-40
12376561-6	2002	The actions of IGFBP-3 and -5 on cell attachment to ECM were lost in the presence of a soluble Arg-Gly-Asp (RGD)-containing fibronectin fragment.	Aspartic Acid	103-106	fibronectin 1	Homo sapiens	124-135
12137567-9	2002	As phosphorylation of ED serine residues prevented gp63-mediated MRP degradation, we synthesized a pseudophosphorylated peptide in which serine residues were substituted by aspartate (3DMRP(ED)).	Aspartic Acid	173-182	leishmanolysin like peptidase	Homo sapiens	51-55
12386133-10	2002	A common genetic variation results in aspartate (UGT2B15*1) or tyrosine (UGT2B15*2) at position 85 of the UGT2B15 protein.	Aspartic Acid	38-47	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	49-56
12588044-3	2002	One goal of this study was to expand the studies on LHR and determine whether the invariant Glu and Asp residues were functional in FSHR and TSHR as well.	Aspartic Acid	100-103	follicle stimulating hormone receptor	Rattus norvegicus	132-136
12588044-3	2002	One goal of this study was to expand the studies on LHR and determine whether the invariant Glu and Asp residues were functional in FSHR and TSHR as well.	Aspartic Acid	100-103	thyroid stimulating hormone receptor	Rattus norvegicus	141-145
12376566-5	2002	These data demonstrate that thrombospondin-1-induced cell chemotaxis can be inhibited by a peptide containing the Arg-Gly-Asp motif, a function-blocking alpha(v)beta(3) antibody, a function-blocking integrin-associated protein (IAP) antibody and pertussis toxin, while thrombospondin-1-stimulated DNA synthesis is inhibited by a function-blocking alpha(3)beta(1) antibody.	Aspartic Acid	122-125	thrombospondin 1	Homo sapiens	28-44
12424587-2	2002	Citrin, an aspartate glutamate carrier in mitochondria, is an essential component of the malate-aspartate NADH shuttle.	Aspartic Acid	11-20	solute carrier family 25 member 13	Homo sapiens	0-6
12424587-2	2002	Citrin, an aspartate glutamate carrier in mitochondria, is an essential component of the malate-aspartate NADH shuttle.	Aspartic Acid	96-105	solute carrier family 25 member 13	Homo sapiens	0-6
12423336-4	2002	Compared to wild-type, Met53Glu/Asp AMY1 displayed 117/90% activity towards insoluble Blue Starch, and Met53Ala/Ser/Gly 76/58/38%, but Met53Tyr/Trp only 0.9/0.1%, even though both Asp and Trp occur frequently at this position in family 13.	Aspartic Acid	180-183	LOC548210	Hordeum vulgare	36-40
12507235-8	2002	RESULTS: Adherent cells on Ti plates, with and without GDP, were significantly reduced in serum-free conditions and the presence of RGDS (Arg-Gly-Asp-Ser) peptides.	Aspartic Acid	146-149	ral guanine nucleotide dissociation stimulator	Mus musculus	132-136
12200419-6	2002	Substitution of the conserved Glu(500) in CPTII with alanine or aspartate reduced the V(max) for both substrates, suggesting that Glu(500) may be important in stabilization of the enzyme-substrate complex.	Aspartic Acid	64-73	carnitine palmitoyltransferase 2	Rattus norvegicus	42-47
12186871-3	2002	We replaced three charged amino acids, Lys(332), His(335), and Asp(336), predicted to be in the sixth transmembrane (TM6) helix of MRP1 with neutral and oppositely charged amino acids and determined the effect on substrate specificity and transport activity.	Aspartic Acid	63-66	ATP binding cassette subfamily C member 1	Homo sapiens	131-135
12186871-9	2002	In contrast to the selective loss of LTC(4) transport in the Lys(332) and His(335) mutants, the MRP1-Asp(336) mutants no longer transported LTC(4), E(2)17betaG, estrone 3-sulfate, or GSH, and transport of MTX was reduced by &gt;50%.	Aspartic Acid	101-104	ATP binding cassette subfamily C member 1	Homo sapiens	96-100
12186871-11	2002	The importance of Lys(332) and His(335) in determining substrate specificity and of Asp(336) in overall transport activity suggests that such interactions are critical for the binding and transport of LTC(4) and other substrates of MRP1.	Aspartic Acid	84-87	ATP binding cassette subfamily C member 1	Homo sapiens	232-236
12499702-2	2002	A Gly and Asp substitution at position 169 of the mouse Nramp protein is invariably associated with the resistant and susceptible phenotypes, respectively.	Aspartic Acid	10-13	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	56-61
12438443-8	2002	Mahoganoid effects on energy homeostasis are, therefore, most evident in the circumstances of epistasis to hypothalamic overexpression of ASP in A(y) and possible other obesity-causing mutations.	Aspartic Acid	138-141	mahogunin, ring finger 1	Mus musculus	0-10
12391606-6	2002	These results suggest that mutations or modifications at positions Glu 22 and Asp 23 have a pathogenic role in the deposition of A beta.	Aspartic Acid	78-81	amyloid beta precursor protein	Homo sapiens	129-135
12391608-2	2002	Racemization of Ser and Asp in A beta is a typical age-dependent modification in AD.	Aspartic Acid	24-27	amyloid beta precursor protein	Homo sapiens	31-37
12411514-0	2002	Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding.	Aspartic Acid	75-78	solute carrier family 4 member 4	Homo sapiens	51-56
12411514-0	2002	Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding.	Aspartic Acid	85-88	solute carrier family 4 member 4	Homo sapiens	51-56
12411514-4	2002	In the current study, we examined the role of the negative charge on Ser(982)-phosphate and three aspartate residues in a D986NDD custer in altering the stoichiometry of kNBC1.	Aspartic Acid	98-107	solute carrier family 4 member 4	Homo sapiens	170-175
12411514-7	2002	The data indicate that both kNBC1-Asp(986) and kNBC1-Asp(988), but not kNBC1-Asp(989), are required for the phosphorylation-induced shift in stoichiometry.	Aspartic Acid	34-37	solute carrier family 4 member 4	Homo sapiens	28-33
12411514-7	2002	The data indicate that both kNBC1-Asp(986) and kNBC1-Asp(988), but not kNBC1-Asp(989), are required for the phosphorylation-induced shift in stoichiometry.	Aspartic Acid	53-56	solute carrier family 4 member 4	Homo sapiens	47-52
12411514-7	2002	The data indicate that both kNBC1-Asp(986) and kNBC1-Asp(988), but not kNBC1-Asp(989), are required for the phosphorylation-induced shift in stoichiometry.	Aspartic Acid	53-56	solute carrier family 4 member 4	Homo sapiens	47-52
12411514-7	2002	The data indicate that both kNBC1-Asp(986) and kNBC1-Asp(988), but not kNBC1-Asp(989), are required for the phosphorylation-induced shift in stoichiometry.	Aspartic Acid	53-56	solute carrier family 4 member 4	Homo sapiens	47-52
12411514-7	2002	The data indicate that both kNBC1-Asp(986) and kNBC1-Asp(988), but not kNBC1-Asp(989), are required for the phosphorylation-induced shift in stoichiometry.	Aspartic Acid	53-56	solute carrier family 4 member 4	Homo sapiens	47-52
12363464-0	2002	Detection of c-kit point mutation Asp-816 --&gt; Val in microdissected pooled single mast cells and leukemic cells in a patient with systemic mastocytosis and concomitant chronic myelomonocytic leukemia.	Aspartic Acid	34-37	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	13-18
12363464-1	2002	The c-kit mutation Asp-816--&gt;Val is detectable not only in neoplastic mast cells (MCs) in patients with systemic mastocytosis (SM) but also in most associated hematologic non-MC lineage disease (AHNMD).	Aspartic Acid	19-22	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	4-9
12145316-8	2002	The other two residues (Phe-234 and Ser-274) and another three TPR domain residues not definitively associated with the binding groove (Leu-284, Lys-285, and Asp-329) are required for efficient Hsp90 binding.	Aspartic Acid	158-161	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	194-199
12475640-12	2002	In vitro mutagenesis experiments indicate that Cys(144) and aspartates in positions 187-191 of LH3 are important for the galactosyltransferase activity.	Aspartic Acid	60-70	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	95-98
12866717-5	2002	We suggest that cortical glutamatergic neurons possess 5-HT1B heteroceptors and their activation may be responsible for the inhibitory effect of 5-HT on Glu and Asp release.	Aspartic Acid	161-164	5-hydroxytryptamine receptor 1B	Rattus norvegicus	55-61
12924029-1	2002	At weak acidic pH, where HIV-1 proteinase is most stable and active, its catalytic Asp 25/25" dyad shares one proton.	Aspartic Acid	83-86	endogenous retrovirus group K member 25	Homo sapiens	31-41
12181318-3	2002	Here we report the mutation of Ser(214) in thrombin to Ala, Thr, Cys, Asp, Glu, and Lys.	Aspartic Acid	70-73	coagulation factor II, thrombin	Homo sapiens	43-51
12186867-4	2002	Unlike conventional stop transfer sequences, however, TM8 is unable to independently terminate translocation due to the presence of a single charged residue, Asp(924), within the TM segment.	Aspartic Acid	158-161	tetraspanin 16	Homo sapiens	54-57
12194967-5	2002	2) Within the effector domains, Di-Ras has Ile at a position corresponding to Asp-33 in Ha-Ras, which is important for its interaction with the downstream effector Raf.	Aspartic Acid	78-81	zinc fingers and homeoboxes 2	Homo sapiens	164-167
12189142-10	2002	In addition, chimeric analysis of Rab3A and Rab27A showed that the specific sequence of the switch II region of Rab27 isoforms (especially Leu-84, Phe-88, and Asp-91 of Rab27A), which is not conserved in the Rab3 or Rab8 isoforms, is essential for recognition by the Slac2-a SHD.	Aspartic Acid	159-162	RAB3A, member RAS oncogene family	Homo sapiens	34-39
12189142-10	2002	In addition, chimeric analysis of Rab3A and Rab27A showed that the specific sequence of the switch II region of Rab27 isoforms (especially Leu-84, Phe-88, and Asp-91 of Rab27A), which is not conserved in the Rab3 or Rab8 isoforms, is essential for recognition by the Slac2-a SHD.	Aspartic Acid	159-162	RAB27A, member RAS oncogene family	Homo sapiens	44-50
12189142-10	2002	In addition, chimeric analysis of Rab3A and Rab27A showed that the specific sequence of the switch II region of Rab27 isoforms (especially Leu-84, Phe-88, and Asp-91 of Rab27A), which is not conserved in the Rab3 or Rab8 isoforms, is essential for recognition by the Slac2-a SHD.	Aspartic Acid	159-162	RAB27A, member RAS oncogene family	Homo sapiens	44-49
12189142-10	2002	In addition, chimeric analysis of Rab3A and Rab27A showed that the specific sequence of the switch II region of Rab27 isoforms (especially Leu-84, Phe-88, and Asp-91 of Rab27A), which is not conserved in the Rab3 or Rab8 isoforms, is essential for recognition by the Slac2-a SHD.	Aspartic Acid	159-162	RAB27A, member RAS oncogene family	Homo sapiens	169-175
12189142-10	2002	In addition, chimeric analysis of Rab3A and Rab27A showed that the specific sequence of the switch II region of Rab27 isoforms (especially Leu-84, Phe-88, and Asp-91 of Rab27A), which is not conserved in the Rab3 or Rab8 isoforms, is essential for recognition by the Slac2-a SHD.	Aspartic Acid	159-162	RAB8A, member RAS oncogene family	Homo sapiens	216-220
12163505-5	2002	Nsp4 adopts the smallest known chymotrypsin-like fold with a canonical catalytic triad of Ser-120, His-39, and Asp-65, as well as a novel alpha/beta C-terminal extension domain that may play a role in mediating protein-protein interactions.	Aspartic Acid	111-114	serine protease 57	Homo sapiens	0-4
12189142-10	2002	In addition, chimeric analysis of Rab3A and Rab27A showed that the specific sequence of the switch II region of Rab27 isoforms (especially Leu-84, Phe-88, and Asp-91 of Rab27A), which is not conserved in the Rab3 or Rab8 isoforms, is essential for recognition by the Slac2-a SHD.	Aspartic Acid	159-162	melanophilin	Homo sapiens	267-274
12369818-3	2002	To verify the conclusion further and obtain more detailed structural information about this PUF, five hydrophobic core residues in the N-terminal helix were mutated to Gly and Asp to destabilize the native state selectively and populate the PUF for structural studies.	Aspartic Acid	176-179	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	92-95
12459266-5	2002	The presence of this motif, together with a conserved order and spacing of the Ser, Asp, and His residues that form the catalytic triad in DPP IV, places DPP9 in the "DPP IV gene family".	Aspartic Acid	84-87	dipeptidyl peptidase 9	Homo sapiens	154-158
12459266-5	2002	The presence of this motif, together with a conserved order and spacing of the Ser, Asp, and His residues that form the catalytic triad in DPP IV, places DPP9 in the "DPP IV gene family".	Aspartic Acid	84-87	dipeptidyl peptidase 4	Homo sapiens	167-173
12369824-9	2002	In addition, mutating aspartic acid 121 (to asparagine), which forms part of a caspase cleavage site (DLRD, residues 118-121 of Cdc42), in combination with the F28L mutation generates a Cdc42 molecule [Cdc42(F28L/D121N)] with transforming activity significantly stronger than that of Cdc42(F28L).	Aspartic Acid	22-35	cell division cycle 42	Homo sapiens	128-133
12369824-9	2002	In addition, mutating aspartic acid 121 (to asparagine), which forms part of a caspase cleavage site (DLRD, residues 118-121 of Cdc42), in combination with the F28L mutation generates a Cdc42 molecule [Cdc42(F28L/D121N)] with transforming activity significantly stronger than that of Cdc42(F28L).	Aspartic Acid	22-35	cell division cycle 42	Homo sapiens	186-191
12369824-9	2002	In addition, mutating aspartic acid 121 (to asparagine), which forms part of a caspase cleavage site (DLRD, residues 118-121 of Cdc42), in combination with the F28L mutation generates a Cdc42 molecule [Cdc42(F28L/D121N)] with transforming activity significantly stronger than that of Cdc42(F28L).	Aspartic Acid	22-35	cell division cycle 42	Homo sapiens	186-191
12369824-9	2002	In addition, mutating aspartic acid 121 (to asparagine), which forms part of a caspase cleavage site (DLRD, residues 118-121 of Cdc42), in combination with the F28L mutation generates a Cdc42 molecule [Cdc42(F28L/D121N)] with transforming activity significantly stronger than that of Cdc42(F28L).	Aspartic Acid	22-35	cell division cycle 42	Homo sapiens	186-191
12239147-1	2002	FLT3 mutations, either internal tandem duplications (ITDs) or aspartate residue 835 (D835) point mutations, are present in approximately one third of patients with acute myeloid leukemia (AML) and have been associated with an increased relapse rate.	Aspartic Acid	62-71	fms related receptor tyrosine kinase 3	Homo sapiens	0-4
12460116-11	2002	The following residues should be noted: lysine forming a Schiff base with the PLP aldehyde group, an adjacent histidine, and aspartic acid that establishes a link with nitrogen of the PLP pyridine ring.	Aspartic Acid	125-138	proteolipid protein 1	Homo sapiens	184-187
12149252-6	2002	Additional studies revealed that the internal salt bridge (Ile(16)-Asp(194)) of factor Xa(Y225P) is partially destabilized, a process that is reversible upon occupation of the S1 site.	Aspartic Acid	67-70	coagulation factor X	Homo sapiens	80-89
19649236-3	2002	Direct sequencing of calsequestrin 2 (CASQ2), a candidate gene from within the linkage interval, revealed a negatively charged aspartic acid change to a positively charged histidine at position 307 of the protein.	Aspartic Acid	127-140	calsequestrin 2	Homo sapiens	21-36
19649236-3	2002	Direct sequencing of calsequestrin 2 (CASQ2), a candidate gene from within the linkage interval, revealed a negatively charged aspartic acid change to a positively charged histidine at position 307 of the protein.	Aspartic Acid	127-140	calsequestrin 2	Homo sapiens	38-43
12368168-0	2002	Identification and functional characterization of a new hemoglobin variant in Sardinia: Hb Muravera [beta47 GAT->GTT, (CD6) Asp->Val].	Aspartic Acid	124-127	CD6 molecule	Homo sapiens	119-122
12394387-6	2002	Sequencing of maltase-glucoamylase cDNA revealed homozygosity for a nucleotide change (C1673T) in the infant, which causes an amino acid substitution (S542L) 12 amino acids after the N-terminal catalytic aspartic acid.	Aspartic Acid	204-217	maltase-glucoamylase	Homo sapiens	14-34
12364359-11	2002	The functional difference in NO generation depending on eNOS with either glutamate or aspartate at position 298 was also confirmed in vitro.	Aspartic Acid	86-95	nitric oxide synthase 3	Homo sapiens	56-60
12395288-5	2002	Incubation of rOCT1-expressing HEK293 cells for 10 min with 100 mM 8-Br-cGMP reduced initial ASP + uptake by maximally 78% with an IC50 value of 24 +/- 16 mM.	Aspartic Acid	93-98	solute carrier family 22 member 1	Rattus norvegicus	14-19
12395288-7	2002	An inhibition of ASP + uptake by rOCT1 in HEK293 cells was also obtained when the cells were incubated for 10 min with 100 mM cGMP, whereas no effect was obtained when cGMP was given together with ASP +.	Aspartic Acid	17-22	solute carrier family 22 member 1	Rattus norvegicus	33-38
12395288-7	2002	An inhibition of ASP + uptake by rOCT1 in HEK293 cells was also obtained when the cells were incubated for 10 min with 100 mM cGMP, whereas no effect was obtained when cGMP was given together with ASP +.	Aspartic Acid	197-202	solute carrier family 22 member 1	Rattus norvegicus	33-38
12379490-14	2002	These studies postulate that an arginine-glycine-aspartic acid sequence found on mouse GHBP but absent in other species is responsible for the association of GHBP with the plasma membrane by binding to one or more integrins on the surface of liver cells.	Aspartic Acid	49-62	growth hormone receptor	Mus musculus	87-91
12379490-14	2002	These studies postulate that an arginine-glycine-aspartic acid sequence found on mouse GHBP but absent in other species is responsible for the association of GHBP with the plasma membrane by binding to one or more integrins on the surface of liver cells.	Aspartic Acid	49-62	growth hormone receptor	Mus musculus	158-162
12244298-4	2002	The increased potency arises primarily from the formation of two additional hydrogen bonds between the inhibitor and Asp 86 of CDK2, which facilitate optimum hydrophobic packing of the anilino group with the specificity surface of CDK2.	Aspartic Acid	117-120	cyclin dependent kinase 2	Homo sapiens	127-131
12242308-5	2002	We tested predictions deduced from these models by mutagenesis studies and found evidence for novel direct interactions between the E47 helix-loop-helix domain (Arg 357 or Asp 358) and the Pip N terminus (Leu 24).	Aspartic Acid	172-175	transcription factor 3	Homo sapiens	132-135
12242308-5	2002	We tested predictions deduced from these models by mutagenesis studies and found evidence for novel direct interactions between the E47 helix-loop-helix domain (Arg 357 or Asp 358) and the Pip N terminus (Leu 24).	Aspartic Acid	172-175	prolactin induced protein	Homo sapiens	189-192
12244298-4	2002	The increased potency arises primarily from the formation of two additional hydrogen bonds between the inhibitor and Asp 86 of CDK2, which facilitate optimum hydrophobic packing of the anilino group with the specificity surface of CDK2.	Aspartic Acid	117-120	cyclin dependent kinase 2	Homo sapiens	231-235
12366806-8	2002	We also showed using a transient expression assay system, that the dls1 mutation results in a decreased degradation of proteins with Asp or Glu at their N-termini, and that the introduction of the wild-type AtATE1 gene reverses this deficiency.	Aspartic Acid	133-136	arginine-tRNA protein transferase 1	Arabidopsis thaliana	67-71
12500171-1	2002	OBJECTIVES: The content of C-Fos protein was tested in rat pinealocytes in the norm and stress and in case of intranasal administration of Epitalon (Ala-Glu-Asp-Gly), which regulated pineal secretion processes, presumably, via protooncogenes.	Aspartic Acid	157-160	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
12366806-8	2002	We also showed using a transient expression assay system, that the dls1 mutation results in a decreased degradation of proteins with Asp or Glu at their N-termini, and that the introduction of the wild-type AtATE1 gene reverses this deficiency.	Aspartic Acid	133-136	arginine-tRNA protein transferase 1	Arabidopsis thaliana	207-213
12121981-1	2002	At the primary structure level, the 90-kDa heat shock protein (HSP90) is composed of three regions: the N-terminal (Met(1)-Arg(400)), middle (Glu(401)-Lys(615)), and C-terminal (Asp(621)-Asp(732)) regions.	Aspartic Acid	178-181	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	63-68
12145294-2	2002	Asp(1080) lies within an acidic sequence between the C-terminal inhibitory region and the catalytic core of PMCAs and is part of the caspase-3 recognition site of isoform 4b.	Aspartic Acid	0-3	caspase 3	Homo sapiens	133-142
12145294-7	2002	Asp(1080) had not been believed to have any other role, but here we show that it also plays a critical role in the autoinhibition and calmodulin activation of PMCA4b.	Aspartic Acid	0-3	calmodulin 1	Homo sapiens	134-144
12145294-7	2002	Asp(1080) had not been believed to have any other role, but here we show that it also plays a critical role in the autoinhibition and calmodulin activation of PMCA4b.	Aspartic Acid	0-3	ATPase plasma membrane Ca2+ transporting 4	Homo sapiens	159-165
12124386-0	2002	The role of Asp-462 in regulating Akt activity.	Aspartic Acid	12-15	AKT serine/threonine kinase 1	Homo sapiens	34-37
12124386-10	2002	Furthermore, we demonstrated residue Asp-462 of Akt1 which is just upstream of the hydrophobic motif to be the primary cleavage site.	Aspartic Acid	37-40	AKT serine/threonine kinase 1	Homo sapiens	48-52
12121981-1	2002	At the primary structure level, the 90-kDa heat shock protein (HSP90) is composed of three regions: the N-terminal (Met(1)-Arg(400)), middle (Glu(401)-Lys(615)), and C-terminal (Asp(621)-Asp(732)) regions.	Aspartic Acid	187-190	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	63-68
12221279-7	2002	Mutation of serine 104, the site of phosphorylation by protein kinase A in ARPP-19, to either alanine or aspartate abolished this regulation in PC12 cells.	Aspartic Acid	105-114	cAMP-regulated phosphoprotein 19	Rattus norvegicus	75-82
12220174-2	2002	Previous studies on KR-ET-1 showed that, in contrast to ET-1, this engineered compound displays a pH-dependent conformational change related to the formation of a stabilizing salt bridge between the Arg(-)(1) and Asp(8) side chains.	Aspartic Acid	213-216	endothelin 1	Homo sapiens	23-27
12093812-3	2002	We identify two aspartate residues, Asp(672) and Asp(682), as important determinants of the Ca(2+) sensitivity of the TRPV4 pore.	Aspartic Acid	16-25	transient receptor potential cation channel subfamily V member 4	Homo sapiens	118-123
12093812-3	2002	We identify two aspartate residues, Asp(672) and Asp(682), as important determinants of the Ca(2+) sensitivity of the TRPV4 pore.	Aspartic Acid	36-39	transient receptor potential cation channel subfamily V member 4	Homo sapiens	118-123
12093812-3	2002	We identify two aspartate residues, Asp(672) and Asp(682), as important determinants of the Ca(2+) sensitivity of the TRPV4 pore.	Aspartic Acid	49-52	transient receptor potential cation channel subfamily V member 4	Homo sapiens	118-123
12118014-8	2002	The converse double mutant, but neither single mutation alone, introduced into an exon B background (arginine to aspartic acid and cysteine to lysine) was able to restore the NCX1.4 regulatory phenotype.	Aspartic Acid	113-126	solute carrier family 8 member A1	Rattus norvegicus	175-179
12115475-5	2002	To encourage cell adhesion, PEUUs were surface modified with radio-frequency glow discharge followed by coupling of Arg-Gly-Asp-Ser (RGDS).	Aspartic Acid	124-127	ral guanine nucleotide dissociation stimulator	Homo sapiens	133-137
12118014-9	2002	These data demonstrate that aspartic acid 610 and lysine 617 (using the rat NCX1.4 numbering scheme) are critical molecular determinants of the unique Ca(2+) regulatory properties of NCX1.4.	Aspartic Acid	28-41	solute carrier family 8 member A1	Rattus norvegicus	76-80
12118014-9	2002	These data demonstrate that aspartic acid 610 and lysine 617 (using the rat NCX1.4 numbering scheme) are critical molecular determinants of the unique Ca(2+) regulatory properties of NCX1.4.	Aspartic Acid	28-41	solute carrier family 8 member A1	Rattus norvegicus	183-187
12400683-1	2002	The maize response regulator genes ZmRR1 and ZmRR2 respond to cytokinin, and the translated products seem to be involved in nitrogen signal transduction mediated by cytokinin through the His-Asp phosphorelay.	Aspartic Acid	191-194	cytokinin response regulator 2	Zea mays	45-50
12243508-7	2002	Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s.	Aspartic Acid	17-20	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	73-76
12243508-7	2002	Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s.	Aspartic Acid	146-149	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	73-76
12243508-7	2002	Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s.	Aspartic Acid	146-149	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	73-76
12223216-9	2002	This study clearly shows that mutation of aspartic acid residues in the C-terminal end of hsp30 or its truncation disrupts secondary structure and impairs its chaperone activity.	Aspartic Acid	42-55	heat shock protein 30E L homeolog	Xenopus laevis	90-95
12208735-7	2002	As assessed by site-directed mutagenesis, the activity of GrB was directed toward aspartic acid residues that were different from those of recombinant caspase-3.	Aspartic Acid	82-95	granzyme B	Homo sapiens	58-61
12213887-6	2002	The IRS-2 Gly(1057)Asp allele frequencies were 0.85 (Gly) and 0.15 (Asp) in African-Americans and 0.59 (Gly) and 0.41 (Asp) in whites.	Aspartic Acid	19-22	insulin receptor substrate 2	Homo sapiens	4-9
12189164-5	2002	All three affected siblings were homozygous for a 3 bp inframe deletion in exon 3 of the TNFRSF11B gene, resulting in the loss of an aspartate residue.	Aspartic Acid	133-142	TNF receptor superfamily member 11b	Homo sapiens	89-98
12204120-1	2002	Cathepsin E, an intracellular aspartic proteinase of the pepsin family, is composed of two homologous domains, each containing the catalytic Asp residue in a consensus DTG motif.	Aspartic Acid	141-144	cathepsin E	Homo sapiens	0-11
12213887-6	2002	The IRS-2 Gly(1057)Asp allele frequencies were 0.85 (Gly) and 0.15 (Asp) in African-Americans and 0.59 (Gly) and 0.41 (Asp) in whites.	Aspartic Acid	68-71	insulin receptor substrate 2	Homo sapiens	4-9
12068020-6	2002	Finally, the Ala substitution of two negatively charged residues in exosite II, Asp(100) and Asp(178), is found unexpectedly to significantly increase thrombomodulin binding.	Aspartic Acid	80-83	thrombomodulin	Homo sapiens	151-165
12322785-3	2002	The purpose of this report is to determine if the administration of a specific caspase-9 inhibitor, Z-Leu-Glu(Ome)-His-Asp(Ome)-FMK x TFA (Z-LEHD-FMK) would attenuate apoptosis and the resultant brain injury after ischemia.	Aspartic Acid	119-122	caspase 9	Rattus norvegicus	79-88
12200459-6	2002	In common with orthologues from other species, human tMDC III contains a putative integrin-binding glu-cys-asp (ECD) motif, the relevance of which is discussed in the context of a possible role in oolemma binding.	Aspartic Acid	107-110	ADAM metallopeptidase domain 18	Homo sapiens	53-61
12068020-6	2002	Finally, the Ala substitution of two negatively charged residues in exosite II, Asp(100) and Asp(178), is found unexpectedly to significantly increase thrombomodulin binding.	Aspartic Acid	93-96	thrombomodulin	Homo sapiens	151-165
12070159-5	2002	The results suggest that constitutive LHR activation by mutations at Asp-556(6.44) is triggered by the breakage or weakening of the interaction found in the wild type receptor between Asp-556(6.44) and Asn-593(7.45).	Aspartic Acid	69-72	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	38-41
12200134-3	2002	Purification of caspase-14 from native skin with subsequent N-terminal sequencing of the small subunit and tryptic digest analysis of the large subunit revealed an atypical processing site between Ile152 and Lys153, which distinguishes it from other caspases described to date that are processed at aspartate residues.	Aspartic Acid	299-308	caspase 14	Homo sapiens	16-26
12070159-5	2002	The results suggest that constitutive LHR activation by mutations at Asp-556(6.44) is triggered by the breakage or weakening of the interaction found in the wild type receptor between Asp-556(6.44) and Asn-593(7.45).	Aspartic Acid	184-187	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	38-41
12070159-6	2002	Whereas this perturbation is unique to the activating mutations at Asp-556(6.44), common features to all of the most active LHR mutants are the breakage of the charge-reinforced H-bonding interaction between Arg-442(3.50) and Asp-542(6.30) and the increase in solvent accessibility of the cytosolic extensions of helices 3 and 6, which probably participate in the receptor-G protein interface.	Aspartic Acid	226-229	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	124-127
12068021-6	2002	In the H15D histidine-containing protein (HPr), phosphorylation of the active site aspartate catalyzes the formation of a cyclic intermediate.	Aspartic Acid	83-92	haptoglobin-related protein	Homo sapiens	42-45
12186555-5	2002	Mutation of beta-arrestin2 phosphorylation sites to aspartic acid decreases the association of beta-arrestin2 with clathrin, thereby reducing its ability to promote internalization of the beta(2)-adrenergic receptor.	Aspartic Acid	52-65	arrestin beta 2	Homo sapiens	12-26
12186555-5	2002	Mutation of beta-arrestin2 phosphorylation sites to aspartic acid decreases the association of beta-arrestin2 with clathrin, thereby reducing its ability to promote internalization of the beta(2)-adrenergic receptor.	Aspartic Acid	52-65	arrestin beta 2	Homo sapiens	95-109
12070148-10	2002	Surprisingly the malate-aspartate shuttle inhibitor enabled pyruvate-stimulated insulin secretion.	Aspartic Acid	24-33	insulin	Homo sapiens	80-87
12042323-0	2002	Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.	Aspartic Acid	127-130	glutamyl aminopeptidase	Homo sapiens	139-155
12167405-1	2002	The Drosophila excitatory amino acid transporters dEAAT1 and dEAAT2 are nervous-specific transmembrane proteins that mediate the high affinity uptake of L-glutamate or aspartate into cells.	Aspartic Acid	168-177	Excitatory amino acid transporter 1	Drosophila melanogaster	50-56
12167405-1	2002	The Drosophila excitatory amino acid transporters dEAAT1 and dEAAT2 are nervous-specific transmembrane proteins that mediate the high affinity uptake of L-glutamate or aspartate into cells.	Aspartic Acid	168-177	Excitatory amino acid transporter 2	Drosophila melanogaster	61-67
12034723-4	2002	In this study, site-directed mutagenesis and chimeric analysis between Syt I and Syt VII showed that three Asp residues in Ca2+-binding loop 1 or 3 (Asp-172, Asp-303, and Asp-357) are crucial to robust Ca(2+)-dependent oligomerization.	Aspartic Acid	107-110	synaptotagmin 1	Rattus norvegicus	71-76
12034723-4	2002	In this study, site-directed mutagenesis and chimeric analysis between Syt I and Syt VII showed that three Asp residues in Ca2+-binding loop 1 or 3 (Asp-172, Asp-303, and Asp-357) are crucial to robust Ca(2+)-dependent oligomerization.	Aspartic Acid	107-110	synaptotagmin 7	Rattus norvegicus	81-88
12034723-4	2002	In this study, site-directed mutagenesis and chimeric analysis between Syt I and Syt VII showed that three Asp residues in Ca2+-binding loop 1 or 3 (Asp-172, Asp-303, and Asp-357) are crucial to robust Ca(2+)-dependent oligomerization.	Aspartic Acid	149-152	synaptotagmin 1	Rattus norvegicus	71-76
12034723-4	2002	In this study, site-directed mutagenesis and chimeric analysis between Syt I and Syt VII showed that three Asp residues in Ca2+-binding loop 1 or 3 (Asp-172, Asp-303, and Asp-357) are crucial to robust Ca(2+)-dependent oligomerization.	Aspartic Acid	149-152	synaptotagmin 7	Rattus norvegicus	81-88
12034723-4	2002	In this study, site-directed mutagenesis and chimeric analysis between Syt I and Syt VII showed that three Asp residues in Ca2+-binding loop 1 or 3 (Asp-172, Asp-303, and Asp-357) are crucial to robust Ca(2+)-dependent oligomerization.	Aspartic Acid	149-152	synaptotagmin 1	Rattus norvegicus	71-76
12034723-4	2002	In this study, site-directed mutagenesis and chimeric analysis between Syt I and Syt VII showed that three Asp residues in Ca2+-binding loop 1 or 3 (Asp-172, Asp-303, and Asp-357) are crucial to robust Ca(2+)-dependent oligomerization.	Aspartic Acid	149-152	synaptotagmin 7	Rattus norvegicus	81-88
12034723-4	2002	In this study, site-directed mutagenesis and chimeric analysis between Syt I and Syt VII showed that three Asp residues in Ca2+-binding loop 1 or 3 (Asp-172, Asp-303, and Asp-357) are crucial to robust Ca(2+)-dependent oligomerization.	Aspartic Acid	149-152	synaptotagmin 1	Rattus norvegicus	71-76
12151600-10	2002	We show here that the replacement of the residues responsible for these hindrances (Asp-309 and Tyr-227, respectively) by Ala allows ACPT-II or MAP4 to fully activate the receptors.	Aspartic Acid	84-87	microtubule associated protein 4	Homo sapiens	144-148
12034723-4	2002	In this study, site-directed mutagenesis and chimeric analysis between Syt I and Syt VII showed that three Asp residues in Ca2+-binding loop 1 or 3 (Asp-172, Asp-303, and Asp-357) are crucial to robust Ca(2+)-dependent oligomerization.	Aspartic Acid	149-152	synaptotagmin 7	Rattus norvegicus	81-88
12128178-2	2002	In the mutant lysozyme, a surface aspartate residue has been replaced with a hydrophobic phenylalanine residue.	Aspartic Acid	34-43	lysozyme	Homo sapiens	14-22
12029080-7	2002	Interestingly, PKS11 can also be activated by substitution of either a serine or tyrosine with aspartate within the activation loop.	Aspartic Acid	95-104	CBL-interacting protein kinase 8	Arabidopsis thaliana	15-20
12209506-10	2002	Linkage analysis results were consistent with the association; most of the TNFR2 linkage evidence was found in the subgroup of families with 196R/R ASP index cases.	Aspartic Acid	148-151	TNF receptor superfamily member 1B	Homo sapiens	75-80
12147673-8	2002	Inactivating PS1 or PS2 function by mutagenesis of one of the critical aspartate residues or by gamma-secretase inhibitors results in delayed reinternalization of the beta-amyloid precursor protein and its accumulation at the cell surface.	Aspartic Acid	71-80	presenilin 1	Homo sapiens	13-16
12147673-8	2002	Inactivating PS1 or PS2 function by mutagenesis of one of the critical aspartate residues or by gamma-secretase inhibitors results in delayed reinternalization of the beta-amyloid precursor protein and its accumulation at the cell surface.	Aspartic Acid	71-80	presenilin 2	Homo sapiens	20-23
12102725-3	2002	We report here on a method for the one-pot regioselective synthesis of an analogue of the EGF-1 domain of human coagulation Factor VII (residues 45-83) comprising an Asn57beta-Asp substitution.	Aspartic Acid	176-179	G elongation factor mitochondrial 1	Homo sapiens	90-95
12124262-6	2002	The subsequent simulation on Arg-207-Ala (R207A) mutation of gelsolin indicated that this mutation facilitates the unbinding of the tail helix and that the contribution of the hydrogen bond between Arg-207 and Asp-744 to the binding is more than 50%, which offers a new clue for further mutagenesis study on the activation mechanism of gelsolin.	Aspartic Acid	210-213	gelsolin	Homo sapiens	61-69
12124262-6	2002	The subsequent simulation on Arg-207-Ala (R207A) mutation of gelsolin indicated that this mutation facilitates the unbinding of the tail helix and that the contribution of the hydrogen bond between Arg-207 and Asp-744 to the binding is more than 50%, which offers a new clue for further mutagenesis study on the activation mechanism of gelsolin.	Aspartic Acid	210-213	gelsolin	Homo sapiens	336-344
12062854-2	2002	For example, there is evidence suggesting that vitamin D binding protein (DBP) amino acid variants at codons 416 (aspartic acid--&gt;glutamic acid) and 420 (threonine--&gt;lysine) may affect genetic susceptibility to T2DM.	Aspartic Acid	114-127	GC vitamin D binding protein	Homo sapiens	47-72
12062854-2	2002	For example, there is evidence suggesting that vitamin D binding protein (DBP) amino acid variants at codons 416 (aspartic acid--&gt;glutamic acid) and 420 (threonine--&gt;lysine) may affect genetic susceptibility to T2DM.	Aspartic Acid	114-127	D-box binding PAR bZIP transcription factor	Homo sapiens	74-77
12118066-5	2002	Both mutation of a key aspartate residue of myotubularin and dominant activation of Rac1 GTPase lead to the recruitment of myotubularin to specific plasma membrane domains.	Aspartic Acid	23-32	myotubularin 1	Homo sapiens	44-56
12118066-5	2002	Both mutation of a key aspartate residue of myotubularin and dominant activation of Rac1 GTPase lead to the recruitment of myotubularin to specific plasma membrane domains.	Aspartic Acid	23-32	myotubularin 1	Homo sapiens	123-135
12102725-3	2002	We report here on a method for the one-pot regioselective synthesis of an analogue of the EGF-1 domain of human coagulation Factor VII (residues 45-83) comprising an Asn57beta-Asp substitution.	Aspartic Acid	176-179	coagulation factor VII	Homo sapiens	112-134
12240950-0	2002	Characterization of asparagine deamidation and aspartate isomerization in recombinant human interleukin-11.	Aspartic Acid	47-56	interleukin 11	Homo sapiens	92-106
12097605-1	2002	Aspartate 368 on human immunodeficiency virus type 1 (HIV-1) gp120 forms multiple contacts with CD4; in mutagenesis studies, its replacement by asparagine and corresponding changes in simian immunodeficiency virus SIVmac (D385N) reduced binding with CD4.	Aspartic Acid	0-9	CD4 molecule	Homo sapiens	96-99
12097605-1	2002	Aspartate 368 on human immunodeficiency virus type 1 (HIV-1) gp120 forms multiple contacts with CD4; in mutagenesis studies, its replacement by asparagine and corresponding changes in simian immunodeficiency virus SIVmac (D385N) reduced binding with CD4.	Aspartic Acid	0-9	CD4 molecule	Homo sapiens	250-253
12145341-3	2002	One of the hFSHR mutations examined in this context was the substitution of a highly conserved aspartate (D581) in TM6 with glycine.	Aspartic Acid	95-104	follicle stimulating hormone receptor	Homo sapiens	11-16
12127976-0	2002	Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.	Aspartic Acid	11-14	secretoglobin family 1A member 1	Homo sapiens	38-49
12142634-2	2002	L-Asparagine is an essential amino acid for many lymphoid tumor cells and L-asparaginase catalyzes its conversion to L-aspartic acid and ammonia.	Aspartic Acid	117-132	asparaginase and isoaspartyl peptidase 1	Homo sapiens	74-88
12127976-0	2002	Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.	Aspartic Acid	11-14	phospholipase A2 group IB	Homo sapiens	72-88
12176333-6	2002	Expression of a Pak1 mutant in which Thr 212 is replaced with a phosphomimic (aspartic acid) has marked effects on the rate and extent of postmitotic spreading of fibroblasts.	Aspartic Acid	78-91	p21 (RAC1) activated kinase 1	Homo sapiens	16-20
12011074-5	2002	In bid-deficient mice, caspase-3 activation was arrested after the initial cleavage at Asp(175).	Aspartic Acid	87-90	BH3 interacting domain death agonist	Mus musculus	3-6
12011074-5	2002	In bid-deficient mice, caspase-3 activation was arrested after the initial cleavage at Asp(175).	Aspartic Acid	87-90	caspase 3	Mus musculus	23-32
11994275-2	2002	Calpain binds to the N-terminal region of DNA ligase III, which contains an acidic proline, aspartate, serine, and threonine (PEST) domain frequently present in proteins cleaved by calpain.	Aspartic Acid	92-101	DNA ligase 3	Homo sapiens	42-56
12121764-2	2002	KatGs, CCP and APXs contain identical amino acid triads in the heme pocket (distal Arg/Trp/His and proximal His/Trp/Asp), but differ dramatically in their reactivities towards hydrogen peroxide and various one-electron donors.	Aspartic Acid	116-119	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	7-10
12123836-3	2002	The effect of neurotensin was found to result from an increase in cell surface expression of EAAC1 and accordingly, cytochalasin D and colchicine were shown to block the effect of neurotensin on aspartate uptake, suggesting that the cytoskeleton participates in this regulation.	Aspartic Acid	195-204	neurotensin	Homo sapiens	14-25
12123805-2	2002	To determine whether the RGD (Arg-Gly-Asp) motif of IGFBP-2 mediates cell surface binding in vivo, we mutated the RGD motif of IGFBP-2 into an RGE (Arg-Gly-Glu) sequence and produced transgenic mice (E mice) which express elevated amounts of mutated IGFBP-2.	Aspartic Acid	38-41	insulin-like growth factor binding protein 2	Mus musculus	52-59
12110845-5	2002	We mutated an essential aspartate of the Ca(2+)-binding site of the synaptotagmin I C(2)A domain and expressed it in Drosophila lacking synaptotagmin I.	Aspartic Acid	24-33	Synaptotagmin 1	Drosophila melanogaster	68-83
12123836-3	2002	The effect of neurotensin was found to result from an increase in cell surface expression of EAAC1 and accordingly, cytochalasin D and colchicine were shown to block the effect of neurotensin on aspartate uptake, suggesting that the cytoskeleton participates in this regulation.	Aspartic Acid	195-204	solute carrier family 1 member 1	Homo sapiens	93-98
12123836-3	2002	The effect of neurotensin was found to result from an increase in cell surface expression of EAAC1 and accordingly, cytochalasin D and colchicine were shown to block the effect of neurotensin on aspartate uptake, suggesting that the cytoskeleton participates in this regulation.	Aspartic Acid	195-204	neurotensin	Homo sapiens	180-191
11994276-7	2002	However, digestion of (32)PO(4)-labeled DAT with endoproteinase asp-N and immunoprecipitation with an N-terminal antiserum extracted two phosphopeptide fragments from both basal and PKC/OA-stimulated samples, demonstrating that the N-terminal cytoplasmic tail is a major site of phosphorylation.	Aspartic Acid	64-67	solute carrier family 6 member 3	Rattus norvegicus	40-43
12150955-3	2002	We show that the epitope for the non-blocking mAb is the residue Asp(105) of chick ephrin-A2.	Aspartic Acid	65-68	ephrin A2	Gallus gallus	83-92
11994281-2	2002	Mutation of Tyr(356) of Galpha(11) to Phe, within a receptor contact domain, had little effect on function but this was reduced greatly by alteration to Ser and virtually eliminated by conversion to Asp.	Aspartic Acid	199-202	guanine nucleotide binding protein, alpha 11	Mus musculus	24-34
11994281-5	2002	Information transfer by agonist was controlled in residue 356 Galpha(11) mutants with rank order Tyr &gt; Phe &gt; Trp &gt; Ile &gt; Ala = Gln = Arg &gt; Ser &gt; Asp, although these alterations did not alter the binding affinity of either phenylephrine or an antagonist ligand.	Aspartic Acid	163-166	guanine nucleotide binding protein, alpha 11	Mus musculus	62-72
12052857-4	2002	Since one of the phosphorylation sites lies within the Cln2 PEST motif, a sequence rich in proline, aspartate or glutamate, serine, and threonine residues found in many unstable proteins, we fused various Cln2 C-terminal domains containing combinations of the PEST and the phosphoacceptor motifs to stable reporter proteins.	Aspartic Acid	100-109	cyclin CLN2	Saccharomyces cerevisiae S288C	55-59
12139236-2	2002	There are at least two known alleles of MIC-1 that are due to a G--&gt;C point substitution at position 6 of the mature protein, which alters a histidine to an aspartic acid (MIC-1 H and MIC-1 D).	Aspartic Acid	160-173	growth differentiation factor 15	Homo sapiens	40-45
12084073-0	2002	Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues.	Aspartic Acid	18-27	solute carrier family 25 member 12	Rattus norvegicus	61-68
12184737-4	2002	When external Cl- was replaced by other anions, the [Ca2+]i increase mediated by the P2Y2 receptor was not changed, but that mediated by the P2X7 receptor varied in the order of aspartate- &gt; methanesulfonate &gt; Cl- &gt; Br &gt; or = I-.	Aspartic Acid	178-187	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	141-154
12212724-5	2002	The activities of the glycolytic enzymes glucose-6-phosphate dehydrogenase (G6PD) for the pentose phosphate pathway and malate dehydrogenase (MDH) for the malate-aspartate shuttle, and the expression of the mRNA of cytosolic MDH were significantly increased in the testicular tissues of dogs with seminoma.	Aspartic Acid	162-171	glucose-6-phosphate dehydrogenase	Canis lupus familiaris	76-80
12134089-5	2002	Analysis of deletion mutants of EGFR showed that the region between (835)Ala and (918)Asp of the EGFR cytoplasmic domain is required for EGFR predimer formation.	Aspartic Acid	86-89	epidermal growth factor receptor	Homo sapiens	32-36
12134089-5	2002	Analysis of deletion mutants of EGFR showed that the region between (835)Ala and (918)Asp of the EGFR cytoplasmic domain is required for EGFR predimer formation.	Aspartic Acid	86-89	epidermal growth factor receptor	Homo sapiens	97-101
12134089-5	2002	Analysis of deletion mutants of EGFR showed that the region between (835)Ala and (918)Asp of the EGFR cytoplasmic domain is required for EGFR predimer formation.	Aspartic Acid	86-89	epidermal growth factor receptor	Homo sapiens	97-101
12082127-4	2002	It has been proposed that this species specificity of the hGHR is largely caused by the Leu --&gt; Arg change at position 43 after a prior His --&gt; Asp change at position 171 of the GH.	Aspartic Acid	150-153	growth hormone receptor	Homo sapiens	58-62
12224762-9	2002	The results suggest that cadmium effects on plasma prolactin levels may be partially explained by the changes in aspartate, glutamate or taurine contents, but not by the decrease in GABA content in the brain regions studied.	Aspartic Acid	113-122	prolactin	Rattus norvegicus	51-60
12135563-1	2002	Enterokinase (EC 3.4.21.9) is a serine proteinase in the duodenum that exhibits specificity for the sequence (Asp)(4)-Lys.	Aspartic Acid	110-113	transmembrane serine protease 15	Bos taurus	0-12
12069594-4	2002	Similar to wild-type neuropeptide Y (NPY) and [Ala(31), Aib(32)]-NPY, the N-terminal residues Tyr(1)-Asp(16) are disordered in solution.	Aspartic Acid	101-104	neuropeptide Y	Homo sapiens	37-40
12006574-6	2002	Consistent with the need for the interaction between Arg(2) of Ang II and Ang III with Asp(281), substitution of this residue with alanine (D281A) decreased the peptide"s potency without affecting that of Ang IV.	Aspartic Acid	87-90	angiotensinogen	Homo sapiens	63-69
12006574-6	2002	Consistent with the need for the interaction between Arg(2) of Ang II and Ang III with Asp(281), substitution of this residue with alanine (D281A) decreased the peptide"s potency without affecting that of Ang IV.	Aspartic Acid	87-90	angiogenin	Homo sapiens	63-66
12006574-6	2002	Consistent with the need for the interaction between Arg(2) of Ang II and Ang III with Asp(281), substitution of this residue with alanine (D281A) decreased the peptide"s potency without affecting that of Ang IV.	Aspartic Acid	87-90	angiogenin	Homo sapiens	74-77
12069578-7	2002	Analysis of combinations of point mutations reveals that Asp-173 in the epsilon subunit is required together with the remaining determinants in the epsilon subunit to achieve Wtx-1 selectivity.	Aspartic Acid	57-60	APC membrane recruitment protein 1	Homo sapiens	175-178
11907033-8	2002	Distinct from the Na(+)-independent cystine/glutamate transporter xCT structurally related to AGT1, AGT1 did not accept cystine, homocysteate, and l-alpha-aminoadipate and exhibited high affinity to aspartate as well as glutamate, suggesting that the negative charge recognition site in the side chain-binding site of AGT1 would be closer to the alpha-carbon binding site compared with that of xCT.	Aspartic Acid	199-208	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	Mus musculus	100-104
12070348-0	2002	The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.	Aspartic Acid	4-13	presenilin 1	Mus musculus	21-33
12070348-0	2002	The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.	Aspartic Acid	4-13	catenin (cadherin associated protein), beta 1	Mus musculus	121-133
11934898-9	2002	Mutations of residues Asp170 and Asp172 abrogated Fcp1 phosphatase activity; the essential aspartates are located within a 170DXDXT172 motif that defines a superfamily of metal-dependent phosphotransferases.	Aspartic Acid	91-101	protein serine/threonine phosphatase	Saccharomyces cerevisiae S288C	50-54
11919182-6	2002	Here we report that sequences between residues Ala(176) and Asp(275) of paxillin are sufficient for binding to the alpha(4) tail.	Aspartic Acid	60-63	paxillin	Homo sapiens	72-80
11956211-5	2002	In vitro binding assays demonstrate dose-dependent binding of PKC epsilon to RACK1 which is inhibited by an 8-amino acid peptide based on the sequence of the sixth Trp-Asp repeat in RACK1 or by an 8-amino acid sequence in the V1 region of PKC epsilon, epsilon V1-2.	Aspartic Acid	168-171	protein kinase C epsilon	Homo sapiens	62-73
11956211-5	2002	In vitro binding assays demonstrate dose-dependent binding of PKC epsilon to RACK1 which is inhibited by an 8-amino acid peptide based on the sequence of the sixth Trp-Asp repeat in RACK1 or by an 8-amino acid sequence in the V1 region of PKC epsilon, epsilon V1-2.	Aspartic Acid	168-171	receptor for activated C kinase 1	Homo sapiens	77-82
11956211-5	2002	In vitro binding assays demonstrate dose-dependent binding of PKC epsilon to RACK1 which is inhibited by an 8-amino acid peptide based on the sequence of the sixth Trp-Asp repeat in RACK1 or by an 8-amino acid sequence in the V1 region of PKC epsilon, epsilon V1-2.	Aspartic Acid	168-171	receptor for activated C kinase 1	Homo sapiens	182-187
11919182-7	2002	We found that the alpha(4) tail, paxillin, and FAT, the focal adhesion targeting domain of pp125(FAK), could form a ternary complex and that the alpha(4)-binding paxillin fragment, P(Ala(176)-Asp(275)), specifically blocked paxillin binding to the alpha(4) tail more efficiently than it blocked binding to FAT.	Aspartic Acid	192-195	paxillin	Homo sapiens	162-170
11907033-8	2002	Distinct from the Na(+)-independent cystine/glutamate transporter xCT structurally related to AGT1, AGT1 did not accept cystine, homocysteate, and l-alpha-aminoadipate and exhibited high affinity to aspartate as well as glutamate, suggesting that the negative charge recognition site in the side chain-binding site of AGT1 would be closer to the alpha-carbon binding site compared with that of xCT.	Aspartic Acid	199-208	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	Mus musculus	100-104
11919182-7	2002	We found that the alpha(4) tail, paxillin, and FAT, the focal adhesion targeting domain of pp125(FAK), could form a ternary complex and that the alpha(4)-binding paxillin fragment, P(Ala(176)-Asp(275)), specifically blocked paxillin binding to the alpha(4) tail more efficiently than it blocked binding to FAT.	Aspartic Acid	192-195	paxillin	Homo sapiens	162-170
11925440-1	2002	Factor Xa (FXa) hydrolyzes two peptide bonds in prothrombin having (Glu/Asp)-Gly-Arg-(Thr/Ile) for P(3)-P(2)-P(1)-P(1)" residues, but the exact preferences of its catalytic groove remain largely unknown.	Aspartic Acid	72-75	coagulation factor X	Homo sapiens	0-9
11925440-1	2002	Factor Xa (FXa) hydrolyzes two peptide bonds in prothrombin having (Glu/Asp)-Gly-Arg-(Thr/Ile) for P(3)-P(2)-P(1)-P(1)" residues, but the exact preferences of its catalytic groove remain largely unknown.	Aspartic Acid	72-75	coagulation factor X	Homo sapiens	11-14
12391724-2	2002	Sequence analysis predicts that the UBH1 cDNA encodes a 355 amino acid polypeptide with the molecular weight of approximately 39 kDa containing the highly conserved Cys, Asp, and His domains characteristic of the ubiquitin-specific processing proteases.	Aspartic Acid	170-173	ubiquitin specific peptidase 12	Mus musculus	36-40
12010932-2	2002	OBJECTIVE: To assess whether Glu298--&gt;Asp polymorphism of the eNOS gene is associated with the occurrence and severity of angiographically defined coronary artery disease in the Italian population.	Aspartic Acid	41-44	nitric oxide synthase 3	Homo sapiens	65-69
12031901-7	2002	The detection of glyoxylic acid and CO(2)(-*) from Asp demonstrates the occurrence of competing beta-scission processes for the Asp C-3 alkoxyl radical.	Aspartic Acid	51-54	complement C3	Homo sapiens	132-135
12010932-3	2002	METHODS: Polymerase chain reaction/restriction fragment length polymorphism analysis was done to detect the Glu298--&gt;Asp variant of the eNOS gene in 201 patients with coronary artery disease and 114 controls.	Aspartic Acid	120-123	nitric oxide synthase 3	Homo sapiens	139-143
12010932-6	2002	In comparison with subjects who had a Glu298 allele in the eNOS gene, the risk of coronary artery disease was increased among Asp/Asp carriers (odds ratio 2.9, 95% confidence interval 1.2 to 6.8, p = 0.01) and was independent of the other common risk factors (p = 0.04).	Aspartic Acid	126-129	nitric oxide synthase 3	Homo sapiens	59-63
12010932-6	2002	In comparison with subjects who had a Glu298 allele in the eNOS gene, the risk of coronary artery disease was increased among Asp/Asp carriers (odds ratio 2.9, 95% confidence interval 1.2 to 6.8, p = 0.01) and was independent of the other common risk factors (p = 0.04).	Aspartic Acid	130-133	nitric oxide synthase 3	Homo sapiens	59-63
12010932-8	2002	CONCLUSIONS: Glu298--&gt;Asp polymorphism of the eNOS gene appears to be associated with the presence, extent, and severity of angiographically assessed coronary artery disease.	Aspartic Acid	25-28	nitric oxide synthase 3	Homo sapiens	49-53
12069902-7	2002	Point mutations were created to exchange the histidine and aspartate residues of the alpha1 and alpha5 subunits.	Aspartic Acid	59-68	adrenoceptor alpha 1D	Homo sapiens	85-91
11901152-9	2002	In addition to Arg-142, we found that Glu-139 and Asp-143 of human ADA are also important for CD26 binding.	Aspartic Acid	50-53	adenosine deaminase	Homo sapiens	67-70
11901152-9	2002	In addition to Arg-142, we found that Glu-139 and Asp-143 of human ADA are also important for CD26 binding.	Aspartic Acid	50-53	dipeptidyl peptidase 4	Homo sapiens	94-98
11919192-4	2002	Inhibition of caspase-9 with either the peptide inhibitor benzyloxycarbonyl-Leu-Glu(OCH(3))-His-Asp(OCH(3))-fluoromethyl ketone, or expression of a catalytically inactive caspase-9 by retroviral transduction, protected normal keratinocytes from UV-induced apoptosis.	Aspartic Acid	96-99	caspase 9	Homo sapiens	14-23
11864984-2	2002	Potential insight into the coupling mechanism was provided by our previous finding that mutation to Lys of a single residue (Asp(540)) located in the S4-S5 linker endowed HERG (human ether-a-go-go-related gene) K(+) channels with the unusual ability to open in response to membrane depolarization and hyperpolarization in a voltage-dependent manner.	Aspartic Acid	125-128	potassium voltage-gated channel subfamily H member 2	Homo sapiens	171-175
11896059-10	2002	The data also reveal a DXD-like motif in LH3 characteristic of many glycosyltransferases and the mutagenesis of aspartates of this motif eliminated the GGT activity.	Aspartic Acid	112-122	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	41-44
12173071-2	2002	The mutation results in an exchange of aspartic acid into a glycine of the amino acid 294 of PKCalpha, which is located adjacent to the Ca (2+)-binding hinge region and has been proposed as an activation inhibitor.	Aspartic Acid	39-52	protein kinase C alpha	Homo sapiens	93-101
12015360-5	2002	Medullary and pontine NR1 expression correlated with baseline ventilation and magnitude of the ventilatory response to aspartic acid in some groups.	Aspartic Acid	119-132	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	22-25
12015360-6	2002	Thus 1) tidal volume and breathing frequency patterns in response to aspartic acid are gender, age, and treatment dependent; 2) sex, age, and exogenous steroid hormones affect NR1 expression primarily in the hypothalamus; and 3) there is correlation between NR1 expression in pons and medulla with ventilatory parameters.	Aspartic Acid	69-82	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	176-179
12023363-7	2002	The codons determining the isotype, Asp(1054), Leu(1101), Ser(1102), Ile(1105) and His(1106), were characteristic of C4B gene, whereas the polymorphic sites in exon and intron 28 were indicative of C4A3a sequence.	Aspartic Acid	36-39	complement C4B (Chido blood group)	Homo sapiens	117-120
12134953-12	2002	Arg-Gly and Arg-Gly-Asp were found to be direct substrates for iNOS with similar Km and Vmax values to those of Arg.	Aspartic Acid	20-23	nitric oxide synthase 2	Rattus norvegicus	63-67
12068109-7	2002	For aat2-2, this growth defect is exaggerated by Asp supplementation, suggesting a defect in Asp metabolism.	Aspartic Acid	49-52	aspartate aminotransferase 2	Arabidopsis thaliana	4-8
12068109-7	2002	For aat2-2, this growth defect is exaggerated by Asp supplementation, suggesting a defect in Asp metabolism.	Aspartic Acid	93-96	aspartate aminotransferase 2	Arabidopsis thaliana	4-8
12068109-8	2002	Amino acid analysis of the aat mutants showed alterations in levels of Asp and/or Asp-derived amino acids in several aat2 alleles.	Aspartic Acid	71-74	aspartate aminotransferase 2	Arabidopsis thaliana	117-121
12068109-8	2002	Amino acid analysis of the aat mutants showed alterations in levels of Asp and/or Asp-derived amino acids in several aat2 alleles.	Aspartic Acid	82-85	aspartate aminotransferase 2	Arabidopsis thaliana	117-121
12068109-9	2002	Two aat2 mutants show dramatic decreases in Asp and asparagine levels in leaves and/or siliques.	Aspartic Acid	44-47	aspartate aminotransferase 2	Arabidopsis thaliana	4-8
12068109-10	2002	As such, the cytosolic AAT2 isoenzyme appears to serve a nonredundant function in plant nitrogen metabolism of Asp and Asp-derived amino acids.	Aspartic Acid	111-114	aspartate aminotransferase 2	Arabidopsis thaliana	23-27
11856753-0	2002	Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote intramolecular interactions during glycosaminoglycan binding and thrombin inhibition.	Aspartic Acid	0-13	serpin family D member 1	Homo sapiens	60-79
11856753-0	2002	Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote intramolecular interactions during glycosaminoglycan binding and thrombin inhibition.	Aspartic Acid	0-13	coagulation factor II, thrombin	Homo sapiens	153-161
11912188-4	2002	Transfection experiments with hsp27 mutants in which specific serine phosphorylation residues (Ser(78) and Ser(82)) were substituted with alanines or aspartic acids showed that phosphorylation of HSP27 is accompanied by its nuclear translocation.	Aspartic Acid	150-164	heat shock protein family B (small) member 1	Homo sapiens	196-201
11912188-8	2002	In addition, actin filament was more stable in Asp(78,82)-hsp27 (mimics the phosphorylated form) transfected HiB5 cells than in the normal and Ala(78,82)-hsp27 (nonphosphorylative form) transfected cells.	Aspartic Acid	47-50	heat shock protein family B (small) member 1	Homo sapiens	58-63
11912188-9	2002	In accordance with actin filament stability, the survival rate against the heat shock increased markedly in Asp(15,78,82)-hsp27 expressing HiB5 cells but decreased in Ala(15,78,82)-hsp27 expressing cells.	Aspartic Acid	108-111	heat shock protein family B (small) member 1	Homo sapiens	122-127
12051922-1	2002	There exists a d-enantiomer of aspartic acid in lactic acid bacteria and several hyperthermophilic archaea, which is biosynthesized from the l-enantiomer by aspartate racemase.	Aspartic Acid	31-44	aspartate/glutamate racemase family protein	Pyrococcus horikoshii OT3	157-175
11880366-4	2002	These analyses ultimately identified Asp(149), Arg(151), Gly(207), Tyr(252), and Glu(258) as critical for NIF binding.	Aspartic Acid	37-40	S100 calcium binding protein A8	Homo sapiens	106-109
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Aspartic Acid	71-74	DnaJ	Escherichia coli	84-88
12054669-5	2002	Hsc56 contains the -His-Pro-Glu- sequence corresponding to the His-Pro-Asp motif in DnaJ, which is indispensable for DnaJ to interact with DnaK.	Aspartic Acid	71-74	DnaJ	Escherichia coli	117-121
11867621-0	2002	Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2.	Aspartic Acid	0-13	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	55-102
11867621-0	2002	Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2.	Aspartic Acid	0-13	arrestin beta 1	Homo sapiens	163-172
11867621-11	2002	Unlike other GPCRs that additionally require receptor phosphorylation, LH/CG R activation is sufficient to expose a conformation in which Asp-564 in the 3i loop confers high affinity binding selectively to arrestin2.	Aspartic Acid	138-141	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	71-78
11867621-11	2002	Unlike other GPCRs that additionally require receptor phosphorylation, LH/CG R activation is sufficient to expose a conformation in which Asp-564 in the 3i loop confers high affinity binding selectively to arrestin2.	Aspartic Acid	138-141	arrestin beta 1	Homo sapiens	206-215
12062043-4	2002	Replacement of SNAP-25 in PC12 cells with SNAP-25 containing C-terminal Asp mutations led to a loss-of-function in regulated exocytosis at the Ca2+-dependent fusion step.	Aspartic Acid	72-75	synaptosome associated protein 25	Rattus norvegicus	42-49
11994017-9	2002	Screening of the pY library against the catalytic domain of SHP-1 revealed that SHP-1 prefers an acidic residue at the -2 position, with aspartic acid being slightly better than glutamic acid.	Aspartic Acid	137-150	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	60-65
11861643-6	2002	Asp-132 in MAO A (Asp-123 in MAO B) located at the entrance of the U-shaped substrate-binding site has no effect on MAO A nor MAO B catalytic activity.	Aspartic Acid	0-3	monoamine oxidase A	Homo sapiens	11-16
11861643-6	2002	Asp-132 in MAO A (Asp-123 in MAO B) located at the entrance of the U-shaped substrate-binding site has no effect on MAO A nor MAO B catalytic activity.	Aspartic Acid	0-3	monoamine oxidase B	Homo sapiens	29-34
11861643-6	2002	Asp-132 in MAO A (Asp-123 in MAO B) located at the entrance of the U-shaped substrate-binding site has no effect on MAO A nor MAO B catalytic activity.	Aspartic Acid	18-21	monoamine oxidase A	Homo sapiens	11-16
11861643-6	2002	Asp-132 in MAO A (Asp-123 in MAO B) located at the entrance of the U-shaped substrate-binding site has no effect on MAO A nor MAO B catalytic activity.	Aspartic Acid	18-21	monoamine oxidase B	Homo sapiens	29-34
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Aspartic Acid	128-131	response regulator 4	Arabidopsis thaliana	12-16
11859082-5	2002	Removal of Asp(64) and His(187), which are involved in stabilization of the cationic sugar and the anionic uracil leaving group, respectively, specifically weakens binding of I to the UDG-uracil complex by 154,000-fold, without significantly affecting substrate or product binding.	Aspartic Acid	11-14	uracil DNA glycosylase	Homo sapiens	184-187
11875078-5	2002	Here, we demonstrate that human RAD21 is preferentially cleaved at Asp(279) by caspases-3 and -7 in vitro to generate two major proteolytic products of approximately 65 and 48 kDa.	Aspartic Acid	67-70	RAD21 cohesin complex component	Homo sapiens	32-37
11875078-5	2002	Here, we demonstrate that human RAD21 is preferentially cleaved at Asp(279) by caspases-3 and -7 in vitro to generate two major proteolytic products of approximately 65 and 48 kDa.	Aspartic Acid	67-70	caspase 3	Homo sapiens	79-96
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Aspartic Acid	128-131	response regulator 4	Arabidopsis thaliana	17-22
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Aspartic Acid	128-131	response regulator 4	Arabidopsis thaliana	23-27
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Aspartic Acid	128-131	response regulator 3	Arabidopsis thaliana	32-36
12054542-1	2002	Arabidopsis ARR4/ATRR1/IBC7 and ARR8/ATRR3 are homologous genes of prokaryotic response regulators that are involved in the His-Asp phosphorelay signal transduction.	Aspartic Acid	128-131	response regulator 3	Arabidopsis thaliana	37-42
11962665-2	2002	In the results of X-ray diffraction analysis, HAp synthesized in the presence of glycine (HAp-Gly), serine (HAp-Ser), aspartic acid (HAp-Asp) and glutamic acid (HAp-Glu) showed poor crystallinity compared with HAp synthesized in the absence of amino acid (HAp-con).	Aspartic Acid	118-131	reticulon 3	Homo sapiens	46-49
12000740-6	2002	Mutational analysis revealed that caspase-mediated cleavage of GCLC occurs at Asp(499) within the sequence AVVD(499)G. GCLC cleavage occurs upstream of Cys(553), which is thought to be important for association with GCLM.	Aspartic Acid	78-81	glutamate-cysteine ligase catalytic subunit	Homo sapiens	63-67
12009947-1	2002	Three amino acids residues, Arg-Gly-Asp (RGD), in vitronectin and fibronectin show affinity for alpha(V)beta(3) integrins expressed in vascular endothelial cells.	Aspartic Acid	36-39	vitronectin	Homo sapiens	50-61
11962665-2	2002	In the results of X-ray diffraction analysis, HAp synthesized in the presence of glycine (HAp-Gly), serine (HAp-Ser), aspartic acid (HAp-Asp) and glutamic acid (HAp-Glu) showed poor crystallinity compared with HAp synthesized in the absence of amino acid (HAp-con).	Aspartic Acid	137-140	reticulon 3	Homo sapiens	46-49
12144064-0	2002	Double heterozygosity for Hb Pyrgos [beta83(EF7)Gly-->Asp] and Hb E [beta26(B8)Glu-->Lys] found in association with alpha-thalassemia.	Aspartic Acid	54-57	FAM3 metabolism regulating signaling molecule D	Homo sapiens	44-47
11978727-3	2002	Based on sequence analysis, Png1p was classified as a member of the "transglutaminase-like superfamily" that contains a putative catalytic triad of amino acids (cysteine, histidine, and aspartic acid).	Aspartic Acid	186-199	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase	Saccharomyces cerevisiae S288C	28-33
12432277-3	2002	In this study, we investigated the impact of Asp substitution at Thrl8 and Ser20 (p53Tl8D/S20D) on the functional regulation of p53.	Aspartic Acid	45-48	tumor protein p53	Homo sapiens	82-85
12009776-0	2002	Protein kinase C regulates [3H]D-aspartate release in auditory brain stem nuclei.	Aspartic Acid	33-42	proline rich transmembrane protein 2	Homo sapiens	0-16
12009776-2	2002	To determine if this release activity could be regulated by protein kinase C (PKC), which has been associated with regulation of transmitter release, the electrically evoked release of [3H]d-aspartate ([3H]d-Asp) was quantified in vitro as an index of exocytosis from glutamatergic presynaptic endings in the major subdivisions of the cochlear nucleus (CN) and in the main nuclei of the superior olivary complex (SOC).	Aspartic Acid	191-200	proline rich transmembrane protein 2	Homo sapiens	60-76
12009776-2	2002	To determine if this release activity could be regulated by protein kinase C (PKC), which has been associated with regulation of transmitter release, the electrically evoked release of [3H]d-aspartate ([3H]d-Asp) was quantified in vitro as an index of exocytosis from glutamatergic presynaptic endings in the major subdivisions of the cochlear nucleus (CN) and in the main nuclei of the superior olivary complex (SOC).	Aspartic Acid	191-200	proline rich transmembrane protein 2	Homo sapiens	78-81
12009776-2	2002	To determine if this release activity could be regulated by protein kinase C (PKC), which has been associated with regulation of transmitter release, the electrically evoked release of [3H]d-aspartate ([3H]d-Asp) was quantified in vitro as an index of exocytosis from glutamatergic presynaptic endings in the major subdivisions of the cochlear nucleus (CN) and in the main nuclei of the superior olivary complex (SOC).	Aspartic Acid	208-211	proline rich transmembrane protein 2	Homo sapiens	60-76
12009776-2	2002	To determine if this release activity could be regulated by protein kinase C (PKC), which has been associated with regulation of transmitter release, the electrically evoked release of [3H]d-aspartate ([3H]d-Asp) was quantified in vitro as an index of exocytosis from glutamatergic presynaptic endings in the major subdivisions of the cochlear nucleus (CN) and in the main nuclei of the superior olivary complex (SOC).	Aspartic Acid	208-211	proline rich transmembrane protein 2	Homo sapiens	78-81
11825902-4	2002	Western blot analyses of degradation products of overexpressed green fluorescence protein-tagged paxillin and site-specific mutants demonstrated that Asp-102 and Asp-301 were early caspase cleavage sites, and Asp-5, Asp-146, Asp-165, and Asp-222 were late cleavage sites.	Aspartic Acid	150-153	paxillin	Mus musculus	97-105
11960969-2	2002	A microdialysis experiment showed that microinjection of angiotensin II into the RVLM significantly (P &lt; 0.01) increased the release of aspartate and glutamate in the intermediolateral column of the spinal cord.	Aspartic Acid	139-148	angiotensinogen	Rattus norvegicus	57-71
11825902-4	2002	Western blot analyses of degradation products of overexpressed green fluorescence protein-tagged paxillin and site-specific mutants demonstrated that Asp-102 and Asp-301 were early caspase cleavage sites, and Asp-5, Asp-146, Asp-165, and Asp-222 were late cleavage sites.	Aspartic Acid	162-165	paxillin	Mus musculus	97-105
11825902-4	2002	Western blot analyses of degradation products of overexpressed green fluorescence protein-tagged paxillin and site-specific mutants demonstrated that Asp-102 and Asp-301 were early caspase cleavage sites, and Asp-5, Asp-146, Asp-165, and Asp-222 were late cleavage sites.	Aspartic Acid	162-165	paxillin	Mus musculus	97-105
11825902-4	2002	Western blot analyses of degradation products of overexpressed green fluorescence protein-tagged paxillin and site-specific mutants demonstrated that Asp-102 and Asp-301 were early caspase cleavage sites, and Asp-5, Asp-146, Asp-165, and Asp-222 were late cleavage sites.	Aspartic Acid	162-165	paxillin	Mus musculus	97-105
11825902-4	2002	Western blot analyses of degradation products of overexpressed green fluorescence protein-tagged paxillin and site-specific mutants demonstrated that Asp-102 and Asp-301 were early caspase cleavage sites, and Asp-5, Asp-146, Asp-165, and Asp-222 were late cleavage sites.	Aspartic Acid	162-165	paxillin	Mus musculus	97-105
11825902-6	2002	Furthermore, this anti-apoptotic effect of paxillin was augmented by a triple mutation in aspartic acids at caspase cleavage sites.	Aspartic Acid	90-104	paxillin	Mus musculus	43-51
11976690-5	2002	Key contacts are described between the GoLoco motif and Galpha protein, including the extension of GoLoco"s highly conserved Asp/Glu-Gln-Arg triad into the nucleotide-binding pocket of Galpha to make direct contact with the GDP alpha- and beta-phosphates.	Aspartic Acid	125-128	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	56-62
11976690-5	2002	Key contacts are described between the GoLoco motif and Galpha protein, including the extension of GoLoco"s highly conserved Asp/Glu-Gln-Arg triad into the nucleotide-binding pocket of Galpha to make direct contact with the GDP alpha- and beta-phosphates.	Aspartic Acid	125-128	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	185-191
12062402-2	2002	Thiolsubtilisin, a chemically modified enzyme that has a catalytic triad of Cys-His-Asp at the active site, mimics the catalysis of arylamine N-acetyltransferase, serotonin N-acetyltransferase, histone N-acetyltransferase and amino acid N-acetyltransferase.	Aspartic Acid	84-87	aralkylamine N-acetyltransferase	Homo sapiens	163-192
12062406-6	2002	Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes.	Aspartic Acid	52-55	fibrinogen beta chain	Homo sapiens	73-83
12062406-6	2002	Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes.	Aspartic Acid	52-55	fibrinogen beta chain	Homo sapiens	151-161
11953320-6	2002	Mutation of Ser120 to threonine or alanine abolished hHR6A activity, while mutation to aspartate to mimic phosphorylated serine increased hHR6A activity 3-fold.	Aspartic Acid	87-96	ubiquitin conjugating enzyme E2 A	Homo sapiens	138-143
11925101-4	2002	However, since these initial reports, several studies using aspartate-813 mutants (D813) have demonstrated the ability of kinase-impaired ErbB receptors to induce mitogenic signal transduction pathways and cell transformation in a ligand-dependent manner.	Aspartic Acid	60-69	epidermal growth factor receptor	Homo sapiens	138-142
11812789-4	2002	Cys-191, His-218, and Asp-235 of Png1p are conserved in the sequence of factor XIIIa, where these amino acids constitute a catalytic triad.	Aspartic Acid	22-25	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase	Saccharomyces cerevisiae S288C	33-38
11773073-8	2002	In this work, beta-hydroxylation of Asp residues in EGF domains is demonstrated for a soluble form of a Notch ligand, human Jagged-1.	Aspartic Acid	36-39	jagged canonical Notch ligand 1	Homo sapiens	124-132
11922623-5	2002	Comparison of the computed structure of pro-BACE with X-ray structures of pepsinogen and progastricsin (two other pro-aspartyl proteases) reveals a significant difference in the relationship of the pro-segment to the catalytic aspartates.	Aspartic Acid	227-237	beta-secretase 1	Homo sapiens	44-48
11922623-5	2002	Comparison of the computed structure of pro-BACE with X-ray structures of pepsinogen and progastricsin (two other pro-aspartyl proteases) reveals a significant difference in the relationship of the pro-segment to the catalytic aspartates.	Aspartic Acid	227-237	progastricsin	Homo sapiens	89-102
11922623-6	2002	In both pepsinogen and progastricsin a lysine side-chain in the pro-segment forms a salt bridge to the two catalytic aspartates, occupying the position normally occupied by a catalytic water.	Aspartic Acid	117-127	progastricsin	Homo sapiens	23-36
11884718-3	2002	Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence.	Aspartic Acid	146-149	integrin subunit alpha V	Homo sapiens	69-89
11799105-3	2002	The three-dimensional structure of NAT from Salmonella typhimurium has been resolved and shown to have three distinct domains and an active site catalytic triad composed of "Cys(69)-His(107)-Asp(122)," which is typical of hydrolytic enzymes such as the cysteine proteases.	Aspartic Acid	191-194	bromodomain containing 2	Homo sapiens	35-38
11884718-6	2002	The tertiary rearrangements take place in betaA, the ligand-binding domain of beta3; in the complex, betaA acquires two cations, one of which contacts the ligand Asp directly and the other stabilizes the ligand-binding surface.	Aspartic Acid	162-165	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	78-83
11930008-2	2002	Osteopontin (OPN) is an extracellular matrix protein containing Arg-Gly-Asp (RGD) sequence, which interacts with alpha(v)beta3 integrins, promotes cell attachment, and cell migration and is expressed in both synovial cells and chondrocytes in rheumatoid arthritis; however, its functional relationship to arthritis has not been known.	Aspartic Acid	72-75	secreted phosphoprotein 1	Mus musculus	0-11
11917124-0	2002	Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.	Aspartic Acid	90-103	leukotriene A4 hydrolase	Homo sapiens	0-24
11917124-3	2002	From the crystal structure of LTA4H, a hydrophilic patch composed of Gln-134, Tyr-267, and Asp-375 was identified in a narrow and otherwise hydrophobic pocket, believed to bind LTA4.	Aspartic Acid	91-94	leukotriene A4 hydrolase	Homo sapiens	30-35
11917124-5	2002	In the present report we used site-directed mutagenesis and x-ray crystallography to show that Asp-375, but none of the other candidate residues, is specifically required for the epoxide hydrolase activity of LTA4H.	Aspartic Acid	95-98	leukotriene A4 hydrolase	Homo sapiens	209-214
11930008-2	2002	Osteopontin (OPN) is an extracellular matrix protein containing Arg-Gly-Asp (RGD) sequence, which interacts with alpha(v)beta3 integrins, promotes cell attachment, and cell migration and is expressed in both synovial cells and chondrocytes in rheumatoid arthritis; however, its functional relationship to arthritis has not been known.	Aspartic Acid	72-75	secreted phosphoprotein 1	Mus musculus	13-16
11917124-6	2002	Thus, mutation of Asp-375 leads to a selective loss of the enzyme"s ability to generate LTB4 whereas the aminopeptidase activity is preserved.	Aspartic Acid	18-21	carboxypeptidase Q	Homo sapiens	105-119
12021143-3	2002	HLA genotyping identified several polymorphic residues of the DQalpha and DQbeta to be either positively or negatively associated with IDDM, including Arg 52 DQalpha and Asp 57 DQbeta.	Aspartic Acid	170-173	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	0-3
12047225-6	2002	Sequencing of the CSTB alleles showed a missense mutation that changes a codon for aspartic acid into a codon for asparagine in exon 3 of the gene.	Aspartic Acid	83-96	cystatin B	Sus scrofa	18-22
11880255-0	2002	Role of aspartate residues in Ca(2+) affinity and permeation of the distal ECaC1.	Aspartic Acid	8-17	transient receptor potential cation channel, subfamily V, member 5 L homeolog	Xenopus laevis	75-80
12021143-3	2002	HLA genotyping identified several polymorphic residues of the DQalpha and DQbeta to be either positively or negatively associated with IDDM, including Arg 52 DQalpha and Asp 57 DQbeta.	Aspartic Acid	170-173	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	74-80
12021143-3	2002	HLA genotyping identified several polymorphic residues of the DQalpha and DQbeta to be either positively or negatively associated with IDDM, including Arg 52 DQalpha and Asp 57 DQbeta.	Aspartic Acid	170-173	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	177-183
11983426-11	2002	The enzyme also cleaved an N-terminal synthetic peptide of bovine annexin II (Gly(24)-Ser-Val-Lys-Ala-Tyr-Thr(30)-Asn-Phe-Asp-Ala-Glu(35)-Arg-Asp(37)) at a position between Asn(31) and Phe(32).	Aspartic Acid	122-125	annexin A2	Bos taurus	66-76
11983426-11	2002	The enzyme also cleaved an N-terminal synthetic peptide of bovine annexin II (Gly(24)-Ser-Val-Lys-Ala-Tyr-Thr(30)-Asn-Phe-Asp-Ala-Glu(35)-Arg-Asp(37)) at a position between Asn(31) and Phe(32).	Aspartic Acid	142-145	annexin A2	Bos taurus	66-76
11972751-6	2002	In the positions with aliphatic amino acids, substitution by tyrosine or phenylalanine, and in the positions with charged amino acids, substitution by aspartic acid or lysine, preserved the affinity to FVIII.	Aspartic Acid	151-164	coagulation factor VIII	Homo sapiens	202-207
11948059-11	2002	The mean serum angiotensin-converting enzyme (S-ACE) value was higher in the AcP group than in the AsP group (p &lt; 0.02).	Aspartic Acid	99-102	angiotensin I converting enzyme	Homo sapiens	15-44
12455952-2	2002	Sln1p consists of a sensor kinase module that undergoes histidine autophosphorylation and a receiver module that autocatalytically transfers the phosphoryl group from histidine to aspartate.	Aspartic Acid	180-189	histidine kinase	Saccharomyces cerevisiae S288C	0-5
12455952-3	2002	The Sln1p aspartyl phosphate is then transferred to Ypd1p, which in turn transfers the phosphoryl group to a conserved aspartate on one of two response regulators, Ssk1p and Skn7p.	Aspartic Acid	119-128	histidine kinase	Saccharomyces cerevisiae S288C	4-9
12455952-3	2002	The Sln1p aspartyl phosphate is then transferred to Ypd1p, which in turn transfers the phosphoryl group to a conserved aspartate on one of two response regulators, Ssk1p and Skn7p.	Aspartic Acid	119-128	Ypd1p	Saccharomyces cerevisiae S288C	52-57
12455952-3	2002	The Sln1p aspartyl phosphate is then transferred to Ypd1p, which in turn transfers the phosphoryl group to a conserved aspartate on one of two response regulators, Ssk1p and Skn7p.	Aspartic Acid	119-128	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	164-169
12455952-3	2002	The Sln1p aspartyl phosphate is then transferred to Ypd1p, which in turn transfers the phosphoryl group to a conserved aspartate on one of two response regulators, Ssk1p and Skn7p.	Aspartic Acid	119-128	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	174-179
12297037-1	2002	Replacement of the Asp-84 residue of the deoxyguanosine kinase subunit of the tandem deoxyadenosine kinase/ deoxyguanosine kinase (dAK/dGK) from Lactobacillus acidophilus R-26 by Ala, Asn, or Glu produced increased Km values for deoxyguanosine on dGK.	Aspartic Acid	19-22	Diacyl glycerol kinase	Drosophila melanogaster	135-138
11985794-0	2002	Tumor necrosis factor alpha-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors.	Aspartic Acid	95-98	tumor necrosis factor	Mus musculus	0-27
11821146-3	2002	Treatment of the cells with insulin-like growth factor-1 but not epidermal growth factor or neuronal growth factor, induces a dose and time dependent increase in [(3)H]-D-aspartate uptake that is sensitive to wortmannin, an inhibitor of phosphatidylinositol 3-kinase.	Aspartic Acid	171-180	insulin like growth factor 1	Gallus gallus	28-56
11751897-4	2002	We find that GluR1, but not GluR2 or GluR3, is a substrate for agonist (alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid)-initiated rapid proteolytic cleavage at aspartic acid 865 through the activation of caspase 8-like activity that is independent of membrane fusion and is not coincident with apoptosis.	Aspartic Acid	171-184	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	13-18
11788583-4	2002	Transfection of K8 Ser-73 --&gt; Ala or K8 Ser-73 --&gt; Asp with K18 generates normal-appearing filaments.	Aspartic Acid	57-60	keratin 8	Homo sapiens	16-18
11788583-4	2002	Transfection of K8 Ser-73 --&gt; Ala or K8 Ser-73 --&gt; Asp with K18 generates normal-appearing filaments.	Aspartic Acid	57-60	keratin 8	Homo sapiens	40-42
11788583-4	2002	Transfection of K8 Ser-73 --&gt; Ala or K8 Ser-73 --&gt; Asp with K18 generates normal-appearing filaments.	Aspartic Acid	57-60	keratin 18	Homo sapiens	66-69
11788583-5	2002	In contrast, exposure to okadaic acid results in keratin filament destabilization in cells expressing wild-type or Ser-73 --&gt; Asp K8, whereas Ser-73 --&gt; Ala K8-expressing cells maintain relatively stable filaments.	Aspartic Acid	129-132	keratin 8	Homo sapiens	133-135
12297037-1	2002	Replacement of the Asp-84 residue of the deoxyguanosine kinase subunit of the tandem deoxyadenosine kinase/ deoxyguanosine kinase (dAK/dGK) from Lactobacillus acidophilus R-26 by Ala, Asn, or Glu produced increased Km values for deoxyguanosine on dGK.	Aspartic Acid	19-22	Diacyl glycerol kinase	Drosophila melanogaster	247-250
12297037-3	2002	The Asp-84 dGK replacements had no apparent effect on the binding of deoxyadenosine by dAK.	Aspartic Acid	4-7	Diacyl glycerol kinase	Drosophila melanogaster	11-14
12297037-6	2002	Therefore, it seems very likely that Asp-84 participates in dGuo binding at the active site of the dGK subunit of dAK/dGK from Lactobacillus acidophilus R-26.	Aspartic Acid	37-40	Diacyl glycerol kinase	Drosophila melanogaster	99-102
12297037-6	2002	Therefore, it seems very likely that Asp-84 participates in dGuo binding at the active site of the dGK subunit of dAK/dGK from Lactobacillus acidophilus R-26.	Aspartic Acid	37-40	Diacyl glycerol kinase	Drosophila melanogaster	118-121
11782471-11	2002	Deletion of Asp-470 (a mutation found in 22% of all PSACH and EDM1 patients) decreased the Ca(2+)-binding capacity of both T3 and T3-Cterm by about 3 mol of Ca(2+)/mol of protein.	Aspartic Acid	12-15	cartilage oligomeric matrix protein	Homo sapiens	62-66
11751902-1	2002	Amino acid Asp-351 in the ligand binding domain of estrogen receptor alpha (ERalpha) plays an important role in regulating the estrogen-like activity of selective estrogen receptor modulator-ERalpha complexes.	Aspartic Acid	11-14	estrogen receptor 1	Homo sapiens	51-74
11790791-2	2002	The caspase-8 inhibitor benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-CH(2)F (IETD) prevented the cleavage of Bid and the loss of viability.	Aspartic Acid	59-62	caspase 8	Homo sapiens	4-13
11790791-2	2002	The caspase-8 inhibitor benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-CH(2)F (IETD) prevented the cleavage of Bid and the loss of viability.	Aspartic Acid	59-62	BH3 interacting domain death agonist	Homo sapiens	108-111
11751902-1	2002	Amino acid Asp-351 in the ligand binding domain of estrogen receptor alpha (ERalpha) plays an important role in regulating the estrogen-like activity of selective estrogen receptor modulator-ERalpha complexes.	Aspartic Acid	11-14	estrogen receptor 1	Homo sapiens	76-83
11751902-1	2002	Amino acid Asp-351 in the ligand binding domain of estrogen receptor alpha (ERalpha) plays an important role in regulating the estrogen-like activity of selective estrogen receptor modulator-ERalpha complexes.	Aspartic Acid	11-14	estrogen receptor 1	Homo sapiens	191-198
11751902-11	2002	These results support the concept that the side chain of raloxifene shields and neutralizes the Asp-351 to produce an antiestrogenic ERalpha complex.	Aspartic Acid	96-99	estrogen receptor 1	Homo sapiens	133-140
12174217-2	2002	By sequencing the coding region of AGM(1), two alleles containing a G or A base at nucleotide 1396, that can respectively encode aspartic acid or asparagine at codon 466, were identified.	Aspartic Acid	129-142	phosphoglucomutase 3	Homo sapiens	35-41
11756418-4	2002	In contrast, the substitution of residues at position Trp-117 and Asp-119 of MTH1, which showed apparent chemical shift perturbations with 8-oxo-dGDP in NMR analyses but are not conserved in MutT, affected the substrate specificity.	Aspartic Acid	66-69	nudix hydrolase 1	Homo sapiens	77-81
11867433-6	2002	The results of these simulations illustrate that the aspartate is capable of attaining a suitable orientation for bidentate coordination, thus implying that it is the inherent rigidity of the loop that prevents bidentate coordination in the parvalbumin E101D mutant.	Aspartic Acid	53-62	parvalbumin	Homo sapiens	241-252
11814862-1	2002	A series of conformationally-restricted analogues of hPTH was prepared, based on the parent peptide agonist, cyclo(Lys(18)-Asp(22))[Ala(1),Nle(8),Lys(18),Asp(22),Leu(27)]hPTH(1-31)NH(2) (2, EC(50)=0.29nM).	Aspartic Acid	123-126	parathyroid hormone	Homo sapiens	53-57
11814862-1	2002	A series of conformationally-restricted analogues of hPTH was prepared, based on the parent peptide agonist, cyclo(Lys(18)-Asp(22))[Ala(1),Nle(8),Lys(18),Asp(22),Leu(27)]hPTH(1-31)NH(2) (2, EC(50)=0.29nM).	Aspartic Acid	154-157	parathyroid hormone	Homo sapiens	53-57
11870079-12	2002	Incubation of OPN-coated microbeads with porcine trophectoderm and uterine luminal epithelial cells induced Arg-Gly-Asp (RGD)-dependent integrin activation and transmembrane accumulation of cytoskeletal molecules at the apical cell surface as assessed by immunofluorescence detection of talin or alpha-actinin as markers for focal adhesions.	Aspartic Acid	116-119	secreted phosphoprotein 1	Sus scrofa	14-17
11854596-7	2002	In addition, a new p53 mutation not previously reported in ET/pPNET involving exon 5 codon 138: GCC to GAC (Ala/Asp) was detected.	Aspartic Acid	112-115	tumor protein p53	Homo sapiens	19-22
11863372-3	2002	We have isolated a protein, NAPP2, which contains an aspartic-acid- and glutamic-acid-rich region and a nuclear localization signal.	Aspartic Acid	53-66	peroxisomal biogenesis factor 14	Homo sapiens	28-33
11875050-7	2002	DNA sequencing of affected individuals from the two American RP10 families revealed a GAC--&gt;AAC transition in codon 226 substituting an asparagine for an aspartic acid in both families.	Aspartic Acid	157-170	inosine monophosphate dehydrogenase 1	Homo sapiens	61-65
11756449-0	2002	Asp-225 and glu-375 in autocatalytic attachment of the prosthetic heme group of lactoperoxidase.	Aspartic Acid	0-3	HEME	Bos taurus	66-70
11854189-4	2002	The predicted 186.8-kDa NanP protein exhibited similarity to a number of bacterial neuraminidases and contained the RIP/RLP motif and five copies of the Asp box motif found in all bacterial neuraminidases.	Aspartic Acid	153-156	N-acetylneuraminic acid phosphatase	Homo sapiens	24-28
11741954-4	2002	In breast carcinoma MCF7 cells deficient in MT1-MMP, pro-alpha(v) is processed by a conventional furin-like PC, and the mature alpha(v) integrin subunit is represented by the 125-kDa heavy chain and the 25-kDa light chain commencing from the N-terminal Asp(891).	Aspartic Acid	253-256	matrix metallopeptidase 14	Homo sapiens	44-51
11741986-7	2002	The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively.	Aspartic Acid	69-72	transmembrane serine protease 2	Homo sapiens	120-127
11724786-13	2002	Finally, the biological properties of mutants together with dynamic docking of SR-146,131 in the CCK1R binding site demonstrated that SR-146,131 occupies a region of CCK1R binding site which interacts with the C-terminal amidated tripeptide of CCK, i.e. Met-Asp-Phe-NH(2).	Aspartic Acid	258-261	cholecystokinin A receptor	Homo sapiens	97-102
11724786-13	2002	Finally, the biological properties of mutants together with dynamic docking of SR-146,131 in the CCK1R binding site demonstrated that SR-146,131 occupies a region of CCK1R binding site which interacts with the C-terminal amidated tripeptide of CCK, i.e. Met-Asp-Phe-NH(2).	Aspartic Acid	258-261	cholecystokinin A receptor	Homo sapiens	166-171
11724786-13	2002	Finally, the biological properties of mutants together with dynamic docking of SR-146,131 in the CCK1R binding site demonstrated that SR-146,131 occupies a region of CCK1R binding site which interacts with the C-terminal amidated tripeptide of CCK, i.e. Met-Asp-Phe-NH(2).	Aspartic Acid	258-261	cholecystokinin	Homo sapiens	97-100
11756449-1	2002	The heme in lactoperoxidase is attached to the protein by ester bonds between the heme 1- and 5-methyl groups and Glu-375 and Asp-275, respectively.	Aspartic Acid	126-129	HEME	Bos taurus	4-8
11741986-7	2002	The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively.	Aspartic Acid	69-72	corin, serine peptidase	Homo sapiens	163-168
12363218-4	2002	Using the X-ray derived conformation of the Ile-Asp-Ser region of VCAM-1, we rationalize the structure-activity relationships of these antagonists using 3D QSAR (COMFA).	Aspartic Acid	48-51	vascular cell adhesion molecule 1	Homo sapiens	66-72
11882671-4	2002	In all cells, the expression of hClC-4 generated strongly outward-rectifying Cl(-) currents with the conductance sequence: SCN(-) &gt;&gt; NO(3)(-) &gt;&gt; Cl(-) &gt; Br(-) approximate I(-) &gt;&gt; aspartate.	Aspartic Acid	200-209	chloride voltage-gated channel 4	Homo sapiens	32-38
11861854-8	2002	During in vitro passage at 37 degrees C, the E176G mutation in rA2-P176 was rapidly changed from glycine to predominantly aspartic acid; mutations to cysteine or serine were also detected.	Aspartic Acid	122-135	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	63-66
11936259-2	2002	So, this fundamental process must be balanced by so far unknown mechanisms, involving caspases (cysteine proteases, cleaving the protein substrate after an aspartate residue).	Aspartic Acid	156-165	caspase 9	Homo sapiens	86-94
11847284-2	2002	Protein isoaspartyl methyltransferase (PIMT) reverts many isoAsp residues to aspartate as a protein repair process.	Aspartic Acid	77-86	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	0-37
11847284-2	2002	Protein isoaspartyl methyltransferase (PIMT) reverts many isoAsp residues to aspartate as a protein repair process.	Aspartic Acid	77-86	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	39-43
11742007-3	2002	Here, we show by site-directed mutagenesis that these residues of human PARN, i.e. Asp(28), Glu(30), Asp(292), and Asp(382), are essential for catalysis but are not required for stabilization of the PARN x RNA substrate complex.	Aspartic Acid	83-86	poly(A)-specific ribonuclease	Homo sapiens	72-76
11742007-3	2002	Here, we show by site-directed mutagenesis that these residues of human PARN, i.e. Asp(28), Glu(30), Asp(292), and Asp(382), are essential for catalysis but are not required for stabilization of the PARN x RNA substrate complex.	Aspartic Acid	83-86	poly(A)-specific ribonuclease	Homo sapiens	199-203
11742007-3	2002	Here, we show by site-directed mutagenesis that these residues of human PARN, i.e. Asp(28), Glu(30), Asp(292), and Asp(382), are essential for catalysis but are not required for stabilization of the PARN x RNA substrate complex.	Aspartic Acid	101-104	poly(A)-specific ribonuclease	Homo sapiens	72-76
11742007-3	2002	Here, we show by site-directed mutagenesis that these residues of human PARN, i.e. Asp(28), Glu(30), Asp(292), and Asp(382), are essential for catalysis but are not required for stabilization of the PARN x RNA substrate complex.	Aspartic Acid	101-104	poly(A)-specific ribonuclease	Homo sapiens	199-203
11742007-3	2002	Here, we show by site-directed mutagenesis that these residues of human PARN, i.e. Asp(28), Glu(30), Asp(292), and Asp(382), are essential for catalysis but are not required for stabilization of the PARN x RNA substrate complex.	Aspartic Acid	101-104	poly(A)-specific ribonuclease	Homo sapiens	72-76
11742007-3	2002	Here, we show by site-directed mutagenesis that these residues of human PARN, i.e. Asp(28), Glu(30), Asp(292), and Asp(382), are essential for catalysis but are not required for stabilization of the PARN x RNA substrate complex.	Aspartic Acid	101-104	poly(A)-specific ribonuclease	Homo sapiens	199-203
11842213-3	2002	When the four human p85alpha proteins were expressed in yeast, a 27% decrease occurred in the level of protein expression of p85alpha(Ile/Asp) (P = 0.03) and a 43% decrease in p85alpha(Ile/Asn) (P = 0.08) as compared with p85alpha(Met/Asp).	Aspartic Acid	138-141	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	20-28
11734558-6	2002	The present data suggest that Pro-2, Asp-6, Pro-8, and Thr-9 are critical for LD78beta binding to CCR5 and HIV-1 replication inhibition, and that LD78beta binding to CCR5, regardless of affinity, is sufficient for the initial signal transduction of LD78beta, whereas the greater anti-HIV-1 activity requires the greater magnitude of binding.	Aspartic Acid	37-40	C-C motif chemokine ligand 3 like 1	Homo sapiens	78-86
11709548-3	2002	Here, we define a Pro-Glu-Asp-Ser-Thr-rich element containing 129 amino acid residues, designated IR1+2, on the human nucleoporin RanBP2/Nup358, which binds directly to Ubc9 with high affinity both in vitro and in vivo.	Aspartic Acid	26-29	RAN binding protein 2	Homo sapiens	130-136
11709548-3	2002	Here, we define a Pro-Glu-Asp-Ser-Thr-rich element containing 129 amino acid residues, designated IR1+2, on the human nucleoporin RanBP2/Nup358, which binds directly to Ubc9 with high affinity both in vitro and in vivo.	Aspartic Acid	26-29	RAN binding protein 2	Homo sapiens	137-143
11842213-3	2002	When the four human p85alpha proteins were expressed in yeast, a 27% decrease occurred in the level of protein expression of p85alpha(Ile/Asp) (P = 0.03) and a 43% decrease in p85alpha(Ile/Asn) (P = 0.08) as compared with p85alpha(Met/Asp).	Aspartic Acid	235-238	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	20-28
11842213-4	2002	Both p85alpha(Ile/Asp) and p85alpha(Ile/Asn) also exhibited increased binding to phospho-insulin receptor substrate-1 by 41% and 83%, respectively (P &lt; 0.001), as compared with p85alpha(Met/Asp).	Aspartic Acid	18-21	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	5-13
11842213-4	2002	Both p85alpha(Ile/Asp) and p85alpha(Ile/Asn) also exhibited increased binding to phospho-insulin receptor substrate-1 by 41% and 83%, respectively (P &lt; 0.001), as compared with p85alpha(Met/Asp).	Aspartic Acid	18-21	insulin receptor substrate 1	Homo sapiens	89-117
11842213-4	2002	Both p85alpha(Ile/Asp) and p85alpha(Ile/Asn) also exhibited increased binding to phospho-insulin receptor substrate-1 by 41% and 83%, respectively (P &lt; 0.001), as compared with p85alpha(Met/Asp).	Aspartic Acid	193-196	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	5-13
11842213-4	2002	Both p85alpha(Ile/Asp) and p85alpha(Ile/Asn) also exhibited increased binding to phospho-insulin receptor substrate-1 by 41% and 83%, respectively (P &lt; 0.001), as compared with p85alpha(Met/Asp).	Aspartic Acid	193-196	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	27-35
11842213-4	2002	Both p85alpha(Ile/Asp) and p85alpha(Ile/Asn) also exhibited increased binding to phospho-insulin receptor substrate-1 by 41% and 83%, respectively (P &lt; 0.001), as compared with p85alpha(Met/Asp).	Aspartic Acid	193-196	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	27-35
11853918-3	2002	The synthesis of branched PEG (40,000) acids has been achieved using aspartic acid (Asp) and AspAsp dendrons.	Aspartic Acid	69-82	progestagen associated endometrial protein	Homo sapiens	26-29
11853918-3	2002	The synthesis of branched PEG (40,000) acids has been achieved using aspartic acid (Asp) and AspAsp dendrons.	Aspartic Acid	84-87	progestagen associated endometrial protein	Homo sapiens	26-29
11734558-6	2002	The present data suggest that Pro-2, Asp-6, Pro-8, and Thr-9 are critical for LD78beta binding to CCR5 and HIV-1 replication inhibition, and that LD78beta binding to CCR5, regardless of affinity, is sufficient for the initial signal transduction of LD78beta, whereas the greater anti-HIV-1 activity requires the greater magnitude of binding.	Aspartic Acid	37-40	C-C motif chemokine receptor 5	Homo sapiens	98-102
11934254-9	2002	IGFBP-1 stimulation of EVT cell migration appears to occur by binding its Arg-Gly-Asp (RGD) domain to alpha5beta1 integrin, leading to phosphorylation of focal adhesion kinase (FAK) and MAPK (ERK-1 and ERK-2).	Aspartic Acid	82-85	insulin like growth factor binding protein 1	Homo sapiens	0-7
11829478-3	2002	Based on the results above, Met(-1) of YaB-G124A was mutated and, as expected, extracellular enzyme production increased with Gln or Ala replacement, but decreased with Ile or Asp substitution.	Aspartic Acid	176-179	granzyme M	Homo sapiens	28-34
11802788-2	2002	Caspase 6 and granzyme B efficiently cleave UFD2 [k(cat)/K(m)=(4-5) x 10(4) M(-1) x s(-1)] at Asp(123), whereas caspases 3 and 7 cleave UFD2 approx.	Aspartic Acid	94-97	caspase 6	Homo sapiens	0-9
11802788-2	2002	Caspase 6 and granzyme B efficiently cleave UFD2 [k(cat)/K(m)=(4-5) x 10(4) M(-1) x s(-1)] at Asp(123), whereas caspases 3 and 7 cleave UFD2 approx.	Aspartic Acid	94-97	granzyme B	Homo sapiens	14-24
11802788-2	2002	Caspase 6 and granzyme B efficiently cleave UFD2 [k(cat)/K(m)=(4-5) x 10(4) M(-1) x s(-1)] at Asp(123), whereas caspases 3 and 7 cleave UFD2 approx.	Aspartic Acid	94-97	ubiquitination factor E4B	Homo sapiens	44-48
11709548-3	2002	Here, we define a Pro-Glu-Asp-Ser-Thr-rich element containing 129 amino acid residues, designated IR1+2, on the human nucleoporin RanBP2/Nup358, which binds directly to Ubc9 with high affinity both in vitro and in vivo.	Aspartic Acid	26-29	ubiquitin conjugating enzyme E2 I	Homo sapiens	169-173
11723135-7	2002	Moreover, the proposal that PrrC residue Asp(287) contacts mnm(5)s(2)U34 was reinforced by the observations that the mammalian tRNA(Lys-3) wobble base 5-methoxycarbonyl methyl-2-thiouridine (mcm(5)s(2)U) is inhibitory and that the D287H mutant favors tRNA(Lys-3) over Escherichia coli tRNA(Lys).	Aspartic Acid	41-44	mitochondrially encoded tRNA glycine	Homo sapiens	127-137
11723135-7	2002	Moreover, the proposal that PrrC residue Asp(287) contacts mnm(5)s(2)U34 was reinforced by the observations that the mammalian tRNA(Lys-3) wobble base 5-methoxycarbonyl methyl-2-thiouridine (mcm(5)s(2)U) is inhibitory and that the D287H mutant favors tRNA(Lys-3) over Escherichia coli tRNA(Lys).	Aspartic Acid	41-44	mitochondrially encoded tRNA glycine	Homo sapiens	251-261
11862419-6	2002	Interestingly, one T-cell line specific for peptide hCG beta 106-121 recognized hCG beta peptides comprising, at position 117, either an alanine or an aspartic acid residue, with the latter residue being present within the protein expressed by some tumor cells.	Aspartic Acid	151-164	chorionic gonadotropin subunit beta 3	Homo sapiens	52-60
11862419-6	2002	Interestingly, one T-cell line specific for peptide hCG beta 106-121 recognized hCG beta peptides comprising, at position 117, either an alanine or an aspartic acid residue, with the latter residue being present within the protein expressed by some tumor cells.	Aspartic Acid	151-164	chorionic gonadotropin subunit beta 3	Homo sapiens	80-88
11897357-0	2002	Histidine pK(a) values for the N-lobe of human transferrin: effect of substitution of binding site Asp by Ser (D63S).	Aspartic Acid	99-102	transferrin	Homo sapiens	47-58
12365458-4	2002	The inhibition of pig heart AST by 50 mM D-fructose or D-ribose was marked even at a temperature of 4 degrees C but it was less pronounced than at 25 degrees C. There was no effect of 0.5 mM 2-oxoglutarate on AST activity during incubation, while the presence of 25 mM L-aspartate decreased it rapidly.	Aspartic Acid	269-280	AST	Sus scrofa	28-31
22896886-1	2002	Wheat germ lipase (WGL) was inactivated by chemical modification of histidine, serine and carboxyl groups of Asp/Glu residues with diethyl pyrocarbonate (DEPC), phenyl methyl sulfonyl fluoride (PMSF) and 1-ethyl-3-(3-dimethylaminopropyl) carbodi-imide (EDC), respectively.	Aspartic Acid	109-112	probable feruloyl esterase A	Triticum aestivum	11-17
11834450-8	2002	We postulate that an arginine-glycine-aspartic acid sequence found on rat and mouse GHBP but absent in other species is responsible for the association of GHBP with the plasma membrane by binding to one or more integrins on the surface of liver cells.	Aspartic Acid	38-51	growth hormone receptor	Mus musculus	84-88
11834450-8	2002	We postulate that an arginine-glycine-aspartic acid sequence found on rat and mouse GHBP but absent in other species is responsible for the association of GHBP with the plasma membrane by binding to one or more integrins on the surface of liver cells.	Aspartic Acid	38-51	growth hormone receptor	Mus musculus	155-159
11753432-3	2002	Here we present the structure of human gelsolin D2 at 1.65 A and find that Asp 187 is part of a Cd2+ metal-binding site.	Aspartic Acid	75-78	gelsolin	Homo sapiens	39-47
11854400-3	2002	The multifunctional Skn7 protein is important in oxidative as well as osmotic stress; however, the Skn7p receiver domain aspartate that is the phosphoacceptor in the SLN1 pathway is dispensable for oxidative stress.	Aspartic Acid	121-130	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	20-24
11812230-5	2002	AK-HSDH exhibited hyperbolic kinetics for aspartate, ATP, homoserine, and NADP with K(M) values of 11.6 mM, 5.5 mM, 5.2 mM, and 166 microM, respectively.	Aspartic Acid	42-51	aspartate kinase-homoserine dehydrogenase ii	Arabidopsis thaliana	0-7
11854400-3	2002	The multifunctional Skn7 protein is important in oxidative as well as osmotic stress; however, the Skn7p receiver domain aspartate that is the phosphoacceptor in the SLN1 pathway is dispensable for oxidative stress.	Aspartic Acid	121-130	histidine kinase	Saccharomyces cerevisiae S288C	166-170
11844113-2	2002	One mutant, mto3, accumulated remarkably high levels of free Met - more than 200-fold that observed for wild type - yet showed little or no difference in the concentrations of other protein amino-acids, such as aspartate, threonine and lysine.	Aspartic Acid	211-220	S-adenosylmethionine synthetase family protein	Arabidopsis thaliana	12-16
11870992-0	2002	ASP joins in MLK March.	Aspartic Acid	0-3	mitogen-activated protein kinase kinase kinase 13	Homo sapiens	13-16
11867224-5	2002	In addition to the N-terminal part, which is similar to the human protein, AtCBP20 has a long C-terminus rich in arginine, glycine and aspartate residues.	Aspartic Acid	135-144	CAP-binding protein 20	Arabidopsis thaliana	75-82
11790133-1	2002	The conserved residues, Arg-349 and Asp-373, of the renal Na(+)/dicarboxylate cotransporter (NaDC-1) have been shown in our previous studies to affect substrate affinity and cation binding.	Aspartic Acid	36-39	solute carrier family 13 member 2	Homo sapiens	93-99
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Aspartic Acid	51-64	dynactin subunit 6	Homo sapiens	144-147
11689574-5	2002	The open r-DGL structure confirms the previous description of the HGL catalytic triad (Ser(153), His(353), and Asp(324)) with the catalytic serine buried and an oxyanion hole (NH groups of Gln(154) and Leu(67)).	Aspartic Acid	111-114	lipase F, gastric type	Homo sapiens	66-69
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Aspartic Acid	51-64	COP9 signalosome subunit 5	Homo sapiens	183-187
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Aspartic Acid	51-64	COP9 signalosome subunit 5	Homo sapiens	116-120
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Aspartic Acid	51-64	COP9 signalosome subunit 5	Homo sapiens	188-192
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Aspartic Acid	51-64	COP9 signalosome subunit 5	Homo sapiens	121-125
11704659-8	2002	Random mutagenesis analysis revealed that specific aspartic acid, leucine, and asparagine residues contained in the Jab1/CSN5-binding domain of p27 were required for interaction with Jab1/CSN5 and for down-regulation of p27.	Aspartic Acid	51-64	dynactin subunit 6	Homo sapiens	220-223
11694528-1	2002	In this report, we show that the echinoderm microtubule (MT)-associated protein (EMAP) and related EMAP-like proteins (ELPs) share a similar domain organization with a highly conserved hydrophobic ELP (HELP) domain and a large tryptophan-aspartic acid (WD) repeat domain.	Aspartic Acid	238-251	EMAP like 1	Homo sapiens	81-85
11785967-6	2002	Since Asp (B10) insulin is also superactive, the observed superactivity may thus stem from either modification of the histidine or its conversion to aspartic acid.	Aspartic Acid	149-162	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	11-14
11785967-6	2002	Since Asp (B10) insulin is also superactive, the observed superactivity may thus stem from either modification of the histidine or its conversion to aspartic acid.	Aspartic Acid	149-162	insulin	Homo sapiens	16-23
11694528-1	2002	In this report, we show that the echinoderm microtubule (MT)-associated protein (EMAP) and related EMAP-like proteins (ELPs) share a similar domain organization with a highly conserved hydrophobic ELP (HELP) domain and a large tryptophan-aspartic acid (WD) repeat domain.	Aspartic Acid	238-251	EMAP like 1	Homo sapiens	99-103
11694528-1	2002	In this report, we show that the echinoderm microtubule (MT)-associated protein (EMAP) and related EMAP-like proteins (ELPs) share a similar domain organization with a highly conserved hydrophobic ELP (HELP) domain and a large tryptophan-aspartic acid (WD) repeat domain.	Aspartic Acid	238-251	nuclear receptor subfamily 5 group A member 1	Homo sapiens	119-122
11694537-6	2002	1) Several mutations centered at adjacent alpha helices 4 and 5 (Gln-335, Tyr-338, Ser-339, Asp-382) caused substantial resistance to DAF and CR1-mediated decay acceleration but not factor H.	Aspartic Acid	92-95	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	142-145
11843288-5	2002	Polymerase chain reaction revealed that the abnormal Hb was caused by a missense mutation within codon 83 of the beta-globin gene (GGC to GAC) resulting in a glycine-to-aspartic acid substitution, which corresponds to Hb Pyrgos.	Aspartic Acid	169-182	gamma-glutamylcyclotransferase	Homo sapiens	131-134
11866094-5	2002	In the absence of urea, an aspartic acid residue at the P1" site was unfavorable for OmpT cleavage of synthetic decapeptides, the enzyme showed a preference for a dibasic site.	Aspartic Acid	27-40	outer membrane protease	Escherichia coli	85-89
11754473-5	2002	We develop a different approach to the problem of ASP analysis in the presence of covariates, one that extends naturally to ARP under certain conditions.	Aspartic Acid	50-53	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	124-127
11747988-3	2002	One fragment showed 94% identity to bovine PDE5 and coded for the high affinity cGB domain of PDE5 (Val(156)-Asp(394), cGB-I).	Aspartic Acid	109-112	phosphodiesterase 5A	Homo sapiens	43-47
11747988-3	2002	One fragment showed 94% identity to bovine PDE5 and coded for the high affinity cGB domain of PDE5 (Val(156)-Asp(394), cGB-I).	Aspartic Acid	109-112	chromogranin B	Bos taurus	80-83
11747988-3	2002	One fragment showed 94% identity to bovine PDE5 and coded for the high affinity cGB domain of PDE5 (Val(156)-Asp(394), cGB-I).	Aspartic Acid	109-112	phosphodiesterase 5A	Homo sapiens	94-98
11747988-3	2002	One fragment showed 94% identity to bovine PDE5 and coded for the high affinity cGB domain of PDE5 (Val(156)-Asp(394), cGB-I).	Aspartic Acid	109-112	chromogranin B	Bos taurus	119-122
11784313-3	2002	Subsequent mutational analysis demonstrated an absolute requirement for two conserved Asp residues (Asp321 and Asp323), which are located in the most homologous region of rat GnT-III, for enzymatic activity.	Aspartic Acid	86-89	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	175-182
12111653-8	2002	The Asn822(Lys) mutation affects a highly conserved codon within the tyrosine kinase activation loop leading, likewise the Asp(816) mutants, to constitutive ligand-independent activation of the KIT receptor.	Aspartic Acid	123-126	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	194-197
11900275-7	2002	RESULTS: A significant enrichment in DQB1 alleles encoding for an amino acid different from Asp in position 57 (NA) and DQA1 alleles encoding for Arg in position 52 was observed in diabetic subjects and first-degree relatives as compared to controls.	Aspartic Acid	92-95	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	37-41
12392527-8	2002	The main enzyme cleavage sites were Lys-Trp, Val-Lys, Gly-Asp and Asp-Arg, as determined after incubation of P1 and P2 with the beta-chain of insulin.	Aspartic Acid	58-61	crystallin gamma F, pseudogene	Homo sapiens	109-118
16233295-1	2002	We have increased the contents of several amino acids in the seeds of Arabidopsis thaliana by introduction of aspartate aminotransferase (AAT), an enzyme of the aspartate biosynthetic pathway.	Aspartic Acid	110-119	aspartate aminotransferase	Arabidopsis thaliana	138-141
12430566-1	2002	The human nuclear protein RbAp48 is a member of the tryptophan/aspartate (WD) repeat family, which binds to the retinoblastoma (Rb) protein.	Aspartic Acid	63-72	RB binding protein 4, chromatin remodeling factor	Homo sapiens	26-32
11826020-7	2002	The child was heterozygous for a COL1A1 4321G--&gt;T transversion in exon 52 that changed a conserved aspartic acid to tyrosine (D1441Y).	Aspartic Acid	102-115	collagen type I alpha 1 chain	Homo sapiens	33-39
12111366-7	2002	Since the function of citrin, together with that of an isoform, aralar, was found to be as a mitochondrial aspartate glutamate carrier, the various symptoms of NICCD and CTLN2 may be understood as caused by defective aspartate export from the mitochondria to the cytosol and defects in the malate aspartate shuttle.	Aspartic Acid	107-116	solute carrier family 25 member 13	Homo sapiens	22-28
12111366-7	2002	Since the function of citrin, together with that of an isoform, aralar, was found to be as a mitochondrial aspartate glutamate carrier, the various symptoms of NICCD and CTLN2 may be understood as caused by defective aspartate export from the mitochondria to the cytosol and defects in the malate aspartate shuttle.	Aspartic Acid	217-226	solute carrier family 25 member 13	Homo sapiens	22-28
12111366-7	2002	Since the function of citrin, together with that of an isoform, aralar, was found to be as a mitochondrial aspartate glutamate carrier, the various symptoms of NICCD and CTLN2 may be understood as caused by defective aspartate export from the mitochondria to the cytosol and defects in the malate aspartate shuttle.	Aspartic Acid	217-226	solute carrier family 25 member 13	Homo sapiens	22-28
12494183-4	2002	In patients without left ventricular hypertrophy (LVH) genotypes frequencies of NOS3 (Glu298Asp) were: Glu/Glu - 34.4%; Glu/Asp - 62,5%; Asp/Asp - 3,1%.	Aspartic Acid	92-95	nitric oxide synthase 3	Homo sapiens	80-84
12494183-4	2002	In patients without left ventricular hypertrophy (LVH) genotypes frequencies of NOS3 (Glu298Asp) were: Glu/Glu - 34.4%; Glu/Asp - 62,5%; Asp/Asp - 3,1%.	Aspartic Acid	124-127	nitric oxide synthase 3	Homo sapiens	80-84
12494183-4	2002	In patients without left ventricular hypertrophy (LVH) genotypes frequencies of NOS3 (Glu298Asp) were: Glu/Glu - 34.4%; Glu/Asp - 62,5%; Asp/Asp - 3,1%.	Aspartic Acid	124-127	nitric oxide synthase 3	Homo sapiens	80-84
11779637-2	2001	A novel missense mutation, Asp (AAT) to Ser (AGT), was identified at amino acid position 439 of the hypocatalasemic catalase.	Aspartic Acid	27-30	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	32-35
12044451-7	2002	The PAPA/NO-elicited release of glutamate and aspartate was diminished by superfusion with the inhibitor of guanylyl cyclase, NS 2028.	Aspartic Acid	46-55	pappalysin 1	Homo sapiens	4-8
11779637-2	2001	A novel missense mutation, Asp (AAT) to Ser (AGT), was identified at amino acid position 439 of the hypocatalasemic catalase.	Aspartic Acid	27-30	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	45-48
11604391-7	2001	ACE also significantly inhibited A beta cytotoxicity on PC12 h. The most striking fact was that ACE degraded A beta by cleaving A beta-(1-40) at the site Asp(7)-Ser(8).	Aspartic Acid	154-157	angiotensin I converting enzyme	Homo sapiens	0-3
11604391-7	2001	ACE also significantly inhibited A beta cytotoxicity on PC12 h. The most striking fact was that ACE degraded A beta by cleaving A beta-(1-40) at the site Asp(7)-Ser(8).	Aspartic Acid	154-157	angiotensin I converting enzyme	Homo sapiens	96-99
11604391-7	2001	ACE also significantly inhibited A beta cytotoxicity on PC12 h. The most striking fact was that ACE degraded A beta by cleaving A beta-(1-40) at the site Asp(7)-Ser(8).	Aspartic Acid	154-157	amyloid beta precursor protein	Homo sapiens	109-115
11742072-3	2001	The derepression of Mak activity was associated with a single base change at position 71 (codon 24) of the gene, where GCC (alanine) in Mak-o has been changed to GAC (aspartate) in Mak(+).	Aspartic Acid	167-176	male germ cell associated kinase	Homo sapiens	20-23
11604391-7	2001	ACE also significantly inhibited A beta cytotoxicity on PC12 h. The most striking fact was that ACE degraded A beta by cleaving A beta-(1-40) at the site Asp(7)-Ser(8).	Aspartic Acid	154-157	amyloid beta precursor protein	Homo sapiens	109-115
11735425-8	2001	The different mechanisms of binding to RAP domains 1 and 3 are further substantiated by the different effects on binding of mutations of the Asp and Trp residues in the LRP CR5 or CR6 domains, which are important for the recognition of several ligands.	Aspartic Acid	141-144	LDL receptor related protein associated protein 1	Homo sapiens	39-42
11735425-8	2001	The different mechanisms of binding to RAP domains 1 and 3 are further substantiated by the different effects on binding of mutations of the Asp and Trp residues in the LRP CR5 or CR6 domains, which are important for the recognition of several ligands.	Aspartic Acid	141-144	LDL receptor related protein 1	Homo sapiens	169-172
11742072-3	2001	The derepression of Mak activity was associated with a single base change at position 71 (codon 24) of the gene, where GCC (alanine) in Mak-o has been changed to GAC (aspartate) in Mak(+).	Aspartic Acid	167-176	male germ cell associated kinase	Homo sapiens	136-139
11742072-3	2001	The derepression of Mak activity was associated with a single base change at position 71 (codon 24) of the gene, where GCC (alanine) in Mak-o has been changed to GAC (aspartate) in Mak(+).	Aspartic Acid	167-176	male germ cell associated kinase	Homo sapiens	136-139
11741585-0	2001	Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp.	Aspartic Acid	110-113	laminin, alpha 5	Mus musculus	14-28
11598120-2	2001	In the insulin receptor"s kinase domain, Asp-1161 and Tyr-1162 in the peptide substrate-like sequence of the unphosphorylated activation loop can interact with four invariant residues in the active site: Lys-1085, Asp-1132, Arg-1136, and Gln-1208.	Aspartic Acid	41-44	insulin receptor	Homo sapiens	7-23
11598120-2	2001	In the insulin receptor"s kinase domain, Asp-1161 and Tyr-1162 in the peptide substrate-like sequence of the unphosphorylated activation loop can interact with four invariant residues in the active site: Lys-1085, Asp-1132, Arg-1136, and Gln-1208.	Aspartic Acid	214-217	insulin receptor	Homo sapiens	7-23
11579085-7	2001	Conversely, mutation to aspartic acid reduces the binding of the protein to CaM and abrogates almost completely the death-promoting function of the protein.	Aspartic Acid	24-37	calmodulin 1	Homo sapiens	76-79
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Aspartic Acid	169-172	Rac family small GTPase 1	Homo sapiens	24-28
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Aspartic Acid	169-172	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Aspartic Acid	169-172	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Aspartic Acid	169-172	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Aspartic Acid	298-301	Rac family small GTPase 1	Homo sapiens	24-28
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Aspartic Acid	298-301	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Aspartic Acid	298-301	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Aspartic Acid	298-301	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
14655281-0	2001	[Role of aspartic acid at position 57 of the HLA-DQ beta chain in sporadic and familial forms of selective IgA deficiency].	Aspartic Acid	9-22	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	45-56
14655281-2	2001	A protective effect of an aspartic acid residue at position 57 of the DQ beta chain against IgAD has been repeatedly described.	Aspartic Acid	26-39	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	70-77
11723228-6	2001	Molecular modeling suggested that the nonconserved Asp-271 in transmembrane domain 7 of gpH2R (Ala-271 in hH2R) confers high potency to guanidines.	Aspartic Acid	51-54	histamine receptor H2	Homo sapiens	106-110
14655281-3	2001	The aim of our study was to determine, whether the genetic effect of non-aspartic acids (non-Asp) at position 57 of the DQ beta chain is different in familial and non-familial forms of IgAD.	Aspartic Acid	73-87	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	120-127
14655281-3	2001	The aim of our study was to determine, whether the genetic effect of non-aspartic acids (non-Asp) at position 57 of the DQ beta chain is different in familial and non-familial forms of IgAD.	Aspartic Acid	93-96	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	120-127
14655281-7	2001	CONCLUSION: The protective effect of non-aspartic acid at position 57 of the DQ beta chain is present in both sporadic and familial form of IgAD.	Aspartic Acid	41-54	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	77-84
11831390-5	2001	The products of D28N and D28G clones were localized in the cytoplasm, showing that the aspartic acid-28 may be essential for the delivery of SGLT1 to the plasma membrane.	Aspartic Acid	87-100	solute carrier family 5 member 1	Canis lupus familiaris	141-146
11723228-7	2001	This hypothesis was confirmed by Ala-271--&gt;Asp-271 mutation in hH2R-GsalphaS.	Aspartic Acid	46-49	histamine receptor H2	Homo sapiens	66-70
11726783-1	2001	Aspartate synthesis in GABAergic neurons was estimated following inhibition of glutamate decarboxylase (GAD) with 3-mercaptopropionic acid (3-MPA).	Aspartic Acid	0-9	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	79-102
11726783-1	2001	Aspartate synthesis in GABAergic neurons was estimated following inhibition of glutamate decarboxylase (GAD) with 3-mercaptopropionic acid (3-MPA).	Aspartic Acid	0-9	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	104-107
11723235-2	2001	The Glu(7.32(301)) residue, which determines selectivity of the mouse GnRH receptor for Arg(8)-containing GnRH, is Asp(7.32(302)) in the human GnRH receptor.	Aspartic Acid	115-118	gonadotropin releasing hormone receptor	Mus musculus	70-83
11723235-2	2001	The Glu(7.32(301)) residue, which determines selectivity of the mouse GnRH receptor for Arg(8)-containing GnRH, is Asp(7.32(302)) in the human GnRH receptor.	Aspartic Acid	115-118	gonadotropin releasing hormone 1	Homo sapiens	70-74
11723235-2	2001	The Glu(7.32(301)) residue, which determines selectivity of the mouse GnRH receptor for Arg(8)-containing GnRH, is Asp(7.32(302)) in the human GnRH receptor.	Aspartic Acid	115-118	gonadotropin releasing hormone receptor	Homo sapiens	143-156
11723235-3	2001	We have confirmed that Asp(7.32(302)) confers selectivity of the human GnRH receptor for Arg(8) of GnRH and investigated the mechanism of this specificity using site-directed mutagenesis and ligand modification.	Aspartic Acid	23-26	gonadotropin releasing hormone receptor	Homo sapiens	71-84
11723235-3	2001	We have confirmed that Asp(7.32(302)) confers selectivity of the human GnRH receptor for Arg(8) of GnRH and investigated the mechanism of this specificity using site-directed mutagenesis and ligand modification.	Aspartic Acid	23-26	gonadotropin releasing hormone 1	Homo sapiens	71-75
11723235-4	2001	We find that although Arg(8) and Asp(7.32(302)) are required for high-affinity binding of GnRH, conformationally constrained peptides, with D-amino acid substitutions in position six or with a 6,7 gamma-lactam, bind the human GnRH receptor with high affinity, which is independent of the presence of Asp(7.32(302)) in the receptor or Arg(8) in the ligand.	Aspartic Acid	33-36	gonadotropin releasing hormone 1	Homo sapiens	90-94
11723235-4	2001	We find that although Arg(8) and Asp(7.32(302)) are required for high-affinity binding of GnRH, conformationally constrained peptides, with D-amino acid substitutions in position six or with a 6,7 gamma-lactam, bind the human GnRH receptor with high affinity, which is independent of the presence of Asp(7.32(302)) in the receptor or Arg(8) in the ligand.	Aspartic Acid	33-36	gonadotropin releasing hormone receptor	Homo sapiens	226-239
11723235-4	2001	We find that although Arg(8) and Asp(7.32(302)) are required for high-affinity binding of GnRH, conformationally constrained peptides, with D-amino acid substitutions in position six or with a 6,7 gamma-lactam, bind the human GnRH receptor with high affinity, which is independent of the presence of Asp(7.32(302)) in the receptor or Arg(8) in the ligand.	Aspartic Acid	300-303	gonadotropin releasing hormone 1	Homo sapiens	90-94
11723235-6	2001	This suggests that the Arg(8) and Asp(7.32(302)) side chains interact to induce a high affinity conformation of native GnRH.	Aspartic Acid	34-37	gonadotropin releasing hormone 1	Homo sapiens	119-123
11723235-7	2001	Thus, Asp(7.32(302)) of the human GnRH receptor determines selectivity for mammalian GnRH by its ability to induce a high affinity conformation of its native ligand.	Aspartic Acid	6-9	gonadotropin releasing hormone receptor	Homo sapiens	34-47
11723235-7	2001	Thus, Asp(7.32(302)) of the human GnRH receptor determines selectivity for mammalian GnRH by its ability to induce a high affinity conformation of its native ligand.	Aspartic Acid	6-9	gonadotropin releasing hormone 1	Homo sapiens	34-38
11716984-4	2001	In this study, we demonstrate that overexpression of human beta-secretase (BACE-1) in HEK293 cells resulted in predominant Abeta cleavage at position Glu(11) rather than Asp(1), as well as increased production of Abeta(x)-34, but not Abeta(x)-40.	Aspartic Acid	170-173	beta-secretase 1	Homo sapiens	75-81
11723235-9	2001	We propose that Arg(8) interacts transiently with Asp(7.32(302)) to induce a high-affinity ligand conformation of GnRH, which then interacts with a binding pocket that is common for both constrained and unconstrained analogs of GnRH.	Aspartic Acid	50-53	gonadotropin releasing hormone 1	Homo sapiens	114-118
11723235-9	2001	We propose that Arg(8) interacts transiently with Asp(7.32(302)) to induce a high-affinity ligand conformation of GnRH, which then interacts with a binding pocket that is common for both constrained and unconstrained analogs of GnRH.	Aspartic Acid	50-53	gonadotropin releasing hormone 1	Homo sapiens	228-232
11559698-7	2001	The participation of Glu(350), Asp(355), and Arg(356) provides a molecular explanation for the differential exposure of this epitope in the different conformations of PAI-1 and for the effect of these antibodies on the kinetics of the formation of the initial PAI-1-proteinase complexes.	Aspartic Acid	31-34	serpin family E member 1	Homo sapiens	167-172
11698641-4	2001	Conversion of serine 388 to glycine abolishes UBF activity, whereas substitution by aspartate enhances the transactivating function of UBF.	Aspartic Acid	84-93	upstream binding transcription factor	Homo sapiens	135-138
11723295-1	2001	The authors describe a novel missense mutation in the presenilin 2 (PSEN2) gene at residue 439 that predicts an aspartate-to-alanine substitution (D439A).	Aspartic Acid	112-121	presenilin 2	Homo sapiens	54-66
11723295-1	2001	The authors describe a novel missense mutation in the presenilin 2 (PSEN2) gene at residue 439 that predicts an aspartate-to-alanine substitution (D439A).	Aspartic Acid	112-121	presenilin 2	Homo sapiens	68-73
11551913-5	2001	Here, we report that PS1/PS2 null and dominant negative PS1 mutants, which are mutated at aspartate residue 257 or 385, did not affect signaling of the UPR.	Aspartic Acid	90-99	presenilin 1	Homo sapiens	21-24
11551913-5	2001	Here, we report that PS1/PS2 null and dominant negative PS1 mutants, which are mutated at aspartate residue 257 or 385, did not affect signaling of the UPR.	Aspartic Acid	90-99	presenilin 1	Homo sapiens	56-59
11698587-5	2001	In addition, we tested the hypothesis that the conserved aspartate (D2.50) in the second transmembrane domain of the CB1 cannabinoid receptor is crucial for constitutive activity and G-protein sequestration.	Aspartic Acid	57-66	cannabinoid receptor 1	Homo sapiens	117-120
11564743-0	2001	Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.	Aspartic Acid	20-29	amyloid beta (A4) precursor protein	Mus musculus	87-112
11564743-1	2001	PS1 deficiency and expression of PS1 with substitutions of two conserved transmembrane aspartate residues ("PS1 aspartate variants") leads to the reduction of Abeta peptide secretion and the accumulation of amyloid precursor protein (APP) C-terminal fragments.	Aspartic Acid	87-96	presenilin 1	Mus musculus	0-3
11564743-1	2001	PS1 deficiency and expression of PS1 with substitutions of two conserved transmembrane aspartate residues ("PS1 aspartate variants") leads to the reduction of Abeta peptide secretion and the accumulation of amyloid precursor protein (APP) C-terminal fragments.	Aspartic Acid	87-96	presenilin 1	Mus musculus	33-36
11564743-1	2001	PS1 deficiency and expression of PS1 with substitutions of two conserved transmembrane aspartate residues ("PS1 aspartate variants") leads to the reduction of Abeta peptide secretion and the accumulation of amyloid precursor protein (APP) C-terminal fragments.	Aspartic Acid	87-96	amyloid beta (A4) precursor protein	Mus musculus	207-232
11564743-1	2001	PS1 deficiency and expression of PS1 with substitutions of two conserved transmembrane aspartate residues ("PS1 aspartate variants") leads to the reduction of Abeta peptide secretion and the accumulation of amyloid precursor protein (APP) C-terminal fragments.	Aspartic Acid	112-121	presenilin 1	Mus musculus	0-3
11564743-1	2001	PS1 deficiency and expression of PS1 with substitutions of two conserved transmembrane aspartate residues ("PS1 aspartate variants") leads to the reduction of Abeta peptide secretion and the accumulation of amyloid precursor protein (APP) C-terminal fragments.	Aspartic Acid	112-121	presenilin 1	Mus musculus	33-36
11564743-1	2001	PS1 deficiency and expression of PS1 with substitutions of two conserved transmembrane aspartate residues ("PS1 aspartate variants") leads to the reduction of Abeta peptide secretion and the accumulation of amyloid precursor protein (APP) C-terminal fragments.	Aspartic Acid	112-121	amyloid beta (A4) precursor protein	Mus musculus	207-232
11564743-2	2001	To define the nature of the "dominant negative" effect of the PS1 aspartate variants, we stably expressed PS1 harboring aspartate to alanine substitutions at codons 257 (D257A) or 385 (D385A), singly or in combination (D257A/D385A), in mouse neuroblastoma, N2a cells.	Aspartic Acid	66-75	presenilin 1	Mus musculus	62-65
11564743-3	2001	Expression of the PS1 aspartate variants resulted in marked accumulation of intracellular and cell surface APP C-terminal fragments.	Aspartic Acid	22-31	presenilin 1	Mus musculus	18-21
11564743-6	2001	These findings lead us to conclude that the stability and trafficking of APP can be profoundly modulated by coexpression of PS1 with mutations at aspartate 257 and aspartate 385.	Aspartic Acid	146-155	presenilin 1	Mus musculus	124-127
11698587-6	2001	We found that the mutation of aspartate to asparagine (CB1-D164N) abolished G-protein sequestration and constitutive receptor activity without disrupting agonist-stimulated activity.	Aspartic Acid	30-39	cannabinoid receptor 1	Homo sapiens	55-58
11593035-7	2001	Independent overexpression of the PS1 NTF and CTF was also used to show that the Asp-257 and Asp-385 mutations in PS1 decrease Abeta production by a direct effect on gamma-secretase activity and not by the inhibition of PS1 endoproteolysis.	Aspartic Acid	81-84	presenilin 1	Homo sapiens	34-37
11555640-6	2001	Using site-directed mutagenesis we show that PKR is specifically proteolysed at Asp(251) during cellular apoptosis.	Aspartic Acid	80-83	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	45-48
11509570-6	2001	These mutants indicate that the interaction interface involves conserved Mog1p residues Asp(62) and Glu(65), and residue Lys(136) in yeast Ran.	Aspartic Acid	88-91	Ran GTPase-binding protein MOG1	Saccharomyces cerevisiae S288C	73-78
11675361-6	2001	Sequencing analysis identified a G-to-T transition within the CBFA2 gene, which involves codon 198, encoding a conserved aspartic acid within the DNA- binding Runt domain.	Aspartic Acid	121-134	RUNX family transcription factor 1	Homo sapiens	62-67
11741536-4	2001	We report here that IkappaB kinase (IKK) beta was specifically proteolyzed by Caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (TNF)-alpha-induced apoptosis.	Aspartic Acid	108-121	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	20-45
11741536-4	2001	We report here that IkappaB kinase (IKK) beta was specifically proteolyzed by Caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (TNF)-alpha-induced apoptosis.	Aspartic Acid	108-121	caspase 3	Homo sapiens	78-87
11741536-4	2001	We report here that IkappaB kinase (IKK) beta was specifically proteolyzed by Caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (TNF)-alpha-induced apoptosis.	Aspartic Acid	108-121	tumor necrosis factor	Homo sapiens	160-193
11601995-4	2001	Seven site-specific point mutants of MDP-1 were produced by modifying the catalytic aspartate, serine, and lysine residues to asparagine or glutamate, alanine, and arginine, respectively.	Aspartic Acid	84-93	magnesium dependent phosphatase 1	Homo sapiens	37-42
29712138-2	2001	It is important for the inhibition of cell adhesion that the arabino sialyl Lewisx glycopeptide 1, which contains the Gly 672 -Asp 681 sequence of the E-selectin Ligand 1 (ESL-1), binds ten times more strongly than sialyl Lewisx to E-selectin, although it is monovalent and does not contain L-fucose, which is considered essential.	Aspartic Acid	127-130	golgi glycoprotein 1	Homo sapiens	151-170
29712138-2	2001	It is important for the inhibition of cell adhesion that the arabino sialyl Lewisx glycopeptide 1, which contains the Gly 672 -Asp 681 sequence of the E-selectin Ligand 1 (ESL-1), binds ten times more strongly than sialyl Lewisx to E-selectin, although it is monovalent and does not contain L-fucose, which is considered essential.	Aspartic Acid	127-130	golgi glycoprotein 1	Homo sapiens	172-177
29712138-2	2001	It is important for the inhibition of cell adhesion that the arabino sialyl Lewisx glycopeptide 1, which contains the Gly 672 -Asp 681 sequence of the E-selectin Ligand 1 (ESL-1), binds ten times more strongly than sialyl Lewisx to E-selectin, although it is monovalent and does not contain L-fucose, which is considered essential.	Aspartic Acid	127-130	selectin E	Homo sapiens	151-161
11731079-5	2001	Western blotting using MMP-9-specific antibodies prepared against the peptide corresponding to Arg(642)-Asp(704) of canine MMP-9 and Northern blotting using a MMP-9-specific cDNA fragment as a probe confirmed that MMP-9 (the 92 kDa protein band) was highly expressed in canine mammary adenocarcinoma tissues.	Aspartic Acid	104-107	matrix metallopeptidase 9	Canis lupus familiaris	123-128
11731079-5	2001	Western blotting using MMP-9-specific antibodies prepared against the peptide corresponding to Arg(642)-Asp(704) of canine MMP-9 and Northern blotting using a MMP-9-specific cDNA fragment as a probe confirmed that MMP-9 (the 92 kDa protein band) was highly expressed in canine mammary adenocarcinoma tissues.	Aspartic Acid	104-107	matrix metallopeptidase 9	Canis lupus familiaris	123-128
11731079-5	2001	Western blotting using MMP-9-specific antibodies prepared against the peptide corresponding to Arg(642)-Asp(704) of canine MMP-9 and Northern blotting using a MMP-9-specific cDNA fragment as a probe confirmed that MMP-9 (the 92 kDa protein band) was highly expressed in canine mammary adenocarcinoma tissues.	Aspartic Acid	104-107	matrix metallopeptidase 9	Canis lupus familiaris	123-128
11779085-2	2001	Integrin alpha(v)beta3 interacts with RGD (Arg-Gly-Asp) sequence-containing proteins in the extracellular matrix.	Aspartic Acid	51-54	integrin subunit alpha V	Homo sapiens	0-22
11910529-10	2001	At an equimolar concentration (10 microM), L-AP3 but not ifenprodil, MCPG, MK 801 or arcaine, caused a significant (p &lt; 0.001) inhibition of hypoxia-induced [(3)H]D-aspartate release from human retinae.	Aspartic Acid	168-177	leucine aminopeptidase 3	Homo sapiens	43-48
11711497-6	2001	DNA samples were screened for 4 NOS 3 gene polymorphisms: -786 T/C, -922 A/G, 894 G/T (which predicts a Glu(298)--&gt;Asp amino acid substitution in the mature protein), and a 27-bp tandem repeat in intron 4 (eNOS4a/4b).	Aspartic Acid	118-121	nitric oxide synthase 3	Homo sapiens	32-37
11602718-4	2001	The critical determinant for this effect was an acidic amino acid at position 13 in the CCR5 N terminus, which is an asparagine in huCCR5 and an aspartic acid in rhCCR5.	Aspartic Acid	145-158	C-C motif chemokine receptor 5	Homo sapiens	88-92
11691584-3	2001	We have identified a novel missense mutation which substitutes a glycine for an aspartic acid residue in the thrombospondin (TSP) type 3 calcium-binding domain of COMP in a patient diagnosed with PSACH.	Aspartic Acid	80-93	thrombospondin 1	Homo sapiens	109-123
11691584-3	2001	We have identified a novel missense mutation which substitutes a glycine for an aspartic acid residue in the thrombospondin (TSP) type 3 calcium-binding domain of COMP in a patient diagnosed with PSACH.	Aspartic Acid	80-93	thrombospondin 1	Homo sapiens	125-128
11691584-3	2001	We have identified a novel missense mutation which substitutes a glycine for an aspartic acid residue in the thrombospondin (TSP) type 3 calcium-binding domain of COMP in a patient diagnosed with PSACH.	Aspartic Acid	80-93	cartilage oligomeric matrix protein	Homo sapiens	163-167
11641422-9	2001	Finally, Asp-146, which is also remote from the binding site, was shown to be involved in the differential binding affinity of [(3)H]LY354740 for mGlu2 versus mGlu3 receptors.	Aspartic Acid	9-12	glutamate receptor, metabotropic 3	Mus musculus	159-164
11687971-4	2001	Substitution of the aspartic acid residue 231 by an asparagine residue in its catalytic site abrogated the cathepsin-D proteolytic activity but did not affect its expression level, processing or secretion.	Aspartic Acid	20-33	cathepsin D	Mus musculus	107-118
11593035-7	2001	Independent overexpression of the PS1 NTF and CTF was also used to show that the Asp-257 and Asp-385 mutations in PS1 decrease Abeta production by a direct effect on gamma-secretase activity and not by the inhibition of PS1 endoproteolysis.	Aspartic Acid	81-84	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	46-49
11580253-10	2001	Consistent with this idea, Abeta peptides containing Asp-->Asn or His-->Gln substitutions showed altered fibrillogenesis kinetics.	Aspartic Acid	53-56	amyloid beta precursor protein	Homo sapiens	27-32
11593035-7	2001	Independent overexpression of the PS1 NTF and CTF was also used to show that the Asp-257 and Asp-385 mutations in PS1 decrease Abeta production by a direct effect on gamma-secretase activity and not by the inhibition of PS1 endoproteolysis.	Aspartic Acid	81-84	presenilin 1	Homo sapiens	114-117
11593035-7	2001	Independent overexpression of the PS1 NTF and CTF was also used to show that the Asp-257 and Asp-385 mutations in PS1 decrease Abeta production by a direct effect on gamma-secretase activity and not by the inhibition of PS1 endoproteolysis.	Aspartic Acid	81-84	presenilin 1	Homo sapiens	114-117
11593035-7	2001	Independent overexpression of the PS1 NTF and CTF was also used to show that the Asp-257 and Asp-385 mutations in PS1 decrease Abeta production by a direct effect on gamma-secretase activity and not by the inhibition of PS1 endoproteolysis.	Aspartic Acid	93-96	presenilin 1	Homo sapiens	34-37
11593035-7	2001	Independent overexpression of the PS1 NTF and CTF was also used to show that the Asp-257 and Asp-385 mutations in PS1 decrease Abeta production by a direct effect on gamma-secretase activity and not by the inhibition of PS1 endoproteolysis.	Aspartic Acid	93-96	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	46-49
11593035-7	2001	Independent overexpression of the PS1 NTF and CTF was also used to show that the Asp-257 and Asp-385 mutations in PS1 decrease Abeta production by a direct effect on gamma-secretase activity and not by the inhibition of PS1 endoproteolysis.	Aspartic Acid	93-96	presenilin 1	Homo sapiens	114-117
11593035-7	2001	Independent overexpression of the PS1 NTF and CTF was also used to show that the Asp-257 and Asp-385 mutations in PS1 decrease Abeta production by a direct effect on gamma-secretase activity and not by the inhibition of PS1 endoproteolysis.	Aspartic Acid	93-96	presenilin 1	Homo sapiens	114-117
11557499-3	2001	TLE-1 differed from TEM-1 by a single Asp(115)--&gt;Gly substitution and has been renamed TEM-90.	Aspartic Acid	38-41	TLE family member 1, transcriptional corepressor	Homo sapiens	0-5
11603727-9	2001	Blocking of the beta1-integrin with cyclic-peptides containing the Arg-Gly-Asp sequences and antibodies reduced chondrocyte attachment to Type II collagen by 93%.	Aspartic Acid	75-78	integrin subunit beta 1	Homo sapiens	16-30
11557236-2	2001	In this study we have tested the hypothesis that the high affinity sodium-dependent aspartate transporter, EAAC-1 is expressed in heart and have also characterised aspartate transport into the myocardium.	Aspartic Acid	84-93	solute carrier family 1 member 1	Rattus norvegicus	107-113
11557457-5	2001	Speculating that the multiple acidic residues of human LL-37 reduced its efficacy against staphylococci, we made a peptide (LL-37 pentamide) in which each aspartic acid of LL-37 was replaced by an asparagine and each glutamic acid was replaced by a glutamine.	Aspartic Acid	155-168	cathelicidin antimicrobial peptide	Homo sapiens	55-60
11557457-5	2001	Speculating that the multiple acidic residues of human LL-37 reduced its efficacy against staphylococci, we made a peptide (LL-37 pentamide) in which each aspartic acid of LL-37 was replaced by an asparagine and each glutamic acid was replaced by a glutamine.	Aspartic Acid	155-168	cathelicidin antimicrobial peptide	Homo sapiens	124-129
11557457-5	2001	Speculating that the multiple acidic residues of human LL-37 reduced its efficacy against staphylococci, we made a peptide (LL-37 pentamide) in which each aspartic acid of LL-37 was replaced by an asparagine and each glutamic acid was replaced by a glutamine.	Aspartic Acid	155-168	cathelicidin antimicrobial peptide	Homo sapiens	124-129
11589694-10	2001	Recently, the structure of human cytosolic PLA(2) (cPLA(2)) was solved, showing a novel Ser-Asp active site dyad [1].	Aspartic Acid	92-95	phospholipase A2 group IVA	Homo sapiens	33-49
11589694-10	2001	Recently, the structure of human cytosolic PLA(2) (cPLA(2)) was solved, showing a novel Ser-Asp active site dyad [1].	Aspartic Acid	92-95	phospholipase A2 group IVA	Homo sapiens	51-58
11723742-4	2001	The cell-binding domain obtained from fibronectin included the Arg-Gly-Asp (RGD) sequence.	Aspartic Acid	71-74	fibronectin 1	Mus musculus	38-49
11563836-0	2001	Glu(191) and Asp(195) in rat mitochondrial processing peptidase beta subunit are involved in effective cleavage of precursor protein through interaction with the proximal arginine.	Aspartic Acid	13-16	peptidase, mitochondrial processing subunit beta	Rattus norvegicus	29-76
11568176-1	2001	We hypothesized that administration of an antisense oligodeoxynucleotide (ODN) to estrogen receptor (ER)-alpha mRNA decreases the ER protein in the neonatal rat brain, alters the sex-specific ventilatory responses to aspartic acid in rats, and counteracts the effects of testosterone proportionate (TP) in females.	Aspartic Acid	217-230	estrogen receptor 1	Rattus norvegicus	82-110
11568176-1	2001	We hypothesized that administration of an antisense oligodeoxynucleotide (ODN) to estrogen receptor (ER)-alpha mRNA decreases the ER protein in the neonatal rat brain, alters the sex-specific ventilatory responses to aspartic acid in rats, and counteracts the effects of testosterone proportionate (TP) in females.	Aspartic Acid	217-230	estrogen receptor 1	Rattus norvegicus	101-103
11568288-0	2001	A novel inhibitor of beta-glucuronidase: L-aspartic acid.	Aspartic Acid	41-56	glucuronidase beta	Homo sapiens	21-39
11568288-6	2001	The L-aspartic acid in hydrolyzed casein accounts for the majority of the beta-glucuronidase inhibition present.	Aspartic Acid	4-19	glucuronidase beta	Homo sapiens	74-92
11739897-0	2001	Mutating aspartate in the calcium-binding site of alpha-lactalbumin: effects on the protein stability and cation binding.	Aspartic Acid	9-18	lactalbumin alpha	Bos taurus	50-67
11568288-8	2001	L-aspartic acid is a newly identified competitive inhibitor of beta-glucuronidase.	Aspartic Acid	0-15	glucuronidase beta	Homo sapiens	63-81
11833424-2	2001	Microinjection of ANG II (100 pmol, n = 11) into the RVLM significantly increased (P &lt; 0.01) the release of aspartate (from 4.75 +/- 1.01 to 8.90 +/- 2.28 pmol/20 microliters) and glutamate (from 18.99 +/- 8.64 to 73.88 +/- 29.26 pmol/20 microliters) in the spinal cord.	Aspartic Acid	111-120	angiotensinogen	Homo sapiens	18-24
11477073-3	2001	Our current study indicates that 4 amino acid residues in hFEN-1 (Leu-340, Asp-341, Phe-343, and Phe-344) are critical for human PCNA (hPCNA) interaction.	Aspartic Acid	75-78	flap structure-specific endonuclease 1	Homo sapiens	58-64
11477073-3	2001	Our current study indicates that 4 amino acid residues in hFEN-1 (Leu-340, Asp-341, Phe-343, and Phe-344) are critical for human PCNA (hPCNA) interaction.	Aspartic Acid	75-78	proliferating cell nuclear antigen	Homo sapiens	129-133
11461921-4	2001	A calcium-dependent-binding site was localized to the central (Asp(1028)-Thr(1486)) region of fibrillin-1.	Aspartic Acid	63-66	fibrillin 1	Homo sapiens	94-105
11438526-5	2001	The Cys(177) as well as Asp(175) and Glu(176) were identified as critical residues for ABP1 folding and action at the plasma membrane.	Aspartic Acid	24-27	amine oxidase copper containing 1	Homo sapiens	87-91
11565034-3	2001	Here we show that turnover of phosphorylated cyclin E depends on an SCF-type protein-ubiquitin ligase that contains the human homologue of yeast Cdc4, which is an F-box protein containing repeated sequences of WD40 (a unit containing about 40 residues with tryptophan (W) and aspartic acid (D) at defined positions).	Aspartic Acid	276-289	SCF ubiquitin ligase complex subunit CDC4	Saccharomyces cerevisiae S288C	145-149
11556807-4	2001	The coding sequence for two highly conserved aspartate residues, D46 and D47, in the QCR7 gene was altered by site-directed mutagenesis and the mutated genes expressed in cells lacking a functional QCR7 gene.	Aspartic Acid	45-54	ubiquinol--cytochrome-c reductase subunit 7	Saccharomyces cerevisiae S288C	85-89
11559199-2	2001	All four possible stereoisomers of the inhibitor were synthesized in an enantiomerically pure form starting with optically active aspartic acid, and their CPA inhibitory activities were evaluated to find that surprisingly all of the four stereoisomers inhibit CPA in a time dependent manner.	Aspartic Acid	130-143	carboxypeptidase A1	Homo sapiens	260-263
11566871-5	2001	These results demonstrate that citrin and aralar1 are isoforms of the hitherto unidentified aspartate/glutamate carrier and explain why mutations in citrin cause type II citrullinemia in humans.	Aspartic Acid	92-101	solute carrier family 25 member 13	Homo sapiens	31-37
11566871-5	2001	These results demonstrate that citrin and aralar1 are isoforms of the hitherto unidentified aspartate/glutamate carrier and explain why mutations in citrin cause type II citrullinemia in humans.	Aspartic Acid	92-101	solute carrier family 25 member 13	Homo sapiens	149-155
11435437-5	2001	The protein-modification bond is of a new type in which an aspartic acid in LTP1 is bound to the modification through what most likely is an ester bond.	Aspartic Acid	59-72	non-specific lipid transport protein 1	Hordeum vulgare	76-80
11387340-4	2001	We identify the two major sites at which SRF cleavage occurs as Asp(245) and Asp(254), the caspases responsible for the cleavage and generate a mutant of SRF resistant to cleavage in BJAB cells.	Aspartic Acid	64-67	serum response factor	Homo sapiens	41-44
11387340-4	2001	We identify the two major sites at which SRF cleavage occurs as Asp(245) and Asp(254), the caspases responsible for the cleavage and generate a mutant of SRF resistant to cleavage in BJAB cells.	Aspartic Acid	64-67	serum response factor	Homo sapiens	154-157
11387340-4	2001	We identify the two major sites at which SRF cleavage occurs as Asp(245) and Asp(254), the caspases responsible for the cleavage and generate a mutant of SRF resistant to cleavage in BJAB cells.	Aspartic Acid	77-80	serum response factor	Homo sapiens	41-44
11402024-4	2001	Site-directed mutagenesis of Asp-1125 in ErbB-2 prevents geldanamycin-provoked formation of the 23-kDa fragment, consistent with the requirement of this residue for caspase-dependent cleavage in known substrates.	Aspartic Acid	29-32	erb-b2 receptor tyrosine kinase 2	Homo sapiens	41-47
11545602-12	2001	If the protonation state of a histidine, aspartate or glutamate protein side-chain is known, specific CSD-based maps for that protonation state are preferred over PDB-based maps which represent an ensemble of protonation states.	Aspartic Acid	41-50	cysteine sulfinic acid decarboxylase	Homo sapiens	102-105
11557066-2	2001	Substituting serine 48 in human SRA1 by an aspartate demonstrated that (1) surface expression of the mutated receptor was 13-fold decreased; (2) the amount of cell-associated Texas red-labeled acetylated low density lipoprotein (LDL) in mutant receptor-expressing cells was almost three-fold reduced; (3) the migration of mutant receptor-transfected cells towards surfaces coated with oxidized LDL decreased by almost 60% compared to cells that were transfected with the wild type receptor.	Aspartic Acid	43-52	steroid receptor RNA activator 1	Homo sapiens	32-36
11676033-5	2001	Together with the results from an in vitro phosphorelay assay with AHP2 and ARRs, these results are discussed, in terms of a geneal framework of the Arabidopsis His-to-Asp phosphorelay network.	Aspartic Acid	168-171	histidine-containing phosphotransmitter 2	Arabidopsis thaliana	67-71
11532685-10	2001	After correction of all P values for multiple comparisons, the ND3 A10086G (Asn--&gt;Asp) mutation shown by TaqI remained statistically significant (P = 0.0036) in the H-ESRD cohort, not in the normotensive cohort.	Aspartic Acid	85-88	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	63-66
11514347-6	2001	Functional analysis of potential OPN interactions with conceptus and endometrial integrins was performed on LE and Tr cells in vitro using beads coated with OPN, poly-L-lysine, or recombinant OPN in which the Arg-Gly-Asp sequence was replaced with RGE or RAD.	Aspartic Acid	217-220	osteopontin	Ovis aries	33-36
11898552-5	2001	Two intramembranous aspartate residues in presenilin (PS) are absolutely required for A beta generation.	Aspartic Acid	20-29	amyloid beta precursor protein	Homo sapiens	86-92
11507189-7	2001	Replacement of both serine residues 151 and 153 with phosphomimetic aspartic acid restored Rex-2 function and locked Rex-2 in a phosphorylated active conformation.	Aspartic Acid	68-81	RNA exonuclease 2	Homo sapiens	91-96
11561725-4	2001	The sequences around the proposed active site Asp, His, and Ser residues of KpcA are similar to those of other Kex2p family members.	Aspartic Acid	46-49	kexin KEX2	Saccharomyces cerevisiae S288C	111-116
11484220-4	2001	In the predicted structure of the complexes, the pyrophosphate interacts with the DVD motif (Asp-225, Val-226, and Asp-227) of alpha-1,3-GalT through the Mn(2+) cation.	Aspartic Acid	93-96	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	127-141
11484220-4	2001	In the predicted structure of the complexes, the pyrophosphate interacts with the DVD motif (Asp-225, Val-226, and Asp-227) of alpha-1,3-GalT through the Mn(2+) cation.	Aspartic Acid	115-118	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	127-141
11583320-0	2001	Factor IX Denver, ASN 346--&gt;ASP mutation resulting in a dysfunctional protein with defective factor VIIIa interaction.	Aspartic Acid	31-34	coagulation factor IX	Homo sapiens	0-9
11507211-6	2001	Mutation of Val to Asp in the ORF74 second cytoplasmic loop did not affect ligand-independent signaling activity, but it greatly increased the response to GROalpha.	Aspartic Acid	19-22	ORF74	Human gammaherpesvirus 8	30-35
11683253-1	2001	PURPOSE: The purpose of this paper is to determine the significance of cyclic imide formation of an aspartic acid residue during storage on the pharmaceutical quality of a recombinant human glial cell line-derived neurotrophic factor (rhGDNF) formulation.	Aspartic Acid	100-113	glial cell derived neurotrophic factor	Homo sapiens	190-233
11402050-2	2001	Upon caspase cleavage at Asp-87, the 10- and 25-kDa cleavage products of P35 remain tightly associated with the inhibited caspase.	Aspartic Acid	25-28	caspase 8	Homo sapiens	5-12
11402050-2	2001	Upon caspase cleavage at Asp-87, the 10- and 25-kDa cleavage products of P35 remain tightly associated with the inhibited caspase.	Aspartic Acid	25-28	interleukin 12A	Homo sapiens	73-76
11402050-2	2001	Upon caspase cleavage at Asp-87, the 10- and 25-kDa cleavage products of P35 remain tightly associated with the inhibited caspase.	Aspartic Acid	25-28	caspase 8	Homo sapiens	122-129
11517317-0	2001	Characterization of key residues in the subdomain encoded by exons 8 and 9 of human inducible nitric oxide synthase: a critical role for Asp-280 in substrate binding and subunit interactions.	Aspartic Acid	137-140	nitric oxide synthase 2	Homo sapiens	84-115
11513603-2	2001	HMGB1 consists of 2 DNA binding domains, the HMG boxes A and B, followed by a short basic region and a continuous stretch of 30 glutamate or aspartate residues.	Aspartic Acid	141-150	high mobility group box 1	Homo sapiens	0-5
11517317-11	2001	These data, by defining a critical role for Asp-280 in substrate binding and subunit interactions, give insights into the mechanisms of regulation of iNOS activity.	Aspartic Acid	44-47	nitric oxide synthase 2	Homo sapiens	150-154
11472212-2	2001	Using a previously developed spatial screening technique we describe the development of potent and selective alpha(4)beta(7) integrin antagonists based on the domain 1 Leu-Asp-Thr (LDT) sequence of MAdCAM-1 that is essential for alpha(4)beta(7) integrin binding.	Aspartic Acid	172-175	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	198-206
11408486-8	2001	However, replacing Gln3p Ser-344, Ser-347, and Ser-355 with aspartates results in significant loss of its ability to be concentrated in the nucleus.	Aspartic Acid	60-70	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	19-24
11390392-8	2001	Moreover, substitution of Asn-26 in IL-2 with Gln or Asp conserved the dimeric form and affected the carbohydrate recognition activities in correspondence with the cell proliferation activities, suggesting that Asn-26 in IL-2 is involved in the carbohydrate recognition site.	Aspartic Acid	53-56	interleukin 2	Homo sapiens	221-225
11478852-1	2001	Two residues have been shown to be critical for the kinase activity of the receptor for epidermal growth factor (EGF): lysine-721, which functions in the binding of ATP by correctly positioning the gamma-phosphate for phosphoryl transfer, and aspartate-813, which functions as the catalytic base of the kinase.	Aspartic Acid	243-252	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	88-111
11478852-1	2001	Two residues have been shown to be critical for the kinase activity of the receptor for epidermal growth factor (EGF): lysine-721, which functions in the binding of ATP by correctly positioning the gamma-phosphate for phosphoryl transfer, and aspartate-813, which functions as the catalytic base of the kinase.	Aspartic Acid	243-252	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	113-116
11478852-4	2001	In the present study, EGF receptors mutated at lysine-721 or aspartate-813 (K721R and D813A, respectively), as well as wild-type EGF receptors, were expressed in the same cellular background, Chinese hamster ovary cells, and side-by-side experiments were performed to investigate possible signaling-related differences.	Aspartic Acid	61-70	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	22-25
11527579-3	2001	Allosteric inhibitors like L-malate and L-aspartate predominantly decrease the affinity of the carboxylase for PEP at pH 7.0.	Aspartic Acid	40-51	phosphoenolpyruvate carboxylase 2	Zea mays	111-114
11502364-4	2001	Recently, an A-->G polymorphism has been reported in exon 4 of the cathepsin G gene, which changes the codon AAC ((125) Asp) to AGC ((125)Ser).	Aspartic Acid	120-123	cathepsin G	Homo sapiens	67-78
11406636-5	2001	An essential catalytic aspartate in TdT was identified, which is a first step toward understanding the apparent lack of sugar discrimination by TdT.	Aspartic Acid	23-32	DNA nucleotidylexotransferase	Homo sapiens	36-39
11406636-5	2001	An essential catalytic aspartate in TdT was identified, which is a first step toward understanding the apparent lack of sugar discrimination by TdT.	Aspartic Acid	23-32	DNA nucleotidylexotransferase	Homo sapiens	144-147
11526478-7	2001	Single mutation of Asp 19 or Asp 18 in the unique N-terminal domains of Fyn and Lyn respectively abolished their cleavage and relocation into the cytoplasm of apoptotic cells.	Aspartic Acid	19-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
11526478-7	2001	Single mutation of Asp 19 or Asp 18 in the unique N-terminal domains of Fyn and Lyn respectively abolished their cleavage and relocation into the cytoplasm of apoptotic cells.	Aspartic Acid	19-22	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
11526478-7	2001	Single mutation of Asp 19 or Asp 18 in the unique N-terminal domains of Fyn and Lyn respectively abolished their cleavage and relocation into the cytoplasm of apoptotic cells.	Aspartic Acid	29-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
11526478-7	2001	Single mutation of Asp 19 or Asp 18 in the unique N-terminal domains of Fyn and Lyn respectively abolished their cleavage and relocation into the cytoplasm of apoptotic cells.	Aspartic Acid	29-32	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
11683413-10	2001	Ala substitutions for the Trp and Asp residues in the conserved WDT motif in the beta1 tail had dramatic effects on the ability of tac-beta1 to regulate integrin conformation and function in cell spreading, but had no or intermediate effects in other assays.	Aspartic Acid	34-37	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	81-86
11479221-6	2001	Helenalin led to a time-dependent (0-24 h) cleavage of the specific caspase-3-like substrate Asp-Glu-Val-Asp-7-amino-4-trifluoromethylcoumarin as well as to the proteolytic processing of procaspase-3 and -8.	Aspartic Acid	93-96	caspase 3	Homo sapiens	187-206
11531804-5	2001	We report a new amino acid substitution mutation in codon 155 of KRT1 (valine to aspartic acid) in the conserved H1 domain of the protein in the patient with BCIE.	Aspartic Acid	81-94	keratin 1	Homo sapiens	65-69
11502818-7	2001	The P450scc mutation, an in-frame insertion of Gly and Asp between Asp271 and Val272, was inserted into a catalytically active fusion protein of the P450scc system (H2N-P450scc-Adrenodoxin Reductase-Adrenodoxin-COOH), completely inactivating enzymatic activity.	Aspartic Acid	55-58	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	4-11
11502818-7	2001	The P450scc mutation, an in-frame insertion of Gly and Asp between Asp271 and Val272, was inserted into a catalytically active fusion protein of the P450scc system (H2N-P450scc-Adrenodoxin Reductase-Adrenodoxin-COOH), completely inactivating enzymatic activity.	Aspartic Acid	55-58	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	149-156
11502818-7	2001	The P450scc mutation, an in-frame insertion of Gly and Asp between Asp271 and Val272, was inserted into a catalytically active fusion protein of the P450scc system (H2N-P450scc-Adrenodoxin Reductase-Adrenodoxin-COOH), completely inactivating enzymatic activity.	Aspartic Acid	55-58	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	149-156
11683413-9	2001	Ala substitutions for the Val residue in the VTT motif of the beta1 tail or for the conserved Asp and Glu residues in the membrane-proximal region of the beta3 tail greatly diminished the ability of tac-beta1 and tac-beta3 to inhibit cell spreading, but had minimal effects in other assays.	Aspartic Acid	94-97	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	154-159
11683413-9	2001	Ala substitutions for the Val residue in the VTT motif of the beta1 tail or for the conserved Asp and Glu residues in the membrane-proximal region of the beta3 tail greatly diminished the ability of tac-beta1 and tac-beta3 to inhibit cell spreading, but had minimal effects in other assays.	Aspartic Acid	94-97	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	203-208
11683413-10	2001	Ala substitutions for the Trp and Asp residues in the conserved WDT motif in the beta1 tail had dramatic effects on the ability of tac-beta1 to regulate integrin conformation and function in cell spreading, but had no or intermediate effects in other assays.	Aspartic Acid	34-37	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	135-140
11683413-9	2001	Ala substitutions for the Val residue in the VTT motif of the beta1 tail or for the conserved Asp and Glu residues in the membrane-proximal region of the beta3 tail greatly diminished the ability of tac-beta1 and tac-beta3 to inhibit cell spreading, but had minimal effects in other assays.	Aspartic Acid	94-97	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	217-222
11438643-8	2001	All three caspases cleaved AP-2alpha at asp(19) of the sequence asp-arg-his-asp (DRHD(19)).	Aspartic Acid	11-14	transcription factor AP-2 alpha	Homo sapiens	27-36
11466416-1	2001	A dominant form of human congenital nightblindness is caused by a gly90--&gt;asp (G90D) mutation in rhodopsin.	Aspartic Acid	77-80	rhodopsin	Homo sapiens	100-109
11438643-8	2001	All three caspases cleaved AP-2alpha at asp(19) of the sequence asp-arg-his-asp (DRHD(19)).	Aspartic Acid	40-43	caspase 1	Homo sapiens	10-18
11438643-8	2001	All three caspases cleaved AP-2alpha at asp(19) of the sequence asp-arg-his-asp (DRHD(19)).	Aspartic Acid	40-43	transcription factor AP-2 alpha	Homo sapiens	27-36
11532179-4	2001	The N-terminus of p44 contains a degradation motif characterized by proline, glutamate, aspartate, serine and threonine residues (PEST), which can be inactivated by mutation of three glutamic acid residues to alanines.	Aspartic Acid	88-97	interferon induced protein 44	Homo sapiens	18-21
11494148-7	2001	These results demonstrate that activation of STAT3 by Asp(816) mutant c-Kit is required for the anchorage-independent growth and tumorigenicity induced by Asp(816) mutant c-Kit.	Aspartic Acid	54-57	signal transducer and activator of transcription 3	Homo sapiens	45-50
11444980-7	2001	The active site general-base implicated by these kinetic results is believed to be His-334, of the highly conserved TGase Cys-His-Asp catalytic triad.	Aspartic Acid	130-133	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	116-121
11494148-0	2001	STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity.	Aspartic Acid	33-36	signal transducer and activator of transcription 3	Homo sapiens	0-5
11494148-0	2001	STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity.	Aspartic Acid	33-36	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	49-54
11494148-7	2001	These results demonstrate that activation of STAT3 by Asp(816) mutant c-Kit is required for the anchorage-independent growth and tumorigenicity induced by Asp(816) mutant c-Kit.	Aspartic Acid	54-57	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-75
11494148-1	2001	Activating mutations of c-kit at codon 816 (Asp(816)) have been identified in variety of malignancies, including acute myeloid leukemia (AML), mastocytosis and germ cell tumors.	Aspartic Acid	44-47	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	24-29
11342557-4	2001	By using the triple aspartate mutant, a mimic of phosphorylated HSP27, as "bait" construct, a protein with a molecular mass of 21.6 kDa was identified as an HSP27-binding protein.	Aspartic Acid	20-29	heat shock protein family B (small) member 1	Homo sapiens	64-69
11494148-7	2001	These results demonstrate that activation of STAT3 by Asp(816) mutant c-Kit is required for the anchorage-independent growth and tumorigenicity induced by Asp(816) mutant c-Kit.	Aspartic Acid	54-57	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	171-176
11342557-4	2001	By using the triple aspartate mutant, a mimic of phosphorylated HSP27, as "bait" construct, a protein with a molecular mass of 21.6 kDa was identified as an HSP27-binding protein.	Aspartic Acid	20-29	heat shock protein family B (small) member 1	Homo sapiens	157-162
11494148-7	2001	These results demonstrate that activation of STAT3 by Asp(816) mutant c-Kit is required for the anchorage-independent growth and tumorigenicity induced by Asp(816) mutant c-Kit.	Aspartic Acid	155-158	signal transducer and activator of transcription 3	Homo sapiens	45-50
11342557-8	2001	According to the two-hybrid data, HSP22 interacts preferentially with the triple aspartate form of HSP27 as compared with wild-type HSP27.	Aspartic Acid	81-90	heat shock protein family B (small) member 8	Homo sapiens	34-39
11342557-8	2001	According to the two-hybrid data, HSP22 interacts preferentially with the triple aspartate form of HSP27 as compared with wild-type HSP27.	Aspartic Acid	81-90	heat shock protein family B (small) member 1	Homo sapiens	99-104
11494148-7	2001	These results demonstrate that activation of STAT3 by Asp(816) mutant c-Kit is required for the anchorage-independent growth and tumorigenicity induced by Asp(816) mutant c-Kit.	Aspartic Acid	155-158	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-75
11494148-7	2001	These results demonstrate that activation of STAT3 by Asp(816) mutant c-Kit is required for the anchorage-independent growth and tumorigenicity induced by Asp(816) mutant c-Kit.	Aspartic Acid	155-158	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	171-176
11415453-4	2001	Mutation of the active-site residues Asp(88) or His(118) within the human PP2A catalytic subunit (PP2Ac)alpha impaired catalytic activity in vitro; the D88N and H118N substitutions caused a 9- and 23-fold reduction in specific activity respectively, when compared with wild-type recombinant PP2Ac, indicating an important role for these residues in catalysis.	Aspartic Acid	37-40	protein phosphatase 2 phosphatase activator	Homo sapiens	74-78
11331296-0	2001	Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)--&gt;Asp variant of human endothelial nitric-oxide synthase.	Aspartic Acid	71-74	nitric oxide synthase 3	Homo sapiens	92-125
11331296-1	2001	The 894G--&gt;T polymorphism within exon 7 of the human endothelial nitric-oxide synthase (eNOS) gene codes for glutamate or aspartate, respectively, at residue 298 and has been associated with several diseases of cardiovascular origin.	Aspartic Acid	125-134	nitric oxide synthase 3	Homo sapiens	56-89
11331296-1	2001	The 894G--&gt;T polymorphism within exon 7 of the human endothelial nitric-oxide synthase (eNOS) gene codes for glutamate or aspartate, respectively, at residue 298 and has been associated with several diseases of cardiovascular origin.	Aspartic Acid	125-134	nitric oxide synthase 3	Homo sapiens	91-95
11331296-2	2001	A recent report indicates that Asp(298)-eNOS (E298D) is cleaved intracellularly to 100- and 35-kDa fragments, suggesting a mechanism for reduced endothelial function.	Aspartic Acid	31-34	nitric oxide synthase 3	Homo sapiens	40-44
11415439-3	2001	We demonstrate here that CaBP1, similar to PDI and CaBP2, can complement the lethal phenotype of the disrupted Saccharomyces cerevisiae PDI gene, provided that the natural C-terminal Lys-Asp-Glu-Leu sequence is replaced by His-Asp-Glu-Leu.	Aspartic Acid	187-190	calcium binding protein 1	Rattus norvegicus	25-30
