PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34000310-5 2021 The addition of NCF at 1.5% weight of starch increased the tensile strength (TS) and Young"s Modulus (YM), but decreased the elongation at break (EAB), oxygen permeability, and water vapor permeability of the CS films. Oxygen 152-158 neutrophil cytosolic factor 4 Homo sapiens 16-19 4044034-1 1985 C-reactive protein (CRP), an acute-phase reactant which binds to phosphocholine (PC) in the pneumococcal cell wall, and anti-PC antibodies are protective against experimental pneumococcal bacteremia in mice. Phosphorylcholine 81-83 C-reactive protein, pentraxin-related Mus musculus 0-18 4044034-1 1985 C-reactive protein (CRP), an acute-phase reactant which binds to phosphocholine (PC) in the pneumococcal cell wall, and anti-PC antibodies are protective against experimental pneumococcal bacteremia in mice. Phosphorylcholine 81-83 C-reactive protein, pentraxin-related Mus musculus 20-23 3996599-4 1985 A reduction of the (E) parameter from 1.227 to 1.135 GHz is postulated to result from Stark effects caused by the binding of a polar group (possibly phosphocholine) near Trp3 in the PA2-C16PN micelle complex. Phosphorylcholine 149-163 tRNA-Pro (anticodon TGG) 3-1 Homo sapiens 170-174 2412834-1 1985 A cDNA library of phosphorylcholine (PC)-specific suppressor T hybridoma, 29-C-6, was constructed. Phosphorylcholine 18-35 complement C6 Homo sapiens 77-80 2412834-1 1985 A cDNA library of phosphorylcholine (PC)-specific suppressor T hybridoma, 29-C-6, was constructed. Phosphorylcholine 37-39 complement C6 Homo sapiens 77-80 3996599-4 1985 A reduction of the (E) parameter from 1.227 to 1.135 GHz is postulated to result from Stark effects caused by the binding of a polar group (possibly phosphocholine) near Trp3 in the PA2-C16PN micelle complex. Phosphorylcholine 149-163 phospholipase A2 group IB Homo sapiens 182-185 3964816-1 1985 Monoclonal antibody NL16, prepared with phosphorylcholine (PC)-binding myeloma protein C.BBPC3 (C3), identified an idiotope (C3-16 Id) that was present on T15 IdX+ myeloma proteins (MP) C3, T15, and H8, but not the T15 IdX- MP M167 and M603. Phosphorylcholine 40-57 complement component 3 Mus musculus 87-94 4084018-2 1985 CRP was purified using 4-step procedure including absorption on Sepharose 4B, phosphocholine-Sepharose, DE-52 ion exchange chromatography and gel filtration on Sephacryl S-200. Phosphorylcholine 78-92 C-reactive protein Homo sapiens 0-3 3919022-2 1985 CRP of all species binds to phosphorylcholine residues. Phosphorylcholine 28-45 C-reactive protein Homo sapiens 0-3 3964816-1 1985 Monoclonal antibody NL16, prepared with phosphorylcholine (PC)-binding myeloma protein C.BBPC3 (C3), identified an idiotope (C3-16 Id) that was present on T15 IdX+ myeloma proteins (MP) C3, T15, and H8, but not the T15 IdX- MP M167 and M603. Phosphorylcholine 59-61 complement component 3 Mus musculus 87-94 3155460-2 1985 Genes unlinked to the Igh locus regulate T15 dominance of the secondary adoptive transfer response to phosphocholine. Phosphorylcholine 102-116 immunoglobulin heavy chain complex Mus musculus 22-25 3964816-2 1985 The binding of C3 to NL16 is PC inhibitable, indicating that C3-16 Id is site associated. Phosphorylcholine 29-31 complement component 3 Mus musculus 15-17 6092541-8 1984 Ornithine decarboxylase activity from 7-day-old cerebellum was inhibited in a concentration-dependent manner by phosphorylcholine. Phosphorylcholine 112-129 ornithine decarboxylase 1 Rattus norvegicus 0-23 6238089-0 1984 Helper T lymphocytes from xid and normal mice support anti-phosphocholine antibody responses with equivalent T15, 511, and 603 idiotypic composition. Phosphorylcholine 59-73 Bruton agammaglobulinemia tyrosine kinase Mus musculus 26-29 6204002-0 1984 Interaction of helper T cells and Lyb5+ B cells responding to phosphorylcholine is MHC-restricted. Phosphorylcholine 62-79 B-lymphocyte antigen 5 Mus musculus 34-38 6088536-8 1984 Pulse-label and pulse-chase studies indicate that the conversion rate of phosphocholine to CDP-choline, catalyzed by CTP:phosphocholine cytidylyltransferase, is diminished by norepinephrine. Phosphorylcholine 73-87 cut-like homeobox 1 Rattus norvegicus 91-94 6088536-8 1984 Pulse-label and pulse-chase studies indicate that the conversion rate of phosphocholine to CDP-choline, catalyzed by CTP:phosphocholine cytidylyltransferase, is diminished by norepinephrine. Phosphorylcholine 73-87 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 117-156 6427230-3 1984 Studies using 14C-labeled C-reactive protein show that binding to chromatin is saturable with a Kd = 8 X 10(-7) M, a value indicating that the affinity of C-reactive protein for chromatin is at least four times its affinity for phosphorylcholine. Phosphorylcholine 228-245 C-reactive protein like 1 Gallus gallus 26-44 6427230-3 1984 Studies using 14C-labeled C-reactive protein show that binding to chromatin is saturable with a Kd = 8 X 10(-7) M, a value indicating that the affinity of C-reactive protein for chromatin is at least four times its affinity for phosphorylcholine. Phosphorylcholine 228-245 C-reactive protein like 1 Gallus gallus 155-173 6427230-6 1984 Fifty per cent inhibition of the binding of C-reactive protein to phosphorylcholine is obtained at a core particle