PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33575850-11	2021	By contrast, a toxicokinetic interaction was identified including an inhibition of the metabolic enzyme CYP3A4 by fludioxonil and a decreased metabolic conversion of the CYP3A4 substrate difenoconazole when used in mixture experiments.	difenoconazole	187-201	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	170-176
29096293-1	2018	Difenoconazole, a typical triazole fungicide, inhibits lanosterol-14R-demethylase (CYP51) to prevent fungal sterol synthesis and its residues are frequently detected in the environment due to its wide application.	difenoconazole	0-14	cytochrome P450, family 51	Danio rerio	83-88
32729807-0	2021	Difenoconazole Resistance Shift in Botrytis cinerea from Tomato in China Associated with Inducible Expression of CYP51.	difenoconazole	0-14	sterol C14-demetylase	Solanum lycopersicum	113-118
31877229-8	2020	Interestingly, the AMPK activator AICAR, the autophagy inducer rapamycin and the demethylation inhibitor difenoconazole negated CD74 ablation-offered benefit against LPS-induced cardiac dysfunction while the SUV39H1 inhibitor chaetocin or methylation inhibitor 5-AzaC ameliorated LPS-induced GFP-LC3B formation and cardiomyocyte contractile dysfunction.	difenoconazole	105-119	CD74 molecule	Homo sapiens	128-132
31877229-8	2020	Interestingly, the AMPK activator AICAR, the autophagy inducer rapamycin and the demethylation inhibitor difenoconazole negated CD74 ablation-offered benefit against LPS-induced cardiac dysfunction while the SUV39H1 inhibitor chaetocin or methylation inhibitor 5-AzaC ameliorated LPS-induced GFP-LC3B formation and cardiomyocyte contractile dysfunction.	difenoconazole	105-119	SUV39H1 histone lysine methyltransferase	Homo sapiens	208-215
31877229-8	2020	Interestingly, the AMPK activator AICAR, the autophagy inducer rapamycin and the demethylation inhibitor difenoconazole negated CD74 ablation-offered benefit against LPS-induced cardiac dysfunction while the SUV39H1 inhibitor chaetocin or methylation inhibitor 5-AzaC ameliorated LPS-induced GFP-LC3B formation and cardiomyocyte contractile dysfunction.	difenoconazole	105-119	microtubule associated protein 1 light chain 3 beta	Homo sapiens	296-300
31482525-8	2019	The difenoconazole was detected in concentrations between 12.53 and 94.76 ng L-1.	difenoconazole	4-18	L1 cell adhesion molecule	Homo sapiens	77-80
31024507-15	2019	Among agricultural fungicides, difenoconazole had the lowest activity against FSSC with MICs of >32 mug mL-1 for all isolates.	difenoconazole	31-45	2'-5' oligoadenylate synthetase 1B	Mus musculus	107-111
29096293-6	2018	RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3beta, hsd11beta, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and eralpha genes in livers.	difenoconazole	42-56	luteinizing hormone/choriogonadotropin receptor	Danio rerio	104-107
29096293-6	2018	RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3beta, hsd11beta, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and eralpha genes in livers.	difenoconazole	42-56	hydroxy-delta-5-steroid dehydrogenase, 3 beta	Danio rerio	109-117
29096293-6	2018	RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3beta, hsd11beta, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and eralpha genes in livers.	difenoconazole	42-56	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	130-136
29096293-6	2018	RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3beta, hsd11beta, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and eralpha genes in livers.	difenoconazole	42-56	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	160-166
29096293-6	2018	RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3beta, hsd11beta, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and eralpha genes in livers.	difenoconazole	42-56	cytochrome P450, family 3, subfamily c, polypeptide 1	Danio rerio	168-174
29096293-6	2018	RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3beta, hsd11beta, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and eralpha genes in livers.	difenoconazole	42-56	estrogen receptor 1	Danio rerio	194-201
34877763-8	2022	In addition, DFC can induce the release of Cyt c, promote the collapse of mitochondrial membrane potential and increase the Bax/Bcl-2 ratio in RAW264.7 cells.	difenoconazole	13-16	BCL2-associated X protein	Mus musculus	124-127
28679351-6	2018	Difenoconazole increased the levels of malondialdehyde (MDA) and advanced oxidation protein products (AOPPs), and decreased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and vitamin C levels in liver tissues compared to the control group.	difenoconazole	0-14	catalase	Rattus norvegicus	152-160
28679351-6	2018	Difenoconazole increased the levels of malondialdehyde (MDA) and advanced oxidation protein products (AOPPs), and decreased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and vitamin C levels in liver tissues compared to the control group.	difenoconazole	0-14	catalase	Rattus norvegicus	162-165
24534568-0	2014	An in situ immobilized pipette tip solid phase microextraction method based on molecularly imprinted polymer monolith for the selective determination of difenoconazole in tap water and grape juice.	difenoconazole	153-167	nuclear RNA export factor 1	Homo sapiens	171-174
24534568-1	2014	A pipette tip-based molecularly imprinted polymer monolith microextraction (PT-MIPMME) method was developed for the selective extraction of difenoconazole in tap water and grape juice.	difenoconazole	140-154	nuclear RNA export factor 1	Homo sapiens	158-161