11415439-3	2001	We demonstrate here that CaBP1, similar to PDI and CaBP2, can complement the lethal phenotype of the disrupted Saccharomyces cerevisiae PDI gene, provided that the natural C-terminal Lys-Asp-Glu-Leu sequence is replaced by His-Asp-Glu-Leu.	Aspartic Acid	227-230	calcium binding protein 1	Rattus norvegicus	25-30
11356849-2	2001	Two known K18 caspase cleavage sites are aspartates in the consensus sequences VEVDA and DALDS, located within the rod domain and tail domain, respectively.	Aspartic Acid	41-51	keratin 18	Homo sapiens	10-13
11352900-4	2001	In this study we demonstrate that Zn(2+) ions inhibit the uncoupled anion conductance and also reduce the affinity of L-aspartate for EAAT4.	Aspartic Acid	118-129	solute carrier family 1 member 6	Homo sapiens	134-139
11352902-9	2001	These results suggest that Arg(49) and Asp(50) may be targeted for the design of potent and selective inhibitors of TCPTP and PTP1B.	Aspartic Acid	39-42	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	116-121
11352902-9	2001	These results suggest that Arg(49) and Asp(50) may be targeted for the design of potent and selective inhibitors of TCPTP and PTP1B.	Aspartic Acid	39-42	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	126-131
11320092-4	2001	Data presented in this study establish that p65/RelA, a subunit of NF-kappaB, is cleaved at Asp(97) by caspase-3 during apoptosis.	Aspartic Acid	92-95	RELA proto-oncogene, NF-kB subunit	Homo sapiens	44-47
11320092-4	2001	Data presented in this study establish that p65/RelA, a subunit of NF-kappaB, is cleaved at Asp(97) by caspase-3 during apoptosis.	Aspartic Acid	92-95	RELA proto-oncogene, NF-kB subunit	Homo sapiens	48-52
11320092-4	2001	Data presented in this study establish that p65/RelA, a subunit of NF-kappaB, is cleaved at Asp(97) by caspase-3 during apoptosis.	Aspartic Acid	92-95	nuclear factor kappa B subunit 1	Homo sapiens	67-76
11320092-4	2001	Data presented in this study establish that p65/RelA, a subunit of NF-kappaB, is cleaved at Asp(97) by caspase-3 during apoptosis.	Aspartic Acid	92-95	caspase 3	Homo sapiens	103-112
11408214-0	2001	Interaction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87).	Aspartic Acid	113-116	DNA topoisomerase II alpha	Homo sapiens	20-30
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	36-49	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	128-131
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	36-49	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	136-139
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	36-49	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	149-152
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	36-49	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	149-152
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	36-49	LDL receptor related protein associated protein 1	Homo sapiens	279-306
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	36-49	LDL receptor related protein associated protein 1	Homo sapiens	308-311
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	36-49	LDL receptor related protein 1	Homo sapiens	378-381
11415453-4	2001	Mutation of the active-site residues Asp(88) or His(118) within the human PP2A catalytic subunit (PP2Ac)alpha impaired catalytic activity in vitro; the D88N and H118N substitutions caused a 9- and 23-fold reduction in specific activity respectively, when compared with wild-type recombinant PP2Ac, indicating an important role for these residues in catalysis.	Aspartic Acid	37-40	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	98-103
11418466-2	2001	The molecular basis for the observed phenotype is a substitution of glycine for aspartate in the strictly conserved codon 218 (D218G) of the amino-terminal zinc finger loop of the transcription factor GATA1.	Aspartic Acid	80-89	GATA binding protein 1	Homo sapiens	201-206
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	141-144	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	128-131
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	141-144	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	136-139
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	155-158	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	163-166
11415462-6	2001	We demonstrate that surface-exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains, CR5 and CR6 (Asp(958,CR5), Asp(999,CR6), Trp(953,CR5) and Trp(994,CR6)), are critical for the binding of the complex as well as for the binding of the receptor-associated protein (RAP) - the folding chaperone/escort protein required for transport of LRP to the cell surface.	Aspartic Acid	155-158	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	163-166
11418470-11	2001	RGDS (Arg-Gly-Asp-Ser) or antibodies to alpha5beta1 or alphaIIbbeta3 integrins caused a partial decrease in LPA-induced deposition of FITC-FN.	Aspartic Acid	14-17	ral guanine nucleotide dissociation stimulator	Homo sapiens	0-4
11418470-11	2001	RGDS (Arg-Gly-Asp-Ser) or antibodies to alpha5beta1 or alphaIIbbeta3 integrins caused a partial decrease in LPA-induced deposition of FITC-FN.	Aspartic Acid	14-17	fibronectin 1	Homo sapiens	134-141
11418481-5	2001	Database comparisons with EAF1 identified a region with a high content of serine, aspartic acid, and glutamic acid residues that exhibited homology with the transcriptional activation domains of several translocation partner proteins of MLL, including AF4, LAF4, and AF5q31.	Aspartic Acid	82-95	ELL associated factor 1	Mus musculus	26-30
11418481-5	2001	Database comparisons with EAF1 identified a region with a high content of serine, aspartic acid, and glutamic acid residues that exhibited homology with the transcriptional activation domains of several translocation partner proteins of MLL, including AF4, LAF4, and AF5q31.	Aspartic Acid	82-95	lysine (K)-specific methyltransferase 2A	Mus musculus	237-240
11418481-5	2001	Database comparisons with EAF1 identified a region with a high content of serine, aspartic acid, and glutamic acid residues that exhibited homology with the transcriptional activation domains of several translocation partner proteins of MLL, including AF4, LAF4, and AF5q31.	Aspartic Acid	82-95	AF4/FMR2 family, member 3	Mus musculus	257-261
11418481-5	2001	Database comparisons with EAF1 identified a region with a high content of serine, aspartic acid, and glutamic acid residues that exhibited homology with the transcriptional activation domains of several translocation partner proteins of MLL, including AF4, LAF4, and AF5q31.	Aspartic Acid	82-95	AF4/FMR2 family, member 4	Mus musculus	267-273
11426296-0	2001	Characterization of Na+-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1.	Aspartic Acid	42-51	solute carrier family 1 member 3	Rattus norvegicus	103-108
11426296-0	2001	Characterization of Na+-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1.	Aspartic Acid	42-51	solute carrier family 1 member 1	Rattus norvegicus	113-118
11432999-11	2001	The EAAT4-mediated currents for the two substrates, L-glutamate and L-aspartate, were not enhanced equally by addition of the same dose of niflumic acid and the ionic composition of the niflumic acid-induced currents was not the same for the two substrates.	Aspartic Acid	68-79	solute carrier family 1 member 6	Homo sapiens	4-9
11408611-8	2001	Thus, the negatively charged aspartate residues at positions 171 and 262, located in transmembrane domains 4 and 6 of the 7-transmembrane receptor, respectively, may represent crucial sites for electrostatic interaction of the positive charges of the bicyclams, as well as for the highly basic V3 loop of the gp120 envelope protein of certain HIV-1 strains.	Aspartic Acid	29-38	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	309-314
11408611-0	2001	Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.	Aspartic Acid	12-15	C-X-C motif chemokine receptor 4	Homo sapiens	60-65
11408611-0	2001	Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.	Aspartic Acid	25-28	C-X-C motif chemokine receptor 4	Homo sapiens	60-65
11408611-4	2001	We found that the antagonistic action of AMD3100 against CXCR4--as assessed by the inhibitory effects of the compound on stromal cell-derived factor (SDF-1) binding to its receptor and on SDF-1-induced intracellular calcium signaling, and by displacement of the CXCR4-specific antibody, clone 12G5--was greatly reduced by substitution of Asp(171) and/or Asp(262) by neutral asparagine residue(s).	Aspartic Acid	338-341	C-X-C motif chemokine receptor 4	Homo sapiens	57-62
11408611-4	2001	We found that the antagonistic action of AMD3100 against CXCR4--as assessed by the inhibitory effects of the compound on stromal cell-derived factor (SDF-1) binding to its receptor and on SDF-1-induced intracellular calcium signaling, and by displacement of the CXCR4-specific antibody, clone 12G5--was greatly reduced by substitution of Asp(171) and/or Asp(262) by neutral asparagine residue(s).	Aspartic Acid	354-357	C-X-C motif chemokine receptor 4	Homo sapiens	57-62
11437602-4	2001	Amino-terminal sequence analysis of the caspase 3 polypeptides proved that caspase 8 had specifically cleaved the Asp(175)-Ser(176) bond to yield the expected p18 and p12 subunits, with partial cleavage at the Asp(28)-Ser(29) bond to release the prosegment.	Aspartic Acid	114-117	caspase 3	Homo sapiens	40-49
11437602-4	2001	Amino-terminal sequence analysis of the caspase 3 polypeptides proved that caspase 8 had specifically cleaved the Asp(175)-Ser(176) bond to yield the expected p18 and p12 subunits, with partial cleavage at the Asp(28)-Ser(29) bond to release the prosegment.	Aspartic Acid	114-117	caspase 8	Homo sapiens	75-84
11437602-4	2001	Amino-terminal sequence analysis of the caspase 3 polypeptides proved that caspase 8 had specifically cleaved the Asp(175)-Ser(176) bond to yield the expected p18 and p12 subunits, with partial cleavage at the Asp(28)-Ser(29) bond to release the prosegment.	Aspartic Acid	114-117	H3 histone pseudogene 12	Homo sapiens	159-162
11437602-4	2001	Amino-terminal sequence analysis of the caspase 3 polypeptides proved that caspase 8 had specifically cleaved the Asp(175)-Ser(176) bond to yield the expected p18 and p12 subunits, with partial cleavage at the Asp(28)-Ser(29) bond to release the prosegment.	Aspartic Acid	114-117	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	167-170
11437602-4	2001	Amino-terminal sequence analysis of the caspase 3 polypeptides proved that caspase 8 had specifically cleaved the Asp(175)-Ser(176) bond to yield the expected p18 and p12 subunits, with partial cleavage at the Asp(28)-Ser(29) bond to release the prosegment.	Aspartic Acid	210-213	caspase 8	Homo sapiens	75-84
11312274-2	2001	Here, we identified a molecular interaction between Asp(633) in transmembrane helix 6 (TM6) and Asn(674) in TM7 of the TSHr that is crucial to maintain the inactive state through conformational constraint of the Asn.	Aspartic Acid	52-55	thyroid stimulating hormone receptor	Homo sapiens	119-123
11274162-6	2001	Protein AVT6 is responsible for the efflux of aspartate and glutamate, an activity that would account for their exclusion from vacuoles in vivo.	Aspartic Acid	46-55	aspartate/glutamate transporter	Saccharomyces cerevisiae S288C	8-12
11297557-4	2001	The p105 PEST domain contains a motif (Asp-Ser(927)-Gly-Val-Glu-Thr), related to the IKK target sequence in IkappaBalpha, which is conserved between human, mouse, rat, and chicken p105.	Aspartic Acid	39-42	NFKB inhibitor alpha	Homo sapiens	108-120
11297557-4	2001	The p105 PEST domain contains a motif (Asp-Ser(927)-Gly-Val-Glu-Thr), related to the IKK target sequence in IkappaBalpha, which is conserved between human, mouse, rat, and chicken p105.	Aspartic Acid	39-42	nuclear factor kappa B subunit 1	Homo sapiens	180-184
11320079-5	2001	We have shown recently that the conserved aspartate is involved in FDH catalysis.	Aspartic Acid	42-51	aldehyde dehydrogenase 1 family member L1	Homo sapiens	67-70
11320079-7	2001	Site-directed mutagenesis experiments showed that replacement of the histidine with alanine, asparagine, aspartate, glutamate, glutamine, or arginine in N(t)-FDH resulted in expression of insoluble proteins.	Aspartic Acid	105-114	aldehyde dehydrogenase 1 family member L1	Homo sapiens	153-161
11297557-4	2001	The p105 PEST domain contains a motif (Asp-Ser(927)-Gly-Val-Glu-Thr), related to the IKK target sequence in IkappaBalpha, which is conserved between human, mouse, rat, and chicken p105.	Aspartic Acid	39-42	nuclear factor kappa B subunit 1	Homo sapiens	4-8
11312274-8	2001	In the TSHr, the conformation of this Asn residue of TM7 would be constrained, in the inactive state, by its Asp partner in TM6.	Aspartic Acid	109-112	thyroid stimulating hormone receptor	Homo sapiens	7-11
11350743-4	2001	Twisting integrin receptors with RGD (Arg-Gly-Asp)-containing peptide-coated beads increased endothelin-1 (ET-1) gene expression by &gt;100%.	Aspartic Acid	46-49	endothelin 1	Homo sapiens	93-105
11389594-2	2001	This enediolic intermediate is formed from the abstraction of the pro-S C3 proton of DHAP by Asp-71 of MGS or the pro-R C3 proton of DHAP by Glu-165 of TIM.	Aspartic Acid	93-96	triosephosphate isomerase 1	Homo sapiens	152-155
11399059-9	2001	The IEC adhesion to FN was inhibited by specific antibody against the FN receptor (VLA-5), as well as competitive Arg-Gly-Asp (RGD) peptide.	Aspartic Acid	122-125	fibronectin 1	Mus musculus	20-22
11378370-2	2001	Fibronectin contains the active sequence Arg-Gly-Asp (RGD), along with its synergic site Pro-His-Ser-Arg-Asn (PHSRN).	Aspartic Acid	49-52	fibronectin 1	Homo sapiens	0-11
11394910-4	2001	Coimmunoprecipitation assays demonstrated that the interaction of RbAp46 with BRCA1 requires the first two of the four Trp-Asp (WD)-repeats of RbAp46.	Aspartic Acid	123-126	RB binding protein 7, chromatin remodeling factor	Homo sapiens	66-72
11394910-4	2001	Coimmunoprecipitation assays demonstrated that the interaction of RbAp46 with BRCA1 requires the first two of the four Trp-Asp (WD)-repeats of RbAp46.	Aspartic Acid	123-126	BRCA1 DNA repair associated	Homo sapiens	78-83
11394910-4	2001	Coimmunoprecipitation assays demonstrated that the interaction of RbAp46 with BRCA1 requires the first two of the four Trp-Asp (WD)-repeats of RbAp46.	Aspartic Acid	123-126	RB binding protein 7, chromatin remodeling factor	Homo sapiens	143-149
11522434-10	2001	However, alcohol-dependent subjects with the Asp allele showed a significantly higher GH response at day 7 after alcohol withdrawal and a tendency to lower novelty seeking.	Aspartic Acid	45-48	growth hormone 1	Homo sapiens	86-88
11350743-4	2001	Twisting integrin receptors with RGD (Arg-Gly-Asp)-containing peptide-coated beads increased endothelin-1 (ET-1) gene expression by &gt;100%.	Aspartic Acid	46-49	endothelin 1	Homo sapiens	107-111
11369651-5	2001	The phosphatidylinositol-3-kinase (PI-3K)/Akt pathway, but not the Ras-mediated mitogen-activated protein (MAP) kinase pathway, is also constitutively activated by Asp(816) mutant c-Kit.	Aspartic Acid	164-167	AKT serine/threonine kinase 1	Homo sapiens	42-45
11369651-0	2001	Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells.	Aspartic Acid	78-81	signal transducer and activator of transcription 3	Homo sapiens	0-50
11369651-5	2001	The phosphatidylinositol-3-kinase (PI-3K)/Akt pathway, but not the Ras-mediated mitogen-activated protein (MAP) kinase pathway, is also constitutively activated by Asp(816) mutant c-Kit.	Aspartic Acid	164-167	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	180-185
11369651-0	2001	Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells.	Aspartic Acid	78-81	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	94-99
11369651-1	2001	Activating mutations of c-kit at codon 816 (Asp(816)) have been implicated in a variety of malignancies, including acute myeloid leukemia (AML).	Aspartic Acid	44-47	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	24-29
11369651-3	2001	Changes in the signal transduction pathways responsible for Asp(816) mutant c-Kit-mediated biologic effects are largely undefined.	Aspartic Acid	60-63	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	76-81
11369651-9	2001	The investigation of altered signal transduction pathways and the resulting functional consequences mediated by Asp(816) mutant c-Kit should provide important information for the characterization of subsets of leukemia and potential molecular pathways for therapeutic targeting.	Aspartic Acid	112-115	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	128-133
11422390-9	2001	Bovine ZPA was processed between Ala and Asp on fertilization, suggesting that the consensus motif for the processing is Ala-Asp-Asp/Glu.	Aspartic Acid	41-44	zona pellucida glycoprotein 2	Homo sapiens	7-10
11369651-4	2001	The results of this study show that Asp(816) mutant c-Kit induces constitutive activation of signal transducer and activator of transcription 3 (STAT3) and STAT1, and up-regulates STAT3 downstream targets, Bcl-x(L) and c-myc.	Aspartic Acid	36-39	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	52-57
11369651-4	2001	The results of this study show that Asp(816) mutant c-Kit induces constitutive activation of signal transducer and activator of transcription 3 (STAT3) and STAT1, and up-regulates STAT3 downstream targets, Bcl-x(L) and c-myc.	Aspartic Acid	36-39	signal transducer and activator of transcription 3	Homo sapiens	93-143
11369651-4	2001	The results of this study show that Asp(816) mutant c-Kit induces constitutive activation of signal transducer and activator of transcription 3 (STAT3) and STAT1, and up-regulates STAT3 downstream targets, Bcl-x(L) and c-myc.	Aspartic Acid	36-39	signal transducer and activator of transcription 3	Homo sapiens	145-150
11369651-4	2001	The results of this study show that Asp(816) mutant c-Kit induces constitutive activation of signal transducer and activator of transcription 3 (STAT3) and STAT1, and up-regulates STAT3 downstream targets, Bcl-x(L) and c-myc.	Aspartic Acid	36-39	signal transducer and activator of transcription 1	Homo sapiens	156-161
11369651-4	2001	The results of this study show that Asp(816) mutant c-Kit induces constitutive activation of signal transducer and activator of transcription 3 (STAT3) and STAT1, and up-regulates STAT3 downstream targets, Bcl-x(L) and c-myc.	Aspartic Acid	36-39	signal transducer and activator of transcription 3	Homo sapiens	180-185
11369651-4	2001	The results of this study show that Asp(816) mutant c-Kit induces constitutive activation of signal transducer and activator of transcription 3 (STAT3) and STAT1, and up-regulates STAT3 downstream targets, Bcl-x(L) and c-myc.	Aspartic Acid	36-39	BCL2 like 1	Homo sapiens	206-214
11369651-4	2001	The results of this study show that Asp(816) mutant c-Kit induces constitutive activation of signal transducer and activator of transcription 3 (STAT3) and STAT1, and up-regulates STAT3 downstream targets, Bcl-x(L) and c-myc.	Aspartic Acid	36-39	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	219-224
11369651-5	2001	The phosphatidylinositol-3-kinase (PI-3K)/Akt pathway, but not the Ras-mediated mitogen-activated protein (MAP) kinase pathway, is also constitutively activated by Asp(816) mutant c-Kit.	Aspartic Acid	164-167	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-33
11375896-7	2001	In addition, we studied an A--&gt;G polymorphism in codon 312 of exon 10, which results in an Asp--&gt;Asn substitution in a conserved region of XPD.	Aspartic Acid	94-97	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	145-148
11395927-6	2001	We report here that ASP stimulates amylin release in both the HIT-T15 beta-cell line and human pancreatic islets in the presence of a wide range of glucose concentrations (0-16.7 mmol/L), similar to its effect on insulin release; this effect was blocked by 30 mumol/L nitrendipine, confirming a Ca(2+)-dependent mechanism.	Aspartic Acid	20-23	islet amyloid polypeptide	Mesocricetus auratus	35-41
11569502-2	2001	Aspartate kinase (AK) is a key enzyme in the biosynthsis of aspartate family amino acids such as lysine, threonine, isoleucine, and methionine.	Aspartic Acid	60-69	Aspartate kinase family protein	Arabidopsis thaliana	0-16
11389907-2	2001	Substitution of glycine-91 by site-directed mutagenesis with either aspartate or alanine resulted in a significant decrease in transport activity of GLUT1 expressed in Xenopus oocytes.	Aspartic Acid	68-77	solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog	Xenopus laevis	149-154
11569502-2	2001	Aspartate kinase (AK) is a key enzyme in the biosynthsis of aspartate family amino acids such as lysine, threonine, isoleucine, and methionine.	Aspartic Acid	60-69	Aspartate kinase family protein	Arabidopsis thaliana	18-20
11420045-4	2001	This inhibition is absolutely dependent on Asp-48 in 100K, found within a classic GrB consensus motif.	Aspartic Acid	43-46	granzyme B	Homo sapiens	82-85
11278311-6	2001	Peptide substrates based on the P4-P4" PI-9 RCL sequence and containing either P1 Glu or P1 Asp were cleaved by granzyme B (k(cat)/K(m) 9.5 x 10(3) and 1.2 x 10(5) s(-1) M(-1), respectively) but were not recognized by caspases.	Aspartic Acid	92-95	granzyme B	Homo sapiens	112-122
11397844-6	2001	Migration stimulation by IGFBP-1 was abrogated by pretreatment with a Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), but not a Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) hexapeptide, and by mutation of the RGD domain of IGFBP-1 to Trp-Gly-Asp (WGD).	Aspartic Acid	82-85	insulin like growth factor binding protein 1	Homo sapiens	25-32
11397844-6	2001	Migration stimulation by IGFBP-1 was abrogated by pretreatment with a Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), but not a Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) hexapeptide, and by mutation of the RGD domain of IGFBP-1 to Trp-Gly-Asp (WGD).	Aspartic Acid	82-85	insulin like growth factor binding protein 1	Homo sapiens	197-204
11359853-7	2001	Moreover, we found that Tet- and Tripterygium wilfordii hook F-induced T cell DNA damage required caspase-3 activity, and hydroxychloroquine-induced T cell DNA damage was mediated through a caspase-3- and caspase-8-independent, but Z-Asp-Glu-Val-Asp-fluomethyl ketone-sensitive, signaling pathway.	Aspartic Acid	234-237	caspase 3	Homo sapiens	190-199
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Aspartic Acid	339-342	growth hormone receptor	Homo sapiens	12-35
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Aspartic Acid	339-342	growth hormone receptor	Homo sapiens	37-40
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Aspartic Acid	339-342	growth hormone receptor	Homo sapiens	191-194
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Aspartic Acid	339-342	growth hormone 1	Homo sapiens	37-39
11402452-3	2001	RESULTS: The phenotypes of Ile/Ile, Asp/Asp were over-presented for TAP1 and Val/Val, Ala/Thr, Stop/Stop for TAP2 in Han nationality.	Aspartic Acid	36-39	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	68-72
11402452-3	2001	RESULTS: The phenotypes of Ile/Ile, Asp/Asp were over-presented for TAP1 and Val/Val, Ala/Thr, Stop/Stop for TAP2 in Han nationality.	Aspartic Acid	36-39	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	109-113
11402452-3	2001	RESULTS: The phenotypes of Ile/Ile, Asp/Asp were over-presented for TAP1 and Val/Val, Ala/Thr, Stop/Stop for TAP2 in Han nationality.	Aspartic Acid	40-43	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	68-72
11402452-3	2001	RESULTS: The phenotypes of Ile/Ile, Asp/Asp were over-presented for TAP1 and Val/Val, Ala/Thr, Stop/Stop for TAP2 in Han nationality.	Aspartic Acid	40-43	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	109-113
11278904-1	2001	The crystal structure of yeast orotidine-5"-phosphate decarboxylase in complex with the postulated transition state analog, 6-hydroxyuridine-5"-phosphate, reveals contacts between this inhibitor and a novel quartet of charged residues (Lys-59, Asp-91, Lys-93, and Asp-96) within the active site.	Aspartic Acid	244-247	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	31-67
11278904-1	2001	The crystal structure of yeast orotidine-5"-phosphate decarboxylase in complex with the postulated transition state analog, 6-hydroxyuridine-5"-phosphate, reveals contacts between this inhibitor and a novel quartet of charged residues (Lys-59, Asp-91, Lys-93, and Asp-96) within the active site.	Aspartic Acid	264-267	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	31-67
11381044-1	2001	PURPOSE: To determine whether substitution of the potential phosphorylation sites of bovine rhodopsin"s carboxyl-terminal region with the acidic residues aspartic acid, glutamic acid, or cysteic acid promotes the activation of arrestin.	Aspartic Acid	154-167	rhodopsin	Bos taurus	92-101
11397844-4	2001	The present study examined whether this stimulation is dependent on binding of the Arg-Gly-Asp (RGD) domain of IGFBP-1 to an RGD binding site on the alpha 5 beta 1 integrin, followed by activation of focal adhesion kinase (FAK) and stimulation of the mitogen-activated protein kinase (MAPK) pathway.	Aspartic Acid	91-94	insulin like growth factor binding protein 1	Homo sapiens	111-118
11402167-10	2001	Combining the Thr(168)-to-Asp mutation with the autoinhibitory domain deletion created a superactive SOS2 kinase.	Aspartic Acid	26-29	Protein kinase superfamily protein	Arabidopsis thaliana	101-105
11376598-0	2001	Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase.	Aspartic Acid	42-51	catalase	Rattus norvegicus	116-124
11376598-9	2001	In contrast, the antioxidant catalase (1000 U/ml) significantly attenuated methylmercury-induced inhibition of 3H-aspartate uptake, suggesting that excess reactive oxygen species, specifically H2O2, inhibit the function of an astrocytic excitatory amino acid transporter (EAAT1).	Aspartic Acid	114-123	catalase	Rattus norvegicus	29-37
11278615-10	2001	The critical aspartate residue required for eicosanoid sensitivity is the same residue required for Na(+) regulation of PIP(2) gating.	Aspartic Acid	13-22	prolactin induced protein	Homo sapiens	120-123
11278311-8	2001	An idealized substrate comprising the previously described optimal P4-P1 sequence (Ile-Glu-Pro-Asp) fused to the PI-9 P1"-P4" sequence was efficiently cleaved by granzyme B (k(cat)/K(m) 7.5 x 10(5) s(-1) M(-1)) and was also recognized by caspases.	Aspartic Acid	95-98	granzyme B	Homo sapiens	162-172
11377692-1	2001	The N-terminal region of bovine serum albumin (Asp-Thr-His-Lys) is known to provide a specific binding site for Cu(II) ions, with the histidine residue thought to be mainly responsible for the specificity.	Aspartic Acid	47-50	albumin	Homo sapiens	32-45
11378569-2	2001	We have identified activating mutations of c-kit at codon 816 (Asp(816) ) from a revertant of the cytokine-dependent acute myeloid leukemia (AML) cell line, MO7e (D816H), and de novo childhood AML (D816N).	Aspartic Acid	63-66	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	43-48
11378569-5	2001	These results suggest a potentially important role of Asp(816) mutations of c-kit in both malignant cell proliferation and resistance to therapy.	Aspartic Acid	54-57	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	76-81
11278266-8	2001	We propose that the pore of IP(3)R channels has two distinct sites that control monovalent cation permeation (Val(2548)) and Ca(2+) selectivity (Asp(2550)).	Aspartic Acid	145-148	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-34
11359571-7	2001	The presence of the neighbouring part of the C-terminus (amino acids 883-928), rich in aspartate and glutamate residues, is necessary for the maintenance of maximum Nha1p activity towards sodium and lithium.	Aspartic Acid	87-96	Nha1p	Saccharomyces cerevisiae S288C	165-170
11331301-1	2001	The P2Y(2) nucleotide receptor (P2Y(2)R) contains the integrin-binding domain arginine-glycine-aspartic acid (RGD) in its first extracellular loop, raising the possibility that this G protein-coupled receptor interacts directly with an integrin.	Aspartic Acid	95-108	purinergic receptor P2Y2	Homo sapiens	4-30
11331301-1	2001	The P2Y(2) nucleotide receptor (P2Y(2)R) contains the integrin-binding domain arginine-glycine-aspartic acid (RGD) in its first extracellular loop, raising the possibility that this G protein-coupled receptor interacts directly with an integrin.	Aspartic Acid	95-108	purinergic receptor P2Y2	Homo sapiens	32-39
11322950-2	2001	Here, we describe that the 65 C-terminal amino acids of STAT3 can function as an independent transcription activation domain (TAD), particularly when a negative charge is introduced at position 727 by mutation of the serine residue into aspartate.	Aspartic Acid	237-246	signal transducer and activator of transcription 3	Homo sapiens	56-61
11278590-6	2001	In the x-ray structure, colipase has a hydrophobic surface positioned to bind substrate and a hydrophilic surface, lying opposite the hydrophobic surface, with two putative lipase-binding domains, Glu(45)/Asp(89) and Glu(64)/Arg(65).	Aspartic Acid	205-208	colipase	Homo sapiens	24-32
11152692-6	2001	Instead, asporin contains a unique stretch of aspartic acid residues in its amino-terminal region.	Aspartic Acid	46-59	asporin	Homo sapiens	9-16
11472112-9	2001	From the results, the conserved water molecule, corresponding to W206 in the E. coli DHFR complexes, that is H-bonded to both the OD2 oxygen atom of the carboxyl (Asp) side chain and O4 of the pterin/dihydropterin ring, appears critically important and may determine the protonation site for the enzyme-bound substrates.	Aspartic Acid	163-166	Dihydrofolate reductase	Escherichia coli	85-89
11121422-1	2001	The crystal structure of heme oxygenase-1 suggests that Asp-140 may participate in a hydrogen bonding network involving ligands coordinated to the heme iron atom.	Aspartic Acid	56-59	heme oxygenase 1	Homo sapiens	25-41
11284696-0	2001	Transition state analysis and requirement of Asp-262 general acid/base catalyst for full activation of dual-specificity phosphatase MKP3 by extracellular regulated kinase.	Aspartic Acid	45-48	dual specificity phosphatase 6	Homo sapiens	132-136
11284696-0	2001	Transition state analysis and requirement of Asp-262 general acid/base catalyst for full activation of dual-specificity phosphatase MKP3 by extracellular regulated kinase.	Aspartic Acid	45-48	mitogen-activated protein kinase 1	Homo sapiens	140-170
11284696-4	2001	Here, we investigated whether Asp-262 of MKP3 is the bona fide general acid and evaluated its contribution to the catalytic steps activated by ERK.	Aspartic Acid	30-33	dual specificity phosphatase 6	Homo sapiens	41-45
11284696-4	2001	Here, we investigated whether Asp-262 of MKP3 is the bona fide general acid and evaluated its contribution to the catalytic steps activated by ERK.	Aspartic Acid	30-33	mitogen-activated protein kinase 1	Homo sapiens	143-146
11256967-1	2001	The translation eukaryotic initiation factor (eIF)4G of the yeast Saccharomyces cerevisiae interacts with the RNA helicase eIF4A (a member of the DEAD-box protein family; where DEAD corresponds to Asp-Glu-Ala-Asp) through a C-terminal domain in eIF4G (amino acids 542-883).	Aspartic Acid	197-200	eukaryotic translation initiation factor 4A1	Homo sapiens	123-128
11285231-4	2001	Substitution of this residue by aspartate (E2100D) results in a 10-fold decrease in the Ca(2+) sensitivity without other effects on the properties of the IP(3)R1.	Aspartic Acid	32-41	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	154-161
11417227-3	2001	The amino acid transport activity induced by the co-expression of human 4F2hc and xCT in Xenopus oocytes was sodium independent and specific for L-cystine, L-glutamate and L-aspartate.	Aspartic Acid	172-183	solute carrier family 3 member 2	Homo sapiens	72-77
11417227-3	2001	The amino acid transport activity induced by the co-expression of human 4F2hc and xCT in Xenopus oocytes was sodium independent and specific for L-cystine, L-glutamate and L-aspartate.	Aspartic Acid	172-183	solute carrier family 7 member 11	Homo sapiens	82-85
11287119-4	2001	In this report, we show that the C-terminal deletion and two point mutations (Asp--&gt;Gly at residue 91 and Asp--&gt;Asn at residue 437) in v-Rel make it resistant to cleavage by the cell-death protease caspase-3.	Aspartic Acid	78-81	caspase 3	Gallus gallus	204-213
11287119-4	2001	In this report, we show that the C-terminal deletion and two point mutations (Asp--&gt;Gly at residue 91 and Asp--&gt;Asn at residue 437) in v-Rel make it resistant to cleavage by the cell-death protease caspase-3.	Aspartic Acid	109-112	caspase 3	Gallus gallus	204-213
11287119-5	2001	In contrast, c-Rel, which has Asp residues at these sites, can be cleaved by caspase-3 in vitro as well as in vivo in cells induced to undergo apoptosis.	Aspartic Acid	30-33	REL proto-oncogene, NF-kB subunit	Homo sapiens	13-18
11287119-5	2001	In contrast, c-Rel, which has Asp residues at these sites, can be cleaved by caspase-3 in vitro as well as in vivo in cells induced to undergo apoptosis.	Aspartic Acid	30-33	caspase 3	Gallus gallus	77-86
11256967-1	2001	The translation eukaryotic initiation factor (eIF)4G of the yeast Saccharomyces cerevisiae interacts with the RNA helicase eIF4A (a member of the DEAD-box protein family; where DEAD corresponds to Asp-Glu-Ala-Asp) through a C-terminal domain in eIF4G (amino acids 542-883).	Aspartic Acid	197-200	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	245-250
11256967-1	2001	The translation eukaryotic initiation factor (eIF)4G of the yeast Saccharomyces cerevisiae interacts with the RNA helicase eIF4A (a member of the DEAD-box protein family; where DEAD corresponds to Asp-Glu-Ala-Asp) through a C-terminal domain in eIF4G (amino acids 542-883).	Aspartic Acid	209-212	eukaryotic translation initiation factor 4A1	Homo sapiens	123-128
11256970-1	2001	Bovine DNase I contains two potential N-linked glycosylation sites with the sequences Asn(18)-Ala-Thr and Asn(106)-Asp-Ser.	Aspartic Acid	115-118	deoxyribonuclease 1	Bos taurus	7-14
11285194-3	2001	The XPD codon 312 Asp/Asp genotype was found to have almost twice the risk of lung cancer when the Asp/Asn + Asn/Asn combined genotype served as reference [odds ratio (OR) 1.86, 95% confidence interval (CI), 1.02-3.40].	Aspartic Acid	18-21	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
11285194-3	2001	The XPD codon 312 Asp/Asp genotype was found to have almost twice the risk of lung cancer when the Asp/Asn + Asn/Asn combined genotype served as reference [odds ratio (OR) 1.86, 95% confidence interval (CI), 1.02-3.40].	Aspartic Acid	22-25	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
11285194-3	2001	The XPD codon 312 Asp/Asp genotype was found to have almost twice the risk of lung cancer when the Asp/Asn + Asn/Asn combined genotype served as reference [odds ratio (OR) 1.86, 95% confidence interval (CI), 1.02-3.40].	Aspartic Acid	22-25	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
11285194-4	2001	In light cigarette smokers (less than the median of 34.5 pack-years), the XPD codon 312 Asp/Asp genotype was more frequent among cases than in controls and was associated with an increased risk of NSCLC.	Aspartic Acid	88-91	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	74-77
11285194-4	2001	In light cigarette smokers (less than the median of 34.5 pack-years), the XPD codon 312 Asp/Asp genotype was more frequent among cases than in controls and was associated with an increased risk of NSCLC.	Aspartic Acid	92-95	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	74-77
11325591-0	2001	The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.	Aspartic Acid	133-146	granzyme B	Homo sapiens	41-51
11325591-0	2001	The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.	Aspartic Acid	133-146	caspase 3	Homo sapiens	64-73
11325591-1	2001	BACKGROUND: Granzyme B, one of the most abundant granzymes in cytotoxic T-lymphocyte (CTL) granules, and members of the caspase (cysteine aspartyl proteinases) family have a unique cleavage specificity for aspartic acid in P1 and play critical roles in the biochemical events that culminate in cell death.	Aspartic Acid	206-219	granzyme B	Homo sapiens	12-22
11325591-3	2001	The Asp-specific S1 subsite of human granzyme B is significantly larger and less charged than the corresponding Asp-specific site in the apoptosis-promoting caspases, and also larger than the corresponding subsite in rat granzyme B.	Aspartic Acid	4-7	granzyme B	Homo sapiens	37-47
11325591-3	2001	The Asp-specific S1 subsite of human granzyme B is significantly larger and less charged than the corresponding Asp-specific site in the apoptosis-promoting caspases, and also larger than the corresponding subsite in rat granzyme B.	Aspartic Acid	4-7	granzyme B	Rattus norvegicus	221-231
11325591-3	2001	The Asp-specific S1 subsite of human granzyme B is significantly larger and less charged than the corresponding Asp-specific site in the apoptosis-promoting caspases, and also larger than the corresponding subsite in rat granzyme B.	Aspartic Acid	112-115	granzyme B	Homo sapiens	37-47
12214065-15	2001	Cathepsin D, which accumulates within AD neurons [15], also cleaves at the N-terminal side of the first aspartate residue of amyloid beta [2].beta-secretase activity is necessary in order to initiate 4kD beta1-x formation by cleaving AbetaPP at the N-terminus and results in the release of a soluble 100kD AbetaPP N- terminal fragment and a 12kD membrane bound C-terminal fragment (C99/C100) [55].	Aspartic Acid	104-113	cathepsin D	Homo sapiens	0-11
11398969-5	2001	Pig DAP10 has a conserved aspartic acid in the transmembrane domain, two cysteines in the extracellular domain, and a phophatidylinositol-3 kinase-binding site (YxxM) in the cytoplasmic region.	Aspartic Acid	26-39	hematopoietic cell signal transducer	Sus scrofa	4-9
11133982-4	2001	Val-Stat5 produced a 5-fold higher increase in transcriptional activity relative to Thr-Stat5; Asp-Stat5 produced a similar response to Thr-Stat5.	Aspartic Acid	95-98	signal transducer and activator of transcription 5A	Homo sapiens	136-145
11124960-7	2001	Moreover, residues (Glu(36), Trp(67), Asp(68), Trp(73), and Gly(109)) which were shown to be crucial for VIP binding are gathered around a groove that is essentially negatively charged.	Aspartic Acid	38-41	vasoactive intestinal peptide	Homo sapiens	105-108
11315825-7	2001	HLA oligotyping showed that gene frequencies of non-Asp-57 (of the HLA-DQB chain) in the patients (0.94) and control subjects (0.6) were similar to those of other populations with a known high incidence of type 1 diabetes.	Aspartic Acid	52-55	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	67-74
11283617-8	2001	Here, we show that Asp is the previously identified Mr 220K substrate of Polo kinase.	Aspartic Acid	19-22	polo	Drosophila melanogaster	73-77
11283617-9	2001	Polo phosphorylates Asp in vitro, converting it into an MPM2 epitope.	Aspartic Acid	20-23	polo	Drosophila melanogaster	0-4
11283617-9	2001	Polo phosphorylates Asp in vitro, converting it into an MPM2 epitope.	Aspartic Acid	20-23	multi sex combs	Drosophila melanogaster	56-60
11133982-7	2001	The serine-threonine kinase inhibitor H7 inhibited the transactivation potential of Thr-, Val-, and Asp-Stat5 to a similar extent, eliminating phosphorylation of Thr(757) as a regulatory mechanism.	Aspartic Acid	100-103	signal transducer and activator of transcription 5A	Homo sapiens	104-109
11258943-6	2001	Modeling suggests that Asp in position 306 prevents the TF-induced stimulation of FVIIa by disrupting essential intermolecular hydrogen bonds.	Aspartic Acid	23-26	coagulation factor III, tissue factor	Homo sapiens	56-58
11238646-3	2001	We have previously reported that residue Asp(112) of CRP plays a major role in the formation of the C1q-binding site, while the neighboring Lys(114) hinders C1q binding.	Aspartic Acid	41-44	C-reactive protein	Homo sapiens	53-56
11401448-4	2001	CNRc1 and c2 lack the Arg-Gly-Asp (RGD) sequence that is conserved in the EC1 of CNR1-8, which is necessary for binding to Reelin.	Aspartic Acid	30-33	protocadherin alpha subfamily C, 1	Mus musculus	0-5
11401448-4	2001	CNRc1 and c2 lack the Arg-Gly-Asp (RGD) sequence that is conserved in the EC1 of CNR1-8, which is necessary for binding to Reelin.	Aspartic Acid	30-33	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	74-77
11243808-3	2001	CheA-CheY phosphotransfer generates phospho-CheY, CheY-P. Aspartate triggers smooth swim responses by inactivation of the CheA bound to the target MCP, Tar; but this mechanism alone cannot explain the observed response sensitivity.	Aspartic Acid	58-67	mcp	Escherichia coli	147-150
11401448-4	2001	CNRc1 and c2 lack the Arg-Gly-Asp (RGD) sequence that is conserved in the EC1 of CNR1-8, which is necessary for binding to Reelin.	Aspartic Acid	30-33	cannabinoid receptor 1	Homo sapiens	81-87
11238646-3	2001	We have previously reported that residue Asp(112) of CRP plays a major role in the formation of the C1q-binding site, while the neighboring Lys(114) hinders C1q binding.	Aspartic Acid	41-44	complement C1q A chain	Homo sapiens	100-103
11401448-4	2001	CNRc1 and c2 lack the Arg-Gly-Asp (RGD) sequence that is conserved in the EC1 of CNR1-8, which is necessary for binding to Reelin.	Aspartic Acid	30-33	reelin	Homo sapiens	123-129
11238646-7	2001	Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp(112) and Tyr(175) are important contact residues for C1q binding, that Glu(88) influences the conformational change in C1q necessary for complement activation, and that Asn(158) and His(38) probably contribute to the correct geometry of the binding site.	Aspartic Acid	96-99	complement C1q A chain	Homo sapiens	153-156
11238646-7	2001	Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp(112) and Tyr(175) are important contact residues for C1q binding, that Glu(88) influences the conformational change in C1q necessary for complement activation, and that Asn(158) and His(38) probably contribute to the correct geometry of the binding site.	Aspartic Acid	96-99	complement C1q A chain	Homo sapiens	219-222
11237766-2	2001	Asp-96 in MPO, a residue next to the histidine distal from the heme prosthetic group, has been assigned to the calcium-binding site of the enzyme by X-ray crystallography.	Aspartic Acid	0-3	myeloperoxidase	Homo sapiens	10-13
11237766-4	2001	In this study, we replaced Asp-96 in MPO and the counterpart Asp-227 in LPO both with Ala by site-directed mutagenesis.	Aspartic Acid	61-64	lactoperoxidase	Homo sapiens	72-75
11355082-9	2001	This implies that both aspartic acid and glutamic acid residues, which have the carboxyl group, may play an important role when PR binds with steroid ligands.	Aspartic Acid	23-36	progesterone receptor	Homo sapiens	128-130
11255023-1	2001	Queuosine (Q) is a 7-deazaguanosine found in the first position of the anticodon of tRNAs that recognize NAU and NAC codons (Tyr, Asn, Asp and His).	Aspartic Acid	135-138	X-linked Kx blood group	Homo sapiens	113-116
11104775-7	2001	The most important residue in the KIM sequence of MKP3 is Arg(65), which probably interacts with Asp(319) in ERK2.	Aspartic Acid	97-100	dual specificity phosphatase 6	Homo sapiens	50-54
11104775-7	2001	The most important residue in the KIM sequence of MKP3 is Arg(65), which probably interacts with Asp(319) in ERK2.	Aspartic Acid	97-100	mitogen-activated protein kinase 1	Homo sapiens	109-113
11056162-3	2001	We report here the solution structure of the human MAT1 RING finger domain (Met(1)-Asp(65)) as determined by (1)H NMR spectroscopy.	Aspartic Acid	83-86	MNAT1 component of CDK activating kinase	Homo sapiens	51-55
11078728-1	2001	Serine protease activation is typically controlled by proteolytic cleavage of the scissile bond, resulting in spontaneous formation of the activating Ile(16)-Asp(194) salt bridge.	Aspartic Acid	158-161	coagulation factor II, thrombin	Homo sapiens	0-15
11282454-10	2001	These results demonstrate an important role of the aspartate at position 440 in determining substrate specificity and inhibitor susceptibility of PDE4A.	Aspartic Acid	51-60	phosphodiesterase 4A	Homo sapiens	146-151
11230124-3	2001	We propose a multi-step process, whereby catalytically active processed or unprocessed caspase-9 initially binds the Apaf-1 apoptosome in cytochrome c/dATP-activated lysates and consequently recruits caspase-3 via an interaction between the active site cysteine (C287) in caspase-9 and a critical aspartate (D175) in caspase-3.	Aspartic Acid	297-306	caspase 9	Homo sapiens	87-96
11238294-7	2001	RESULTS: One of the patient"s sisters had a missense mutation (Asp(407)--&gt;Lys) in exon 9 of the LDL receptor and a serum LDL-cholesterol concentration of 4.07 mmol/L.	Aspartic Acid	63-66	low density lipoprotein receptor	Homo sapiens	99-111
11230124-3	2001	We propose a multi-step process, whereby catalytically active processed or unprocessed caspase-9 initially binds the Apaf-1 apoptosome in cytochrome c/dATP-activated lysates and consequently recruits caspase-3 via an interaction between the active site cysteine (C287) in caspase-9 and a critical aspartate (D175) in caspase-3.	Aspartic Acid	297-306	apoptotic peptidase activating factor 1	Homo sapiens	117-123
11230124-3	2001	We propose a multi-step process, whereby catalytically active processed or unprocessed caspase-9 initially binds the Apaf-1 apoptosome in cytochrome c/dATP-activated lysates and consequently recruits caspase-3 via an interaction between the active site cysteine (C287) in caspase-9 and a critical aspartate (D175) in caspase-3.	Aspartic Acid	297-306	cytochrome c, somatic	Homo sapiens	138-150
11230124-3	2001	We propose a multi-step process, whereby catalytically active processed or unprocessed caspase-9 initially binds the Apaf-1 apoptosome in cytochrome c/dATP-activated lysates and consequently recruits caspase-3 via an interaction between the active site cysteine (C287) in caspase-9 and a critical aspartate (D175) in caspase-3.	Aspartic Acid	297-306	caspase 3	Homo sapiens	200-209
11241847-5	2001	Sequencing of the entire coding region of the EPO gene disclosed a novel mutation, a 2060 G-A transition (g. 2060G&gt;A) causing an amino acid change from aspartic acid to asparagine (D648N).	Aspartic Acid	155-168	eosinophil peroxidase	Homo sapiens	46-49
11260266-1	2001	BACKGROUND: Coronin is an actin-binding protein, which contains WD (Trp-Asp) repeats and a coiled-coil motif, and plays a role in regulating organization of the actin cytoskeletal network.	Aspartic Acid	72-75	coronin 1C L homeolog	Xenopus laevis	12-19
11307817-2	2001	Comparison of the gamma" amino acid sequence (VRPEHPAETEYDSLYPEDDL) with other protein sequences known to bind to thrombin exosites such as those in GPIbalpha, the platelet thrombin receptor, thrombomodulin, and hirudin suggests no homology or consensus sequences, but Glu and Asp enrichment are common to all.	Aspartic Acid	277-280	coagulation factor II, thrombin	Homo sapiens	114-122
11344332-1	2001	Threonine synthase (TS) is a PLP-dependent enzyme that catalyzes the last reaction in the synthesis of threonine from aspartate.	Aspartic Acid	118-127	Pyridoxal-5'-phosphate-dependent enzyme family protein	Arabidopsis thaliana	0-18
11344332-1	2001	Threonine synthase (TS) is a PLP-dependent enzyme that catalyzes the last reaction in the synthesis of threonine from aspartate.	Aspartic Acid	118-127	Pyridoxal-5'-phosphate-dependent enzyme family protein	Arabidopsis thaliana	20-22
11344332-1	2001	Threonine synthase (TS) is a PLP-dependent enzyme that catalyzes the last reaction in the synthesis of threonine from aspartate.	Aspartic Acid	118-127	PAS/LOV protein B	Arabidopsis thaliana	29-32
11239577-4	2001	The first three-dimensional structure of the unique NAT family shows the active-site cysteine to be aligned with conserved histidine and aspartate residues to form a catalytic triad, thus providing an activation mechanism for transfer of the acetyl group from acetyl CoA to cysteine.	Aspartic Acid	137-146	bromodomain containing 2	Homo sapiens	52-55
11307817-2	2001	Comparison of the gamma" amino acid sequence (VRPEHPAETEYDSLYPEDDL) with other protein sequences known to bind to thrombin exosites such as those in GPIbalpha, the platelet thrombin receptor, thrombomodulin, and hirudin suggests no homology or consensus sequences, but Glu and Asp enrichment are common to all.	Aspartic Acid	277-280	glycoprotein Ib platelet subunit alpha	Homo sapiens	149-158
11024043-7	2001	Since the interaction between Asp(276) and the nascent base pair is observed only in the "closed" conformation of pol beta, the increased free energy in ground-state binding for the mutant suggests that the subsequent rate-limiting conformational change is not the "open" to "closed" structural transition, but instead is triggered in the closed pol conformation.	Aspartic Acid	30-33	DNA polymerase beta	Homo sapiens	114-122
11178968-5	2001	The comparative modeling of active sites from caspase-3 and CED3 protein indicated that although these enzymes require Asp at the position P4, variation could occur in the binding of this residue at the S4 subsite.	Aspartic Acid	119-122	Cell death protein 3 subunit p17	Caenorhabditis elegans	60-64
11170182-5	2001	Pretreatment with Gly-Arg-Gly-Asp-Ser peptide inhibited the SSC increasing action of 12-o-tetradecanoyl-phorbol-13-acetate (TPA, 0.5 microM) plus fibronectin, but not that of TPA plus laminin.	Aspartic Acid	30-33	fibronectin 1 S homeolog	Xenopus laevis	146-157
11024043-0	2001	DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta.	Aspartic Acid	18-27	DNA polymerase beta	Homo sapiens	70-89
11226253-5	2001	The ARF-GEP(100) Sec7 domain contains Asp(543) and Met(555), corresponding to residues associated with sensitivity to the inhibitory effect of the fungal metabolite brefeldin A (BFA) in yeast Sec7, but also Phe(535) and Ala(536), associated with BFA-insensitivity.	Aspartic Acid	38-41	granulin precursor	Homo sapiens	8-11
11226253-5	2001	The ARF-GEP(100) Sec7 domain contains Asp(543) and Met(555), corresponding to residues associated with sensitivity to the inhibitory effect of the fungal metabolite brefeldin A (BFA) in yeast Sec7, but also Phe(535) and Ala(536), associated with BFA-insensitivity.	Aspartic Acid	38-41	Arf family guanine nucleotide exchange factor SEC7	Saccharomyces cerevisiae S288C	17-21
11226253-5	2001	The ARF-GEP(100) Sec7 domain contains Asp(543) and Met(555), corresponding to residues associated with sensitivity to the inhibitory effect of the fungal metabolite brefeldin A (BFA) in yeast Sec7, but also Phe(535) and Ala(536), associated with BFA-insensitivity.	Aspartic Acid	38-41	Arf family guanine nucleotide exchange factor SEC7	Saccharomyces cerevisiae S288C	192-196
11178964-2	2001	Caspases, the major effectors of apoptosis, are cysteine proteases that cleave crucial substrate proteins exclusively after aspartate residues.	Aspartic Acid	124-133	caspase 8	Homo sapiens	0-8
11368342-8	2001	At position 2, substitution of Leu by Cha or Phe gave equivalent PAR-2 potency, but this modification also activated PAR-1, whereas Ala, Asp, Lys, or Gln abolished PAR-2 activity; at position 3, Ile and Cha were optimal, although various amino acids were tolerated; at position 4, Ala or Cha increased PAR-2 potency 2-fold, although Cha introduced PAR-1 activity; at position 5, Arg or Lys could be replaced successfully by large hydrophobic amino acids.	Aspartic Acid	137-140	F2R like trypsin receptor 1	Homo sapiens	164-169
11368342-8	2001	At position 2, substitution of Leu by Cha or Phe gave equivalent PAR-2 potency, but this modification also activated PAR-1, whereas Ala, Asp, Lys, or Gln abolished PAR-2 activity; at position 3, Ile and Cha were optimal, although various amino acids were tolerated; at position 4, Ala or Cha increased PAR-2 potency 2-fold, although Cha introduced PAR-1 activity; at position 5, Arg or Lys could be replaced successfully by large hydrophobic amino acids.	Aspartic Acid	137-140	F2R like trypsin receptor 1	Homo sapiens	164-169
11159857-13	2001	Using computer-assisted molecular models of ER complexes, we found that the antiestrogenic side chain of 4-OHT weakly interacted with the surface amino acid 351 (aspartate), but the carboxylic acid of GW7604 caused a strong repulsion of aspartate 351.	Aspartic Acid	162-171	estrogen receptor 1	Homo sapiens	44-46
11239517-2	2001	There are two known polymorphisms in exon 11 of the DBP gene resulting in amino acid variants: codons 416 GAT --&gt; GAG (Asp --&gt; Glu) and 420 ACG --&gt; AAG (Thr --&gt; Lys).	Aspartic Acid	122-125	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
11239517-5	2001	RESULTS: A significant enrichment in DQB1 alleles encoding for an amino acid different from Asp in position 57 (NA) was observed in diabetic subjects as compared to controls (94.3 vs. 32.8%; p &lt; 0.001).	Aspartic Acid	92-95	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	37-41
11239517-10	2001	DBP alleles in individuals carrying the DQB1 NA combination revealed that 46.6% of diabetics were DBP Asp/Glu, but this was not statistically significant using the Fisher exact test (16/31 vs. 0/3; p = 0.23).	Aspartic Acid	102-105	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
11239517-10	2001	DBP alleles in individuals carrying the DQB1 NA combination revealed that 46.6% of diabetics were DBP Asp/Glu, but this was not statistically significant using the Fisher exact test (16/31 vs. 0/3; p = 0.23).	Aspartic Acid	102-105	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	40-44
11239517-10	2001	DBP alleles in individuals carrying the DQB1 NA combination revealed that 46.6% of diabetics were DBP Asp/Glu, but this was not statistically significant using the Fisher exact test (16/31 vs. 0/3; p = 0.23).	Aspartic Acid	102-105	D-box binding PAR bZIP transcription factor	Homo sapiens	98-101
11239517-11	2001	CONCLUSIONS: The study of the DQB1 chain confirmed the value of alleles encoding for an amino acid different from Asp in position 57 (NA) in the susceptibility to type 1 diabetes.	Aspartic Acid	114-117	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	30-34
11165234-4	2001	While the overall identity is not high, NOP shares several sequence similarities with mammalian and chicken osteopontins, including the percentage of aspartate, serine and alanine residues and the presence of a cell attachment motif.	Aspartic Acid	150-159	prepronociceptin	Homo sapiens	40-43
11159845-3	2001	The recent development of the PRL receptor antagonist S179D-PRL, a mutant of human PRL in which the serine residue at the 179 position is replaced with aspartate, provides a potentially useful tool to examine the role of PRL in neural processing.	Aspartic Acid	152-161	prolactin	Rattus norvegicus	30-33
11159845-3	2001	The recent development of the PRL receptor antagonist S179D-PRL, a mutant of human PRL in which the serine residue at the 179 position is replaced with aspartate, provides a potentially useful tool to examine the role of PRL in neural processing.	Aspartic Acid	152-161	prolactin	Homo sapiens	60-63
11159845-3	2001	The recent development of the PRL receptor antagonist S179D-PRL, a mutant of human PRL in which the serine residue at the 179 position is replaced with aspartate, provides a potentially useful tool to examine the role of PRL in neural processing.	Aspartic Acid	152-161	prolactin	Homo sapiens	60-63
11159845-3	2001	The recent development of the PRL receptor antagonist S179D-PRL, a mutant of human PRL in which the serine residue at the 179 position is replaced with aspartate, provides a potentially useful tool to examine the role of PRL in neural processing.	Aspartic Acid	152-161	prolactin	Homo sapiens	60-63
11159857-13	2001	Using computer-assisted molecular models of ER complexes, we found that the antiestrogenic side chain of 4-OHT weakly interacted with the surface amino acid 351 (aspartate), but the carboxylic acid of GW7604 caused a strong repulsion of aspartate 351.	Aspartic Acid	237-246	estrogen receptor 1	Homo sapiens	44-46
11174197-14	2001	Fourteen-week-old CHMCs significantly adhered to the leucine-aspartic acid-valine-containing connecting segment 1 fragment of fibronectin, the 120-kd argine-glycine-aspartic acid-containing fragment of fibronectin, vitronectin, and laminin through specific integrins.	Aspartic Acid	61-75	fibronectin 1	Homo sapiens	126-137
11311846-12	2001	N-methyl-D,L-aspartate and leptin stimulate the secretion of GHRH, while neuropeptide Y stimulates the secretion of GHRH and SS.	Aspartic Acid	11-22	growth hormone releasing hormone	Bos taurus	61-65
11174197-14	2001	Fourteen-week-old CHMCs significantly adhered to the leucine-aspartic acid-valine-containing connecting segment 1 fragment of fibronectin, the 120-kd argine-glycine-aspartic acid-containing fragment of fibronectin, vitronectin, and laminin through specific integrins.	Aspartic Acid	61-74	fibronectin 1	Homo sapiens	126-137
11160861-0	2001	Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells.	Aspartic Acid	15-18	mitogen-activated protein kinase kinase 1	Homo sapiens	58-99
11246655-0	2001	HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis.	Aspartic Acid	29-42	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
11160861-0	2001	Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells.	Aspartic Acid	15-18	BCL2 apoptosis regulator	Homo sapiens	161-166
11160861-0	2001	Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells.	Aspartic Acid	27-30	mitogen-activated protein kinase kinase 1	Homo sapiens	58-99
11160861-0	2001	Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells.	Aspartic Acid	27-30	BCL2 apoptosis regulator	Homo sapiens	161-166
11053423-3	2001	Main interaction sites are centered around Asp(79), Asp(76), Asp(72), and Asp(39) of Adx and around Arg(211), Arg(240), Arg(244), and Lys(27) of AR, respectively.	Aspartic Acid	43-46	ferredoxin 1	Homo sapiens	85-88
11230563-3	2001	By employing the well-known His--&gt;Asp phosphorelay systems in both the fission yeast and Escherichia coli, evidence is presented showing that the AHK4 His-kinase has an ability to serve as a cytokinin-responsive environmental sensor.	Aspartic Acid	37-40	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	149-153
11230563-4	2001	Taking advantage of this AHK4-dependent His--&gt;Asp phosphorelay system in E. coli, a phosphorelay interaction between the Arabidopsis His-kinase and histidine-containing phosphotransmitters (AHPs) was also demonstrated for the first time.	Aspartic Acid	49-52	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	25-29
11060297-6	2001	The metabolism of [5-(3)H]glucose and the glucose-stimulated insulin secretion from rat insulinoma cells, INS-1, were effectively inhibited by 500 microm or 1 mm propyl gallate and to a lesser extent by 5 mm aminooxyacetate, a potent malate-aspartate shuttle inhibitor.	Aspartic Acid	241-250	insulin 1	Rattus norvegicus	106-111
11053423-3	2001	Main interaction sites are centered around Asp(79), Asp(76), Asp(72), and Asp(39) of Adx and around Arg(211), Arg(240), Arg(244), and Lys(27) of AR, respectively.	Aspartic Acid	43-46	ferredoxin reductase	Homo sapiens	145-147
11060302-5	2001	Interestingly, not only aspartic acid but also asparagine were identified as products of NIT4-catalyzed Ala(CN) hydrolysis.	Aspartic Acid	24-37	nitrilase 4	Arabidopsis thaliana	89-93
11060302-9	2001	The NIT4 homologs of N. tabacum were found to catalyze the same reactions and protein extracts of A. thaliana, N. tabacum and Lupinus angustifolius also converted Ala(CN) to Asp and Asn in vitro.	Aspartic Acid	174-177	nitrilase 4	Arabidopsis thaliana	4-8
11067847-11	2001	The data collectively indicate that His-12 and Asp-258, but not Cys-183 or Cys-281, are required for the PTP activity of PAcP.	Aspartic Acid	47-50	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	105-108
11067847-11	2001	The data collectively indicate that His-12 and Asp-258, but not Cys-183 or Cys-281, are required for the PTP activity of PAcP.	Aspartic Acid	47-50	acid phosphatase 3	Homo sapiens	121-125
11053423-3	2001	Main interaction sites are centered around Asp(79), Asp(76), Asp(72), and Asp(39) of Adx and around Arg(211), Arg(240), Arg(244), and Lys(27) of AR, respectively.	Aspartic Acid	52-55	ferredoxin 1	Homo sapiens	85-88
11053423-3	2001	Main interaction sites are centered around Asp(79), Asp(76), Asp(72), and Asp(39) of Adx and around Arg(211), Arg(240), Arg(244), and Lys(27) of AR, respectively.	Aspartic Acid	52-55	ferredoxin 1	Homo sapiens	85-88
11053423-3	2001	Main interaction sites are centered around Asp(79), Asp(76), Asp(72), and Asp(39) of Adx and around Arg(211), Arg(240), Arg(244), and Lys(27) of AR, respectively.	Aspartic Acid	52-55	ferredoxin 1	Homo sapiens	85-88
11053423-4	2001	In particular, the region around Asp(39) defines a new protein interaction site for Adx, similar to those found in plant and bacterial ferredoxins.	Aspartic Acid	33-36	ferredoxin 1	Homo sapiens	84-87
11035011-3	2001	Using point mutants of the conserved negatively charged amino acids present in the putative pore, we have identified a single aspartate residue that determines Ca(2+) permeation of ECaC and modulation by extracellular Mg(2+).	Aspartic Acid	126-135	transient receptor potential cation channel subfamily V member 5	Oryctolagus cuniculus	181-185
11139392-8	2001	The deduced amino acid sequence of rat DPP II shared high similarity with quiescent-cell proline dipeptidase (78% identity) and prolyl carboxypeptidase (38% identity) and bore the putative catalytic triad (Ser, Asp, His) conserved in serine peptidase families.	Aspartic Acid	211-214	dipeptidylpeptidase 7	Rattus norvegicus	39-45
11013258-3	2001	[Asn(3)] VIP and [Gln(3)] VIP had lower affinities than VIP for VPAC(1) receptors but higher affinities for the mutant receptors; the two basic amino acids facilitated the introduction of the negatively charged aspartate inside the transmembrane domain.	Aspartic Acid	211-220	vasoactive intestinal peptide	Homo sapiens	9-12
11013258-3	2001	[Asn(3)] VIP and [Gln(3)] VIP had lower affinities than VIP for VPAC(1) receptors but higher affinities for the mutant receptors; the two basic amino acids facilitated the introduction of the negatively charged aspartate inside the transmembrane domain.	Aspartic Acid	211-220	vasoactive intestinal peptide	Homo sapiens	26-29
11013258-3	2001	[Asn(3)] VIP and [Gln(3)] VIP had lower affinities than VIP for VPAC(1) receptors but higher affinities for the mutant receptors; the two basic amino acids facilitated the introduction of the negatively charged aspartate inside the transmembrane domain.	Aspartic Acid	211-220	vasoactive intestinal peptide	Homo sapiens	26-29
11152972-7	2001	Mutations of K-ras, analyzed by single-strand conformation polymorphism and sequencing, were, in codon 12, wild type GGT (glycine), to GAT (aspartic acid); to GTT (valine); and to CGT (arginine); and in codon 61, wild-type CAA (glutamine), to CGA (arginine).	Aspartic Acid	140-153	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	13-18
11212871-1	2001	The excitatory amino acids (EAAs), glutamate and aspartate, acting predominantly on N-methyl-D-aspartate (NMDA) receptor, have been shown to be involved in the central regulation of the secretion of several anterior pituitary hormones including prolactin (PRL), whereas ketamine hydrochloride (KH), a widely used anesthetic, has been reported to antagonize a variety of NMDA receptor mediated actions of these EAAs.	Aspartic Acid	49-58	prolactin	Macaca mulatta	245-254
11212871-1	2001	The excitatory amino acids (EAAs), glutamate and aspartate, acting predominantly on N-methyl-D-aspartate (NMDA) receptor, have been shown to be involved in the central regulation of the secretion of several anterior pituitary hormones including prolactin (PRL), whereas ketamine hydrochloride (KH), a widely used anesthetic, has been reported to antagonize a variety of NMDA receptor mediated actions of these EAAs.	Aspartic Acid	49-58	prolactin	Macaca mulatta	256-259
11341914-1	2001	Fungal homoserine dehydrogenase (HSD) is required for the biosynthesis of threonine, isoleucine and methionine from aspartic acid, and is a target for antifungal agents.	Aspartic Acid	116-129	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	7-31
11341914-1	2001	Fungal homoserine dehydrogenase (HSD) is required for the biosynthesis of threonine, isoleucine and methionine from aspartic acid, and is a target for antifungal agents.	Aspartic Acid	116-129	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	33-36
11460528-6	2001	For example the mutation, A alpha 20 Val--&gt;Asp, makes the protein a substrate for furin, which removes the first 19 residues of the A alpha chain as the mature molecule transits the trans golgi complex.	Aspartic Acid	46-49	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
11042198-6	2001	Based on this model, two residues (Lys-183 and Asp-217) in the regulatory IDH1 subunit were predicted to be important in the catalytic site of IDH2.	Aspartic Acid	47-50	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	74-78
11042198-6	2001	Based on this model, two residues (Lys-183 and Asp-217) in the regulatory IDH1 subunit were predicted to be important in the catalytic site of IDH2.	Aspartic Acid	47-50	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	143-147
11042198-8	2001	Also based on this model, the two analogous residues (Lys-189 and Asp-222) of the catalytic IDH2 subunit were predicted to contribute to the regulatory site of IDH1.	Aspartic Acid	66-69	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	92-96
11042198-8	2001	Also based on this model, the two analogous residues (Lys-189 and Asp-222) of the catalytic IDH2 subunit were predicted to contribute to the regulatory site of IDH1.	Aspartic Acid	66-69	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	160-164
11732605-7	2001	Contacts between MetRS and other proteins could be mediated not only by noncatalytic peptides but also by structural elements present in the catalytic core, e.g. Arg-Gly-Asp (RGD) motifs.	Aspartic Acid	170-173	methionyl-tRNA synthetase 1	Homo sapiens	17-22
11257802-0	2001	Inhibition of platelet aggregation of a mutant proinsulin molecule engineered by introduction of a native Arg-Gly-Asp sequence.	Aspartic Acid	114-117	insulin	Homo sapiens	47-57
11696986-9	2001	Poly(Asp) was able to displace a maximum of 100% of Poly(Glu), 99% of Poly(Asp), 95% of OPN and 89% of BSP.	Aspartic Acid	5-9	secreted phosphoprotein 1	Homo sapiens	88-91
11257802-2	2001	The constructed Arg-Gly-Asp (RGD)-proinsulin gene was cloned into a temperature-inducible vector pBV220 and expressed in Escherichia coli.	Aspartic Acid	24-27	insulin	Homo sapiens	34-44
11696986-2	2001	The HA-binding properties of these proteins have been attributed to glutamic acid-rich sequences in BSP and aspartic acid-rich sequences in OPN.	Aspartic Acid	108-121	secreted phosphoprotein 1	Homo sapiens	140-143
11137709-13	2001	In conclusion, the side chains of Asp(4), Phe(6), Val(7), Leu(9), and Met(10) are structurally important features of NKA(4-10) for agonist activity, and changes in amino acid chirality are detrimental to binding affinity and functional activity.	Aspartic Acid	34-37	tachykinin precursor 1	Homo sapiens	117-120
11696986-9	2001	Poly(Asp) was able to displace a maximum of 100% of Poly(Glu), 99% of Poly(Asp), 95% of OPN and 89% of BSP.	Aspartic Acid	5-9	integrin binding sialoprotein	Homo sapiens	103-106
11696986-7	2001	To investigate the role of glutamic acid-rich and aspartic acid-rich sequences in the binding to HA of BSP and OPN, respectively, competitive binding studies with Poly(Glu) and Poly(Asp) were performed.	Aspartic Acid	50-63	integrin binding sialoprotein	Homo sapiens	103-106
11696986-9	2001	Poly(Asp) was able to displace a maximum of 100% of Poly(Glu), 99% of Poly(Asp), 95% of OPN and 89% of BSP.	Aspartic Acid	5-8	secreted phosphoprotein 1	Homo sapiens	88-91
11696986-9	2001	Poly(Asp) was able to displace a maximum of 100% of Poly(Glu), 99% of Poly(Asp), 95% of OPN and 89% of BSP.	Aspartic Acid	5-8	integrin binding sialoprotein	Homo sapiens	103-106
11496831-5	2001	Molecular mechanics calculations showed that the preferred tautomeric form of these compounds is of the type ArSO2N=C(NH2) NH-CN, probably allowing for the formation of favorable interaction between this new anchoring group and the active site amino acid residue Asp 189, critical for substrate/inhibitor binding to this type of serine protease.	Aspartic Acid	263-266	coagulation factor II, thrombin	Homo sapiens	329-344
11136715-10	2001	The Gly--&gt;Asp mutation within a highly conserved sequence highlights its importance for GLUT1 function.	Aspartic Acid	13-16	solute carrier family 2 member 1	Homo sapiens	91-96
16232942-4	2001	In addition, the rate of induction of rho- was markedly reduced by overexpression of LAS17 when serine, tyrosine, and aspartic acid were used as N sources and the yeast was cultured at 35 degrees C, while rho- strains in control cultures were induced at a high frequency.	Aspartic Acid	118-131	actin-binding protein LAS17	Saccharomyces cerevisiae S288C	85-90
11169446-6	2001	In Fab S20, the Arg(30) and Asp(31) somatically replaced residues in HCDR1 improved antigen binding.	Aspartic Acid	28-31	FA complementation group B	Homo sapiens	3-6
11169446-9	2001	Molecular modeling of S20 HCDR1 suggests that Arg(30) and Asp(31) are the main interaction sites for gp120, increasing antibody affinity and promoting the enhanced neutralization ability of S20.	Aspartic Acid	58-61	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	101-106
11769310-11	2001	These results suggest that the mossy fiber-CA3 system is vulnerable to aspartate isomerization and that the PIMT-mediated repair system is essential for maintenance of normal functions of the hippocampus.	Aspartic Acid	71-80	carbonic anhydrase 3	Mus musculus	43-46
11697045-7	2001	AAT-2 uses 2-amino-4-methoxy-4-oxobutanoic acid at a similar rate as L-aspartate but AAT-1 uses this substrate at a slower rate.	Aspartic Acid	69-80	AAT2	Homo sapiens	0-5
11697047-3	2001	Using human glycosylasparaginase from human amniotic fluid, L-aspartic acid and four of its analogues, where the alpha-amino group was substituted with a chloro, bromo, methyl or hydrogen, were competitive inhibitors having Ki values between 0.6-7.7 mM.	Aspartic Acid	60-75	aspartylglucosaminidase	Homo sapiens	12-32
11136855-5	2001	Mutations of the GYGD motif in the rat drk1 (Kv2.1) K+ channel showed that the tyrosine (Y) position was important for K+ selectivity and single channel conductance, whereas the aspartate (D) position was a critical determinant of open state stability.	Aspartic Acid	178-187	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	39-43
11136855-5	2001	Mutations of the GYGD motif in the rat drk1 (Kv2.1) K+ channel showed that the tyrosine (Y) position was important for K+ selectivity and single channel conductance, whereas the aspartate (D) position was a critical determinant of open state stability.	Aspartic Acid	178-187	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	45-50
11210664-3	2001	Structural variations of the L-aspartic acid substructure of (S)-N-3-phenoxycinnamoylaspartic acid dimethyl ester which shows a selective antiproliferative activity against THP-1 tumor cells, demonstrated that the L-aspartic acid moiety is absolutely mandatory for antiproliferative activity as well as for selectivity.	Aspartic Acid	29-44	GLI family zinc finger 2	Homo sapiens	173-178
11141191-7	2001	We also discovered a "hidden homology" in the TIM barrel, an invariant Gly located upstream in the sequence before the conserved Asp in beta-strand 3.	Aspartic Acid	129-132	Rho guanine nucleotide exchange factor 5	Homo sapiens	46-49
11964518-1	2001	OBJECTIVE: To analyze the 24-hour changes in thymic and serum concentration of growth hormone (GH) and adrenocorticotropin (ACTH) and their correlation with thymic concentrations of glutamate, aspartate, taurine and GABA in young and old rats during the acute phase of adjuvant"s arthritis.	Aspartic Acid	193-202	gonadotropin releasing hormone receptor	Rattus norvegicus	79-93
11964518-1	2001	OBJECTIVE: To analyze the 24-hour changes in thymic and serum concentration of growth hormone (GH) and adrenocorticotropin (ACTH) and their correlation with thymic concentrations of glutamate, aspartate, taurine and GABA in young and old rats during the acute phase of adjuvant"s arthritis.	Aspartic Acid	193-202	gonadotropin releasing hormone receptor	Rattus norvegicus	95-97
11154351-9	2001	A topological model suggests that aspartate-138 in SynNhaP is conserved in NhaP, SOS1, and AtNHX1 and is involved in the exchange activity.	Aspartic Acid	34-43	Na+/H+ exchanger 1	Arabidopsis thaliana	91-97
11158442-9	2001	Because several factors carrying the TCP domain have been implicated in the regulation of growth and development in lateral organs, the binding of TCP10 to this subset of AHPs suggests a possible linkage between the His-to-Asp phosphorelay systems and plant growth regulation.	Aspartic Acid	223-226	TCP domain protein 10	Arabidopsis thaliana	147-152
11210664-3	2001	Structural variations of the L-aspartic acid substructure of (S)-N-3-phenoxycinnamoylaspartic acid dimethyl ester which shows a selective antiproliferative activity against THP-1 tumor cells, demonstrated that the L-aspartic acid moiety is absolutely mandatory for antiproliferative activity as well as for selectivity.	Aspartic Acid	214-229	GLI family zinc finger 2	Homo sapiens	173-178
11123910-1	2000	One of the putative proton-transfer pathways leading from solution toward the binuclear center in many cytochrome c oxidases is the D-pathway, so-called because it starts with a highly conserved aspartate [D(I-132)] residue.	Aspartic Acid	195-204	cytochrome c, somatic	Homo sapiens	103-115
11008488-5	2001	Site-directed mutagenesis of rat SQS has identified conserved Tyr, Phe, and Asp residues that are essential for function.	Aspartic Acid	76-79	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	33-36
12040407-0	2001	Asp(126), Asp(130) and Asp(134) are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC.	Aspartic Acid	0-3	interleukin 18	Homo sapiens	56-61
12040407-0	2001	Asp(126), Asp(130) and Asp(134) are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC.	Aspartic Acid	0-3	interferon gamma	Homo sapiens	72-81
12040407-0	2001	Asp(126), Asp(130) and Asp(134) are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC.	Aspartic Acid	10-13	interleukin 18	Homo sapiens	56-61
12040407-0	2001	Asp(126), Asp(130) and Asp(134) are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC.	Aspartic Acid	10-13	interleukin 18	Homo sapiens	56-61
12040407-1	2001	To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys.	Aspartic Acid	127-130	interleukin 18	Homo sapiens	58-72
12040407-1	2001	To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys.	Aspartic Acid	127-130	interleukin 18	Homo sapiens	74-79
12040407-1	2001	To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys.	Aspartic Acid	137-140	interleukin 18	Homo sapiens	74-79
12040407-1	2001	To identify the amino acid residues which are critical to interleukin 18 (IL-18) function, three highly-conserved amino acids (Asp(126), Asp(130) and Asp(134)) were mutated to Asn, Lys and Lys.	Aspartic Acid	137-140	interleukin 18	Homo sapiens	74-79
11123927-1	2000	The carboxyl-specific amino acid modification reagent, Woodward"s reagent K (WK), was utilized to characterize carboxyl residues (Asp and Glu) in the active site of human phenol sulfotransferase (SULT1A1).	Aspartic Acid	130-133	sulfotransferase family 1A member 1	Homo sapiens	196-203
11111077-4	2000	Site-directed mutagenesis has identified conserved Asp, Tyr, and Phe residues that are essential for SQS activity.	Aspartic Acid	51-54	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	101-104
11106382-4	2000	Our results showed that the counterion is the glutamic acid at position 181, at which almost all the pigments in the rhodopsin family, including vertebrate and invertebrate rhodopsins, have a glutamic or aspartic acid.	Aspartic Acid	204-217	rhodopsin	Bos taurus	117-126
10973972-4	2000	LIMPII and GLUT4 display negatively (Asp(470)/Glu(471)) and positively (Arg(484)/Arg(485)) charged residues, respectively, at positions -4 and -5 upstream from the critical Leu residue.	Aspartic Acid	37-40	scavenger receptor class B member 2	Homo sapiens	0-6
10973972-4	2000	LIMPII and GLUT4 display negatively (Asp(470)/Glu(471)) and positively (Arg(484)/Arg(485)) charged residues, respectively, at positions -4 and -5 upstream from the critical Leu residue.	Aspartic Acid	37-40	solute carrier family 2 member 4	Homo sapiens	11-16
10967097-0	2000	The Na+/Ca2+ exchanger NCX1 has oppositely oriented reentrant loop domains that contain conserved aspartic acids whose mutation alters its apparent Ca2+ affinity.	Aspartic Acid	98-112	solute carrier family 8 member A1	Homo sapiens	23-27
10960471-15	2000	), indicate that the most likely positioning of fMLF in the binding pocket of FPR is approximately parallel to the fifth transmembrane helix with the formamide group of fMLF hydrogen-bonded to both Asp-106 and Arg-201, the leucine side chain pointing toward the second transmembrane region, and the COOH-terminal carboxyl group of fMLF ion-paired with Arg-205.	Aspartic Acid	198-201	formyl peptide receptor 1	Homo sapiens	78-81
10995773-2	2000	To investigate the mechanism of ion transport by P-type ATPases we have mutagenized Asp(684), a residue in transmembrane segment M6 of AHA2 that is conserved in Ca(2+)-, Na(+)/K(+)-, H(+)/K(+)-, and H(+)-ATPases and which coordinates Ca(2+) ions in the SERCA1 Ca(2+)-ATPase.	Aspartic Acid	84-87	H[+]-ATPase 2	Arabidopsis thaliana	135-139
10995773-3	2000	We describe the expression, purification, and biochemical analysis of the Asp(684) --&gt; Asn mutant, and provide evidence that Asp(684) in the plasma membrane H(+)-ATPase is required for any coupling between ATP hydrolysis, enzyme conformational changes, and H(+)-transport.	Aspartic Acid	74-77	plasma membrane H+-ATPase	Arabidopsis thaliana	144-171
10995773-3	2000	We describe the expression, purification, and biochemical analysis of the Asp(684) --&gt; Asn mutant, and provide evidence that Asp(684) in the plasma membrane H(+)-ATPase is required for any coupling between ATP hydrolysis, enzyme conformational changes, and H(+)-transport.	Aspartic Acid	128-131	plasma membrane H+-ATPase	Arabidopsis thaliana	144-171
10995746-8	2000	N-Glycanase cleaves the new oligosaccharide from Q333N fXa leaving aspartic acid.	Aspartic Acid	67-80	coagulation factor X	Homo sapiens	55-58
11113390-1	2000	Mammalian bone sialoprotein (BSP) is a mineralized tissue-specific protein containing an RGD (arginine-glycine-aspartic acid) cell-attachment sequence and two distinct glutamic acid (glu)-rich regions, with each containing one contiguous glu sequence.	Aspartic Acid	111-124	integrin binding sialoprotein	Homo sapiens	10-27
11144701-7	2000	DATA SYNTHESIS: Insulin aspart, the second Food and Drug Administration-approved rapid-acting insulin analog, is produced by recombinant technology that replaces the proline at position 28 on the B chain of insulin with negatively charged aspartic acid.	Aspartic Acid	239-252	insulin	Homo sapiens	16-23
11113390-1	2000	Mammalian bone sialoprotein (BSP) is a mineralized tissue-specific protein containing an RGD (arginine-glycine-aspartic acid) cell-attachment sequence and two distinct glutamic acid (glu)-rich regions, with each containing one contiguous glu sequence.	Aspartic Acid	111-124	integrin binding sialoprotein	Homo sapiens	29-32
11209755-6	2000	The architecture of the substrate binding site of granzyme B appears to be designed to accommodate and cleave hexapeptides such as the sequence Ile-Glu-Thr-Asp-/Ser-Gly present in the activation site of pro-caspase-3, a proven physiological substrate of granzyme B.	Aspartic Acid	156-159	granzyme B	Homo sapiens	50-60
11082192-5	2000	Transfer of exponentially growing cells of the pyc2 mutant from an aspartate or a glutamate medium to an ammonium medium caused a fivefold increase in PYC1 mRNA in less than 30 min, whereas in the inverse experiment, PYC1 transcripts returned within 30 min to the low levels found in aspartate/glutamate medium.	Aspartic Acid	67-76	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	47-51
11209755-6	2000	The architecture of the substrate binding site of granzyme B appears to be designed to accommodate and cleave hexapeptides such as the sequence Ile-Glu-Thr-Asp-/Ser-Gly present in the activation site of pro-caspase-3, a proven physiological substrate of granzyme B.	Aspartic Acid	156-159	caspase 3	Homo sapiens	203-216
11209755-6	2000	The architecture of the substrate binding site of granzyme B appears to be designed to accommodate and cleave hexapeptides such as the sequence Ile-Glu-Thr-Asp-/Ser-Gly present in the activation site of pro-caspase-3, a proven physiological substrate of granzyme B.	Aspartic Acid	156-159	granzyme B	Homo sapiens	254-264
11082192-5	2000	Transfer of exponentially growing cells of the pyc2 mutant from an aspartate or a glutamate medium to an ammonium medium caused a fivefold increase in PYC1 mRNA in less than 30 min, whereas in the inverse experiment, PYC1 transcripts returned within 30 min to the low levels found in aspartate/glutamate medium.	Aspartic Acid	67-76	pyruvate carboxylase 1	Saccharomyces cerevisiae S288C	151-155
11082192-5	2000	Transfer of exponentially growing cells of the pyc2 mutant from an aspartate or a glutamate medium to an ammonium medium caused a fivefold increase in PYC1 mRNA in less than 30 min, whereas in the inverse experiment, PYC1 transcripts returned within 30 min to the low levels found in aspartate/glutamate medium.	Aspartic Acid	284-293	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	47-51
11069235-4	2000	Tat proteins with inactivating substitutions in the arginine-glycine-aspartic acid or basic domain were still active in inducing PMNL migration, whereas Tat peptides mapped the migration and Ca(2+) mobilization activity to a cysteine-rich core domain, previously described as a Tat "chemokine-like" region (peptide CysL(24-51)).	Aspartic Acid	69-82	tyrosine aminotransferase	Homo sapiens	0-3
11099312-3	2000	All three TCR exhibited N-nucleotide-determined Arg-Asp motifs in their CDR3-ss sequences.	Aspartic Acid	52-55	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	10-13
11099312-3	2000	All three TCR exhibited N-nucleotide-determined Arg-Asp motifs in their CDR3-ss sequences.	Aspartic Acid	52-55	CDR3	Homo sapiens	72-76
11099312-8	2000	Hence, in these two TCR the Arg-Asp motif is clearly involved in contacting Ni-MHC complexes, and close cooperation between alpha and ss chain is required.	Aspartic Acid	32-35	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	20-23
11099312-8	2000	Hence, in these two TCR the Arg-Asp motif is clearly involved in contacting Ni-MHC complexes, and close cooperation between alpha and ss chain is required.	Aspartic Acid	32-35	major histocompatibility complex, class I, C	Homo sapiens	79-82
11099312-9	2000	In contrast, the third TCR retained Ni reactivity upon mutation of alpha chain position 51 or of its ss chain Arg-Asp motif, which rather affected the pattern of DR cross-restriction.	Aspartic Acid	114-117	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	23-26
10964919-4	2000	Recently, we have identified a site in the C-type lectin-like domain of tetranectin, involving Lys-148, Glu-150, and Asp-165, which mediates calcium-sensitive binding to plasminogen kringle 4.	Aspartic Acid	117-120	C-type lectin domain family 3 member B	Homo sapiens	72-83
10967122-8	2000	Herein, we show that the function of the highly conserved Asp can be mimicked by poly-Ala substitutions in the LHR and thyrotropin receptor.	Aspartic Acid	58-61	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	111-114
10967122-8	2000	Herein, we show that the function of the highly conserved Asp can be mimicked by poly-Ala substitutions in the LHR and thyrotropin receptor.	Aspartic Acid	58-61	thyroid stimulating hormone receptor	Homo sapiens	119-139
10967122-9	2000	CD and NMR studies of peptides derived from the juxtamembrane portion of the LHR confirmed the helix extension by the poly-Ala substitution and provided further evidence for an involvement of Asp in a helix-capping structure.	Aspartic Acid	192-195	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	77-80
11087420-8	2000	We also analyzed the effects of mutating Asp-143, a residue in the alphaB helix of alpha1-syntrophin that forms a tertiary contact with the nNOS PDZ domain.	Aspartic Acid	41-44	syntrophin alpha 1	Homo sapiens	83-100
11090274-0	2000	An aspartic acid residue in TPR-1, a specific region of protein-priming DNA polymerases, is required for the functional interaction with primer terminal protein.	Aspartic Acid	3-16	tetratricopeptide repeat domain 1	Homo sapiens	28-33
11101902-6	2000	Based on our findings, we conclude that DEP interacts with regulators upstream of Dvl via a strong electric dipole on the molecule"s surface created by Lys 434, Asp 445 and Asp 448; the electric dipole and the putative membrane binding site are at two different locations.	Aspartic Acid	161-164	zinc finger, DHHC domain containing 21	Mus musculus	40-43
11101902-6	2000	Based on our findings, we conclude that DEP interacts with regulators upstream of Dvl via a strong electric dipole on the molecule"s surface created by Lys 434, Asp 445 and Asp 448; the electric dipole and the putative membrane binding site are at two different locations.	Aspartic Acid	161-164	dishevelled segment polarity protein 1	Mus musculus	82-85
11101902-6	2000	Based on our findings, we conclude that DEP interacts with regulators upstream of Dvl via a strong electric dipole on the molecule"s surface created by Lys 434, Asp 445 and Asp 448; the electric dipole and the putative membrane binding site are at two different locations.	Aspartic Acid	173-176	zinc finger, DHHC domain containing 21	Mus musculus	40-43
11101902-6	2000	Based on our findings, we conclude that DEP interacts with regulators upstream of Dvl via a strong electric dipole on the molecule"s surface created by Lys 434, Asp 445 and Asp 448; the electric dipole and the putative membrane binding site are at two different locations.	Aspartic Acid	173-176	dishevelled segment polarity protein 1	Mus musculus	82-85
11114265-3	2000	Dominant negative mutations of the critical transmembrane aspartates in PS1 or full deletion of PS1 did not alter the maturation of APP in the secretory pathway.	Aspartic Acid	58-68	presenilin 1	Homo sapiens	72-75
11087420-8	2000	We also analyzed the effects of mutating Asp-143, a residue in the alphaB helix of alpha1-syntrophin that forms a tertiary contact with the nNOS PDZ domain.	Aspartic Acid	41-44	nitric oxide synthase 1	Homo sapiens	140-144
10893229-5	2000	A transcriptionally active form of IRF-7 was also generated by substitution of Ser-477 and Ser-479 residues with the phosphomimetic Asp.	Aspartic Acid	132-135	interferon regulatory factor 7	Homo sapiens	35-40
11092760-8	2000	This MNK-dependent activation of tyrosinase was impaired by the chelation of copper in the medium of cells and after mutation of the invariant phosphorylation site at aspartic acid residue 1044 of MNK.	Aspartic Acid	167-180	ATPase copper transporting alpha	Homo sapiens	5-8
11092760-8	2000	This MNK-dependent activation of tyrosinase was impaired by the chelation of copper in the medium of cells and after mutation of the invariant phosphorylation site at aspartic acid residue 1044 of MNK.	Aspartic Acid	167-180	tyrosinase	Homo sapiens	33-43
11092760-8	2000	This MNK-dependent activation of tyrosinase was impaired by the chelation of copper in the medium of cells and after mutation of the invariant phosphorylation site at aspartic acid residue 1044 of MNK.	Aspartic Acid	167-180	ATPase copper transporting alpha	Homo sapiens	197-200
11062062-4	2000	Equilibrium (125)I-EGF binding studies demonstrate that the conversion of Tyr-992 into glutamate induces a 4-fold decrease in the EGFr apparent low-affinity dissociation constant, whereas the mutation of two acidic residues, Asp-988 and Glu-991, or the conversion of Tyr-992 into phenylalanine does not alter EGFr affinity.	Aspartic Acid	225-228	epidermal growth factor receptor	Cricetulus griseus	130-134
11063586-7	2000	The NQO8 subunit of P. denitrificans complex I is a homologue of ND1, and within it three conserved Glu residues that could bind DCCD, E158, E212, and E247, were changed to either Asp or Gln and in the case of E212 also to Val.	Aspartic Acid	180-183	NADH dehydrogenase subunit 1	Bos taurus	65-68
10938284-5	2000	In addition, human SYT IV has a characteristic serine for aspartate substitution within the first C2 domain that is conserved among Drosophila, Caenorhabditis elegans, mouse, and rat SYT IV sequences.	Aspartic Acid	58-67	synaptotagmin 4	Homo sapiens	19-25
10938284-5	2000	In addition, human SYT IV has a characteristic serine for aspartate substitution within the first C2 domain that is conserved among Drosophila, Caenorhabditis elegans, mouse, and rat SYT IV sequences.	Aspartic Acid	58-67	synaptotagmin 4	Rattus norvegicus	183-189
11078511-7	2000	Mutation of an Asp-252 of SMN abolished cleavage of SMN and increased the antiapoptotic function of full-length SMN in neurons.	Aspartic Acid	15-18	survival of motor neuron 1, telomeric	Homo sapiens	26-29
11078511-7	2000	Mutation of an Asp-252 of SMN abolished cleavage of SMN and increased the antiapoptotic function of full-length SMN in neurons.	Aspartic Acid	15-18	survival of motor neuron 1, telomeric	Homo sapiens	52-55
11078511-7	2000	Mutation of an Asp-252 of SMN abolished cleavage of SMN and increased the antiapoptotic function of full-length SMN in neurons.	Aspartic Acid	15-18	survival of motor neuron 1, telomeric	Homo sapiens	52-55
11062068-6	2000	The point mutation Asp-316--&gt;Asn in the C-terminus of p38, analogous to the ERK2 (extracellular-signal-regulated kinase 2) sevenmaker mutation, dramatically decreases its binding to MKP-1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase.	Aspartic Acid	19-22	mitogen-activated protein kinase 14	Homo sapiens	57-60
11062068-6	2000	The point mutation Asp-316--&gt;Asn in the C-terminus of p38, analogous to the ERK2 (extracellular-signal-regulated kinase 2) sevenmaker mutation, dramatically decreases its binding to MKP-1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase.	Aspartic Acid	19-22	mitogen-activated protein kinase 1	Homo sapiens	79-83
11062068-6	2000	The point mutation Asp-316--&gt;Asn in the C-terminus of p38, analogous to the ERK2 (extracellular-signal-regulated kinase 2) sevenmaker mutation, dramatically decreases its binding to MKP-1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase.	Aspartic Acid	19-22	mitogen-activated protein kinase 1	Homo sapiens	85-124
11062068-6	2000	The point mutation Asp-316--&gt;Asn in the C-terminus of p38, analogous to the ERK2 (extracellular-signal-regulated kinase 2) sevenmaker mutation, dramatically decreases its binding to MKP-1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase.	Aspartic Acid	19-22	dual specificity phosphatase 1	Homo sapiens	185-190
10946001-7	2000	Residues Glu(227), Asp(252), and Glu(281) dictate the binding orientation of the terminal Gal-2 moiety.	Aspartic Acid	19-22	galectin 2	Homo sapiens	90-95
10913436-5	2000	Several lines of evidence show that La protein is cleaved by caspase-3 or closely related proteases at Asp-374 in the COOH terminus.	Aspartic Acid	103-106	caspase 3	Homo sapiens	61-70
11029509-7	2000	Tumor B18 exhibited two novel mutations in the p53 gene, ATGright curved arrow GTG (Metright curved arrow Val) at codon 237 and AATright curved arrow GAT (Asnright curved arrow Asp) at codon 263.	Aspartic Acid	177-180	NADH:ubiquinone oxidoreductase subunit B7	Homo sapiens	6-9
11186260-0	2000	Hb Nikaia [alpha20(B1)His-Asp]: a new variant of the alpha2 gene.	Aspartic Acid	26-29	glycoprotein hormone subunit alpha 2	Homo sapiens	11-17
11029509-7	2000	Tumor B18 exhibited two novel mutations in the p53 gene, ATGright curved arrow GTG (Metright curved arrow Val) at codon 237 and AATright curved arrow GAT (Asnright curved arrow Asp) at codon 263.	Aspartic Acid	177-180	tumor protein p53	Homo sapiens	47-50
11035780-8	2000	Two other mutations, replacing the aspartic acid residues at either positions 100 or 136 with alanine, also increase IRT1 metal selectivity by eliminating transport of both iron and manganese.	Aspartic Acid	35-48	iron-regulated transporter 1	Arabidopsis thaliana	117-121
11096344-6	2000	Individuals carrying the HFE282Tyr allele (homo- and heterozygotes) in combination with homozygosity for the TFR Ser allele showed an increased risk for HCC (OR = 3.5; 95% confidence interval, CI = 1.3-9.3), which was further increased in HFE Tyr homozygotes and compound (Tyr/Asp) heterozygotes in combination with TFR 142Ser homozygosity (OR = 17.2; 95% CI = 1.8-168.9).	Aspartic Acid	277-280	transferrin receptor	Homo sapiens	109-112
11096344-6	2000	Individuals carrying the HFE282Tyr allele (homo- and heterozygotes) in combination with homozygosity for the TFR Ser allele showed an increased risk for HCC (OR = 3.5; 95% confidence interval, CI = 1.3-9.3), which was further increased in HFE Tyr homozygotes and compound (Tyr/Asp) heterozygotes in combination with TFR 142Ser homozygosity (OR = 17.2; 95% CI = 1.8-168.9).	Aspartic Acid	277-280	homeostatic iron regulator	Homo sapiens	25-28
11046064-6	2000	CCR2B was found to be sulfated at Tyr(26); this sulfation was abolished by the substitution of Tyr with Ala and severely reduced by substitution of Asp(25), a part of the consensus sulfation site.	Aspartic Acid	148-151	C-C motif chemokine receptor 2	Homo sapiens	0-5
11056541-1	2000	Endoproteolysis of beta-amyloid precursor protein (betaAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1 and PS2).	Aspartic Acid	89-98	amyloid beta precursor protein	Homo sapiens	19-49
11056541-1	2000	Endoproteolysis of beta-amyloid precursor protein (betaAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1 and PS2).	Aspartic Acid	89-98	amyloid beta precursor protein	Homo sapiens	51-58
11056541-1	2000	Endoproteolysis of beta-amyloid precursor protein (betaAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1 and PS2).	Aspartic Acid	89-98	presenilin 1	Homo sapiens	132-135
11056541-1	2000	Endoproteolysis of beta-amyloid precursor protein (betaAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1 and PS2).	Aspartic Acid	89-98	taste 2 receptor member 64 pseudogene	Homo sapiens	140-143
11152138-7	2000	The small amount of the L-isoAsp isomer, representing only part of the D-isoAsp isomer, and the relatively large amounts of the L-Asp and D-Asp isomers argues for an effective action of PIMT present in cardiac tissue.	Aspartic Acid	128-133	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	186-190
11035786-8	2000	Consistent with this, mutating each of the threonines individually to aspartate in separate mutants restored the PKC sensitivity of Ca(v)1.2, indicating that a change in net charge by phosphorylation of both sites is responsible for inhibition.	Aspartic Acid	70-79	proline rich transmembrane protein 2	Homo sapiens	113-116
11035786-8	2000	Consistent with this, mutating each of the threonines individually to aspartate in separate mutants restored the PKC sensitivity of Ca(v)1.2, indicating that a change in net charge by phosphorylation of both sites is responsible for inhibition.	Aspartic Acid	70-79	immunoglobulin lambda variable 2-8	Homo sapiens	132-140
10913437-6	2000	In contrast to the site-directed mutagenesis study, the crystal structures of human and rat AdoHcyase recently determined have shown that the carboxyl group of Asp-244 points in a direction opposite to the bound NAD molecule and does not participate in any hydrogen bonds with the NAD molecule.	Aspartic Acid	160-163	adenosylhomocysteinase	Rattus norvegicus	92-101
10903320-2	2000	A topological reporter construct, encoding an internal 53-amino acid peptide of invertase (Suc2p) containing three Asp-X-Ser/Thr glycosylation sites, was inserted in-frame into the hydrophilic NH(2)- and COOH-terminal domains and each of the 11 hydrophilic loops that separate the 12 hydrophobic segments of Gap1p.	Aspartic Acid	115-118	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	91-96
10884387-6	2000	Since the PHO2 Asp-230 mutant mimics Ser-230-phosphorylated PHO2, we postulate that only phosphorylated PHO2 protein could activate the transcription of PHO5 gene.	Aspartic Acid	15-18	Pho2p	Saccharomyces cerevisiae S288C	10-14
10884387-6	2000	Since the PHO2 Asp-230 mutant mimics Ser-230-phosphorylated PHO2, we postulate that only phosphorylated PHO2 protein could activate the transcription of PHO5 gene.	Aspartic Acid	15-18	Pho2p	Saccharomyces cerevisiae S288C	60-64
10884387-6	2000	Since the PHO2 Asp-230 mutant mimics Ser-230-phosphorylated PHO2, we postulate that only phosphorylated PHO2 protein could activate the transcription of PHO5 gene.	Aspartic Acid	15-18	Pho2p	Saccharomyces cerevisiae S288C	60-64
10884387-6	2000	Since the PHO2 Asp-230 mutant mimics Ser-230-phosphorylated PHO2, we postulate that only phosphorylated PHO2 protein could activate the transcription of PHO5 gene.	Aspartic Acid	15-18	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	153-157
11030753-11	2000	This correlates with reduced activity of the cell death effector protease, caspase-3, in lysates of NAIP-PC12 cells, as measured by cleavage of the fluorogenic tetrapeptide substrate Asp-Glu-Val-Asp.	Aspartic Acid	183-186	caspase 3	Rattus norvegicus	75-84
11030753-11	2000	This correlates with reduced activity of the cell death effector protease, caspase-3, in lysates of NAIP-PC12 cells, as measured by cleavage of the fluorogenic tetrapeptide substrate Asp-Glu-Val-Asp.	Aspartic Acid	183-186	NLR family, apoptosis inhibitory protein 6	Rattus norvegicus	100-104
11030753-11	2000	This correlates with reduced activity of the cell death effector protease, caspase-3, in lysates of NAIP-PC12 cells, as measured by cleavage of the fluorogenic tetrapeptide substrate Asp-Glu-Val-Asp.	Aspartic Acid	195-198	caspase 3	Rattus norvegicus	75-84
11030753-11	2000	This correlates with reduced activity of the cell death effector protease, caspase-3, in lysates of NAIP-PC12 cells, as measured by cleavage of the fluorogenic tetrapeptide substrate Asp-Glu-Val-Asp.	Aspartic Acid	195-198	NLR family, apoptosis inhibitory protein 6	Rattus norvegicus	100-104
10924522-7	2000	The peptides Ala(45)-Arg(54), Phe(56)-Val(71), and Asp(72)-Ser(86), derived from sequences of the A1 domain of FXI, acted synergistically to inhibit (125)I-rA1 binding to prothrombin.	Aspartic Acid	51-54	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	156-159
10906123-6	2000	Synthetic peptides containing Asp and Ile, NKDIL and EPDIM derived from the 2nd and the 4th domains, respectively, almost completely blocked cell adhesion mediated by not only wild type betaig-h3 but also each of the 2nd and the 4th domains.	Aspartic Acid	30-33	transforming growth factor beta induced	Homo sapiens	186-195
11069086-3	2000	These data confirm the importance of position 116 for TAP association, and indicate that (1) an aspartic acid at the 116 position can facilitate the interaction, and (2) association with tapasin and calreticulin is affected along with TAP.	Aspartic Acid	96-109	TAP binding protein	Homo sapiens	187-194
11030732-6	2000	These functional changes in PDE activity were mimicked by mutation of the target serine for Erk2 phosphorylation to the negatively charged amino acid, aspartic acid.	Aspartic Acid	151-164	mitogen-activated protein kinase 1	Mus musculus	92-96
11069086-3	2000	These data confirm the importance of position 116 for TAP association, and indicate that (1) an aspartic acid at the 116 position can facilitate the interaction, and (2) association with tapasin and calreticulin is affected along with TAP.	Aspartic Acid	96-109	calreticulin	Homo sapiens	199-211
11018671-7	2000	Measuring matrix aspartate and glutamate levels revealed that the effects of NEM on the steady-state KIC concentration resulted from inhibition of BCATm catalyzed transamination of KIC with matrix glutamate to form leucine.	Aspartic Acid	17-26	branched chain amino acid transaminase 2	Homo sapiens	147-152
11005799-6	2000	The first three-dimensional structure of a member of the NAT family identifies a catalytic triad consisting of aspartate, histidine and cysteine proposed to form the activation mechanism.	Aspartic Acid	111-120	bromodomain containing 2	Homo sapiens	57-60
11011154-7	2000	Fibrinogen bound to purified alpha(5)beta(1) in a time-dependent, specific, and saturable manner in the presence of Mn(2+), and the binding was blocked completely by Arg-Gly-Asp (RGD)-containing peptides and by anti-alpha(5) and anti-alpha(5)beta(1) monoclonal antibodies.	Aspartic Acid	174-177	fibrinogen beta chain	Homo sapiens	0-10
11054275-3	2000	Sequence comparisons reveals a putative caspase-1 cleavage site at aspartic acid 29 of the primary translation product, indicating that mature ChIL-18 might consist of 169 amino acids.	Aspartic Acid	67-80	caspase 1	Gallus gallus	40-49
11054275-3	2000	Sequence comparisons reveals a putative caspase-1 cleavage site at aspartic acid 29 of the primary translation product, indicating that mature ChIL-18 might consist of 169 amino acids.	Aspartic Acid	67-80	interleukin 18	Gallus gallus	143-150
10985787-2	2000	The binding of E12 was localized to the N-terminal, regulatory domain of VanR which contains Asp-55, the residue which accepts the phosphoryl group from His-164 in the activated VanS sensor kinase.	Aspartic Acid	93-96	VanR	Enterococcus faecium	73-77
11000005-1	2000	The two hormones cholecystokinin and gastrin share the same C-terminal sequence of amino acids, namely Gly(29)-Trp(30)-Met(31)-Asp(32)-Phe(33)-NH(2).	Aspartic Acid	127-130	gastrin	Homo sapiens	37-44
11000005-10	2000	The results suggest that CCK(1) and CCK(2) receptors recognize enatiomeric dispositions of the Trp(30) indole, Asp(32) carboxylic acid, and C-terminal phenyl groups arrayed about a common backbone configuration.	Aspartic Acid	111-114	C-C motif chemokine ligand 28	Homo sapiens	25-31
11000005-10	2000	The results suggest that CCK(1) and CCK(2) receptors recognize enatiomeric dispositions of the Trp(30) indole, Asp(32) carboxylic acid, and C-terminal phenyl groups arrayed about a common backbone configuration.	Aspartic Acid	111-114	cholecystokinin	Homo sapiens	25-28
11372382-11	2000	CONCLUSIONS: PAF plays an important role in acute lung injury in porcine ASP, which may be associated with the increments of PMN sequestration, NE and the highly activated PLA2 in lung and tracheal mucosa.	Aspartic Acid	73-76	phospholipase A2, major isoenzyme	Sus scrofa	172-176
10985787-2	2000	The binding of E12 was localized to the N-terminal, regulatory domain of VanR which contains Asp-55, the residue which accepts the phosphoryl group from His-164 in the activated VanS sensor kinase.	Aspartic Acid	93-96	VanS protein	Enterococcus faecium	178-182
10985790-5	2000	Replacement of the CK II or PK C sites with Asp (MIIB(alpha)(F47)-CK-5D or -PK-4D) strongly inhibited the filament assembly, with or without Mg(2+), by significantly increasing the critical concentrations for assembly.	Aspartic Acid	44-47	proline rich transmembrane protein 2	Homo sapiens	28-32
10998238-1	2000	Integrin alpha(V)beta(3) plays a crucial role in angiogenesis, apoptosis, and bone remodeling, mainly by interacting with matrix proteins through recognition of an Arg-Gly-Asp (RGD) motif.	Aspartic Acid	172-175	integrin subunit alpha V	Homo sapiens	0-24
10878019-3	2000	We mutated the important contact sites Glu-89, Asn-90, and Asn-130 in RGS16 to lysine, aspartate, and alanine, respectively.	Aspartic Acid	87-96	regulator of G-protein signaling 16	Rattus norvegicus	70-75
10975859-4	2000	Both caspase-3 inhibitor Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-CH2F and caspase-9 inhibitor Z-Leu-Glu(OCH3)-His-Asp(OCH3)-CH2F prevented the chondrocyte death.	Aspartic Acid	27-30	caspase 3	Homo sapiens	5-14
10942735-11	2000	Mutation of the Y1087 congener in KCC1 to aspartate also dramatically inhibited cotransporter activity.	Aspartic Acid	42-51	solute carrier family 12 member 4	Homo sapiens	34-38
10823838-6	2000	This observation led to the identification of amino acid residues, Leu(397), Ala(406), Asp(410), and Pro(415), in this region of gelatinase B that are important for its efficient catalysis as determined by substituting these amino acids with the corresponding residues from fibroblast collagenase.	Aspartic Acid	87-90	matrix metallopeptidase 1	Homo sapiens	274-296
10987435-2	2000	Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10-50 microM) affinity for EBP; "dimerization" of the most potent analogues by coupling with linear diamines led to EPO competitors having 1-2 microM binding affinities.	Aspartic Acid	23-36	EBP cholestenol delta-isomerase	Homo sapiens	111-114
10987435-2	2000	Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10-50 microM) affinity for EBP; "dimerization" of the most potent analogues by coupling with linear diamines led to EPO competitors having 1-2 microM binding affinities.	Aspartic Acid	23-36	erythropoietin	Homo sapiens	200-203
10964557-2	2000	Caspases are cysteine proteases that are specific for substrates with an aspartic acid residue at the P(1) position and have an optimal recognition motif that incorporates four amino acid residues N-terminal to the cleavage site.	Aspartic Acid	73-86	caspase 8	Homo sapiens	0-8
10964557-7	2000	In view of this finding, the original classification of caspases into three specificity groups needs to be modified, at least for caspase-8, which tolerates small hydrophobic residues as well as the acidic residue Asp in subsite S(4).	Aspartic Acid	214-217	caspase 8	Homo sapiens	56-64
10964557-7	2000	In view of this finding, the original classification of caspases into three specificity groups needs to be modified, at least for caspase-8, which tolerates small hydrophobic residues as well as the acidic residue Asp in subsite S(4).	Aspartic Acid	214-217	caspase 8	Homo sapiens	130-139
10947972-5	2000	The S(1) subsite, the major specificity-determining site of the caspases, demonstrates tremendous selectivity, with a 20000-fold preference for cleaving substrates containing aspartic acid over glutamic acid at this position.	Aspartic Acid	175-188	caspase 1	Homo sapiens	64-72
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Aspartic Acid	102-105	EcoRII restriction enzyme	Escherichia coli	130-136
10856299-0	2000	Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-32	presenilin 2	Homo sapiens	109-121
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Aspartic Acid	102-105	EcoRII restriction enzyme	Escherichia coli	33-39
10856299-0	2000	Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-32	presenilin 1	Homo sapiens	92-104
10825159-0	2000	The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM.	Aspartic Acid	60-69	Death regulator Nedd2-like caspase	Drosophila melanogaster	23-28
10825159-0	2000	The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM.	Aspartic Acid	60-69	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	90-95
10825159-3	2000	Here we show that the Drosophila caspase DRONC cleaves COOH-terminal to glutamate as well as aspartate.	Aspartic Acid	93-102	Death regulator Nedd2-like caspase	Drosophila melanogaster	41-46
10856299-0	2000	Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-31	presenilin 1	Homo sapiens	92-104
10825159-4	2000	DRONC autoprocesses itself following a glutamate residue, but processes a second caspase, drICE, following an aspartate.	Aspartic Acid	110-119	Death regulator Nedd2-like caspase	Drosophila melanogaster	0-5
10856299-0	2000	Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-31	presenilin 2	Homo sapiens	109-121
10856299-5	2000	Aspartate mutant presenilin holoproteins also preclude entry of endogenous wild type PS1/PS2 into the high MW complexes but do not affect the incorporation of wild type holoproteins into lower MW holoprotein complexes.	Aspartic Acid	0-9	presenilin 1	Homo sapiens	85-88
10825159-5	2000	DRONC prefers tetrapeptide substrates in which aliphatic amino acids are present at the P2 position, and the P1 residue can be either aspartate or glutamate.	Aspartic Acid	134-143	Death regulator Nedd2-like caspase	Drosophila melanogaster	0-5
10856299-5	2000	Aspartate mutant presenilin holoproteins also preclude entry of endogenous wild type PS1/PS2 into the high MW complexes but do not affect the incorporation of wild type holoproteins into lower MW holoprotein complexes.	Aspartic Acid	0-9	presenilin 2	Homo sapiens	89-92
10953054-11	2000	Alteration of Pro(145) into a tyrosine, of Val(317) into a glutamic acid, and insertion of a 32-nucleotide segment resulting in a frameshift distal to Asp(137) all resulted in GRP receptors incapable of binding ligand.	Aspartic Acid	151-154	gastrin releasing peptide	Homo sapiens	176-179
11040259-2	2000	NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1.	Aspartic Acid	42-51	N-terminal Asn amidase	Mus musculus	0-5
11040259-2	2000	NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1.	Aspartic Acid	42-51	arginyltransferase 1	Mus musculus	88-92
10942578-7	2000	The amino acid arginine, which is present in the MSH peptide pharmacophore (HFRW), is also in the most active domain of ASP (KVARP).	Aspartic Acid	120-123	pro-opiomelanocortin-alpha	Mus musculus	49-52
10851236-7	2000	Mutation of a conserved aspartate (Asp(136)) to alanine abolishes both nuclease activities of Sfn.	Aspartic Acid	24-33	RNA exonuclease 2	Homo sapiens	94-97
10823823-0	2000	Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.	Aspartic Acid	56-59	caspase 3	Homo sapiens	82-91
10966646-4	2000	The primary specificity for Asp occurs through a side-on interaction with Arg 226, a buried Arg side chain of granzyme B.	Aspartic Acid	28-31	granzyme B	Homo sapiens	110-120
11007316-2	2000	It has been reported that a negatively charged aspartate residue at position 172 in IRK1 is responsible for Cs+ block of the channel.	Aspartic Acid	47-56	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	84-88
11007316-3	2000	IRK1, a homotetramer, has four aspartate residues at this position.	Aspartic Acid	31-40	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	0-4
11007316-4	2000	GIRK1/GIRK4 is a heterotetramer and has two aspartate residues at the equivalent position (GIRK1-D173) and, consequently, it should be less sensitive to Cs+.	Aspartic Acid	44-53	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	0-5
11007316-4	2000	GIRK1/GIRK4 is a heterotetramer and has two aspartate residues at the equivalent position (GIRK1-D173) and, consequently, it should be less sensitive to Cs+.	Aspartic Acid	44-53	potassium inwardly rectifying channel subfamily J member 5 L homeolog	Xenopus laevis	6-11
11007316-4	2000	GIRK1/GIRK4 is a heterotetramer and has two aspartate residues at the equivalent position (GIRK1-D173) and, consequently, it should be less sensitive to Cs+.	Aspartic Acid	44-53	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	91-96
10823823-8	2000	Asp-Arg-Val-Asp(29)-Glu, Asp-Ile-Val-Asp(208)-Arg, and Asp-Asp-Ser-Asp(633)-Ala were identified as the principal caspase-3 cleavage sites; Asp-Asp-Ser-Asp(633)-Ala was key in the formation of the 74-kDa fragment.	Aspartic Acid	0-3	caspase 3	Homo sapiens	113-122
10823823-0	2000	Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.	Aspartic Acid	60-63	caspase 3	Homo sapiens	82-91
10823823-10	2000	In conclusion, the data support a model in which increased phosphorylation of alpha-adducin due to cisplatin leads to dissociation from the cytoskeleton, a situation rendered irreversible by caspase-3-mediated cleavage of alpha-adducin at Asp-Asp-Ser-Asp(633)-Ala.	Aspartic Acid	239-242	adducin 1	Homo sapiens	78-91
10926824-1	2000	We describe three mutations of the red-cell anion exchangerband 3 (AE1, SLC4A1) gene associated with distalrenal tubular acidosis (dRTA) in families from Malaysia and Papua NewGuinea: Gly(701)--&gt;Asp (G701D), Ala(858)--&gt;Asp(A858D) and deletion of Val(850) (DeltaV850).	Aspartic Acid	198-201	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	67-70
10823823-10	2000	In conclusion, the data support a model in which increased phosphorylation of alpha-adducin due to cisplatin leads to dissociation from the cytoskeleton, a situation rendered irreversible by caspase-3-mediated cleavage of alpha-adducin at Asp-Asp-Ser-Asp(633)-Ala.	Aspartic Acid	239-242	caspase 3	Homo sapiens	191-200
10823823-10	2000	In conclusion, the data support a model in which increased phosphorylation of alpha-adducin due to cisplatin leads to dissociation from the cytoskeleton, a situation rendered irreversible by caspase-3-mediated cleavage of alpha-adducin at Asp-Asp-Ser-Asp(633)-Ala.	Aspartic Acid	243-246	adducin 1	Homo sapiens	78-91
10823823-10	2000	In conclusion, the data support a model in which increased phosphorylation of alpha-adducin due to cisplatin leads to dissociation from the cytoskeleton, a situation rendered irreversible by caspase-3-mediated cleavage of alpha-adducin at Asp-Asp-Ser-Asp(633)-Ala.	Aspartic Acid	243-246	caspase 3	Homo sapiens	191-200
10823823-10	2000	In conclusion, the data support a model in which increased phosphorylation of alpha-adducin due to cisplatin leads to dissociation from the cytoskeleton, a situation rendered irreversible by caspase-3-mediated cleavage of alpha-adducin at Asp-Asp-Ser-Asp(633)-Ala.	Aspartic Acid	243-246	adducin 1	Homo sapiens	78-91
10823823-10	2000	In conclusion, the data support a model in which increased phosphorylation of alpha-adducin due to cisplatin leads to dissociation from the cytoskeleton, a situation rendered irreversible by caspase-3-mediated cleavage of alpha-adducin at Asp-Asp-Ser-Asp(633)-Ala.	Aspartic Acid	243-246	caspase 3	Homo sapiens	191-200
10926824-1	2000	We describe three mutations of the red-cell anion exchangerband 3 (AE1, SLC4A1) gene associated with distalrenal tubular acidosis (dRTA) in families from Malaysia and Papua NewGuinea: Gly(701)--&gt;Asp (G701D), Ala(858)--&gt;Asp(A858D) and deletion of Val(850) (DeltaV850).	Aspartic Acid	198-201	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	72-78
10933781-7	2000	However, mutation of the corresponding valine 379 of phenylalanine hydroxylase to aspartate was not sufficient to allow phenylalanine hydroxylase to form dihydroxyphenylalanine at rates comparable to that of tyrosine hydroxylase.	Aspartic Acid	82-91	phenylalanine hydroxylase	Homo sapiens	53-78
10933816-7	2000	It is concluded that upon mutation of aspartate 804 the affinity of the cation-binding pocket is changed relatively in favor of Na(+) instead of K(+), as a consequence of which the enzyme has obtained a preference for the E(1) conformation.	Aspartic Acid	38-47	carboxylesterase 1C	Rattus norvegicus	222-226
10926824-1	2000	We describe three mutations of the red-cell anion exchangerband 3 (AE1, SLC4A1) gene associated with distalrenal tubular acidosis (dRTA) in families from Malaysia and Papua NewGuinea: Gly(701)--&gt;Asp (G701D), Ala(858)--&gt;Asp(A858D) and deletion of Val(850) (DeltaV850).	Aspartic Acid	225-228	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	67-70
10926824-1	2000	We describe three mutations of the red-cell anion exchangerband 3 (AE1, SLC4A1) gene associated with distalrenal tubular acidosis (dRTA) in families from Malaysia and Papua NewGuinea: Gly(701)--&gt;Asp (G701D), Ala(858)--&gt;Asp(A858D) and deletion of Val(850) (DeltaV850).	Aspartic Acid	225-228	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	72-78
10816586-3	2000	NEST comprises residues 727-1216 of human NTE, and site-directed mutagenesis revealed that serine 966 and two aspartate residues, Asp(1086) and Asp(960), are critical for catalysis.	Aspartic Acid	110-119	patatin like phospholipase domain containing 6	Homo sapiens	42-45
10963786-6	2000	Blocking of GPIIb-IIIa by Arg-Gly-Asp-Ser peptide prevented platelet adhesion to the polystyrene while an extensive adhesion of single platelets to extracellular matrix was observed.	Aspartic Acid	34-37	integrin subunit alpha 2b	Homo sapiens	12-17
10816586-3	2000	NEST comprises residues 727-1216 of human NTE, and site-directed mutagenesis revealed that serine 966 and two aspartate residues, Asp(1086) and Asp(960), are critical for catalysis.	Aspartic Acid	130-133	patatin like phospholipase domain containing 6	Homo sapiens	42-45
10816586-3	2000	NEST comprises residues 727-1216 of human NTE, and site-directed mutagenesis revealed that serine 966 and two aspartate residues, Asp(1086) and Asp(960), are critical for catalysis.	Aspartic Acid	144-147	patatin like phospholipase domain containing 6	Homo sapiens	42-45
10891503-5	2000	Plectin was quantitatively cleaved by caspase 8 at Asp 2395 in the center of the molecule in all cells tested.	Aspartic Acid	51-54	plectin	Homo sapiens	0-7
11003134-3	2000	These analogues were designed looking for suppressors of EAE induced by guinea pig MBP(72-85) epitope (Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-Pro-Val) in Lewis rats.	Aspartic Acid	131-134	myelin basic protein	Cavia porcellus	83-86
11014594-2	2000	Specifically, the remote correlation between the guanidinium nitrogen 15Nepsilon of arginine 71, which serves as the hydrogen donor, and the acceptor carboxylate carbon 13CO2gamma of aspartate 100 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3h JNepsilonCO2gamma coupling by employing a novel HNCO-type experiment, soft CPD-HNCO.	Aspartic Acid	183-192	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	224-230
10825158-3	2000	The coreceptor activity of CXCR4 was markedly impaired by mutations of two Tyr residues in NT (Y7A/Y12A) or at a single Asp residue in ECL2 (D193A), ECL3 (D262A), or TMII (D97N).	Aspartic Acid	120-123	C-X-C motif chemokine receptor 4	Homo sapiens	27-32
10825158-7	2000	Residues required for both SDF-1 binding and signaling, and thus probably part of site II, were identified in ECL2 (Asp(187)), TMII (Asp(97)), and TMVII (Glu(288)).	Aspartic Acid	116-119	C-X-C motif chemokine ligand 12	Homo sapiens	27-32
10825158-7	2000	Residues required for both SDF-1 binding and signaling, and thus probably part of site II, were identified in ECL2 (Asp(187)), TMII (Asp(97)), and TMVII (Glu(288)).	Aspartic Acid	133-136	C-X-C motif chemokine ligand 12	Homo sapiens	27-32
10827088-4	2000	We also examined the corresponding region of CCR5 and demonstrate that the substitution of the serine residue in the homologous ecl-2 position with aspartic acid impairs CCR5 coreceptor activity for isolates across several clades.	Aspartic Acid	148-161	C-C motif chemokine receptor 5	Homo sapiens	45-49
10827088-4	2000	We also examined the corresponding region of CCR5 and demonstrate that the substitution of the serine residue in the homologous ecl-2 position with aspartic acid impairs CCR5 coreceptor activity for isolates across several clades.	Aspartic Acid	148-161	C-C motif chemokine receptor 5	Homo sapiens	170-174
10938011-9	2000	In vitro studies of the function of NOV protein showed that it promoted VSMC adhesion via a mechanism that was divalent cation and Arg-Gly-Asp independent but that it did not modulate VSMC proliferation or phenotype.	Aspartic Acid	139-142	cellular communication network factor 3	Rattus norvegicus	36-39
10903744-4	2000	The mutations Gly25--&gt;Asp and Gly28--&gt;Glu disrupt the disulfide-bonding arrangement of the protein and cause at least a 5-fold increase in the half-time of secretion of MBP compared with wild-type rat serum MBP.	Aspartic Acid	25-28	myelin basic protein	Homo sapiens	175-178
10899933-0	2000	Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.	Aspartic Acid	0-9	LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1	Cricetulus griseus	77-83
10899933-0	2000	Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.	Aspartic Acid	0-9	LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1	Cricetulus griseus	152-158
10913197-3	2000	Replacement of serine 256 with the phosphomimetic aspartic acid prevents proteasome-dependent proteolysis of FUS, while the serine-256-to-alanine FUS mutant is unstable and susceptible to degradation.	Aspartic Acid	50-63	fused in sarcoma	Mus musculus	109-112
10891503-5	2000	Plectin was quantitatively cleaved by caspase 8 at Asp 2395 in the center of the molecule in all cells tested.	Aspartic Acid	51-54	caspase 8	Homo sapiens	38-47
10915606-3	2000	Our study provides experimental evidence that histidine at position 1658 and aspartic acid at position 1686 constitute together with the previously identified serine at position 1752 (S1752) the catalytic triad of the pestiviral NS3 serine protease.	Aspartic Acid	77-90	KRAS proto-oncogene, GTPase	Homo sapiens	229-232
10922078-2	2000	Two conserved aspartates in transmembrane (TM) domains 6 and 7 of presenilin (PS) 1 are required for Abeta production by gamma-secretase.	Aspartic Acid	14-24	amyloid beta precursor protein	Homo sapiens	101-106
10922078-8	2000	The major portion of intracellular Abeta at steady state was found in the same Golgi/trans-Golgi network-rich vesicles, and Abeta levels in these fractions were markedly reduced when either PS1 TM aspartate was mutated to alanine.	Aspartic Acid	197-206	amyloid beta precursor protein	Homo sapiens	35-40
10922078-9	2000	Furthermore, de novo generation of Abeta in a cell-free microsomal reaction occurred specifically in these same vesicle fractions and was markedly inhibited by mutating either TM aspartate.	Aspartic Acid	179-188	amyloid beta precursor protein	Homo sapiens	35-40
10899452-2	2000	This homozygous C-to-A mutation results in the replacement of a highly conserved alanine at amino acid position 659 with an aspartic acid in the C-terminal domain of the myophosphorylase gene protein, near binding sites for pyridoxal phosphate and glucose.	Aspartic Acid	124-137	glycogen phosphorylase, muscle associated	Homo sapiens	170-186
10913275-2	2000	The facial 2-His-1-carboxylate (Asp/Glu) motif has emerged as the structural paradigm for metal binding in the alpha-ketoglutarate (alpha-KG)-dependent nonheme iron oxygenases.	Aspartic Acid	32-35	viral integration site 1	Homo sapiens	13-18
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Aspartic Acid	79-82	S100 calcium binding protein B	Homo sapiens	15-18
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Aspartic Acid	79-82	acyl-CoA thioesterase 8	Homo sapiens	23-26
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Aspartic Acid	79-82	S100 calcium binding protein B	Homo sapiens	63-66
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Aspartic Acid	123-126	S100 calcium binding protein B	Homo sapiens	15-18
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Aspartic Acid	123-126	acyl-CoA thioesterase 8	Homo sapiens	23-26
10807905-4	2000	Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123).	Aspartic Acid	123-126	S100 calcium binding protein B	Homo sapiens	63-66
10913275-6	2000	Weak homology of His145 and its flanking sequence and the presence of Glu147 fitting the canonical acidic residue of the His-Xaa-Asp/Glu signature are consistent with His145 being a coordinating ligand (His-1).	Aspartic Acid	129-132	viral integration site 1	Homo sapiens	203-208
10801821-4	2000	In TAFI activation, however, alanine mutations cause a 50% reduction at Tyr-337, 67% reductions at Asp-338 and Leu-339, and 90% or greater reductions at Val-340, Asp-341, and Glu-343.	Aspartic Acid	162-165	carboxypeptidase B2	Homo sapiens	3-7
10801821-5	2000	A mutation at Asp-349 in the peptide connecting EGF3 to EGF4 eliminated activity against both TAFI and protein C. Oxidation of Met-388 in the peptide connecting EGF5 to EGF6 reduced the rate of protein C activation by 80% but marginally, if at all, affected the rate of TAFI activation.	Aspartic Acid	14-17	carboxypeptidase B2	Homo sapiens	94-98
10801821-5	2000	A mutation at Asp-349 in the peptide connecting EGF3 to EGF4 eliminated activity against both TAFI and protein C. Oxidation of Met-388 in the peptide connecting EGF5 to EGF6 reduced the rate of protein C activation by 80% but marginally, if at all, affected the rate of TAFI activation.	Aspartic Acid	14-17	carboxypeptidase B2	Homo sapiens	270-274
10956190-6	2000	A linear peptide, Ile-Ile-Trp-D-Trp-Leu-Asp, which presumably forms a similar cyclic conformation, was also shown to be a GnRH agonist.	Aspartic Acid	40-43	gonadotropin releasing hormone 1	Rattus norvegicus	122-126
10951567-5	2000	Mutating W342 to aspartate (D), lysine (K) or histidine (H) also inactivated c-Raf whether assayed as a purified immunoprecipitate or when recruited to the plasma membrane.	Aspartic Acid	17-26	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	77-82
10951567-6	2000	A constitutively active c-Raf can be generated by mutating two regulatory tyrosines to aspartate.	Aspartic Acid	87-96	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	24-29
10919674-5	2000	This apoptotic activity of E1A is accompanied by processing of caspase-3 and cleavage of poly(ADP-ribose) polymerase and can be significantly blocked by z-VAD-fmk Z-Val-Ala-Asp(OCH3)-CH2F and the caspase-3-specific inhibitor Z-DEVD-FMK Z-Asp(OCH3)-Glu-Val-Asp(OCH3)-CH2F.	Aspartic Acid	173-176	caspase 3	Homo sapiens	196-205
10889019-0	2000	Multiple interactions of the Asp(2.61(98)) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction.	Aspartic Acid	29-32	gonadotropin releasing hormone receptor	Homo sapiens	61-100
10889019-1	2000	Mutation of Asp(2.61(98)) at the extracellular boundary of transmembrane helix 2 of the gonadotropin-releasing hormone (GnRH) receptor decreased the affinity for GnRH.	Aspartic Acid	12-15	gonadotropin releasing hormone receptor	Homo sapiens	88-134
10889019-1	2000	Mutation of Asp(2.61(98)) at the extracellular boundary of transmembrane helix 2 of the gonadotropin-releasing hormone (GnRH) receptor decreased the affinity for GnRH.	Aspartic Acid	12-15	gonadotropin releasing hormone 1	Homo sapiens	120-124
10889019-13	2000	These studies support a dual role for Asp(2.61(98)): formation of an interhelical interaction with Lys(3.32(121)) that contributes to the structure of the agonist binding pocket and an interaction with His(2) of GnRH that helps stabilize agonist complexing.	Aspartic Acid	38-41	gonadotropin releasing hormone 1	Homo sapiens	212-216
10945231-5	2000	Bovine PCl contained Asn as the oxyanion hole residue; in contrast, bovine PC2 contained Asp as the oxyanion hole residue, which is identical to PC2 in other mammalian species.	Aspartic Acid	89-92	proprotein convertase subtilisin/kexin type 2	Bos taurus	75-78
10781610-4	2000	Changing Glu-226, which corresponded to the catalytic residue of the cyclase, to Asp, Asn, Gln, Leu, or Gly eliminated essentially all enzymatic activities of CD38, indicating it is most likely the catalytic residue.	Aspartic Acid	81-84	CD38 molecule	Homo sapiens	159-163
10787412-7	2000	This stabilizing role of Asp-351 could be due to interaction of Asp-351 with the amide group of the peptide bond between Leu-539 and Leu-540 in helix 12 observed in the active conformation of the ERalpha ligand binding domain.	Aspartic Acid	64-67	estrogen receptor 1	Homo sapiens	196-203
10873270-7	2000	From these digests the completely deglycosylated polypeptide corresponding to RNase A in which Asn has been converted to Asp (mass 13,684) and a species corresponding to RNase A + GlcNAc (mass 13,886) are produced, together with their corresponding free oligosaccharides which are amenable to analysis by both MALDI-ToF and by HPLC.	Aspartic Acid	121-124	ribonuclease A family member 1, pancreatic	Homo sapiens	78-85
11007004-11	2000	Furthermore, the isolates could be distinguished from the Ark reference strains by a characteristic sequence polymorphism, a six-nucleotide deletion encoding amino acids 57 (Asp) and 58 (Asp) in hypervariable region 1 of S-1.	Aspartic Acid	174-177	proteasome 26S subunit, non-ATPase 1	Homo sapiens	221-224
11007004-11	2000	Furthermore, the isolates could be distinguished from the Ark reference strains by a characteristic sequence polymorphism, a six-nucleotide deletion encoding amino acids 57 (Asp) and 58 (Asp) in hypervariable region 1 of S-1.	Aspartic Acid	187-190	proteasome 26S subunit, non-ATPase 1	Homo sapiens	221-224
10787412-0	2000	Aspartate 351 of estrogen receptor alpha is not crucial for the antagonist activity of antiestrogens.	Aspartic Acid	0-9	estrogen receptor 1	Homo sapiens	17-40
10787412-7	2000	This stabilizing role of Asp-351 could be due to interaction of Asp-351 with the amide group of the peptide bond between Leu-539 and Leu-540 in helix 12 observed in the active conformation of the ERalpha ligand binding domain.	Aspartic Acid	25-28	estrogen receptor 1	Homo sapiens	196-203
10903964-12	2000	Mutations in residues Thr(88), Tyr(92) and Asp(278) greatly reduced affinity for AngII but not for Sar(1) Leu(8)-AngII, suggesting unfavourable interactions between these residues and AngII"s aspartic acid side-chain or N-terminal amino group, which might account for the proposed role of the N-terminal amino group of AngII in the agonist-induced desensitization (tachyphylaxis) of smooth muscles.	Aspartic Acid	43-46	angiotensinogen	Rattus norvegicus	81-86
10903964-12	2000	Mutations in residues Thr(88), Tyr(92) and Asp(278) greatly reduced affinity for AngII but not for Sar(1) Leu(8)-AngII, suggesting unfavourable interactions between these residues and AngII"s aspartic acid side-chain or N-terminal amino group, which might account for the proposed role of the N-terminal amino group of AngII in the agonist-induced desensitization (tachyphylaxis) of smooth muscles.	Aspartic Acid	192-205	angiotensinogen	Rattus norvegicus	81-86
10945231-4	2000	Bovine PC1 and PC2 contained the catalytic triad residues Asp, His, Ser, which are identical to the triads in PC1 and PC2 from other mammalian species.	Aspartic Acid	58-61	proprotein convertase subtilisin/kexin type 1	Bos taurus	7-10
10945231-4	2000	Bovine PC1 and PC2 contained the catalytic triad residues Asp, His, Ser, which are identical to the triads in PC1 and PC2 from other mammalian species.	Aspartic Acid	58-61	proprotein convertase subtilisin/kexin type 2	Bos taurus	15-18
10945231-4	2000	Bovine PC1 and PC2 contained the catalytic triad residues Asp, His, Ser, which are identical to the triads in PC1 and PC2 from other mammalian species.	Aspartic Acid	58-61	proprotein convertase subtilisin/kexin type 2	Bos taurus	118-121
10947842-0	2000	Tuning of the porin expression under anaerobic growth conditions by his-to-Asp cross-phosphorelay through both the EnvZ-osmosensor and ArcB-anaerosensor in Escherichia coli.	Aspartic Acid	75-78	hypothetical protein	Escherichia coli	135-139
10959033-4	2000	Mutating either of two conserved transmembrane aspartates in PS1 significantly reduced Abeta production and increased the APP C-terminal fragments that are gamma-secretase substrates.	Aspartic Acid	47-57	presenilin 1	Mus musculus	61-64
10959033-4	2000	Mutating either of two conserved transmembrane aspartates in PS1 significantly reduced Abeta production and increased the APP C-terminal fragments that are gamma-secretase substrates.	Aspartic Acid	47-57	amyloid beta (A4) precursor protein	Mus musculus	87-92
10782015-2	2000	Direct sequencing identified a heterozygous GAC to GAA substitution altering codon 328 of K5 from Asp to Glu in all affected family members, while no mutation was observed either in the healthy individual or the 50 unrelated control samples.	Aspartic Acid	98-101	keratin 5	Homo sapiens	90-92
10782015-3	2000	Asp(328) of K5 (position 12 in the L12 domain) is remarkably conserved among all type II keratins.	Aspartic Acid	0-3	keratin 5	Homo sapiens	12-14
10782015-4	2000	K5 L12:D12E is the third mutation found to affect this residue in K5-related EBS, indicating the importance of Asp(328) for K5 structure and the dramatic effect that fine changes can have on keratin intermediate filament integrity.	Aspartic Acid	111-114	keratin 5	Homo sapiens	0-2
10782015-4	2000	K5 L12:D12E is the third mutation found to affect this residue in K5-related EBS, indicating the importance of Asp(328) for K5 structure and the dramatic effect that fine changes can have on keratin intermediate filament integrity.	Aspartic Acid	111-114	keratin 5	Homo sapiens	66-68
10860944-3	2000	Substitution of Asp(123)(3.32) in the third transmembrane domain of the receptor resulted in a loss of detectable (125)I-MCH binding and of MCH-stimulated Ca(2+) flux; cell surface expression of the mutant receptor was not affected.	Aspartic Acid	16-19	pro-melanin concentrating hormone	Homo sapiens	121-124
10782015-4	2000	K5 L12:D12E is the third mutation found to affect this residue in K5-related EBS, indicating the importance of Asp(328) for K5 structure and the dramatic effect that fine changes can have on keratin intermediate filament integrity.	Aspartic Acid	111-114	keratin 5	Homo sapiens	66-68
10782017-3	2000	Amongst the IDDM children with heterozygous genotype at codon 57 of HLA DQB1, 6/55 (11%) had Asp/Ala, 8/55 (15%) had Ala/Val, 4/55 (7%) had Ala/Ser and 1/55 had Asp/Val allelic combinations.	Aspartic Acid	93-96	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	68-82
10782017-3	2000	Amongst the IDDM children with heterozygous genotype at codon 57 of HLA DQB1, 6/55 (11%) had Asp/Ala, 8/55 (15%) had Ala/Val, 4/55 (7%) had Ala/Ser and 1/55 had Asp/Val allelic combinations.	Aspartic Acid	161-164	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	68-82
10864577-4	2000	Uptake of ASP(+) via rOCT1 was electrogenic, and its inhibition by other organic cations was consistent with previously reported radioactive tracer flux measurements.	Aspartic Acid	10-16	solute carrier family 22 member 1	Rattus norvegicus	21-26
10860944-3	2000	Substitution of Asp(123)(3.32) in the third transmembrane domain of the receptor resulted in a loss of detectable (125)I-MCH binding and of MCH-stimulated Ca(2+) flux; cell surface expression of the mutant receptor was not affected.	Aspartic Acid	16-19	pro-melanin concentrating hormone	Homo sapiens	140-143
10860944-4	2000	Arg(11) and Arg(14) of the MCH ligand were identified as potential sites of interaction with Asp(123)(3.32).	Aspartic Acid	93-96	pro-melanin concentrating hormone	Homo sapiens	27-30
10860944-9	2000	We conclude that both Asp(123)(3.32) in the MCH receptor and Arg(11) in the MCH peptide are required for the formation of the MCH peptide/receptor complex and propose that they form a direct interaction that is critical for receptor function.	Aspartic Acid	22-25	pro-melanin concentrating hormone	Homo sapiens	44-47
10858286-8	2000	Alanine mutation of Met 147 or Asp 149 completely abolished or significantly decreased, respectively, the level of the PCNA binding and the inhibition of SV40 DNA replication.	Aspartic Acid	31-34	proliferating cell nuclear antigen	Homo sapiens	119-123
10728833-10	2000	The amino-terminal sequence of LM-PLA2 (previously reported) indicates an aspartic acid residue located at position 49, together with other conserved amino acids present in the Asp-49 phospholipases, such as Tyr-28, Gly-30, Gly-32, His-48.	Aspartic Acid	74-87	phospholipase A2, group V	Mus musculus	34-38
10728833-10	2000	The amino-terminal sequence of LM-PLA2 (previously reported) indicates an aspartic acid residue located at position 49, together with other conserved amino acids present in the Asp-49 phospholipases, such as Tyr-28, Gly-30, Gly-32, His-48.	Aspartic Acid	177-180	phospholipase A2, group V	Mus musculus	34-38
10856224-4	2000	A single nucleotide mutation in the cathepsin D gene results in conversion of an active site aspartate to asparagine, leading to production of an enzymatically inactive but stable protein.	Aspartic Acid	93-102	cathepsin D	Homo sapiens	36-47
10841893-12	2000	These results indicate that reversed transport, primarily from glial cells by the EAAT 2 carrier, is responsible for a substantial (42 and 56%) portion of the ischemia-evoked increase in extracellular glutamate and aspartate levels, respectively.	Aspartic Acid	215-224	solute carrier family 1 member 2	Rattus norvegicus	82-88
10747887-2	2000	Cytosolic phospholipase A(2)alpha (cPLA(2)alpha; type IVA), an essential initiator of stimulus-dependent arachidonic acid (AA) metabolism, underwent caspase-mediated cleavage at Asp(522) during apoptosis.	Aspartic Acid	178-181	phospholipase A2 group IVA	Homo sapiens	35-47
10747887-6	2000	iPLA(2) was cleaved at Asp(183) by caspase-3 to a truncated enzyme lacking most of the first ankyrin repeat, and this cleavage resulted in increased iPLA(2) functions.	Aspartic Acid	23-26	phospholipase A2 group VI	Homo sapiens	0-7
10747887-6	2000	iPLA(2) was cleaved at Asp(183) by caspase-3 to a truncated enzyme lacking most of the first ankyrin repeat, and this cleavage resulted in increased iPLA(2) functions.	Aspartic Acid	23-26	caspase 3	Homo sapiens	35-44
10839996-1	2000	Tissue-non-specific alkaline phosphatase (TNSALP) with an Arg(54)--&gt;Cys (R54C) or an Asp(277)--&gt;Ala (D277A)substitution was found in a patient with hypophosphatasia [Henthorn,Raducha, Fedde, Lafferty and Whyte (1992) Proc.	Aspartic Acid	88-91	alkaline phosphatase, biomineralization associated	Homo sapiens	0-40
10748160-2	2000	The mutation of the Asn/Asp residue of this motif in different G-protein-coupled receptors was shown to affect the activation of either adenylyl cyclase or phospholipase C. We have mutated the Asn residue (Asn-391) of the NPXXY motif in the CCKBR to Ala and determined the effects of the mutation on binding, signaling, and G-proteins coupling after expression of the mutated receptor in COS cells.	Aspartic Acid	24-27	cholecystokinin B receptor	Homo sapiens	241-246
10839996-1	2000	Tissue-non-specific alkaline phosphatase (TNSALP) with an Arg(54)--&gt;Cys (R54C) or an Asp(277)--&gt;Ala (D277A)substitution was found in a patient with hypophosphatasia [Henthorn,Raducha, Fedde, Lafferty and Whyte (1992) Proc.	Aspartic Acid	88-91	alkaline phosphatase, biomineralization associated	Homo sapiens	42-48
10871852-7	2000	Forced expression of a dominant negative form of p38 (p38-ASP) or treatment with p38 pharmacological inhibitor, SB203580, increases NF-kappaB activity, Fas expression and the levels of UVC-induced apoptosis in late stage melanoma cells.	Aspartic Acid	58-61	mitogen-activated protein kinase 14	Homo sapiens	49-52
10871852-7	2000	Forced expression of a dominant negative form of p38 (p38-ASP) or treatment with p38 pharmacological inhibitor, SB203580, increases NF-kappaB activity, Fas expression and the levels of UVC-induced apoptosis in late stage melanoma cells.	Aspartic Acid	58-61	mitogen-activated protein kinase 14	Homo sapiens	54-57
10871852-7	2000	Forced expression of a dominant negative form of p38 (p38-ASP) or treatment with p38 pharmacological inhibitor, SB203580, increases NF-kappaB activity, Fas expression and the levels of UVC-induced apoptosis in late stage melanoma cells.	Aspartic Acid	58-61	mitogen-activated protein kinase 14	Homo sapiens	54-57
10748153-9	2000	These mutations were also introduced in an activated PMA2 mutant (Gln-14 --&gt; Asp) characterized by a higher H(+) pumping activity.	Aspartic Acid	80-83	H(+)-exporting P2-type ATPase PMA2	Saccharomyces cerevisiae S288C	53-57
10751404-4	2000	Mutation of Glu-729, Glu-730, and Asp-732 at the C terminus of hsp90 interfered with binding of all three TPR proteins.	Aspartic Acid	34-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-68
10873097-4	2000	An A--&gt;G transition at codon 149 resulted in amino acid substitution from aspartate to glycine in the proliferating cell nuclear antigen binding COOH-terminal domain of p21(Waf1/Cip1) that may affect PCNA-p21(Waf1/Cip1) interactions, thereby affecting regulation of cellular proliferation, and may increase susceptibility for development of cancer.	Aspartic Acid	77-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	181-185
10751404-5	2000	Mutation of Glu-720, Asp-722, Asp-723, and Asp-724 inhibited binding of FKBP52 and PP5 but not of Hop.	Aspartic Acid	21-24	FKBP prolyl isomerase 4	Homo sapiens	72-78
10751404-5	2000	Mutation of Glu-720, Asp-722, Asp-723, and Asp-724 inhibited binding of FKBP52 and PP5 but not of Hop.	Aspartic Acid	21-24	protein phosphatase 5 catalytic subunit	Homo sapiens	83-86
10751404-5	2000	Mutation of Glu-720, Asp-722, Asp-723, and Asp-724 inhibited binding of FKBP52 and PP5 but not of Hop.	Aspartic Acid	30-33	FKBP prolyl isomerase 4	Homo sapiens	72-78
10751404-5	2000	Mutation of Glu-720, Asp-722, Asp-723, and Asp-724 inhibited binding of FKBP52 and PP5 but not of Hop.	Aspartic Acid	30-33	protein phosphatase 5 catalytic subunit	Homo sapiens	83-86
10751404-5	2000	Mutation of Glu-720, Asp-722, Asp-723, and Asp-724 inhibited binding of FKBP52 and PP5 but not of Hop.	Aspartic Acid	30-33	FKBP prolyl isomerase 4	Homo sapiens	72-78
10751404-5	2000	Mutation of Glu-720, Asp-722, Asp-723, and Asp-724 inhibited binding of FKBP52 and PP5 but not of Hop.	Aspartic Acid	30-33	protein phosphatase 5 catalytic subunit	Homo sapiens	83-86
10751404-6	2000	Mutation of Glu-651 and Asp-653 did not affect binding of FKBP52 or PP5 but inhibited both Hop binding and hsp90 chaperone activity.	Aspartic Acid	24-27	stress induced phosphoprotein 1	Homo sapiens	91-94
10751404-6	2000	Mutation of Glu-651 and Asp-653 did not affect binding of FKBP52 or PP5 but inhibited both Hop binding and hsp90 chaperone activity.	Aspartic Acid	24-27	heat shock protein 90 alpha family class A member 1	Homo sapiens	107-112
10842714-2	2000	The SAA1 exon 4 was amplified by PCR and treated with Nco I. Sequencing of PCR products from genomic DNA of individuals who were heterozygous for the Nco I site revealed GGT (Gly) and GAT (Asp) at the position 72.	Aspartic Acid	189-192	serum amyloid A1	Homo sapiens	4-8
10845864-4	2000	Cultured VSMCs from Wistar-Kyoto rats were incubated with an active fragment of FN, Arg-Gly-Asp-Ser, for 24, 48, or 72 hours after synchronization of the cell cycle with 0.	Aspartic Acid	92-95	fibronectin 1	Rattus norvegicus	80-82
10833413-2	2000	All these conjugates (AdoOC(O)Asp(n), n = 1-4) inhibited the 2MeSADP-stimulated synthesis of inositol phosphates in 1321N1 human astrocytoma cells stably expressing human P2Y(1) receptors.	Aspartic Acid	30-33	purinergic receptor P2Y1	Homo sapiens	171-177
10748036-4	2000	The binding protein also binds insulin-like growth factors I and II, proinsulin, mini-proinsulin, and an insulin analog lacking the last 8 amino acids of the B-chain (des-octa peptide insulin) with high affinity, whereas an insulin analog with a Asp-B10 mutation bound with only 1% of the affinity of human insulin.	Aspartic Acid	246-249	insulin like growth factor 1	Homo sapiens	31-67
10748036-4	2000	The binding protein also binds insulin-like growth factors I and II, proinsulin, mini-proinsulin, and an insulin analog lacking the last 8 amino acids of the B-chain (des-octa peptide insulin) with high affinity, whereas an insulin analog with a Asp-B10 mutation bound with only 1% of the affinity of human insulin.	Aspartic Acid	246-249	insulin	Homo sapiens	69-79
10748036-4	2000	The binding protein also binds insulin-like growth factors I and II, proinsulin, mini-proinsulin, and an insulin analog lacking the last 8 amino acids of the B-chain (des-octa peptide insulin) with high affinity, whereas an insulin analog with a Asp-B10 mutation bound with only 1% of the affinity of human insulin.	Aspartic Acid	246-249	insulin	Homo sapiens	86-96
10748036-4	2000	The binding protein also binds insulin-like growth factors I and II, proinsulin, mini-proinsulin, and an insulin analog lacking the last 8 amino acids of the B-chain (des-octa peptide insulin) with high affinity, whereas an insulin analog with a Asp-B10 mutation bound with only 1% of the affinity of human insulin.	Aspartic Acid	246-249	insulin	Homo sapiens	31-38
10748036-4	2000	The binding protein also binds insulin-like growth factors I and II, proinsulin, mini-proinsulin, and an insulin analog lacking the last 8 amino acids of the B-chain (des-octa peptide insulin) with high affinity, whereas an insulin analog with a Asp-B10 mutation bound with only 1% of the affinity of human insulin.	Aspartic Acid	246-249	insulin	Homo sapiens	72-79
10748036-4	2000	The binding protein also binds insulin-like growth factors I and II, proinsulin, mini-proinsulin, and an insulin analog lacking the last 8 amino acids of the B-chain (des-octa peptide insulin) with high affinity, whereas an insulin analog with a Asp-B10 mutation bound with only 1% of the affinity of human insulin.	Aspartic Acid	246-249	insulin	Homo sapiens	72-79
10748036-4	2000	The binding protein also binds insulin-like growth factors I and II, proinsulin, mini-proinsulin, and an insulin analog lacking the last 8 amino acids of the B-chain (des-octa peptide insulin) with high affinity, whereas an insulin analog with a Asp-B10 mutation bound with only 1% of the affinity of human insulin.	Aspartic Acid	246-249	insulin	Homo sapiens	72-79
10822279-6	2000	Furthermore, addition of cytochrome c to Jurkat post-nuclear extracts triggered breakdown of BID at Asp-59 which was catalysed by caspase-3 rather than caspase-8.	Aspartic Acid	100-103	cytochrome c, somatic	Homo sapiens	25-37
10822279-6	2000	Furthermore, addition of cytochrome c to Jurkat post-nuclear extracts triggered breakdown of BID at Asp-59 which was catalysed by caspase-3 rather than caspase-8.	Aspartic Acid	100-103	BH3 interacting domain death agonist	Homo sapiens	93-96
10822279-6	2000	Furthermore, addition of cytochrome c to Jurkat post-nuclear extracts triggered breakdown of BID at Asp-59 which was catalysed by caspase-3 rather than caspase-8.	Aspartic Acid	100-103	caspase 3	Homo sapiens	130-139
10873097-4	2000	An A--&gt;G transition at codon 149 resulted in amino acid substitution from aspartate to glycine in the proliferating cell nuclear antigen binding COOH-terminal domain of p21(Waf1/Cip1) that may affect PCNA-p21(Waf1/Cip1) interactions, thereby affecting regulation of cellular proliferation, and may increase susceptibility for development of cancer.	Aspartic Acid	77-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	172-175
10873097-4	2000	An A--&gt;G transition at codon 149 resulted in amino acid substitution from aspartate to glycine in the proliferating cell nuclear antigen binding COOH-terminal domain of p21(Waf1/Cip1) that may affect PCNA-p21(Waf1/Cip1) interactions, thereby affecting regulation of cellular proliferation, and may increase susceptibility for development of cancer.	Aspartic Acid	77-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	176-180
10837245-7	2000	Mutating these sites to non-phosphorylatable residues abolished Ste11p function, whereas changing them to aspartic acid to mimic the phosphorylated form constitutively activated Ste11p in vivo in a Ste20p-independent manner.	Aspartic Acid	106-119	mitogen-activated protein kinase kinase kinase STE11	Saccharomyces cerevisiae S288C	178-184
10873097-4	2000	An A--&gt;G transition at codon 149 resulted in amino acid substitution from aspartate to glycine in the proliferating cell nuclear antigen binding COOH-terminal domain of p21(Waf1/Cip1) that may affect PCNA-p21(Waf1/Cip1) interactions, thereby affecting regulation of cellular proliferation, and may increase susceptibility for development of cancer.	Aspartic Acid	77-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	208-211
10805935-2	2000	The resulting enzyme is able to cleave several target proteins after the second aspartate of a DEVD sequence common to all the substrates of caspases 3 and 7 (DEVDase).	Aspartic Acid	80-89	caspase 3	Homo sapiens	141-167
10873097-4	2000	An A--&gt;G transition at codon 149 resulted in amino acid substitution from aspartate to glycine in the proliferating cell nuclear antigen binding COOH-terminal domain of p21(Waf1/Cip1) that may affect PCNA-p21(Waf1/Cip1) interactions, thereby affecting regulation of cellular proliferation, and may increase susceptibility for development of cancer.	Aspartic Acid	77-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	212-216
10873097-4	2000	An A--&gt;G transition at codon 149 resulted in amino acid substitution from aspartate to glycine in the proliferating cell nuclear antigen binding COOH-terminal domain of p21(Waf1/Cip1) that may affect PCNA-p21(Waf1/Cip1) interactions, thereby affecting regulation of cellular proliferation, and may increase susceptibility for development of cancer.	Aspartic Acid	77-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	217-221
10833311-4	2000	Transgenic mice expressing the 695 amino acid form of the human APP from the Thy-1 promoter showed a significant decrease in B(max) and K(D) for aspartate uptake when compared to nontransgenic controls.	Aspartic Acid	145-154	Thy-1 cell surface antigen	Homo sapiens	77-82
10871340-0	2000	Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.	Aspartic Acid	16-19	huntingtin associated protein 1	Homo sapiens	27-31
10842059-3	2000	In a two-hybrid screen for additional components of the pathway using the Drosophila I-kappaB protein Cactus as a bait, we isolated a novel coiled-coil protein with N-terminal Arg-Asp (RD)- like motifs that we call Cactin.	Aspartic Acid	180-183	cactin	Drosophila melanogaster	215-221
10871340-0	2000	Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.	Aspartic Acid	16-19	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	33-36
10871340-0	2000	Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.	Aspartic Acid	16-19	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	37-42
10871340-2	2000	Previous structural studies have suggested a possible role for the Asp-210 residue of HAP1 in the enzymatic function of this enzyme.	Aspartic Acid	67-70	huntingtin associated protein 1	Homo sapiens	86-90
10871340-5	2000	These results indicate that Asp-210 is required for catalysis, but not substrate recognition, consistent with enzyme kinetic data indicating that the HAP1-D210E protein has a 3000-fold reduced K(cat )for AP site cleavage, but an unchanged K(m).	Aspartic Acid	28-31	huntingtin associated protein 1	Homo sapiens	150-154
10871340-6	2000	Through analysis of the binding of Asp-210 substitution mutants to oligonucleotides containing either an AP site or a pBQ adduct, we conclude that the absence of Asp-210 allows the formation of a stable HAP1-substrate complex that exists only transiently during the catalytic cycle of wild-type HAP1 protein.	Aspartic Acid	35-38	huntingtin associated protein 1	Homo sapiens	203-207
10871340-6	2000	Through analysis of the binding of Asp-210 substitution mutants to oligonucleotides containing either an AP site or a pBQ adduct, we conclude that the absence of Asp-210 allows the formation of a stable HAP1-substrate complex that exists only transiently during the catalytic cycle of wild-type HAP1 protein.	Aspartic Acid	162-165	huntingtin associated protein 1	Homo sapiens	203-207
10945337-6	2000	The putative polypeptide is rich in lysine (K), glutamic acid (E) and aspartic acid (D), which constitute up to 70% of total amino acids, and was therefore designated as KED.	Aspartic Acid	70-83	DNA ligase 1-like	Nicotiana tabacum	170-173
10788459-7	2000	Enzymatic characterization showed that, of the twelve mutated M-PSTs, mutations at residues Asp-86, Glu-89, and Glu-146 resulted in a dramatic decrease in V(max)/K(m) with dopamine as substrate, being greater than 450 times for the D86A/E89I/E146A mutated M-PST.	Aspartic Acid	92-95	mercaptopyruvate sulfurtransferase	Homo sapiens	62-67
10860730-2	2000	IFN-gamma SC1 was derived by linking the two peptide chains of the IFN-gamma dimer by a seven-residue linker and changing His111 in the first chain to an aspartic acid residue.	Aspartic Acid	154-167	interferon gamma	Homo sapiens	0-9
10860730-2	2000	IFN-gamma SC1 was derived by linking the two peptide chains of the IFN-gamma dimer by a seven-residue linker and changing His111 in the first chain to an aspartic acid residue.	Aspartic Acid	154-167	transcription factor 19	Homo sapiens	10-13
10860730-6	2000	As a result, surface charge rather than structural changes is likely responsible for the inability of the His111--&gt;Asp domain of to bind IFN-gamma R alpha.	Aspartic Acid	118-121	interferon gamma	Homo sapiens	140-149
10799485-3	2000	Like yeast Ulp1, SUSP1 is a cysteine protease containing the well conserved His/Asp/Cys catalytic triad.	Aspartic Acid	80-83	SUMO protease ULP1	Saccharomyces cerevisiae S288C	11-15
10799485-3	2000	Like yeast Ulp1, SUSP1 is a cysteine protease containing the well conserved His/Asp/Cys catalytic triad.	Aspartic Acid	80-83	SUMO specific peptidase 6	Homo sapiens	17-22
10814707-4	2000	RERE also contains arginine-aspartic acid (RD) dipeptide repeats and putative nuclear localization signal sequences, but no polyglutamine tracts.	Aspartic Acid	28-41	arginine-glutamic acid dipeptide repeats	Homo sapiens	0-4
10799519-1	2000	We created a novel mutated form of human interleukin-13 (IL-13) in which a positively charged arginine (R) at position 112 was substituted to a negatively charged aspartic acid (D).	Aspartic Acid	163-176	interleukin 13	Homo sapiens	41-55
10799519-1	2000	We created a novel mutated form of human interleukin-13 (IL-13) in which a positively charged arginine (R) at position 112 was substituted to a negatively charged aspartic acid (D).	Aspartic Acid	163-176	interleukin 13	Homo sapiens	57-62
10851034-5	2000	Two amino acid substitutions, Val-56--&gt;Ala-56 and Asp-64--&gt;Ser-64, were revealed in Cp2, as compared to the watermelon strain of the virus.	Aspartic Acid	53-56	ceruloplasmin	Homo sapiens	90-93
10736265-9	2000	Resequencing of the GK gene in family members led to the discovery of a N288D missense mutation in exon 10, which resulted in the substitution of a highly conserved asparagine residue by a negatively charged aspartic acid.	Aspartic Acid	208-221	glycerol kinase	Homo sapiens	20-22
10837925-6	2000	More interestingly, the product of N-acetylasparagine was aspartate but not asparagine, indicating that ASPA catalyzed deacetylation as well as hydrolysis of the beta acid amide.	Aspartic Acid	58-67	aspartoacylase	Homo sapiens	104-108
10870516-2	2000	The selective adenosine A2A receptor antagonist, 4-[2-[7-amino-2-(2-furyl)(1,2,4)-triazin-5-ylamino]-ethyl]ph enol (ZM241385) (50 nM), increased the release of glutamate (three- to four-fold) and of aspartate (nearly two-fold) upon iodoacetic acid-induced glycolysis inhibition, in the presence or in the absence of Ca2+.	Aspartic Acid	199-208	adenosine A2a receptor	Gallus gallus	14-36
10870516-7	2000	Furthermore, the GABAA receptor antagonist, bicuculline (10 microM), only increased (nearly two-fold) the iodoacetic acid-induced Ca(2+)-dependent release of glutamate, whereas the GABAB receptor antagonist, 3-aminopropyl(diethoxymethyl) phosphinic acid, CGP35348 (100 microM), was devoid of effects on the extracellular accumulation of glutamate and aspartate.	Aspartic Acid	351-360	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	17-31
10866110-8	2000	Pig DAP12 has a conserved aspartic acid in the transmembrane region, and two conserved cysteine residues in the extracellular domain.	Aspartic Acid	26-39	TYRO protein tyrosine kinase binding protein	Mus musculus	4-9
10773347-3	2000	The Arg-Gly-Asp sequence (RGD), is recognized by many integrins, including integrin alphavbeta3 (CD51/61).	Aspartic Acid	12-15	integrin subunit alpha V	Homo sapiens	75-95
10773347-4	2000	Coxsackievirus A9 (CAV-9), a human pathogen that has an Arg-Gly-Asp sequence in the VP1 capsid protein, has been known to be one of the many viruses that utilise integrin alphavbeta3 as a receptor.	Aspartic Acid	64-67	integrin subunit alpha V	Homo sapiens	162-182
10802344-0	2000	BDNF rapidly induces aspartate release from cultured CNS neurons.	Aspartic Acid	21-30	brain derived neurotrophic factor	Homo sapiens	0-4
10788795-1	2000	The ArcB sensor plays a crucial role in the histidine to aspartate (His-to-Asp) phosphorelay signal transduction, which is involved in the transcriptional regulatory network that allows Escherichia coli cells to sense various respiratory growth conditions.	Aspartic Acid	57-66	hypothetical protein	Escherichia coli	4-8
10788795-1	2000	The ArcB sensor plays a crucial role in the histidine to aspartate (His-to-Asp) phosphorelay signal transduction, which is involved in the transcriptional regulatory network that allows Escherichia coli cells to sense various respiratory growth conditions.	Aspartic Acid	75-78	hypothetical protein	Escherichia coli	4-8
10788795-2	2000	ArcB is one of the best-studied hybrid His-kinases involved in the multi-step His-to-Asp phosphorelay.	Aspartic Acid	85-88	hypothetical protein	Escherichia coli	0-4
10779384-4	2000	The PDE4D3 Asp-Asn mutant was resistant to inhibition by rolipram as well as several other PDE4 inhibitors tested.	Aspartic Acid	11-14	phosphodiesterase 4D	Homo sapiens	4-9
10779384-4	2000	The PDE4D3 Asp-Asn mutant was resistant to inhibition by rolipram as well as several other PDE4 inhibitors tested.	Aspartic Acid	11-14	phosphodiesterase 4A	Homo sapiens	4-8
10779384-6	2000	Sequence comparison of PDE4 with cGMP-specific PDE proteins shows a conserved aspartic acid at position 333 in PDE4D3 and a conserved asparagine at this position in PDE enzymes that hydrolyze cGMP.	Aspartic Acid	78-91	phosphodiesterase 4A	Homo sapiens	23-27
10779384-8	2000	PDE4D3 Asp-Asn hydrolyzes cGMP with kinetic constants similar to those observed for this protein with cAMP (K(m) approximately 20 microM, V(max) approximately 2 micromol AMP/min/mg recombinant protein).	Aspartic Acid	7-10	phosphodiesterase 4D	Homo sapiens	0-5
10779384-10	2000	In addition, the PDE4D3 Asp-Ala mutant protein could hydrolyze cGMP.	Aspartic Acid	24-27	phosphodiesterase 4D	Homo sapiens	17-22
10779384-12	2000	These results show that this aspartic acid residue is important in inhibitor binding and nucleotide discrimination and suggest this residue is in the active site of PDE4.	Aspartic Acid	29-42	phosphodiesterase 4A	Homo sapiens	165-169
10756197-6	2000	We demonstrate that the KLF8 Pro-Val-Asp-Leu-Ser motif also contacts CtBP.	Aspartic Acid	37-40	Kruppel like factor 8	Homo sapiens	24-28
10802344-1	2000	We investigated the effects of brain-derived neurotrophic factor (BDNF) on aspartate release from cultured cerebellar neurons.	Aspartic Acid	75-84	brain derived neurotrophic factor	Homo sapiens	31-64
10802344-7	2000	The aspartate release induced by BDNF was not dependent on the extracellular Ca(2+), but required intracellular Ca(2+) mobilization.	Aspartic Acid	4-13	brain derived neurotrophic factor	Homo sapiens	33-37
10802344-1	2000	We investigated the effects of brain-derived neurotrophic factor (BDNF) on aspartate release from cultured cerebellar neurons.	Aspartic Acid	75-84	brain derived neurotrophic factor	Homo sapiens	66-70
10802344-8	2000	These results showed that BDNF may be involved in excitatory transmission using aspartate as well as glutamate through TrkB-mediated signaling in cerebellum.	Aspartic Acid	80-89	brain derived neurotrophic factor	Homo sapiens	26-30
10802344-4	2000	Aspartate release induced by BDNF was rapid and transient, as in the case of glutamate.	Aspartic Acid	0-9	brain derived neurotrophic factor	Homo sapiens	29-33
10802344-5	2000	Although high potassium evoked the release of both excitatory (glutamate and aspartate) and inhibitory (GABA and glycine) amino acid transmitters, BDNF only induced glutamate and aspartate release.	Aspartic Acid	179-188	brain derived neurotrophic factor	Homo sapiens	147-151
10802344-6	2000	BDNF-induced aspartate release was completely blocked by pretreatment with K252a or TrkB-IgG.	Aspartic Acid	13-22	brain derived neurotrophic factor	Homo sapiens	0-4
10802344-6	2000	BDNF-induced aspartate release was completely blocked by pretreatment with K252a or TrkB-IgG.	Aspartic Acid	13-22	neurotrophic receptor tyrosine kinase 2	Homo sapiens	84-88
10785511-3	2000	BSP contains an Arg-Gly-Asp (RGD) motif found in other adhesive molecules that interact with cellular integrins.	Aspartic Acid	24-27	integrin binding sialoprotein	Homo sapiens	0-3
10767346-6	2000	DNA sequence analysis revealed a C to A transversion in codon 546 in exon 14 of MDR3 in one patient, which results in the missense substitution of the wild-type alanine with an aspartic acid.	Aspartic Acid	177-190	ATP binding cassette subfamily B member 4	Homo sapiens	80-84
10788626-3	2000	In non-primate GHs, His(170) replaces the homologous Asp(171), producing a repulsive interaction with Arg(43) of the primate receptor which was believed to reduce the attraction of non-primate GH for the human GH receptor, thus providing species specificity.	Aspartic Acid	53-56	growth hormone receptor	Homo sapiens	210-221
10766853-9	2000	The caspase inhibitors carbobenzoxy-Leu-Glu-His-Asp-CH(2)F and carbobenzoxy-Asp-Glu-Val-Asp-CH(2)F, but not carbobenzoxy-Ile-Glu-Thr-Asp-CH(2)F, differentially blocked post-mitochondrial events.	Aspartic Acid	48-51	caspase 8	Rattus norvegicus	4-11
10766772-9	2000	Substitution of alanine for each of the five charged residues within the disintegrin loop of mADAM 2 revealed a critical importance for the aspartic acid at position nine.	Aspartic Acid	140-153	a disintegrin and metallopeptidase domain 2	Mus musculus	93-100
10777573-3	2000	Docking procedures suggested that A1 domain residues in strand beta3 and preceding loop (residues 559-566) as well as in helix alpha3 (residues 594-603) interact with Asp residues 272, 274, 277 and sulfated Tyr residues 278 and 279 in GP Ibalpha.	Aspartic Acid	167-170	glycoprotein Ib platelet subunit alpha	Homo sapiens	235-245
10766853-9	2000	The caspase inhibitors carbobenzoxy-Leu-Glu-His-Asp-CH(2)F and carbobenzoxy-Asp-Glu-Val-Asp-CH(2)F, but not carbobenzoxy-Ile-Glu-Thr-Asp-CH(2)F, differentially blocked post-mitochondrial events.	Aspartic Acid	76-79	caspase 8	Rattus norvegicus	4-11
10786691-9	2000	RXRalpha was found to contain two proline, glutamate/aspartate, serine, and threonine (PEST) motifs, which confer rapid turnover of many short-lived regulatory proteins that are degraded by the ubiquitin/proteasome pathway.	Aspartic Acid	53-62	retinoid X receptor alpha	Homo sapiens	0-8
10775108-2	2000	I-Ag7 lacks this aspartate and is the only class II allele expressed by the nonobese diabetic mouse.	Aspartic Acid	17-26	I-ag7	Mus musculus	0-5
10775108-5	2000	Loss of Asp(beta57) leads to an oxyanion hole in I-Ag7 that can be filled by peptide carboxyl residues or, perhaps, through interaction with the T cell receptor.	Aspartic Acid	8-11	I-ag7	Mus musculus	49-54
10764048-5	2000	Caspase-3 is a group II member (2, 3, 7) categorized by an absolute substrate requirement for aspartic acid in the P4 position of the scissile bond.	Aspartic Acid	94-107	caspase 3	Mus musculus	0-9
10744731-7	2000	In P(i) class GSTs, Tyr(154) appears to be of particular structural importance, since it interacts with conserved residues Leu(21), Asp(24), and Gln(25) of the adjacent alpha1-helix which contributes to the active site.	Aspartic Acid	132-135	glutathione S-transferase pi 1	Homo sapiens	14-18
10744740-5	2000	The primary mutations in atp1-1 and atp1-2 were identified as Thr(383) --&gt; Ile and Gly(291) --&gt; Asp, respectively.	Aspartic Acid	102-105	Atp11p	Saccharomyces cerevisiae S288C	25-31
10744740-5	2000	The primary mutations in atp1-1 and atp1-2 were identified as Thr(383) --&gt; Ile and Gly(291) --&gt; Asp, respectively.	Aspartic Acid	102-105	ATP synthase complex assembly protein ATP12	Saccharomyces cerevisiae S288C	36-42
10744740-8	2000	An unlinked suppressor gene, ASC1 (alpha-subunit complementing) of the atp1-2 mutation (Gly(291) --&gt; Asp) restored the growth defect phenotype on glycerol, but did not suppress either atp1-1 or the deletion mutant Deltaatp1.	Aspartic Acid	104-107	guanine nucleotide-binding protein subunit beta	Saccharomyces cerevisiae S288C	29-33
10744740-8	2000	An unlinked suppressor gene, ASC1 (alpha-subunit complementing) of the atp1-2 mutation (Gly(291) --&gt; Asp) restored the growth defect phenotype on glycerol, but did not suppress either atp1-1 or the deletion mutant Deltaatp1.	Aspartic Acid	104-107	F1F0 ATP synthase subunit beta	Saccharomyces cerevisiae S288C	71-77
10766139-5	2000	CONCLUSION: Administration of endothelin-1 to the microvasculature of the optic nerve leads to elevation of glutamate, aspartate, and glycine concentrations in the vitreous.	Aspartic Acid	119-128	endothelin-1	Oryctolagus cuniculus	30-42
10753663-0	2000	Two acidic amino acid residues, Asp(470) and Glu(471), contained in the carboxyl cytoplasmic tail of a major lysosomal membrane protein, LGP85/LIMP II, are important for its accumulation in secondary lysosomes.	Aspartic Acid	32-35	scavenger receptor class B member 2	Homo sapiens	137-142
10753663-0	2000	Two acidic amino acid residues, Asp(470) and Glu(471), contained in the carboxyl cytoplasmic tail of a major lysosomal membrane protein, LGP85/LIMP II, are important for its accumulation in secondary lysosomes.	Aspartic Acid	32-35	scavenger receptor class B member 2	Homo sapiens	143-150
10744717-5	2000	By introducing a basic nitrogen in the core structure of the inhibitor, a salt bridge was formed to Asp-48 in PTP1B.	Aspartic Acid	100-103	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	110-115
10733677-5	2000	Because the EDA segment enhances the integrin binding sequence Arg, Gly, Asp (RGD), which, when present, has been shown to be critical in integrin-extracellular matrix signaling, we were particularly interested in determining whether or not EDA-containing Fn (EDA+Fn) represented the aberrantly expressed Fn in psoriasis.	Aspartic Acid	73-76	ectodysplasin A	Homo sapiens	12-15
10739955-5	2000	Amino acid number 12 of K-Ras (wild type; Gly) was changed to Ser, Arg, Cys, Asp, Ala, or Val, and the mobility shift of the greenish fluorescent bands in the SDS/urea gel was analyzed.	Aspartic Acid	77-80	KRAS proto-oncogene, GTPase	Homo sapiens	24-29
10991662-14	2000	In contrast, immature cultures expressing low GDH activity utilized glutamate at lower rates while releasing substantial amounts of aspartate and alanine into the medium.	Aspartic Acid	132-141	glutamate dehydrogenase 1	Homo sapiens	46-49