concentration of 1.25 X 10(-9) M, indicating that the affinity of C-reactive protein for one of the sites on core particles is at least 2400 times greater than the affinity of C-reactive protein for phosphorylcholine. Phosphorylcholine 66-83 C-reactive protein like 1 Gallus gallus 44-62 6427230-6 1984 Fifty per cent inhibition of the binding of C-reactive protein to phosphorylcholine is obtained at a core particle concentration of 1.25 X 10(-9) M, indicating that the affinity of C-reactive protein for one of the sites on core particles is at least 2400 times greater than the affinity of C-reactive protein for phosphorylcholine. Phosphorylcholine 66-83 C-reactive protein like 1 Gallus gallus 181-199 6427230-6 1984 Fifty per cent inhibition of the binding of C-reactive protein to phosphorylcholine is obtained at a core particle concentration of 1.25 X 10(-9) M, indicating that the affinity of C-reactive protein for one of the sites on core particles is at least 2400 times greater than the affinity of C-reactive protein for phosphorylcholine. Phosphorylcholine 66-83 C-reactive protein like 1 Gallus gallus 181-199 6427230-6 1984 Fifty per cent inhibition of the binding of C-reactive protein to phosphorylcholine is obtained at a core particle concentration of 1.25 X 10(-9) M, indicating that the affinity of C-reactive protein for one of the sites on core particles is at least 2400 times greater than the affinity of C-reactive protein for phosphorylcholine. Phosphorylcholine 314-331 C-reactive protein like 1 Gallus gallus 44-62 6427230-6 1984 Fifty per cent inhibition of the binding of C-reactive protein to phosphorylcholine is obtained at a core particle concentration of 1.25 X 10(-9) M, indicating that the affinity of C-reactive protein for one of the sites on core particles is at least 2400 times greater than the affinity of C-reactive protein for phosphorylcholine. Phosphorylcholine 314-331 C-reactive protein like 1 Gallus gallus 181-199 6427230-6 1984 Fifty per cent inhibition of the binding of C-reactive protein to phosphorylcholine is obtained at a core particle concentration of 1.25 X 10(-9) M, indicating that the affinity of C-reactive protein for one of the sites on core particles is at least 2400 times greater than the affinity of C-reactive protein for phosphorylcholine. Phosphorylcholine 314-331 C-reactive protein like 1 Gallus gallus 181-199 6747291-2 1984 CRP reacts with the phosphocholine moiety of pneumococcal cell wall C-polysaccharide, and this reaction can lead to complement activation in vitro and protection against pneumococcal infection in vivo. Phosphorylcholine 20-34 C-reactive protein Homo sapiens 0-3 6743332-0 1984 Inhibition of ornithine decarboxylase and glutamic acid decarboxylase activities by phosphorylethanolamine and phosphorylcholine. Phosphorylcholine 111-128 ornithine decarboxylase 1 Homo sapiens 14-37 6743332-3 1984 The present study sought to determine the effect of phosphorylcholine, the product of the reaction catalyzed by choline kinase, on ornithine decarboxylase activity. Phosphorylcholine 52-69 ornithine decarboxylase 1 Homo sapiens 131-154 6743332-5 1984 The data demonstrate that ornithine decarboxylase activity is inhibited by phosphorylcholine and more potently by the related compound phosphorylethanolamine. Phosphorylcholine 75-92 ornithine decarboxylase 1 Homo sapiens 26-49 6642659-4 1983 Transport of C carbohydrate was significantly correlated with the level of naturally occurring IgA antibodies specific for the phosphocholine determinant, but not with IgM or IgG antibodies. Phosphorylcholine 127-141 CD79A antigen (immunoglobulin-associated alpha) Mus musculus 95-98 6363539-0 1984 Inhibition of antibody responses to phosphocholine by C-reactive protein. Phosphorylcholine 36-50 C-reactive protein, pentraxin-related Mus musculus 54-72 6363539-1 1984 C-reactive protein (CRP) is an acute phase serum protein in man that binds to the cell wall C-polysaccharide (PnC) of Streptococcus pneumoniae via phosphocholine (PC) determinants. Phosphorylcholine 147-161 C-reactive protein Homo sapiens 0-18 6363539-1 1984 C-reactive protein (CRP) is an acute phase serum protein in man that binds to the cell wall C-polysaccharide (PnC) of Streptococcus pneumoniae via phosphocholine (PC) determinants. Phosphorylcholine 147-161 C-reactive protein Homo sapiens 20-23 6363539-1 1984 C-reactive protein (CRP) is an acute phase serum protein in man that binds to the cell wall C-polysaccharide (PnC) of Streptococcus pneumoniae via phosphocholine (PC) determinants. Phosphorylcholine 163-165 C-reactive protein Homo sapiens 0-18 6363539-1 1984 C-reactive protein (CRP) is an acute phase serum protein in man that binds to the cell wall C-polysaccharide (PnC) of Streptococcus pneumoniae via phosphocholine (PC) determinants. Phosphorylcholine 163-165 C-reactive protein Homo sapiens 20-23 6361145-0 1983 A new sensitive assay for the calcium-dependent binding of C-reactive protein to phosphorylcholine. Phosphorylcholine 81-98 C-reactive protein Oryctolagus cuniculus 59-77 6361145-1 1983 A new sensitive assay for the calcium-dependent binding of rabbit C-reactive protein to phosphorylcholine has been developed. Phosphorylcholine 88-105 C-reactive protein Oryctolagus cuniculus 66-84 6361145-4 1983 The binding of rabbit C-reactive