24534568-8	2014	The results showed that difenoconazole was selectively enriched from tap water and grape juice samples.	difenoconazole	24-38	nuclear RNA export factor 1	Homo sapiens	69-72
24819020-8	2014	The method was successfully applied to the analysis of honey samples and difenoconazole was determined at ngg(-1) levels.	difenoconazole	73-87	transcriptional adaptor 3	Homo sapiens	106-112
12711008-6	2003	After stimulation of cells by DHT (10nM), synthetic androgen R1881 (1 nM), or organic pesticides (difenoconazole, fentinacetate, tetramethrin) TMPRSS2 mRNA expression was down-regulated by the factor 0.6 after 24h of DHT treatment.	difenoconazole	98-112	transmembrane serine protease 2	Homo sapiens	143-150
34877763-8	2022	In addition, DFC can induce the release of Cyt c, promote the collapse of mitochondrial membrane potential and increase the Bax/Bcl-2 ratio in RAW264.7 cells.	difenoconazole	13-16	B cell leukemia/lymphoma 2	Mus musculus	128-133
35487176-8	2022	In addition, we found that DFZ caused excessive apoptosis in spleen tissue by TUNEL staining and expression levels of apoptosis-related genes (caspase3, caspase8, caspase9, fas, bax, bcl-2, and p53).	difenoconazole	27-30	tumor necrosis factor receptor superfamily member 6	Cyprinus carpio	173-176
34139443-6	2021	Further studies showed that Difenoconazole induced DNA double-strand breaks, intracellular generation of ROS, cleaved PARP, mitochondrial membrane potential collapse, induced Cyt c release, and Bax/Bcl-2 ratio increase in SH-SY5Y cells.	difenoconazole	28-42	collagen type XI alpha 2 chain	Homo sapiens	118-122
34139443-6	2021	Further studies showed that Difenoconazole induced DNA double-strand breaks, intracellular generation of ROS, cleaved PARP, mitochondrial membrane potential collapse, induced Cyt c release, and Bax/Bcl-2 ratio increase in SH-SY5Y cells.	difenoconazole	28-42	BCL2 associated X, apoptosis regulator	Homo sapiens	194-197
34139443-6	2021	Further studies showed that Difenoconazole induced DNA double-strand breaks, intracellular generation of ROS, cleaved PARP, mitochondrial membrane potential collapse, induced Cyt c release, and Bax/Bcl-2 ratio increase in SH-SY5Y cells.	difenoconazole	28-42	BCL2 apoptosis regulator	Homo sapiens	198-203
34834667-7	2021	Difenoconazole exposure also induced the activities of superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (G-POD), and ascorbate peroxidase (APX) in the roots and leaves of the wheat seedlings.	difenoconazole	0-14	SOD	Triticum aestivum	55-75
34834667-7	2021	Difenoconazole exposure also induced the activities of superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (G-POD), and ascorbate peroxidase (APX) in the roots and leaves of the wheat seedlings.	difenoconazole	0-14	SOD	Triticum aestivum	77-80
34834667-7	2021	Difenoconazole exposure also induced the activities of superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (G-POD), and ascorbate peroxidase (APX) in the roots and leaves of the wheat seedlings.	difenoconazole	0-14	catalase-1	Triticum aestivum	83-91
34834667-7	2021	Difenoconazole exposure also induced the activities of superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (G-POD), and ascorbate peroxidase (APX) in the roots and leaves of the wheat seedlings.	difenoconazole	0-14	catalase-1	Triticum aestivum	93-96
34834667-7	2021	Difenoconazole exposure also induced the activities of superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (G-POD), and ascorbate peroxidase (APX) in the roots and leaves of the wheat seedlings.	difenoconazole	0-14	POD1	Triticum aestivum	132-152
34834667-7	2021	Difenoconazole exposure also induced the activities of superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (G-POD), and ascorbate peroxidase (APX) in the roots and leaves of the wheat seedlings.	difenoconazole	0-14	POD1	Triticum aestivum	154-157
35121040-5	2022	Furthermore, three common pesticides, prochloraz (PCZ), difenoconazole (DFZ) and chlorothalonil (CTL), could significantly inhibit CYP3A-mediated DMM metabolism, and consequently trigger elevated exposure to DMM in vivo.	difenoconazole	56-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-136
35121040-5	2022	Furthermore, three common pesticides, prochloraz (PCZ), difenoconazole (DFZ) and chlorothalonil (CTL), could significantly inhibit CYP3A-mediated DMM metabolism, and consequently trigger elevated exposure to DMM in vivo.	difenoconazole	72-75	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-136
35357135-8	2022	Molecular simulation docking results of compound D26 and difenoconazole with fungal CYP51 P450 confirmed that they both inhibit this enzyme involved in ergosterol biosynthesis.	difenoconazole	57-71	CYTOCHROME P450 51G1	Arabidopsis thaliana	84-89
35051076-6	2022	The transcript levels of mucin protein (muc1, muc2 and muc3) decreased significantly in the gut of mice followed 56 days of 100 mg/kg/day DIF exposure.	difenoconazole	138-141	mucin 1, transmembrane	Mus musculus	40-44
35051076-6	2022	The transcript levels of mucin protein (muc1, muc2 and muc3) decreased significantly in the gut of mice followed 56 days of 100 mg/kg/day DIF exposure.	difenoconazole	138-141	mucin 2	Mus musculus	46-50
35051076-6	2022	The transcript levels of mucin protein (muc1, muc2 and muc3) decreased significantly in the gut of mice followed 56 days of 100 mg/kg/day DIF exposure.	difenoconazole	138-141	mucin 3, intestinal	Mus musculus	55-59
35051076-13	2022	Meanwhile, the alpha diversity indexes, including observed species, Shannon, Simpson, Chao1 and ACE, in gut microbiota decreased significantly after 56 days of DIF exposure.	difenoconazole	160-163	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	96-99