10737625-9	2000	The SOD1 mutant mice demonstrated a significant (p < 0.05) increase in basal levels of extracellular aspartate and glutamate.	Aspartic Acid	101-110	superoxide dismutase 1, soluble	Mus musculus	4-8
10737625-12	2000	This study demonstrates that in areas of no visible pathology and no loss of glutamate transporter proteins, SOD1 mutant mice have elevated extracellular fluid aspartate and glutamate levels and a decreased capacity to clear glutamate from the extracellular space.	Aspartic Acid	160-169	superoxide dismutase 1, soluble	Mus musculus	109-113
10717002-8	2000	Thus, eNOS with aspartate but not glutamate at position 298 is cleaved, resulting in the generation of N-terminal 35-kDa and C-terminal 100-kDa fragments.	Aspartic Acid	16-25	nitric oxide synthase 3	Homo sapiens	6-10
10783238-2	2000	Critical intramembraneous aspartates at residues 257 and 385 are required for the function of PS1 protein.	Aspartic Acid	26-36	presenilin 1	Homo sapiens	94-97
10783238-3	2000	Here we investigate the biological function of a naturally occurring PS1 splice variant (PS1 Deltaexon 8), which lacks the critical aspartate 257.	Aspartic Acid	132-141	presenilin 1	Homo sapiens	69-72
10783238-3	2000	Here we investigate the biological function of a naturally occurring PS1 splice variant (PS1 Deltaexon 8), which lacks the critical aspartate 257.	Aspartic Acid	132-141	presenilin 1	Homo sapiens	89-92
10783238-4	2000	Cell lines that stably express PS1 Deltaexon 8 or a PS1 protein in which aspartate residue 257 is mutated secrete significant levels of Abeta, whereas Abeta generation is severely reduced in cells transfected with PS1 containing a mutation of aspartate 385.	Aspartic Acid	73-82	presenilin 1	Homo sapiens	52-55
10783238-4	2000	Cell lines that stably express PS1 Deltaexon 8 or a PS1 protein in which aspartate residue 257 is mutated secrete significant levels of Abeta, whereas Abeta generation is severely reduced in cells transfected with PS1 containing a mutation of aspartate 385.	Aspartic Acid	73-82	amyloid beta precursor protein	Homo sapiens	136-141
10783238-4	2000	Cell lines that stably express PS1 Deltaexon 8 or a PS1 protein in which aspartate residue 257 is mutated secrete significant levels of Abeta, whereas Abeta generation is severely reduced in cells transfected with PS1 containing a mutation of aspartate 385.	Aspartic Acid	73-82	presenilin 1	Homo sapiens	52-55
10783238-4	2000	Cell lines that stably express PS1 Deltaexon 8 or a PS1 protein in which aspartate residue 257 is mutated secrete significant levels of Abeta, whereas Abeta generation is severely reduced in cells transfected with PS1 containing a mutation of aspartate 385.	Aspartic Acid	243-252	amyloid beta precursor protein	Homo sapiens	151-156
10727228-2	2000	Residue Asp-38 (pK(a) 4.57) acts as a base to abstract a proton from C-4 of the substrate to form an intermediate dienolate, which is then reprotonated on C-6.	Aspartic Acid	8-11	complement C4A (Rodgers blood group)	Homo sapiens	69-72
10727228-2	2000	Residue Asp-38 (pK(a) 4.57) acts as a base to abstract a proton from C-4 of the substrate to form an intermediate dienolate, which is then reprotonated on C-6.	Aspartic Acid	8-11	complement C6	Homo sapiens	155-158
10722666-8	2000	Site-directed mutation of positions Arg(65) of ecalectin-NT and Arg(239) of ecalectin-CT to an aspartic acid residue resulted in the loss of both lactose-binding and ECA activities.	Aspartic Acid	95-108	galectin 9	Homo sapiens	47-56
10722666-8	2000	Site-directed mutation of positions Arg(65) of ecalectin-NT and Arg(239) of ecalectin-CT to an aspartic acid residue resulted in the loss of both lactose-binding and ECA activities.	Aspartic Acid	95-108	galectin 9	Homo sapiens	76-85
10698688-0	2000	Histidine to aspartate phosphotransferase activity of nm23 proteins: phosphorylation of aldolase C on Asp-319.	Aspartic Acid	102-105	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	54-58
10698688-8	2000	The sequence around Asp-319 of aldolase C has some similarities to those around the histidine residues on ATP-citrate lyase and succinic thiokinase that are phosphorylated by nm23 proteins.	Aspartic Acid	20-23	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	175-179
10694385-7	2000	Here we report that tripeptide inhibitors derived from the transframe region of Gag-Pol (Glu-Asp-Leu and Glu-Asp-Phe) bind to the HIV-1 protease with a favorable enthalpy change.	Aspartic Acid	93-96	Gag-Pol	Human immunodeficiency virus 1	80-87
10694385-7	2000	Here we report that tripeptide inhibitors derived from the transframe region of Gag-Pol (Glu-Asp-Leu and Glu-Asp-Phe) bind to the HIV-1 protease with a favorable enthalpy change.	Aspartic Acid	109-112	Gag-Pol	Human immunodeficiency virus 1	80-87
10733886-2	2000	We have cloned the human cDNA Fhit in the pPROEX-1 vector and expressed with high yield in Escherichia coli with the sequence Met-Gly-His(6)-Asp-Tyr-Asp-Ile-Pro-Thr-Thr followed by a rTEV protease cleavage site, denoted as "H6TV," fused to the N-terminus of Fhit.	Aspartic Acid	141-144	fragile histidine triad diadenosine triphosphatase	Homo sapiens	30-34
10733886-2	2000	We have cloned the human cDNA Fhit in the pPROEX-1 vector and expressed with high yield in Escherichia coli with the sequence Met-Gly-His(6)-Asp-Tyr-Asp-Ile-Pro-Thr-Thr followed by a rTEV protease cleavage site, denoted as "H6TV," fused to the N-terminus of Fhit.	Aspartic Acid	149-152	fragile histidine triad diadenosine triphosphatase	Homo sapiens	30-34
10745077-2	2000	The breakdown of cellular proteins in apoptosis is mediated by caspases, which comprise a highly conserved family of cysteine proteases with specificity for aspartic acid residues at the P1 positions of their substrates.	Aspartic Acid	157-170	caspase 1	Homo sapiens	63-71
10715115-4	2000	The distances between the functional groups of Asp 71, His 98, His 19, and the carboxylate oxygens of the 2PG molecule in MGS are similar to the corresponding distances between the functional groups of Glu 165, His 95, Lys 13, and the carboxylate oxygens of the 2PG molecule in TIM.	Aspartic Acid	47-50	triosephosphate isomerase 1	Homo sapiens	278-281
10715115-6	2000	Consistent with the known stereochemical data, the catalytic base Asp 71 is positioned on the opposite face of the 2PG-carboxylate plane as Glu 165 of TIM.	Aspartic Acid	66-69	triosephosphate isomerase 1	Homo sapiens	151-154
10717002-0	2000	Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298.	Aspartic Acid	166-175	nitric oxide synthase 3	Homo sapiens	28-61
10717002-1	2000	An endothelial nitric oxide synthase (eNOS) polymorphism in exon 7 (894 G/T) resulting in glutamate or aspartate, respectively, at position 298 on the protein is correlated with severity of cardiopulmonary diseases.	Aspartic Acid	103-112	nitric oxide synthase 3	Homo sapiens	3-36
10717002-1	2000	An endothelial nitric oxide synthase (eNOS) polymorphism in exon 7 (894 G/T) resulting in glutamate or aspartate, respectively, at position 298 on the protein is correlated with severity of cardiopulmonary diseases.	Aspartic Acid	103-112	nitric oxide synthase 3	Homo sapiens	38-42
10717002-3	2000	We now show in transfected cells, primary human endothelial cells, and human hearts, that eNOS with aspartate, but not glutamate, at position 298 is cleaved, resulting in the generation of 100-kDa and 35-kDa products.	Aspartic Acid	100-109	nitric oxide synthase 3	Homo sapiens	90-94
10692402-7	2000	These results suggest that a negative charge imposed at serine 1179, either by phosphorylation or by replacement with aspartate, increases eNOS catalytic activity by increasing electron flux at the reductase domain and by reducing calmodulin dissociation from activated eNOS when calcium levels are low.	Aspartic Acid	118-127	nitric oxide synthase 3	Bos taurus	139-143
10702277-7	2000	In addition, binding of OBA to the active site of PTP1B creates a unique arrangement involving Asp(181), Lys(120), and Tyr(46).	Aspartic Acid	95-98	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	50-55
10708865-4	2000	The primary specificity for Asp turns out to be very rare among proteases, and currently the only other known mammalian proteases with the same primary specificity is the physiological caspase activator granzyme B.	Aspartic Acid	28-31	granzyme B	Homo sapiens	203-213
10692402-2	2000	Mutation of this residue to the negatively charged aspartate (S1179D eNOS) increases nitric oxide (NO) production constitutively, in the absence of agonist challenge.	Aspartic Acid	51-60	nitric oxide synthase 3	Bos taurus	69-73
10692402-3	2000	Here, we examine the potential mechanism of how aspartate at 1179 increases eNOS activity using purified proteins.	Aspartic Acid	48-57	nitric oxide synthase 3	Bos taurus	76-80
10692402-7	2000	These results suggest that a negative charge imposed at serine 1179, either by phosphorylation or by replacement with aspartate, increases eNOS catalytic activity by increasing electron flux at the reductase domain and by reducing calmodulin dissociation from activated eNOS when calcium levels are low.	Aspartic Acid	118-127	calmodulin	Bos taurus	231-241
10692402-7	2000	These results suggest that a negative charge imposed at serine 1179, either by phosphorylation or by replacement with aspartate, increases eNOS catalytic activity by increasing electron flux at the reductase domain and by reducing calmodulin dissociation from activated eNOS when calcium levels are low.	Aspartic Acid	118-127	nitric oxide synthase 3	Bos taurus	270-274
10718838-10	2000	We found a hitherto unreported G --&gt; A transition at the second nucleotide of codon 85 in exon 1 (GGC --&gt; GAC), substituting glycine for aspartic acid (G85D).	Aspartic Acid	143-156	gamma-glutamylcyclotransferase	Homo sapiens	101-104
10884719-7	2000	Half of the extra NH3 removed by the liver was, apparently, utilized by periportal glutamate dehydrogenase and aspartate aminotransferase for sequential glutamate and aspartate synthesis and converted to urea as the 2-amino moiety of aspartate.	Aspartic Acid	167-176	aspartate aminotransferase, mitochondrial	Ovis aries	111-137
18944613-9	2000	The amino acid positions 73, 102, 109, and 149 of the CP gene, where lysine, serine, arginine, and aspartic acid reside, respectively, were uniquely conserved for genotype I Taiwan isolates.	Aspartic Acid	99-112	golgi phosphoprotein 3	Homo sapiens	54-56
10699284-1	2000	In recent years, major progress has been made in the design and synthesis of fibrinogen antagonists, which are peptidomimetic Arg-Gly-Asp (RGD) analogs.	Aspartic Acid	134-137	fibrinogen beta chain	Homo sapiens	77-87
10783466-4	2000	In recent years, more and more laboratory proof has accumulated that acupuncture can change the charge and potential of neurons, the concentrations of K(+), Na(+), Ca(++) and the content of neuro-transmitters such as aspartate, and taurine and the quantities of neuro-peptides such as beta-endorphin and leu-enkephalin.	Aspartic Acid	217-226	proopiomelanocortin	Homo sapiens	285-299
10783466-4	2000	In recent years, more and more laboratory proof has accumulated that acupuncture can change the charge and potential of neurons, the concentrations of K(+), Na(+), Ca(++) and the content of neuro-transmitters such as aspartate, and taurine and the quantities of neuro-peptides such as beta-endorphin and leu-enkephalin.	Aspartic Acid	217-226	prodynorphin	Homo sapiens	304-318
10692489-2	2000	Alanine mutation, in the human ORL1 receptor, of transmembrane amino acid residues that are conserved in opioid receptors, Asp(130) and Tyr(131) in transmembrane segment (TM) III, Phe(220) and Phe(224) in TM V, and Trp(276) in TM VI, yields mutant receptors with reduced affinity, and proportionally decreased reactivity, toward nociceptin.	Aspartic Acid	123-126	opioid related nociceptin receptor 1	Homo sapiens	31-35
10692489-2	2000	Alanine mutation, in the human ORL1 receptor, of transmembrane amino acid residues that are conserved in opioid receptors, Asp(130) and Tyr(131) in transmembrane segment (TM) III, Phe(220) and Phe(224) in TM V, and Trp(276) in TM VI, yields mutant receptors with reduced affinity, and proportionally decreased reactivity, toward nociceptin.	Aspartic Acid	123-126	prepronociceptin	Homo sapiens	329-339
10788533-6	2000	Of the p53 functional mutations, a substitution of Gly at amino acid residue 245 to Asp (G245D) was identified in two patients in three subclones.	Aspartic Acid	84-87	tumor protein p53	Homo sapiens	7-10
10712595-3	2000	Due to a single nucleotide replacement, Asn135 of the antithrombin in higher vertebrates is substituted by Asp in the salmon homolog.	Aspartic Acid	107-110	serpin family C member 1	Homo sapiens	54-66
10720073-2	2000	To assess their importance in determining the different functional specificities, we substituted aldosterone synthase-specific (aspartate D147, isoleucine I248, glutamine Q43, and threonine T493) with 11beta-hydroxylase-specific amino acids (glutamate E147, threonine T248, arginine R43, and methionine M493), respectively.	Aspartic Acid	128-137	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	97-117
10750109-3	2000	The isolated mucin had a high concentration of glutamic and aspartic acids, threonine, and serine (13.2, 11.2, 9.6, and 9.2 mol % of total amino acids assayed, respectively).	Aspartic Acid	60-74	mucin 1, cell surface associated	Bos taurus	13-18
10677220-1	2000	The Ogg1 protein of Saccharomyces cerevisiae belongs to a family of DNA glycosylases and apurinic/apyrimidinic site (AP) lyases, the signature of which is the alpha-helix-hairpin-alpha-helix-Gly/Pro-Asp (HhH-GPD) active site motif together with a conserved catalytic lysine residue, to which we refer as the HhH-GPD/K family.	Aspartic Acid	199-202	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	4-8
10692572-3	2000	Here we show that TRAF1 is cleaved after Asp-163 when cells are induced to undergo apoptosis by Fas ligand (FasL).	Aspartic Acid	41-44	TNF receptor associated factor 1	Homo sapiens	18-23
10692572-3	2000	Here we show that TRAF1 is cleaved after Asp-163 when cells are induced to undergo apoptosis by Fas ligand (FasL).	Aspartic Acid	41-44	Fas ligand	Homo sapiens	96-106
10692572-3	2000	Here we show that TRAF1 is cleaved after Asp-163 when cells are induced to undergo apoptosis by Fas ligand (FasL).	Aspartic Acid	41-44	Fas ligand	Homo sapiens	108-112
10702794-8	2000	Tyrosine phosphorylated ERK2, but not ERK1, p38, or JNK1, efficiently bound to catalytically inactive HePTP mutants in which the active site cysteine (HePTP-C/S) or the conserved aspartic acid residue (HePTP-D/A) had been exchanged for serine and alanine, respectively.	Aspartic Acid	179-192	mitogen-activated protein kinase 1	Homo sapiens	24-28
10704415-7	2000	As dEAAT2 is the first known EAAT to show this substrate selectivity, it suggests that aspartate may play a specific role in the Drosophila nervous system.	Aspartic Acid	87-96	Excitatory amino acid transporter 2	Drosophila melanogaster	3-9
10704415-7	2000	As dEAAT2 is the first known EAAT to show this substrate selectivity, it suggests that aspartate may play a specific role in the Drosophila nervous system.	Aspartic Acid	87-96	Excitatory amino acid transporter 1	Drosophila melanogaster	4-8
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Aspartic Acid	154-157	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	77-82
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Aspartic Acid	154-157	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	94-99
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Aspartic Acid	190-193	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	77-82
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Aspartic Acid	190-193	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	94-99
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Aspartic Acid	190-193	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	77-82
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Aspartic Acid	190-193	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	94-99
10660557-5	2000	For example, when the HAV motif is flanked by a single aspartic acid, which mimics the natural HAVD sequence of N-cadherin, the peptide becomes a much more effective inhibitor of N-cadherin function.	Aspartic Acid	55-68	cadherin 2	Homo sapiens	112-122
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Aspartic Acid	190-193	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	77-82
10671535-3	2000	Amino acid sequence alignment of the 2-enoyl-CoA hydratase 2 domain in human MFE-2 with other MFE-2s reveals conserved protic residues: Tyr-347, Glu-366, Asp-370, His-406, Glu-408, Tyr-410, Asp-490, Tyr-505, Asp-510, His-515, Asp-517, and His-532.	Aspartic Acid	190-193	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	94-99
10671535-9	2000	The data show that the hydratase 2 reaction catalyzed by MFE-2 requires two protic residues, Glu-366 and Asp-510, suggesting that their catalytic role may be equivalent to that of the two catalytic residues of hydratase 1.	Aspartic Acid	105-108	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	57-62
10677483-9	2000	Alignment of cleavage site sequences of peptides indicates that the specificity of memapsin 2 resides mainly at the S(1)" subsite, which prefers small side chains such as Ala, Ser, and Asp.	Aspartic Acid	185-188	beta-secretase 1	Homo sapiens	83-93
10677492-5	2000	This analysis indicated that when single amino acid residues in a region close to the luminal face of the putative transmembrane domain of Ost4p were changed into an ionizable amino acid such as Lys or Asp, growth at 37 degrees C and OT activity measured in vitro were impaired.	Aspartic Acid	202-205	olichyl-diphosphooligosaccharide--protein glycotransferase OST4	Saccharomyces cerevisiae S288C	139-144
10660541-0	2000	The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III.	Aspartic Acid	4-7	glycoprotein Ib platelet subunit alpha	Homo sapiens	41-61
10660541-0	2000	The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III.	Aspartic Acid	4-7	coagulation factor II, thrombin	Homo sapiens	111-119
10660595-0	2000	Mutation of a unique aspartate residue abolishes the catalytic activity but not substrate binding of the mouse N-methylpurine-DNA glycosylase (MPG).	Aspartic Acid	21-30	N-methylpurine-DNA glycosylase	Mus musculus	111-141
10660541-0	2000	The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III.	Aspartic Acid	4-7	serpin family C member 1	Homo sapiens	185-201
10660557-5	2000	For example, when the HAV motif is flanked by a single aspartic acid, which mimics the natural HAVD sequence of N-cadherin, the peptide becomes a much more effective inhibitor of N-cadherin function.	Aspartic Acid	55-68	cadherin 2	Homo sapiens	179-189
10660541-13	2000	Neither alpha- nor gamma(T)-thrombin bound to GpIbalpha(1-271), suggesting that the Asp(272)-Glu(282) region of GpIbalpha may act as a "heparin-like" ligand for the thrombin HBS, thereby inhibiting heparin binding to thrombin.	Aspartic Acid	84-87	glycoprotein Ib platelet subunit alpha	Homo sapiens	112-121
10660595-0	2000	Mutation of a unique aspartate residue abolishes the catalytic activity but not substrate binding of the mouse N-methylpurine-DNA glycosylase (MPG).	Aspartic Acid	21-30	N-methylpurine-DNA glycosylase	Mus musculus	143-146
10660595-2	2000	Although Asp was identified as the active site residue in various DNA glycosylases based on the crystal structure, Glu-125 in human MPG (Glu-145 in mouse MPG) was recently proposed to be the catalytic residue.	Aspartic Acid	9-12	N-methylpurine DNA glycosylase	Homo sapiens	132-135
10660595-2	2000	Although Asp was identified as the active site residue in various DNA glycosylases based on the crystal structure, Glu-125 in human MPG (Glu-145 in mouse MPG) was recently proposed to be the catalytic residue.	Aspartic Acid	9-12	N-methylpurine-DNA glycosylase	Mus musculus	154-157
10660595-3	2000	Mutational analysis for all Asp residues in a truncated, fully active MPG protein showed that only Asp-152 (Asp-132 in the human protein), which is located near the active site, is essential for catalytic activity.	Aspartic Acid	28-31	N-methylpurine DNA glycosylase	Homo sapiens	70-73
10652295-2	2000	The transition of rhodopsin from the inactive to the active state is associated with proton uptake at Glu(134) (1), and recent mutagenesis studies suggest that protonation of the homologous amino acid in the alpha(1B) adrenergic receptor (Asp(142)) may be involved in its mechanism of activation (2).	Aspartic Acid	239-242	rhodopsin	Homo sapiens	18-27
10652295-2	2000	The transition of rhodopsin from the inactive to the active state is associated with proton uptake at Glu(134) (1), and recent mutagenesis studies suggest that protonation of the homologous amino acid in the alpha(1B) adrenergic receptor (Asp(142)) may be involved in its mechanism of activation (2).	Aspartic Acid	239-242	adrenoceptor alpha 1B	Homo sapiens	208-237
10652295-7	2000	In addition, we found that the pH sensitivity of beta(2)AR activation is not abrogated by mutation of Asp(130), which is homologous to the highly conserved acidic amino acids that link protonation to activation of rhodopsin (Glu(134)) and the alpha(1B) adrenergic receptor (Asp(142)).	Aspartic Acid	274-277	adrenoceptor beta 2	Homo sapiens	49-58
10652317-9	2000	The three-dimensional structure of ligand-free hGSTM2-2 determined by x-ray crystallography suggests that Arg(107) maintains an electrostatic interaction with the Asp(161) side chain (3 A apart), but is distant from the GSH-binding site.	Aspartic Acid	163-166	glutathione S-transferase mu 2	Homo sapiens	47-55
10666057-7	2000	Conversely, expression of either a dominant-negative c-Myb basic domain mutant (Cys(43) --&gt; Asp) or a c-Myb antisense RNA blocked transcription from the -724 alpha-SMA/LUC or -271 alpha-SMA/LUC in activated cells.	Aspartic Acid	95-98	actin gamma 2, smooth muscle	Rattus norvegicus	161-170
10672029-10	2000	P1" Pro, Asp, Lys and Gly slowed the hydrolysis rates of the tomato LAP-A, porcine LAP, and E. coli PepA markedly.	Aspartic Acid	9-12	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	68-73
10672029-10	2000	P1" Pro, Asp, Lys and Gly slowed the hydrolysis rates of the tomato LAP-A, porcine LAP, and E. coli PepA markedly.	Aspartic Acid	9-12	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	68-71
10767822-2	2000	We have recently shown that in a Danish and a Czech family with a clinical syndrome similar to FAF, including corneal lattice dystrophy, cranial neuropathy and skin changes, the disease is caused by another mutation at the same position, namely 654G-T predicting a Try-for-Asp substitution at 187 in secreted gelsolin.	Aspartic Acid	273-276	gelsolin	Homo sapiens	309-317
10767822-6	2000	Compared with the wild-type gelsolin peptide (Asp-187), the corresponding mutant peptide (Tyr-187) showed dramatically increased fibrillogenicity as revealed by quantitative thioflavine-T based fluorimetry; ultrastructurally, amyloid-like fibrils were formed by the mutant peptide.	Aspartic Acid	46-49	gelsolin	Homo sapiens	28-36
10660541-15	2000	Altogether, these findings show that thrombin HBS binds to the region of GpIbalpha involving the Asp(272)-Glu(282) segment, protecting the enzyme from the inactivation by the heparin-AT system.	Aspartic Acid	97-100	coagulation factor II, thrombin	Homo sapiens	37-45
10660541-15	2000	Altogether, these findings show that thrombin HBS binds to the region of GpIbalpha involving the Asp(272)-Glu(282) segment, protecting the enzyme from the inactivation by the heparin-AT system.	Aspartic Acid	97-100	glycoprotein Ib platelet subunit alpha	Homo sapiens	73-82
10660595-3	2000	Mutational analysis for all Asp residues in a truncated, fully active MPG protein showed that only Asp-152 (Asp-132 in the human protein), which is located near the active site, is essential for catalytic activity.	Aspartic Acid	99-102	N-methylpurine DNA glycosylase	Homo sapiens	70-73
10660595-3	2000	Mutational analysis for all Asp residues in a truncated, fully active MPG protein showed that only Asp-152 (Asp-132 in the human protein), which is located near the active site, is essential for catalytic activity.	Aspartic Acid	99-102	N-methylpurine DNA glycosylase	Homo sapiens	70-73
10660595-6	2000	We propose that in addition to Glu-145 in mouse MPG, which functions as the activator of a water molecule for nucleophilic attack, Asp-152 plays an essential role either by donating a proton to the substrate base and, thus, facilitating its release or by stabilizing the steric configuration of the active site pocket.	Aspartic Acid	131-134	N-methylpurine-DNA glycosylase	Mus musculus	48-51
10652302-0	2000	The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.	Aspartic Acid	18-28	presenilin 1	Homo sapiens	32-50
10652302-2	2000	Recently, we found that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS1 either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase.	Aspartic Acid	57-67	presenilin 1	Homo sapiens	71-74
10652302-2	2000	Recently, we found that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS1 either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase.	Aspartic Acid	57-67	amyloid beta precursor protein	Homo sapiens	92-97
10652302-2	2000	Recently, we found that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS1 either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase.	Aspartic Acid	57-67	presenilin 1	Homo sapiens	134-137
10652302-4	2000	Here, we show that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1.	Aspartic Acid	30-40	presenilin 2	Homo sapiens	44-47
10652302-4	2000	Here, we show that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1.	Aspartic Acid	30-40	presenilin 2	Homo sapiens	128-131
10652302-4	2000	Here, we show that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1.	Aspartic Acid	30-40	presenilin 1	Homo sapiens	162-165
10652302-5	2000	Cells stably co-expressing TM Asp --&gt; Ala mutations in both PS1 and PS2 show further accumulation of the APP-derived gamma-secretase substrates, C83 and C99.	Aspartic Acid	30-33	presenilin 1	Homo sapiens	63-66
10652302-5	2000	Cells stably co-expressing TM Asp --&gt; Ala mutations in both PS1 and PS2 show further accumulation of the APP-derived gamma-secretase substrates, C83 and C99.	Aspartic Acid	30-33	presenilin 2	Homo sapiens	71-74
10652302-7	2000	Furthermore, endoproteolysis of the exogenous Asp mutant PS2 is absent, and endogenous PS1 C-terminal fragments are diminished to undetectable levels.	Aspartic Acid	46-49	presenilin 2	Homo sapiens	57-60
10652302-10	2000	We conclude that presenilins, and their TM aspartates in particular, are attractive targets for lowering Abeta therapeutically to prevent Alzheimer"s disease.	Aspartic Acid	43-53	amyloid beta precursor protein	Homo sapiens	105-110
10666143-2	2000	Aminopeptidase-A (APA) is an ectoenzyme that selectively hydrolyzes acidic residues from the amino terminus of oligopeptides, including biologically active [Asp(1)]ANG II and [Asp(1)]CCK-8.	Aspartic Acid	157-160	glutamyl aminopeptidase	Rattus norvegicus	0-16
10666143-2	2000	Aminopeptidase-A (APA) is an ectoenzyme that selectively hydrolyzes acidic residues from the amino terminus of oligopeptides, including biologically active [Asp(1)]ANG II and [Asp(1)]CCK-8.	Aspartic Acid	157-160	glutamyl aminopeptidase	Rattus norvegicus	18-21
10666143-2	2000	Aminopeptidase-A (APA) is an ectoenzyme that selectively hydrolyzes acidic residues from the amino terminus of oligopeptides, including biologically active [Asp(1)]ANG II and [Asp(1)]CCK-8.	Aspartic Acid	157-160	angiotensinogen	Rattus norvegicus	164-170
10666143-2	2000	Aminopeptidase-A (APA) is an ectoenzyme that selectively hydrolyzes acidic residues from the amino terminus of oligopeptides, including biologically active [Asp(1)]ANG II and [Asp(1)]CCK-8.	Aspartic Acid	176-179	glutamyl aminopeptidase	Rattus norvegicus	0-16
10666143-2	2000	Aminopeptidase-A (APA) is an ectoenzyme that selectively hydrolyzes acidic residues from the amino terminus of oligopeptides, including biologically active [Asp(1)]ANG II and [Asp(1)]CCK-8.	Aspartic Acid	176-179	glutamyl aminopeptidase	Rattus norvegicus	18-21
10642505-2	2000	The human type I collagen sequence A(1209)HDGGR(1214) of CTx can undergo racemization of the aspartic acid residue Asp(1211) and isomerization of the bond between this residue and Gly(1212).	Aspartic Acid	93-106	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	57-60
10642505-2	2000	The human type I collagen sequence A(1209)HDGGR(1214) of CTx can undergo racemization of the aspartic acid residue Asp(1211) and isomerization of the bond between this residue and Gly(1212).	Aspartic Acid	115-118	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	57-60
10691848-0	2000	Defective fibrinogen polymerization associated with a novel gamma279Ala-->Asp mutation.	Aspartic Acid	74-77	fibrinogen beta chain	Homo sapiens	10-20
10664521-6	2000	Analysis of germline DNA in the proband showed a missense mutation (GGC--&gt;GAC) at codon 305 in exon 7 of the MEN1 gene that predicts an amino acid change from glycine to aspartic acid (G305D).	Aspartic Acid	173-186	gamma-glutamylcyclotransferase	Homo sapiens	68-71
10664521-6	2000	Analysis of germline DNA in the proband showed a missense mutation (GGC--&gt;GAC) at codon 305 in exon 7 of the MEN1 gene that predicts an amino acid change from glycine to aspartic acid (G305D).	Aspartic Acid	173-186	menin 1	Homo sapiens	112-116
10706475-2	2000	DPP is extremely acidic and is rich in aspartic acid and serine.	Aspartic Acid	39-52	dentin sialophosphoprotein	Homo sapiens	0-3
10731697-6	2000	The full-length recombinant calpastatin was also cleaved by caspase-3 or caspase-7 at Asp-233 into the same size fragment.	Aspartic Acid	86-89	caspase 3	Homo sapiens	60-69
10731697-6	2000	The full-length recombinant calpastatin was also cleaved by caspase-3 or caspase-7 at Asp-233 into the same size fragment.	Aspartic Acid	86-89	caspase 7	Homo sapiens	73-82
10648631-0	2000	Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.	Aspartic Acid	68-71	adrenoceptor alpha 1B	Homo sapiens	93-122
10646529-11	2000	In summary, both aspartate and glutamate showed greater clearances from CSF in the adult than the neonate.	Aspartic Acid	17-26	colony stimulating factor 2	Rattus norvegicus	72-75
10656678-4	2000	The resultant amino acid substitution from aspartate to glycine may have vital implication in PCNA mediated cell cycle regulation by p21(waf1/cip1).	Aspartic Acid	43-52	proliferating cell nuclear antigen	Homo sapiens	94-98
10644696-8	2000	This marked difference in substrate specificity between DYRK1A and ERK2 can be explained by the requirement for an arginine at the P -3 site of DYRK substrates and its presumed interaction with aspartate 247 conserved in all DYRKs.	Aspartic Acid	194-203	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	56-62
10644696-8	2000	This marked difference in substrate specificity between DYRK1A and ERK2 can be explained by the requirement for an arginine at the P -3 site of DYRK substrates and its presumed interaction with aspartate 247 conserved in all DYRKs.	Aspartic Acid	194-203	mitogen-activated protein kinase 1	Homo sapiens	67-71
10644696-8	2000	This marked difference in substrate specificity between DYRK1A and ERK2 can be explained by the requirement for an arginine at the P -3 site of DYRK substrates and its presumed interaction with aspartate 247 conserved in all DYRKs.	Aspartic Acid	194-203	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	56-60
10813966-3	2000	The key process involves an efficient synthesis of the C-2 side chain (R)-4-mercaptopyrrolidine-2-thione 2 from L-aspartic acid and the construction of the 1-beta-methylcarbapenem skeleton.	Aspartic Acid	112-127	complement C2	Homo sapiens	55-58
10655591-5	2000	Two aspartic acids in this domain are essential for docking, one of which is mutated in the sevenmaker mutant of Drosophila ERK/Rolled.	Aspartic Acid	4-18	rolled	Drosophila melanogaster	124-127
10666514-1	2000	The conserved aspartic acid that is required for ligand binding to the dopamine D(2) receptor is followed by three tandem sulfur-containing amino acids.	Aspartic Acid	14-27	dopamine receptor D2	Homo sapiens	71-93
10636859-8	2000	Full phosphorylation and desensitization of C5aR were obtained when these serines were replaced by aspartic acid residues.	Aspartic Acid	99-112	complement C5a receptor 1	Homo sapiens	44-48
10656678-4	2000	The resultant amino acid substitution from aspartate to glycine may have vital implication in PCNA mediated cell cycle regulation by p21(waf1/cip1).	Aspartic Acid	43-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	133-146
10625675-6	2000	Mutation of both of these amino acids to the corresponding amino acids in 15-LOX-2 (Asp and Val, respectively) converted the positional specificity from 8S to 90% 15S without yielding any other by-products.	Aspartic Acid	84-87	arachidonate 15-lipoxygenase type B	Homo sapiens	74-82
10625485-2	2000	The mechanism involves sequential enolization and ketonization, with Asp-38 acting to transfer a proton from C-4 to C-6 through a dienol(ate) intermediate.	Aspartic Acid	69-72	complement C4A (Rodgers blood group)	Homo sapiens	109-112
10625634-1	2000	Osteopontin (OPN) is a sialic acid-rich, adhesive, extracellular matrix (ECM) protein with Arg-Gly-Asp cell-binding sequence that interacts with several integrins, including alpha(v)beta(3).	Aspartic Acid	99-102	secreted phosphoprotein 1	Mus musculus	0-11
10625634-1	2000	Osteopontin (OPN) is a sialic acid-rich, adhesive, extracellular matrix (ECM) protein with Arg-Gly-Asp cell-binding sequence that interacts with several integrins, including alpha(v)beta(3).	Aspartic Acid	99-102	secreted phosphoprotein 1	Mus musculus	13-16
10625675-10	2000	Enzymes that react with substrate "head first" (5-LOX and 8-LOX) have a bulky aromatic amino acid and a histidine in these positions, whereas lipoxygenases that accept substrates "tail first" (12-LOX and 15-LOX) have an aliphatic residue with a glutamine or aspartate.	Aspartic Acid	258-267	arachidonate 5-lipoxygenase	Homo sapiens	48-53
10625675-10	2000	Enzymes that react with substrate "head first" (5-LOX and 8-LOX) have a bulky aromatic amino acid and a histidine in these positions, whereas lipoxygenases that accept substrates "tail first" (12-LOX and 15-LOX) have an aliphatic residue with a glutamine or aspartate.	Aspartic Acid	258-267	arachidonate 8-lipoxygenase	Mus musculus	58-63
10625675-10	2000	Enzymes that react with substrate "head first" (5-LOX and 8-LOX) have a bulky aromatic amino acid and a histidine in these positions, whereas lipoxygenases that accept substrates "tail first" (12-LOX and 15-LOX) have an aliphatic residue with a glutamine or aspartate.	Aspartic Acid	258-267	arachidonate 15-lipoxygenase	Homo sapiens	193-199
10639099-13	2000	Site-directed mutagenesis of the GlyR alpha1 subunit identified aspartate 80 and threonine 112 as important determinants of Zn2+ potentiation and inhibition, respectively, without affecting potentiation by ethanol.	Aspartic Acid	64-73	glycine receptor alpha 1	Homo sapiens	33-44
10625485-2	2000	The mechanism involves sequential enolization and ketonization, with Asp-38 acting to transfer a proton from C-4 to C-6 through a dienol(ate) intermediate.	Aspartic Acid	69-72	complement C6	Homo sapiens	116-119
10606764-8	2000	This is in contrast to the suggestion based on mutagenesis studies that an interaction between the 3"-hydroxyl group of the flavin and the beta-carbonyl of Asp(227) is required for the covalent flavinylation reaction of MAO B (Zhou et al., J. Biol.	Aspartic Acid	156-159	monoamine oxidase B	Homo sapiens	220-225
10982176-7	2000	However, ETDT did reveal significant association/linkage with the marker D11S987 (P=0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.	Aspartic Acid	129-132	IDDM4	Homo sapiens	103-108
11193762-6	2000	In the known uteroglobin structures, this lysine forms an exposed salt bridge with an aspartate side chain, which is conserved in almost all sequences.	Aspartic Acid	86-95	secretoglobin family 1A member 1	Homo sapiens	13-24
10892540-7	2000	The insertion of two negatively charged (Asp) residues into a Trp4-tag enhanced the partition towards the PEG phase even more.	Aspartic Acid	41-44	transient receptor potential cation channel subfamily C member 4	Homo sapiens	62-66
11261807-0	2000	Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-32	presenilin 1	Homo sapiens	54-66
11261807-0	2000	Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-32	presenilin 2	Homo sapiens	71-83
11261807-5	2000	Aspartate-mutant presenilin holoproteins also preclude entry of endogenous wild-type PS1/PS2 into the high molecular weight complexes, but do not affect the incorporation of wild-type holoproteins into lower molecular weight holoprotein complexes.	Aspartic Acid	0-9	presenilin 1	Homo sapiens	85-88
11261807-5	2000	Aspartate-mutant presenilin holoproteins also preclude entry of endogenous wild-type PS1/PS2 into the high molecular weight complexes, but do not affect the incorporation of wild-type holoproteins into lower molecular weight holoprotein complexes.	Aspartic Acid	0-9	presenilin 2	Homo sapiens	89-92
11193155-7	2000	Given that it has been recently shown that PS1 mutations of aspartate 257 or 385 result in prevention of PS1 endoproteolysis and inhibition of gamma-secretase activity, we also tested whether PS1 endoproteolysis is required for beta-catenin/GSK3 beta/PS1 binding and whether PS1 FAD-linked mutations affect GSK3 beta recruitment in the PS1/beta-catenin complex.	Aspartic Acid	60-69	presenilin 1	Mus musculus	43-46
11193155-7	2000	Given that it has been recently shown that PS1 mutations of aspartate 257 or 385 result in prevention of PS1 endoproteolysis and inhibition of gamma-secretase activity, we also tested whether PS1 endoproteolysis is required for beta-catenin/GSK3 beta/PS1 binding and whether PS1 FAD-linked mutations affect GSK3 beta recruitment in the PS1/beta-catenin complex.	Aspartic Acid	60-69	presenilin 1	Mus musculus	105-108
11193155-7	2000	Given that it has been recently shown that PS1 mutations of aspartate 257 or 385 result in prevention of PS1 endoproteolysis and inhibition of gamma-secretase activity, we also tested whether PS1 endoproteolysis is required for beta-catenin/GSK3 beta/PS1 binding and whether PS1 FAD-linked mutations affect GSK3 beta recruitment in the PS1/beta-catenin complex.	Aspartic Acid	60-69	presenilin 1	Mus musculus	105-108
11193155-7	2000	Given that it has been recently shown that PS1 mutations of aspartate 257 or 385 result in prevention of PS1 endoproteolysis and inhibition of gamma-secretase activity, we also tested whether PS1 endoproteolysis is required for beta-catenin/GSK3 beta/PS1 binding and whether PS1 FAD-linked mutations affect GSK3 beta recruitment in the PS1/beta-catenin complex.	Aspartic Acid	60-69	presenilin 1	Mus musculus	105-108
11193155-7	2000	Given that it has been recently shown that PS1 mutations of aspartate 257 or 385 result in prevention of PS1 endoproteolysis and inhibition of gamma-secretase activity, we also tested whether PS1 endoproteolysis is required for beta-catenin/GSK3 beta/PS1 binding and whether PS1 FAD-linked mutations affect GSK3 beta recruitment in the PS1/beta-catenin complex.	Aspartic Acid	60-69	presenilin 1	Mus musculus	105-108
11193155-7	2000	Given that it has been recently shown that PS1 mutations of aspartate 257 or 385 result in prevention of PS1 endoproteolysis and inhibition of gamma-secretase activity, we also tested whether PS1 endoproteolysis is required for beta-catenin/GSK3 beta/PS1 binding and whether PS1 FAD-linked mutations affect GSK3 beta recruitment in the PS1/beta-catenin complex.	Aspartic Acid	60-69	presenilin 1	Mus musculus	105-108
11094437-3	2000	The central third complementarity-determining region (CDR3) residues of a human monoclonal anti-proteinase 3 (PR3) antibody contained many negatively charged aspartic acid residues, perhaps contributing to its reactivity with positively charged PR3 regions.	Aspartic Acid	158-171	CDR3	Homo sapiens	54-58
11094437-3	2000	The central third complementarity-determining region (CDR3) residues of a human monoclonal anti-proteinase 3 (PR3) antibody contained many negatively charged aspartic acid residues, perhaps contributing to its reactivity with positively charged PR3 regions.	Aspartic Acid	158-171	proteinase 3	Homo sapiens	96-108
11094437-3	2000	The central third complementarity-determining region (CDR3) residues of a human monoclonal anti-proteinase 3 (PR3) antibody contained many negatively charged aspartic acid residues, perhaps contributing to its reactivity with positively charged PR3 regions.	Aspartic Acid	158-171	proteinase 3	Homo sapiens	110-113
11094437-3	2000	The central third complementarity-determining region (CDR3) residues of a human monoclonal anti-proteinase 3 (PR3) antibody contained many negatively charged aspartic acid residues, perhaps contributing to its reactivity with positively charged PR3 regions.	Aspartic Acid	158-171	proteinase 3	Homo sapiens	245-248
11582573-6	2000	These results are discussed at the light on to the three-dimensional structure and the thermodynamic stability of the aspartic acid derivatives of RNase A.	Aspartic Acid	118-131	ribonuclease A family member 1, pancreatic	Homo sapiens	147-154
11044801-2	2000	CCK(4) (Trp-Met-Asp-Phe-NH(2)) has an insulinotropic effect, but is 1,000-fold less potent than CCK(8) in rodents.	Aspartic Acid	16-19	cholecystokinin	Rattus norvegicus	0-3
11211158-3	2000	The synthetic peptide Cys-Gly-(Arg-Gly-Asp)-Ser-Pro-Lys, containing the cell-adhesive region of fibronectin (RGD), has been grafted to the polymer substrate via the cysteine residue using a procedure recently developed in the authors laboratory.	Aspartic Acid	39-42	fibronectin 1	Rattus norvegicus	96-107
10620137-0	2000	A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens.	Aspartic Acid	21-34	keratin 2	Homo sapiens	68-78
10854763-0	2000	Simultaneous activation of N-methyl-D-aspartate and neurokinin-1 receptors modulates c-Fos and Zif/268 expression in the rat trigeminal nucleus caudalis.	Aspartic Acid	37-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-90
10721670-1	2000	We found a novel A--&gt;C change in codon 511 of the ARNT gene, which predicted the substitution of Asn (AAC) for Asp (GAC) at this position.	Aspartic Acid	114-117	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	53-57
10721670-1	2000	We found a novel A--&gt;C change in codon 511 of the ARNT gene, which predicted the substitution of Asn (AAC) for Asp (GAC) at this position.	Aspartic Acid	114-117	glycine-N-acyltransferase	Homo sapiens	105-108
10678172-4	2000	Based on this information, we have identified two aspartic acid residues in RAG1 (D600 and D708) that function specifically in catalysis.	Aspartic Acid	50-63	recombination activating 1	Homo sapiens	76-80
10854763-0	2000	Simultaneous activation of N-methyl-D-aspartate and neurokinin-1 receptors modulates c-Fos and Zif/268 expression in the rat trigeminal nucleus caudalis.	Aspartic Acid	37-47	early growth response 1	Rattus norvegicus	95-102
10685888-5	2000	The deduced albino chicken tyrosinase protein lacks two amino acids, aspartic acid and tryptophan.	Aspartic Acid	69-82	tyrosinase	Gallus gallus	27-37
11041354-5	2000	MSH and UVL stimulate transcription of melanogenic genes that elicit dramatic increases in the amount of eumelanins produced, whereas ASP serves as an antagonist of MSH and inhibits the transcription of those same genes.	Aspartic Acid	134-137	proopiomelanocortin	Homo sapiens	165-168
10631259-7	2000	This inhibitory sequence appears to overlap with a calmodulin-binding site in ACA2, previously mapped between aspartate-19 and arginine-36 (J.F.	Aspartic Acid	110-119	calmodulin	Saccharomyces cerevisiae S288C	51-61
11055120-7	2000	Two A--&gt;G transitions are detected, and it resulted in corresponding changes of amino acid (Asn--&gt;Asp and Glu--&gt;Gly) in the HSL protein, respectively.	Aspartic Acid	104-107	lipase E, hormone sensitive type	Sus scrofa	133-136
10631259-7	2000	This inhibitory sequence appears to overlap with a calmodulin-binding site in ACA2, previously mapped between aspartate-19 and arginine-36 (J.F.	Aspartic Acid	110-119	Cst6p	Saccharomyces cerevisiae S288C	78-82
10601249-4	1999	In CCS the fourth histidine is replaced by an aspartate (Asp(200)).	Aspartic Acid	46-55	copper chaperone for superoxide dismutase	Homo sapiens	3-6
10608874-7	1999	Cytochrome c/cytochrome c oxidase interactions of Lys(13) with Asp(119) and Lys(72) with Gln(103) and Asp(158) are the most critical polar interactions due to their proximity to the hydrophobic region and exclusion from bulk solvent.	Aspartic Acid	63-66	LOC104968582	Bos taurus	0-12
10608874-7	1999	Cytochrome c/cytochrome c oxidase interactions of Lys(13) with Asp(119) and Lys(72) with Gln(103) and Asp(158) are the most critical polar interactions due to their proximity to the hydrophobic region and exclusion from bulk solvent.	Aspartic Acid	63-66	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-33
10601249-4	1999	In CCS the fourth histidine is replaced by an aspartate (Asp(200)).	Aspartic Acid	57-60	copper chaperone for superoxide dismutase	Homo sapiens	3-6
10601249-8	1999	The aspartate at CCS position 200 is well conserved among mammalian CCS molecules, and we propose that this residue has evolved to preclude deleterious reactions involving copper bound to CCS.	Aspartic Acid	4-13	copper chaperone for superoxide dismutase	Homo sapiens	17-20
10608848-2	1999	The myopathy loop contains the TEDS residue (Asp(403)), which is a target of the heavy-chain kinase in myosin I.	Aspartic Acid	45-48	myosin heavy chain 14	Homo sapiens	103-109
10601249-8	1999	The aspartate at CCS position 200 is well conserved among mammalian CCS molecules, and we propose that this residue has evolved to preclude deleterious reactions involving copper bound to CCS.	Aspartic Acid	4-13	copper chaperone for superoxide dismutase	Homo sapiens	68-71
10601249-8	1999	The aspartate at CCS position 200 is well conserved among mammalian CCS molecules, and we propose that this residue has evolved to preclude deleterious reactions involving copper bound to CCS.	Aspartic Acid	4-13	copper chaperone for superoxide dismutase	Homo sapiens	68-71
10606725-4	1999	The Cry1Aa toxin bound to the fragment containing 40-Asp to 313-Lys, suggesting that the Cry1Aa toxin-binding site is located in the region between 40-Asp and 313-Lys, while Cry1Ac toxin bound exclusively to mature APN.	Aspartic Acid	53-56	aminopeptidase N	Bombyx mori	215-218
10637513-8	1999	Mutation of this serine to aspartate or glutamate, but not alanine, in combination with the inactivating lysine mutation restores integrin-linked kinase dependent phosphorylation of serine-473 of protein kinase B.	Aspartic Acid	27-36	integrin linked kinase	Homo sapiens	130-152
10637513-8	1999	Mutation of this serine to aspartate or glutamate, but not alanine, in combination with the inactivating lysine mutation restores integrin-linked kinase dependent phosphorylation of serine-473 of protein kinase B.	Aspartic Acid	27-36	protein tyrosine kinase 2 beta	Homo sapiens	196-212
10593990-2	1999	The activity that cleaves APP (called gamma-secretase) has properties of an aspartyl protease, and mutation of either of the two aspartate residues located in adjacent transmembrane domains of PS1 inhibits gamma-secretase processing of APP.	Aspartic Acid	129-138	presenilin 1	Homo sapiens	193-196
10593990-3	1999	We show here that these aspartates are required for Notch processing, since mutation of these residues prevents PS1 from inducing the gamma-secretase-like proteolysis of a Notch1 derivative.	Aspartic Acid	24-34	notch receptor 1	Homo sapiens	52-57
10593990-3	1999	We show here that these aspartates are required for Notch processing, since mutation of these residues prevents PS1 from inducing the gamma-secretase-like proteolysis of a Notch1 derivative.	Aspartic Acid	24-34	presenilin 1	Homo sapiens	112-115
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Aspartic Acid	170-173	hypothetical protein	Escherichia coli	0-4
10593990-3	1999	We show here that these aspartates are required for Notch processing, since mutation of these residues prevents PS1 from inducing the gamma-secretase-like proteolysis of a Notch1 derivative.	Aspartic Acid	24-34	notch receptor 1	Homo sapiens	172-178
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Aspartic Acid	170-173	arginine deiminase	Escherichia coli	148-152
10585460-0	1999	Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase.	Aspartic Acid	0-9	aldehyde dehydrogenase 1 family member L1	Homo sapiens	83-122
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Aspartic Acid	170-173	arginine deiminase	Escherichia coli	246-250
10622742-4	1999	Treatment of several aspartic acid to alanine mutants of PKCmu with caspase-3 resulted in an unexpected finding.	Aspartic Acid	21-34	protein kinase D1	Homo sapiens	57-62
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Aspartic Acid	192-195	hypothetical protein	Escherichia coli	0-4
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Aspartic Acid	192-195	arginine deiminase	Escherichia coli	148-152
10585483-4	1999	ArcB is a tripartite kinase, possessing a primary transmitter, a receiver, and a secondary transmitter domain that catalyzes the phosphorylation of ArcA via a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay, as well as the dephosphorylation of ArcA-P by a reverse phosphorelay.	Aspartic Acid	192-195	arginine deiminase	Escherichia coli	246-250
10602493-6	1999	By testing HPK1 proteins with in vivo and in vitro cleavage assays, we showed that aspartic acid residue 385 is the target for caspases.	Aspartic Acid	83-96	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	11-15
10585460-4	1999	All these enzymes have a strictly conserved aspartate, which is Asp(142) in the case of N(t)-FDH.	Aspartic Acid	44-53	aldehyde dehydrogenase 1 family member L1	Homo sapiens	88-96
10585460-4	1999	All these enzymes have a strictly conserved aspartate, which is Asp(142) in the case of N(t)-FDH.	Aspartic Acid	64-67	aldehyde dehydrogenase 1 family member L1	Homo sapiens	88-96
10585460-5	1999	Replacement of the aspartate with alanine, asparagine, glutamate, or glutamine in N(t)-FDH resulted in complete loss of hydrolase activity.	Aspartic Acid	19-28	aldehyde dehydrogenase 1 family member L1	Homo sapiens	82-90
10585460-9	1999	This study shows that Asp(142) is an essential residue in the enzyme mechanism for both the hydrolase and dehydrogenase reactions of FDH, suggesting that either the two catalytic centers of FDH are overlapped or the dehydrogenase reaction occurs within the hydrolase catalytic center.	Aspartic Acid	22-25	aldehyde dehydrogenase 1 family member L1	Homo sapiens	133-136
10585460-9	1999	This study shows that Asp(142) is an essential residue in the enzyme mechanism for both the hydrolase and dehydrogenase reactions of FDH, suggesting that either the two catalytic centers of FDH are overlapped or the dehydrogenase reaction occurs within the hydrolase catalytic center.	Aspartic Acid	22-25	aldehyde dehydrogenase 1 family member L1	Homo sapiens	190-193
10574939-8	1999	Alanine-scanning mutagenesis identified several charged and aromatic residues (Asp-2, Tyr-3, Tyr-10, Asp-11, and Glu-18) that played an important role in both chemokine and Env high affinity binding.	Aspartic Acid	79-82	endogenous retrovirus group K member 20	Homo sapiens	173-176
10622742-4	1999	Treatment of several aspartic acid to alanine mutants of PKCmu with caspase-3 resulted in an unexpected finding.	Aspartic Acid	21-34	caspase 3	Homo sapiens	68-77
10567237-1	1999	The high-affinity interaction of integrin alpha5beta1 with the central cell-binding domain of fibronectin requires both the Arg-Gly-Asp (RGD) sequence (in the tenth type III repeat) and a second site Pro-His-Ser-Arg-Asn (PHSRN) in the adjacent ninth type III repeat, which synergizes with RGD.	Aspartic Acid	132-135	fibronectin 1	Homo sapiens	94-105
10561578-4	1999	An N-glycosylation minus mutant, that was constructed by site-directed mutagenesis (by changing asparagine residues to glutamine and aspartic acid residues at positions 73 and 305 in potential N-glycosylation sites of rat CE) and expressed in normal rat kidney cells, was also purified to homogeneity from the cell extracts.	Aspartic Acid	133-146	cathepsin E	Rattus norvegicus	222-224
10654085-7	1999	Except for Dip5p, which is a transporter for Glu, Asp, Gln, Asn, Ser, Ala and Gly, the rest of the permeases exhibit narrow specificity.	Aspartic Acid	50-53	Dip5p	Saccharomyces cerevisiae S288C	11-16
10581274-2	1999	We used site-directed mutagenesis to demonstrate that both the presumptive active-site cysteine of the CED-3 protease and the aspartate residues at sites of processing of the CED-3 proprotein are required for programmed cell death in vivo.	Aspartic Acid	126-135	Cell death protein 3 subunit p17	Caenorhabditis elegans	103-108
10561456-4	1999	NEU2 encoded protein is a polypeptide of 380 amino acids with two Asp block consensuses and the YRIP sequence in the amino terminal part of the primary structure.	Aspartic Acid	66-69	neuraminidase 2	Homo sapiens	0-4
10581274-2	1999	We used site-directed mutagenesis to demonstrate that both the presumptive active-site cysteine of the CED-3 protease and the aspartate residues at sites of processing of the CED-3 proprotein are required for programmed cell death in vivo.	Aspartic Acid	126-135	Cell death protein 3 subunit p17	Caenorhabditis elegans	175-180
10567586-3	1999	In the present work, we demonstrate that replacement of Ser-128 or Thr-201 with a negatively charged aspartic acid residue (S128D or T201D) elevates Plx1 activity severalfold and that replacement of both Ser-128 and Thr-201 with Asp residues (S128D/T201D) increases Plx1 activity approximately 40-fold.	Aspartic Acid	101-114	polo like kinase 1 L homeolog	Xenopus laevis	149-153
10641865-1	1999	This study was conducted to determine whether an antimicrobially induced (ASP-250) increase in serum IGF-I was the result of differences in feed intake.	Aspartic Acid	74-77	insulin like growth factor 1	Sus scrofa	101-106
10641865-4	1999	The ASP-250 ad libitum-intake pigs had serum IGF-I concentrations that were greater (P&lt;.01) than those of their ad libitum-intake control littermates.	Aspartic Acid	4-7	insulin like growth factor 1	Sus scrofa	45-50
10641865-5	1999	Similarly, the ASP-250 limit-fed pigs had serum IGF-I concentrations that were greater (P&lt;.01) than those of the controls.	Aspartic Acid	15-18	insulin like growth factor 1	Sus scrofa	48-53
10641865-8	1999	A time course of antimicrobially induced alterations in serum IGF-I concentrations revealed that the effect of increased serum IGF-I levels in ASP-250-supplemented pigs (P&lt;.02) was observed within 4 d and was maintained throughout the 4-wk study.	Aspartic Acid	143-146	insulin like growth factor 1	Sus scrofa	62-67
10641865-8	1999	A time course of antimicrobially induced alterations in serum IGF-I concentrations revealed that the effect of increased serum IGF-I levels in ASP-250-supplemented pigs (P&lt;.02) was observed within 4 d and was maintained throughout the 4-wk study.	Aspartic Acid	143-146	insulin like growth factor 1	Sus scrofa	127-132
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Aspartic Acid	42-55	dipeptidyl peptidase 7	Homo sapiens	74-77
10635333-3	1999	In contrast, C/EBP beta-/- hepatocytes expressing the phosphorylation mimic mutants, rat C/EBP beta Asp-105 or mouse C/EBP beta Glu-217, exhibited marked proliferation in the absence of TGF alpha.	Aspartic Acid	100-103	CCAAT/enhancer binding protein beta	Rattus norvegicus	13-23
10635333-3	1999	In contrast, C/EBP beta-/- hepatocytes expressing the phosphorylation mimic mutants, rat C/EBP beta Asp-105 or mouse C/EBP beta Glu-217, exhibited marked proliferation in the absence of TGF alpha.	Aspartic Acid	100-103	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	89-99
10635333-3	1999	In contrast, C/EBP beta-/- hepatocytes expressing the phosphorylation mimic mutants, rat C/EBP beta Asp-105 or mouse C/EBP beta Glu-217, exhibited marked proliferation in the absence of TGF alpha.	Aspartic Acid	100-103	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	89-99
10613648-10	1999	These data indicate that residue Asp 318 is important for normal fibrin polymerization and the protective effect of calcium ions against plasmin degradation of the C-terminal part of the gamma-chain.	Aspartic Acid	33-36	plasminogen	Homo sapiens	137-144
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Aspartic Acid	42-55	dipeptidyl peptidase 4	Homo sapiens	209-213
10567372-8	1999	The putative active site residues serine, aspartic acid, and histidine of QPP show an ordering of the catalytic triad similar to that seen in the post-proline cleaving exopeptidases prolylcarboxypeptidase and CD26/dipeptidyl peptidase IV.	Aspartic Acid	42-55	dipeptidyl peptidase 4	Homo sapiens	214-237
10559253-1	1999	Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase.	Aspartic Acid	53-63	pleckstrin	Homo sapiens	127-130
10580153-1	1999	Protein L-isoaspartyl methyltransferase (Pimt) is a highly conserved enzyme utilising S-adenosylmethionine (AdoMet) to methylate aspartate residues of proteins damaged by age-related isomerisation and deamidation.	Aspartic Acid	129-138	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	0-39
10580153-1	1999	Protein L-isoaspartyl methyltransferase (Pimt) is a highly conserved enzyme utilising S-adenosylmethionine (AdoMet) to methylate aspartate residues of proteins damaged by age-related isomerisation and deamidation.	Aspartic Acid	129-138	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	41-45
10580153-1	1999	Protein L-isoaspartyl methyltransferase (Pimt) is a highly conserved enzyme utilising S-adenosylmethionine (AdoMet) to methylate aspartate residues of proteins damaged by age-related isomerisation and deamidation.	Aspartic Acid	129-138	methionine adenosyltransferase 1A	Rattus norvegicus	108-114
10559253-1	1999	Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase.	Aspartic Acid	53-63	pleckstrin	Homo sapiens	131-135
10842650-16	1999	In addition, ASP is a serious new candidate for an important role in insulin resistance.	Aspartic Acid	13-16	insulin	Homo sapiens	69-76
10559253-5	1999	Simultaneous replacement of the three serines in p47(phox) with aspartates or glutamates, each mimicking phosphorylated residues, is sufficient for disruption of the intramolecular interaction and resultant access to p22(phox).	Aspartic Acid	64-74	pleckstrin	Homo sapiens	49-52
10842650-17	1999	The ASP pathway plays a critical role in fatty acid metabolism and storage, and it has been suggested that ineffective storage of fatty acids by adipocytes due to a defect in the ASP pathway may lead to insulin resistance and Type 2 diabetes.	Aspartic Acid	4-7	insulin	Homo sapiens	203-210
10842650-17	1999	The ASP pathway plays a critical role in fatty acid metabolism and storage, and it has been suggested that ineffective storage of fatty acids by adipocytes due to a defect in the ASP pathway may lead to insulin resistance and Type 2 diabetes.	Aspartic Acid	179-182	insulin	Homo sapiens	203-210
10559253-5	1999	Simultaneous replacement of the three serines in p47(phox) with aspartates or glutamates, each mimicking phosphorylated residues, is sufficient for disruption of the intramolecular interaction and resultant access to p22(phox).	Aspartic Acid	64-74	pleckstrin	Homo sapiens	53-57
10559253-5	1999	Simultaneous replacement of the three serines in p47(phox) with aspartates or glutamates, each mimicking phosphorylated residues, is sufficient for disruption of the intramolecular interaction and resultant access to p22(phox).	Aspartic Acid	64-74	calcineurin like EF-hand protein 1	Homo sapiens	217-220
10559253-5	1999	Simultaneous replacement of the three serines in p47(phox) with aspartates or glutamates, each mimicking phosphorylated residues, is sufficient for disruption of the intramolecular interaction and resultant access to p22(phox).	Aspartic Acid	64-74	pleckstrin	Homo sapiens	221-225
10548550-6	1999	The PDK1-catalysed phosphorylation and activation of SGK2 and SGK3, like SGK1, is greatly potentiated by mutating Ser(356) and Ser(419) respectively to Asp, these residues being equivalent to the C-terminal phosphorylation site of PKB.	Aspartic Acid	152-155	3-phosphoinositide dependent protein kinase-1	Rattus norvegicus	4-8
10548561-7	1999	Sequence comparison with mammalian EHs suggested that Asp(192), Asp(348) and His(374) constituted the catalytic triad of the fungal EH.	Aspartic Acid	54-57	epoxide hydrolase 1, microsomal	Mus musculus	35-37
10535746-8	1999	Of these enzymes, only mitochondrial AspAT, a key enzyme of the malate-aspartate shuttle, was inhibited.	Aspartic Acid	71-80	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	37-42
10535747-4	1999	In contrast, an alphavbeta3 integrin-expressing cell line, SK-MEL-24, was able to adhere to OPN in an arginine-glycine-aspartic acid dependent manner.	Aspartic Acid	119-132	secreted phosphoprotein 1	Homo sapiens	92-95
10548561-7	1999	Sequence comparison with mammalian EHs suggested that Asp(192), Asp(348) and His(374) constituted the catalytic triad of the fungal EH.	Aspartic Acid	64-67	epoxide hydrolase 1, microsomal	Mus musculus	35-37
10548550-6	1999	The PDK1-catalysed phosphorylation and activation of SGK2 and SGK3, like SGK1, is greatly potentiated by mutating Ser(356) and Ser(419) respectively to Asp, these residues being equivalent to the C-terminal phosphorylation site of PKB.	Aspartic Acid	152-155	serum/glucocorticoid regulated kinase 2	Rattus norvegicus	53-57
10548550-6	1999	The PDK1-catalysed phosphorylation and activation of SGK2 and SGK3, like SGK1, is greatly potentiated by mutating Ser(356) and Ser(419) respectively to Asp, these residues being equivalent to the C-terminal phosphorylation site of PKB.	Aspartic Acid	152-155	serum/glucocorticoid regulated kinase family, member 3	Rattus norvegicus	62-66
10548550-6	1999	The PDK1-catalysed phosphorylation and activation of SGK2 and SGK3, like SGK1, is greatly potentiated by mutating Ser(356) and Ser(419) respectively to Asp, these residues being equivalent to the C-terminal phosphorylation site of PKB.	Aspartic Acid	152-155	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	73-77
10542291-8	1999	Furthermore, F1Aalpha is cleaved by a caspase-3-like protease at Asp(342), and the cleavage-resistant mutant is unable to induce apoptosis upon overexpression.	Aspartic Acid	65-68	fem-1 homolog B	Homo sapiens	13-21
10551865-6	1999	Mutation of the four Ser and Thr ERK consensus phosphorylation sites to Ala residues inhibited the ability of the receptor to redistribute to intracellular tubules in a p42(mapk/erk2)-dependent fashion; whereas mutation of the phosphorylation sites to Asp and Glu residues mimicked the effect of receptor phosphorylation.	Aspartic Acid	252-255	mitogen-activated protein kinase 1	Mus musculus	33-36
10551865-6	1999	Mutation of the four Ser and Thr ERK consensus phosphorylation sites to Ala residues inhibited the ability of the receptor to redistribute to intracellular tubules in a p42(mapk/erk2)-dependent fashion; whereas mutation of the phosphorylation sites to Asp and Glu residues mimicked the effect of receptor phosphorylation.	Aspartic Acid	252-255	cyclin-dependent kinase 20	Mus musculus	169-172
10543983-7	1999	Also alanine substitutions on the putative metal binding sites of the CD11c I-domain such as Asp(242) and Tyr(209) reduced its ability to bind fibrinogen.	Aspartic Acid	93-96	integrin subunit alpha X	Homo sapiens	70-75
10543983-7	1999	Also alanine substitutions on the putative metal binding sites of the CD11c I-domain such as Asp(242) and Tyr(209) reduced its ability to bind fibrinogen.	Aspartic Acid	93-96	fibrinogen beta chain	Homo sapiens	143-153
10556940-8	1999	Several peptides inhibited the [3H]-L-AP4 binding with the following rank order of potency: glutamate-glutamate&gt;glutamate-glutamate-leucine=aspartate - glutamate&gt;&gt;glutamate - glutamate-aspartate&gt;lactoyl-glutamate&gt;&gt;aspartate-aspartate.	Aspartic Acid	143-152	replication initiator 1	Rattus norvegicus	38-41
10597236-8	1999	The codon 90 Gly &gt; Asp alteration may represent a non-pathological polymorphism and consequently the mutation frequency reported in lung cancers may have been overstated and the designation of PPP2R1B as a tumor suppressor gene should be regarded with caution.	Aspartic Acid	22-25	protein phosphatase 2 scaffold subunit Abeta	Homo sapiens	196-203
10545198-1	1999	The contributions to catalysis of the conserved catalytic aspartate (Asp149) in the phosphorylase kinase catalytic subunit (PhK; residues 1-298) have been studied by kinetic and crystallographic methods.	Aspartic Acid	58-67	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	124-127
10556940-8	1999	Several peptides inhibited the [3H]-L-AP4 binding with the following rank order of potency: glutamate-glutamate&gt;glutamate-glutamate-leucine=aspartate - glutamate&gt;&gt;glutamate - glutamate-aspartate&gt;lactoyl-glutamate&gt;&gt;aspartate-aspartate.	Aspartic Acid	194-203	replication initiator 1	Rattus norvegicus	38-41
10576765-2	1999	There are two known polymorphisms in exon 11 of the DBP gene that result in amino acid variants: at codons 416 GAT--&gt;GAG (Asp--&gt;Glu) and 420 ACG--&gt;AAG (Thr--&gt;Lys).	Aspartic Acid	125-128	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
10578173-1	1999	Caspase stands for cysteine-dependent aspartate specific protease, and is a term coined to define proteases related to interleukin 1beta converting enzyme and CED-3.1 Thus their enzymatic properties are governed by a dominant specificity for substrates containing Asp, and by the use of a Cys side-chain for catalyzing peptide bond cleavage.	Aspartic Acid	264-267	intraflagellar transport 43	Homo sapiens	159-164
10537136-2	1999	A molecular mimic of phosphorylated PRL, which substitutes an aspartate residue for the normally phosphorylated serine (serine 179), has the same properties.	Aspartic Acid	62-71	prolactin	Homo sapiens	36-39
10537136-7	1999	JAK 2 activation was not seen in response to the aspartate mutant at either concentration.	Aspartic Acid	49-58	Janus kinase 2	Homo sapiens	0-5
10537136-8	1999	Signal transducer and activator of transcription 5 (STAT 5) activation was, however, just as robust for the aspartate-treated cells as for the other two groups.	Aspartic Acid	108-117	signal transducer and activator of transcription 5A	Homo sapiens	0-50
10537136-8	1999	Signal transducer and activator of transcription 5 (STAT 5) activation was, however, just as robust for the aspartate-treated cells as for the other two groups.	Aspartic Acid	108-117	signal transducer and activator of transcription 5A	Homo sapiens	52-58
10537136-9	1999	Time course experiments eliminated the possibility that STAT 5 phosphorylation in response to the aspartate mutant was the result of JAK 2 activation at earlier time points.	Aspartic Acid	98-107	signal transducer and activator of transcription 5A	Homo sapiens	56-62
10537136-9	1999	Time course experiments eliminated the possibility that STAT 5 phosphorylation in response to the aspartate mutant was the result of JAK 2 activation at earlier time points.	Aspartic Acid	98-107	Janus kinase 2	Homo sapiens	133-138
10537136-12	1999	A comparison between STAT 5a and STAT 5b activation showed a marked reduction in STAT 5b phosphorylation in response to the aspartate mutant, with concomitant reduction in STAT 5a-STAT 5b heterodimers.	Aspartic Acid	124-133	signal transducer and activator of transcription 5A	Homo sapiens	21-28
10449634-1	1999	The role of adhesion molecules like osteopontin and bone sialoprotein, both containing the Arg-Gly-Asp sequence have been shown to have a role in mineral formation, whereas fibronectin (FN), another adhesive protein, was never studied during the mineralization processes.	Aspartic Acid	99-102	secreted phosphoprotein 1	Homo sapiens	36-47
10537136-12	1999	A comparison between STAT 5a and STAT 5b activation showed a marked reduction in STAT 5b phosphorylation in response to the aspartate mutant, with concomitant reduction in STAT 5a-STAT 5b heterodimers.	Aspartic Acid	124-133	signal transducer and activator of transcription 5B	Homo sapiens	33-40
10537136-12	1999	A comparison between STAT 5a and STAT 5b activation showed a marked reduction in STAT 5b phosphorylation in response to the aspartate mutant, with concomitant reduction in STAT 5a-STAT 5b heterodimers.	Aspartic Acid	124-133	signal transducer and activator of transcription 5B	Homo sapiens	81-88
10537136-12	1999	A comparison between STAT 5a and STAT 5b activation showed a marked reduction in STAT 5b phosphorylation in response to the aspartate mutant, with concomitant reduction in STAT 5a-STAT 5b heterodimers.	Aspartic Acid	124-133	signal transducer and activator of transcription 5A	Homo sapiens	172-179
10537136-12	1999	A comparison between STAT 5a and STAT 5b activation showed a marked reduction in STAT 5b phosphorylation in response to the aspartate mutant, with concomitant reduction in STAT 5a-STAT 5b heterodimers.	Aspartic Acid	124-133	signal transducer and activator of transcription 5B	Homo sapiens	81-88
10537136-13	1999	STAT 5a activation, however, was indistinguishable between the wild-type and aspartate mutant.	Aspartic Acid	77-86	signal transducer and activator of transcription 5A	Homo sapiens	0-7
10537136-14	1999	We conclude that the nonproliferative aspartate mutant signals and activates STAT 5 without, or with minimal, use of JAK 2 or receptor phosphorylation.	Aspartic Acid	38-47	signal transducer and activator of transcription 5A	Homo sapiens	77-83
10605824-7	1999	In human and bovine DNase I four amino acid residues, Glu-13, Tyr-65, Val-67 and Ala-114 are involved in actin binding, whereas in the hen DNase I these positions were occupied by Asp, Phe, Ser and Phe, respectively.	Aspartic Acid	180-183	deoxyribonuclease 1	Bos taurus	20-27
10605824-7	1999	In human and bovine DNase I four amino acid residues, Glu-13, Tyr-65, Val-67 and Ala-114 are involved in actin binding, whereas in the hen DNase I these positions were occupied by Asp, Phe, Ser and Phe, respectively.	Aspartic Acid	180-183	deoxyribonuclease 1	Bos taurus	139-146
10520212-4	1999	One relatively common polymorphism in the methionine synthase gene (D919G) is an A to G transition at bp 2,756, which converts an aspartic acid residue believed to be part of a helix involved in co-factor binding to a glycine.	Aspartic Acid	130-143	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	42-61
10545445-6	1999	Interestingly, the prp2-1 allele contains a point mutation that changes glycine to aspartate, indicating that EMT1-201 does not act by classical missense suppression.	Aspartic Acid	83-92	Prp21p	Saccharomyces cerevisiae S288C	19-25
10545445-6	1999	Interestingly, the prp2-1 allele contains a point mutation that changes glycine to aspartate, indicating that EMT1-201 does not act by classical missense suppression.	Aspartic Acid	83-92	EMT1	Saccharomyces cerevisiae S288C	110-114
10608664-1	1999	Dihydrodipicolinate synthase (DHPS) is the main enzyme of a specific branch of the aspartate pathway leading to lysine biosynthesis in higher plants.	Aspartic Acid	83-92	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	30-34
10525080-14	1999	Furthermore, a conserved aspartate residue in the CB(1) receptor is required for normal communication with GIRK channels in oocytes demonstrating the interaction between receptor and channels is G protein dependent.	Aspartic Acid	25-34	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	107-111
10687175-1	1999	Modification of the structure of recombinant human IL-1 beta: deletion of the amino acids serine, asparagine, and asparagic acid in position 52-54 in mutant delta SND, led to major changes in its functional activity.	Aspartic Acid	114-128	interleukin 1 beta	Homo sapiens	51-60
10545132-3	1999	An aspartate (Asp) at position 226 in GIRK2 is crucial for Na+-dependent activation of GIRK1-GIRK2 heteromeric channels.	Aspartic Acid	3-12	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	87-92
10545132-3	1999	An aspartate (Asp) at position 226 in GIRK2 is crucial for Na+-dependent activation of GIRK1-GIRK2 heteromeric channels.	Aspartic Acid	14-17	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	87-92
10523634-7	1999	Substitution of alanine for an aspartic acid residue in the conserved XLD motif of Cbf5p (mutant cbf5D95A) abolishes in vivo pseudouridylation of rRNA.	Aspartic Acid	31-44	pseudouridine synthase CBF5	Saccharomyces cerevisiae S288C	83-88
10608665-6	1999	In vitro experiments demonstrated that the putative signaling factors can transfer the phosphoryl group from His-80 of ZmHP2 to Asp-90 of ZmRRs.	Aspartic Acid	128-131	histidine-containing phosphotransfer protein 2	Zea mays	119-124
10529239-7	1999	Reduced chains from MMP-3, MMP-7, and MT1-MMP digests of Fg and XL-Fb were subjected to direct sequence analyses and D/D-dimer alpha-chain showed cleavage at both alpha Asp 97-Phe 98 and alpha Asn 102-Asn 103.	Aspartic Acid	169-172	Fc gamma receptor and transporter	Homo sapiens	127-138
10512701-8	1999	Despite limited amino acid sequence homology among HPt domains, our analysis of YPD1 as a prototypical family member, indicates that these phosphotransfer domains are likely to share a similar fold and common features with regard to response regulator binding and mechanism for histidine-aspartate phosphoryl transfer.	Aspartic Acid	288-297	Ypd1p	Saccharomyces cerevisiae S288C	80-84
10510301-14	1999	The "hydrostatic versus osmotic pressure" approach probed the importance of water in aging, and also revealed that Asp-70 and Glu-197 are the major residues controlling both the dynamics and the structural organization of the water/hydrogen-bond network in the active-site gorge of BuChE.	Aspartic Acid	115-118	butyrylcholinesterase	Homo sapiens	282-287
10510301-15	1999	In wild-type BuChE both residues function like valves, whereas in the mutant enzymes the water network is slack, and residues Gly-70 and Asp-197 function like check valves, i.e. forced penetration of water into the gorge is not easily achieved, thereby facilitating the release of water.	Aspartic Acid	137-140	butyrylcholinesterase	Homo sapiens	13-18
10521267-4	1999	We have now cloned the zebrafish (Danio rerio) PS1 homologue (zf-PS1) to study its function in amyloidogenesis and to prove the critical requirement of an unusual aspartate residue within the seventh putative transmembrane domain.	Aspartic Acid	163-172	presenilin 1	Danio rerio	47-50
10521267-4	1999	We have now cloned the zebrafish (Danio rerio) PS1 homologue (zf-PS1) to study its function in amyloidogenesis and to prove the critical requirement of an unusual aspartate residue within the seventh putative transmembrane domain.	Aspartic Acid	163-172	presenilin 1	Danio rerio	62-68
10521267-10	1999	Mutagenizing this critical aspartate residue abolishes endoproteolysis of zf-PS1 and inhibits Abeta secretion in human cells.	Aspartic Acid	27-36	amyloid beta precursor protein	Homo sapiens	94-99
10506154-5	1999	Using site-directed mutagenesis, a conserved residue, Asp-289, in site a of PDE5 has been identified as being important for cyclic nucleotide discrimination in this site.	Aspartic Acid	54-57	phosphodiesterase 5A	Homo sapiens	76-80
10510301-0	1999	Hydration change during the aging of phosphorylated human butyrylcholinesterase: importance of residues aspartate-70 and glutamate-197 in the water network as probed by hydrostatic and osmotic pressures.	Aspartic Acid	104-113	butyrylcholinesterase	Homo sapiens	58-79
10527871-4	1999	UCH-6 belonged to members of the UCH family containing highly conserved Cys, His, and Asp domains and showed 86% amino acid identity to human UCH-L3.	Aspartic Acid	86-89	ubiquitin C-terminal hydrolase L3	Gallus gallus	0-5
10493937-0	1999	Asp-89: a critical residue in maintaining the oligomeric structure of sheep liver cytosolic serine hydroxymethyltransferase.	Aspartic Acid	0-3	serine hydroxymethyltransferase, cytosolic	Ovis aries	92-123
10493937-2	1999	In an attempt to unravel the role of a conserved aspartate (D89) in sheep-liver tetrameric serine hydroxymethyltransferase (SHMT), it was converted into aspargine by site-directed mutagenesis.	Aspartic Acid	49-58	serine hydroxymethyltransferase, cytosolic	Ovis aries	91-122
10493937-2	1999	In an attempt to unravel the role of a conserved aspartate (D89) in sheep-liver tetrameric serine hydroxymethyltransferase (SHMT), it was converted into aspargine by site-directed mutagenesis.	Aspartic Acid	49-58	serine hydroxymethyltransferase, cytosolic	Ovis aries	124-128
10525356-6	1999	However, the unusual amino acid substitutions found in insulin from P. annectens (e.g., GlyB21 --&gt; Ala, GluB22 --&gt; Asp, and ArgB23 --&gt; Asn) are not present in N. forsteri insulin, suggesting that they occurred in the Protopterus lineage after divergence of the genera.	Aspartic Acid	121-124	insulin	Homo sapiens	55-62
10491192-8	1999	In addition to phosphorylation of Ser472, phosphorylation of Thr305 also appears to contribute to the activation of Akt-3 because mutation of both these residues to aspartate increased the catalytic activity of Akt-3, whereas mutation to alanine inhibited activation.	Aspartic Acid	165-174	AKT serine/threonine kinase 3	Homo sapiens	116-121
10491192-8	1999	In addition to phosphorylation of Ser472, phosphorylation of Thr305 also appears to contribute to the activation of Akt-3 because mutation of both these residues to aspartate increased the catalytic activity of Akt-3, whereas mutation to alanine inhibited activation.	Aspartic Acid	165-174	AKT serine/threonine kinase 3	Homo sapiens	211-216
10521396-3	1999	The cleavage site was mapped to the aspartic acid at position 324 of RIP.	Aspartic Acid	36-49	receptor interacting serine/threonine kinase 1	Homo sapiens	69-72
10457361-5	1999	Furthermore, the transport of glycolytic hydrogen, produced by the glyceraldehyde 3-phosphate dehydrogenase-catalyzed reaction, from the cytosol into the mitochondria by means of the malate-aspartate shuttle was enhanced, this being due to alterations in the activities of malate dehydrogenase and glutamate oxaloacetate transaminase.	Aspartic Acid	190-199	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	67-107
10526943-2	1999	Hb analysis disclosed that the abnormal Hb was Hb Ube-2 [alpha68 (E17) Asn --&gt; Asp] and it accounted for 21.5% of the total Hb.	Aspartic Acid	82-85	ubiquitin like modifier activating enzyme 7	Homo sapiens	50-55
10504448-7	1999	In addition two novel mutations within the helix initiation motif of hHb6 were found in Scottish and Portuguese cases, in whom the same highly conserved asparagine residue N114 was mutated to histidine (N114H) or aspartic acid (N114D) residues, respectively.	Aspartic Acid	213-226	keratin 86	Homo sapiens	69-73
10497249-13	1999	In contrast, the mutation site of mutant H45A seems to be involved directly in the epimerization process, and the amino acids Asp-413 and Arg-420 of UDP-GlcNAc 2-epimerase/N-acetylmannosamine kinase are essential for the phosphorylation process.	Aspartic Acid	126-129	renin binding protein	Rattus norvegicus	153-171
10482572-7	1999	The effects of amino acid changes at position 287 on the level of infection via CCR5 showed that negatively charged residues (Glu and Asp) were optimal for efficient interaction whereas only bulky hydrophobic residues drastically reduced infection.	Aspartic Acid	134-137	C-C motif chemokine receptor 5	Homo sapiens	80-84
10672519-10	1999	Moreover, we show that residues Arg-37, Glu-52, Asp-56, Arg-73, and Arg-74 are involved in this interaction with the myosin rod.	Aspartic Acid	48-51	myosin heavy chain 14	Homo sapiens	117-123
10685364-6	1999	This HLA genotype expresses aspartic acid at position 57 and glycine at position 70 on the DQ beta chain, suggesting a capability to bind certain bacterial antigens.	Aspartic Acid	28-41	major histocompatibility complex, class II, DR beta 1	Homo sapiens	5-8
10517678-2	1999	In a general population of Caucasians a polymorphism at codon 905 of PP-1G from an aspartate to tyrosine has been reported to be associated with insulin resistance and hypersecretion.	Aspartic Acid	83-92	protein phosphatase 1 catalytic subunit gamma	Rattus norvegicus	69-74
10551417-4	1999	We formulate the hypothesis that suceptibility to IDDM is not only explained by the absence of Aspartate 57 (negative charge) from pocket 9 of DQB1 (P9DQ), but also by the presence of an electric charge (+/- vs. neutral), generated by residues 70, 71 and 74 in pockets 4 of DRB1 (P4DR) and DQB1 (P4DQ) molecules.	Aspartic Acid	95-104	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	143-147
10570924-4	1999	This observation suggests a novel role in proteolysis for residues of DPP IV distant from the Ser-Asp-His catalytic triad.	Aspartic Acid	98-101	dipeptidyl peptidase 4	Homo sapiens	70-76
10526139-3	1999	Rapid and transient glutamate and aspartate releases induced by BDNF were observed from cultured cortical, hippocampal, striatal and cerebellar neurons.	Aspartic Acid	34-43	brain derived neurotrophic factor	Homo sapiens	64-68
10526139-7	1999	Pretreatment with K252a and also TrkB-IgG completely blocked the glutamate and aspartate release elicited by BDNF, but not by NGF.	Aspartic Acid	79-88	neurotrophic receptor tyrosine kinase 2	Homo sapiens	33-37
10526139-7	1999	Pretreatment with K252a and also TrkB-IgG completely blocked the glutamate and aspartate release elicited by BDNF, but not by NGF.	Aspartic Acid	79-88	brain derived neurotrophic factor	Homo sapiens	109-113
10509015-1	1999	The HOM3 gene of Saccharomyces cerevisiae encodes aspartate kinase, which catalyses the first step in the branched pathway leading to the synthesis of threonine and methionine from aspartate.	Aspartic Acid	50-59	aspartate kinase	Saccharomyces cerevisiae S288C	4-8
10509015-3	1999	We have isolated and characterized three HOM3 mutants that show growth inhibition by threonine due to a severe, threonine-induced reduction of the carbon flow into the aspartate pathway, leading to methionine limitation.	Aspartic Acid	168-177	aspartate kinase	Saccharomyces cerevisiae S288C	41-45
10570924-2	1999	This paper reports the identification and possible significance of a novel conserved sequence motif Asp-Trp-(Val/Ile/Leu)-Tyr-Glu-Glu-Glu (DW(V/I/L)YEEE) in the predicted beta propeller domain of the DPP IV-like gene family.	Aspartic Acid	100-103	dipeptidyl peptidase 4	Homo sapiens	200-206
10464285-4	1999	Moreover, mutation of the three Asp residues of P69, which correspond to the three catalytic site Asp residues of pol beta, inactivated the enzyme without affecting its substrate and activator binding capacity, providing further credence to the concept that this region is the catalytic domain of P69.	Aspartic Acid	32-35	islet cell autoantigen 1	Homo sapiens	48-51
10473550-3	1999	We engineered in binding site 1 of hPRL a hGH-like zinc coordination site, by mutating Asp-183(hPRL) (homologous to Glu-174(hGH)) into Glu (D183E mutation).	Aspartic Acid	87-90	prolactin	Homo sapiens	35-39
10473550-3	1999	We engineered in binding site 1 of hPRL a hGH-like zinc coordination site, by mutating Asp-183(hPRL) (homologous to Glu-174(hGH)) into Glu (D183E mutation).	Aspartic Acid	87-90	prolactin	Homo sapiens	95-99
10556575-0	1999	Corrigendum to: "Exposure of the cryptic arg-gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase".	Aspartic Acid	49-52	thrombospondin 1	Homo sapiens	65-81
10464285-4	1999	Moreover, mutation of the three Asp residues of P69, which correspond to the three catalytic site Asp residues of pol beta, inactivated the enzyme without affecting its substrate and activator binding capacity, providing further credence to the concept that this region is the catalytic domain of P69.	Aspartic Acid	32-35	DNA polymerase beta	Homo sapiens	114-122
10464285-4	1999	Moreover, mutation of the three Asp residues of P69, which correspond to the three catalytic site Asp residues of pol beta, inactivated the enzyme without affecting its substrate and activator binding capacity, providing further credence to the concept that this region is the catalytic domain of P69.	Aspartic Acid	32-35	islet cell autoantigen 1	Homo sapiens	297-300
10483786-1	1999	The Trembler mouse (Tr) suffers from a dominantly inherited autosomal mutation (glycine to aspartic acid.	Aspartic Acid	91-104	peripheral myelin protein 22	Mus musculus	4-12
10464285-4	1999	Moreover, mutation of the three Asp residues of P69, which correspond to the three catalytic site Asp residues of pol beta, inactivated the enzyme without affecting its substrate and activator binding capacity, providing further credence to the concept that this region is the catalytic domain of P69.	Aspartic Acid	98-101	islet cell autoantigen 1	Homo sapiens	48-51
10464285-4	1999	Moreover, mutation of the three Asp residues of P69, which correspond to the three catalytic site Asp residues of pol beta, inactivated the enzyme without affecting its substrate and activator binding capacity, providing further credence to the concept that this region is the catalytic domain of P69.	Aspartic Acid	98-101	DNA polymerase beta	Homo sapiens	114-122
10498402-2	1999	In this study, we examined the relationship of a polymorphism (2756A--&gt;G, asp--&gt;gly) in the gene (MTR) for methionine synthase, another important enzyme in the same folate/methionine/homocyst(e)ine metabolic pathway, with risk of colorectal cancer among 356 cases and 476 cancer-free controls.	Aspartic Acid	77-80	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	113-132
10610126-4	1999	In this study, we characterized, in vitro, the putative cytokinin-responsive CKI1 His-kinase, in terms of His-Asp phosphorelays.	Aspartic Acid	110-113	casein kinase I	Arabidopsis thaliana	77-81
10610126-5	1999	It was demonstrated for the first time that the receiver domain in this sensor exhibits a strong phosphohistidine phosphatase activity toward some Arabidopsis HPt phosphotransmitters (AHP1 and AHP2), suggesting the functional importance of the receiver domain for a resumed interaction of the sensor His-kinase with other His-Asp phosphorelay components.	Aspartic Acid	326-329	histidine-containing phosphotransmitter 1	Arabidopsis thaliana	184-188
10610126-5	1999	It was demonstrated for the first time that the receiver domain in this sensor exhibits a strong phosphohistidine phosphatase activity toward some Arabidopsis HPt phosphotransmitters (AHP1 and AHP2), suggesting the functional importance of the receiver domain for a resumed interaction of the sensor His-kinase with other His-Asp phosphorelay components.	Aspartic Acid	326-329	histidine-containing phosphotransmitter 2	Arabidopsis thaliana	193-197
14538140-2	1999	Chymosin is bilobular, with Asp 32 and Asp 215 acting as the catalytic residues.	Aspartic Acid	28-31	chymosin	Bos taurus	0-8
10480597-5	1999	The glucose is predicted to form hydrogen bond interactions with the side chains of glucokinase residues Thr 168, Lys 169, Asn 204, Asp 205, Asn 231, and Glu 290, similar to those observed for brain hexokinase I.	Aspartic Acid	132-135	glucokinase	Homo sapiens	84-95
14538140-2	1999	Chymosin is bilobular, with Asp 32 and Asp 215 acting as the catalytic residues.	Aspartic Acid	39-42	chymosin	Bos taurus	0-8
10522802-1	1999	OBJECTIVE AND DESIGN: The role of a tetrapeptide derivative PEP 1261 {Boc-Lys(Boc)-Arg-Asp-Ser(tBu)-OtBu}, corresponding to residues 39-42 of human lactoferrin, has been tested in vitro in the modulation of neutrophil function.	Aspartic Acid	87-90	prolyl endopeptidase	Homo sapiens	60-63
10454555-1	1999	The activation of the cysteine proteases with aspartate specificity, termed caspases, is of fundamental importance for the execution of programmed cell death.	Aspartic Acid	46-55	caspase 6	Homo sapiens	76-84
10487707-4	1999	Eight of the 24 patients (33.3%) showed heterozygote polymorphism of codon 727 on the cytoplasmic tail of hTSHR with an amino acid substitution of aspartic acid to glutamic acid.	Aspartic Acid	147-160	thyroid stimulating hormone receptor	Homo sapiens	106-111
10698341-2	1999	Sequence analysis of ASP has shown that ASP is identical to C3adesArg the inactive fragment of the complement anaphylatoxin peptide, C3a.	Aspartic Acid	21-24	complement C3	Homo sapiens	60-63
11245096-5	1999	In the presence of aspirin (Asp 1 mmol.L-1)-treated EEC 1 x 10(9) cells.L-1, the aggregation of Asp (1 mmol.L-1) and methylene blue (10 mumol.L-1)-treated platelets in response to thrombin 500 U.L-1 and platelet activating factor (PAF 1 nmol.L-1) was markedly inhibited and was reversible, which was very similar to that in apyrase-treated platelets.	Aspartic Acid	28-31	PAF1 homolog, Paf1/RNA polymerase II complex component	Bos taurus	231-236
10493582-1	1999	The sequences of several members of the myosin family of molecular motors are evaluated using ASP (Ambivalent Structure Predictor), a new computational method.	Aspartic Acid	94-97	myosin, heavy chain 9, non-muscle	Gallus gallus	40-46
10493586-2	1999	In this study, we show that the originally isolated 15-residue guanylin, representing the COOH-terminal part of the prohormone, is released from the prohormone by cleavage of an Asp-Pro amide bond under conditions applied during the isolation procedures.	Aspartic Acid	178-181	guanylate cyclase activator 2A	Homo sapiens	63-71
11245096-5	1999	In the presence of aspirin (Asp 1 mmol.L-1)-treated EEC 1 x 10(9) cells.L-1, the aggregation of Asp (1 mmol.L-1) and methylene blue (10 mumol.L-1)-treated platelets in response to thrombin 500 U.L-1 and platelet activating factor (PAF 1 nmol.L-1) was markedly inhibited and was reversible, which was very similar to that in apyrase-treated platelets.	Aspartic Acid	96-99	PAF1 homolog, Paf1/RNA polymerase II complex component	Bos taurus	231-236
10438928-6	1999	Tat angiogenic effects correlate with the expression of the alpha v beta 3 integrin that is induced by bFGF and binds the arginine-glycine-aspartic acid (RGD) region of Tat.	Aspartic Acid	139-152	tyrosine aminotransferase	Homo sapiens	0-3
10432301-4	1999	By site-directed mutagenesis, the cleavage site was mapped to an Ala-Glu-Val-Asp(300) downward arrowGly(301) sequence located in the C-terminal portion of eIF-2alpha.	Aspartic Acid	77-80	eukaryotic translation initiation factor 2A	Homo sapiens	155-165
10466723-4	1999	We have identified a Drosophila homologue of synaptotagmin IV that is enriched on synaptic vesicles and contains an evolutionarily conserved substitution of aspartate to serine that abolishes its ability to bind membranes in response to Ca2+ influx.	Aspartic Acid	157-166	Synaptotagmin 1	Drosophila melanogaster	45-58
10438928-6	1999	Tat angiogenic effects correlate with the expression of the alpha v beta 3 integrin that is induced by bFGF and binds the arginine-glycine-aspartic acid (RGD) region of Tat.	Aspartic Acid	139-152	fibroblast growth factor 2	Homo sapiens	103-107
10438928-6	1999	Tat angiogenic effects correlate with the expression of the alpha v beta 3 integrin that is induced by bFGF and binds the arginine-glycine-aspartic acid (RGD) region of Tat.	Aspartic Acid	139-152	tyrosine aminotransferase	Homo sapiens	169-172
10438935-9	1999	Substitution of VCAM-1 aspartate at position 40, D40, within the conserved integrin binding site, diminishes binding to alpha D beta 2 and abrogates binding to the alpha D I domain.	Aspartic Acid	23-32	vascular cell adhesion molecule 1	Homo sapiens	16-22
10438935-9	1999	Substitution of VCAM-1 aspartate at position 40, D40, within the conserved integrin binding site, diminishes binding to alpha D beta 2 and abrogates binding to the alpha D I domain.	Aspartic Acid	23-32	tubulin beta 4B class IVb	Homo sapiens	128-134
10490145-0	1999	The Hb Tarrant [alpha126(H9)Asp--&gt;Asn]] mutation is localized in the alpha2-globin gene.	Aspartic Acid	28-31	hemoglobin subunit alpha 2	Homo sapiens	72-85
10438528-7	1999	Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser.	Aspartic Acid	155-158	zinc finger protein, FOG family member 2	Homo sapiens	51-57
10438528-7	1999	Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser.	Aspartic Acid	155-158	C-terminal binding protein 2	Mus musculus	122-128
10438490-0	1999	Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor.	Aspartic Acid	58-71	cholecystokinin	Homo sapiens	75-90
10438490-0	1999	Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor.	Aspartic Acid	58-71	cholecystokinin B receptor	Homo sapiens	158-184
10438490-7	1999	The screening of L-alanine-modified CCK peptides to bind and activate the wild type and mutant receptors allowed the identification of the interaction of the C-terminal Asp(8) of CCK with His(207).	Aspartic Acid	169-172	cholecystokinin	Homo sapiens	36-39
10438490-7	1999	The screening of L-alanine-modified CCK peptides to bind and activate the wild type and mutant receptors allowed the identification of the interaction of the C-terminal Asp(8) of CCK with His(207).	Aspartic Acid	169-172	cholecystokinin	Homo sapiens	179-182
10438490-10	1999	The affinity of CCK for the H207D-CCKBR mutant was 100-fold lower than for the H207A-CCKBR mutant, consistent with an electrostatic repulsion between the negative charges of the two interacting aspartic acids.	Aspartic Acid	194-208	cholecystokinin	Homo sapiens	16-19
10438490-10	1999	The affinity of CCK for the H207D-CCKBR mutant was 100-fold lower than for the H207A-CCKBR mutant, consistent with an electrostatic repulsion between the negative charges of the two interacting aspartic acids.	Aspartic Acid	194-208	cholecystokinin B receptor	Homo sapiens	34-39
10428809-13	1999	Finally, a thermodynamic analysis of PAM peptide binding to each of these mutants reveals that the positions Asp(56) and Tyr(72) in the K2(Pg)[C4G/E56D/L72Y] mutant are synergistically coupled in terms of their contribution to the enhancement of PAM peptide binding.	Aspartic Acid	109-112	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	37-40
10428809-13	1999	Finally, a thermodynamic analysis of PAM peptide binding to each of these mutants reveals that the positions Asp(56) and Tyr(72) in the K2(Pg)[C4G/E56D/L72Y] mutant are synergistically coupled in terms of their contribution to the enhancement of PAM peptide binding.	Aspartic Acid	109-112	RBPJ pseudogene 3	Homo sapiens	136-142
10428809-13	1999	Finally, a thermodynamic analysis of PAM peptide binding to each of these mutants reveals that the positions Asp(56) and Tyr(72) in the K2(Pg)[C4G/E56D/L72Y] mutant are synergistically coupled in terms of their contribution to the enhancement of PAM peptide binding.	Aspartic Acid	109-112	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	246-249
10463479-5	1999	All of the K-ras mutations were G-to-A transition mutations in the second position of codon 13 (glycine --&gt; aspartic acid).	Aspartic Acid	111-124	KRAS proto-oncogene, GTPase	Homo sapiens	11-16
10481267-2	1999	Eps15 has a tripartite structure comprising a NH2-terminal portion, which contains three EH domains, a central putative coiled-coil region, and a COOH-terminal domain containing multiple copies of the amino acid triplet Aspartate-Proline-Phenylalanine.	Aspartic Acid	220-229	epidermal growth factor receptor pathway substrate 15	Mus musculus	0-5
10400732-4	1999	Serp2 and CrmA both contain Asp at the P1 position within the serpin reactive site loop and yet are only 35% identical overall.	Aspartic Acid	28-31	stress associated endoplasmic reticulum protein family member 2	Homo sapiens	0-5
10400732-4	1999	Serp2 and CrmA both contain Asp at the P1 position within the serpin reactive site loop and yet are only 35% identical overall.	Aspartic Acid	28-31	CrmA or CPXV207 protein	Cowpox virus	10-14
10400673-0	1999	Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin.	Aspartic Acid	115-128	cholecystokinin A receptor	Homo sapiens	45-71
10409669-3	1999	The Bcl-2 protein, which inhibits apoptosis, is cleaved at Asp-34 by caspases during apoptosis and by recombinant caspase-3 in vitro.	Aspartic Acid	59-62	BCL2 apoptosis regulator	Homo sapiens	4-9
10409669-3	1999	The Bcl-2 protein, which inhibits apoptosis, is cleaved at Asp-34 by caspases during apoptosis and by recombinant caspase-3 in vitro.	Aspartic Acid	59-62	caspase 3	Homo sapiens	114-123
10423244-11	1999	It is likely that the behaviors of Tyr residues are controlled by the ligation of beta heme through His-beta 92(F8)--&gt;Val-beta 98(FG5)--&gt;Asp-beta 99(G1 )--&gt;Tyr-alpha 42(C7) or Tyr-beta 145(HC2).	Aspartic Acid	143-146	proline rich protein BstNI subfamily 3	Homo sapiens	147-157
10391914-8	1999	Mutated full-length p47(phox) with aspartic acid substitutions to mimic the effects of phosphorylations at serines 310 and 328 bind the p22(phox) proline-rich region in contrast to wild-type p47(phox).	Aspartic Acid	35-48	pleckstrin	Homo sapiens	20-23
10413511-0	1999	An aspartate residue at the extracellular boundary of TMII and an arginine residue in TMVII of the gastrin-releasing peptide receptor interact to facilitate heterotrimeric G protein coupling.	Aspartic Acid	3-12	gastrin releasing peptide receptor	Homo sapiens	99-133
10397733-4	1999	The arginine-glycine-aspartic acid (RGD) sequence present at the carboxyterminal of Tat mediates vascular cell migration and invasion by binding to the alpha5beta1 and alphavbeta3 integrins.	Aspartic Acid	21-34	tyrosine aminotransferase	Homo sapiens	84-87
10400690-7	1999	Inactive nNOS lacking CaM-binding ability was generated by mutation of Lys732-Lys-Leu to Asp732-Asp-Glu (Watanabe, Y., Hu, Y., and Hidaka, H. (1997) FEBS Lett.	Aspartic Acid	89-92	nitric oxide synthase 1	Rattus norvegicus	9-13
10400692-3	1999	Expression of a mutant Akt in which Lys179 in the kinase domain was replaced by aspartate also inhibited insulin-induced activation of glycogen synthase but had no effect on insulin activation of endogenous Akt.	Aspartic Acid	80-89	insulin	Cricetulus griseus	105-112
10393969-7	1999	To define the role of cyclin D3 in productive infection, the ICP0 binding site for cyclin D3 was mapped and mutagenized by substitution of aspartic acid codon 199 with the alanine codon.	Aspartic Acid	139-152	cyclin D3	Homo sapiens	83-92
10391914-8	1999	Mutated full-length p47(phox) with aspartic acid substitutions to mimic the effects of phosphorylations at serines 310 and 328 bind the p22(phox) proline-rich region in contrast to wild-type p47(phox).	Aspartic Acid	35-48	pleckstrin	Homo sapiens	24-28
10391914-8	1999	Mutated full-length p47(phox) with aspartic acid substitutions to mimic the effects of phosphorylations at serines 310 and 328 bind the p22(phox) proline-rich region in contrast to wild-type p47(phox).	Aspartic Acid	35-48	calcineurin like EF-hand protein 1	Homo sapiens	136-139
10377263-12	1999	The substitution of Arg197 of rat SP-A with Asp or Asn eliminated binding to annexin IV, whereas the substitution of Glu195 with Gln was silent.	Aspartic Acid	44-47	surfactant protein A1	Rattus norvegicus	34-38
10403802-2	1999	L-Asparaginase preparation derived from E. coli converts asparagine (Asn) and glutamine (Gln) to aspartate (Asp) and glutamate (Glu), respectively, and causes rapid depletion of Asn and Gln.	Aspartic Acid	97-106	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
10395903-7	1999	The conserved mammalian cell-attachment signal Arg-Gly-Asp is absent in the caiman DMP1.	Aspartic Acid	55-58	dentin matrix acidic phosphoprotein 1	Homo sapiens	83-87
10383384-5	1999	Plasmid rescue of both rluA- strains using an rluA gene carrying asparagine or threonine replacements for the highly conserved aspartate 64 demonstrated that neither mutant could form 23 S RNA pseudouridine 746 or tRNA pseudouridine 32 in vivo, showing that this conserved aspartate is essential for enzyme-catalyzed formation of both pseudouridines.	Aspartic Acid	127-136	23S rRNA pseudouridine(746) and tRNA pseudouridine(32) synthase	Escherichia coli str. K-12 substr. MG1655	23-27
10383384-5	1999	Plasmid rescue of both rluA- strains using an rluA gene carrying asparagine or threonine replacements for the highly conserved aspartate 64 demonstrated that neither mutant could form 23 S RNA pseudouridine 746 or tRNA pseudouridine 32 in vivo, showing that this conserved aspartate is essential for enzyme-catalyzed formation of both pseudouridines.	Aspartic Acid	127-136	23S rRNA pseudouridine(746) and tRNA pseudouridine(32) synthase	Escherichia coli str. K-12 substr. MG1655	46-50
10377239-0	1999	A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin.	Aspartic Acid	25-28	transferrin	Homo sapiens	43-54
10377263-12	1999	The substitution of Arg197 of rat SP-A with Asp or Asn eliminated binding to annexin IV, whereas the substitution of Glu195 with Gln was silent.	Aspartic Acid	44-47	annexin A4	Rattus norvegicus	77-87
10377239-0	1999	A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin.	Aspartic Acid	25-28	transferrin	Homo sapiens	91-102
10442769-4	1999	In order to stabilize the helical structures, we have recently synthesized and studied the PTHrP(1-34) analog [(Lys13-Asp17, Lys26-Asp30)]PTHrP(1-34)NH2, which contains lactam-constrained Lys-Asp side chains at positions i, i+4.	Aspartic Acid	118-121	parathyroid hormone like hormone	Homo sapiens	91-96
10377239-1	1999	The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind.	Aspartic Acid	61-64	transferrin	Homo sapiens	4-15
10377239-1	1999	The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind.	Aspartic Acid	61-64	transferrin	Homo sapiens	111-122
10465405-3	1999	This study confirmed the structure-based working hypothesis: The hydrophobic/hydrophilic character of amino acid residues 190 and 213 in the neighbourhood of Asp 189 in the S-1 pocket of thrombin (Ala/Val), trypsin (Ser/Val) and plasmin (Ser/Thr) define the specificity for the interaction with different P-1 residues of the inhibitors.	Aspartic Acid	158-161	coagulation factor II, thrombin	Homo sapiens	187-195
10442769-4	1999	In order to stabilize the helical structures, we have recently synthesized and studied the PTHrP(1-34) analog [(Lys13-Asp17, Lys26-Asp30)]PTHrP(1-34)NH2, which contains lactam-constrained Lys-Asp side chains at positions i, i+4.	Aspartic Acid	118-121	parathyroid hormone like hormone	Homo sapiens	138-143
10387075-1	1999	The role of the HELLGH (residues 450-455) motif in the sequence of rat dipeptidyl peptidase III (EC 3.4.14.4) was investigated by replacing Glu451 with an alanine or an aspartic acid residue and by replacing His450 and His455 with a tyrosine residue by site-directed mutagenesis.	Aspartic Acid	169-182	dipeptidylpeptidase 3	Rattus norvegicus	71-95
10420092-8	1999	The beta-endorphin region of lungfish POMC has the di-amino acid sequence tryptophan-aspartic acid in the N-terminal region and an additional glutamic acid residue in the C-terminal region of beta-endorphin - features found in fish beta-endorphin, but not tetrapod beta-endorphins.	Aspartic Acid	85-98	proopiomelanocortin S homeolog	Xenopus laevis	38-42
10364224-3	1999	To identify the direct target of PTPH1 in the cell, we generated a substrate-trapping mutant, in which an invariant aspartate residue was changed to alanine (D811A in PTPH1).	Aspartic Acid	116-125	protein tyrosine phosphatase non-receptor type 3	Homo sapiens	33-38
10364188-5	1999	246, 108-119) atomic model of the actin-tropomyosin complex, actin residue Asp-311 (Glu-311 in yeast) is predicted to have a high binding energy contribution to actin-tropomyosin binding.	Aspartic Acid	75-78	actin	Saccharomyces cerevisiae S288C	34-39
10364188-5	1999	246, 108-119) atomic model of the actin-tropomyosin complex, actin residue Asp-311 (Glu-311 in yeast) is predicted to have a high binding energy contribution to actin-tropomyosin binding.	Aspartic Acid	75-78	actin	Saccharomyces cerevisiae S288C	61-66
10387046-12	1999	This proton resonance is assigned to Hdelta2 of Asp 375, on the basis of comparison with crystal structures and the fact that this cross-peak was absent in the heteronuclear correlation spectrum of the inhibitor-D375G mutant enzyme complex.	Aspartic Acid	48-51	delta like canonical Notch ligand 4	Homo sapiens	37-44
10358006-1	1999	Conformational exchange has been demonstrated within the regulatory domain of calcium-saturated cardiac troponin C when bound to the NH2-terminal domain of cardiac troponin I-(1-80), and cardiac troponin I-(1-80)DD, having serine residues 23 and 24 mutated to aspartate to mimic the phosphorylated form of the protein.	Aspartic Acid	260-269	troponin C1, slow skeletal and cardiac type	Homo sapiens	96-114
10364188-5	1999	246, 108-119) atomic model of the actin-tropomyosin complex, actin residue Asp-311 (Glu-311 in yeast) is predicted to have a high binding energy contribution to actin-tropomyosin binding.	Aspartic Acid	75-78	actin	Saccharomyces cerevisiae S288C	61-66
10358043-0	1999	Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase.	Aspartic Acid	58-61	eosinophil peroxidase	Homo sapiens	86-107
10358043-12	1999	From a parallel study with LPO, we show that Asp-125 and Glu-275 are engaged in ester linkage.	Aspartic Acid	45-48	lactoperoxidase	Homo sapiens	27-30
10347200-4	1999	Asp-454, Ile-455, and Gly-457 of smooth muscle myosin were substituted by Ala, Met, and Ala, respectively, and the mechano-enzymatic activities were determined to study the role of these residues in myosin motor function.	Aspartic Acid	0-3	myosin heavy chain 14	Homo sapiens	47-53
10360950-10	1999	Remarkably, mutations of both Asp-373 and Glu-475 affected the Km for succinate in NaDC-1, suggesting dual roles for these residues in determining the affinity for substrate and cations.	Aspartic Acid	30-33	solute carrier family 13 member 2L homeolog	Xenopus laevis	83-89
10347143-4	1999	To determine whether the DNA polymerase activity of Rad30 was essential for its biological function, we made a mutation in the highly conserved SIDE sequence in Rad30, in which the aspartate and glutamate residues have each been changed to alanine.	Aspartic Acid	181-190	DNA-directed DNA polymerase eta	Saccharomyces cerevisiae S288C	52-57
10347143-4	1999	To determine whether the DNA polymerase activity of Rad30 was essential for its biological function, we made a mutation in the highly conserved SIDE sequence in Rad30, in which the aspartate and glutamate residues have each been changed to alanine.	Aspartic Acid	181-190	DNA-directed DNA polymerase eta	Saccharomyces cerevisiae S288C	161-166
10320738-2	1999	Potassium fluoride (KF), 440 mM trimethylamine chloride and exclusion of bovine serum albumin (BSA) decreased the activity of the enzyme, while ethylene glycol-bis (beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA) and the potassium salts of aspartate, gluconate, methylsulfate and monobasic phosphate increased its activity.	Aspartic Acid	249-258	albumin	Homo sapiens	80-93
10501559-3	1999	We also demonstrate by means of microdialysis that administration of Pr-IIGL abolished Abeta(1-42)-induced increases in extracellular aspartate and glutamate concentrations in the MBN, which coincide with a significant preservation of cholinergic MBN neurons and their cortical projections.	Aspartic Acid	134-143	amyloid beta precursor protein	Rattus norvegicus	87-92
10361244-4	1999	We observed a positive association between non-Asp residues at position 57 of the HLA-DQbeta chain and CVID, although much weaker than in IgAD.	Aspartic Acid	47-50	major histocompatibility complex, class II, DR beta 1	Homo sapiens	82-85
10408343-5	1999	Nevertheless after replacing the Asp with Sar in position 1 (Sar1) tachyphylaxis was again established.	Aspartic Acid	33-36	secretion associated Ras related GTPase 1A	Homo sapiens	61-65
10356309-11	1999	A 3-bp deletion was found on both IDUA alleles in each of the MPS I animals, predicting the deletion of a single aspartate residue from the feline IDUA polypeptide.	Aspartic Acid	113-122	alpha-L-iduronidase	Felis catus	34-38
10356309-11	1999	A 3-bp deletion was found on both IDUA alleles in each of the MPS I animals, predicting the deletion of a single aspartate residue from the feline IDUA polypeptide.	Aspartic Acid	113-122	alpha-L-iduronidase	Felis catus	147-151
10344216-1	1999	BACKGROUND: Caspases are a family of cysteine proteases capable of characteristically cleaving after an aspartic acid residue.	Aspartic Acid	104-117	caspase 1	Homo sapiens	12-20
10382669-1	1999	Mouse granzyme B is a member of the chymotrypsin family of serine proteinases that has an unusual preference for cleavage of substrates following aspartate residues.	Aspartic Acid	146-155	granzyme B	Mus musculus	6-16
10329657-2	1999	Using alanine scanning mutagenesis, the role in receptor activation of charged amino acids (Asp, Glu, Lys, and Arg) and cysteines in the extracellular loops (EL) of the human P2Y1 receptor has been investigated.	Aspartic Acid	92-95	purinergic receptor P2Y1	Homo sapiens	175-188
10350484-1	1999	The chemotaxis receptor for aspartate, Tar, generates responses by regulating the activity of an associated histidine kinase, CheA.	Aspartic Acid	28-37	RNA binding motif protein 8A	Homo sapiens	39-42
10344756-2	1999	Using gene targeting, we examined HCT116 cells that contain the Gly-13--&gt;Asp mutation of Ki-ras and activated Ki-ras-disrupted clones derived from HCT116.	Aspartic Acid	76-79	KRAS proto-oncogene, GTPase	Homo sapiens	92-98
10389946-3	1999	Modeling studies indicated that 4-(phenyl)-amino-6,7-dimethoxyquinazoline (parent compound WHI-258) would likely fit into the catalytic site of JAK3 and that derivatives of this compound that contain an OH group at the 4" position of the phenyl ring would more strongly bind to JAK3 because of added interactions with Asp-967, a key residue in the catalytic site of JAK3.	Aspartic Acid	318-321	Janus kinase 3	Homo sapiens	144-148
10382586-4	1999	RESULTS: The HLA genotypes DRB1*03/04(DQB1*57non-Asp) and DRB1*04/04(DQB1*57non-Asp) were present in 7.1% and 5.0% of offspring of parents with Type I diabetes.	Aspartic Acid	49-52	major histocompatibility complex, class II, DR beta 1	Homo sapiens	27-31
10382586-4	1999	RESULTS: The HLA genotypes DRB1*03/04(DQB1*57non-Asp) and DRB1*04/04(DQB1*57non-Asp) were present in 7.1% and 5.0% of offspring of parents with Type I diabetes.	Aspartic Acid	49-52	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	38-42
10382586-4	1999	RESULTS: The HLA genotypes DRB1*03/04(DQB1*57non-Asp) and DRB1*04/04(DQB1*57non-Asp) were present in 7.1% and 5.0% of offspring of parents with Type I diabetes.	Aspartic Acid	80-83	major histocompatibility complex, class II, DR beta 1	Homo sapiens	27-31
10382586-4	1999	RESULTS: The HLA genotypes DRB1*03/04(DQB1*57non-Asp) and DRB1*04/04(DQB1*57non-Asp) were present in 7.1% and 5.0% of offspring of parents with Type I diabetes.	Aspartic Acid	80-83	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	38-42
10382586-4	1999	RESULTS: The HLA genotypes DRB1*03/04(DQB1*57non-Asp) and DRB1*04/04(DQB1*57non-Asp) were present in 7.1% and 5.0% of offspring of parents with Type I diabetes.	Aspartic Acid	80-83	major histocompatibility complex, class II, DR beta 1	Homo sapiens	58-62
10382586-4	1999	RESULTS: The HLA genotypes DRB1*03/04(DQB1*57non-Asp) and DRB1*04/04(DQB1*57non-Asp) were present in 7.1% and 5.0% of offspring of parents with Type I diabetes.	Aspartic Acid	80-83	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	69-73
10382586-7	1999	By life-table analysis, the cumulative risk of developing islet autoantibodies by the age of 2 years was 20% (95% CI 9.4,30.6) for offspring carrying either the DRB1*03104(DQB1*57non-Asp) or the DRB1*04/04(DQB1*57non-Asp) genotype compared with 2.7% (95% CI 1.2,4.2) for offspring without these genotypes (p &lt; 0.0001).	Aspartic Acid	183-186	major histocompatibility complex, class II, DR beta 1	Homo sapiens	161-165
10382586-7	1999	By life-table analysis, the cumulative risk of developing islet autoantibodies by the age of 2 years was 20% (95% CI 9.4,30.6) for offspring carrying either the DRB1*03104(DQB1*57non-Asp) or the DRB1*04/04(DQB1*57non-Asp) genotype compared with 2.7% (95% CI 1.2,4.2) for offspring without these genotypes (p &lt; 0.0001).	Aspartic Acid	183-186	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	172-176
10382586-7	1999	By life-table analysis, the cumulative risk of developing islet autoantibodies by the age of 2 years was 20% (95% CI 9.4,30.6) for offspring carrying either the DRB1*03104(DQB1*57non-Asp) or the DRB1*04/04(DQB1*57non-Asp) genotype compared with 2.7% (95% CI 1.2,4.2) for offspring without these genotypes (p &lt; 0.0001).	Aspartic Acid	217-220	major histocompatibility complex, class II, DR beta 1	Homo sapiens	161-165
10382586-7	1999	By life-table analysis, the cumulative risk of developing islet autoantibodies by the age of 2 years was 20% (95% CI 9.4,30.6) for offspring carrying either the DRB1*03104(DQB1*57non-Asp) or the DRB1*04/04(DQB1*57non-Asp) genotype compared with 2.7% (95% CI 1.2,4.2) for offspring without these genotypes (p &lt; 0.0001).	Aspartic Acid	217-220	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	172-176
10475066-3	1999	The newly identified eNOS Glu-298--&gt;Asp mutation in exon 7 is common and likely to be functional.	Aspartic Acid	39-42	nitric oxide synthase 3	Homo sapiens	21-25
10475066-5	1999	We genotyped 763 white Australians undergoing coronary angiography for the eNOS Glu-298--&gt;Asp mutation.	Aspartic Acid	93-96	nitric oxide synthase 3	Homo sapiens	75-79
10475066-9	1999	In conclusion, the eNOS Glu-298--&gt;Asp mutation is common, occurring with an allele frequency of 32.5%, but is not associated with either the occurrence or severity of CAD in the Australian population or with other established coronary risk factors assessed in our study.	Aspartic Acid	37-40	nitric oxide synthase 3	Homo sapiens	19-23
10364405-0	1999	Phosphoenolpyruvate carboxykinase is involved in the decarboxylation of aspartate in the bundle sheath of maize We recently showed that maize (Zea mays L.) leaves contain appreciable amounts of phosphoenolpyruvate carboxykinase (PEPCK; R.P.	Aspartic Acid	72-81	phosphoenolpyruvate carboxykinase (ATP)	Zea mays	0-33
10364405-0	1999	Phosphoenolpyruvate carboxykinase is involved in the decarboxylation of aspartate in the bundle sheath of maize We recently showed that maize (Zea mays L.) leaves contain appreciable amounts of phosphoenolpyruvate carboxykinase (PEPCK; R.P.	Aspartic Acid	72-81	phosphoenolpyruvate carboxykinase (ATP)	Zea mays	1-34
10364405-0	1999	Phosphoenolpyruvate carboxykinase is involved in the decarboxylation of aspartate in the bundle sheath of maize We recently showed that maize (Zea mays L.) leaves contain appreciable amounts of phosphoenolpyruvate carboxykinase (PEPCK; R.P.	Aspartic Acid	72-81	phosphoenolpyruvate carboxykinase (ATP)	Zea mays	230-235
10400349-0	1999	The 3-methylaspartase reaction probed using 2H- and 15N-isotope effects for three substrates: a flip from a concerted to a carbocationic amino-enzyme elimination mechanism upon changing the C-3 stereochemistry in the substrate from R to S. The mechanisms of the elimination of ammonia from (2S,3S)-3-methylaspartic acid, (2S)-aspartic acid and (2S,3R)-3-methylaspartic acid, catalysed by the enzyme L-threo-3-methylaspartase ammonia-lyase (EC 4.3.1.2) have been probed using 15N-isotope effects.	Aspartic Acid	321-339	complement C3	Homo sapiens	190-193
10318835-3	1999	Comparison of primary sequence to that of lipoprotein and hepatic lipase reveals conservation of the serine, aspartic acid, and histidine catalytic residues as well as the 10 cysteine residues involved in disulfide bond formation.	Aspartic Acid	109-122	lipase C, hepatic type	Homo sapiens	58-72
10421440-4	1999	Group-specific labelling studies, performed on the purified native enzyme, indicated that one or more Trp, His and Asp/Glu are potentially important residues for PON activity.	Aspartic Acid	115-118	paraoxonase 1	Homo sapiens	162-165
10231522-9	1999	A structural analysis of the highly different affinity of SHV-1 and TEM-1 for the beta-lactamase inhibitory protein BLIP focuses on interactions involving Asp/Glu104.	Aspartic Acid	155-158	CD248 molecule	Homo sapiens	68-73
10400306-5	1999	We found out that administration of aspartate caused slowing of changes in concentration of all proteins observed (prealbumin, albumin, A1-globulin, haptoglobin and hemopexin) in non-irradiated and prealbumin, albumin, A1-globulin in irradiated rats in comparison with the values of proteins in rats drinking water only.	Aspartic Acid	36-45	haptoglobin	Rattus norvegicus	149-160
10400306-5	1999	We found out that administration of aspartate caused slowing of changes in concentration of all proteins observed (prealbumin, albumin, A1-globulin, haptoglobin and hemopexin) in non-irradiated and prealbumin, albumin, A1-globulin in irradiated rats in comparison with the values of proteins in rats drinking water only.	Aspartic Acid	36-45	hemopexin	Rattus norvegicus	165-174
10206993-4	1999	Single Asp or Ser substitutions, H18D, F21D, F21S, and double substitutions, H18A/F21D, H18A/F21S, and H18D/F21D, reduced up to 431-fold the binding affinity to CXCR1, CXCR2, and the Duffy antigen.	Aspartic Acid	7-10	C-X-C motif chemokine receptor 1	Homo sapiens	161-166
10322122-2	1999	The Asp 187--&gt;Asn (D187N) Asp 187--&gt;Tyr (D187Y) gelsolin mutations facilitate two proteolytic cuts in the parent protein generating a 71-residue fragment that forms amyloid fibrils in humans, putatively causing Finnish type familial amyloidosis (FAF).	Aspartic Acid	4-7	gelsolin	Homo sapiens	54-62
10322122-2	1999	The Asp 187--&gt;Asn (D187N) Asp 187--&gt;Tyr (D187Y) gelsolin mutations facilitate two proteolytic cuts in the parent protein generating a 71-residue fragment that forms amyloid fibrils in humans, putatively causing Finnish type familial amyloidosis (FAF).	Aspartic Acid	29-32	gelsolin	Homo sapiens	54-62
10210726-9	1999	Iontophoresis of monomeric human insulin analogue (B9 Asp, B27 Glu) through intact skin (untreated) produced a significant fall in PGL in diabetic rats.	Aspartic Acid	54-57	insulin	Bos taurus	33-40
10212266-0	1999	Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin.	Aspartic Acid	89-98	moesin	Homo sapiens	68-74
10212266-0	1999	Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin.	Aspartic Acid	89-98	moesin	Homo sapiens	128-134
10206957-3	1999	Instead, a serine, histidine, and two aspartic acids are important for signal peptidase activity by the Sec11p subunit of the yeast signal peptidase complex.	Aspartic Acid	38-52	signal peptidase complex catalytic subunit SEC11	Saccharomyces cerevisiae S288C	104-110
10331866-5	1999	Additionally, NMR studies further show that the Asp-X-Val-COOH peptide and a C-terminal peptide from a novel cytosolic protein named CAPON bind to the same pocket of the nNOS PDZ domain.	Aspartic Acid	48-51	nitric oxide synthase 1	Homo sapiens	170-174
10206968-7	1999	From our electrophysiological studies on channel mutants with respect to the pore histidine as well as the aspartate, we conclude that the common proton-supported shift in the voltage dependence of KST1 and KAT1 is based on distinct molecular elements.	Aspartic Acid	107-116	solute carrier family 5 member 11	Homo sapiens	198-202
10206968-7	1999	From our electrophysiological studies on channel mutants with respect to the pore histidine as well as the aspartate, we conclude that the common proton-supported shift in the voltage dependence of KST1 and KAT1 is based on distinct molecular elements.	Aspartic Acid	107-116	kynurenine aminotransferase 1	Homo sapiens	207-211
10206993-4	1999	Single Asp or Ser substitutions, H18D, F21D, F21S, and double substitutions, H18A/F21D, H18A/F21S, and H18D/F21D, reduced up to 431-fold the binding affinity to CXCR1, CXCR2, and the Duffy antigen.	Aspartic Acid	7-10	C-X-C motif chemokine receptor 2	Homo sapiens	168-173
10194517-2	1999	Occupation of these receptors, via Arg-Gly-Asp (RGD) recognition sequences, leads to activation of focal adhesion kinase (FAK).	Aspartic Acid	43-46	protein tyrosine kinase 2	Homo sapiens	99-120
10222201-1	1999	The high-resolution X-ray structures have been determined for ten complexes formed between bovine beta-trypsin and P1 variants (Gly, Asp, Glu, Gln, Thr, Met, Lys, His, Phe, Trp) of bovine pancreatic trypsin inhibitor (BPTI).	Aspartic Acid	133-136	serine protease 1	Bos taurus	98-110
10205157-4	1999	The P35 monomer possesses a solvent-exposed loop that projects from the protein"s main beta-sheet core and positions the requisite aspartate cleavage site at the loop"s apex.	Aspartic Acid	131-140	interleukin 12A	Homo sapiens	4-7
10206644-0	1999	Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.	Aspartic Acid	18-28	presenilin 1	Mus musculus	32-44
10206644-5	1999	Here we report that mutation of either of two conserved transmembrane (TM) aspartate residues in presenilin-1, Asp 257 (in TM6) and Asp 385 (in TM7), substantially reduces Abeta production and increases the amounts of the carboxy-terminal fragments of beta-amyloid precursor protein that are the substrates of gamma-secretase.	Aspartic Acid	75-84	presenilin 1	Mus musculus	97-109
10206644-5	1999	Here we report that mutation of either of two conserved transmembrane (TM) aspartate residues in presenilin-1, Asp 257 (in TM6) and Asp 385 (in TM7), substantially reduces Abeta production and increases the amounts of the carboxy-terminal fragments of beta-amyloid precursor protein that are the substrates of gamma-secretase.	Aspartic Acid	75-84	amyloid beta (A4) precursor protein	Mus musculus	172-177
10206644-5	1999	Here we report that mutation of either of two conserved transmembrane (TM) aspartate residues in presenilin-1, Asp 257 (in TM6) and Asp 385 (in TM7), substantially reduces Abeta production and increases the amounts of the carboxy-terminal fragments of beta-amyloid precursor protein that are the substrates of gamma-secretase.	Aspartic Acid	75-84	amyloid beta (A4) precursor protein	Mus musculus	252-282
10206644-5	1999	Here we report that mutation of either of two conserved transmembrane (TM) aspartate residues in presenilin-1, Asp 257 (in TM6) and Asp 385 (in TM7), substantially reduces Abeta production and increases the amounts of the carboxy-terminal fragments of beta-amyloid precursor protein that are the substrates of gamma-secretase.	Aspartic Acid	111-114	presenilin 1	Mus musculus	97-109
10206644-5	1999	Here we report that mutation of either of two conserved transmembrane (TM) aspartate residues in presenilin-1, Asp 257 (in TM6) and Asp 385 (in TM7), substantially reduces Abeta production and increases the amounts of the carboxy-terminal fragments of beta-amyloid precursor protein that are the substrates of gamma-secretase.	Aspartic Acid	111-114	amyloid beta (A4) precursor protein	Mus musculus	172-177
10206644-5	1999	Here we report that mutation of either of two conserved transmembrane (TM) aspartate residues in presenilin-1, Asp 257 (in TM6) and Asp 385 (in TM7), substantially reduces Abeta production and increases the amounts of the carboxy-terminal fragments of beta-amyloid precursor protein that are the substrates of gamma-secretase.	Aspartic Acid	132-135	amyloid beta (A4) precursor protein	Mus musculus	172-177
10206644-7	1999	Either of the Asp --> Ala mutations also prevented the normal endoproteolysis of presenilin-1 in the TM6 --> TM7 cytoplasmic loop.	Aspartic Acid	14-17	presenilin 1	Mus musculus	81-93
10206644-9	1999	Our results indicate that the two transmembrane aspartate residues are critical for both presenilin-1 endoproteolysis and gamma-secretase activity, and suggest that presenilin 1 is either a unique diaspartyl cofactor for gamma-secretase or is itself gamma-secretase, an autoactivated intramembranous aspartyl protease.	Aspartic Acid	48-57	presenilin 1	Mus musculus	89-101
10092660-6	1999	Replacement of five aspartate residues in the e2 loop with lysyl residues significantly compromised both the binding and functional capabilities of the C3a receptor mediated by intact C3a or by two C3a analog peptides.	Aspartic Acid	20-29	complement C3	Homo sapiens	152-155
10092660-6	1999	Replacement of five aspartate residues in the e2 loop with lysyl residues significantly compromised both the binding and functional capabilities of the C3a receptor mediated by intact C3a or by two C3a analog peptides.	Aspartic Acid	20-29	complement C3	Homo sapiens	184-187
10092660-6	1999	Replacement of five aspartate residues in the e2 loop with lysyl residues significantly compromised both the binding and functional capabilities of the C3a receptor mediated by intact C3a or by two C3a analog peptides.	Aspartic Acid	20-29	complement C3	Homo sapiens	184-187
10085232-3	1999	Residues at these positions were mutated in human GSTA1-1 (Met-208, Leu-108), rat GSTA3-3 (Glu-208, His-108) and rat GSTA5-5 (Asp-208, Tyr-108): in the active rat GSTA5-5 to those in the inactive GSTA1-1; and in the inactive human GSTA1-1 and rat GSTA3-3 to those in the active rat GSTA5-5.	Aspartic Acid	126-129	glutathione S-transferase alpha 3	Rattus norvegicus	117-124
10085232-3	1999	Residues at these positions were mutated in human GSTA1-1 (Met-208, Leu-108), rat GSTA3-3 (Glu-208, His-108) and rat GSTA5-5 (Asp-208, Tyr-108): in the active rat GSTA5-5 to those in the inactive GSTA1-1; and in the inactive human GSTA1-1 and rat GSTA3-3 to those in the active rat GSTA5-5.	Aspartic Acid	126-129	glutathione S-transferase alpha 5	Rattus norvegicus	117-122
10085232-4	1999	These studies show clearly that, in all three GSTs, an aspartate residue at position 208 is a prerequisite for high activity in aflatoxin-exo-8,9-epoxide conjugation, although this alone is not sufficient; other residues in the vicinity, particularly residues 103-112, are important, perhaps for the optimal orientation of the aflatoxin-exo-8,9-epoxide in the active site for catalysis to occur.	Aspartic Acid	55-64	glutathione S-transferase alpha 1	Homo sapiens	46-50
10089309-6	1999	The Glu192 residue of thrombin adopts an extended conformation, which allows the L-cyclohexylglycyl residue in the P2 retro-binding position of the inhibitors to occupy a similar site to the P3 aspartate in thrombin platelet-receptor peptides bound to thrombin.	Aspartic Acid	194-203	coagulation factor II, thrombin	Homo sapiens	22-30
10089309-6	1999	The Glu192 residue of thrombin adopts an extended conformation, which allows the L-cyclohexylglycyl residue in the P2 retro-binding position of the inhibitors to occupy a similar site to the P3 aspartate in thrombin platelet-receptor peptides bound to thrombin.	Aspartic Acid	194-203	coagulation factor II, thrombin	Homo sapiens	207-215
10089309-6	1999	The Glu192 residue of thrombin adopts an extended conformation, which allows the L-cyclohexylglycyl residue in the P2 retro-binding position of the inhibitors to occupy a similar site to the P3 aspartate in thrombin platelet-receptor peptides bound to thrombin.	Aspartic Acid	194-203	coagulation factor II, thrombin	Homo sapiens	207-215
10092660-5	1999	The e2 loop sequences adjacent to the transmembrane domains contain multiple aspartate residues and are found to play an important role in C3a binding based on deletion mutagenesis.	Aspartic Acid	77-86	complement C3	Homo sapiens	139-142
10198296-5	1999	In addition, the concentrations of the essential amino acids and aspartate in the liver decreased in response to GH treatment.	Aspartic Acid	65-74	growth hormone 1	Homo sapiens	113-115
10194517-2	1999	Occupation of these receptors, via Arg-Gly-Asp (RGD) recognition sequences, leads to activation of focal adhesion kinase (FAK).	Aspartic Acid	43-46	protein tyrosine kinase 2	Homo sapiens	122-125
10074180-3	1999	Aspartic acid 33 in the extracellular juxtamembrane region of the E5 protein is important for cell transformation and interaction with the PDGF beta receptor.	Aspartic Acid	0-13	platelet derived growth factor, B polypeptide	Mus musculus	139-148
10074140-10	1999	Pit1 and HaPit1 have aspartate at 550, whereas ChoPit1 has threonine at this position.	Aspartic Acid	21-30	POU class 1 homeobox 1	Homo sapiens	0-4
10074140-11	1999	We assessed the significance of this difference for GALV infection by replacing the aspartate 550 in Pit1 with threonine.	Aspartic Acid	84-93	POU class 1 homeobox 1	Homo sapiens	101-105
10082566-5	1999	Stable expression of a Rad51 mutant in which the aspartic acid residues were mutated to alanines (AVLA/N) confirmed that the DVLD/N site is responsible for the cleavage of Rad51 in IR-induced apoptosis.	Aspartic Acid	49-62	RAD51 recombinase	Homo sapiens	23-28
10419027-8	1999	The mutated SHBG is characterized by a point mutation (Asp 327 --&gt; Asn) causing an additional N-glycosylation site, which does not affect the binding of steroids to SHBG.	Aspartic Acid	55-58	sex hormone binding globulin	Homo sapiens	12-16
10082512-7	1999	Substitution of the C-terminal Ser-Thr phosphorylation sites with the phosphomimetic Asp in the region ISNSHPLSLTSDQ between amino acids 395 and 407 [IRF-3(5D)], but not the adjacent S385 and S386 residues, generates a constitutively activated DNA binding form of IRF-3.	Aspartic Acid	85-88	interferon regulatory factor 3	Homo sapiens	150-155
10082512-7	1999	Substitution of the C-terminal Ser-Thr phosphorylation sites with the phosphomimetic Asp in the region ISNSHPLSLTSDQ between amino acids 395 and 407 [IRF-3(5D)], but not the adjacent S385 and S386 residues, generates a constitutively activated DNA binding form of IRF-3.	Aspartic Acid	85-88	interferon regulatory factor 3	Homo sapiens	264-269
10082512-8	1999	In contrast, substitution of S385 and S386 with either Ala or Asp inhibits both DNA binding and transactivation activities of the IRF-3(5D) protein.	Aspartic Acid	62-65	interferon regulatory factor 3	Homo sapiens	130-135
10201402-5	1999	The enzyme contains a lipase-like catalytic triad, Ser 202, Asp 308 and His 338, consistent with mutational studies that implicate the homologous Ser 424, Asp 693 and His 723 in the catalytic triad in human HSL.	Aspartic Acid	60-63	lipase E, hormone sensitive type	Homo sapiens	207-210
10085101-4	1999	Within this region, GIRK2 has an aspartate at position 226, whereas GIRK1 has an asparagine at the equivalent position (217).	Aspartic Acid	33-42	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	20-25
10085070-6	1999	Replacement of an autophosphorylated serine (Ser79) of cGKIbeta with an aspartic acid resulted in a mutant kinase with constitutive kinase activity in vitro and in vivo.	Aspartic Acid	72-85	protein kinase cGMP-dependent 1	Homo sapiens	55-63
10080941-5	1999	We show that this high-affinity interaction involves multiple contact points including Tcf4 Asp-16, which is essential for beta-catenin binding.	Aspartic Acid	92-95	transcription factor 4	Homo sapiens	87-91
10085101-10	1999	We conclude that aspartate 226 in GIRK2 plays a crucial role in Na+-dependent gating of GIRK1/GIRK2 channels.	Aspartic Acid	17-26	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	34-39
10080941-5	1999	We show that this high-affinity interaction involves multiple contact points including Tcf4 Asp-16, which is essential for beta-catenin binding.	Aspartic Acid	92-95	catenin beta 1	Homo sapiens	123-135
10085101-10	1999	We conclude that aspartate 226 in GIRK2 plays a crucial role in Na+-dependent gating of GIRK1/GIRK2 channels.	Aspartic Acid	17-26	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	88-93
10085113-0	1999	Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.	Aspartic Acid	39-52	atrophin 1	Homo sapiens	12-22
10085101-10	1999	We conclude that aspartate 226 in GIRK2 plays a crucial role in Na+-dependent gating of GIRK1/GIRK2 channels.	Aspartic Acid	17-26	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	94-99
10095028-1	1999	We investigated immunohistochemically the localization of amyloid beta-protein (Abeta) with amino-terminal aspartate (N1[D]) in brains of patients with Alzheimer"s disease, diffuse Lewy body disease and Down"s syndrome.	Aspartic Acid	107-116	amyloid beta precursor protein	Homo sapiens	80-85
10090732-5	1999	When the T state interface is weakened by Asp --&gt; Asn substitution at a quaternary H-bond (HbK), the Fe-His bond is relaxed and becomes responsive to allosteric effectors.	Aspartic Acid	42-45	hemoglobin subunit mu	Homo sapiens	94-97
10082949-10	1999	Since Glu-85 and/or Asp-86 of TnC have also been demonstrated to be involved in Ca2+-dependent regulation through interaction with TnT, this region of TnC must be critical for troponin function.	Aspartic Acid	20-23	tenascin C	Homo sapiens	30-33
10214948-6	1999	In vitro assay with synthetic peptides demonstrated that a VPE exhibited activity towards Asp residues and that a VPE cleaved an Asp-Gln bond to remove the N-terminal propeptide.	Aspartic Acid	90-93	vacuolar-processing enzyme	Ricinus communis	59-62
10214948-6	1999	In vitro assay with synthetic peptides demonstrated that a VPE exhibited activity towards Asp residues and that a VPE cleaved an Asp-Gln bond to remove the N-terminal propeptide.	Aspartic Acid	129-132	vacuolar-processing enzyme	Ricinus communis	59-62
10214948-6	1999	In vitro assay with synthetic peptides demonstrated that a VPE exhibited activity towards Asp residues and that a VPE cleaved an Asp-Gln bond to remove the N-terminal propeptide.	Aspartic Acid	129-132	vacuolar-processing enzyme	Ricinus communis	114-117
10075657-9	1999	The Ile-33 --&gt; Gln point mutant completely inhibited and Arg-38 --&gt; Gln and Ser-36 --&gt; Asp point mutants reduced neurogranin/CaM interactions.	Aspartic Acid	96-99	neurogranin	Homo sapiens	122-133
10075657-9	1999	The Ile-33 --&gt; Gln point mutant completely inhibited and Arg-38 --&gt; Gln and Ser-36 --&gt; Asp point mutants reduced neurogranin/CaM interactions.	Aspartic Acid	96-99	calmodulin 1	Homo sapiens	134-137
10075660-6	1999	These results suggest that Asp-314 and Thr-315 both play critical structural roles in stabilizing the heme domain and subunit interactions in mouse nNOS.	Aspartic Acid	27-30	nitric oxide synthase 1, neuronal	Mus musculus	148-152
10087941-9	1999	Homozygous deletion in p16INK4A/p15INK4B genes and a codon 259 missense point mutation (GAC--&gt;TAC; Asp--&gt;Tyr) in the TP53 gene were observed in one human papilloma positive scrotal carcinoma case.	Aspartic Acid	102-105	tumor protein p53	Homo sapiens	123-127
10052953-7	1999	PON1 chemical modification with the Trp-selective reagent, N-bromosuccinimide, and the Asp/Glu-selective, dicyclohexylcarbodiimide, established that Trp and Asp/Glu residues are components of the PON1 active center and calcium-binding sites.	Aspartic Acid	157-160	paraoxonase 1	Homo sapiens	0-4
10052953-7	1999	PON1 chemical modification with the Trp-selective reagent, N-bromosuccinimide, and the Asp/Glu-selective, dicyclohexylcarbodiimide, established that Trp and Asp/Glu residues are components of the PON1 active center and calcium-binding sites.	Aspartic Acid	157-160	paraoxonase 1	Homo sapiens	196-200
10052953-10	1999	Twelve amino acids among conserved His and Asp/Glu residues were found essential for PON1 arylesterase and organophosphatase activities: H114, H133, H154, H242, H284, D53, D168, D182, D268, D278, E52, and E194.	Aspartic Acid	43-46	paraoxonase 1	Homo sapiens	85-89
10064698-5	1999	When the carboxyl-terminal half of the hydrophobic transmembrane polypeptide in the FR-alpha/LDLR chimera was altered by introduction of negatively charged (Asp) residues, or when the cytosolic domain in the chimera was deleted, the mutated proteins became GPI-anchored.	Aspartic Acid	157-160	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	84-92
10049337-0	1999	His ... Asp catalytic dyad of ribonuclease A: histidine pKa values in the wild-type, D121N, and D121A enzymes.	Aspartic Acid	8-11	ribonuclease pancreatic	Bos taurus	30-44
10049337-1	1999	Bovine pancreatic ribonuclease A (RNase A) has a conserved His ... Asp catalytic dyad in its active site.	Aspartic Acid	67-70	ribonuclease pancreatic	Bos taurus	18-32
10049337-1	1999	Bovine pancreatic ribonuclease A (RNase A) has a conserved His ... Asp catalytic dyad in its active site.	Aspartic Acid	67-70	ribonuclease pancreatic	Bos taurus	34-41
10049337-10	1999	Together, the data indicate that the aspartate residue in the His ... Asp catalytic dyad of RNase A has a measurable but modest effect on the ionization of the adjacent histidine residue.	Aspartic Acid	37-46	ribonuclease pancreatic	Bos taurus	92-99
10049337-10	1999	Together, the data indicate that the aspartate residue in the His ... Asp catalytic dyad of RNase A has a measurable but modest effect on the ionization of the adjacent histidine residue.	Aspartic Acid	70-73	ribonuclease pancreatic	Bos taurus	92-99
10213871-2	1999	Since the pivotal demonstration in 1984 by Pierschbacher and Ruoslahti that cell adhesion mediated by fibronectin could be inhibited by the simple tripeptide, Arg-Gly-Asp (RGD), then number of other peptide sequences have been shown to recapitulate integrin-ligand interactions.	Aspartic Acid	167-170	fibronectin 1	Homo sapiens	102-113
10102990-5	1999	The essential three amino acids in the active site triad, His, Asp, and Ser, and the single putative N-glycosylation site were conserved in human and mouse neuropsin.	Aspartic Acid	63-66	opsin 5	Mus musculus	156-165
10051312-5	1999	Comparison of mouse PR3 genomic structure with that of its human counterpart indicates that: 1) the mPR3 gene spans 7 kb organized in 5 exons and 4 introns, 2) the codons of His-Asp-Ser of the catalytic site are conserved and spread out over different exons, similar to the human gene, and 3) the gene product encodes a pre-proform of the protein.	Aspartic Acid	178-181	proteinase 3	Mus musculus	20-23
10069885-3	1999	OBJECTIVE: The purpose of this study was to evaluate the measurement by enzyme immunoassay of extracellular polysaccharides of Aspergillus and Penicillium species (EPS-Asp/Pen ) in house dust as a marker for fungal exposure and to study the relations between EPS-Asp/Pen levels and home dampness and respiratory symptoms in children.	Aspartic Acid	127-130	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	172-175
10084595-0	1999	Human leukocyte antigen-DQB1* genotypes encoding aspartate at position 57 are associated with 3beta-hydroxysteroid dehydrogenase autoimmunity in premature ovarian failure.	Aspartic Acid	49-58	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	24-28
10084595-5	1999	As the DQB1*0301 and -0603 genes share an identical codon at position 57 (aspartate, Asp), we analyzed the frequency of DQbeta-Asp57 encoding DQB1 genes in our series.	Aspartic Acid	74-83	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	7-11
10084595-5	1999	As the DQB1*0301 and -0603 genes share an identical codon at position 57 (aspartate, Asp), we analyzed the frequency of DQbeta-Asp57 encoding DQB1 genes in our series.	Aspartic Acid	85-88	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	7-11
10084317-0	1999	A novel glutamic acid to aspartic acid mutation near the end of the 2B rod domain in the keratin 1 chain in epidermolytic hyperkeratosis.	Aspartic Acid	25-38	keratin 1	Homo sapiens	89-98
10084317-1	1999	We report a mutation in a mild case of epidermolytic hyperkeratosis that results in a glutamic acid to aspartic acid substitution in a novel location, codon 477 or position 106 of the 2B rod domain of the keratin 1 chain.	Aspartic Acid	103-116	keratin 1	Homo sapiens	205-214
10051312-5	1999	Comparison of mouse PR3 genomic structure with that of its human counterpart indicates that: 1) the mPR3 gene spans 7 kb organized in 5 exons and 4 introns, 2) the codons of His-Asp-Ser of the catalytic site are conserved and spread out over different exons, similar to the human gene, and 3) the gene product encodes a pre-proform of the protein.	Aspartic Acid	178-181	proteinase 3	Mus musculus	100-104
10026181-6	1999	Isolated XPG proteins with Asp-77 or Glu-791 substitutions did not cleave DNA.	Aspartic Acid	27-30	ERCC excision repair 5, endonuclease	Homo sapiens	9-12
10069801-3	1999	In P2 peptide, there are two tripeptide sequences, Asp-Glu-Glu and Tyr-Gln-Gln, that are also present in the EGF receptor.	Aspartic Acid	51-54	epidermal growth factor receptor	Homo sapiens	109-121
10069801-5	1999	Of the five phosphate acceptor sites in the EGF receptor, clustered in the extreme C-terminal tail, phosphorylation of three tyrosine residues (992, 1068, and 1086) located between Asp-Glu-Glu and Gln-Gln is necessary for Ab P2 binding.	Aspartic Acid	181-184	epidermal growth factor receptor	Homo sapiens	44-56
10191072-1	1999	The arrangement of mitochondrial tRNA genes for lysine (K) and aspartate (D) from the junction of the cytochrome oxidase II and ATPase 8 genes was determined in a range of hymenopteran taxa.	Aspartic Acid	63-72	transfer RNA:Lysine-TTT 2-2	Drosophila melanogaster	33-37
11225055-1	1999	Compartmentalization of human cytosolic malate dehydrogenase, hcMDH, together with its isozyme partner-mitochondrial form, hmMDH, plays an important role in the aerobic metabolism of the malate-aspartate shuttle and the citric acid cycle.	Aspartic Acid	194-203	malate dehydrogenase 1	Homo sapiens	30-60
10024455-5	1999	The active site of PTPS consists of the pterin-anchoring Glu A107 neighboured by two catalytic motifs: a Zn(II) binding site and an intersubunit catalytic triad formed by Cys A42, Asp B88 and His B89.	Aspartic Acid	180-183	6-pyruvoyltetrahydropterin synthase	Homo sapiens	19-23
10199125-2	1999	When both shuttles were halted in mGPDH-deficient islets treated with aminooxyacetate, an inhibitor of the malate-aspartate shuttle, glucose-induced insulin secretion was almost completely abrogated.	Aspartic Acid	114-123	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	34-39
10199158-1	1999	Two rapid-acting insulin analogues, Lys(B28), Pro(B29)-human insulin (insulin lispro) and Asp(B28)-human insulin (insulin aspart) are developed and introduced into the clinical trials or applications recently.	Aspartic Acid	90-93	insulin	Homo sapiens	17-24
10026154-9	1999	These data suggest that Arg-347 plays an important structural role in CFTR, at least in part by forming a salt bridge with Asp-924; cystic fibrosis-associated mutations disrupt this interaction.	Aspartic Acid	123-126	CF transmembrane conductance regulator	Homo sapiens	70-74
10049754-0	1999	Mechanism of Ret activation by a mutation at aspartic acid 631 identified in sporadic pheochromocytoma.	Aspartic Acid	45-58	ret proto-oncogene	Homo sapiens	13-16
10026228-8	1999	Unexpectedly, mutation of an Asp-Lys-Asp motif within domain A identified a putative cytoplasmic membrane-associated export signal that mediates Cdx-3 compartmentalization.	Aspartic Acid	29-32	caudal type homeobox 4	Mus musculus	145-150
10026228-8	1999	Unexpectedly, mutation of an Asp-Lys-Asp motif within domain A identified a putative cytoplasmic membrane-associated export signal that mediates Cdx-3 compartmentalization.	Aspartic Acid	37-40	caudal type homeobox 4	Mus musculus	145-150
10049754-1	1999	Mutations at aspartic acid 631 in Ret were reported in sporadic pheochromocytoma and medullary thyroid carcinoma.	Aspartic Acid	13-26	ret proto-oncogene	Homo sapiens	34-37
10049754-3	1999	Among them, RET cDNA with a mutation of aspartic acid to tyrosine (D631Y) that was reported in sporadic pheochromocytoma showed high transforming activity.	Aspartic Acid	40-53	ret proto-oncogene	Homo sapiens	12-15
9990072-5	1999	All patients with adult sporadic mastocytosis had somatic c-KIT mutations in codon 816 causing substitution of valine for aspartate and spontaneous activation of mast cell growth factor receptor (P = 0.0001).	Aspartic Acid	122-131	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	58-63
9990034-6	1999	We mapped the in vivo phosphorylation sites of PS-2 to serine residues 327 and 330, which are localized immediately adjacent to the cleavage sites of caspases after aspartate residues 326 and 329.	Aspartic Acid	165-174	presenilin 2	Homo sapiens	47-51
10022832-3	1999	The inhibitory state of PDE4D3, engendered by ERK2 phosphorylation, was mimicked by the Ser579--&gt;Asp mutant form of PDE4D3.	Aspartic Acid	100-103	mitogen-activated protein kinase 1	Mus musculus	46-50
9933611-5	1999	GF14 binding to NR fragments was dependent on Ser-534, since Asp or Ala substitutions at this site blocked the interaction.	Aspartic Acid	61-64	nitrate reductase 1	Arabidopsis thaliana	16-18
10064272-0	1999	Insertion of the Asp-Ser/Phe sequence in the P" position of hirutonin provides molecules having both antithrombin and disintegrin activity.	Aspartic Acid	17-20	serpin family C member 1	Homo sapiens	101-113
10064272-2	1999	These peptides were derived from hirutonins, a class of potent proteolytically resistant thrombin inhibitors, in which a dipeptidyl sequence, Asp-Phe or Asp-Ser, was introduced after the proteolytically resistant ketomethylene arginyl glycine isostere.	Aspartic Acid	142-145	coagulation factor II, thrombin	Homo sapiens	89-97
9950658-2	1999	Small-molecule antagonists of GP IIb/IIIa based on the Arg-Gly-Asp (RGD) sequence show similar benefit, and some of these agents are orally active.	Aspartic Acid	63-66	integrin subunit alpha 2b	Homo sapiens	30-36
9933611-6	1999	Revertants with second site substitutions restoring interaction between GF14omega and the Ala- or Asp-substituted NR fragments were identified.	Aspartic Acid	98-101	general regulatory factor 2	Arabidopsis thaliana	72-81
9933611-6	1999	Revertants with second site substitutions restoring interaction between GF14omega and the Ala- or Asp-substituted NR fragments were identified.	Aspartic Acid	98-101	nitrate reductase 1	Arabidopsis thaliana	114-116
9971736-2	1999	The protein designated FEZ1 (fasciculation and elongation protein zeta-1) consisting of 393 amino acid residues shows a high Asp/Glu content and contains several regions predicted to form amphipathic helices.	Aspartic Acid	125-128	fasciculation and elongation protein zeta 1	Rattus norvegicus	23-27
9918902-1	1999	An ELISA was developed for the measurement of N-telopeptides of the alpha2(I) collagen chain containing an isomerized Asp-Gly bond (beta-peptide) using polyclonal antibodies raised against the synthetic peptide.	Aspartic Acid	118-121	collagen type I alpha 2 chain	Homo sapiens	68-86
9971736-2	1999	The protein designated FEZ1 (fasciculation and elongation protein zeta-1) consisting of 393 amino acid residues shows a high Asp/Glu content and contains several regions predicted to form amphipathic helices.	Aspartic Acid	125-128	fasciculation and elongation protein zeta 1	Rattus norvegicus	29-72
9974410-2	1999	A point mutation in the encoding region of the methionine synthase gene, which results in substitution of an aspartic acid for a glycine residue (D919G), has been identified in patients of the cblG genetic complementation group; these patients exhibit significantly decreased methionine synthase activity.	Aspartic Acid	109-122	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	47-66
9974410-2	1999	A point mutation in the encoding region of the methionine synthase gene, which results in substitution of an aspartic acid for a glycine residue (D919G), has been identified in patients of the cblG genetic complementation group; these patients exhibit significantly decreased methionine synthase activity.	Aspartic Acid	109-122	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	276-295
10190325-8	1999	These data suggest that a variety of mutations is responsible for decreasing HCS activity and that the aspartate residue at amino acid position 571 may be crucial for the catalytic activity of HCS.	Aspartic Acid	103-112	holocarboxylase synthetase	Homo sapiens	193-196
9929498-7	1999	Our data indicate that Glu, Asp, and Thr in the 7-amino acid sequence of CYP3A4 are critical determinants of selectivity among CYP3A isoforms.	Aspartic Acid	28-31	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	73-79
10091600-6	1999	EGF modules 2, 7 and 8 of the precursor have the consensus sequence for post-translational beta-hydroxylation of Asp/Asn residues.	Aspartic Acid	113-116	epidermal growth factor	Homo sapiens	0-3
9882312-2	1999	The F13L protein contains a variant of the HKD (His-Lys-Asp) motif, which is conserved in numerous enzymes of phospholipid metabolism.	Aspartic Acid	56-59	palmytilated EEV membrane glycoprotein	Vaccinia virus	4-8
10196734-8	1999	The Asp residue that coordinates the adenosyl ribose hydroxyls in NAD(+)-dependent dehydrogenases (including NAD(+)-SDH), was replaced by an Ala in the whitefly NADPH-KR.	Aspartic Acid	4-7	L-iditol 2-dehydrogenase	Ovis aries	116-119
10048577-9	1999	Although several of the inhibitors were effective, z-IETD-FMK was studied most extensively because of its specificity for enzymes which cleave procaspase 3 at aspartate 175 (IETD175).	Aspartic Acid	159-168	caspase 3	Homo sapiens	143-155
9927610-7	1999	The introduction of an Asp in the second transmembrane domain of NTR2 is not enough to restore a functional coupling to G proteins.	Aspartic Acid	23-26	neurotensin receptor 2	Homo sapiens	65-69
9927610-0	1999	Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors.	Aspartic Acid	19-28	neurotensin	Homo sapiens	89-100
9927610-8	1999	In contrast, replacement of Asp113 by Ala residue in NTR1 strongly decreases its ability to activate inositol turnover, indicating that the functionally active conformation of NTR1 is maintained by interaction of sodium ions with aspartate 113.	Aspartic Acid	230-239	neurotensin receptor 1	Homo sapiens	53-57
9927610-1	1999	The highly conserved aspartate residue in the second transmembrane domain of G protein-coupled receptors is present in position 113 in the type 1 neurotensin receptor (NTR1) but is replaced by an Ala residue in position 79 in the type 2 neurotensin receptor (NTR2).	Aspartic Acid	21-30	neurotensin	Homo sapiens	146-157
9927610-1	1999	The highly conserved aspartate residue in the second transmembrane domain of G protein-coupled receptors is present in position 113 in the type 1 neurotensin receptor (NTR1) but is replaced by an Ala residue in position 79 in the type 2 neurotensin receptor (NTR2).	Aspartic Acid	21-30	neurotensin receptor 1	Homo sapiens	168-172
10048930-5	1999	Mutation of Asp 262, located 5.5 A distal to the active site, demonstrates it is essential for catalysis in the high-activity ERK2-dependent conformation of Pyst1 but not for the low-activity ERK2-independent form, suggesting that ERK2 induces closure of the Asp 262 loop over the active site, thereby enhancing Pyst1 catalytic efficiency.	Aspartic Acid	12-15	mitogen-activated protein kinase 1	Homo sapiens	126-130
10048930-5	1999	Mutation of Asp 262, located 5.5 A distal to the active site, demonstrates it is essential for catalysis in the high-activity ERK2-dependent conformation of Pyst1 but not for the low-activity ERK2-independent form, suggesting that ERK2 induces closure of the Asp 262 loop over the active site, thereby enhancing Pyst1 catalytic efficiency.	Aspartic Acid	12-15	dual specificity phosphatase 6	Homo sapiens	157-162
9927610-1	1999	The highly conserved aspartate residue in the second transmembrane domain of G protein-coupled receptors is present in position 113 in the type 1 neurotensin receptor (NTR1) but is replaced by an Ala residue in position 79 in the type 2 neurotensin receptor (NTR2).	Aspartic Acid	21-30	neurotensin	Homo sapiens	237-248
9927610-8	1999	In contrast, replacement of Asp113 by Ala residue in NTR1 strongly decreases its ability to activate inositol turnover, indicating that the functionally active conformation of NTR1 is maintained by interaction of sodium ions with aspartate 113.	Aspartic Acid	230-239	neurotensin receptor 1	Homo sapiens	176-180
9927610-1	1999	The highly conserved aspartate residue in the second transmembrane domain of G protein-coupled receptors is present in position 113 in the type 1 neurotensin receptor (NTR1) but is replaced by an Ala residue in position 79 in the type 2 neurotensin receptor (NTR2).	Aspartic Acid	21-30	neurotensin receptor 2	Homo sapiens	259-263
10048930-5	1999	Mutation of Asp 262, located 5.5 A distal to the active site, demonstrates it is essential for catalysis in the high-activity ERK2-dependent conformation of Pyst1 but not for the low-activity ERK2-independent form, suggesting that ERK2 induces closure of the Asp 262 loop over the active site, thereby enhancing Pyst1 catalytic efficiency.	Aspartic Acid	12-15	dual specificity phosphatase 6	Homo sapiens	312-317
10048930-5	1999	Mutation of Asp 262, located 5.5 A distal to the active site, demonstrates it is essential for catalysis in the high-activity ERK2-dependent conformation of Pyst1 but not for the low-activity ERK2-independent form, suggesting that ERK2 induces closure of the Asp 262 loop over the active site, thereby enhancing Pyst1 catalytic efficiency.	Aspartic Acid	259-262	mitogen-activated protein kinase 1	Homo sapiens	126-130
10048930-5	1999	Mutation of Asp 262, located 5.5 A distal to the active site, demonstrates it is essential for catalysis in the high-activity ERK2-dependent conformation of Pyst1 but not for the low-activity ERK2-independent form, suggesting that ERK2 induces closure of the Asp 262 loop over the active site, thereby enhancing Pyst1 catalytic efficiency.	Aspartic Acid	259-262	dual specificity phosphatase 6	Homo sapiens	157-162
9927610-4	1999	By using site-directed mutagenesis, we substituted Asp113 of the NTR1 by alanine and the homologous residue Ala79 of NTR2 by aspartate.	Aspartic Acid	125-134	neurotensin receptor 2	Homo sapiens	117-121
9927610-6	1999	We demonstrate that the presence of the Asp residue determines by itself the occurrence of the sodium effect on neurotensin affinity for both wild-type and mutated NTR1 and -2.	Aspartic Acid	40-43	neurotensin	Homo sapiens	112-123
9927610-6	1999	We demonstrate that the presence of the Asp residue determines by itself the occurrence of the sodium effect on neurotensin affinity for both wild-type and mutated NTR1 and -2.	Aspartic Acid	40-43	neurotensin receptor 1	Homo sapiens	164-175
10195287-0	1999	Mutation of a highly conserved aspartate residue in subdomain IX abolishes Fer protein-tyrosine kinase activity.	Aspartic Acid	31-40	FER tyrosine kinase	Homo sapiens	75-78
10022353-7	1999	In all the computationally predicted synthetic inhibitor complexes of FXa, the specificity pocket residue Asp-189 is involved in hydrogen bonding with the bound inhibitor.	Aspartic Acid	106-109	coagulation factor X	Homo sapiens	70-73
9952443-7	1999	Asparagine at position 65 of Fd II is a unique residue compared with Fd I and other Fds from various plants, which have aspartic acid or glutamic acid at the corresponding position as an electrostatic interaction site with Fd-NADP+ reductase.	Aspartic Acid	120-133	ferredoxin-2, chloroplastic	Zea mays	29-34
9952443-7	1999	Asparagine at position 65 of Fd II is a unique residue compared with Fd I and other Fds from various plants, which have aspartic acid or glutamic acid at the corresponding position as an electrostatic interaction site with Fd-NADP+ reductase.	Aspartic Acid	120-133	fd I	Zea mays	29-33
10195287-4	1999	In contrast, we show here that conversion of this aspartate to arginine abolished the catalytic activity of the Fer protein-tyrosine kinase when expressed either in mammalian cells or in bacteria.	Aspartic Acid	50-59	FER tyrosine kinase	Homo sapiens	112-115
9873001-0	1999	Mutational analysis of aspartate residues in the transmembrane regions and cytoplasmic loops of rat vesicular acetylcholine transporter.	Aspartic Acid	23-32	solute carrier family 18 member A3	Rattus norvegicus	100-135
9893986-4	1999	In RPTPalpha-D2, the Tyr in the KNRY motif is substituted by Val (position 555) and the Asp in the WpD motif by Glu (position 690).	Aspartic Acid	88-91	protein tyrosine phosphatase receptor type A	Homo sapiens	3-12
9916684-7	1999	That a posttranslational change in amino acid sequence from Asn to Asp alters the repertoire of peptides presented to CD8+ CTL has implications for the design of antiviral vaccines.	Aspartic Acid	67-70	CD8a molecule	Homo sapiens	118-121
9916705-0	1999	Critical requirement for aspartic acid at position 82 of myelin basic protein 73-86 for recruitment of V beta 8.2+ T cells and encephalitogenicity in the Lewis rat.	Aspartic Acid	25-38	myelin basic protein	Rattus norvegicus	57-77
9990288-9	1999	Wild type R2 and threonine-substituted R2 proteins (R2-Thr) were phosphorylated by p34cdc2 kinase, whereas under the same experimental conditions, R2-Asp and R2-Ala phosphorylation was not detected.	Aspartic Acid	150-153	ribonucleotide reductase regulatory subunit M2	Homo sapiens	10-41
9891008-3	1999	Evidence from the TEM-1/BLIP co-crystal suggests that two BLIP residues, Asp-49 and Phe-142, mimic interactions made by penicillin G when bound in the active site of TEM-1.	Aspartic Acid	73-76	hypothetical protein	Escherichia coli	18-23
9891008-3	1999	Evidence from the TEM-1/BLIP co-crystal suggests that two BLIP residues, Asp-49 and Phe-142, mimic interactions made by penicillin G when bound in the active site of TEM-1.	Aspartic Acid	73-76	hypothetical protein	Escherichia coli	166-171
9880491-7	1999	Asp-181 is thought to be involved in Mg2+ binding at the active site (Shen, B., Nolan, J. P., Sklar, L. A., and Park, M. S. (1996) J. Biol.	Aspartic Acid	0-3	mucin 7, secreted	Homo sapiens	37-40
9880491-13	1999	In the absence of magnesium, the FEN-1.34-mer DNA flap complex has an Rg value of approximately 34 A, whereas the D181A.34-mer DNA flap complex self-associates, suggesting that a significant protein conformational change occurs by addition of the flap DNA substrate and that Asp-181 is crucial for proper binding of the protein to the DNA substrate.	Aspartic Acid	275-278	flap structure-specific endonuclease 1	Homo sapiens	33-38
9873064-2	1999	Tumor necrosis factor alpha (TNFalpha) treatment induced a caspase-mediated cleavage of cytosolic, inactive p22 BID at internal Asp sites to yield a major p15 and minor p13 and p11 fragments.	Aspartic Acid	128-131	tumor necrosis factor	Homo sapiens	0-27
9873064-2	1999	Tumor necrosis factor alpha (TNFalpha) treatment induced a caspase-mediated cleavage of cytosolic, inactive p22 BID at internal Asp sites to yield a major p15 and minor p13 and p11 fragments.	Aspartic Acid	128-131	tumor necrosis factor	Homo sapiens	29-37
9873001-2	1999	Rat VAChT has a number of aspartate residues within its predicted transmembrane domains (TM) and cytoplasmic loops, which may play important structural or functional roles in acetylcholine transport.	Aspartic Acid	26-35	solute carrier family 18 member A3	Rattus norvegicus	4-9
9873064-2	1999	Tumor necrosis factor alpha (TNFalpha) treatment induced a caspase-mediated cleavage of cytosolic, inactive p22 BID at internal Asp sites to yield a major p15 and minor p13 and p11 fragments.	Aspartic Acid	128-131	BH3 interacting domain death agonist	Homo sapiens	108-115
9873001-8	1999	Mutation of Asp-193 in TM4 did not affect ACh transport activity; however, vesamicol binding was dramatically reduced.	Aspartic Acid	12-15	tropomyosin 4	Rattus norvegicus	23-26
10641336-3	1999	Pepsinogen, renin, cathepsin E &amp; D and chymosine are typical members of this family, characterised by the presence of aspartic acids boarding the recognition sites.	Aspartic Acid	122-136	renin	Homo sapiens	12-17
10089421-2	1999	Recent biochemical studies have shown that SixA is involved in the signal transduction of the His-Asp phosphorelay through the dephosphorylation of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB.	Aspartic Acid	98-101	hypothetical protein	Escherichia coli	233-237
10641336-3	1999	Pepsinogen, renin, cathepsin E &amp; D and chymosine are typical members of this family, characterised by the presence of aspartic acids boarding the recognition sites.	Aspartic Acid	122-136	cathepsin E	Homo sapiens	19-30
9892210-0	1999	CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis.	Aspartic Acid	143-156	CD44 molecule (Indian blood group)	Homo sapiens	0-4
9895333-1	1999	Hemoglobin J Sardegna [alpha50(CD8)His--&gt;Asn --&gt;Asp] is a human Hb variant in which a posttranslational deamidation process takes place, transforming an Asn to an Asp residue.	Aspartic Acid	54-57	CD8a molecule	Homo sapiens	31-34
9895333-1	1999	Hemoglobin J Sardegna [alpha50(CD8)His--&gt;Asn --&gt;Asp] is a human Hb variant in which a posttranslational deamidation process takes place, transforming an Asn to an Asp residue.	Aspartic Acid	169-172	CD8a molecule	Homo sapiens	31-34
10090430-3	1999	Eptifibatide (Integrilin) is a cyclic heptapeptide inhibitor that contains a modified lysine-glycine-aspartic acid sequence that recognizes the binding site of platelet GP IIb-IIIa, resulting in potent and selective inhibition of its binding to fibrinogen.	Aspartic Acid	101-114	integrin subunit alpha 2b	Homo sapiens	169-175
10327603-4	1999	Pacu insulin contains only two substitutions, Glu--&gt;Asp at A15 and Thr--&gt;Ser at B24 (corresponding to B22 in mammalian insulins) compared with carp insulin.	Aspartic Acid	55-58	insulin	Homo sapiens	5-12
10190023-7	1999	Asparagine or aspartic acid has been reported as the major N-terminal amino acid for thyroglobulins of several animal species whereas glutamic acid is the sole N-terminal amino acid for buffalo thyroglobulin.	Aspartic Acid	14-27	thyroglobulin	Homo sapiens	85-98
10653281-12	1999	Mutagenesis of either of two highly conserved intramembraneous aspartate residues of PS1 leads to reduced Abeta production as observed in the PS1 knockout.	Aspartic Acid	63-72	presenilin 1	Mus musculus	85-88
10449987-4	1999	The levels of glutamate and aspartate increased gradually from birth to the young adult stage, showing peak values at postnatal days (P) 3 and P11.	Aspartic Acid	28-37	S100 calcium binding protein A10 (calpactin)	Mus musculus	143-146
10653281-12	1999	Mutagenesis of either of two highly conserved intramembraneous aspartate residues of PS1 leads to reduced Abeta production as observed in the PS1 knockout.	Aspartic Acid	63-72	amyloid beta (A4) precursor protein	Mus musculus	106-111
10653281-12	1999	Mutagenesis of either of two highly conserved intramembraneous aspartate residues of PS1 leads to reduced Abeta production as observed in the PS1 knockout.	Aspartic Acid	63-72	presenilin 1	Mus musculus	142-145
10331060-4	1999	Because the primary structures of gonadotropin receptors are highly conserved, in vitro mutagenesis was performed to introduce the amino acid substitution in the i3 domain (Asp--&gt;Gly) of FSH receptor, corresponding to the point mutation leading to constitutive activation in LH receptor.	Aspartic Acid	173-176	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	278-289
10320051-10	1999	A further Asp to Tyr polymorphism has been identified at codon 905 of the gene encoding the regulatory subunit of glycogen-associated protein phosphatase-1 (PP1G).	Aspartic Acid	10-13	protein phosphatase 1 catalytic subunit gamma	Mus musculus	157-161
10493260-2	1999	Although CYP2D6 substrates are structurally diverse, most are small molecules that interact with the protein via an electrostatic interaction between a basic nitrogen which is common to the majority of CYP2D6 substrates and an aspartic acid residue in the active site of the protein.	Aspartic Acid	227-240	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	9-15
9887340-3	1999	About one-third of PSACH cases result from heterozygosity for deletion of one codon within a very short triplet repeat, (GAC)5, which encodes five consecutive aspartic acid residues within the calmodulin-like region of the COMP protein.	Aspartic Acid	159-172	cartilage oligomeric matrix protein	Homo sapiens	223-227
10082248-5	1999	Increased aspartate levels were measured in CSF following ACTH therapy (P&lt;0.05).	Aspartic Acid	10-19	proopiomelanocortin	Homo sapiens	58-62
10493260-2	1999	Although CYP2D6 substrates are structurally diverse, most are small molecules that interact with the protein via an electrostatic interaction between a basic nitrogen which is common to the majority of CYP2D6 substrates and an aspartic acid residue in the active site of the protein.	Aspartic Acid	227-240	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	202-208
10319582-7	1999	The SNU-G2 proband harbored a missense mutation from aspartic acid (GAT) to glycine (GGT) at codon 244 in exon 6 of the E-cadherin gene, and the SNU-G1001 proband had a missense mutation from valine (GTG) to alanine (GCG) at codon 487 in exon 10.	Aspartic Acid	53-66	glycine-N-acyltransferase	Homo sapiens	68-71
9880793-5	1999	US-1 had a typical Arg-Gly-Asp (RGD) sequence, which is responsible for blocking the binding of fibrinogen to the receptor.	Aspartic Acid	27-30	fibrinogen beta chain	Homo sapiens	96-106
10319582-7	1999	The SNU-G2 proband harbored a missense mutation from aspartic acid (GAT) to glycine (GGT) at codon 244 in exon 6 of the E-cadherin gene, and the SNU-G1001 proband had a missense mutation from valine (GTG) to alanine (GCG) at codon 487 in exon 10.	Aspartic Acid	53-66	cadherin 1	Homo sapiens	120-130
11624203-11	1999	A molecular study of the neoplastic tissue evidenced a typical mutation of the K-ras gene codon 12:the normal sequence GGT (glycine) was altered into GAT (aspartic acid).	Aspartic Acid	155-168	KRAS proto-oncogene, GTPase	Homo sapiens	79-84
10022481-7	1999	In the presence of aspartate, the fast-positive component was absent from the ERG while the remaining positive-going decay of the receptor potential had a time course similar to that of the slow-positive component in the untreated eye.	Aspartic Acid	19-28	ETS transcription factor ERG	Rattus norvegicus	78-81
10338313-13	1999	The CA1 region of males has a significantly greater concentration of GABA, glutamate and aspartate than females on postnatal day 1.	Aspartic Acid	89-98	carbonic anhydrase 1	Rattus norvegicus	4-7
10780438-2	1999	As a result, peptides with Thr/Glu/His and Gln/Asp were obtained in binding of DNA core and AP2, respectively.	Aspartic Acid	47-50	transcription factor AP-2 alpha	Homo sapiens	92-95
9922164-0	1998	His...Asp catalytic dyad of ribonuclease A: conformational stability of the wild-type, D121N, D121A, and H119A enzymes.	Aspartic Acid	6-9	ribonuclease pancreatic	Bos taurus	28-42