protein to the bovine serum albumin-phosphorylcholine conjugate is completely inhibited by free phosphorylcholine, by pneumococcal C-polysaccharide and by calcium chelators but not by high concentrations of neutral, cationic or zwitterionic detergents. Phosphorylcholine 69-86 C-reactive protein Oryctolagus cuniculus 22-40 6715371-4 1984 259, 5734-5739) was applied to the activation of phospholipase A2-catalyzed hydrolysis of a thiol ester analog of phosphatidylethanolamine (thio - PE) in Triton X - 100/phospholipid mixed micelles by various phosphorylcholine-containing activators. Phosphorylcholine 208-225 phospholipase A2 group IB Homo sapiens 49-65 6733593-1 1984 Substituents on the nitrogen atom of the phosphorylcholine moiety of natural C16 platelet-activating factor (PAF) were modified or replaced by more bulky groups, and their hypotensive activities were examined with rats. Phosphorylcholine 41-58 PCNA clamp associated factor Rattus norvegicus 81-107 6733593-1 1984 Substituents on the nitrogen atom of the phosphorylcholine moiety of natural C16 platelet-activating factor (PAF) were modified or replaced by more bulky groups, and their hypotensive activities were examined with rats. Phosphorylcholine 41-58 PCNA clamp associated factor Rattus norvegicus 109-112 6226742-0 1983 The asymmetry in idiotype-isotype expression in the response to phosphocholine is due to divergence in the expressed repertoires of Lyb-5+ and Lyb-5- B cells. Phosphorylcholine 64-78 B-lymphocyte antigen 5 Mus musculus 132-137 6195262-0 1983 Localization of the phosphocholine-binding sites on C-reactive protein by immunoelectron microscopy. Phosphorylcholine 20-34 C-reactive protein Homo sapiens 52-70 6226742-0 1983 The asymmetry in idiotype-isotype expression in the response to phosphocholine is due to divergence in the expressed repertoires of Lyb-5+ and Lyb-5- B cells. Phosphorylcholine 64-78 B-lymphocyte antigen 5 Mus musculus 143-148 6195262-1 1983 C-reactive protein (CRP) was reacted with monoclonal IgG antibody or Fab antibody fragments directed against the phosphocholine- (PC) binding site or a second unrelated site. Phosphorylcholine 113-127 C-reactive protein Homo sapiens 0-18 6226742-1 1983 The X-linked CBA/N immune defect was used to investigate the roles of Lyb-5- and Lyb-5+ B cells in the memory response to PC-KLH (phosphocholine-conjugated keyhole limpet hemocyanin). Phosphorylcholine 130-144 B-lymphocyte antigen 5 Mus musculus 81-86 6195262-1 1983 C-reactive protein (CRP) was reacted with monoclonal IgG antibody or Fab antibody fragments directed against the phosphocholine- (PC) binding site or a second unrelated site. Phosphorylcholine 113-127 C-reactive protein Homo sapiens 20-23 6195262-1 1983 C-reactive protein (CRP) was reacted with monoclonal IgG antibody or Fab antibody fragments directed against the phosphocholine- (PC) binding site or a second unrelated site. Phosphorylcholine 130-132 C-reactive protein Homo sapiens 0-18 6602170-0 1983 Contribution of Lyb 5+ and Lyb 5- B cells to the primary and secondary phosphocholine-specific antibody response. Phosphorylcholine 71-85 B-lymphocyte antigen 5 Mus musculus 16-21 6195262-1 1983 C-reactive protein (CRP) was reacted with monoclonal IgG antibody or Fab antibody fragments directed against the phosphocholine- (PC) binding site or a second unrelated site. Phosphorylcholine 130-132 C-reactive protein Homo sapiens 20-23 6195262-6 1983 Thus, the PC-binding site and the non-PC-binding site are oriented nearly perpendicular but on opposite sides with respect to the plane of the CRP molecule. Phosphorylcholine 10-12 C-reactive protein Homo sapiens 143-146 6195262-6 1983 Thus, the PC-binding site and the non-PC-binding site are oriented nearly perpendicular but on opposite sides with respect to the plane of the CRP molecule. Phosphorylcholine 38-40 C-reactive protein Homo sapiens 143-146 6656768-15 1983 In the absence of calcium, exposure to urea led to increased electrophoretic mobility and exposure of a new antigenic reactivity, and to alterations in the phosphocholine- but not the polycation-binding sites of the native CRP molecule; this new antigenic reactivity may be of value in further studies on the CRP molecule. Phosphorylcholine 156-170 C-reactive protein Homo sapiens 223-226 6602170-0 1983 Contribution of Lyb 5+ and Lyb 5- B cells to the primary and secondary phosphocholine-specific antibody response. Phosphorylcholine 71-85 B-lymphocyte antigen 5 Mus musculus 27-32 6877243-2 1983 CRP binds with phosphocholine and phosphate esters; initiates reactions of agglutination, opsonization and complement consumption; and precipitates with protamine and synthetic polymers of lysine and arginine, and these reactivities are modulated by calcium and phosphocholine. Phosphorylcholine 15-29 C-reactive protein Homo sapiens 0-3 6877243-2 1983 CRP binds with phosphocholine and phosphate esters; initiates reactions of agglutination, opsonization and complement consumption; and precipitates with protamine and synthetic polymers of lysine and arginine, and these reactivities are modulated by calcium and phosphocholine. Phosphorylcholine 262-276 C-reactive protein Homo sapiens 0-3 6856033-2 1983 CDP-choline is demonstrated to be rapidly hydrolysed into CMP and choline phosphate. Phosphorylcholine 66-83 cut like homeobox 1 Homo sapiens 0-3 6868019-6 1983 It appears that the correct stereochemistry and a phosphorylcholine group in a strictly defined position towards the asymmetric C-2 of the glycerol backbone are absolute requirements for activity whereas variations in the alkyl and the short chain acyl groups have not as dramatic consequences. Phosphorylcholine 50-67 complement C2 Homo sapiens 128-131 6885107-3 1983 C-reactive protein (CRP) is known to bind to molecules containing phosphocholine-substituents following reaction with Ca2+ ions. Phosphorylcholine 66-80 C-reactive protein Homo sapiens 0-18 6403520-6 1983 The dogfish C-reactive protein isolated by the phosphorylcholine affinity matrix precipitates with pneumococcal C-polysaccharide and with a synthetic derivative of bovine serum albumin to which phosphorylcholine is covalently attached. Phosphorylcholine 47-64 C-reactive protein Oryctolagus cuniculus 12-30 6403520-6 1983 The dogfish C-reactive protein isolated by the phosphorylcholine affinity matrix precipitates with pneumococcal C-polysaccharide and with a synthetic derivative of bovine serum albumin to which phosphorylcholine is covalently attached. Phosphorylcholine 194-211 C-reactive protein Oryctolagus cuniculus 12-30 6300060-10 1983 The dogfish C-reactive protein, which exists as a Mr = 50,000 dimer, bound 2 mol of the phosphorylcholine spin label per mol of protein, and this binding exhibited negative cooperativity as indicated by a Hill coefficient of 0.75. Phosphorylcholine 88-105 C-reactive protein Homo sapiens 12-30 6885107-3 1983 C-reactive protein (CRP) is known to bind to molecules containing phosphocholine-substituents following reaction with Ca2+ ions. Phosphorylcholine 66-80 C-reactive protein Homo sapiens 20-23 7086355-1 1982 C-reactive protein (CRP), the classical acute-phase protein, can bind phospholipids by virtue of its specific, calcium-dependent reactivity with phosphorylcholine residues. Phosphorylcholine 145-162 C-reactive protein Homo sapiens 0-18 6183579-2 1982 This Ca2+-dependent binding can be inhibited by 1.0 mM phosphocholine, indicating that this antigenic determinant is at or near the phosphocholine-binding site of C-reactive protein. Phosphorylcholine 55-69 C-reactive protein Oryctolagus cuniculus 163-181 6183579-2 1982 This Ca2+-dependent binding can be inhibited by 1.0 mM phosphocholine, indicating that this antigenic determinant is at or near the phosphocholine-binding site of C-reactive protein. Phosphorylcholine 132-146 C-reactive protein Oryctolagus cuniculus 163-181 6980926-0 1982 Antibodies from the Lyb-5- B cell subset predominate in the secondary IgG response to phosphocholine. Phosphorylcholine 86-100 B-lymphocyte antigen 5 Mus musculus 20-25 7086355-1 1982 C-reactive protein (CRP), the classical acute-phase protein, can bind phospholipids by virtue of its specific, calcium-dependent reactivity with phosphorylcholine residues. Phosphorylcholine 145-162 C-reactive protein Homo sapiens 20-23 6184312-2 1982 We had previously described a reaction of CRP with a monoclonal antiidiotype antibody to a murine phosphocholine (PCh) binding myeloma protein (5). Phosphorylcholine 98-112 C-reactive protein, pentraxin-related Mus musculus 42-45 7038026-0 1982 Mice with the xid defect have helper cells for T15 idiotype-dominant anti-phosphorylcholine primary and secondary plaque-forming cells responses. Phosphorylcholine 74-91 Bruton agammaglobulinemia tyrosine kinase Mus musculus 14-17 7041546-4 1982 Studies of its binding specificities have indicated that CRP has reactivity with (a) phosphocholine and phosphate esters, and hence with lipids widely distributed in mammalian and microbial cells; and (b) with multiple widely distributed polycations, including those derived from leukocyte granules. Phosphorylcholine 85-99 C-reactive protein Homo sapiens 57-60 6184312-2 1982 We had previously described a reaction of CRP with a monoclonal antiidiotype antibody to a murine phosphocholine (PCh) binding myeloma protein (5). Phosphorylcholine 114-117 C-reactive protein, pentraxin-related Mus musculus 42-45 7097779-3 1982 On enzymatic hydrolysis with phospholipase A2 and phospholipase C, lysophosphatidylcholine and phosphorylcholine were formed, respectively. Phosphorylcholine 95-112 phospholipase A2 group IB Homo sapiens 29-65 7046573-4 1982 Phosphorylcholine is bound by CRP with much higher affinity than other phosphate monoesters speaking for a second binding site with specificity for the positively charged trimethylammonium group. Phosphorylcholine 0-17 C-reactive protein Homo sapiens 30-33 7046573-6 1982 Protein that has been coupled with phosphorylcholine or phosphorylethanolamine is able to precipitate with CRP. Phosphorylcholine 35-52 C-reactive protein Homo sapiens 107-110 7046573-7 1982 Several natural substances including pneumococcal-C polysaccharide which react with CRP have been found to contain phosphorylcholine. Phosphorylcholine 115-132 C-reactive protein Homo sapiens 84-87 7276568-5 1981 However, in the presence of phosphocholine, CRP rapidly precipitated and formed stable complexes with the polycationic polymers in the otherwise inhibitory calcium concentrations. Phosphorylcholine 28-42 C-reactive protein Homo sapiens 44-47 7028874-9 1981 Reactivity of CRP with a multimeric