9891983-6	1998	The peptides derived from two regions of N-Vif encompassing residues Tyr-30-Val-65 and Asp-78-Val-98, inhibited PR activity in both the in vitro and the in vivo assays.	Aspartic Acid	87-90	Vif	Human immunodeficiency virus 1	43-46
10022320-2	1998	Two genetic alterations have been identified: the first one is a GGC --&gt; GAT (Gly --&gt; Asp, Asp13p21) mutation at codon 13 in the Ki-ras gene, found in five out of six tumors.	Aspartic Acid	92-95	glycine-N-acyltransferase	Homo sapiens	76-79
9852077-0	1998	Effects of Asp-369 and Arg-372 mutations on heme environment and function in human endothelial nitric-oxide synthase.	Aspartic Acid	11-14	nitric oxide synthase 3	Homo sapiens	83-116
10022320-2	1998	Two genetic alterations have been identified: the first one is a GGC --&gt; GAT (Gly --&gt; Asp, Asp13p21) mutation at codon 13 in the Ki-ras gene, found in five out of six tumors.	Aspartic Acid	92-95	KRAS proto-oncogene, GTPase	Homo sapiens	135-141
9852077-1	1998	Eight polar amino acid residues in the putative substrate-binding region from Thr-360 to Val-379 in human endothelial nitric-oxide synthase (eNOS) (Thr-360, Arg-365, Cys-368, Asp-369, Arg-372, Tyr-373, Glu-377, and Asp-378) were individually mutated.	Aspartic Acid	175-178	nitric oxide synthase 3	Homo sapiens	106-139
9852077-1	1998	Eight polar amino acid residues in the putative substrate-binding region from Thr-360 to Val-379 in human endothelial nitric-oxide synthase (eNOS) (Thr-360, Arg-365, Cys-368, Asp-369, Arg-372, Tyr-373, Glu-377, and Asp-378) were individually mutated.	Aspartic Acid	215-218	nitric oxide synthase 3	Homo sapiens	106-139
9837936-15	1998	The conserved Thr137 in the IC2 was next substituted with proline (T137P) to prevent phosphorylation at this position or with aspartate (T137D) to emulate phosphorylation.	Aspartic Acid	126-135	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	28-31
9841870-7	1998	One contained a premature stop codon at position +81, whereas the second contained a point mutation in the catalytic domain of GlcNAc-TI resulting in the amino acid substitution Gly320--&gt;Asp.	Aspartic Acid	190-193	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Oryctolagus cuniculus	127-136
9841870-8	1998	The introduction of a Gly320--&gt;Asp mutation into wild-type rabbit GlcNAc-TI resulted in a complete loss of activity; the GlcNAc-TI mutant was correctly localized to the Golgi, indicating that the inactive GlcNAc-TI protein was transport-competent.	Aspartic Acid	34-37	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Oryctolagus cuniculus	69-78
9837920-3	1998	We show that binding of JNK to c-Jun in vivo does not require JNK catalytic activity or the presence of the potential phosphoacceptor sites within c-Jun and that JNK retains the capacity to bind to a pseudo-phosphorylated mutant of c-Jun where these sites are replaced by phospho-mimetic aspartic acid residues.	Aspartic Acid	288-301	mitogen-activated protein kinase 8	Homo sapiens	24-27
9837920-3	1998	We show that binding of JNK to c-Jun in vivo does not require JNK catalytic activity or the presence of the potential phosphoacceptor sites within c-Jun and that JNK retains the capacity to bind to a pseudo-phosphorylated mutant of c-Jun where these sites are replaced by phospho-mimetic aspartic acid residues.	Aspartic Acid	288-301	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-36
9914377-0	1998	Interactions between mgr, asp, and polo: asp function modulated by polo and needed to maintain the poles of monopolar and bipolar spindles.	Aspartic Acid	26-29	polo	Drosophila melanogaster	67-71
9830034-2	1998	Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay pathway.	Aspartic Acid	204-207	hypothetical protein	Escherichia coli	53-57
9830034-2	1998	Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay pathway.	Aspartic Acid	204-207	arginine deiminase	Escherichia coli	178-182
9830034-2	1998	Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay pathway.	Aspartic Acid	226-229	hypothetical protein	Escherichia coli	53-57
9830034-2	1998	Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His --&gt; Asp --&gt; His --&gt; Asp phosphorelay pathway.	Aspartic Acid	226-229	arginine deiminase	Escherichia coli	178-182
9830034-5	1998	This reverse phosphorelay involves both the conserved His-717 of the secondary transmitter domain and the conserved Asp-576 of the receiver domain of ArcB but not the conserved His-292 of its primary transmitter domain.	Aspartic Acid	116-119	hypothetical protein	Escherichia coli	150-154
9836590-12	1998	It was concluded from these studies that secretin may be stored in a hexameric form within its secretory tissues and that zinc may play a role in the storage of secretin through a specific interaction with the N-terminal histidine and aspartic acid residues.	Aspartic Acid	235-248	secretin	Homo sapiens	161-169
9914377-0	1998	Interactions between mgr, asp, and polo: asp function modulated by polo and needed to maintain the poles of monopolar and bipolar spindles.	Aspartic Acid	41-44	polo	Drosophila melanogaster	35-39
9914377-0	1998	Interactions between mgr, asp, and polo: asp function modulated by polo and needed to maintain the poles of monopolar and bipolar spindles.	Aspartic Acid	41-44	polo	Drosophila melanogaster	67-71
9845674-3	1998	The cDNA sequence of leptin is normal in KK mice, whereas three nucleotide polymorphisms were found in the cDNA of the leptin receptor, one of them resulting in exchange of an aspartate residue for asparagine (Asp600Asn) in a highly conserved part of the second extracellular cytokine-receptor homology module.	Aspartic Acid	176-185	leptin	Mus musculus	119-125
9834112-8	1998	Both the phagocytosis and production of the cytokines were suppressed by either phospho-L-serine or RGDS (Arg-Gly-Asp-Ser), but not by RGES (Arg-Gly-Glu-Ser).	Aspartic Acid	114-117	ral guanine nucleotide dissociation stimulator	Homo sapiens	100-104
9879917-2	1998	DPP are extremely acidic, rich in aspartic acid and serine, possess a high affinity for calcium and collagen, and are believed to function in dentin mineralization.	Aspartic Acid	34-47	dentin sialophosphoprotein	Homo sapiens	0-3
9879917-5	1998	The open reading frame of this human DPP cDNA comprises 2364 bp encoding 788 amino acids rich in serine (58%), aspartic acid (26%) and asparagine (9%).	Aspartic Acid	111-124	dentin sialophosphoprotein	Homo sapiens	37-40
9813063-4	1998	SAM-9 shares 40, 30, and 29% amino acid identity with potential orthologs, in vaccinia virus, Caenorhabditis elegans, and Dictyostelium discoideum, respectively, and belongs to a subclass of PLD homologs in which the second HXKXXXXD motif is imperfect and harbors a conserved Asp to Glu substitution.	Aspartic Acid	276-279	phospholipase D family, member 3	Mus musculus	0-5
9844921-14	1998	In contrast, changing the critical aspartic acid residues of B-Raf to either tyrosine or phenylalanine increased the frequency of estradiol-responsive cells.	Aspartic Acid	35-48	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	61-66
9849960-2	1998	Many such activating mutations have been identified in transmembrane 6 of the hLHR, with the substitution of Asp-578 being the most frequently observed mutation.	Aspartic Acid	109-112	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	78-82
9930672-1	1998	Variants of human pancreatic carboxypeptidase B (HCPB), with specificity for hydrolysis of C-terminal glutamic acid and aspartic acid, were prepared by site-directed mutagenesis of the human gene and expressed in the periplasm of Escherichia coli.	Aspartic Acid	120-133	carboxypeptidase B1	Homo sapiens	18-47
9806833-5	1998	FKBP23 is a glycoprotein retained in the endoplasmic reticulum by its carboxyl-terminal tetrapeptide His-Asp-Glu-Leu, as demonstrated by immunostaining, retention, and deglycosylation assays.	Aspartic Acid	105-108	FK506 binding protein 7	Mus musculus	0-6
9840926-2	1998	MDM2 is cleaved by Caspase 3 (CPP32) during apoptosis after aspartic acid-361, generating a 60 kd fragment.	Aspartic Acid	60-73	MDM2 proto-oncogene	Homo sapiens	0-4
9840926-2	1998	MDM2 is cleaved by Caspase 3 (CPP32) during apoptosis after aspartic acid-361, generating a 60 kd fragment.	Aspartic Acid	60-73	caspase 3	Homo sapiens	19-28
9840926-2	1998	MDM2 is cleaved by Caspase 3 (CPP32) during apoptosis after aspartic acid-361, generating a 60 kd fragment.	Aspartic Acid	60-73	caspase 3	Homo sapiens	30-35
9817738-5	1998	Site-directed mutagenesis has identified Asp 113 and Ser 204/207 within the third and fourth membrane domains as the active site of the beta2-receptor, critical for beta2-agonist binding and activity.	Aspartic Acid	41-44	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	136-141
9808586-7	1998	Additionally, preincubation of HUVEC with a synthetic peptide Arg-Gly-Asp (RGD) that prevents vWf-mediated adhesion of SS RBC reduced the surface expression of VCAM-1 and NF-kB activation.	Aspartic Acid	70-73	von Willebrand factor	Homo sapiens	94-97
9808586-7	1998	Additionally, preincubation of HUVEC with a synthetic peptide Arg-Gly-Asp (RGD) that prevents vWf-mediated adhesion of SS RBC reduced the surface expression of VCAM-1 and NF-kB activation.	Aspartic Acid	70-73	vascular cell adhesion molecule 1	Homo sapiens	160-166
9792664-1	1998	Aspartate aminotransferase (AspAT) is a unique enzyme that can react with two types of substrate with quite different properties, acidic substrates, such as aspartate and glutamate, and neutral substrates, although the catalytic group Lys-258 acts on both types of substrate.	Aspartic Acid	157-166	aspartate/prephenate aminotransferase	Thermus thermophilus HB8	0-26
9806906-8	1998	Mutation of Glu, Asp or Arg at positions -4, -1 or +1 respectively relative to Tyr1003 in a 9-mer peptide (residues 999-1007) abolished the ability of the peptide to decrease the PTP activity associated with Met.	Aspartic Acid	17-20	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	179-182
9858782-0	1998	Exposure of the cryptic Arg-Gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase.	Aspartic Acid	32-35	thrombospondin 1	Bos taurus	48-64
9858782-0	1998	Exposure of the cryptic Arg-Gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase.	Aspartic Acid	32-35	prolyl 4-hydroxylase subunit beta	Bos taurus	68-95
9858782-3	1998	This interaction is mediated via a cryptic Arg-Gly-Asp sequence in the C-terminal Ca2+-binding region of thrombospondin-1.	Aspartic Acid	51-54	thrombospondin 1	Bos taurus	105-121
9858782-5	1998	Limited reduction of thrombospondin-1 by dithiothreitol exposes the Arg-Gly-Asp sequence which can bind to the alphav beta3 integrin receptor and support endothelial cell spreading (X.	Aspartic Acid	76-79	thrombospondin 1	Bos taurus	21-37
9858782-13	1998	Treatment of thrombospondin-1 with purified protein disulfide isomerase enhanced adhesion of endothelial cells to thrombospondin-1 in an Arg-Gly-Asp-dependent manner through the alphav beta3 integrin receptor and supported cell spreading.	Aspartic Acid	145-148	thrombospondin 1	Bos taurus	13-29
9858782-13	1998	Treatment of thrombospondin-1 with purified protein disulfide isomerase enhanced adhesion of endothelial cells to thrombospondin-1 in an Arg-Gly-Asp-dependent manner through the alphav beta3 integrin receptor and supported cell spreading.	Aspartic Acid	145-148	prolyl 4-hydroxylase subunit beta	Bos taurus	44-71
9858782-13	1998	Treatment of thrombospondin-1 with purified protein disulfide isomerase enhanced adhesion of endothelial cells to thrombospondin-1 in an Arg-Gly-Asp-dependent manner through the alphav beta3 integrin receptor and supported cell spreading.	Aspartic Acid	145-148	thrombospondin 1	Bos taurus	114-130
9858782-15	1998	These results suggest that endothelial cell derived protein disulfide isomerase may regulate Arg-Gly-Asp-dependent binding of thrombospondin-1.	Aspartic Acid	101-104	prolyl 4-hydroxylase subunit beta	Bos taurus	52-79
9858782-15	1998	These results suggest that endothelial cell derived protein disulfide isomerase may regulate Arg-Gly-Asp-dependent binding of thrombospondin-1.	Aspartic Acid	101-104	thrombospondin 1	Bos taurus	126-142
9817738-5	1998	Site-directed mutagenesis has identified Asp 113 and Ser 204/207 within the third and fourth membrane domains as the active site of the beta2-receptor, critical for beta2-agonist binding and activity.	Aspartic Acid	41-44	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	165-170
9988527-3	1998	The peptide containing the sequence Phe-Ser-Trp-Ser-Asp-Trp-Trp-Ser (residues 388-395 in lipoprotein lipase, which include the consensus TSP type I sequence) showed strong binding to heparin.	Aspartic Acid	52-55	lipoprotein lipase	Homo sapiens	89-107
9797363-10	1998	CONCLUSIONS: Deletion at codon 579 (Asp) in the juxtamembrane domain of the c-kit gene is a novel gain-of-function mutation other than the region between Lys-550 and Val-560.	Aspartic Acid	36-39	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	76-81
9832047-6	1998	Direct sequencing of the TIGR/myocilin gene showed a heterozygous A to C transition in codon 380, resulting in the substitution of alanine for aspartic acid (Asp380Ala).	Aspartic Acid	143-156	myocilin	Homo sapiens	25-29
9832047-6	1998	Direct sequencing of the TIGR/myocilin gene showed a heterozygous A to C transition in codon 380, resulting in the substitution of alanine for aspartic acid (Asp380Ala).	Aspartic Acid	143-156	myocilin	Homo sapiens	30-38
9833913-8	1998	We also analyzed the effect of Arg-Gly-Asp containing peptides on the expression of smooth muscle alpha actin by immunocytochemistry and immunoblotting.	Aspartic Acid	39-42	actin alpha 2, smooth muscle	Rattus norvegicus	84-109
9765407-2	1998	We report here the expression of soluble integrin alphav beta5, which retains the ability to recognize the Ad penton base as well as vitronectin, an Arg Gly Asp (RGD)-containing extracellular matrix protein.	Aspartic Acid	157-160	adaptor related protein complex 5 subunit beta 1	Homo sapiens	57-62
9988527-3	1998	The peptide containing the sequence Phe-Ser-Trp-Ser-Asp-Trp-Trp-Ser (residues 388-395 in lipoprotein lipase, which include the consensus TSP type I sequence) showed strong binding to heparin.	Aspartic Acid	52-55	thrombospondin 1	Homo sapiens	137-140
9765407-2	1998	We report here the expression of soluble integrin alphav beta5, which retains the ability to recognize the Ad penton base as well as vitronectin, an Arg Gly Asp (RGD)-containing extracellular matrix protein.	Aspartic Acid	157-160	vitronectin	Homo sapiens	133-144
9750163-1	1998	We studied the roles of Thr-136 (T136) and Glu-137 (E137) in the biogenesis of medium chain acyl-CoA dehydrogenase (MCAD) by altering the former to Ser (T136S), Asp (T136D), or Leu (T136L) and the latter to Asp (E137D), Gln (E137Q), or Lys (E137K).	Aspartic Acid	161-164	acyl-CoA dehydrogenase medium chain	Homo sapiens	116-120
9774654-4	1998	A PI-9 P1 mutant (Glu to Asp) is a 100-fold-less-efficient granzyme B inhibitor that no longer protects against granzyme B-mediated apoptosis.	Aspartic Acid	25-28	serpin family B member 9	Homo sapiens	2-6
9774654-4	1998	A PI-9 P1 mutant (Glu to Asp) is a 100-fold-less-efficient granzyme B inhibitor that no longer protects against granzyme B-mediated apoptosis.	Aspartic Acid	25-28	granzyme B	Homo sapiens	59-69
9774654-4	1998	A PI-9 P1 mutant (Glu to Asp) is a 100-fold-less-efficient granzyme B inhibitor that no longer protects against granzyme B-mediated apoptosis.	Aspartic Acid	25-28	granzyme B	Homo sapiens	112-122
9804611-1	1998	An aspartate-to-alanine point mutation in the catalytic domain (D853A) of guanylyl cyclase-C (GC-C), the heat-stable enterotoxin (STa) receptor, rendered the enzyme catalytically inactive.	Aspartic Acid	3-12	guanylate cyclase 2C	Homo sapiens	74-92
9804611-1	1998	An aspartate-to-alanine point mutation in the catalytic domain (D853A) of guanylyl cyclase-C (GC-C), the heat-stable enterotoxin (STa) receptor, rendered the enzyme catalytically inactive.	Aspartic Acid	3-12	guanylate cyclase 2C	Homo sapiens	94-98
9804611-1	1998	An aspartate-to-alanine point mutation in the catalytic domain (D853A) of guanylyl cyclase-C (GC-C), the heat-stable enterotoxin (STa) receptor, rendered the enzyme catalytically inactive.	Aspartic Acid	3-12	guanylate cyclase 2C	Homo sapiens	105-143
9792179-2	1998	In recent years a growing number of venoms from snakes of Agkistrodon, Bothrops and Trimeresurus species have been shown to contain a catalytically inactive PLA2-homologue in which the highly conserved aspartic acid at position 49 (Asp49) is substituted by lysine (Lys49).	Aspartic Acid	202-215	phospholipase A2 group IIA	Homo sapiens	157-161
9765309-4	1998	Substituting Tyr-272, a proposed binding site for the toxins okadaic acid and microcystin-LR, in the beta12-beta13 loop with Trp, Phe, Asp, Arg, or Ala impaired PP1alpha inhibition by I-1 by 8-10-fold.	Aspartic Acid	135-138	serine/threonine-protein phosphatase PP1-alpha catalytic subunit	Oryctolagus cuniculus	161-169
9756857-2	1998	In this study we provide evidence that glycosylasparaginase (aspartylglucosaminidase), an N-terminal nucleophile hydrolase involved in the hydrolysis of the N-glycosidic bond in glycoproteins, catalyzes the hydrolysis of beta-aspartyl peptides to form L-aspartic acid and amino acids or peptides.	Aspartic Acid	252-267	aspartylglucosaminidase	Homo sapiens	39-59
9750163-1	1998	We studied the roles of Thr-136 (T136) and Glu-137 (E137) in the biogenesis of medium chain acyl-CoA dehydrogenase (MCAD) by altering the former to Ser (T136S), Asp (T136D), or Leu (T136L) and the latter to Asp (E137D), Gln (E137Q), or Lys (E137K).	Aspartic Acid	207-210	acyl-CoA dehydrogenase medium chain	Homo sapiens	79-114
9750163-1	1998	We studied the roles of Thr-136 (T136) and Glu-137 (E137) in the biogenesis of medium chain acyl-CoA dehydrogenase (MCAD) by altering the former to Ser (T136S), Asp (T136D), or Leu (T136L) and the latter to Asp (E137D), Gln (E137Q), or Lys (E137K).	Aspartic Acid	207-210	acyl-CoA dehydrogenase medium chain	Homo sapiens	116-120
9755180-3	1998	A dominant mutation (PNM2 allele) in the SUP35 gene causing a Gly58--&gt;Asp change in the Sup35p N-terminal domain eliminates Psi+.	Aspartic Acid	73-76	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	41-46
9746761-6	1998	Using recombinant caspases and PML/RARalpha deletion mutants we mapped a caspase 3 cleavage site (Asp 522) within the alpha-helix region of the PML component of the fusion protein.	Aspartic Acid	98-101	retinoic acid receptor alpha	Homo sapiens	35-43
9746761-6	1998	Using recombinant caspases and PML/RARalpha deletion mutants we mapped a caspase 3 cleavage site (Asp 522) within the alpha-helix region of the PML component of the fusion protein.	Aspartic Acid	98-101	PML nuclear body scaffold	Homo sapiens	144-147
9746777-2	1998	Three sites on fibrinogen have been hypothesized to be critical for these interactions: the Ala-Gly-Asp-Val (AGDV) sequence at the C-terminus of the gamma chain and two Arg-Gly-Asp (RGD) sequences in the Aalpha chain.	Aspartic Acid	100-103	fibrinogen beta chain	Homo sapiens	15-25
9756722-8	1998	Monoclonal antibody WGH1 reacting with PR3 (a highly positively charged molecule) shows a unique reactive cassette within VHCDR3 with a number of negatively charged aspartic acid residues.	Aspartic Acid	165-178	proteinase 3	Homo sapiens	39-42
9753294-3	1998	The DQB1 homolog in NOD mice, I-Ab(g7), encodes a histidine at codon 56 and a serine at codon 57, while all other known I-Ab alleles encode proline and aspartic acid, respectively, at these positions.	Aspartic Acid	152-165	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-8
9840224-3	1998	Neurotensin (0.2 and 0.5 microM) administered locally through the microdialysis probe to the hippocampus produced a long-lasting and concentration-dependent increase in the basal extracellular levels of GABA and ACh but not of glutamate and aspartate.	Aspartic Acid	241-250	neurotensin	Rattus norvegicus	0-11
9753294-10	1998	Thus, a transgenic class II MHC allele encoding aspartic acid at B57 prevents diabetes, in part, by promoting the production of IL-4 and IL-10, which interfere with the effector phase of the diabetic process.	Aspartic Acid	48-61	interleukin 4	Mus musculus	128-132
9753294-10	1998	Thus, a transgenic class II MHC allele encoding aspartic acid at B57 prevents diabetes, in part, by promoting the production of IL-4 and IL-10, which interfere with the effector phase of the diabetic process.	Aspartic Acid	48-61	interleukin 10	Mus musculus	137-142
10211705-2	1998	Two glycopeptides, GP1 and GP2, prepared from the endoproteinase Asp-N digest of the IgA1 heavy chain, were derived from the CH2 domain (N-glycan site at Asn263) and the tailpiece portion (N-glycan site at Asn459), respectively.	Aspartic Acid	65-68	GTP binding protein 1	Homo sapiens	19-22
10211705-2	1998	Two glycopeptides, GP1 and GP2, prepared from the endoproteinase Asp-N digest of the IgA1 heavy chain, were derived from the CH2 domain (N-glycan site at Asn263) and the tailpiece portion (N-glycan site at Asn459), respectively.	Aspartic Acid	65-68	glycoprotein 2	Homo sapiens	27-30
9801458-4	1998	The amino acid sequences of insulins from R. catesbeiana and R. ridibunda differ by only one residue (Asp for Glu at B21) but R. sylvatica insulin differs from R. catesbeiana insulin at A12 (Thr--&gt;Met), A23 (Asn--&gt;Ser), B5 (Tyr--&gt;His) and B13 (Glu--&gt;Asp).	Aspartic Acid	102-105	insulin	Homo sapiens	28-35
9932648-0	1998	Exogenous ubiquinol analogues affect the fluorescence of NCD-4 bound to aspartate-160 of yeast cytochrome b.	Aspartic Acid	72-81	cytochrome b	Saccharomyces cerevisiae S288C	95-107
9932648-1	1998	Previously, we reported that the carboxyl-reacting reagent DCCD, and its fluorescent derivative NCD-4 binds covalently to aspartate-160 localized in amphipathic helix cd of the CD loop connecting membrane-spanning helices C and D of cytochrome b (Wang et al., 1995).	Aspartic Acid	122-131	cytochrome b	Saccharomyces cerevisiae S288C	233-245
9801458-4	1998	The amino acid sequences of insulins from R. catesbeiana and R. ridibunda differ by only one residue (Asp for Glu at B21) but R. sylvatica insulin differs from R. catesbeiana insulin at A12 (Thr--&gt;Met), A23 (Asn--&gt;Ser), B5 (Tyr--&gt;His) and B13 (Glu--&gt;Asp).	Aspartic Acid	262-265	insulin	Homo sapiens	28-35
9729458-6	1998	With a view to establishing the structural features that might be responsible for these differences in the maturation of pro-PC2 and pro-PC3, Asp310 in pro-PC2 was mutated to Asn, and Asn309 in pro-PC3 was mutated to Asp.	Aspartic Acid	142-145	proprotein convertase subtilisin/kexin type 2	Homo sapiens	125-128
9771895-1	1998	Human class I alcohol dehydrogenase was mutated at positions 57 and 115, exchanging for Asp and Arg respectively, in an attempt to introduce glutathione-dependent formaldehyde dehydrogenase characteristics.	Aspartic Acid	88-91	aldo-keto reductase family 1 member A1	Homo sapiens	14-35
9729458-5	1998	Although highly similar, there are two major differences between pro-PC2 and pro-PC3: the presence of an aspartate at position 310 in pro-PC2 compared with asparagine at the equivalent position in pro-PC3 (and all other members of the subtilisin family), and the N-terminal propeptides, which exhibit low sequence identity (30%).	Aspartic Acid	105-114	proprotein convertase subtilisin/kexin type 2	Homo sapiens	69-72
9771897-0	1998	An Arabidopsis protein that interacts with the cytokinin-inducible response regulator, ARR4, implicated in the His-Asp phosphorylay signal transduction.	Aspartic Acid	115-118	response regulator 4	Arabidopsis thaliana	87-91
9729458-5	1998	Although highly similar, there are two major differences between pro-PC2 and pro-PC3: the presence of an aspartate at position 310 in pro-PC2 compared with asparagine at the equivalent position in pro-PC3 (and all other members of the subtilisin family), and the N-terminal propeptides, which exhibit low sequence identity (30%).	Aspartic Acid	105-114	proprotein convertase subtilisin/kexin type 1	Homo sapiens	81-84
9729458-6	1998	With a view to establishing the structural features that might be responsible for these differences in the maturation of pro-PC2 and pro-PC3, Asp310 in pro-PC2 was mutated to Asn, and Asn309 in pro-PC3 was mutated to Asp.	Aspartic Acid	142-145	proprotein convertase subtilisin/kexin type 1	Homo sapiens	137-140
9729458-5	1998	Although highly similar, there are two major differences between pro-PC2 and pro-PC3: the presence of an aspartate at position 310 in pro-PC2 compared with asparagine at the equivalent position in pro-PC3 (and all other members of the subtilisin family), and the N-terminal propeptides, which exhibit low sequence identity (30%).	Aspartic Acid	105-114	proprotein convertase subtilisin/kexin type 2	Homo sapiens	138-141
9729458-6	1998	With a view to establishing the structural features that might be responsible for these differences in the maturation of pro-PC2 and pro-PC3, Asp310 in pro-PC2 was mutated to Asn, and Asn309 in pro-PC3 was mutated to Asp.	Aspartic Acid	142-145	proprotein convertase subtilisin/kexin type 2	Homo sapiens	156-159
9743343-3	1998	TRAIL-induced death was characterized by caspase activation and cellular protein cleavage within minutes of TRAIL addition, and death could be completely inhibited by the caspase inhibitors Ile-Glu-Thr-Asp (IETD) and Val-Ala-Asp (VAD), indicating the presence of a TRAIL receptor signaling pathway similar to that identified for Fas and TNF receptors.	Aspartic Acid	202-205	TNF superfamily member 10	Homo sapiens	0-5
9743343-3	1998	TRAIL-induced death was characterized by caspase activation and cellular protein cleavage within minutes of TRAIL addition, and death could be completely inhibited by the caspase inhibitors Ile-Glu-Thr-Asp (IETD) and Val-Ala-Asp (VAD), indicating the presence of a TRAIL receptor signaling pathway similar to that identified for Fas and TNF receptors.	Aspartic Acid	202-205	TNF superfamily member 10	Homo sapiens	108-113
9743343-3	1998	TRAIL-induced death was characterized by caspase activation and cellular protein cleavage within minutes of TRAIL addition, and death could be completely inhibited by the caspase inhibitors Ile-Glu-Thr-Asp (IETD) and Val-Ala-Asp (VAD), indicating the presence of a TRAIL receptor signaling pathway similar to that identified for Fas and TNF receptors.	Aspartic Acid	202-205	TNF superfamily member 10	Homo sapiens	108-113
9743589-7	1998	In all four human cell lines tested, expression of a GFP-fused p80 coilin mutant with a single serine to aspartate substitution also caused nucleolar accumulation of splicing snRNPs and coilin, but not ASF/SF2, in structures resembling coiled bodies when viewed by electron microscopy.	Aspartic Acid	105-114	coilin	Homo sapiens	63-66
9780229-8	1998	In order to investigate this further, a series of single and double mutants of CdTnI were used in which either Ala (to direct the enzymatic phosphorylation) or Asp (to mimic the phosphate group) replaced the Ser23 and/or Ser24.	Aspartic Acid	160-163	troponin I3, cardiac type	Canis lupus familiaris	79-84
9737698-4	1998	Moreover, bcl-2 proteins mutated for Asp residues at positions 31 and 34 were efficiently cleaved by RL-7 cell lysates, indicating that this proteolytic activity is distinct from the caspase-3 that cleaves bcl-2 at Asp 34.	Aspartic Acid	37-40	BCL2 apoptosis regulator	Homo sapiens	10-15
9726974-1	1998	In the D171G/D230A mutant generated at conserved aspartate residues in the Exo1 and Exo2 sites of the 3"-5" exonuclease domain of the yeast mitochondrial DNA (mtDNA) polymerase (pol-gamma), the mitochondrial genome is unstable and the frequency of mtDNA point mutations is 1500 times higher than in the wild-type strain and 10 times higher than in single substitution mutants.	Aspartic Acid	49-58	Rad2 family nuclease EXO1	Saccharomyces cerevisiae S288C	75-79
9790785-8	1998	Exons 2 through 11 of the p53 gene were analyzed by direct DNA sequencing, revealing a homozygous mutation at codon 281 in exon 8, GAC to CAC (Asp--&gt;His).	Aspartic Acid	143-146	tumor protein p53	Homo sapiens	26-29
9727075-2	1998	We have previously found that mouse hematopoietic stem cells could be transduced on a FN fragment that included the recognition sequence Arg-Gly-Asp (RGD), suggesting that stem cells may express the integrin very late antigen (VLA)-5.	Aspartic Acid	145-148	fibronectin 1	Mus musculus	86-88
9727075-2	1998	We have previously found that mouse hematopoietic stem cells could be transduced on a FN fragment that included the recognition sequence Arg-Gly-Asp (RGD), suggesting that stem cells may express the integrin very late antigen (VLA)-5.	Aspartic Acid	145-148	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	208-233
9917859-4	1998	Although several enzymes associated with inflammatory tissues are capable of processing proIL-1 beta into an active molecule in the extracellular compartment, the IL-1 beta converting enzyme (ICE, also called caspase-1) cuts intracellular proIL-1 beta after the aspartic acid residue in position 116, resulting in a highly active mature IL-1 beta that is secreted into the extracellular space.	Aspartic Acid	262-275	caspase 1	Homo sapiens	163-190
9917859-4	1998	Although several enzymes associated with inflammatory tissues are capable of processing proIL-1 beta into an active molecule in the extracellular compartment, the IL-1 beta converting enzyme (ICE, also called caspase-1) cuts intracellular proIL-1 beta after the aspartic acid residue in position 116, resulting in a highly active mature IL-1 beta that is secreted into the extracellular space.	Aspartic Acid	262-275	caspase 1	Homo sapiens	192-195
9917859-4	1998	Although several enzymes associated with inflammatory tissues are capable of processing proIL-1 beta into an active molecule in the extracellular compartment, the IL-1 beta converting enzyme (ICE, also called caspase-1) cuts intracellular proIL-1 beta after the aspartic acid residue in position 116, resulting in a highly active mature IL-1 beta that is secreted into the extracellular space.	Aspartic Acid	262-275	caspase 1	Homo sapiens	209-218
9699501-2	1998	BSP possesses an integrin-binding RGD (Arg-Gly-Asp) domain, which may promote interactions between HBC cells and bone extracellular matrix.	Aspartic Acid	47-50	integrin binding sialoprotein	Homo sapiens	0-3
9741688-3	1998	To begin our investigations into the role of the hydrophobic surface in the function of colipase, we replaced three neighboring tyrosine residues at positions 55, 58, and 59 in the hydrophobic surface with aspartic acid.	Aspartic Acid	206-219	colipase	Homo sapiens	88-96
9737698-4	1998	Moreover, bcl-2 proteins mutated for Asp residues at positions 31 and 34 were efficiently cleaved by RL-7 cell lysates, indicating that this proteolytic activity is distinct from the caspase-3 that cleaves bcl-2 at Asp 34.	Aspartic Acid	215-218	BCL2 apoptosis regulator	Homo sapiens	10-15
9724716-7	1998	To disrupt the RI-RNase A interaction, three RNase A residues (Asp-38, Gly-88, and Ala-109) that form multiple contacts with RI were replaced with arginine.	Aspartic Acid	63-66	ribonuclease pancreatic	Bos taurus	45-52
9724716-7	1998	To disrupt the RI-RNase A interaction, three RNase A residues (Asp-38, Gly-88, and Ala-109) that form multiple contacts with RI were replaced with arginine.	Aspartic Acid	63-66	ribonuclease/angiogenin inhibitor 1	Bos taurus	15-17
9698301-3	1998	At normal [K+], aspartate-like and glutamate-like immunoreactivities were colocalized in nerve terminals forming asymmetrical synapses on spines in stratum radiatum of CA1 and the inner molecular layer of fascia dentata (i.e., excitatory afferents from CA3 and hilus, respectively).	Aspartic Acid	16-25	carbonic anhydrase 1	Rattus norvegicus	168-171
9724722-3	1998	The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76.	Aspartic Acid	111-124	collagen type XVIII alpha 1 chain	Homo sapiens	10-20
9796820-5	1998	Molecular modelling studies indicate that this complex could be stabilized by electrostatic interactions involving the glutamate Glu287 and aspartates (Asp290, Asp294, Asp297 and Asp298) of L(281-301)TFIIA and lysine residues (Lys133, Lys138 and Lys145) and arginine residues (Arg137, Arg140) of H2(TBP) in agreement with mutagenesis experiments.	Aspartic Acid	140-150	general transcription factor IIA subunit 1	Homo sapiens	200-205
9796820-5	1998	Molecular modelling studies indicate that this complex could be stabilized by electrostatic interactions involving the glutamate Glu287 and aspartates (Asp290, Asp294, Asp297 and Asp298) of L(281-301)TFIIA and lysine residues (Lys133, Lys138 and Lys145) and arginine residues (Arg137, Arg140) of H2(TBP) in agreement with mutagenesis experiments.	Aspartic Acid	140-150	TATA-box binding protein	Homo sapiens	299-302
9708987-1	1998	Insulin"s natural tendency to form dimers and hexamers is significantly reduced in a mutant insulin B28 Pro --&gt; Asp, which has been designed as a monomeric, rapid-acting hormone for therapeutic purposes.	Aspartic Acid	115-118	insulin	Homo sapiens	0-7
9708987-1	1998	Insulin"s natural tendency to form dimers and hexamers is significantly reduced in a mutant insulin B28 Pro --&gt; Asp, which has been designed as a monomeric, rapid-acting hormone for therapeutic purposes.	Aspartic Acid	115-118	insulin	Homo sapiens	92-99
9708987-1	1998	Insulin"s natural tendency to form dimers and hexamers is significantly reduced in a mutant insulin B28 Pro --&gt; Asp, which has been designed as a monomeric, rapid-acting hormone for therapeutic purposes.	Aspartic Acid	115-118	MIS18 kinetochore protein A	Homo sapiens	100-103
9708987-5	1998	At the monomer-monomer interfaces, the B28 Pro --&gt; Asp mutation leads to increased conformational flexibility in the B chain C termini, resulting in the loss of important intermolecular van der Waals contacts, thus explaining the monomeric character of B28 Asp insulin.	Aspartic Acid	54-57	MIS18 kinetochore protein A	Homo sapiens	39-42
9708987-5	1998	At the monomer-monomer interfaces, the B28 Pro --&gt; Asp mutation leads to increased conformational flexibility in the B chain C termini, resulting in the loss of important intermolecular van der Waals contacts, thus explaining the monomeric character of B28 Asp insulin.	Aspartic Acid	54-57	MIS18 kinetochore protein A	Homo sapiens	256-259
9708987-5	1998	At the monomer-monomer interfaces, the B28 Pro --&gt; Asp mutation leads to increased conformational flexibility in the B chain C termini, resulting in the loss of important intermolecular van der Waals contacts, thus explaining the monomeric character of B28 Asp insulin.	Aspartic Acid	54-57	insulin	Homo sapiens	264-271
9708987-5	1998	At the monomer-monomer interfaces, the B28 Pro --&gt; Asp mutation leads to increased conformational flexibility in the B chain C termini, resulting in the loss of important intermolecular van der Waals contacts, thus explaining the monomeric character of B28 Asp insulin.	Aspartic Acid	260-263	MIS18 kinetochore protein A	Homo sapiens	39-42
9708987-5	1998	At the monomer-monomer interfaces, the B28 Pro --&gt; Asp mutation leads to increased conformational flexibility in the B chain C termini, resulting in the loss of important intermolecular van der Waals contacts, thus explaining the monomeric character of B28 Asp insulin.	Aspartic Acid	260-263	MIS18 kinetochore protein A	Homo sapiens	256-259
9708987-6	1998	The structure of a cross-linked derivative of B28 Asp insulin, containing an Ala-Lys dipeptide linker between residues B30 Ala and A1 Gly, has also determined.	Aspartic Acid	50-53	MIS18 kinetochore protein A	Homo sapiens	46-49
9708987-6	1998	The structure of a cross-linked derivative of B28 Asp insulin, containing an Ala-Lys dipeptide linker between residues B30 Ala and A1 Gly, has also determined.	Aspartic Acid	50-53	insulin	Homo sapiens	54-61
9761475-14	1998	Within the Cys34-Cys42 loop of L-NTP, the structure of the Glu-Glu-Asp-Glu-Glu39 segment appears to be relatively less defined, as is the case for the stretch containing Lys5O within the Cys42-Cys54 segment, consistent with the latter possibly interacting with kringle domains in intact Glul-Pgn.	Aspartic Acid	67-70	glutamate-ammonia ligase	Homo sapiens	287-291
9761475-14	1998	Within the Cys34-Cys42 loop of L-NTP, the structure of the Glu-Glu-Asp-Glu-Glu39 segment appears to be relatively less defined, as is the case for the stretch containing Lys5O within the Cys42-Cys54 segment, consistent with the latter possibly interacting with kringle domains in intact Glul-Pgn.	Aspartic Acid	67-70	plasminogen	Homo sapiens	292-295
9705282-6	1998	Upon incubation of a glycosylatable peptide R-Asn-X-Thr-R" with permeabilized yeast spheroplasts, we detected formation of both glycosylated peptide and the peptide product expected from PNGase-mediated deglycosylation of this glycopeptide, namely, R-Asp-X-Thr-R".	Aspartic Acid	250-254	N-glycanase 1	Homo sapiens	187-193
9698301-8	1998	In hippocampi from animals perfused with glutaraldehyde during insulin-induced hypoglycemia (to combine a strong aspartate signal with good ultrastructure) aspartate was colocalized with glutamate in excitatory terminals in stratum radiatum of CA1.	Aspartic Acid	156-165	carbonic anhydrase 1	Rattus norvegicus	244-247
9694885-3	1998	Both pathways involve the activation of a family of cysteine proteinases, the caspases, that cleave substrates at aspartic acid and are themselves activated by cleavage at internal aspartate residues.	Aspartic Acid	114-127	caspase 8	Homo sapiens	78-86
9694885-3	1998	Both pathways involve the activation of a family of cysteine proteinases, the caspases, that cleave substrates at aspartic acid and are themselves activated by cleavage at internal aspartate residues.	Aspartic Acid	181-190	caspase 8	Homo sapiens	78-86
9683496-4	1998	Results of recent in vitro studies revealed multistep His-to-Asp phosphotransfer circuitry in the ArcB-ArcA signaling system.	Aspartic Acid	61-64	hypothetical protein	Escherichia coli	98-102
9685421-10	1998	Inspection of the human U1 70k protein sequence, comparison with homologues in other animal species, and mutational analysis indicated the importance of the sequence Arg-Arg-Arg-Ser-Arg-Ser-Arg-Asp, which is found repeated twice in the region from Arg248 to Asp270 in the human protein.	Aspartic Acid	194-197	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	24-30
9696767-8	1998	The single guanine-to-adenine transition in upc2-1 gives a predicted amino acid change from glycine to aspartic acid.	Aspartic Acid	103-116	Upc2p	Saccharomyces cerevisiae S288C	44-48
9739087-0	1998	The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.	Aspartic Acid	93-102	enoyl-CoA hydratase 1	Homo sapiens	25-46
11245021-1	1998	OBJECTIVE: To investigate the association of the absence or presence of aspartic acid at position 57 of the HLA-DQ beta chain (NA or A) with susceptibility or resistance to insulin-dependent diabetes mellitus (IDDM) in a Southern Chinese population.	Aspartic Acid	72-85	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	108-111
9683496-4	1998	Results of recent in vitro studies revealed multistep His-to-Asp phosphotransfer circuitry in the ArcB-ArcA signaling system.	Aspartic Acid	61-64	arginine deiminase	Escherichia coli	103-107
9723864-2	1998	To examine further the consequences of the substitution of conserved aspartate 152 on the function of the GH receptor (GHR), we reproduced the mutation in vitro on the full length GH receptor cDNA from man and rat.	Aspartic Acid	69-78	growth hormone receptor	Homo sapiens	119-122
9719034-1	1998	Periodontal ligament (PDL) cells have been shown to express several integrins (alphav, alpha5, beta1, beta3) that use RGD (arginine-glycine-aspartic Acid)-dependent mechanisms for the recognition and binding of their ligands.	Aspartic Acid	140-153	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	102-107
9696750-9	1998	Codisruption of NDH1 and genes encoding malate dehydrogenases essentially eliminates growth on nonfermentable carbon sources, suggesting that the external mitochondrial NADH dehydrogenase and the malate-aspartate shuttle may both contribute to reoxidation of cytosolic NADH under these growth conditions.	Aspartic Acid	203-212	NADH-ubiquinone reductase (H(+)-translocating) NDE1	Saccharomyces cerevisiae S288C	16-20
9723864-2	1998	To examine further the consequences of the substitution of conserved aspartate 152 on the function of the GH receptor (GHR), we reproduced the mutation in vitro on the full length GH receptor cDNA from man and rat.	Aspartic Acid	69-78	growth hormone receptor	Homo sapiens	106-117
9658078-8	1998	The interaction of aspartic acids of ECL2 and TM4 with AMD3100 is consistent with the positive charge of bicyclams, which might block HIV-1 entry by preventing electrostatic interactions between CXCR4 and the HIV-1 envelope protein gp120.	Aspartic Acid	19-33	C-X-C motif chemokine receptor 4	Homo sapiens	195-200
9660884-0	1998	Neutralization of aspartate residues in the murine inwardly rectifying K+ channel IRK1 affects the substate behaviour in Mg2+ block.	Aspartic Acid	18-27	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	82-86
9658078-8	1998	The interaction of aspartic acids of ECL2 and TM4 with AMD3100 is consistent with the positive charge of bicyclams, which might block HIV-1 entry by preventing electrostatic interactions between CXCR4 and the HIV-1 envelope protein gp120.	Aspartic Acid	19-33	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	232-237
9675278-11	1998	In addition, mutation of Ile6 at position P1" either to Val or Asp was deleterious for cathepsin G.	Aspartic Acid	63-66	cathepsin G	Homo sapiens	87-98
9653120-4	1998	Mutagenesis of one of the members of these families, the alpha-1, 3-mannosyltransferase Mnn1p, showed that altering either of these aspartates eliminates all enzymatic activity.	Aspartic Acid	132-142	alpha-1,3-mannosyltransferase MNN1	Saccharomyces cerevisiae S288C	57-93
9669809-16	1998	The types of K-ras mutations in codon 12 were GTT (Val) and GAT (Asp) in each case of hyperplasia; these were identical to those of concomitant carcinomas.	Aspartic Acid	65-68	KRAS proto-oncogene, GTPase	Homo sapiens	13-18
9655873-4	1998	ASP+ accumulation in IHKE-1 cells also was increased by 0.5 mumol/l (20 +/- 8%, n = 8) and 1 mumol/l forskolin (35 +/- 13%, n = 19), and by 8-bromo-cAMP (1 mumol/l, 125 +/- 25%, n = 9), both activators of the cAMP-dependent protein kinase (PKA).	Aspartic Acid	0-4	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	240-243
9683867-9	1998	HLA-DQB1*0301 encodes a negative charge at position DQ 57 (Asp), a critical position in peptide binding to the HLA-DQ molecule groove and therefore we speculate that this molecule may play a role in the selection of BMZ peptides in CP.	Aspartic Acid	59-62	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	0-8
9683867-9	1998	HLA-DQB1*0301 encodes a negative charge at position DQ 57 (Asp), a critical position in peptide binding to the HLA-DQ molecule groove and therefore we speculate that this molecule may play a role in the selection of BMZ peptides in CP.	Aspartic Acid	59-62	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-3
9666148-8	1998	The increase in aspartate and glutamate concentrations that occurs after capsaicin injection was reduced back to baseline after spinal infusion of the PKG inhibitor, KT5823.	Aspartic Acid	16-25	protein kinase cGMP-dependent 1	Homo sapiens	151-154
9730366-7	1998	Amplification of the beta-globin exon 2 and nucleotide sequencing revealed a GAT--&gt;GGT mutation in codon 52 corresponding to an Asp--&gt;Gly replacement.	Aspartic Acid	131-134	glycine-N-acyltransferase	Homo sapiens	77-80
9649305-13	1998	The effect on CpA was unexpected, because the corresponding residue in bovine pancreatic RNase A (Asp-83) hardly affects cytidine-containing substrates.	Aspartic Acid	98-101	ribonuclease pancreatic	Bos taurus	89-96
9658161-10	1998	In VAMP-1B the predicted hydrophobic membrane anchor is shortened by four amino acids, and the hydrophobic sequence is immediately followed by three charged amino acids, arginine-arginine-aspartic acid.	Aspartic Acid	188-201	vesicle associated membrane protein 1	Homo sapiens	3-10
9658205-6	1998	Glutamate and aspartate transport by EAAT1 are associated with an uncoupled chloride conductance, but Zn2+ selectively inhibits transport and increases the relative chloride flux through the transporter.	Aspartic Acid	14-23	solute carrier family 1 member 3	Homo sapiens	37-42
9649305-16	1998	A model, which proposes that the structure of RNase 4 has been optimized to permanently fix the position of Asp-80 and impede its movement away from the pyrimidine binding pocket, is presented.	Aspartic Acid	108-111	ribonuclease A family member 4	Homo sapiens	46-53
9645349-6	1998	Analysis of specific KRAS2 mutations showed a strong effect of Asp (GAT) and Val (GTT) mutations, resulting in a very poor survival compared with wild type group, whereas the most common mutation (Cys, TGT) was not associated with prognosis.	Aspartic Acid	63-66	KRAS proto-oncogene, GTPase	Homo sapiens	21-26
9636030-0	1998	His...Asp catalytic dyad of ribonuclease A: structure and function of the wild-type, D121N, and D121A enzymes.	Aspartic Acid	6-9	ribonuclease pancreatic	Bos taurus	28-42
9636030-3	1998	In bovine pancreatic ribonuclease A (RNase A), the His...Asp dyad is composed of His119 and Asp121.	Aspartic Acid	57-60	ribonuclease pancreatic	Bos taurus	21-35
9636030-3	1998	In bovine pancreatic ribonuclease A (RNase A), the His...Asp dyad is composed of His119 and Asp121.	Aspartic Acid	57-60	ribonuclease pancreatic	Bos taurus	37-44
9636039-6	1998	In contrast, mutation of Ser-563--&gt;Asp preserved HSL hydrolytic activity and even increased activity 20% above the control wild-type enzyme.	Aspartic Acid	38-41	lipase E, hormone sensitive type	Rattus norvegicus	52-55
9624170-5	1998	Significantly, we demonstrate that substitution of the nonpolar glycine residue for either or both of the conserved negatively charged aspartic acid residues at positions 174 and 175 in the full-length recombinant Nef protein background completely abrogated binding of c-Raf1 in vitro.	Aspartic Acid	135-148	S100 calcium binding protein B	Homo sapiens	214-217
9624170-5	1998	Significantly, we demonstrate that substitution of the nonpolar glycine residue for either or both of the conserved negatively charged aspartic acid residues at positions 174 and 175 in the full-length recombinant Nef protein background completely abrogated binding of c-Raf1 in vitro.	Aspartic Acid	135-148	TNF receptor associated factor 3	Homo sapiens	269-275
9712171-6	1998	To test this hypothesis, the role of two conserved residues in the sixth transmembrane domain of the AT2 receptor in ligand binding were investigated: tryptophan 269 and aspartate 279.	Aspartic Acid	170-179	angiotensin II receptor type 2	Homo sapiens	101-104
9636140-4	1998	This report demonstrates that tyrosine phosphorylation of paxillin and FAK elicited by stimulation of muscarinic m3 receptors with the acetylcholine analog carbachol is inhibited by soluble peptides containing the arginine-glycine-aspartate motif (the recognition site for integrins found in adhesion proteins such as fibronectin) but is unaffected by peptides containing the inactive sequence arginine-glycine-glutamate.	Aspartic Acid	231-240	protein tyrosine kinase 2	Homo sapiens	71-74
9636140-4	1998	This report demonstrates that tyrosine phosphorylation of paxillin and FAK elicited by stimulation of muscarinic m3 receptors with the acetylcholine analog carbachol is inhibited by soluble peptides containing the arginine-glycine-aspartate motif (the recognition site for integrins found in adhesion proteins such as fibronectin) but is unaffected by peptides containing the inactive sequence arginine-glycine-glutamate.	Aspartic Acid	231-240	fibronectin 1	Homo sapiens	318-329
9645349-6	1998	Analysis of specific KRAS2 mutations showed a strong effect of Asp (GAT) and Val (GTT) mutations, resulting in a very poor survival compared with wild type group, whereas the most common mutation (Cys, TGT) was not associated with prognosis.	Aspartic Acid	63-66	glycine-N-acyltransferase	Homo sapiens	68-71
9614108-4	1998	Conversion of Asp-187 to a neutral residue exclusively unmasked activity with M-tropic Env in fusion and infection experiments.	Aspartic Acid	14-17	endogenous retrovirus group K member 20	Homo sapiens	87-90
9614240-9	1998	In vivo application of the irreversible caspase inhibitor benzyloxycarbonyl-Asp-Glu-Val-Asp-chloromethylketone revealed CPP32-like proteases to be major mediators of caspase-induced apoptosis in axotomized RGCs, because this inhibitor showed an even higher neuroprotective potential than the irreversible wide-range inhibitor benzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketone.	Aspartic Acid	76-79	caspase 3	Rattus norvegicus	120-125
9637483-4	1998	We designed, genetically constructed, and expressed a receptor site-specific IL-15 antagonist by mutating glutamine residues within the C terminus of IL-15 to aspartic acid and genetically linked this mutant IL-15 to murine Fc gamma2a.	Aspartic Acid	159-172	interleukin 15	Mus musculus	77-82
9614108-6	1998	The independence of CXCR4 coreceptor activity from charged residues and the extension of its repertoire by removing Asp-187 suggest that this interaction is not electrostatic and that coreceptors have the potential to be utilized by a spectrum of Env, which may be masked by charged amino acids in extracellular domains.	Aspartic Acid	116-119	endogenous retrovirus group K member 20	Homo sapiens	247-250
9637483-4	1998	We designed, genetically constructed, and expressed a receptor site-specific IL-15 antagonist by mutating glutamine residues within the C terminus of IL-15 to aspartic acid and genetically linked this mutant IL-15 to murine Fc gamma2a.	Aspartic Acid	159-172	interleukin 15	Mus musculus	150-155
9637483-4	1998	We designed, genetically constructed, and expressed a receptor site-specific IL-15 antagonist by mutating glutamine residues within the C terminus of IL-15 to aspartic acid and genetically linked this mutant IL-15 to murine Fc gamma2a.	Aspartic Acid	159-172	interleukin 15	Mus musculus	150-155
9681597-1	1998	Given that aminopeptidase A is primarily responsible for cleaving aspartic acid and converting angiotensin II to angiotensin III, the purpose of the present study was to evaluate the activity of aminopeptidase A by determination of glutamate aminopeptidase activity (GluAP) and aspartate aminopeptidase activity (AspAP) (reported respectively as aminopeptidase A and angiotensinase A activities) in human serum during development and ageing, in an apparently healthy population of 139 male and 148 female subjects.	Aspartic Acid	66-79	glutamyl aminopeptidase	Homo sapiens	11-27
9622496-0	1998	Discriminatory influence of Glu-376--&gt;Asp mutation in medium-chain acyl-CoA dehydrogenase on the binding of selected CoA-ligands: spectroscopic, thermodynamic, kinetic, and model building studies.	Aspartic Acid	41-44	acyl-CoA dehydrogenase medium chain	Homo sapiens	57-92
9655832-14	1998	Secondly, architectural differences in the CD loops of MAdCAM-1 and VCAM-1 cause an 8 A shift in position of the critical aspartate residue, and may partly determine their binding preference for different integrins.	Aspartic Acid	122-131	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	55-63
9655832-14	1998	Secondly, architectural differences in the CD loops of MAdCAM-1 and VCAM-1 cause an 8 A shift in position of the critical aspartate residue, and may partly determine their binding preference for different integrins.	Aspartic Acid	122-131	vascular cell adhesion molecule 1	Homo sapiens	68-74
9622498-2	1998	This protein is a mutant resulting from the dimeric wild-type CoLE1-ROP protein by deletion of 5 amino acids (Asp 30, Ala 31, Asp 32, Glu 33, Gln 34) in the loop of each monomer.	Aspartic Acid	110-113	opsin 1, long wave sensitive	Homo sapiens	68-71
9622498-2	1998	This protein is a mutant resulting from the dimeric wild-type CoLE1-ROP protein by deletion of 5 amino acids (Asp 30, Ala 31, Asp 32, Glu 33, Gln 34) in the loop of each monomer.	Aspartic Acid	126-129	opsin 1, long wave sensitive	Homo sapiens	68-71
9681597-1	1998	Given that aminopeptidase A is primarily responsible for cleaving aspartic acid and converting angiotensin II to angiotensin III, the purpose of the present study was to evaluate the activity of aminopeptidase A by determination of glutamate aminopeptidase activity (GluAP) and aspartate aminopeptidase activity (AspAP) (reported respectively as aminopeptidase A and angiotensinase A activities) in human serum during development and ageing, in an apparently healthy population of 139 male and 148 female subjects.	Aspartic Acid	66-79	glutamyl aminopeptidase	Homo sapiens	195-211
9681597-1	1998	Given that aminopeptidase A is primarily responsible for cleaving aspartic acid and converting angiotensin II to angiotensin III, the purpose of the present study was to evaluate the activity of aminopeptidase A by determination of glutamate aminopeptidase activity (GluAP) and aspartate aminopeptidase activity (AspAP) (reported respectively as aminopeptidase A and angiotensinase A activities) in human serum during development and ageing, in an apparently healthy population of 139 male and 148 female subjects.	Aspartic Acid	66-79	carboxypeptidase Q	Homo sapiens	11-25
9603909-5	1998	The same mutations performed in the DXDST motif of L-3-phosphoserine phosphatase also resulted in complete inactivation of the enzyme, except for the replacement of the second aspartate by glutamate, which reduced the activity by only about 40%.	Aspartic Acid	176-185	phosphoserine phosphatase	Homo sapiens	51-80
9681597-1	1998	Given that aminopeptidase A is primarily responsible for cleaving aspartic acid and converting angiotensin II to angiotensin III, the purpose of the present study was to evaluate the activity of aminopeptidase A by determination of glutamate aminopeptidase activity (GluAP) and aspartate aminopeptidase activity (AspAP) (reported respectively as aminopeptidase A and angiotensinase A activities) in human serum during development and ageing, in an apparently healthy population of 139 male and 148 female subjects.	Aspartic Acid	66-79	carboxypeptidase Q	Homo sapiens	195-209
9603909-6	1998	This suggests that the first aspartate of the motif is also the phosphorylated residue in L-3-phosphoserine phosphatase.	Aspartic Acid	29-38	phosphoserine phosphatase	Homo sapiens	90-119
9681597-1	1998	Given that aminopeptidase A is primarily responsible for cleaving aspartic acid and converting angiotensin II to angiotensin III, the purpose of the present study was to evaluate the activity of aminopeptidase A by determination of glutamate aminopeptidase activity (GluAP) and aspartate aminopeptidase activity (AspAP) (reported respectively as aminopeptidase A and angiotensinase A activities) in human serum during development and ageing, in an apparently healthy population of 139 male and 148 female subjects.	Aspartic Acid	66-79	glutamyl aminopeptidase	Homo sapiens	195-211
9651578-4	1998	Apaf-1-mediated processing of procaspase-9 occurs at Asp-315 by an intrinsic autocatalytic activity of procaspase-9 itself.	Aspartic Acid	53-56	apoptotic peptidase activating factor 1	Homo sapiens	0-6
9618439-4	1998	Also, coating either form of the purified GP IIb/IIIa onto yttrium silicate scintillation proximity assay fluomicrospheres produced an activated form of the receptor, whose binding affinity for GP IIb/IIIa antagonists was measured conveniently by competition with the arginine-glycine-aspartic acid (RGD) containing heptapeptide [125I]L-692,884.	Aspartic Acid	285-298	integrin subunit alpha 2b	Homo sapiens	42-48
9618439-4	1998	Also, coating either form of the purified GP IIb/IIIa onto yttrium silicate scintillation proximity assay fluomicrospheres produced an activated form of the receptor, whose binding affinity for GP IIb/IIIa antagonists was measured conveniently by competition with the arginine-glycine-aspartic acid (RGD) containing heptapeptide [125I]L-692,884.	Aspartic Acid	285-298	integrin subunit alpha 2b	Homo sapiens	194-200
9611168-5	1998	Phenotypic analysis of the aat2 and aat3 mutants revealed a dramatic aspartate-related phenotype in one of the mutants deficient in cytosolic AAT2.	Aspartic Acid	69-78	aspartate aminotransferase 2	Arabidopsis thaliana	27-31
9611168-5	1998	Phenotypic analysis of the aat2 and aat3 mutants revealed a dramatic aspartate-related phenotype in one of the mutants deficient in cytosolic AAT2.	Aspartic Acid	69-78	aspartate aminotransferase 5	Arabidopsis thaliana	36-40
9611168-5	1998	Phenotypic analysis of the aat2 and aat3 mutants revealed a dramatic aspartate-related phenotype in one of the mutants deficient in cytosolic AAT2.	Aspartic Acid	69-78	aspartate aminotransferase 2	Arabidopsis thaliana	142-146
9611168-6	1998	The aat2-2 mutant displays an 80% reduction in levels of aspartate transported in the phloem of light-grown plants, and a 50% reduction in levels of asparagine transported in dark-adapted plants.	Aspartic Acid	57-66	aspartate aminotransferase 2	Arabidopsis thaliana	4-8
9611168-7	1998	These results indicate that cytosolic AAT2 is the major isoenzyme controlling aspartate synthesized for nitrogen transport in the light, and that this aspartate pool is converted to asparagine when plants are dark adapted.	Aspartic Acid	78-87	aspartate aminotransferase 2	Arabidopsis thaliana	38-42
9611168-7	1998	These results indicate that cytosolic AAT2 is the major isoenzyme controlling aspartate synthesized for nitrogen transport in the light, and that this aspartate pool is converted to asparagine when plants are dark adapted.	Aspartic Acid	151-160	aspartate aminotransferase 2	Arabidopsis thaliana	38-42
9618260-0	1998	Intracellular retention and degradation of tissue-nonspecific alkaline phosphatase with a Gly317--&gt;Asp substitution associated with lethal hypophosphatasia.	Aspartic Acid	102-105	alkaline phosphatase, biomineralization associated	Homo sapiens	43-82
9585419-1	1998	The amyloid-beta peptide (Abeta) can mediate cell attachment by binding to beta1 integrins through an arg-his-asp sequence.	Aspartic Acid	110-113	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	75-80
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Aspartic Acid	58-61	CART prepropeptide	Mus musculus	19-23
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Aspartic Acid	58-61	CART prepropeptide	Mus musculus	62-66
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Aspartic Acid	58-61	CART prepropeptide	Mus musculus	62-66
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Aspartic Acid	214-217	H1.0 linker histone	Homo sapiens	120-125
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Aspartic Acid	214-217	H1.0 linker histone	Homo sapiens	120-125
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Aspartic Acid	214-217	H1.0 linker histone	Homo sapiens	120-125
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Aspartic Acid	214-217	H1.0 linker histone	Homo sapiens	120-125
9582379-6	1998	Edman degradation of the N-terminal H1(0) peptide fragments and mass spectra analysis have indicated that human histone H1(0) consists of intact histones H1(0) (named H1(0) Asn-3) and deamidated H1(0) forms (H1(0) Asp-3) having an aspartic acid residue at position 3 instead of asparagine.	Aspartic Acid	214-217	H1.0 linker histone	Homo sapiens	120-125
9570797-1	1998	We examined the expression, activation, and cellular localization of caspase-3 (CPP32) using immunohistochemistry, immunoblots, and cleavage of the fluorogenic substrate N-benzyloxycarbonyl-Asp-Glu-Val-Asp-7-amino-4-trifluoromethyl coumarin (zDEVD-afc) in adult mouse brain after temporary (2 hr) middle cerebral artery occlusion produced by filament insertion into the carotid artery.	Aspartic Acid	202-205	caspase 3	Mus musculus	69-78
9570797-1	1998	We examined the expression, activation, and cellular localization of caspase-3 (CPP32) using immunohistochemistry, immunoblots, and cleavage of the fluorogenic substrate N-benzyloxycarbonyl-Asp-Glu-Val-Asp-7-amino-4-trifluoromethyl coumarin (zDEVD-afc) in adult mouse brain after temporary (2 hr) middle cerebral artery occlusion produced by filament insertion into the carotid artery.	Aspartic Acid	202-205	caspase 3	Mus musculus	80-85
9581827-0	1998	The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor.	Aspartic Acid	73-82	estrogen receptor 1	Homo sapiens	91-108
9607306-2	1998	Putative proteins (ATRR1-4) contain a receiver domain with a conserved aspartate residue - a possible phosphorylation site - at the N-terminal half.	Aspartic Acid	71-80	response regulator 4	Arabidopsis thaliana	19-26
9565551-2	1998	The spectroscopic properties of the mutant enzymes are altered and become similar to those of tryptophanase and aspartate aminotransferase, enzymes in which an Asp residue interacts with the pyridine nitrogen of pyridoxal phosphate.	Aspartic Acid	160-163	tryptophan 2,3-dioxygenase	Homo sapiens	94-107
9579578-2	1998	It showed a 30 bp deletion at the carboxyl terminus with specific amino acid substitution Asp at codon 335 with reference to Gly in B95-8 LMP1.	Aspartic Acid	90-93	PDZ and LIM domain 7	Homo sapiens	138-142
9705090-5	1998	p35 cleavage was inhibited by mutating the active site aspartic acid to alanine, and by a panel of protease inhibitors that inhibit caspase-3-like proteases, including iodoacetamide, N-ethylmaleimide, and Ac-DEVD-cho.	Aspartic Acid	55-68	interleukin 12a	Mus musculus	0-3
9651535-11	1998	This difference results from a single amino acid substitution, aspartate of mGluR1 or threonine of mGluR5, at the G protein-interacting carboxy-terminal domains.	Aspartic Acid	63-72	glutamate metabotropic receptor 1	Homo sapiens	76-82
9651535-11	1998	This difference results from a single amino acid substitution, aspartate of mGluR1 or threonine of mGluR5, at the G protein-interacting carboxy-terminal domains.	Aspartic Acid	63-72	glutamate receptor, ionotropic, kainate 1	Mus musculus	99-105
9610778-1	1998	Polymerase chain reaction (PCR) amplification of specific alleles allowed the rapid detection of a point mutation (missense Gly528 --&gt; Asp) in exon 11 of the low density lipoprotein receptor gene which was otherwise not detectable by exon amplification and enzymatic digestion as it does not modify the normal restriction pattern.	Aspartic Acid	138-141	low density lipoprotein receptor	Homo sapiens	161-193
9580609-0	1998	Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling.	Aspartic Acid	31-40	cannabinoid receptor 1	Homo sapiens	114-117
9580609-0	1998	Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling.	Aspartic Acid	31-40	cannabinoid receptor 2	Homo sapiens	122-125
9580609-4	1998	Aspartate 163 (in CB1) and aspartate 80 (in CB2) were substituted with either asparagine or glutamate.	Aspartic Acid	0-9	cannabinoid receptor 1	Homo sapiens	18-21
9766188-3	1998	Two unrelated individuals with Hb Osler have been recently reinvestigated at the DNA level and surprisingly, in their beta gene, codon 145 was found to be AAT which encodes for asparagine and not for aspartic acid, the aspartate at the protein level resulting, thus, from a very efficient posttranslational event.	Aspartic Acid	219-228	serpin family A member 1	Homo sapiens	155-158
9766188-4	1998	We reinvestigated a patient from the family of Hb Nancy and found that codon 145 was GAT, encoding for aspartate.	Aspartic Acid	103-112	glycine-N-acyltransferase	Homo sapiens	85-88
9566918-7	1998	Substitution of the Ser-Thr sites with the phosphomimetic Asp generated a constitutively active form of IRF-3 that functioned as a very strong activator of promoters containing PRDI-PRDIII or ISRE regulatory elements.	Aspartic Acid	58-61	interferon regulatory factor 3	Homo sapiens	104-109
9596642-7	1998	Site-directed mutagenesis defined two highly conserved amino acids, cysteine-265 and aspartate-234, as being essential for the phosphatase activity of the AtPTP1 protein, suggesting a common catalytic mechanism for PTPases from all eukaryotic systems.	Aspartic Acid	85-94	protein tyrosine phosphatase 1	Arabidopsis thaliana	155-161
9531562-2	1998	The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils.	Aspartic Acid	147-150	fibronectin 1	Homo sapiens	19-30
9553075-10	1998	The mutation of aspartates 657 and 659 to asparagines in C2B decreased Ca2+-dependent and increased Ca2+-independent vesicle binding, indicating the Ca2+ dependence of the domain is provided by aspartic acid residues in the putative Ca2+-binding pocket.	Aspartic Acid	16-26	secretoglobin family 2B member 3, pseudogene	Homo sapiens	57-60
9553075-10	1998	The mutation of aspartates 657 and 659 to asparagines in C2B decreased Ca2+-dependent and increased Ca2+-independent vesicle binding, indicating the Ca2+ dependence of the domain is provided by aspartic acid residues in the putative Ca2+-binding pocket.	Aspartic Acid	194-207	secretoglobin family 2B member 3, pseudogene	Homo sapiens	57-60
9587406-0	1998	Dicyclohexylcarbodiimide inhibits proton pumping in ubiquinol:cytochrome c oxidoreductase of Rhodobacter sphaeroides and binds to aspartate-187 of cytochrome b.	Aspartic Acid	130-139	cytochrome b	Saccharomyces cerevisiae S288C	147-159
9587406-3	1998	Radioactive DCCD is bound exclusively to cytochrome b at aspartate-187, which is located at the C-terminal region of the CD loop connecting membrane-spanning helices C and D of cytochrome b.	Aspartic Acid	57-66	cytochrome b	Saccharomyces cerevisiae S288C	41-53
9587406-3	1998	Radioactive DCCD is bound exclusively to cytochrome b at aspartate-187, which is located at the C-terminal region of the CD loop connecting membrane-spanning helices C and D of cytochrome b.	Aspartic Acid	57-66	cytochrome b	Saccharomyces cerevisiae S288C	177-189
9587407-4	1998	Another, termed cystatin SA2, carries two amino acid substitutions (59Gly--&gt;Asp; 120Glu--&gt;Asp), one of which is in the so-called QXVXG region (the first hairpin loop) and another in the C-terminal portion of the molecule.	Aspartic Acid	79-82	probable cystatin-15	Bos taurus	16-24
9587407-4	1998	Another, termed cystatin SA2, carries two amino acid substitutions (59Gly--&gt;Asp; 120Glu--&gt;Asp), one of which is in the so-called QXVXG region (the first hairpin loop) and another in the C-terminal portion of the molecule.	Aspartic Acid	79-82	stromal antigen 2	Homo sapiens	25-28
9587407-4	1998	Another, termed cystatin SA2, carries two amino acid substitutions (59Gly--&gt;Asp; 120Glu--&gt;Asp), one of which is in the so-called QXVXG region (the first hairpin loop) and another in the C-terminal portion of the molecule.	Aspartic Acid	96-99	probable cystatin-15	Bos taurus	16-24
9587407-4	1998	Another, termed cystatin SA2, carries two amino acid substitutions (59Gly--&gt;Asp; 120Glu--&gt;Asp), one of which is in the so-called QXVXG region (the first hairpin loop) and another in the C-terminal portion of the molecule.	Aspartic Acid	96-99	stromal antigen 2	Homo sapiens	25-28
9602025-1	1998	Based on circular dichroism (CD), we have found an essential (i, i + 4) alpha-helix stabilizing array in the C-terminus region for the cholesteryl ester transfer protein (CETP) between histidine 466 and aspartic acid 470.	Aspartic Acid	203-216	cholesteryl ester transfer protein	Homo sapiens	135-169
9602025-1	1998	Based on circular dichroism (CD), we have found an essential (i, i + 4) alpha-helix stabilizing array in the C-terminus region for the cholesteryl ester transfer protein (CETP) between histidine 466 and aspartic acid 470.	Aspartic Acid	203-216	cholesteryl ester transfer protein	Homo sapiens	171-175
9535836-3	1998	In one case, substitution of Asp at the end of complement control protein repeat (CCP) 2 with an Asn transformed the protein, with negligible cofactor activity and iC3 binding, into a mutant with activities similar to native CR1.	Aspartic Acid	29-32	AGBL carboxypeptidase 2	Homo sapiens	47-88
9531562-2	1998	The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils.	Aspartic Acid	147-150	fibronectin 1	Homo sapiens	169-180
9531562-2	1998	The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils.	Aspartic Acid	147-150	fibronectin 1	Homo sapiens	169-180
9531562-2	1998	The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils.	Aspartic Acid	147-150	fibronectin 1	Homo sapiens	169-180
9538022-1	1998	This report describes the expression, purification, and characterization of a series of recombinant factor Xa variants bearing aspartate substitutions for each of the glutamate residues which normally undergo gamma-carboxylation.	Aspartic Acid	127-136	coagulation factor X	Homo sapiens	100-109
9538013-7	1998	Extensive digestion of SSAO enzymes, and of porcine kidney diamine oxidase, with pronase E yielded species with identical chromophoric properties characteristic of the dipeptide, TPQ(p-NPH)-Asp.	Aspartic Acid	190-193	amine oxidase copper containing 2	Homo sapiens	23-27
9538013-7	1998	Extensive digestion of SSAO enzymes, and of porcine kidney diamine oxidase, with pronase E yielded species with identical chromophoric properties characteristic of the dipeptide, TPQ(p-NPH)-Asp.	Aspartic Acid	190-193	amine oxidase copper containing 1	Homo sapiens	59-74
9535892-1	1998	Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13.	Aspartic Acid	25-38	GTPase-activating protein SEC13	Saccharomyces cerevisiae S288C	82-87
9535892-9	1998	We mutated each of these conserved Asp residues to Gly individually and in pairs in Gbeta and in Sec13, a yeast WD repeat protein involved in vesicular traffic, and then analyzed the ability of the mutant proteins to fold in vitro and in COS-7 cells.	Aspartic Acid	35-38	GTPase-activating protein SEC13	Saccharomyces cerevisiae S288C	97-102
9535892-15	1998	Mutations of the conserved Asp in Sec13 affect folding equally in vitro and in COS-7 cells.	Aspartic Acid	27-30	GTPase-activating protein SEC13	Saccharomyces cerevisiae S288C	34-39
9521733-0	1998	Catalysis in human hypoxanthine-guanine phosphoribosyltransferase: Asp 137 acts as a general acid/base.	Aspartic Acid	67-70	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	19-65
9512488-4	1998	Additional mutations of NaDC-1 at position 106 showed that aspartic acid and asparagine, but not arginine, can substitute for histidine.	Aspartic Acid	59-72	solute carrier family 13 member 2	Oryctolagus cuniculus	24-30
9524113-3	1998	Comparison of wild-type versus K18 Ser33--&gt;Ala/Asp transfected cells showed that K18 Ser33 phosphorylation is essential for the association of K18 with 14-3-3 proteins, and plays a role in keratin organization and distribution.	Aspartic Acid	50-53	keratin 18	Homo sapiens	84-87
9524113-3	1998	Comparison of wild-type versus K18 Ser33--&gt;Ala/Asp transfected cells showed that K18 Ser33 phosphorylation is essential for the association of K18 with 14-3-3 proteins, and plays a role in keratin organization and distribution.	Aspartic Acid	50-53	keratin 18	Homo sapiens	84-87
9531309-5	1998	In contrast, activity of caspase 1 (IL-1beta-converting enzyme)-like proteases (Tyr-Val-Ala-Asp-substrate) did not change throughout the experiment.	Aspartic Acid	92-95	caspase 1	Mus musculus	25-34
9516482-3	1998	In the present study, we analyzed the effects of mutating the Glu at position 31 of the c-Ha-Ras protein to Asp, Ala, Arg, and Lys on the interactions with Raf-1 and RalGDS.	Aspartic Acid	108-111	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	156-161
9516482-3	1998	In the present study, we analyzed the effects of mutating the Glu at position 31 of the c-Ha-Ras protein to Asp, Ala, Arg, and Lys on the interactions with Raf-1 and RalGDS.	Aspartic Acid	108-111	ral guanine nucleotide dissociation stimulator	Homo sapiens	166-172
9578463-1	1998	Interleukin-1beta-converting enzyme is a member of a family of human cysteine proteases with specificity for aspartic acid, which have been named caspases.	Aspartic Acid	109-122	caspase 1	Homo sapiens	0-35
9578463-1	1998	Interleukin-1beta-converting enzyme is a member of a family of human cysteine proteases with specificity for aspartic acid, which have been named caspases.	Aspartic Acid	109-122	caspase 1	Homo sapiens	146-154
9578981-1	1998	The neuroendocrine peptides cholecystokinin (CCK) and gastrin, originally identified in mammals, are characterized by a common amidated C-terminal tetrapeptide sequence, Trp-Met-Asp-Phe.NH2, which also constitutes the minimal structure necessary for biological activity of both.	Aspartic Acid	178-181	cholecystokinin	Homo sapiens	45-48
9578981-1	1998	The neuroendocrine peptides cholecystokinin (CCK) and gastrin, originally identified in mammals, are characterized by a common amidated C-terminal tetrapeptide sequence, Trp-Met-Asp-Phe.NH2, which also constitutes the minimal structure necessary for biological activity of both.	Aspartic Acid	178-181	gastrin	Homo sapiens	54-61
9587070-8	1998	Analysis of the LPL gene revealed an Asn 291--&gt;Ser mutation in three patients and a -93 T-G substitution combined with an Asp 9--&gt;Asn mutation in one control subject.	Aspartic Acid	125-128	lipoprotein lipase	Homo sapiens	16-19
9490687-8	1998	Arg517 is part of the Arg-Gly-Asp(RGD) sequence in thrombin and contributes to an ion cluster with aspartic acid residues 552 and 554.	Aspartic Acid	30-33	coagulation factor II, thrombin	Homo sapiens	51-59
9501077-3	1998	We propose that upon proteolysis, the amino-terminal end of the capsid refolds into a beta-hairpin/helix structure that is stabilized by formation of a salt bridge between the processed amino-terminus (Pro1) and a highly conserved aspartate residue (Asp51).	Aspartic Acid	231-240	lamin A/C	Homo sapiens	202-206
9600632-0	1998	Preferential blockade of cholecystokinin-8S-induced increases in aspartate and glutamate levels by the CCK(B) receptor antagonist, L-365,260, in rat brain.	Aspartic Acid	65-74	cholecystokinin B receptor	Rattus norvegicus	103-118
9600632-1	1998	In the present studies, the ability of a locally delivered cholecystokinin (CCK) receptor agonist and systemically delivered antagonists to modulate extracellular levels of aspartate and glutamate in the frontal cortex of anaesthetised rats and frontal cortex and caudate-putamen of freely moving rats was investigated using an in vivo microdialysis technique.	Aspartic Acid	173-182	cholecystokinin	Rattus norvegicus	76-79
9600632-2	1998	In the anaesthetised rats, local application of sulphated CCK octapeptide (CCK-8S, 10 microM) into the frontal cortex enhanced extracellular aspartate levels to a maximum of 265+/-16% of the basal levels, whereas glutamate levels were increased to a maximum of 168+/-7% of the basal levels.	Aspartic Acid	141-150	cholecystokinin	Rattus norvegicus	58-61
9600632-2	1998	In the anaesthetised rats, local application of sulphated CCK octapeptide (CCK-8S, 10 microM) into the frontal cortex enhanced extracellular aspartate levels to a maximum of 265+/-16% of the basal levels, whereas glutamate levels were increased to a maximum of 168+/-7% of the basal levels.	Aspartic Acid	141-150	cholecystokinin	Rattus norvegicus	75-78
9490687-8	1998	Arg517 is part of the Arg-Gly-Asp(RGD) sequence in thrombin and contributes to an ion cluster with aspartic acid residues 552 and 554.	Aspartic Acid	99-112	coagulation factor II, thrombin	Homo sapiens	51-59
9600632-3	1998	Given 40 min prior to the cortical perfusion of 10 microM of CCK-8S, the CCK(B) receptor antagonist, L-365,260 (20 mg/kg, s.c.), limited the rise in cortical aspartate by over half to 170+/-10% of the basal levels.	Aspartic Acid	158-167	cholecystokinin B receptor	Rattus norvegicus	73-88
9600632-6	1998	In the freely moving rats, local perfusion of CCK-8S (10 microM) increased aspartate and glutamate levels to maxima of 275+/-12% and 225+/-14% of the basal levels, respectively, in the frontal cortex.	Aspartic Acid	75-84	cholecystokinin	Rattus norvegicus	46-49
9490688-6	1998	The active site in doubly-wound alpha/beta folds forms a crevice that is located at the switch point between the two halves of the central beta-sheet, and usually contains two metal-binding Asp residues in the vWF-A superfamily.	Aspartic Acid	190-193	von Willebrand factor	Homo sapiens	210-213
9600632-7	1998	In the caudate-putamen, aspartate and glutamate levels were also elevated by CCK-8S (10 microM) to 248+/-15% and 185+/-12% of the basal levels, respectively.	Aspartic Acid	24-33	cholecystokinin	Rattus norvegicus	77-80
9600632-8	1998	The respective increase in aspartate and glutamate induced by CCK-8S (10 microM) were limited to 140+/-10% and 124+/-6% (frontal cortex), of the basal levels, and 162+/-15% and 143+/-8% (caudate-putamen), by 40 min pretreatment with L-365,260 (20 mg/kg, s.c.).	Aspartic Acid	27-36	cholecystokinin	Rattus norvegicus	62-65
9600632-9	1998	In conclusion, CCK-8S was able to enhance both aspartate and glutamate overflow in the frontal cortex of anaesthetised rats, and frontal cortex and caudate-putamen of freely moving rats.	Aspartic Acid	47-56	cholecystokinin	Rattus norvegicus	15-18
9593602-1	1998	The histamine H1 receptor has an aspartate (Asp) residue in transmembrane helix 3 (TM3), which is well-conserved among biogenic amine receptors.	Aspartic Acid	33-42	histamine receptor H1	Homo sapiens	4-25
9593602-1	1998	The histamine H1 receptor has an aspartate (Asp) residue in transmembrane helix 3 (TM3), which is well-conserved among biogenic amine receptors.	Aspartic Acid	44-47	histamine receptor H1	Homo sapiens	4-25
9593602-7	1998	These results demonstrate that the tested tri- and tetracyclic histamine H1 receptor antagonists which have a tight interaction with the Asp residue are not selective for the histamine H1 receptor.	Aspartic Acid	137-140	histamine receptor H1	Homo sapiens	63-84
9593602-8	1998	Furthermore, the high selectivity of KW-4679 might be explained by a unique binding pocket, which consists of the Asp residue and other acceptor sites, in the histamine H1 receptor.	Aspartic Acid	114-117	histamine receptor H1	Homo sapiens	159-180
9521537-1	1998	A recent study demonstrated both an extrinsic and an intrinsic calretinin (CR) innervation of the rat septal complex and that a population of the extrinsic calretinin fibers is aspartate/glutamate-containing.	Aspartic Acid	177-186	calbindin 2	Rattus norvegicus	156-166
9508791-0	1998	Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae.	Aspartic Acid	76-87	Dip5p	Saccharomyces cerevisiae S288C	0-5
9508791-3	1998	Deletion of a gene denoted DIP5 results in the loss of L-aspartate and L-glutamate uptake.	Aspartic Acid	55-66	Dip5p	Saccharomyces cerevisiae S288C	27-31
9508791-5	1998	DIP5-dependent uptake of L-aspartate and L-glutamate was somewhat lower in ammonium-grown cells than in proline-grown cells.	Aspartic Acid	25-36	Dip5p	Saccharomyces cerevisiae S288C	0-4
9508791-9	1998	Our results suggest that DIP5 encodes an amino-acid permease with a high transport capacity and a high affinity for L-glutamate and L-aspartate, with a Kt of about 50 microM for both.	Aspartic Acid	132-143	Dip5p	Saccharomyces cerevisiae S288C	25-29
9568289-5	1998	Further structure-activity relationship studies at each position of the peptide sequence suggest a novel motif sequence, Pro-X1-X2-X3-Asp-X4, for specific GpIIb/IIIa integrin recognition, in which the N-terminal free Pro residue and the Asp residue at the fifth position are essential to the activity.	Aspartic Acid	134-137	integrin subunit alpha 2b	Homo sapiens	155-160
9568289-5	1998	Further structure-activity relationship studies at each position of the peptide sequence suggest a novel motif sequence, Pro-X1-X2-X3-Asp-X4, for specific GpIIb/IIIa integrin recognition, in which the N-terminal free Pro residue and the Asp residue at the fifth position are essential to the activity.	Aspartic Acid	237-240	integrin subunit alpha 2b	Homo sapiens	155-160
9541598-4	1998	MMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity, indicating that MMCP-8, similar to granzyme B, preferentially cleaves after Asp residues.	Aspartic Acid	210-213	mast cell protease 8	Mus musculus	0-6
9501140-4	1998	The activity of ME increased greater than 6-fold early in hypoxia, and then declined coincident with depletion of cytosolic malate and aspartate. We found that in respiring root tips, anaplerotic phosphoenolpyruvate carboxylase activity was high relative to ME, and therefore did not limit synthesis of pyruvate by ME. The significance of in vivo pyruvate synthesis by ME is discussed with respect to malate and pyruvate utilization by isolated mitochondria and intracellular pH regulation under hypoxia.	Aspartic Acid	136-145	NADP-dependent malic enzyme	Zea mays	17-19
9541598-4	1998	MMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity, indicating that MMCP-8, similar to granzyme B, preferentially cleaves after Asp residues.	Aspartic Acid	210-213	granzyme B	Mus musculus	51-61
9541598-4	1998	MMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity, indicating that MMCP-8, similar to granzyme B, preferentially cleaves after Asp residues.	Aspartic Acid	210-213	mast cell protease 8	Mus musculus	150-156
9521257-1	1998	Fatal familial insomnia (FFI) is an inherited prion disease linked to a mutation at codon 178 of the PRNP gene that results in aspartic acid to asparagine substitution, in coupling phase with methionine at position 129.	Aspartic Acid	127-140	prion protein	Homo sapiens	101-105
9498770-3	1998	Further examination of the three-dimensional structure in this region revealed conformational differences between human and murine beta2m that affect the ability of an aspartic acid residue at position 53 (D53) conserved in both beta 2ms to form an ionic bond with arginine residues at positions 35 and 48 of the heavy chain.	Aspartic Acid	168-181	beta-2 microglobulin	Mus musculus	131-137
9498770-3	1998	Further examination of the three-dimensional structure in this region revealed conformational differences between human and murine beta2m that affect the ability of an aspartic acid residue at position 53 (D53) conserved in both beta 2ms to form an ionic bond with arginine residues at positions 35 and 48 of the heavy chain.	Aspartic Acid	168-181	hemoglobin, beta adult minor chain	Mus musculus	229-235
9587916-4	1998	Analysis of [3H]D-Asp uptake kinetics indicates that CORT reduced the maximum uptake rate in cultured astrocyte, but not in neurons, after cyanide exposure.	Aspartic Acid	18-21	cortistatin	Rattus norvegicus	53-57
9501134-1	1998	In this paper we report our study of the metabolic regulation of expression of an Arabidopsis aspartate kinase/homoserine dehydrogenase (AK/HSD) gene, which encodes two linked key enzymes in the biosynthetic pathway of aspartate family amino acids.	Aspartic Acid	95-104	aspartate kinase-homoserine dehydrogenase ii	Arabidopsis thaliana	138-144
9484780-8	1998	The Shb PTB domain was found to preferentially bind the sequence Asp-Asp-X-pTyr when incubated with a phosphopeptide library.	Aspartic Acid	65-68	SH2 domain containing adaptor protein B	Homo sapiens	4-7
9468476-0	1998	Substitution of transducin ser202 by asp abolishes G-protein/RGS interaction.	Aspartic Acid	37-40	paired like homeodomain 2	Homo sapiens	61-64
9468476-7	1998	The Ser202 --&gt; Asp mutation abolished Gtalpha recognition by hRGSr.	Aspartic Acid	18-21	integrin subunit alpha 2b	Homo sapiens	41-48
9541395-4	1998	Mutations at any of the four catalytic amino acids His 134, His 252, Glu 78, and Asp 212 drastically reduced the hydrolytic activity of DNase I.	Aspartic Acid	81-84	deoxyribonuclease 1	Homo sapiens	136-143
9478999-6	1998	Another mutant with Ser942 --&gt; Asp was able to associate with the membrane, although at a decreased level, indicating that the dissociation of p115 from the membrane is not simply due to the negative charge of phosphorylated Ser942.	Aspartic Acid	34-37	USO1 vesicle transport factor	Homo sapiens	146-150
9461487-0	1998	Mutagenesis of the aspartic acid ligands in human serum transferrin: lobe-lobe interaction and conformation as revealed by antibody, receptor-binding and iron-release studies.	Aspartic Acid	19-32	transferrin	Homo sapiens	56-67
9512712-6	1998	However, Pro67--&gt;Asp and Glu mutations promote constitutive cleavage of LexA and reduce induction of UmuD cleavage to just 5 to 10% of wild-type activity.	Aspartic Acid	20-23	DNA repair system	Escherichia coli	75-79
9512712-6	1998	However, Pro67--&gt;Asp and Glu mutations promote constitutive cleavage of LexA and reduce induction of UmuD cleavage to just 5 to 10% of wild-type activity.	Aspartic Acid	20-23	UmuD	Escherichia coli	104-108
9484241-0	1998	Influence of excision of a methylene group from Glu-376 (Glu376--&gt;Asp mutation) in the medium chain acyl-CoA dehydrogenase-catalyzed reaction.	Aspartic Acid	69-72	acyl-CoA dehydrogenase medium chain	Homo sapiens	90-125
9461518-7	1998	Na+-dependent aspartate transport in H4 hepatoma cells was mediated by a high-affinity system (Km 5 microM) and was inhibited by D-aspartate and L-glutamate but not by d-glutamate-properties characteristic of the high-affinity glutamate transporter EAAC1.	Aspartic Acid	14-23	solute carrier family 1 member 1	Rattus norvegicus	249-254
9480772-2	1998	To obtain insight into the origin of the specificity, the binding to aspartyl-tRNA synthetase (AspRS) of the negatively charged substrate aspartic acid and the neutral analogue asparagine are compared by use of molecular dynamics and free energy simulations.	Aspartic Acid	138-151	aspartyl-tRNA synthetase 1	Homo sapiens	69-93
9498811-1	1998	Inducible expression of the mammalian glial cell glutamate transporter GLT-1 has been established in a CHO cell line selected for low endogenous Na+-dependent glutamate uptake by [3H]aspartate suicide selection.	Aspartic Acid	183-192	solute carrier family 1 member 2	Homo sapiens	71-76
9452427-7	1998	Additionally, peptides containing Leu, Asp, or Ala at the +1 position are phosphorylated with similar efficiencies by CaMKIV, whereas the Leu-substituted peptide is preferred by CaMKIIalpha (by a factor of 5.8-9.7-fold).	Aspartic Acid	39-42	calcium/calmodulin dependent protein kinase IV	Homo sapiens	118-124
9498811-2	1998	Culturing the cells in doxycycline-containing medium, to activate GLT-1 expression via the Tet-On system, increased uptake of the GLT-1 substrate D-aspartate 280-fold, and increased cell size.	Aspartic Acid	148-157	solute carrier family 1 member 2	Homo sapiens	130-135
9480772-2	1998	To obtain insight into the origin of the specificity, the binding to aspartyl-tRNA synthetase (AspRS) of the negatively charged substrate aspartic acid and the neutral analogue asparagine are compared by use of molecular dynamics and free energy simulations.	Aspartic Acid	138-151	aspartyl-tRNA synthetase 1	Homo sapiens	95-100
9480772-3	1998	Simulations of the Asn-AspRS complex show that although Asn cannot bind in the same position as Asp, several possible positions exist 1.5 to 2 A away from the Asp site.	Aspartic Acid	96-99	aspartyl-tRNA synthetase 1	Homo sapiens	23-28
9466564-1	1998	During apoptosis, activation of a family of cysteine proteases related to interleukin-1beta-converting enzyme (ICE)-related proteases or "caspases" results in endoproteolytic cleavage of multiple substrates at specific aspartate residues.	Aspartic Acid	219-228	caspase 1	Homo sapiens	111-114
9532792-3	1998	These findings indicate that the reaction of renin with angiotensinogen involves at least two amino acid residues other than the two aspartic acid residues known to be involved and occurs at acidic pH and basic pH by two different pairs of these amino acid residues.	Aspartic Acid	133-146	renin	Homo sapiens	45-50
9486170-12	1998	We conclude that the labeling of aspartate in apoB-100 provides a good estimate of the isotopomer distribution in hepatic oxaloacetate but may underestimate the absolute isotopic enrichment by 50%.	Aspartic Acid	33-42	apolipoprotein B	Sus scrofa	46-54
9532792-3	1998	These findings indicate that the reaction of renin with angiotensinogen involves at least two amino acid residues other than the two aspartic acid residues known to be involved and occurs at acidic pH and basic pH by two different pairs of these amino acid residues.	Aspartic Acid	133-146	angiotensinogen	Homo sapiens	56-71
9449632-8	1998	The aspartate and glutamate mutants had no intrinsic agonist activity, but both antagonized the growth-promoting activity of wild-type PRL, with the aspartate mutant proving to be a very effective antagonist.	Aspartic Acid	4-13	prolactin	Homo sapiens	135-138
9449632-8	1998	The aspartate and glutamate mutants had no intrinsic agonist activity, but both antagonized the growth-promoting activity of wild-type PRL, with the aspartate mutant proving to be a very effective antagonist.	Aspartic Acid	149-158	prolactin	Homo sapiens	135-138
9449632-2	1998	In this study our aim was to produce a molecular mimic of phosphorylated PRL by substituting a fairly bulky, negatively charged amino acid (glutamate or aspartate) for the normally phosphorylated serine [serine 179 in human PRL (hPRL)].	Aspartic Acid	153-162	prolactin	Homo sapiens	73-76
9449632-9	1998	Two hundred picograms per ml of the aspartate mutant negated 75% of the growth response to 400 pg/ml wild-type PRL.	Aspartic Acid	36-45	prolactin	Homo sapiens	111-114
9449632-12	1998	The aspartate mutant can now be used to study many aspects of the physiology of PRL.	Aspartic Acid	4-13	prolactin	Homo sapiens	80-83
9446613-8	1998	In other work, deletion analysis led to the assignment of two domains in Atp12p; the functional domain of the protein was mapped to the sequence between Gln-181 and Val-306, and a structural domain (Asp-307 through Gln-325) was identified that confers Atp12p the ability to oligomerize with other proteins in mitochondria.	Aspartic Acid	199-202	ATP synthase complex assembly protein ATP12	Saccharomyces cerevisiae S288C	73-79
9489669-0	1998	An Escherichia coli protein that exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay.	Aspartic Acid	152-155	hypothetical protein	Escherichia coli	110-114
9489669-1	1998	The Escherichia coli sensory kinase, ArcB, possesses a histidine-containing phosphotransfer (HPt) domain, which is implicated in the His-Asp multistep phosphorelay.	Aspartic Acid	137-140	hypothetical protein	Escherichia coli	37-41
9430708-0	1998	A high affinity glutamate/aspartate transport system in pancreatic islets of Langerhans modulates glucose-stimulated insulin secretion.	Aspartic Acid	26-35	insulin	Homo sapiens	117-124
9442050-0	1998	The crucial roles of Asp-314 and Thr-315 in the catalytic activation of molecular oxygen by neuronal nitric-oxide synthase.	Aspartic Acid	21-24	nitric oxide synthase 2	Homo sapiens	101-122
9427712-3	1998	Caspase-1 belongs to a rapidly growing family of cysteine proteases with substrate specificity for aspartate involved in cellular apoptosis.	Aspartic Acid	99-108	caspase 1	Homo sapiens	0-9
9425017-7	1998	c-Junasp, a constitutively active c-Jun mutant in which the known and potential serine and threonine phosphoacceptor sites in the transactivation domain have been mutated to aspartic acid, induces apoptosis under all conditions tested.	Aspartic Acid	174-187	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
9427724-11	1998	Apparently, the 60Ala--&gt;Asp substitution in SH-Fc gamma RIIIb influences the epitope recognized by PEN1.	Aspartic Acid	27-30	Fc gamma receptor IIIb	Homo sapiens	50-64
9543249-7	1998	Phospholipase A2 inhibition with 7,7-dimethyleicosadienoic acid (DEDA, 2 microM) reduced osmotically-evoked releases of taurine, aspartate and glutamate.	Aspartic Acid	129-138	phospholipase A2 group IB	Rattus norvegicus	0-16
9435301-7	1998	ERK2 activation could be blocked with a combination of anti-alpha4 and -alpha5 antibodies and an arginine-glycine-aspartic acid (RGD) peptide, while the antibodies or peptide used separately failed to block ERK2 activation.	Aspartic Acid	114-127	mitogen activated protein kinase 1	Rattus norvegicus	0-4
9422782-6	1998	Site-directed mutagenesis of pro-PC2 further showed that a single residue replacement in the catalytic domain, Tyr-194 --&gt; Asp, prevented pro-PC2 from binding 7B2 and blocked activation.	Aspartic Acid	126-129	proprotein convertase subtilisin/kexin type 2	Mus musculus	33-36
9422782-6	1998	Site-directed mutagenesis of pro-PC2 further showed that a single residue replacement in the catalytic domain, Tyr-194 --&gt; Asp, prevented pro-PC2 from binding 7B2 and blocked activation.	Aspartic Acid	126-129	proprotein convertase subtilisin/kexin type 2	Mus musculus	145-148
9422782-6	1998	Site-directed mutagenesis of pro-PC2 further showed that a single residue replacement in the catalytic domain, Tyr-194 --&gt; Asp, prevented pro-PC2 from binding 7B2 and blocked activation.	Aspartic Acid	126-129	secretogranin V	Mus musculus	162-165
9505804-13	1998	Treatment of cows with bovine somatotropin resulted in changes in mammary parameter estimates for aspartate, glutamate, leucine, phenylalanine, glucose, and glycerol.	Aspartic Acid	98-107	somatotropin	Bos taurus	30-42
9871461-6	1998	Dopamine (DA) and cholecystokinin (CCK) selectively stimulate Asp release, via D1 and CCKB receptor subtypes, respectively.	Aspartic Acid	62-65	cholecystokinin	Rattus norvegicus	35-38
9603236-14	1998	A new polyacidic amino acid motif composed of consecutive Asp and Glu residues (n &gt; 7) was defined in extracellular matrix components osteopontin, bone sialoprotein, and bone acidic glycoprotein-75 on the basis of strong functional analogies with similar polyacidic stretches in divalent metal storage proteins of the endoplasmic reticulum and sarcoplasmic reticulum.	Aspartic Acid	58-61	tyrosinase related protein 1	Homo sapiens	185-200
10520751-6	1998	HM-1 contains no obvious hydrophobic N-terminal cleavable signal sequence, and no potential N-glycosylation sites, but does contain three highly conserved motifs present in U1-70K splicing factors, and contains numerous C-terminal Arg/Asp and Arg/Glu dipeptides characteristic of "RD" family members that function as regulators of mRNA splicing.	Aspartic Acid	235-238	small nuclear ribonucleoprotein U11/U12 subunit 35	Homo sapiens	0-4
9554754-11	1998	We suggest that the existence of three pathological amino acid substitutions for aspartic acid 695 most likely reflects the essential role of this residue for normal androgen receptor function in male sexual differentiation.	Aspartic Acid	81-94	androgen receptor	Homo sapiens	166-183
9541227-4	1998	Dentin phosphoprotein (DPP) is rich in aspartic acid (D) and phosphoserine (S*) and binds large amounts of calcium.	Aspartic Acid	39-52	dentin sialophosphoprotein	Homo sapiens	0-21
9541227-4	1998	Dentin phosphoprotein (DPP) is rich in aspartic acid (D) and phosphoserine (S*) and binds large amounts of calcium.	Aspartic Acid	39-52	dentin sialophosphoprotein	Homo sapiens	23-26
9541227-8	1998	Dentin sialoprotein (DSP), found only in dentin, is a 53 kDa glycoprotein rich in aspartic acid, serine, glutamic acid and glycine.	Aspartic Acid	82-95	dentin sialophosphoprotein	Homo sapiens	0-19
9541229-8	1998	DMP3 is not a typical Asp-rich phosphophoryn, but DMP2 contains a domain N-terminal to the common region which has the hallmark Asp- and Ser-rich composition of the phosphophoryns.	Aspartic Acid	128-131	dentin matrix protein 2	Mus musculus	50-54
9421404-0	1998	Substitution of Ala564 in the first zinc cluster of the deoxyribonucleic acid (DNA)-binding domain of the androgen receptor by Asp, Asn, or Leu exerts differential effects on DNA binding.	Aspartic Acid	127-130	androgen receptor	Homo sapiens	106-123
9421404-1	1998	In the androgen receptor of a patient with androgen insensitivity, the alanine residue at position 564 in the first zinc cluster of the DNA-binding domain was substituted by aspartic acid.	Aspartic Acid	174-187	androgen receptor	Homo sapiens	7-24
10215405-8	1998	The patient was also revealed to be homozygous for a novel missense point mutation D203A, changing codon 203 (GAC) encoding Asp to GCC encoding Ala in the StAR gene.	Aspartic Acid	124-127	steroidogenic acute regulatory protein	Homo sapiens	155-159
10627132-5	1998	One family was found in which members carried a novel p16 allele with a G to T transversion at position 451, creating a missense amino acid change at codon 145 (Asp to Cys) and possibly disrupting the donor splice site of the exon 2/3 boundary.	Aspartic Acid	161-164	cyclin dependent kinase inhibitor 2A	Homo sapiens	54-57
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Aspartic Acid	54-57	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Aspartic Acid	54-57	interleukin 1 beta	Homo sapiens	139-147
9600199-4	1998	Tissues were immunostained using affinity-purified polyclonal antibodies specific for the L-aspartate residue of Abeta at position one (AbetaN1[D]), D-aspartate at N1 (AbetaN1[rD]), and pyroglutamate at N3 (AbetaN3[pE]) and p3, a peptide beginning with leucine at N17 (AbetaN17[L]).	Aspartic Acid	90-101	amyloid beta precursor protein	Homo sapiens	113-118
9460938-1	1998	Mutants of tobacco vein mottling virus (TVMV) with substitutions of Lys or Arg for Asp in the DAG motif at position 5 in the coat protein (CP) failed to infect tobacco plants systemically, but replicated and produced virions in protoplasts.	Aspartic Acid	83-86	golgi phosphoprotein 3	Homo sapiens	125-137
9460938-4	1998	Tobacco etch virus (TEV) mutants with substitutions of Lys for Asp in the two DAG motifs near the CP N terminus also failed to infect tobacco plants systemically, and in situ histochemical analysis showed limited movement.	Aspartic Acid	63-66	carboxypeptidase N subunit 1	Homo sapiens	98-102
10806846-3	1998	The results showed that the three richest amino acids in HSP70 of all origins were Gly, Glu and Asp, except that of rat heart which was rich in Gly, Phe and Glu.	Aspartic Acid	96-99	heat shock protein family A (Hsp70) member 4	Rattus norvegicus	57-62
9481670-10	1998	Substitutions of glycine, serine, glutamine or aspartate for the N-site asparagine in the NR1-subunit enhanced the extent of block over intermediate potentials but left the voltage dependence of the block unchanged indicating that structural determinants of the block remained.	Aspartic Acid	47-56	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	90-93
9420225-3	1998	Here, we use site-directed, alanine-scanning mutagenesis of CCR5 to show that substitutions of the negatively charged aspartic acid residues at positions 2 and 11 (D2A and D11A) and a glutamic acid residue at position 18 (E18A), individually or in combination, impair or abolish CCR5-mediated HIV-1 entry for the ADA and JR-FL M-tropic strains and the DH123 dual-tropic strain.	Aspartic Acid	118-131	C-C motif chemokine receptor 5	Homo sapiens	60-64
9664622-6	1998	The transport activity observed following express of dEAAT in Xenopus oocytes or COS-7 cells shows a high affinity for L-glutamate, L-aspartate and D-aspartate, an absolute dependence on external sodium ions, and considerable stereoselectivity for the transport of L-glutamate over D-glutamate.	Aspartic Acid	132-143	Excitatory amino acid transporter 1	Drosophila melanogaster	53-58
9514274-3	1998	A conserved side chain, Asp 26, which is sterically accessible to the active site, is also essential to oxidoreductase activity.	Aspartic Acid	24-27	oxidoreductase	Escherichia coli	104-118
9459502-3	1998	Because *0807 has been observed only in South American populations, we propose that it was generated from a parental *0802 allele recently, after the isolation of various Native South American populations, and infer that the DRB1*0807 allele was generated by a C to T change at codon 57 (Asp--&gt;Val, GAT--&gt;GTT) from the ancestral *0802.	Aspartic Acid	288-291	major histocompatibility complex, class II, DR beta 1	Homo sapiens	225-229
9769701-4	1998	Previous studies demonstrated that mutation of a conserved aspartate residue in the alpha 2AAR to asparagine (D79N alpha 2AAR) resulted in a receptor that retained its ability to inhibit voltage-gated Ca2+ channels and cAMP production but was unable to activate K+ currents in AtT20 cells (Surprenant et al., 1992).	Aspartic Acid	59-68	adrenergic receptor, alpha 2a	Mus musculus	84-94
9769701-4	1998	Previous studies demonstrated that mutation of a conserved aspartate residue in the alpha 2AAR to asparagine (D79N alpha 2AAR) resulted in a receptor that retained its ability to inhibit voltage-gated Ca2+ channels and cAMP production but was unable to activate K+ currents in AtT20 cells (Surprenant et al., 1992).	Aspartic Acid	59-68	adrenergic receptor, alpha 2a	Mus musculus	115-125
9398335-3	1997	Sequence comparisons of ACC oxidases with isopenicillin N synthase (IPNS) and members of the 2-oxoglutarate Fe(II) dependent dioxygenases show an aspartate and two of six ACC oxidase conserved histidine residues are completely conserved throughout this subfamily of Fe(II) dependent oxygenases/oxidases.	Aspartic Acid	146-155	1-aminocyclopropane-1-carboxylate oxidase	Solanum lycopersicum	24-35
9405472-4	1997	The sequence of several proEMAP II proteins suggests that the p43 component of the complex is the precursor of the active mature cytokine after cleavage at a conserved Asp residue.	Aspartic Acid	168-171	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	62-65
9398305-2	1997	We have investigated the capacity of glutamic and aspartic acids at position 64 in human CA III and murine CA V to act as proton shuttles in this pathway.	Aspartic Acid	50-64	carbonic anhydrase 3	Homo sapiens	89-95
9398305-7	1997	When the active site residue Phe 198 in human CA III was replaced with Leu, measurement of catalysis showed that Glu 64 retained but Asp 64 lost its capacity to act as a proton shuttle.	Aspartic Acid	133-136	carbonic anhydrase 3	Homo sapiens	46-52
9398305-8	1997	These observations were supported in studies of catalysis by murine CA V which contains Leu 198; here again, Glu 64 acted as a proton shuttle, but Asp 64 did not.	Aspartic Acid	147-150	carbonic anhydrase 5a, mitochondrial	Mus musculus	68-72
9617765-3	1998	Analysis of the amino-terminal residues of purified coat protein (CP) suggests that the CP gene is located between nts 1361 and 2959 (from the 3" terminus) in the RNA2, and that Asp/Ser is the proteolytic cleavage site of CP in the RNA2 encoded polyprotein.	Aspartic Acid	178-181	golgi phosphoprotein 3	Homo sapiens	52-64
9617765-3	1998	Analysis of the amino-terminal residues of purified coat protein (CP) suggests that the CP gene is located between nts 1361 and 2959 (from the 3" terminus) in the RNA2, and that Asp/Ser is the proteolytic cleavage site of CP in the RNA2 encoded polyprotein.	Aspartic Acid	178-181	golgi phosphoprotein 3	Homo sapiens	66-68
9407108-6	1997	The protein domains of the keratin fragments were determined using epitope-defined antibodies, and microsequencing indicated that K18 cleavage occurs at a conserved caspase-specific aspartic acid.	Aspartic Acid	182-195	keratin 18	Homo sapiens	130-133
10322749-3	1998	RESULTS: Indicated that exposure to CS2 could cause decrease in 3-methoxy-4-hydroxy mandelic acid (VMA), increase in 3,4-dioxybenzoic acid, a metabolite of dopamine, and high vanillic acid in rat straitum, decrease in excitatory amino acids and their metabolites (glutamine, aspartic acid and asparagine), with a certain relationship between contents of VMA, aspartic acid and asparagine and changes in neurobehavior.	Aspartic Acid	275-288	calsyntenin 2	Rattus norvegicus	36-39
10322749-3	1998	RESULTS: Indicated that exposure to CS2 could cause decrease in 3-methoxy-4-hydroxy mandelic acid (VMA), increase in 3,4-dioxybenzoic acid, a metabolite of dopamine, and high vanillic acid in rat straitum, decrease in excitatory amino acids and their metabolites (glutamine, aspartic acid and asparagine), with a certain relationship between contents of VMA, aspartic acid and asparagine and changes in neurobehavior.	Aspartic Acid	359-372	calsyntenin 2	Rattus norvegicus	36-39
9425317-3	1997	The peptides, Arg-Gly-Asp (RGD) and Glu-Ile-Leu-Asp-Val (EILDV) which were reported as active fragments of Fibronectin (a cell adhesion protein), were conjugated with aaPEG (molecular weight, 10,000).	Aspartic Acid	22-25	fibronectin 1	Homo sapiens	107-118
9435899-5	1997	Compound 6 (Hpa(SO3H)-Nle-Gly-Trp-Nle-MeAsp-Phe-NH2), derived from moving the N-methyl group from Phe to Asp, decreased CCK-B affinity substantially without affecting CCK-A affinity, giving a compound with 6600-fold selectivity for CCK-A receptors.	Aspartic Acid	40-43	cholecystokinin	Rattus norvegicus	120-123
9435899-5	1997	Compound 6 (Hpa(SO3H)-Nle-Gly-Trp-Nle-MeAsp-Phe-NH2), derived from moving the N-methyl group from Phe to Asp, decreased CCK-B affinity substantially without affecting CCK-A affinity, giving a compound with 6600-fold selectivity for CCK-A receptors.	Aspartic Acid	40-43	cholecystokinin	Rattus norvegicus	167-170
9398335-5	1997	To investigate the role of the conserved aspartate and histidine residues in ACC oxidase (tomato fruit), they were substituted via site-directed mutagenesis.	Aspartic Acid	41-50	1-aminocyclopropane-1-carboxylate oxidase	Solanum lycopersicum	77-88
9435899-5	1997	Compound 6 (Hpa(SO3H)-Nle-Gly-Trp-Nle-MeAsp-Phe-NH2), derived from moving the N-methyl group from Phe to Asp, decreased CCK-B affinity substantially without affecting CCK-A affinity, giving a compound with 6600-fold selectivity for CCK-A receptors.	Aspartic Acid	40-43	cholecystokinin	Rattus norvegicus	167-170
9396761-4	1997	Mutation of the single Arg-Gly-Asp (RGD) motif in human L1-Ig6 effectively abrogated binding by the aforementioned integrins.	Aspartic Acid	31-34	L1 cell adhesion molecule	Homo sapiens	56-62
9399746-5	1997	In two ulcerative colitis patients, a mutation was found in the Ki-ras gene (Gly --&gt; Asp 12 and Gly --&gt; Val 12), and in one patient, a mutation in exon 5 of the p53 gene.	Aspartic Acid	88-91	KRAS proto-oncogene, GTPase	Homo sapiens	64-70
9398246-2	1997	In this study, we have mutated two putative G protein-coupling regions of CXCR2 and characterized the effects of these mutations on ligand-activated signal transductions: aspartic acid 89 in the second transmembrane domain and the HRAMR sequence (BBXXB motif, found in the third intracellular loop where B indicates a basic amino acid and X represents any amino acid).	Aspartic Acid	171-184	C-X-C motif chemokine receptor 2	Homo sapiens	74-79
9398207-1	1997	Human serum transferrin N-lobe (hTF/2N) has four iron-binding ligands, including one histidine, one aspartate, and two tyrosines.	Aspartic Acid	100-109	transferrin	Homo sapiens	12-23
9395474-4	1997	Mutation of the histidine (H43Q) or aspartic acid (D45A) residues of this motif reduced the ability of Csp to stimulate the ATPase activity of mammalian Hsc70.	Aspartic Acid	36-49	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	103-106
9395474-4	1997	Mutation of the histidine (H43Q) or aspartic acid (D45A) residues of this motif reduced the ability of Csp to stimulate the ATPase activity of mammalian Hsc70.	Aspartic Acid	36-49	heat shock protein family A (Hsp70) member 8	Homo sapiens	153-158
9395478-2	1997	Cells adhere to the extracellular matrix proteins fibronectin and tenascin in part by the interaction of certain integrins with the Arg-Gly-Asp (RGD) sequence, displayed on specific FNIII repeats.	Aspartic Acid	140-143	fibronectin 1	Homo sapiens	50-61
9395478-2	1997	Cells adhere to the extracellular matrix proteins fibronectin and tenascin in part by the interaction of certain integrins with the Arg-Gly-Asp (RGD) sequence, displayed on specific FNIII repeats.	Aspartic Acid	140-143	tenascin C	Homo sapiens	66-74
9388263-1	1997	It has been shown that the relative reaction preference of the C4 thiol ester toward oxygen and nitrogen nucleophiles upon activation by proteinase depends on whether residue 1106 is aspartate or histidine (Dodds, A. W., Ren, X.-D., Willis, A. C., and Law, S. K. A.	Aspartic Acid	183-192	renin	Homo sapiens	221-224
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Aspartic Acid	266-275	alpha-2-macroglobulin	Homo sapiens	113-120
9371728-8	1997	A high-aspartate diet also increased the amount of NBAT mRNA in mouse ileum.	Aspartic Acid	7-16	solute carrier family 3, member 1	Mus musculus	51-55
9371728-10	1997	Hybrid depletion of NBAT mRNA from ileal polyadenylated RNA revealed that the increase in cystine transport activity induced by the high-aspartate diet, as measured in Xenopus oocytes, was attributable to NBAT.	Aspartic Acid	137-146	solute carrier family 3, member 1	Mus musculus	20-24
16501446-3	1997	Recently, the changes of plasma aminoacidograms induced by the administration of high-dose BCAA in sepsis have been better detailed: 1) a tendency to normalization of high levels of proline and of other amino acids transported intracellularly by transport system ""A""; 2) less relevant reduction of the levels of other amino acids; 3) increase of the levels of taurine, glutamate and aspartate; more complex interactions with specific amino acids.	Aspartic Acid	385-394	AT-rich interaction domain 4B	Homo sapiens	91-95
9476130-3	1997	One point mutation in the codon for Gly at position 15 (GGT) of the B chain was found resulting in an amino acid substitution to Asp (GAT).	Aspartic Acid	129-132	glycine-N-acyltransferase	Homo sapiens	134-137
9361194-4	1997	Several Asp residues are located in amino acids 341-421 of RB protein, and cleavage of any one of these sites by a caspase would generate a p48, which contains the amino terminus, and a p68 fragment, which contains the A/B pocket and the carboxyl terminus.	Aspartic Acid	8-11	interferon regulatory factor 9	Homo sapiens	140-143
9361194-4	1997	Several Asp residues are located in amino acids 341-421 of RB protein, and cleavage of any one of these sites by a caspase would generate a p48, which contains the amino terminus, and a p68 fragment, which contains the A/B pocket and the carboxyl terminus.	Aspartic Acid	8-11	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	186-189
9400368-9	1997	The presence of Lys 40 in S1" of human chymase explains its preference for Asp/Glu at P1".	Aspartic Acid	75-78	chymase 1	Homo sapiens	39-46
9368024-0	1997	Severely impaired polymerization of recombinant fibrinogen gamma-364 Asp --&gt; His, the substitution discovered in a heterozygous individual.	Aspartic Acid	69-72	fibrinogen beta chain	Homo sapiens	48-58
9367996-2	1997	We show that the cell-death protease CPP32 (caspase-3) in vitro specifically cleaved chicken and human IkappaB-alpha at a conserved Asp-Ser sequence.	Aspartic Acid	132-135	caspase 3	Homo sapiens	37-42
9427555-5	1997	Rat caspase-2 also has several Asp residues in the amino and carboxyl cleavage regions similar to other caspase family proteins.	Aspartic Acid	31-34	caspase 2	Rattus norvegicus	4-13
9367996-2	1997	We show that the cell-death protease CPP32 (caspase-3) in vitro specifically cleaved chicken and human IkappaB-alpha at a conserved Asp-Ser sequence.	Aspartic Acid	132-135	caspase 3	Gallus gallus	44-53
9367996-2	1997	We show that the cell-death protease CPP32 (caspase-3) in vitro specifically cleaved chicken and human IkappaB-alpha at a conserved Asp-Ser sequence.	Aspartic Acid	132-135	NFKB inhibitor alpha	Homo sapiens	103-116
9367996-5	1997	CPP32 also cleaved mammalian IkappaB-beta in vitro at the analogous Asp-Ser sequence.	Aspartic Acid	68-71	caspase 3	Homo sapiens	0-5
9453229-4	1997	Furthermore, labelling patterns in C-2 and C-3 in intracellular aspartate showed entry of [1,2-13C]acetyl-CoA into the TCA cycle; evidence for pyruvate-recycling.	Aspartic Acid	64-73	complement C2	Homo sapiens	35-38
9453229-4	1997	Furthermore, labelling patterns in C-2 and C-3 in intracellular aspartate showed entry of [1,2-13C]acetyl-CoA into the TCA cycle; evidence for pyruvate-recycling.	Aspartic Acid	64-73	complement C3	Homo sapiens	43-46
9342325-9	1997	A prominent exception represents thrombin"s Arg-77A side chain, which extends into a hydrophobic triabin pocket forming partially buried salt bridges with Glu-128 and Asp-135 of the inhibitor.	Aspartic Acid	167-170	coagulation factor II, thrombin	Bos taurus	33-41
9369469-0	1997	Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --&gt; asparagine mutant.	Aspartic Acid	56-65	thioredoxin	Homo sapiens	6-17
9369469-0	1997	Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --&gt; asparagine mutant.	Aspartic Acid	99-108	thioredoxin	Homo sapiens	6-17
9356458-3	1997	Most HH patients are homozygous for a Cys-282--&gt;Tyr (C282Y) mutation in HFE gene, which has been shown to disrupt interaction with beta2-microglobulin; a second mutation, His-63--&gt;Asp (H63D), is enriched in HH patients who are heterozygous for C282Y mutation.	Aspartic Acid	186-189	homeostatic iron regulator	Homo sapiens	75-78
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Aspartic Acid	203-206	membrane metalloendopeptidase	Homo sapiens	78-88
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Aspartic Acid	252-255	membrane metalloendopeptidase	Homo sapiens	78-88
9351900-0	1997	Gender, age and dose effects of neonatally administered aspartate on the sexually dimorphic plasma growth hormone profiles regulating expression of the rat sex-dependent hepatic CYP isoforms.	Aspartic Acid	56-65	gonadotropin releasing hormone receptor	Rattus norvegicus	99-113
9351900-0	1997	Gender, age and dose effects of neonatally administered aspartate on the sexually dimorphic plasma growth hormone profiles regulating expression of the rat sex-dependent hepatic CYP isoforms.	Aspartic Acid	56-65	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	178-181
9351900-6	1997	In a similar sense, females treated with 2 mg of MSA maintained their sexually dimorphic pattern of plasma growth hormone, i.e., frequent pulses of hormone followed by short-lived troughs.	Aspartic Acid	49-52	gonadotropin releasing hormone receptor	Rattus norvegicus	107-121
9359580-2	1997	The gene product is a 271 amino acid protein that contains the conserved serine, histidine and aspartic acid residues found in serine proteases, and has the highest identity to a serine protease of unknown function from Drosophila melanogaster.	Aspartic Acid	95-108	Jonah 99Ci	Drosophila melanogaster	127-142
9343381-6	1997	A change in residue 533 of Cbp1 from aspartate to tyrosine suppresses the effects of a single-base change in the CCG element.	Aspartic Acid	37-46	Cbp1p	Saccharomyces cerevisiae S288C	27-31
9341147-0	1997	Aspartate 171 is the major primate-specific determinant of human growth hormone.	Aspartic Acid	0-9	growth hormone 1	Homo sapiens	65-79
9342335-5	1997	As a result, the charged residues Glu-31 and Asp-33, which interact with Raf in the homologous RafRBD-Raps complex, remain exposed during the transition.	Aspartic Acid	45-48	zinc fingers and homeoboxes 2	Homo sapiens	73-76
9325266-2	1997	The second domain of cytosolic glutathione S-transferases (GSTs) contains a strictly conserved N-capping box motif (Ser/Thr-Xaa-Xaa-Asp) at the beginning of alpha6-helix in the hydrophobic core of the molecule.	Aspartic Acid	132-135	glutathione S-transferase pi 1	Homo sapiens	59-63
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Aspartic Acid	87-90	S100 calcium binding protein B	Homo sapiens	68-71
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Aspartic Acid	87-90	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Aspartic Acid	87-90	S100 calcium binding protein B	Homo sapiens	239-242
21528263-6	1997	An A to G nucleotide substitution giving rise to an amino acid substitution (Asn--&gt;Asp) in codon 21 at the first potential N-glycosylation site of the P-glycoprotein was seen in primary tumors from four patients and in an axillar lymph node metastases from one of these patients.	Aspartic Acid	86-89	ATP binding cassette subfamily B member 1	Homo sapiens	154-168
9351595-7	1997	In addition, a high proportion of TDI asthmatics express the HLA-DQB1*0503-associated aspartic acid at residue 57, suggesting that HLA-DQ may have a key role in conferring susceptibility.	Aspartic Acid	86-99	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	61-69
9351595-7	1997	In addition, a high proportion of TDI asthmatics express the HLA-DQB1*0503-associated aspartic acid at residue 57, suggesting that HLA-DQ may have a key role in conferring susceptibility.	Aspartic Acid	86-99	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	61-64
9342184-1	1997	Osteopontin (OPN) is a secreted phosphoprotein that binds to cells via an Arg-Gly-Asp sequence and to mineralized surfaces.	Aspartic Acid	82-85	secreted phosphoprotein 1	Mus musculus	0-11
9342184-1	1997	Osteopontin (OPN) is a secreted phosphoprotein that binds to cells via an Arg-Gly-Asp sequence and to mineralized surfaces.	Aspartic Acid	82-85	secreted phosphoprotein 1	Mus musculus	13-16
9322922-6	1997	Substitutions of Ser354 with negatively charged amino acids, such as Asp or Glu, dramatically decreased Nur77 DNA-binding and trans-activation activities, whereas mutation to the neutral Ala had no effect.	Aspartic Acid	69-72	nuclear receptor subfamily 4 group A member 1	Homo sapiens	104-109
21528268-6	1997	Since aspartic acid at this position is conserved between all four human and murine INK4 proteins, this missense mutation may have functional significance.	Aspartic Acid	6-19	cyclin dependent kinase inhibitor 2A	Homo sapiens	84-88
9407392-7	1997	These include near-field circulations in the brain and the eye, and a far-field systemic circulation involving the liver and kidney, the purpose of which in each case is apparently to regenerate aspartate (Asp) in order for it to be recycled into NAA as part of the still unknown function of the NAA cycle.	Aspartic Acid	195-204	assembly factor for spindle microtubules	Homo sapiens	206-209
9419055-1	1997	To investigate the spinal cellular structures and molecular mechanisms involved in acetylcholinesterase (AChE) release evoked by both glycine (GLY) and glutamate (GLU)--responses that might play a role in chronic neurotoxicity--we analysed AChE histochemistry and histology upon systemic administration of aspartate (ASP), and conducted in vitro experiments in synaptosomes and slices prepared from mouse spinal ventral horns.	Aspartic Acid	306-315	acetylcholinesterase	Mus musculus	105-109
9419055-1	1997	To investigate the spinal cellular structures and molecular mechanisms involved in acetylcholinesterase (AChE) release evoked by both glycine (GLY) and glutamate (GLU)--responses that might play a role in chronic neurotoxicity--we analysed AChE histochemistry and histology upon systemic administration of aspartate (ASP), and conducted in vitro experiments in synaptosomes and slices prepared from mouse spinal ventral horns.	Aspartic Acid	317-320	acetylcholinesterase	Mus musculus	105-109
9329083-8	1997	A major difference is the participation of Arg 312 and Asp 313 in lining the inhibitor-binding site in aldehyde reductase but not in aldose reductase.	Aspartic Acid	55-58	aldo-keto reductase family 1 member A1	Homo sapiens	103-121
9298990-7	1997	Consistent with this model, mutation of arginine 118 (R118) in MAG to either alanine or aspartate abolishes its sialic acid-dependent binding.	Aspartic Acid	88-97	myelin associated glycoprotein	Homo sapiens	63-66
9380693-6	1997	A Smad3 protein in which the three C-terminal serines have been replaced by aspartic acids is also a dominant inhibitor of TGF-beta signaling, but can activate plasminogen activator inhibitor 1 (PAI-1) transcription in a ligand-independent fashion when its nuclear localization is forced by transient overexpression.	Aspartic Acid	76-90	SMAD family member 3	Homo sapiens	2-7
9380693-6	1997	A Smad3 protein in which the three C-terminal serines have been replaced by aspartic acids is also a dominant inhibitor of TGF-beta signaling, but can activate plasminogen activator inhibitor 1 (PAI-1) transcription in a ligand-independent fashion when its nuclear localization is forced by transient overexpression.	Aspartic Acid	76-90	decapentaplegic	Drosophila melanogaster	123-131
9287334-1	1997	Vitamin K-dependent protein S, a cofactor of the anticoagulant enzyme-activated protein C, has four epidermal growth factor (EGF)-like modules, all of which have one partially hydroxylated Asp (EGF 1; beta-hydroxyaspartic acid) or Asn (EGF 2, 3, and 4; beta-hydroxyasparagine) residue.	Aspartic Acid	189-192	protein S	Homo sapiens	0-29
9374203-7	1997	In line with its enhancement of paired-pulse facilitation, 30 microM proline reduced both the K+-evoked release of glutamate and aspartate from CA1 slices and the release of glutamate and aspartate from CA1 synaptosomes evoked by 4-aminopyridine.	Aspartic Acid	129-138	carbonic anhydrase 1	Homo sapiens	144-147
9374203-7	1997	In line with its enhancement of paired-pulse facilitation, 30 microM proline reduced both the K+-evoked release of glutamate and aspartate from CA1 slices and the release of glutamate and aspartate from CA1 synaptosomes evoked by 4-aminopyridine.	Aspartic Acid	188-197	carbonic anhydrase 1	Homo sapiens	203-206
9311142-2	1997	Our results suggest that in C. freundii DNA gyrase may be a primary target of quinolones, that an amino acid change at Thr-83 or Asp-87 in GyrA is sufficient to decrease susceptibility to fluoroquinolones, and that accumulation of changes in GyrA with the simultaneous presence of an alteration at Ser-80 or Glu-84 in ParC may be associated with the development of high-level fluoroquinolone resistance in C. freundii clinical isolates.	Aspartic Acid	129-132	cullin 9	Homo sapiens	318-322
9347948-2	1997	In the presence of extracellular Ca2+, CCK-8S increased the basal release of glutamate, but not of aspartate and GABA.	Aspartic Acid	99-108	cholecystokinin	Rattus norvegicus	39-42
9347948-5	1997	The CCKB receptor antagonist L365,260 (1 microM) blocked the CCK-8S-induced release of glutamate by 70%, and of aspartate by 100%.	Aspartic Acid	112-121	cholecystokinin	Rattus norvegicus	4-7
9357955-0	1997	Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation.	Aspartic Acid	0-9	transketolase	Homo sapiens	23-36
9316505-6	1997	A 120-kDa chymotryptic fragment of fibronectin containing the Arg-Gly-Asp peptide sequence was able to reproduce the effects of the whole fibronectin molecule.	Aspartic Acid	70-73	fibronectin 1	Homo sapiens	35-46
9316505-6	1997	A 120-kDa chymotryptic fragment of fibronectin containing the Arg-Gly-Asp peptide sequence was able to reproduce the effects of the whole fibronectin molecule.	Aspartic Acid	70-73	fibronectin 1	Homo sapiens	138-149
9291097-9	1997	In addition, cm1, cm2, cm3, chs and cht ascorbate peroxidases contain Asp-43, Asn-57 and Ser-59, indicative of a distal monovalent cation site.	Aspartic Acid	70-73	chorismate mutase 1	Arabidopsis thaliana	13-16
9291097-9	1997	In addition, cm1, cm2, cm3, chs and cht ascorbate peroxidases contain Asp-43, Asn-57 and Ser-59, indicative of a distal monovalent cation site.	Aspartic Acid	70-73	chorismate mutase 3	Arabidopsis thaliana	23-26
9291099-3	1997	The fourth SCR of both proteins (SCR 4) includes the sequence Arg-Gly-Asp (RGD), a motif that is responsible for the major adhesive activity of matrix proteins like fibronectin.	Aspartic Acid	70-73	fibronectin 1	Homo sapiens	165-176
9324018-5	1997	RESULTS: Four (6%) of 72 patients with RA, 2 (13%) of 16 with OA, and 1 (8%) of 12 with other arthropathies harbored mutant H-ras proto-oncogenes, and were heterozygous at codon 13 for the GGT--&gt;GAT (Gly--&gt;Asp) change.	Aspartic Acid	212-215	HRas proto-oncogene, GTPase	Homo sapiens	124-129
9265630-4	1997	Homology searches using the 10 amino acid sequence SxHxxGxAxD, in which histidine and aspartate residues are putative zinc ligands, identified the metal coordinating ligands in the N-terminal domain of the murine Sonic hedgehog protein, which also exhibits an architecture for metal coordination identical to that observed in thermolysin from Bacillus thermoproteolyticus.	Aspartic Acid	86-95	sonic hedgehog	Mus musculus	213-235
9268623-4	1997	Lungfish insulin also contains amino acid substitutions such as Gly --&gt; Ala at position B-21, Glu --&gt; Asp at position B-22, and a Lys --&gt; Ser residue at position B-30, previously found in insulins from amphibia.	Aspartic Acid	108-111	insulin	Homo sapiens	9-16
9308722-5	1997	Only 2 of 22 (9%) patients harbored a p53 mutation (which, interestingly, were identical and consisted of a codon 259 Asp --&gt; His exchange), despite diffuse overexpression of high levels of nuclear p53 protein in most cases.	Aspartic Acid	118-121	tumor protein p53	Homo sapiens	38-41
9268342-5	1997	In the present study, we show that LysoPLA I represents a new member of the serine hydrolase family with Ser-119, Asp-174, and His-208 composing the catalytic triad.	Aspartic Acid	114-117	lysophospholipase 1	Mus musculus	35-44
9268311-4	1997	The primary effect of simultaneous replacement of the adjacent Asp-279 and Ile-280 residues in IDH1 with alanines is a dramatic loss of activation by AMP.	Aspartic Acid	63-66	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	95-99
9268342-6	1997	The Asp-174 and His-208 are conserved among several esterases and are demonstrated herein to be essential for LysoPLA I activity as the mutation of either residue to Ala abolished LysoPLA I activity, whereas the global conformation of the mutants remained unchanged.	Aspartic Acid	4-7	lysophospholipase 1	Mus musculus	110-119
9268342-7	1997	Furthermore, the predicted secondary structure of LysoPLA I resembles that of the alpha/beta-hydrolase fold, with Ser-119, Asp-174, and His-208 occupying the conserved topological location of the catalytic triad in the alpha/beta-hydrolases.	Aspartic Acid	123-126	lysophospholipase 1	Mus musculus	50-59
9268342-6	1997	The Asp-174 and His-208 are conserved among several esterases and are demonstrated herein to be essential for LysoPLA I activity as the mutation of either residue to Ala abolished LysoPLA I activity, whereas the global conformation of the mutants remained unchanged.	Aspartic Acid	4-7	lysophospholipase 1	Mus musculus	180-189
9268311-5	1997	In contrast, alanine replacement of the homologous Asp-286 and Ile-287 residues in IDH2 does not alter the allosteric response to AMP, but produces a 160-fold reduction in Vmax due to a 70-fold increase in the S0.5 value for NAD+.	Aspartic Acid	51-54	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	83-87
9268311-6	1997	These results suggest that the targeted aspartate/isoleucine residues may contribute to regulator binding in IDH1 and to cofactor binding in IDH2, i.e. that these homologous residues are located in regions that have evolved for binding the adenine nucleotide components of different ligands.	Aspartic Acid	40-49	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	109-113
9268311-6	1997	These results suggest that the targeted aspartate/isoleucine residues may contribute to regulator binding in IDH1 and to cofactor binding in IDH2, i.e. that these homologous residues are located in regions that have evolved for binding the adenine nucleotide components of different ligands.	Aspartic Acid	40-49	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	141-145
9268311-7	1997	In other mutant enzymes, an alanine replacement of Asp-191 in IDH1 eliminates measurable catalytic activity, and a similar substitution of the homologous Asp-197 in IDH2 produces pleiotropic catalytic effects.	Aspartic Acid	51-54	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	62-66
9268311-8	1997	A model is presented for the primary function of IDH2 in catalysis and of IDH1 in regulation, with crucial roles for these single aspartate residues in the communication and functional interdependence of the two subunits.	Aspartic Acid	130-139	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	49-53
9268311-8	1997	A model is presented for the primary function of IDH2 in catalysis and of IDH1 in regulation, with crucial roles for these single aspartate residues in the communication and functional interdependence of the two subunits.	Aspartic Acid	130-139	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	74-78
9285556-3	1997	In Raf-1 the phosphorylation or mutation to aspartic acid of two key tyrosine residues upstream of the ATP binding site has been demonstrated to significantly potentiate catalytic activity.	Aspartic Acid	44-57	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	3-8
9268342-7	1997	Furthermore, the predicted secondary structure of LysoPLA I resembles that of the alpha/beta-hydrolase fold, with Ser-119, Asp-174, and His-208 occupying the conserved topological location of the catalytic triad in the alpha/beta-hydrolases.	Aspartic Acid	123-126	abhydrolase domain containing 15	Mus musculus	82-102
9285556-4	1997	In A-Raf the analogous amino acids are also tyrosine whereas in B-Raf they are aspartic acid.	Aspartic Acid	79-92	A-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	3-8
9300641-3	1997	As many extracellular matrix (ECM) molecules contain the conserved amino acid sequence arg-gly-asp-ser (RGDS) at the integrin recognition site, integrin-ECM binding can be disrupted using RGDS peptides.	Aspartic Acid	95-98	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	104-108
9285556-13	1997	In addition they demonstrate that the higher intrinsic activity of B-Raf cannot be explained simply by the presence of aspartic acids at the analogous positions.	Aspartic Acid	119-133	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	67-72
9256424-3	1997	Here we report that nm23-H1 can transfer a phosphate from its catalytic histidine to aspartate or glutamate residues on 43-kDa membrane proteins.	Aspartic Acid	85-94	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	20-27
9256424-8	1997	Thus, the transfer of phosphate from nm23-H1 to aspartates or glutamates on other proteins appears to correlate better with the suppression of motility than does the transfer to histidines.	Aspartic Acid	48-58	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	37-44
9276012-4	1997	In particular, the 8-amino function on the tropane skeleton of cocaine and cocaine analogs has been assumed to provide an ionic bond to the aspartic acid residue on the dopamine transporter (DAT).	Aspartic Acid	140-153	solute carrier family 6 member 3	Homo sapiens	169-189
9276012-4	1997	In particular, the 8-amino function on the tropane skeleton of cocaine and cocaine analogs has been assumed to provide an ionic bond to the aspartic acid residue on the dopamine transporter (DAT).	Aspartic Acid	140-153	solute carrier family 6 member 3	Homo sapiens	191-194
9300641-3	1997	As many extracellular matrix (ECM) molecules contain the conserved amino acid sequence arg-gly-asp-ser (RGDS) at the integrin recognition site, integrin-ECM binding can be disrupted using RGDS peptides.	Aspartic Acid	95-98	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	188-192
9241275-8	1997	In a three-generation French family with monilethrix of a milder and variable phenotype, we detected another heterozygous point mutation in the same glutamic acid codon of hHb6, which resulted in a conservative aspartic acid substitution (Glu 410 Asp).	Aspartic Acid	211-224	keratin 86	Homo sapiens	172-176
9276438-6	1997	Unlike any other known phosphatase, PP2C gamma has a highly acidic domain: 75% of the 54 residues are glutamate or aspartate.	Aspartic Acid	115-124	protein phosphatase, Mg2+/Mn2+ dependent 1G	Homo sapiens	36-46
9237811-7	1997	Substitutions Asp --&gt; Asn, Asp --&gt; Lys, Asp --&gt; Leu, show a correlation between diminished affinity for IL-2 receptor and reduced bioactivity measured on TS1beta cells.	Aspartic Acid	14-17	interleukin 2 receptor subunit beta	Homo sapiens	113-126
9257709-2	1997	Recombinant human glycosylasparaginase is capable of catalyzing the hydrolysis of the amino acid L-asparagine to L-aspartic acid and ammonia.	Aspartic Acid	113-128	aspartylglucosaminidase	Homo sapiens	18-38
9218460-5	1997	The carboxyl-terminal tetrapeptide His-Asp-Glu-Phe was shown to be responsible for retention of calumenin in ER by the retention assay, immunostaining with a confocal laser microscope, and the deglycosylation assay.	Aspartic Acid	39-42	calumenin	Mus musculus	96-105
9211865-2	1997	The high affinity interaction of integrin alpha5beta1 with the central cell binding domain (CCBD) of fibronectin requires both the Arg-Gly-Asp (RGD) sequence (in the 10th type III repeat) and a second site (in the adjacent 9th type III repeat) which synergizes with RGD.	Aspartic Acid	139-142	fibronectin 1	Homo sapiens	101-112
9224629-1	1997	Asp-70 is the defining amino acid in the peripheral anionic site of human butyrylcholinesterase (BuChE), whereas acetylcholinesterase has several additional amino acids, the most important one being Trp-277 (Trp-279 in Torpedo AChE).	Aspartic Acid	0-3	acetylcholinesterase (Cartwright blood group)	Homo sapiens	227-231
9230079-6	1997	p41-Arc is a new member of the Sop2 family of WD (tryptophan and aspartate) repeat-containing proteins and may be posttranslationally modified, suggesting that it may be involved in regulating the activity and/or localization of the complex.	Aspartic Acid	65-74	mitogen-activated protein kinase 1	Homo sapiens	0-3
9218614-5	1997	Phosphopeptide competition assays demonstrate that the association of CD7 with PI 3-K is dependent on tyrosine phosphorylation of the SH2 binding motif Tyr-Glu-Asp-Met (YEDM) in the CD7 cytoplasmic domain.	Aspartic Acid	160-163	CD7 molecule	Homo sapiens	70-73
9218614-5	1997	Phosphopeptide competition assays demonstrate that the association of CD7 with PI 3-K is dependent on tyrosine phosphorylation of the SH2 binding motif Tyr-Glu-Asp-Met (YEDM) in the CD7 cytoplasmic domain.	Aspartic Acid	160-163	CD7 molecule	Homo sapiens	182-185
9218620-5	1997	However, the mutant with Asp at this position is unable to bind C1r and beta factor XIIa, and also has a decreased rate of reaction with C1s and kallikrein.	Aspartic Acid	25-28	complement C1r	Homo sapiens	64-67
9218620-5	1997	However, the mutant with Asp at this position is unable to bind C1r and beta factor XIIa, and also has a decreased rate of reaction with C1s and kallikrein.	Aspartic Acid	25-28	complement C1s	Homo sapiens	137-140
9237811-7	1997	Substitutions Asp --&gt; Asn, Asp --&gt; Lys, Asp --&gt; Leu, show a correlation between diminished affinity for IL-2 receptor and reduced bioactivity measured on TS1beta cells.	Aspartic Acid	30-33	interleukin 2 receptor subunit beta	Homo sapiens	113-126
9237811-7	1997	Substitutions Asp --&gt; Asn, Asp --&gt; Lys, Asp --&gt; Leu, show a correlation between diminished affinity for IL-2 receptor and reduced bioactivity measured on TS1beta cells.	Aspartic Acid	30-33	interleukin 2 receptor subunit beta	Homo sapiens	113-126
9237811-8	1997	Mutein Asp Arg lose affinity for IL-2R and bioactivity simultaneously.	Aspartic Acid	7-10	interleukin 2 receptor subunit alpha	Homo sapiens	33-38
9260929-2	1997	Previously, we have shown that the mature protein, formerly known as BA46, has three domains: an epidermal growth factor (EGF)-like domain containing an Arg-Gly-Asp (RGD) cell adhesion sequence and C1 and C2 domains similar to those found in coagulation factors V and VIII.	Aspartic Acid	161-164	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	69-73
9260929-0	1997	Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion.	Aspartic Acid	128-131	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-11
9199447-4	1997	Purified human fibrinogen and peptides containing the sequence Arg-Gly-Asp (RGD) were also found to promote bacterial invasion of cultured cells.	Aspartic Acid	71-74	fibrinogen beta chain	Homo sapiens	15-25
9260929-0	1997	Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion.	Aspartic Acid	128-131	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	22-26
9251683-2	1997	Osteopontin (OPN), a ligand for the alpha v beta 3 integrin, is a secreted glycoprotein with a glycine-arginine-glycine-aspartate-serine cell-binding domain.	Aspartic Acid	120-129	secreted phosphoprotein 1	Homo sapiens	0-11
9285539-10	1997	These findings are consistent with the notion that inhibition of ChE and elevation of ACh initiate the seizure process, resulting in secondary changes in DA turnover and release of NE, and later changes in excitatory (aspartate, glutamate) and inhibitory (GABA) amino acid transmitters.	Aspartic Acid	218-227	butyrylcholinesterase	Rattus norvegicus	65-68
9254911-6	1997	Application of the charge state characterization schemes to the hydroxyethylene and statine transition state inhibitors of renin in the training set suggests a monoprotonation state of the two active-site aspartate residues, where the lone proton resides on the outer carboxylate oxygen of Asp226 is most likely.	Aspartic Acid	205-214	renin	Homo sapiens	123-128
9251683-2	1997	Osteopontin (OPN), a ligand for the alpha v beta 3 integrin, is a secreted glycoprotein with a glycine-arginine-glycine-aspartate-serine cell-binding domain.	Aspartic Acid	120-129	secreted phosphoprotein 1	Homo sapiens	13-16
9264120-4	1997	The ASP pathway is activated in order to trap the fatty acids released from chylomicrons by the action of LPL and there is now unequivocal in vivo evidence in human subjects that ASP is generated by adipocytes in the postprandial period.	Aspartic Acid	4-7	lipoprotein lipase	Homo sapiens	106-109
9264120-10	1997	Binding of chylomicrons to capillary endothelium followed by lipolysis by LPL results in the sudden liberation of fatty acids, and in the marked generation of ASP by adipocytes.	Aspartic Acid	159-162	lipoprotein lipase	Homo sapiens	74-77
9218558-4	1997	The mutation of a threonin into an aspartic acid residue from HlgA (T28D) and from HlgC (T30D) that would break this predicted N-terminal structure lowered dramatically the biological activities on purely lipidic vesicles, erythrocytes and polymorphonuclear cells.	Aspartic Acid	35-48	glutaminase 2	Homo sapiens	62-66
9205129-1	1997	The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats.	Aspartic Acid	158-167	PWP2 small subunit processome component	Homo sapiens	10-14
9205129-1	1997	The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats.	Aspartic Acid	158-167	snoRNA-binding rRNA-processing protein PWP2	Saccharomyces cerevisiae S288C	87-91
9177202-5	1997	We examined the reactivity of Di-OVA to PNGase HO and found that this enzyme site-specifically cleaved off the glycan chain at Asn-311 to convert Di-OVA into the mono-N-glycosylated form (CHO-Asn-292/Asp-311).	Aspartic Acid	200-203	N-glycanase 1	Homo sapiens	40-46
9177211-6	1997	Its putative ORF shares extensive (45%) homology with the genuine beta-subunit of CK2 and retains the conserved C-terminal and Glu/Asp-rich domains that are essential for CK2 holoenzyme regulation.	Aspartic Acid	131-134	Casein kinase II beta subunit	Drosophila melanogaster	82-85
9177211-6	1997	Its putative ORF shares extensive (45%) homology with the genuine beta-subunit of CK2 and retains the conserved C-terminal and Glu/Asp-rich domains that are essential for CK2 holoenzyme regulation.	Aspartic Acid	131-134	Casein kinase II beta subunit	Drosophila melanogaster	171-174
9207182-3	1997	However, six invariant amino acids such as a lysine in the ATP-binding site and an aspartic acid in the phosphotransfer site of a conserved catalytic domain were substituted with other amino acid residues in HEP.	Aspartic Acid	83-96	EPH receptor B6	Homo sapiens	208-211
9224695-3	1997	The change in protonation for binding of dCMP to wild-type enzyme is lower than that obtained for binding of this nucleotide to TS N229D, which suggests that the pK value of Asp-229 is increased upon dCMP binding to the mutant enzyme.	Aspartic Acid	174-177	cmp	Drosophila melanogaster	41-45
9224695-3	1997	The change in protonation for binding of dCMP to wild-type enzyme is lower than that obtained for binding of this nucleotide to TS N229D, which suggests that the pK value of Asp-229 is increased upon dCMP binding to the mutant enzyme.	Aspartic Acid	174-177	cmp	Drosophila melanogaster	200-204
9178956-4	1997	However, the accumulation of L-aspartate was "enhanced" by inhibitors of L-aspartate metabolism, such as the aspartate aminotransferase inhibitor, aminooxyacetate and L-methionine sulfoximine, an inhibitor of glutamine synthetase, whereas D-aspartate (a non-metabolizable analog of L-aspartate) uptake was not affected.	Aspartic Acid	29-40	glutamate-ammonia ligase	Homo sapiens	209-229
9166421-6	1997	We demonstrated that this phenotype could be reproduced simply by substituting the glutamic acid (E) at the mature NH2 terminus of the wild type TCR alpha chain with aspartic acid (D).	Aspartic Acid	166-179	T cell receptor alpha variable 6-3	Mus musculus	145-148
9174192-6	1997	This enzyme differed from TEM-1 (blaT-1B gene) by four amino acid substitutions: Met--&gt;Leu-69, Glu--&gt;Lys-104, Gly--&gt;Ser-238 and Asn--&gt;Asp-276.	Aspartic Acid	146-149	hypothetical protein	Escherichia coli	26-31
9328793-5	1997	Among the 250 retrospective samples, a single HPA probe for codon 57 aspartic acid consistently cross-reacted with the codon 57 valine sequence of DRB1*0807.	Aspartic Acid	69-82	major histocompatibility complex, class II, DR beta 1	Homo sapiens	147-151
9166423-8	1997	The rank order of the dissociation constant for the different GMR-alphaR280 mutations where Lys &gt; Gln &gt; Met &gt; Asp, suggesting the importance of the charge at this position.	Aspartic Acid	119-122	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	62-65
9209109-4	1997	It was found that L-aspartate inhibits norepinephrine-stimulated melatonin production as well as serotonin N-acetyltransferase activity reversibly and dose-dependently, the concentrations required for 50% inhibition being 150 and 175 microM, respectively.	Aspartic Acid	18-29	aralkylamine N-acetyltransferase	Rattus norvegicus	97-126
9199974-8	1997	This Asp, if present, may form a salt bridge with an Arg at position 79 of the alpha-chain and so alter the binding specificity of P9.	Aspartic Acid	5-8	Fc gamma receptor and transporter	Homo sapiens	79-90
9354393-3	1997	The Saccharomyces cerevisiae mutant with a disrupted CCC2 gene (yeast Menkes/Wilson disease gene homologue) was rescued by the cDNA for the C. elegans Cu2+-ATPase but not by the cDNA with an Asp-786 (an invariant phosphorylation site) to Asn mutation, suggesting that the C. elegans Cu2+-ATPase functions as a copper transporter in yeast.	Aspartic Acid	191-194	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	53-57
9178956-4	1997	However, the accumulation of L-aspartate was "enhanced" by inhibitors of L-aspartate metabolism, such as the aspartate aminotransferase inhibitor, aminooxyacetate and L-methionine sulfoximine, an inhibitor of glutamine synthetase, whereas D-aspartate (a non-metabolizable analog of L-aspartate) uptake was not affected.	Aspartic Acid	73-84	glutamate-ammonia ligase	Homo sapiens	209-229
9178956-4	1997	However, the accumulation of L-aspartate was "enhanced" by inhibitors of L-aspartate metabolism, such as the aspartate aminotransferase inhibitor, aminooxyacetate and L-methionine sulfoximine, an inhibitor of glutamine synthetase, whereas D-aspartate (a non-metabolizable analog of L-aspartate) uptake was not affected.	Aspartic Acid	73-84	glutamate-ammonia ligase	Homo sapiens	209-229
9162066-5	1997	The first C2-domain of synaptotagmin I (the C2A-domain) binds phospholipids as a function of Ca2+ and contains a Ca2+-binding site, the C2-motif, that binds at least two Ca2+ ions via five aspartate residues and is conserved in most C2-domains (Shao, X., Davletov, B., Sutton, B., Sudhof, T. C., Rizo, J. R. (1996) Science 273, 248-253).	Aspartic Acid	189-198	synaptotagmin 1	Homo sapiens	23-38
9153254-7	1997	Mutations of C56S and C82V alone or together and the deletion of Lys-2 and Asp-3 of LTC4S do not alter enzyme function.	Aspartic Acid	75-78	leukotriene C4 synthase	Homo sapiens	84-89
9162080-9	1997	Within the catalytic domain, the essential Asp, His, and Ser residues that conform the catalytic triad of this family of proteases are conserved in P69B.	Aspartic Acid	43-46	subtilisin-like protease	Solanum lycopersicum	148-152
9177774-3	1997	Comparison of the human DMP1-coding sequence with that of the rat, mouse, and cow indicated that the predicted protein contains a conserved hydrophobic signal peptide sequence and an Arg-Gly-Asp cell attachment sequence.	Aspartic Acid	191-194	dentin matrix acidic phosphoprotein 1	Homo sapiens	24-28
9171884-5	1997	The peptide Ac-Nle-c[Asp-His-Phe-Arg-D-Trp9-Ala-Lys]-NH2 demonstrated the greatest differentiation in binding affinity between the hMC1R and hMC4R (78-fold).	Aspartic Acid	21-24	melanocortin 1 receptor	Homo sapiens	131-146
9153399-6	1997	The glutamic acid residue at position 37 is critical for LFA-1 binding and is proposed to coordinate the Mg2+ ion in the I domain; this Glu 37 is surrounded by a relatively flat recognition surface and lies in a beta-strand, whereas the critical aspartic acid residue in VCAM-1 and fibronectin lie in protruding loops.	Aspartic Acid	246-259	integrin subunit alpha L	Homo sapiens	57-62
9153399-6	1997	The glutamic acid residue at position 37 is critical for LFA-1 binding and is proposed to coordinate the Mg2+ ion in the I domain; this Glu 37 is surrounded by a relatively flat recognition surface and lies in a beta-strand, whereas the critical aspartic acid residue in VCAM-1 and fibronectin lie in protruding loops.	Aspartic Acid	246-259	vascular cell adhesion molecule 1	Homo sapiens	271-277
9153399-6	1997	The glutamic acid residue at position 37 is critical for LFA-1 binding and is proposed to coordinate the Mg2+ ion in the I domain; this Glu 37 is surrounded by a relatively flat recognition surface and lies in a beta-strand, whereas the critical aspartic acid residue in VCAM-1 and fibronectin lie in protruding loops.	Aspartic Acid	246-259	fibronectin 1	Homo sapiens	282-293
9148890-8	1997	A mutant JEM1p carrying a mutation in the highly conserved His-Pro-Asp sequence in the J-domain could not complement either temperature-sensitive growth of the Deltajem1 Deltascj1 double mutant or defects in karyogamy of the Deltajem1 mutant.	Aspartic Acid	67-70	Jem1p	Saccharomyces cerevisiae S288C	9-14
9177271-1	1997	Gu/RNA helicase II (Gu/RH-II) is the first reported mammalian nucleolar RNA helicase that is a member of the D-E-A-D (Asp-Glu-Ala-Asp) box family of proteins.	Aspartic Acid	118-121	Rh blood group D antigen	Homo sapiens	23-28
9177271-1	1997	Gu/RNA helicase II (Gu/RH-II) is the first reported mammalian nucleolar RNA helicase that is a member of the D-E-A-D (Asp-Glu-Ala-Asp) box family of proteins.	Aspartic Acid	130-133	Rh blood group D antigen	Homo sapiens	23-28
9144172-0	1997	Constitutive signaling by the phototaxis receptor sensory rhodopsin II from disruption of its protonated Schiff base-Asp-73 interhelical salt bridge.	Aspartic Acid	117-120	rhodopsin	Homo sapiens	58-67
9144172-1	1997	Sensory rhodopsin II (SRII) is a repellent phototaxis receptor in the archaeon Halobacterium salinarum, similar to visual pigments in its seven-helix structure and linkage of retinal to the protein by a protonated Schiff base in helix G. Asp-73 in helix C is shown by spectroscopic analysis to be a counterion to the protonated Schiff base in the unphotolyzed SRII and to be the proton acceptor from the Schiff base during photoconversion to the receptor signaling state.	Aspartic Acid	238-241	rhodopsin	Homo sapiens	8-17
9144190-3	1997	Truncation of the terminal carboxyl-tail to eight amino acids or mutation of the highly conserved aspartate-arginine-tyrosine, or DRY, sequence in the second cytoplasmic loop of CCR5 effectively blocked chemokine-dependent activation of classic second messengers, intracellular calcium fluxes, and the cellular response of chemotaxis.	Aspartic Acid	98-107	C-C motif chemokine receptor 5	Homo sapiens	178-182
9115256-2	1997	A computer-generated model of the thyrotropin-releasing hormone receptor (TRH-R) indicated that conserved Asp-71 (TM-2) could interact with conserved asparagines 316 (TM-7) and 43 (TM-1).	Aspartic Acid	106-109	thyrotropin releasing hormone receptor	Homo sapiens	34-72
9115256-2	1997	A computer-generated model of the thyrotropin-releasing hormone receptor (TRH-R) indicated that conserved Asp-71 (TM-2) could interact with conserved asparagines 316 (TM-7) and 43 (TM-1).	Aspartic Acid	106-109	thyrotropin releasing hormone receptor	Homo sapiens	74-79
9177684-2	1997	A peptide substrate, Ac-Gly-Glu-Ala-Gly-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-Tyr-Thr-Trp-Thr-L ys (biotin) -OH (Sub-1), was hydrolyzed by a recombinant NS3 proteinase fused with maltose binding protein (MBP-NS3) into a product with a free amino moiety at the N-terminus.	Aspartic Acid	40-43	SUB1 regulator of transcription	Homo sapiens	111-116
9154935-0	1997	Effects of mutations of aspartic acid 63 on the metal-binding properties of the recombinant N-lobe of human serum transferrin.	Aspartic Acid	24-37	transferrin	Homo sapiens	114-125
9154935-1	1997	Mutations of the aspartic acid residue at position 63 of the N-lobe of human serum transferrin substantially alter the metal ion- and anion-binding properties of the protein.	Aspartic Acid	17-30	transferrin	Homo sapiens	83-94
9177684-2	1997	A peptide substrate, Ac-Gly-Glu-Ala-Gly-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-Tyr-Thr-Trp-Thr-L ys (biotin) -OH (Sub-1), was hydrolyzed by a recombinant NS3 proteinase fused with maltose binding protein (MBP-NS3) into a product with a free amino moiety at the N-terminus.	Aspartic Acid	40-43	KRAS proto-oncogene, GTPase	Homo sapiens	151-154
9177684-2	1997	A peptide substrate, Ac-Gly-Glu-Ala-Gly-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-Tyr-Thr-Trp-Thr-L ys (biotin) -OH (Sub-1), was hydrolyzed by a recombinant NS3 proteinase fused with maltose binding protein (MBP-NS3) into a product with a free amino moiety at the N-terminus.	Aspartic Acid	40-43	KRAS proto-oncogene, GTPase	Homo sapiens	206-209
9151295-4	1997	CCK-8S (10 microM) induced a approximately 3-fold increase in extracellular dynorphin B, aspartate and glutamate levels, while GABA levels were only slightly increased.	Aspartic Acid	89-98	cholecystokinin	Rattus norvegicus	0-3
9275284-2	1997	The beta CK2tes open reading frame comprises nucleotide stretches encoding for the conservative polypeptide motifs characteristic for the CK2 beta-subunit including the Glu/Asp rich region responsible for regulation of CK2, C-terminal fragment responsible for binding to the catalytic alpha-subunit, and "zinc finger" motif.	Aspartic Acid	173-176	casein kinase IIalpha	Drosophila melanogaster	9-12
9136756-2	1997	The measurement of binding of arginine-glycine-aspartic acid (RGD) peptidomimetics to GPIIb/IIIa on platelets is a key for the further understanding of ligand-receptor interactions and, thus, the design of new antagonists.	Aspartic Acid	47-60	integrin subunit alpha 2b	Homo sapiens	86-91
9184912-4	1997	The majority of Xid anti-PC antibodies exhibit an Asp--&gt;Gly95H replacement at the V-D junction.	Aspartic Acid	50-53	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	16-19
9109506-4	1997	The predicted amino acid sequence demonstrates that PTP NE-6 contains a single catalytic domain that diverges from the consensus protein tyrosine phosphatase catalytic domain by expressing an aspartate instead of the conserved alanine residue in the catalytic site.	Aspartic Acid	192-201	protein tyrosine phosphatase, receptor type N2	Rattus norvegicus	52-60
9109506-7	1997	These data demonstrate that the inactivity of native PTP NE-6 toward p-nitrophenyl phosphate is due to the divergent aspartate in the catalytic site and not to variant amino acids within the phosphatase domain.	Aspartic Acid	117-126	protein tyrosine phosphatase, receptor type N2	Rattus norvegicus	53-61
9186907-0	1997	Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: identification of the catalytically active serine, aspartic acid, and histidine residues.	Aspartic Acid	133-146	lipase A, lysosomal acid type	Homo sapiens	6-55
9186907-0	1997	Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: identification of the catalytically active serine, aspartic acid, and histidine residues.	Aspartic Acid	133-146	lipase F, gastric type	Homo sapiens	66-80
9151295-8	1997	Thus, the present results indicate that cortical CCK release exerts a stimulatory modulation on cortical dynorphin B and aspartate release via the CCKB receptor subtype, and on glutamate release via both CCKA and CCKB receptor subtypes.	Aspartic Acid	121-130	cholecystokinin	Rattus norvegicus	49-52
9179843-6	1997	In addition, a mutant LTB with a single Gly-33--&gt;Asp substitution that completely lacked affinity for both GM1 and non-GM1 glycosphingolipids could still bind to receptors in the intestinal cell membranes and to polyglycosylceramides.	Aspartic Acid	52-55	lymphotoxin-beta	Oryctolagus cuniculus	22-25
9168138-7	1997	A protein encoded by the WS-3 gene has an R-G-D (Arg-Gly-Asp) motif in the N-terminal region, which seems to confer adhesive properties to macromolecular proteins like fibronectin.	Aspartic Acid	57-60	dynactin subunit 6	Homo sapiens	25-29
9207844-1	1997	As in many bacterial species, the first enzymatic reaction of the aspartate-family pathway in plants is mediated by several isozymes of aspartate kinase (AK) that are subject to feedback inhibition by the end-product amino acids lysine or threonine.	Aspartic Acid	66-75	Aspartate kinase family protein	Arabidopsis thaliana	136-152
9207844-1	1997	As in many bacterial species, the first enzymatic reaction of the aspartate-family pathway in plants is mediated by several isozymes of aspartate kinase (AK) that are subject to feedback inhibition by the end-product amino acids lysine or threonine.	Aspartic Acid	66-75	Aspartate kinase family protein	Arabidopsis thaliana	154-156
9125501-5	1997	An energy decomposition analysis indicates that specific MDH residues (Arg-81, Arg-87, Asn-119, Asp-150, and Arg-153) in the vicinity of the substrate make significant energetic contributions to the stabilization of proton transfer and destabilization of hydride transfer.	Aspartic Acid	96-99	malic enzyme 1	Homo sapiens	57-60
9175714-2	1997	The 2- to 3-fold higher activities in adult male mice compared with adult female mice were decreased to the female levels by neonatal pretreatment with monosodium glutamate (MSG) or monosodium aspartate (MSA), either of which is known to reduce circulating GH levels.	Aspartic Acid	182-202	growth hormone	Mus musculus	257-259
9175714-2	1997	The 2- to 3-fold higher activities in adult male mice compared with adult female mice were decreased to the female levels by neonatal pretreatment with monosodium glutamate (MSG) or monosodium aspartate (MSA), either of which is known to reduce circulating GH levels.	Aspartic Acid	204-207	growth hormone	Mus musculus	257-259
9168138-7	1997	A protein encoded by the WS-3 gene has an R-G-D (Arg-Gly-Asp) motif in the N-terminal region, which seems to confer adhesive properties to macromolecular proteins like fibronectin.	Aspartic Acid	57-60	fibronectin 1	Homo sapiens	168-179
9150382-7	1997	One of these regions is within the kinase domain"s activation loop, where FGFR-1, but not FGFR-4, bears a key aspartate residue.	Aspartic Acid	110-119	fibroblast growth factor receptor 1	Mus musculus	74-80
9144530-8	1997	The results showed that Asn-47 and Asp-47 decreased the bioactivity of these mutants by 50- and 700-fold respectively, while the Kd to its high affinity receptors was increased 180- and 90-fold respectively, compared to IL-2.	Aspartic Acid	35-38	interleukin 2	Homo sapiens	220-224
9092666-4	1997	Two libraries of human EGF variants displayed on phage were constructed in which the aspartic acid residue at position 46 or the arginine residue at position 41 were randomised.	Aspartic Acid	85-98	epidermal growth factor	Homo sapiens	23-26
9128144-1	1997	Previous studies have revealed the functional importance of the negatively charged amino-acid residue Asp-290 of the phenobarbital-inducible dog liver cytochrome P-450 (P-450) 2B11 (Harlow, G.R.	Aspartic Acid	102-105	Cytochrome P450 1A1	Canis lupus familiaris	151-167
9126601-5	1997	Also, our preparation demonstrated expected biological properties of OPN including adhesion of both endothelial and vascular smooth muscle cells to OPN in a dose- and Arg-Gly-Asp-dependent manner.	Aspartic Acid	175-178	secreted phosphoprotein 1	Bos taurus	69-72
9181551-9	1997	In conclusion, BSP mediated attachment of osteoblastic cells to hydroxyapatite, and this activity could be accomplished only by the poly-Glu sequence and the Arg-Gly-Asp sequence.	Aspartic Acid	166-169	integrin binding sialoprotein	Homo sapiens	15-18
9094134-7	1997	Preference for Asp at the -2 peptide position is mediated by Tyr-77 of nNOS.	Aspartic Acid	15-18	nitric oxide synthase 1	Homo sapiens	71-75
9098855-3	1997	Although there was no protection with the control LacZ virus, the ornithine transcarbamylase (OTC)-containing vector provided partial protection from both behavioral symptoms (ataxia, seizures, and abnormal response to sound) and biochemical abnormalities (ammonium, aspartate, alanine, and glutamine) within 24 h and complete protection by 48 h. Mortality was also decreased.	Aspartic Acid	267-276	ornithine transcarbamylase	Mus musculus	94-97
9126601-5	1997	Also, our preparation demonstrated expected biological properties of OPN including adhesion of both endothelial and vascular smooth muscle cells to OPN in a dose- and Arg-Gly-Asp-dependent manner.	Aspartic Acid	175-178	secreted phosphoprotein 1	Bos taurus	148-151
9194172-5	1997	The chimera that contained a glycine in lieu of the aspartic acid present in native onconase (position 26 in the chimera) exhibited enzymatic activity more characteristic of EDN than native onconase and was considerably more active with respect to both RNase activity and cellular cytotoxicity than recombinant onconase.	Aspartic Acid	52-65	ribonuclease A family member 2	Homo sapiens	174-177
9079670-0	1997	Conversion of serine to aspartate imitates phosphorylation-induced changes in the structure and function of microtubule-associated protein tau.	Aspartic Acid	24-33	microtubule-associated protein tau	Rattus norvegicus	108-142
9115986-2	1997	The aspartate-99 of secreted phospholipase A2 (PLA2) has been proposed to be critical for the catalytic mechanism and interfacial activation of PLA2.	Aspartic Acid	4-13	LOC104974671	Bos taurus	29-45
9126263-6	1997	The mutant alleles are recessive; i.e., when wild-type and asp mutants coinfect the same host cells, most DNA replication is poisoned by P2 Tin protein.	Aspartic Acid	59-62	Tin	Bacteriophage P2	140-143
9065444-7	1997	There is NMR spectral evidence suggesting that the Arg-Asp buttressing interaction observed in the Zif-268.DNA complex is also preserved in unbound Sp1f2 and Sp1f3.	Aspartic Acid	55-58	early growth response 1	Homo sapiens	99-106
9065453-2	1997	To investigate the role in catalysis and/or substrate binding of the Walker motif residues of rat testis fructose 6-phosphate, 2-kinase:fructose-2,6-bisphosphatase (Fru 6-P,2-kinase:Fru-2,6-Pase), we have constructed and characterized mutant enzymes of Asp-128, Thr-52, Asn-73, Thr-130, and Tyr-197.	Aspartic Acid	253-256	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	105-163
9178347-5	1997	-Thr-Val-Gly-Asp-, that is strictly conserved between characterized DBI species, indicating special restrictions on the structure.	Aspartic Acid	13-16	diazepam binding inhibitor, acyl-CoA binding protein	Gallus gallus	68-71
9148753-6	1997	MMP-7 cleaves DCN into three major fragments which have the N-termini Asp1-Glu-Ala-Ser-Gly, Glu2-Ala-Ser-Gly-Ile and Leu244-His-Leu-Asp-Asn.	Aspartic Acid	70-73	matrix metallopeptidase 7	Homo sapiens	0-5
9116019-12	1997	This very homologous region, located in the central portion of PEPCK, contains two highly conserved aspartic acids, Asp295 and Asp296, that are the only feasible metal binding ligands.	Aspartic Acid	100-114	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	63-68
9135136-2	1997	The location of the integrin binding sequence Arg-Gly-Asp (RGD) on human type 2 adenovirus (Ad2) was visualized by cryo-electron microscopy (cryo-EM) and image reconstruction using a mAb (DAV-1) which recognizes a linear epitope, IRGDTFATR.	Aspartic Acid	54-57	apolipoprotein E	Homo sapiens	92-95
9148753-6	1997	MMP-7 cleaves DCN into three major fragments which have the N-termini Asp1-Glu-Ala-Ser-Gly, Glu2-Ala-Ser-Gly-Ile and Leu244-His-Leu-Asp-Asn.	Aspartic Acid	70-73	decorin	Homo sapiens	14-17
9062131-5	1997	N-Terminal sequencing revealed that both the Mr 147,000 and 107,000 polypeptides had the same N-terminal sequence resulting from cleavage of aminopeptidase A by trypsin at the Lys-42-Asp-43 bond just outside the membrane-spanning hydrophobic region.	Aspartic Acid	183-186	glutamyl aminopeptidase	Homo sapiens	141-157
9067503-4	1997	A point mutation at codon 970 of the alpha-spectrin gene (GCT--&gt;GAT), that changes the encoded amino acid from an alanine to an aspartic acid, was identified in genomic DNA of affected patients.	Aspartic Acid	131-144	glycine-N-acyltransferase	Homo sapiens	67-70
9050838-3	1997	From a mutagenesis study of these invariant residues that was guided by our knowledge of the crystal structure of PTP1B, we have discovered a mutation of the invariant catalytic acid (Asp-181 in PTP1B) that converts an extremely active enzyme into a "substrate trap."	Aspartic Acid	184-187	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	114-119
9050838-3	1997	From a mutagenesis study of these invariant residues that was guided by our knowledge of the crystal structure of PTP1B, we have discovered a mutation of the invariant catalytic acid (Asp-181 in PTP1B) that converts an extremely active enzyme into a "substrate trap."	Aspartic Acid	184-187	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	195-200
9050841-5	1997	We find that the intraring intersubunit interaction between Asp-41 and Thr-522 changes little during the allosteric transitions of GroEL, indicating that the hydrogen bond between these residues is maintained.	Aspartic Acid	60-63	heat shock protein family D (Hsp60) member 1	Homo sapiens	131-136
9042931-9	1997	Our results indicate that the combination DQA1#52 (Arg predisposing) DQB1#57 (Asp protective), which has been proposed as an important IDDM agent, does not include all the predisposing elements.	Aspartic Acid	78-81	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	42-46
9042931-9	1997	Our results indicate that the combination DQA1#52 (Arg predisposing) DQB1#57 (Asp protective), which has been proposed as an important IDDM agent, does not include all the predisposing elements.	Aspartic Acid	78-81	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	69-73
9050852-9	1997	However, only one of them, Asp-435, was equally important for binding of Ang; the Ki increases produced by mutations of the others were 20- to 93-fold smaller for Ang than for RNase A.	Aspartic Acid	27-30	angiogenin	Homo sapiens	73-76
9050852-9	1997	However, only one of them, Asp-435, was equally important for binding of Ang; the Ki increases produced by mutations of the others were 20- to 93-fold smaller for Ang than for RNase A.	Aspartic Acid	27-30	angiogenin	Homo sapiens	163-166
9050852-9	1997	However, only one of them, Asp-435, was equally important for binding of Ang; the Ki increases produced by mutations of the others were 20- to 93-fold smaller for Ang than for RNase A.	Aspartic Acid	27-30	ribonuclease A family member 1, pancreatic	Homo sapiens	176-183
9063652-3	1997	Although an addition of L-Asp (0.1-100 mumol/l) caused a significant rise in GH release in a concentration-dependent manner, neither the individual amino acids contained in NEAA except L-Asp nor others (L-Leu, L-Phe, L-Gln, L-Met, and L-Arg) caused a rise in GH release when added alone to the medium.	Aspartic Acid	24-29	growth hormone	Capra hircus	77-79
9063652-3	1997	Although an addition of L-Asp (0.1-100 mumol/l) caused a significant rise in GH release in a concentration-dependent manner, neither the individual amino acids contained in NEAA except L-Asp nor others (L-Leu, L-Phe, L-Gln, L-Met, and L-Arg) caused a rise in GH release when added alone to the medium.	Aspartic Acid	24-29	growth hormone	Capra hircus	259-261
9118999-5	1997	ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes.	Aspartic Acid	119-122	NBL1, DAN family BMP antagonist	Homo sapiens	274-277
9038211-2	1997	We introduced one of these mutations, Asp-556 --&gt; Gly, into the rat LH/hCG receptor and demonstrated that the mutant receptor constitutively activated adenylate cyclase in transfected 293 T cells.	Aspartic Acid	38-41	chorionic gonadotropin subunit beta 5	Homo sapiens	74-77
9118999-5	1997	ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes.	Aspartic Acid	119-122	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
9062474-4	1997	An activating mutation of the TSH receptor gene in both the primary tumor and the lymph node metastasis was found, due to a base substitution at codon 633 (normal guanine at position 1896 replaced by cytosine CAC for GAC causing aspartic acid substitution by histidine).	Aspartic Acid	229-242	thyroid stimulating hormone receptor	Homo sapiens	30-42
12223636-3	1997	The polypeptide encoded by the AK/HSD gene comprises two linked key enzymes in the biosynthesis of aspartate-family amino acids.	Aspartic Acid	99-108	aspartate kinase-homoserine dehydrogenase ii	Arabidopsis thaliana	31-37
12223636-9	1997	The expression pattern of the A. thaliana AK/HSD-GUS reporter gene positively correlated with the levels of aspartate-family amino acids and was also very similar to the expression pattern of the endogenous tobacco AK/HSD mRNA as determined by in situ hybridization.	Aspartic Acid	108-117	aspartate kinase-homoserine dehydrogenase ii	Arabidopsis thaliana	42-48
9075934-2	1997	Using site-directed mutagenesis, residues on HLA-C that determine the locus specificity (alphaVal-76), allotype group specificity (a dimorphism alphaAsn-80/Lys-80), and affinity of NKIR binding (a second pair of dimorphisms, alphaAla-73, Asp-90 or alphaThr-73, Ala-90) have been identified.	Aspartic Acid	238-241	major histocompatibility complex, class I, C	Homo sapiens	45-50