form of phosphocholine (PC) (KLH-PC44) led to binding comparable to that observed with CPS, whereas monomeric PC inhibited the binding. Phosphorylcholine 44-58 C-reactive protein Homo sapiens 14-17 7028874-9 1981 Reactivity of CRP with a multimeric form of phosphocholine (PC) (KLH-PC44) led to binding comparable to that observed with CPS, whereas monomeric PC inhibited the binding. Phosphorylcholine 60-62 C-reactive protein Homo sapiens 14-17 7276568-7 1981 These results extend the characterization of the binding reactivity of CRP for polycations and suggest a relationship between this binding site and the sites for calcium and phosphocholine. Phosphorylcholine 174-188 C-reactive protein Homo sapiens 71-74 7276568-8 1981 We propose that CRP-polycation interactions in the presence of phosphocholine may have physiologic significance during the acute inflammatory process. Phosphorylcholine 63-77 C-reactive protein Homo sapiens 16-19 6274056-2 1981 EBV-infected cells were cultured in microtest plates for three weeks and specific antibody activities for sheep red blood cell (SRBC) were detected in the culture supernatants by hemolysis and those for phosphorylcholine (PC) and for hepatitis B surface antigen (HBsAg) by passive hemagglutination. Phosphorylcholine 203-220 CD2 molecule Homo sapiens 128-132 6166719-0 1981 Cross-reactivity between C-reactive protein and idiotypic determinants on A phosphocholine-binding murine myeloma protein. Phosphorylcholine 76-90 C-reactive protein, pentraxin-related Mus musculus 25-43 6166719-1 1981 Binding of human 125I-C-reactive protein (CRP) to sheep erythrocytes sensitized with pneumococcal C polysaccharide (E-PnC) was found to be Ca++ dependent and inhibitable by phosphocholine, CRP, and HOPC 8. Phosphorylcholine 173-187 C-reactive protein Homo sapiens 17-40 6166719-1 1981 Binding of human 125I-C-reactive protein (CRP) to sheep erythrocytes sensitized with pneumococcal C polysaccharide (E-PnC) was found to be Ca++ dependent and inhibitable by phosphocholine, CRP, and HOPC 8. Phosphorylcholine 173-187 C-reactive protein Homo sapiens 42-45 6166719-1 1981 Binding of human 125I-C-reactive protein (CRP) to sheep erythrocytes sensitized with pneumococcal C polysaccharide (E-PnC) was found to be Ca++ dependent and inhibitable by phosphocholine, CRP, and HOPC 8. Phosphorylcholine 173-187 C-reactive protein Ovis aries 189-192 6166719-3 1981 Thus, CRP and HOPC 8, despite a differential Ca++ requirement, share a common binding specificity for phosphocholine. Phosphorylcholine 102-116 C-reactive protein, pentraxin-related Mus musculus 6-9 6166719-10 1981 They also suggest that Ca++ acts as an allosteric effector, perhaps stabilizing the phosphocholine-binding site of CRP. Phosphorylcholine 84-98 C-reactive protein, pentraxin-related Mus musculus 115-118 6272753-11 1981 These results provide good evidence that the rate-limiting step for phosphatidylcholine biosynthesis in these cultured hepatocytes is the conversion of phosphocholine into CDP-choline. Phosphorylcholine 152-166 cut-like homeobox 1 Rattus norvegicus 172-175 7217669-4 1981 A weak interaction between CRP and agarose was observed, which was also CA++-dependent and could be inhibited by phosphocholine and galactose. Phosphorylcholine 113-127 C-reactive protein Homo sapiens 27-30 6253377-4 1980 During the biosynthesis of sphingomyelins, phosphocholine is being transferred from the donor CDP-choline to the primary alcohol group of ceramides. Phosphorylcholine 43-57 cut like homeobox 1 Homo sapiens 94-97 7462634-6 1981 We have found that this binding is more characteristic of CRP interactions with polycations than CRP interactions with phosphocholine- (PC) containing molecules. Phosphorylcholine 119-133 C-reactive protein Homo sapiens 97-100 7462634-6 1981 We have found that this binding is more characteristic of CRP interactions with polycations than CRP interactions with phosphocholine- (PC) containing molecules. Phosphorylcholine 136-138 C-reactive protein Homo sapiens 97-100 7329872-0 1981 A clinical assay for prostatic acid phosphatase using choline phosphate as a substrate: comparison with thymolphthalein phosphate. Phosphorylcholine 54-71 acid phosphatase 3 Homo sapiens 21-47 7329872-2 1981 Choline phosphate is hydrolyzed by homogeneous prostatic acid phosphatase, and it is also hydrolyzed by an acid phosphatase present in the serum of prostatic carcinoma patients. Phosphorylcholine 0-17 acid phosphatase 3 Homo sapiens 47-73 7329872-6 1981 Although not as sensitive as immunologically based methods, the present technique for measuring prostatic acid phosphatase activity using choline phosphate as a substrate is economical and relatively simple. Phosphorylcholine 138-155 acid phosphatase 3 Homo sapiens 96-122 688069-7 1978 The formation of CDP-choline was linear between 1 and 10 nmol of CTP or phosphocholine. Phosphorylcholine 72-86 cut-like homeobox 1 Rattus norvegicus 17-20 471064-3 1979 CRP has a Ca2+-dependent binding specificity for phosphorylcholine, the polar head group of two widely distributed lipids, lecithin (phosphatidylcholine, PC) and sphingomyelin (SM). Phosphorylcholine 49-66 C-reactive protein Homo sapiens 0-3 420816-4 1979 At sufficient immobilized phosphorylcholine concentration, the variation of elution volume of bivalent monomer with soluble ligand was found to deviate from that observed for the univalent binding of the corresponding Fab fragment. Phosphorylcholine 26-43 FA complementation group B Homo sapiens 218-221 7190145-2 1980 CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP. Phosphorylcholine 180-194 C-reactive protein Homo sapiens 0-3 7190145-4 1980 Although phosphatidylcholine is not an essential component for agglutination of suspensions, it may modify the mode of interaction of CRP with its binding site on lipid suspensions, since the sensitivity of the agglutination to phosphocholine and the Ca2+ requirement were influenced by the presence of phosphatidylcholine in the suspensions. Phosphorylcholine 228-242 C-reactive protein Homo sapiens 134-137 688069-5 1978 Similarly, the concentration of phosphocholine was estimated by the formation of 3H-labelled CDP-choline from 3H-labelled CTP. Phosphorylcholine 32-46 cut-like homeobox 1 Rattus norvegicus 93-96 688069-6 1978 The conversion of CTP and phosphocholine to CDP-choline was 90% when inorganic pyrophosphatase was added to the incubations. Phosphorylcholine 26-40 cut-like homeobox 1 Rattus norvegicus 44-47 199433-7 1977 Betaine and choline phosphate partially inhibited both kinases with a 93% inhibition of the ethanolamine kinase by 5 mM choline phosphate. Phosphorylcholine 12-29 choline kinase alpha Rattus norvegicus 92-111 209024-1 1978 The reaction catalyzed by CTP:phosphocholine cytidylyltransferase in the reverse direction, i.e. the formation of CTP and phosphocholine from CDP-choline and pyrophosphate, is slightly faster than the reaction in the forward direction. Phosphorylcholine 30-44 cut-like homeobox 1 Rattus norvegicus 142-145 199433-7 1977 Betaine and choline phosphate partially inhibited both kinases with a 93% inhibition of the ethanolamine kinase by 5 mM choline phosphate. Phosphorylcholine 120-137 choline kinase alpha Rattus norvegicus 92-111 71283-2 1977 The specificity of phosphorylcholine for PAP is attributable to the pentavalent nitrogen in phosphorylcholine, a feature that renders it resistant to hydrolysis by all other acid phosphatases. Phosphorylcholine 19-36 acid phosphatase 3 Homo sapiens 41-44 809531-8 1975 The relative inhibitory capacity of phosphorylcholine and polycations in CPS- and polycations-CRP systems was consistent with the concept that phosphate esters and polycations react at the same or an overlapping combining site. Phosphorylcholine 36-53 C-reactive protein Homo sapiens 94-97 71283-2 1977 The specificity of phosphorylcholine for PAP is attributable to the pentavalent nitrogen in phosphorylcholine, a feature that renders it resistant to hydrolysis by all other acid phosphatases. Phosphorylcholine 92-109 acid phosphatase 3 Homo sapiens 41-44 71283-6 1977 The specificity of PAP for phosphorylcholine, one of the natural substrates for this enzyme, validates the use of this method for the histochemical characterization of PAP and indicates the prostatic origin of cells showing PAP activity. Phosphorylcholine 27-44 acid phosphatase 3 Homo sapiens 19-22 71283-6 1977 The specificity of PAP for phosphorylcholine, one of the natural substrates for this enzyme, validates the use of this method for the histochemical characterization of PAP and indicates the prostatic origin of cells showing PAP activity. Phosphorylcholine 27-44 acid phosphatase 3 Homo sapiens 168-171 71283-6 1977 The specificity of PAP for phosphorylcholine, one of the natural substrates for this enzyme, validates the use of this method for the histochemical characterization of PAP and indicates the prostatic origin of cells showing PAP activity. Phosphorylcholine 27-44 acid phosphatase 3 Homo sapiens 168-171 977936-0 1976 The cytochemical demonstration of prostatic acid phosphatase using a new substrate, phosphorylcholine. Phosphorylcholine 84-101 acid phosphatase 3 Rattus norvegicus 34-60 977936-1 1976 Prostatic acid phosphatase (PAP), an acid phosphatase specific to the prostate gland, is demonstrated cytochemically for both light and electron microscopy with a new substrate phosphorylcholine. Phosphorylcholine 177-194 acid phosphatase 3 Rattus norvegicus 0-26 977936-1 1976 Prostatic acid phosphatase (PAP), an acid phosphatase specific to the prostate gland, is demonstrated cytochemically for both light and electron microscopy with a new substrate phosphorylcholine. Phosphorylcholine 177-194 acid phosphatase 3 Rattus norvegicus 28-31 977936-6 1976 Evidence is presented that PAP is not a lysosomal enzyme, as are other acid phosphatases, and that phosphorylcholine is a highly specific substrate for PAP. Phosphorylcholine 99-116 acid phosphatase 3 Rattus norvegicus 152-155 885587-7 1977 Inhibition studies demonstrated that PC is a potent inhibitor of the serum CRP-PPS and myeloma protein-PPS precipitation reactions. Phosphorylcholine 37-39 C-reactive protein Homo sapiens 75-78 14211-6 1977 Since C-reactive protein binds specifically to the phosphorylcholine residue of pneumococcal C-polysaccharide, it is unlikely that pneumococcal cell walls must combine with C-reactive protein in order to activate the alternative pathway. Phosphorylcholine 51-68 C-reactive protein Homo sapiens 6-24 5726197-3 1968 The results indicated that initial phosphorylation of the free choline followed by the