9075934-2	1997	Using site-directed mutagenesis, residues on HLA-C that determine the locus specificity (alphaVal-76), allotype group specificity (a dimorphism alphaAsn-80/Lys-80), and affinity of NKIR binding (a second pair of dimorphisms, alphaAla-73, Asp-90 or alphaThr-73, Ala-90) have been identified.	Aspartic Acid	238-241	CD300 molecule like family member f	Homo sapiens	181-185
9219916-4	1997	We have taken a different approach and examined the naturally occurring codon 351 asp --&gt; tyr mutation in the LBD of ER to stimulate the expression of an endogenous target gene.	Aspartic Acid	82-85	estrogen receptor 1	Homo sapiens	120-122
9219916-6	1997	In this report we describe the regulation of transforming growth factor alpha (TGF alpha) mRNA by estradiol and the antiestrogens keoxifene and ICI 182,780 in our stable transfectants of ER-negative MDA-MB-231 breast cancer cells, which express either the wild-type (S30 cells) or codon 351 asp --&gt; tyr mutant ER (BC-2 cells).	Aspartic Acid	291-294	tumor necrosis factor	Homo sapiens	45-77
9219916-6	1997	In this report we describe the regulation of transforming growth factor alpha (TGF alpha) mRNA by estradiol and the antiestrogens keoxifene and ICI 182,780 in our stable transfectants of ER-negative MDA-MB-231 breast cancer cells, which express either the wild-type (S30 cells) or codon 351 asp --&gt; tyr mutant ER (BC-2 cells).	Aspartic Acid	291-294	transforming growth factor alpha	Homo sapiens	79-88
9098927-1	1997	B*2704 and B*2706 are two closely related HLA-B27 subtypes, which differ from the common B*2705 by the Asp &gt; Ser77, Val &gt; Glu152, and Ala &gt; Gly211 amino acid changes.	Aspartic Acid	103-106	major histocompatibility complex, class I, B	Homo sapiens	42-49
9098936-4	1997	In an African-American Black individual with the HLA phenotype A23.30;B58,63;Cw6;DR18,12;DR52;DQ5,2, we found a fourth example of this dimorphism: the new DQB1*0203 allele, that was identical to DQB1*0202 except for codon 57, which encodes aspartic acid and alanine respectively in the two alleles.	Aspartic Acid	240-253	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	155-159
9038140-9	1997	Furthermore, the C-terminal 51 amino acid residues, which are rich in serines and aspartic acids, are also required for the inducible degradation of IkappaBbeta.	Aspartic Acid	82-96	NFKB inhibitor beta	Homo sapiens	149-160
10374307-6	1997	HLA-DQ beta chain substitution of aspartate molecule was at position 57 (susceptic gene).	Aspartic Acid	34-43	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	0-3
9091313-0	1997	Identification of essential aspartic acid and histidine residues of hormone-sensitive lipase: apparent residues of the catalytic triad.	Aspartic Acid	28-41	lipase E, hormone sensitive type	Homo sapiens	68-92
9091313-2	1997	Recently, we have published a three-dimensional model for the C-terminal catalytic domain of HSL, having an alpha/beta-hydrolase fold and with Ser-423(1), Asp-703 and His-733 in the catalytic triad (Contreras et al.	Aspartic Acid	155-158	lipase E, hormone sensitive type	Homo sapiens	93-96
9048578-6	1997	While no evidence for positive interactions with the P3 residue emerged, Kex2 was found to discriminate against at least one residue Asp.	Aspartic Acid	133-136	kexin KEX2	Saccharomyces cerevisiae S288C	73-77
9030588-1	1997	Two amino acids before the first aspartate-rich motif solely determine eukaryotic farnesyl diphosphate synthase activity.	Aspartic Acid	33-42	farnesyl diphosphate synthase	Homo sapiens	82-111
9030612-1	1997	Previous studies have shown that fibrinogen can associate with endothelial cells via an Arg-Gly-Asp (RGD) recognition specificity.	Aspartic Acid	96-99	fibrinogen beta chain	Homo sapiens	33-43
9070923-6	1997	Mouse Casp7 encodes a putative 340-amino-acid polypeptide that contains all the known conserved residues required for protease function, including the QACRG sequence, aspartic acid residues for internal cleavage sites, and the residues required for substrate binding.	Aspartic Acid	167-180	caspase 7	Mus musculus	6-11
9080315-4	1997	Kinetic measurements have shown the guanase activity to have an apparent Michaelis constant of 24.5 microM and the AST activity of 11.1 and 0.18 mM for aspartate and oxoglutarate, respectively, at 37 degrees C in Tris-HCl buffer (pH 7.5).	Aspartic Acid	152-161	guanine deaminase	Homo sapiens	36-43
9080315-4	1997	Kinetic measurements have shown the guanase activity to have an apparent Michaelis constant of 24.5 microM and the AST activity of 11.1 and 0.18 mM for aspartate and oxoglutarate, respectively, at 37 degrees C in Tris-HCl buffer (pH 7.5).	Aspartic Acid	152-161	solute carrier family 17 member 5	Homo sapiens	115-118
9020120-0	1997	Molecular determinants of arg-gly-asp ligand specificity for beta3 integrins.	Aspartic Acid	34-37	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	61-66
9020091-6	1997	Specifically, after Gly40 and Thr45 in the putative effector domain of ARF1 were replaced with the equivalent Asp and Pro, respectively, from p3, functional interaction of the chimeric ARF1 with p5 was increased.	Aspartic Acid	110-113	ADP ribosylation factor 1	Homo sapiens	185-189
9020091-6	1997	Specifically, after Gly40 and Thr45 in the putative effector domain of ARF1 were replaced with the equivalent Asp and Pro, respectively, from p3, functional interaction of the chimeric ARF1 with p5 was increased.	Aspartic Acid	110-113	ADP ribosylation factor 1	Homo sapiens	71-75
9020120-10	1997	These results confirm that subtle changes in the amino acid composition immediately flanking the RGD or RYD motifs can have a profound effect on beta3 integrin specificity, most likely because they influence the juxtaposition of the arginine and aspartate side chains within the extended RGD loop sequence.	Aspartic Acid	246-255	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	145-150
9020189-19	1997	A phosducin mutant that mimics phosphorylated phosducin (phosducin Ser-73 --&gt; Asp) lacks this property and in fact recruits GRK3 to the membrane and potentiates desensitization.	Aspartic Acid	81-84	phosducin	Homo sapiens	2-11
9013608-7	1997	In an effort to further characterize the protein residues involved in interfacial catalysis, we have determined the high resolution (1.7 A) x-ray structure of the Class II Asp-49 phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus.	Aspartic Acid	172-175	LOC104974671	Bos taurus	179-195
9020189-19	1997	A phosducin mutant that mimics phosphorylated phosducin (phosducin Ser-73 --&gt; Asp) lacks this property and in fact recruits GRK3 to the membrane and potentiates desensitization.	Aspartic Acid	81-84	phosducin	Homo sapiens	46-55
9020189-19	1997	A phosducin mutant that mimics phosphorylated phosducin (phosducin Ser-73 --&gt; Asp) lacks this property and in fact recruits GRK3 to the membrane and potentiates desensitization.	Aspartic Acid	81-84	phosducin	Homo sapiens	46-55
9020189-19	1997	A phosducin mutant that mimics phosphorylated phosducin (phosducin Ser-73 --&gt; Asp) lacks this property and in fact recruits GRK3 to the membrane and potentiates desensitization.	Aspartic Acid	81-84	G protein-coupled receptor kinase 3	Homo sapiens	127-131
9012484-2	1997	An assay was developed for distinguishing type I CGbeta allelic genes beta7 and beta6, which possess a GCC codon corresponding to an alanine at position 117 of hCGbeta, from type II CGbeta genes beta8, beta5, and beta3 and its allele beta9, which possess a GAC codon corresponding to an aspartic acid at the same position.	Aspartic Acid	287-300	chorionic gonadotropin subunit beta 3	Homo sapiens	49-55
9063899-9	1997	The distinct structural feature of this archaeal ferredoxin lies in the zinc-binding center where the zinc ion is tetrahedrally ligated by four amino acid residues (His 16, His 19, and His 34 from the N-terminal extension, and Asp 76 from the core fold).	Aspartic Acid	227-230	4Fe-4S binding protein	Sulfurisphaera tokodaii str. 7	49-59
9023338-0	1997	The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate.	Aspartic Acid	130-139	adrenoceptor alpha 1B	Homo sapiens	30-57
9053451-4	1997	Analysis of 16 CD59 mutants with single, highly nonconservative substitutions suggests that CD59 has a single active site that includes Trp-40, Arg-53, and Glu-56 of the glycosylated, membrane-distal face of the disk-like extra-cellular domain and, possibly, Asp-24 positioned at the edge of the domain.	Aspartic Acid	259-262	CD59 molecule (CD59 blood group)	Homo sapiens	92-96
9017218-1	1997	The catalytic site of all dihydrofolate reductases contains an invariant carboxylic acid, equivalent to Asp-27 in Escherichia coli dihydrofolate reductase (ecDHFR).	Aspartic Acid	104-107	dihydrofolate reductase	Escherichia coli	156-162
9017218-9	1997	Because the carboxyl group of Asp-27 at the active site is the only ionizable group in the binding site, other groups, away from the catalytic site, must be responsible for the pH behavior of ecDHFR.	Aspartic Acid	30-33	dihydrofolate reductase	Escherichia coli	192-198
9020867-2	1997	This may be partly due to an unfavourable interaction between the P3 aspartate and Glu192 in the active site of thrombin.	Aspartic Acid	69-78	coagulation factor II, thrombin	Homo sapiens	112-120
9052571-8	1997	HLA-DR B1 alleles overrepresented in patients with inflammatory AAAs express a glutamine substitution at position 70, whereas alleles disfavored in the patient cohort express a negatively charged aspartic acid.	Aspartic Acid	196-209	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-9
9110362-1	1997	Single nucleotide substitutions are known to result in a different amino acid at one of four sites in cytochrome P4502C9 (CYP2C9) namely: residue 144: Arg/Cys; residue 358: Tyr/Cys; residue 359: Ile/Leu and residue 417: Gly/Asp.	Aspartic Acid	224-227	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	102-120
9110362-1	1997	Single nucleotide substitutions are known to result in a different amino acid at one of four sites in cytochrome P4502C9 (CYP2C9) namely: residue 144: Arg/Cys; residue 358: Tyr/Cys; residue 359: Ile/Leu and residue 417: Gly/Asp.	Aspartic Acid	224-227	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	122-128
8999905-5	1997	In general des-(B25-30)-[His-A8, Asp-B10, Tyr-B25 alpha-carboxamide]insulin binding correlated with insulin binding, suggesting that both peptides bound to the receptor in a similar manner.	Aspartic Acid	33-36	insulin	Homo sapiens	68-75
9048335-4	1997	Polystyrene beads coated with Arg-Gly-Asp (RGD)-containing peptide adhere to the surface of sublethally injured MPT cells but not to control, dextrose-treated cells, indicating that the beta 1 integrins present on the apical surface of the cell remain functional.	Aspartic Acid	38-41	hemoglobin, beta adult major chain	Mus musculus	186-192
9020867-4	1997	To investigate the importance of Glu192 and exosite-binding in modulating thrombin"s interactions with a P3 aspartate, peptidyl chloromethanes based on the sequence of the thrombin receptor (containing a P3 aspartate) have been synthesized and the kinetics of their inactivation of alpha-thrombin and the mutant Glu192--&gt;Gln determined.	Aspartic Acid	108-117	coagulation factor II, thrombin	Homo sapiens	74-82
9020867-4	1997	To investigate the importance of Glu192 and exosite-binding in modulating thrombin"s interactions with a P3 aspartate, peptidyl chloromethanes based on the sequence of the thrombin receptor (containing a P3 aspartate) have been synthesized and the kinetics of their inactivation of alpha-thrombin and the mutant Glu192--&gt;Gln determined.	Aspartic Acid	207-216	coagulation factor II, thrombin	Homo sapiens	74-82
9020867-7	1997	This exosite-binding peptide also increased the ki values of chloromethanes containing a P3 aspartate with both alpha-thrombin and the Glu192--&gt;Gln mutant.	Aspartic Acid	92-101	coagulation factor II, thrombin	Homo sapiens	118-126
9020867-3	1997	In Protein C activation and perhaps also thrombin receptor cleavage, binding of ligands at the anion-binding exosite of thrombin seems to improve the activity of thrombin with substrates containing a P3 aspartate.	Aspartic Acid	203-212	coagulation factor II, thrombin	Homo sapiens	41-49
9020867-3	1997	In Protein C activation and perhaps also thrombin receptor cleavage, binding of ligands at the anion-binding exosite of thrombin seems to improve the activity of thrombin with substrates containing a P3 aspartate.	Aspartic Acid	203-212	coagulation factor II, thrombin	Homo sapiens	120-128
9020867-3	1997	In Protein C activation and perhaps also thrombin receptor cleavage, binding of ligands at the anion-binding exosite of thrombin seems to improve the activity of thrombin with substrates containing a P3 aspartate.	Aspartic Acid	203-212	coagulation factor II, thrombin	Homo sapiens	120-128
8995368-7	1997	We investigated the role of putative active site residues Asp-alpha258, Glu-alpha307, Glu-alpha323, and Glu-alpha462 in the alpha subunit of Hex A.	Aspartic Acid	58-61	hexosaminidase subunit alpha	Homo sapiens	141-146
9016768-0	1997	Aspartate 196 in the first extracellular loop of the human VIP1 receptor is essential for VIP binding and VIP-stimulated cAMP production.	Aspartic Acid	0-9	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	59-63
9016768-0	1997	Aspartate 196 in the first extracellular loop of the human VIP1 receptor is essential for VIP binding and VIP-stimulated cAMP production.	Aspartic Acid	0-9	vasoactive intestinal peptide	Homo sapiens	59-62
9016768-0	1997	Aspartate 196 in the first extracellular loop of the human VIP1 receptor is essential for VIP binding and VIP-stimulated cAMP production.	Aspartic Acid	0-9	vasoactive intestinal peptide	Homo sapiens	90-93
9016768-4	1997	Since all mutated receptor proteins were expressed and delivered at the plasma membrane (immunofluorescence studies), it is concluded that the first extracellular loop of the human VIP1 receptor contains a highly conserved aspartate residue which is essential for VIP binding and VIP-stimulated cAMP production.	Aspartic Acid	223-232	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	181-185
9016768-4	1997	Since all mutated receptor proteins were expressed and delivered at the plasma membrane (immunofluorescence studies), it is concluded that the first extracellular loop of the human VIP1 receptor contains a highly conserved aspartate residue which is essential for VIP binding and VIP-stimulated cAMP production.	Aspartic Acid	223-232	vasoactive intestinal peptide	Homo sapiens	181-184
9016768-4	1997	Since all mutated receptor proteins were expressed and delivered at the plasma membrane (immunofluorescence studies), it is concluded that the first extracellular loop of the human VIP1 receptor contains a highly conserved aspartate residue which is essential for VIP binding and VIP-stimulated cAMP production.	Aspartic Acid	223-232	vasoactive intestinal peptide	Homo sapiens	264-267
9493968-5	1997	The cleavage occurs between Asp-214 and Gly-215, a site that is conserved in human, bovine, and chicken PARP.	Aspartic Acid	28-31	poly(ADP-ribose) polymerase 1	Homo sapiens	104-108
9013710-4	1997	Mutation of a single serine residue in p80 coilin to aspartate (S202D) also causes coiled bodies and splicing snRNPs to localize within nucleoli when the mutant is transiently transfected and expressed in HeLa cells.	Aspartic Acid	53-62	coilin	Homo sapiens	39-42
9006413-4	1997	We recently described a family with amyotrophic lateral sclerosis associated with a mutation in the superoxide dismutase 1 (SOD1) gene substituting an aspartate for an alanine (D9OA).	Aspartic Acid	151-160	superoxide dismutase 1	Homo sapiens	100-122
9006413-4	1997	We recently described a family with amyotrophic lateral sclerosis associated with a mutation in the superoxide dismutase 1 (SOD1) gene substituting an aspartate for an alanine (D9OA).	Aspartic Acid	151-160	superoxide dismutase 1	Homo sapiens	124-128
9215757-3	1997	A cluster of Asp and Tyr residues occurs also in a region of the platelet glycoprotein (GP) Ib alpha amino terminal domain known to be critically involved in vWF binding.	Aspartic Acid	13-16	glycoprotein Ib platelet subunit alpha	Homo sapiens	74-100
9215757-3	1997	A cluster of Asp and Tyr residues occurs also in a region of the platelet glycoprotein (GP) Ib alpha amino terminal domain known to be critically involved in vWF binding.	Aspartic Acid	13-16	von Willebrand factor	Homo sapiens	158-161
9112755-4	1997	The wild-type MARCKS and MRP peptides induced significant increases in the Ca2+ affinity of CaM (pCa 6.1 and 5.8, respectively, compared to 5.2, for CaM in the absence of bound peptides), whereas a modified MARCKS peptide, in which the four serine residues susceptible to phosphorylation in the wild-type sequence have been replaced with aspartate residues to mimic phosphorylation, had smaller effect (pCa 5.6).	Aspartic Acid	338-347	myristoylated alanine rich protein kinase C substrate	Homo sapiens	14-20
9112755-4	1997	The wild-type MARCKS and MRP peptides induced significant increases in the Ca2+ affinity of CaM (pCa 6.1 and 5.8, respectively, compared to 5.2, for CaM in the absence of bound peptides), whereas a modified MARCKS peptide, in which the four serine residues susceptible to phosphorylation in the wild-type sequence have been replaced with aspartate residues to mimic phosphorylation, had smaller effect (pCa 5.6).	Aspartic Acid	338-347	MARCKS like 1	Homo sapiens	25-28
9112755-4	1997	The wild-type MARCKS and MRP peptides induced significant increases in the Ca2+ affinity of CaM (pCa 6.1 and 5.8, respectively, compared to 5.2, for CaM in the absence of bound peptides), whereas a modified MARCKS peptide, in which the four serine residues susceptible to phosphorylation in the wild-type sequence have been replaced with aspartate residues to mimic phosphorylation, had smaller effect (pCa 5.6).	Aspartic Acid	338-347	calmodulin 1	Homo sapiens	92-95
9028826-0	1997	Hb Setif [alpha 94(G1)Asp--&gt;Tyr] in Malta.	Aspartic Acid	22-25	proline rich protein BstNI subfamily 3	Homo sapiens	16-21
9495316-5	1997	Flies bearing the aspartic acid eIF-2alpha mutant (HD) transgene displayed a slow growth phenotype and small body size.	Aspartic Acid	18-31	eukaryotic translation initiation factor 2 subunit alpha	Drosophila melanogaster	32-42
9504114-7	1997	The sequences determining peptide recognition and the induction of TH1 cells mediating the cellular autoimmune response are in positions DRB1-57 and 74 (an aspartic acid and a glutamic acid respectively, confer protection), modulated by D-57 in the DQ, 8 chain.	Aspartic Acid	156-169	major histocompatibility complex, class II, DR beta 1	Homo sapiens	137-141
9155591-4	1997	RESULTS: The histopathological damage in the liver, and the concanavalin A induced release of TNF alpha and IL6 were significantly inhibited by the synthetic Arg-Gly-Asp mimetic (p &lt; 0.001).	Aspartic Acid	166-169	tumor necrosis factor	Mus musculus	94-103
9155591-4	1997	RESULTS: The histopathological damage in the liver, and the concanavalin A induced release of TNF alpha and IL6 were significantly inhibited by the synthetic Arg-Gly-Asp mimetic (p &lt; 0.001).	Aspartic Acid	166-169	interleukin 6	Mus musculus	108-111
9338582-2	1997	Among seven unrelated Northern European kindreds with clinical TPI deficiency studied, a single missense mutation at codon 104 (GAG;Glu--&gt;GAC;Asp) predominated, accounting for 11/14 (79%) mutant alleles.	Aspartic Acid	145-148	triosephosphate isomerase 1	Homo sapiens	63-66
9420466-5	1997	For DRB1*0807, presumably generated by an Asp to Val change (GAT to GTT) at codon 57, strong selective pressures appear to be in operation, based on the high frequency (23%), and linkage disequilibrium patterns of this allele.	Aspartic Acid	42-45	major histocompatibility complex, class II, DR beta 1	Homo sapiens	4-8
9437709-5	1997	Python neurokinin A (His-Lys-Thr-Asp-Ser-Phe-Val-Gly- Leu-Met.NH2) is identical to human/chicken/alligator neurokinin A.	Aspartic Acid	33-36	tachykinin precursor 1	Homo sapiens	7-19
9027564-7	1997	Although the amino acid sequence of the GLUT4 COOH-terminal region is highly conserved among the species so far reported, one amino acid (Asp) of the region was replaced by His in bovine GLUT4.	Aspartic Acid	138-141	solute carrier family 2 member 4	Bos taurus	187-192
9029223-6	1997	Insulin concentrations were highest in IV and lowest in Asp and NG at onset of exercise, rapidly decreasing in IV and PO although remaining at higher levels than in Asp or NG.	Aspartic Acid	56-59	insulin	Homo sapiens	0-7
9029223-6	1997	Insulin concentrations were highest in IV and lowest in Asp and NG at onset of exercise, rapidly decreasing in IV and PO although remaining at higher levels than in Asp or NG.	Aspartic Acid	165-168	insulin	Homo sapiens	0-7
9120775-9	1997	These studies suggest that the glycoprotein IIb/IIIa complex, present on activated-platelets, may interact with fibronectin and vitronectin substrates through the Arg-Gly-Asp-dependent mechanism.	Aspartic Acid	171-174	fibronectin 1	Homo sapiens	112-123
9120775-9	1997	These studies suggest that the glycoprotein IIb/IIIa complex, present on activated-platelets, may interact with fibronectin and vitronectin substrates through the Arg-Gly-Asp-dependent mechanism.	Aspartic Acid	171-174	vitronectin	Homo sapiens	128-139
9125318-5	1996	DNA sequencing analysis of the receptor binding domain of the apo E gene in the 11 HLP III patients with discrepancies demonstrated the presence of six carriers of the epsilon 3(Arg136--&gt;Ser) allele and three carriers of the epsilon 2(Gly127--&gt;Asp) allele.	Aspartic Acid	250-253	apolipoprotein E	Homo sapiens	62-67
9037708-5	1997	Quantum mechanical/molecular mechanical calculations of the pathway of acetyl-CoA enolization within citrate synthase support the identification of Asp-375 as the catalytic base.	Aspartic Acid	148-151	citrate synthase	Homo sapiens	101-117
9205981-6	1997	The binding of fibrinogen to platelet Gp IIb/IIIa occurs via a specific amino acid sequence, arginine-glycine-aspartic acid.	Aspartic Acid	110-123	fibrinogen beta chain	Homo sapiens	15-25
9205981-6	1997	The binding of fibrinogen to platelet Gp IIb/IIIa occurs via a specific amino acid sequence, arginine-glycine-aspartic acid.	Aspartic Acid	110-123	integrin subunit alpha 2b	Homo sapiens	38-44
9000130-6	1996	Although p56 KKIAMRE and p42 KKIALRE contain the MAP kinase dual phosphorylation motif Thr-Xaa-Tyr (Thr-Asp-Tyr), phosphorylation on Thr and Tyr within this motif is not required for EGF-stimulated protein kinase activity.	Aspartic Acid	104-107	cyclin dependent kinase like 2	Homo sapiens	13-20
8973195-1	1996	The five cysteines closest to the carboxyl terminus of human ferrochelatase have been individually mutated to serine, histidine, or aspartate residues in an attempt to identify the protein ligands to the [2Fe-2S] cluster.	Aspartic Acid	132-141	ferrochelatase	Homo sapiens	61-75
8943276-10	1996	Trp-104 in the receptor, a key residue in the hormone-receptor interaction, has an altered conformation in the low affinity site enabling a favorable hydrogen bond to be formed with Asp-116 of the hormone.	Aspartic Acid	182-185	nuclear receptor subfamily 4 group A member 1	Homo sapiens	46-62
8943258-6	1996	Bax proteins expressing alanine substitutions of the highly conserved amino acids glycine 108 (G108) in BH1, tryptophan 158 (W158) in BH2, and glycine 67 and aspartic acid 68 (GD67-68) in BH3 as well as deletion of the most conserved amino acids in BH1 (Delta102-112) and BH2 (Delta151-159) and deletion of BH3 (Delta63-71) maintained their ability to accelerate chemotherapy-induced cell death.	Aspartic Acid	158-171	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
9000130-6	1996	Although p56 KKIAMRE and p42 KKIALRE contain the MAP kinase dual phosphorylation motif Thr-Xaa-Tyr (Thr-Asp-Tyr), phosphorylation on Thr and Tyr within this motif is not required for EGF-stimulated protein kinase activity.	Aspartic Acid	104-107	cyclin dependent kinase like 1	Homo sapiens	25-28
8962111-3	1996	Mutation at the equivalent position in the murine c-kit gene, involving a substitution of tyrosine for aspartic acid (D814Y), has been described in the mouse mastocytoma cell line P815.	Aspartic Acid	103-116	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	50-55
8962059-4	1996	Energetically important binding contacts at the interface with TF were identified in the first epidermal growth factor domain of VIIa (Gln-64, Ile-69, Phe-71, Arg-79) and in the protease domain (Arg-277, Met-306, Asp-309).	Aspartic Acid	213-216	coagulation factor III, tissue factor	Homo sapiens	63-65
8997197-7	1996	When the neutral asparagine residue within the second putative membrane-spanning domain of the ROMK channel was substituted with aspartic acid, the corresponding amino acid in IRK1, the degree of inward rectification was enhanced but Ba2+ block and single-channel inward conductance were unaffected.	Aspartic Acid	129-142	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	95-99
8997197-7	1996	When the neutral asparagine residue within the second putative membrane-spanning domain of the ROMK channel was substituted with aspartic acid, the corresponding amino acid in IRK1, the degree of inward rectification was enhanced but Ba2+ block and single-channel inward conductance were unaffected.	Aspartic Acid	129-142	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	176-180
9027334-4	1996	When residues 94-96 were neutral or contained 1-3 aspartates, LHR binding was reduced 6-100 fold but remained at least ten-fold greater than the negative control analog containing residues 94-117 derived from FSH.	Aspartic Acid	50-60	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	62-65
8931704-3	1996	The patients in this family showed a novel missense mutation in exon 5 of the PS1 gene (A to T change in codon 120, altering glutamine to aspartic acid).	Aspartic Acid	138-151	presenilin 1	Homo sapiens	78-81
8951564-14	1996	Photoactivated cross-linking studies indicated that potential binding residues are located just downstream of the active ATPase site (Asp 351) of SERCA 2, but SERCA 3 is devoid of this sequence.	Aspartic Acid	134-137	dynein axonemal heavy chain 8	Homo sapiens	121-127
8951564-14	1996	Photoactivated cross-linking studies indicated that potential binding residues are located just downstream of the active ATPase site (Asp 351) of SERCA 2, but SERCA 3 is devoid of this sequence.	Aspartic Acid	134-137	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	146-153
8958208-6	1996	We also tested the ability of IGFBP-2, a related binding protein which has an arginine-glycine-aspartate sequence but does not associate with integrin family members, to enhance IGF-I bioactivity.	Aspartic Acid	95-104	insulin-like growth factor-binding protein 2	Oryctolagus cuniculus	30-37
8978814-7	1996	Lamin A and C are cleaved into 47- and 37-kD fragments, respectively, and the site of proteolysis is mapped to a conserved aspartic acid residue at position 230.	Aspartic Acid	123-136	lamin A	Mus musculus	0-7
8969279-2	1996	IGF-I normally stimulated receptor autophosphorylation, IRS-I phosphorylation, and glycogen synthesis in cells expressing Asp 1048 IR.	Aspartic Acid	122-125	insulin-like growth factor 1	Rattus norvegicus	0-5
8969279-3	1996	However, the Asp 1048 IR inhibited IGF-I-stimulated thymidine uptake by 45% to 52% and amino acid uptake (aminoisobutyric acid [AIB]) by 58% in Asp 1048 IR cells.	Aspartic Acid	13-16	insulin receptor	Rattus norvegicus	22-24
8969279-3	1996	However, the Asp 1048 IR inhibited IGF-I-stimulated thymidine uptake by 45% to 52% and amino acid uptake (aminoisobutyric acid [AIB]) by 58% in Asp 1048 IR cells.	Aspartic Acid	13-16	insulin-like growth factor 1	Rattus norvegicus	35-40
8969279-3	1996	However, the Asp 1048 IR inhibited IGF-I-stimulated thymidine uptake by 45% to 52% and amino acid uptake (aminoisobutyric acid [AIB]) by 58% in Asp 1048 IR cells.	Aspartic Acid	13-16	insulin receptor	Rattus norvegicus	153-155
8969279-3	1996	However, the Asp 1048 IR inhibited IGF-I-stimulated thymidine uptake by 45% to 52% and amino acid uptake (aminoisobutyric acid [AIB]) by 58% in Asp 1048 IR cells.	Aspartic Acid	144-147	insulin receptor	Rattus norvegicus	22-24
8969279-3	1996	However, the Asp 1048 IR inhibited IGF-I-stimulated thymidine uptake by 45% to 52% and amino acid uptake (aminoisobutyric acid [AIB]) by 58% in Asp 1048 IR cells.	Aspartic Acid	144-147	insulin-like growth factor 1	Rattus norvegicus	35-40
8969279-3	1996	However, the Asp 1048 IR inhibited IGF-I-stimulated thymidine uptake by 45% to 52% and amino acid uptake (aminoisobutyric acid [AIB]) by 58% in Asp 1048 IR cells.	Aspartic Acid	144-147	insulin receptor	Rattus norvegicus	153-155
8969279-5	1996	The inhibition of mitogenesis and AIB uptake was restored with the amelioration of the impaired tyrosine kinase activity and Shc phosphorylation by the introduction of abundant wild-type IGF-IR in Asp 1048 IR cells.	Aspartic Acid	197-200	insulin receptor	Rattus norvegicus	191-193
8969279-5	1996	The inhibition of mitogenesis and AIB uptake was restored with the amelioration of the impaired tyrosine kinase activity and Shc phosphorylation by the introduction of abundant wild-type IGF-IR in Asp 1048 IR cells.	Aspartic Acid	197-200	insulin receptor	Rattus norvegicus	206-208
8969279-6	1996	These results suggest that the Asp 1048 IR causes a dominant negative effect on IGF-IR in transmitting signals to Shc and MAP kinase activation, which leads to decreased IGF-I-stimulated DNA synthesis, and that the kinase-defective insulin receptor does not affect IGF-I-stimulated IRS-I phosphorylation, which leads to the normal IGF-I-stimulated glycogen synthesis.	Aspartic Acid	31-34	insulin receptor	Rattus norvegicus	40-42
8969279-6	1996	These results suggest that the Asp 1048 IR causes a dominant negative effect on IGF-IR in transmitting signals to Shc and MAP kinase activation, which leads to decreased IGF-I-stimulated DNA synthesis, and that the kinase-defective insulin receptor does not affect IGF-I-stimulated IRS-I phosphorylation, which leads to the normal IGF-I-stimulated glycogen synthesis.	Aspartic Acid	31-34	insulin receptor	Rattus norvegicus	84-86
8969279-6	1996	These results suggest that the Asp 1048 IR causes a dominant negative effect on IGF-IR in transmitting signals to Shc and MAP kinase activation, which leads to decreased IGF-I-stimulated DNA synthesis, and that the kinase-defective insulin receptor does not affect IGF-I-stimulated IRS-I phosphorylation, which leads to the normal IGF-I-stimulated glycogen synthesis.	Aspartic Acid	31-34	insulin-like growth factor 1	Rattus norvegicus	80-85
8969279-6	1996	These results suggest that the Asp 1048 IR causes a dominant negative effect on IGF-IR in transmitting signals to Shc and MAP kinase activation, which leads to decreased IGF-I-stimulated DNA synthesis, and that the kinase-defective insulin receptor does not affect IGF-I-stimulated IRS-I phosphorylation, which leads to the normal IGF-I-stimulated glycogen synthesis.	Aspartic Acid	31-34	insulin-like growth factor 1	Rattus norvegicus	170-175
8969279-6	1996	These results suggest that the Asp 1048 IR causes a dominant negative effect on IGF-IR in transmitting signals to Shc and MAP kinase activation, which leads to decreased IGF-I-stimulated DNA synthesis, and that the kinase-defective insulin receptor does not affect IGF-I-stimulated IRS-I phosphorylation, which leads to the normal IGF-I-stimulated glycogen synthesis.	Aspartic Acid	31-34	insulin-like growth factor 1	Rattus norvegicus	170-175
8939882-2	1996	Since a highly conserved Glu in the catalytic region of these transferases is substituted with Gln at position 207 in RT6.1, we replaced the Gln with Glu, Asp, or Ala, by site-directed mutagenesis.	Aspartic Acid	155-158	ADP-ribosyltransferase 2b	Rattus norvegicus	118-121
8945558-3	1996	Two amino acid residues, Arg-136 and Asp-347, were identified as the residues binding to STa in the extracellular domain of pig STaR by site-directed mutagenesis and analysis of expression on 293T cells.	Aspartic Acid	37-40	steroidogenic acute regulatory protein	Sus scrofa	128-132
8938739-7	1996	In three independent experiments, in N-methyl-D-aspartate-lesioned animals, both striatal and hippocampal injuries were reduced in animals that had been infected with adenovirus that encoded Interleukin-1 receptor antagonist, in comparison with littermates infected with the control adenovirus (right striatal volume loss ranged from 16 to 24%, compared with 54-65% volume loss in control).	Aspartic Acid	48-57	interleukin 1 receptor antagonist	Rattus norvegicus	191-224
8939944-3	1996	The binding geometry is characterized primarily by two interaction sites: the naphthamidine group is fixed in the S1 pocket by a typical salt bridge to Asp-189, while the pyrrolidine ring binds in the unique aryl-binding site (S4) of fXa.	Aspartic Acid	152-155	coagulation factor X	Homo sapiens	234-237
8906836-6	1996	To test whether intracellular signal transduction occurs, an IFN-gamma variant was constructed with the carboxyl-terminal endoplasmic reticulum retention signal Lys-Asp-Glu-Leu (KDEL).	Aspartic Acid	165-168	interferon gamma	Mus musculus	61-70
8942999-5	1996	The mutation in the 25-RA cells resulted from a G-to-A transition in codon 443 of the SCAP gene, changing aspartic acid to asparagine.	Aspartic Acid	106-119	sterol regulatory element-binding protein cleavage-activating protein	Cricetulus griseus	86-90
8910515-7	1996	A variant of t-PA containing an aspartate residue at position 144, for example, exhibited a zymogenicity of 150, compared to a value of 9 for wild type t-PA and 250 for u-PA.	Aspartic Acid	32-41	plasminogen activator, tissue type	Homo sapiens	13-17
8953412-0	1996	Study of aspartate at residue 9 of HLA-C molecules in Japanese patients with psoriasis vulgaris.	Aspartic Acid	9-18	major histocompatibility complex, class I, C	Homo sapiens	35-40
8910515-7	1996	A variant of t-PA containing an aspartate residue at position 144, for example, exhibited a zymogenicity of 150, compared to a value of 9 for wild type t-PA and 250 for u-PA.	Aspartic Acid	32-41	plasminogen activator, tissue type	Homo sapiens	152-156
8910515-7	1996	A variant of t-PA containing an aspartate residue at position 144, for example, exhibited a zymogenicity of 150, compared to a value of 9 for wild type t-PA and 250 for u-PA.	Aspartic Acid	32-41	plasminogen activator, urokinase	Homo sapiens	169-173
8911275-1	1996	Osteopontin (OPN), an arginine-glycine-aspartate (RGD)-containing adhesive glycoprotein, is constitutively expressed in rat aorta and carotid arteries and is markedly elevated in response to vascular injury.	Aspartic Acid	39-48	secreted phosphoprotein 1	Rattus norvegicus	0-11
8911275-1	1996	Osteopontin (OPN), an arginine-glycine-aspartate (RGD)-containing adhesive glycoprotein, is constitutively expressed in rat aorta and carotid arteries and is markedly elevated in response to vascular injury.	Aspartic Acid	39-48	secreted phosphoprotein 1	Rattus norvegicus	13-16
8922600-1	1996	A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination.	Aspartic Acid	33-36	fibronectin 1	Homo sapiens	103-114
8898195-3	1996	Sterol resistance was traced to a G--&gt;A transition at codon 443 of SCAP, changing aspartic acid to asparagine.	Aspartic Acid	85-98	sterol regulatory element-binding protein cleavage-activating protein	Cricetulus griseus	70-74
8913624-2	1996	Linear and cyclic forms of the fibronectin (Fn) cell-binding domain peptide Arg-Gly-Asp (RGD) were covalently immobilized to glass, and Fn was adsorbed onto glass slides.	Aspartic Acid	84-87	fibronectin 1	Bos taurus	31-42
8913624-2	1996	Linear and cyclic forms of the fibronectin (Fn) cell-binding domain peptide Arg-Gly-Asp (RGD) were covalently immobilized to glass, and Fn was adsorbed onto glass slides.	Aspartic Acid	84-87	fibronectin 1	Bos taurus	44-46
8953412-1	1996	The frequency of aspartate at residue 9 (Asp-9) of HLA-C molecules was investigated among 75 Japanese patients with psoriasis vulgaris and 50 healthy controls.	Aspartic Acid	17-26	major histocompatibility complex, class I, C	Homo sapiens	51-56
8953412-1	1996	The frequency of aspartate at residue 9 (Asp-9) of HLA-C molecules was investigated among 75 Japanese patients with psoriasis vulgaris and 50 healthy controls.	Aspartic Acid	41-44	major histocompatibility complex, class I, C	Homo sapiens	51-56
8953412-2	1996	We developed a technique of polymerase chain reaction sequence-specific primer (PCR-SSP) amplification of genomic DNA for HLA-C alleles with a codon for Asp-9.	Aspartic Acid	153-156	major histocompatibility complex, class I, C	Homo sapiens	122-127
8953412-7	1996	Asp-9 is located on a beta sheet of alpha 1 domain of HLA-C molecule and influences the peptide binding of the C pocket of the groove together with Ala-73.	Aspartic Acid	0-3	major histocompatibility complex, class I, C	Homo sapiens	54-59
8900201-6	1996	However, CPP32 processes pro-Mch2alpha at three aspartate processing sites (Asp23, Asp179, and Asp193) to produce the large (p18) and small (p11) subunits of the mature Mch2alpha enzyme.	Aspartic Acid	48-57	caspase 3	Homo sapiens	9-14
9007014-9	1996	Sequence similarity to previously sequenced genes suggested that the products of orf4 and orf5 may work together to transport a molecule such as aspartate ion that may promote osmotolerance.	Aspartic Acid	145-154	putative polysaccharide deacetylase	Escherichia coli	81-85
9007014-9	1996	Sequence similarity to previously sequenced genes suggested that the products of orf4 and orf5 may work together to transport a molecule such as aspartate ion that may promote osmotolerance.	Aspartic Acid	145-154	plasmid maintenance protein	Escherichia coli	90-94
8863630-5	1996	The increase in intensity ratio was 32% in THF-Mn-ASP and 28% in Gd-DTPA.	Aspartic Acid	50-53	thin fur	Mus musculus	43-46
8938402-5	1996	This enzyme, encoded by the PUR7 gene, catalyzes aspartate addition at the alpha-amino group to the growing purine backbone.	Aspartic Acid	49-58	purin 7	Arabidopsis thaliana	28-32
8873604-7	1996	When the interaction of Na+ with the B2 receptor was prevented by exchanging a conserved aspartate in transmembrane domain II for asparagine the B2 receptor was also constitutively-activated in the absence of agonist.	Aspartic Acid	89-98	bradykinin receptor B2	Homo sapiens	37-48
8824206-0	1996	Mutagenesis of segment 487Phe-Ser-Arg-Asp-Arg-Lys492 of sarcoplasmic reticulum Ca2+-ATPase produces pumps defective in ATP binding.	Aspartic Acid	38-41	dynein axonemal heavy chain 8	Homo sapiens	84-90
8873604-7	1996	When the interaction of Na+ with the B2 receptor was prevented by exchanging a conserved aspartate in transmembrane domain II for asparagine the B2 receptor was also constitutively-activated in the absence of agonist.	Aspartic Acid	89-98	bradykinin receptor B2	Homo sapiens	145-156
8816444-0	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.	Aspartic Acid	17-30	eukaryotic translation initiation factor 4B	Homo sapiens	80-111
8912692-0	1996	Interaction of aspartic acid-104 and proline-287 with the active site of m-calpain.	Aspartic Acid	15-28	calpain 2	Homo sapiens	73-82
8855938-3	1996	The three independently determined thrombin/G17 psi complexes in the crystal asymmetric unit reveal novel interactions for the P2" and P3" residues-Pro-18f and Arg-19f, respectively-on the carboxyl-terminal side of the scissile bond and confirm previously observed interactions of the P1 (Arg-16f) through P10 (Asp-7f) positions on the amino-terminal side.	Aspartic Acid	311-314	coagulation factor II, thrombin	Bos taurus	35-43
8813154-5	1996	Overexpression of FN also suppressed the ability of the tumor cells to proliferate in soft agar, whereas the suppression was reversed by inclusion in soft agar of the Arg-Gly-Asp (RGD)-containing peptide and adhesion-blocking antibodies against the central cell-binding domain of FN.	Aspartic Acid	175-178	fibronectin 1	Homo sapiens	18-20
9015679-2	1996	The WHO DiaMond Molecular Epidemiology Sub-Project is testing the hypothesis that the geographic differences in IDDM incidence reflect population variation in the frequency of IDDM susceptibility genes (i.e., DQA1 and DQB1 alleles with sequences coding for arginine (R) in position 52 of the DQ alpha-chain, and an amino acid other than aspartic acid (ND) in position 57 of the DQ beta-chain, respectively) using a standardized case-control design.	Aspartic Acid	337-350	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	209-213
9015679-2	1996	The WHO DiaMond Molecular Epidemiology Sub-Project is testing the hypothesis that the geographic differences in IDDM incidence reflect population variation in the frequency of IDDM susceptibility genes (i.e., DQA1 and DQB1 alleles with sequences coding for arginine (R) in position 52 of the DQ alpha-chain, and an amino acid other than aspartic acid (ND) in position 57 of the DQ beta-chain, respectively) using a standardized case-control design.	Aspartic Acid	337-350	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	218-222
8908597-6	1996	Identical point mutations were detected in the transmembrane domain of p75NTR in the two melanoma lines with reduced p75NTR protein expression, which resulted in the substitution of the uncharged amino acid Gly for the negatively-charged Asp.	Aspartic Acid	238-241	nerve growth factor receptor	Homo sapiens	71-77
8908597-6	1996	Identical point mutations were detected in the transmembrane domain of p75NTR in the two melanoma lines with reduced p75NTR protein expression, which resulted in the substitution of the uncharged amino acid Gly for the negatively-charged Asp.	Aspartic Acid	238-241	nerve growth factor receptor	Homo sapiens	117-123
8816444-0	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.	Aspartic Acid	17-30	eukaryotic translation initiation factor 4B	Homo sapiens	113-118
8816444-0	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.	Aspartic Acid	17-30	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	158-162
8816444-6	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine, termed the DRYG domain, is sufficient for self-association of eIF4B, both in vitro and in vivo, and for interaction with the p170 subunit of eIF3.	Aspartic Acid	17-30	eukaryotic translation initiation factor 4B	Homo sapiens	127-132
8816444-6	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine, termed the DRYG domain, is sufficient for self-association of eIF4B, both in vitro and in vivo, and for interaction with the p170 subunit of eIF3.	Aspartic Acid	17-30	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	206-210
8798548-5	1996	Both nonmyristoylatable MARCKS and MARCKS in which the four serines in the PSD were mutated to aspartic acids, mimicking phosphorylation, exhibited decreased membrane affinity when compared to the fully myristoylated, wild-type, tetra-Ser protein or a myristoylated, tetra-Asn mutant.	Aspartic Acid	95-109	myristoylated alanine rich protein kinase C substrate	Gallus gallus	24-30
8884775-1	1996	The effect of cholecystokinin peptides on the release of dynorphin B, aspartate, glutamate, dopamine and GABA in the neostriatum and substantia nigra of the rat was investigated using in vivo microdialysis.	Aspartic Acid	70-79	cholecystokinin	Rattus norvegicus	14-29
8884775-2	1996	Sulphated cholecystokinin-8S in the dialysis perfusate (1-100 microM) induced a concentration-dependent increase in extracellular dynorphin B and aspartate levels, both in the neostriatum and substantia nigra.	Aspartic Acid	146-155	cholecystokinin	Rattus norvegicus	10-25
8884775-6	1996	Local cholecystokinin-4 (100 microM) produced a moderate, but significant, increase of extracellular dynorphin B and aspartate levels in the neostriatum and substantia nigra.	Aspartic Acid	117-126	cholecystokinin	Rattus norvegicus	6-21
8884775-12	1996	In the substantia nigra, however, the effect of cholecystokinin-8S on dynorphin B and aspartate levels was inhibited to a similar extent by both L-365,260 and L-364,718.	Aspartic Acid	86-95	cholecystokinin	Rattus norvegicus	48-63
8884775-14	1996	Taken together, these results suggest that cholecystokinin-8S modulates dynorphin B and aspartate release in the neostriatum and substantia nigra of the rat via different receptor mechanisms.	Aspartic Acid	88-97	cholecystokinin	Rattus norvegicus	43-58
8884775-15	1996	In the neostriatum, the effect of cholecystokinin-8S on dynorphin B and aspartate release is mediated via the cholecystokinin-B receptor subtype, while in the substantia nigra, cholecystokinin-8S modulates dynorphin B and aspartate release via both cholecystokinin-A and cholecystokinin-B receptor subtypes.	Aspartic Acid	72-81	cholecystokinin	Rattus norvegicus	34-49
8884775-15	1996	In the neostriatum, the effect of cholecystokinin-8S on dynorphin B and aspartate release is mediated via the cholecystokinin-B receptor subtype, while in the substantia nigra, cholecystokinin-8S modulates dynorphin B and aspartate release via both cholecystokinin-A and cholecystokinin-B receptor subtypes.	Aspartic Acid	72-81	cholecystokinin B receptor	Rattus norvegicus	110-136
8884775-15	1996	In the neostriatum, the effect of cholecystokinin-8S on dynorphin B and aspartate release is mediated via the cholecystokinin-B receptor subtype, while in the substantia nigra, cholecystokinin-8S modulates dynorphin B and aspartate release via both cholecystokinin-A and cholecystokinin-B receptor subtypes.	Aspartic Acid	72-81	cholecystokinin	Rattus norvegicus	110-125
8884775-15	1996	In the neostriatum, the effect of cholecystokinin-8S on dynorphin B and aspartate release is mediated via the cholecystokinin-B receptor subtype, while in the substantia nigra, cholecystokinin-8S modulates dynorphin B and aspartate release via both cholecystokinin-A and cholecystokinin-B receptor subtypes.	Aspartic Acid	72-81	cholecystokinin	Rattus norvegicus	110-125
8884775-15	1996	In the neostriatum, the effect of cholecystokinin-8S on dynorphin B and aspartate release is mediated via the cholecystokinin-B receptor subtype, while in the substantia nigra, cholecystokinin-8S modulates dynorphin B and aspartate release via both cholecystokinin-A and cholecystokinin-B receptor subtypes.	Aspartic Acid	222-231	cholecystokinin	Rattus norvegicus	34-49
8884775-15	1996	In the neostriatum, the effect of cholecystokinin-8S on dynorphin B and aspartate release is mediated via the cholecystokinin-B receptor subtype, while in the substantia nigra, cholecystokinin-8S modulates dynorphin B and aspartate release via both cholecystokinin-A and cholecystokinin-B receptor subtypes.	Aspartic Acid	222-231	cholecystokinin B receptor	Rattus norvegicus	110-136
8805707-6	1996	The structure reveals a fold that has not been reported for any other serine protease, and an active site consisting of a novel catalytic triad in which the third member is a histidine instead of an aspartic acid, or possibly a catalytic tetrad consisting of a serine, two histidines and an aspartic acid.	Aspartic Acid	199-212	coagulation factor II, thrombin	Homo sapiens	70-85
8805707-6	1996	The structure reveals a fold that has not been reported for any other serine protease, and an active site consisting of a novel catalytic triad in which the third member is a histidine instead of an aspartic acid, or possibly a catalytic tetrad consisting of a serine, two histidines and an aspartic acid.	Aspartic Acid	291-304	coagulation factor II, thrombin	Homo sapiens	70-85
8808622-5	1996	This phosphate is then sequentially transferred to Sln1p-Asp-1144, then to Ypd1p-His64, and finally to Ssk1p-Asp554.	Aspartic Acid	57-60	histidine kinase	Saccharomyces cerevisiae S288C	51-56
8923737-7	1996	Hal3p contains an essential acidic domain rich in aspartates at its carboxyl terminus.	Aspartic Acid	50-60	phosphopantothenoylcysteine decarboxylase complex subunit SIS2	Saccharomyces cerevisiae S288C	0-5
8798548-5	1996	Both nonmyristoylatable MARCKS and MARCKS in which the four serines in the PSD were mutated to aspartic acids, mimicking phosphorylation, exhibited decreased membrane affinity when compared to the fully myristoylated, wild-type, tetra-Ser protein or a myristoylated, tetra-Asn mutant.	Aspartic Acid	95-109	myristoylated alanine rich protein kinase C substrate	Gallus gallus	35-41
8808622-5	1996	This phosphate is then sequentially transferred to Sln1p-Asp-1144, then to Ypd1p-His64, and finally to Ssk1p-Asp554.	Aspartic Acid	57-60	Ypd1p	Saccharomyces cerevisiae S288C	75-80
8806601-7	1996	This suggests that aspartic acid-37 and threonine-61 are important in the specificity of 11-cis retinol dehydrogenase for NAD+.	Aspartic Acid	19-32	retinol dehydrogenase 5	Homo sapiens	89-117
8808622-5	1996	This phosphate is then sequentially transferred to Sln1p-Asp-1144, then to Ypd1p-His64, and finally to Ssk1p-Asp554.	Aspartic Acid	57-60	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	103-108
8798452-6	1996	Bax proteins expressing alanine substitutions of the highly conserved amino acids glycine 108 in BH1, tryptophan 151 and 158 in BH2, and glycine 67 and aspartic acid 68 in BH3 retained their ability to promote chemotherapy-induced cell death that was inhibited by Bcl-XL and to form heterodimers with Bcl-XL.	Aspartic Acid	152-165	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
8779726-3	1996	The response patterns of the intracellular Ca2+ increase depend upon the identity of a single amino acid, aspartate (at position 854) or threonine (at position 840), located within the G-protein-interacting domains of mGluR1alpha and mGluR5a, respectively.	Aspartic Acid	106-115	carbonic anhydrase 2	Homo sapiens	43-46
8822954-9	1996	Several amino acid substitutions were identified in the proximity of the catalytically important amino acid residues such as Ser/Asp 159/160, Asp341, and Lys518, which have been identified in the structural analysis of the pig GPI.	Aspartic Acid	129-132	glucose-6-phosphate isomerase	Sus scrofa	227-230
8792713-4	1996	Retrospectively, a K-ras point mutation at codon 12 from GGT (glycine) to GAT (aspartic acid) was detected in the PPJ collected endoscopically 3 yr and 6 months earlier, as well as in the PPJ when PC was diagnosed and in the resected tumor tissue.	Aspartic Acid	79-92	KRAS proto-oncogene, GTPase	Homo sapiens	19-24
21143275-4	1996	Asp(281) and Lys(199) of the rat AT(1) receptor ion-pair with Arg(2) and the Phe(3) alpha-COOH of angiotensin II (AngII), respectively, and the Asp(281) /Arg(2) interaction is critical for full agonist activity.	Aspartic Acid	0-3	angiotensinogen	Rattus norvegicus	98-112
8913654-4	1996	RESULTS: Human TAP preferentially translocated analogues with residues leucine, isoleucine, methionine and arginine as the carboxy-terminal amino acids, whereas analogues with aspartic acid and serine were translocated poorly.	Aspartic Acid	176-189	filamin B	Homo sapiens	15-18
8913654-5	1996	The binding affinity to HLA-B*2705 of the poorly translocated aspartic acid and serine analogues was about 100-fold less compared to the parent HLA-B27 binding peptide.	Aspartic Acid	62-75	major histocompatibility complex, class I, B	Homo sapiens	24-29
8913654-5	1996	The binding affinity to HLA-B*2705 of the poorly translocated aspartic acid and serine analogues was about 100-fold less compared to the parent HLA-B27 binding peptide.	Aspartic Acid	62-75	major histocompatibility complex, class I, B	Homo sapiens	144-151
21143275-13	1996	Asp(1) of AngII forms an ion-pair with His(183), which stabilizes the receptor-bound conformation of AngII but is not critical for receptor activation.	Aspartic Acid	0-3	angiotensinogen	Rattus norvegicus	10-15
21143275-13	1996	Asp(1) of AngII forms an ion-pair with His(183), which stabilizes the receptor-bound conformation of AngII but is not critical for receptor activation.	Aspartic Acid	0-3	angiotensinogen	Rattus norvegicus	101-106
8816895-14	1996	Only one MS case (8%) showed K-ras mutation (codon 13 GGC &gt; GAC; glycine &gt; aspartate), which is in contrast to 2 of the TS cases (15%), showing codon 12 mutations.	Aspartic Acid	81-90	KRAS proto-oncogene, GTPase	Homo sapiens	29-34
8804314-8	1996	Replacement of a valine (V68) in the ETS domain of SAP1a by aspartic acid (as found in c-Ets-1, Elk-1, and Net) enhanced ternary complex formation by more than 60-fold.	Aspartic Acid	60-73	ETS transcription factor ELK4	Homo sapiens	51-55
8804314-8	1996	Replacement of a valine (V68) in the ETS domain of SAP1a by aspartic acid (as found in c-Ets-1, Elk-1, and Net) enhanced ternary complex formation by more than 60-fold.	Aspartic Acid	60-73	ETS proto-oncogene 1, transcription factor	Homo sapiens	87-94
8804314-8	1996	Replacement of a valine (V68) in the ETS domain of SAP1a by aspartic acid (as found in c-Ets-1, Elk-1, and Net) enhanced ternary complex formation by more than 60-fold.	Aspartic Acid	60-73	ETS transcription factor ELK1	Homo sapiens	96-101
8947586-6	1996	DNA sequence analysis revealed a mutation in the ligand binding region of retinoic acid receptor alpha in the HL-60/RA cells in which a glycine was replaced by an aspartic acid.	Aspartic Acid	163-176	retinoic acid receptor alpha	Homo sapiens	74-102
8884646-6	1996	Especially, DQB1*0503 and DQB1*0602 alleles carrying aspartic acid at position 57 and glycine at position 70 are increased significantly in EOP.	Aspartic Acid	53-66	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	12-16
8884646-6	1996	Especially, DQB1*0503 and DQB1*0602 alleles carrying aspartic acid at position 57 and glycine at position 70 are increased significantly in EOP.	Aspartic Acid	53-66	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	26-30
8702858-1	1996	Apoptosis is executed by cysteine proteases belonging to the CED-3/ICE family, which, unlike other mammalian cysteine proteases, cleave their substrates following aspartate residues.	Aspartic Acid	163-172	Cell death protein 3 subunit p17	Caenorhabditis elegans	61-66
8896178-8	1996	The sequence of the DQB1*0203 allele, associated with DR3, differs from DQB1*0201 by only one nucleotide substitution (C--&gt;A) in the second position of codon 57, resulting in an Ala to Asp change.	Aspartic Acid	188-191	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	20-24
8883274-9	1996	In contrast, the abnormal fibrin polymerization of fibrinogen gamma 330 Asp--&gt;Val was barely improved at increasing calcium concentrations.	Aspartic Acid	72-75	fibrinogen beta chain	Homo sapiens	51-61
8688099-2	1996	Aspartate was shown to induce a large membrane current sensitive to N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists in Purkinje cells from mice lacking functional NMDA receptors (NR1(-/-)).	Aspartic Acid	0-9	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	193-196
8702765-1	1996	The Arg-Gly-Asp (RGD) sequence within the third complementarity-determining region (CDR3) of the heavy chain (H3) is responsible for the binding of the recombinant murine Fab molecules, AP7 and PAC1.1, to the platelet integrin alphaIIbbeta3.	Aspartic Acid	12-15	cerebellar degeneration-related 3	Mus musculus	84-88
8855358-2	1996	An aspartate- and glutamate-rich portion of hirudin plays an important part in its tight binding to thrombin through a ladder of salt bridges, and these residues have previously been mutated to asparagine or glutamine.	Aspartic Acid	3-12	coagulation factor II, thrombin	Homo sapiens	100-108
8702765-1	1996	The Arg-Gly-Asp (RGD) sequence within the third complementarity-determining region (CDR3) of the heavy chain (H3) is responsible for the binding of the recombinant murine Fab molecules, AP7 and PAC1.1, to the platelet integrin alphaIIbbeta3.	Aspartic Acid	12-15	dual specificity phosphatase 2	Mus musculus	194-198
8925838-3	1996	Replacement of the highly conserved Gly418 residue, located within the flanking region of the fourth Ca(2+)-binding domain of GPIIb, with a negatively charged Asp residue resulted in marked reduction in the ability to bind divalent cations.	Aspartic Acid	159-162	integrin subunit alpha 2b	Homo sapiens	126-131
8718893-0	1996	Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates.	Aspartic Acid	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-61
8709147-9	1996	Syk, not belonging to the Src-like PTK family, revealed a distinct substrate requirement for aspartic acid in position -1 and glutamic acid in position +1.	Aspartic Acid	93-106	spleen associated tyrosine kinase	Homo sapiens	0-3
8702602-6	1996	cPLA2 contains a catalytic aspartic acid motif common to the subtilisin family of serine proteases.	Aspartic Acid	27-40	phospholipase A2 group IVA	Homo sapiens	0-5
8702602-12	1996	Arg-200, Ser-228, and Asp-549 are conserved in cPLA2 from six species and also in four nonmammalian phospholipase B enzymes.	Aspartic Acid	22-25	phospholipase A2 group IVA	Homo sapiens	47-52
8702602-13	1996	Our results, supported by circular dichroism, provide evidence that Asp-549 and Arg-200 are critical to the enzyme"s function and suggest that the cPLA2 catalytic center is novel.	Aspartic Acid	68-71	phospholipase A2 group IVA	Homo sapiens	147-152
8702471-0	1996	Reengineering the nucleotide cofactor specificity of the RecA protein by mutation of aspartic acid 100.	Aspartic Acid	85-98	RAD51 recombinase	Homo sapiens	57-61
8877763-6	1996	Pretreatment isolates encoding mutations at RT codon 215 or encoding codon 123 asp were associated with both significantly greater CD4 lymphocyte depletion and shorter survival.	Aspartic Acid	79-82	CD4 molecule	Homo sapiens	131-134
8769411-5	1996	Nonetheless, this asparagine residue appears to constitute an important component of the catalase PTS, in that replacement with aspartate abolished peroxisomal targeting (as did deletion of the COOH-terminal four residues).	Aspartic Acid	128-137	catalase	Homo sapiens	89-97
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Aspartic Acid	306-315	Pex5p	Saccharomyces cerevisiae S288C	89-94
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Aspartic Acid	306-315	peroxisomal biogenesis factor 5	Homo sapiens	131-144
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Aspartic Acid	306-315	catalase	Homo sapiens	197-205
8765746-3	1996	The deduced product of the Xenopus Sox gene (xSox-11) consisted of the standard domains of an HMG box, glycine/alanine-rich region and glutamic acid/aspartic acid-rich region and may be involved in the control of transcription.	Aspartic Acid	149-162	SRY-box 3 L homeolog	Xenopus laevis	45-52
8754806-4	1996	Substitutions at position 650 indicated that not only Glu but also Asp and, to a lesser extent, Gln and Leu result in pronounced constitutive activation of FGFR3.	Aspartic Acid	67-70	fibroblast growth factor receptor 3	Homo sapiens	156-161
8663403-6	1996	Mutagenesis of this serine to an aspartic acid resulted in an increase in DNA binding and transcriptional activity of MEF2C comparable to that observed when this site was phosphorylated, suggesting that phosphorylation augments DNA binding activity by introducing negative charge.	Aspartic Acid	33-46	myocyte enhancer factor 2C	Homo sapiens	118-123
8695668-2	1996	In general, the acidic group is an aspartate, Asp177 in human pancreatic lipase, but glutamate is found in some lipases.	Aspartic Acid	35-44	pancreatic lipase	Homo sapiens	62-79
8695668-3	1996	Previously, we demonstrated that site-specific mutagenesis of Asp177 to Glu177 produced a mutant human pancreatic lipase with near normal activity against triolein, thereby, raising questions about the role of Asp177 in the catalytic triad and about the evolutionary pressure which selected Asp over Glu in the catalytic mechanism.	Aspartic Acid	62-65	pancreatic lipase	Homo sapiens	103-120
8695668-8	1996	These findings demonstrated decreased conformational stability of the mutant lipase and provided an explanation for the preference of aspartate in the catalytic triad of human pancreatic lipase.	Aspartic Acid	134-143	pancreatic lipase	Homo sapiens	176-193
8752926-2	1996	Here we demonstrate that the I-Ak molecule preferentially binds peptides that contain negatively charged amino acids at the primary anchor position (Asp or Glu at P1), and that I-Ak can also bind peptides with polar residues at P1 (Cys, Ser, Asn, Gin, or Thr), although with lower affinity.	Aspartic Acid	149-152	aurora kinase A	Mus musculus	29-33
8661145-4	1996	The 919-codon open reading frame of human PWP2 belongs to the family of genes that contain tryptophan-aspartate (WD) repeats; other than its yeast counterpart, PWP2 is most closely homologous to the beta subunits of the trimeric G-protein family and may putatively be involved in signal transduction.	Aspartic Acid	102-111	PWP2 small subunit processome component	Homo sapiens	42-46
8663439-6	1996	CPP32 activation is blocked by cell-permeable inhibitors of aspartate-directed, cysteine proteases, suggesting that pro-CPP32 is cleaved by active CPP32 or by other ICE family members.	Aspartic Acid	60-69	caspase 3	Homo sapiens	0-5
8662505-4	1996	The proline residue Pro1 forms a salt bridge with a conserved, buried aspartate residue (Asp51), which suggests that the amino terminus of the protein rearranges upon proteolytic maturation.	Aspartic Acid	70-79	lamin A/C	Homo sapiens	20-24
8752926-3	1996	This preference for a negatively charged anchor residue is so pronounced that polyalanine peptides containing a single Asp can bind to I-Ak.	Aspartic Acid	119-122	aurora kinase A	Mus musculus	135-139
8752926-4	1996	Eight naturally processed peptides were found to use an Asp, as demonstrated by a drop in the I-Ak binding affinity of these peptides after Ala substitution.	Aspartic Acid	56-59	aurora kinase A	Mus musculus	94-98
8752927-3	1996	Engineered mAb constructs that express germ-line or mutated V(H) genes show that somatic mutations introducing aspartic acid in or adjacent to CDRH2 play a key role in insulin binding.	Aspartic Acid	111-124	insulin	Homo sapiens	168-175
8663439-6	1996	CPP32 activation is blocked by cell-permeable inhibitors of aspartate-directed, cysteine proteases, suggesting that pro-CPP32 is cleaved by active CPP32 or by other ICE family members.	Aspartic Acid	60-69	caspase 3	Homo sapiens	120-125
8663439-6	1996	CPP32 activation is blocked by cell-permeable inhibitors of aspartate-directed, cysteine proteases, suggesting that pro-CPP32 is cleaved by active CPP32 or by other ICE family members.	Aspartic Acid	60-69	caspase 3	Homo sapiens	120-125
8663439-6	1996	CPP32 activation is blocked by cell-permeable inhibitors of aspartate-directed, cysteine proteases, suggesting that pro-CPP32 is cleaved by active CPP32 or by other ICE family members.	Aspartic Acid	60-69	caspase 1	Homo sapiens	165-168
8660692-0	1996	Active-site topologies of human CYP2D6 and its aspartate-301 --&gt; glutamate, asparagine, and glycine mutants.	Aspartic Acid	47-56	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	32-38
17180094-4	1996	CED-3 and seven of its currently known mammalian homologues cleave their substrates after an aspartate residue, a property shared only by the cytotoxic T cell (CTL) protease granzyme B which is necessary for the CTL-mediated killing of target cells.	Aspartic Acid	93-102	intraflagellar transport 43	Homo sapiens	0-5
17180094-4	1996	CED-3 and seven of its currently known mammalian homologues cleave their substrates after an aspartate residue, a property shared only by the cytotoxic T cell (CTL) protease granzyme B which is necessary for the CTL-mediated killing of target cells.	Aspartic Acid	93-102	granzyme B	Homo sapiens	174-184
8663249-4	1996	However, other 5-HT2A receptor ligands like lysergic acid diethylamide (LSD), in which the amine nitrogen is embedded in a heterocycle, or N,N-dimethyl 5-HT, in which the side chain is a tertiary amine, are found in the computational simulations to interact with the aspartate but not with the serine, due mainly to steric hindrance.	Aspartic Acid	267-276	5-hydroxytryptamine receptor 2A	Homo sapiens	15-30
8805307-5	1996	One clue to the identity of the physiological substrate(s) activated by granzyme B comes from its unusual specificity for cleaving synthetic substrates after aspartate residues.	Aspartic Acid	158-167	granzyme B	Homo sapiens	72-82
8805307-6	1996	Members of the ICE/CED-3 family of cysteine proteases are prime candidates as they are important apoptotic effectors and are expressed as zymogens, which can be processed to form active heterodimeric enzymes after cleavage at specific aspartate residues.	Aspartic Acid	235-244	Cell death protein 3 subunit p17	Caenorhabditis elegans	19-24
8818798-6	1996	Feeding ASP-250 to young pigs increased their sera IGF-I concentrations by 24.8% (P &lt; .001).	Aspartic Acid	8-11	insulin like growth factor 1	Sus scrofa	51-56
8663002-1	1996	Fibronectin has been shown to bind to integrin alphaIIbbeta3 in Arg-Gly-Asp (RGD)-dependent and -independent manners.	Aspartic Acid	72-75	fibronectin 1	Homo sapiens	0-11
8774538-4	1996	Like many members of the integrin family, alpha v beta 3 recognizes the sequence Arg-Gly-Asp (RGD) in its ligands, and other molecules that contain this sequence will complete with the natural ligands (such as vitronectin) for binding.	Aspartic Acid	89-92	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	50-56
8700125-2	1996	Mutation of a membrane-embedded aspartate residue, highly conserved among G protein-coupled receptors, in the alpha 2AAR to asparagine (D79N alpha 2AAR) results in selective uncoupling of the receptor to K+ currents but retention of inhibition of cAMP production and of voltage-sensitive Ca2+ currents when expressed in AtT20 anterior pituitary cells in culture.	Aspartic Acid	32-41	adrenergic receptor, alpha 2a	Mus musculus	110-120
8700125-2	1996	Mutation of a membrane-embedded aspartate residue, highly conserved among G protein-coupled receptors, in the alpha 2AAR to asparagine (D79N alpha 2AAR) results in selective uncoupling of the receptor to K+ currents but retention of inhibition of cAMP production and of voltage-sensitive Ca2+ currents when expressed in AtT20 anterior pituitary cells in culture.	Aspartic Acid	32-41	adrenergic receptor, alpha 2a	Mus musculus	141-151
8755488-6	1996	Further, we demonstrate that the inhibitory effect of AEBSF is specific for A beta proteins starting at Aspartate 1, suggesting that AEBSF directly inhibits beta-secretase, the Methionine-Aspartate (Met-Asp)-cleaving enzyme.	Aspartic Acid	104-113	amyloid beta precursor protein	Homo sapiens	76-82
8662867-7	1996	By mutagenesis, we showed that two differences (methionine instead of tyrosine at position 70; lysine instead of aspartate or glutamate at position 285) explain the low sensitivity of Bungarus AChE to peripheral site inhibitors, compared to the Torpedo or mammalian AChEs.	Aspartic Acid	113-122	acetylcholinesterase	Rattus norvegicus	193-197
8672487-0	1996	Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.	Aspartic Acid	57-67	adenosine deaminase	Mus musculus	77-96
8672487-1	1996	Two adjacent aspartates, Asp 295 and Asp 296, playing major roles in the reaction catalyzed by mouse adenosine deaminase (mADA) were altered using site-directed mutagenesis.	Aspartic Acid	25-28	adenosine deaminase	Mus musculus	101-120
8672487-1	1996	Two adjacent aspartates, Asp 295 and Asp 296, playing major roles in the reaction catalyzed by mouse adenosine deaminase (mADA) were altered using site-directed mutagenesis.	Aspartic Acid	25-28	adenosine deaminase	Mus musculus	122-126
8670173-11	1996	Papain-digested pig colonic mucin contained 11% protein per mg of glycoprotein and was rich in serine, threonine, glutamate and aspartate.	Aspartic Acid	128-137	LOC100508689	Homo sapiens	28-33
8672487-1	1996	Two adjacent aspartates, Asp 295 and Asp 296, playing major roles in the reaction catalyzed by mouse adenosine deaminase (mADA) were altered using site-directed mutagenesis.	Aspartic Acid	37-40	adenosine deaminase	Mus musculus	101-120
8672487-1	1996	Two adjacent aspartates, Asp 295 and Asp 296, playing major roles in the reaction catalyzed by mouse adenosine deaminase (mADA) were altered using site-directed mutagenesis.	Aspartic Acid	13-23	adenosine deaminase	Mus musculus	101-120
8672487-1	1996	Two adjacent aspartates, Asp 295 and Asp 296, playing major roles in the reaction catalyzed by mouse adenosine deaminase (mADA) were altered using site-directed mutagenesis.	Aspartic Acid	37-40	adenosine deaminase	Mus musculus	122-126
8672487-10	1996	These results and others discussed below are in agreement with the postulated role of the adjacent aspartates in the catalytic mechanism for mADA.	Aspartic Acid	99-109	adenosine deaminase	Mus musculus	141-145
8672487-1	1996	Two adjacent aspartates, Asp 295 and Asp 296, playing major roles in the reaction catalyzed by mouse adenosine deaminase (mADA) were altered using site-directed mutagenesis.	Aspartic Acid	13-23	adenosine deaminase	Mus musculus	122-126
8649776-2	1996	By using recombination PCR in vitro mutagenesis, we introduced point mutations into the codon 273 of wild-type (wt) p53 (pC53-SN3) from Arg to His (pC53-273H [273H]), Asp (273D), Pro (273P), Lys (273K), Leu (273L) or Thr (273T), and compared their biological and biochemical activities with wt p53 and cancer-derived 175H, 248W and 273H/309S.	Aspartic Acid	167-170	tumor protein p53	Homo sapiens	116-119
8799888-0	1996	The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.	Aspartic Acid	21-30	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	110-116
8650229-4	1996	We have extended this investigation to another neuronal nicotinic receptor (alpha3/beta4), and found that a homologous residue in the beta4 subunit, Asp-268, played a similar role in coupling.	Aspartic Acid	149-152	basic helix-loop-helix family member e23 L homeolog	Xenopus laevis	76-88
8652539-4	1996	The mass of both fractions by mass spectral analysis was 22 721 daltons, and N-terminal amino acid sequences were identical to the first four amino acids of apo A-I (Asp, Glu, Pro, Pro).	Aspartic Acid	166-169	apolipoprotein A1	Homo sapiens	157-164
8649353-0	1996	An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons.	Aspartic Acid	3-12	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	54-83
8687409-2	1996	In contrast with the wild-type alpha GL-PLAP, a mutant, in which Asp at the cleavage/attachment site of GPI was replaced by Trp, failed to become a GPI-linked mature form and was retained as a precursor form within the cell [Oda, Cheng, Saku, Takami, Sohda, Misumi, Ikehara and Millan (1994) Biochem.	Aspartic Acid	65-68	leucyl and cystinyl aminopeptidase	Rattus norvegicus	40-44
8652789-7	1996	The nmr pattern for 3 showed a remarkable similarity with that for various Arg-Tyr-Asp containing peptides, a sequence that is crucial for the adhesion properties of the Leishmania gp63 glycoprotein.	Aspartic Acid	83-86	leishmanolysin like peptidase	Homo sapiens	181-185
8725286-4	1996	Inhibition of fibronectin matrix formation by the inclusion of Arg-Gly-Asp-containing peptides, which compete with fibronectin for binding to the cell surface alpha 5 beta 1 integrin receptors, abolished the proliferation effects of FGF-2.	Aspartic Acid	71-74	fibronectin 1	Gallus gallus	14-25
8725286-4	1996	Inhibition of fibronectin matrix formation by the inclusion of Arg-Gly-Asp-containing peptides, which compete with fibronectin for binding to the cell surface alpha 5 beta 1 integrin receptors, abolished the proliferation effects of FGF-2.	Aspartic Acid	71-74	fibronectin 1	Gallus gallus	115-126
8725286-4	1996	Inhibition of fibronectin matrix formation by the inclusion of Arg-Gly-Asp-containing peptides, which compete with fibronectin for binding to the cell surface alpha 5 beta 1 integrin receptors, abolished the proliferation effects of FGF-2.	Aspartic Acid	71-74	fibroblast growth factor 2	Gallus gallus	233-238
8983941-9	1996	On comparison of the amino acid compositions of the isoforms with that of the identical 9 kDa gamma D-crystallin fragment, the isoforms showed relatively lower amino contents of Asp, Arg, Leu and Tyr residues suggesting modifications of these residues in the isoforms.	Aspartic Acid	178-181	crystallin gamma D	Homo sapiens	94-112
8675302-5	1996	We found that a single amino acid substitution (glycine to aspartic acid) in the putative third outer loop greatly reduced Rck-mediated serum resistance and eukaryotic cell invasion.	Aspartic Acid	59-72	resistance to complement killing	Salmonella enterica subsp. enterica serovar Typhimurium	123-126
8832375-9	1996	In addition, we have found that ras-p21 and rap-M proteins are superimposable in the region 96-110 except at Asp 105.	Aspartic Acid	109-112	H3 histone pseudogene 16	Homo sapiens	36-39
8832375-11	1996	Both segments differ in structure from that of the rap-1A segment at Asp 108, implicating this residue as also being important in determining the activity of the protein.	Aspartic Acid	69-72	RAP1A, member of RAS oncogene family	Homo sapiens	51-57
8799825-7	1996	Cell-binding fibronectin fragments (type III repeats 6-10) containing the Arg-Gly-Asp (RGD) sequence blocked both nodule initiation and maturation, whether or not they contained a functional synergy site.	Aspartic Acid	82-85	fibronectin 1	Rattus norvegicus	13-24
8632167-2	1996	We have isolated and purified a brain-derived activity that cleaves the synthetic peptide substrate SEVKMDAEF between methionine and aspartate residues, as required to generate the amino-terminus of beta-amyloid peptide.	Aspartic Acid	133-142	amyloid beta precursor protein	Homo sapiens	199-219
8661197-9	1996	Asp, but not Pro, demonstrated very high enrichments in apo B-100 (P &lt; 0.001), reflecting distinct intracellular compartmentation.	Aspartic Acid	0-3	apolipoprotein B	Homo sapiens	56-65
8649576-4	1996	The results suggested that increased CSF aspartate and glutamate concentrations, as well as decreased taurine concentrations, may occur in some persons with more advanced symptoms of DAT.	Aspartic Acid	41-50	solute carrier family 6 member 3	Homo sapiens	183-186
8649353-2	1996	Sixteen glutamate and aspartate residues, located in the first two thirds of the putative extracellular loop of the NR1A subunit, were individually mutated.	Aspartic Acid	22-31	nodal homolog 1 L homeolog	Xenopus laevis	116-120
8643556-7	1996	Rat EC-SOD carrying an Asp --&gt; Val mutation is tetrameric and has a high heparin affinity, while mouse EC-SOD with a Val --&gt; Asp mutation is dimeric and has lost its high heparin affinity.	Aspartic Acid	23-26	superoxide dismutase 3	Rattus norvegicus	4-10
8862555-6	1996	Single amino acid substitutions of aspartic acid and serine by alanine at H55 of CDR2 and at H95 of CDR3 respectively and of tyrosine by phenylalanine at H97 and L96 of CDR3, significantly reduced the binding affinity for the TAG72 antigen by 20-, 8-, 16- and 45-fold respectively.	Aspartic Acid	35-48	cerebellar degeneration related protein 2	Homo sapiens	81-85
8862555-6	1996	Single amino acid substitutions of aspartic acid and serine by alanine at H55 of CDR2 and at H95 of CDR3 respectively and of tyrosine by phenylalanine at H97 and L96 of CDR3, significantly reduced the binding affinity for the TAG72 antigen by 20-, 8-, 16- and 45-fold respectively.	Aspartic Acid	35-48	CDR3	Homo sapiens	100-104
8658052-9	1996	Because in the antigen-stimulated acute infection spleen or granuloma cultures the co-stimulatory effect by FN was abrogated by the tripeptide (RGD) arg-gly asp, and anti alpha 5 beta 1 antibody, enhancement is attributed to signalling via the alpha 5 beta 1 integrin receptor of lymphocytes.	Aspartic Acid	157-160	fibronectin 1	Mus musculus	108-110
8822581-7	1996	The triplet GAT, coding for the amino acid residue gamma 364, was replaced by CAT, resulting in the substitution of Asp-->His.	Aspartic Acid	116-119	glycine-N-acyltransferase	Homo sapiens	12-15
8643556-7	1996	Rat EC-SOD carrying an Asp --&gt; Val mutation is tetrameric and has a high heparin affinity, while mouse EC-SOD with a Val --&gt; Asp mutation is dimeric and has lost its high heparin affinity.	Aspartic Acid	131-134	superoxide dismutase 3, extracellular	Mus musculus	106-112
8647267-3	1996	Two aspartate residues in this region are identified as critical determinants of the neurotoxin"s specificity.	Aspartic Acid	4-13	neurotoxin	Clostridium botulinum	85-95
8662771-5	1996	Thus, in addition to 8 tandemly arranged ligand binding repeats, the five-domain receptor contains an O-linked sugar region and the internalization signal, Phe-Asp-Asn-Pro-Val-Tyr, typical for all LDLR gene family members.	Aspartic Acid	160-163	low density lipoprotein receptor	Gallus gallus	197-201
8647806-7	1996	Another mutant, DAB389 IL-2(Q514D), in which a Gln residue at position 514 was changed to an Asp, was 2000-fold less cytotoxic than wild type DAB389 IL-2.	Aspartic Acid	93-96	interleukin 2	Homo sapiens	23-27
8621599-6	1996	Using peptides corresponding to J-domain sequence, we show that a peptide containing the highly conserved His-Pro-Asp sequence at positions 34-36 in the J-domain competes off YDJ1 stimulation of Hsp70 ATPase activity.	Aspartic Acid	114-117	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	175-179
8647260-5	1996	Mutations to Asp, Gln or Val all lead to a lower affinity for tissue factor by decreasing the rate of association, in the case of the Val mutant by a factor of 200, as measured by surface plasmon resonance.	Aspartic Acid	13-16	coagulation factor III, tissue factor	Homo sapiens	62-75
8780030-4	1996	In vitro, the metalloprotease cleaves the methionine-aspartic acid bond in a 10 amino acid synthetic peptide, indicating that it could generate the N-terminus of amyloid beta protein, and generates amyloidogenic fragments from full-length recombinant amyloid beta-precursor protein.	Aspartic Acid	53-66	amyloid beta precursor protein	Homo sapiens	162-174
8780030-4	1996	In vitro, the metalloprotease cleaves the methionine-aspartic acid bond in a 10 amino acid synthetic peptide, indicating that it could generate the N-terminus of amyloid beta protein, and generates amyloidogenic fragments from full-length recombinant amyloid beta-precursor protein.	Aspartic Acid	53-66	amyloid beta precursor protein	Homo sapiens	251-263
8732685-3	1996	Mutation of a highly conserved aspartic acid in the second transmembrane domain of the rLHR (designated rLHR-D383N) does not affect hCG binding but impairs signal transduction.	Aspartic Acid	31-44	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	87-91
8732685-3	1996	Mutation of a highly conserved aspartic acid in the second transmembrane domain of the rLHR (designated rLHR-D383N) does not affect hCG binding but impairs signal transduction.	Aspartic Acid	31-44	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	104-108
8665848-2	1996	One of these proteases, granzyme B, has an unusual substrate site preference for Asp residues, a property that it shares with members of the emerging interleukin-1beta-converting enzyme (ICE)/CED-3 family of proteases.	Aspartic Acid	81-84	granzyme B	Homo sapiens	24-34
8665848-2	1996	One of these proteases, granzyme B, has an unusual substrate site preference for Asp residues, a property that it shares with members of the emerging interleukin-1beta-converting enzyme (ICE)/CED-3 family of proteases.	Aspartic Acid	81-84	caspase 1	Homo sapiens	150-185
8665848-2	1996	One of these proteases, granzyme B, has an unusual substrate site preference for Asp residues, a property that it shares with members of the emerging interleukin-1beta-converting enzyme (ICE)/CED-3 family of proteases.	Aspartic Acid	81-84	caspase 1	Homo sapiens	187-190
8722626-7	1996	The effect of fibronectin was inhibited by hexapeptides that contained the integrin-recognizing Arg-Gly-Asp sequence.	Aspartic Acid	104-107	fibronectin 1	Mus musculus	14-25
8641983-6	1996	Mutational types of K-ras at codon 12 in PC were aspartic acid (Asp) in nine cases, both Asp and cysteine in one case, and arginine in one case.	Aspartic Acid	49-62	KRAS proto-oncogene, GTPase	Homo sapiens	20-25
8641983-6	1996	Mutational types of K-ras at codon 12 in PC were aspartic acid (Asp) in nine cases, both Asp and cysteine in one case, and arginine in one case.	Aspartic Acid	64-67	KRAS proto-oncogene, GTPase	Homo sapiens	20-25
8628286-4	1996	The second form is identical to p85 and p85/AS53 except for a 24-nucleotide insert between the SH2 domains that results in a replacement of aspartic acid 605 with nine amino acids, adding two potential serine phosphorylation sites in the vicinity of the known serine autophosphorylation site (Ser-608).	Aspartic Acid	140-153	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	32-35
8628286-4	1996	The second form is identical to p85 and p85/AS53 except for a 24-nucleotide insert between the SH2 domains that results in a replacement of aspartic acid 605 with nine amino acids, adding two potential serine phosphorylation sites in the vicinity of the known serine autophosphorylation site (Ser-608).	Aspartic Acid	140-153	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	40-43
8608574-7	1996	Direct sequence analysis of the K-ras oncogene revealed the mutation at codon 12 substituting the wild-type glycine (GGT) for aspartic acid (GAT) in all cancerous lesions of patients with PBM.	Aspartic Acid	126-139	KRAS proto-oncogene, GTPase	Homo sapiens	32-37
8610462-5	1996	Substitution of the second arginine in its nuclear localization signal (P648RRRV) with aspartic acid rendered nsP2 totally cytoplasmic.	Aspartic Acid	87-100	reticulon 2	Homo sapiens	110-114
8622865-2	1996	We have constructed c-Fos mutants with these serines changed to aspartic acid residues (FosD) to mimic phosphorylation or to alanine residues (FosA) to prevent phosphorylation.	Aspartic Acid	64-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	20-25
8621556-4	1996	The functional implication of this residue and the role of glutamate 386 in the HELVH(385-389) motif of APA have been investigated by replacing these residues with an aspartate (Asp-386, Asp-408) or an alanine (Ala-386, Ala-408) by site-directed mutagenesis.	Aspartic Acid	167-176	glutamyl aminopeptidase	Mus musculus	104-107
8621556-4	1996	The functional implication of this residue and the role of glutamate 386 in the HELVH(385-389) motif of APA have been investigated by replacing these residues with an aspartate (Asp-386, Asp-408) or an alanine (Ala-386, Ala-408) by site-directed mutagenesis.	Aspartic Acid	187-190	glutamyl aminopeptidase	Mus musculus	104-107
8605210-0	1996	Active site of bee venom phospholipase A2: the role of histidine-34, aspartate-64 and tyrosine-87.	Aspartic Acid	69-78	phospholipase A2 group IB	Homo sapiens	25-41
8786430-2	1996	Tat proteins containing mutations in the Arg-Gly-Asp (RGD) cell adhesion motif or a deletion of the cysteine-rich domain had no effect on neuronal morphology.	Aspartic Acid	49-52	tyrosine aminotransferase	Homo sapiens	0-3
8727210-6	1996	Our results suggest a strong association of alloimmunization with a cluster of HLA DR molecules sharing a particular polymorphic amino acid sequence at position 69-70 (Glu-Asp encoded by GAA-GAC nucleotide sequence) of the DR beta 1 chain (RR = 2.95, RR = 5.70 when patients were homozygous for this sequence), and a negative association with the DRB1*0301 allele (2.1% vs. 28%; RR = 0.08).	Aspartic Acid	172-175	major histocompatibility complex, class II, DR beta 1	Homo sapiens	347-351
8807192-0	1996	The type III connecting segment of fibronectin contains an aspartic acid residue that regulates the rate of binding to integrin alpha 4 beta 1.	Aspartic Acid	59-72	fibronectin 1	Homo sapiens	35-46
8735845-5	1996	On the other hand, when X = alpha MeTrp, its optimal N-protecting group was 2Adoc and its configuration was preferentially D. In the newly synthesized compounds, 13: 2Adoc-D-alpha MeTrp-Phg-Asp-NalN(CH3)2 and 16: 2Adoc-D-alpha MeTrp-Phg-Asp-NalNH2 had the best CCK-B receptor affinities (KI = 3.5 and 3.4 nM, respectively) and were selected for further biological evaluation.	Aspartic Acid	190-193	cholecystokinin B receptor	Rattus norvegicus	261-275
8605870-2	1996	CPP32, a cysteine protease, was shown previously to cleave SREBP-1 and SREBP-2 in vitro at an aspartic acid between the basic helix-loop-helix leucine zipper domain and the first trans-membrane domain, liberating a transcriptionally active fragment.	Aspartic Acid	94-107	sterol regulatory element-binding protein 1	Cricetulus griseus	59-66
8738655-2	1996	Isomerization of aspartic acid bonds at residues 1 and 7 renders A beta more prone to aggregate and form extended structure as it was shown by in vivo and in vitro studies.	Aspartic Acid	17-30	amyloid beta precursor protein	Homo sapiens	65-71
8738655-7	1996	mAb 6E10, raised against unmodified A beta recognizes only the unmodified decapeptide or the peptide isomerized at the first aspartic acid in a conformation-dependent manner, but does not recognize the mid-chain isomerized or diisomerized decapeptide in any circumstance.	Aspartic Acid	125-138	amyloid beta precursor protein	Homo sapiens	36-42
8743562-5	1996	MTSP-1 hydrolyzed tert-butyloxycarbonyl (Boc)-Asp(OBzl)Pro-Arg-amino-4-methyl-coumaryl-7-amide (MCA) and Boc-Ile-Glu-Gly-Arg-MCA faster than Boc-Phe-Ser-Arg-MCA.	Aspartic Acid	46-49	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	0-6
11725090-5	1996	The antagonist-binding pocket of the human 5-HT(1A)R is inferred from the interaction sites of pindolol with the receptor model: (1) the ionic interaction between the protonated amine of the ligand and the side chain of the conserved Asp-116, located in TMH 3; and (2) the hydrogen bonds between the ether oxygen and the hydroxyl group of the ligand and Asn-385, located in TMH 7.	Aspartic Acid	234-237	5-hydroxytryptamine receptor 1A	Homo sapiens	43-50
8865333-5	1996	Absorption of sucrose and leucine were higher by rats fed on HUR-137 diet and similarly, more aspartate was absorbed when fed on HUR-15 diet as demonstrated by both the methods.	Aspartic Acid	94-103	ELAV like RNA binding protein 1	Rattus norvegicus	129-132
8637902-4	1996	The importance of the conserved aspartic acid (D92 in VHR and D181 in PTP1) in both chemical steps was established.	Aspartic Acid	32-45	dual specificity phosphatase 3	Homo sapiens	54-57
8637902-7	1996	Steady- and presteady-state kinetics, as well as NMR analysis of the double mutant D92N/S131A (VHR), suggested that the conserved aspartic acid functions as a general base during intermediate hydrolysis.	Aspartic Acid	130-143	dual specificity phosphatase 3	Homo sapiens	95-98
8639500-4	1996	In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34.	Aspartic Acid	134-137	arginyl aminopeptidase	Homo sapiens	127-130
8639500-4	1996	In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34.	Aspartic Acid	141-144	arginyl aminopeptidase	Homo sapiens	127-130
8598053-6	1996	To test the functional role of the respective aspartate residue of Skn7/Pos9 protein in oxidative stress, we mutagenized this residue in vitro to alanine, arginine and glutamate.	Aspartic Acid	46-55	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	67-71
8598053-6	1996	To test the functional role of the respective aspartate residue of Skn7/Pos9 protein in oxidative stress, we mutagenized this residue in vitro to alanine, arginine and glutamate.	Aspartic Acid	46-55	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	72-76
8743562-7	1996	The N-terminal amino acid sequence of MTSP-1 was Ile-Val-Gly-Gly-Tyr-Thr-His-Leu-Asp-Asn-Gln-Val-Pro-Tyr.	Aspartic Acid	81-84	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	38-44
8615762-3	1996	PC8 possessed the catalytically important Asp, His, Asn and Ser amino acids, the homo B domain of this family of enzymes and a C-terminal hydrophobic sequence indicative of a transmembrane domain.	Aspartic Acid	42-45	proprotein convertase subtilisin/kexin type 7	Homo sapiens	0-3
8605870-2	1996	CPP32, a cysteine protease, was shown previously to cleave SREBP-1 and SREBP-2 in vitro at an aspartic acid between the basic helix-loop-helix leucine zipper domain and the first trans-membrane domain, liberating a transcriptionally active fragment.	Aspartic Acid	94-107	sterol regulatory element-binding protein 2	Cricetulus griseus	71-78
8605870-8	1996	CHO cells expressing a mutant SREBP-2 with an Asp--&gt; Ala mutation at the CPP32 cleavage site showed sterol-regulated cleavage but no apoptosis-induced cleavage.	Aspartic Acid	46-49	sterol regulatory element-binding protein 2	Cricetulus griseus	30-37
8648190-7	1996	Adhesion to fibronectin and vitronectin was found to be divalent cation- and arginine-glycine-aspartic acid-dependent, and could be blocked by antibodies to beta 1 or alpha 5, and alpha v or alpha v beta 5, respectively.	Aspartic Acid	94-107	fibronectin 1	Homo sapiens	12-23
8901136-6	1996	An asparagine (AAT) to aspartate (GAT) change was found in exon 6 (residue 336) in the IowaUF and NetherlandsUF alleles.	Aspartic Acid	23-32	stress-sensitive B	Drosophila melanogaster	15-18
8901136-6	1996	An asparagine (AAT) to aspartate (GAT) change was found in exon 6 (residue 336) in the IowaUF and NetherlandsUF alleles.	Aspartic Acid	23-32	GABA transporter	Drosophila melanogaster	34-37
8617773-3	1996	Mutation of Asp-72, Asp-92, Tyr-7, Trp-12, and Met-125 resulted in over a 90% activity loss whereas mutation of Tyr-157, Trp-64, and Trp-127 produced less than a 80% activity loss.	Aspartic Acid	12-15	transient receptor potential cation channel subfamily V member 4	Homo sapiens	35-41
8786069-5	1996	The Moslem Arabs were homozygous for two mutations in the GALC gene; a T-to-C transition at CDNA position 1637 (counting from the A of the initiation codon), which is considered a polymorphism and a G-to-A transition at position 1582, which changes the codon for aspartic acid to one for asparagine.	Aspartic Acid	263-276	galactosylceramidase	Homo sapiens	58-62
8675500-1	1996	Keratinocytes and fibroblasts interact with proteins of the extracellular matrix such as fibronectin and vitronectin through RGD (arginine-glycine-aspartic acid) cell-attachment sequences.	Aspartic Acid	147-160	fibronectin 1	Homo sapiens	89-100
8675500-1	1996	Keratinocytes and fibroblasts interact with proteins of the extracellular matrix such as fibronectin and vitronectin through RGD (arginine-glycine-aspartic acid) cell-attachment sequences.	Aspartic Acid	147-160	vitronectin	Homo sapiens	105-116
8642267-5	1996	An aspartic acid located at position 137, which is essential to ICAM-1/LFA-1 interactions (Edwards, C.P., M. Champe, T. Gonzalez, M.E.	Aspartic Acid	3-16	intercellular adhesion molecule 1	Homo sapiens	64-70
8642267-5	1996	An aspartic acid located at position 137, which is essential to ICAM-1/LFA-1 interactions (Edwards, C.P., M. Champe, T. Gonzalez, M.E.	Aspartic Acid	3-16	integrin subunit alpha L	Homo sapiens	71-76
8642268-5	1996	We found that a single Ala--&gt;Asp amino acid 57 substitution in an HLA-DQ3.2 molecule regulated binding of an HSV-2 VP-16-derived peptide.	Aspartic Acid	32-35	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	69-72
8648190-7	1996	Adhesion to fibronectin and vitronectin was found to be divalent cation- and arginine-glycine-aspartic acid-dependent, and could be blocked by antibodies to beta 1 or alpha 5, and alpha v or alpha v beta 5, respectively.	Aspartic Acid	94-107	vitronectin	Homo sapiens	28-39
8721753-9	1996	The aspartate that replaced Ser-534 did not appear to mimic a phosphorylated serine but simply prevented the NR from being inactivated.	Aspartic Acid	4-13	nitrate reductase 1	Arabidopsis thaliana	109-111
8605632-5	1996	The carboxylate of Asp 49 forms hydrogen bonds to four conserved, catalytic residues in the beta-lactamase, thereby mimicking the position of the penicillin G carboxylate observed in the acyl-enzyme complex of TEM-1 with substrate.	Aspartic Acid	19-22	CD248 molecule	Homo sapiens	210-215
8740695-1	1996	One family (ADRP15) was found to have mutation in codon 114 of the rhodopsin gene that led to a substitution of a glycine for an aspartic acid.	Aspartic Acid	129-142	rhodopsin	Homo sapiens	67-76
8622647-7	1996	By contrast, B-Raf has aspartic acid residues at positions homologous to those of the phosphorylated tyrosines (at 340 and 341) of Raf-1 and displays a high basal level of activity.	Aspartic Acid	23-36	Braf transforming gene	Mus musculus	13-18
8635735-4	1996	The C terminus of Ytp1 is both hydrophilic and highly negatively charged, with 11 of the last 33 aa corresponding to Glu or Asp.	Aspartic Acid	124-127	Ytp1p	Saccharomyces cerevisiae S288C	18-22
8645288-0	1996	Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production.	Aspartic Acid	15-24	platelet activating factor receptor	Homo sapiens	53-88
8631931-3	1996	With the exception of rare instances, mutant KITs with substitutions of Asp814 were found to be constitutively phosphorylated on tyrosine and activated in the absence of the ligand, stem cell factor (SCF), whereas a deletion mutant lacking Asp814 (KITDel-Asp-814) did not exhibit tyrosine phosphorylation and activation even after treatment with SCF.	Aspartic Acid	72-75	KIT ligand	Homo sapiens	182-198
8652590-3	1996	The lower axial ligand to the cobalt in free methylcobalamin is the dimethylbenzimidazole nucleotide substituent of the corrin ring; when methylcobalamin binds to methionine synthase, the ligand is replaced by histidine 759, which in turn is linked by hydrogen bonds to aspartate 757 and thence to serine 810.	Aspartic Acid	270-279	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	163-182
8631956-5	1996	Peptide aldehydes with aspartic acid at the P1 position blocked Ced-3 autocatalysis.	Aspartic Acid	23-36	intraflagellar transport 43	Homo sapiens	64-69
8631931-3	1996	With the exception of rare instances, mutant KITs with substitutions of Asp814 were found to be constitutively phosphorylated on tyrosine and activated in the absence of the ligand, stem cell factor (SCF), whereas a deletion mutant lacking Asp814 (KITDel-Asp-814) did not exhibit tyrosine phosphorylation and activation even after treatment with SCF.	Aspartic Acid	72-75	KIT ligand	Homo sapiens	200-203
8631931-3	1996	With the exception of rare instances, mutant KITs with substitutions of Asp814 were found to be constitutively phosphorylated on tyrosine and activated in the absence of the ligand, stem cell factor (SCF), whereas a deletion mutant lacking Asp814 (KITDel-Asp-814) did not exhibit tyrosine phosphorylation and activation even after treatment with SCF.	Aspartic Acid	72-75	KIT ligand	Homo sapiens	346-349
8579377-0	1996	Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.	Aspartic Acid	21-24	cytochrome p450 oxidoreductase	Rattus norvegicus	85-116
8579377-1	1996	Asp-290 of the phenobarbital-inducible dog liver cytochrome P450 (P450) 2B11 was mutated to nine other amino acid residues by site-directed mutagenesis, and the functional significance of the unique negative charge in P450 2B11 at that position was studied.	Aspartic Acid	0-3	Cytochrome P450 1A1	Canis lupus familiaris	49-76
8589252-1	1996	Conformational free energy calculations using an empirical potential ECEPP/3 (Empirical Conformational Energy Program for Peptides, Version 3) were carried out on angiotensin II (AII) of sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe to find the stable conformations of the free state in the unhydrated and the hydrated states.	Aspartic Acid	196-199	angiotensinogen	Homo sapiens	163-177
8589252-1	1996	Conformational free energy calculations using an empirical potential ECEPP/3 (Empirical Conformational Energy Program for Peptides, Version 3) were carried out on angiotensin II (AII) of sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe to find the stable conformations of the free state in the unhydrated and the hydrated states.	Aspartic Acid	196-199	angiotensinogen	Homo sapiens	179-182
8566604-7	1996	This effect of Cbz-Leu-Leu-Tyr-CHN2 was specific because serine, aspartate, and metalloprotease inhibitors did not inhibit the MMPT.	Aspartic Acid	65-74	chimerin 2	Rattus norvegicus	31-35
8598221-1	1996	The hematopoietic cell recognition sites of human fibronectin (FN) are the Arg-Gly-Asp-Ser (RGDS) sequence recognized by widely distributed integrin receptor alpha 5 beta 1 and the type III connecting segment (III CS) containing two cell-binding sites, designated CS1 and CS5, that are recognized by the alpha 4 beta 1 receptor.	Aspartic Acid	83-86	fibronectin 1	Homo sapiens	50-61
8598221-1	1996	The hematopoietic cell recognition sites of human fibronectin (FN) are the Arg-Gly-Asp-Ser (RGDS) sequence recognized by widely distributed integrin receptor alpha 5 beta 1 and the type III connecting segment (III CS) containing two cell-binding sites, designated CS1 and CS5, that are recognized by the alpha 4 beta 1 receptor.	Aspartic Acid	83-86	fibronectin 1	Homo sapiens	63-65
8789092-3	1996	The aspartate residue in the second putative transmembrane segment of the IRK1 inwardly rectifying K+ channel, previously implicated in inward rectification gating due to cytoplasmic Mg2+ and polyamine block, is found in this study to be crucial for the channel"s ability to distinguish between K+ and Rb+ ions.	Aspartic Acid	4-13	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	74-78
8598221-12	1996	The active region of this peptide was a sequence of Thr-Asp-Ile-Asp-Ala-Pro-Ser (TAI-DAPS), which is homologous to Leu-Asp-Val-Pro-Ser (LDVPS) derived from the active site of CS1.	Aspartic Acid	56-59	myozenin 2	Homo sapiens	175-178
8598221-12	1996	The active region of this peptide was a sequence of Thr-Asp-Ile-Asp-Ala-Pro-Ser (TAI-DAPS), which is homologous to Leu-Asp-Val-Pro-Ser (LDVPS) derived from the active site of CS1.	Aspartic Acid	64-67	myozenin 2	Homo sapiens	175-178
8598221-1	1996	The hematopoietic cell recognition sites of human fibronectin (FN) are the Arg-Gly-Asp-Ser (RGDS) sequence recognized by widely distributed integrin receptor alpha 5 beta 1 and the type III connecting segment (III CS) containing two cell-binding sites, designated CS1 and CS5, that are recognized by the alpha 4 beta 1 receptor.	Aspartic Acid	83-86	ral guanine nucleotide dissociation stimulator	Homo sapiens	92-96
8576067-8	1996	Aspartate was identified as the most repressing sole carbon source for alpha-amylase production, while glutamate was the most derepressing.	Aspartic Acid	0-9	glycoside hydrolase family 57 protein	Saccharolobus solfataricus	71-84
8777952-5	1996	Evaluation of HLA class II gene products in TDI-induced asthma cases showed a positive association with HLA-DQB1 * 0503 and a negative association with HLA-DQB1 * 0501 alleles, which differed at residue 57 for a single amino acid, i.e. aspartic acid in DQB1 * 0503 and valine in DQB1 * 0501.	Aspartic Acid	236-249	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	14-17
8636646-5	1996	Interestingly, when Gln and Asn located at positions 15 and 24, respectively, of the PF4 C-terminal region were replaced by Glu and Asp (C13-24DE), an increase in the inhibitory activity was observed.	Aspartic Acid	132-135	platelet factor 4	Homo sapiens	85-88
8636223-1	1996	Integrin alpha v beta 3 is distinct in its capacity to recognize the sequence Arg-Gly-Asp (RGD) in many extra-cellular matrix (ECM) components.	Aspartic Acid	86-89	integrin subunit alpha V	Homo sapiens	0-23
8557989-6	1996	A specific epitope could be mapped with IL-8R beta mutants to the peptide sequence between ASP-4 and ASP-14 of this receptor.	Aspartic Acid	91-94	C-X-C motif chemokine receptor 2	Homo sapiens	40-50
9173910-9	1996	A beta peptides starting at aspartate 1 or pyroglutamate 3 were detected in small subsets of compacted, neuritic plaques beginning around age 30 and rose with age, the latter species always exceeding the former.	Aspartic Acid	28-37	amyloid beta precursor protein	Homo sapiens	0-6
8551601-2	1996	Sequence analysis of viral DNA derived from long-term cultures of Jurkat cells revealed a specific mutation that changed a highly conserved Asn residue in the V1 loop of Env to an Asp residue (N-136--&gt;D).	Aspartic Acid	180-183	endogenous retrovirus group W member 1, envelope	Homo sapiens	170-173
8683463-9	1996	An acidic residue (aspartate) in TM2 partially controls the time- and voltage-dependent gating in IRK1 (KIR2.1).	Aspartic Acid	19-28	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	98-102
8683463-9	1996	An acidic residue (aspartate) in TM2 partially controls the time- and voltage-dependent gating in IRK1 (KIR2.1).	Aspartic Acid	19-28	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	104-110
8649438-5	1996	The peptide, which incorporates three gp120 residues Asp 368, Glu 370 and Asp 457, previously shown to be critical for CD4 ligation, bound to the surface of a CD4 transfected human epithelial cell line HeLa, but not to the parent cell line and inhibited binding of recombinant HIV-1 gp120 to recombinant soluble CD4.	Aspartic Acid	53-56	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	38-43
8649438-5	1996	The peptide, which incorporates three gp120 residues Asp 368, Glu 370 and Asp 457, previously shown to be critical for CD4 ligation, bound to the surface of a CD4 transfected human epithelial cell line HeLa, but not to the parent cell line and inhibited binding of recombinant HIV-1 gp120 to recombinant soluble CD4.	Aspartic Acid	53-56	CD4 molecule	Homo sapiens	159-162
8649438-5	1996	The peptide, which incorporates three gp120 residues Asp 368, Glu 370 and Asp 457, previously shown to be critical for CD4 ligation, bound to the surface of a CD4 transfected human epithelial cell line HeLa, but not to the parent cell line and inhibited binding of recombinant HIV-1 gp120 to recombinant soluble CD4.	Aspartic Acid	53-56	CD4 molecule	Homo sapiens	159-162
8649438-5	1996	The peptide, which incorporates three gp120 residues Asp 368, Glu 370 and Asp 457, previously shown to be critical for CD4 ligation, bound to the surface of a CD4 transfected human epithelial cell line HeLa, but not to the parent cell line and inhibited binding of recombinant HIV-1 gp120 to recombinant soluble CD4.	Aspartic Acid	74-77	CD4 molecule	Homo sapiens	119-122
8649438-5	1996	The peptide, which incorporates three gp120 residues Asp 368, Glu 370 and Asp 457, previously shown to be critical for CD4 ligation, bound to the surface of a CD4 transfected human epithelial cell line HeLa, but not to the parent cell line and inhibited binding of recombinant HIV-1 gp120 to recombinant soluble CD4.	Aspartic Acid	74-77	CD4 molecule	Homo sapiens	159-162
8649438-5	1996	The peptide, which incorporates three gp120 residues Asp 368, Glu 370 and Asp 457, previously shown to be critical for CD4 ligation, bound to the surface of a CD4 transfected human epithelial cell line HeLa, but not to the parent cell line and inhibited binding of recombinant HIV-1 gp120 to recombinant soluble CD4.	Aspartic Acid	74-77	CD4 molecule	Homo sapiens	159-162
8567622-3	1996	CMH-1 shares conserved amino acid residues that form the core structure of ICE as well as those residues involved in catalysis and in the P1 aspartate binding.	Aspartic Acid	141-150	caspase 7	Homo sapiens	0-5
8579602-0	1996	Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin.	Aspartic Acid	118-121	secretin receptor	Rattus norvegicus	51-68
8579602-7	1996	As an aspartate is also present in position 3 of VIP and PACAP, two peptides related to secretin, and a lysine residue is conserved in the first extracellular loop of the VIP and PACAP receptors, this interaction may be a key element of peptide recognition by this receptor family.	Aspartic Acid	6-15	vasoactive intestinal peptide	Rattus norvegicus	49-52
8579602-7	1996	As an aspartate is also present in position 3 of VIP and PACAP, two peptides related to secretin, and a lysine residue is conserved in the first extracellular loop of the VIP and PACAP receptors, this interaction may be a key element of peptide recognition by this receptor family.	Aspartic Acid	6-15	adenylate cyclase activating polypeptide 1	Rattus norvegicus	57-62
8579602-7	1996	As an aspartate is also present in position 3 of VIP and PACAP, two peptides related to secretin, and a lysine residue is conserved in the first extracellular loop of the VIP and PACAP receptors, this interaction may be a key element of peptide recognition by this receptor family.	Aspartic Acid	6-15	vasoactive intestinal peptide	Rattus norvegicus	171-174
8579602-7	1996	As an aspartate is also present in position 3 of VIP and PACAP, two peptides related to secretin, and a lysine residue is conserved in the first extracellular loop of the VIP and PACAP receptors, this interaction may be a key element of peptide recognition by this receptor family.	Aspartic Acid	6-15	adenylate cyclase activating polypeptide 1	Rattus norvegicus	179-184
8851732-0	1996	Identification of DRB1 allele (DRB1*1316) with aspartate at position 86: evolutionary considerations and functional implications.	Aspartic Acid	47-56	major histocompatibility complex, class II, DR beta 1	Homo sapiens	18-22
8851732-0	1996	Identification of DRB1 allele (DRB1*1316) with aspartate at position 86: evolutionary considerations and functional implications.	Aspartic Acid	47-56	major histocompatibility complex, class II, DR beta 1	Homo sapiens	31-35
8675133-3	1996	Evaluation of these initial data on in vivo racemization of aspartic acid in bone osteocalcin was taken a step further.	Aspartic Acid	60-73	bone gamma-carboxyglutamate protein	Homo sapiens	82-93
8561787-1	1996	Glycosylasparaginase (EC 3.5.1.26) is an amidase, which cleaves the N-glycosidic linkage during glycoprotein degradation leading to the liberation of L-aspartic acid from various glycoasparagines.	Aspartic Acid	150-165	aspartylglucosaminidase	Homo sapiens	0-20
8845469-2	1996	A heterozygous mutation in the factor VII gene exon 8 was identified as substitution of A for G at nucleotide position 10,909 [Gly331(GGC) to Asp (GAC)].	Aspartic Acid	142-145	gamma-glutamylcyclotransferase	Homo sapiens	134-137
8538770-5	1996	The histidine at position 1,106(aspartic acid in C4A) first attacks the thioester to form an acyl-imidazole intermediate.	Aspartic Acid	32-45	complement C4A (Rodgers blood group)	Homo sapiens	49-52
8555200-1	1996	The pH dependence of the 13C chemical shifts of the side-chain carboxyl carbons of all Asp and Glu residues in the reduced and oxidized states of human thioredoxin and in a mixed disulfide complex of human thioredoxin with a target peptide from the transcription factor NF kappa B has been investigated by multidimensional triple-resonance NMR spectroscopy.	Aspartic Acid	87-90	thioredoxin	Homo sapiens	152-163
8555200-1	1996	The pH dependence of the 13C chemical shifts of the side-chain carboxyl carbons of all Asp and Glu residues in the reduced and oxidized states of human thioredoxin and in a mixed disulfide complex of human thioredoxin with a target peptide from the transcription factor NF kappa B has been investigated by multidimensional triple-resonance NMR spectroscopy.	Aspartic Acid	87-90	thioredoxin	Homo sapiens	206-217
8805511-8	1996	The aspartate residue, which would come into unacceptably close contact with the 2"-phosphate group of the adenosine moiety of NADPH, is replaced by a threonine or alanine in the primary sequences of NADPH-preferring enzymes of the SDR family.	Aspartic Acid	4-13	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	127-132
8805511-8	1996	The aspartate residue, which would come into unacceptably close contact with the 2"-phosphate group of the adenosine moiety of NADPH, is replaced by a threonine or alanine in the primary sequences of NADPH-preferring enzymes of the SDR family.	Aspartic Acid	4-13	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	200-205
8624397-1	1996	This in vitro study was an investigation of osteoblast functions on glass substrates modified with the bioactive peptide Arg-Gly-Asp-Ser (RGDS) in the absence and presence of recombinant human Osteogenic Protein-1 (OP-1); control substrates were plain glass, glass modified with amine groups, and glass modified with the non-adhesive peptide Arg-Asp-Gly-Ser.	Aspartic Acid	129-132	ral guanine nucleotide dissociation stimulator	Homo sapiens	138-142
8547652-3	1996	Sequencing of the whole coding region of the c-kit showed that the point mutation found in HMC-1, P-815, and RBL-2H3 cells was absent in FMA3 cells and that the c-kit cDNA of FMA3 cells carried an in-frame deletion of 21 base pairs (bp) encoding Thr-Gln-Leu-Pro-Tyr-Asp-His at codons 573 to 579 at the juxtamembrane domain.	Aspartic Acid	266-269	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	45-50
8547652-3	1996	Sequencing of the whole coding region of the c-kit showed that the point mutation found in HMC-1, P-815, and RBL-2H3 cells was absent in FMA3 cells and that the c-kit cDNA of FMA3 cells carried an in-frame deletion of 21 base pairs (bp) encoding Thr-Gln-Leu-Pro-Tyr-Asp-His at codons 573 to 579 at the juxtamembrane domain.	Aspartic Acid	266-269	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	161-166
17180049-3	1996	P35 has recently been shown to be capable of inhibiting the ICE/ced-3 family of cysteine proteases, a family of enzymes which are implicated in cell death and which exhibit specificity for cleavage at aspartate residues.	Aspartic Acid	201-210	interleukin 12A	Homo sapiens	0-3
8993775-5	1996	Amino acid analysis indicates that LSF is a peptide composed of Asp, Glu, Ser, Thr, Ala, Gly, Arg and probably Met, with the N-terminus blocked, possibly by pyroglutamic acid.	Aspartic Acid	64-67	transcription factor CP2	Mus musculus	35-38
8565226-1	1996	Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH.	Aspartic Acid	154-157	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-127
8565226-1	1996	Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH.	Aspartic Acid	154-157	acetylcholinesterase (Cartwright blood group)	Homo sapiens	129-133
9084652-1	1996	Osteopontin is a multiply-phosphorylated glycoprotein which contains an RGD cell adhesion sequence and regions containing a high level of aspartic acid.	Aspartic Acid	138-151	secreted phosphoprotein 1	Rattus norvegicus	0-11
8565226-1	1996	Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH.	Aspartic Acid	170-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-127
8565226-1	1996	Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH.	Aspartic Acid	170-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	129-133
8981016-3	1996	In the cognate variant TR beta (TR beta-CN) amino acid codon 322 was exchanged from aspartic acid to asparagine.	Aspartic Acid	84-97	T cell receptor beta locus	Homo sapiens	23-30
8981016-3	1996	In the cognate variant TR beta (TR beta-CN) amino acid codon 322 was exchanged from aspartic acid to asparagine.	Aspartic Acid	84-97	T cell receptor beta locus	Homo sapiens	32-39
8979267-1	1996	The partially modified retro- and retro-inverso peptides of the Arg-Gly Asp (RGD) sequence of fibronectin, in which the direction of the Arg residue is reversed and/or the chirality of the amino acid residue is inverted, i.e., mainly R(rev)-COCH2CO-D and DR(rev)-COCH2CO-D, have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as their inhibitory effect on tumor cell invasion in vitro.	Aspartic Acid	72-75	fibronectin 1	Mus musculus	94-105
8550313-13	1996	Cell adhesion to fibronectin and vitronectin was inhibited by peptides containing the Arg-Gly-Asp sequence.	Aspartic Acid	94-97	fibronectin 1	Homo sapiens	17-28
8550313-13	1996	Cell adhesion to fibronectin and vitronectin was inhibited by peptides containing the Arg-Gly-Asp sequence.	Aspartic Acid	94-97	vitronectin	Homo sapiens	33-44
8523543-7	1996	A similar analysis of proteins substituted at position 237 revealed that aspartic acid, but not arginine or lysine, can functionally substitute for glutamic acid 237 in ATRC1 or at the corresponding position in the human protein.	Aspartic Acid	73-86	solute carrier family 7 member 1	Homo sapiens	169-174
8825870-4	1996	The histidine B10 to aspartic acid mutation creates a more stable form of insulin leading to an increase in insulin accumulation.	Aspartic Acid	21-34	insulin	Homo sapiens	74-81
10608036-1	1996	Arg-Gly-Asp (RGD)-containing peptides and the peptide unique to fibrinogen in the C-terminal domain of the gamma chain are important for fibrinogen binding to platelet membrane glycoprotein (GP) II b/III a.	Aspartic Acid	8-11	fibrinogen beta chain	Homo sapiens	137-147
8771191-3	1996	Herein we identify aspartic acid 383 as a potential candidate for the catalytic acid in human Cdc25A protein phosphatase, using sequence alignment, structural information, and site-directed mutagenesis.	Aspartic Acid	19-32	cell division cycle 25A	Homo sapiens	94-100
8530505-8	1995	These results were consistent with the loss of a slow cGMP-binding site in repeat a of the D289A mutant cGB-PDE, and the loss of a fast site in repeat b of the D478A mutant, suggesting that cGB-PDE possesses two distinct cGMP-binding sites located at repeats a and b, with the invariant aspartic acid being crucial for interaction with cGMP at each site.	Aspartic Acid	287-300	phosphodiesterase 5A	Bos taurus	190-197
8865363-4	1996	The cycle is driven by a ligand-mediated proton pump through the alpha-helices of the receptor, attachment of the conserved Tyr-Arg-Tyr receptor proton shuttle being made to an aspartate group on the Gs alpha-protein terminal sidechain, which is itself linked to the Asn-Gln interaction known to control movement and rotation of the alpha 2-helix between .GDP and .GTP structures.	Aspartic Acid	177-186	GNAS complex locus	Homo sapiens	200-208
12232603-1	1996	B9Ser and B10His of the insulin B chain are substituted respectively by Glu and Asp using a gapped duplex DNA approach for site-directed mutagenesis.	Aspartic Acid	80-83	insulin	Homo sapiens	24-31
12232617-4	1996	Since PHO2 Asp-230 mutant mimics Ser-230 phosphorylated PHO2, we postulate that only phosphorylated PHO2 protein could activate the transcription of the PHO5 gene.	Aspartic Acid	11-14	Pho2p	Saccharomyces cerevisiae S288C	6-10
12232617-4	1996	Since PHO2 Asp-230 mutant mimics Ser-230 phosphorylated PHO2, we postulate that only phosphorylated PHO2 protein could activate the transcription of the PHO5 gene.	Aspartic Acid	11-14	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	153-157
8557034-7	1995	Moreover, cleavage of PKC delta occurs adjacent to aspartic acid at a site (QDN) similar to that involved in proteolytic activation of interleukin-1 beta converting enzyme (ICE).	Aspartic Acid	51-64	protein kinase C delta	Homo sapiens	22-31
8719338-2	1995	However, by the use of a bilateral in situ brain perfusion in neonatal and adult rats, extending the perfusion time to 30 min, the carrier-mediated uptake of aspartate and glutamate into brain and CSF has been demonstrated.	Aspartic Acid	158-167	colony stimulating factor 2	Rattus norvegicus	197-200
8719338-6	1995	In general the Kin values for brain and CSF for aspartate and glutamate were higher in the younger age groups than the adult group (1 week &gt; 2 week &gt; 3 week &gt; or = adult).	Aspartic Acid	48-57	Kin17 DNA and RNA binding protein	Rattus norvegicus	15-18
8719338-6	1995	In general the Kin values for brain and CSF for aspartate and glutamate were higher in the younger age groups than the adult group (1 week &gt; 2 week &gt; 3 week &gt; or = adult).	Aspartic Acid	48-57	colony stimulating factor 2	Rattus norvegicus	40-43
8530370-8	1995	We therefore constructed Fc alpha R molecules where Arg209 was mutated to either a positively charged histidine, a negatively charged aspartic acid, or an uncharged leucine.	Aspartic Acid	134-147	Fc alpha receptor	Homo sapiens	25-35
8825075-2	1995	Several recent studies have linked a previously reported substitution, N314D (asn to asp at position 314), with both the Duarte and Los Angeles (LA) variant alleles of GALT.	Aspartic Acid	85-88	galactose-1-phosphate uridylyltransferase	Homo sapiens	168-172
8519750-0	1995	Structure-function analysis of the mammalian DNA polymerase beta active site: role of aspartic acid 256, arginine 254, and arginine 258 in nucleotidyl transfer.	Aspartic Acid	86-99	DNA polymerase beta	Homo sapiens	45-64
7492289-7	1995	However, we did identify an amino acid substitution (glycine to aspartic acid) in exon 9 of the catalase gene in one patient; decreased red blood cell catalase activity was observed in this patient.	Aspartic Acid	64-77	catalase	Homo sapiens	96-104
7492289-7	1995	However, we did identify an amino acid substitution (glycine to aspartic acid) in exon 9 of the catalase gene in one patient; decreased red blood cell catalase activity was observed in this patient.	Aspartic Acid	64-77	catalase	Homo sapiens	151-159
8635999-1	1995	We examined whether the novel point mutation from GCC (Ala) to GAC (Asp) at codon 664 in exon 11 of RET proto-oncogene, which we had found in two small cell lung carcinoma (SCLC) cell lines, existed in genomic DNA of tumor tissues of the two SCLC patients from whom these SCLC cell lines were derived.	Aspartic Acid	68-71	guanylate cyclase 2C	Homo sapiens	50-53
8635999-1	1995	We examined whether the novel point mutation from GCC (Ala) to GAC (Asp) at codon 664 in exon 11 of RET proto-oncogene, which we had found in two small cell lung carcinoma (SCLC) cell lines, existed in genomic DNA of tumor tissues of the two SCLC patients from whom these SCLC cell lines were derived.	Aspartic Acid	68-71	ret proto-oncogene	Homo sapiens	100-103
8614409-2	1995	We examined the analogous region in the rat follitropin receptor (rFSHR) by substituting the Asp at position 404 (D404) of the rFSHR with either Glu (D404E), Ala (D404A), or Lys (D404K).	Aspartic Acid	93-96	follicle stimulating hormone receptor	Rattus norvegicus	66-71
8747924-3	1995	In Gpi1-sam1H amino acid residue 277, TCA Ser (wild type), is altered to CCA Pro, and in Gpi1-sbm3H and Gpi1-sbm4H amino acid residue 510 Asp GAC (wild type) is altered to GGC Gly.	Aspartic Acid	138-141	glucose-6-phosphate isomerase 1	Mus musculus	89-93
8747924-3	1995	In Gpi1-sam1H amino acid residue 277, TCA Ser (wild type), is altered to CCA Pro, and in Gpi1-sbm3H and Gpi1-sbm4H amino acid residue 510 Asp GAC (wild type) is altered to GGC Gly.	Aspartic Acid	138-141	glucose-6-phosphate isomerase 1	Mus musculus	89-93
8526238-6	1995	CSF aspartate concentrations were significantly elevated in patients with tardive dyskinesia when medication status was controlled for and were significantly correlated with total scores on the AIMS.	Aspartic Acid	4-13	colony stimulating factor 2	Homo sapiens	0-3
8825099-2	1995	This class of bacterial sensory kinases, typified by ArcB and BarA, possesses two phospho-donor (His) sites, together with a phospho-accepting (Asp) site.	Aspartic Acid	144-147	hypothetical protein	Escherichia coli	53-57
8825099-2	1995	This class of bacterial sensory kinases, typified by ArcB and BarA, possesses two phospho-donor (His) sites, together with a phospho-accepting (Asp) site.	Aspartic Acid	144-147	lin-9 DREAM MuvB core complex component	Homo sapiens	62-66
7592955-7	1995	However, nodulin 26 with Asp-262 showed increased gating and preferential occupancy of lower subconductance states (1.8 and 0.6 nS in cis0.2M/trans1.0 M KCl) at high applied voltages (e.g. 70 mV).	Aspartic Acid	25-28	nodulin-26	Glycine max	9-19
8789612-2	1995	Comparing the quantitative distributions among regions revealed significant correlations between AAT and aspartate, between glutaminase and glutamate, between glutamate and glutamine, and between AAT plus glutaminase, or glutaminase alone, and the sum of aspartate, glutamate, and GABA, suggesting a metabolic pathway involving the synthesis of a glutamate pool as precursor to aspartate and GABA.	Aspartic Acid	105-114	serpin family A member 1	Rattus norvegicus	97-100
8524660-6	1995	The latter was replicated in vitro and used as a mutagenic cassette to produce four mutants of Asp 221 in the enzyme thymidylate synthase.	Aspartic Acid	95-98	thymidylate synthetase	Homo sapiens	117-137
7592904-4	1995	A single mocarhagin cleavage site between Tyr-10 and Asp-11 of mature PSGL-1 was determined by N-terminal sequencing of mocarhagin fragments of sPSGL-1.T7 and is within a highly negatively charged amino acid sequence 1-QATEYEYLDY decreases DFLPETEPPE, containing three tyrosine residues that are consensus sulfation sites.	Aspartic Acid	53-56	selectin P ligand	Homo sapiens	70-76
8618801-2	1995	Sequencing of the GH releasing hormone (GHRH) receptor in lit/lit mice has shown a single nucleotide substitution within the extracellular peptide binding domain at codon 60 that changed aspartic acid to glycine.	Aspartic Acid	187-200	growth hormone releasing hormone	Homo sapiens	40-44
7488212-0	1995	Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2.	Aspartic Acid	29-38	somatostatin receptor 2	Rattus norvegicus	148-153
7592904-5	1995	Consistent with a functional role of this region of PSGL-1 in binding P-selectin, an affinity-purified polyclonal antibody against residues Gln-1-Glu-15 of PSGL-1 strongly inhibited P-selectin binding to neutrophils, whereas an antibody against residues Asp-9-Arg-23 was noninhibitory.	Aspartic Acid	254-257	selectin P ligand	Homo sapiens	52-58
7592904-5	1995	Consistent with a functional role of this region of PSGL-1 in binding P-selectin, an affinity-purified polyclonal antibody against residues Gln-1-Glu-15 of PSGL-1 strongly inhibited P-selectin binding to neutrophils, whereas an antibody against residues Asp-9-Arg-23 was noninhibitory.	Aspartic Acid	254-257	selectin P	Homo sapiens	70-80
7592904-5	1995	Consistent with a functional role of this region of PSGL-1 in binding P-selectin, an affinity-purified polyclonal antibody against residues Gln-1-Glu-15 of PSGL-1 strongly inhibited P-selectin binding to neutrophils, whereas an antibody against residues Asp-9-Arg-23 was noninhibitory.	Aspartic Acid	254-257	selectin P ligand	Homo sapiens	156-162
7592904-5	1995	Consistent with a functional role of this region of PSGL-1 in binding P-selectin, an affinity-purified polyclonal antibody against residues Gln-1-Glu-15 of PSGL-1 strongly inhibited P-selectin binding to neutrophils, whereas an antibody against residues Asp-9-Arg-23 was noninhibitory.	Aspartic Acid	254-257	selectin P	Homo sapiens	182-192
8624506-4	1995	In addition a more active malate-aspartate shuttle, which in heart provides the major route for transfer of reducing equivalents to the mitochondria, was suggested by elevated levels of the cytosolic isoenzyme of aspartate aminotransferase; malate dehydrogenase did not increase but the activity of this enzyme is very high and unlikely to be rate-limiting in the shuttle.	Aspartic Acid	33-42	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	213-239
7487919-0	1995	The Gly-54--&gt;Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease.	Aspartic Acid	16-19	myelin basic protein	Homo sapiens	42-65
7487919-0	1995	The Gly-54--&gt;Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease.	Aspartic Acid	16-19	myelin basic protein	Homo sapiens	67-70
7487919-5	1995	A homozygous mutation at base pair 230 of the MBP gene results in a Gly-to-Asp substitution at the fifth collagen repeat.	Aspartic Acid	75-78	myelin basic protein	Homo sapiens	46-49
7487919-11	1995	Our results provide a biochemical basis for the functional deficit in the Gly-54--&gt;Asp allelic form of MBP and suggest that the proMASP/MASP binding site maps to the fifth collagen repeat of MBP.	Aspartic Acid	86-89	myelin basic protein	Homo sapiens	106-109
8521863-4	1995	It copurified with the brain-specific Na(+)-dependent high-affinity L-glutamate/aspartate neurotransmitter transporter (GLAST-1) of the central nervous system.	Aspartic Acid	80-89	solute carrier family 1 member 3	Rattus norvegicus	120-127
7489707-7	1995	Moreover, by using in vitro mutagenesis, we also demonstrate that the proteolytic processing of Gas2 during apoptosis is dependent on an aspartic acid residue at position 279.	Aspartic Acid	137-150	growth arrest specific 2	Mus musculus	96-100
7576180-0	1995	Aspartic acid residue 124 in the third transmembrane domain of the somatostatin receptor subtype 3 is essential for somatostatin-14 binding.	Aspartic Acid	0-13	somatostatin receptor 3	Rattus norvegicus	67-98
7576180-3	1995	To test whether Asp-124 of the rat somatostatin receptor subtype 3 (SSTR3) is responsible for the binding of somatostain-14 (SST-14), this amino acid residue was replaced by an asparagine or a glutamic acid by polymerase chain reaction (PCR)-mediated site-directed mutagenesis.	Aspartic Acid	16-19	somatostatin receptor 3	Rattus norvegicus	35-66
7576180-3	1995	To test whether Asp-124 of the rat somatostatin receptor subtype 3 (SSTR3) is responsible for the binding of somatostain-14 (SST-14), this amino acid residue was replaced by an asparagine or a glutamic acid by polymerase chain reaction (PCR)-mediated site-directed mutagenesis.	Aspartic Acid	16-19	somatostatin receptor 3	Rattus norvegicus	68-73
7576655-5	1995	Systematic alterations of side-chain length, charge, and polarity by glutamate replacement with aspartate, glutamine, or alanine weakened the Ca2+ interaction, with considerable asymmetry from one repeat to another.	Aspartic Acid	96-105	carbonic anhydrase 2	Homo sapiens	142-145
7595227-2	1995	The aspartic acid located at position 227 (D227) in the COOH terminus of SEA is one of the three residues involved in its interaction with the DR beta chain, whereas the phenylalanine 47 (F47) of the NH2 terminus is critical for its binding to the DR alpha chain.	Aspartic Acid	4-17	solute carrier family 26 member 3	Homo sapiens	248-256
7489765-6	1995	HLA-B*2709 differs from the most frequent and disease-associated HLA-B*2705 allele for a single substitution (His vs. Asp) at position 116.	Aspartic Acid	118-121	major histocompatibility complex, class I, B	Homo sapiens	0-5
7489765-6	1995	HLA-B*2709 differs from the most frequent and disease-associated HLA-B*2705 allele for a single substitution (His vs. Asp) at position 116.	Aspartic Acid	118-121	major histocompatibility complex, class I, B	Homo sapiens	65-70
8544395-3	1995	The other modifications in beta 2m from amyloid deposits are partial proteolysis and single amino acid replacement (Asn by ASp at position 17).	Aspartic Acid	123-126	beta-2-microglobulin	Homo sapiens	27-34
7588633-5	1995	This stabilization of c-Fos required Mos-induced phosphorylation of its C-terminal region on Ser362 and Ser374, and double replacements of these serines with acidic (Asp) residues markedly increased the stability and transforming efficiency of c-Fos even in the absence of Mos.	Aspartic Acid	166-169	FBJ osteosarcoma oncogene	Mus musculus	22-27
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Aspartic Acid	138-151	cerebellar degeneration related protein 2	Homo sapiens	65-69
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Aspartic Acid	138-151	cerebellar degeneration related protein 1	Homo sapiens	70-74
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Aspartic Acid	138-151	cerebellar degeneration related protein 2	Homo sapiens	162-166
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Aspartic Acid	138-151	CDR3	Homo sapiens	219-223
7479068-5	1995	The epitope recognized by mAb U1 70K was previously shown to be a repeating arginine/aspartate (RD) dipeptide.	Aspartic Acid	85-94	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	30-36
7479069-9	1995	Mutations at three sites, histidine 126, aspartic acid 128 and aspartic acid 130, that are conserved in a subfamily of the plasmid mobilization proteins, led to the loss of VirD2 activity.	Aspartic Acid	41-54	type IV secretion system T-DNA border endonuclease VirD2	Agrobacterium tumefaciens	173-178
7479069-9	1995	Mutations at three sites, histidine 126, aspartic acid 128 and aspartic acid 130, that are conserved in a subfamily of the plasmid mobilization proteins, led to the loss of VirD2 activity.	Aspartic Acid	63-76	type IV secretion system T-DNA border endonuclease VirD2	Agrobacterium tumefaciens	173-178
7492588-1	1995	Isoaspartyl protein carboxyl methyltransferase (PIMT) is implicated in the repair of age-damaged proteins by converting altered aspartic acid residues to normal L-aspartic acid residues.	Aspartic Acid	128-141	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	12-46
7492588-1	1995	Isoaspartyl protein carboxyl methyltransferase (PIMT) is implicated in the repair of age-damaged proteins by converting altered aspartic acid residues to normal L-aspartic acid residues.	Aspartic Acid	128-141	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	48-52
7492588-1	1995	Isoaspartyl protein carboxyl methyltransferase (PIMT) is implicated in the repair of age-damaged proteins by converting altered aspartic acid residues to normal L-aspartic acid residues.	Aspartic Acid	161-176	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	12-46
7492588-1	1995	Isoaspartyl protein carboxyl methyltransferase (PIMT) is implicated in the repair of age-damaged proteins by converting altered aspartic acid residues to normal L-aspartic acid residues.	Aspartic Acid	161-176	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	48-52
7473721-6	1995	Our results indicate that heavy-chain framework residues alanine at H71 and lysine at H93 of the chimeric B72.3 antibody are the major determinants of the conformation of heavy-chain CDR2/CDR1 and CDR3 loops, whereas the salt-bridge between lysine at H73 and aspartic acid at H55 is less important.	Aspartic Acid	259-272	cerebellar degeneration related protein 2	Homo sapiens	183-187
7473721-6	1995	Our results indicate that heavy-chain framework residues alanine at H71 and lysine at H93 of the chimeric B72.3 antibody are the major determinants of the conformation of heavy-chain CDR2/CDR1 and CDR3 loops, whereas the salt-bridge between lysine at H73 and aspartic acid at H55 is less important.	Aspartic Acid	259-272	CDR3	Homo sapiens	197-201
7577910-6	1995	The interaction is observed only when the glutamine residue is N-terminal to the aspartate and when the spacing is (i, i + 4).	Aspartic Acid	81-90	PPP1R2C family member C	Homo sapiens	119-124
7577910-7	1995	The same stereochemistry is found in protein structures, where the (i, i + 4) glutamine-aspartate interaction occurs much more frequently than other possible arrangements.	Aspartic Acid	88-97	PPP1R2C family member C	Homo sapiens	71-76
7588633-5	1995	This stabilization of c-Fos required Mos-induced phosphorylation of its C-terminal region on Ser362 and Ser374, and double replacements of these serines with acidic (Asp) residues markedly increased the stability and transforming efficiency of c-Fos even in the absence of Mos.	Aspartic Acid	166-169	Moloney sarcoma oncogene	Mus musculus	37-40
7559482-9	1995	Examination of additional IL-8-based mutants in the colony formation assay, which centered on the perturbation of the amino-terminal "ELR" motif, resulted in the observation that the highly active IL-8 mutant required both aspartic acid at amino acid residue 4 and either glutamine or asparagine at residue 6.	Aspartic Acid	223-236	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
7579416-5	1995	338Gly--&gt;Asp of the murine R-PK.	Aspartic Acid	12-15	pyruvate kinase liver and red blood cell	Mus musculus	30-34
7559505-3	1995	Recent investigations of the molecular basis of the unusually high enzymatic activity of single-chain t-PA have focused attention upon Asp-194, a residue that is invariant among chymotrypsin-like enzymes.	Aspartic Acid	135-138	plasminogen activator, tissue type	Homo sapiens	102-106
7559487-6	1995	Replacing the phosphorylation sites with alanine residues had a similar effect, while substitution with aspartate, glutamate, or lysine residues produced pleckstrin variants that were fully active even in the absence of phosphorylation.	Aspartic Acid	104-113	pleckstrin	Homo sapiens	154-164
7559505-6	1995	While Asp-194 forms interactions that suppress the activity of the zymogen chymotrypsinogen, it may, by contrast, directly promote the catalytically active conformation of single-chain t-PA.	Aspartic Acid	6-9	plasminogen activator, tissue type	Homo sapiens	185-189
8557169-3	1995	The proprotein convertases are all dependent on calcium for activity and all possess highly conserved subtilisin-like domains with the characteristic catalytic triad of this serine protease (ordered Asp, His, and Ser along the polypeptide chain).	Aspartic Acid	199-202	coagulation factor II, thrombin	Homo sapiens	174-189
7554111-0	1995	Osteopontin and beta 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro.	Aspartic Acid	117-120	secreted phosphoprotein 1	Rattus norvegicus	0-11
7554111-1	1995	Osteopontin is an Arg-Gly-Asp (RGD)-containing acidic glycoprotein postulated to mediate cellular adhesion and migration in a growing number of normal and pathological conditions through interaction with integrin molecules.	Aspartic Acid	26-29	secreted phosphoprotein 1	Rattus norvegicus	0-11
7557090-4	1995	METHODS: Site-directed mutagenesis of a full-length rat LPH complementary DNA was used to convert the rat homologues E1274 and E1750 to aspartic acid or glycine.	Aspartic Acid	136-149	lactase	Rattus norvegicus	56-59
8647397-8	1995	In sca(UM2), an invariant Asp residue is replaced by Asn.	Aspartic Acid	26-29	scabrous	Drosophila melanogaster	3-6
7561880-5	1995	NMDA, aspartate, and high-K+ conditions also induced a cyclic AMP increase; however, a decreasing phase did not follow.	Aspartic Acid	6-15	transmembrane serine protease 5	Rattus norvegicus	62-65
8576092-8	1995	A serine residue reactive with diisopropyl fluorophosphate (DFP) was also identified as Ser587 by preparation of the AARE labeled with tritiated DFP followed by isolation and sequence analysis of a radioactive peptide obtained from its endoproteinase Asp-N digest.	Aspartic Acid	251-254	acylaminoacyl-peptide hydrolase	Homo sapiens	117-121
7565714-5	1995	p68 was shown to contain two Arg-containing Asp-99-dependent binding sites and one Asp-99-independent binding site which lacks an Arg.	Aspartic Acid	44-47	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-3
8562067-7	1995	Amino acid analysis, Edman degradation, and FAB-MS identified T11 as the N-blocked decapeptide pyro-Gln-Pro-Val-Trp-Gln-Asp-Glu-Gly-Gln-Arg derived from the N-terminus of pZPC.	Aspartic Acid	120-123	FA complementation group B	Homo sapiens	44-47
8562067-7	1995	Amino acid analysis, Edman degradation, and FAB-MS identified T11 as the N-blocked decapeptide pyro-Gln-Pro-Val-Trp-Gln-Asp-Glu-Gly-Gln-Arg derived from the N-terminus of pZPC.	Aspartic Acid	120-123	CD2 molecule	Homo sapiens	62-65
8561849-12	1995	The His-400 and Asp-433 residues are conserved in all members of the MMP family.	Aspartic Acid	16-19	matrix metallopeptidase 1	Homo sapiens	69-72
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Aspartic Acid	343-346	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-30
7565714-5	1995	p68 was shown to contain two Arg-containing Asp-99-dependent binding sites and one Asp-99-independent binding site which lacks an Arg.	Aspartic Acid	83-86	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-3
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Aspartic Acid	343-346	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Aspartic Acid	343-346	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
7565714-7	1995	These results indicate that Asp-99 is important for Src SH3 binding specificity and that Asp-99-dependent binding interactions play a dominant role in Src SH3 recognition of cellular binding proteins, and they suggest the existence of two Src SH3 binding mechanisms, one requiring Asp-99 and the other independent of this residue.	Aspartic Acid	28-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	52-55
7565714-7	1995	These results indicate that Asp-99 is important for Src SH3 binding specificity and that Asp-99-dependent binding interactions play a dominant role in Src SH3 recognition of cellular binding proteins, and they suggest the existence of two Src SH3 binding mechanisms, one requiring Asp-99 and the other independent of this residue.	Aspartic Acid	28-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
7565714-7	1995	These results indicate that Asp-99 is important for Src SH3 binding specificity and that Asp-99-dependent binding interactions play a dominant role in Src SH3 recognition of cellular binding proteins, and they suggest the existence of two Src SH3 binding mechanisms, one requiring Asp-99 and the other independent of this residue.	Aspartic Acid	28-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
7565714-7	1995	These results indicate that Asp-99 is important for Src SH3 binding specificity and that Asp-99-dependent binding interactions play a dominant role in Src SH3 recognition of cellular binding proteins, and they suggest the existence of two Src SH3 binding mechanisms, one requiring Asp-99 and the other independent of this residue.	Aspartic Acid	89-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
7565714-7	1995	These results indicate that Asp-99 is important for Src SH3 binding specificity and that Asp-99-dependent binding interactions play a dominant role in Src SH3 recognition of cellular binding proteins, and they suggest the existence of two Src SH3 binding mechanisms, one requiring Asp-99 and the other independent of this residue.	Aspartic Acid	89-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
7565714-7	1995	These results indicate that Asp-99 is important for Src SH3 binding specificity and that Asp-99-dependent binding interactions play a dominant role in Src SH3 recognition of cellular binding proteins, and they suggest the existence of two Src SH3 binding mechanisms, one requiring Asp-99 and the other independent of this residue.	Aspartic Acid	89-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
7565714-7	1995	These results indicate that Asp-99 is important for Src SH3 binding specificity and that Asp-99-dependent binding interactions play a dominant role in Src SH3 recognition of cellular binding proteins, and they suggest the existence of two Src SH3 binding mechanisms, one requiring Asp-99 and the other independent of this residue.	Aspartic Acid	89-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
7565715-5	1995	Therefore, we have constructed a series of cdc34 alleles encoding mutant proteins in which these serine residues have been changed to other amino acid residues, including alanine and aspartic acid.	Aspartic Acid	183-196	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	43-48
8560426-1	1995	The possibility to induce specific disruption of activated platelets by binding of porcine pancreatic phospholipase A2 (PLA2) was tested by constructing a set of PLA2-mutants containing an Arg-Gly-Asp (RGD) sequence.	Aspartic Acid	197-200	phospholipase A2 group IB	Homo sapiens	102-118
8560426-1	1995	The possibility to induce specific disruption of activated platelets by binding of porcine pancreatic phospholipase A2 (PLA2) was tested by constructing a set of PLA2-mutants containing an Arg-Gly-Asp (RGD) sequence.	Aspartic Acid	197-200	phospholipase A2 group IB	Homo sapiens	120-124
7673234-2	1995	We showed previously that replacement of Lys-145 in the IL-1 receptor antagonist (IL-1ra) with Asp resulted in an analog (IL-1ra K145D) with partial agonist activity.	Aspartic Acid	95-98	interleukin 1 receptor antagonist	Homo sapiens	82-88
7673234-2	1995	We showed previously that replacement of Lys-145 in the IL-1 receptor antagonist (IL-1ra) with Asp resulted in an analog (IL-1ra K145D) with partial agonist activity.	Aspartic Acid	95-98	interleukin 1 receptor antagonist	Homo sapiens	122-128
7673182-7	1995	Mutation of two Asp residues flanking Arg221a (D221A/D222K) almost abolishes the allosteric properties of thrombin and shows that the Na+ binding loop is also involved in direct recognition of protein C and antithrombin.	Aspartic Acid	16-19	coagulation factor II, thrombin	Homo sapiens	106-114
7673182-7	1995	Mutation of two Asp residues flanking Arg221a (D221A/D222K) almost abolishes the allosteric properties of thrombin and shows that the Na+ binding loop is also involved in direct recognition of protein C and antithrombin.	Aspartic Acid	16-19	serpin family C member 1	Homo sapiens	207-219
7665562-5	1995	PC2 with the potential oxyanion hole Asp residue changed to Asn was processed and altered several aspects of POMC processing in a manner similar to that of wild-type PC2.	Aspartic Acid	37-40	proopiomelanocortin	Homo sapiens	109-113
7673402-7	1995	In sequence analysis, an unusual mutation of alternate three-base deletions at nucleotides 1953-1957 (AAA GAT ACC to AAG TCC), resulting in one amino acid deletion (Asp at 619) and one conservative amino acid substitution (Thr to Ser at 620), was identified in tumor DNA but not in leukocyte DNA of no.	Aspartic Acid	165-168	glycine-N-acyltransferase	Homo sapiens	106-109
7672128-6	1995	LDLr is proposed to have a beta-sheet structure in which the five biologically important Asp/Glu residues are located on an exposed loop.	Aspartic Acid	89-92	low density lipoprotein receptor	Homo sapiens	0-4
8585604-5	1995	Using the anti-hamster beta 1 monoclonal antibody 7E2 to capture alpha 5 beta 1 from a CHO#7 cell lysate, this SPA assay allowed measurement of specific 125I-fibronectin binding as defined by displacement by the Arg-Gly-Asp containing peptide GRGDSP or the anti-human alpha 5 antibody P1D6.	Aspartic Acid	220-223	fibronectin 1	Homo sapiens	158-169
24394355-8	1995	DQ alpha 52-Arg and DQ beta 57-non-Asp are strongly associated with IDDM susceptibility as compared with controls (p &lt; 0.001 and 0.006, respectively).	Aspartic Acid	35-38	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	20-27
24394355-9	1995	DQ beta 57-non-Asp homozygosity is associated with increased susceptibility to IDDM.	Aspartic Acid	15-18	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	0-7
24394355-11	1995	These results suggest that the effect of the DQ b 57-Asp variation on Chinese IDDM susceptibility is not as remarkable as in Caucasians, and there may be other alleles which contribute to IDDM susceptibility in Chinese individuals.	Aspartic Acid	53-56	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	45-49
8548867-3	1995	The cell adhesive region in the central portion of fibronectin is comprised of at least two minimal amino acid sequences--an Arg-Gly-Asp (RGD) sequence and a Pro-His-Ser-Arg-Asn (PHSRN) sequence--which function in synergy.	Aspartic Acid	133-136	fibronectin 1	Homo sapiens	51-62
7665562-5	1995	PC2 with the potential oxyanion hole Asp residue changed to Asn was processed and altered several aspects of POMC processing in a manner similar to that of wild-type PC2.	Aspartic Acid	37-40	proprotein convertase subtilisin/kexin type 2	Homo sapiens	0-3
8544185-4	1995	The binding sites for carbamyl phosphate in both enzymes are similar and the ornithine binding site in ornithine transcarbamylase appears to be in the same location as the L-aspartate binding site in aspartate transcarbamylase, with negatively charged side chains replaced by positively charged residues.	Aspartic Acid	172-183	ornithine transcarbamylase	Homo sapiens	103-129
7650377-6	1995	The interaction of lambda R with DQ8 was highly dependent on specific sequence polymorphisms at residue 57; an Ala--&gt;Asp substitution on the DQ beta-chain at the polymorphic codon 57 prevented peptide binding.	Aspartic Acid	120-123	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	144-151
7649284-4	1995	We find the most probable binding modes for the two inhibitors to be a folded conformation, with one distal amidino group extending into the S1 pocket, forming a salt-bridge with FXa Asp-189, and the other positively charged group fitting into the S4 subsite, and stabilized by a cation-pi interaction.	Aspartic Acid	183-186	coagulation factor X	Homo sapiens	179-182
7654761-8	1995	N-Terminal amino acid sequencing showed that the 43K c-mos protein has a Asp-Glu-Gly-Gly-Asn-Leu-Gln-sequence located 5" upstream (99 bases upstream) of the rat c-mos coding sequence reported.	Aspartic Acid	73-76	MOS proto-oncogene, serine/threonine kinase	Rattus norvegicus	53-58
7636245-6	1995	Different from these receptors, CD97 has an extended extracellular region of 433 amino acids that possesses three N-terminal epidermal growth factor-like domains, two of them with a calcium-binding site, and a single Arg-Gly-Asp (RGD) motif.	Aspartic Acid	225-228	adhesion G protein-coupled receptor E5	Homo sapiens	32-36
7651730-1	1995	An altered protein expression of Ca(2+)-dependent protein kinase C (PKC) isoforms and a point mutation in the PKC alpha cDNA (position 908 of the nucleotide sequence, position 294 of the amino acid sequence, substitution of an aspartic acid by a glycine) have been previously described in a subpopulation of human pituitary tumors.	Aspartic Acid	227-240	protein kinase C alpha	Homo sapiens	110-119
7642551-6	1995	Mutations at FKBP12 residues Asp-37, Arg-42, His-87, and Ile-90 decrease calcineurin affinity of the mutant FKBP12.FK506 complex by as much as 2600-fold in the case of I90K.	Aspartic Acid	29-32	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	13-19
7642551-6	1995	Mutations at FKBP12 residues Asp-37, Arg-42, His-87, and Ile-90 decrease calcineurin affinity of the mutant FKBP12.FK506 complex by as much as 2600-fold in the case of I90K.	Aspartic Acid	29-32	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	108-114
7639721-5	1995	The thrA and asd expression cassettes were combined into a single plasmid which, when transfected into 3T3 cells, enabled them to produce homoserine from aspartic acid.	Aspartic Acid	154-167	thyroid hormone receptor alpha	Mus musculus	4-8
7629165-6	1995	However, the glutamate substitutions at Asp-489 and Asp-698 severely impaired cell adhesion to VCAM and fibronectin, whereas the substitution at Asp-811 had no detectable effect on cell adhesion.	Aspartic Acid	40-43	fibronectin 1	Homo sapiens	104-115
7629143-8	1995	The adhesive motif RGDS (Arg-Gly-Asp-Ser) and an epidermal growth factor-like domain were identified.	Aspartic Acid	33-36	ral guanine nucleotide dissociation stimulator	Homo sapiens	19-23
8567173-7	1995	Thus, our results conclude that the Glu-21 residue and the common interaction of the terminal Leu-1 alpha-amino group and the Asp-58 carboxyl group are related to the nAChR-binding activity of cobrotoxin, and the free carboxyl groups in cobrotoxin are conformation-essential.	Aspartic Acid	126-129	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	167-172
7582540-0	1995	NMDA-induced glutamate and aspartate release from rat cortical pyramidal neurones: evidence for modulation by a 5-HT1A antagonist.	Aspartic Acid	27-36	5-hydroxytryptamine receptor 1A	Rattus norvegicus	112-118
8523041-8	1995	Our findings suggest that the position of the carboxylate group of Asp116 (TM3) within the receptor pocket depends on whether an agonist or an antagonist binds to the protein; a conformational change of this aspartate residue upon agonist binding is expected to play an essential role in receptor stimulation.	Aspartic Acid	208-217	tropomyosin 3	Homo sapiens	75-78
8543567-2	1995	The amino acid sequence of its NH2-terminus was determined to be Val-Pro-Asn-Ser-Leu-Asp-Trp-Arg-Glu-Lys-Gly-Tyr-Val-Thr-Pro-, which differed from that of rat cathepsin L and was not found in the amino acid sequence data bank.	Aspartic Acid	85-88	cathepsin L	Rattus norvegicus	159-170
7675849-6	1995	Both morphine and D-aspartic acid were previously reported to inhibit L-aspartic acid production via blockade of L-asparaginase.	Aspartic Acid	70-85	asparaginase like 1	Mus musculus	113-127
7476979-1	1995	We previously identified a codon 351 (Asp--&gt;Tyr) mutant estrogen receptor (ER) in a tamoxifen-stimulated human breast tumor line.	Aspartic Acid	38-41	estrogen receptor 1	Homo sapiens	59-76
7476979-1	1995	We previously identified a codon 351 (Asp--&gt;Tyr) mutant estrogen receptor (ER) in a tamoxifen-stimulated human breast tumor line.	Aspartic Acid	38-41	estrogen receptor 1	Homo sapiens	78-80
8589524-3	1995	The difference at amino acid residue 94, (Gpi1-sa GAT Asp, Gpi1-sb AAT Asn) may account for the differing electrophoretic migration, isoelectric point, and thermostability of the two alleles.	Aspartic Acid	54-57	glucose-6-phosphate isomerase 1	Mus musculus	42-46
7478205-2	1995	CCK-8 (10 microM), administrated via a microdialysis probe, produced a significant increase in the levels of aspartate, glutamate and gamma-aminobutyric acid (GABA), but not of 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), lactate and pyruvate, which were simultaneously monitored.	Aspartic Acid	109-118	cholecystokinin	Rattus norvegicus	0-3
7629113-4	1995	The cleavage enzyme, designated SREBP cleavage activity (SCA), belongs to a new class of cysteine proteases of the interleukin-1 beta-converting enzyme (ICE) family, all of which cleave at aspartic acid residues.	Aspartic Acid	189-202	caspase 1	Homo sapiens	153-156
7478205-3	1995	The increase in aspartate and glutamate levels produced by CCK-8 was about 3-4-fold.	Aspartic Acid	16-25	cholecystokinin	Rattus norvegicus	59-62
7478205-4	1995	The effect of CCK-8 on aspartate levels was significantly inhibited by the CCKB antagonist, L-365,260 (20 mg kg-1, s.c.), but not by the CCKA antagonist, L-364,718 (20 mg kg-1, s.c.).	Aspartic Acid	23-32	cholecystokinin	Rattus norvegicus	14-17
7478205-7	1995	The present results show that CCK-8 exerts a strong modulatory action on both aspartate and glutamate release in rat cortex.	Aspartic Acid	78-87	cholecystokinin	Rattus norvegicus	30-33
7608196-1	1995	The sarcoplasmic reticulum ATPase segment extending from the phosphorylation site (Asp-351) to the preceding transmembrane helix M4 (which is involved in Ca2+ binding in conjunction with transmembrane helices M5, M6, and M8) retains a marked sequence homology to the corresponding segments of other cation ATPases.	Aspartic Acid	83-86	carbonic anhydrase 2	Homo sapiens	154-157
7619080-1	1995	Alterations in situ in the phosphorylation state of the microtubule-associated protein tau were examined in response to increasing intracellular levels of Ca2+ through N-methyl-D-aspartate (NMDA)-receptor activation, or activating cyclic AMP (cAMP)-dependent protein kinase (cAMP-PK), in rat cerebral-cortical slices.	Aspartic Acid	179-188	microtubule-associated protein tau	Rattus norvegicus	56-90
7797588-4	1995	The connecting stalk of entactin, E, which contains four cysteine-rich EGF homology repeats and the integrin receptor RGD recognition sequence, has been modified by deletion of the RGD sequence and substituting glutamic acid for aspartic acid.	Aspartic Acid	229-242	nidogen 1	Homo sapiens	24-32
7633464-9	1995	The isolated clone encodes the highly conserved active site residues (His, Asp, Ser) and specificity pocket residues present in bovine chymotrypsinogen B.	Aspartic Acid	75-78	chymotrypsinogen B	Bos taurus	135-153
7664124-2	1995	We present the predicted three-dimensional structure of the major human AP site-specific DNA repair endonuclease, HAP1, and show that an aspartate/histidine pair, in conjunction with a metal ion-coordinating glutamate residue, are critical for catalyzing the multiple repair activities of HAP1.	Aspartic Acid	137-146	huntingtin associated protein 1	Homo sapiens	114-118
7664124-2	1995	We present the predicted three-dimensional structure of the major human AP site-specific DNA repair endonuclease, HAP1, and show that an aspartate/histidine pair, in conjunction with a metal ion-coordinating glutamate residue, are critical for catalyzing the multiple repair activities of HAP1.	Aspartic Acid	137-146	huntingtin associated protein 1	Homo sapiens	289-293
7647303-8	1995	Outside the homeodomain a region rich in aspartate and glutamate residues is found suggesting that ATK1 is a transcriptional activator.	Aspartic Acid	41-50	kinesin 1	Arabidopsis thaliana	99-103
7482501-0	1995	Discrepant sequence at codon 57 of DQB1: implication on HLA typing of "Asp 57" in I.D.D.M.	Aspartic Acid	71-74	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	35-39
7791792-3	1995	This mutation changes an evolutionarily conserved aspartic acid to asparagine within the autoinhibitory domain of the calcineurin A alpha protein.	Aspartic Acid	50-63	protein phosphatase 3, catalytic subunit, alpha isoform	Mus musculus	118-137
7797592-3	1995	Both were highly homologous to human ICE (52% identical) and CED-3 (25% identical) and both contained the absolutely conserved pentapeptide sequence Gln-Ala-Cys-Arg-Asp containing the catalytic cysteine residue.	Aspartic Acid	165-168	caspase 1	Homo sapiens	37-40
7797592-3	1995	Both were highly homologous to human ICE (52% identical) and CED-3 (25% identical) and both contained the absolutely conserved pentapeptide sequence Gln-Ala-Cys-Arg-Asp containing the catalytic cysteine residue.	Aspartic Acid	165-168	intraflagellar transport 43	Homo sapiens	61-66
7773929-5	1995	DNA sequencing of nine cases with K-ras codon 12 point mutations identified seven cases with a single-base substitution of GGT to AGT (glycine to serine) and two with single-base substitution of GGT to AGT (aspartic acid).	Aspartic Acid	207-220	angiotensinogen	Homo sapiens	202-205
7775456-1	1995	The highly conserved aspartic acid residue at position 87 of the Escherichia coli chaperonin GroEL was mutated to glutamic acid.	Aspartic Acid	21-34	GroEL	Escherichia coli	93-98
7791878-3	1995	The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacological profile consistent with previously described cerebellar transport activities.	Aspartic Acid	71-82	solute carrier family 1 member 6	Homo sapiens	34-39
7791878-4	1995	In Xenopus oocytes expressing EAAT4, L-aspartate and L-glutamate elicited a current predominantly carried by chloride ions.	Aspartic Acid	37-48	solute carrier family 1 member 6	Homo sapiens	30-35
7781067-1	1995	We assessed hippocampal-dependent memory in mice with a Ca(2+)-independent form of CaMKII generated by the introduction of an aspartate at amino acid 286.	Aspartic Acid	126-135	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	83-89
7781067-2	1995	The CaMKII-Asp-286 mice show normal LTP at high frequency stimulation, but in the 5-10 Hz range, they show a shift in the frequency-response curve favoring LTD.	Aspartic Acid	11-14	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	4-10
8590017-2	1995	The substitution Gly--&gt;Asp at residue 33 of the cholera toxin B subunit (CTB) has been reported to abolish receptor-binding ability.	Aspartic Acid	26-29	phosphate cytidylyltransferase 1B, choline	Homo sapiens	51-74
8590017-2	1995	The substitution Gly--&gt;Asp at residue 33 of the cholera toxin B subunit (CTB) has been reported to abolish receptor-binding ability.	Aspartic Acid	26-29	phosphate cytidylyltransferase 1B, choline	Homo sapiens	76-79
8590017-5	1995	RESULTS: We now report at a resolution of 2.0 A the crystal structure of a recombinant CTB pentamer containing the Gly33--&gt;Asp substitution.	Aspartic Acid	126-129	phosphate cytidylyltransferase 1B, choline	Homo sapiens	87-90
8590017-9	1995	This same pentamer-pentamer interaction is also present in the crystal structure of a second recombinant CTB containing an Arg--&gt;Asp substitution at residue 35, which we have determined at 2.1 A resolution.	Aspartic Acid	132-135	phosphate cytidylyltransferase 1B, choline	Homo sapiens	105-108
8590019-6	1995	The conformationally constrained Apns-Thp linkage is favorably recognized in its low energy trans conformation, which results in a symmetric mode of binding to the active-site aspartic acids and also explains the unusual preference of HIV PR for the S, or syn, hydroxyl group of the Apns residue.	Aspartic Acid	176-190	synemin	Homo sapiens	256-259
7661866-2	1995	Three schemes of synthesis for pentapeptide Glp-Glu-Asp-Cys-Lys-OH were compared was carried out.	Aspartic Acid	52-55	euchromatic histone lysine methyltransferase 1	Homo sapiens	44-47
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Aspartic Acid	109-112	fibronectin 1	Mus musculus	163-165
7779791-3	1995	This segment of cytochrome b contains one acidic residue, aspartate-160, localized in amphiphilic, non-membrane-spanning, helix cd.	Aspartic Acid	58-67	cytochrome b	Saccharomyces cerevisiae S288C	16-28
7612644-4	1995	We conclude that Glu-246 and Asp-206 constitute an essential part of the binding site for cytochrome c.	Aspartic Acid	29-32	LOC104968582	Bos taurus	90-102
7649217-3	1995	Analysis of the cleavage sites indicated that cathepsin D hydrolyzed the methionine--aspartate bond generating the in vivo amino terminus of A beta.	Aspartic Acid	85-94	cathepsin D	Homo sapiens	46-57
7607208-6	1995	In addition to Glu376, eight other conserved acidic residues (Asp/Glu) in 5-lipoxygenase were replaced, none of which was crucial for enzyme activity.	Aspartic Acid	62-65	arachidonate 5-lipoxygenase	Homo sapiens	74-88
7649217-3	1995	Analysis of the cleavage sites indicated that cathepsin D hydrolyzed the methionine--aspartate bond generating the in vivo amino terminus of A beta.	Aspartic Acid	85-94	amyloid beta precursor protein	Homo sapiens	141-147
7614978-2	1995	These nucleotides are frequently preserved during gene rearrangement, resulting in the common presence of glutamine at position 96 and of aspartate or glutamate at position 97 of the V beta 7.1 chain CDR3 loop in peripheral blood lymphocytes.	Aspartic Acid	138-147	CDR3	Homo sapiens	200-204
7557836-2	1995	Mutant hTSHR cDNAs which encode a hydrophobic peptide (ATVLVVPM) and a hydrophilic peptide (GTTRTVAM) between +572 Met and +573 Asp were transfected into Chinese hamster ovary (CHO) cells to develop F-cell lines and R-cell lines, respectively.	Aspartic Acid	128-131	thyroid stimulating hormone receptor	Homo sapiens	7-12
7577818-5	1995	In the proposed model of the complex, the terminal Gal alpha of Gb3 is located in proximity to aspartates 16-18 of VT1.	Aspartic Acid	95-105	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	64-67
7797079-3	1995	The carboxy-terminal portion of U1-70K-encompassing repeats of Arg/Ser, Arg/Glu, and Arg/Asp localizes to the nucleus independently of U1 RNA and was responsible for these inhibitory effects.	Aspartic Acid	89-92	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	32-38
7538175-7	1995	However, the sequence Asp-Lys-Gly-Gly (amino acids 44 to 47), also found in the B subunit of PP2A, is dispensable for complex formation between MT and PP2A.	Aspartic Acid	22-25	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	93-97
7759490-0	1995	Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit.	Aspartic Acid	64-73	inactive glutathione hydrolase 2	Homo sapiens	6-35
7539004-0	1995	Critical threonine and aspartic acid residues within the I domains of beta 2 integrins for interactions with intercellular adhesion molecule 1 (ICAM-1) and C3bi.	Aspartic Acid	23-36	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	70-76
7539004-0	1995	Critical threonine and aspartic acid residues within the I domains of beta 2 integrins for interactions with intercellular adhesion molecule 1 (ICAM-1) and C3bi.	Aspartic Acid	23-36	intercellular adhesion molecule 1	Homo sapiens	109-142
7539004-0	1995	Critical threonine and aspartic acid residues within the I domains of beta 2 integrins for interactions with intercellular adhesion molecule 1 (ICAM-1) and C3bi.	Aspartic Acid	23-36	intercellular adhesion molecule 1	Homo sapiens	144-150
7539004-9	1995	The mutations of the Asp-137 and Asp-239 of alpha L also block ICAM-1 binding to alpha L beta 2, as do the corresponding Asp residues of alpha 2 or alpha M in collagen/alpha 2 beta 1 or C3bi/alpha M beta 2 interactions, respectively.	Aspartic Acid	21-24	intercellular adhesion molecule 1	Homo sapiens	63-69
7539004-9	1995	The mutations of the Asp-137 and Asp-239 of alpha L also block ICAM-1 binding to alpha L beta 2, as do the corresponding Asp residues of alpha 2 or alpha M in collagen/alpha 2 beta 1 or C3bi/alpha M beta 2 interactions, respectively.	Aspartic Acid	21-24	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-95
7539004-9	1995	The mutations of the Asp-137 and Asp-239 of alpha L also block ICAM-1 binding to alpha L beta 2, as do the corresponding Asp residues of alpha 2 or alpha M in collagen/alpha 2 beta 1 or C3bi/alpha M beta 2 interactions, respectively.	Aspartic Acid	21-24	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	199-205
7539004-9	1995	The mutations of the Asp-137 and Asp-239 of alpha L also block ICAM-1 binding to alpha L beta 2, as do the corresponding Asp residues of alpha 2 or alpha M in collagen/alpha 2 beta 1 or C3bi/alpha M beta 2 interactions, respectively.	Aspartic Acid	33-36	intercellular adhesion molecule 1	Homo sapiens	63-69
7539004-9	1995	The mutations of the Asp-137 and Asp-239 of alpha L also block ICAM-1 binding to alpha L beta 2, as do the corresponding Asp residues of alpha 2 or alpha M in collagen/alpha 2 beta 1 or C3bi/alpha M beta 2 interactions, respectively.	Aspartic Acid	33-36	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-95
7539004-9	1995	The mutations of the Asp-137 and Asp-239 of alpha L also block ICAM-1 binding to alpha L beta 2, as do the corresponding Asp residues of alpha 2 or alpha M in collagen/alpha 2 beta 1 or C3bi/alpha M beta 2 interactions, respectively.	Aspartic Acid	33-36	intercellular adhesion molecule 1	Homo sapiens	63-69
7539004-9	1995	The mutations of the Asp-137 and Asp-239 of alpha L also block ICAM-1 binding to alpha L beta 2, as do the corresponding Asp residues of alpha 2 or alpha M in collagen/alpha 2 beta 1 or C3bi/alpha M beta 2 interactions, respectively.	Aspartic Acid	33-36	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-95
7539005-8	1995	Mutation of the aspartic acids at positions 137 and 239 to either alanine or lysine completely destroyed ICAM-1 binding.	Aspartic Acid	16-30	intercellular adhesion molecule 1	Homo sapiens	105-111
7477728-4	1995	A single mutation was found in the OMGP gene which resulted in an amino-acid change of glycine to aspartic acid.	Aspartic Acid	98-111	oligodendrocyte myelin glycoprotein	Homo sapiens	35-39
7539005-10	1995	This suggests that these aspartic acids are required for binding of human LFA-1 to human ICAM-1.	Aspartic Acid	25-39	integrin subunit alpha L	Homo sapiens	74-79
7539005-10	1995	This suggests that these aspartic acids are required for binding of human LFA-1 to human ICAM-1.	Aspartic Acid	25-39	intercellular adhesion molecule 1	Homo sapiens	89-95
7759491-2	1995	gamma-Glutamyl transpeptidase, an enzyme of central significance in glutathione metabolism, is inactivated by iodoacetamide, which esterifies an active site carboxyl group identified here as that of Asp-422.	Aspartic Acid	199-202	inactive glutathione hydrolase 2	Homo sapiens	0-29
7761465-1	1995	Inositol polyphosphate 1-phosphatase, inositol monophosphate phosphatase, and fructose 1,6-bisphosphatase share a sequence motif, Asp-Pro-(Ile or Leu)-Asp-(Gly or Ser)-(Thr or Ser), that has been shown by crystallographic and mutagenesis studies to bind metal ions and participate in catalysis.	Aspartic Acid	130-133	inositol polyphosphate-1-phosphatase	Homo sapiens	0-36
7761465-1	1995	Inositol polyphosphate 1-phosphatase, inositol monophosphate phosphatase, and fructose 1,6-bisphosphatase share a sequence motif, Asp-Pro-(Ile or Leu)-Asp-(Gly or Ser)-(Thr or Ser), that has been shown by crystallographic and mutagenesis studies to bind metal ions and participate in catalysis.	Aspartic Acid	151-154	inositol polyphosphate-1-phosphatase	Homo sapiens	0-36
7744875-4	1995	In good agreement with our structural model, substitutions at Asn-230, His-280, and Asp-281 selectively impaired the capability of shIL-6R alpha to associate with hgp130 both in vitro and on the cell surface, without affecting its affinity for hIL-6.	Aspartic Acid	84-87	interleukin 6	Homo sapiens	132-137
7659296-3	1995	Basal levels of endogenous extracellular GLU and ASP were increased over 2-fold and 3-fold, respectively, following local administration of the selective 5-hydroxytryptamine (5-HT3) receptor agonist phenylbiguanide (300 microM).	Aspartic Acid	49-52	5-hydroxytryptamine receptor 3A	Rattus norvegicus	175-190
7730655-2	1995	In human IDDM it has been suggested that the presence of an aspartate at position 57 of the DQ beta-chain might be important in determining resistance to development of IDDM.	Aspartic Acid	60-69	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	92-99
7730305-5	1995	This fitting yielded rates which we express relative to that of pyruvate carboxylase: citric acid cycle represented by the irreversible alpha-ketoglutarate dehydrogenase = 0.32; citrate synthase = 0.64; reversal of isocitrate dehydrogenase = 0.52; citrate lyase = 0.33, aspartate shuttle = 0.24, and malate shuttle = 0.44.	Aspartic Acid	270-279	oxoglutarate dehydrogenase	Rattus norvegicus	136-169
7752183-4	1995	Since the 400-411 sequence is required for gamma-chain bioactivity and is a unique recognition sequence among ligands for integrins, vis-a-vis other RGD (Arg-Gly-Asp)-presenting proteins, these turn mimetics may represent a new, selective approach to antagonism of the fibrinogen receptor.	Aspartic Acid	162-165	fibrinogen beta chain	Homo sapiens	269-279
7727443-9	1995	Mutations of glutamine 148, glutamate 154, aspartate 206, aspartate 221, or glutamate 246 lead to a 35-85% decrease in the rate of cytochrome c oxidation.	Aspartic Acid	43-52	cytochrome c, somatic	Equus caballus	131-143
7727443-9	1995	Mutations of glutamine 148, glutamate 154, aspartate 206, aspartate 221, or glutamate 246 lead to a 35-85% decrease in the rate of cytochrome c oxidation.	Aspartic Acid	58-67	cytochrome c, somatic	Equus caballus	131-143
8586006-3	1995	RESULTS: Alleles bearing a codon for an Asp residue at position 57 in the DQ beta-chain were associated with a significantly lower risk of IDDM.	Aspartic Acid	40-43	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	74-81
7722467-4	1995	ICE and granzyme B share the rare substrate site of aspartic acid, after which amino acid cleavage of precursor IL-1 beta (pIL-1 beta) occurs.	Aspartic Acid	52-65	caspase 1	Homo sapiens	0-3
7722467-4	1995	ICE and granzyme B share the rare substrate site of aspartic acid, after which amino acid cleavage of precursor IL-1 beta (pIL-1 beta) occurs.	Aspartic Acid	52-65	granzyme B	Homo sapiens	8-18
7722467-4	1995	ICE and granzyme B share the rare substrate site of aspartic acid, after which amino acid cleavage of precursor IL-1 beta (pIL-1 beta) occurs.	Aspartic Acid	52-65	interleukin 1 beta	Homo sapiens	112-121
7602759-1	1995	We isolated the mouse cytosolic and mitochondrial malate dehydrogenase (cMDH and mMDH) and the mouse cytosolic and mitochondrial aminotransferase (cAspAT and mAspAT) genes functioning in the malate-aspartate shuttle, and localized the DNA regions required for the promoter activity of these isozyme genes.	Aspartic Acid	198-207	glutamic-oxaloacetic transaminase 1, soluble	Mus musculus	147-153
7602759-1	1995	We isolated the mouse cytosolic and mitochondrial malate dehydrogenase (cMDH and mMDH) and the mouse cytosolic and mitochondrial aminotransferase (cAspAT and mAspAT) genes functioning in the malate-aspartate shuttle, and localized the DNA regions required for the promoter activity of these isozyme genes.	Aspartic Acid	198-207	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	158-164
7730301-0	1995	Switching nucleotide specificity of Ha-Ras p21 by a single amino acid substitution at aspartate 119.	Aspartic Acid	86-95	H3 histone pseudogene 16	Homo sapiens	43-46
7538140-7	1995	All of the identified antigens, including the human homolog of yeast Prp22 (HRH1), contain a similar structural element characterized by arginine alternating with serine, glutamate, and/or aspartate.	Aspartic Acid	189-198	DEAH-box ATP-dependent RNA helicase PRP22	Saccharomyces cerevisiae S288C	69-74
7538194-2	1995	An unusual feature of the neurokinin-1 receptor is the presence of glutamic acid (residue 78) in the second putative transmembrane domain, at the location of a highly conserved aspartate residue in the G protein-coupled receptor superfamily.	Aspartic Acid	177-186	tachykinin receptor 1	Rattus norvegicus	26-47
7538194-3	1995	The rat neurokinin-1 receptor cDNA was mutated to lysine, aspartate, and glutamine at this site and functionally expressed in Chinese hamster ovary cells, and clonal cell lines were isolated and characterized.	Aspartic Acid	58-67	tachykinin receptor 1	Rattus norvegicus	8-29
7727418-2	1995	Yeast strains with null alleles of either of these two genes (delta rtg1, delta rtg2) cannot grow on acetate as the sole carbon source and are auxotrophic for glutamate and aspartate.	Aspartic Acid	173-182	Rtg1p	Saccharomyces cerevisiae S288C	68-72
7727418-2	1995	Yeast strains with null alleles of either of these two genes (delta rtg1, delta rtg2) cannot grow on acetate as the sole carbon source and are auxotrophic for glutamate and aspartate.	Aspartic Acid	173-182	Rtg2p	Saccharomyces cerevisiae S288C	80-84
7733983-0	1995	Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells.	Aspartic Acid	0-9	caspase 1	Homo sapiens	29-65
7730355-1	1995	Mutants of each of the four divalent cation binding sites of chicken skeletal muscle troponin C (TnC) were constructed using site-directed mutagenesis to convert Asp to Ala at the first coordinating position in each site.	Aspartic Acid	162-165	tenascin C	Gallus gallus	85-95
7730355-1	1995	Mutants of each of the four divalent cation binding sites of chicken skeletal muscle troponin C (TnC) were constructed using site-directed mutagenesis to convert Asp to Ala at the first coordinating position in each site.	Aspartic Acid	162-165	tenascin C	Gallus gallus	97-100
7731985-5	1995	Substitution of proline for any of the individual acidic residues (Asp-17 and Glu-21, -24, -25, and -29) eliminated the virion incorporation of Vpr and also altered the stability of Vpr in cells.	Aspartic Acid	67-70	Vpr	Human immunodeficiency virus 1	144-147
7731985-5	1995	Substitution of proline for any of the individual acidic residues (Asp-17 and Glu-21, -24, -25, and -29) eliminated the virion incorporation of Vpr and also altered the stability of Vpr in cells.	Aspartic Acid	67-70	Vpr	Human immunodeficiency virus 1	182-185
7733658-3	1995	By site-directed mutagenesis, three mutant forms of recombinant guinea-pig liver transglutaminase, in which some acidic amino acid residues in two conserved regions became nonionic, were expressed in Escherichia coli: TGM1, with Asp-231 and -232 changed to Asn; TGM2, with Glu-445, -448, -449, -450, and -452 changed to Gln; and TGM3, with the mutations of both TGM1 and TGM2.	Aspartic Acid	229-232	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	81-97
7713895-2	1995	Our results are consistent with the involvement of Asp-333 and His-523 in a catalytic mechanism similar to that of other alpha/beta hydrolase fold enzymes.	Aspartic Acid	51-54	abhydrolase domain containing 15	Mus musculus	121-141
7614005-4	1995	In the CD1 mice, NH3 content was increased while that of Asp decreased.	Aspartic Acid	57-60	CD1 antigen complex	Mus musculus	7-10
7614005-11	1995	The cortical and striatal changes may indicate a lesser GABA supply in C57 strain and some Asp release in CD1 strain.	Aspartic Acid	91-94	CD1 antigen complex	Mus musculus	106-109
7713895-9	1995	The purified Asp-333--&gt;Asn mutant bound 6% of the substrate compared to the wild-type soluble epoxide hydrolase.	Aspartic Acid	13-16	epoxide hydrolase 2, cytoplasmic	Mus musculus	89-114
7713896-7	1995	Studies conducted with P2-derived peptides suggest that the conformation-specific antibody is directed to an acidic tripeptide, Asp-Glu-Glu, and this sequence is also present in the cytoplasmic domain of the epidermal growth factor receptor.	Aspartic Acid	128-131	epidermal growth factor receptor	Homo sapiens	208-240
7641295-8	1995	Amino acid sequence of CBP-140 contains a carboxyl-terminal Asn-Asp-Glu-Leu (NDEL) sequence, which resembles Lys-Asp-Glu-Leu (KDEL) sequence, a signal to retain the resident proteins in endoplasmic reticulum; NDEL sequence may indeed play a similar role.	Aspartic Acid	64-67	hypoxia up-regulated 1	Mus musculus	23-30
7641295-8	1995	Amino acid sequence of CBP-140 contains a carboxyl-terminal Asn-Asp-Glu-Leu (NDEL) sequence, which resembles Lys-Asp-Glu-Leu (KDEL) sequence, a signal to retain the resident proteins in endoplasmic reticulum; NDEL sequence may indeed play a similar role.	Aspartic Acid	113-116	hypoxia up-regulated 1	Mus musculus	23-30
7536501-0	1995	Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3.	Aspartic Acid	19-32	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	71-101
7781967-2	1995	The primary structure of VIP from both species was the same: His-Ser-Asp-Ala-Ile-Phe-Thr-Asp-Asn-Tyr10- Ser-Arg-Phe-Arg-Lys-Gln-Met-Ala-Val-Lys20-Lys-Tyr-Leu-Asn-Ser-Val- Leu-Thr.	Aspartic Acid	69-72	vasoactive intestinal peptide	Gallus gallus	25-28
7789757-2	1995	We cloned the MRE11 gene and found that it encodes a 643-amino acid protein with a highly acidic region containing a heptad repeat of Asp at its C-terminus and is located downstream of YMR44 near the RNA1 locus on the right arm of chromosome XIII.	Aspartic Acid	134-137	MRX complex nuclease subunit	Saccharomyces cerevisiae S288C	14-19
7628118-7	1995	Direct sequencing of the triosephosphate isomerase gene revealed homozygosity for the formerly described GAG--&gt;GAC-mutation changing 104 Glu--&gt;Asp.	Aspartic Acid	149-152	triosephosphate isomerase 1	Homo sapiens	25-50
7536501-7	1995	Since mutations at the same Asp codon constitutively activated KIT in all the human HMC-1, murine P-815, and rat RBL-2H3 cell lines, and since the incorporation of antisense oligonucleotides of c-kit messenger RNA significantly suppressed the proliferation of RBL-2H3 cells, the activating mutations in the Asp codon of the c-kit gene appeared to be involved in neoplastic growth of mast cells.	Aspartic Acid	28-31	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	63-66
7542253-0	1995	Site-directed mutagenesis of the arginine-glycine-aspartic acid sequence in osteopontin destroys cell adhesion and migration functions.	Aspartic Acid	50-63	secreted phosphoprotein 1	Mus musculus	76-87
7714085-1	1995	A single point mutation that encodes an aspartic acid (Asp578) to glycine substitution in the LH/CG receptor (LH/CGR) gene, D578G, was recently found in American patients with familial male-limited precocious puberty and in a Japanese patient with a sporadic form of the disorder.	Aspartic Acid	40-53	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	94-108
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Aspartic Acid	19-22	secreted phosphoprotein 1	Mus musculus	75-78
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Aspartic Acid	19-22	fibronectin 1	Mus musculus	94-105
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Aspartic Acid	19-22	vitronectin	Mus musculus	110-121
7714085-1	1995	A single point mutation that encodes an aspartic acid (Asp578) to glycine substitution in the LH/CG receptor (LH/CGR) gene, D578G, was recently found in American patients with familial male-limited precocious puberty and in a Japanese patient with a sporadic form of the disorder.	Aspartic Acid	40-53	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	110-116
7533851-5	1995	The 8.7 variant exhibits a change in the epitope 32-42 (Val-35--&gt;Leu), and variant CL1.2 exhibits a change in the epitope 275-289 (Asn-280--&gt;Asp) of the wild-type LCMV-WE.	Aspartic Acid	147-150	adhesion G protein-coupled receptor L1	Homo sapiens	86-89
7897227-6	1995	From the amino acid sequence of the dodecapeptide Gly-Ser-Val-Ser-Asp-Glu-Glu-Met-Met-Glu-Leu-Arg, the phosphorylation site of pp65 was located at the N-terminal region adjacent to the first Ca2+ binding domain.	Aspartic Acid	66-69	lymphocyte cytosolic protein 1	Mus musculus	127-131
7891083-0	1995	Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands.	Aspartic Acid	25-34	carbonic anhydrase 1	Rattus norvegicus	40-43
7891083-0	1995	Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands.	Aspartic Acid	82-91	carbonic anhydrase 1	Rattus norvegicus	40-43
7891083-2	1995	When challenged for 1 min with either 25 mM K+ or 300 microM 4-aminopyridine, CA1 synaptosomes released both glutamate and aspartate in Ca(2+)-dependent manner.	Aspartic Acid	123-132	carbonic anhydrase 1	Rattus norvegicus	78-81
7540935-3	1995	Comparison with the structures of four different RT and non-nucleoside inhibitor complexes reveals that only minor domain rearrangements occur, but there is a significant repositioning of a three-stranded beta-sheet in the p66 subunit (containing the catalytic aspartic acid residues 110, 185 and 186) with respect to the rest of the polymerase site.	Aspartic Acid	261-274	DNA polymerase delta 3, accessory subunit	Homo sapiens	223-226
7706240-3	1995	In the present study we have determined that replacement of Ser142 of CREB with Asp greatly decreases the ability of the cAMP-dependent protein kinase to activate CREB.	Aspartic Acid	80-83	cAMP responsive element binding protein 1	Homo sapiens	70-74
7647578-5	1995	Three types of substitution were identified in FRAG(2044-2295): Asn715 (AAC) --&gt; Asp(GAC) from one papillary cancer, Lys723 (AAG) --&gt; Met(ATG) from one papillary cancer, and Asp 727 (GAC) --&gt; Glu(GAG) from one normal tissue sample, one follicular cancer, and four papillary cancers.	Aspartic Acid	84-87	glycine-N-acyltransferase	Homo sapiens	72-75
7706240-3	1995	In the present study we have determined that replacement of Ser142 of CREB with Asp greatly decreases the ability of the cAMP-dependent protein kinase to activate CREB.	Aspartic Acid	80-83	cAMP responsive element binding protein 1	Homo sapiens	163-167
7698331-0	1995	Aspartate mutation distinguishes ETA but not ETB receptor subtype-selective ligand binding while abolishing phospholipase C activation in both receptors.	Aspartic Acid	0-9	endothelin receptor type A	Homo sapiens	33-36
7698346-3	1995	By site directed mutagenesis of the cloned bovine and porcine V2 receptors we identified a residue (Asp-103) in the first extracellular loop of vasopressin receptors which is responsible for high affinity binding of dDAVP.	Aspartic Acid	100-103	arginine vasopressin	Homo sapiens	144-155
7708754-6	1995	The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.	Aspartic Acid	12-15	angiogenin	Homo sapiens	47-50
7708754-6	1995	The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.	Aspartic Acid	12-15	angiogenin	Homo sapiens	94-97
7708758-7	1995	Further analysis of this region by site-directed mutagenesis showed that a single change at residue 174 of LD4 to the corresponding residue of Rho GDI (i.e., Asp-174--&gt;Ile) could impart nearly full (70%) Rho GDI activity on the LD4 molecule.	Aspartic Acid	158-161	Rho GDP dissociation inhibitor alpha	Homo sapiens	143-150
7708758-7	1995	Further analysis of this region by site-directed mutagenesis showed that a single change at residue 174 of LD4 to the corresponding residue of Rho GDI (i.e., Asp-174--&gt;Ile) could impart nearly full (70%) Rho GDI activity on the LD4 molecule.	Aspartic Acid	158-161	Rho GDP dissociation inhibitor alpha	Homo sapiens	207-214
7896799-2	1995	Replacement of Asp-78 of both subunits with Glu, Ala, or Asn reduced dGK and dAK activities to less than 0.2%, whereas replacement of Arg-79 with Lys, either on both subunits in tandem (R79K), or on the dGK subunit only (R79K:dGK), yielded active but kinetically modified enzymes.	Aspartic Acid	15-18	Diacyl glycerol kinase	Drosophila melanogaster	69-72
7698331-7	1995	Receptor models indicated that aspartic acids located one helical turn above (Asp133) and below (Asp126) Tyr129 in ETA had their side chains directed toward the putative binding cavity.	Aspartic Acid	31-45	endothelin receptor type A	Homo sapiens	115-118
7698331-9	1995	Asp126 in ETA and Asp147 in ETB correspond to the highly conserved aspartate present in TM2 of many GPCR that has frequently been shown to be crucial for agonist efficacy.	Aspartic Acid	67-76	endothelin receptor type A	Homo sapiens	10-13
7698331-9	1995	Asp126 in ETA and Asp147 in ETB correspond to the highly conserved aspartate present in TM2 of many GPCR that has frequently been shown to be crucial for agonist efficacy.	Aspartic Acid	67-76	endothelin receptor type B	Homo sapiens	28-31
7728775-0	1995	CD8+ T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (Gly13--&gt;Asp), are cytotoxic towards a carcinoma cell line harbouring the same mutation.	Aspartic Acid	108-111	CD8a molecule	Homo sapiens	0-3
7893672-6	1995	The basic groups interact with backbone carbonyl groups, water molecules, and an aspartic acid side chain (Asp189) located in the thrombin S1 specificity pocket.	Aspartic Acid	81-94	coagulation factor II, thrombin	Homo sapiens	130-138
7773676-2	1995	Omission of Ca2+ ions from the superfusion media completely abolished the EtOH-induced release of Asp but not that of Glu.	Aspartic Acid	98-101	carbonic anhydrase 2	Rattus norvegicus	12-15
7542013-2	1995	Within the Leydig cell cytoplasm, immunocytochemical results suggested the occurrence of factors known to activate NOS-I such as glutamate and aspartate, as well as molecules involved in the regulation of the NOS-I activity such as calmodulin and Ca2+/calmodulin-dependent protein kinase II.	Aspartic Acid	143-152	nitric oxide synthase 1, neuronal	Mus musculus	115-120
7890753-8	1995	Cells transfected with the Swedish mutation and treated with bafA1 did not produce these alternative A beta peptides, so that bafA1 treatment resulted in a decrease of A beta starting at aspartate 1.	Aspartic Acid	187-196	amyloid beta precursor protein	Homo sapiens	168-174
7890672-6	1995	These residues include Gly-30 and Asp-49, which are conserved in all sPLA2s.	Aspartic Acid	34-37	phospholipase A2 group IID	Homo sapiens	69-75
7728775-0	1995	CD8+ T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (Gly13--&gt;Asp), are cytotoxic towards a carcinoma cell line harbouring the same mutation.	Aspartic Acid	108-111	H3 histone pseudogene 16	Homo sapiens	72-75
7531439-6	1995	The role of Asp-130 of beta 1 in the binding to VCAM-1 and CS-1 peptide was examined.	Aspartic Acid	12-15	vascular cell adhesion protein 1	Cricetulus griseus	48-54
7775978-2	1995	Potentiometric and spectroscopic (absorption, circular dichroism and electron paramagnetic resonance) study on the coordination of two angiotensin II fragments (Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His) to Cu(II) ions has shown that competition between amino and imidazole nitrogens to anchor metal ions is a complicated process and may lead to formation of macrochelate rings.	Aspartic Acid	161-164	angiotensinogen	Homo sapiens	135-149
7864821-3	1995	and partial chemical unblocking procedures, it is shown that the mature form of lysyl oxidase begins at residue Asp-169 of the precursor protein (numbered according to the human sequence).	Aspartic Acid	112-115	lysyl oxidase	Homo sapiens	80-93
7705418-9	1995	TcR V beta 8.2 reactivity to Mtv-7 was shown to be brought by the 38CH strain and to result from an amino acid substitution (Asn--&gt;Asp) in position 19 on the TcR V beta 8.2 fragment.	Aspartic Acid	134-137	T cell receptor alpha variable 6-3	Mus musculus	0-3
7705418-9	1995	TcR V beta 8.2 reactivity to Mtv-7 was shown to be brought by the 38CH strain and to result from an amino acid substitution (Asn--&gt;Asp) in position 19 on the TcR V beta 8.2 fragment.	Aspartic Acid	134-137	mammary tumor virus locus 7	Mus musculus	29-34
7705418-9	1995	TcR V beta 8.2 reactivity to Mtv-7 was shown to be brought by the 38CH strain and to result from an amino acid substitution (Asn--&gt;Asp) in position 19 on the TcR V beta 8.2 fragment.	Aspartic Acid	134-137	T cell receptor alpha variable 6-3	Mus musculus	161-164
7883834-5	1995	Subsequently, digestion of polymerase chain reaction-amplified portions of exon 4 of the apo E gene with endonucleases HaeIII, TaqI, and Sau3AI demonstrated a second DNA variant that encoded a single amino acid substitution (gly127--&gt;asp, G127D) due to a guanosine-to-adenosine nucleotide change resulting in the apo E1 isoform (G127D, R158C), which had arisen from a parent apo E2 allele.	Aspartic Acid	237-240	apolipoprotein E	Homo sapiens	89-94
7861146-0	1995	Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.	Aspartic Acid	28-37	carbonic anhydrase 1	Homo sapiens	78-81
7861146-1	1995	Slices of hippocampal area CA1 were used to test inhibitors of arachidonic acid metabolism for their effects on glutamate/aspartate release from the CA3-derived Schaffer collateral, commissural, and ipsilateral associational terminals.	Aspartic Acid	122-131	carbonic anhydrase 3	Homo sapiens	149-152
7861146-6	1995	These results suggest that a 5-lipoxygenase product selectively enhances aspartate release and a cyclooxygenase product selectively depresses glutamate release.	Aspartic Acid	73-82	arachidonate 5-lipoxygenase	Homo sapiens	29-43
7861146-9	1995	Activation of NMDA receptors may enhance the K(+)-evoked release of glutamate and aspartate from CA1 slices by stimulating the production and release of lipid modulators.	Aspartic Acid	82-91	carbonic anhydrase 1	Homo sapiens	97-100
7848273-13	1995	We therefore modified the MIP26 molecule using a site-directed mutagenesis method to generate a mutant MIP26 at the appropriate asparagine residue (Asn244--&gt;Asp) near the C-terminus.	Aspartic Acid	160-163	major intrinsic protein of lens fiber	Rattus norvegicus	26-31
7848273-13	1995	We therefore modified the MIP26 molecule using a site-directed mutagenesis method to generate a mutant MIP26 at the appropriate asparagine residue (Asn244--&gt;Asp) near the C-terminus.	Aspartic Acid	160-163	major intrinsic protein of lens fiber	Rattus norvegicus	103-108
7896186-1	1995	Tumorigenic roles were variably suggested for HER-2 and INT-2 oncogene amplifications and the "atypical" aspartate to glycine mutability in the butyrylcholinesterase (BCHE) gene in ovarian adenocarcinomas.	Aspartic Acid	105-114	butyrylcholinesterase	Homo sapiens	144-165
7795148-0	1995	Hybrid peptide containing RGDF (Arg-Gly-Asp-Phe) coupled with the carboxy terminal part of alpha 2-antiplasmin capable of inhibiting platelet aggregation and promoting fibrinolysis.	Aspartic Acid	40-43	serpin family F member 2	Homo sapiens	91-110
7795154-3	1995	In two families the mutation (6460 AAC--&gt;GAC) results in an asparagine to aspartate substitution and is associated with normal immunological levels of antithrombin but a reduction in functional activity.	Aspartic Acid	77-86	serpin family C member 1	Homo sapiens	154-166
7833466-4	1995	The glycine at this position in antigen Fya exchanges with aspartic acid in antigen Fyb.	Aspartic Acid	59-72	FYN binding protein 1	Homo sapiens	84-87
7896081-3	1995	Oligonucleotide mediated site-directed mutagenesis of PIS at codon 114 revealed that mutant genes with codons for Ala, Thr and Leu could support yeast cell growth in vivo, but those for Asp, Lys and Tyr could not.	Aspartic Acid	186-189	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	54-57
7538414-2	1995	We have expressed a recombinant 20 kDa cell-binding fragment of human fibronectin consisting of the ninth and tenth type III modules, which includes the Arg-Gly-Asp (RGD) cell recognition site and a second cell adhesive domain that acts synergistically with the RGD site.	Aspartic Acid	161-164	fibronectin 1	Homo sapiens	70-81
7756179-7	1995	To mimic the temperature-sensitive mutant of yeast nuc2, an H-NUC mutant was made in which the highly conserved glycine 640 residue was changed to aspartic acid.	Aspartic Acid	147-160	tRNA (uracil(54)-C(5))-methyltransferase	Saccharomyces cerevisiae S288C	51-55
7756179-7	1995	To mimic the temperature-sensitive mutant of yeast nuc2, an H-NUC mutant was made in which the highly conserved glycine 640 residue was changed to aspartic acid.	Aspartic Acid	147-160	cell division cycle 27	Homo sapiens	60-65
7540635-6	1995	We now report that the Arg-Gly-Asp-mimetics specifically inhibited the binding of murine T cells to fibronectin, but did not affect the proliferative response of these cells in vitro.	Aspartic Acid	31-34	fibronectin 1	Mus musculus	100-111
8590320-0	1995	Overcoming the metastasis-enhancing potential of human tumor necrosis factor alpha by introducing the cell-adhesive Arg-Gly-Asp sequence.	Aspartic Acid	124-127	tumor necrosis factor	Homo sapiens	55-82
8590320-1	1995	A mutein, F4168, of human tumor necrosis factor alpha (hTNF-alpha) containing the cell-adhesive Arg-Gly-Asp (RGD) sequence near the N terminus was constructed.	Aspartic Acid	104-107	tumor necrosis factor	Homo sapiens	26-53
7836909-6	1995	Introduction of the DR17-specific contact site aspartate at P4 dramatically improves invariant chain-peptide binding to DR17, but reduces DR1 binding.	Aspartic Acid	47-56	down-regulator of transcription 1	Homo sapiens	20-23
8590320-1	1995	A mutein, F4168, of human tumor necrosis factor alpha (hTNF-alpha) containing the cell-adhesive Arg-Gly-Asp (RGD) sequence near the N terminus was constructed.	Aspartic Acid	104-107	tumor necrosis factor	Homo sapiens	55-65
7746359-6	1995	However, CGRP has a more potent effect in suppressing aspartate- and quisqualate-induce activity as compared to that elicited by glutamate.	Aspartic Acid	54-63	calcitonin related polypeptide alpha	Homo sapiens	9-13
7846071-0	1995	Dark-light: model for nightblindness from the human rhodopsin Gly-90--&gt;Asp mutation.	Aspartic Acid	74-77	rhodopsin	Homo sapiens	52-61
7773301-13	1995	The G1236--&gt;A mutation in exon 8 of CYP2C9 (Gly417--&gt;Asp) creates a Hph I site.	Aspartic Acid	59-62	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	39-45
7829507-10	1995	These results provide direct evidence for high capacity, cooperative and specific binding of Ca2+ to conformationally labile aspartate-rich repeats of TSP1.	Aspartic Acid	125-134	thrombospondin 1	Homo sapiens	151-155
7846071-1	1995	A human rhodopsin mutation, Gly-90--&gt;Asp (Gly90Asp), cosegregated with an unusual trait of congenital nightblindness in 22 at-risk members of a large autosomal dominant kindred.	Aspartic Acid	40-43	rhodopsin	Homo sapiens	8-17
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Aspartic Acid	110-113	CD8a molecule	Homo sapiens	73-76
7827057-7	1995	As in other parvalbumins, the liganding residues in the CD and EF sites of oncomodulin differ at the +z and -x coordination positions: serine and aspartate, respectively, in the CD site; aspartate and glycine in the EF site.	Aspartic Acid	146-155	oncomodulin	Homo sapiens	75-86
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Aspartic Acid	110-113	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	81-84
7827057-7	1995	As in other parvalbumins, the liganding residues in the CD and EF sites of oncomodulin differ at the +z and -x coordination positions: serine and aspartate, respectively, in the CD site; aspartate and glycine in the EF site.	Aspartic Acid	187-196	oncomodulin	Homo sapiens	75-86
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Aspartic Acid	110-113	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	155-158
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Aspartic Acid	110-113	CD8a molecule	Homo sapiens	177-180
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Aspartic Acid	110-113	CD8a molecule	Homo sapiens	177-180
7811728-0	1995	Hemoglobin Roanne [alpha 94(G1) Asp--&gt;Glu]: a variant of the alpha 1 beta 2 interface with an unexpected high oxygen affinity.	Aspartic Acid	32-35	proline rich protein BstNI subfamily 3	Homo sapiens	0-30
7851432-1	1995	Human serum albumin prepared by blood fractionation for clinical purposes was found to degrade when stored at or above 30 degree C. Mass spectrometry and N-terminal sequencing of the protein identified degradation corresponding to the loss of the first two residues, aspartic acid and alanine.	Aspartic Acid	267-280	albumin	Homo sapiens	12-19
7840781-8	1995	Antibodies raised against a truncated peptide (Tyr-Lys-Asp-Asn), representing the C-terminal half of the peptide, also bound to glucose-6-phosphate dehydrogenase, but failed to bind to CYP1A2; thus although the C-terminal region of the peptide 290-296 is strongly immunogenic, it appears that it is not this population of antibodies that binds to CYP1A2.	Aspartic Acid	55-58	glucose-6-phosphate dehydrogenase	Rattus norvegicus	128-161
7818527-0	1995	Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP.	Aspartic Acid	17-26	vasoactive intestinal peptide	Homo sapiens	114-117
7818527-0	1995	Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP.	Aspartic Acid	17-26	vasoactive intestinal peptide	Homo sapiens	165-168
8616107-9	1995	In stage I disease, the median survival was 46 months in those patients whose tumors had no K-ras mutations and 21 months in those with aspartic acid and serine mutations at K-ras codon 12; in patients with stage IIIA disease, median survival time was 16 months in the K-ras negative group and 7 months in the aspartic acid and serine mutation group.	Aspartic Acid	310-323	KRAS proto-oncogene, GTPase	Homo sapiens	174-179
7825568-5	1995	A G-to-A transition at codon 209-in exon 8 of the PFK-M gene, changing an encoded Gly to Asp, is responsible for the disease in a homozygous French Canadian patient.	Aspartic Acid	89-92	phosphofructokinase, muscle	Homo sapiens	50-55
8616107-9	1995	In stage I disease, the median survival was 46 months in those patients whose tumors had no K-ras mutations and 21 months in those with aspartic acid and serine mutations at K-ras codon 12; in patients with stage IIIA disease, median survival time was 16 months in the K-ras negative group and 7 months in the aspartic acid and serine mutation group.	Aspartic Acid	310-323	KRAS proto-oncogene, GTPase	Homo sapiens	174-179
7813806-4	1995	Asp-57 DQB was present among 28% of patients, indicating that this residue alone does not confer protection.	Aspartic Acid	0-3	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	7-10
7541702-5	1995	Double labeling of c-fos with various cytochemical markers revealed that about one-third of the c-fos-immunoreactive neurons were choline acetyltransferase immunoreactive, about one-third were glutamate immunoreactive, and about one-third were aspartate immunoreactive.	Aspartic Acid	244-253	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-24
8665266-0	1995	Glucagon-like peptide-1(7-36)amide induces the release of aspartic acid and glutamine by the ventromedial hypothalamus of the conscious rat.	Aspartic Acid	58-71	glucagon	Rattus norvegicus	0-23
8665266-3	1995	GLP-1(7-36)amide produced an immediate increase in the extracellular concentrations of aspartic acid and glutamine, p &lt; 0.01 and p &lt; 0.05, respectively.	Aspartic Acid	87-100	glucagon	Rattus norvegicus	0-5
8665266-5	1995	The results of this study show a stimulatory effect of GLP-1(7-36)amide on the release of aspartic acid and glutamine by the ventromedial hypothalamus of the rat.	Aspartic Acid	90-103	glucagon	Rattus norvegicus	55-60
8575267-4	1995	With the reference values chosen at fx = 1, the most hydrophobic residues of elastin, Tyr (Y) and Phe (F), have low values of Tt, -55 and -30 degrees C, respectively, and the most hydrophilic residues, Glu (E-), Asp (D-) and Lys (K+), have high values of 250, 170 and 120 degrees C, respectively.	Aspartic Acid	212-215	elastin	Homo sapiens	77-84
8608088-1	1995	The tetrapeptide, Arg-Gly-Asp-Ser (RGDS), which corresponds to a core sequence of cell adhesion proteins, was coimmobilized with insulin on to surface-hydrolyzed poly(methyl methacrylate) film.	Aspartic Acid	26-29	ral guanine nucleotide dissociation stimulator	Mus musculus	35-39
7821750-4	1995	However, replacement of Asp-265, which make contacts with the primary GlcNac sugar residue and is covalently attached to Asn-297, resulted in loss of recognition of both Fc gamma RI and Fc gamma RII.	Aspartic Acid	24-27	Fc gamma receptor Ia	Homo sapiens	170-181
7821750-4	1995	However, replacement of Asp-265, which make contacts with the primary GlcNac sugar residue and is covalently attached to Asn-297, resulted in loss of recognition of both Fc gamma RI and Fc gamma RII.	Aspartic Acid	24-27	Fc receptor, IgG, low affinity IIb	Mus musculus	186-198
7821750-5	1995	Similarly, replacement of Asp-265 in mouse IgG2b resulted in loss of recognition by mouse Fc gamma RII.	Aspartic Acid	26-29	immunoglobulin heavy constant gamma 2B	Mus musculus	43-48
7821750-5	1995	Similarly, replacement of Asp-265 in mouse IgG2b resulted in loss of recognition by mouse Fc gamma RII.	Aspartic Acid	26-29	Fc receptor, IgG, low affinity IIb	Mus musculus	90-102
8630437-1	1995	L-asparaginase and L-aspartate aminotransferase are both involved in the synthesis of L-aspartic acid.	Aspartic Acid	86-101	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	0-14
8630437-5	1995	These observations lead us to suggest that L-asparaginase is the enzyme mainly responsible for the synthesis of the L-aspartic acid necessary for satisfying the living requirements of lymphoid cells.	Aspartic Acid	116-131	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	43-57
8527165-5	1995	We suggest that the aspartate substitution alters the C-terminal end of the D-helix in such way that the analogue still binds to the human IL-4 receptor alpha-chain and signals through the murine gamma c-chain.	Aspartic Acid	20-29	interleukin 4 receptor	Homo sapiens	139-152
8527165-5	1995	We suggest that the aspartate substitution alters the C-terminal end of the D-helix in such way that the analogue still binds to the human IL-4 receptor alpha-chain and signals through the murine gamma c-chain.	Aspartic Acid	20-29	interleukin 2 receptor, gamma chain	Mus musculus	196-203
8808011-3	1995	Long-term treatment with human recombinant growth hormone normalized plasma alanine, glutamine, and glutamic acid levels, increased the OH-Pro concentration, and did not alter the amino acid ratios of Gly/Val, Phe/Tyr, Ser/Gly, and Asn/Asp, but the Gln/Glu ratio approached the normal value.	Aspartic Acid	236-239	growth hormone 1	Homo sapiens	43-57
7775004-7	1995	For peptide 1 the absolute shifts for the free vs. Fab-bound peptide were found to be largest for the amide groups of Asp-1 and Asp-6, in agreement with classification of these residues as critical by the phage display library selection process.	Aspartic Acid	118-121	FA complementation group B	Homo sapiens	51-54
7830031-4	1995	One of these is an exon 15 missense mutation, changing amino acid 442 of CETP from aspartate to glycine.	Aspartic Acid	83-92	cholesteryl ester transfer protein	Homo sapiens	73-77
7983752-0	1995	The highly conserved aspartic acid residue between hypervariable regions 1 and 2 of human immunodeficiency virus type 1 gp120 is important for early stages of virus replication.	Aspartic Acid	21-34	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	120-125
8750611-2	1995	The apolipoprotein E genotyping carried out from leukocyte DNA using PCR amplification and restriction enzyme digestion demonstrated homozygosity for the rare apoE1[Gly127--&gt;Asp; Arg158--&gt; Cys] (Weisgraber allele).	Aspartic Acid	177-180	apolipoprotein E	Homo sapiens	4-20
10188794-0	1995	Mutations of aspartate 103 in the Hm2 receptor and alterations in receptor binding properties of muscarinic agonists.	Aspartic Acid	13-22	cholinergic receptor muscarinic 2	Homo sapiens	34-37
7837791-2	1995	BACKGROUND: Osteopontin (OPN) is a phosphorylated glycoprotein that contains a functional Gly-Arg-Gly-Asp-Ser (GRGDS) cell-binding sequence.	Aspartic Acid	102-105	secreted phosphoprotein 1	Homo sapiens	12-23
7837791-2	1995	BACKGROUND: Osteopontin (OPN) is a phosphorylated glycoprotein that contains a functional Gly-Arg-Gly-Asp-Ser (GRGDS) cell-binding sequence.	Aspartic Acid	102-105	secreted phosphoprotein 1	Homo sapiens	25-28
10188794-1	1995	Aspartate 103 (D103) in the third transmembrane domain of the Hm2 receptor was mutated to glutamate (D103E), asparagine (D103N), or alanine (D103A).	Aspartic Acid	0-9	cholinergic receptor muscarinic 2	Homo sapiens	62-65
21043620-4	1995	Thrombin-stimulated platelets but not non-stimulated platelets adhered to the SCSb-9coated surface, and platelet adherence was inhibited in a dose-dependent manner by the tetrapeptide RGDS (Arg-Gly-Asp-Ser).	Aspartic Acid	198-201	coagulation factor II, thrombin	Homo sapiens	0-8
7894512-10	1995	These molecular studies shed light on the subcellular synthesis of aspartate in Arabidopsis and suggest that some of the AspAT isoenzymes may play overlapping roles in plant nitrogen metabolism.	Aspartic Acid	67-76	aspartate aminotransferase	Arabidopsis thaliana	121-126
21043620-4	1995	Thrombin-stimulated platelets but not non-stimulated platelets adhered to the SCSb-9coated surface, and platelet adherence was inhibited in a dose-dependent manner by the tetrapeptide RGDS (Arg-Gly-Asp-Ser).	Aspartic Acid	198-201	ral guanine nucleotide dissociation stimulator	Homo sapiens	184-188
7703435-0	1994	PAF antagonist, BN52021, inhibits [3H]D-aspartate release after ischaemia in vitro.	Aspartic Acid	40-49	PCNA clamp associated factor	Rattus norvegicus	0-3
7884961-5	1995	Point mutation at codon 54 [Exon 2, GAC (Asp)--&gt;GGC(Gly)] was also demonstrated on the beta-sheet of CK-MM.	Aspartic Acid	41-44	creatine kinase, M-type	Homo sapiens	104-109
8679272-1	1995	In order to elucidate the relationship between N-, C-termini of TNF alpha and it"s biological activity, a TNF alpha derivative 10 (TNF alpha D10) was prepared by changing amino acid at the N-terminus positions Ser(4), Ser(5), Asp(10) and C-terminus position Leu(157) to N-terminus Cys(4), Thr(5), Arg(10) and C-terminus Phe(157) with PCR site-directed mutagenesis.	Aspartic Acid	226-229	tumor necrosis factor	Homo sapiens	64-73
8679272-1	1995	In order to elucidate the relationship between N-, C-termini of TNF alpha and it"s biological activity, a TNF alpha derivative 10 (TNF alpha D10) was prepared by changing amino acid at the N-terminus positions Ser(4), Ser(5), Asp(10) and C-terminus position Leu(157) to N-terminus Cys(4), Thr(5), Arg(10) and C-terminus Phe(157) with PCR site-directed mutagenesis.	Aspartic Acid	226-229	tumor necrosis factor	Homo sapiens	106-115
8679272-1	1995	In order to elucidate the relationship between N-, C-termini of TNF alpha and it"s biological activity, a TNF alpha derivative 10 (TNF alpha D10) was prepared by changing amino acid at the N-terminus positions Ser(4), Ser(5), Asp(10) and C-terminus position Leu(157) to N-terminus Cys(4), Thr(5), Arg(10) and C-terminus Phe(157) with PCR site-directed mutagenesis.	Aspartic Acid	226-229	tumor necrosis factor	Homo sapiens	106-115
7798197-3	1994	The substrate specificity of granzyme B, requiring an aspartic acid residue at site P1, is unique among eukaryotic serine proteases and is shared with only one other known eukaryotic protease, interleukin-1 beta-converting enzyme (ICE).	Aspartic Acid	54-67	granzyme B	Mus musculus	29-39
7597296-5	1995	Analysis of p53 gene showed mutation only in one case of mycosis fungoides in tumoral stage, at codon 163 of p53 gene (TAC--&gt;CAC; Tyr--&gt; Asp).	Aspartic Acid	143-146	tumor protein p53	Homo sapiens	12-15
7597296-5	1995	Analysis of p53 gene showed mutation only in one case of mycosis fungoides in tumoral stage, at codon 163 of p53 gene (TAC--&gt;CAC; Tyr--&gt; Asp).	Aspartic Acid	143-146	tumor protein p53	Homo sapiens	109-112
7993900-2	1994	Site-directed mutagenesis and high-resolution two-dimensional (2D) proton nuclear magnetic resonance (NMR) were used to probe the structural and functional roles of a highly conserved residue, Asp-49, in the interfacial catalysis by bovine pancreatic phospholipase A2 (PLA2, overexpressed in Escherichia coli).	Aspartic Acid	193-196	LOC104974671	Bos taurus	251-267
7803385-3	1994	CAII variants with a His ligand substituted with Cys, Asp, or Glu bind zinc only approximately 10-fold better than a His2 zinc polyhedron in CAII.	Aspartic Acid	54-57	carbonic anhydrase 2	Homo sapiens	0-4
7806521-8	1994	In the presence of 0.5 M NH4Cl, which enhances the binding of Asp-tRNA by EF1 alpha, hDRS-bound Asp-tRNA can be transferred directly to EF1 alpha.	Aspartic Acid	62-65	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	74-83
7806521-8	1994	In the presence of 0.5 M NH4Cl, which enhances the binding of Asp-tRNA by EF1 alpha, hDRS-bound Asp-tRNA can be transferred directly to EF1 alpha.	Aspartic Acid	62-65	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	136-145
7806521-8	1994	In the presence of 0.5 M NH4Cl, which enhances the binding of Asp-tRNA by EF1 alpha, hDRS-bound Asp-tRNA can be transferred directly to EF1 alpha.	Aspartic Acid	96-99	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	74-83
7806521-8	1994	In the presence of 0.5 M NH4Cl, which enhances the binding of Asp-tRNA by EF1 alpha, hDRS-bound Asp-tRNA can be transferred directly to EF1 alpha.	Aspartic Acid	96-99	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	136-145
7821814-1	1994	Sequence information for aspartyl beta-hydroxylase (AspH), which specifically hydroxylates one Asp or Asn residue in certain epidermal growth factor (EGF)-like domains of a number of proteins, is so far only described for bovine species.	Aspartic Acid	52-55	aspartate beta-hydroxylase	Bos taurus	25-50
7993900-2	1994	Site-directed mutagenesis and high-resolution two-dimensional (2D) proton nuclear magnetic resonance (NMR) were used to probe the structural and functional roles of a highly conserved residue, Asp-49, in the interfacial catalysis by bovine pancreatic phospholipase A2 (PLA2, overexpressed in Escherichia coli).	Aspartic Acid	193-196	LOC104974671	Bos taurus	269-273
7981216-3	1994	In this study, a lysine residue, conserved within transmembrane domain 3 (TM3) of the ETA and ETB receptor subtypes, is implicated in agonist and antagonist binding by its analogous position within TM3 to a binding site aspartate residue conserved within bioactive amine receptors.	Aspartic Acid	220-229	endothelin receptor type A	Homo sapiens	86-89
7993900-4	1994	The Asp-49 of PLA2 was changed to Asn, Glu, Gln, Lys, and Ala; the resulting mutants are named D49N, D49E, D49Q, D49K, and D49A, respectively.	Aspartic Acid	4-7	LOC104974671	Bos taurus	14-18
7993900-10	1994	This demonstrates the functional importance of Asp-49 in the catalytic mechanism of PLA2, presumably by helping to bind and properly orient Ca2+.	Aspartic Acid	47-50	LOC104974671	Bos taurus	84-88
9098450-5	1994	When DQA1-DQB1 genotypes were analysed for presence of Arg 52 (DQ alpha) and absence of Asp 57 (DQ beta), genotypes SS/SS were found significantly increased in diabetics.	Aspartic Acid	88-91	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	10-14
7871971-6	1994	After the administration of bestatin, an inhibitor of leucine aminopeptidase, for 9 months, the urinary ASP concentration of children with DMD increased markedly.	Aspartic Acid	104-107	carboxypeptidase Q	Homo sapiens	62-76
7998988-7	1994	Alignment with subtilisin-like serine peptidases identified Asp44, His264 and Ser449 as the catalytic triad, thus defining an extra domain of approximately 200 amino acids between the catalytic Asp and His in TPP II as compared with other subtilases.	Aspartic Acid	60-63	tripeptidyl peptidase II	Mus musculus	209-215
7881424-2	1994	All the analyzed patients are found to carry a nucleotide substitution of A or T for G654 in their gelsolin gene, which at the protein level results in the conversion of the 187 amino acid residue, aspartic acid, to asparagine or tyrosine, respectively.	Aspartic Acid	198-211	gelsolin	Homo sapiens	99-107
7813998-3	1994	A close relationship was found between age at death and the extent of aspartic acid racemization in osteocalcin, the most abundant noncollagenous protein of the organic bone matrix.	Aspartic Acid	70-83	bone gamma-carboxyglutamate protein	Homo sapiens	100-111
7813998-5	1994	Thus, the extent of aspartic acid racemization in bone osteocalcin is a measure of the age of the peptide and hence of the entire organism.	Aspartic Acid	20-33	bone gamma-carboxyglutamate protein	Homo sapiens	55-66
7813998-6	1994	The relationship between age at death and the extent of aspartic acid racemization in purified bone osteocalcin appears to be close enough to serve as a basis for determination of age at death in forensic medicine.	Aspartic Acid	56-69	bone gamma-carboxyglutamate protein	Homo sapiens	100-111
7537125-7	1994	External calcium ion and temperature dependence of adhesion together with the observation that RGD (Arg, Gly, Asp)--containing peptide blocked cell binding to FN suggests that FC epsilon RI crosslinking-induced adhesion potentiation involves an integrin type receptor on cell surface.	Aspartic Acid	110-113	fibronectin 1	Mus musculus	159-161
7734331-5	1994	An increase in the dose of cocaine from 60 to 90 or 120 mg/kg produced more extensive and severe periportal and linking portal damage and elevated plasma aspartate (AST) and alanine (ALT) aminotransferases in a dose dependent manner.	Aspartic Acid	154-163	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	165-168
7537125-7	1994	External calcium ion and temperature dependence of adhesion together with the observation that RGD (Arg, Gly, Asp)--containing peptide blocked cell binding to FN suggests that FC epsilon RI crosslinking-induced adhesion potentiation involves an integrin type receptor on cell surface.	Aspartic Acid	110-113	Fc receptor, IgE, high affinity I, alpha polypeptide	Mus musculus	176-189
7969135-3	1994	The carboxyl-terminal domains of Cln2 and the other G1 cyclins contain sequences rich in Pro, Glu (and Asp), Ser, and Thr (so-called PEST motifs) that have been postulated to make up the signals that are responsible for the rapid degradation of these and other unstable proteins.	Aspartic Acid	103-106	cyclin CLN2	Saccharomyces cerevisiae S288C	33-37
7872685-3	1994	The mutation from GGT (glycine) to GAT (aspartic acid) was the most frequent mutation in the tumor xenografts (64.7%, 11/17) as well as in the primary human neoplasms (64.7%, 11/17).	Aspartic Acid	40-53	glycine-N-acyltransferase	Homo sapiens	35-38
7538848-1	1994	Alanine-scanning mutagenesis on human growth hormone (hGH) identified 5 primary determinants (Arg 8, Asn 12, Arg 16, Asp 112, and Asp 116) for binding to a monoclonal antibody (MAb 3) (Jin L, Fendly BM, Wells JA, 1992, J Mol Biol 226:851-865).	Aspartic Acid	117-120	growth hormone 1	Homo sapiens	38-52
7538848-1	1994	Alanine-scanning mutagenesis on human growth hormone (hGH) identified 5 primary determinants (Arg 8, Asn 12, Arg 16, Asp 112, and Asp 116) for binding to a monoclonal antibody (MAb 3) (Jin L, Fendly BM, Wells JA, 1992, J Mol Biol 226:851-865).	Aspartic Acid	130-133	growth hormone 1	Homo sapiens	38-52
7756983-11	1994	In PPACK-thrombin, the side chain of Asp 189 and the segment Arg 221A-Gly 223 move to provide space for the inhibitor, whereas in hirugen-thrombin, the Ala 190-Gly 197 movement expands the active site region.	Aspartic Acid	37-40	coagulation factor II, thrombin	Homo sapiens	9-17
7846152-1	1994	Aspartate kinase (AK) and homoserine dehydrogenase (HSDH) are enzymes in the aspartate-derived amino acid biosynthetic pathway.	Aspartic Acid	77-86	bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic	Zea mays	0-50
7659918-3	1994	Since the classic demonstration by McDevitt and colleagues that DQ beta chain aspartate at position 57 was protective against the development of the disease, many populations have been surveyed to study the association between the incidence Type I diabetes and determined frequencies of DR and DQ haplotypes.	Aspartic Acid	78-87	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	64-71
7961906-1	1994	An ion-counterion interaction between the lysine of the NKXD motif in the GTPase domain and an aspartate in the inserted helical domain of alpha subunits of heterotrimeric G proteins, Lys-278 and Asp-158, respectively, of Gs alpha is shown to be essential for activation by AlF4- and partially so for interaction with beta gamma dimers and activation by GTP and receptor.	Aspartic Acid	95-104	GNAS complex locus	Homo sapiens	222-230
7961906-1	1994	An ion-counterion interaction between the lysine of the NKXD motif in the GTPase domain and an aspartate in the inserted helical domain of alpha subunits of heterotrimeric G proteins, Lys-278 and Asp-158, respectively, of Gs alpha is shown to be essential for activation by AlF4- and partially so for interaction with beta gamma dimers and activation by GTP and receptor.	Aspartic Acid	196-199	GNAS complex locus	Homo sapiens	222-230
7961923-2	1994	Sequence alignment of each ACE domain with other zinc metalloproteases, indicates a glutamate residues which putatively constitutes the third zinc ligand and an aspartate residue which may form an indirect zinc interaction.	Aspartic Acid	161-170	angiotensin I converting enzyme	Homo sapiens	27-30
7961923-3	1994	We investigated the functional roles of the glutamate and aspartate residues in the ACE C domain (Glu987 and Asp991) using a cDNA encoding an inactive N domain.	Aspartic Acid	58-67	angiotensin I converting enzyme	Homo sapiens	84-87
7961941-2	1994	We have mutated the aspartate residue in the putative second transmembrane spanning domain of the alpha 2A-adrenergic receptor (alpha 2AAR) to the non-negatively charged asparagine (D79N) and glutamine (D79Q) and the negatively charged glutamate (D79E) residue in an effort to better characterize the role of this residue, highly conserved among G-protein-coupled receptors, in Na+ regulation of ligand binding and in receptor G-protein coupling.	Aspartic Acid	20-29	adrenergic receptor, alpha 2a	Mus musculus	98-126
7961941-2	1994	We have mutated the aspartate residue in the putative second transmembrane spanning domain of the alpha 2A-adrenergic receptor (alpha 2AAR) to the non-negatively charged asparagine (D79N) and glutamine (D79Q) and the negatively charged glutamate (D79E) residue in an effort to better characterize the role of this residue, highly conserved among G-protein-coupled receptors, in Na+ regulation of ligand binding and in receptor G-protein coupling.	Aspartic Acid	20-29	adrenergic receptor, alpha 2a	Mus musculus	128-138
7962000-7	1994	Replacement of both of these Glu residues with Asp produced active Smr.	Aspartic Acid	47-50	LY6/PLAUR domain containing 4	Homo sapiens	67-70
7881050-0	1994	Modulation of striatal aspartate and dynorphin B release by cholecystokinin (CCK-8) studied in vivo with microdialysis.	Aspartic Acid	23-32	cholecystokinin	Rattus norvegicus	60-75
7881050-0	1994	Modulation of striatal aspartate and dynorphin B release by cholecystokinin (CCK-8) studied in vivo with microdialysis.	Aspartic Acid	23-32	cholecystokinin	Rattus norvegicus	77-80
7881050-1	1994	Sulphated cholecystokinin-8 (CCK-8) given into the neostriatum of the rat by in vivo microdialysis produced a concentration-dependent (1-100 microM) increase in extracellular aspartate (Asp) and dynorphin B (Dyn B), but not in glutamate, GABA or dopamine levels.	Aspartic Acid	175-184	cholecystokinin	Rattus norvegicus	10-25
7881050-1	1994	Sulphated cholecystokinin-8 (CCK-8) given into the neostriatum of the rat by in vivo microdialysis produced a concentration-dependent (1-100 microM) increase in extracellular aspartate (Asp) and dynorphin B (Dyn B), but not in glutamate, GABA or dopamine levels.	Aspartic Acid	175-184	cholecystokinin	Rattus norvegicus	29-32
7881050-1	1994	Sulphated cholecystokinin-8 (CCK-8) given into the neostriatum of the rat by in vivo microdialysis produced a concentration-dependent (1-100 microM) increase in extracellular aspartate (Asp) and dynorphin B (Dyn B), but not in glutamate, GABA or dopamine levels.	Aspartic Acid	186-189	cholecystokinin	Rattus norvegicus	10-25
7881050-1	1994	Sulphated cholecystokinin-8 (CCK-8) given into the neostriatum of the rat by in vivo microdialysis produced a concentration-dependent (1-100 microM) increase in extracellular aspartate (Asp) and dynorphin B (Dyn B), but not in glutamate, GABA or dopamine levels.	Aspartic Acid	186-189	cholecystokinin	Rattus norvegicus	29-32
7881050-2	1994	The increase in Asp levels produced by 10 microM CCK-8 was approximately 10 fold and was inhibited (approximately 50%) by the CCKB antagonist L-365,260 (20 mg kg-1, i.p.	Aspartic Acid	16-19	cholecystokinin	Rattus norvegicus	49-52
7881050-5	1994	Thus, CCK exerts modulatory effects in the basal ganglia, possibly by interacting with local neostriatal neurones releasing Asp, and with Dyn B-containing neurones projecting to the pars reticulata of the substantia nigra.	Aspartic Acid	124-127	cholecystokinin	Rattus norvegicus	6-9
7947682-4	1994	While evolutionarily divergent, iron binding by all described transferrin lobes is accomplished by a remarkably similar repertoire of residues, including two Tyr, one His, and one Asp, as well as a synergestic bicarbonate anion.	Aspartic Acid	180-183	transferrin	Homo sapiens	62-73
7811760-0	1994	Charge state specific facile gas-phase cleavage of Asp 75-Met 76 peptide bond in the alpha-chain of human apohemoglobin probed by electrospray ionization mass spectrometry.	Aspartic Acid	51-54	Fc gamma receptor and transporter	Homo sapiens	85-96
7957083-1	1994	Previous analysis of the amino acid sequence of Skn7p, the product of the yeast SKN7 gene, revealed a potential "receiver motif" homologous to that found in bacterial response regulators (signal-transducing effector proteins regulated by phosphorylation at a conserved aspartate residue corresponding to position D427 in Skn7p).	Aspartic Acid	269-278	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	48-53
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Aspartic Acid	317-330	major histocompatibility complex, class II, DR beta 1	Homo sapiens	26-30
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Aspartic Acid	317-330	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	46-50
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Aspartic Acid	317-330	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	56-60
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Aspartic Acid	332-335	major histocompatibility complex, class II, DR beta 1	Homo sapiens	26-30
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Aspartic Acid	332-335	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	46-50
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Aspartic Acid	332-335	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	56-60
7821177-6	1994	Alleles DQB1*0601 and 0603, both carrying Asp at position 57 of the beta-chain, and DQA1*0103, encoding a non-Arg 52 alpha-chain, were significantly decreased among the IDDM patients.	Aspartic Acid	42-45	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	8-12
7821177-7	1994	The presence of four susceptibility residues (two DQA1 Arg 52+ and two DQB1 Asp 57-) conferred the highest relative risk at 20.2.	Aspartic Acid	76-79	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	71-75
7821177-8	1994	On the other hand, homozygous genotypes for DQA1 non-Arg 52 and DQB1 Asp 57 were found only in the control group.	Aspartic Acid	69-72	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	64-68
7957083-1	1994	Previous analysis of the amino acid sequence of Skn7p, the product of the yeast SKN7 gene, revealed a potential "receiver motif" homologous to that found in bacterial response regulators (signal-transducing effector proteins regulated by phosphorylation at a conserved aspartate residue corresponding to position D427 in Skn7p).	Aspartic Acid	269-278	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	80-84
7957083-1	1994	Previous analysis of the amino acid sequence of Skn7p, the product of the yeast SKN7 gene, revealed a potential "receiver motif" homologous to that found in bacterial response regulators (signal-transducing effector proteins regulated by phosphorylation at a conserved aspartate residue corresponding to position D427 in Skn7p).	Aspartic Acid	269-278	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	321-326
7957084-3	1994	Among such suppressors, arcB and barA are of particular interest because these gene products are unique in the sense that they contain both an autophosphorylated histidine site (or transmitter module) and a phospho-accepting aspartate site (or receiver module) in their primary amino acid sequences.	Aspartic Acid	225-234	hypothetical protein	Escherichia coli	24-28
7868373-8	1994	At the segments analyzed, they differ solely at position 57, which is GAT (aspartic acid) in DRB1*1402 and AGC (serine) in DRB1*1413.	Aspartic Acid	75-88	major histocompatibility complex, class II, DR beta 1	Homo sapiens	93-97
7957584-0	1994	Mutation of aspartate 82 of the human C5a receptor abolishes the secretory response to human C5a in transfected rat basophilic leukemia cells.	Aspartic Acid	12-21	complement C5a receptor 1	Homo sapiens	38-50
7957584-0	1994	Mutation of aspartate 82 of the human C5a receptor abolishes the secretory response to human C5a in transfected rat basophilic leukemia cells.	Aspartic Acid	12-21	complement C5a receptor 1	Homo sapiens	38-41
7957584-2	1994	The receptor for human C5a is a member of the rhodopsin superfamily of G protein-coupled receptors and contains an aspartate residue (Asp82) within the putative second transmembrane domain conserved in all other G protein-linked receptors.	Aspartic Acid	115-124	complement C5a receptor 1	Homo sapiens	23-26
7957584-2	1994	The receptor for human C5a is a member of the rhodopsin superfamily of G protein-coupled receptors and contains an aspartate residue (Asp82) within the putative second transmembrane domain conserved in all other G protein-linked receptors.	Aspartic Acid	115-124	rhodopsin	Homo sapiens	46-55
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Aspartic Acid	87-90	angiotensinogen	Homo sapiens	71-85
7896748-6	1994	The most notable feature of porcine ATIII was that it possesses only three carbohydrate chains, at Asn136, 156, and 193, whereas other mammalian ATIIIs have four, additional chain being at Asn97; this is replaced by Asp in porcine ATIII.	Aspartic Acid	216-219	serpin family C member 1	Homo sapiens	36-41
21559673-9	1994	AOM-induced G to A transitions were observed at the second nucleotide of 12th codon of K-ras substituting amino acid asp with wild-type gly.	Aspartic Acid	117-120	KRAS proto-oncogene, GTPase	Rattus norvegicus	87-92
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Aspartic Acid	87-90	angiotensinogen	Homo sapiens	71-84
7761990-1	1994	Amyloid beta protein (A beta) in neuritic plaques of Alzheimer"s disease has been found to be racemized and/or isomerized at their Asp residues.	Aspartic Acid	131-134	amyloid beta precursor protein	Homo sapiens	0-12
7883862-0	1994	Cystic fibrosis-related diabetes is associated with HLA DQB1 alleles encoding Asp-57- molecules.	Aspartic Acid	78-81	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	52-60
7853017-6	1994	Riluzole, which blocks the release of glutamate and aspartate from nerve terminals, prevents (10(-7) M) the neuronal degeneration produced by 20 pM of gp120 in cortical cell cultures.	Aspartic Acid	52-61	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	151-156
7703854-1	1994	To probe the role of the Asp-99 ... His-48 pair in phospholipase A2 (PLA2) catalysis, the X-ray structure and kinetic characterization of the mutant Asp-99--&gt;Asn-99 (D99N) of bovine pancreatic PLA2 was undertaken.	Aspartic Acid	25-28	LOC104974671	Bos taurus	69-73
7823029-2	1994	For aspartate, the unbalanced position of its amino group between a pair of carboxylates allows its occasional biorecognition as a beta-rather than as an alpha-amino acid, whereas for proline and its homologs, their cyclic arrangement may allow the imino group, without its being replicated, to be sensed analogously as falling at either of two distances from the single carboxylate group.	Aspartic Acid	4-13	amyloid beta precursor protein	Homo sapiens	129-135
7535613-6	1994	In the resulting PSA structure, the catalytic triad, involving residues His 57, Asp 102, and Ser 195, and hydrophobic and electrostatic interactions typical of serine proteases were extremely well conserved.	Aspartic Acid	80-83	kallikrein related peptidase 3	Homo sapiens	17-20
7878657-2	1994	The two subtypes differ for a single amino acid substitution from Asp (HLA-B*4402) to Leu (HLA-B*4403) in position 156 of the alpha 2 domain, causing strong alloreactivity in vivo.	Aspartic Acid	66-69	major histocompatibility complex, class I, B	Homo sapiens	71-76
7761990-1	1994	Amyloid beta protein (A beta) in neuritic plaques of Alzheimer"s disease has been found to be racemized and/or isomerized at their Asp residues.	Aspartic Acid	131-134	amyloid beta precursor protein	Homo sapiens	22-28
7929297-4	1994	Proteolytic fragments (5-6 kDa) of ec-eIF-5A (the precursor form of eIF-5A produced in Escherichia coli by expression of the human eIF-5A cDNA) generated by specific cleavage by endoproteinases Arg-C, Asp-N, or Glu-C, did not act as substrates for deoxyhypusine synthesis.	Aspartic Acid	201-204	eukaryotic translation initiation factor 5A	Homo sapiens	38-44
7523411-6	1994	This repeat contains the arginine-glycine-aspartic acid (RGD) tripeptide that has been shown to serve as a binding site in tenascin for alpha v-integrins.	Aspartic Acid	42-55	tenascin C	Homo sapiens	123-131
7980563-5	1994	In both human and mouse IA-2, several substitutions were found in the highly conserved regions including an Ala to Asp substitution in the core sequence.	Aspartic Acid	115-118	protein tyrosine phosphatase, receptor type, N	Mus musculus	24-28
7957181-3	1994	A complete antagonist and a series of low-efficacy agonist variants of human interleukin-4 could be generated by introducing combinations of two or three negatively charged aspartic acid residues in this site at positions 121, 124, and 125.	Aspartic Acid	173-186	interleukin 4	Homo sapiens	77-90
7923176-11	1994	p53 allelic amino acid variation with sequences coding for aspartic acid or asparagine was present in codon 61 in the variable region of exon 4 in both HCCs and nonneoplastic tissues of ground squirrels.	Aspartic Acid	59-72	tumor protein p53	Homo sapiens	0-3
7929297-4	1994	Proteolytic fragments (5-6 kDa) of ec-eIF-5A (the precursor form of eIF-5A produced in Escherichia coli by expression of the human eIF-5A cDNA) generated by specific cleavage by endoproteinases Arg-C, Asp-N, or Glu-C, did not act as substrates for deoxyhypusine synthesis.	Aspartic Acid	201-204	eukaryotic translation initiation factor 5A	Homo sapiens	68-74
7929297-4	1994	Proteolytic fragments (5-6 kDa) of ec-eIF-5A (the precursor form of eIF-5A produced in Escherichia coli by expression of the human eIF-5A cDNA) generated by specific cleavage by endoproteinases Arg-C, Asp-N, or Glu-C, did not act as substrates for deoxyhypusine synthesis.	Aspartic Acid	201-204	eukaryotic translation initiation factor 5A	Homo sapiens	68-74
7937855-3	1994	nmt1-181 encodes a mutant enzyme with a Gly451--&gt;Asp substitution.	Aspartic Acid	52-55	glycylpeptide N-tetradecanoyltransferase NMT1	Saccharomyces cerevisiae S288C	0-4
7918609-0	1994	Characterization of two new human apolipoprotein A-I variants: apolipoprotein A-I Tsushima (Trp-108--&gt;Arg) and A-I Hita (Ala-95--&gt;Asp).	Aspartic Acid	136-139	apolipoprotein A1	Homo sapiens	34-52
7918609-4	1994	The second case, apo A-I Hita, revealed a residue 95 missense mutation (GCC--&gt;GAC, Ala--&gt;Asp) in exon 4.	Aspartic Acid	95-98	apolipoprotein A1	Homo sapiens	17-24
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Aspartic Acid	57-60	interleukin 1 beta	Homo sapiens	101-119
7929169-1	1994	The suggestion that acidic residues in the hydrophobic NH2-terminal domains of Mel permease (Asp-31 in helix I, Asp-51 and Asp-55 in helix II, Asp-120 in helix IV) may be essential components of a coordination network involved in cation recognition (Pourcher, T., Zani, M.L., and Leblanc, G. (1993) J. Biol.	Aspartic Acid	93-96	macrolide efflux protein	Escherichia coli	79-82
7929169-1	1994	The suggestion that acidic residues in the hydrophobic NH2-terminal domains of Mel permease (Asp-31 in helix I, Asp-51 and Asp-55 in helix II, Asp-120 in helix IV) may be essential components of a coordination network involved in cation recognition (Pourcher, T., Zani, M.L., and Leblanc, G. (1993) J. Biol.	Aspartic Acid	112-115	macrolide efflux protein	Escherichia coli	79-82
7929169-1	1994	The suggestion that acidic residues in the hydrophobic NH2-terminal domains of Mel permease (Asp-31 in helix I, Asp-51 and Asp-55 in helix II, Asp-120 in helix IV) may be essential components of a coordination network involved in cation recognition (Pourcher, T., Zani, M.L., and Leblanc, G. (1993) J. Biol.	Aspartic Acid	112-115	macrolide efflux protein	Escherichia coli	79-82
7929169-1	1994	The suggestion that acidic residues in the hydrophobic NH2-terminal domains of Mel permease (Asp-31 in helix I, Asp-51 and Asp-55 in helix II, Asp-120 in helix IV) may be essential components of a coordination network involved in cation recognition (Pourcher, T., Zani, M.L., and Leblanc, G. (1993) J. Biol.	Aspartic Acid	112-115	macrolide efflux protein	Escherichia coli	79-82
7865680-8	1994	These observations also demonstrate that the fibrinogen alpha-chain arginine-glycine-aspartic acid-phenylalanine and arginine-glycine-aspartic acid-serine sequences are not necessary or sufficient to mediate the adhesion of resting or stimulated platelets in plasma to fibrinogen.	Aspartic Acid	85-98	fibrinogen beta chain	Homo sapiens	45-55
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Aspartic Acid	57-60	interleukin 1 beta	Homo sapiens	121-130
7702747-5	1994	The C-terminal segment includes the active-site residues Asp-116, Gln-117, and Ser-118; Gln-117 in particular has been shown to be important in affecting the ribonucleolytic activity of angiogenin.	Aspartic Acid	57-60	angiogenin	Homo sapiens	186-196
7931281-4	1994	When tissue was preincubated with L-AP3, the effects of L-Glu, L-Asp, or D-Asp were blocked (IC50 values between 65 and 210 microM).	Aspartic Acid	63-68	leucine aminopeptidase 3	Homo sapiens	34-39
7530316-5	1994	The receptors involved in this "sandwich" adherence belong to the integrin family since the interaction was inhibited by peptides containing the amino acid sequence arginine-glycine-aspartic acid (RGD) and the tetrapeptide RGDS (but not the peptide RGES) was inhibitory.	Aspartic Acid	182-195	ral guanine nucleotide dissociation stimulator	Homo sapiens	223-227
8083199-6	1994	The data also show that one source of the large enhancement of kcat/Km for the mutant containing Asp-198 in human carbonic anhydrase III is the presence of both Asp-198 and Lys-64; when Lys-64 was replaced with Ala, a reduction of catalytic activity was observed.	Aspartic Acid	97-100	carbonic anhydrase 3	Homo sapiens	114-136
7983809-3	1994	In Caucasians, this susceptibility is thought to be determined by DQA1 and DQB1 genes including the presence of arginine at position 52 of the DQ alpha chain and the absence of aspartic acid at position 57 of the DQ beta chain.	Aspartic Acid	177-190	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	75-79
8091650-7	1994	When the P6 aspartic acid was changed to asparagine, lysine, or serine, NS3-mediated cleavage occurred.	Aspartic Acid	12-25	KRAS proto-oncogene, GTPase	Homo sapiens	72-75
8091686-8	1994	While influencing intracellular accumulation, the Thr-10--&gt;Ser and His-13--&gt;Asp mutations in tsG VP6 are probably not directly involved in the interaction of VP6 with VP2, as VP6 deletion mutants lacking residues 10 and 13 retain the ability to bind VP2 in vitro.	Aspartic Acid	82-85	twisted gastrulation BMP signaling modulator 1	Homo sapiens	99-102
8089117-2	1994	An apparently unique enzyme, designated protein NH2-terminal asparagine deamidase (PNAD), that specifically converts NH2-terminal asparagine residues of peptide and protein substrates to aspartic acid, has been isolated to homogeneity from porcine liver by an eight-step procedure.	Aspartic Acid	187-200	N-terminal asparagine amidase	Homo sapiens	40-81
8089117-2	1994	An apparently unique enzyme, designated protein NH2-terminal asparagine deamidase (PNAD), that specifically converts NH2-terminal asparagine residues of peptide and protein substrates to aspartic acid, has been isolated to homogeneity from porcine liver by an eight-step procedure.	Aspartic Acid	187-200	N-terminal asparagine amidase	Homo sapiens	83-87
8089117-10	1994	Conversion of the resulting NH2-terminal asparagine to aspartic acid by PNAD would render the protein susceptible to arginylation, polyubiquitinylation and degradation as specified by the N-end rule.	Aspartic Acid	55-68	N-terminal asparagine amidase	Homo sapiens	72-76
8084599-3	1994	Removal of the CKII site either by substitution of S111/112 by nonphosphorylatable amino acid residues, or mutation of the Asp-Asp-Glu113/115 CKII recognition sequence to Asn-Asn-Gln, resulted in nuclear import rates less than 4% wild type, demonstrating that the CKII site was responsible for the enhancement of nuclear import conferred by T-ag amino acids 111-125.	Aspartic Acid	123-126	casein kinase 2 alpha 1	Homo sapiens	15-19
8084599-3	1994	Removal of the CKII site either by substitution of S111/112 by nonphosphorylatable amino acid residues, or mutation of the Asp-Asp-Glu113/115 CKII recognition sequence to Asn-Asn-Gln, resulted in nuclear import rates less than 4% wild type, demonstrating that the CKII site was responsible for the enhancement of nuclear import conferred by T-ag amino acids 111-125.	Aspartic Acid	127-130	casein kinase 2 alpha 1	Homo sapiens	15-19
7878634-4	1994	Based on the hypothesis that such an additional regulatory element should be located near the thrombin cleavage site and should include negatively charged amino acids to ascertain calcium binding, we studied whether Glu and Asp in positions P7 and P6 relative to the thrombin cleavage site together with Asp in P3 are involved in formation of such a regulatory element.	Aspartic Acid	224-227	solute carrier family 10 member 7	Homo sapiens	241-250
8083199-6	1994	The data also show that one source of the large enhancement of kcat/Km for the mutant containing Asp-198 in human carbonic anhydrase III is the presence of both Asp-198 and Lys-64; when Lys-64 was replaced with Ala, a reduction of catalytic activity was observed.	Aspartic Acid	161-164	carbonic anhydrase 3	Homo sapiens	114-136
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Aspartic Acid	74-87	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	46-50
8078584-8	1994	We found that a single amino-acid change within the putative transmembrane domain M2, aspartate (D) in IRK1 to the corresponding asparagine (N) in ROMK1, controls the gating phenotype.	Aspartic Acid	86-95	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	103-107
8078584-8	1994	We found that a single amino-acid change within the putative transmembrane domain M2, aspartate (D) in IRK1 to the corresponding asparagine (N) in ROMK1, controls the gating phenotype.	Aspartic Acid	86-95	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	147-152
7915326-1	1994	Aminopeptidase A (APA) is a highly selective peptidase, which cleaves the N-terminal Glu or Asp residues of biologically active peptides, and has therefore been proposed to be involved in angiotensin II and CCK8 metabolism.	Aspartic Acid	92-95	glutamyl aminopeptidase	Homo sapiens	0-16
7915326-1	1994	Aminopeptidase A (APA) is a highly selective peptidase, which cleaves the N-terminal Glu or Asp residues of biologically active peptides, and has therefore been proposed to be involved in angiotensin II and CCK8 metabolism.	Aspartic Acid	92-95	glutamyl aminopeptidase	Homo sapiens	18-21
7915326-1	1994	Aminopeptidase A (APA) is a highly selective peptidase, which cleaves the N-terminal Glu or Asp residues of biologically active peptides, and has therefore been proposed to be involved in angiotensin II and CCK8 metabolism.	Aspartic Acid	92-95	angiotensinogen	Homo sapiens	188-202
8090778-2	1994	By site-directed mutagenesis, we have demonstrated that invariant residues Asp-261 and Glu-262 of the nucleic acid-binding TFIIS Zn ribbon are critical for stimulation of both elongation and RNA cleavage activities of RNA polymerase II.	Aspartic Acid	75-78	transcription elongation factor A2	Homo sapiens	123-128
7811002-7	1994	Mutations were found in three of nine isolates tested; these mutations caused the following alterations in the sequence of GyrA: Asp at position 87 (Asp-87) to Asn, Asp-87 to Tyr, and Thr-83 to Ile.	Aspartic Acid	129-132	DNA gyrase subunit A	Pseudomonas aeruginosa PAO1	123-127
7849073-0	1994	Targeting glucose oxidase at aspartate and glutamate residues with organic two-electron redox mediators.	Aspartic Acid	29-38	hydroxyacid oxidase 1	Homo sapiens	10-25
7849073-3	1994	GOx was covalently derivatized using 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide and N-hydroxysulfosuccinimide to form amide bonds between the aliphatic primary amine groups on daunomycin and dopamine and carboxylate side chains of aspartate and glutamate residues.	Aspartic Acid	236-245	hydroxyacid oxidase 1	Homo sapiens	0-3
7988304-7	1994	On the other hand, the presence of two DQB1 alleles with Asp in position 57 was sufficient to confer resistance to disease irrespective of the DQA1 genotype.	Aspartic Acid	57-60	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	39-43
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Aspartic Acid	74-87	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	124-131
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Aspartic Acid	93-96	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	46-50
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Aspartic Acid	93-96	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	124-131
7520097-3	1994	Conserved within this variable region is the sequence Arg-Gly-Asp (RGD), which, in the Ad2 penton base, binds to integrins in the target cell membrane, enhancing the rate or the efficiency of infection.	Aspartic Acid	62-65	apolipoprotein E	Homo sapiens	87-90
7839351-3	1994	The shorter TAP2*01 alleles are present in 99% of diabetics and 90% of controls; these alleles may add slight, although significant and independent, susceptibility to diabetes, particularly in subjects carrying non-Asp 57 at beta DQ.	Aspartic Acid	215-218	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	12-16
8091132-2	1994	An exchange of phe195 with a tyrosine residue does not affect Tcr/CD3 membrane expression; however, exchange with aspartic acid, histidine or valine prohibit completely Tcr/CD3 membrane expression.	Aspartic Acid	114-127	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	169-172
8058766-7	1994	A synthetic peptide spanning the N-terminal thrombin receptor activation sequence was cleaved by granzyme A at the authentic thrombin cleavage site Leu-Asp-Pro-Arg-Ser.	Aspartic Acid	152-155	coagulation factor II	Mus musculus	44-52
7982101-5	1994	Instead, analysis of [3H]D-Asp uptake kinetics indicates that CORT decreased the maximum uptake rate and the Michaelis constant by 44% and 50%, respectively, in cells treated with cyanide.	Aspartic Acid	27-30	cortistatin	Rattus norvegicus	62-66
8063719-4	1994	Asp-176 in rabbit SGLT1 was replaced with asparagine and alanine residues, and the wild-type and mutant proteins were expressed in Xenopus laevis oocytes.	Aspartic Acid	0-3	solute carrier family 5 member 1	Homo sapiens	18-23
8058766-7	1994	A synthetic peptide spanning the N-terminal thrombin receptor activation sequence was cleaved by granzyme A at the authentic thrombin cleavage site Leu-Asp-Pro-Arg-Ser.	Aspartic Acid	152-155	granzyme A	Mus musculus	97-107
8060313-0	1994	A cell-binding Arg-Gly-Asp sequence is present in close proximity to the major linear antigenic region of HCV NS3.	Aspartic Acid	23-26	KRAS proto-oncogene, GTPase	Homo sapiens	110-113
8058766-7	1994	A synthetic peptide spanning the N-terminal thrombin receptor activation sequence was cleaved by granzyme A at the authentic thrombin cleavage site Leu-Asp-Pro-Arg-Ser.	Aspartic Acid	152-155	coagulation factor II	Mus musculus	125-133
7914513-0	1994	A K-ras 13Gly--&gt;Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer.	Aspartic Acid	19-22	KRAS proto-oncogene, GTPase	Homo sapiens	2-7
8068623-2	1994	This study presents further evidence that this process can be modulated in human adipocytes by the adipsin/acylation stimulating protein (ASP) pathway and suggests a novel function for the product of this system--ASP.	Aspartic Acid	138-141	complement factor D	Homo sapiens	99-106
8068623-3	1994	The data demonstrate the following: (1) ASP stimulates triacylglycerol synthesis within adipocytes, and this occurs to a greater extent in differentiating than undifferentiated cells (242% +/- 32% vs 168% +/- 11%, p &lt; 0.01, respectively, at an ASP concentration of 88 ng/mL; (2) ASP does not affect the Km for triacylglycerol synthesis but does substantially increase Vmax; (3) when ASP is generated in vitro through incubation of its precursor proteins under appropriate conditions, triacylglycerol synthesis increases to the same extent as when plasma-purified ASP is added to the medium; (4) human adipocytes contain mRNA for the specific serine protease adipsin and the two precursor proteins C3 and factor B required to interact for the production of ASP; and (5) the extent to which cultured differentiating adipocytes produce ASP is proportional to the degree to which they have accumulated triacylglycerol mass during differentiation (r2 = 0.7523, p &lt; 0.0005).	Aspartic Acid	40-43	complement factor D	Homo sapiens	661-668
8068623-3	1994	The data demonstrate the following: (1) ASP stimulates triacylglycerol synthesis within adipocytes, and this occurs to a greater extent in differentiating than undifferentiated cells (242% +/- 32% vs 168% +/- 11%, p &lt; 0.01, respectively, at an ASP concentration of 88 ng/mL; (2) ASP does not affect the Km for triacylglycerol synthesis but does substantially increase Vmax; (3) when ASP is generated in vitro through incubation of its precursor proteins under appropriate conditions, triacylglycerol synthesis increases to the same extent as when plasma-purified ASP is added to the medium; (4) human adipocytes contain mRNA for the specific serine protease adipsin and the two precursor proteins C3 and factor B required to interact for the production of ASP; and (5) the extent to which cultured differentiating adipocytes produce ASP is proportional to the degree to which they have accumulated triacylglycerol mass during differentiation (r2 = 0.7523, p &lt; 0.0005).	Aspartic Acid	40-43	complement C3	Homo sapiens	700-715
7800847-3	1994	However, sequencing of chicken PP using modem automated gas-phase sequencing technology has revealed that the original primary structure is incorrect in that residue 22 is Asn and that residue 23 is Asp.	Aspartic Acid	199-202	pancreatic hormone	Gallus gallus	31-33
8051171-6	1994	Comparison between the structures of Alpha-class GST suggests that tyrosine at residue 108 and/or aspartate at residue 208 is responsible for the high aflatoxin B1 detoxication capacity of Yc2.	Aspartic Acid	98-107	glutathione S-transferase alpha 3	Rattus norvegicus	189-192
7984627-1	1994	The stability mutant Tyr-26--&gt;Asp was studied in the Cro protein from bacteriophage lambda using free energy molecular dynamics simulations.	Aspartic Acid	33-36	cro	Escherichia virus Lambda	56-59
8051088-4	1994	The purified venom mucin comprised about 85% carbohydrate and 15% protein and was rich in Thr, Ser, Pro, Gly, Glu, Asp, and Ala.	Aspartic Acid	115-118	LOC100508689	Homo sapiens	19-24
8074190-8	1994	Single channel conductance fluctuations measured using pipettes containing potassium aspartate were distributed mainly around three peaks, at 21, 39, and 60 pS, suggesting the presence of channels formed by connexin 43.	Aspartic Acid	75-94	gap junction protein, beta 1	Mus musculus	207-218
7527054-4	1994	Fibronectin contains at least three distinct peptide sequences that are active sites for alpha 4 beta 1 binding, two homologous sequences Leu-Asp-Val-Pro (LDVP) and Ile-Asp-Ala-Pro (IDAP), and a third related to Arg-Gly-Asp (RGD).	Aspartic Acid	142-145	fibronectin 1	Homo sapiens	0-11
8027545-10	1994	However, substituting leucine for aspartate at P4 transformed DR1 and DR12 ligands into excellent DR17 binders.	Aspartic Acid	34-43	down-regulator of transcription 1	Homo sapiens	62-65
8027545-11	1994	This conversion, enabled by a single amino acid substitution, emphasizes the importance of aspartate as the DR17-specific contact site and suggests that terminal contact residues are shared among DR1, DR12, and DR17 ligands.	Aspartic Acid	91-100	down-regulator of transcription 1	Homo sapiens	108-111
8036014-2	1994	It contains a functional gly-arg-gly-asp-ser (GRGDS) integrin binding domain (Oldberg et al., 1986), promotes the adhesion of a variety of cell types (Somerman et al., 1989; Brown et al., 1992) and is a ligand for the vitronectin binding integrin alpha v beta 3 (Miyauchi et al., 1991).	Aspartic Acid	37-40	vitronectin	Homo sapiens	218-229
8036014-2	1994	It contains a functional gly-arg-gly-asp-ser (GRGDS) integrin binding domain (Oldberg et al., 1986), promotes the adhesion of a variety of cell types (Somerman et al., 1989; Brown et al., 1992) and is a ligand for the vitronectin binding integrin alpha v beta 3 (Miyauchi et al., 1991).	Aspartic Acid	37-40	integrin subunit alpha V	Homo sapiens	238-261
7980121-6	1994	Those containing a phosphorylated terminal residue inhibited dissolution to a greater extent than the native statherin fragment having aspartate as the N-terminal residue.	Aspartic Acid	135-144	statherin	Homo sapiens	109-118
7525948-10	1994	When the anionic amino acids glutamate and aspartate were used to replace extracellular Cl-, the permeability ratios were calculated to be PGlut/PCl = 0.20 and PAsp/PCl = 0.17.	Aspartic Acid	43-52	PHD finger protein 1	Homo sapiens	145-148
7525948-10	1994	When the anionic amino acids glutamate and aspartate were used to replace extracellular Cl-, the permeability ratios were calculated to be PGlut/PCl = 0.20 and PAsp/PCl = 0.17.	Aspartic Acid	43-52	carboxypeptidase B1	Homo sapiens	160-164
7525948-10	1994	When the anionic amino acids glutamate and aspartate were used to replace extracellular Cl-, the permeability ratios were calculated to be PGlut/PCl = 0.20 and PAsp/PCl = 0.17.	Aspartic Acid	43-52	PHD finger protein 1	Homo sapiens	165-168
7984627-3	1994	Moreover, the aspartic acid in the mutant was found to form a capping interaction with the amino terminus of the third alpha-helix of Cro.	Aspartic Acid	14-27	cro	Escherichia virus Lambda	134-137
7518445-1	1994	PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets.	Aspartic Acid	71-74	dual specificity phosphatase 2	Homo sapiens	0-4
7518445-1	1994	PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets.	Aspartic Acid	71-74	fibrinogen beta chain	Homo sapiens	93-103
7518462-3	1994	On an 11.5-kDa fragment of fibronectin that included the Arg-Gly-Asp (RGD) sequence, but not the synergy site, binding was reduced 50-fold.	Aspartic Acid	65-68	fibronectin 1	Homo sapiens	27-38
7518445-2	1994	The unique binding properties of PAC1 may be determined by its large size, its multivalency, and by variable region sequences, including an Arg-Tyr-Asp at residues 100A-C in H-CDR3.	Aspartic Acid	148-151	dual specificity phosphatase 2	Homo sapiens	33-37
7518445-2	1994	The unique binding properties of PAC1 may be determined by its large size, its multivalency, and by variable region sequences, including an Arg-Tyr-Asp at residues 100A-C in H-CDR3.	Aspartic Acid	148-151	CDR3	Homo sapiens	176-180
7518445-8	1994	Conversion of Asp100C to Glu by site-directed mutagenesis rendered the antibody inactive, indicating that the Arg-Tyr-Asp sequence in H-CDR3 is essential for PAC1 recognition of alpha IIb beta 3.	Aspartic Acid	14-17	dual specificity phosphatase 2	Homo sapiens	158-162
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Aspartic Acid	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
8034671-6	1994	The carboxyl-terminal sequence His-Asp-Glu-Leu (HDEL) is required for retention of ERC-55 in the ER.	Aspartic Acid	35-38	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	48-52
8034645-6	1994	Acetylation or carbamylation of the alpha-amino group of the NH2-terminal Ile-153 of VIIa resulted in the loss of binding affinity for TF; such modifications convert VIIa into a zymogen-like inactive form by destroying the salt bridge between Ile-153 and Asp-343 in VIIa.	Aspartic Acid	255-258	LOC101909187	Bos taurus	135-137
8034645-9	1994	Therefore, binding of TF with the heavy chain of VIIa may induce a conformational change that brings the alpha-amino group of Ile-153 close to the beta-carboxyl group of Asp-343 to make a stable salt bridge.	Aspartic Acid	170-173	LOC101909187	Bos taurus	22-24
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Aspartic Acid	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
8034671-6	1994	The carboxyl-terminal sequence His-Asp-Glu-Leu (HDEL) is required for retention of ERC-55 in the ER.	Aspartic Acid	35-38	reticulocalbin 2	Homo sapiens	83-89
8041731-1	1994	The residue proposed to serve as the catalytic base for phosphoryl transfer, Asp-813, of the human epidermal growth factor receptor (EGFR) was mutated to Ala, and the mutant receptor (D813A) was expressed in Chinese hamster ovary (CHO) cells.	Aspartic Acid	77-80	epidermal growth factor receptor	Homo sapiens	99-131
8034673-7	1994	Expression and analysis of site-directed mutants of CPT II showed that histidine 372, as well as aspartates 376 and 464 (all conserved throughout the carnitine/choline acyltransferase family), are essential for catalytic activity.	Aspartic Acid	97-107	carnitine palmitoyltransferase 2	Rattus norvegicus	52-58
8034673-8	1994	The data suggest that the mechanism by which CPT II effects transesterification between palmitoyl-CoA and carnitine possibly involves histidine 372 and one of these aspartate residues, interacting with the carnitine hydroxyl group, in a reaction analogous to that carried out by a histidine/aspartate/serine catalytic triad in certain other enzyme systems.	Aspartic Acid	165-174	carnitine palmitoyltransferase 2	Rattus norvegicus	45-51
8034673-8	1994	The data suggest that the mechanism by which CPT II effects transesterification between palmitoyl-CoA and carnitine possibly involves histidine 372 and one of these aspartate residues, interacting with the carnitine hydroxyl group, in a reaction analogous to that carried out by a histidine/aspartate/serine catalytic triad in certain other enzyme systems.	Aspartic Acid	291-300	carnitine palmitoyltransferase 2	Rattus norvegicus	45-51
8041731-1	1994	The residue proposed to serve as the catalytic base for phosphoryl transfer, Asp-813, of the human epidermal growth factor receptor (EGFR) was mutated to Ala, and the mutant receptor (D813A) was expressed in Chinese hamster ovary (CHO) cells.	Aspartic Acid	77-80	epidermal growth factor receptor	Homo sapiens	133-137
8041731-6	1994	These data suggest not only that Asp-813 is critical to the catalytic activity of the EGFR but also that differences may exist in the signaling properties of kinase-negative Lys-721 and kinase-negative Asp-813 EGFR mutants.	Aspartic Acid	33-36	epidermal growth factor receptor	Cricetulus griseus	86-90
8041731-6	1994	These data suggest not only that Asp-813 is critical to the catalytic activity of the EGFR but also that differences may exist in the signaling properties of kinase-negative Lys-721 and kinase-negative Asp-813 EGFR mutants.	Aspartic Acid	202-205	epidermal growth factor receptor	Cricetulus griseus	86-90
7519012-9	1994	This gave rise to the 22 kDa form attached with a GPI anchor, suggesting that GPI is covalently linked to the aspartic acid residue (Asp159) of alpha GL-PLAP.	Aspartic Acid	110-123	leucyl and cystinyl aminopeptidase	Rattus norvegicus	153-157
8002038-3	1994	The results show that those DQB1 alleles, which carry non-aspartic acid at position 57, in conjunction with DQA1 alleles carrying arginine at position 52, are strongly associated with susceptibility to type 1 diabetes.	Aspartic Acid	58-71	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	28-32
8055928-4	1994	Previous studies with Asp--&gt;Gly mutants indicated that both the P3 and the P3" Asp residues make either peptides or protein C a poor substrate for free thrombin, but thrombin interaction with thrombomodulin overcomes these inhibitory interactions.	Aspartic Acid	82-85	coagulation factor II, thrombin	Homo sapiens	155-163
8055928-6	1994	In rodents, the P3 Asp residue of the human thrombin receptor is replaced by Asn and in protein C, the P3" residue is Asn.	Aspartic Acid	19-22	coagulation factor II, thrombin	Homo sapiens	44-52
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Aspartic Acid	104-107	fibronectin 1	Mus musculus	336-347
7519012-7	1994	When a mutant alpha GL-PLAP, in which the aspartic acid residue is replaced with tryptophan at a putative cleavage/attachment site, was expressed in COS-1 cells, the 25 kDa precursor was the only form found inside the cell and retained in the endoplasmic reticulum, as judged by immunofluorescence microscopy.	Aspartic Acid	42-55	leucyl and cystinyl aminopeptidase	Rattus norvegicus	23-27
8034581-5	1994	Granzyme B that was affinity-purified with 2C5 from the nuclei of YT or human LAK cells was capable of efficiently cleaving synthetic peptide thiobenzyl ester substrates with the same specificity (peptide cleavage after aspartic acid) as granule-localized granzyme B.	Aspartic Acid	220-233	granzyme B	Homo sapiens	0-10
8037659-0	1994	The catalytic role of aspartate in the active site of glutamate dehydrogenase.	Aspartic Acid	22-31	glutamate dehydrogenase	Escherichia coli	54-77
8037659-1	1994	A putative catalytic aspartyl residue, Asp-165, in the active site of clostridial glutamate dehydrogenase has been replaced with serine by site-directed mutagenesis.	Aspartic Acid	39-42	glutamate dehydrogenase	Escherichia coli	82-105
7994452-1	1994	Exogenous angiotensin I (ANG I) was degraded to mainly des-Asp-ANG I instead of ANG II in the hypothalamic homogenate of the Sprague Dawley (SD), Wistar Kyoto (WKY), left renal artery stenosed hypertensive SD (LRAS), deoxycorticosterone acetate/salt-induced hypertensive SD (DOCA-salt) and spontaneously hypertensive rats (SHR).	Aspartic Acid	59-62	angiogenin	Rattus norvegicus	25-28
7994452-1	1994	Exogenous angiotensin I (ANG I) was degraded to mainly des-Asp-ANG I instead of ANG II in the hypothalamic homogenate of the Sprague Dawley (SD), Wistar Kyoto (WKY), left renal artery stenosed hypertensive SD (LRAS), deoxycorticosterone acetate/salt-induced hypertensive SD (DOCA-salt) and spontaneously hypertensive rats (SHR).	Aspartic Acid	59-62	angiogenin	Rattus norvegicus	63-66
8020583-9	1994	Distinction between the assembly-promoting potentials of the two arginine residues of the N-terminal doublet was considerably facilitated by a Val389--&gt;Asp substitution toward the carboxy-end of the 2B segment of the vimentin rod domain.	Aspartic Acid	155-158	vimentin	Mus musculus	220-228
7937552-0	1994	Major degradation products of basic fibroblast growth factor: detection of succinimide and iso-aspartate in place of aspartate.	Aspartic Acid	95-104	fibroblast growth factor 2	Homo sapiens	30-60
7518829-3	1994	Other mutations, such as the relatively common glycine--&gt;aspartic acid replacement at CFTR position 551 (G551D) appear to be normally processed, and therefore must cause disease through some other mechanism.	Aspartic Acid	60-73	CF transmembrane conductance regulator	Homo sapiens	89-93
7965824-0	1994	A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.	Aspartic Acid	9-18	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	110-114
7965824-2	1994	We describe the effects on channel function of changing an aspartate residue (Asp172) in a membrane-spanning alpha-helix of the murine inward rectifier, IRK1, by site-directed mutagenesis.	Aspartic Acid	59-68	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	153-157
7518568-6	1994	It has been suggested that the aspartic acid of C4A at position 1106 is involved in amide bond formation by serving as a catalytic residue for the reaction or by promoting an increased interaction with amino nucleophilic groups.	Aspartic Acid	31-44	complement C4A (Rodgers blood group)	Homo sapiens	48-51
7974465-2	1994	DQA1*0104 has a guanine in the second position of the second expressed codon, whereas DQA1*0101 and all other sequenced DQA1 alleles have an adenine in that position, changing aspartic acid to glycine.	Aspartic Acid	176-189	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	0-4
7524891-0	1994	Bioactive Arg-Gly-Asp conformations in anti-integrin GPIIb-IIIa antibodies.	Aspartic Acid	18-21	integrin subunit alpha 2b	Homo sapiens	53-58
7974465-2	1994	DQA1*0104 has a guanine in the second position of the second expressed codon, whereas DQA1*0101 and all other sequenced DQA1 alleles have an adenine in that position, changing aspartic acid to glycine.	Aspartic Acid	176-189	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	86-90
7974465-2	1994	DQA1*0104 has a guanine in the second position of the second expressed codon, whereas DQA1*0101 and all other sequenced DQA1 alleles have an adenine in that position, changing aspartic acid to glycine.	Aspartic Acid	176-189	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	86-90
7516581-5	1994	The location of Mn2+ and deoxyadenosine triphosphate in pol beta confirms the role of the invariant aspartates in metal ion and deoxynucleoside triphosphate binding.	Aspartic Acid	100-110	DNA polymerase beta	Rattus norvegicus	56-64
8002982-0	1994	Mutation of aspartate residues in the third extracellular loop of the rat B2 bradykinin receptor decreases affinity for bradykinin.	Aspartic Acid	12-21	bradykinin receptor B2	Rattus norvegicus	74-96
8003467-6	1994	We propose instead that the N5 protonated form of H2folate is stabilized directly at the active site in the DHFR/NADPH/H2folate complex by specific interactions that form only in the ternary complex, involving perhaps a bound water molecule, the carboxamide moiety of the coenzyme, and/or the local electrostatic field of the enzyme molecule, to which an important contribution may be made by Asp-27.	Aspartic Acid	393-396	Dihydrofolate reductase	Escherichia coli	108-112
8010953-1	1994	Osteopontin is a phosphorylated sialoprotein containing a conserved sequence of contiguous aspartic acid residues.	Aspartic Acid	91-104	secreted phosphoprotein 1	Homo sapiens	0-11
8010953-6	1994	The synthetic polypeptide poly(aspartic acid) was almost as effective an inhibitor of HA formation as osteopontin (IC50 0.11 microgram/ml), whereas poly(glutamic acid) was more than a thousand times less potent (IC50 155 micrograms/ml).	Aspartic Acid	31-44	secreted phosphoprotein 1	Homo sapiens	102-113
8010958-0	1994	The effect of replacing the conserved active-site residues His-264, Asp-312 and Arg-314 on the binding and catalytic properties of Escherichia coli citrate synthase.	Aspartic Acid	68-71	citrate synthase	Sus scrofa	148-164
8010958-2	1994	Active-site residues Arg-314, Asp-312 and His-264 in Escherichia coli citrate synthase, which are involved in oxaloacetate binding, were converted by site-directed mutagenesis to Gln-314, Asn-312 and Asn-264 respectively.	Aspartic Acid	30-33	citrate synthase	Sus scrofa	70-86
7980208-9	1994	His grandmother was heterozygous for Pi Null Bellingham and the additional rare variant P Lowell, Asp 256 (GAT) to Val (GTT), a variant that also results in alpha-1-antitrypsin deficiency.	Aspartic Acid	98-101	glycine-N-acyltransferase	Homo sapiens	107-110
7948575-1	1994	A cell adhesive peptide, Arg-Gly-Asp-Ser (RGDS), enhances leucocyte response to stimuli when insolubilized or conjugated with proteins.	Aspartic Acid	33-36	ral guanine nucleotide dissociation stimulator	Homo sapiens	42-46
8002937-2	1994	Two molecular forms of insulin which differ by a single amino acid substitution, His or Asp at position 15 of the A chain, were isolated from the pancreas of the paddlefish.	Aspartic Acid	88-91	insulin	Homo sapiens	23-30
7980208-9	1994	His grandmother was heterozygous for Pi Null Bellingham and the additional rare variant P Lowell, Asp 256 (GAT) to Val (GTT), a variant that also results in alpha-1-antitrypsin deficiency.	Aspartic Acid	98-101	serpin family A member 1	Homo sapiens	157-176
8075622-9	1994	Interpreting this localisation together with information from the literature, the following functions are suggested during resorption: Osteocalcin may act as a chemoattractant for osteoclasts, while both osteopontin and bone sialoprotein may facilitate the binding of osteoclasts via the arg-gly-asp motif.	Aspartic Acid	296-299	bone gamma-carboxyglutamate protein	Homo sapiens	135-146
8189507-8	1994	Mutagenesis of the first aspartate residue of the motif, located at position 628 of the UL52 protein, abolished the ability of the complex to support replication of an origin-containing plasmid in vivo and to synthesize oligoribonucleotide primers in vitro.	Aspartic Acid	25-34	helicase-primase primase subunit	Human alphaherpesvirus 1	88-92
8189060-9	1994	The data indicate that the negative charge of residue Asp-112 plays a major role in the formation of the C1q-binding site of CRP and that the positively-charged residue Lys-114 and to a lesser extent also Arg-116 play important but indirect roles in C1q-binding and activation of C by CRP complexes.	Aspartic Acid	54-57	complement C1q A chain	Homo sapiens	105-108
8189060-9	1994	The data indicate that the negative charge of residue Asp-112 plays a major role in the formation of the C1q-binding site of CRP and that the positively-charged residue Lys-114 and to a lesser extent also Arg-116 play important but indirect roles in C1q-binding and activation of C by CRP complexes.	Aspartic Acid	54-57	C-reactive protein	Homo sapiens	125-128
7974343-7	1994	The protein C from patients bearing the mutations Arg-5 to Trp, Arg-1 to Cys and Glu 7 to Asp bound poorly to H11 mAb, even in the absence of calcium ions.	Aspartic Acid	90-93	proline rich protein HaeIII subfamily 1	Homo sapiens	4-13
7911325-3	1994	Mutants of recombinant progelatinase A, altered such that the proposed active site glutamic acid residue (E375) was replaced by either an aspartic acid (proE375--&gt;D), an alanine (proE375--&gt;A) or a glutamine (proE375--&gt;Q), were purified from medium conditioned by transfected NS0 mouse myeloma cells.	Aspartic Acid	138-151	matrix metallopeptidase 2	Homo sapiens	23-38
7974349-7	1994	The epitope of MAb 9, which inhibits the binding of vWF to GPIIb/IIIa, was identified in the C-terminal part of the vWF subunit between Gln 1704 and Asp 1746, the latter being the third aa of the RGD sequence common to adhesive proteins and serving as a recognition site for integrin receptors.	Aspartic Acid	149-152	von Willebrand factor	Homo sapiens	52-55
7974349-7	1994	The epitope of MAb 9, which inhibits the binding of vWF to GPIIb/IIIa, was identified in the C-terminal part of the vWF subunit between Gln 1704 and Asp 1746, the latter being the third aa of the RGD sequence common to adhesive proteins and serving as a recognition site for integrin receptors.	Aspartic Acid	149-152	integrin subunit alpha 2b	Homo sapiens	59-64
7974349-7	1994	The epitope of MAb 9, which inhibits the binding of vWF to GPIIb/IIIa, was identified in the C-terminal part of the vWF subunit between Gln 1704 and Asp 1746, the latter being the third aa of the RGD sequence common to adhesive proteins and serving as a recognition site for integrin receptors.	Aspartic Acid	149-152	von Willebrand factor	Homo sapiens	116-119
8186255-1	1994	Site-directed mutagenesis was used to alter the amino-acid residues at the presumed catalytic site Cys-283 and ATP binding site Asp-340 of human creatine kinase B cDNA.	Aspartic Acid	128-131	creatine kinase B	Homo sapiens	145-162
8196050-5	1994	The catalytic water was clearly observed between the two aspartates which were not perfectly co-planar, and in this structure the active site cleft is more restricted than for either inhibitor bound or ligand-free HIV-1 proteinase.	Aspartic Acid	57-67	endogenous retrovirus group K member 25	Homo sapiens	220-230
8185629-1	1994	A cyclic hexapeptide, cyclo(-D-Asp-Trp-Asp-D-Leu-Leu-D-Trp-), designed from cyclo(-D-Glu-Ala-D-alloisoleucyl-Leu-D-Trp-), an ETA receptor-selective antagonist, possessed not only affinity similar to that of BQ-123 for ETA but also higher affinity for ETB than BQ-123.	Aspartic Acid	30-34	endothelin receptor type A	Homo sapiens	125-128
8193120-8	1994	The structure is partially stabilized by a charged hydrogen bond between the side chains of Arg-1 and Asp-3.	Aspartic Acid	102-105	arginase 1	Homo sapiens	92-97
8182055-0	1994	A glycine to aspartic acid change in the MoCo domain of nitrate reductase reduces both activity and phosphorylation levels in Arabidopsis.	Aspartic Acid	13-26	nitrate reductase 1	Arabidopsis thaliana	56-73
8182055-7	1994	Comparison of the sequences of the wild-type and chl3-1 NIA2 genes revealed a single base mutation changing a glycine codon to an aspartic acid codon.	Aspartic Acid	130-143	nitrate reductase 2	Arabidopsis thaliana	56-60
8185629-1	1994	A cyclic hexapeptide, cyclo(-D-Asp-Trp-Asp-D-Leu-Leu-D-Trp-), designed from cyclo(-D-Glu-Ala-D-alloisoleucyl-Leu-D-Trp-), an ETA receptor-selective antagonist, possessed not only affinity similar to that of BQ-123 for ETA but also higher affinity for ETB than BQ-123.	Aspartic Acid	30-34	endothelin receptor type A	Homo sapiens	218-221
8185321-9	1994	Moreover, the pyc1 null showed a strong requirement for L-aspartate for efficient growth, indicating the importance of PYC1 expression for the synthesis of C4 intermediates.	Aspartic Acid	56-67	pyruvate carboxylase 1	Saccharomyces cerevisiae S288C	14-18
8185629-1	1994	A cyclic hexapeptide, cyclo(-D-Asp-Trp-Asp-D-Leu-Leu-D-Trp-), designed from cyclo(-D-Glu-Ala-D-alloisoleucyl-Leu-D-Trp-), an ETA receptor-selective antagonist, possessed not only affinity similar to that of BQ-123 for ETA but also higher affinity for ETB than BQ-123.	Aspartic Acid	30-34	endothelin receptor type B	Homo sapiens	251-254
8185629-2	1994	Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively.	Aspartic Acid	54-57	N-acylsphingosine amidohydrolase 1	Homo sapiens	62-65
8185629-2	1994	Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively.	Aspartic Acid	54-57	N-acylsphingosine amidohydrolase 1	Homo sapiens	94-97
8185629-2	1994	Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively.	Aspartic Acid	54-57	endothelin receptor type A	Homo sapiens	204-207
8185629-2	1994	Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively.	Aspartic Acid	54-57	endothelin receptor type B	Homo sapiens	212-215
8185321-10	1994	DV6.2 (PYC1, pyc2 delta) showed a 3.2-fold higher level of activity on ethanol minimal medium when compared to growth on glucose minimal medium, and supported growth in the absence of L-aspartate.	Aspartic Acid	184-195	pyruvate carboxylase 1	Saccharomyces cerevisiae S288C	7-11
8198521-1	1994	Asp-130 of the recombinant skeletal-muscle 6-phosphofructo-2-kinase (PFK-2)/fructose-2,6-bisphosphatase was mutated into Ala in order to study its role in catalysis and/or substrate binding.	Aspartic Acid	0-3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	69-74
8185321-10	1994	DV6.2 (PYC1, pyc2 delta) showed a 3.2-fold higher level of activity on ethanol minimal medium when compared to growth on glucose minimal medium, and supported growth in the absence of L-aspartate.	Aspartic Acid	184-195	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	13-17
8175783-5	1994	In the second group (Group 2), replacement with Gly, Pro, Ser, or Asp resulted in nonfunctional EF-2, but it did not affect the growth of cells co-expressing wild-type EF-2.	Aspartic Acid	66-69	elongation factor 2	Saccharomyces cerevisiae S288C	96-100
8163950-4	1994	However, each of these mAbs failed to select further antigenic variants of IMUT4, in ovo, but rather a receptor binding mutant (HA1 190 Glu--&gt;Asp; 226 Leu--&gt;Gln) that was still recognized by the selecting mAb, specific for HA1 155 of X31 virus.	Aspartic Acid	145-148	Rho GTPase activating protein 45	Mus musculus	128-131
7513208-4	1994	Sequencing of the whole coding region of c-kit cDNA showed that c-kit cDNA of P-815 cells carries a point mutation in codon 814, resulting in amino acid substitution of Tyr for Asp.	Aspartic Acid	177-180	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	41-46
7513208-4	1994	Sequencing of the whole coding region of c-kit cDNA showed that c-kit cDNA of P-815 cells carries a point mutation in codon 814, resulting in amino acid substitution of Tyr for Asp.	Aspartic Acid	177-180	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	64-69
7947250-3	1994	The cloning and sequencing of the G6PD Modena allele showed a G--&gt;C transition at nucleotide 844 in exon VIII causing a Asp--&gt;His amino acid substitution.	Aspartic Acid	123-126	glucose-6-phosphate dehydrogenase	Homo sapiens	34-38
7947250-3	1994	The cloning and sequencing of the G6PD Modena allele showed a G--&gt;C transition at nucleotide 844 in exon VIII causing a Asp--&gt;His amino acid substitution.	Aspartic Acid	123-126	cytochrome c oxidase subunit 8A	Homo sapiens	108-112
7523264-5	1994	In contrast, p43-58 related peptides carrying aspartic acid(D) at position 46 and A at position 54 bound most potently to I-Ak molecules, and the peptides with arginine(R) at position 46 and A at position 54 bound most efficiently to I-Av molecules.	Aspartic Acid	46-59	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	Mus musculus	13-16
7513946-6	1994	Patient 3 was heterozygous for an A-to-C substitution at codon 543, changing an encoded aspartate (GAC) to alanine (GCC); the PFK-M gene on the other allele was not expressed, but sequencing of the reported regulatory region of the gene did not reveal any mutation.	Aspartic Acid	88-97	guanylate cyclase 2C	Homo sapiens	116-119
8012773-6	1994	The remaining mutations was a G to A transition altering GGC to GAC, producing a glycine to aspartic acid substitution, which has not previously been reported in bladder cancer.	Aspartic Acid	92-105	gamma-glutamylcyclotransferase	Homo sapiens	57-60
7928380-0	1994	Hb Seattle [beta 70(E14)Ala- > Asp]: a report of a second kindred in a Ukrainian family.	Aspartic Acid	31-34	nuclear protein, coactivator of histone transcription	Homo sapiens	0-23
7513610-6	1994	In cell adhesion assays, the 69-6-5 mAb was able to inhibit strongly in a dose-dependent manner arginine-glycine-aspartic acid-mediated adhesion of HT29-D4 cells to vitronectin, fibronectin, or ProNectin F but not to laminin or collagen.	Aspartic Acid	113-126	vitronectin	Homo sapiens	165-176
7527219-0	1994	Immunoreactivity between a monoclonal lupus autoantibody and the arginine/aspartic acid repeats within the U1-snRNP 70K autoantigen is conformationally restricted.	Aspartic Acid	74-87	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Mus musculus	110-115
7527219-1	1994	Immunoreactivity of the arginine/aspartic acid (RD) repeats of the 70K protein of U1 small nuclear ribonucleoprotein (snRNP) was determined to be conformationally dependent.	Aspartic Acid	33-46	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Mus musculus	118-123
7909847-2	1994	APA liberates angotensin III from angiotensin II by releasing the N-terminal aspartate, and APN participates in the inactivation of angiotensin III.	Aspartic Acid	77-86	glutamyl aminopeptidase	Homo sapiens	0-3
7909847-2	1994	APA liberates angotensin III from angiotensin II by releasing the N-terminal aspartate, and APN participates in the inactivation of angiotensin III.	Aspartic Acid	77-86	angiotensinogen	Homo sapiens	34-48
8161501-7	1994	The NMR spectrum and resulting solution structure of PAPA suggest that a side-chain to side-chain hydrogen bond involving an arginine and an aspartic acid analogous to one observed in the Zif268 protein-DNA cocrystal structure exists in solution in the absence of DNA [Pavletich, N. P., &amp; Pabo, C. O.	Aspartic Acid	141-154	pappalysin 1	Homo sapiens	53-57
8161501-7	1994	The NMR spectrum and resulting solution structure of PAPA suggest that a side-chain to side-chain hydrogen bond involving an arginine and an aspartic acid analogous to one observed in the Zif268 protein-DNA cocrystal structure exists in solution in the absence of DNA [Pavletich, N. P., &amp; Pabo, C. O.	Aspartic Acid	141-154	early growth response 1	Homo sapiens	188-194
7935140-4	1994	In the second study we also observed a single amino acid difference at position 57, with Aspartic Acid in DQB1*0503 allele and Valine in DQB1 allele, and we concluded that the presence of a DQB1 allele with the charged residue Aspartic Acid at position 57 has a role in creating susceptibility for isocyanate-induced asthma.	Aspartic Acid	89-102	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	106-110
7935140-4	1994	In the second study we also observed a single amino acid difference at position 57, with Aspartic Acid in DQB1*0503 allele and Valine in DQB1 allele, and we concluded that the presence of a DQB1 allele with the charged residue Aspartic Acid at position 57 has a role in creating susceptibility for isocyanate-induced asthma.	Aspartic Acid	89-102	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	137-141
7935140-4	1994	In the second study we also observed a single amino acid difference at position 57, with Aspartic Acid in DQB1*0503 allele and Valine in DQB1 allele, and we concluded that the presence of a DQB1 allele with the charged residue Aspartic Acid at position 57 has a role in creating susceptibility for isocyanate-induced asthma.	Aspartic Acid	89-102	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	137-141
7935140-4	1994	In the second study we also observed a single amino acid difference at position 57, with Aspartic Acid in DQB1*0503 allele and Valine in DQB1 allele, and we concluded that the presence of a DQB1 allele with the charged residue Aspartic Acid at position 57 has a role in creating susceptibility for isocyanate-induced asthma.	Aspartic Acid	227-240	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	106-110
7935140-4	1994	In the second study we also observed a single amino acid difference at position 57, with Aspartic Acid in DQB1*0503 allele and Valine in DQB1 allele, and we concluded that the presence of a DQB1 allele with the charged residue Aspartic Acid at position 57 has a role in creating susceptibility for isocyanate-induced asthma.	Aspartic Acid	227-240	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	137-141
7935140-4	1994	In the second study we also observed a single amino acid difference at position 57, with Aspartic Acid in DQB1*0503 allele and Valine in DQB1 allele, and we concluded that the presence of a DQB1 allele with the charged residue Aspartic Acid at position 57 has a role in creating susceptibility for isocyanate-induced asthma.	Aspartic Acid	227-240	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	137-141
7915014-6	1994	Decreases in Asp and Tau in OB and Ser in A, an increase in Gln in IC were only observed after repeated seizures, in Rb1 and Rb2 mice.	Aspartic Acid	13-16	RB transcriptional corepressor 1	Mus musculus	117-120
7915014-6	1994	Decreases in Asp and Tau in OB and Ser in A, an increase in Gln in IC were only observed after repeated seizures, in Rb1 and Rb2 mice.	Aspartic Acid	13-16	RB transcriptional corepressor like 2	Mus musculus	125-128
8163200-3	1994	Comparison of the nucleotide (nt) sequences showed a single transition: G--&gt;A in the second base of codon 690 of the tsBN462 CCG1 cDNA, resulting in a Gly690--&gt;Asp change.	Aspartic Acid	166-169	transcription initiation factor TFIID subunit 1	Mesocricetus auratus	128-132
8157637-5	1994	Site-directed mutagenesis was employed to generate three mutant LIM2 proteins with conversions of the second conserved cysteine to histidine (C2H), the fifth conserved cysteine to histidine (C5H), and the last conserved cysteine to aspartate (C8D).	Aspartic Acid	232-241	lens intrinsic membrane protein 2	Homo sapiens	64-68
7513610-6	1994	In cell adhesion assays, the 69-6-5 mAb was able to inhibit strongly in a dose-dependent manner arginine-glycine-aspartic acid-mediated adhesion of HT29-D4 cells to vitronectin, fibronectin, or ProNectin F but not to laminin or collagen.	Aspartic Acid	113-126	fibronectin 1	Homo sapiens	178-189
8155728-4	1994	The fact that butyrate ester has the optimum acyl-chain length to be a substrate of LPL can be attributed to its chain length being long enough for optimum interaction with the active site His-Ser-Asp triad in forming the transition state complex; yet it is short enough to provide freedom for optimum positioning of the ester bond for transition state complex formation.	Aspartic Acid	197-200	lipoprotein lipase	Homo sapiens	84-87
8087556-11	1994	CONCLUSION: The structure of Candida antarctica lipase B shows that the enzyme has a Ser-His-Asp catalytic triad in its active site.	Aspartic Acid	93-96	PAN0_003d1715	Moesziomyces antarcticus	48-54
8155647-9	1994	Site-directed modification of VDR serine 205 to alanine, aspartate, or glutamate each led to fully functional proteins when assessed in a transactivation assay using several VDRE-linked natural promoters.	Aspartic Acid	57-66	vitamin D receptor	Homo sapiens	30-33
8144598-10	1994	These results reveal that the aggregation properties of beta 1-35 peptides are affected by racemization of their Asp residues depending on their position.	Aspartic Acid	113-116	RNA polymerase I subunit B	Homo sapiens	56-65
7511609-2	1994	Fibronectin (Fn) binding to the integrins alpha IIb beta 3 and alpha v beta 3 involves the Arg-Gly-Asp sequence.	Aspartic Acid	99-102	fibronectin 1	Homo sapiens	0-11
7913432-2	1994	The P1 and P2 synaptosomal fractions showed high affinity systems for glutamate (3 and 9 microM) and aspartate (6 and 3 microM) respectively.	Aspartic Acid	101-110	perforin 1	Rattus norvegicus	4-13
8168535-3	1994	Sequence comparison reveals that both enzymes have a conserved Asp residue (Asp650 in NEP and Asp170 in thermolysin) located four positions on the C-side of the third zinc ligand.	Aspartic Acid	63-66	membrane metalloendopeptidase	Homo sapiens	86-89
7512180-3	1994	Sequencing of c-kit cDNA revealed that c-kit genes of HMC-1 cells were composed of a normal, wild-type allele and a mutant allele with two point mutations in codon 560 and codon 816, resulting in intracellular amino acid substitutions of Gly-560 for Val and Val-816 for Asp, respectively.	Aspartic Acid	270-273	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	39-44
8183282-2	1994	IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid residue in position 57 of DQ beta chain and DQA1 alleles with an arginine residue in position 52 of DQ alpha chain.	Aspartic Acid	65-78	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	37-41
8176895-10	1994	CONCLUSIONS: We have defined the amyloidogenic region of gelsolin to a 9-residue sequence in the highly conserved repetitive motif B and showed that residue 187 represents a critical site where a substitution of an amino acid with a charged side chain (Asp) with an amino acid with an uncharged (Asn) or hydrophobic side chain (Tyr, Val) creates a conformation that is highly amyloidogenic thus providing an explanation for the amyloidogenicity of the Asn-187 and Tyr-187 gelsolin variants.	Aspartic Acid	253-256	gelsolin	Homo sapiens	57-65
8183282-5	1994	On the other hand the presence of two DQB1 alleles with aspartic acid in position 57 was sufficient to confer resistance to disease irrespective of the DQA1 genotype.	Aspartic Acid	56-69	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	38-42
8077255-1	1994	The adhesive interaction of cells with extracellular matrix components is essential for a variety of cellular functions, and is frequently mediated by a tetra peptide, Arg-Gly-Asp-Ser (RGDS), located within fibronectin and other proteins.	Aspartic Acid	176-179	ral guanine nucleotide dissociation stimulator	Homo sapiens	185-189
8028175-6	1994	I also describe our new protein engineering technique for creation of artificial cell adhesive proteins by grafting the Arg-Gly-Asp Ser (RGDS) cell recognition signal, which was identified first in fibronectin and later in various plasma and extracellular matrix proteins.	Aspartic Acid	128-131	ral guanine nucleotide dissociation stimulator	Homo sapiens	137-141
8132607-1	1994	Integrin alpha IIb-beta 3 binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser (RGDS).	Aspartic Acid	80-83	ral guanine nucleotide dissociation stimulator	Homo sapiens	89-93
8143731-9	1994	Remarkably, a reversed differential binding was observed after substitution at position 143 in hTNF; replacing Asp by non-conservative residues such as Tyr, Phe or Asn resulted in a much larger decrease in binding to R55 than to R75.	Aspartic Acid	111-114	tumor necrosis factor	Homo sapiens	95-99
8003945-1	1994	The investigation on the localization of L-asparaginase, the enzyme involved in the synthesis of L-aspartic acid, has been carried out using the immunohistochemical method.	Aspartic Acid	97-112	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	41-55
8117731-0	1994	Extent of proton transfer in the transition states of the reaction catalyzed by the delta 5-3-ketosteroid isomerase of Comamonas (Pseudomonas) testosteroni: site-specific replacement of the active site base, aspartate 38, by the weaker base alanine-3-sulfinate.	Aspartic Acid	208-217	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	84-115
8026985-7	1994	Comparison of the amino acid sequences of these DRB1 and DQB1 alleles indicates that Ser at position 57 of DRB1 and/or Glu at position 70 and Asp at position 71 of DQB1 plays a crucial role in determining the susceptibility to VKH disease.	Aspartic Acid	142-145	major histocompatibility complex, class II, DR beta 1	Homo sapiens	48-52
8026985-7	1994	Comparison of the amino acid sequences of these DRB1 and DQB1 alleles indicates that Ser at position 57 of DRB1 and/or Glu at position 70 and Asp at position 71 of DQB1 plays a crucial role in determining the susceptibility to VKH disease.	Aspartic Acid	142-145	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	57-61
8026985-7	1994	Comparison of the amino acid sequences of these DRB1 and DQB1 alleles indicates that Ser at position 57 of DRB1 and/or Glu at position 70 and Asp at position 71 of DQB1 plays a crucial role in determining the susceptibility to VKH disease.	Aspartic Acid	142-145	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	164-168
8026990-5	1994	A26.4 (A*2603) was different from the other A26 splits at three positions: 74 histidine, 76 valine, and 77 aspartate.	Aspartic Acid	107-116	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	0-3
8113684-7	1994	Competition experiments using single Ala-substituted peptides indicated that amino acid residues Asp in position 3 and Tyr in position 9 were essential for binding of the MAGE-1 peptide to HLA-A1.	Aspartic Acid	97-100	MAGE family member A1	Homo sapiens	171-177
8133057-9	1994	These results indicate that chemotaxis of PMNs in response to TGF-beta isoforms is mediated by the interaction of the Arg-gly-Asp-ser sequence in the CBD of Fn with an integrin on the PMN cell surface, primarily the VLA-5 integrin.	Aspartic Acid	126-129	transforming growth factor beta 1	Homo sapiens	62-70
8133057-9	1994	These results indicate that chemotaxis of PMNs in response to TGF-beta isoforms is mediated by the interaction of the Arg-gly-Asp-ser sequence in the CBD of Fn with an integrin on the PMN cell surface, primarily the VLA-5 integrin.	Aspartic Acid	126-129	integrin subunit alpha 5	Homo sapiens	216-221
8107847-6	1994	We show here that the mutation Gly 90--&gt;Asp (G90D) in the second transmembrane segment of rhodopsin, which causes congenital night blindness, also constitutively activates opsin.	Aspartic Acid	43-46	rhodopsin	Homo sapiens	93-102
8119968-5	1994	Additionally, a naturally occurring mutation (histidine B10 to aspartic acid) yields a form of human insulin which accumulates 10- to over 100-fold more mature insulin when compared to the mutants lacking this change.	Aspartic Acid	63-76	insulin	Homo sapiens	101-108
8119968-5	1994	Additionally, a naturally occurring mutation (histidine B10 to aspartic acid) yields a form of human insulin which accumulates 10- to over 100-fold more mature insulin when compared to the mutants lacking this change.	Aspartic Acid	63-76	insulin	Homo sapiens	160-167
8117099-9	1994	The N-terminal sequence Val-Asn-Phe-Thr-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, was identical to the N-terminal sequence of human, hamster and rat elongation factor 2 (EF-2).	Aspartic Acid	44-47	eukaryotic translation elongation factor 2	Rattus norvegicus	148-167
8117099-9	1994	The N-terminal sequence Val-Asn-Phe-Thr-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, was identical to the N-terminal sequence of human, hamster and rat elongation factor 2 (EF-2).	Aspartic Acid	44-47	eukaryotic translation elongation factor 2	Rattus norvegicus	169-173
7510428-7	1994	MT amino acid sequence comparisons and peptide blocking studies suggested aspartate-11 and threonine-14 are important antigenic determinants for B2.	Aspartic Acid	74-83	histamine N-methyltransferase	Homo sapiens	0-2
8119887-2	1994	Most mammalian S-adenosylmethionine (AdoMet)-dependent methyltransferases have a conserved aspartate residue in a sequence oDso (o denotes a hydrophobic amino acid and s denotes a small neutral amino acid).	Aspartic Acid	91-100	methionine adenosyltransferase 1A	Rattus norvegicus	37-43
8119887-3	1994	Rat guanidinoacetate methyltransferase has two aspartate residues (Asp-129 and Asp-134) conforming to the motif in close proximity to Tyr-136 that is photoaffinity-labeled by AdoMet (Takata, Y., and Fujioka, M. (1992) Biochemistry 31, 4369-4374).	Aspartic Acid	47-56	guanidinoacetate N-methyltransferase	Rattus norvegicus	4-38
8119887-3	1994	Rat guanidinoacetate methyltransferase has two aspartate residues (Asp-129 and Asp-134) conforming to the motif in close proximity to Tyr-136 that is photoaffinity-labeled by AdoMet (Takata, Y., and Fujioka, M. (1992) Biochemistry 31, 4369-4374).	Aspartic Acid	47-56	methionine adenosyltransferase 1A	Rattus norvegicus	175-181
8119887-3	1994	Rat guanidinoacetate methyltransferase has two aspartate residues (Asp-129 and Asp-134) conforming to the motif in close proximity to Tyr-136 that is photoaffinity-labeled by AdoMet (Takata, Y., and Fujioka, M. (1992) Biochemistry 31, 4369-4374).	Aspartic Acid	67-70	guanidinoacetate N-methyltransferase	Rattus norvegicus	4-38
8119887-3	1994	Rat guanidinoacetate methyltransferase has two aspartate residues (Asp-129 and Asp-134) conforming to the motif in close proximity to Tyr-136 that is photoaffinity-labeled by AdoMet (Takata, Y., and Fujioka, M. (1992) Biochemistry 31, 4369-4374).	Aspartic Acid	67-70	methionine adenosyltransferase 1A	Rattus norvegicus	175-181
8119887-3	1994	Rat guanidinoacetate methyltransferase has two aspartate residues (Asp-129 and Asp-134) conforming to the motif in close proximity to Tyr-136 that is photoaffinity-labeled by AdoMet (Takata, Y., and Fujioka, M. (1992) Biochemistry 31, 4369-4374).	Aspartic Acid	79-82	guanidinoacetate N-methyltransferase	Rattus norvegicus	4-38
8119887-3	1994	Rat guanidinoacetate methyltransferase has two aspartate residues (Asp-129 and Asp-134) conforming to the motif in close proximity to Tyr-136 that is photoaffinity-labeled by AdoMet (Takata, Y., and Fujioka, M. (1992) Biochemistry 31, 4369-4374).	Aspartic Acid	79-82	methionine adenosyltransferase 1A	Rattus norvegicus	175-181
8119887-12	1994	Thus, the large decreases in kcat/Km values for AdoMet indicate that Asp-134 is crucial for binding AdoMet.	Aspartic Acid	69-72	methionine adenosyltransferase 1A	Rattus norvegicus	48-54
8119887-12	1994	Thus, the large decreases in kcat/Km values for AdoMet indicate that Asp-134 is crucial for binding AdoMet.	Aspartic Acid	69-72	methionine adenosyltransferase 1A	Rattus norvegicus	100-106
8106526-6	1994	Consistent with this, an NH2-terminal deletion of the first 34 amino acids or an Asp insertion at residue 35 of DnaJ resulted in a protein that completely lacked DnaJ activity.	Aspartic Acid	81-84	DnaJ	Escherichia coli	112-116
8107847-8	1994	This demonstrates the proximity of Asp 90 and Lys 296 in the three-dimensional structure of rhodopsin and suggests that the constitutively activating mutations operate by a common molecular mechanism, disrupting a salt bridge between Lys 296 and the Schiff base counterion, Glu 113.	Aspartic Acid	35-38	rhodopsin	Homo sapiens	92-101
8106414-7	1994	From the sequence, we deduced that the DSP cDNA coded for 366 amino acids, predominantly Asp, Ser, Glu, and Gly.	Aspartic Acid	89-92	dentin sialophosphoprotein	Rattus norvegicus	39-42
8107101-11	1994	The two CK-2 phosphorylation sites are conserved in all known Vpu sequences and represent the consensus Ser52GlyAsn(Glu/Asp)Ser(Glu/Asp)Gly(Glu/Asp)59.	Aspartic Acid	120-123	Vpu	Human immunodeficiency virus 1	62-65
8107101-11	1994	The two CK-2 phosphorylation sites are conserved in all known Vpu sequences and represent the consensus Ser52GlyAsn(Glu/Asp)Ser(Glu/Asp)Gly(Glu/Asp)59.	Aspartic Acid	132-135	Vpu	Human immunodeficiency virus 1	62-65
8107101-11	1994	The two CK-2 phosphorylation sites are conserved in all known Vpu sequences and represent the consensus Ser52GlyAsn(Glu/Asp)Ser(Glu/Asp)Gly(Glu/Asp)59.	Aspartic Acid	132-135	Vpu	Human immunodeficiency virus 1	62-65
8106386-7	1994	Mutations of Asp into Asn in the NH2-terminal segment of C5aR further indicated that negative charges are required to endow the receptor with a C5a binding capacity.	Aspartic Acid	13-16	complement C5a receptor 1	Homo sapiens	57-61
8106386-7	1994	Mutations of Asp into Asn in the NH2-terminal segment of C5aR further indicated that negative charges are required to endow the receptor with a C5a binding capacity.	Aspartic Acid	13-16	complement C5a receptor 1	Homo sapiens	57-60
8313964-6	1994	Hydrophobic (Val) or negatively charged (Asp or Glu) substitutions were particularly disruptive, in that these variants exhibited less than 10% wild-type antithrombin or antitrypsin activity.	Aspartic Acid	41-44	serpin family C member 1	Homo sapiens	154-166
7905794-0	1994	Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.	Aspartic Acid	142-145	CD4 antigen	Mus musculus	14-17
8142585-0	1994	Conformational analysis of CCK-B agonists using 1H-NMR and restrained molecular dynamics: comparison of biologically active Boc-Trp-(N-Me) Nle-Asp-Phe-NH2 and inactive Boc-Trp-(N-Me)Phe-Asp-Phe-NH2.	Aspartic Acid	143-146	cholecystokinin B receptor	Homo sapiens	27-32
7905794-0	1994	Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.	Aspartic Acid	142-145	fibronectin 1	Mus musculus	43-54
7508942-7	1994	Specific amino acids, important for binding VLA-4 include aspartate 40 (D40), which corresponds to the acidic ICAM-1 residue glutamate 34 (E34) previously reported to be essential for binding of ICAM-1 to its integrin counter-receptor LFA-1.	Aspartic Acid	58-67	intercellular adhesion molecule 1	Homo sapiens	110-116
8293561-7	1994	In addition, the peptide GRGDSP blocked adhesion to osteopontin, suggesting that integrins mediate Arg-Gly-Asp-dependent adhesion.	Aspartic Acid	107-110	secreted phosphoprotein 1	Homo sapiens	52-63
7507461-3	1994	In this study we synthesized the recombinant polypeptide (HCV-NS5 antigen) with a 576 bp cDNA encoding a part of the NS5 region of the HCV genome that has the Gly-Asp-Asp motif.	Aspartic Acid	163-166	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	62-65
7507461-3	1994	In this study we synthesized the recombinant polypeptide (HCV-NS5 antigen) with a 576 bp cDNA encoding a part of the NS5 region of the HCV genome that has the Gly-Asp-Asp motif.	Aspartic Acid	163-166	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	117-120
7507461-3	1994	In this study we synthesized the recombinant polypeptide (HCV-NS5 antigen) with a 576 bp cDNA encoding a part of the NS5 region of the HCV genome that has the Gly-Asp-Asp motif.	Aspartic Acid	167-170	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	62-65
7507461-3	1994	In this study we synthesized the recombinant polypeptide (HCV-NS5 antigen) with a 576 bp cDNA encoding a part of the NS5 region of the HCV genome that has the Gly-Asp-Asp motif.	Aspartic Acid	167-170	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	117-120
7508942-7	1994	Specific amino acids, important for binding VLA-4 include aspartate 40 (D40), which corresponds to the acidic ICAM-1 residue glutamate 34 (E34) previously reported to be essential for binding of ICAM-1 to its integrin counter-receptor LFA-1.	Aspartic Acid	58-67	intercellular adhesion molecule 1	Homo sapiens	195-201
8300566-6	1994	When bovine erythrocyte Cu,Zn-SOD (0.5 mg/ml) was treated with 5 mM H2O2 in 50 mM sodium phosphate buffer (pH 7.2), histidine was significantly lost; however, except for a significant increase in aspartate and glutamate, nothing new appeared in the amino acid analysis of oxidized Cu,Zn-SOD.	Aspartic Acid	196-205	superoxide dismutase [Cu-Zn]	Bos taurus	24-33
8300631-13	1994	A Gly--&gt;Asp mutation in S. cerevisiae, C. neoformans, C. albicans, and H. sapiens Nmts produces temperature-sensitive growth arrest in isogenic S. cerevisiae strains with a nmt1 null allele.	Aspartic Acid	11-14	glycylpeptide N-tetradecanoyltransferase NMT1	Saccharomyces cerevisiae S288C	176-180
8300621-1	1994	To investigate whether negatively charged residues of the human Y1 neuropeptide Y (NPY) receptor are required for ligand binding, a series of mutants were constructed in which aspartic acid and glutamic acid residues present in putative extracellular domains of the Y1 receptor were systematically replaced by alanines.	Aspartic Acid	176-189	neuropeptide Y	Homo sapiens	83-86
8283039-2	1994	Of these, Fc gamma RIIb1* represents a receptor variant that is identical to IIb1 except for a single amino acid difference in the cytoplasmic tail (amino acid position 11) where a tyrosine (IIb1) is replaced by an aspartic acid (IIb1*).	Aspartic Acid	215-228	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	20-24
7907936-2	1994	The agonists L-glutamate (GLU), kainic acid (KAIN) and L-aspartate (ASP) significantly decreased CRH release, while N-methyl-D-aspartate (NMDA) and quisqualic acid (QUIS) did not affect this parameter.	Aspartic Acid	55-66	corticotropin releasing hormone	Homo sapiens	97-100
8292014-3	1994	Furthermore, the 13 N-terminal amino acid sequence of the 100-kDa protein, N-Val-Asn-Phe-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, exactly matches with that of elongation factor-2 from rat and hamster.	Aspartic Acid	93-96	eukaryotic translation elongation factor 2	Rattus norvegicus	159-178
7907936-2	1994	The agonists L-glutamate (GLU), kainic acid (KAIN) and L-aspartate (ASP) significantly decreased CRH release, while N-methyl-D-aspartate (NMDA) and quisqualic acid (QUIS) did not affect this parameter.	Aspartic Acid	68-71	corticotropin releasing hormone	Homo sapiens	97-100
7907936-5	1994	The broad-spectrum EAA receptor antagonist kynurenic acid (KYN) completely abolished ASP effects on CRH and AVP release in vitro.	Aspartic Acid	85-88	corticotropin releasing hormone	Homo sapiens	100-103
7504710-8	1994	Mast cell adhesion in the presence of SCF appeared to occur through an integrin receptor as adhesion was calcium dependent and could be blocked by an RGD (Ang, Gly, Asp)-containing peptide.	Aspartic Acid	165-168	kit ligand	Mus musculus	38-41
8286339-4	1994	Here the purification and characterization of a protease from Alzheimer"s disease brain capable of cleaving a 10 amino acid synthetic substrate flanking the N terminus of A beta at the Met-Asp bond are described.	Aspartic Acid	189-192	amyloid beta precursor protein	Homo sapiens	171-177
8031011-4	1994	The substitution of neutral asparagine for anionic aspartic acid is consistent with the more cathodal electrophoretic migration of ADA 2 as compared with ADA 1.	Aspartic Acid	51-64	transcriptional adaptor 2A	Homo sapiens	131-136
8031011-4	1994	The substitution of neutral asparagine for anionic aspartic acid is consistent with the more cathodal electrophoretic migration of ADA 2 as compared with ADA 1.	Aspartic Acid	51-64	transcriptional adaptor 1	Homo sapiens	154-159
8263031-10	1994	Adding the synthetic peptide, arg-gly-asp-ser (RGDS) to the medium, blocked migration on fibronectin-coated implants but had no effect on implants coated with type IV, suggesting that migration on type IV involves different cell surface receptors than those mediating migration over fibronectin.	Aspartic Acid	38-41	ral guanine nucleotide dissociation stimulator	Homo sapiens	47-51
8263031-10	1994	Adding the synthetic peptide, arg-gly-asp-ser (RGDS) to the medium, blocked migration on fibronectin-coated implants but had no effect on implants coated with type IV, suggesting that migration on type IV involves different cell surface receptors than those mediating migration over fibronectin.	Aspartic Acid	38-41	fibronectin 1	Homo sapiens	89-100
8263031-10	1994	Adding the synthetic peptide, arg-gly-asp-ser (RGDS) to the medium, blocked migration on fibronectin-coated implants but had no effect on implants coated with type IV, suggesting that migration on type IV involves different cell surface receptors than those mediating migration over fibronectin.	Aspartic Acid	38-41	fibronectin 1	Homo sapiens	283-294
8276829-2	1994	We report properties of five active site mutants of Escherichia coli citrate synthase, in which histidine 264, aspartate 362, and phenylalanine 383 were replaced by alanines, and arginines 387 and 407 by leucines.	Aspartic Acid	111-120	citrate synthase	Sus scrofa	69-85
8276829-5	1994	The mutations of histidine 264 and aspartate 362 affect steady-state kinetics as would be anticipated from current models for citrate synthase catalysis, and resemble mutations of these residues, in pig heart and E. coli enzyme, reported by others.	Aspartic Acid	35-44	citrate synthase	Sus scrofa	126-142
7903287-1	1994	CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly--&gt;Asp).	Aspartic Acid	89-92	CD4 molecule	Homo sapiens	0-3
7903287-1	1994	CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly--&gt;Asp).	Aspartic Acid	89-92	CD8a molecule	Homo sapiens	9-12
9063817-7	1994	Nucleotide sequence analysis of ALDH2 genes in both LEC and LEA rats demonstrated that the point mutation of the codon for residue 67 encoding Gln to Asp was observed; this was not so in either Long-Evans rats or Wistar rats.	Aspartic Acid	150-153	aldehyde dehydrogenase 2 family member	Rattus norvegicus	32-37
7984499-5	1994	Rabbit PYY differs from porcine PYY, which is identical to rat and canine PYY, by two amino acid substitutions at positions 3 (Ser instead of Ala) and 18 (Asp instead of Ser), whereas rabbit PYY and human PYY differ by only one residue at position 3 (Ser instead of Ile).	Aspartic Acid	155-158	peptide YY	Oryctolagus cuniculus	7-10
7903356-1	1994	In the present study, extracellular levels of the neuropeptide cholecystokinin (CCK), of the monoamine dopamine and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and of the excitatory amino acids glutamate and aspartate were simultaneously monitored by microdialysis in the neostriatum of halothane-anesthetized rats under basal and K(+)-depolarizing conditions.	Aspartic Acid	248-257	cholecystokinin	Rattus norvegicus	80-83
8152339-7	1994	Similarly, when platelet GpIIb/IIIa receptors were blocked in normal platelets by the tripeptide Arg-Gly-Asp (RGD) or the tetrapeptide Arg-Gly-Asp-Ser (RGDS) at 10(-3) M, agonist-induced platelet aggregation and fibrinogen binding were blocked, but platelet PAI-1 release was not blocked.	Aspartic Acid	105-108	integrin subunit alpha 2b	Homo sapiens	25-30
18472928-0	1994	A novel Mutein of TNFalpha Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine.	Aspartic Acid	50-53	tumor necrosis factor	Homo sapiens	18-26
18472928-6	1994	These results suggest that the Arg-Gly-Asp sequence introduced into the TNFalpha molecule abrogates the side effect of this cytokine such as tissue injury or shock, and that F4168 could be useful for systemic therapy.	Aspartic Acid	39-42	tumor necrosis factor	Homo sapiens	72-80
7712117-0	1994	Analysis of the conserved Asp(114) residue of the dopamine D2 receptor in schizophrenic patients.	Aspartic Acid	26-29	dopamine receptor D2	Homo sapiens	50-70
7838896-4	1994	The sensitivity of the technique was confirmed by observing chemical shift differences between these two experimental conditions of the amino carbons (C-2"s) of glutamate, glutamine, N-carbamoylaspartate and aspartate.	Aspartic Acid	194-203	complement C2	Rattus norvegicus	151-154
7712117-3	1994	In this study we have found the Asp(114) in the dopamine D2 receptor to be unaltered in 72 unrelated schizophrenic individuals including 12 patients classified according to their response to chlorpromazine.	Aspartic Acid	32-35	dopamine receptor D2	Homo sapiens	48-68
8197477-1	1994	Argininosuccinate synthetase (ASS) is a urea cycle enzyme that forms argininosuccinate from citrulline and aspartate.	Aspartic Acid	107-116	argininosuccinate synthetase 1	Mus musculus	0-28
8197477-1	1994	Argininosuccinate synthetase (ASS) is a urea cycle enzyme that forms argininosuccinate from citrulline and aspartate.	Aspartic Acid	107-116	argininosuccinate synthetase 1	Mus musculus	30-33
7809956-7	1994	It is possible that the smallest sodium ID50 for 1-isoproterenol-stimulated adenylate cyclase is conditioned by sodium interaction with carboxylate residue of aspartate-79 from the cytoplasmic compartment of beta 2-adrenergic receptor (Horstman et al., 1990).	Aspartic Acid	159-168	adrenoceptor beta 2	Homo sapiens	208-234
7925478-3	1993	An increased rate of actin polymerization was found in "aggregating" conditions as compared to "activating" conditions, the latter achieved by either absence of stirring or stirring in the presence of the tetrapeptide Arg-Gly-Asp-Ser (RGDS).	Aspartic Acid	226-229	ral guanine nucleotide dissociation stimulator	Homo sapiens	235-239
8112408-0	1993	The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.	Aspartic Acid	69-78	carbonic anhydrase 1	Homo sapiens	111-114
8267569-0	1993	Importance of Asp1191 for tyrosine kinase activity of the insulin receptor: functional difference of universally conserved Asp between tyrosine kinase and c-AMP dependent serine/threonine protein kinase.	Aspartic Acid	14-17	insulin receptor	Homo sapiens	58-74
8267569-0	1993	Importance of Asp1191 for tyrosine kinase activity of the insulin receptor: functional difference of universally conserved Asp between tyrosine kinase and c-AMP dependent serine/threonine protein kinase.	Aspartic Acid	14-17	cathelicidin antimicrobial peptide	Homo sapiens	155-160
8267569-1	1993	Asp1191 of the tyrosine kinase domain in the insulin receptor is located in the almost perfectly conserved Ser-Asp-X-Trp motif of all tyrosine kinases, and the function of the motif has not been clarified.	Aspartic Acid	0-3	insulin receptor	Homo sapiens	45-61
8267574-5	1993	The results indicate that the major groups in TCS bound to Ca(II) ions should be the carboxylic side groups of the glutamic acid and/or aspartic acid.	Aspartic Acid	136-149	carbonic anhydrase 2	Homo sapiens	59-65
8032070-8	1993	Only 22.9% were homozygous for DQ beta 57-Asp, compared with 96% of American diabetic subjects in a previous study.	Aspartic Acid	42-45	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	31-38
8243830-0	1993	Ala1048--&gt;Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance.	Aspartic Acid	13-16	insulin receptor	Homo sapiens	50-66
8243830-0	1993	Ala1048--&gt;Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance.	Aspartic Acid	13-16	insulin	Homo sapiens	50-57
8243830-1	1993	We identified a heterozygous missense mutation that substituted aspartic acid (GAC) for alanine (GCC) at codon 1048 of the insulin receptor gene in a patient who displayed typical symptoms of Type A syndrome of insulin resistance.	Aspartic Acid	64-77	guanylate cyclase 2C	Homo sapiens	97-100
8243830-1	1993	We identified a heterozygous missense mutation that substituted aspartic acid (GAC) for alanine (GCC) at codon 1048 of the insulin receptor gene in a patient who displayed typical symptoms of Type A syndrome of insulin resistance.	Aspartic Acid	64-77	insulin receptor	Homo sapiens	123-139
8262934-0	1993	Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity.	Aspartic Acid	49-58	farnesyl diphosphate synthase	Rattus norvegicus	86-115
8262934-6	1993	In order to determine the importance of these domains in catalysis, the conserved aspartates or arginines in domains I and II of rat farnesyl diphosphate synthase were individually mutated to glutamate or lysine, respectively.	Aspartic Acid	82-92	farnesyl diphosphate synthase	Rattus norvegicus	133-162
8112408-2	1993	This study demonstrated that 10-30 microM riluzole reduces the K(+)-evoked release of glutamate and aspartate from slices of hippocampal area CA1.	Aspartic Acid	100-109	carbonic anhydrase 1	Homo sapiens	142-145
8261418-1	1993	The Chinese hamster lung cell line DC-3F contains two polymorphic dihydrofolate reductase (DHFR) alleles that are defined by an Asp-Asn amino acid sequence difference at position 95 in protein.	Aspartic Acid	128-131	dihydrofolate reductase	Cricetulus griseus	66-89
8261418-1	1993	The Chinese hamster lung cell line DC-3F contains two polymorphic dihydrofolate reductase (DHFR) alleles that are defined by an Asp-Asn amino acid sequence difference at position 95 in protein.	Aspartic Acid	128-131	dihydrofolate reductase	Cricetulus griseus	91-95
8265636-4	1993	Superposition of the CyPC-CsA structure with the unligated cyclophilin A (CyPA) revealed significant migration of three loops: Gln-179 to Thr-189, Asp-47 to Lys-49, and Met-170 to Ile-176.	Aspartic Acid	147-150	peptidylprolyl isomerase C	Mus musculus	21-25
8265636-4	1993	Superposition of the CyPC-CsA structure with the unligated cyclophilin A (CyPA) revealed significant migration of three loops: Gln-179 to Thr-189, Asp-47 to Lys-49, and Met-170 to Ile-176.	Aspartic Acid	147-150	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	26-29
8265636-4	1993	Superposition of the CyPC-CsA structure with the unligated cyclophilin A (CyPA) revealed significant migration of three loops: Gln-179 to Thr-189, Asp-47 to Lys-49, and Met-170 to Ile-176.	Aspartic Acid	147-150	peptidylprolyl isomerase A	Mus musculus	59-72
8265636-4	1993	Superposition of the CyPC-CsA structure with the unligated cyclophilin A (CyPA) revealed significant migration of three loops: Gln-179 to Thr-189, Asp-47 to Lys-49, and Met-170 to Ile-176.	Aspartic Acid	147-150	peptidylprolyl isomerase A	Mus musculus	74-78
8254036-1	1993	Osteopontin is a phosphorylated, sialic acid-rich, noncollagenous bone matrix protein containing the Arg-Gly-Asp-Ser amino acid sequence responsible for cell adhesion.	Aspartic Acid	109-112	secreted phosphoprotein 1	Homo sapiens	0-11
8138033-13	1993	Furthermore, all the amino acid replacements correspond to single point DNA mutations and (with the exception of the substitution Asp 22--&gt;Asn in the beta 2-globin) involve uncharged substitutions.	Aspartic Acid	130-133	beta globin minor gene	Rattus norvegicus	153-166
8245129-8	1993	The targeting of LTGF-beta to smooth muscle cells is mediated by LAP, and the domain of LAP responsible for the targeting to smooth muscle cells may not be related to mannose-6-phosphate or an Arg-Gly-Asp sequence, both of which have been previously proposed as candidates for the cellular binding domains within LAP.	Aspartic Acid	201-204	transforming growth factor beta 1	Homo sapiens	88-91
8245129-8	1993	The targeting of LTGF-beta to smooth muscle cells is mediated by LAP, and the domain of LAP responsible for the targeting to smooth muscle cells may not be related to mannose-6-phosphate or an Arg-Gly-Asp sequence, both of which have been previously proposed as candidates for the cellular binding domains within LAP.	Aspartic Acid	201-204	transforming growth factor beta 1	Homo sapiens	88-91
8245770-5	1993	Three-dimensional computer models of H-2Dds/peptide complexes, based on the crystallographic structure of the human HLA-B27/peptide complex, showed that the basic residue at position 5 was in position to form a salt bridge with aspartic acid at position 156, a polymorphic residue of the H-2Dd heavy (H) chain.	Aspartic Acid	228-241	major histocompatibility complex, class I, B	Homo sapiens	116-123
8304052-1	1993	The bone sialoprotein osteopontin (OPN) promotes cell attachment and spreading through its RGD (Arg-Gly-Asp) sequence.	Aspartic Acid	104-107	secreted phosphoprotein 1	Rattus norvegicus	22-33
8304052-1	1993	The bone sialoprotein osteopontin (OPN) promotes cell attachment and spreading through its RGD (Arg-Gly-Asp) sequence.	Aspartic Acid	104-107	secreted phosphoprotein 1	Rattus norvegicus	35-38
8282833-2	1993	These include DR3 and DR4 alleles at the DRB1 locus, presence or absence of aspartic acid at position 57 (Asp-57) of the DQB1 locus, and presence or absence of arginine at position 52 (Arg-52) of the DQA1 locus.	Aspartic Acid	106-109	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	121-125
8133203-1	1993	The gonadotrophin-releasing hormone (GnRH) receptor is unlike other G-protein coupled receptors in that the highly conserved amino acids, Asp in the second transmembrane region and Asn in the seventh, are interchanged.	Aspartic Acid	138-141	gonadotropin releasing hormone receptor	Rattus norvegicus	4-51
8136024-3	1993	The further substitution of Asp for B10 His in [B16 Phe, B26 Phe]insulin raises its activity to approximately twofold greater than natural insulin, an increase of approximately fivefold over the parent compound.	Aspartic Acid	28-31	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	36-39
8136024-3	1993	The further substitution of Asp for B10 His in [B16 Phe, B26 Phe]insulin raises its activity to approximately twofold greater than natural insulin, an increase of approximately fivefold over the parent compound.	Aspartic Acid	28-31	insulin	Homo sapiens	65-72
8136024-3	1993	The further substitution of Asp for B10 His in [B16 Phe, B26 Phe]insulin raises its activity to approximately twofold greater than natural insulin, an increase of approximately fivefold over the parent compound.	Aspartic Acid	28-31	insulin	Homo sapiens	139-146
8248221-4	1993	arcA, thus, is a plant hormone-regulated gene that encodes a protein structurally related to the beta subunit of a guanine nucleotide-binding regulatory protein, which is composed of seven repetitive segments of Trp-Asp 40-aa repeats.	Aspartic Acid	216-219	guanine nucleotide-binding protein subunit beta-like protein	Nicotiana tabacum	0-4
8226983-5	1993	Only substitution of gamma-carboxyglutamic acid 6 with aspartic acid yields a protein with procoagulant activity, affinity for phospholipid and KM(app) for prothrombinase indistinguishable from wild-type prothrombin.	Aspartic Acid	55-68	coagulation factor X	Homo sapiens	156-170
7902300-3	1993	4 nmol of tempamine per mg SR protein can be coupled to either a glu or an asp side chain through the EDC reaction.	Aspartic Acid	75-78	RNA binding protein with serine rich domain 1	Homo sapiens	27-37
8226939-0	1993	Phosphorylation/dephosphorylation of the receiver module at the conserved aspartate residue controls transphosphorylation activity of histidine kinase in sensor protein ArcB of Escherichia coli.	Aspartic Acid	74-83	hypothetical protein	Escherichia coli	169-173
7504269-0	1993	Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.	Aspartic Acid	136-139	insulin-like growth factor-binding protein 1	Cricetulus griseus	0-44
8250906-2	1993	The helix-stabilizing tendency of N-terminal amino acid in NPY (12-36) was found to be as follows: Thr &gt; Ser &gt; Gly &gt; Gln &gt; Cys &gt; Asn &gt; Asp &gt; Val &gt; Phe &gt; Glu &gt; Lys &gt; Tyr &gt; Ala = Trp &gt; His &gt; Arg, suggesting the importance of end capping.	Aspartic Acid	153-156	neuropeptide Y	Homo sapiens	59-62
7904887-6	1993	The differential staining pattern for GLU, SP, and CGRP, the differential release of ASP and GLU, and the differential activation of the EAA and NK1 receptors implies that ASP, GLU, SP, and CGRP are each involved in the processing of sensory information and that their roles in the central sensitization occurring with the inflammatory process, are unique.	Aspartic Acid	172-175	tachykinin precursor 1	Homo sapiens	145-148
8227358-5	1993	A repeating octapeptide of Arg-Ser-Arg-Ser-Arg(Lys)-Glu(Asp)-Arg-Lys(Arg) was present in RS region of HCC1.	Aspartic Acid	56-59	C-C motif chemokine ligand 14	Homo sapiens	102-106
8226858-0	1993	The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions.	Aspartic Acid	14-23	epidermal growth factor	Homo sapiens	60-83
8270132-5	1993	One allele contains in-frame 12 additional base pairs in exon 3 coding for the amino acids Leu-His-Leu-Val located between Asp-261 and Leu-262 in the receptor"s extracellular domain, being the first report of an insertion mutation of the insulin receptor gene.	Aspartic Acid	123-126	insulin receptor	Homo sapiens	238-254
8113224-6	1993	We also show that a synthetic peptide representing the domain of OP which contains nine consecutive aspartic acid residues binds Ca2+ with specificity.	Aspartic Acid	100-113	secreted phosphoprotein 1	Rattus norvegicus	65-67
8226858-0	1993	The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions.	Aspartic Acid	147-160	epidermal growth factor	Homo sapiens	60-83
8226858-0	1993	The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions.	Aspartic Acid	147-160	epidermal growth factor	Homo sapiens	207-230
8226858-0	1993	The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions.	Aspartic Acid	147-160	epidermal growth factor	Homo sapiens	232-235
8282089-5	1993	We have investigated by in vitro mutagenesis whether the N-terminal extracellular sequence of the C5a receptor, which is rich in aspartic acid residues, could play some role in C5a binding.	Aspartic Acid	129-142	complement C5a receptor 1	Homo sapiens	98-110
8282089-5	1993	We have investigated by in vitro mutagenesis whether the N-terminal extracellular sequence of the C5a receptor, which is rich in aspartic acid residues, could play some role in C5a binding.	Aspartic Acid	129-142	complement C5a receptor 1	Homo sapiens	98-101
8246132-4	1993	In the presence of the aminopeptidase inhibitor amastatin, however, pA2 values of linear antagonists bearing an N-terminal Asp residue MEN 10,207 and MEN 10,376 were significantly enhanced and these pA2 values were used for analysis; a significant correlation was found between pA2 values measured in the human urinary bladder and rabbit pulmonary artery.	Aspartic Acid	123-126	carboxypeptidase Q	Homo sapiens	23-37
8246132-5	1993	The pseudopeptide analog of NKA (4-10), MDL 28,564 which also bears a N-terminal Asp residue behaved as an agonist and its action was enhanced by amastatin.	Aspartic Acid	81-84	tachykinin precursor 1	Homo sapiens	28-31
8246132-6	1993	We conclude that the NK2 receptor-mediating contraction of the human urinary bladder smooth muscle is similar to that previously characterized in the rabbit pulmonary artery (NK2A receptor category); in the human bladder smooth muscle an amastatin-sensitive peptidase (possibly aminopeptidase A) limits biological activity of linear peptide derivatives of NKA bearing a N-terminal Asp residue.	Aspartic Acid	381-384	tachykinin receptor 2	Homo sapiens	21-33
7509429-5	1993	The active amino acid sequence in fibronectin is an arginine-glycine-aspartic acid tripeptide (Arg-Gly-Asp) and it was shown that the synthetic Arg-Gly-Asp peptide specifically inhibited the adhesive function of fibronectin in trabecular meshwork samples when incubated for 30 min at a concentration of 1-2 mg/ml.	Aspartic Acid	103-106	fibronectin 1	Homo sapiens	34-45
7509429-5	1993	The active amino acid sequence in fibronectin is an arginine-glycine-aspartic acid tripeptide (Arg-Gly-Asp) and it was shown that the synthetic Arg-Gly-Asp peptide specifically inhibited the adhesive function of fibronectin in trabecular meshwork samples when incubated for 30 min at a concentration of 1-2 mg/ml.	Aspartic Acid	103-106	fibronectin 1	Homo sapiens	212-223
8218206-5	1993	Tyr-150, Arg-151, and Asp-211 of the mECI are the only amino acids with protic side chains conserved within the enzymes with isomerase activity (pTFE and FadB).	Aspartic Acid	22-25	enoyl-Coenzyme A delta isomerase 1	Mus musculus	37-41
7901852-9	1993	These results show that Asp-83 and Glu-122 are protonated both in rhodopsin and in metarhodopsin II, in agreement with the isotope effects observed in spectra measured in 2H2O.	Aspartic Acid	24-27	rhodopsin	Bos taurus	66-75
7691416-4	1993	Aspartate substitution eliminates filament assembly in vitro and renders the myosin unable to drive any tested contractile event in vivo.	Aspartic Acid	0-9	myosin heavy chain 14	Homo sapiens	77-83
8402654-5	1993	This mutation resulted in a glycine to aspartic acid substitution within the putative trans-activation domain of WT1, converting the encoded protein from a transcriptional repressor to an activator of its target DNA sequence.	Aspartic Acid	39-52	WT1 transcription factor	Homo sapiens	113-116
7691185-0	1993	Modulation of the activity of angiogenin by mutagenesis at Asp-116.	Aspartic Acid	59-62	angiogenin	Homo sapiens	30-40
8407999-5	1993	Using oligonucleotide-directed mutagenesis of the mouse glucocorticoid receptor cDNA, we have substituted alanine or aspartate for the residues phosphorylated in this ligand-dependent transcription factor.	Aspartic Acid	117-126	nuclear receptor subfamily 3, group C, member 1	Mus musculus	56-79
7691185-13	1993	The results demonstrate that the principal effect of replacing Asp-116 in angiogenin is to modulate enzymatic activity, possibly through an effect on His-114, and suggest that Asp-116 plays a role in controlling specificity.	Aspartic Acid	63-66	angiogenin	Homo sapiens	74-84
7691185-13	1993	The results demonstrate that the principal effect of replacing Asp-116 in angiogenin is to modulate enzymatic activity, possibly through an effect on His-114, and suggest that Asp-116 plays a role in controlling specificity.	Aspartic Acid	176-179	angiogenin	Homo sapiens	74-84
7764275-1	1993	The blocked-N-terminal structure of hog kidney aldose 1-epimerase (mutarotase, EC 5.1.3.3) was determined to be Ac-Val-Ser-Val-Thr-Arg-Ser-Val-Phe-Gly-Asp... by a coupling of conventional methods (enzymatic digestion, amino acid analysis, and Edman sequencing) and tandem mass spectrometry.	Aspartic Acid	151-154	galactose mutarotase	Homo sapiens	47-65
8399169-0	1993	Fourier transform infrared difference spectroscopy of rhodopsin mutants: light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation.	Aspartic Acid	145-158	rhodopsin	Homo sapiens	54-63
8399169-0	1993	Fourier transform infrared difference spectroscopy of rhodopsin mutants: light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation.	Aspartic Acid	145-158	rhodopsin	Homo sapiens	93-102
8399169-2	1993	The rhodopsin--&gt;bathorhodopsin FTIR difference spectra of the mutants Asp-83--&gt;Asn (D83N) and Glu-134--&gt;Asp (E134D) incorporated into membranes are similar to that of native rhodopsin in the photoreceptor membrane, demonstrating that the retinal chromophores of these mutants undergo a normal 11-cis to all-trans photoisomerization.	Aspartic Acid	73-76	rhodopsin	Homo sapiens	4-13
8399169-2	1993	The rhodopsin--&gt;bathorhodopsin FTIR difference spectra of the mutants Asp-83--&gt;Asn (D83N) and Glu-134--&gt;Asp (E134D) incorporated into membranes are similar to that of native rhodopsin in the photoreceptor membrane, demonstrating that the retinal chromophores of these mutants undergo a normal 11-cis to all-trans photoisomerization.	Aspartic Acid	73-76	rhodopsin	Homo sapiens	24-33
8399169-2	1993	The rhodopsin--&gt;bathorhodopsin FTIR difference spectra of the mutants Asp-83--&gt;Asn (D83N) and Glu-134--&gt;Asp (E134D) incorporated into membranes are similar to that of native rhodopsin in the photoreceptor membrane, demonstrating that the retinal chromophores of these mutants undergo a normal 11-cis to all-trans photoisomerization.	Aspartic Acid	113-116	rhodopsin	Homo sapiens	4-13
8399169-2	1993	The rhodopsin--&gt;bathorhodopsin FTIR difference spectra of the mutants Asp-83--&gt;Asn (D83N) and Glu-134--&gt;Asp (E134D) incorporated into membranes are similar to that of native rhodopsin in the photoreceptor membrane, demonstrating that the retinal chromophores of these mutants undergo a normal 11-cis to all-trans photoisomerization.	Aspartic Acid	113-116	rhodopsin	Homo sapiens	24-33
8399169-3	1993	Two bands assigned to the C = O stretching mode of Asp and/or Glu carboxylic acid groups are absent in the D83N rhodopsin--&gt;metarhodopsin II FTIR difference spectrum.	Aspartic Acid	51-54	rhodopsin	Homo sapiens	112-121
8399169-5	1993	The most straightforward explanation is that the carboxylic acid group of Asp-83 remains protonated in rhodopsin and its bleaching intermediates but undergoes an increase in its hydrogen bonding during the metarhodopsin I--&gt;metarhodopsin II transition.	Aspartic Acid	74-77	rhodopsin	Homo sapiens	103-112
8373786-2	1993	Intact fibronectin molecule and its 120 kDa fragment, containing the Arg-Gly-Asp (RGD) sequence motif, as well as a synthetic RGD-containing peptide Peptite 2000 all bound progenitor cells.	Aspartic Acid	77-80	fibronectin 1	Homo sapiens	7-18
8287052-0	1993	Synthetic Arg-Gly-Asp-Ser analogues of the cell recognition site of fibronectin that retain antimetastatic and anti-cell adhesive properties.	Aspartic Acid	18-21	fibronectin 1	Mus musculus	68-79
8376981-2	1993	An antiserum was raised against the synthetic peptide Asp-Ala-Gly-His-Gly-Gln-Ile-Ser-His [neuropeptide gamma-(1-9)-peptide, equivalent to gamma-preprotachykinin-(72-80)-peptide], that showed &lt; 1% reactivity with intact neuropeptide gamma and other tachykinins.	Aspartic Acid	54-57	crystallin, gamma E	Rattus norvegicus	104-114
8251751-4	1993	We recovered approximately 35% of the trypsin-like (tryptase) activities mediated by granzymes A and 3, respectively, and approximately 25% of the asp-ase activity of granzyme B.	Aspartic Acid	147-150	granzyme B	Homo sapiens	167-177
8251940-0	1993	In vitro aging of calmodulin generates isoaspartate at multiple Asn-Gly and Asp-Gly sites in calcium-binding domains II, III, and IV.	Aspartic Acid	76-79	calmodulin	Bos taurus	18-28
7690504-5	1993	Crystallographic data shows that a salt bridge exists between Asp 488 and Lys 465 of RNase H which stabilizes the uncleavable form of RT p66, and that substitution of Asp for Ala would prevent the formation of this salt bridge.	Aspartic Acid	62-65	DNA polymerase delta 3, accessory subunit	Homo sapiens	137-140
7690504-5	1993	Crystallographic data shows that a salt bridge exists between Asp 488 and Lys 465 of RNase H which stabilizes the uncleavable form of RT p66, and that substitution of Asp for Ala would prevent the formation of this salt bridge.	Aspartic Acid	167-170	DNA polymerase delta 3, accessory subunit	Homo sapiens	137-140
7690504-6	1993	Our results indicate that disruption of this salt bridge through mutation of Asp 488 interferes with the conformational changes that regulate the limited processing of p66 to 51 by the virus proteinase.	Aspartic Acid	77-80	DNA polymerase delta 3, accessory subunit	Homo sapiens	168-171
8268130-7	1993	The second anchor is an aspartate at relative position 4, which is likely to be the DR3(17)-specific contact site in the groove.	Aspartic Acid	24-33	TNF receptor superfamily member 25	Homo sapiens	84-87
7691885-5	1993	Sequencing of whole coding region of c-kit cDNA revealed that c-kit genes of HMC-1 cells were composed of a normal, wild-type allele and a mutant allele with two point mutations resulting in intracellular amino acid substitutions of Gly-560 for Val and Val-816 for Asp.	Aspartic Acid	265-268	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	62-67
8376405-0	1993	Type IIB mutation His-505--&gt;Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib.	Aspartic Acid	31-34	von Willebrand factor	Homo sapiens	78-99
8376405-7	1993	Relative to wild type vWF, the mutant vWF exhibited markedly increased binding to platelets at low concentrations of ristocetin, confirming the association between the His-505--&gt;Asp substitution and the type IIB vWD phenotype.	Aspartic Acid	181-184	von Willebrand factor	Homo sapiens	38-41
8376405-8	1993	The His-505--&gt;Asp mutation lies outside the disulfide loop affected by other type IIB vWD mutations and implicates a new segment of vWF in the regulation of platelet glycoprotein Ib binding.	Aspartic Acid	17-20	von Willebrand factor	Homo sapiens	135-138
8373786-4	1993	The binding of intact fibronectin and its 120 kDa fragment was inhibited in a dose-dependent fashion with increasing concentration of RGD-containing Gly-Arg-Gly-Asp-Ser peptide, but not with Gly-Arg-Gly-Glu-Ser control peptide that does not contain the RGD sequence motif.	Aspartic Acid	161-164	fibronectin 1	Homo sapiens	22-33
8025347-10	1993	The "ligand-binding pocket" of GP IIb-IIIa contains at least three sequences essential for ligand binding; fibrinogen also binds to the activated complex through identified domains, one of which, the Arg-Gly-Asp (RGD) sequence, is also found in vWF and the other adhesive proteins able to support platelet aggregation.	Aspartic Acid	208-211	integrin subunit alpha 2b	Homo sapiens	31-37
8103679-8	1993	While introducing tyrosine, tryptophan, or aspartic acid caused an almost complete loss of colchicine and adriamycin resistance in both mdr1 and mdr3, the replacement to tyrosine or tryptophan had the opposite effect on mdr1 and mdr3 for actinomycin D resistance, causing either a 3-fold increase or a 4-8-fold decrease in resistance to this drug, respectively.	Aspartic Acid	43-56	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	136-140
8103679-8	1993	While introducing tyrosine, tryptophan, or aspartic acid caused an almost complete loss of colchicine and adriamycin resistance in both mdr1 and mdr3, the replacement to tyrosine or tryptophan had the opposite effect on mdr1 and mdr3 for actinomycin D resistance, causing either a 3-fold increase or a 4-8-fold decrease in resistance to this drug, respectively.	Aspartic Acid	43-56	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	145-149
8103679-8	1993	While introducing tyrosine, tryptophan, or aspartic acid caused an almost complete loss of colchicine and adriamycin resistance in both mdr1 and mdr3, the replacement to tyrosine or tryptophan had the opposite effect on mdr1 and mdr3 for actinomycin D resistance, causing either a 3-fold increase or a 4-8-fold decrease in resistance to this drug, respectively.	Aspartic Acid	43-56	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	220-224
8103679-8	1993	While introducing tyrosine, tryptophan, or aspartic acid caused an almost complete loss of colchicine and adriamycin resistance in both mdr1 and mdr3, the replacement to tyrosine or tryptophan had the opposite effect on mdr1 and mdr3 for actinomycin D resistance, causing either a 3-fold increase or a 4-8-fold decrease in resistance to this drug, respectively.	Aspartic Acid	43-56	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	229-233
8239523-6	1993	The activity of purified GST towards 1-chloro-2,4-dinitrobenzene (CDNB) was inhibited in a dose dependent manner by ascorbyl esters (I-50 = 27.5 microM As-S and 56.0 microM As-P) but not by rHuIFN-a2b.	Aspartic Acid	173-177	glutathione S-transferase kappa 1	Homo sapiens	25-28
8259556-1	1993	Recombinant staphylokinase (STAR) is produced as a 136 amino acid protein with NH2-terminal sequence Ser-Ser-Ser (mature STAR, HMW-STAR), which may be converted to lower molecular weight forms (LMW-STAR) by removal of the first six residues (yielding STAR-delta 6 with NH2-terminal Gly-Lys-Tyr-) or the first ten residues (yielding STAR-delta 10 with NH2-terminal Lys-Gly-Asp-).	Aspartic Acid	372-375	steroidogenic acute regulatory protein	Homo sapiens	28-32
8370581-2	1993	In this variant a single amino acid substitution (alanine to aspartic acid) occurred at position 972 of the spectrin alpha-chain due to a point mutation (GCT to GAT) in the DNA.	Aspartic Acid	61-74	glycine-N-acyltransferase	Homo sapiens	161-164
7690067-0	1993	Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus.	Aspartic Acid	0-9	carbonic anhydrase 1	Rattus norvegicus	73-76
7690067-1	1993	We examined whether L-aspartate (ASP) and L-glutamate (GLU) both function as endogenous neurotransmitters in area CA1 of the rat hippocampus.	Aspartic Acid	20-31	carbonic anhydrase 1	Rattus norvegicus	114-117
7690067-1	1993	We examined whether L-aspartate (ASP) and L-glutamate (GLU) both function as endogenous neurotransmitters in area CA1 of the rat hippocampus.	Aspartic Acid	33-36	carbonic anhydrase 1	Rattus norvegicus	114-117
7690067-9	1993	Together, these results confirm that ASP and GLU are both involved in excitatory synaptic transmission at the Schaffer collateral-commissural terminals in area CA1 of the rat hippocampus.	Aspartic Acid	37-40	carbonic anhydrase 1	Rattus norvegicus	160-163
8259556-1	1993	Recombinant staphylokinase (STAR) is produced as a 136 amino acid protein with NH2-terminal sequence Ser-Ser-Ser (mature STAR, HMW-STAR), which may be converted to lower molecular weight forms (LMW-STAR) by removal of the first six residues (yielding STAR-delta 6 with NH2-terminal Gly-Lys-Tyr-) or the first ten residues (yielding STAR-delta 10 with NH2-terminal Lys-Gly-Asp-).	Aspartic Acid	372-375	cilia and flagella associated protein 97	Homo sapiens	127-130
8264574-2	1993	Especially the synthetic peptide pyroGlu-Asp-Asp-Ser-Asp-Glu-Glu-Asn comprising the carboxy-terminal acidic hepta-peptide of the largest subunit of RNA polymerase II was found to serve as an excellent substrate for purified CKII.	Aspartic Acid	41-44	casein kinase 2 alpha 1	Homo sapiens	224-228
8349684-2	1993	Sequence information from tryptic and Asp.N peptides on the isolated 20-kDa (p20) and a 10-kDa (p10) proteins enabled the subsequent cloning of ICE (Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Elliston, K. O., Ayala, J. M., Casano, F. J., Chin, J., Ding, G. J.-F., Egger, L. A., Gaffney, E. P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T.-T., Lee, T. D., Shively, J. E., MacCross, M., Mumford, R. A., Schmidt, J.	Aspartic Acid	38-41	caspase 1	Homo sapiens	144-147
8344916-8	1993	The difference between pI 6.0 L-FABP and pI 7.0 L-FABP was attributed to an asparagine-aspartate exchange at position 105.	Aspartic Acid	87-96	fatty acid binding protein 1	Bos taurus	30-36
8102366-0	1993	Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26).	Aspartic Acid	30-43	dipeptidylpeptidase 4	Mus musculus	108-131
8102366-0	1993	Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26).	Aspartic Acid	30-43	dipeptidylpeptidase 4	Mus musculus	133-137
8344429-4	1993	These reciprocal phosphorylation experiments (i) indicate that Ser11 of tobacco PEPC is the likely target residue, situated in the plant-invariant Glu/Asp-Lys/Arg-X-X-Ser phosphorylation motif near the N-terminus, and (ii) lend support to the recent hypothesis that C3-leaf PEPC is subject to regulatory phosphorylation in vivo.	Aspartic Acid	151-154	phosphoenolpyruvate carboxylase	Nicotiana tabacum	80-84
8344429-4	1993	These reciprocal phosphorylation experiments (i) indicate that Ser11 of tobacco PEPC is the likely target residue, situated in the plant-invariant Glu/Asp-Lys/Arg-X-X-Ser phosphorylation motif near the N-terminus, and (ii) lend support to the recent hypothesis that C3-leaf PEPC is subject to regulatory phosphorylation in vivo.	Aspartic Acid	151-154	phosphoenolpyruvate carboxylase	Nicotiana tabacum	274-278
8344916-8	1993	The difference between pI 6.0 L-FABP and pI 7.0 L-FABP was attributed to an asparagine-aspartate exchange at position 105.	Aspartic Acid	87-96	fatty acid binding protein 1	Bos taurus	48-54
8264574-2	1993	Especially the synthetic peptide pyroGlu-Asp-Asp-Ser-Asp-Glu-Glu-Asn comprising the carboxy-terminal acidic hepta-peptide of the largest subunit of RNA polymerase II was found to serve as an excellent substrate for purified CKII.	Aspartic Acid	45-48	casein kinase 2 alpha 1	Homo sapiens	224-228