formation of CDP-choline and the subsequent transfer of the phosphorylcholine to a diglyceride is one of the principal routes by which choline lipids in brain are formed. Phosphorylcholine 147-164 cut-like homeobox 1 Rattus norvegicus 100-103 238177-3 1975 Phosphorylcholine cytidyltransferase, the enzyme which catalyzes the transfer of phosphorylcholine to cytidine 5"-triphosphate to form CDP-choline, was studied for the first time in human neonatal lung. Phosphorylcholine 81-98 cut like homeobox 1 Homo sapiens 135-138 238177-6 1975 The Km of CTP was 2.0 times 10- minus 3 M, and the Km of phosphorylcholine was 0.25 times 10- minus 3 M. The true Vmax was 10 nmol CDP-choline/mg protein/10 min. Phosphorylcholine 57-74 cut like homeobox 1 Homo sapiens 131-134 805658-6 1975 The observation in biochemical experiments that phosphorylcholine is a very specific substrate for PAP has led us to develop specific cytochemical methods for PAP for both light and electron microscopy. Phosphorylcholine 48-65 acid phosphatase 3 Homo sapiens 99-102 805658-6 1975 The observation in biochemical experiments that phosphorylcholine is a very specific substrate for PAP has led us to develop specific cytochemical methods for PAP for both light and electron microscopy. Phosphorylcholine 48-65 acid phosphatase 3 Homo sapiens 159-162 805658-9 1975 Since the acid phosphatase that is able to hydrolyze phosphorylcholine is characteristic of prostatic epithelium, this is the acid phosphatase that is referred to be the designation of PAP. Phosphorylcholine 53-70 acid phosphatase 3 Homo sapiens 185-188 4395924-0 1971 Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Phosphorylcholine 38-55 C-reactive protein Homo sapiens 15-33 168873-5 1975 This indicated that CDP-choline was formed at a similar rate from phosphorylcholine and phosphatidylcholines, the latter probably through the reverse reaction of cholinephosphotransferase (EC 2.7.8.2.). Phosphorylcholine 66-83 cut-like homeobox 1 Rattus norvegicus 20-23 33898989-2 2021 We now investigated whether pharmacological targeting of the acid sphingomyelinase, which catalyzes the cleavage of sphingomyelin to ceramide and phosphorylcholine, also allows to manipulate relative CD4+ Foxp3+ regulatory T-cell frequencies in humans. Phosphorylcholine 146-163 sphingomyelin phosphodiesterase 1 Homo sapiens 61-82 13793779-0 1959 The effect of insulin on the formation of phosphorylcholine and phosphorylethanolamine in the brain. Phosphorylcholine 42-59 insulin Homo sapiens 14-21 33360080-10 2021 Additionally, fibrinogen adsorption and platelet adhesion were effectively suppressed based on the characteristics of the phosphorylcholine unit. Phosphorylcholine 122-139 fibrinogen beta chain Homo sapiens 14-24 33217383-3 2021 Visual rhodopsin was recombined with lipids varying in their degree of acyl chain unsaturation and polar headgroup size using 1-palmitoyl-2-oleoyl-sn-glycero- and 1,2-dioleoyl-sn-glycerophospholipids with phosphocholine (PC) or phosphoethanolamine (PE) headgroups. Phosphorylcholine 205-219 rhodopsin Homo sapiens 7-16 33217383-3 2021 Visual rhodopsin was recombined with lipids varying in their degree of acyl chain unsaturation and polar headgroup size using 1-palmitoyl-2-oleoyl-sn-glycero- and 1,2-dioleoyl-sn-glycerophospholipids with phosphocholine (PC) or phosphoethanolamine (PE) headgroups. Phosphorylcholine 221-223 rhodopsin Homo sapiens 7-16 33470509-1 2021 Self-assembled, lipid-based micelles, such as those formed by the short-chain phosphocholine, dihexanoylphosphatidylcholine (2C6PC), are degraded by the pancreatic enzyme, phospholipase A2 (PLA2). Phosphorylcholine 78-92 phospholipase A2 group IB Homo sapiens 172-188 32684402-2 2021 Phosphorylcholine (ChoP) is expressed on lipooligosaccharides, and ChoP has phase variation, which is related to its adhesion to and invasion of epithelial cells in the upper airway. Phosphorylcholine 0-17 DNA-damage inducible transcript 3 Mus musculus 19-23 33470509-1 2021 Self-assembled, lipid-based micelles, such as those formed by the short-chain phosphocholine, dihexanoylphosphatidylcholine (2C6PC), are degraded by the pancreatic enzyme, phospholipase A2 (PLA2). Phosphorylcholine 78-92 phospholipase A2 group IB Homo sapiens 190-194 33440601-9 2021 AnxA1 peptidomimetic treatment also increased the concentration of phosphatidylserines and oxidized phosphocholines, which are lipid biomarkers related to the inflammatory resolution pathway. Phosphorylcholine 100-115 annexin A1 Mus musculus 0-5 33693294-0 2021 Phosphorylcholine-Primed Dendritic Cells Aggravate the Development of Atherosclerosis in ApoE-/- Mice. Phosphorylcholine 0-17 apolipoprotein E Mus musculus 89-93 32723380-13 2020 Gene-set-enrichment-analyses identified 2-upregulated pathways (MAPK signaling and phosphocholine biosynthesis) enriched at FDR < 25% in ER-negative tumors and normal-adjacent tissues, and both pathways have been previously reported to play key roles in ionizing radiation induced tumorigenesis in experimental settings. Phosphorylcholine 83-97 estrogen receptor 1 Homo sapiens 137-139 32864834-2 2020 CP-beta-CD has excellent cell-membrane-targeted ability because of the CP group can bind to phosphate choline (PC) in the cell membrane and promote the cellular uptake. Phosphorylcholine 92-109 