8264574-2	1993	Especially the synthetic peptide pyroGlu-Asp-Asp-Ser-Asp-Glu-Glu-Asn comprising the carboxy-terminal acidic hepta-peptide of the largest subunit of RNA polymerase II was found to serve as an excellent substrate for purified CKII.	Aspartic Acid	45-48	casein kinase 2 alpha 1	Homo sapiens	224-228
15335687-3	1993	Curiously, the mammalian protease PC2, a Kex2 homolog that is likely to be required for pro-insulin processing, has an aspartate in place of asparagine at the "oxyanion hole".	Aspartic Acid	119-128	proprotein convertase subtilisin/kexin type 2	Homo sapiens	34-37
8360880-4	1993	Ser-205, along with His-43 and Asp-99 make up the catalytic triad within the active site of thrombin.	Aspartic Acid	31-34	coagulation factor II, thrombin	Homo sapiens	92-100
8344949-2	1993	Since BAP begins at the aspartate residue (Asp1, or codon 672 of the amyloid precursor protein (APP)770 transcript), the ability of several proteases to cleave the peptide bond methionine-Asp1 (M/D) was evaluated by using peptides and recombinant APP molecules as substrates.	Aspartic Acid	24-33	beta-secretase 2	Homo sapiens	43-47
8344949-5	1993	Peptide SEVNLDAEF, representing the mutation found in early onset Alzheimer"s disease families from Sweden, is cleaved by cathepsin G and chymotrypsin at leucine-aspartate (L/D).	Aspartic Acid	162-171	cathepsin G	Homo sapiens	122-133
15335687-3	1993	Curiously, the mammalian protease PC2, a Kex2 homolog that is likely to be required for pro-insulin processing, has an aspartate in place of asparagine at the "oxyanion hole".	Aspartic Acid	119-128	kexin KEX2	Saccharomyces cerevisiae S288C	41-45
15335687-9	1993	We found that, with three peptides that are good substrates of wild-type Kex2, the k(cal) of the Asp 314 enzyme was reduced approximately 4500-fold and its K(M) approximately 4-fold, relative to the wild-type enzyme.	Aspartic Acid	97-100	kexin KEX2	Saccharomyces cerevisiae S288C	73-77
15335687-13	1993	Aspartate at the oxyanion hole appears to confer k(caf) discrimination between substrates by raising the energy barrier for productive substrate binding: this may have implications for pro-insulin processing by the PC2 protease, which has an aspartate at the equivalent position.	Aspartic Acid	0-9	proprotein convertase subtilisin/kexin type 2	Homo sapiens	215-218
15335687-13	1993	Aspartate at the oxyanion hole appears to confer k(caf) discrimination between substrates by raising the energy barrier for productive substrate binding: this may have implications for pro-insulin processing by the PC2 protease, which has an aspartate at the equivalent position.	Aspartic Acid	242-251	proprotein convertase subtilisin/kexin type 2	Homo sapiens	215-218
8244418-6	1993	Both MAbs retained about 55% reactivity with the ET-1 terminal sequence of Asp-Ile-Ile-Trp (ET18-21) but had no reactivity with the ET sequence His-Leu-Asp-Ile-Ile-Trp-Val-Asn (ET16-23) nor with Big ET-1 (ET1-39).	Aspartic Acid	75-78	endothelin 1	Homo sapiens	49-53
8400548-1	1993	Previous studies have shown that exogenous glycosphingolipids (GSLs) inhibit the adhesion of thrombin-activated platelets (TAP) to polystyrene plates coated with various RGD-ligands (where RGD is the peptide sequence Arg-Gly-Asp), suggesting that GSLs can modulate the platelet integrin receptor glycoprotein IIb-IIIa.	Aspartic Acid	225-228	coagulation factor II, thrombin	Bos taurus	93-101
8345056-4	1993	Analysis of her P450c17 gene by polymerase chain reaction amplification and sequencing showed a nine-base deletion, eliminating codons 487-489 (Asp-Ser-Phe) near the carboxy-terminus of P450c17.	Aspartic Acid	144-147	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	16-23
7688476-6	1993	Over-expression of chimeric insulin receptors containing the c-erbB-2 TM domain or a single point mutation in the insulin receptor TM domain of Val-938--&gt;Asp, on the other hand, shows none of these alterations.	Aspartic Acid	157-160	insulin	Cricetulus griseus	28-35
8350871-5	1993	The results of the mutagenesis showed that changing a single light chain residue, VL 91, from glycine to aspartic acid, resulted in a dramatic loss of Ars binding activity.	Aspartic Acid	105-118	secreted Ly6/Plaur domain containing 1	Mus musculus	151-154
7688476-6	1993	Over-expression of chimeric insulin receptors containing the c-erbB-2 TM domain or a single point mutation in the insulin receptor TM domain of Val-938--&gt;Asp, on the other hand, shows none of these alterations.	Aspartic Acid	157-160	insulin receptor	Cricetulus griseus	28-44
8343162-2	1993	Sequencing analysis revealed an A to G transition at codon 778 leading to replacement of the Asp residue, which is adjacent to the interaction sites of myosin heavy chain (MHC) with actin and is a conserved amino acid residue in various MHC across species, to the Gly residue.	Aspartic Acid	93-96	major histocompatibility complex, class I, C	Homo sapiens	152-170
8343162-2	1993	Sequencing analysis revealed an A to G transition at codon 778 leading to replacement of the Asp residue, which is adjacent to the interaction sites of myosin heavy chain (MHC) with actin and is a conserved amino acid residue in various MHC across species, to the Gly residue.	Aspartic Acid	93-96	major histocompatibility complex, class I, C	Homo sapiens	172-175
8343162-2	1993	Sequencing analysis revealed an A to G transition at codon 778 leading to replacement of the Asp residue, which is adjacent to the interaction sites of myosin heavy chain (MHC) with actin and is a conserved amino acid residue in various MHC across species, to the Gly residue.	Aspartic Acid	93-96	major histocompatibility complex, class I, C	Homo sapiens	237-240
8333874-5	1993	The proposed CCK "B-conformation" has a distorted beta-III turn at the C-terminal Gly-Trp-Met-Asp fragment, the Phe33 residue and the C-terminal amide being directed outward from the turn.	Aspartic Acid	94-97	cholecystokinin B receptor	Homo sapiens	13-19
8393341-4	1993	NPK forms a regular amphipathic alpha-helical structure from Asp 3, terminating at Gly 18.	Aspartic Acid	61-64	tachykinin precursor 1	Homo sapiens	0-3
8325838-3	1993	We demonstrate using flow cytometric methods a central role for the beta 3 integrin glycoprotein (GP) IIb-IIIa complex and its ligand tetrapeptide Arg-Gly-Asp-Ser (RGDS) binding site in platelet vesiculation.	Aspartic Acid	155-158	ral guanine nucleotide dissociation stimulator	Homo sapiens	164-168
8369172-5	1993	These effects mapped to a different region from the trans-activation domain of Tat, as mutating the RGD (arginine-glycine-aspartic acid) sequence within the second exon abrogated aggregation and fascicle formation without affecting trans-activation capacity.	Aspartic Acid	122-135	tyrosine aminotransferase	Homo sapiens	79-82
8317498-0	1993	Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy) A search for mutations in the gene for type II procollagen (COL2A1) was carried out in affected members of a family with early-onset cataracts, lattice degeneration of the retina, and retinal detachment.	Aspartic Acid	58-67	collagen type II alpha 1 chain	Homo sapiens	33-39
8392065-10	1993	Mutation of serine 51 to glycine (S51G) or to aspartic acid (S51D), as well as altering the basic residues flanking serine 51, abolished the interaction of hVDR with the vitamin D-responsive element (VDRE) as monitored by gel mobility shift analysis.	Aspartic Acid	46-59	vitamin D receptor	Homo sapiens	156-160
8329399-3	1993	When GTP gamma S is substituted for GDP in cellular N-ras p21, the chemical shifts of resonances Asp-47, -126, -154, and Asn-172, as well as Gly-77 and -151, are not sensitive to nucleotide exchange, whereas Asp-30, -33, -38, -54, -57, -69, -92, -105, and -119 are affected.	Aspartic Acid	97-100	NRAS proto-oncogene, GTPase	Homo sapiens	52-57
8329399-3	1993	When GTP gamma S is substituted for GDP in cellular N-ras p21, the chemical shifts of resonances Asp-47, -126, -154, and Asn-172, as well as Gly-77 and -151, are not sensitive to nucleotide exchange, whereas Asp-30, -33, -38, -54, -57, -69, -92, -105, and -119 are affected.	Aspartic Acid	97-100	H3 histone pseudogene 16	Homo sapiens	58-61
8329399-3	1993	When GTP gamma S is substituted for GDP in cellular N-ras p21, the chemical shifts of resonances Asp-47, -126, -154, and Asn-172, as well as Gly-77 and -151, are not sensitive to nucleotide exchange, whereas Asp-30, -33, -38, -54, -57, -69, -92, -105, and -119 are affected.	Aspartic Acid	208-211	NRAS proto-oncogene, GTPase	Homo sapiens	52-57
8329399-3	1993	When GTP gamma S is substituted for GDP in cellular N-ras p21, the chemical shifts of resonances Asp-47, -126, -154, and Asn-172, as well as Gly-77 and -151, are not sensitive to nucleotide exchange, whereas Asp-30, -33, -38, -54, -57, -69, -92, -105, and -119 are affected.	Aspartic Acid	208-211	H3 histone pseudogene 16	Homo sapiens	58-61
8323294-5	1993	Like the other vertebrate SCPx proteins, the chicken protein contains a conserved Arg-Gly-Asp sequence and a cysteine residue in the N-terminus that aligns with the active site cysteine of Escherichia coli 3-ketoacyl-CoA thiolase, a protein that was previously shown to be homologous to vertebrate SCPx.	Aspartic Acid	90-93	sterol carrier protein 2	Gallus gallus	26-30
8405897-6	1993	The sequence His-Ala-Asp-Gly-Thr5-Phe-Thr-Asn-Asp-Met10-Thr-Ser-Tyr- Leu-Asp15-Ala-Lys-Ala-Ala-Arg20-Asp-Phe-Val-Ser-Trp25- Leu-Ala-Arg-Ser-Asp30- Lys-Ser shows 16 amino acid substitutions compared with the corresponding region of mammalian GLP-1 and 15 substitutions compared with that of salmon GLP.	Aspartic Acid	21-24	glucagon like peptide 1 receptor	Homo sapiens	241-246
8320232-9	1993	AatB expressed in E. coli has a Km for aspartate of 5.3 mM and a Km for 2-oxoglutarate of 0.87 mM.	Aspartic Acid	39-48	AatB	Escherichia coli	0-4
8364576-6	1993	Sequencing of the liver FAH cDNA of the patient revealed a C to A transversion in the FAH mRNA, which predicted the replacement of an alanine (A) residue with an aspartic acid (D) residue at position 134 (A134D) of the amino acid sequence of the corresponding protein.	Aspartic Acid	162-175	fumarylacetoacetate hydrolase	Homo sapiens	24-27
8364576-6	1993	Sequencing of the liver FAH cDNA of the patient revealed a C to A transversion in the FAH mRNA, which predicted the replacement of an alanine (A) residue with an aspartic acid (D) residue at position 134 (A134D) of the amino acid sequence of the corresponding protein.	Aspartic Acid	162-175	fumarylacetoacetate hydrolase	Homo sapiens	86-89
8361487-0	1993	[Calorimetric studies of the effect of amino acid replacements 16Gln-Leu and 26Tyr-Asp on the structural organization and stability of the Cro-repressor from phage lambda].	Aspartic Acid	83-86	cro	Escherichia virus Lambda	139-142
8332461-8	1993	EF-Gmt differs from its cytoplasmic homolog, EF-2, in that it contains an aspartic acid residue at amino acid position 621 which corresponds to the EF-2 histidine residue at position 715.	Aspartic Acid	74-87	G elongation factor, mitochondrial 1	Rattus norvegicus	0-6
7686366-6	1993	Occupancy of glycoprotein IIb-IIIa in the membranes with RGD (Arg-Gly-Asp)-containing peptides reversibly exposed neoantigenic epitopes and fibrinogen-binding sites in the receptor.	Aspartic Acid	70-73	fibrinogen beta chain	Homo sapiens	140-150
8514788-10	1993	Furthermore, the cysteine-rich segment of linker chain L1 has the sequence Asp-Gly-Ser-Asp-Glu which is characteristic of LDL receptor repeats.	Aspartic Acid	75-78	low density lipoprotein receptor	Homo sapiens	122-134
8514788-10	1993	Furthermore, the cysteine-rich segment of linker chain L1 has the sequence Asp-Gly-Ser-Asp-Glu which is characteristic of LDL receptor repeats.	Aspartic Acid	87-90	low density lipoprotein receptor	Homo sapiens	122-134
8099556-3	1993	Here, we have systematically substituted potential metal-coordinating amino acid residues (His, Glu, Asp, Cys, Tyr, Ser) for each of the three zinc ligands of NEP using a recombinant polymerase chain reaction procedure.	Aspartic Acid	101-104	membrane metalloendopeptidase	Homo sapiens	159-162
8332461-8	1993	EF-Gmt differs from its cytoplasmic homolog, EF-2, in that it contains an aspartic acid residue at amino acid position 621 which corresponds to the EF-2 histidine residue at position 715.	Aspartic Acid	74-87	eukaryotic translation elongation factor 2	Rattus norvegicus	45-49
8505327-6	1993	Essentially this same value was determined for the r-mutants, [Gla7--&gt;Asp]r-PC and [Gln32--&gt;Gla]r-PC.	Aspartic Acid	73-76	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	79-81
8266745-3	1993	Recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate aminotransferase (AAT) and malate dehydrogenase (MDH) (Fisher 1990a; Fisher 1990b; Bennett and Fisher, 1990): aspartate + alpha-ketoglutamate &lt;--&gt; glutamate + oxaloacetate; oxaloacetate + NADH &lt;--&gt; malate + NAD.	Aspartic Acid	158-167	malic enzyme 1	Homo sapiens	195-215
8266745-3	1993	Recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate aminotransferase (AAT) and malate dehydrogenase (MDH) (Fisher 1990a; Fisher 1990b; Bennett and Fisher, 1990): aspartate + alpha-ketoglutamate &lt;--&gt; glutamate + oxaloacetate; oxaloacetate + NADH &lt;--&gt; malate + NAD.	Aspartic Acid	158-167	malic enzyme 1	Homo sapiens	217-220
8505327-7	1993	An approximate 2-fold lower C50-PC was obtained for [Gla14--&gt;Asp]r-PC (0.14 microM), [Gla25--&gt;Asp]r-PC (0.16 microM), and [Gla29--&gt;Asp]r-PC (0.15 microM).	Aspartic Acid	64-67	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	32-34
8505327-7	1993	An approximate 2-fold lower C50-PC was obtained for [Gla14--&gt;Asp]r-PC (0.14 microM), [Gla25--&gt;Asp]r-PC (0.16 microM), and [Gla29--&gt;Asp]r-PC (0.15 microM).	Aspartic Acid	64-67	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	70-72
8505327-7	1993	An approximate 2-fold lower C50-PC was obtained for [Gla14--&gt;Asp]r-PC (0.14 microM), [Gla25--&gt;Asp]r-PC (0.16 microM), and [Gla29--&gt;Asp]r-PC (0.15 microM).	Aspartic Acid	64-67	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	70-72
8505327-7	1993	An approximate 2-fold lower C50-PC was obtained for [Gla14--&gt;Asp]r-PC (0.14 microM), [Gla25--&gt;Asp]r-PC (0.16 microM), and [Gla29--&gt;Asp]r-PC (0.15 microM).	Aspartic Acid	64-67	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	70-72
8505327-7	1993	An approximate 2-fold lower C50-PC was obtained for [Gla14--&gt;Asp]r-PC (0.14 microM), [Gla25--&gt;Asp]r-PC (0.16 microM), and [Gla29--&gt;Asp]r-PC (0.15 microM).	Aspartic Acid	100-103	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	32-34
8505327-7	1993	An approximate 2-fold lower C50-PC was obtained for [Gla14--&gt;Asp]r-PC (0.14 microM), [Gla25--&gt;Asp]r-PC (0.16 microM), and [Gla29--&gt;Asp]r-PC (0.15 microM).	Aspartic Acid	100-103	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	32-34
8099118-15	1993	At entry, serum activities of aspartate and alanine aminotransferases correlated to plasma insulin concentration independent of body mass index.	Aspartic Acid	30-39	insulin	Homo sapiens	91-98
8512325-6	1993	Porcine thymus HMG-17 differs from the human protein by only a single conservative substitution at position 64 (aspartic acid instead of glutamic acid).	Aspartic Acid	112-125	high mobility group nucleosomal binding domain 2	Homo sapiens	15-21
8330973-0	1993	Hb Volga [beta 27(B9)Ala-->Asp]: detection of a de novo mutation by Ava II digestion of PCR-amplified DNA.	Aspartic Acid	27-30	B9 domain containing 1	Homo sapiens	3-20
7687269-6	1993	The channels are anion selective with a permeability sequence of I- &gt; SCN- &gt; NO3-, Br- &gt; Cl- &gt; MeSO3- &gt; acetate, propionate &gt; ascorbate &gt; aspartate and gluconate.	Aspartic Acid	159-168	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
8394319-4	1993	Further analyses of the results with cyanogen bromide and protease digestion suggest that the probable site of DCCD binding is aspartate 160 of yeast cytochrome b and aspartate 155 or glutamate 166 of spinach cytochrome b6.	Aspartic Acid	127-136	cytochrome b	Saccharomyces cerevisiae S288C	150-162
8347568-2	1993	The modeling suggested that the structure of TAR was similar to that of the anti-codon loop of tRNA(Asp), having a loop of just three single-stranded residues with a mismatched adenine excluded from the helical stem on the 3" side of the loop.	Aspartic Acid	100-103	RNA binding motif protein 8A	Homo sapiens	45-48
8506360-2	1993	To determine whether this aspartic acid is also involved in the function of the rat vascular angiotensin II receptor subtype 1 (AT1a), Asp74 was replaced either by asparagine or by glutamic acid.	Aspartic Acid	26-39	angiotensinogen	Rattus norvegicus	93-107
8503189-4	1993	To further explore the mechanism by which the Gag-Pol polyprotein is incorporated into virions, we have constructed a mutation which changes an aspartic acid in the protease active site to asparagine (pHXB2pro-); a four-amino-acid insertion into the protease gene (pHXB2Smal); and insertion of translational termination codons in the protease gene following the gag gene (pHXB55).	Aspartic Acid	144-157	Pr55(Gag)	Human immunodeficiency virus 1	46-49
8506386-3	1993	After activation of this zymogen to its corresponding form of the serine protease plasmin (MrhPm), this latter enzyme was essentially inactive toward an amide plasmin substrate, most likely from alteration of the spatial relationships of the active-site His-603 to its partners of the catalytic triad, Asp-646 and Ser-741.	Aspartic Acid	302-305	plasminogen	Homo sapiens	82-89
8499451-6	1993	Mutation of the two asparagine carbohydrate linkage sites to aspartic acid residues led to the expression and secretion of up to 25 mg/L nonglycosylated transferrin.	Aspartic Acid	61-74	transferrin	Homo sapiens	153-164
8486712-1	1993	To determine the functional conformation of the Arg-Gly-Asp (RGD) sequence, we have constructed mutant proteins by inserting 4-12 amino acid residues from the RGD region of human fibronectin between Val74 and Asn75 of human lysozyme.	Aspartic Acid	56-59	fibronectin 1	Homo sapiens	179-190
8481514-4	1993	Analysis of the genes for two other components of the platelet GPIb:IX complex, namely GPIb beta and GPIX, showed two different missense mutations in the coding region of the GPIX gene: an A-->G transition in codon 21 results in conversion of an aspartic acid to glycine and an A-->G change in codon 45 converts an asparagine residue to serine.	Aspartic Acid	246-259	glycoprotein Ib platelet subunit alpha	Homo sapiens	87-96
7683657-0	1993	Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesion.	Aspartic Acid	50-63	vitronectin	Homo sapiens	67-78
7683657-3	1993	Many cell adhesion ligands, including vitronectin, contain an Arg-Gly-Asp (RGD) sequence mediating, in part, the ligand-receptor interaction.	Aspartic Acid	70-73	vitronectin	Homo sapiens	38-49
8485125-0	1993	Intravenous and endobronchial administration of G4120, a cyclic Arg-Gly-Asp-containing platelet GPIIb/IIIa receptor-blocking pentapeptide, enhances and sustains coronary arterial thrombolysis with rt-PA in a canine preparation.	Aspartic Acid	72-75	integrin subunit alpha 2b	Canis lupus familiaris	96-101
8481514-4	1993	Analysis of the genes for two other components of the platelet GPIb:IX complex, namely GPIb beta and GPIX, showed two different missense mutations in the coding region of the GPIX gene: an A-->G transition in codon 21 results in conversion of an aspartic acid to glycine and an A-->G change in codon 45 converts an asparagine residue to serine.	Aspartic Acid	246-259	glycoprotein IX platelet	Homo sapiens	101-105
8481514-4	1993	Analysis of the genes for two other components of the platelet GPIb:IX complex, namely GPIb beta and GPIX, showed two different missense mutations in the coding region of the GPIX gene: an A-->G transition in codon 21 results in conversion of an aspartic acid to glycine and an A-->G change in codon 45 converts an asparagine residue to serine.	Aspartic Acid	246-259	glycoprotein IX platelet	Homo sapiens	175-179
8491712-3	1993	Downstream of pbpE there was a second gene, termed orf2, which exhibited sequence similarity with aspartate racemase.	Aspartic Acid	98-107	hypothetical protein	Bacillus subtilis	51-55
8097406-9	1993	In contrast, Asp-125-hrDP and Cys-125hrDP were found to be inactive (&lt; or = 0.1% of wild-type enzyme).	Aspartic Acid	13-16	dipeptidase 1	Homo sapiens	21-25
8320368-7	1993	The 60 kDa protein was found to be bovine osteopontin, a very highly phosphorylated protein with an Arg-Gly-Asp sequence which mediates cell attachment.	Aspartic Acid	108-111	secreted phosphoprotein 1	Bos taurus	42-53
8386269-8	1993	Alteration of S-313 to an aspartate resulted in a form of LMP-1 that was toxic to Rat-1 cells.	Aspartic Acid	26-35	PDZ and LIM domain 7	Homo sapiens	58-63
8332551-5	1993	In addition, the gamma-MSH sequence, contrary to salmon POMC, is present and contains three substitutions, namely a Ser, an Asn, and a Lys residue substituting the normally occurring mammalian Gly, Asp, and Arg residue, respectively.	Aspartic Acid	198-201	proopiomelanocortin	Homo sapiens	17-26
8473297-3	1993	Non-conservative mutations of Lys-893 (K893I) and Asp-993 (D993A) completely inactivate human PARP, whereas conservative and nonconservative mutations of Asp-914 (D914E and D914A, respectively) and Lys-953 (K953R and K953I, respectively) partially alter PARP activity.	Aspartic Acid	50-53	poly(ADP-ribose) polymerase 1	Homo sapiens	94-98
8473297-4	1993	The consequences of conservative substitution of Lys-893 and Asp-993 on the kinetic properties of human poly(ADP-ribose) polymerase enzyme and the polymer it synthesizes suggest that these 2 amino acids are directly involved in the covalent attachment of the first ADP-ribosyl residue from NAD+ onto the acceptor amino acid.	Aspartic Acid	61-64	poly(ADP-ribose) polymerase 1	Homo sapiens	104-131
8491783-6	1993	The synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro, that contains the Arg-Gly-Asp (RGD) integrin recognition site, reversibly inhibited entactin-mediated blastocyst outgrowth in a dose-dependent manner, but had no effect on laminin-mediated outgrowth.	Aspartic Acid	35-38	nidogen 1	Mus musculus	132-140
8491783-8	1993	Furthermore, a mutated recombinant entactin, altered to contain a Glu in place of Asp at the RGD site, provided no trophoblast cell adhesive activity.	Aspartic Acid	82-85	nidogen 1	Mus musculus	35-43
7683462-0	1993	The cell attachment and spreading activity of vitronectin is dependent on the Arg-Gly-Asp sequence.	Aspartic Acid	86-89	vitronectin	Homo sapiens	46-57
7683462-2	1993	The cell attachment activity of vitronectin has been ascribed to an Arg-Gly-Asp (RGD) sequence near the amino terminus.	Aspartic Acid	76-79	vitronectin	Homo sapiens	32-43
8461464-1	1993	Divalent cation-dependent platelet adhesion to fibronectin (FN) is mediated by the integrin receptors alpha 5 beta 1 (GP Ic-IIa) and alpha IIb beta 3 (GP IIb-IIIa), which recognize the RGD (Arg-Gly-Asp) sequence in the cell-binding domain.	Aspartic Acid	198-201	fibronectin 1	Homo sapiens	47-58
8385482-1	1993	The involvement of specific aspartic acid (D) and glutamic acid (E) residues of the recombinant (r) kringle 2 (K2) domain of tissue-type plasminogen activator (tPA) in stabilizing its interaction with omega-amino acid ligands has been assessed by examination of these binding events subsequent to site-directed mutagenesis of the relevant amino acid residues.	Aspartic Acid	28-41	plasminogen activator, tissue type	Homo sapiens	125-158
8466356-8	1993	Stroke work index for hearts reperfused with aspartate/glutamate-enriched perfluorochemical cardioplegia was 19.8 +/- 1.6 x 10(3) erg/g, significantly increased over that of the nonenriched perfluorochemical group (p &lt; 0.01) and not different from values obtained in controls (19.2 +/- 0.8 x 10(3) erg/g).	Aspartic Acid	45-54	ETS transcription factor ERG	Homo sapiens	130-133
8466356-8	1993	Stroke work index for hearts reperfused with aspartate/glutamate-enriched perfluorochemical cardioplegia was 19.8 +/- 1.6 x 10(3) erg/g, significantly increased over that of the nonenriched perfluorochemical group (p &lt; 0.01) and not different from values obtained in controls (19.2 +/- 0.8 x 10(3) erg/g).	Aspartic Acid	45-54	ETS transcription factor ERG	Homo sapiens	301-304
8461309-0	1993	How do mutations at phenylalanine-153 and isoleucine-155 partially suppress the effects of the aspartate-27--&gt;serine mutation in Escherichia coli dihydrofolate reductase?	Aspartic Acid	95-104	Dihydrofolate reductase	Escherichia coli	149-172
8461464-1	1993	Divalent cation-dependent platelet adhesion to fibronectin (FN) is mediated by the integrin receptors alpha 5 beta 1 (GP Ic-IIa) and alpha IIb beta 3 (GP IIb-IIIa), which recognize the RGD (Arg-Gly-Asp) sequence in the cell-binding domain.	Aspartic Acid	198-201	fibronectin 1	Homo sapiens	60-62
8458843-8	1993	Like UhpA as a response regulator of a bacterial two-component regulatory system, ORF2 contained a helix-turn-helix DNA-binding domain at its COOH-terminal portion and an Asp residue (Asp-54) probably to be phosphorylated at its NH2-terminal portion.	Aspartic Acid	171-174	hypothetical protein	Escherichia coli	82-86
8096183-2	1993	We have recently reported that streptavidin contains an Arg-Tyr-Asp-Ser (RYDS) sequence which exhibits structural homology to the Arg-Gly-Asp-Ser (RGDS) cell adhesion domain of fibronectin and other matrix-associated glycoproteins.	Aspartic Acid	64-67	fibronectin 1	Homo sapiens	177-188
21573584-9	1993	None of the tumors had mutations in K-ras codons 12 or 13 (Gly--&gt;Asp) It is suggested that the ras p21 oncoprotein may be involved in the pathogenesis and H-ras mutations and be a molecular genetic marker in small intestinal tumors.	Aspartic Acid	68-71	H3 histone pseudogene 16	Homo sapiens	102-105
8458843-8	1993	Like UhpA as a response regulator of a bacterial two-component regulatory system, ORF2 contained a helix-turn-helix DNA-binding domain at its COOH-terminal portion and an Asp residue (Asp-54) probably to be phosphorylated at its NH2-terminal portion.	Aspartic Acid	184-187	hypothetical protein	Escherichia coli	82-86
8362410-6	1993	In view of the published data on HLA class I nucleotide sequences, the antibody may recognize an antigeneic determinant including two amino acid residues, Asp-166 and Gly-167, in the alpha 2 helix of the class I molecule that are specific for A1, A23 and A24 so far analyzed.	Aspartic Acid	155-158	immunoglobulin kappa variable 2-24	Homo sapiens	247-250
8468356-7	1993	The peptide specifically inhibited binding of fibronectin to gelatin or type I collagen and inhibited fibronectin-mediated adhesion of breast carcinoma and melanoma cells to gelatin or type I collagen substrates but not direct adhesion of the cells to fibronectin, which was inhibited by the peptide Gly-Arg-Gly-Asp-Ser.	Aspartic Acid	312-315	fibronectin 1	Homo sapiens	46-57
8468356-7	1993	The peptide specifically inhibited binding of fibronectin to gelatin or type I collagen and inhibited fibronectin-mediated adhesion of breast carcinoma and melanoma cells to gelatin or type I collagen substrates but not direct adhesion of the cells to fibronectin, which was inhibited by the peptide Gly-Arg-Gly-Asp-Ser.	Aspartic Acid	312-315	fibronectin 1	Homo sapiens	102-113
8468356-7	1993	The peptide specifically inhibited binding of fibronectin to gelatin or type I collagen and inhibited fibronectin-mediated adhesion of breast carcinoma and melanoma cells to gelatin or type I collagen substrates but not direct adhesion of the cells to fibronectin, which was inhibited by the peptide Gly-Arg-Gly-Asp-Ser.	Aspartic Acid	312-315	fibronectin 1	Homo sapiens	102-113
8362410-6	1993	In view of the published data on HLA class I nucleotide sequences, the antibody may recognize an antigeneic determinant including two amino acid residues, Asp-166 and Gly-167, in the alpha 2 helix of the class I molecule that are specific for A1, A23 and A24 so far analyzed.	Aspartic Acid	155-158	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	255-258
8443166-9	1993	An important characteristic of the sequence is the presence of two adjacent aspartic acid residues (Asp117-Asp118) which most likely provide the negative charge environment for the sulfonium moiety of the AdoMet molecule.	Aspartic Acid	76-89	methionine adenosyltransferase 1A	Rattus norvegicus	205-211
8095159-4	1993	Substitution by Asp does not influence the rate of tRNA and rRNA degradation but alters specificity even more markedly than the other mutations: T44D-angiogenin has 17-40-fold decreased activity toward CpN" dinucleotides and 1.3-1.9-fold increased activity toward UpN", resulting in an inverted order of preference (U &gt; C) compared to native angiogenin.	Aspartic Acid	16-19	angiogenin	Homo sapiens	150-160
8440915-7	1993	The region of fibronectin recognized by alpha 5 beta 1 contains the amino acid sequence arg-gly-asp (RGD).	Aspartic Acid	96-99	fibronectin 1	Homo sapiens	14-25
8385060-4	1993	This method allows detection of aspartic acid mutations of the c-Ki-ras gene at codons 12 and 13.	Aspartic Acid	32-45	KRAS proto-oncogene, GTPase	Homo sapiens	63-71
8444858-2	1993	An apparent exception to this observation is the CD3-epsilon chain of the T-cell antigen receptor complex, which is relatively stable in spite of having a transmembrane aspartic acid residue.	Aspartic Acid	169-182	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	49-60
8384827-0	1993	Importance of the Arg-Gly-Asp triplet in human thrombin for maintenance of structure and function.	Aspartic Acid	26-29	coagulation factor II, thrombin	Homo sapiens	47-55
8384827-1	1993	Site-directed mutagenesis was employed to assess the importance of the Arg-Gly-Asp triplet that comprises residues 197 to 199 in the B-chain of thrombin.	Aspartic Acid	79-82	coagulation factor II, thrombin	Homo sapiens	144-152
8384830-6	1993	Comparison with sequences of other cytochromes c indicated the closest similarity to cytochrome c from snapping turtle (Chelydra serpentina) with substitutions at five positions corresponding to residues 32 (His--&gt;Asn), 44 (Glu--&gt;Pro), 89 (Ala--&gt;Pro), 100 (Asp--&gt;Glu), and 104 (Lys--&gt;Asn), respectively.	Aspartic Acid	266-269	cytochrome c	Alligator mississippiensis	85-97
8471719-12	1993	The results of simulations of several alanine based 46 residue polypeptides with some of the charged residues present in the Pf1 coat protein sequence suggest that interactions between the Asp 14 and Asp 18 sidechains and the peptide backbone are responsible for the formation of the mobile loop.	Aspartic Acid	189-192	PHD finger protein 12	Homo sapiens	125-128
8471719-12	1993	The results of simulations of several alanine based 46 residue polypeptides with some of the charged residues present in the Pf1 coat protein sequence suggest that interactions between the Asp 14 and Asp 18 sidechains and the peptide backbone are responsible for the formation of the mobile loop.	Aspartic Acid	200-203	PHD finger protein 12	Homo sapiens	125-128
8462775-2	1993	It has been suggested that protection from disease may be conferred by HLA-DQB1 genes which encode molecules with aspartate at position 57.	Aspartic Acid	114-123	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	71-79
8462775-6	1993	The DQB1 alleles DQB1*0303, DQB1*0602 and DQB1*0603 were associated with protection, as was DQB1*0604, which encodes an Asp-57 negative DQ beta molecule.	Aspartic Acid	120-123	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-8
8462775-6	1993	The DQB1 alleles DQB1*0303, DQB1*0602 and DQB1*0603 were associated with protection, as was DQB1*0604, which encodes an Asp-57 negative DQ beta molecule.	Aspartic Acid	120-123	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	17-21
8462775-6	1993	The DQB1 alleles DQB1*0303, DQB1*0602 and DQB1*0603 were associated with protection, as was DQB1*0604, which encodes an Asp-57 negative DQ beta molecule.	Aspartic Acid	120-123	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	17-21
8462775-6	1993	The DQB1 alleles DQB1*0303, DQB1*0602 and DQB1*0603 were associated with protection, as was DQB1*0604, which encodes an Asp-57 negative DQ beta molecule.	Aspartic Acid	120-123	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	17-21
8462775-6	1993	The DQB1 alleles DQB1*0303, DQB1*0602 and DQB1*0603 were associated with protection, as was DQB1*0604, which encodes an Asp-57 negative DQ beta molecule.	Aspartic Acid	120-123	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	17-21
7763526-3	1993	Structural analysis of the hydrogen bonding network around the two active site aspartates 32 and 215 in chymosin have suggested that residues Thr 218 and Asp 303 may influence the rate and pH optima for catalysis.	Aspartic Acid	79-89	chymosin	Bos taurus	104-112
7763526-3	1993	Structural analysis of the hydrogen bonding network around the two active site aspartates 32 and 215 in chymosin have suggested that residues Thr 218 and Asp 303 may influence the rate and pH optima for catalysis.	Aspartic Acid	154-157	chymosin	Bos taurus	104-112
8485574-4	1993	A base substitution was identified in the peripherin (RDS) gene and DNA sequencing revealed a G to A transition in codon 167 that substitutes aspartic acid for a highly conserved glycine.	Aspartic Acid	142-155	peripherin	Homo sapiens	42-52
8321419-1	1993	Glutamate and aspartate have been hypothesized to function as neurotransmitters in the regulation of the gonadotropin-releasing hormone (GnRH) neurosecretory system.	Aspartic Acid	14-23	Progonadoliberin-1	Ovis aries	105-135
8321419-1	1993	Glutamate and aspartate have been hypothesized to function as neurotransmitters in the regulation of the gonadotropin-releasing hormone (GnRH) neurosecretory system.	Aspartic Acid	14-23	Progonadoliberin-1	Ovis aries	137-141
8479597-1	1993	Since the malate-aspartate shuttle in brain has been shown to be closely linked to brain energy metabolism and neurotransmitter synthesis, the activity of MDH, one of the enzymes of the malate-aspartate shuttle, was studied in cortical non-synaptic mitochondria (mMDH) and cytosol (cMDH) in 1-4 day, 18-20 day and 7-8 week old rats.	Aspartic Acid	17-26	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	155-158
8479597-1	1993	Since the malate-aspartate shuttle in brain has been shown to be closely linked to brain energy metabolism and neurotransmitter synthesis, the activity of MDH, one of the enzymes of the malate-aspartate shuttle, was studied in cortical non-synaptic mitochondria (mMDH) and cytosol (cMDH) in 1-4 day, 18-20 day and 7-8 week old rats.	Aspartic Acid	193-202	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	155-158
8437218-4	1993	Mutants carrying Asn--&gt;Asp mutations at each of the two consensus signals for N-linked glycosylation in the N-terminal domain of SFFVAP-L env (gs1 and gs2), the gs1-2- double mutant, and the gs0 quadruple mutant (mutated at all four signals utilized for N-linked glycosylation in SFFVAP-L env) were made.	Aspartic Acid	26-29	endogenous retrovirus group W member 1, envelope	Homo sapiens	141-144
8485574-4	1993	A base substitution was identified in the peripherin (RDS) gene and DNA sequencing revealed a G to A transition in codon 167 that substitutes aspartic acid for a highly conserved glycine.	Aspartic Acid	142-155	peripherin 2	Homo sapiens	54-57
8479597-11	1993	The greater sensitivity of mMDH, compared to cMDH, to certain effectors may be related to the dual role of mMDH in the tricarboxylic acid cycle and the malate-aspartate shuttle.	Aspartic Acid	159-168	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	27-31
8425608-1	1993	Existence of a long-lived intermediate and the states of the carboxylic group of Asp-81 in rhodopsin and its photoproducts.	Aspartic Acid	81-84	rhodopsin	Homo sapiens	91-100
8490130-4	1993	The encoded protein most resembles the endoplasmic reticulum (ER) resident HSP90 protein, the 94 kDa glucose-regulated protein (GRP94) of vertebrates, as it possesses both the characteristic N-terminal domain including a signal peptide sequence and the C-terminal ER retention signal (Lys-Asp-Glu-Leu).	Aspartic Acid	289-292	HSP90	Hordeum vulgare	75-80
8381415-7	1993	In EGF4, which is essential for protein C activation by the thrombin-TM complex, critical residues were: Asp-349, Glu-357, Tyr-358, and Phe-376.	Aspartic Acid	105-108	coagulation factor II, thrombin	Homo sapiens	60-68
8381415-8	1993	In EGF5-EGF6, critical residues within a proposed acidic thrombin-binding region were: Glu-408, Tyr-413, Ile-414, Leu-415, Asp-416, Asp-417, Asp-423, Ile-424, Asp-425, and Glu-426.	Aspartic Acid	123-126	coagulation factor II, thrombin	Homo sapiens	57-65
8381415-8	1993	In EGF5-EGF6, critical residues within a proposed acidic thrombin-binding region were: Glu-408, Tyr-413, Ile-414, Leu-415, Asp-416, Asp-417, Asp-423, Ile-424, Asp-425, and Glu-426.	Aspartic Acid	132-135	coagulation factor II, thrombin	Homo sapiens	57-65
8381415-8	1993	In EGF5-EGF6, critical residues within a proposed acidic thrombin-binding region were: Glu-408, Tyr-413, Ile-414, Leu-415, Asp-416, Asp-417, Asp-423, Ile-424, Asp-425, and Glu-426.	Aspartic Acid	132-135	coagulation factor II, thrombin	Homo sapiens	57-65
8381415-8	1993	In EGF5-EGF6, critical residues within a proposed acidic thrombin-binding region were: Glu-408, Tyr-413, Ile-414, Leu-415, Asp-416, Asp-417, Asp-423, Ile-424, Asp-425, and Glu-426.	Aspartic Acid	132-135	coagulation factor II, thrombin	Homo sapiens	57-65
8381415-9	1993	A potential Ca(2+)-binding site, which is comprised of residues Asp-423, Asp-425, Glu-426, Asn-439, Leu-440, and Phe-444, was also identified and overlaps the thrombin-binding region.	Aspartic Acid	64-67	coagulation factor II, thrombin	Homo sapiens	159-167
8381415-9	1993	A potential Ca(2+)-binding site, which is comprised of residues Asp-423, Asp-425, Glu-426, Asn-439, Leu-440, and Phe-444, was also identified and overlaps the thrombin-binding region.	Aspartic Acid	73-76	coagulation factor II, thrombin	Homo sapiens	159-167
8381415-10	1993	Asp-461, in the C-loop of EGF6 previously shown to be critical for thrombin binding, was also critical.	Aspartic Acid	0-3	coagulation factor II, thrombin	Homo sapiens	67-75
8452235-1	1993	Recent experimental work on the mechanism of action of glycosylasparaginase suggests that the enzyme specifically reacts toward the L-asparagine or L-aspartic acid moiety of its substrates.	Aspartic Acid	148-163	aspartylglucosaminidase	Homo sapiens	55-75
8472268-8	1993	Elastin from dissected aortas had a higher content of aspartate, threonine, serine, glutamate, and lysine and a lower content of glycine, alanine, and valine than elastin from controls (p &lt; 0.05).	Aspartic Acid	54-63	elastin	Homo sapiens	0-7
8094613-0	1993	The conservative substitution Asp-645--&gt;Glu in lysosomal alpha-glucosidase affects transport and phosphorylation of the enzyme in an adult patient with glycogen-storage disease type II.	Aspartic Acid	30-33	alpha glucosidase	Homo sapiens	50-77
8439212-6	1993	Two of these 46 tumors had two different mutations to aspartic acid (GAT) and to valine (GTT) in Ki-ras codon 12.	Aspartic Acid	54-67	glycine-N-acyltransferase	Homo sapiens	69-72
8094340-10	1993	Depolarization of cultures with high potassium, veratridine, or exposure to the excitatory neurotransmitter aspartate, resulted in a two- to threefold increase in the expression of both the p75 protein and messenger RNA.	Aspartic Acid	108-117	TNF receptor superfamily member 1B	Homo sapiens	190-193
8096500-5	1993	These Bw52, B13, and B44 alleles share the unique amino acids, serine and aspartic acid at positions 67 and 77, respectively.	Aspartic Acid	74-87	BW52	Homo sapiens	6-10
8096500-5	1993	These Bw52, B13, and B44 alleles share the unique amino acids, serine and aspartic acid at positions 67 and 77, respectively.	Aspartic Acid	74-87	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	12-15
8488752-3	1993	Aminopeptidase activities were studied by measuring the rate of hydrolysis of the artificial substrates Lys-, Arg-, Asp- and Tyr-2-naphthylamides (fluorimetrically detected in triplicate).	Aspartic Acid	116-119	carboxypeptidase Q	Homo sapiens	0-14
8437103-0	1993	Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia-induced [3H]aspartate release in hippocampal slices.	Aspartic Acid	82-91	nascent polypeptide associated complex subunit alpha	Homo sapiens	18-26
8463133-4	1993	The mutation consisted of a guanine-to-adenine transition in the first base of codon 13 of c-Ki-ras which replaced wild-type glycine with serine, indicating that a putative glycine-to-aspartic acid change is not necessarily the critical event for c-Ki-ras gene activation in codon 13.	Aspartic Acid	184-197	KRAS proto-oncogene, GTPase	Homo sapiens	91-99
8463133-4	1993	The mutation consisted of a guanine-to-adenine transition in the first base of codon 13 of c-Ki-ras which replaced wild-type glycine with serine, indicating that a putative glycine-to-aspartic acid change is not necessarily the critical event for c-Ki-ras gene activation in codon 13.	Aspartic Acid	184-197	KRAS proto-oncogene, GTPase	Homo sapiens	247-255
8430097-7	1993	Consistent with the rapid turnover of the tll protein, it contains a PEST sequence (rich in proline, glutamate and aspartate, serine, and threonine) that is also conserved.	Aspartic Acid	115-124	tailless	Drosophila melanogaster	42-45
8459774-5	1993	A single amino acid change of asparagine (N) to aspartate (D) at position 54, adjacent to the site of VirG phosphorylation, aspartate 52, resulted in this constitutive phenotype.	Aspartic Acid	48-57	two-component response regulator VirG	Agrobacterium tumefaciens	102-106
8459774-5	1993	A single amino acid change of asparagine (N) to aspartate (D) at position 54, adjacent to the site of VirG phosphorylation, aspartate 52, resulted in this constitutive phenotype.	Aspartic Acid	124-133	two-component response regulator VirG	Agrobacterium tumefaciens	102-106
8420978-10	1993	Third, the Asp-10 of Nt-hsc70 was replaced by Asn.	Aspartic Acid	11-14	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	24-29
8380576-2	1993	In the present study, the single-site hEGF mutants Tyr13--&gt;His, Tyr22--&gt;Asp, Ile23--&gt;Thr, and Leu26--&gt;Gly were genetically combined with the Leu47--&gt;Ala hEGF mutant to produce a series of double-site mutant hEGF gene products having alterations simultaneously at two sites, in separate domains, within the same hEGF molecule.	Aspartic Acid	78-81	epidermal growth factor	Homo sapiens	38-42
8093615-2	1993	At variance with platelet alpha IIb beta 3 or endothelial cell alpha v beta 3 integrins, CD11b/CD18 interacts with a approximately 30-kDa plasmic fragment D (D30) of fibrinogen that lacks the Arg-Gly-Asp sequences in the A alpha chain and the carboxyl terminus of the gamma chain.	Aspartic Acid	200-203	integrin subunit alpha M	Homo sapiens	89-94
8093615-2	1993	At variance with platelet alpha IIb beta 3 or endothelial cell alpha v beta 3 integrins, CD11b/CD18 interacts with a approximately 30-kDa plasmic fragment D (D30) of fibrinogen that lacks the Arg-Gly-Asp sequences in the A alpha chain and the carboxyl terminus of the gamma chain.	Aspartic Acid	200-203	integrin subunit beta 2	Homo sapiens	95-99
8416937-0	1993	Aspartic acid 320 is required for optimal activity of rat pancreatic cholesterol esterase.	Aspartic Acid	0-13	carboxyl ester lipase	Rattus norvegicus	58-89
8416973-7	1993	The protein has the sequence His-Asp-Glu-Leu (HDEL) at its carboxyl terminus.	Aspartic Acid	33-36	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	46-50
8416937-9	1993	These results strongly suggested that aspartic acid 320 is an important component of the catalytic triad of pancreatic cholesterol esterase.	Aspartic Acid	38-51	carboxyl ester lipase	Rattus norvegicus	108-139
8373751-1	1993	A tetrapeptide RGDS (Arg-Gly-Asp-Ser), which is one of the active sites of cell adhesive proteins, was synthesized according to the solution method and covalently coupled onto monodisperse microspheres.	Aspartic Acid	29-32	ral guanine nucleotide dissociation stimulator	Homo sapiens	15-19
8364096-2	1993	The fibronectin cell binding domain -Arg-Gly-Asp-Ser- (-RGDS-) localizes at the junction of hydrophobicity and hydrophilicity.	Aspartic Acid	45-48	fibronectin 1	Homo sapiens	4-15
7678224-9	1993	Most likely, Ile 51 and Phe 54 act as MHC-anchoring residues, whereas Asp 53 represents a critical TcR contact residue for all of the clones.	Aspartic Acid	70-73	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	99-102
8318987-3	1993	The PCR product from one of five patients revealed an alteration when mixed oligonucleotides representing variants of the second letter at codon 12 of this gene were used as 5" primers, and further experiments showed a mutation of GGT (Gly) to GAT (Asp) at codon 12.	Aspartic Acid	249-252	glycine-N-acyltransferase	Homo sapiens	244-247
8454570-2	1993	One of these sequences, Arg-Gly-Asp-Ser (RGDS) tetrapeptide, was shown to be transferred to a truncated form of Staphylococcal IgG-binding protein (hereafter referred to as tSPA) with retention of its cell-adhesive activity [Maeda, T. et al.	Aspartic Acid	32-35	ral guanine nucleotide dissociation stimulator	Homo sapiens	41-45
7992552-3	1993	In the same cell model, lovastatin, an inhibitor of beta hydroxy-beta methyl-glutaryl-CoA-reductase and, hence, of farnesylation of p21ras, partially protects aspartate transport from the inhibition observed upon steroid treatment.	Aspartic Acid	159-168	Harvey rat sarcoma virus oncogene	Mus musculus	132-138
8417803-0	1993	Arg-Gly-Asp-dependent occupancy of GPIIb/IIIa by applaggin: evidence for internalization and cycling of a platelet integrin.	Aspartic Acid	8-11	integrin subunit alpha 2b	Homo sapiens	35-40
8419077-6	1993	The DQ beta chains encoded from all these alleles have the replacement of aspartic acid residue at position 57 (Asp57), as well as the DQB1*0201 allele which was found in all 30 DQw2-positive coeliac patients.	Aspartic Acid	74-87	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-11
8417376-4	1993	A strong association between absence of an aspartic acid (Asp) in position 57 of DQB1 beta chain in homozygous conditions and susceptibility to IDDM was found.	Aspartic Acid	43-56	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	81-85
7680090-5	1993	An aspartic acid located in TM3 is likely to bind to the ammonium headgroup of muscarinic ligands, and multiple hydroxyl-containing amino acids contribute to agonist but not antagonist binding.	Aspartic Acid	3-16	tropomyosin 3	Homo sapiens	28-31
8417376-4	1993	A strong association between absence of an aspartic acid (Asp) in position 57 of DQB1 beta chain in homozygous conditions and susceptibility to IDDM was found.	Aspartic Acid	58-61	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	81-85
8417376-8	1993	The non-Asp allele most frequently found in IDDM subjects was the DQB1 0201 allele and this finding was statistically significant (Pc value &lt; 0.05, relative risk = 5.01).	Aspartic Acid	8-11	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	66-70
8474224-1	1993	Monoclonal antibodies (TB1 & TB2), which were obtained by immunization of 24 amino acids in BALB/c mice, bound specifically to the amyloid senile plaque and amyloid-angiopathic lesions of brain tissues of patients with Alzheimer"s disease (AD) or with senile dementia of Alzheimer type (SDAT), and strongly reacted with the 1st part (Asp-Ala-Glu-Phe-Arg-His-Asp) of beta-protein.	Aspartic Acid	334-337	trophoblast specific protein alpha	Mus musculus	23-26
8474224-1	1993	Monoclonal antibodies (TB1 & TB2), which were obtained by immunization of 24 amino acids in BALB/c mice, bound specifically to the amyloid senile plaque and amyloid-angiopathic lesions of brain tissues of patients with Alzheimer"s disease (AD) or with senile dementia of Alzheimer type (SDAT), and strongly reacted with the 1st part (Asp-Ala-Glu-Phe-Arg-His-Asp) of beta-protein.	Aspartic Acid	358-361	trophoblast specific protein alpha	Mus musculus	23-26
8433973-1	1993	Dihydrofolate reductase mutants with amino acid replacements in the active center (Thr35--&gt;Asp mutant, Arg57--&gt;His mutant and the mutant with triple replacement Thr35--&gt;Asp, Asn37--&gt;Ser, Arg57--&gt;His) were obtained by site-directed mutagenesis.	Aspartic Acid	94-97	dihydrofolate reductase	Homo sapiens	0-23
21043846-5	1993	Like some other adhesive proteins such as fibrinogen, fibronectin, and von Willebrand factor, vitronectin contains the amino-acid sequence Arg-Gly-Asp (RGD) which enables binding to the platelet membrane glycoprotein complex IIb/IIIa (GPIIb/IIIa).	Aspartic Acid	147-150	vitronectin	Homo sapiens	94-105
21043846-5	1993	Like some other adhesive proteins such as fibrinogen, fibronectin, and von Willebrand factor, vitronectin contains the amino-acid sequence Arg-Gly-Asp (RGD) which enables binding to the platelet membrane glycoprotein complex IIb/IIIa (GPIIb/IIIa).	Aspartic Acid	147-150	integrin subunit alpha 2b	Homo sapiens	235-240
1479591-0	1992	Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen.	Aspartic Acid	65-68	fibrinogen beta chain	Homo sapiens	85-95
1334492-8	1992	We conclude that 1) the Asp residues play a specific role in the Ca(2+)-dependent inhibition of protein C activation by thrombin; 2) these mutations alter the affinity of Ca2+ for the high affinity binding site; and 3) the Asp residues in the P3 and P3" sites do not contribute in a positive fashion to rapid activation by the thrombin-thrombomodulin complex.	Aspartic Acid	24-27	coagulation factor II, thrombin	Homo sapiens	120-128
1334492-8	1992	We conclude that 1) the Asp residues play a specific role in the Ca(2+)-dependent inhibition of protein C activation by thrombin; 2) these mutations alter the affinity of Ca2+ for the high affinity binding site; and 3) the Asp residues in the P3 and P3" sites do not contribute in a positive fashion to rapid activation by the thrombin-thrombomodulin complex.	Aspartic Acid	24-27	coagulation factor II, thrombin	Homo sapiens	327-335
1334492-8	1992	We conclude that 1) the Asp residues play a specific role in the Ca(2+)-dependent inhibition of protein C activation by thrombin; 2) these mutations alter the affinity of Ca2+ for the high affinity binding site; and 3) the Asp residues in the P3 and P3" sites do not contribute in a positive fashion to rapid activation by the thrombin-thrombomodulin complex.	Aspartic Acid	24-27	thrombomodulin	Homo sapiens	336-350
1334492-8	1992	We conclude that 1) the Asp residues play a specific role in the Ca(2+)-dependent inhibition of protein C activation by thrombin; 2) these mutations alter the affinity of Ca2+ for the high affinity binding site; and 3) the Asp residues in the P3 and P3" sites do not contribute in a positive fashion to rapid activation by the thrombin-thrombomodulin complex.	Aspartic Acid	223-226	coagulation factor II, thrombin	Homo sapiens	120-128
8081722-4	1993	In the first model, the beta-adrenergic receptor is used as a reference with the catechol moieties of dopamine interacting with two Ser residues in TM5, and the Asp residue in TM3 interacting with the protonated nitrogen of dopamine.	Aspartic Acid	161-164	tropomyosin 3	Homo sapiens	176-179
1464619-3	1992	Much more dramatic increases in the C50 for Ca2+ were observed for [Gla16--&gt;Asp]r-PC (&gt; 75-fold) and [Gla26--&gt;Asp]r-PC (ca.	Aspartic Acid	79-82	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	85-87
1464619-5	1992	A substantially larger maximum fluorescence change (&gt; 3-fold) as compared to that for wtr-PC, was also found in the case of the Ca2+/[Gla16--&gt;Asp]r-PC complex, suggesting that the final Ca(2+)-induced conformation for this variant is dissimilar to that for wtr-PC and the above mutants.	Aspartic Acid	148-151	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	93-95
1464619-5	1992	A substantially larger maximum fluorescence change (&gt; 3-fold) as compared to that for wtr-PC, was also found in the case of the Ca2+/[Gla16--&gt;Asp]r-PC complex, suggesting that the final Ca(2+)-induced conformation for this variant is dissimilar to that for wtr-PC and the above mutants.	Aspartic Acid	148-151	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	154-156
1464619-5	1992	A substantially larger maximum fluorescence change (&gt; 3-fold) as compared to that for wtr-PC, was also found in the case of the Ca2+/[Gla16--&gt;Asp]r-PC complex, suggesting that the final Ca(2+)-induced conformation for this variant is dissimilar to that for wtr-PC and the above mutants.	Aspartic Acid	148-151	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	154-156
1464619-8	1992	A similar C50 value was found for [Gla25--&gt;Asp]r-PC.	Aspartic Acid	46-49	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	52-54
1483477-4	1992	In addition, the Arg156-Phe157 thrombin-cleavage site in the u-PA moiety of K12G0S32 is removed by substitution of Phe157 with Asp.	Aspartic Acid	127-130	plasminogen activator, urokinase	Homo sapiens	61-65
1465386-5	1992	By mutating each individual residue within this sequence to alanine, three residues (Tyr-440, Asp-441, and His-444) were identified as being critical for IFN-gamma-dependent (i) upregulation of major histocompatibility complex class I proteins, (ii) activation of the IFN regulatory factor 1 gene, and (iii) stimulation of cells to produce nitric oxide.	Aspartic Acid	94-97	interferon gamma	Homo sapiens	154-163
1334085-5	1992	The purified ASP is 78 kDa as estimated by SDS-polyacrylamide gel electrophoresis and binds to its specific recognition site, -126/-113-bp CACTCTGTGGGCGG, which has been demonstrated to be the minimum cAMP regulatory sequence of the human CYP21B gene.	Aspartic Acid	13-16	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	239-245
1483477-4	1992	In addition, the Arg156-Phe157 thrombin-cleavage site in the u-PA moiety of K12G0S32 is removed by substitution of Phe157 with Asp.	Aspartic Acid	127-130	coagulation factor II, thrombin	Homo sapiens	31-39
1458688-2	1992	This substitution causes a replacement of glycine (codon GGC) with aspartic acid (codon GAC).	Aspartic Acid	67-80	gamma-glutamylcyclotransferase	Homo sapiens	57-60
1466664-4	1992	The D-aspartate content of elastin, purified from infrarenal aorta; increased linearly with age from 3% of the total aspartate in youth to 13% in the mid 80s.	Aspartic Acid	6-15	elastin	Homo sapiens	27-34
1466664-6	1992	The apparent first order rate constant for the racemization of L-aspartate in elastin was 1.14 x 10(-3).	Aspartic Acid	63-74	elastin	Homo sapiens	78-85
1466664-7	1992	The D-aspartate content of the elastin bound glycoproteins increased by only a small amount, from 3% in the mid 30s to 6% in the mid 80s.	Aspartic Acid	6-15	elastin	Homo sapiens	31-38
1332958-5	1992	Asp to Ala mutations in extracellular loop 1, TM-4, and TM-5 did not decrease binding affinity, but an Asp to Ala mutation in TM-2 caused the affinity to decrease 8-fold.	Aspartic Acid	103-106	tropomyosin 1, alpha	Mus musculus	126-130
1451011-5	1992	These acidic proteins can affect the surface properties of collagen fibril, and BSP, having the cell-attachment sequence Arg-Gly-Asp, possibly mediates interaction between collagen fibril and cells.	Aspartic Acid	129-132	integrin binding sialoprotein	Homo sapiens	80-83
1493949-3	1992	This was based on the recent finding that the sequence of the binding domain of the platelet membrane receptor to fibrinogen was identified as TDVNGDGRHDL (one-letter amino acid code; Thr-Asp-Val-Asn-Gly-Asp-Gly-Arg-His-Asp-Leu), entitled B12.	Aspartic Acid	188-191	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	239-242
1477092-3	1992	An amino acid substitution in the exon 1 at codon 54 in the MBP gene (GGC [glycine] to GAC [aspartic acid]) has been shown to be closely associated with low MBP concentration in Caucasoids.	Aspartic Acid	92-105	myelin basic protein	Homo sapiens	60-63
1477092-3	1992	An amino acid substitution in the exon 1 at codon 54 in the MBP gene (GGC [glycine] to GAC [aspartic acid]) has been shown to be closely associated with low MBP concentration in Caucasoids.	Aspartic Acid	92-105	gamma-glutamylcyclotransferase	Homo sapiens	70-73
1477092-3	1992	An amino acid substitution in the exon 1 at codon 54 in the MBP gene (GGC [glycine] to GAC [aspartic acid]) has been shown to be closely associated with low MBP concentration in Caucasoids.	Aspartic Acid	92-105	myelin basic protein	Homo sapiens	157-160
1452354-1	1992	Compositional analysis of streptococcal C5a peptidase (SCPA) cleavage products from a synthetic peptide corresponding to the 20 C-terminal residues of C5a demonstrated that the target cleavage site is His-Lys rather than Lys-Asp, as previously suggested.	Aspartic Acid	225-228	complement C5a receptor 1	Homo sapiens	40-43
1452354-1	1992	Compositional analysis of streptococcal C5a peptidase (SCPA) cleavage products from a synthetic peptide corresponding to the 20 C-terminal residues of C5a demonstrated that the target cleavage site is His-Lys rather than Lys-Asp, as previously suggested.	Aspartic Acid	225-228	complement C5a receptor 1	Homo sapiens	151-154
1493949-3	1992	This was based on the recent finding that the sequence of the binding domain of the platelet membrane receptor to fibrinogen was identified as TDVNGDGRHDL (one-letter amino acid code; Thr-Asp-Val-Asn-Gly-Asp-Gly-Arg-His-Asp-Leu), entitled B12.	Aspartic Acid	204-207	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	239-242
1493949-3	1992	This was based on the recent finding that the sequence of the binding domain of the platelet membrane receptor to fibrinogen was identified as TDVNGDGRHDL (one-letter amino acid code; Thr-Asp-Val-Asn-Gly-Asp-Gly-Arg-His-Asp-Leu), entitled B12.	Aspartic Acid	204-207	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	239-242
1331527-4	1992	One of the cell lines expressed a mutant of hPVR, in which both asparagine residues of the two N-glycosylation sites of the V domain were changed to aspartate (N105D) and serine (N120S), respectively.	Aspartic Acid	149-158	PVR cell adhesion molecule	Homo sapiens	44-48
1295891-2	1992	AspAT of strain FTF-INRA was similar in the amino donor specificity to the enzyme of M. thermoformicicum strain SF-4, in that it was active on L-cysteine and L-cysteine sulfinate in addition to L-glutamate and L-aspartate.	Aspartic Acid	210-221	nuclear receptor subfamily 5 group A member 2	Homo sapiens	16-19
1469085-6	1992	A synthetic peptide of the Arg-Gly-Asp (RGD) domain in entactin, SIGFRGDGQTC (S-RGD), mediated PMN adhesion and chemotaxis, and preexposure of PMN to S-RGD blocked PMN adhesion and chemotaxis induced by entactin without diminishing the adhesive and chemotactic activities of fMLP.	Aspartic Acid	35-38	nidogen 1	Homo sapiens	55-63
1469085-6	1992	A synthetic peptide of the Arg-Gly-Asp (RGD) domain in entactin, SIGFRGDGQTC (S-RGD), mediated PMN adhesion and chemotaxis, and preexposure of PMN to S-RGD blocked PMN adhesion and chemotaxis induced by entactin without diminishing the adhesive and chemotactic activities of fMLP.	Aspartic Acid	35-38	nidogen 1	Homo sapiens	203-211
1469085-6	1992	A synthetic peptide of the Arg-Gly-Asp (RGD) domain in entactin, SIGFRGDGQTC (S-RGD), mediated PMN adhesion and chemotaxis, and preexposure of PMN to S-RGD blocked PMN adhesion and chemotaxis induced by entactin without diminishing the adhesive and chemotactic activities of fMLP.	Aspartic Acid	35-38	formyl peptide receptor 1	Homo sapiens	275-279
1284246-1	1992	A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.	Aspartic Acid	248-263	aminoacylase 1	Homo sapiens	52-66
1284246-1	1992	A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.	Aspartic Acid	248-263	aminoacylase 1	Homo sapiens	101-106
1359905-0	1992	Identification of aspartic acid 514 through glutamic acid 542 as a glycoprotein Ib-IX complex receptor recognition sequence in von Willebrand factor.	Aspartic Acid	18-31	von Willebrand factor	Bos taurus	127-148
1332763-0	1992	Effect of Asp-235--&gt;Asn substitution on the absorption spectrum and hydrogen peroxide reactivity of cytochrome c peroxidase.	Aspartic Acid	10-13	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	103-126
1332764-3	1992	Measurement of transferred NOEs and molecular modeling indicate that the side chain of the Asp(P3) residue may form a hydrogen bond with thrombin and, by doing so, it is brought near a positively-charged thrombin residue Arg(221A), thereby partially neutralizing the negative charge of an Asp residue at this site of protein substrates.	Aspartic Acid	91-94	coagulation factor II, thrombin	Bos taurus	137-145
1332764-3	1992	Measurement of transferred NOEs and molecular modeling indicate that the side chain of the Asp(P3) residue may form a hydrogen bond with thrombin and, by doing so, it is brought near a positively-charged thrombin residue Arg(221A), thereby partially neutralizing the negative charge of an Asp residue at this site of protein substrates.	Aspartic Acid	91-94	coagulation factor II, thrombin	Bos taurus	204-212
1332764-3	1992	Measurement of transferred NOEs and molecular modeling indicate that the side chain of the Asp(P3) residue may form a hydrogen bond with thrombin and, by doing so, it is brought near a positively-charged thrombin residue Arg(221A), thereby partially neutralizing the negative charge of an Asp residue at this site of protein substrates.	Aspartic Acid	289-292	coagulation factor II, thrombin	Bos taurus	204-212
1431103-2	1992	Murine IL-1 beta is initially synthesized as an inactive 33-kDa pro-molecule that is activated by proteolytic cleavage between Asp-117 and Val-118 to generate the 17-kDa mature IL-1 beta protein.	Aspartic Acid	127-130	interleukin 1 beta	Mus musculus	7-16
1385408-5	1992	In the disintegrin region, the Arg-Gly-Asp sequence is replaced by Glu-Cys-Asp, as found in non-Arg-Gly-Asp disintegrin regions of HR1B and a guinea pig sperm fusion protein PH-30 beta.	Aspartic Acid	39-42	disintegrin and metalloproteinase domain-containing protein 2	Cavia porcellus	174-184
1385408-5	1992	In the disintegrin region, the Arg-Gly-Asp sequence is replaced by Glu-Cys-Asp, as found in non-Arg-Gly-Asp disintegrin regions of HR1B and a guinea pig sperm fusion protein PH-30 beta.	Aspartic Acid	75-78	disintegrin and metalloproteinase domain-containing protein 2	Cavia porcellus	174-184
1385408-5	1992	In the disintegrin region, the Arg-Gly-Asp sequence is replaced by Glu-Cys-Asp, as found in non-Arg-Gly-Asp disintegrin regions of HR1B and a guinea pig sperm fusion protein PH-30 beta.	Aspartic Acid	75-78	disintegrin and metalloproteinase domain-containing protein 2	Cavia porcellus	174-184
1279699-7	1992	GLAST is specific for L-glutamate and L-aspartate, shows strict dependence on Na+ ions, and is inhibited by DL-threo-3-hydroxy-aspartate.	Aspartic Acid	38-49	solute carrier family 1 member 3	Rattus norvegicus	0-5
1426261-0	1992	The role of conserved aspartate and serine residues in ligand binding and in function of the 5-HT1A receptor: a site-directed mutation study.	Aspartic Acid	22-31	5-hydroxytryptamine receptor 1A	Homo sapiens	93-108
1438261-6	1992	In IgA-D individuals not carrying the three overrepresented DR-DQ haplotypes, the same positive association with a non-aspartic acid residue at position 57 of the HLA-DQ beta chain was seen.	Aspartic Acid	119-132	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	163-166
1443599-1	1992	The angiotensin I-based peptide Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Glu-Glu-Ser yields angiotensin I (Ang I) and Leu-Glu-Glu-Ser upon hydrolysis by the human immunodeficiency virus type 1 (HIV-1) protease, but not by human renin.	Aspartic Acid	32-35	renin	Homo sapiens	231-236
1330679-2	1992	Here we show that Su-var(3)6 and an allelic mutant, e078, which both show suppression of PEV in the heterozygous state, have point mutations (Gly220--&gt;Ser and Gly220--&gt;Asp, respectively) in a protein phosphatase 1 catalytic subunit located at 87B (PP1 87B).	Aspartic Acid	174-177	Protein phosphatase 1 at 87B	Drosophila melanogaster	18-28
1429612-1	1992	Chemical, genetic, and structural studies have defined a critical role for Asp-49 in the calcium-mediated activation of extracellular phospholipases A2 (PLA2).	Aspartic Acid	75-78	phospholipase A2 group IIA	Homo sapiens	153-157
1429612-2	1992	In 1984, a new class of PLA2 was isolated in which this invariant aspartate was replaced with a lysine (Maragnore, J.M., Merutka, G., Cho, W., Welches, W., Kezdy, F.J., and Heinrikson, R.L.	Aspartic Acid	66-75	phospholipase A2 group IIA	Homo sapiens	24-28
1444916-2	1992	Two members of another family with autosomal dominant retinitis pigmentosa showed a guanine-to-thymine mutation in the first nucleotide of codon 190 in the rhodopsin gene that resulted in an aspartate-to-tyrosine change.	Aspartic Acid	191-200	rhodopsin	Homo sapiens	156-165
1329948-9	1992	These results suggest that the Schiff base nitrogen in rhodopsin is located between residues 113 and 117 but there is enough flexibility in the protein to allow partial interaction with an Asp at position 120.	Aspartic Acid	189-192	rhodopsin	Bos taurus	55-64
1327757-4	1992	PHO4 binding specificity is altered by mutation at any of three different positions in the basic region, including a single Glu to Asp substitution.	Aspartic Acid	131-134	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	0-4
1358911-9	1992	Since DQB1*0303 is identical to DQB1*0302 except that it contains Asp 57, the data suggests that an Asp 57-positive allele confers susceptibility to IDDM when the whole molecule of the DQ beta chain is similar to other susceptible DQ beta chains.	Aspartic Acid	66-69	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	6-10
1358911-9	1992	Since DQB1*0303 is identical to DQB1*0302 except that it contains Asp 57, the data suggests that an Asp 57-positive allele confers susceptibility to IDDM when the whole molecule of the DQ beta chain is similar to other susceptible DQ beta chains.	Aspartic Acid	100-103	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	6-10
1358911-9	1992	Since DQB1*0303 is identical to DQB1*0302 except that it contains Asp 57, the data suggests that an Asp 57-positive allele confers susceptibility to IDDM when the whole molecule of the DQ beta chain is similar to other susceptible DQ beta chains.	Aspartic Acid	100-103	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	32-36
1458828-8	1992	Two proteolytic peptides, D7 and D9 derived from canine protein 4.1, both corresponding to the human sequence Thr492-...-Asn (or Asp)502-...-Lys505 showed the same sequence, Thr-Gln-Thr-...-Lys, except that the 11th residue equivalent to the 502nd amino acid was Asn in D7 while it was Asp in D9, indicating that deamidation occurs at the same position in canine protein 4.1 as in humans.	Aspartic Acid	129-132	erythrocyte membrane protein band 4.1	Canis lupus familiaris	56-67
1458828-8	1992	Two proteolytic peptides, D7 and D9 derived from canine protein 4.1, both corresponding to the human sequence Thr492-...-Asn (or Asp)502-...-Lys505 showed the same sequence, Thr-Gln-Thr-...-Lys, except that the 11th residue equivalent to the 502nd amino acid was Asn in D7 while it was Asp in D9, indicating that deamidation occurs at the same position in canine protein 4.1 as in humans.	Aspartic Acid	286-289	erythrocyte membrane protein band 4.1	Canis lupus familiaris	56-67
1484502-2	1992	DSP is rich in aspartic acid, glutamic acid, glycine and serine, but contains no cysteine or phosphate.	Aspartic Acid	15-28	dentin sialophosphoprotein	Homo sapiens	0-3
1400461-3	1992	Based on the close sequence homology with pancreatic lipase, both LPL and HL are believed to have a two-domain structure composed of an amino-terminal (NH2-terminal) domain containing the catalytic Ser-His-Asp triad and a smaller carboxyl-terminal (COOH-terminal) domain.	Aspartic Acid	206-209	lipoprotein lipase	Homo sapiens	66-69
1397329-3	1992	Recent determination of the three-dimensional structures of pancreatic and microbial lipases has shown that the order of their catalytic residues is Ser, Asp, His, and this fits the order Ser, His of prolyl oligopeptidase.	Aspartic Acid	154-157	prolyl endopeptidase	Homo sapiens	200-221
1397329-5	1992	This comparison identifies the catalytic Asp residue in the prolyl oligopeptidase family.	Aspartic Acid	41-44	prolyl endopeptidase	Homo sapiens	60-81
1400325-4	1992	Cytoskeletal association and platelet aggregation were inhibited by the peptide Arg-Gly-Asp-Ser (RGDS) (but not by Arg-Gly-Glu-Ser (RGES)), by 10E5 antibody against glycoprotein (Gp) IIb/IIIa, and by EGTA.	Aspartic Acid	88-91	ral guanine nucleotide dissociation stimulator	Homo sapiens	97-101
1433291-1	1992	A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.	Aspartic Acid	18-21	insulin	Homo sapiens	39-46
1433291-2	1992	The solution structure of the B9(Asp) mutant of human insulin has been determined by two-dimensional 1H nuclear magnetic resonance spectroscopy.	Aspartic Acid	33-36	insulin	Homo sapiens	54-61
1433291-12	1992	Thus, the monomer in the solution dimer shows a conformation similar to that of the crystal monomer in molecular regions close to the monomer-monomer interface, whereas it assumes a conformation similar to that of the solution structure of monomeric insulin in other regions, suggesting that B9(Asp) insulin adopts a monomer-like conformation when this is not inconsistent with the monomer-monomer arrangement in the dimer.	Aspartic Acid	295-298	insulin	Homo sapiens	250-257
1401911-1	1992	Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands.	Aspartic Acid	166-169	CD47 molecule	Homo sapiens	0-27
1401911-1	1992	Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands.	Aspartic Acid	166-169	CD47 molecule	Homo sapiens	29-32
1400496-0	1992	Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity.	Aspartic Acid	61-70	farnesyl diphosphate synthase	Rattus norvegicus	96-125
1400496-1	1992	Comparison of the farnesyl diphosphate (FPP) synthase amino acid sequences from four species with amino acid sequences from the related enzymes hexaprenyl diphosphate synthase and geranylgeranyl diphosphate synthase show the presence of two aspartate rich highly conserved domains.	Aspartic Acid	241-250	farnesyl diphosphate synthase	Rattus norvegicus	18-53
1400496-3	1992	In order to investigate the role of this second aspartate-rich domain in rat FPP synthase, we mutated the first or third aspartate to glutamate, expressed the wild-type and mutant enzymes in Escherichia coli, and purified them to apparent homogeneity using a single chromatographic step.	Aspartic Acid	48-57	farnesyl diphosphate synthase	Rattus norvegicus	77-89
1400496-9	1992	These results suggest that the first aspartate in the second domain is involved in the catalysis by FPP synthase.	Aspartic Acid	37-46	farnesyl diphosphate synthase	Rattus norvegicus	100-112
1402647-8	1992	In addition, the negatively charged amino acids Asp and Glu were mostly excluded from the DR1 binding sequences, and the small amino acid residues Gly and Ala were enriched at position 6.	Aspartic Acid	48-51	down-regulator of transcription 1	Homo sapiens	90-93
1417782-6	1992	The second intron interrupts the canonical Asp-Arg-Tyr sequence, which is located at the end of the third transmembrane domain of the heptahelical receptors, as with the substance P, substance K, dopamine D2 and dopamine D3 receptor genes.	Aspartic Acid	43-46	tachykinin precursor 1	Bos taurus	170-181
1417782-6	1992	The second intron interrupts the canonical Asp-Arg-Tyr sequence, which is located at the end of the third transmembrane domain of the heptahelical receptors, as with the substance P, substance K, dopamine D2 and dopamine D3 receptor genes.	Aspartic Acid	43-46	tachykinin precursor 1	Bos taurus	183-194
1397082-4	1992	Attachment was inhibited by exposure of the fibronectin-coated surfaces to antibodies against the cell binding domain of fibronectin or by incubating the cells with peptides containing the recognition sequence Arg-Gly-Asp (RGD) known from vertebrate cells.	Aspartic Acid	218-221	fibronectin 1	Homo sapiens	44-55
1400872-3	1992	Sequence analysis of these exons revealed a point mutation encoding an amino acid substitution (Asp --&gt; Asn) at residue 327 in the SHBG polypeptide, and the same mutation was identified in three siblings who also appear to be homozygous for this trait.	Aspartic Acid	96-99	sex hormone-binding globulin	Cricetulus griseus	134-138
1439759-6	1992	Binding activity was found to occur within a 26-amino acid sequence of Ig-alpha and Ig-beta that contains a motif [(Asp or Glu)-(any amino acid)7-(Asp or Glu)-Tyr-(any amino acid)3-Leu-(any amino acid)7-Tyr-(any amino acid)2-(Leu or Ile)] previously implicated in signal transduction via other receptors including the Fc epsilon receptor I and the T cell antigen receptor.	Aspartic Acid	116-119	CD79a molecule	Homo sapiens	71-79
1439759-6	1992	Binding activity was found to occur within a 26-amino acid sequence of Ig-alpha and Ig-beta that contains a motif [(Asp or Glu)-(any amino acid)7-(Asp or Glu)-Tyr-(any amino acid)3-Leu-(any amino acid)7-Tyr-(any amino acid)2-(Leu or Ile)] previously implicated in signal transduction via other receptors including the Fc epsilon receptor I and the T cell antigen receptor.	Aspartic Acid	116-119	CD79b molecule	Homo sapiens	84-91
1439759-6	1992	Binding activity was found to occur within a 26-amino acid sequence of Ig-alpha and Ig-beta that contains a motif [(Asp or Glu)-(any amino acid)7-(Asp or Glu)-Tyr-(any amino acid)3-Leu-(any amino acid)7-Tyr-(any amino acid)2-(Leu or Ile)] previously implicated in signal transduction via other receptors including the Fc epsilon receptor I and the T cell antigen receptor.	Aspartic Acid	147-150	CD79a molecule	Homo sapiens	71-79
1439759-6	1992	Binding activity was found to occur within a 26-amino acid sequence of Ig-alpha and Ig-beta that contains a motif [(Asp or Glu)-(any amino acid)7-(Asp or Glu)-Tyr-(any amino acid)3-Leu-(any amino acid)7-Tyr-(any amino acid)2-(Leu or Ile)] previously implicated in signal transduction via other receptors including the Fc epsilon receptor I and the T cell antigen receptor.	Aspartic Acid	147-150	CD79b molecule	Homo sapiens	84-91
1358663-8	1992	40, 8) suggests that dopamine interacts with aspartate 114 of TM3 and the serines of TM5 (194 and 197) with the transmembranes arranged in a counterclockwise manner when viewed from the extracellular space.	Aspartic Acid	45-54	tropomyosin 3	Homo sapiens	62-65
1358663-10	1992	In addition, two methionines (116 and 117) were mutated to evaluate whether residues near aspartate (114) of the dopamine D2 receptor are critical in differentiating dopamine receptor agonists from adrenoceptor agonists.	Aspartic Acid	90-99	dopamine receptor D2	Homo sapiens	113-133
1429881-2	1992	In the case of endothelin receptors, however, a lysine residue replaces this conserved aspartic acid residue.	Aspartic Acid	87-100	endothelin 1	Rattus norvegicus	15-25
1429881-3	1992	To access the importance of this residue in ligand binding, we have replaced it with an aspartic acid in the rat endothelin type B (ETb) receptor by PCR mediated mutagenesis.	Aspartic Acid	88-101	endothelin receptor type B	Rattus norvegicus	132-135
1486236-3	1992	Certain metabolite sequences including Gly, Asp, Arg, and Ser (GAAS) proved to be critical for cell interactions, e.g. with fibronectin.	Aspartic Acid	44-47	fibronectin 1	Mus musculus	124-135
1338910-7	1992	We conclude that substitution of the uncharged Asn or Tyr for the acidic Asp at residue 187 creates a conformation that may be preferentially amyloidogenic for GSN.	Aspartic Acid	73-76	gelsolin	Homo sapiens	160-163
1475017-6	1992	Enzyme inhibitor analysis indicated that PRL proteolysis could be blocked by aspartate and serine protease inhibitors, but not sulfhydryl, metalloenzyme or trypsin protease inhibitors.	Aspartic Acid	77-86	prolactin	Rattus norvegicus	41-44
1388157-5	1992	In contrast, the nucleophiles in the active sites of sucrase-isomaltase are aspartates (Asp505 and Asp1394).	Aspartic Acid	76-86	sucrase-isomaltase, intestinal	Oryctolagus cuniculus	53-71
1388157-7	1992	Alignment of these 2 nucleophilic Glu residues in lactase-phlorizin hydrolase and of their flanking regions with published sequences of several other beta-glycosidases allows the classification of the configuration retaining glycosidases into two major families: the "Asp" and the "Glu" glycosidases, depending on the carboxylate presumed to interact with the putative oxocarbonium ion in the transition state.	Aspartic Acid	268-271	lactase-phlorizin hydrolase	Oryctolagus cuniculus	50-77
1358789-6	1992	Three children had inherited a G-to-A transition at codon 415 in exon 12 of the PAH gene, resulting in the substitution of asparagine for aspartate, whereas one child possessed an A-to-G transition at codon 306 in exon 9, causing the replacement of an isoleucine by a valine in the enzyme.	Aspartic Acid	138-147	phenylalanine hydroxylase	Homo sapiens	80-83
1379790-4	1992	Unlike human apo C-I, mature rat apo C-I contains histidine, lacks valine, and has alanine at the C terminus and aspartate as the N terminus.	Aspartic Acid	113-122	apolipoprotein C1	Rattus norvegicus	33-40
1388724-6	1992	DNA sequence analysis of beta ig-h3 indicated that it encoded a novel protein, beta IG-H3, of 683 amino acids, which contained an amino-terminal secretory sequence and a carboxy-terminal Arg-Gly-Asp (RGD) sequence that can serve as a ligand recognition site for several integrins.	Aspartic Acid	195-198	transforming growth factor beta induced	Homo sapiens	25-35
1388724-6	1992	DNA sequence analysis of beta ig-h3 indicated that it encoded a novel protein, beta IG-H3, of 683 amino acids, which contained an amino-terminal secretory sequence and a carboxy-terminal Arg-Gly-Asp (RGD) sequence that can serve as a ligand recognition site for several integrins.	Aspartic Acid	195-198	transforming growth factor beta induced	Homo sapiens	79-89
1387082-3	1992	An antagonist of human IL-4 was discovered during the studies presented here after Tyr124 of the recombinant protein had been substituted by an aspartic acid residue.	Aspartic Acid	144-157	interleukin 4	Homo sapiens	23-27
1527019-4	1992	The receptor, which consisted of two polypeptides of relative molecular masses of 150 and 116 kDa, bound to the entactin-Sepharose matrix in the presence of CaCl2, MgCl2, and MnCl2, and was eluted with EDTA, but not with Arg-Gly-Asp-containing peptides.	Aspartic Acid	229-232	nidogen 1	Homo sapiens	112-120
1517241-2	1992	Following an ill-defined activation event, the Arg-Gly-Asp (RGD) recognition site of the platelet integrin, glycoprotein IIb-IIIa (alpha IIb beta 3), can bind to fluid-phase, RGD-containing protein ligands, such as fibrinogen, or to the murine monoclonal IgM, PAC-1, which contains the sequence Arg-Tyr-Asp (RYD) within the third complementarity-determining region of its heavy chain (H3).	Aspartic Acid	55-58	dual specificity phosphatase 2	Homo sapiens	260-265
1326944-4	1992	Tetrapeptide RGDS (Arg-Gly-Asp-Ser), which blocks the interaction of ligands such as fibrinogen with platelet integrin alpha IIb beta 3 (GPIIb-IIIa), inhibited only the late-phase PtdIns(3,4)P2 accumulation that was associated with added Ca2+.	Aspartic Acid	27-30	ral guanine nucleotide dissociation stimulator	Homo sapiens	13-17
1326944-4	1992	Tetrapeptide RGDS (Arg-Gly-Asp-Ser), which blocks the interaction of ligands such as fibrinogen with platelet integrin alpha IIb beta 3 (GPIIb-IIIa), inhibited only the late-phase PtdIns(3,4)P2 accumulation that was associated with added Ca2+.	Aspartic Acid	27-30	integrin subunit alpha 2b	Homo sapiens	137-142
1386557-5	1992	Mapping of FN regions responsible for the proliferative signal was performed by stimulating melanoma cells with different FN proteolytic fragments and indicated that a significant mitogenic signal was provided by the M(r) 120,000 alpha-chymotrypsin fragment containing the Arg-Gly-Asp sequence.	Aspartic Acid	281-284	fibronectin 1	Homo sapiens	11-13
1512197-2	1992	ArcB belongs to a subclass of sensors that have not only a conserved histidine-containing transmitter domain but also a conserved aspartate-containing receiver domain of the regulator family.	Aspartic Acid	130-139	hypothetical protein	Escherichia coli	0-4
1379588-4	1992	We have identified, however, three FKBP12 surface residues (Asp-37, Arg-42, and His-87) proximal to a solvent-exposed segment of bound FK506 that may be direct contacts in the calcineurin complex.	Aspartic Acid	60-63	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	35-41
1512245-11	1992	A Ser-His-Asp catalytic triad similar to that present in serine proteases is present in human pancreatic lipase.	Aspartic Acid	10-13	pancreatic lipase	Homo sapiens	94-111
1386557-6	1992	The proliferation of melanoma cells to FN and to FN fragments was also significantly inhibited by peptides containing the Arg-Gly-Asp sequence.	Aspartic Acid	130-133	fibronectin 1	Homo sapiens	39-41
1639779-8	1992	Examination of the rat DHPR sequence shows a typical dinucleotide binding fold with Asp-37 located precisely in the position predicted for the acidic residue that participates in hydrogen bond formation with the 2"-hydroxyl moiety of all known NAD-dependent dehydrogenases.	Aspartic Acid	84-87	quinoid dihydropteridine reductase	Rattus norvegicus	23-27
1386557-6	1992	The proliferation of melanoma cells to FN and to FN fragments was also significantly inhibited by peptides containing the Arg-Gly-Asp sequence.	Aspartic Acid	130-133	fibronectin 1	Homo sapiens	49-51
1502198-6	1992	These results demonstrate that aspartate and serine residues lying within the first and seventh hydrophobic putative transmembrane regions are crucial for DAT function and provide identification of residues differentially important for cocaine binding and for dopamine uptake.	Aspartic Acid	31-40	solute carrier family 6 member 3	Homo sapiens	155-158
1385854-2	1992	A dominant suppressor of a branchpoint mutation in Saccharomyces cerevisiae, the prp16-1 allele, contains a Tyr to Asp change in the nucleotide-binding site consensus sequence.	Aspartic Acid	115-118	DEAH-box RNA helicase PRP16	Saccharomyces cerevisiae S288C	81-86
1379413-1	1992	The glycine-to-aspartic acid missense mutation at codon 551 (G551D), which is within the first nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator (CFTR), is the third most common cystic fibrosis (CF) mutation, with a worldwide frequency of 3.1% among CF chromosomes.	Aspartic Acid	15-28	CF transmembrane conductance regulator	Homo sapiens	126-177
1379413-1	1992	The glycine-to-aspartic acid missense mutation at codon 551 (G551D), which is within the first nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator (CFTR), is the third most common cystic fibrosis (CF) mutation, with a worldwide frequency of 3.1% among CF chromosomes.	Aspartic Acid	15-28	CF transmembrane conductance regulator	Homo sapiens	179-183
1463791-1	1992	A method to quantify asparagine (Asn), aspartate (Asp) and isoaspartate (isoAsp) residues in small peptides by fast atom bombardment mass spectrometry (FAB-MS) was developed.	Aspartic Acid	50-53	FA complementation group B	Homo sapiens	152-155
1386484-6	1992	When the three arginines were substituted with aspartic acids, the mutant nsP2 was localized in the cytoplasm.	Aspartic Acid	47-61	reticulon 2	Homo sapiens	74-78
1355295-1	1992	It has previously been shown that subchronic and acute administration of L-asparaginase and glutaminase inhibitors D-Aspartic acid (D-ASP) and prolyl-leucyl-glycinamide (PLG) intensifies and attenuates morphine (M) physical dependence, respectively, by the inhibition of ASP and glutamic acid (GLU) production, and subsequently their normal releases.	Aspartic Acid	134-137	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	73-87
1321599-5	1992	All amino acids known to be important for catalysis are conserved, except one glutamate which is substituted by an aspartate in PPA2.	Aspartic Acid	115-124	inorganic diphosphatase PPA2	Saccharomyces cerevisiae S288C	128-132
1497653-5	1992	The enzyme responsible for the breakdown was determined to be the lysosomal cathepsin D based on the pH optimum and the presence of aspartate in the active site of the enzyme.	Aspartic Acid	132-141	cathepsin D	Homo sapiens	76-87
1643115-7	1992	(3) Arg-Gly-Asp-Ser (RGDS) peptide, a synthetic anti-adhesive peptide, inhibited aggregation of thrombin-activated platelets in a dose-dependent manner (100-200 microM).	Aspartic Acid	12-15	ral guanine nucleotide dissociation stimulator	Homo sapiens	21-25
1643115-7	1992	(3) Arg-Gly-Asp-Ser (RGDS) peptide, a synthetic anti-adhesive peptide, inhibited aggregation of thrombin-activated platelets in a dose-dependent manner (100-200 microM).	Aspartic Acid	12-15	coagulation factor II, thrombin	Homo sapiens	96-104
1386253-9	1992	Collapse of beta-strand 1 into a hydrated space between strands 1, 2, and 4 could structurally alter a cleft in IL-1 beta that contains a cluster of highly conserved amino acids, including a key aspartic acid residue [Ju et al.	Aspartic Acid	195-208	interleukin 1 beta	Homo sapiens	112-121
1598909-11	1992	The mutation changed the GGC codon for glycine-1143 to GAC for aspartate.	Aspartic Acid	63-72	gamma-glutamylcyclotransferase	Homo sapiens	25-28
1619654-6	1992	In intramolecular interactions, the aspartate favours a "side on" geometry, forming hydrogen bonds with N epsilon and N eta 2; in the intermolecular case, however, "end on" contacts involving N eta 1 and N eta 2 of the arginine are preferred.	Aspartic Acid	36-45	secreted phosphoprotein 1	Homo sapiens	194-211
1459319-5	1992	Both diabetic groups displayed a significant enrichment in DQB1 alleles negative for aspartate at position 57 (Type 1b: 83%; Type 1a: 89%; controls 48%; p &lt; 0.001 vs both patient groups) and in DQB1 Asp 57 negative homozygosity: 71% of Type 1b; 80% of Type 1a; 25% of controls (p &lt; 0.01).	Aspartic Acid	202-205	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	59-63
1459319-6	1992	This enrichment in DQB1 Asp 57 negative alleles was accounted for by DQB1* 0201 in the Type 1b group, and by DQB1 % 0201 and 0302 in the Type 1a patients.	Aspartic Acid	24-27	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	19-23
1459319-6	1992	This enrichment in DQB1 Asp 57 negative alleles was accounted for by DQB1* 0201 in the Type 1b group, and by DQB1 % 0201 and 0302 in the Type 1a patients.	Aspartic Acid	24-27	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	69-73
1459319-6	1992	This enrichment in DQB1 Asp 57 negative alleles was accounted for by DQB1* 0201 in the Type 1b group, and by DQB1 % 0201 and 0302 in the Type 1a patients.	Aspartic Acid	24-27	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	69-73
1459319-7	1992	Conversely, alleles DQB1* 0602 and 0301 (DQB1 Asp 57 positive) were protective.	Aspartic Acid	46-49	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	20-24
1459319-7	1992	Conversely, alleles DQB1* 0602 and 0301 (DQB1 Asp 57 positive) were protective.	Aspartic Acid	46-49	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	41-45
1385391-9	1992	An oligopeptide containing the sequence around Thr-19 of bovine myelin basic protein, Lys-Tyr-Leu-Ala-Ser-Ala-Ser-Thr(19)-Met-Asp-His-Ala, can be used as a substrate for selective assaying of the yeast PKC.	Aspartic Acid	126-129	myelin basic protein	Bos taurus	64-84
1506827-2	1992	The correlation of D/L ratio of aspartic acid with actual age gave the following parameters: r = 0.928, sigma = +/- 5.2, k = 4.47 x 10(-4) yr-1 in enamel and r = 0.995, sigma = +/- 1.4, k = 5.75 x 10(-4) yr-1.	Aspartic Acid	32-45	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	104-117
1352447-5	1992	In the liver the inherent H(+)-sensitivity of 2-OGDH is masked by the pH-sensitivity of GOT and the glutamate-aspartate carrier.	Aspartic Acid	110-119	oxoglutarate dehydrogenase	Homo sapiens	48-52
1378072-5	1992	Binding to fibronectin was blocked by a synthetic peptide containing the sequence Arg-Gly-Asp.	Aspartic Acid	90-93	fibronectin 1	Rattus norvegicus	11-22
1629222-7	1992	Expression of a third furin construct containing a mutation of the active site aspartate (Asp153----Asn) similarly resulted in the expression of only the 96-kDa protein, suggesting that furin activation occurs by an autoproteolytic cleavage.	Aspartic Acid	79-88	furin, paired basic amino acid cleaving enzyme	Homo sapiens	22-27
1629222-7	1992	Expression of a third furin construct containing a mutation of the active site aspartate (Asp153----Asn) similarly resulted in the expression of only the 96-kDa protein, suggesting that furin activation occurs by an autoproteolytic cleavage.	Aspartic Acid	79-88	furin, paired basic amino acid cleaving enzyme	Homo sapiens	186-191
1632660-5	1992	The adherence of synovial cells to hyaluronidase treated cartilage slices in vitro was specifically inhibited by the synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro, which is the adhesive portion of the fibronectin molecule.	Aspartic Acid	148-151	fibronectin 1	Homo sapiens	198-209
1459318-3	1992	A significant enrichment in DQB1 alleles encoding for an aminoacid different from Aspartic acid at position 57 (NA) was observed in diabetic (n = 213) in comparison to control (n = 93) children (94% vs 52%; p &lt; 10(-8)).	Aspartic Acid	82-95	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	28-32
1459319-5	1992	Both diabetic groups displayed a significant enrichment in DQB1 alleles negative for aspartate at position 57 (Type 1b: 83%; Type 1a: 89%; controls 48%; p &lt; 0.001 vs both patient groups) and in DQB1 Asp 57 negative homozygosity: 71% of Type 1b; 80% of Type 1a; 25% of controls (p &lt; 0.01).	Aspartic Acid	85-94	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	59-63
1618747-3	1992	We examined the role of the transmembrane domain in regulating insulin receptor signaling by inserting a negatively charged amino acid (Asp) for Val938 (V938D).	Aspartic Acid	136-139	insulin receptor	Cricetulus griseus	63-79
1283100-6	1992	IGFBP-3 and -4 are glycosylated, whereas IGFBP-1 and -2 contain an Arg-Gly-Asp sequence near the carboxyl terminus.	Aspartic Acid	75-78	insulin like growth factor binding protein 1	Homo sapiens	41-55
1352271-2	1992	The GC2 and GC1F phenotypes have an aspartic acid residue at amino acid position 416, whereas the GC1S phenotype has a glutamic acid at this position.	Aspartic Acid	36-49	solute carrier family 25 member 18	Homo sapiens	4-7
1600937-4	1992	We show that some mutant IL-2 proteins with substitutions of a critical Asp residue in the N-terminal alpha-helix bind the mutant IL-2R beta receptor with a higher affinity than the wild-type receptor.	Aspartic Acid	72-75	interleukin 2	Homo sapiens	25-29
1600937-4	1992	We show that some mutant IL-2 proteins with substitutions of a critical Asp residue in the N-terminal alpha-helix bind the mutant IL-2R beta receptor with a higher affinity than the wild-type receptor.	Aspartic Acid	72-75	interleukin 2 receptor subunit beta	Homo sapiens	130-140
1303173-1	1992	The high prevalence of glucose 6-phosphate dehydrogenase (G6PD) deficiency in African populations is due almost entirely to the enzyme variant A-, which differs from the wild-type G6PD B by two amino acid replacements, 68 Val--&gt;Met and 126 Asn--&gt;Asp.	Aspartic Acid	252-255	glucose-6-phosphate dehydrogenase	Homo sapiens	58-62
1303173-2	1992	The non-deficient polymorphic variant G6PD A contains only the mutation 126 Asn--&gt;Asp.	Aspartic Acid	85-88	glucose-6-phosphate dehydrogenase	Homo sapiens	38-42
1597855-3	1992	Incorporation of the tripeptide sequence Arg-Gly-Asp (RGD), a common structural element of many integrin ligands, into cyclic peptides produced a series of peptides of the general structure BrAc-(AA1)-RGD-Cys-OH, which were prepared by solid-phase peptide synthesis.	Aspartic Acid	49-52	AA1	Homo sapiens	196-199
1317379-8	1992	PilR contains the amino-terminal aspartic acid residues which are conserved among the response regulators, suggesting that pilin gene transcription is regulated via a phosphotransfer mechanism in which PilR is phosphorylated by an as yet unidentified protein kinase.	Aspartic Acid	33-46	IncI1 plasmid conjugative transfer inner membrane protein PilR	Pseudomonas aeruginosa	0-4
1317379-8	1992	PilR contains the amino-terminal aspartic acid residues which are conserved among the response regulators, suggesting that pilin gene transcription is regulated via a phosphotransfer mechanism in which PilR is phosphorylated by an as yet unidentified protein kinase.	Aspartic Acid	33-46	IncI1 plasmid conjugative transfer inner membrane protein PilR	Pseudomonas aeruginosa	202-206
1382726-7	1992	Peptides from plasmin digestion of fibronectin containing cell attachment site with sequence Arg-Gly-Asp-Ser and also synthetic peptide reproducing this amino-acid sequence at the concentration of 1000 micrograms/ml released about 50% of collagenase and 55% of elastase from PMN-leukocytes.	Aspartic Acid	101-104	plasminogen	Homo sapiens	14-21
1597416-5	1992	Compression of the range of respiratory control resulting from deletion of the receiver domain and the importance of the conserved Asp-533 and Asp-576 therein suggest that the domain has a kinetic regulatory role in ArcB.	Aspartic Acid	131-134	hypothetical protein	Escherichia coli	216-220
1597416-5	1992	Compression of the range of respiratory control resulting from deletion of the receiver domain and the importance of the conserved Asp-533 and Asp-576 therein suggest that the domain has a kinetic regulatory role in ArcB.	Aspartic Acid	143-146	hypothetical protein	Escherichia coli	216-220
1375964-1	1992	A series of Boc-CCK-4 derivatives represented by the general structure Boc-Trp-Lys(N epsilon-COR)-Asp-Phe-NH2, where R is an aromatic, heterocyclic, or aliphatic group, are potent and selective CCK-A receptor agonists.	Aspartic Acid	98-101	protein tyrosine kinase 7 (inactive)	Homo sapiens	16-21
1376108-4	1992	studies undertaken on antigenic 20- and 11-amino acid fragments of the PEM core protein in dimethyl sulphoxide have identified a type-I beta-turn to be present in the region Pro1-Asp-Thr-Arg4.	Aspartic Acid	179-182	lamin A/C	Homo sapiens	174-178
1599944-3	1992	When apo-TnC is titrated with mastoparan, line-broadening is observed for the ring-current shifted resonance of Phe-23, Ile-34, Val-62 and Phe-72 and the downfield-shifted CH alpha-resonances of Asp-33, Thr-69 and Asp-71; these residues are located in the N-domain.	Aspartic Acid	195-198	tenascin	Oryctolagus cuniculus	9-12
1599944-3	1992	When apo-TnC is titrated with mastoparan, line-broadening is observed for the ring-current shifted resonance of Phe-23, Ile-34, Val-62 and Phe-72 and the downfield-shifted CH alpha-resonances of Asp-33, Thr-69 and Asp-71; these residues are located in the N-domain.	Aspartic Acid	214-217	tenascin	Oryctolagus cuniculus	9-12
1349603-3	1992	Previous studies on human ferredoxin, in which acidic residues were replaced with neutral amino acids, established that Asp-76 and Asp-79 are are important for binding to both reductase and P450 (Coghlan, V. M., and Vickery, L. E. (1991) J. Biol.	Aspartic Acid	120-123	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	190-194
1577789-7	1992	However, the Arg-Gly-Asp-containing synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro significantly inhibited cell attachment to MGP, whereas the control peptide Gly-Arg-Gly-Glu-Ser-Pro had minimal effect.	Aspartic Acid	21-24	matrix Gla protein	Bos taurus	121-124
1577789-8	1992	These data indicate that MGP may function in mediating cell attachment to the extracellular matrix via a receptor that requires intact Gla residues and that can be inhibited by Arg-Gly-Asp-containing peptides.	Aspartic Acid	185-188	matrix Gla protein	Bos taurus	25-28
1316608-5	1992	A comparison of the pRB binding sites of the sequenced genital tract HPVs revealed a consistent amino acid difference (aspartic acid/glycine) between the high-risk and low-risk viruses.	Aspartic Acid	119-132	RB transcriptional corepressor 1	Homo sapiens	20-23
1349603-3	1992	Previous studies on human ferredoxin, in which acidic residues were replaced with neutral amino acids, established that Asp-76 and Asp-79 are are important for binding to both reductase and P450 (Coghlan, V. M., and Vickery, L. E. (1991) J. Biol.	Aspartic Acid	131-134	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	190-194
1374027-3	1992	Two mutants (Ser29 substituted by Arg-Leu-Pro-Gly, and Ser33 substituted by Cys-Gly-Asp) represent two naturally occurring variants of IGF II.	Aspartic Acid	84-87	insulin like growth factor 2	Homo sapiens	135-141
1421803-1	1992	Analysis of well resolved x-ray crystal structure data of proteins (Brookhaven protein data bank) has been combined with molecular mechanics methods using MM2, to determine possible bioactive conformations for the sequence Arg-Gly-Asp, which is believed to be involved in interactions of adhesive proteins with the glycoprotein complexes on activated platelets.	Aspartic Acid	231-234	PNMA family member 2	Homo sapiens	155-158
1314130-6	1992	This mutation was a G to A transition in position 2 of codon 12, substituting aspartate (GAT) for glycine (GGT).	Aspartic Acid	78-87	glycine-N-acyltransferase	Homo sapiens	89-92
1521722-1	1992	Although HLA-DQB1 alleles encoding aspartic acid at position 57 (Asp-57) are protective against Type 1 (insulin-dependent) diabetes mellitus in Caucasians, most Japanese Type 1 diabetic patients carry at least one Asp-57 DQB1 allele.	Aspartic Acid	35-48	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	9-17
1521722-1	1992	Although HLA-DQB1 alleles encoding aspartic acid at position 57 (Asp-57) are protective against Type 1 (insulin-dependent) diabetes mellitus in Caucasians, most Japanese Type 1 diabetic patients carry at least one Asp-57 DQB1 allele.	Aspartic Acid	35-48	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	13-17
1521722-1	1992	Although HLA-DQB1 alleles encoding aspartic acid at position 57 (Asp-57) are protective against Type 1 (insulin-dependent) diabetes mellitus in Caucasians, most Japanese Type 1 diabetic patients carry at least one Asp-57 DQB1 allele.	Aspartic Acid	65-68	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	9-17
1521722-1	1992	Although HLA-DQB1 alleles encoding aspartic acid at position 57 (Asp-57) are protective against Type 1 (insulin-dependent) diabetes mellitus in Caucasians, most Japanese Type 1 diabetic patients carry at least one Asp-57 DQB1 allele.	Aspartic Acid	65-68	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	13-17
1521722-1	1992	Although HLA-DQB1 alleles encoding aspartic acid at position 57 (Asp-57) are protective against Type 1 (insulin-dependent) diabetes mellitus in Caucasians, most Japanese Type 1 diabetic patients carry at least one Asp-57 DQB1 allele.	Aspartic Acid	214-217	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	9-17
1521722-1	1992	Although HLA-DQB1 alleles encoding aspartic acid at position 57 (Asp-57) are protective against Type 1 (insulin-dependent) diabetes mellitus in Caucasians, most Japanese Type 1 diabetic patients carry at least one Asp-57 DQB1 allele.	Aspartic Acid	214-217	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	13-17
1312801-5	1992	The deleterious effects of CCl4 on mitochondrial function were also reflected as a deficient activity of the malate-aspartate shuttle that correlated with abnormal distribution of cholesterol and phospholipids in membranes obtained from submitochondrial particles.	Aspartic Acid	116-125	C-C motif chemokine ligand 4	Rattus norvegicus	27-31
1551892-6	1992	13C NMR studies using 18O-labeled L-aspartic acid demonstrate that glycoasparaginase catalyzes an oxygen exchange between water and the carboxyl group at C-4 of L-aspartic acid.	Aspartic Acid	34-49	complement C4A (Rodgers blood group)	Homo sapiens	154-157
1551892-6	1992	13C NMR studies using 18O-labeled L-aspartic acid demonstrate that glycoasparaginase catalyzes an oxygen exchange between water and the carboxyl group at C-4 of L-aspartic acid.	Aspartic Acid	161-176	complement C4A (Rodgers blood group)	Homo sapiens	154-157
1560020-4	1992	Excellent electron density could be traced for the decapeptide, beginning with Asp-7f and ending with Arg-16f in the active site of thrombin; the remaining 4 residues, which have been cleaved from the tetradecapeptide at the Arg-16f/Gly-17f bond, are not seen.	Aspartic Acid	79-82	coagulation factor II, thrombin	Homo sapiens	132-140
1428526-0	1992	Degradation of aspartic acid and asparagine residues in human growth hormone-releasing factor.	Aspartic Acid	15-28	growth hormone releasing hormone	Homo sapiens	62-93
1572651-8	1992	All of the PSGs except PSG1, PSG4, and PSG8 contained the arginine-glycine-aspartic acid sequence at position 93-95 corresponding to the complementarity determining region 3 of immunoglobulin.	Aspartic Acid	75-88	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	23-27
1572651-8	1992	All of the PSGs except PSG1, PSG4, and PSG8 contained the arginine-glycine-aspartic acid sequence at position 93-95 corresponding to the complementarity determining region 3 of immunoglobulin.	Aspartic Acid	75-88	pregnancy specific beta-1-glycoprotein 4	Homo sapiens	29-33
1572651-8	1992	All of the PSGs except PSG1, PSG4, and PSG8 contained the arginine-glycine-aspartic acid sequence at position 93-95 corresponding to the complementarity determining region 3 of immunoglobulin.	Aspartic Acid	75-88	pregnancy specific beta-1-glycoprotein 8	Homo sapiens	39-43
1624955-1	1992	Many adhesive proteins present in extracellular matrices and in blood contain the tetrapeptide sequence -Arg-Gly-Asp-Ser- (or RGDS) at their cell recognition site.	Aspartic Acid	113-116	ral guanine nucleotide dissociation stimulator	Homo sapiens	126-130
1551832-9	1992	Although the aspartate-containing inner membrane sorting sequence causes an almost quantitative localization to the inner membrane when fused to the otherwise soluble protein beta-lactamase, this sequence cannot prevent significant outer membrane localization when fused to proteins (bacteriocin release protein and OmpA) normally found in the outer membrane.	Aspartic Acid	13-22	beta-lactamase	Escherichia coli	175-189
1372338-4	1992	Three of these polypeptides--54, 93, and 125 kDa--were biologically active in promoting cell attachment and were recognized by monoclonal antibodies that bind fibronectin near the arg-gly-asp (RGD) domain.	Aspartic Acid	188-191	fibronectin 1	Homo sapiens	159-170
1314909-4	1992	Taking advantage of the heterogeneity that occurs primarily in silent sites of the COI DNA sequences, amino acid assignments of several codons have been deduced as nonuniversal: UGA = Trp, AAA = Asp, and AGR (R: A or G) = Ser.	Aspartic Acid	195-198	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	83-86
1409546-5	1992	Sequencing the plasmid DNA encoding this mutant protein showed that the histidine at position 111 of native human IFN gamma is changed to aspartic acid (IFN gamma/H111D).	Aspartic Acid	138-151	interferon gamma	Homo sapiens	114-123
1584723-5	1992	Specifically, infants with the amino acid sequence -asp-glu-ala-val- at DPB1 positions #84-87 are more likely to be infected (P = 0.001) and infants with the allele DQA1*0102 are less likely to be infected (P = 0.031).	Aspartic Acid	52-55	major histocompatibility complex, class II, DP beta 1	Homo sapiens	72-76
1584723-5	1992	Specifically, infants with the amino acid sequence -asp-glu-ala-val- at DPB1 positions #84-87 are more likely to be infected (P = 0.001) and infants with the allele DQA1*0102 are less likely to be infected (P = 0.031).	Aspartic Acid	52-55	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	165-169
1409546-5	1992	Sequencing the plasmid DNA encoding this mutant protein showed that the histidine at position 111 of native human IFN gamma is changed to aspartic acid (IFN gamma/H111D).	Aspartic Acid	138-151	interferon gamma	Homo sapiens	114-119
1557428-11	1992	In the cytoplasm the aspartate is converted to fumarate utilizing urea cycle enzymes; the fumarate flows via oxaloacetate to PEP and on to glucose.	Aspartic Acid	21-30	progestagen associated endometrial protein	Homo sapiens	125-128
1556130-6	1992	Lastly, attachment of the specific ER retention signal KDEL (Lys-Asp-Glu-Leu) to the carboxyl terminus of LPL also resulted in intracellularly retained enzyme that was fully active.	Aspartic Acid	65-68	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	106-109
1349253-4	1992	Injection of 20 nmol of DYN caused permanent paralysis and neuronal cell loss in all animals tested as well as a significant increase of Asp and Glu in both the ECF and the CSF, and a decrease in glutamine (Gln) release only in the ECF.	Aspartic Acid	137-140	prodynorphin	Mus musculus	24-27
1532572-8	1992	Both alpha v beta 6 and alpha v beta 5 are eluted from their respective immobilized ligands by a hexa-peptide containing the sequence Arg-Gly-Asp (RGD).	Aspartic Acid	142-145	adaptor related protein complex 5 subunit beta 1	Homo sapiens	32-38
1547341-0	1992	Antithrombin-III-Stockholm: a codon 392 (Gly----Asp) mutation with normal heparin binding and impaired serine protease reactivity.	Aspartic Acid	48-51	serpin family C member 1	Homo sapiens	0-16
1544468-7	1992	The results obtained for human pancreatic lipase corroborate the inhibition mechanism of THL found on the porcine enzyme, and are in full agreement with the identification of the Ser-152 ... His-263 ... Asp-176 catalytic triad in the X-ray structure of human pancreatic lipase.	Aspartic Acid	203-206	pancreatic lipase	Homo sapiens	31-48
1544468-7	1992	The results obtained for human pancreatic lipase corroborate the inhibition mechanism of THL found on the porcine enzyme, and are in full agreement with the identification of the Ser-152 ... His-263 ... Asp-176 catalytic triad in the X-ray structure of human pancreatic lipase.	Aspartic Acid	203-206	pancreatic lipase	Homo sapiens	259-276
1547341-0	1992	Antithrombin-III-Stockholm: a codon 392 (Gly----Asp) mutation with normal heparin binding and impaired serine protease reactivity.	Aspartic Acid	48-51	coagulation factor II, thrombin	Homo sapiens	103-118
1551498-1	1992	Insulin-dependent diabetes mellitus (IDDM) in whites is strongly associated with particular HLA-DQ alpha beta heterodimers composed of a DQ alpha chain with an arginine at residue 52 (Arg52+) combined to a DQ beta chain lacking an aspartic acid at residue 57 (Asp57-).	Aspartic Acid	231-244	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	92-95
1552943-6	1992	Cloning and sequencing of PMP-22 complementary DNAs from inbred Tr mice reveals a point mutation that substitutes an aspartic acid residue for a glycine in a putative membrane-associated domain of the PMP-22 protein.	Aspartic Acid	117-130	peripheral myelin protein 22	Mus musculus	26-32
1552943-6	1992	Cloning and sequencing of PMP-22 complementary DNAs from inbred Tr mice reveals a point mutation that substitutes an aspartic acid residue for a glycine in a putative membrane-associated domain of the PMP-22 protein.	Aspartic Acid	117-130	peripheral myelin protein 22	Mus musculus	201-207
1610377-5	1992	The mixture with Asp as the fifth residue inhibited platelet adhesion to fibronectin more effectively than the other mixtures.	Aspartic Acid	17-20	fibronectin 1	Homo sapiens	73-84
1348712-5	1992	Hybridization with sequence-specific oligonucleotide probes for DQB1 alleles showed homozygosity of aspartic acid at position 57 in 7 of 10 malnutrition-related diabetic patients compared to 2 of 10 Type 1 diabetic (p less than 0.05) and 15 of 45 control subjects (p less than 0.05).	Aspartic Acid	100-113	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	64-68
1348712-7	1992	This study has confirmed the association of DQB1 57 non-asp in South Indians with Type 1 diabetes.	Aspartic Acid	56-59	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	44-48
1544488-3	1992	These results indicate that matrix assembly of fibronectin requires both regions and can proceed in the absence of the type III repeats including the one containing the cell adhesive Arg-Gly-Asp sequence.	Aspartic Acid	191-194	fibronectin 1	Homo sapiens	47-58
1346338-7	1992	In the family with fatal familial insomnia, all 4 affected members and 11 of the 29 unaffected members had a point mutation in PrP codon 178 that results in the substitution of asparagine for aspartic acid and elimination of the Tth111 I restriction site.	Aspartic Acid	192-205	prion protein	Homo sapiens	127-130
1545235-2	1992	The deduced protein is structurally similar to the yeast KEX2 prohormone endoprotease including the conserved Asp, His, and Ser catalytic triad residues characteristic of the subtilisin family.	Aspartic Acid	110-113	kexin KEX2	Saccharomyces cerevisiae S288C	57-61
1371284-4	1992	Based on primary sequence homology of LPL to pancreatic lipase, Ser-132, Asp-156, and His-241 have been proposed to be part of a domain required for normal enzymic activity.	Aspartic Acid	73-76	lipoprotein lipase	Homo sapiens	38-41
1371284-9	1992	In summary, mutation of Ser-132, Asp-156, and His-241 specifically abolishes total hydrolytic activity without disrupting other important functional domains of LPL.	Aspartic Acid	33-36	lipoprotein lipase	Homo sapiens	160-163
1371284-10	1992	These combined results strongly support the conclusion that Ser-132, Asp-156, and His-241 form the catalytic triad of LPL and are essential for LPL hydrolytic activity.	Aspartic Acid	69-72	lipoprotein lipase	Homo sapiens	118-121
1371284-10	1992	These combined results strongly support the conclusion that Ser-132, Asp-156, and His-241 form the catalytic triad of LPL and are essential for LPL hydrolytic activity.	Aspartic Acid	69-72	lipoprotein lipase	Homo sapiens	144-147
1737795-2	1992	A glycine to alanine substitution yielded RADS-vWF, while an aspartate to glutamate substitution resulted in RGES-vWF.	Aspartic Acid	61-70	von Willebrand factor	Homo sapiens	114-117
1730390-1	1992	Sequence analysis of cDNA clones encoding fibronectin (FN) from Xenopus laevis reveals extensive amino acid identities with other vertebrate FNs, including the presence of the Arg-Gly-Asp (RGD) cell attachment site in type III-10 and of a second, cell-binding site (EILDV) in the alternative spliced V region of the protein.	Aspartic Acid	184-187	fibronectin 1 S homeolog	Xenopus laevis	42-53
1739968-5	1992	The Asp-51 substitution mimics the phosphorylated state and derepresses GCN4 in the absence of GCN2.	Aspartic Acid	4-7	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	72-76
1371469-3	1992	Activation of these autoreactive cells requires the use of the vitronection receptor (VNR) as an accessory molecule which interacts with the Arg-Gly-Asp-Ser (RGDS) sequence of extracellular matrix (ECM) proteins.	Aspartic Acid	149-152	ral guanine nucleotide dissociation stimulator	Mus musculus	158-162
1370813-9	1992	Structural comparison of serine proteases (i.e. acyl-amino acid hydrolase or prolyl endopeptidase) with the most conserved domain of THAM identified a stretch of 200 amino acids containing a putative catalytic triad arranged in a novel topological order (Ser-624, Asp-702, and His-734) thereby defining a subfamily of nonclassical serine proteases.	Aspartic Acid	264-267	prolyl endopeptidase	Mus musculus	77-97
1370813-9	1992	Structural comparison of serine proteases (i.e. acyl-amino acid hydrolase or prolyl endopeptidase) with the most conserved domain of THAM identified a stretch of 200 amino acids containing a putative catalytic triad arranged in a novel topological order (Ser-624, Asp-702, and His-734) thereby defining a subfamily of nonclassical serine proteases.	Aspartic Acid	264-267	dipeptidylpeptidase 4	Mus musculus	133-137
1537377-0	1992	Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen.	Aspartic Acid	66-69	endoglin	Homo sapiens	45-53
1730390-1	1992	Sequence analysis of cDNA clones encoding fibronectin (FN) from Xenopus laevis reveals extensive amino acid identities with other vertebrate FNs, including the presence of the Arg-Gly-Asp (RGD) cell attachment site in type III-10 and of a second, cell-binding site (EILDV) in the alternative spliced V region of the protein.	Aspartic Acid	184-187	fibronectin 1 S homeolog	Xenopus laevis	55-57
1558877-2	1992	The C-terminal and the N-terminal amino acid sequences of the low-molecular-mass protein A were -Asn-Ala-Phe and Ala-Gln-His-Asp-Glu-Ala-Gln-, respectively.	Aspartic Acid	125-128	G protein-coupled receptor 162	Gallus gallus	81-90
1311931-2	1992	A comparison of all known beta amino acid sequences shows that an aspartic acid at position 99 (with the numbering scheme for hCG-beta) is one of the seven non-Cys invariant residues.	Aspartic Acid	66-79	chorionic gonadotropin subunit beta 3	Homo sapiens	126-134
1346132-6	1992	The maternal defect was shown to be a frameshift mutation with the deletion of a single T in the aspartic acid codon at position 690 (GAT), 11 amino acids N-terminal to the beginning of the transmembrane domain.	Aspartic Acid	97-110	glycine-N-acyltransferase	Homo sapiens	134-137
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Aspartic Acid	154-167	integrin subunit alpha 2b	Homo sapiens	4-10
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Aspartic Acid	154-167	fibrinogen beta chain	Homo sapiens	203-213
1730727-0	1992	Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the proposed catalytic triad of human lipoprotein lipase.	Aspartic Acid	73-86	lipoprotein lipase	Homo sapiens	132-150
1730727-9	1992	The two naturally occurring mutations, which both alter the same aspartic acid residue in the proposed Asp156-His241-Ser132 catalytic triad of human LPL, indicate that Asp156 plays a significant role in LPL catalysis.	Aspartic Acid	65-78	lipoprotein lipase	Homo sapiens	149-152
1730727-9	1992	The two naturally occurring mutations, which both alter the same aspartic acid residue in the proposed Asp156-His241-Ser132 catalytic triad of human LPL, indicate that Asp156 plays a significant role in LPL catalysis.	Aspartic Acid	65-78	lipoprotein lipase	Homo sapiens	203-206
1317143-2	1992	The consensus sequence from the second sample contained a unique double mutation (ACT to GAT) in the codon for reverse transcriptase amino acid 69, causing substitution of aspartic acid (Asp) for the wild-type threonine (Thr).	Aspartic Acid	172-185	glycine-N-acyltransferase	Homo sapiens	89-92
1362860-2	1992	The deduced amino acid sequence shows a high degree of identity to LPL from other species, and contains the Ser/His/Asp triade characteristic of serine proteases and esterases.	Aspartic Acid	116-119	lipoprotein lipase	Homo sapiens	67-70
1317143-2	1992	The consensus sequence from the second sample contained a unique double mutation (ACT to GAT) in the codon for reverse transcriptase amino acid 69, causing substitution of aspartic acid (Asp) for the wild-type threonine (Thr).	Aspartic Acid	187-190	glycine-N-acyltransferase	Homo sapiens	89-92
27286379-5	1992	On the other hand, pancreatic lipase activity was stimulated by not only BSA, but L-histidine and L-aspartic acid as N-end amino groups of BSA and additionally accelerated it in combination with bile salts.	Aspartic Acid	98-113	pancreatic lipase	Homo sapiens	19-36
1567180-6	1992	Although the function of this protein in tumor cells is not known, OPN contains a conserved GRGDS (glycine-arginine-glycine-aspartic acid-serine) amino acid sequence, which may function as a cell attachment site for this protein.	Aspartic Acid	124-137	secreted phosphoprotein 1	Mus musculus	67-70
1350965-4	1992	The levels of aspartate, glutamate, glycine, and taurine were elevated in the CSF during myoclonic jerks and more distinctly immediately after GC.	Aspartic Acid	14-23	colony stimulating factor 2	Rattus norvegicus	78-81
1312207-4	1992	This protein which we call CBP-58 bears similarities to the endoplasmic reticulum protein, calreticulin, in that it has a pI of 4.7 containing approximately 30% glutamate and aspartate, has a high capacity for calcium, and stains blue with the carbocyanine dye, "Stains-all".	Aspartic Acid	175-184	calreticulin	Bos taurus	91-103
1301189-0	1992	A glycine250--&gt; aspartate substitution in the alpha-subunit of hexosaminidase A causes juvenile-onset Tay-Sachs disease in a Lebanese-Canadian family.	Aspartic Acid	19-28	hexosaminidase subunit alpha	Homo sapiens	66-82
1347765-4	1992	The frequency of DQB1 genotypes encoding the amino acid aspartic acid at position 57 of the DQ beta chain did not differ significantly between subjects with insulin-dependent diabetes mellitus (IDDM) and controls.	Aspartic Acid	56-69	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	17-21
1611033-1	1992	Tyrosine 109 in the acetylcholinesterase sequence of Drosophila melanogaster corresponds to an aspartate in vertebrate cholinesterases.	Aspartic Acid	95-104	Acetylcholine esterase	Drosophila melanogaster	20-40
1740757-5	1992	Residue 54 of BH8 nef is an aspartic acid, whereas that of BRU is alanine.	Aspartic Acid	28-41	S100 calcium binding protein B	Homo sapiens	18-21
1740757-9	1992	Nef proteins that contain an aspartic acid at residue 54 migrate as 27-kDa proteins, whereas those that contain alanine at residue 54 migrate as 25-kDa proteins.	Aspartic Acid	29-42	S100 calcium binding protein B	Homo sapiens	0-3
1403344-0	1992	User-defined serum aspartate and alanine aminotransferase, cholesterol, triglycerides, urea, and uric acid for the Beckman synchron CX 4/5 using Ames Sera-Pak reagents.	Aspartic Acid	19-28	gap junction protein gamma 1	Homo sapiens	132-138
1327034-8	1992	Colon cancer is mainly associated with mutations leading to substitution of the normal glycine at amino acid position 12 of K-ras by either valine or aspartic acid, and mutations in N-ras are not exceptional.	Aspartic Acid	150-163	KRAS proto-oncogene, GTPase	Homo sapiens	124-129
1353619-11	1992	Acetylcholinesterase also enhanced the response of Purkinje cells to the excitatory amino acids glutamate and aspartate thought to be transmitters in the cerebellar cortex.	Aspartic Acid	110-119	acetylcholinesterase	Cavia porcellus	0-20
1371492-4	1992	We used the peptide Trp-Thr-Val-Pro-Thr-Ala, WTVPTA (deduced from the complementary nucleotide sequence to that which codes for the Arg-Gly-Asp, RGD, domain in fibronectin), to test the immunologic activity of ITP sera.	Aspartic Acid	140-143	fibronectin 1	Homo sapiens	160-171
1729196-5	1992	An immobilized preparation of the enzyme cleaved glycophorin A at several positions, with a major site of cleavage at Arg-31-Asp-32.	Aspartic Acid	125-128	glycophorin A (MNS blood group)	Homo sapiens	49-62
1728638-5	1992	Pre-treatment of cells with 25-250 micrograms/ml of synthetic peptides containing the fibronectin cell-recognition sequence RGD (Arg-Gly-Asp) resulted in a concentration-dependent inhibition of fibronectin-mediated chemotaxis, whereas chemotaxis to collagen was not affected.	Aspartic Acid	137-140	fibronectin 1	Homo sapiens	86-97
1728638-5	1992	Pre-treatment of cells with 25-250 micrograms/ml of synthetic peptides containing the fibronectin cell-recognition sequence RGD (Arg-Gly-Asp) resulted in a concentration-dependent inhibition of fibronectin-mediated chemotaxis, whereas chemotaxis to collagen was not affected.	Aspartic Acid	137-140	fibronectin 1	Homo sapiens	194-205
1542405-2	1992	The drug BC264 (Boc-Tyr(SO3H)-gNle-mGly-Trp-(NMe)Nle-Asp-Phe-NH2), a highly potent and selective CCK-B agonist, injected into the postero-median or antero-median n. accumbens did not modify the spontaneous alternation and exploratory behaviour observed in a Y-maze.	Aspartic Acid	53-56	cholecystokinin	Rattus norvegicus	97-100
1355306-3	1992	We have shown a strong positive association between IDDM and the Asp 57- DQB1 allele *0201 (DQw2).	Aspartic Acid	65-68	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	73-77
1355306-5	1992	We can now confirm that the association between Asp 57- DQB1 alleles and IDDM, previously reported in ethnically diverse cohorts collected in Western Europe, North America, and South Asia, is also present in an IDDM cohort collected in Africa.	Aspartic Acid	48-51	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	56-60
1764061-0	1991	Characterization of an isoelectric focusing variant of SAA1 (ASP-72) in a family of Turkish origin.	Aspartic Acid	61-64	serum amyloid A1	Homo sapiens	55-59
1764061-4	1991	The presence of both bases predicts two SAA1 protein sequences, one having aspartic acid and the other glycine at position 72.	Aspartic Acid	75-88	serum amyloid A1	Homo sapiens	40-44
1660887-13	1991	Furthermore, fusion of the UBC4 acidic extension to the C terminus of UBC1 resulted in a chimeric protein capable of efficient histone conjugation, as did fusion of short tracts of alternating aspartate and glutamate residues.	Aspartic Acid	193-202	ubiquitin-conjugating enzyme E2 2	Triticum aestivum	70-74
1756856-3	1991	APA, which splits off the N-terminal Asp from angiotensin II (AII), was present at the surface of HGECs (55% of the total enzyme).	Aspartic Acid	37-40	glutamyl aminopeptidase	Homo sapiens	0-3
1722316-5	1991	The most common escape mutation was an amino acid change of asparagine (AAT) to aspartic acid (GAT) at position 280; an additional mutation was glycine (GGT) to aspartic acid (GAT) at position 282.	Aspartic Acid	80-93	glycine-N-acyltransferase	Homo sapiens	95-98
1722316-5	1991	The most common escape mutation was an amino acid change of asparagine (AAT) to aspartic acid (GAT) at position 280; an additional mutation was glycine (GGT) to aspartic acid (GAT) at position 282.	Aspartic Acid	161-174	glycine-N-acyltransferase	Homo sapiens	176-179
1660723-1	1991	The double charge, aspartic acid to lysine, point mutations were constructed at positions 37, 79, and 217 on the surface of cytochrome c peroxidase, sites purported to be within or proximal to the recognition site for cytochrome c in an electron-transfer productive complex formed by the two proteins.	Aspartic Acid	19-32	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	124-147
1756856-3	1991	APA, which splits off the N-terminal Asp from angiotensin II (AII), was present at the surface of HGECs (55% of the total enzyme).	Aspartic Acid	37-40	angiotensinogen	Homo sapiens	62-65
1756904-1	1991	It has been proposed that negatively charged aspartic acid at position 57 of the HLA-DQ beta-chain determines resistance to development of insulin-dependent diabetes mellitus (IDDM), whereas genetic susceptibility to IDDM correlates with a neutral amino acid residue.	Aspartic Acid	45-58	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	81-92
1962623-3	1991	The predominant mutation was from glycine (GGT) to aspartic acid (GAT).	Aspartic Acid	51-64	glycine-N-acyltransferase	Homo sapiens	66-69
1797867-5	1991	In this layer, 16.4% of 3H-D-aspartate-labelled perikarya were also stained for CaBP.	Aspartic Acid	29-38	S100 calcium binding protein G	Rattus norvegicus	80-84
1822238-5	1991	These methods were used in a study of O-GlcNAc glycopeptides produced by purified O-GlcNAc transferase addition of GlcNAc to the synthetic peptides YSDSPSTST and YSGSPSTST in which Y is tyrosine, S is serine, D is aspartic acid, P is proline, T is threonine and G is glycine.	Aspartic Acid	214-227	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	38-46
1822238-5	1991	These methods were used in a study of O-GlcNAc glycopeptides produced by purified O-GlcNAc transferase addition of GlcNAc to the synthetic peptides YSDSPSTST and YSGSPSTST in which Y is tyrosine, S is serine, D is aspartic acid, P is proline, T is threonine and G is glycine.	Aspartic Acid	214-227	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	82-90
1718745-4	1991	These results indicate that in heterodimer RT, the p51 component cannot compensate for active site mutations eliminating the activity of p66, indirectly implying that solely the p66 aspartic acid residues of heterodimer are crucial for catalysis.	Aspartic Acid	182-195	tumor protein p63	Homo sapiens	51-54
1718745-4	1991	These results indicate that in heterodimer RT, the p51 component cannot compensate for active site mutations eliminating the activity of p66, indirectly implying that solely the p66 aspartic acid residues of heterodimer are crucial for catalysis.	Aspartic Acid	182-195	DNA polymerase delta 3, accessory subunit	Homo sapiens	137-140
1718745-4	1991	These results indicate that in heterodimer RT, the p51 component cannot compensate for active site mutations eliminating the activity of p66, indirectly implying that solely the p66 aspartic acid residues of heterodimer are crucial for catalysis.	Aspartic Acid	182-195	DNA polymerase delta 3, accessory subunit	Homo sapiens	178-181
1750798-18	1991	For insulin dependent diabetes mellitus it has been shown that the MHC determined susceptibility to the disease is conferred by neutral residues (Val, Ser, Ala), at position 57 of the DQ beta chain, while Asp at this position correlates with resistance.	Aspartic Acid	205-208	major histocompatibility complex, class I, C	Homo sapiens	67-70
1658233-4	1991	The primary structure of the neurokinin B-related peptide was established as: Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2.	Aspartic Acid	78-81	tachykinin precursor 3	Homo sapiens	29-41
1812392-2	1991	administration of ammonium acetate on the activity of the two malate-aspartate shuttle enzymes: aspartate aminotransferase (AAT), malate dehydrogenase (MDH), and on the pyruvate carboxylase (PC) activity were examined in synaptic and nonsynaptic mitochondria from rat brain.	Aspartic Acid	69-78	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	96-122
1812392-2	1991	administration of ammonium acetate on the activity of the two malate-aspartate shuttle enzymes: aspartate aminotransferase (AAT), malate dehydrogenase (MDH), and on the pyruvate carboxylase (PC) activity were examined in synaptic and nonsynaptic mitochondria from rat brain.	Aspartic Acid	69-78	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	124-127
1812395-4	1991	The most likely explanation for increased CSF lactate is ammonia-induced inhibition of malate-aspartate shuttle and/or inhibition of tricarboxylic acid cycle flux in brain.	Aspartic Acid	94-103	colony stimulating factor 2	Homo sapiens	42-45
1657158-1	1991	Twelve amino acid substitutions of varying size and hydrophobicity were constructed at Val 143 in human carbonic anhydrase II (including Gly, Ser, Cys, Asn, Asp, Leu, Ile, His, Phe and Tyr) to examine the catalytic roles of the hydrophobic pocket in the active site of this enzyme.	Aspartic Acid	157-160	carbonic anhydrase 2	Homo sapiens	104-125
1928099-6	1991	This residue occurs within a very highly conserved hydrophilic loop, is invariantly alanine or glycine in all ND1 proteins, and is adjacent to an invariant aspartic acid residue.	Aspartic Acid	156-169	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	110-113
1839957-8	1991	Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser.	Aspartic Acid	138-141	interferon gamma	Homo sapiens	28-37
1839957-8	1991	Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser.	Aspartic Acid	138-141	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	46-49
1839957-8	1991	Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser.	Aspartic Acid	138-141	fibronectin 1	Homo sapiens	29-31
1839957-8	1991	Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser.	Aspartic Acid	138-141	ral guanine nucleotide dissociation stimulator	Homo sapiens	147-151
1961724-2	1991	In the presence of ascorbate and H2O2, an iron chelate attached to Cys-212 of the enzyme human carbonic anhydrase I quickly cleaved the protein between residues Leu-189 and Asp-190 to produce two discrete fragments.	Aspartic Acid	173-176	carbonic anhydrase 1	Homo sapiens	95-115
1681587-3	1991	Electrophysiological recordings made in Xenopus oocytes that express DGluR-II revealed depolarizing responses to L-glutamate and L-aspartate but low sensitivity to quisqualate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate.	Aspartic Acid	129-140	Glutamate receptor IIA	Drosophila melanogaster	69-77
1797805-1	1991	Materials to enhance cell adhesion were synthesized by surface integration of peptide, Arg-Gly-Asp-Ser(RGDS), which is an active-site sequence of cell-adhesive proteins.	Aspartic Acid	95-98	ral guanine nucleotide dissociation stimulator	Homo sapiens	103-107
1658739-7	1991	Strikingly, although 30 amino acids are encoded by each alternative exon, only amino acid position 209 is altered between the two, specifying asparagine in RII and aspartate in RIIA.	Aspartic Acid	164-173	protein kinase cAMP-dependent type I regulatory subunit alpha	Rattus norvegicus	177-181
1717468-0	1991	Arginine-glycine-aspartic acid binding leading to molecular stabilization between integrin alpha v beta 3 and its ligand.	Aspartic Acid	17-30	integrin subunit alpha V	Homo sapiens	82-105
1917982-7	1991	We propose a model in which Fd-reductase and P450scc share a requirement for ferredoxin residues Asp-76 and Asp-79 but have other determinants that differ and play an important role in binding.	Aspartic Acid	97-100	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	45-52
1917982-7	1991	We propose a model in which Fd-reductase and P450scc share a requirement for ferredoxin residues Asp-76 and Asp-79 but have other determinants that differ and play an important role in binding.	Aspartic Acid	108-111	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	45-52
1919001-0	1991	IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.	Aspartic Acid	32-45	interleukin 1 beta	Homo sapiens	77-86
1919001-6	1991	Analysis of human IL-1 beta precursor mutants containing amino acid substitutions or deletions within each processing site demonstrated that omission or replacement of Asp at site 1 or site 2 prevented cleavage by ICE.	Aspartic Acid	168-171	interleukin 1 beta	Homo sapiens	18-27
1919001-6	1991	Analysis of human IL-1 beta precursor mutants containing amino acid substitutions or deletions within each processing site demonstrated that omission or replacement of Asp at site 1 or site 2 prevented cleavage by ICE.	Aspartic Acid	168-171	caspase 1	Homo sapiens	214-217
1919001-12	1991	These results show that ICE is a highly specific IL-1 beta convertase with absolute requirements for Asp in P1 and a small hydrophobic amino acid in P1".	Aspartic Acid	101-104	caspase 1	Homo sapiens	24-27
1919001-12	1991	These results show that ICE is a highly specific IL-1 beta convertase with absolute requirements for Asp in P1 and a small hydrophobic amino acid in P1".	Aspartic Acid	101-104	interleukin 1 beta	Homo sapiens	49-58
1919003-2	1991	Comparison of amino acid sequences of the alpha-chain fragment of C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 are the only consistent structural difference between isotype, i.e., Pro, Cys, Pro, Val, Leu, Asp in C4A and Leu, Ser, Pro, Val Ile, His in C4B.	Aspartic Acid	233-236	complement C4B (Chido blood group)	Homo sapiens	94-97
1657904-0	1991	Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C. The last three consecutive epidermal growth factor (EGF)-like structures of human thrombomodulin constitute the functional domain for protein C-activating cofactor activity and anticoagulant activity.	Aspartic Acid	0-13	epidermal growth factor	Homo sapiens	32-55
1657904-0	1991	Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C. The last three consecutive epidermal growth factor (EGF)-like structures of human thrombomodulin constitute the functional domain for protein C-activating cofactor activity and anticoagulant activity.	Aspartic Acid	0-13	thrombomodulin	Homo sapiens	80-94
1657904-0	1991	Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C. The last three consecutive epidermal growth factor (EGF)-like structures of human thrombomodulin constitute the functional domain for protein C-activating cofactor activity and anticoagulant activity.	Aspartic Acid	0-13	epidermal growth factor	Homo sapiens	180-203
1657904-0	1991	Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C. The last three consecutive epidermal growth factor (EGF)-like structures of human thrombomodulin constitute the functional domain for protein C-activating cofactor activity and anticoagulant activity.	Aspartic Acid	0-13	thrombomodulin	Homo sapiens	235-249
1918051-4	1991	Of the remaining seven conserved amino acid residues, we have investigated the role of an Asp which occurs at position 99 in human choriogonadotropin beta (hCG beta).	Aspartic Acid	90-93	chorionic gonadotropin subunit beta 3	Homo sapiens	156-164
1718779-2	1991	Cyclic Arg-Gly-Asp-Phe-Val peptides with either D-Phe or D-Val residues were 20- to more than 100-fold better inhibitors of cell adhesion to vitronectin and/or laminin fragment P1 when compared to a linear variant or Gly-Arg-Gly-Asp-Ser.	Aspartic Acid	15-18	vitronectin	Homo sapiens	141-152
1718779-2	1991	Cyclic Arg-Gly-Asp-Phe-Val peptides with either D-Phe or D-Val residues were 20- to more than 100-fold better inhibitors of cell adhesion to vitronectin and/or laminin fragment P1 when compared to a linear variant or Gly-Arg-Gly-Asp-Ser.	Aspartic Acid	229-232	vitronectin	Homo sapiens	141-152
1932123-2	1991	Functional domains like the catalytic triad (His-70, Asp-124, Ser-222) are highly conserved not only between the available acrosin primary structures of different mammals but also in comparison with other serine proteinases.	Aspartic Acid	53-56	acrosin	Rattus norvegicus	123-130
1920361-1	1991	The development of potent antithrombotic agents from the fibrinogen platelet receptor binding sequences Fg-alpha 572-575 -Arg-Gly-Asp-Ser- and Fg-gamma 400-411 -HHLGGAKQAGDV, believed to be a cryptic RGD-type sequence, is described.	Aspartic Acid	130-133	fibrinogen beta chain	Homo sapiens	57-67
1930940-5	1991	The search for specific structural changes of the DQA and DQB genes has shown that susceptibility correlates with the absence of aspartic acid at position 57 on the DQ beta chain (DQ beta 57 Asp--) and/or the presence of arginine at position 52 on the DQ alpha chain (DQ alpha 52 Arg+).	Aspartic Acid	129-142	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	58-61
1930940-5	1991	The search for specific structural changes of the DQA and DQB genes has shown that susceptibility correlates with the absence of aspartic acid at position 57 on the DQ beta chain (DQ beta 57 Asp--) and/or the presence of arginine at position 52 on the DQ alpha chain (DQ alpha 52 Arg+).	Aspartic Acid	191-194	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	58-61
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Aspartic Acid	58-61	angiotensinogen	Homo sapiens	41-56
1895386-2	1991	The surface protein gp70 has eight potential attachment sites for N-linked glycan; each signal asparagine was converted to aspartate, and mutant viruses were tested for the ability to grow in NIH 3T3 fibroblasts.	Aspartic Acid	123-132	embigin	Homo sapiens	20-24
1961019-8	1991	Endoglin contains an arginine-glycine-aspartic acid sequence, a feature generally associated with extracellular matrix proteins which interact with integrins.	Aspartic Acid	38-51	endoglin	Homo sapiens	0-8
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Aspartic Acid	35-38	fibrinogen beta chain	Homo sapiens	112-122
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Aspartic Acid	87-90	fibrinogen beta chain	Homo sapiens	112-122
1775137-1	1991	We have identified two different single nucleotide alterations in codon 686 (GAC; aspartic acid) in exon 4 of the human androgen receptor gene in three unrelated families with the complete form of androgen insensitivity.	Aspartic Acid	82-95	androgen receptor	Homo sapiens	120-137
1775137-8	1991	Thus, aspartic acid-686 appears essential for normal androgen receptor function.	Aspartic Acid	6-19	androgen receptor	Homo sapiens	53-70
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Aspartic Acid	56-59	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	165-170
1654318-10	1991	This change in specificity may account for the ability of the receptor to serve as an excellent thrombin substrate despite the presence of an Asp residue in the P3 site, which is normally inhibitory to thrombin activity.	Aspartic Acid	142-145	coagulation factor II, thrombin	Homo sapiens	96-104
1654318-10	1991	This change in specificity may account for the ability of the receptor to serve as an excellent thrombin substrate despite the presence of an Asp residue in the P3 site, which is normally inhibitory to thrombin activity.	Aspartic Acid	142-145	coagulation factor II, thrombin	Homo sapiens	202-210
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Aspartic Acid	56-59	fibronectin 1	Mus musculus	153-155
1684756-8	1991	Molecular genetic studies disclosed a new G-to-A mutation in codon 178 of the PRNP gene (resulting in a substitution of asparagine for aspartic acid) in the DNA of eight family members with CJD but not in any of ten currently healthy first degree relatives of the patients, or 86 controls.	Aspartic Acid	135-148	prion protein	Homo sapiens	78-82
1958054-3	1991	The active form is generated upon proteolytic cleavage of the N-terminal prophospholipase A2 activation peptide (PLAP), with the sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR).	Aspartic Acid	138-141	phospholipase A2 activating protein	Homo sapiens	73-111
1958054-3	1991	The active form is generated upon proteolytic cleavage of the N-terminal prophospholipase A2 activation peptide (PLAP), with the sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR).	Aspartic Acid	138-141	phospholipase A2 activating protein	Homo sapiens	113-117
1717598-7	1991	This was further substantiated by the observation that MON-101 and MON-102 specifically recognized a conjugate between bovine serum albumin and the synthetic peptide Phe-Glu-Pro-Glu-His-Asp-Tyr-Pro-Gly-Leu-Gly-Lys based upon the deduced amino acid sequence of the predicted epitope region in 7B2.	Aspartic Acid	186-189	secretogranin V	Rattus norvegicus	292-295
1885608-8	1991	We converted yeast actin to a class II species by inserting a Cys codon between the Met-1 and Asp-2 codons.	Aspartic Acid	94-97	actin	Saccharomyces cerevisiae S288C	19-24
1887879-13	1991	The stimulatory effects of vasopressin on the malate-aspartate shuttle were also inhibited by W-7, trifluoperazine, and chlorpromazine.	Aspartic Acid	53-62	arginine vasopressin	Rattus norvegicus	27-38
1887879-14	1991	The results suggest that the malate-aspartate shuttle may be regulated by Ca(2+)-calmodulin.	Aspartic Acid	36-45	calmodulin 1	Rattus norvegicus	81-91
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Aspartic Acid	126-129	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-33
1937565-7	1991	One site on the Fn molecule known to interact with phagocytic cells is the cell-binding domain containing the Arg-Gly-Asp (RGD) sequence.	Aspartic Acid	118-121	fibronectin 1	Homo sapiens	16-18
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Aspartic Acid	126-129	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-74
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Aspartic Acid	126-129	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-74
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Aspartic Acid	126-129	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-74
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Aspartic Acid	142-145	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-33
1883366-5	1991	Since aspartate accumulation directly reflects fluxes of alanine through pyruvate carboxylase, the observed increase in hepatic production of [3-13C]-aspartate in tumor rats indicates that pyruvate carboxylase activity is significantly enhanced.	Aspartic Acid	6-15	pyruvate carboxylase	Rattus norvegicus	189-209
1716636-1	1991	Site-directed mutagenesis studies have suggested that additional peptide information in the central cell-binding domain of fibronectin besides the minimal Arg-Gly-Asp (RGD) sequence is required for its full adhesive activity.	Aspartic Acid	163-166	fibronectin 1	Homo sapiens	123-134
1716682-6	1991	A detailed structure-activity analysis of a series of urea-substituted tetrapeptides, represented by the general structure Boc-Trp-Lys(N epsilon-CO-NHR)-Asp-Phe-NH2, revealed that a number of substituted phenyl, naphthyl, and aliphatic urea residues in the lysine side chain yielded potent and selective CCK-A ligands.	Aspartic Acid	153-156	brother of CDO	Cavia porcellus	123-126
1874740-1	1991	Previous studies of adhesion mediated by the central cell-binding domain of fibronectin suggest that additional polypeptide information besides the Arg-Gly-Asp sequence is required for full activity.	Aspartic Acid	156-159	fibronectin 1	Homo sapiens	76-87
1651333-5	1991	The sequence of GP Ib alpha between residues 269-287 has a strong net negative charge due to the presence of 10 glutamic or aspartic acid residues; 5 of these are contained in the sequence of a synthetic peptide (residues 251-279) previously shown to inhibit vWF-platelet interaction.	Aspartic Acid	124-137	glycoprotein Ib platelet subunit alpha	Homo sapiens	16-27
1911846-7	1991	These results indicate that the precise positioning of the negatively charged carboxylate in the geometry of reaction center is essential for the rate enhancement in the catalytic action of lysozyme, and suggest that Asp-53 of human lysozyme participates in the catalytic action not simply in an electrostatical manner but partly in a nucleophilical manner.	Aspartic Acid	217-220	lysozyme	Homo sapiens	190-198
1911846-7	1991	These results indicate that the precise positioning of the negatively charged carboxylate in the geometry of reaction center is essential for the rate enhancement in the catalytic action of lysozyme, and suggest that Asp-53 of human lysozyme participates in the catalytic action not simply in an electrostatical manner but partly in a nucleophilical manner.	Aspartic Acid	217-220	lysozyme	Homo sapiens	233-241
1911846-1	1991	The role of aspartic acid 53 of human lysozyme (peptidoglycan N-acetylmuramoylhydrolase, EC 3.2.1.17) has been investigated by a site-directed mutagenesis.	Aspartic Acid	12-25	lysozyme	Homo sapiens	38-46
1907272-1	1991	The Arg-Gly-Asp (RGD)-binding domain of GPIIb-IIIa has been localized in a fragment of the GPIIIa subunit that includes the sequence between amino acids 109 and 171.	Aspartic Acid	12-15	integrin subunit beta 3	Homo sapiens	91-97
1861080-10	1991	Sequencing of the C3b-like fragment purified by reverse phase chromatography indicates that initial cleavage of C3 by purified cathepsin G occurs at two positions in the amino-terminal part of the alpha-chain, at a Arg-Ser bond located between residues 748 and 749 and at a Leu-Asp bond between residues 751 and 752.	Aspartic Acid	278-281	cathepsin G	Homo sapiens	127-138
1907272-0	1991	A highly conserved sequence of the Arg-Gly-Asp-binding domain of the integrin beta 3 subunit is sensitive to stimulation.	Aspartic Acid	43-46	integrin subunit beta 3	Homo sapiens	69-84
1907272-1	1991	The Arg-Gly-Asp (RGD)-binding domain of GPIIb-IIIa has been localized in a fragment of the GPIIIa subunit that includes the sequence between amino acids 109 and 171.	Aspartic Acid	12-15	integrin subunit alpha 2b	Homo sapiens	40-45
1783488-0	1991	Aminopeptidase resistant Arg-Gly-Asp analogs are stable in plasma and inhibit platelet aggregation.	Aspartic Acid	33-36	carboxypeptidase Q	Homo sapiens	0-14
1918521-1	1991	The strong calcium-binding site of alpha-lactalbumin comprises the carboxylate side chains of aspartic acid 82, 87, and 88 and the carbonyl oxygens of residues 79 and 84.	Aspartic Acid	94-107	lactalbumin alpha	Bos taurus	35-52
1688068-5	1991	Allelic distributions have been investigated in view of a) possible inter-ethnic differences; b) identification of risk and protective alleles and c) the prevalence of DQB1 aspartate 57 negative and DQA1 arginine 52 positive alleles in control and diabetic groups.	Aspartic Acid	173-182	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	168-172
1688068-8	1991	A majority of patients were homozygote for DQB1 Asp 57 negativity: 83% (French) and 63% (Algerian).	Aspartic Acid	48-51	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	43-47
1681984-3	1991	Selective activation of the low-threshold (A beta) primary afferent fibers resulted in a two-fold increase in the rate of basal outflow of Asp and a smaller increase in the outflow of Glu from the rat spinal dorsal horn slices into the superfusing medium.	Aspartic Acid	139-142	amyloid beta precursor protein	Rattus norvegicus	43-49
1770310-3	1991	ApoA-I Yame was found to have aspartic acid (GAC) substituted by tyrosine (TAC) at residue 13.	Aspartic Acid	30-43	apolipoprotein A1	Homo sapiens	0-6
1713692-6	1991	Mutants of CD4 expressing amino acids with distinct physicochemical properties at positions Arg-54, Ala-55, Asp-56, and Ser-57 in V1, the first extracellular immunoglobulin-like domain, have been generated and studied qualitatively and quantitatively for interaction with HLA class II antigens, for membrane expression, for the integrity of CD4 epitopes recognized by a panel of monoclonal antibodies, and for gp120 binding.	Aspartic Acid	108-111	CD4 molecule	Homo sapiens	11-14
1856189-8	1991	Based on the sequence similarity and the mechanism of CBE binding, Asp-518 is predicted to be the essential carboxylate in the active site of lysosomal alpha-glucosidase.	Aspartic Acid	67-70	alpha glucosidase	Homo sapiens	142-169
1833851-7	1991	Three different types of post-translationally modified amino acid residues are found in protein S, 11 gamma-carboxy glutamic acid residues in the vitamin K-dependent domain, a beta-hydroxylated aspartic acid in the first EGF-like domain and a beta-hydroxylated asparagine in each of the other three EGF-like domains.	Aspartic Acid	194-207	epidermal growth factor	Homo sapiens	221-224
1886613-1	1991	Dihydrodipicolinate synthase (DHPS; EC 4.2.1.52) is the first committed enzyme in the lysine branch of the aspartate-derived amino acid biosynthesis pathway and is common to bacteria and plants.	Aspartic Acid	107-116	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	0-28
1886613-1	1991	Dihydrodipicolinate synthase (DHPS; EC 4.2.1.52) is the first committed enzyme in the lysine branch of the aspartate-derived amino acid biosynthesis pathway and is common to bacteria and plants.	Aspartic Acid	107-116	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	30-34
1659747-9	1991	In the third experiment the RGDS peptide (ARG-GLY-ASP-SER), a blocker of GPIIb/IIIa platelet receptor dose dependently inhibited platelet aggregation by 93 +/- 17%.	Aspartic Acid	50-53	ral guanine nucleotide dissociation stimulator	Homo sapiens	28-32
1659747-9	1991	In the third experiment the RGDS peptide (ARG-GLY-ASP-SER), a blocker of GPIIb/IIIa platelet receptor dose dependently inhibited platelet aggregation by 93 +/- 17%.	Aspartic Acid	50-53	integrin subunit alpha 2b	Homo sapiens	73-78
1856212-9	1991	These residues are Thr-78 and Met-80 in human GM-CSF and Asp-92, Thr-98, and Asp-102 in mouse GM-CSF.	Aspartic Acid	57-60	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	94-100
1856212-9	1991	These residues are Thr-78 and Met-80 in human GM-CSF and Asp-92, Thr-98, and Asp-102 in mouse GM-CSF.	Aspartic Acid	77-80	colony stimulating factor 2	Homo sapiens	46-52
1856212-9	1991	These residues are Thr-78 and Met-80 in human GM-CSF and Asp-92, Thr-98, and Asp-102 in mouse GM-CSF.	Aspartic Acid	77-80	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	94-100
2071611-12	1991	This deletion codes for amino acids Asn-319 and Asp-320 in the normal fibrinogen gamma-chain.	Aspartic Acid	48-51	fibrinogen gamma chain	Homo sapiens	70-92
2071611-13	1991	The data indicate that Asn-319 and Asp-320 are crucial for maintaining the integrity of the carboxyl-terminal polymerization sites, the protective effect of Ca2+ ions on plasmin degradation of the carboxyl terminus of the gamma-chain, and the calcium binding domain at the carboxyl terminus of fibrinogen.	Aspartic Acid	35-38	fibrinogen beta chain	Homo sapiens	294-304
1681984-4	1991	The activation of both the low (A beta)- and the high-threshold (A delta + C) primary afferents elicited also a significant increase in the outflow of Asp and Glu relative to control.	Aspartic Acid	151-154	amyloid beta precursor protein	Rattus norvegicus	32-38
1751226-4	1991	Furthermore, incorporation of the well known cell adhesive ligand Arg-Gly-Asp-Ser (RGDS) peptidyl moiety into the above co-polymer resulted, on UV light irradiation, in a three-dimensional hydrophilic gel matrix containing cell adhesive ligands.	Aspartic Acid	74-77	ral guanine nucleotide dissociation stimulator	Homo sapiens	83-87
2068075-7	1991	Site-directed mutation of the His-74 residue in HLA-A2 to the Asp-74 (HLA-A3, -Aw68, -Aw69, -B7) residue generates a mutant that provides C1R cell line transfectants an NK-resistant phenotype.	Aspartic Acid	62-65	complement C1r	Homo sapiens	138-141
1854332-2	1991	Aspartate-211 of yeast hexokinase has been implicated as a catalytic residue from crystallographic data.	Aspartic Acid	0-9	hexokinase	Saccharomyces cerevisiae S288C	23-33
2053288-6	1991	One of these domains, containing an Asp-Asp motif found in many RNA polymerases, also shares amino acid sequence homology with the PB1 polymerase component of influenza type A.	Aspartic Acid	36-39	polybromo 1	Homo sapiens	131-134
1659487-6	1991	The second class of compound is the closely related aspartate analogue 1-amino-1,2-cyclopentane dicarboxylic acid (1,2-ACPD).	Aspartic Acid	52-61	homer scaffold protein 2	Homo sapiens	119-123
1829526-3	1991	Its binding to FN was inhibited by anti-FN antibody or a mixture of synthetic peptides corresponding to two different sites of FN, termed the V10 sequence and the RGDS (Arg-Gly-Asp-Ser) sequence, which interact, respectively, with the VLA-4 and VLA-5 FN receptors expressed on T-lineage cells.	Aspartic Acid	177-180	ral guanine nucleotide dissociation stimulator	Mus musculus	163-167
1675710-3	1991	The replacement of glycine with an aspartic acid residue disrupts the fifth Gly-Xaa-Yaa repeat in the collagen-like domain of each 32 kD MBP peptide chain and probably prevents the formation of the normal triple helix.	Aspartic Acid	35-48	myelin basic protein	Homo sapiens	137-140
2053288-6	1991	One of these domains, containing an Asp-Asp motif found in many RNA polymerases, also shares amino acid sequence homology with the PB1 polymerase component of influenza type A.	Aspartic Acid	40-43	polybromo 1	Homo sapiens	131-134
2062369-13	1991	Unlike the other lipases and serine proteases, the catalytic triad of GCL is Ser-His-Glu, with glutamic acid replacing the usual aspartate.	Aspartic Acid	129-138	germ cell-less 2, spermatogenesis associated	Homo sapiens	70-73
2035536-0	1991	A single base mutation in type I procollagen (COL1A1) that converts glycine alpha 1-541 to aspartate in a lethal variant of osteogenesis imperfecta: detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR.	Aspartic Acid	91-100	collagen type I alpha 2 chain	Homo sapiens	26-44
1913146-1	1991	Reductions in glutamate and aspartate contents, together with increased contents of taurine, have been observed in the autopsied brains and spinal cords of patients who have died with amyotrophic lateral sclerosis (ALS).	Aspartic Acid	28-37	superoxide dismutase 1	Homo sapiens	215-218
1645728-7	1991	Furthermore, the -129/-115-bp sequence of the bovine cytochrome P450C21 gene corresponding to the human -126/-113-bp sequence is demonstrated to be functionally conserved with respect to both cAMP-dependent enhancement of transcription and ASP binding.	Aspartic Acid	240-243	steroid 21-hydroxylase	Bos taurus	53-71
2035536-0	1991	A single base mutation in type I procollagen (COL1A1) that converts glycine alpha 1-541 to aspartate in a lethal variant of osteogenesis imperfecta: detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR.	Aspartic Acid	91-100	collagen type I alpha 1 chain	Homo sapiens	46-52
2035536-5	1991	Subsequent amplification of the cDNA by the PCR and nucleotide sequencing revealed a single-base mutation that substituted an aspartate codon for glycine at position alpha 1-541 in the COL1A1 gene.	Aspartic Acid	126-135	collagen type I alpha 1 chain	Homo sapiens	185-191
1898002-0	1991	Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase.	Aspartic Acid	8-17	quinoid dihydropteridine reductase	Rattus norvegicus	82-108
1649766-2	1991	Like aspartate, APB/Kyn blocks photoreceptor synaptic transmission, as monitored by the b- and d-waves of the electroretinogram, by the proximal negative response and M-wave of the proximal retina, and by the light-evoked increase in extracellular K+ concentration in the inner plexiform layer.	Aspartic Acid	5-14	arginyl aminopeptidase	Homo sapiens	16-19
1673992-13	1991	Additional adhesion assays performed in the presence of a pentapeptide containing the amino acid sequence arg-gly-asp (RGD), which is part of one of the cell-binding domains of FN, demonstrated that the RGD-containing peptide almost totally blocked the phorbol ester-induced adhesion of U937 cells to FN.	Aspartic Acid	114-117	fibronectin 1	Homo sapiens	177-179
1676704-4	1991	In addition, the postulated risk DQ beta Asp 57-negative and DQ alpha Arg 52 positive is absent in six patients.	Aspartic Acid	41-44	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	33-40
1674522-8	1991	Inasmuch as the 140-kDa fragment of TSP contains an Arg-Gly-Asp sequence similar to the cell recognition site of FN and VN, we determined whether RGDS peptides would inhibit PMN adhesion.	Aspartic Acid	60-63	thrombospondin 1	Homo sapiens	36-39
1673992-13	1991	Additional adhesion assays performed in the presence of a pentapeptide containing the amino acid sequence arg-gly-asp (RGD), which is part of one of the cell-binding domains of FN, demonstrated that the RGD-containing peptide almost totally blocked the phorbol ester-induced adhesion of U937 cells to FN.	Aspartic Acid	114-117	fibronectin 1	Homo sapiens	301-303
1768290-2	1991	Groups of the conformations were selected for the three analogues, allowing a spatial matching of Trp, Asp and Phe residues responsible for the gastrin receptor binding.	Aspartic Acid	103-106	cholecystokinin B receptor	Homo sapiens	144-160
19215469-1	1991	Abstract Aspartate and glutamate represent a major class of excitatory amino-acid neurotransmitters in the vertebrate brain, and stimulation of gtutaminergic receptors by the specific agonist N-methyl-D, L-aspartate (NMDA) induces luteinizing hormone-releasing hormone (LHRH) and LH secretion.	Aspartic Acid	9-18	gonadotropin releasing hormone 1	Homo sapiens	231-268
19215469-1	1991	Abstract Aspartate and glutamate represent a major class of excitatory amino-acid neurotransmitters in the vertebrate brain, and stimulation of gtutaminergic receptors by the specific agonist N-methyl-D, L-aspartate (NMDA) induces luteinizing hormone-releasing hormone (LHRH) and LH secretion.	Aspartic Acid	9-18	gonadotropin releasing hormone 1	Homo sapiens	270-274
1828889-7	1991	Placing the Ca2+ ATP of actin on the ATPase fragment structure suggests Asp-206 (corresponding to His-161 of actin) as a candidate proton acceptor for the ATPase reaction.	Aspartic Acid	72-75	actin epsilon 1	Bos taurus	24-29
1828889-7	1991	Placing the Ca2+ ATP of actin on the ATPase fragment structure suggests Asp-206 (corresponding to His-161 of actin) as a candidate proton acceptor for the ATPase reaction.	Aspartic Acid	72-75	actin epsilon 1	Bos taurus	109-114
2049386-9	1991	Candidate residues are Glu-15 or Asp-20, close to His-16 on the N-terminal helix of IL-2.	Aspartic Acid	33-36	interleukin 2	Homo sapiens	84-88
2036395-0	1991	Aspartic acid residues at positions 190 and 192 of rat DNA polymerase beta are involved in primer binding.	Aspartic Acid	0-13	DNA polymerase beta	Rattus norvegicus	55-74
2036395-1	1991	The sequence Gly-Asp-Met-Asp, spanning positions 189-192 of rat DNA polymerase beta, is similar to the sequence motif Gly-Asp-Thr-Asp that is highly conserved in a number of replicative DNA polymerases from eukaryotic cells, viruses, and phages.	Aspartic Acid	17-20	DNA polymerase beta	Rattus norvegicus	64-83
2036395-7	1991	Since neither DE190 nor DE192 had any significant alteration in secondary structure, our results suggest that both Asp-190 and Asp-192 are located in the active site and are involved in the interaction of DNA polymerase beta with primer.	Aspartic Acid	115-118	DNA polymerase beta	Rattus norvegicus	205-224
2036395-7	1991	Since neither DE190 nor DE192 had any significant alteration in secondary structure, our results suggest that both Asp-190 and Asp-192 are located in the active site and are involved in the interaction of DNA polymerase beta with primer.	Aspartic Acid	127-130	DNA polymerase beta	Rattus norvegicus	205-224
1903394-1	1991	The assembly of fibronectin into disulfide cross-linked extracellular matrices requires the interaction of mesenchymal cells with two distinct sites on fibronectin, the Arg-Gly-Asp cell adhesive site and an amino-terminal site contained within the first five type I homologous repeats (Quade, B. J., and McDonald, J.	Aspartic Acid	177-180	fibronectin 1	Homo sapiens	16-27
1903394-1	1991	The assembly of fibronectin into disulfide cross-linked extracellular matrices requires the interaction of mesenchymal cells with two distinct sites on fibronectin, the Arg-Gly-Asp cell adhesive site and an amino-terminal site contained within the first five type I homologous repeats (Quade, B. J., and McDonald, J.	Aspartic Acid	177-180	fibronectin 1	Homo sapiens	152-163
1708943-0	1991	Novel effect of cyclicization of the Arg-Gly-Asp-containing peptide on vitronectin binding to platelets.	Aspartic Acid	45-48	vitronectin	Homo sapiens	71-82
1848852-8	1991	Modification with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide at Glu-74, Asp-79, and Asp-86 inhibited the interaction with both adrenodoxin reductase and cytochrome P-450scc (Lambeth, D. J., Geren, L. M., and Millett, F. (1984) J. Biol.	Aspartic Acid	75-78	ferredoxin reductase	Bos taurus	130-151
1713869-4	1991	The insulin analogue B10 Asp tended to be more potent than insulin in displacing 125I-insulin, B28 Asp was equipotent, B9 Asp/B27 Glu was approximately 100 times less potent and insulin-like growth factor-I more than 1000 times less potent than insulin.	Aspartic Acid	25-28	insulin-like growth factor 1	Rattus norvegicus	178-206
2023899-8	1991	Protein sequence analysis revealed that one of the PIF peptides was Trp-Cys-Leu-Glu-Ser-Ser-Gln-Cys-Gln-Asp-Leu-Ser-Thr-Glu-Ser-Asn-Leu-Leu- Ala-Cys - Ile-Arg-Ala-Cys-Lys-Pro, identical to residues 27-52 of the N-terminal region of the proopiomelanocortin (POMC) precursor (corresponding to amino acids 1-26 of the 16-kDa fragment).	Aspartic Acid	104-107	proopiomelanocortin	Rattus norvegicus	236-255
2023899-8	1991	Protein sequence analysis revealed that one of the PIF peptides was Trp-Cys-Leu-Glu-Ser-Ser-Gln-Cys-Gln-Asp-Leu-Ser-Thr-Glu-Ser-Asn-Leu-Leu- Ala-Cys - Ile-Arg-Ala-Cys-Lys-Pro, identical to residues 27-52 of the N-terminal region of the proopiomelanocortin (POMC) precursor (corresponding to amino acids 1-26 of the 16-kDa fragment).	Aspartic Acid	104-107	proopiomelanocortin	Rattus norvegicus	257-261
1672884-0	1991	Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area.	Aspartic Acid	41-50	carbonic anhydrase 1	Homo sapiens	90-93
1850017-5	1991	However, replacement of the alanine residue with aspartic acid (4003A.D) caused a dramatic reduction (about 40 to 60%) in myristoylation levels of the VP4 precursors (P1 and VP0).	Aspartic Acid	49-62	crystallin gamma F, pseudogene	Homo sapiens	167-177
1685266-0	1991	Aspartic acid at position 57 of the HLA-DQ beta chain in insulin-dependent diabetes mellitus: an association with one DRw9-DQw9 subtype in the Chinese population.	Aspartic Acid	0-13	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	36-47
1850414-1	1991	The Tar-EnvZ hybrid molecule (Taz1) is an inner membrane transducer that activates OmpR, a transcriptional activator for porin gene expression (ompC), in response to an aspartic acid signal.	Aspartic Acid	169-182	zinc finger and BTB domain containing 18	Homo sapiens	30-34
1850414-1	1991	The Tar-EnvZ hybrid molecule (Taz1) is an inner membrane transducer that activates OmpR, a transcriptional activator for porin gene expression (ompC), in response to an aspartic acid signal.	Aspartic Acid	169-182	voltage dependent anion channel 1	Homo sapiens	121-126
1901803-1	1991	Chemical modification studies suggest that two residues of bovine pancreatic ribonuclease A (RNase A), Lys-41 and Asp-121, are important for catalysis.	Aspartic Acid	114-117	ribonuclease pancreatic	Bos taurus	77-91
1901803-1	1991	Chemical modification studies suggest that two residues of bovine pancreatic ribonuclease A (RNase A), Lys-41 and Asp-121, are important for catalysis.	Aspartic Acid	114-117	ribonuclease pancreatic	Bos taurus	93-100
1848852-8	1991	Modification with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide at Glu-74, Asp-79, and Asp-86 inhibited the interaction with both adrenodoxin reductase and cytochrome P-450scc (Lambeth, D. J., Geren, L. M., and Millett, F. (1984) J. Biol.	Aspartic Acid	75-78	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	156-175
1848852-8	1991	Modification with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide at Glu-74, Asp-79, and Asp-86 inhibited the interaction with both adrenodoxin reductase and cytochrome P-450scc (Lambeth, D. J., Geren, L. M., and Millett, F. (1984) J. Biol.	Aspartic Acid	87-90	ferredoxin reductase	Bos taurus	130-151
1848852-8	1991	Modification with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide at Glu-74, Asp-79, and Asp-86 inhibited the interaction with both adrenodoxin reductase and cytochrome P-450scc (Lambeth, D. J., Geren, L. M., and Millett, F. (1984) J. Biol.	Aspartic Acid	87-90	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	156-175
2009258-2	1991	Since the axial C-4 proton is removed by Asp-38 from above the substrate, a determination of the complete stereochemistry of this rapid, concerted enolization requires information on the direction of approach of Tyr-14 to the enzyme-bound steroid.	Aspartic Acid	41-44	complement C4A (Rodgers blood group)	Homo sapiens	16-19
1672477-0	1991	Sex- and dose-dependent effects of neonatally administered aspartate on the ultradian patterns of circulating growth hormone regulating hexobarbital metabolism and action.	Aspartic Acid	59-68	gonadotropin releasing hormone receptor	Rattus norvegicus	110-124
1679147-5	1991	Stable levels of aspartate and glutamate were found above the stratum radiatum of CA1.	Aspartic Acid	17-26	carbonic anhydrase 1	Homo sapiens	82-85
1870574-5	1991	The highest mode of point mutation of K-ras oncogene was GGT to GAT coded aspartic acid.	Aspartic Acid	74-87	KRAS proto-oncogene, GTPase	Homo sapiens	38-43
1850997-2	1991	Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin.	Aspartic Acid	154-157	vimentin	Homo sapiens	238-246
1850997-2	1991	Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin.	Aspartic Acid	173-176	vimentin	Homo sapiens	238-246
2010048-7	1991	The unusual DQB1 allele on this DR2 haplotype encodes Asp at position 57, indicating that it is the allele DQB1*0602 and not simply the presence of this residue that is responsible for the protective effect.	Aspartic Acid	54-57	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	12-16
2010048-7	1991	The unusual DQB1 allele on this DR2 haplotype encodes Asp at position 57, indicating that it is the allele DQB1*0602 and not simply the presence of this residue that is responsible for the protective effect.	Aspartic Acid	54-57	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	107-111
1849145-7	1991	When compared with the predicted primary structure of human gelsolin a single amino acid substitution is present in amyloid: at position 15 of the amyloid proteins an asparagine is found instead of an aspartic acid residue at the corresponding position (187) in gelsolin.	Aspartic Acid	201-214	gelsolin	Homo sapiens	60-68
2002350-1	1991	The sulphated octapeptide of cholecystokinin (CCK-8S) was found to cause a dose-dependent increase in the basal release of aspartate, glycine, and gamma-aminobutyric acid from the striatum and the ventromedial nucleus of the hypothalamus (VMH).	Aspartic Acid	123-132	cholecystokinin	Rattus norvegicus	29-44
1826365-7	1991	These results with IL-1ra K145D demonstrate the importance of the region surrounding the corresponding Asp-145 residue in IL-1 beta for triggering the biological response to IL-1.	Aspartic Acid	103-106	interleukin 1 receptor antagonist	Mus musculus	19-25
1826365-7	1991	These results with IL-1ra K145D demonstrate the importance of the region surrounding the corresponding Asp-145 residue in IL-1 beta for triggering the biological response to IL-1.	Aspartic Acid	103-106	interleukin 1 beta	Mus musculus	122-131
1672314-5	1991	Structural analyses demonstrate that cleavage of 32P-labeled P-glycoprotein at Asp-Pro linkages with formic acid results in the formation of a major phosphorylated peptide of 35 kDa and a minor peptide of 42 kDa.	Aspartic Acid	79-82	ATP binding cassette subfamily B member 1	Homo sapiens	61-75
1672854-2	1991	Four mutants of the human cap binding protein (hCBP), in which Trp-102, Glu-103, Asp-104 or Glu-105 was changed to the aliphatic Leu or Ala, were prepared, and their cap binding abilities were examined.	Aspartic Acid	81-84	CREB binding protein	Homo sapiens	47-51
2001376-8	1991	Features of this sequence which showed the greatest similarity to mammalian osteopontin included a region in which seven of nine consecutive residues are aspartic acid, a recognition sequence for integrin-mediated cell binding (-Arg-Gly-Asp), and four possible recognition sequences for phosphorylation by casein kinase II.	Aspartic Acid	154-167	secreted phosphoprotein 1	Homo sapiens	76-87
1999399-7	1991	Substitution of the histidine in position 435 with glutamine, arginine, alanine, serine, or aspartic acid abolished the ability of cholesterol esterase to hydrolyze p-nitrophenyl butyrate and cholesterol [14C]oleate.	Aspartic Acid	92-105	carboxyl ester lipase	Rattus norvegicus	131-151
1999429-9	1991	Studies with Asp-179 site-directed mutants of preprominiPLAP showed the same specificity for amino acids with a monosubstituted beta carbon at the cleavage/attachment site that were found previously with wild type PLAP.	Aspartic Acid	13-16	alkaline phosphatase, placental	Homo sapiens	56-60
2001376-8	1991	Features of this sequence which showed the greatest similarity to mammalian osteopontin included a region in which seven of nine consecutive residues are aspartic acid, a recognition sequence for integrin-mediated cell binding (-Arg-Gly-Asp), and four possible recognition sequences for phosphorylation by casein kinase II.	Aspartic Acid	237-240	secreted phosphoprotein 1	Homo sapiens	76-87
2002506-0	1991	Proton nuclear magnetic resonance study of the B9(Asp) mutant of human insulin.	Aspartic Acid	50-53	insulin	Homo sapiens	71-78
1993839-6	1991	For DR2 and DR3 the shortest peptide was residues 6-15, an additional serine (residue 5) was required for DR1 and DR7 and an aspartic acid (residue 4) for DR4, DR5, and DR6.	Aspartic Acid	125-138	major histocompatibility complex, class II, DR beta 4	Homo sapiens	155-158
1880128-7	1991	The delay period increased with the decrease in substrate concentration, and was shortened by using the [Asp 101 or Trp 62]-modified lysozyme instead of the native lysozyme.	Aspartic Acid	105-108	lysozyme	Homo sapiens	133-141
1825316-2	1991	125I-labeled fibronectin was inhibited from binding to the fungus by unlabeled human plasma fibronectin and by Arg-Gly-Asp (RGD), Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), and Gly-Arg-Gly-Asp-Thr-Pro (GRGDTP), but binding was not inhibited by Gly-Arg-Gly-Asp-Ser-Pro.	Aspartic Acid	119-122	fibronectin 1	Homo sapiens	13-24
1999271-2	1991	A peptide corresponding to the COOH-terminal domain of the GLUT1 glucose transporter (Thr-Pro-Glu-Glu-Leu-Phe-His-Pro-Leu-Gly-Ala-Asp-Ser-Gln-Val) was synthesized and conjugated to keyhole limpet hemocyanin through the NH2-terminal of the peptide.	Aspartic Acid	130-133	solute carrier family 2 member 1	Homo sapiens	59-64
1825316-2	1991	125I-labeled fibronectin was inhibited from binding to the fungus by unlabeled human plasma fibronectin and by Arg-Gly-Asp (RGD), Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), and Gly-Arg-Gly-Asp-Thr-Pro (GRGDTP), but binding was not inhibited by Gly-Arg-Gly-Asp-Ser-Pro.	Aspartic Acid	180-183	fibronectin 1	Homo sapiens	13-24
1825316-2	1991	125I-labeled fibronectin was inhibited from binding to the fungus by unlabeled human plasma fibronectin and by Arg-Gly-Asp (RGD), Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), and Gly-Arg-Gly-Asp-Thr-Pro (GRGDTP), but binding was not inhibited by Gly-Arg-Gly-Asp-Ser-Pro.	Aspartic Acid	180-183	fibronectin 1	Homo sapiens	13-24
1993839-6	1991	For DR2 and DR3 the shortest peptide was residues 6-15, an additional serine (residue 5) was required for DR1 and DR7 and an aspartic acid (residue 4) for DR4, DR5, and DR6.	Aspartic Acid	125-138	TNF receptor superfamily member 10b	Homo sapiens	160-163
1993839-6	1991	For DR2 and DR3 the shortest peptide was residues 6-15, an additional serine (residue 5) was required for DR1 and DR7 and an aspartic acid (residue 4) for DR4, DR5, and DR6.	Aspartic Acid	125-138	TNF receptor superfamily member 21	Homo sapiens	169-172
1871764-0	1991	The HLA-DQ beta non-Asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune Addison"s disease.	Aspartic Acid	20-23	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-15
1871764-5	1991	We thus conclude that particular polymorphic alleles corresponding to non-charged amino acids at position 57 of the HLA-DQ beta-chain [non-Asp-57 alleles] are associated with IDDM also in Addison"s patients.	Aspartic Acid	139-142	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	116-119
2041376-0	1991	Aspartic acid at position 57 of the HLA-DQ beta chain is protective against future development of insulin-dependent (type 1) diabetes mellitus.	Aspartic Acid	0-13	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	36-39
1998686-8	1991	Potential catalytic roles are assigned to the conserved His 214, Cys 262, Asp 295, and Asp 296 residues of mammalian adenosine deaminases and the corresponding conserved amino acid residues in bacterial adenosine deaminase and the eukaryotic AMP deaminases.	Aspartic Acid	74-77	adenosine deaminase	Homo sapiens	117-136
1998686-8	1991	Potential catalytic roles are assigned to the conserved His 214, Cys 262, Asp 295, and Asp 296 residues of mammalian adenosine deaminases and the corresponding conserved amino acid residues in bacterial adenosine deaminase and the eukaryotic AMP deaminases.	Aspartic Acid	87-90	adenosine deaminase	Homo sapiens	117-136
2041376-9	1991	Conversely, HLA haplotypes positive for aspartic acid seem to confer resistance to the disease.	Aspartic Acid	40-53	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	12-15
1846556-5	1991	Third-position substitutions have less of an effect on NAT activity with glycine, aspartic acid, glutamic acid, and tryptophan being most inhibiting (with N-terminal Ser-Tyr).	Aspartic Acid	82-95	N-acetyltransferase 1	Rattus norvegicus	55-58
1750929-10	1991	The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin.	Aspartic Acid	65-68	chorionic somatomammotropin hormone like 1	Homo sapiens	35-38
1989985-4	1991	Isolated human prostatic acid phosphatase was found to have multiple carboxyl-terminal ends, terminating in Thr, Glu, and Asp, corresponding to residues 349-351 of the 354-residue protein that is predicted from the cDNA sequence after removal of a leader peptide.	Aspartic Acid	122-125	acid phosphatase 3	Homo sapiens	15-41
2013056-9	1991	Aspartic acid 70, present in the anionic site of human BChE, is also conserved in rabbit BChE.	Aspartic Acid	0-13	butyrylcholinesterase	Homo sapiens	55-59
2013056-9	1991	Aspartic acid 70, present in the anionic site of human BChE, is also conserved in rabbit BChE.	Aspartic Acid	0-13	cholinesterase	Oryctolagus cuniculus	89-93
2045450-3	1991	Microsequence analysis showed that both proteins have the same N-terminal sequence Pro-Ala-Leu-Pro-Glu-Asp-Gly-Gly-Ser-Gly-Ala-Phe..., which is identical with that of (1-146) bFGF extracted from human brain.	Aspartic Acid	103-106	fibroblast growth factor 2	Homo sapiens	175-179
1847139-7	1991	Partial sequencing of the cross-linked, radioactive peptides has identified a site of the pump located C terminally to the phosphoenzyme-forming aspartic acid, spanning residues 537-544 of the hPMCA4 isoform of the enzyme.	Aspartic Acid	145-158	ATPase plasma membrane Ca2+ transporting 4	Homo sapiens	193-199
1864844-9	1991	In conclusion, triflavin specifically binds to fibrinogen receptor associated with GP IIb/IIIa complex and its binding site is located at or near GP IIb/IIIa complex, overlapping with those of 7E3 and another Arg-Gly-Asp-containing polypeptide, rhodostomin.	Aspartic Acid	217-220	fibrinogen beta chain	Homo sapiens	47-57
1988965-7	1991	The data indicate that the murine BP-1/6C3 antigen is active APA, an enzyme that catalyzes specifically the removal of unsubstituted, N-terminal glutamic acid and aspartic acid residues from peptides.	Aspartic Acid	163-176	glutamyl aminopeptidase	Mus musculus	34-42
1988934-4	1991	Within this region 58%, 65%, and 50% of the amino acids of PC3 are identical to those of the aligned PC2, furin, and kex2 sequences, respectively, and the catalytically important Asp, His, and Ser residues are all conserved.	Aspartic Acid	179-182	proprotein convertase subtilisin/kexin type 1	Mus musculus	59-62
1703153-11	1991	The combination of heparin and Arg-Gly-Asp-Ser inhibited G361 attachment to TSP.	Aspartic Acid	39-42	thrombospondin 1	Homo sapiens	76-79
1988965-7	1991	The data indicate that the murine BP-1/6C3 antigen is active APA, an enzyme that catalyzes specifically the removal of unsubstituted, N-terminal glutamic acid and aspartic acid residues from peptides.	Aspartic Acid	163-176	glutamyl aminopeptidase	Mus musculus	61-64
1985927-9	1991	Purified Q31 granzyme B had a preference for substrates with Glu or Asp as the residue amino-terminal to the scissile bond; little or no activity was noted with oligopeptide substrates for trypsin-like, chymotrypsin-like, and elastase-like proteases.	Aspartic Acid	68-71	granzyme B	Homo sapiens	13-23
1846292-9	1991	Both IGF I receptor dimers and tetramers exhibit similar kinase activities using the synthetic substrate Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, indicating that the failure to detect autophosphorylation of the IGF I receptor dimers does not result from inactivation of the kinase by DTT treatment.	Aspartic Acid	125-128	insulin like growth factor 1 receptor	Homo sapiens	5-19
1824079-2	1991	In the case of AST, the compound decreased absorption and CD maxima at 360 nm, which represents the active form of the enzyme, but it did not seem to prevent formation of the pyridoxamine form of the enzyme, produced in the presence of L-aspartate.	Aspartic Acid	236-247	solute carrier family 17 member 5	Homo sapiens	15-18
1987790-12	1991	Aspartic acid caused the strongest stimulation of GH secretion, exceeding that induced by arginine.	Aspartic Acid	0-13	somatotropin	Ovis aries	50-52
2049934-1	1991	Comparison of amino acid sequences of the alpha-chain fragment of human C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 in which the aspartic acid-histidine substitution at position 1106 may be related to the amide and ester bond forming properties of these molecules.	Aspartic Acid	158-171	complement C4A (Rodgers blood group)	Homo sapiens	72-79
2049934-1	1991	Comparison of amino acid sequences of the alpha-chain fragment of human C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 in which the aspartic acid-histidine substitution at position 1106 may be related to the amide and ester bond forming properties of these molecules.	Aspartic Acid	158-171	complement C4B (Chido blood group)	Homo sapiens	100-103
2010690-7	1991	In comparison with other current methods, PCR using ASP is suggested as a rapid and simple noninvasive technique for determining population apoE allelic distribution.	Aspartic Acid	52-55	apolipoprotein E	Homo sapiens	140-144
1988465-0	1991	An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion.	Aspartic Acid	11-14	coagulation factor II, thrombin	Homo sapiens	31-39
2125495-1	1990	Site-specific mutagenesis has been employed to alter the cDNA of human protein C (PC), such that the gamma-carboxyglutamic acid (gamma) pair at positions 6 and 7 of the recombinant (r) protein would be changed to aspartic acid residues.	Aspartic Acid	213-226	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	71-80
1684835-12	1991	In CA3 the lowest values of glutamate, aspartate, taurine and somatostatin were also found.	Aspartic Acid	39-48	carbonic anhydrase 3	Rattus norvegicus	3-6
1946346-16	1991	In analogy with the crystal structure of skeletal troponin C it is hypothezed that in cardiac troponin C an interaction occurs between Gln-50 and Asp-88, which has a long-range effect on calcium binding.	Aspartic Acid	146-149	troponin C1, slow skeletal and cardiac type	Homo sapiens	86-104
2268358-1	1990	The substitution of aspartic acid for the naturally-occurring histidine residue in position B10 in human insulin results in an insulin analogue which displays an in vitro potency 4- to 5-fold greater than the parent compound.	Aspartic Acid	20-33	insulin	Homo sapiens	105-112
2268358-1	1990	The substitution of aspartic acid for the naturally-occurring histidine residue in position B10 in human insulin results in an insulin analogue which displays an in vitro potency 4- to 5-fold greater than the parent compound.	Aspartic Acid	20-33	insulin	Homo sapiens	127-134
1845883-2	1991	We examined the relationship between membrane localization and transforming activity of P68 by changing Val-168-Val-169 in its hydrophobic domain into Asp-168-Glu-169.	Aspartic Acid	151-154	annexin A6	Gallus gallus	88-91
1793483-5	1991	It leads to the substitution of glycine by aspartic acid in the resulting p21 protein, a consistent amino acid substitution found so far in all types of human cancer exhibiting a codon 13-mutated Ki-ras gene.	Aspartic Acid	43-56	H3 histone pseudogene 16	Homo sapiens	74-77
1793483-5	1991	It leads to the substitution of glycine by aspartic acid in the resulting p21 protein, a consistent amino acid substitution found so far in all types of human cancer exhibiting a codon 13-mutated Ki-ras gene.	Aspartic Acid	43-56	KRAS proto-oncogene, GTPase	Homo sapiens	196-202
1842094-2	1991	These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.	Aspartic Acid	122-137	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Homo sapiens	52-69
2259385-8	1990	This mutation leads to substitution of aspartic acid for glycine in one of the regions identified as a frequent target of point mutations in p53.	Aspartic Acid	39-52	tumor protein p53	Homo sapiens	141-144
2260635-10	1990	The results of these experiments show that attachment and spreading of bovine aortic endothelial and smooth muscle cells depend primarily on the presence of the Arg-Gly-Asp-Ser (RGDS) sequence in the recombinant fibronectin proteins.	Aspartic Acid	169-172	ral guanine nucleotide dissociation stimulator	Mus musculus	178-182
2260635-10	1990	The results of these experiments show that attachment and spreading of bovine aortic endothelial and smooth muscle cells depend primarily on the presence of the Arg-Gly-Asp-Ser (RGDS) sequence in the recombinant fibronectin proteins.	Aspartic Acid	169-172	fibronectin 1	Bos taurus	212-223
1963688-1	1990	Modification of glutamic and aspartic acid residues of tissue-type plasminogen activator (t-PA) with 1-ethyl-3(3-dimethyl-aminopropyl)-carbodiimide leads to a decrease in affinity for lysine and fibrin, to a decrease of plasminogen activation activity in the presence of a fibrin mimic, but leaves amidolytic activity and plasminogen activation without fibrin mimic unaffected.	Aspartic Acid	29-42	plasminogen activator, tissue type	Homo sapiens	55-88
2275561-8	1990	Titrations of mutants B13-Glu----Gln and B9-Ser----Asp show that the masked ionization probably originates from monomer-monomer interactions in the insulin dimer.	Aspartic Acid	51-54	insulin	Homo sapiens	148-155
2099335-3	1990	Aspartate and glutamate administration (100 mg/kg, ip) significantly reduced these elevated levels of AST, ALT, and gamma-GT.	Aspartic Acid	0-9	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	102-105
2099335-3	1990	Aspartate and glutamate administration (100 mg/kg, ip) significantly reduced these elevated levels of AST, ALT, and gamma-GT.	Aspartic Acid	0-9	gamma-glutamyltransferase 1	Rattus norvegicus	116-124
2243383-10	1990	This hypothesis was supported by cell-free translation of mutant L1R transcripts in which the penultimate glycine codon had been altered by site-directed mutagenesis to encode either an aspartic acid (pL1D1) or alanine (pL1A1) residue.	Aspartic Acid	186-199	IMV membrane protein	Vaccinia virus	65-68
1963688-1	1990	Modification of glutamic and aspartic acid residues of tissue-type plasminogen activator (t-PA) with 1-ethyl-3(3-dimethyl-aminopropyl)-carbodiimide leads to a decrease in affinity for lysine and fibrin, to a decrease of plasminogen activation activity in the presence of a fibrin mimic, but leaves amidolytic activity and plasminogen activation without fibrin mimic unaffected.	Aspartic Acid	29-42	plasminogen activator, tissue type	Homo sapiens	90-94
1963688-2	1990	Experiments with kringle-2 ligands and a deletion mutant of t-PA (K2P) suggests that glutamic or aspartic acid residues in K2 of t-PA are involved in stimulation of activity, lysine binding and fibrin binding.	Aspartic Acid	97-110	plasminogen activator, tissue type	Homo sapiens	60-64
1963688-2	1990	Experiments with kringle-2 ligands and a deletion mutant of t-PA (K2P) suggests that glutamic or aspartic acid residues in K2 of t-PA are involved in stimulation of activity, lysine binding and fibrin binding.	Aspartic Acid	97-110	plasminogen activator, tissue type	Homo sapiens	129-133
2257621-3	1990	Accordingly, we expressed in L cells mutant uvomorulin with a replacement of Asp to Lys or Ala.	Aspartic Acid	77-80	cadherin 1	Homo sapiens	44-54
2246265-7	1990	Among 11 Xaa-Ala-Ser analogues (Xaa = Ala, Asp, Gln, Glu, Ile, Leu, Lys, Met, Phe, Pro, and Ser), MAP cleaved only Met-Ala-Ser.	Aspartic Acid	43-46	methionine aminopeptidase	Saccharomyces cerevisiae S288C	98-101
1981672-0	1990	Relaxed specificity of endoproteinase Asp-N: this enzyme cleaves at peptide bonds N-terminal to glutamate as well as aspartate and cysteic acid residues.	Aspartic Acid	117-126	asporin	Homo sapiens	38-43
1704112-1	1990	Using whole cell recordings in combination with the concentration clamp technique it was shown that even enzymatically isolated hippocampal CA1 and CA3 neurons exhibit N-methyl-D-aspartate (NMDA) and L-aspartate currents.	Aspartic Acid	200-211	carbonic anhydrase 1	Rattus norvegicus	140-143
1704112-1	1990	Using whole cell recordings in combination with the concentration clamp technique it was shown that even enzymatically isolated hippocampal CA1 and CA3 neurons exhibit N-methyl-D-aspartate (NMDA) and L-aspartate currents.	Aspartic Acid	200-211	carbonic anhydrase 3	Rattus norvegicus	148-151
1981672-2	1990	Of 18 glutamate residues present in 2 cyanogen bromide fragments of apolipoprotein A-I, 5 residues were cleaved at rates comparable to that of cleavage at the 12 internal aspartate residues present in these polypeptides (all of which were cleaved).	Aspartic Acid	171-180	apolipoprotein A1	Homo sapiens	68-86
2271648-3	1990	PSG9 and PSG10 are representatives of two distinct classes of PSG protein that have N-termini with or without the Arg-Gly-Asp motif implicated in adhesion.	Aspartic Acid	122-125	pregnancy specific beta-1-glycoprotein 9	Homo sapiens	0-4
2271648-3	1990	PSG9 and PSG10 are representatives of two distinct classes of PSG protein that have N-termini with or without the Arg-Gly-Asp motif implicated in adhesion.	Aspartic Acid	122-125	pregnancy specific beta-1-glycoprotein 10, pseudogene	Homo sapiens	9-14
2271648-3	1990	PSG9 and PSG10 are representatives of two distinct classes of PSG protein that have N-termini with or without the Arg-Gly-Asp motif implicated in adhesion.	Aspartic Acid	122-125	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
1981672-1	1990	Asp-N, an endoproteinase specific for cleavage of protein or polypeptide bonds N-terminal to aspartate or cysteic acid residues, has been shown to possess a similar affinity for certain glutamate residues.	Aspartic Acid	93-102	asporin	Homo sapiens	0-5
2266203-7	1990	Both GP2 and GP3 contained low amounts of aromatic and sulphur-containing amino acid residues and large amounts of Asp, Glu, Ser and Leu.	Aspartic Acid	115-118	glycoprotein 2	Bos taurus	5-8
2147282-4	1990	Site-directed mutagenesis of the His-53, Asp-77, and Ser-138 residues of NS3 that compose the proposed catalytic triad implicates this domain as a serine protease.	Aspartic Acid	41-44	KRAS proto-oncogene, GTPase	Homo sapiens	73-76
2147282-4	1990	Site-directed mutagenesis of the His-53, Asp-77, and Ser-138 residues of NS3 that compose the proposed catalytic triad implicates this domain as a serine protease.	Aspartic Acid	41-44	coagulation factor II, thrombin	Homo sapiens	147-162
1980212-1	1990	The role of negatively charged residues in tuning the absorbance spectrum of bovine rhodopsin has been tested by mutating each aspartate and glutamate to asparagine and glutamine, respectively.	Aspartic Acid	127-136	rhodopsin	Bos taurus	84-93
16667849-9	1990	Malate, aspartate, glutamate, citrate, and 2-oxoglutarate were potent inhibitors of PEPC at pH 7 in the absence of glycerol, but their effectiveness was decreased by raising the pH to 8 and/or by adding glycerol.	Aspartic Acid	8-17	phosphoenolpyruvate carboxylase, housekeeping isozyme	Glycine max	84-88
1977471-12	1990	Acta 1028, 281), aspartate and ATP efflux could clearly be correlated with the aspartate/glutamate and the ADP/ATP carrier, respectively.	Aspartic Acid	17-26	WD and tetratricopeptide repeats 1	Homo sapiens	107-122
1980543-3	1990	The uptake and release of aspartate in E1(-) were lower than in E1(+) or ddY.	Aspartic Acid	26-35	small nucleolar RNA, H/ACA box 73a	Mus musculus	39-44
1980543-4	1990	However, the aspartate level in the cerebral cortex of E1(-) was higher compared to that of E1(+) or ddY.	Aspartic Acid	13-22	small nucleolar RNA, H/ACA box 73a	Mus musculus	55-60
1980543-5	1990	Addition of aspartate into the medium resulted to a decreased potassium-stimulated aspartate release in ddY, an increased in E1(-), and no change in E1(+).	Aspartic Acid	12-21	small nucleolar RNA, H/ACA box 73a	Mus musculus	125-130
2254196-1	1990	The objectives of our experiments were 1) to determine the effect of N-methyl-D,L-aspartate (NMA), an agonist of the neuroexcitatory amino acids aspartate and glutamate, on growth hormone (GH) release in ovariectomized ewes, and 2) to determine the effect of naloxone, an opioid antagonist, on the GH response to NMA.	Aspartic Acid	82-91	somatotropin	Ovis aries	173-187
2271602-4	1990	N-Terminal sequencing of EGF-X revealed that about 30% of the polypeptides have been cleaved at the Asp-3/Ser-4 bond.	Aspartic Acid	100-103	epidermal growth factor	Homo sapiens	25-28
2254196-1	1990	The objectives of our experiments were 1) to determine the effect of N-methyl-D,L-aspartate (NMA), an agonist of the neuroexcitatory amino acids aspartate and glutamate, on growth hormone (GH) release in ovariectomized ewes, and 2) to determine the effect of naloxone, an opioid antagonist, on the GH response to NMA.	Aspartic Acid	82-91	somatotropin	Ovis aries	189-191
2174951-1	1990	In vitro results indicated that human placenta-derived aminopeptidase A (APA) was very effective at hydrolyzing aspartate from the angiotensin molecule, thus converting angiotensin II to angiotensin III, but was not active against angiotensin III.	Aspartic Acid	112-121	glutamyl aminopeptidase	Homo sapiens	55-71
2211523-3	1990	vir genes are activated via a cascade of phosphorylation reactions involving a specific aspartic acid residue of the VirG protein.	Aspartic Acid	88-101	two-component response regulator VirG	Agrobacterium tumefaciens	117-121
2211523-5	1990	By mutating conserved and nonconserved aspartic acid residues in the N-terminal domain, we demonstrated that two of three conserved aspartic acid residues located in two different regions are important for the phosphorylation of VirG by VirA phosphate.	Aspartic Acid	39-52	two-component response regulator VirG	Agrobacterium tumefaciens	229-233
2211523-5	1990	By mutating conserved and nonconserved aspartic acid residues in the N-terminal domain, we demonstrated that two of three conserved aspartic acid residues located in two different regions are important for the phosphorylation of VirG by VirA phosphate.	Aspartic Acid	39-52	two-component VirA-like sensor kinase	Agrobacterium tumefaciens	237-241
2211523-5	1990	By mutating conserved and nonconserved aspartic acid residues in the N-terminal domain, we demonstrated that two of three conserved aspartic acid residues located in two different regions are important for the phosphorylation of VirG by VirA phosphate.	Aspartic Acid	132-145	two-component response regulator VirG	Agrobacterium tumefaciens	229-233
2211523-5	1990	By mutating conserved and nonconserved aspartic acid residues in the N-terminal domain, we demonstrated that two of three conserved aspartic acid residues located in two different regions are important for the phosphorylation of VirG by VirA phosphate.	Aspartic Acid	132-145	two-component VirA-like sensor kinase	Agrobacterium tumefaciens	237-241
2217198-7	1990	Based on the analysis of the predicted protein, we have identified a sequence motif Asp-Xaa-Xaa-Ser-Leu-Tyr-Pro-Ser in DNA polymerase II that is highly conserved among a diverse group of DNA polymerases, which include those from humans, yeast, Herpes and vaccinia viruses, and phages T4 and PRD1.	Aspartic Acid	84-87	metalloendopeptidase	Saccharomyces cerevisiae S288C	291-295
2121673-8	1990	These results indicate that CS1 peptide of fibronectin, lacking the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models.	Aspartic Acid	76-79	chorionic somatomammotropin hormone 1	Homo sapiens	28-31
1700420-3	1990	In nascent human placental alkaline phosphatase (PLAP), the PI-G tail is attached to Asp-484.	Aspartic Acid	85-88	alkaline phosphatase, placental	Homo sapiens	17-47
1700420-3	1990	In nascent human placental alkaline phosphatase (PLAP), the PI-G tail is attached to Asp-484.	Aspartic Acid	85-88	alkaline phosphatase, placental	Homo sapiens	49-53
2203790-5	1990	Phosducin is enriched with acidic and sulfur-containing amino acids, having 32 glutamic acid, 16 aspartic acid, 9 methionine, and 5 cysteine residues.	Aspartic Acid	97-110	phosducin	Bos taurus	0-9
2205309-6	1990	Eighty percent of the mutations involved substitution of aspartic acid for glycine (G----A) in the 12th or 13th codons of N-ras or K-ras.	Aspartic Acid	57-70	NRAS proto-oncogene, GTPase	Homo sapiens	122-127
2205309-6	1990	Eighty percent of the mutations involved substitution of aspartic acid for glycine (G----A) in the 12th or 13th codons of N-ras or K-ras.	Aspartic Acid	57-70	KRAS proto-oncogene, GTPase	Homo sapiens	131-136
2176839-0	1990	Glycine-231 residue of the mouse mitochondrial protonmotive cytochrome b: mutation to aspartic acid deranges electron transport.	Aspartic Acid	86-99	cytochrome b, mitochondrial	Mus musculus	60-72
2271539-1	1990	The adaptability of Escherichia coli dihydrofolate reductase (DHFR) is being explored by identifying second-site mutations that can partially suppress the deleterious effect associated with removal of the active-site proton donor aspartic acid-27.	Aspartic Acid	230-243	Dihydrofolate reductase	Escherichia coli	37-60
2271539-1	1990	The adaptability of Escherichia coli dihydrofolate reductase (DHFR) is being explored by identifying second-site mutations that can partially suppress the deleterious effect associated with removal of the active-site proton donor aspartic acid-27.	Aspartic Acid	230-243	Dihydrofolate reductase	Escherichia coli	62-66
2271540-0	1990	Dihydrofolate reductase from Escherichia coli: probing the role of aspartate-27 and phenylalanine-137 in enzyme conformation and the binding of NADPH.	Aspartic Acid	67-76	Dihydrofolate reductase	Escherichia coli	0-23
2394678-4	1990	The chemical stability of the phospho-VirG bond suggested that the VirG protein was phosphorylated at the aspartate and/or glutamate residue.	Aspartic Acid	106-115	two-component response regulator VirG	Agrobacterium tumefaciens	38-42
2209608-6	1990	This was apparently due to cleavage of the -Gln-Asp- linkage in the sequence H2N-Ala-His-Val-Pro-Gln-Gln-Asp-Glu-, analogous to cleavages described for human apo AI and apo CII.	Aspartic Acid	48-51	apolipoprotein A1	Homo sapiens	158-164
2209608-6	1990	This was apparently due to cleavage of the -Gln-Asp- linkage in the sequence H2N-Ala-His-Val-Pro-Gln-Gln-Asp-Glu-, analogous to cleavages described for human apo AI and apo CII.	Aspartic Acid	48-51	apolipoprotein C2	Homo sapiens	169-176
2209608-6	1990	This was apparently due to cleavage of the -Gln-Asp- linkage in the sequence H2N-Ala-His-Val-Pro-Gln-Gln-Asp-Glu-, analogous to cleavages described for human apo AI and apo CII.	Aspartic Acid	105-108	apolipoprotein A1	Homo sapiens	158-164
2209608-6	1990	This was apparently due to cleavage of the -Gln-Asp- linkage in the sequence H2N-Ala-His-Val-Pro-Gln-Gln-Asp-Glu-, analogous to cleavages described for human apo AI and apo CII.	Aspartic Acid	105-108	apolipoprotein C2	Homo sapiens	169-176
2208738-0	1990	Incidence and properties of aspartate aminotransferase-immunoglobulin complexes in patients with a high serum aspartate to alanine aminotransferase ratio.	Aspartic Acid	28-37	glutamic--pyruvic transaminase	Homo sapiens	123-147
2394678-4	1990	The chemical stability of the phospho-VirG bond suggested that the VirG protein was phosphorylated at the aspartate and/or glutamate residue.	Aspartic Acid	106-115	two-component response regulator VirG	Agrobacterium tumefaciens	67-71
2123729-5	1990	At a concentration of 0.01 mM the net movement for phenylalanine, serine, aspartate and glycine was from blood to CSF.	Aspartic Acid	74-83	granulocyte-macrophage colony-stimulating factor	Ovis aries	114-117
2395880-0	1990	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	Aspartic Acid	37-50	complement C4B (Chido blood group)	Homo sapiens	108-122
2395880-0	1990	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	Aspartic Acid	37-50	complement C4A (Rodgers blood group)	Homo sapiens	126-129
2169420-7	1990	Interestingly, four of the six variable positions are Asp in rat HMG-17 which results in an overall net increase in the negative charge of the C-terminal region.	Aspartic Acid	54-57	high mobility group nucleosomal binding domain 2	Rattus norvegicus	65-71
2201686-2	1990	The requirement of an L-aspartate in the P-1 position was confirmed together with the need for a small hydrophobic residue in the P-1" position (Gly or Ala).	Aspartic Acid	22-33	crystallin gamma F, pseudogene	Homo sapiens	41-44
2198286-12	1990	Within two of the domains is an aspartate-rich motif found invariantly in the amino acid sequences of farnesyl pyrophosphate synthetase from three species and the hexaprenyl pyrophosphate synthetase amino acid sequence reported here.	Aspartic Acid	32-41	farnesyl diphosphate synthase	Rattus norvegicus	102-135
2390089-5	1990	The RYD sequence of streptavidin thus mimics RGD (Arg-Gly-Asp), the universal recognition domain present in fibronectin and other adhesion-related molecules.	Aspartic Acid	58-61	fibronectin 1	Homo sapiens	108-119
2271531-10	1990	Insulin mutants [B25-Asp]insulin and [B25-His]insulin display 16- and 20-fold decreases in IDE affinity versus wild-type insulin.	Aspartic Acid	21-24	insulin	Homo sapiens	0-7
2271531-10	1990	Insulin mutants [B25-Asp]insulin and [B25-His]insulin display 16- and 20-fold decreases in IDE affinity versus wild-type insulin.	Aspartic Acid	21-24	insulin	Homo sapiens	25-32
2271531-10	1990	Insulin mutants [B25-Asp]insulin and [B25-His]insulin display 16- and 20-fold decreases in IDE affinity versus wild-type insulin.	Aspartic Acid	21-24	insulin degrading enzyme	Homo sapiens	91-94
1698454-3	1990	Comparison of the amino acid sequences of RNase and angiogenin reveals several striking differences in the region flanking the active-site lysine, including a deletion and a transposition of aspartic acid and proline residues.	Aspartic Acid	191-204	ribonuclease A family member k6	Gallus gallus	52-62
1697752-5	1990	Other features deduced from the bovine IGFBP-2 cDNA include: an abundance of leucine in the pre-peptide, an Arg-Gly-Asp sequence, absence of N-linked glycosylation sites, and an imperfect polyadenylation signal as well as an ATTTA motif in the 3" non-coding DNA.	Aspartic Acid	116-119	insulin like growth factor binding protein 2	Bos taurus	39-46
2272754-4	1990	As we could show for the synthesis of thymulin (FTS, pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn), these two resins with anchoring linkages are well suited for the synthesis of C-terminal Asn peptides using protected aspartic acid derivative as starting material.	Aspartic Acid	210-223	AKT interacting protein	Homo sapiens	48-51
2378988-9	1990	zeta-Globin gene mapping of DNA doubly digested with Bg/II and Asp 718 showed the -alpha 3.7/--SEA genotype, and CCA confirmed homozygous beta E/beta E. The CCA is useful for diagnosing the compound hemoglobin genotypes of Southeast Asians and could be applied also to prenatal diagnosis in this population.	Aspartic Acid	63-66	hemoglobin subunit zeta	Homo sapiens	0-11
2202949-0	1990	Characterization of monoclonal antibodies specific to the activated ras p21 with aspartic acid at position 13.	Aspartic Acid	81-94	H3 histone pseudogene 16	Homo sapiens	72-75
19215371-5	1990	All agents tested (PB, ETYA, ASP) suppressed prolactin secretion induced either by thyrotropin-releasing hormone or vasoactive intestinal peptide.	Aspartic Acid	29-32	prolactin	Rattus norvegicus	45-54
19215371-5	1990	All agents tested (PB, ETYA, ASP) suppressed prolactin secretion induced either by thyrotropin-releasing hormone or vasoactive intestinal peptide.	Aspartic Acid	29-32	thyrotropin releasing hormone	Rattus norvegicus	83-112
2202949-6	1990	Western blot analysis demonstrates that D129 and D146 react specifically with p21 extracted from transformed NIH3T3 fibroblast lines containing aspartic acid at position 13.	Aspartic Acid	144-157	H3 histone pseudogene 16	Homo sapiens	78-81
2202949-7	1990	These studies also demonstrate that D146 is able to detect the activated p21 with aspartic acid at position 13 that is shed into the culture media.	Aspartic Acid	82-95	H3 histone pseudogene 16	Homo sapiens	73-76
2202949-8	1990	Studies demonstrate that MAb D146 specifically immunoprecipitates the cellular p21 with aspartic acid at position 13 from transformed NIH3T3 cells, whereas D129 cannot immunoprecipitate the activated p21.	Aspartic Acid	88-101	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	79-82
2217144-8	1990	This demonstrates that region IV, and at least aspartic acid at position 141, must be involved in the TNF receptor binding site.	Aspartic Acid	47-60	tumor necrosis factor	Homo sapiens	102-105
2202949-9	1990	Using a sandwich ELISA format, D146 is able to detect the p21 with position 13 aspartic acid from cell extracts and culture fluids.	Aspartic Acid	79-92	H3 histone pseudogene 16	Homo sapiens	58-61
2217145-0	1990	Alteration in folding efficiency and conformation of recombinant human tumor necrosis factor-alpha by replacing cysteines 69 and 101 with aspartic acid 69 and arginine 101.	Aspartic Acid	138-151	tumor necrosis factor	Homo sapiens	71-98
2217145-1	1990	An analog of human tumor necrosis factor-alpha (TNF-alpha) was created involving the replacement of Cys69 with Asp and Cys101 with Arg.	Aspartic Acid	111-114	tumor necrosis factor	Homo sapiens	19-46
2202949-10	1990	The ability of D146 to function in the ELISA format raises the possibility that this assay maybe a quick and effective way of determining the presence of activated p21 with aspartic acid at position 13 in human fluids and tissues.	Aspartic Acid	173-186	H3 histone pseudogene 16	Homo sapiens	164-167
2217145-1	1990	An analog of human tumor necrosis factor-alpha (TNF-alpha) was created involving the replacement of Cys69 with Asp and Cys101 with Arg.	Aspartic Acid	111-114	tumor necrosis factor	Homo sapiens	48-57
1982017-1	1990	Angiotensin III is formed by removal of the N-terminal Asp residue of angiotensin II in a reaction catalyzed by glutamyl aminopeptidase (aminopeptidase A EC 3.4.11.7).	Aspartic Acid	55-58	angiotensinogen	Homo sapiens	70-84
2358462-5	1990	However, M-ASGP-BP was characteristic in having a shorter cytoplasmic tail, and an inserted segment of 24 amino acids containing an Arg-Gly-Asp sequence between the membrane-spanning region and carbohydrate recognition domain.	Aspartic Acid	140-143	C-type lectin domain containing 10A	Rattus norvegicus	9-18
1975652-9	1990	Seizure severity (Rb1/Rb2) seems to correlate, in some areas, with additional lower amounts of GABA already reported and, to a lower extent, of Asp (-19% in striatum, inferior colliculus and cerebellum), of Tau and Gly; a tendency for a rise in Gln content was observed in certain others (10-20% in olfactory bulb, thalamus, hypothalamus, substantia nigra, and frontal, temporal and occipital cortex).	Aspartic Acid	144-147	RB transcriptional corepressor 1	Mus musculus	18-21
1975652-9	1990	Seizure severity (Rb1/Rb2) seems to correlate, in some areas, with additional lower amounts of GABA already reported and, to a lower extent, of Asp (-19% in striatum, inferior colliculus and cerebellum), of Tau and Gly; a tendency for a rise in Gln content was observed in certain others (10-20% in olfactory bulb, thalamus, hypothalamus, substantia nigra, and frontal, temporal and occipital cortex).	Aspartic Acid	144-147	RB transcriptional corepressor like 2	Mus musculus	22-25
1978267-1	1990	Methionine sulfoxime (MS) is an inhibitor of glutamine synthetase, an astroglial enzyme believed to be involved in the maintenance of glutamine, a major precursor for neurotransmitter pools of the excitatory amino acids aspartate and glutamate in striatal afferent axon terminals.	Aspartic Acid	220-229	glutamate-ammonia ligase	Rattus norvegicus	45-65
2114233-0	1990	Acceleration of recombinant tissue-type plasminogen activator-induced thrombolysis and prevention of reocclusion by the combination of heparin and the Arg-Gly-Asp-containing peptide bitistatin in a canine model of coronary thrombosis.	Aspartic Acid	159-162	tissue-type plasminogen activator	Canis lupus familiaris	28-61
1972721-7	1990	VLA-5-dependent binding to FN but not costimulation by FN can be specifically blocked with peptides containing the RGD (arg-gly-asp) tripeptide sequence whereas VLA-4-dependent binding and costimulation can both be efficiently inhibited by a 12 amino acid peptide, LHGPEILDVPST (leu-his-gly-pro-glu-iso-leu-asp-val-pro-ser-thr), derived from the alternatively spliced IIICS region of FN.	Aspartic Acid	128-131	integrin subunit alpha 5	Homo sapiens	0-5
1972721-7	1990	VLA-5-dependent binding to FN but not costimulation by FN can be specifically blocked with peptides containing the RGD (arg-gly-asp) tripeptide sequence whereas VLA-4-dependent binding and costimulation can both be efficiently inhibited by a 12 amino acid peptide, LHGPEILDVPST (leu-his-gly-pro-glu-iso-leu-asp-val-pro-ser-thr), derived from the alternatively spliced IIICS region of FN.	Aspartic Acid	128-131	fibronectin 1	Homo sapiens	27-29
1982017-1	1990	Angiotensin III is formed by removal of the N-terminal Asp residue of angiotensin II in a reaction catalyzed by glutamyl aminopeptidase (aminopeptidase A EC 3.4.11.7).	Aspartic Acid	55-58	glutamyl aminopeptidase	Homo sapiens	112-135
1982017-2	1990	Thiol derivatives of glutamate and aspartate in which the alpha-COOH group was replaced by -CH2SH were synthesized as inhibitors of glutamyl aminopeptidase.	Aspartic Acid	35-44	glutamyl aminopeptidase	Homo sapiens	132-155
1982017-4	1990	Aspartate thiol (beta-homocysteine) was a less potent but more selective inhibitor of glutamyl aminopeptidase (glutamyl aminopeptidase: Ki = 1.2 x 10(-6) M; microsomal alanyl aminopeptidase: Ki = 7.5 x 10(-6) M).	Aspartic Acid	0-9	glutamyl aminopeptidase	Homo sapiens	86-109
1982017-4	1990	Aspartate thiol (beta-homocysteine) was a less potent but more selective inhibitor of glutamyl aminopeptidase (glutamyl aminopeptidase: Ki = 1.2 x 10(-6) M; microsomal alanyl aminopeptidase: Ki = 7.5 x 10(-6) M).	Aspartic Acid	0-9	glutamyl aminopeptidase	Homo sapiens	111-134
2348836-1	1990	There is evidence that certain alleles at the HLA-DQ locus are correlated with susceptibility to insulin-dependent diabetes mellitus (IDDM) and in particular that DQ beta-chain alleles containing aspartic acid at position 57 are protective.	Aspartic Acid	196-209	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	163-170
2351666-4	1990	Results obtained with the site-specific variant of oncomodulin known as D59E, in which glutamate replaces the aspartate naturally present at position 59, have necessitated substantial revision of these ideas.	Aspartic Acid	110-119	oncomodulin	Homo sapiens	51-62
2113614-6	1990	Here we report that the expression of I-Ak (A alpha kA beta k) in transgenic NOD mice can also prevent insulitis, and that this protection is seen not only when the I-A beta-chain has aspartic acid as residue 57, but also when this residue is serine.	Aspartic Acid	184-197	aurora kinase A	Mus musculus	38-42
2113614-7	1990	These results show that the single amino-acid substitution at position 57 of the I-A beta-chain from aspartic acid to serine is not sufficient for the development of the disease.	Aspartic Acid	101-114	histocompatibility 2, class II antigen A, beta 1	Mus musculus	81-89
2194578-1	1990	The aromatic region of the 1H-FT-NMR spectrum of the biologically fully-potent, monomeric human insulin mutant, B9 Ser----Asp, B27 Thr----Glu has been investigated in D2O.	Aspartic Acid	122-125	insulin	Homo sapiens	96-103
2194578-5	1990	These comparisons also give the sequence-specific assignments of most of the aromatic resonances of the mutant insulins B16 Tyr----Glu, B27 Thr----Glu and B25 Phe----Asp and the chemically modified species des-(B23-B30) insulin and monoiodo-Tyr A14 insulin.	Aspartic Acid	166-169	insulin	Homo sapiens	111-118
2119367-1	1990	We have investigated the anti-metastatic and anti-invasive activities of polypeptide analogues based on the Arg-Gly-Asp (RGD) adhesive signal in fibronectin, poly(RGD), poly(RGDS)[Arg-Gly-Asp-Ser] and poly(RGDT)[Arg-Gly-Asp-Thr].	Aspartic Acid	116-119	fibronectin 1	Mus musculus	145-156
1693954-0	1990	Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice.	Aspartic Acid	92-101	calcitonin-related polypeptide alpha	Rattus norvegicus	16-47
1693954-6	1990	CGRP (10(-7) M) caused a significant, largely Ca2(+)-independent increase in the basal release of Glu and Asp and a decrease in asparagine.	Aspartic Acid	106-109	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
1693954-7	1990	SP and CGRP potentiated the electrically evoked release of Glu and Asp.	Aspartic Acid	67-70	calcitonin-related polypeptide alpha	Rattus norvegicus	7-11
1693954-10	1990	These results indicate that tachykinins (SP and NKA) and CGRP are capable of modulating the basal and electrically evoked release of endogenous Glu and Asp, and these actions may provide an important mechanism by which the peptides contribute to the regulation of the primary afferent synaptic transmission.	Aspartic Acid	152-155	calcitonin-related polypeptide alpha	Rattus norvegicus	57-61
2190534-4	1990	In purified calmodulin from bovine brain, major sites of methylation were found to originate from the Asp-2 residue near the amino terminus and the Asp-78 residue in the alpha-helix that connects the two globular calcium-binding domains.	Aspartic Acid	102-105	calmodulin	Bos taurus	12-22
2190534-9	1990	We also found that calmodulin isolated from erythrocytes and methylated in vitro contains major methylation sites at Asp-2 and Asp-78/80 but not in the calcium-binding sites.	Aspartic Acid	117-120	calmodulin 1	Homo sapiens	19-29
2192846-9	1990	Members of a fourth family with hyperproinsulinemia have a substitution of B10-His with Asp, resulting in a proinsulin that exhibits markedly altered subcellular sorting behavior.	Aspartic Acid	88-91	insulin	Homo sapiens	37-47
1693626-0	1990	Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells.	Aspartic Acid	57-60	fibronectin 1	Homo sapiens	87-98
1693626-1	1990	Association of a novel beta 1-related subunit with alpha v. We report the isolation from two human neuroblastoma cell lines of an Arg-Gly-Asp-dependent integrin complex capable of binding to vitronectin, fibronectin, and type I collagen.	Aspartic Acid	138-141	vitronectin	Homo sapiens	191-202
1693626-1	1990	Association of a novel beta 1-related subunit with alpha v. We report the isolation from two human neuroblastoma cell lines of an Arg-Gly-Asp-dependent integrin complex capable of binding to vitronectin, fibronectin, and type I collagen.	Aspartic Acid	138-141	fibronectin 1	Homo sapiens	204-215
1693954-11	1990	The enhancement of the basal and the dorsal root stimulation-evoked release of Glu and Asp by tachykinins and CGRP may have important physiological implications for strengthening the synaptic connections in the spinal dorsal horn.	Aspartic Acid	87-90	calcitonin-related polypeptide alpha	Rattus norvegicus	110-114
1698194-1	1990	We have investigated the anti-angiogenic effect of a polymeric peptide based on the Arg-Gly-Asp (RGD) core sequence of fibronectin as a monomer unit, i.e., poly(RGD), in syngeneic mice and in vitro.	Aspartic Acid	92-95	fibronectin 1	Mus musculus	119-130
2114285-5	1990	Similar to other serine proteinases, the coding sequence of the preproacrosin gene is spread over all the five exons of the gene and the three activesite residues His, Asp and Ser are encoded by three different exons.	Aspartic Acid	168-171	acrosin	Homo sapiens	64-77
2349233-1	1990	A 96-kDa protein predicted by the DNA sequence of the Saccharomyces cerevisiae PRP5 gene contains a domain that bears a striking resemblance to a family of RNA helicases characterized by the conserved amino acid sequence Asp-Glu-Ala-Asp (D-E-A-D).	Aspartic Acid	221-224	DEAD-box RNA helicase PRP5	Saccharomyces cerevisiae S288C	79-83
2349233-1	1990	A 96-kDa protein predicted by the DNA sequence of the Saccharomyces cerevisiae PRP5 gene contains a domain that bears a striking resemblance to a family of RNA helicases characterized by the conserved amino acid sequence Asp-Glu-Ala-Asp (D-E-A-D).	Aspartic Acid	233-236	DEAD-box RNA helicase PRP5	Saccharomyces cerevisiae S288C	79-83
2112946-2	1990	The hypothesis that lysine residues 277 or 416 may be involved in stabilization of an active conformation of one-chain t-PA via salt-bridge formation with aspartic acid residue 477 was tested by site-directed mutagenesis.	Aspartic Acid	155-168	plasminogen activator, tissue type	Homo sapiens	119-123
2189404-4	1990	We demonstrate herein that the novel beta 2m has the same sequence as native beta 2m except for the 17th residue from the N-terminus which was identified as Asp instead of Asn in native beta 2m, suggesting a possible deamidation during LT-HD.	Aspartic Acid	157-160	beta-2-microglobulin	Homo sapiens	37-44
2352257-4	1990	A cytosine to guanine base substitution at nucleotide position 681 of the LDL receptor cDNA results in an amino acid change from aspartic acid to glutamic acid at residue 206 in the cysteine rich ligand binding domain of the LDL receptor.	Aspartic Acid	129-142	low density lipoprotein receptor	Homo sapiens	74-86
2352257-4	1990	A cytosine to guanine base substitution at nucleotide position 681 of the LDL receptor cDNA results in an amino acid change from aspartic acid to glutamic acid at residue 206 in the cysteine rich ligand binding domain of the LDL receptor.	Aspartic Acid	129-142	low density lipoprotein receptor	Homo sapiens	225-237
2196558-0	1990	Site-directed mutagenesis of aspartic acid 372 at the ATP binding site of yeast phosphoglycerate kinase: over-expression and characterization of the mutant enzyme.	Aspartic Acid	29-42	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	80-103
1692034-3	1990	Recent cDNA cloning reveals that like other adhesive proteins, Vn contains the sequence Arg-Gly-Asp and binds to some members of the integrin class of adhesive membrane receptors.	Aspartic Acid	96-99	vitronectin	Homo sapiens	63-65
1971172-0	1990	Aspartic acid at position 57 of the HLA-DQ beta chain is not protective against insulin-dependent diabetes mellitus in Japanese people.	Aspartic Acid	0-13	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	40-47
2108144-0	1990	Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH.	Aspartic Acid	8-17	Dihydrofolate reductase	Escherichia coli	24-47
2333977-9	1990	Studies on CCK-7 analogues indicate that N-methylation of the Asp residue is responsible for the observed selectivity for CCK-A receptors.	Aspartic Acid	62-65	cholecystokinin	Homo sapiens	11-14
2333977-9	1990	Studies on CCK-7 analogues indicate that N-methylation of the Asp residue is responsible for the observed selectivity for CCK-A receptors.	Aspartic Acid	62-65	cholecystokinin A receptor	Homo sapiens	122-127
1971172-4	1990	In contrast to Caucasian patients with IDDM, most Japanese patients with IDDM possessed at least one aspartic acid at position 57 of DQ beta.	Aspartic Acid	101-114	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	133-140
1968960-5	1990	With endogenous glutamate, the stimulation of oxidative deamination was accompanied by a decrease in aspartate formation, which suggests a concomitant reduction in flux through aspartate aminotransferase.	Aspartic Acid	101-110	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	177-203
2186807-4	1990	Renin pH dependence was evaluated between pH 4.0 and 8.0 by using a synthetic substrate identical with the amino terminus of porcine angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu*Leu-Val-Tyr-Ser, where the asterisk indicates the scissile peptide bond and the proximal histidine is in italics) and an analogous tetradecapeptide where the proximal histidine was substituted with glutamine.	Aspartic Acid	150-153	renin	Homo sapiens	0-5
2180962-8	1990	The anchorage-independent phenotype of c-sis-overexpressing cells was blocked by the cell adhesion sequence of fibronectin, Arg-Gly-Asp-Ser.	Aspartic Acid	132-135	platelet derived growth factor subunit B	Homo sapiens	39-44
2180962-8	1990	The anchorage-independent phenotype of c-sis-overexpressing cells was blocked by the cell adhesion sequence of fibronectin, Arg-Gly-Asp-Ser.	Aspartic Acid	132-135	fibronectin 1	Homo sapiens	111-122
2182017-0	1990	Endothelin-1 stimulates the release of preloaded [3H]D-aspartate from cultured cerebellar granule cells.	Aspartic Acid	55-64	endothelin 1	Rattus norvegicus	0-12
2182017-3	1990	The ET-induced aspartate release was completely blocked in the absence of extracellular Ca2+, but was unaffected by 1 mM Co2+ or 1 microM dihydropyridine derivatives (nisoldipine and nimodipine).	Aspartic Acid	15-24	endothelin 1	Rattus norvegicus	4-6
2182017-5	1990	Short-term pretreatment of cells with phorbol 12,13-dibutyrate (PDBu) potentiated the ET-induced aspartate release, while long-term pretreatment with PDBu attenuated the release.	Aspartic Acid	97-106	endothelin 1	Rattus norvegicus	86-88
2318314-0	1990	Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1.	Aspartic Acid	30-33	laminin subunit alpha 1	Homo sapiens	46-61
2320569-3	1990	Each of the protein in this family, which range from 47 to 83 residues, contains an Arg-Gly-Asp amino acid sequence found in protein ligands that binds to GPIIb-IIIa, a high (17 +/- 1%) cysteine content conserved in the primary sequence, and a homologous N-terminal region absent only in the echistatin isoforms.	Aspartic Acid	92-95	integrin subunit alpha 2b	Homo sapiens	155-160
2186807-7	1990	Molecular modeling indicates the substrate histidine could hydrogen bond to Asp-226 of the enzyme (renin numbering), thus perturbing the ionization of the catalytic aspartyl groups (Asp-38 and Asp-226).	Aspartic Acid	76-79	renin	Homo sapiens	99-104
2186807-7	1990	Molecular modeling indicates the substrate histidine could hydrogen bond to Asp-226 of the enzyme (renin numbering), thus perturbing the ionization of the catalytic aspartyl groups (Asp-38 and Asp-226).	Aspartic Acid	182-185	renin	Homo sapiens	99-104
2186807-7	1990	Molecular modeling indicates the substrate histidine could hydrogen bond to Asp-226 of the enzyme (renin numbering), thus perturbing the ionization of the catalytic aspartyl groups (Asp-38 and Asp-226).	Aspartic Acid	182-185	renin	Homo sapiens	99-104
2138057-5	1990	A single nucleotide change necessary to confer the prp16-1 suppressor phenotype results in a Tyr----Asp substitution near the "A site" consensus for NTP binding proteins.	Aspartic Acid	100-103	DEAH-box RNA helicase PRP16	Saccharomyces cerevisiae S288C	51-56
1971172-5	1990	This finding strongly suggests that aspartic acid at position 57 of DQ beta does not protect the Japanese from IDDM.	Aspartic Acid	36-49	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	68-75
2328849-5	1990	Nevertheless, one of the diabetic children was an Asp 57 homozygote (DQB 1.2/3.1).	Aspartic Acid	50-53	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	69-74
2198059-7	1990	For example, position 3 (+Y) in site 3 of troponin C is always an Asn, whereas in calmodulin the residue is always Asp.	Aspartic Acid	115-118	calmodulin 1	Homo sapiens	82-92
16667350-1	1990	Homoserine dehydrogenase is associated with the multibranched pathway of amino acid biosynthesis originating with aspartic acid.	Aspartic Acid	114-127	bifunctional aspartokinase/homoserine dehydrogenase	Zea mays	0-24
2342602-8	1990	These findings suggest that AAT participates in the synthesis of transmitter aspartate in the medulla oblongata of the rat.	Aspartic Acid	77-86	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	28-31
1969350-11	1990	It is thus proposed that the CD4-HLA class II interaction negatively regulates antigen-independent adhesion of T cells, this interaction involving the highly conserved Arg-Phe-Asp-Ser sequence in the HLA class II beta 1 sequence as a CD4-binding site.	Aspartic Acid	176-179	CD4 molecule	Homo sapiens	29-32
1969350-11	1990	It is thus proposed that the CD4-HLA class II interaction negatively regulates antigen-independent adhesion of T cells, this interaction involving the highly conserved Arg-Phe-Asp-Ser sequence in the HLA class II beta 1 sequence as a CD4-binding site.	Aspartic Acid	176-179	CD4 molecule	Homo sapiens	234-237
2307836-5	1990	We show that CD9-induced aggregation is an active process which proceeds at 37 degrees C, but not at 4 degrees C, requires the expenditure of metabolic energy, and a functioning cytoskeleton, and is not inhibited by Arg-Gly-Asp-Ser peptide.	Aspartic Acid	224-227	CD9 molecule	Homo sapiens	13-16
2107545-5	1990	Our findings indicate that for recognition by CD8-dependent CTLs, residue 227 must be either glutamic acid or aspartic acid and cannot be either basic or uncharged.	Aspartic Acid	110-123	CD8a molecule	Homo sapiens	46-49
2300572-6	1990	(iv) Asp-57-encoding DQB1 alleles are associated with reduced susceptibility to type 1 diabetes in Caucasians.	Aspartic Acid	5-8	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	21-25
2404571-0	1990	Glycine to aspartic acid mutations at codon 13 of the c-Ki-ras gene in human gastrointestinal cancers.	Aspartic Acid	11-24	KRAS proto-oncogene, GTPase	Homo sapiens	54-62
2404571-6	1990	In all three mutations of c-Ki-ras at codon 13 which had been seldom found in human cancers, glycine to aspartic acid mutations due to identical G to A transition at the second nucleotide were observed.	Aspartic Acid	104-117	KRAS proto-oncogene, GTPase	Homo sapiens	26-34
2227136-0	1990	High frequency of aspartic acid at position 57 of HLA-DQ beta-chain in Japanese IDDM patients and nondiabetic subjects.	Aspartic Acid	18-31	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	50-61
2227136-3	1990	Thirty-five (48.6%) IDDM patients had both alleles carrying an aspartic acid at position 57 of the DQ beta-chain (Asp 57), 35 (48.6%) were Asp 57/non-Asp 57 heterozygous, and 2 (2.8%) had non-Asp 57 alleles only.	Aspartic Acid	63-76	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	99-106
2227136-3	1990	Thirty-five (48.6%) IDDM patients had both alleles carrying an aspartic acid at position 57 of the DQ beta-chain (Asp 57), 35 (48.6%) were Asp 57/non-Asp 57 heterozygous, and 2 (2.8%) had non-Asp 57 alleles only.	Aspartic Acid	114-117	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	99-106
2227136-6	1990	Therefore, the Asp 57 hypothesis that the presence of an aspartic acid at position 57 of DQ beta-chain provides protection against developing IDDM is not tenable for Japanese IDDM patients.	Aspartic Acid	15-18	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	89-96
2227136-6	1990	Therefore, the Asp 57 hypothesis that the presence of an aspartic acid at position 57 of DQ beta-chain provides protection against developing IDDM is not tenable for Japanese IDDM patients.	Aspartic Acid	57-70	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	89-96
2300572-8	1990	By DNA sequence analysis, both of these Japanese haplotypes have Asp-57-encoding DQB1 alleles.	Aspartic Acid	65-68	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	81-85
2300572-9	1990	Oligonucleotide dot blot analysis showed that all, except 1, of the 49 Japanese patients and all of the 31 controls have at least one Asp-57-encoding DQB1 allele.	Aspartic Acid	134-137	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	150-154
2300572-10	1990	In addition, 40% of the patients were homozygous for Asp-57-encoding DQB1 alleles versus 35% of the controls.	Aspartic Acid	53-56	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	69-73
2300572-11	1990	The high frequencies of Asp-57-encoding DQB1 alleles in this ethnic group may account for the rarity of type 1 diabetes in Japan.	Aspartic Acid	24-27	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	40-44
2295630-1	1990	The malate-aspartate shuttle, consisting of mitochondrial and cytosolic aspartate aminotransferase and mitochondrial and cytosolic malate dehydrogenase, is a major pathway for the transport of reducing equivalents from cytosol to mitochondria in mammals.	Aspartic Acid	11-20	glutamic-oxaloacetic transaminase 1, soluble	Mus musculus	62-98
2295630-1	1990	The malate-aspartate shuttle, consisting of mitochondrial and cytosolic aspartate aminotransferase and mitochondrial and cytosolic malate dehydrogenase, is a major pathway for the transport of reducing equivalents from cytosol to mitochondria in mammals.	Aspartic Acid	11-20	malate dehydrogenase 1, NAD (soluble)	Mus musculus	103-151
1967219-4	1990	At onset, Gly (GGT) was changed to Ser (AGT) at codon 12, and at relapse, Gly (GGT) to Asp (GAT) was observed at the same codon.	Aspartic Acid	87-90	glycine-N-acyltransferase	Homo sapiens	92-95
2105232-1	1990	Site-specific mutagenesis was employed to investigate the proposed contribution of proton-donating residues (Glu, Asp) in the membrane domains of bovine rhodopsin to protonation of the Schiff base-linking protein and chromophore or to wavelength modulation of this visual pigment.	Aspartic Acid	114-117	rhodopsin	Bos taurus	153-162
2105083-7	1990	A peptide analogous to the calcium binding regions of calmodulin, Asp-Lys-Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys-Glu, is also converted, upon heating, to chromatographically different forms in reversed-phase chromatography.	Aspartic Acid	66-69	calmodulin 1	Homo sapiens	54-64
1688433-2	1990	Analysis of a 953-base pair cDNA that encodes MMCP-2 revealed that this serine protease is a basically charged protein, possessing the histidine-aspartic acid-serine charge relay system that is characteristic of other serine proteases.	Aspartic Acid	145-158	mast cell protease 2	Mus musculus	46-52
1688433-2	1990	Analysis of a 953-base pair cDNA that encodes MMCP-2 revealed that this serine protease is a basically charged protein, possessing the histidine-aspartic acid-serine charge relay system that is characteristic of other serine proteases.	Aspartic Acid	145-158	complement component 1, s subcomponent 1	Mus musculus	72-87
1715119-2	1990	This peptide represents residues Glu1737-Ser1750 of the mature von Willebrand factor (vWF) subunit and contains the sequence Arg-Gly-Asp, thought to be important in mediating binding to the platelet receptor glycoprotein (GP) IIb-IIIa complex.	Aspartic Acid	133-136	von Willebrand factor	Homo sapiens	86-89
1715119-5	1990	In particular, two antibodies bound to epitopes on vWF that included one or more of the three residues (arginine, glycine, aspartic acid) thought to be involved in binding to GP IIb-IIIa, whereas one antibody bound to an epitope that did not include any of those residues.	Aspartic Acid	123-136	von Willebrand factor	Homo sapiens	51-54
1715119-7	1990	In spite of the cross-reactivity for binding to vWF, only the two antibodies whose epitopes included residues in the Arg-Gly-Asp sequence inhibited vWF interaction with GP IIb-IIIa.	Aspartic Acid	125-128	von Willebrand factor	Homo sapiens	148-151
1715119-7	1990	In spite of the cross-reactivity for binding to vWF, only the two antibodies whose epitopes included residues in the Arg-Gly-Asp sequence inhibited vWF interaction with GP IIb-IIIa.	Aspartic Acid	125-128	integrin subunit alpha 2b	Homo sapiens	169-175
2105083-7	1990	A peptide analogous to the calcium binding regions of calmodulin, Asp-Lys-Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys-Glu, is also converted, upon heating, to chromatographically different forms in reversed-phase chromatography.	Aspartic Acid	74-77	calmodulin 1	Homo sapiens	54-64
2152870-0	1990	Glutamate receptors of the non-N-methyl-D-aspartic acid type mediate the increase in luteinizing hormone-releasing hormone release by excitatory amino acids in vitro.	Aspartic Acid	42-55	gonadotropin releasing hormone 1	Rattus norvegicus	85-122
1965949-1	1990	The platelet adhesion on adhesive protein-coated surfaces was significantly reduced by the addition of the synthetic tetrapeptide, RGDS (Arg-Gly-Asp-Ser), which was identified as the common amino acid sequence of adhesive site of adhesive proteins.	Aspartic Acid	145-148	ral guanine nucleotide dissociation stimulator	Homo sapiens	131-135
2085665-3	1990	It is suggested that in diabetes may exist a deficiency, inactivity or unavailability of Biotin, resulting in disordered activity of biotin-dependent enzyme, pyruvate carboxylase, leading to accumulation of pyruvate and/or depletion of aspartate, both of which play a significant role in nervous system metabolism.	Aspartic Acid	236-245	pyruvate carboxylase	Homo sapiens	158-178
2210066-3	1990	In the analysis of DQ beta variation in DR4, DRw6, and DR2 haplotypes, a correlation was observed between the presence of the negatively charged residue Asp at position 57 and low susceptibility and the presence of an Ala (DR4), Val (DRw6), or Ser (DR2) and higher susceptibility.	Aspartic Acid	153-156	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	19-26
2210066-3	1990	In the analysis of DQ beta variation in DR4, DRw6, and DR2 haplotypes, a correlation was observed between the presence of the negatively charged residue Asp at position 57 and low susceptibility and the presence of an Ala (DR4), Val (DRw6), or Ser (DR2) and higher susceptibility.	Aspartic Acid	153-156	major histocompatibility complex, class II, DR beta 4	Homo sapiens	40-43
2210066-3	1990	In the analysis of DQ beta variation in DR4, DRw6, and DR2 haplotypes, a correlation was observed between the presence of the negatively charged residue Asp at position 57 and low susceptibility and the presence of an Ala (DR4), Val (DRw6), or Ser (DR2) and higher susceptibility.	Aspartic Acid	153-156	major histocompatibility complex, class II, DR beta 4	Homo sapiens	223-226
12106022-2	1990	Glutamate and aspartate potentiate in a concentration-dependent manner the effect of VIP.	Aspartic Acid	14-23	vasoactive intestinal polypeptide	Mus musculus	85-88
1968835-5	1990	The activity of urinary GOT and GPT, which convert Asp and alanine, respectively, to Glu in normal subjects was significantly greater than in calcium stone formation.	Aspartic Acid	51-54	glutamic--pyruvic transaminase	Homo sapiens	32-35
2193150-8	1990	The migration-promoting effect of fibronectin can be specifically inhibited both in vivo and in vitro by antibodies to fibronectin, integrin receptors, or by peptides containing the Arg-Gly-Asp-Ser sequence.	Aspartic Acid	190-193	fibronectin 1	Homo sapiens	34-45
1983218-3	1990	Dot-blot analysis of amplified DNA with 32P-labeled probes located the mutation in codon 27 of the minor alpha 1-globin gene; the change involved a GAG (coding for glutamic acid) to GAT (coding for aspartic acid) mutation.	Aspartic Acid	198-211	glycine-N-acyltransferase	Homo sapiens	182-185
12106022-8	1990	Thus, based on this metabotropic action, EAA can be categorized into the following classes: (i) those that potentiate the effect of VIP, such as glutamate, aspartate, kainate and ibotenate; (ii) those that inhibit the effect of VIP, such as l-homocysteate and quisqualate; and (iii) those that are ineffective, such as NMDA and d-homocysteate.	Aspartic Acid	156-165	vasoactive intestinal polypeptide	Mus musculus	132-135
12106023-7	1990	In area CA1, K+-stimulated, Ca2+-dependent release of [14C]aspartate was significantly increased in conditioned animals.	Aspartic Acid	59-68	carbonic anhydrase 1	Rattus norvegicus	8-11
12106023-7	1990	In area CA1, K+-stimulated, Ca2+-dependent release of [14C]aspartate was significantly increased in conditioned animals.	Aspartic Acid	59-68	carbonic anhydrase 2	Rattus norvegicus	28-31
2139657-7	1990	The carboxyl-terminal residue of CPB-II was identified as aspartic acid by the hydrazinolytic procedure.	Aspartic Acid	58-71	annexin A6	Homo sapiens	33-39
2193150-9	1990	Neural crest cells recognize two major adhesion sites along fibronectin molecules; these are the Arg-Gly-Asp-Ser sequence located in the medial part of the molecule and the CS1 site situated in the alternatively spliced IIICS region.	Aspartic Acid	105-108	fibronectin 1	Homo sapiens	60-71
1975451-0	1990	Regulation of glutamate and aspartate release from the Schaffer collaterals and other projections of CA3 hippocampal pyramidal cells.	Aspartic Acid	28-37	carbonic anhydrase 3	Homo sapiens	101-104
1689473-3	1990	Calcitonin gene-related peptide (CGRP 10(-7) M) produced a significant increase in the concentrations of glutamate and aspartate in the perfusate.	Aspartic Acid	119-128	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
1689473-6	1990	These results indicate that SP and CGRP are capable of modulating the basal efflux of endogenous aspartate and glutamate and this modulation may represent one of the mechanisms by which these peptides contribute to primary afferent synaptic transmission.	Aspartic Acid	97-106	calcitonin-related polypeptide alpha	Rattus norvegicus	35-39
2172848-1	1990	Infusion of an acidic amino acid, L-aspartate, to 10 volunteers resulted in transient, significant increases in urinary excretion of the major urinary trypsin inhibitor (p less than 0.002) and beta 2-microglobulin (p less than 0.02).	Aspartic Acid	34-45	beta-2-microglobulin	Homo sapiens	193-213
2195556-6	1990	This suggests that Asp 70 is part of the anionic site, and that the absence of this negatively charged amino acid explains the reduced affinity of atypical cholinesterase for positively charged substrates and inhibitors.	Aspartic Acid	19-22	butyrylcholinesterase	Homo sapiens	156-170
2153284-0	1990	Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.	Aspartic Acid	145-148	alkaline phosphatase, placental	Homo sapiens	156-186
2153284-3	1990	The COOH-terminal domain of pre-pro-PLAP provides a signal for processing during which a largely hydrophobic 29-residue COOH-terminal peptide is removed, and the PI-G moiety is added to the newly exposed Asp-484 terminus.	Aspartic Acid	204-207	alkaline phosphatase, placental	Homo sapiens	36-40
1975451-2	1990	To explore this issue, we have studied the release of endogenous glutamate and aspartate from synaptic terminals of the CA3-derived Schaffer collateral, commissural and ipsilateral associational fibers in slices of hippocampal area CA1.	Aspartic Acid	79-88	carbonic anhydrase 3	Homo sapiens	120-123
1975451-8	1990	Superfusion of CA1 slices with a glucose-deficient medium increases the release of both amino acids and reduces the glutamate/aspartate ratio.	Aspartic Acid	126-135	carbonic anhydrase 1	Homo sapiens	15-18
33779415-1	2021	Canavan disease is an autosomal recessive leukodystrophy caused by mutations in the gene encoding aspartoacylase (ASPA), which hydrolyses N-acetylaspartate (NAA) to acetate and aspartate.	Aspartic Acid	146-155	aspartoacylase	Felis catus	98-112
3096340-1	1986	A decapeptide corresponding to residues 35-44(-Thr-Ile-Glu-Asp-Ser-Tyr-Arg-Lys-Gln-Val-) of p21ras was synthesized.	Aspartic Acid	59-62	Harvey rat sarcoma virus oncogene	Mus musculus	92-98
33940558-3	2021	In response to DNA strand breaks, PARP1 covalently attaches ADP-ribose moieties to arginine, glutamate, aspartate, cysteine, lysine, and serine acceptor sites on both itself and other proteins.	Aspartic Acid	104-113	poly(ADP-ribose) polymerase 1	Homo sapiens	34-39
33800686-4	2021	In this study, we investigated whether the PD-causative 620 aspartate (D) to asparagine (N) mutation in the vacuolar protein sorting 35 ortholog (Vps35) precipitated herpes simplex virus (HSV) infection.	Aspartic Acid	60-69	VPS35 retromer complex component	Homo sapiens	146-151
33779415-1	2021	Canavan disease is an autosomal recessive leukodystrophy caused by mutations in the gene encoding aspartoacylase (ASPA), which hydrolyses N-acetylaspartate (NAA) to acetate and aspartate.	Aspartic Acid	146-155	aspartoacylase	Felis catus	114-118
33804322-11	2021	Molecular docking speculated that C3G could form hydrogen bonds with alpha-glucosidase by binding to the active sit (Leu 313, Ser 157, Tyr 158, Phe 314, Arg 315, and two Asp 307).	Aspartic Acid	170-173	sucrase-isomaltase	Homo sapiens	69-86
33810495-1	2021	L-aspartate (Asp) serves as a central building block, in addition to being a constituent of proteins, for many metabolic processes in most organisms, such as biosynthesis of other amino acids, nucleotides, nicotinamide adenine dinucleotide (NAD), the tricarboxylic acid (TCA) cycle and glycolysis pathway intermediates, and hormones, which are vital for growth and defense.	Aspartic Acid	0-11	assembly factor for spindle microtubules	Homo sapiens	13-16
33807850-7	2021	The mutants also preserved the state of the structurally critical aspartate-phenylalanine-glycine (DFG)-motif and regulatory spine (R-spine), which were altered in wild-type EGFR.	Aspartic Acid	66-75	epidermal growth factor receptor	Homo sapiens	174-178
33807852-3	2021	In vivo, Par-4 is cleaved by caspase-3 at Asp-131 to generate the 25 kDa functionally active cleaved Par-4 protein (cl-Par-4) that inhibits NF-kappaB-mediated cell survival pathways and causes selective apoptosis in tumor cells.	Aspartic Acid	42-45	pro-apoptotic WT1 regulator	Homo sapiens	9-14
33807852-3	2021	In vivo, Par-4 is cleaved by caspase-3 at Asp-131 to generate the 25 kDa functionally active cleaved Par-4 protein (cl-Par-4) that inhibits NF-kappaB-mediated cell survival pathways and causes selective apoptosis in tumor cells.	Aspartic Acid	42-45	caspase 3	Homo sapiens	29-38
33807852-3	2021	In vivo, Par-4 is cleaved by caspase-3 at Asp-131 to generate the 25 kDa functionally active cleaved Par-4 protein (cl-Par-4) that inhibits NF-kappaB-mediated cell survival pathways and causes selective apoptosis in tumor cells.	Aspartic Acid	42-45	pro-apoptotic WT1 regulator	Homo sapiens	101-106
8070361-2	1994	The rat PACE4 sequence has the Asp-His-Ser catalytic site triad, an Arg-Gly-Asp potential integrin binding site, and three potential sites for N-linked glycosylation.	Aspartic Acid	31-34	proprotein convertase subtilisin/kexin type 6	Rattus norvegicus	8-13
32890999-7	2020	A molecular docking study supported this result, showing a good interaction of the amino group with aspartic acid residues of the catalytic diade of BACE-1.	Aspartic Acid	100-113	beta-secretase 1	Homo sapiens	149-155
25140573-1	2015	Previous studies have shown the association between the polymorphisms serine (S) or aspartic acid (D) at codon 146 of the PRNP gene and resistance to scrapie.	Aspartic Acid	84-97	major prion protein	Capra hircus	122-126
21454541-3	2011	Using a yeast two-hybrid approach, we found that the PKCdelta C1b domain associates with p23 and identified two key residues (Asp(245) and Met(266)) implicated in this interaction.	Aspartic Acid	126-129	protein kinase C delta	Homo sapiens	53-61
18987303-1	2009	Transgenic (Tg) mice expressing approximately 95% of the D166V (aspartic acid to valine) mutation in the ventricular myosin regulatory light chain (RLC) shown to cause a malignant familial hypertrophic cardiomyopathy (FHC) phenotype were generated, and the skinned and intact papillary muscle fibers from the Tg-D166V mice were examined using a Guth muscle research system.	Aspartic Acid	64-77	myosin, light polypeptide 2, regulatory, cardiac, slow	Mus musculus	105-146
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Aspartic Acid	95-98	adenosylhomocysteinase like 1	Homo sapiens	24-29
26123492-9	2015	Palmitate specifically increased expression of the pyruvate carriers MPC1 and MPC2, whereas the glutamate carrier GC1 and the aspartate/glutamate carrier AGC1 were down-regulated by palmitate and oleate, respectively.	Aspartic Acid	126-135	aggrecan	Homo sapiens	154-158
26123492-12	2015	Interestingly, transcript levels of the carriers for aspartate/glutamate AGC2, malate DIC and malate/oxaloacetate/aspartate UCP2 were increased by high glucose, a profile suggesting important mitochondrial anaplerotic/cataplerotic activities and NADPH-generating shuttles.	Aspartic Acid	114-123	uncoupling protein 2	Homo sapiens	124-128
21647837-5	2012	Crucial to this achievement were the initial identification of a ligand-efficient isothiourea fragment through target-based NMR screening and the determination of its X-ray crystal structure in complex with BACE-1, which revealed an extensive H-bond network with the two active site aspartate residues.	Aspartic Acid	283-292	beta-secretase 1	Homo sapiens	207-213
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	47-50	ski sarcoma viral oncogene homolog (avian)	Mus musculus	41-44
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	47-50	ski sarcoma viral oncogene homolog (avian)	Mus musculus	79-82
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	47-50	ski sarcoma viral oncogene homolog (avian)	Mus musculus	79-82
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	47-50	ski sarcoma viral oncogene homolog (avian)	Mus musculus	79-82
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	47-50	ski sarcoma viral oncogene homolog (avian)	Mus musculus	79-82
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	189-192	ski sarcoma viral oncogene homolog (avian)	Mus musculus	41-44
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	189-192	ski sarcoma viral oncogene homolog (avian)	Mus musculus	79-82
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	189-192	ski sarcoma viral oncogene homolog (avian)	Mus musculus	79-82
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	189-192	ski sarcoma viral oncogene homolog (avian)	Mus musculus	79-82
20598402-5	2010	The pharmacokinetic study indicated that SKI-I-Asp cleaved efficiently to form SKI-I and the half-life of SKI-I was increased from approximately 7 h in SKI-I to approximately 10 h in SKI-I-Asp injected mice, thereby prolonging its effect.	Aspartic Acid	189-192	ski sarcoma viral oncogene homolog (avian)	Mus musculus	79-82
16219779-0	2006	Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae.	Aspartic Acid	55-65	Hsp90 cochaperone STI1	Saccharomyces cerevisiae S288C	87-91
16219779-0	2006	Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae.	Aspartic Acid	55-65	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	95-100
34773872-7	2022	Quantitative conformational analysis further confirmed the atomic-scale computational chemistry conclusions, and the perturbation of (S)-pyraclofos on the AChE"s ordered conformation was lower than that of (R)-pyraclofos, which is germane to the interaction energies of the crucial residues, e.g. Tyr-124, Tyr-337, Asp-74, Trp-86, and Tyr-119.	Aspartic Acid	315-318	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
34977390-9	2022	At normal energy supplementation, Gln, Glu, and Asp restored small intestinal energy homeostasis via replenishing the Krebs" cycle and down-regulating the AMPK (adenosine monophosphate activated protein kinase) pathway.	Aspartic Acid	48-51	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	155-159
34977390-9	2022	At normal energy supplementation, Gln, Glu, and Asp restored small intestinal energy homeostasis via replenishing the Krebs" cycle and down-regulating the AMPK (adenosine monophosphate activated protein kinase) pathway.	Aspartic Acid	48-51	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	161-209
34922186-4	2022	In each breed, there were eight nucleotide variations within the MTNR1A gene exon II, two of which (g.17355358 and g.17355171), respectively, resulted in a valine to isoleucine, and alanine to aspartic acid substitution, in amino acid sequence.	Aspartic Acid	193-206	melatonin receptor type 1A	Ovis aries	65-71
34818016-4	2022	Examination of a large set of human brain samples revealed a striking relationship between Alzheimer"s disease (AD) status and isomerization of aspartic acid in a peptide from tau.	Aspartic Acid	144-157	microtubule associated protein tau	Homo sapiens	176-179
34895333-9	2021	The expression of catalytically dead HK1 stimulated similar changes in levels of TCA intermediates, aspartate and cysteine, and in glutamate as were induced by the HK2 deletion.	Aspartic Acid	100-109	hexokinase 1	Homo sapiens	37-40
34969094-4	2022	For example, it is now known that NGLY1 can also act as an "editing enzyme" to convert N-glycosylated asparagine residues to aspartate residues, thus introducing negative charges into a core peptide and modulating the function of the target molecule.	Aspartic Acid	125-134	N-glycanase 1	Homo sapiens	34-39
34965441-6	2022	We detected PFC metabolite levels by liquid chromatography-tandem mass spectrometry and found significant upregulation of 5-hydroxyindoleacetic acid, kynurenine, 5-hydroxytryptamine, ornithine and glutamine, and downregulation of 5-hydroxytryptophan, glutamic acid and aspartic acid in PEDF-overexpressing mice compared with control mice, in which no such changes were detected.	Aspartic Acid	269-282	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	286-290
34862755-1	2022	BACKGROUND: The gene ENPEP encodes glutamyl aminopeptidase, which can cut N-terminal aspartic acid from angiotensin II, and is related to tumorigenesis and immune microenvironment, however, the association between the expression of ENPEP and benefits of immune checkpoint inhibitors (ICIs) has had no investigation.	Aspartic Acid	85-98	glutamyl aminopeptidase	Homo sapiens	21-26
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Aspartic Acid	3-6	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	107-111
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Aspartic Acid	3-6	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	144-148
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Aspartic Acid	3-6	Protein-tyrosine phosphatase-like, PTPLA	Arabidopsis thaliana	153-157
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Aspartic Acid	3-6	3-oxo-5-alpha-steroid 4-dehydrogenase family protein	Arabidopsis thaliana	161-164
34894237-6	2021	An Asp (339 aa) residue of KCS9 is involved in its homo- and hetero-interactions with ECR.	Aspartic Acid	3-6	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	27-31
34894237-6	2021	An Asp (339 aa) residue of KCS9 is involved in its homo- and hetero-interactions with ECR.	Aspartic Acid	3-6	3-oxo-5-alpha-steroid 4-dehydrogenase family protein	Arabidopsis thaliana	86-89
34894237-7	2021	Complementation analysis of Arabidopsis kcs9 mutant by the expression of amino acid-substituted KCS9 mutant genes showed that 5) Two Asp residues (308 and 339 aa) of KCS9 are involved in the synthesis of C24 VLCFAs from C22.	Aspartic Acid	133-136	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	40-44
34894237-7	2021	Complementation analysis of Arabidopsis kcs9 mutant by the expression of amino acid-substituted KCS9 mutant genes showed that 5) Two Asp residues (308 and 339 aa) of KCS9 are involved in the synthesis of C24 VLCFAs from C22.	Aspartic Acid	133-136	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	96-100
34894237-7	2021	Complementation analysis of Arabidopsis kcs9 mutant by the expression of amino acid-substituted KCS9 mutant genes showed that 5) Two Asp residues (308 and 339 aa) of KCS9 are involved in the synthesis of C24 VLCFAs from C22.	Aspartic Acid	133-136	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	166-170
34861885-9	2021	Finally, we demonstrate that conservation of cellular aspartate, regulation of nitric oxide synthesis, and pyrimidine production play pivotal roles in ASS1+ASL-mediated growth suppression in ccRCC.	Aspartic Acid	54-63	argininosuccinate synthase 1	Homo sapiens	151-155
34861885-9	2021	Finally, we demonstrate that conservation of cellular aspartate, regulation of nitric oxide synthesis, and pyrimidine production play pivotal roles in ASS1+ASL-mediated growth suppression in ccRCC.	Aspartic Acid	54-63	argininosuccinate lyase	Homo sapiens	156-159
34861885-12	2021	Loss of ASS1 and ASL helps cells redirect aspartate towards pyrimidine synthesis and support enhanced proliferation.	Aspartic Acid	42-51	argininosuccinate synthase 1	Homo sapiens	8-12
34862755-1	2022	BACKGROUND: The gene ENPEP encodes glutamyl aminopeptidase, which can cut N-terminal aspartic acid from angiotensin II, and is related to tumorigenesis and immune microenvironment, however, the association between the expression of ENPEP and benefits of immune checkpoint inhibitors (ICIs) has had no investigation.	Aspartic Acid	85-98	angiotensinogen	Homo sapiens	104-118
34861885-12	2021	Loss of ASS1 and ASL helps cells redirect aspartate towards pyrimidine synthesis and support enhanced proliferation.	Aspartic Acid	42-51	argininosuccinate lyase	Homo sapiens	17-20
34862755-1	2022	BACKGROUND: The gene ENPEP encodes glutamyl aminopeptidase, which can cut N-terminal aspartic acid from angiotensin II, and is related to tumorigenesis and immune microenvironment, however, the association between the expression of ENPEP and benefits of immune checkpoint inhibitors (ICIs) has had no investigation.	Aspartic Acid	85-98	glutamyl aminopeptidase	Homo sapiens	232-237
34887660-4	2021	This dual responsive nanoparticle with negatively charged surface first respond to the extracellular PSMA and then to the intracellular esterase, achieving a programmable release of CPT at the tumor site and producing the byproducts of biocompatible glutamic acid and aspartic acid.	Aspartic Acid	268-281	folate hydrolase 1	Homo sapiens	101-105
34643096-1	2021	The activation peptide of mammalian trypsinogens typically contains a tetra-aspartate motif (positions P2-P5 in Schechter-Berger numbering) that inhibits autoactivation and facilitates activation by enteropeptidase.	Aspartic Acid	76-85	transmembrane serine protease 15	Homo sapiens	199-214
34227245-0	2021	Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells.	Aspartic Acid	26-35	KRAS proto-oncogene, GTPase	Homo sapiens	10-14
34537373-7	2021	Moreover, we found that anti-fibrotic activity of DR8 was closely related to the residues aspartic acid (Asp)1, histidine (His)2, proline (Pro)5 and glutamine (Gln)6, which suggested that the position of residues asparagine (Asn)3, asparagine (Asn)4, isoleucine (Ile)7 and arginine (Arg)8 could be further modified to optimized its anti-fibrotic effect.	Aspartic Acid	90-103	audiogenic seizure prone 1	Mus musculus	105-110
34227245-3	2021	We show that expression of KRASG13D upregulates aspartate metabolizing proteins including PCK1, PCK2, ASNS and ASS1.	Aspartic Acid	48-57	phosphoenolpyruvate carboxykinase 1	Homo sapiens	90-94
34227245-3	2021	We show that expression of KRASG13D upregulates aspartate metabolizing proteins including PCK1, PCK2, ASNS and ASS1.	Aspartic Acid	48-57	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	96-100
34227245-3	2021	We show that expression of KRASG13D upregulates aspartate metabolizing proteins including PCK1, PCK2, ASNS and ASS1.	Aspartic Acid	48-57	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	102-106
34227245-3	2021	We show that expression of KRASG13D upregulates aspartate metabolizing proteins including PCK1, PCK2, ASNS and ASS1.	Aspartic Acid	48-57	argininosuccinate synthase 1	Homo sapiens	111-115
34247034-4	2021	Homologous modeling and molecular docking results indicated that the key amino acids of KA/2A9/3 scFv are TYR-92 (CDRL3), SER-93 (CDRL3), ASP-155 (CDRH1) and GLY-226 (CDRH3), and the hydrogen bond is the main force.	Aspartic Acid	138-141	immunglobulin heavy chain variable region	Homo sapiens	97-101
34811544-0	2021	Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.	Aspartic Acid	14-23	tumor necrosis factor	Homo sapiens	34-37
34811544-4	2021	Shortage of mitochondrial aspartate disrupted the regeneration of the metabolic cofactor nicotinamide adenine dinucleotide, causing ADP deribosylation of the endoplasmic reticulum (ER) sensor GRP78/BiP.	Aspartic Acid	26-35	heat shock protein family A (Hsp70) member 5	Homo sapiens	192-197
34811544-4	2021	Shortage of mitochondrial aspartate disrupted the regeneration of the metabolic cofactor nicotinamide adenine dinucleotide, causing ADP deribosylation of the endoplasmic reticulum (ER) sensor GRP78/BiP.	Aspartic Acid	26-35	heat shock protein family A (Hsp70) member 5	Homo sapiens	198-201
34811544-7	2021	Transfer of intact mitochondria into T cells, as well as supplementation of exogenous aspartate, rescued the mitochondria-instructed expansion of ER membranes and suppressed TNF release and rheumatoid tissue inflammation.	Aspartic Acid	86-95	tumor necrosis factor	Homo sapiens	174-177
34819510-2	2021	Here we report a de novo heterozygous missense variant of the PSMB9 proteasome subunit gene in two unrelated Japanese infants resulting in amino acid substitution of the glycine (G) by aspartic acid (D) at position 156 of the encoded protein beta1i.	Aspartic Acid	185-198	proteasome 20S subunit beta 9	Homo sapiens	62-67
34901821-0	2021	HIF-1alpha overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction.	Aspartic Acid	97-106	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
34819510-2	2021	Here we report a de novo heterozygous missense variant of the PSMB9 proteasome subunit gene in two unrelated Japanese infants resulting in amino acid substitution of the glycine (G) by aspartic acid (D) at position 156 of the encoded protein beta1i.	Aspartic Acid	185-198	proteasome 20S subunit beta 9	Homo sapiens	242-248
34795260-5	2021	HPF1 rapidly associates/dissociates from multiple PARP1 molecules, initiating serine modification before modification initiates on glutamate/aspartate, and accelerating initiation to be more comparable to elongation reactions forming poly(ADP-ribose).	Aspartic Acid	141-150	histone PARylation factor 1	Homo sapiens	0-4
34811740-9	2022	Mutagenesis of C-terminal aspartic acid residues resulted in attenuation of beta-arrestin 2 translocation, which translated to a reduction in desensitisation of G protein activation.	Aspartic Acid	26-39	arrestin beta 2	Homo sapiens	76-91
34795260-5	2021	HPF1 rapidly associates/dissociates from multiple PARP1 molecules, initiating serine modification before modification initiates on glutamate/aspartate, and accelerating initiation to be more comparable to elongation reactions forming poly(ADP-ribose).	Aspartic Acid	141-150	poly(ADP-ribose) polymerase 1	Homo sapiens	50-55
34792662-5	2021	RESULTS: Widespread alterations were evident in alanine, aspartate, glutamate, and arginine metabolism in Ndufs4 KO mice; while brain-region specific metabolic signatures include the accumulation of branched-chain amino acids, proline, and glycolytic intermediates.	Aspartic Acid	57-66	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	106-112
34426189-5	2021	We measured plasma concentrations of glucose and six amino acids that can regulate insulin secretion, including aspartate (Asp), glutamate (Glu), glutamine (Gln), alanine (Ala), Arginine (Arg), and ornithine (Orn).	Aspartic Acid	123-126	insulin	Homo sapiens	83-90
34426189-8	2021	These results suggest that exposure to certain nitro-PAHs affects glucose homeostasis, partly resulting from the depletion of insulin-stimulating amino acids (Asp, Glu, and Orn).	Aspartic Acid	159-162	insulin	Homo sapiens	126-133
34228977-2	2021	New clues in better understanding the pathogenesis of HCC might relate to the metabolic context in patients with citrin (aspartate-glutamate carrier 1) deficiency (CD).	Aspartic Acid	121-130	solute carrier family 25 member 13	Homo sapiens	113-119
34766381-5	2022	We also demonstrated that like UHRF1, the aromatic amino acids within the TTD are important for binding to H3K9me3 and a conserved aspartic acid within the PHD forms an ionic interaction with R2 of H3.	Aspartic Acid	131-144	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	31-36
34728685-1	2021	L-asparaginase (ASNase, EC 3.5.1.1) is an enzyme that catalyzes the L-asparagine hydrolysis into L-aspartic acid and ammonia, being mainly applied in pharmaceutical and food industries.	Aspartic Acid	97-112	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
34728685-1	2021	L-asparaginase (ASNase, EC 3.5.1.1) is an enzyme that catalyzes the L-asparagine hydrolysis into L-aspartic acid and ammonia, being mainly applied in pharmaceutical and food industries.	Aspartic Acid	97-112	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-22
34833901-1	2021	A recombinant formulation of silk fibroin containing the arginine-glycine-aspartic acid (RGD) cell-binding motif (RGD-fibroin) offers potential advantages for the cultivation of corneal cells.	Aspartic Acid	74-87	fibroin light chain	Bombyx mori	34-41
34833901-1	2021	A recombinant formulation of silk fibroin containing the arginine-glycine-aspartic acid (RGD) cell-binding motif (RGD-fibroin) offers potential advantages for the cultivation of corneal cells.	Aspartic Acid	74-87	fibroin light chain	Bombyx mori	118-125
34450065-4	2021	Overexpression of the glutamate/aspartate transporter, Glast, or deletion of glutamic-oxaloacetic transaminase 1 (Got1) each increased aspartate levels in HSCs/progenitor cells and increased the function of HSCs but not colony-forming progenitors.	Aspartic Acid	135-144	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	55-60
34450065-4	2021	Overexpression of the glutamate/aspartate transporter, Glast, or deletion of glutamic-oxaloacetic transaminase 1 (Got1) each increased aspartate levels in HSCs/progenitor cells and increased the function of HSCs but not colony-forming progenitors.	Aspartic Acid	135-144	glutamic-oxaloacetic transaminase 1, soluble	Mus musculus	77-112
34450065-4	2021	Overexpression of the glutamate/aspartate transporter, Glast, or deletion of glutamic-oxaloacetic transaminase 1 (Got1) each increased aspartate levels in HSCs/progenitor cells and increased the function of HSCs but not colony-forming progenitors.	Aspartic Acid	135-144	glutamic-oxaloacetic transaminase 1, soluble	Mus musculus	114-118
34450065-5	2021	Conversely, deletion of Got2 reduced aspartate levels and the function of HSCs but not colony-forming progenitors.	Aspartic Acid	37-46	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	24-28
34347311-9	2021	The Ac-SDpsiKP analogue (whereby the peptide bond between the aspartate and lysine is reduced) peptide inhibited TGF-beta/ small mother against decapentaplegic (Smad)-3 signalling and collagen deposition.	Aspartic Acid	62-71	transforming growth factor alpha	Homo sapiens	113-121
34403736-7	2021	Furthermore, the primary association signal in the HLA class II region was located within the HLA-DQ gene region, most likely due to HLA-DQB1, particularly the amino acid position 57 (aspartic acid/alanine) in the peptide binding groove, or an intergenic SNP upstream of HLA-DQB1.	Aspartic Acid	184-197	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	51-54
34403736-7	2021	Furthermore, the primary association signal in the HLA class II region was located within the HLA-DQ gene region, most likely due to HLA-DQB1, particularly the amino acid position 57 (aspartic acid/alanine) in the peptide binding groove, or an intergenic SNP upstream of HLA-DQB1.	Aspartic Acid	184-197	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	94-97
34403736-7	2021	Furthermore, the primary association signal in the HLA class II region was located within the HLA-DQ gene region, most likely due to HLA-DQB1, particularly the amino acid position 57 (aspartic acid/alanine) in the peptide binding groove, or an intergenic SNP upstream of HLA-DQB1.	Aspartic Acid	184-197	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	133-141
34347311-9	2021	The Ac-SDpsiKP analogue (whereby the peptide bond between the aspartate and lysine is reduced) peptide inhibited TGF-beta/ small mother against decapentaplegic (Smad)-3 signalling and collagen deposition.	Aspartic Acid	62-71	SMAD family member 3	Homo sapiens	123-168
34686667-6	2021	First, metabolomics analysis reveals that Ripk1 deficiency specifically increases aspartate levels in both mouse neonates and mammalian cells under starvation conditions.	Aspartic Acid	82-91	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	42-47
34280745-6	2021	The intercalation of Asp2- and CO32- caused 003 peaks in XRD sharper and d003 decreased from 8.15 A to 7.70 A which is assigned to Ca2Al-LDH(Asp, CO3).	Aspartic Acid	141-144	beta-secretase 1	Homo sapiens	21-25
34303878-10	2021	Metabolomics and metabolite tracing studies revealed that insulin-mTORC1-ATF4 signaling stimulates pathways of non-essential amino acid synthesis in primary hepatocytes, including those of alanine, aspartate, methionine, and cysteine, but not serine.	Aspartic Acid	198-207	CREB regulated transcription coactivator 1	Mus musculus	66-72
34303878-10	2021	Metabolomics and metabolite tracing studies revealed that insulin-mTORC1-ATF4 signaling stimulates pathways of non-essential amino acid synthesis in primary hepatocytes, including those of alanine, aspartate, methionine, and cysteine, but not serine.	Aspartic Acid	198-207	activating transcription factor 4	Mus musculus	73-77
34707294-4	2021	The transmembrane channel and Na+ binding are disrupted in DISP1-NNN, a variant with asparagine substitutions for three intramembrane aspartate residues that each coordinate and neutralize the charge of one of the three Na+ ions.	Aspartic Acid	134-143	dispatched RND transporter family member 1	Mus musculus	59-64
34715056-4	2022	Disrupting mitochondrial metabolism via chemical inhibition of electron transport, deletion of the malate-aspartate shuttle component GOT1, or endogenous mutations in tricarboxylic acid cycle enzymes, causes synthetic lethality with KL-11743.	Aspartic Acid	106-115	glutamic-oxaloacetic transaminase 1	Homo sapiens	134-138
34686667-0	2021	RIPK1 regulates starvation resistance by modulating aspartate catabolism.	Aspartic Acid	52-61	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	0-5
34686667-7	2021	Increased aspartate in Ripk1-/- cells enhances the TCA  flux and ATP production.	Aspartic Acid	10-19	receptor interacting serine/threonine kinase 1	Homo sapiens	23-28
34686667-9	2021	Transcriptional analyses demonstrate that Ripk1-/- deficiency downregulates gene expression in aspartate catabolism by inactivating SP1.	Aspartic Acid	95-104	receptor interacting serine/threonine kinase 1	Homo sapiens	42-47
34745126-0	2021	Aspartate Metabolism Facilitates IL-1beta Production in Inflammatory Macrophages.	Aspartic Acid	0-9	interleukin 1 alpha	Mus musculus	33-41
34745126-2	2021	Here, we found that the metabolites in aspartate metabolism are depleted in lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma)-stimulated macrophages.	Aspartic Acid	39-48	interferon gamma	Mus musculus	106-133
34745126-3	2021	Aspartate promotes interleukin-1beta (IL-1beta) secretion in M1 macrophages.	Aspartic Acid	0-9	interleukin 1 beta	Mus musculus	19-36
34712849-0	2021	Role of aspartic acid residues D87 and D89 in APS kinase domain of human 3"-phosphoadenosine 5"-phosphosulfate synthase 1 and 2b: A commonality with phosphatases/kinases.	Aspartic Acid	8-21	3'-phosphoadenosine 5'-phosphosulfate synthase 1	Homo sapiens	73-128
34745126-3	2021	Aspartate promotes interleukin-1beta (IL-1beta) secretion in M1 macrophages.	Aspartic Acid	0-9	interleukin 1 alpha	Mus musculus	38-46
34745126-4	2021	Mechanistically, aspartate boosts the activation of hypoxia-inducible factor-1alpha (HIF-1alpha) and inflammasome and increases the levels of metabolites in aspartate metabolism, such as asparagine.	Aspartic Acid	17-26	hypoxia inducible factor 1, alpha subunit	Mus musculus	52-83
34745126-4	2021	Mechanistically, aspartate boosts the activation of hypoxia-inducible factor-1alpha (HIF-1alpha) and inflammasome and increases the levels of metabolites in aspartate metabolism, such as asparagine.	Aspartic Acid	17-26	hypoxia inducible factor 1, alpha subunit	Mus musculus	85-95
34543426-2	2021	HAAH hydroxylates epidermal-like growth factor (EGF) domains to form the beta-hydroxylated product from substrate asparagine or aspartic acid and has been suggested to have a negative impact in a variety of cancers.	Aspartic Acid	128-141	aspartate beta-hydroxylase	Homo sapiens	0-4
34795871-3	2021	The reason for the enhancement in the selectivity of the benzohydroxamate-based compounds is the presence of specific interactions between the fluorinated linker and the key residues Gly582, Ser531, and His614 of zHDAC6, which are hindered in class I HDAC isoforms by the presence of an Aspartate that replaces Ser531.	Aspartic Acid	287-296	histone deacetylase 6	Danio rerio	213-219
34543426-2	2021	HAAH hydroxylates epidermal-like growth factor (EGF) domains to form the beta-hydroxylated product from substrate asparagine or aspartic acid and has been suggested to have a negative impact in a variety of cancers.	Aspartic Acid	128-141	epidermal growth factor	Homo sapiens	18-46
34543426-2	2021	HAAH hydroxylates epidermal-like growth factor (EGF) domains to form the beta-hydroxylated product from substrate asparagine or aspartic acid and has been suggested to have a negative impact in a variety of cancers.	Aspartic Acid	128-141	epidermal growth factor	Homo sapiens	48-51
34641473-5	2021	The molecular docking study showed maximum XP docking scores (-11.265, -10.532, -10.422, -10.827, -10.753 kcal/mol) for potent pyrazole analogs (42, 46, 49, 56, 43), respectively, with significant interactions with amino acid residues (ASP 594, CYS 532, PHE 583, SER 536) against TRAP1 kinase receptors (PDB ID: 5Y3N).	Aspartic Acid	236-239	TNF receptor associated protein 1	Homo sapiens	280-285
34472145-0	2021	Bovine serum albumin-coated titanium dioxide modified electrochemical interface for enantioselective discrimination of D/L-aspartic acid.	Aspartic Acid	123-136	albumin	Homo sapiens	13-20
34472145-2	2021	Herein, the bovine serum albumin-coated titanium dioxide (bovine serum albumin (BSA)/TiO2 ) was modified as a novel electrochemical interface for efficient, simple, and enantioselective discrimination of aspartic acid enantiomers (D/L-Asp) based on the electrochemical impedance spectroscopy (EIS).	Aspartic Acid	204-217	albumin	Homo sapiens	19-32
34472145-2	2021	Herein, the bovine serum albumin-coated titanium dioxide (bovine serum albumin (BSA)/TiO2 ) was modified as a novel electrochemical interface for efficient, simple, and enantioselective discrimination of aspartic acid enantiomers (D/L-Asp) based on the electrochemical impedance spectroscopy (EIS).	Aspartic Acid	204-217	albumin	Homo sapiens	71-78
34534913-7	2021	In liver, RGS6 forms a direct complex with ATM kinase supported by key aspartate residues in the RGS domain and is both necessary and sufficient to drive hyperlipidemia-dependent ATM phosphorylation.	Aspartic Acid	71-80	regulator of G protein signaling 6	Homo sapiens	10-14
34534913-7	2021	In liver, RGS6 forms a direct complex with ATM kinase supported by key aspartate residues in the RGS domain and is both necessary and sufficient to drive hyperlipidemia-dependent ATM phosphorylation.	Aspartic Acid	71-80	ATM serine/threonine kinase	Homo sapiens	43-46
34246800-7	2021	CPV variants were typed as either CPV-2a, CPV-2b, or CPV-2c on account of amino acid Asn, Asp, or Glu residue, respectively, at VP2 position 426.	Aspartic Acid	90-93	VP2	Canine parvovirus	128-131
34759999-4	2021	On the other hand, among 14 detected mutations in the SARS-CoV-2 S protein that provide advantages to virus for transmission and evasion form treatment, the D614G mutation (substitution of aspartic acid (D) with glycine (G) in codon 614 was particular which could provide the facilitation of the transmission of the virus and virulence.	Aspartic Acid	189-202	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	65-66
34515265-8	2021	Our results also revealed an important role of the lysine residues of P62 in the binding process by forming initial contacts with aspartic acids on the fibril surface.	Aspartic Acid	130-144	nucleoporin 62	Homo sapiens	70-73
34559197-8	2022	The wildtype aspartate residue at amino acid position 438 is directly involved in the dimerization of OPA1 monomers.	Aspartic Acid	13-22	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	102-106
34576163-2	2021	In our previous studies, we reported the robust neuroprotective effects of the icosamer OPN peptide OPNpt20, containing arginine-glycine-aspartic acid (RGD) and serine-leucine-alanine-tyrosine (SLAY) motifs, in an animal model of transient focal ischemia and demonstrated that its anti-inflammatory, pro-angiogenic, and phagocytosis inducing functions are responsible for the neuroprotective effects.	Aspartic Acid	137-150	secreted phosphoprotein 1	Rattus norvegicus	88-91
34603012-8	2021	Interestingly, hiPSC-derived astrocytes with APP and PSEN-1 mutations exhibited decreased amino acid synthesis of glutamate, glutamine, and aspartate derived from leucine metabolism.	Aspartic Acid	140-149	presenilin 1	Homo sapiens	53-59
34571997-8	2021	However, the incorporation of the label into all isotopomers of glutamate, glutamine, GABA and aspartate was lower in SIRT3 KO brain, reflecting decreased activity of mitochondrial and TCA cycle metabolism in both neurons and astrocytes.	Aspartic Acid	95-104	sirtuin 3	Mus musculus	118-123
34473925-1	2021	Understanding the role of polymers rich in aspartic acid (Asp) and glutamic acid (Glu) is the key to gaining precise control over mineralization processes.	Aspartic Acid	43-56	assembly factor for spindle microtubules	Homo sapiens	58-61
34477360-3	2021	Interestingly, genetic deletion of N-acetyltransferase-8-like (NAT8L), which encodes aspartate N-aceyltransferase (ANAT), an enzyme responsible for the synthesis of NAA from l-aspartate and acetyl-CoA, leads to normalization of NAA levels and improvement of symptoms in several genetically engineered mouse models of CD.	Aspartic Acid	174-185	N-acetyltransferase 8-like	Mus musculus	35-61
34477360-3	2021	Interestingly, genetic deletion of N-acetyltransferase-8-like (NAT8L), which encodes aspartate N-aceyltransferase (ANAT), an enzyme responsible for the synthesis of NAA from l-aspartate and acetyl-CoA, leads to normalization of NAA levels and improvement of symptoms in several genetically engineered mouse models of CD.	Aspartic Acid	174-185	N-acetyltransferase 8-like	Mus musculus	63-68
34579420-6	2021	Phosphorylation activates the PEPC enzyme, making it more sensitive to glucose-6-phosphate and less sensitive to malate or aspartate.	Aspartic Acid	123-132	phosphoenolpyruvate carboxykinase 1	Homo sapiens	30-34
34352100-6	2021	Substitutions of the invariant NiRAN residues abolish NMPylation, whereas substitution of a catalytic RdRp Asp residue does not.	Aspartic Acid	107-110	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	102-106
34483819-8	2021	The first time was opposite to the trends of change of GOT2, aspartic acid, and the number of neurons, while the second was consistent with these trends, suggesting that HIF-1alpha may have a two-way induction effect on neurons by regulating GOT2 after HI.	Aspartic Acid	61-74	hypoxia inducible factor 1 subunit alpha	Sus scrofa	170-180
34490587-10	2021	CONCLUSION: Glutamate and glutathione metabolism, aspartate metabolism, urea metabolism and triglyceride metabolism were significantly changed in the Hb Bart"s group compared to the control group.	Aspartic Acid	50-59	ADP ribosylation factor like GTPase 2 binding protein	Homo sapiens	153-157
34365659-7	2021	In this study, we identified CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as one such cell-intrinsic negative regulator of inflammation.	Aspartic Acid	84-97	CREB binding protein	Mus musculus	29-33
34365659-7	2021	In this study, we identified CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as one such cell-intrinsic negative regulator of inflammation.	Aspartic Acid	84-97	E1A binding protein p300	Mus musculus	33-37
34365659-7	2021	In this study, we identified CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as one such cell-intrinsic negative regulator of inflammation.	Aspartic Acid	84-97	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	131-137
34514259-4	2021	The biophysical and computational data elaborated in the study provides an improved understanding of the C5a-C5aR1 interaction at an atomistic resolution, highlighting the energetic importance of the aspartic acids on the NT-peptide of C5aR1 toward binding of C5a.	Aspartic Acid	200-214	complement C5a receptor 1	Homo sapiens	105-114
34514259-4	2021	The biophysical and computational data elaborated in the study provides an improved understanding of the C5a-C5aR1 interaction at an atomistic resolution, highlighting the energetic importance of the aspartic acids on the NT-peptide of C5aR1 toward binding of C5a.	Aspartic Acid	200-214	complement C5a receptor 1	Homo sapiens	236-241
34514259-4	2021	The biophysical and computational data elaborated in the study provides an improved understanding of the C5a-C5aR1 interaction at an atomistic resolution, highlighting the energetic importance of the aspartic acids on the NT-peptide of C5aR1 toward binding of C5a.	Aspartic Acid	200-214	complement C5a receptor 1	Homo sapiens	260-263
34502566-5	2021	In the MDCK cysts, hOCT2 was expressed in the basolateral membrane domain and showed a significant uptake of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP+) with an affinity (Km) of 3.6 +- 1.2 microM, similar to what was measured in the hOCT2-HEK cells (Km = 3.1 +- 0.2 microM).	Aspartic Acid	188-192	solute carrier family 22 member 2	Homo sapiens	19-24
34502566-6	2021	ASP+ uptake was inhibited by tetraethylammonium (TEA+), tetrapentylammonium (TPA+), metformin and baricitinib both in the hOCT2-HEK cells and the hOCT2- MDCK cysts, even though the apparent affinities of TEA+ and baricitinib were dependent on the expression system.	Aspartic Acid	0-4	solute carrier family 22 member 2	Homo sapiens	122-127
34502566-6	2021	ASP+ uptake was inhibited by tetraethylammonium (TEA+), tetrapentylammonium (TPA+), metformin and baricitinib both in the hOCT2-HEK cells and the hOCT2- MDCK cysts, even though the apparent affinities of TEA+ and baricitinib were dependent on the expression system.	Aspartic Acid	0-4	solute carrier family 22 member 2	Homo sapiens	146-151
34573036-1	2021	Neuronal N-acetylaspartate production appears in the presence of aspartate N-acetyltransferase (NAT8L) and binds acetyl groups from acetyl-CoA with aspartic acid.	Aspartic Acid	65-74	N-acetyltransferase 8-like	Rattus norvegicus	96-101
34573036-1	2021	Neuronal N-acetylaspartate production appears in the presence of aspartate N-acetyltransferase (NAT8L) and binds acetyl groups from acetyl-CoA with aspartic acid.	Aspartic Acid	148-161	N-acetyltransferase 8-like	Rattus norvegicus	96-101
34193767-6	2021	Here we determined the crystal structure of the plant ATG12b as a complex with the ATG12b-binding region of ATG3 and revealed that ATG12b recognizes the Asp-Met motif in ATG3 via a hydrophobic pocket and a basic residue, which we confirmed critical for the complex formation by mutational analysis.	Aspartic Acid	153-156	autophagy related 3	Homo sapiens	108-112
34193767-6	2021	Here we determined the crystal structure of the plant ATG12b as a complex with the ATG12b-binding region of ATG3 and revealed that ATG12b recognizes the Asp-Met motif in ATG3 via a hydrophobic pocket and a basic residue, which we confirmed critical for the complex formation by mutational analysis.	Aspartic Acid	153-156	autophagy related 3	Homo sapiens	170-174
34446744-3	2021	Here, we investigated whether the second Asp-Pro peptide bond (residues 121-122) of NOTCH3 is cleaved in CADASIL.	Aspartic Acid	41-44	notch receptor 3	Homo sapiens	84-90
34446744-11	2021	These studies demonstrate that the NOTCH3 protein in CADASIL is cleaved in multiple locations at labile Asp-Pro peptide bonds.	Aspartic Acid	104-107	notch receptor 3	Homo sapiens	35-41
34429416-5	2021	Within the CBS, ATPase coupling is mediated by the charge distribution between an aspartate and a lysine.	Aspartic Acid	82-91	dynein axonemal heavy chain 8	Homo sapiens	16-22
34483819-8	2021	The first time was opposite to the trends of change of GOT2, aspartic acid, and the number of neurons, while the second was consistent with these trends, suggesting that HIF-1alpha may have a two-way induction effect on neurons by regulating GOT2 after HI.	Aspartic Acid	61-74	glutamic-oxaloacetic transaminase 2	Sus scrofa	242-246
34338530-4	2021	FX has two independent electron acceptor Fe sites for A- and B-branch electron transfers, depending on the Asp-B575 protonation state, which causes the A1A-to-FX electron transfer to be uphill and the A1B-to-FX electron transfer to be downhill.	Aspartic Acid	107-110	alpha-1-B glycoprotein	Homo sapiens	201-204
34485154-5	2021	Our results show that ASP inhibited 5-FU-induced the decrease in Bcl-2 protein and the increase in Bax protein.	Aspartic Acid	22-25	BCL2 apoptosis regulator	Homo sapiens	65-70
34485154-5	2021	Our results show that ASP inhibited 5-FU-induced the decrease in Bcl-2 protein and the increase in Bax protein.	Aspartic Acid	22-25	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
34485154-6	2021	ASP alleviated 5-FU-induced the increase in alanine aminotransferase (ALT), triglyceride (TG), and aspartate aminotransferase (AST) content; hepatic steatosis; and liver fibrosis.	Aspartic Acid	0-3	glutamic--pyruvic transaminase	Homo sapiens	44-68
34485154-6	2021	ASP alleviated 5-FU-induced the increase in alanine aminotransferase (ALT), triglyceride (TG), and aspartate aminotransferase (AST) content; hepatic steatosis; and liver fibrosis.	Aspartic Acid	0-3	solute carrier family 17 member 5	Homo sapiens	99-125
34485154-6	2021	ASP alleviated 5-FU-induced the increase in alanine aminotransferase (ALT), triglyceride (TG), and aspartate aminotransferase (AST) content; hepatic steatosis; and liver fibrosis.	Aspartic Acid	0-3	solute carrier family 17 member 5	Homo sapiens	127-130
34485154-10	2021	In conclusion, ASP attenuated the 5-FU-induced Nrf2 pathway barrier to reduce oxidative stress injury and thereby inhibit the disorder of lipid anabolism and apoptosis.	Aspartic Acid	15-18	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
34383710-5	2021	Mechanism studies have found that PE could significantly inhibit the phosphorylation of AKT protein and binds to the ASP-184 site.	Aspartic Acid	117-120	thymoma viral proto-oncogene 1	Mus musculus	88-91
34429988-3	2021	This report suggested that concentration of plasma glutamic acid, aspartic acid, and taurine could be biomarkers for ET.	Aspartic Acid	66-79	major facilitator superfamily domain containing 11	Homo sapiens	117-119
34128540-0	2021	Mutation of aspartic acid 199 in USP1 disrupts its deubiquitinating activity and impairs DNA repair.	Aspartic Acid	12-25	ubiquitin specific peptidase 1	Homo sapiens	33-37
34283245-4	2021	HAAH is suspected to play an important role in NOTCH signaling via selective hydroxylation of aspartic acid and asparagine residues of epidermal growth factor (EGF)-like domains.	Aspartic Acid	94-107	aspartate beta-hydroxylase	Homo sapiens	0-4
34376825-7	2022	The primary interaction of SEP-363856 involves binding to the negatively charged aspartate residue (Asp1033.32, TAAR1; Asp1163.32, 5HT1A).	Aspartic Acid	81-90	trace amine associated receptor 1	Homo sapiens	112-117
34376825-7	2022	The primary interaction of SEP-363856 involves binding to the negatively charged aspartate residue (Asp1033.32, TAAR1; Asp1163.32, 5HT1A).	Aspartic Acid	81-90	5-hydroxytryptamine receptor 1A	Homo sapiens	131-136
34128540-2	2021	Recently, the COSMIC mutation database identified a mutation in USP1 at Asp-199 in endometrial cancer.	Aspartic Acid	72-75	ubiquitin specific peptidase 1	Homo sapiens	64-68
34128540-4	2021	The mutation of aspartic acid to alanine (D199A) resulted in failure of USP1 to undergo autocleavage and form a complex with ubiquitin, indicating D199A-Usp1 is catalytically inactive.	Aspartic Acid	16-29	ubiquitin specific peptidase 1	Homo sapiens	72-76
34128540-4	2021	The mutation of aspartic acid to alanine (D199A) resulted in failure of USP1 to undergo autocleavage and form a complex with ubiquitin, indicating D199A-Usp1 is catalytically inactive.	Aspartic Acid	16-29	ubiquitin specific peptidase 1	Homo sapiens	153-157
34128540-8	2021	Collectively, our findings demonstrate the importance of Asp-199 for USP1 activity and suggest the implications of USP1 downregulation in cancer.	Aspartic Acid	57-60	ubiquitin specific peptidase 1	Homo sapiens	69-73
34157285-6	2021	In contrast, MIR2 requires no specific sequences in the CD86 TM domain, but relies primarily on an aspartic acid at position 244 in the CD86 extracellular juxtamembrane region.	Aspartic Acid	99-112	CD86 molecule	Homo sapiens	136-140
34173716-15	2021	l-aspartic acid can affect the expression of PAICS and then inhibit glioma cell proliferation.	Aspartic Acid	0-15	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Homo sapiens	45-50
34335854-10	2021	Conclusion: Our study indicates that HIF-1alpha RNAi combined with ASP inhibits angiogenesis in HCC via the PI3K and MAPK signaling pathways.	Aspartic Acid	67-70	mitogen-activated protein kinase 1	Homo sapiens	117-121
34298755-2	2021	Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells" intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase).	Aspartic Acid	149-158	argininosuccinate lyase	Homo sapiens	203-206
34190569-7	2021	In this paper, other than briefly presenting the theoretical bases of the QM/ELMO/MM technique, we will also discuss its validation on the well-tested deprotonation of acetyl coenzyme A by aspartate in citrate synthase.	Aspartic Acid	189-198	citrate synthase	Homo sapiens	202-218
34372579-6	2021	An Arg located in the structurally equivalent BH1 region of ORFV125 forms an ionic interaction with the conserved Asp in the BH3 motif in a manner that mimics the canonical ionic interaction seen in host Bcl-2:BH3 motif complexes.	Aspartic Acid	114-117	BCL2 apoptosis regulator	Homo sapiens	204-209
34496687-1	2021	Hb Winnipeg (alpha75(EF4)Asp Tyr (alpha2); HBA2: c.226G>T (or HBA1)) is a stable alpha-globin chain variant described in a few articles.	Aspartic Acid	25-28	glycoprotein hormone subunit alpha 2	Homo sapiens	34-40
34254975-10	2021	Finally, amino acid substitution modeling revealed that aspartic acid at position 57 that distinguishes the risk allele HLA-DQB1*05:03 (for CAU and panuveitis) from nonrisk alleles, significantly increased the binding capacity of naturally presented ligands to HLA-DQ.	Aspartic Acid	56-69	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	120-128
34254975-10	2021	Finally, amino acid substitution modeling revealed that aspartic acid at position 57 that distinguishes the risk allele HLA-DQB1*05:03 (for CAU and panuveitis) from nonrisk alleles, significantly increased the binding capacity of naturally presented ligands to HLA-DQ.	Aspartic Acid	56-69	major histocompatibility complex, class II, DR beta 1	Homo sapiens	261-264
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Aspartic Acid	144-147	sucrase-isomaltase	Homo sapiens	61-78
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Aspartic Acid	157-160	sucrase-isomaltase	Homo sapiens	61-78
34381810-0	2021	Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation.	Aspartic Acid	7-16	signal transducer and activator of transcription 3	Mus musculus	111-116
34107280-6	2021	Using a non-cleavable substrate analog, 2"-deoxy-pseudouridine, we determined the first structure of an enzyme-substrate complex for wild-type MBD4, which confirms interactions that mediate lesion recognition and suggests that a catalytic Asp, highly conserved in HhH enzymes, binds the putative nucleophilic water molecule and stabilizes the transition state.	Aspartic Acid	239-242	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	143-147
34298755-2	2021	Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells" intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase).	Aspartic Acid	149-158	argininosuccinate synthase 1	Homo sapiens	163-167
34298755-2	2021	Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells" intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase).	Aspartic Acid	149-158	argininosuccinate synthase 1	Homo sapiens	169-197
34298755-2	2021	Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells" intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase).	Aspartic Acid	149-158	argininosuccinate lyase	Homo sapiens	208-231
34253804-3	2021	Protein L-isoaspartyl methyltransferase (PIMT) is a repair enzyme which recognizes and converts altered isoAsp residues back to normal aspartate.	Aspartic Acid	135-144	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	0-39
34253804-3	2021	Protein L-isoaspartyl methyltransferase (PIMT) is a repair enzyme which recognizes and converts altered isoAsp residues back to normal aspartate.	Aspartic Acid	135-144	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	41-45
34082982-2	2021	We developed a mineralised tissue-derived ECM-modified true bone ceramic (TBC) scaffold for the delivery of aspartic acid-modified bone morphogenic protein-2 (BMP-2) peptide (P28) and assessed its osteogenic capacity.	Aspartic Acid	108-121	bone morphogenetic protein 2	Rattus norvegicus	131-157
34082982-2	2021	We developed a mineralised tissue-derived ECM-modified true bone ceramic (TBC) scaffold for the delivery of aspartic acid-modified bone morphogenic protein-2 (BMP-2) peptide (P28) and assessed its osteogenic capacity.	Aspartic Acid	108-121	bone morphogenetic protein 2	Rattus norvegicus	159-164
34082982-2	2021	We developed a mineralised tissue-derived ECM-modified true bone ceramic (TBC) scaffold for the delivery of aspartic acid-modified bone morphogenic protein-2 (BMP-2) peptide (P28) and assessed its osteogenic capacity.	Aspartic Acid	108-121	golgi SNAP receptor complex member 1	Rattus norvegicus	175-178
34249720-1	2021	Background: The enzyme L-asparaginase (ASRGL1) catalyzes the hydrolysis of L-asparagine (Asn) to L-aspartic acid (Asp) and ammonia.	Aspartic Acid	97-112	asparaginase and isoaspartyl peptidase 1	Homo sapiens	39-45
34155106-3	2021	Here, we study a prototype for these receptors, a DAP12-NKG2C 2:1 heterotrimeric complex, in which the two DAP12 subunits each contribute a single transmembrane Asp residue, and the NKG2C subunit contributes a Lys to form the complex.	Aspartic Acid	161-164	transmembrane immune signaling adaptor TYROBP	Homo sapiens	50-55
34155106-3	2021	Here, we study a prototype for these receptors, a DAP12-NKG2C 2:1 heterotrimeric complex, in which the two DAP12 subunits each contribute a single transmembrane Asp residue, and the NKG2C subunit contributes a Lys to form the complex.	Aspartic Acid	161-164	transmembrane immune signaling adaptor TYROBP	Homo sapiens	107-112
34249720-1	2021	Background: The enzyme L-asparaginase (ASRGL1) catalyzes the hydrolysis of L-asparagine (Asn) to L-aspartic acid (Asp) and ammonia.	Aspartic Acid	114-117	asparaginase and isoaspartyl peptidase 1	Homo sapiens	39-45
34076169-1	2021	L-Asparaginase catalysing the breakdown of L-Asparagine to L-Aspartate and ammonia is an enzyme of therapeutic importance in the treatment of cancer, especially the lymphomas and leukaemia.	Aspartic Acid	59-70	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
34135948-8	2021	Furthermore, the new NiL2 complex was docked with plasma retinol-binding protein 4 (RBP4) (PDB id: 5NU7), which implied that the NiL2 complex bound to Tyrosine 133 and Aspartate 102 amino acids via N-H intermolecular hydrogen bonds.	Aspartic Acid	168-177	retinol binding protein 4	Homo sapiens	57-82
34135948-8	2021	Furthermore, the new NiL2 complex was docked with plasma retinol-binding protein 4 (RBP4) (PDB id: 5NU7), which implied that the NiL2 complex bound to Tyrosine 133 and Aspartate 102 amino acids via N-H intermolecular hydrogen bonds.	Aspartic Acid	168-177	retinol binding protein 4	Homo sapiens	84-88
34234394-4	2021	Our phylogeny analysis of 1947 sequences of S proteins indicated there is a change in amino acid (aa) from aspartate (Group-A) to glycine (Group-B) at position 614, near the receptor- binding domain (RBD; aa positions 331-524).	Aspartic Acid	107-116	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	44-45
34070975-7	2021	Further pathway enrichment and network analyses revealed a substantial effect of Cyp17a1 genotype on associated cardiovascular and obesity-related pathways involving aspartate and L-arginine.	Aspartic Acid	166-175	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	81-88
34068845-6	2021	We determined the kinetic constants using L-cysteine sulfinic acid as substrate, and also showed that human cysteine sulfinic acid decarboxylase is capable to catalyze the decarboxylation-besides its natural substrates L-cysteine sulfinic acid and L-cysteic acid-of L-aspartate and L-glutamate, although with much lower efficiency.	Aspartic Acid	266-277	cysteine sulfinic acid decarboxylase	Homo sapiens	108-144
34141987-1	2021	The aspartate-to-alanine aminotransferase ratio (AAR) is associated with liver fibrosis, but its predictive performance is suboptimal.	Aspartic Acid	4-13	glutamic--pyruvic transaminase	Homo sapiens	17-41
34096924-2	2021	The immunity protein of colicin E3 (Im3) and the immunity protein of bacteriocin (Im-Bac) were identified from prominent b- and/or y-type fragment ions generated by the polypeptide backbone cleavage (PBC) on the C-terminal side of aspartic acid, glutamic acid, and asparagine residues by the aspartic acid effect fragmentation mechanism.	Aspartic Acid	231-244	colicin E1 protein	Escherichia coli	69-80
34096924-2	2021	The immunity protein of colicin E3 (Im3) and the immunity protein of bacteriocin (Im-Bac) were identified from prominent b- and/or y-type fragment ions generated by the polypeptide backbone cleavage (PBC) on the C-terminal side of aspartic acid, glutamic acid, and asparagine residues by the aspartic acid effect fragmentation mechanism.	Aspartic Acid	292-305	colicin E1 protein	Escherichia coli	69-80
34093799-5	2021	ELISA, Western blotting analysis and immunofluorescence assay were used to confirm the effects of ASP on the expressions of HIF-1alpha and VEGF at the protein level.	Aspartic Acid	98-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
34093799-5	2021	ELISA, Western blotting analysis and immunofluorescence assay were used to confirm the effects of ASP on the expressions of HIF-1alpha and VEGF at the protein level.	Aspartic Acid	98-101	vascular endothelial growth factor A	Homo sapiens	139-143
34093799-9	2021	In addition, the inhibitory effect of ASP might be partly attributed to down-regulation of HIF1alpha and VEGF proteins in SK-Hep1 and Hep-3B cells under hypoxic conditions.	Aspartic Acid	38-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-100
34093799-9	2021	In addition, the inhibitory effect of ASP might be partly attributed to down-regulation of HIF1alpha and VEGF proteins in SK-Hep1 and Hep-3B cells under hypoxic conditions.	Aspartic Acid	38-41	vascular endothelial growth factor A	Homo sapiens	105-109
34093799-10	2021	Moreover, signaling pathway study indicated that ASP significantly down-regulated the hypoxia-induced expressions of p-AKT, p-mTOR and p-ERK, while it had little effects on AKT, mTOR and ERK.	Aspartic Acid	49-52	AKT serine/threonine kinase 1	Homo sapiens	119-122
34093799-10	2021	Moreover, signaling pathway study indicated that ASP significantly down-regulated the hypoxia-induced expressions of p-AKT, p-mTOR and p-ERK, while it had little effects on AKT, mTOR and ERK.	Aspartic Acid	49-52	mechanistic target of rapamycin kinase	Homo sapiens	126-130
34093799-10	2021	Moreover, signaling pathway study indicated that ASP significantly down-regulated the hypoxia-induced expressions of p-AKT, p-mTOR and p-ERK, while it had little effects on AKT, mTOR and ERK.	Aspartic Acid	49-52	mitogen-activated protein kinase 1	Homo sapiens	137-140
34093799-11	2021	Besides, SK-Hep1 xenograft tumor models in nude mice further confirmed that the inhibitory effect of ASP on xenograft tumors might be exerted partly via down-regulation of HIF1alpha and VEGF through blocking MAPK and PI3K signaling pathways.	Aspartic Acid	101-104	hypoxia inducible factor 1, alpha subunit	Mus musculus	172-181
34093799-11	2021	Besides, SK-Hep1 xenograft tumor models in nude mice further confirmed that the inhibitory effect of ASP on xenograft tumors might be exerted partly via down-regulation of HIF1alpha and VEGF through blocking MAPK and PI3K signaling pathways.	Aspartic Acid	101-104	vascular endothelial growth factor A	Mus musculus	186-190
34093799-12	2021	Conclusions: Our findings suggested that ASP suppressed the hypoxia-induced migration, invasion and angiogenesis of HCC cells partly through regulating HIF-1alpha/VEGF expression via MAPK and PI3K signaling pathways.	Aspartic Acid	41-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
34093799-12	2021	Conclusions: Our findings suggested that ASP suppressed the hypoxia-induced migration, invasion and angiogenesis of HCC cells partly through regulating HIF-1alpha/VEGF expression via MAPK and PI3K signaling pathways.	Aspartic Acid	41-44	vascular endothelial growth factor A	Mus musculus	163-167
34095874-5	2021	In particular, Cc6 detects changes in amino acid residues, including phenylalanine, tyrosine, tryptophan, cysteine, aspartate, and glutamate.	Aspartic Acid	116-125	NADH:ubiquinone oxidoreductase subunit A9	Homo sapiens	15-18
34193692-4	2021	reported the synthesis of a ribonuclease A (RNase A) in which Asp121 was artificially replaced with different isomerized Asp residues, and experimentally demonstrated that the enzymatic activities of these artificial mutants were completely lost.	Aspartic Acid	121-124	ribonuclease pancreatic	Bos taurus	28-42
34085048-5	2021	ARID1A inactivation increases glutamine utilization and metabolism through the tricarboxylic acid cycle to support aspartate synthesis.	Aspartic Acid	115-124	AT-rich interaction domain 1A	Homo sapiens	0-6
34193692-4	2021	reported the synthesis of a ribonuclease A (RNase A) in which Asp121 was artificially replaced with different isomerized Asp residues, and experimentally demonstrated that the enzymatic activities of these artificial mutants were completely lost.	Aspartic Acid	121-124	ribonuclease pancreatic	Bos taurus	44-51
35447535-1	2022	L-aspartate-alpha-decarboxylase (PanD) is an essential enzyme catalysing the decarboxylation of L-aspartate to beta-alanine in organisms.	Aspartic Acid	0-11	PAND1	Homo sapiens	33-37
34490059-5	2021	The calculated pH effects in pre-fusion spike trimers are modulated mainly by aspartic acid residues, rather than the more familiar histidine role at mild acidic pH.	Aspartic Acid	78-91	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	40-45
35447535-1	2022	L-aspartate-alpha-decarboxylase (PanD) is an essential enzyme catalysing the decarboxylation of L-aspartate to beta-alanine in organisms.	Aspartic Acid	96-107	PAND1	Homo sapiens	33-37
35597930-5	2022	MFG-E8 is a secreted protein with NH2-terminal epidermal growth factor (EGF)-like domains, containing an Arg-Gly-Asp(RGD) sequence that binds alphavbeta3 and alphavbeta5 integrins, and COOH terminal domains C1 and C2, which can bind to lipid membrane with strong affinity.	Aspartic Acid	113-116	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
35183959-3	2022	Amino acid analysis revealed that glutamic acid, aspartic acid, arginine, and leucine were the dominant amino acids lupin protein.	Aspartic Acid	49-62	5'-nucleotidase, cytosolic IIIA	Homo sapiens	116-121
35192933-0	2022	Long noncoding RNA LINC01234 promotes hepatocellular carcinoma progression through orchestrating aspartate metabolic reprogramming.	Aspartic Acid	97-106	long intergenic non-protein coding RNA 1234	Homo sapiens	19-28
35192933-2	2022	Argininosuccinate synthase 1 (ASS1), as a crucial rate-limiting enzyme in aspartate metabolism, participates in repressing tumor progression.	Aspartic Acid	74-83	argininosuccinate synthase 1	Homo sapiens	0-28
35192933-2	2022	Argininosuccinate synthase 1 (ASS1), as a crucial rate-limiting enzyme in aspartate metabolism, participates in repressing tumor progression.	Aspartic Acid	74-83	argininosuccinate synthase 1	Homo sapiens	30-34
35192933-4	2022	Here, we screen LINC01234 as an aspartate metabolism-related lncRNA in HCC.	Aspartic Acid	32-41	long intergenic non-protein coding RNA 1234	Homo sapiens	16-25
35192933-6	2022	LINC01234 promoted cell proliferation, migration, and drug resistance by orchestrating aspartate metabolic reprogramming in HCC cells.	Aspartic Acid	87-96	long intergenic non-protein coding RNA 1234	Homo sapiens	0-9
35192933-7	2022	Mechanistically, LINC01234 downregulated the expression of ASS1, leading to am increased aspartate level and activation of the mammalian target of rapamycin pathway.	Aspartic Acid	89-98	long intergenic non-protein coding RNA 1234	Homo sapiens	17-26
35192933-7	2022	Mechanistically, LINC01234 downregulated the expression of ASS1, leading to am increased aspartate level and activation of the mammalian target of rapamycin pathway.	Aspartic Acid	89-98	argininosuccinate synthase 1	Homo sapiens	59-63
35192933-10	2022	These findings demonstrate that LINC01234 promotes HCC progression by modulating aspartate metabolic reprogramming and might be a prognostic or therapeutic target for HCC.	Aspartic Acid	81-90	long intergenic non-protein coding RNA 1234	Homo sapiens	32-41
35636725-2	2022	ASPA is highly expressed in oligodendrocytes and catalyzes the cleavage of N-acetylaspartate (NAA) to produce aspartate and acetate.	Aspartic Acid	110-119	aspartoacylase	Homo sapiens	0-4
35621115-2	2022	Here, we propose a spin-gapless semiconducting black arsenic-phosphorus (AsP) monolayer halogenated by chlorine (Cl) adatoms and reveal the perfect spin Seebeck effect induced by its SGS character to produce pure thermal spin-current using first-principles calculations.	Aspartic Acid	73-76	spindlin 1	Homo sapiens	19-23
35621115-2	2022	Here, we propose a spin-gapless semiconducting black arsenic-phosphorus (AsP) monolayer halogenated by chlorine (Cl) adatoms and reveal the perfect spin Seebeck effect induced by its SGS character to produce pure thermal spin-current using first-principles calculations.	Aspartic Acid	73-76	spindlin 1	Homo sapiens	148-152
35621115-2	2022	Here, we propose a spin-gapless semiconducting black arsenic-phosphorus (AsP) monolayer halogenated by chlorine (Cl) adatoms and reveal the perfect spin Seebeck effect induced by its SGS character to produce pure thermal spin-current using first-principles calculations.	Aspartic Acid	73-76	spindlin 1	Homo sapiens	221-225
35621115-6	2022	These distinct features suggest the potential applications of the Cl-halogenated AsP monolayer with the SGS character in low-power spin-caloritronic devices.	Aspartic Acid	81-84	spindlin 1	Homo sapiens	131-135
35194938-1	2022	Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development.	Aspartic Acid	60-73	prune exopolyphosphatase 1	Homo sapiens	0-26
35194938-1	2022	Prune exopolyphosphatase-1 (PRUNE1) encodes a member of the aspartic acid-histidine-histidine (DHH) phosphodiesterase superfamily that regulates cell migration and proliferation during brain development.	Aspartic Acid	60-73	prune exopolyphosphatase 1	Homo sapiens	28-34
35580611-0	2022	Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis.	Aspartic Acid	0-9	CREB regulated transcription coactivator 1	Mus musculus	56-62
35580611-4	2022	We here shown in both human cell lines and mouse models that during developmental and pathological angiogenesis, endothelial cells (ECs) use glutaminolysis-derived glutamate to produce aspartate (Asp) via aspartate aminotransferase (AST/GOT).	Aspartic Acid	185-194	transmembrane protease, serine 11d	Mus musculus	233-236
35580611-4	2022	We here shown in both human cell lines and mouse models that during developmental and pathological angiogenesis, endothelial cells (ECs) use glutaminolysis-derived glutamate to produce aspartate (Asp) via aspartate aminotransferase (AST/GOT).	Aspartic Acid	196-199	transmembrane protease, serine 11d	Mus musculus	233-236
35580611-7	2022	These findings identify glutaminolysis-derived Asp as a regulator of mTORC1-dependent endothelial translation and pyrimidine synthesis.	Aspartic Acid	47-50	CREB regulated transcription coactivator 1	Mus musculus	69-75
35522720-4	2022	Although it is believed that Casp2 exerts its effects by hydrolyzing tau at aspartate-314, forming Deltatau314, it is also possible that a noncatalytic mechanism is involved because catalytically dead Casp2 is biologically active in at least one relevant cellular pathway, that is, autophagy.	Aspartic Acid	76-85	caspase 2	Rattus norvegicus	29-34
35598879-8	2022	Indeed, along with the known pathway of aspartate replenishing oxaloacetate, glutamine was shown to fuel citrate synthesis through both glutaminolysis and reductive carboxylation in a GLS1-dependent manner.	Aspartic Acid	40-49	glutaminase	Homo sapiens	184-188
35522720-4	2022	Although it is believed that Casp2 exerts its effects by hydrolyzing tau at aspartate-314, forming Deltatau314, it is also possible that a noncatalytic mechanism is involved because catalytically dead Casp2 is biologically active in at least one relevant cellular pathway, that is, autophagy.	Aspartic Acid	76-85	caspase 2	Rattus norvegicus	201-206
35562847-5	2022	The results showed that a remarkable number of umami fragments presented in myosin and parvalbumin, such as glutamic acid (Glu), aspartic acid (Asp), and Asp- and Glu- containing peptides, whereas sweet amino acids and bitter peptides (e.g., Pro- and Gly- containing peptides) was mainly found in collagen of all fish samples.	Aspartic Acid	129-142	myosin heavy chain 14	Homo sapiens	76-82
35579101-5	2022	After instillation, the presence of integrin-beta1 endows coated nanoparticles with steady adhesion via specific binding to Arg-Gly-Asp sequence on the fibronectin of ocular epithelium, achieving durable retention on ocular surface.	Aspartic Acid	132-135	integrin subunit beta 1	Homo sapiens	36-50
35579101-5	2022	After instillation, the presence of integrin-beta1 endows coated nanoparticles with steady adhesion via specific binding to Arg-Gly-Asp sequence on the fibronectin of ocular epithelium, achieving durable retention on ocular surface.	Aspartic Acid	132-135	fibronectin 1	Homo sapiens	152-163
35562847-5	2022	The results showed that a remarkable number of umami fragments presented in myosin and parvalbumin, such as glutamic acid (Glu), aspartic acid (Asp), and Asp- and Glu- containing peptides, whereas sweet amino acids and bitter peptides (e.g., Pro- and Gly- containing peptides) was mainly found in collagen of all fish samples.	Aspartic Acid	129-142	assembly factor for spindle microtubules	Homo sapiens	144-147
35387872-3	2022	We find that Ca2+-upregulation of glycolysis, pyruvate levels and respiration, but not glucose uptake, all depend on Aralar/AGC1/Slc25a12, the mitochondrial aspartate-glutamate carrier, component of the malate-aspartate shuttle (MAS).	Aspartic Acid	210-219	aggrecan	Mus musculus	124-128
35554494-4	2022	Genetic complementation experiments in budding yeast demonstrate that the conserved aspartate or its analogous asparagine (N) residue in yeast TAF7 is essential for cell viability and thus its mutation to glycine is lethal.	Aspartic Acid	84-93	TATA-binding protein-associated factor TAF7	Saccharomyces cerevisiae S288C	143-147
35387872-3	2022	We find that Ca2+-upregulation of glycolysis, pyruvate levels and respiration, but not glucose uptake, all depend on Aralar/AGC1/Slc25a12, the mitochondrial aspartate-glutamate carrier, component of the malate-aspartate shuttle (MAS).	Aspartic Acid	210-219	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Mus musculus	129-137
35536062-9	2022	CONCLUSIONS: ASP inhibits irradiation-induced oxidative stress and aging of HSCs at least in part by regulating the Sirt1/FoxO1 pathway, thereby delaying aging of HSCs in mice.	Aspartic Acid	13-16	sirtuin 1	Mus musculus	116-121
35536062-9	2022	CONCLUSIONS: ASP inhibits irradiation-induced oxidative stress and aging of HSCs at least in part by regulating the Sirt1/FoxO1 pathway, thereby delaying aging of HSCs in mice.	Aspartic Acid	13-16	forkhead box O1	Mus musculus	122-127
35449337-14	2022	MBL serum levels were significantly lower in workers with obstructive, restrictive, and combined PFT abnormalities compared to those with normal PFTs, and in the workers with Asp.-positive species than the Asp.-negative workers.	Aspartic Acid	175-178	mannose binding lectin 2	Homo sapiens	0-3
35006623-1	2022	Mutation of an invariant aspartate residue in the binding pocket of 14-3-3$\zeta$ isoform to alanine dramatically reduced phosphopeptide binding and induced opening of the binding pocket.	Aspartic Acid	25-34	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	68-81
35472077-2	2022	Many oncohistone mutations occur at Asp and Glu residues, two amino acids known to be ADP-ribosylated (ADPRylated) by PARP-1.	Aspartic Acid	36-39	poly (ADP-ribose) polymerase family, member 1	Mus musculus	118-124
35468885-2	2022	An important group of enzymes has been deprived of this analytical privilege: members of the protein tyrosine phosphatase (PTP) superfamily with catalytic WPD-loops lacking the indispensable general-acid/base within a tryptophan-proline-aspartate/glutamate context.	Aspartic Acid	237-246	protein-tyrosine phosphatase	Arabidopsis thaliana	93-121
35468885-2	2022	An important group of enzymes has been deprived of this analytical privilege: members of the protein tyrosine phosphatase (PTP) superfamily with catalytic WPD-loops lacking the indispensable general-acid/base within a tryptophan-proline-aspartate/glutamate context.	Aspartic Acid	237-246	protein-tyrosine phosphatase	Arabidopsis thaliana	123-126
35534729-5	2022	Mutating aspartate D428 to alanine prevents ammonia binding to SCAP, abolishes SREBP-1 activation and suppresses tumour growth.	Aspartic Acid	9-18	SREBF chaperone	Homo sapiens	63-67
35534729-5	2022	Mutating aspartate D428 to alanine prevents ammonia binding to SCAP, abolishes SREBP-1 activation and suppresses tumour growth.	Aspartic Acid	9-18	sterol regulatory element binding transcription factor 1	Homo sapiens	79-86
35445555-3	2022	We performed single-molecule measurement of L-aspartic Acid (Asp) and L-leucine (Leu) with mercaptoacetic acid (MAA) chemical modified nano-gap.	Aspartic Acid	44-59	assembly factor for spindle microtubules	Homo sapiens	61-64
35331687-4	2022	Biochemical and biophysical analyses revealed that surface-accessible Aspartates of Pf-SUMO determine the efficacy and specificity of SUMO-Ubc9 interactions.	Aspartic Acid	70-80	ubiquitin conjugating enzyme E2 I	Homo sapiens	139-143
35426495-2	2022	Recently, using ultra high-performance liquid chromatography (UHPLC) coupled with drift tube ion mobility mass spectrometry (DTIMS-MS), we documented the extensive Asp isomerization in amyloid-beta (Abeta) peptides depositing in the extracellular cortical plaques (senile plaques) of the AD brain.	Aspartic Acid	164-167	amyloid beta precursor protein	Homo sapiens	185-197
35426495-2	2022	Recently, using ultra high-performance liquid chromatography (UHPLC) coupled with drift tube ion mobility mass spectrometry (DTIMS-MS), we documented the extensive Asp isomerization in amyloid-beta (Abeta) peptides depositing in the extracellular cortical plaques (senile plaques) of the AD brain.	Aspartic Acid	164-167	amyloid beta precursor protein	Homo sapiens	199-204
35149585-7	2022	Overexpression of GAPDHS was sufficient to block melanoma metastasis, while its inhibition promoted metastasis, decreased glycolysis, and increased levels of certain TCA cycle metabolites and their derivatives including citrate, fumarate, malate, and aspartate.	Aspartic Acid	251-260	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	18-24
35230110-1	2022	In this study, surface diffusion of l-aspartic acid-carvedilol (ASP-CAR) co-amorphous systems at different ASP concentrations is measured and correlated with their physical stability.	Aspartic Acid	36-51	assembly factor for spindle microtubules	Homo sapiens	64-67
35230110-1	2022	In this study, surface diffusion of l-aspartic acid-carvedilol (ASP-CAR) co-amorphous systems at different ASP concentrations is measured and correlated with their physical stability.	Aspartic Acid	36-51	CXADR pseudogene 1	Homo sapiens	68-71
35230110-1	2022	In this study, surface diffusion of l-aspartic acid-carvedilol (ASP-CAR) co-amorphous systems at different ASP concentrations is measured and correlated with their physical stability.	Aspartic Acid	36-51	assembly factor for spindle microtubules	Homo sapiens	107-110
35212782-2	2022	The redox state and proliferative activity of PDAC cells are maintained by the conversion of aspartic acid in the cytoplasm into oxaloacetate though aspartate aminotransferase 1 (GOT1).	Aspartic Acid	93-106	glutamic-oxaloacetic transaminase 1	Homo sapiens	149-177
34713990-7	2022	On receiver operating characteristic (ROC) analyses, the area under curve for alanine aminotransferase (ALT), aspartate-to-ALT ratio (AAR), and dAAR for liver disease mortality were 0.74, 0.55, and 0.81, respectively.	Aspartic Acid	110-119	twins	Drosophila melanogaster	134-137
35078036-8	2022	In particular, the glycosamine groups in anthracyclines are stabilized by binding to glutamate and aspartate residues in CYP2J2 forming salt bridge interactions.	Aspartic Acid	99-108	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	121-127
35212782-2	2022	The redox state and proliferative activity of PDAC cells are maintained by the conversion of aspartic acid in the cytoplasm into oxaloacetate though aspartate aminotransferase 1 (GOT1).	Aspartic Acid	93-106	glutamic-oxaloacetic transaminase 1	Homo sapiens	179-183
35433833-5	2022	Besides the hydrogen bonding interactions mediated by the phospho-serine (p-Ser) or corresponding phosphomimic residue Asp/Glu, the hydrophobic interactions from the other amino acids also contribute to the PSD95 GK/SAPAP interaction.	Aspartic Acid	119-122	guanylate kinase 1	Homo sapiens	213-215
35458468-6	2022	Thus, the presence of the readily identifiable conserved BH1 motif sequence "NWGR" of KsBcl-2, as well as highly conserved Arg residue (R86) forms an ionic interaction with the conserved Asp in the BH3 motif in a manner that mimics the canonical ionic interaction seen in host Bcl-2:BH3 motif complexes.	Aspartic Acid	187-190	BCL2 apoptosis regulator	Homo sapiens	277-282
35258781-9	2022	Moreover, RSV exhibited good binding affinity towards SphK1, with docking scores of -8.1 kcal/moL and formed hydrogen bonds with ASP-178 and LEU-268 in SphK1.	Aspartic Acid	129-132	sphingosine kinase 1	Rattus norvegicus	54-59
35347731-5	2022	However, Abeta forms with isomerized and/or racemized Asp and Ser residues require the use of special methods for separation and extra sensitive and selective methods for detection.	Aspartic Acid	54-57	amyloid beta precursor protein	Homo sapiens	9-14
35418808-0	2022	The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo.	Aspartic Acid	89-93	albumin	Homo sapiens	139-146
35418808-3	2022	The biomedical knowledge on OC secretion and cellular transport partly relies on studies using the fluorescent tracer 4-dimethylaminostyryl)-N-methylpyridinium (ASP+), which has been used in many studies of renal excretion mechanisms of organic ions and which could be a candidate as a PET tracer.	Aspartic Acid	161-165	bone gamma-carboxyglutamate protein	Homo sapiens	28-30
35418808-8	2022	Fluorescence emission spectra recorded in vitro of ASP+ alone and in the presence of albumin using both 1-photon excitation and two-photon excitation showed that albumin strongly enhance the emission from ASP+ and induce a shift of the emission maximum from 600 to 570 nm.	Aspartic Acid	51-55	albumin	Homo sapiens	85-92
35418808-8	2022	Fluorescence emission spectra recorded in vitro of ASP+ alone and in the presence of albumin using both 1-photon excitation and two-photon excitation showed that albumin strongly enhance the emission from ASP+ and induce a shift of the emission maximum from 600 to 570 nm.	Aspartic Acid	51-55	albumin	Homo sapiens	162-169
35418808-8	2022	Fluorescence emission spectra recorded in vitro of ASP+ alone and in the presence of albumin using both 1-photon excitation and two-photon excitation showed that albumin strongly enhance the emission from ASP+ and induce a shift of the emission maximum from 600 to 570 nm.	Aspartic Acid	205-209	albumin	Homo sapiens	85-92
35418808-8	2022	Fluorescence emission spectra recorded in vitro of ASP+ alone and in the presence of albumin using both 1-photon excitation and two-photon excitation showed that albumin strongly enhance the emission from ASP+ and induce a shift of the emission maximum from 600 to 570 nm.	Aspartic Acid	205-209	albumin	Homo sapiens	162-169
35418808-10	2022	The renal pattern of fluorescence observed from ASP+ in vivo is likely affected by the local concentration of albumin, and quantification of ASP+ fluorescent signals in vivo cannot be directly translated to ASP+ concentrations.	Aspartic Acid	48-52	albumin	Homo sapiens	110-117
35133975-7	2022	PO induced accumulation of glycolytic metabolites, including L-serine, L-aspartate, and malate, in a YAP-dependent manner, thereby promoting cardiac hypertrophy.	Aspartic Acid	71-82	yes-associated protein 1	Mus musculus	101-104
35188507-6	2022	One of the most prevalent and difficult-to-identify modifications is that of aspartic acid between its four isomeric forms: L-Asp, L-isoAsp, D-Asp, and D-isoAsp.	Aspartic Acid	77-90	assembly factor for spindle microtubules	Homo sapiens	126-129
35188507-6	2022	One of the most prevalent and difficult-to-identify modifications is that of aspartic acid between its four isomeric forms: L-Asp, L-isoAsp, D-Asp, and D-isoAsp.	Aspartic Acid	77-90	assembly factor for spindle microtubules	Homo sapiens	143-146
35387260-3	2022	Specifically, ASP-835 (D835F/H/V/Y) mutant within the activation loop of FLT3 is the most commonly encountered drug-resistant and observed secondary FLT3 mutations.	Aspartic Acid	14-17	fms related receptor tyrosine kinase 3	Homo sapiens	73-77
35387260-3	2022	Specifically, ASP-835 (D835F/H/V/Y) mutant within the activation loop of FLT3 is the most commonly encountered drug-resistant and observed secondary FLT3 mutations.	Aspartic Acid	14-17	fms related receptor tyrosine kinase 3	Homo sapiens	149-153
35191674-0	2022	Aspartic Acid-Assisted Size-Controllable Synthesis of Nanoscale Spherical Covalent Organic Frameworks with Chiral Interfaces for Inhibiting Amyloid-beta Fibrillation.	Aspartic Acid	0-13	amyloid beta precursor protein	Homo sapiens	140-152
35342430-3	2022	In this study, we prepared decellularized porcine pericardium (DPP) scaffolds by the phospholipase A2 method and crosslinked them with aspartic acid (Asp) and human endothelial growth factor (hEGF) to enhance biological performance on the DPP, obtaining DPP-Asp-hEGF scaffolds.	Aspartic Acid	150-153	epidermal growth factor	Homo sapiens	192-196
35258781-9	2022	Moreover, RSV exhibited good binding affinity towards SphK1, with docking scores of -8.1 kcal/moL and formed hydrogen bonds with ASP-178 and LEU-268 in SphK1.	Aspartic Acid	129-132	sphingosine kinase 1	Rattus norvegicus	152-157
35090891-11	2022	We propose a novel and detailed mechanism by which the two His-Met-Asp residues of hCTR1 amino-terminus not only bind copper, but also maintain its reduced state crucial for intracellular uptake.	Aspartic Acid	67-70	solute carrier family 31 member 1	Homo sapiens	83-88
35090891-4	2022	Here we show that the extracellular amino-terminus of human CTR1 contains two methionine-histidine clusters and neighbouring aspartates that distinctly bind Cu(I) and Cu(II) preceding its import.	Aspartic Acid	125-135	solute carrier family 31 member 1	Homo sapiens	60-64
35090891-6	2022	We demonstrate the transient binding of both Cu(II) and Cu(I) during the reduction process is facilitated by aspartates that also act as another crucial determinant of hCTR1 endocytosis.	Aspartic Acid	109-119	solute carrier family 31 member 1	Homo sapiens	168-173
35113558-4	2022	The succinimide intermediate formed during reaction of l-isoAsp-containing peptides with PIMT and S-adenosyl methionine (SAM) is reactive with Tris base and results in a Tris-modified aspartic acid residue with a mass shift of +103 Da.	Aspartic Acid	184-197	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	89-93
35120923-6	2022	Furthermore, Cx50 levels as detected by immunoblotting were lower in Cx50S258F and Cx50S259Y mutants than in the wild type or the aspartate substitution mutants, and chloroquine or ammonium chloride treatment significantly increased Cx50S258F and Cx50S259Y protein levels, implying participation of the lysosome in their increased degradation.	Aspartic Acid	130-139	gap junction protein alpha 8	Homo sapiens	13-17
34989544-4	2022	We show that Met, Thr, Thr, Val, and Asp in the respective -1, +1, +2, +3, and +5 positions within the peptide substrate are favored for binding to the SOCS1-SH2 domain and identifying several phosphotyrosine peptides that have potent SOCS1 binding affinity with IC50 values ranging from 20 to 70 nM and greater than 100-fold selectivity against the closely related SOCS family proteins, CIS, SOCS2, and SOCS3.	Aspartic Acid	37-40	suppressor of cytokine signaling 1	Homo sapiens	235-240
35262078-4	2022	A structural model reproducibly predicted a binding mode where the pyrrolo pyrimidine forms a hydrogen bonding network with Asp 22 and the amide backbone NH of Ile 23 in the adenosine binding pocket and the carboxylate forms hydrogen bonds to the amide backbone of Phe 157 and Asp 156 , part of the oxyanion subsite of Mac1.	Aspartic Acid	124-127	integrin subunit alpha M	Homo sapiens	319-323
35019687-5	2022	Mutational analysis identifies 12 caspase cleavage sites in Sp3, which are situated at the aspartate (D) positions D17, D19, D180, D273, D275, D293, D304 (or D307), D326, D344, D530, D543, and D565.	Aspartic Acid	91-100	Sp3 transcription factor	Homo sapiens	60-63
35090891-10	2022	Finally, we show that two N-terminal His-Met-Asp clusters exhibit functional complementarity, as the second cluster is sufficient to preserve copper-induced CTR1 endocytosis upon complete deletion of the first cluster.	Aspartic Acid	45-48	solute carrier family 31 member 1	Homo sapiens	157-161
35281082-1	2022	Caspases are a family of cysteine proteases that predominantly cleave their substrates after aspartic acid residues.	Aspartic Acid	93-106	caspase 2	Homo sapiens	0-8
35218948-11	2022	Functional rescue assays further demonstrated that protein kinase B (AKT) activation, as well as reduced CCAAT enhancer-binding protein beta (C/EBPbeta) and increased CBP/p300-interacting transactivators with E (glutamic acid)/D (aspartic acid)-rich-carboxylterminal domain 4 (CITED4), contributed to the promotive effect of LEC-conditioned medium on cardiomyocyte hypertrophy and proliferation.	Aspartic Acid	230-243	protein tyrosine kinase 2 beta	Homo sapiens	51-67
35218948-11	2022	Functional rescue assays further demonstrated that protein kinase B (AKT) activation, as well as reduced CCAAT enhancer-binding protein beta (C/EBPbeta) and increased CBP/p300-interacting transactivators with E (glutamic acid)/D (aspartic acid)-rich-carboxylterminal domain 4 (CITED4), contributed to the promotive effect of LEC-conditioned medium on cardiomyocyte hypertrophy and proliferation.	Aspartic Acid	230-243	AKT serine/threonine kinase 1	Homo sapiens	69-72
35218948-11	2022	Functional rescue assays further demonstrated that protein kinase B (AKT) activation, as well as reduced CCAAT enhancer-binding protein beta (C/EBPbeta) and increased CBP/p300-interacting transactivators with E (glutamic acid)/D (aspartic acid)-rich-carboxylterminal domain 4 (CITED4), contributed to the promotive effect of LEC-conditioned medium on cardiomyocyte hypertrophy and proliferation.	Aspartic Acid	230-243	CREB binding protein	Homo sapiens	167-171
35218948-11	2022	Functional rescue assays further demonstrated that protein kinase B (AKT) activation, as well as reduced CCAAT enhancer-binding protein beta (C/EBPbeta) and increased CBP/p300-interacting transactivators with E (glutamic acid)/D (aspartic acid)-rich-carboxylterminal domain 4 (CITED4), contributed to the promotive effect of LEC-conditioned medium on cardiomyocyte hypertrophy and proliferation.	Aspartic Acid	230-243	E1A binding protein p300	Homo sapiens	171-175
34989544-4	2022	We show that Met, Thr, Thr, Val, and Asp in the respective -1, +1, +2, +3, and +5 positions within the peptide substrate are favored for binding to the SOCS1-SH2 domain and identifying several phosphotyrosine peptides that have potent SOCS1 binding affinity with IC50 values ranging from 20 to 70 nM and greater than 100-fold selectivity against the closely related SOCS family proteins, CIS, SOCS2, and SOCS3.	Aspartic Acid	37-40	suppressor of cytokine signaling 1	Homo sapiens	152-157
34989544-4	2022	We show that Met, Thr, Thr, Val, and Asp in the respective -1, +1, +2, +3, and +5 positions within the peptide substrate are favored for binding to the SOCS1-SH2 domain and identifying several phosphotyrosine peptides that have potent SOCS1 binding affinity with IC50 values ranging from 20 to 70 nM and greater than 100-fold selectivity against the closely related SOCS family proteins, CIS, SOCS2, and SOCS3.	Aspartic Acid	37-40	cytokine inducible SH2 containing protein	Homo sapiens	388-391
34989544-4	2022	We show that Met, Thr, Thr, Val, and Asp in the respective -1, +1, +2, +3, and +5 positions within the peptide substrate are favored for binding to the SOCS1-SH2 domain and identifying several phosphotyrosine peptides that have potent SOCS1 binding affinity with IC50 values ranging from 20 to 70 nM and greater than 100-fold selectivity against the closely related SOCS family proteins, CIS, SOCS2, and SOCS3.	Aspartic Acid	37-40	suppressor of cytokine signaling 2	Homo sapiens	393-398
34989544-4	2022	We show that Met, Thr, Thr, Val, and Asp in the respective -1, +1, +2, +3, and +5 positions within the peptide substrate are favored for binding to the SOCS1-SH2 domain and identifying several phosphotyrosine peptides that have potent SOCS1 binding affinity with IC50 values ranging from 20 to 70 nM and greater than 100-fold selectivity against the closely related SOCS family proteins, CIS, SOCS2, and SOCS3.	Aspartic Acid	37-40	suppressor of cytokine signaling 3	Homo sapiens	404-409
35076225-5	2022	The mechanistic underpinning permitted the identification of an optimized aspartate-reactive GAPDH inhibitor.	Aspartic Acid	74-83	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	93-98
35209187-6	2022	In particular, GOT1 reacted ~106-fold less efficiently when the side-chain carboxylate of the "physiological" substrates (aspartate and glutamate) was replaced by an amido group (asparagine and glutamine).	Aspartic Acid	122-131	glutamic-oxaloacetic transaminase 1	Homo sapiens	15-19
35181734-2	2022	One such gene, tryptophan-aspartate repeat domain 72 (WDR72), has been found to cause a tooth enamel defect when deleted or mutated, resulting in a condition called amelogenesis imperfecta.	Aspartic Acid	26-35	WD repeat domain 72	Homo sapiens	54-59
34996645-7	2022	Both campylobacters and ESBL-E. coli utilized aspartate, serine, formate, a-ketoglutarate and malate.	Aspartic Acid	46-55	EsbL	Escherichia coli	24-28
35177655-8	2022	Heterozygous pathogenic COL4A3 and COL4A4 variants that resulted in a Gly substitution with a highly destabilising residue (Arg, Val, Glu, Asp, Trp) were associated with an increased risk of haematuria (p = 0.018), and those adjacent to a non-collagenous region were associated with a reduced risk (p = 0.046).	Aspartic Acid	139-142	collagen type IV alpha 3 chain	Homo sapiens	24-30
35177655-8	2022	Heterozygous pathogenic COL4A3 and COL4A4 variants that resulted in a Gly substitution with a highly destabilising residue (Arg, Val, Glu, Asp, Trp) were associated with an increased risk of haematuria (p = 0.018), and those adjacent to a non-collagenous region were associated with a reduced risk (p = 0.046).	Aspartic Acid	139-142	collagen type IV alpha 4 chain	Homo sapiens	35-41
35174151-14	2022	Conclusion: Differential expression profile of three aspartic acid metabolic-associated genes, ASNS, CEBPA, and CAD, can be considered as a risk model with a good evaluation effect on the prognosis of colon cancer patients.	Aspartic Acid	53-66	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	95-99
35174151-14	2022	Conclusion: Differential expression profile of three aspartic acid metabolic-associated genes, ASNS, CEBPA, and CAD, can be considered as a risk model with a good evaluation effect on the prognosis of colon cancer patients.	Aspartic Acid	53-66	CCAAT enhancer binding protein alpha	Homo sapiens	101-106
35174151-14	2022	Conclusion: Differential expression profile of three aspartic acid metabolic-associated genes, ASNS, CEBPA, and CAD, can be considered as a risk model with a good evaluation effect on the prognosis of colon cancer patients.	Aspartic Acid	53-66	aconitate decarboxylase 1	Homo sapiens	112-115
35047152-9	2022	The expression of cyclin D1 and ss-catenin showed a considerable rise over the course of ASP induced osteogenesis.	Aspartic Acid	89-92	cyclin D1	Rattus norvegicus	18-27
35118070-1	2021	The asparaginase and isoaspartyl peptidase 1 (ASRGL1) is an L-asparaginase and beta-aspartyl peptidase enzyme that may be involved in the formation of L-aspartate, a neurotransmitter that can operate as an excitatory neurotransmitter in some brain regions.	Aspartic Acid	151-162	asparaginase	Mus musculus	4-44
35118070-1	2021	The asparaginase and isoaspartyl peptidase 1 (ASRGL1) is an L-asparaginase and beta-aspartyl peptidase enzyme that may be involved in the formation of L-aspartate, a neurotransmitter that can operate as an excitatory neurotransmitter in some brain regions.	Aspartic Acid	151-162	asparaginase like 1	Mus musculus	46-52
35118070-1	2021	The asparaginase and isoaspartyl peptidase 1 (ASRGL1) is an L-asparaginase and beta-aspartyl peptidase enzyme that may be involved in the formation of L-aspartate, a neurotransmitter that can operate as an excitatory neurotransmitter in some brain regions.	Aspartic Acid	151-162	asparaginase	Mus musculus	62-74
35118070-1	2021	The asparaginase and isoaspartyl peptidase 1 (ASRGL1) is an L-asparaginase and beta-aspartyl peptidase enzyme that may be involved in the formation of L-aspartate, a neurotransmitter that can operate as an excitatory neurotransmitter in some brain regions.	Aspartic Acid	151-162	asparaginase like 1	Mus musculus	79-102
35008954-1	2022	AGC1/Aralar/Slc25a12 is the mitochondrial carrier of aspartate-glutamate, the regulatory component of the NADH malate-aspartate shuttle (MAS) that transfers cytosolic redox power to neuronal mitochondria.	Aspartic Acid	118-127	solute carrier family 25 member 12	Homo sapiens	0-4
35008954-1	2022	AGC1/Aralar/Slc25a12 is the mitochondrial carrier of aspartate-glutamate, the regulatory component of the NADH malate-aspartate shuttle (MAS) that transfers cytosolic redox power to neuronal mitochondria.	Aspartic Acid	118-127	solute carrier family 25 member 12	Homo sapiens	5-11
35008954-1	2022	AGC1/Aralar/Slc25a12 is the mitochondrial carrier of aspartate-glutamate, the regulatory component of the NADH malate-aspartate shuttle (MAS) that transfers cytosolic redox power to neuronal mitochondria.	Aspartic Acid	118-127	solute carrier family 25 member 12	Homo sapiens	12-20
35008954-2	2022	The deficiency in AGC1/Aralar leads to the human rare disease named "early infantile epileptic encephalopathy 39" (EIEE 39, OMIM # 612949) characterized by epilepsy, hypotonia, arrested psychomotor neurodevelopment, hypo myelination and a drastic drop in brain aspartate (Asp) and N-acetylaspartate (NAA).	Aspartic Acid	261-270	solute carrier family 25 member 12	Homo sapiens	18-22
35008954-2	2022	The deficiency in AGC1/Aralar leads to the human rare disease named "early infantile epileptic encephalopathy 39" (EIEE 39, OMIM # 612949) characterized by epilepsy, hypotonia, arrested psychomotor neurodevelopment, hypo myelination and a drastic drop in brain aspartate (Asp) and N-acetylaspartate (NAA).	Aspartic Acid	261-270	solute carrier family 25 member 12	Homo sapiens	23-29
35008954-2	2022	The deficiency in AGC1/Aralar leads to the human rare disease named "early infantile epileptic encephalopathy 39" (EIEE 39, OMIM # 612949) characterized by epilepsy, hypotonia, arrested psychomotor neurodevelopment, hypo myelination and a drastic drop in brain aspartate (Asp) and N-acetylaspartate (NAA).	Aspartic Acid	272-275	solute carrier family 25 member 12	Homo sapiens	18-22
35008954-2	2022	The deficiency in AGC1/Aralar leads to the human rare disease named "early infantile epileptic encephalopathy 39" (EIEE 39, OMIM # 612949) characterized by epilepsy, hypotonia, arrested psychomotor neurodevelopment, hypo myelination and a drastic drop in brain aspartate (Asp) and N-acetylaspartate (NAA).	Aspartic Acid	272-275	solute carrier family 25 member 12	Homo sapiens	23-29
35008954-5	2022	Herein, we discuss the role of the AGC1/Aralar-MAS pathway in neuronal functions such as Asp and NAA synthesis, lactate use, respiration on glucose, glutamate (Glu) oxidation and other neurometabolic aspects.	Aspartic Acid	89-92	solute carrier family 25 member 12	Homo sapiens	35-39
35058562-5	2022	We identified citrin, a well-defined Ca2+-binding component of malate-aspartate shuttle in the mitochondrial intermembrane space, as predominant target of this basal Ca2+ regulation.	Aspartic Acid	70-79	solute carrier family 25 member 13	Homo sapiens	14-20
34978431-5	2022	TM binding causes reduced H/D exchange in these regions and also alters the dynamics of the beta-strand that links the TM binding site to the catalytic Asp 102 in both wild type thrombin and in the W215A/E217A mutant thrombin.	Aspartic Acid	152-155	coagulation factor II, thrombin	Homo sapiens	178-186
35162943-0	2022	Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate.	Aspartic Acid	94-103	Ucp4A	Drosophila melanogaster	24-45
35162943-0	2022	Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate.	Aspartic Acid	94-103	Ucp4A	Drosophila melanogaster	47-52
35162943-5	2022	Here, we show that DmUCP4A expressed in bacteria and reconstituted in phospholipid vesicles catalyzes a unidirectional transport of aspartate, which is saturable and inhibited by mercurials and other mitochondrial carrier inhibitors to various degrees.	Aspartic Acid	132-141	Ucp4A	Drosophila melanogaster	19-26
35162943-7	2022	The biochemical function of DmUCP4A has been further confirmed in a yeast cell model, in which growth has required an efflux of aspartate from mitochondria.	Aspartic Acid	128-137	Ucp4A	Drosophila melanogaster	28-35
35162943-9	2022	In Drosophila melanogaster, DmUCP4A could be involved in the transport of aspartate from mitochondria to the cytosol, in which it could be used for protein and nucleotide synthesis, as well as in the biosynthesis of ss-alanine and N-acetylaspartate, which play key roles in signal transmission in the central nervous system.	Aspartic Acid	74-83	Ucp4A	Drosophila melanogaster	28-35
34983389-7	2022	Conversely, mbk-1 dependent expression patterns of selected pathogen resistance genes, including asp-12, dod-24 and drd-50, differed across the genetic backgrounds examined.	Aspartic Acid	97-100	Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1	Caenorhabditis elegans	12-17
35008954-1	2022	AGC1/Aralar/Slc25a12 is the mitochondrial carrier of aspartate-glutamate, the regulatory component of the NADH malate-aspartate shuttle (MAS) that transfers cytosolic redox power to neuronal mitochondria.	Aspartic Acid	53-62	solute carrier family 25 member 12	Homo sapiens	0-4
35008954-1	2022	AGC1/Aralar/Slc25a12 is the mitochondrial carrier of aspartate-glutamate, the regulatory component of the NADH malate-aspartate shuttle (MAS) that transfers cytosolic redox power to neuronal mitochondria.	Aspartic Acid	53-62	solute carrier family 25 member 12	Homo sapiens	5-11
35008954-1	2022	AGC1/Aralar/Slc25a12 is the mitochondrial carrier of aspartate-glutamate, the regulatory component of the NADH malate-aspartate shuttle (MAS) that transfers cytosolic redox power to neuronal mitochondria.	Aspartic Acid	53-62	solute carrier family 25 member 12	Homo sapiens	12-20
35047152-10	2022	Dickkopf 1 (DKK1) suppressed the regulation of rat BMSCs differentiation through the mediation of ASP.	Aspartic Acid	98-101	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	0-10
35047152-10	2022	Dickkopf 1 (DKK1) suppressed the regulation of rat BMSCs differentiation through the mediation of ASP.	Aspartic Acid	98-101	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	12-16
35491020-4	2022	Complexation of ConA and CD206 with ligands is shown to be energetically caused by electrostatic interactions (E) of the charged residues (Asn, Asp, Arg) with oxygen and hydrogen atoms in carbohydrates; contributions of hydrophobic and van der Waals components is lower.	Aspartic Acid	144-147	mannose receptor C-type 1	Homo sapiens	25-30
35444834-6	2022	(2021) demonstrate that mitochondrial function is impaired in CD4+ T cells from RA patients, leading to reduced levels of various citric acid cycle metabolites (e.g., aspartate) that regulate TNF-alpha production.	Aspartic Acid	167-176	CD4 molecule	Homo sapiens	62-65
35444834-6	2022	(2021) demonstrate that mitochondrial function is impaired in CD4+ T cells from RA patients, leading to reduced levels of various citric acid cycle metabolites (e.g., aspartate) that regulate TNF-alpha production.	Aspartic Acid	167-176	tumor necrosis factor	Homo sapiens	192-201