carboxypeptidase A1 Homo sapiens 0-7 32864834-2 2020 CP-beta-CD has excellent cell-membrane-targeted ability because of the CP group can bind to phosphate choline (PC) in the cell membrane and promote the cellular uptake. Phosphorylcholine 111-113 carboxypeptidase A1 Homo sapiens 0-7 33224343-3 2020 Methods: In order to test the possibility of direct interaction, we performed an in silico study by testing the orientation of the respective ligands (statins) and phosphorylcholine (the standard ligand of CRP) in the CRP active site using Molecular Operating Environment (MOE) software. Phosphorylcholine 164-181 C-reactive protein Homo sapiens 206-209 33224343-3 2020 Methods: In order to test the possibility of direct interaction, we performed an in silico study by testing the orientation of the respective ligands (statins) and phosphorylcholine (the standard ligand of CRP) in the CRP active site using Molecular Operating Environment (MOE) software. Phosphorylcholine 164-181 C-reactive protein Homo sapiens 218-221 33224343-6 2020 According to the above-mentioned results, rosuvastatin, fluvastatin, pitavastatin and atorvastatin were found to have stronger binding to CRP compared with the standard ligand phosphocholine (pKi = 14.55). Phosphorylcholine 176-190 C-reactive protein Homo sapiens 138-141 33088808-1 2020 Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane. Phosphorylcholine 123-137 sphingomyelin phosphodiesterase 3 Homo sapiens 0-26 33088808-1 2020 Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane. Phosphorylcholine 123-137 sphingomyelin phosphodiesterase 3 Homo sapiens 28-32 32903624-3 2020 in vitro, CRP binds to phosphocholine-containing substances, such as pneumococcal C-polysaccharide, in a Ca2+-dependent manner. Phosphorylcholine 23-37 C-reactive protein, pentraxin-related Mus musculus 10-13 32903624-4 2020 Phosphocholine-complexed human CRP activates the complement system in both human and murine sera. Phosphorylcholine 0-14 C-reactive protein Homo sapiens 31-34 32903624-6 2020 In this study, we tested a decades-old hypothesis that the complement-activating property of phosphocholine-complexed CRP contributes to protection of mice against pneumococcal infection. Phosphorylcholine 93-107 C-reactive protein, pentraxin-related Mus musculus 118-121 32903624-12 2020 Thus, the hypothesis that complement activation by phosphocholine-complexed CRP is an antipneumococcal effector function was supported. Phosphorylcholine 51-65 C-reactive protein, pentraxin-related Mus musculus 76-79 32903624-13 2020 We can conclude now that complement activation by phosphocholine-complexed CRP is indeed essential for CRP-mediated protection of mice against pneumococcal infection. Phosphorylcholine 50-64 C-reactive protein, pentraxin-related Mus musculus 75-78 32903624-13 2020 We can conclude now that complement activation by phosphocholine-complexed CRP is indeed essential for CRP-mediated protection of mice against pneumococcal infection. Phosphorylcholine 50-64 C-reactive protein, pentraxin-related Mus musculus 103-106 32849641-4 2020 CRP binds to phosphocholine-containing molecules but does not interact with LDL unless the phosphocholine groups in LDL are exposed. Phosphorylcholine 13-27 C-reactive protein, pentraxin-related Mus musculus 0-3 32849641-4 2020 CRP binds to phosphocholine-containing molecules but does not interact with LDL unless the phosphocholine groups in LDL are exposed. Phosphorylcholine 91-105 C-reactive protein, pentraxin-related Mus musculus 0-3 32990984-1 2021 Oxidized phospholipids containing phosphocholine (OxPL) are pro-inflammatory lipid peroxidation products that bind to scavenger receptors (SRs), such as Scarb1, and toll-like receptors (TLRs). Phosphorylcholine 34-48 scavenger receptor class B, member 1 Mus musculus 153-159 32665303-6 2020 These assays used antibodies raised against antigens that enabled us to measure the absorbance of oxidised phosphocholines per apolipoprotein B-100 (ox-PC/apoB) and the concentration of lipoprotein(a) (Lp(a)) and beta-1,4 GalT-V. Phosphorylcholine 107-122 apolipoprotein B Homo sapiens 127-147 32298582-1 2020 Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Phosphorylcholine 80-97 sphingomyelin phosphodiesterase 3 Homo sapiens 0-26 32554489-1 2020 Phosphocholine phosphatase-1 (PHOSPHO1) is a phosphocholine phosphatase that catalyzes the hydrolysis of phosphocholine (PC) to choline. Phosphorylcholine 45-59 phosphatase, orphan 1 Mus musculus 0-28 32554489-1 2020 Phosphocholine phosphatase-1 (PHOSPHO1) is a phosphocholine phosphatase that catalyzes the hydrolysis of phosphocholine (PC) to choline. Phosphorylcholine 45-59 phosphatase, orphan 1 Mus musculus 30-38 32554489-1 2020 Phosphocholine phosphatase-1 (PHOSPHO1) is a phosphocholine phosphatase that catalyzes the hydrolysis of phosphocholine (PC) to choline. Phosphorylcholine 121-123 phosphatase, orphan 1 Mus musculus 0-28 32554489-1 2020 Phosphocholine phosphatase-1 (PHOSPHO1) is a phosphocholine phosphatase that catalyzes the hydrolysis of phosphocholine (PC) to choline. Phosphorylcholine 121-123 phosphatase, orphan 1 Mus musculus 30-38 32554489-4 2020 Treatment of mice with the PHOSPHO1 substrate phosphocholine is sufficient to induce cold tolerance, thermogenic gene expression, and allied metabolic benefits. Phosphorylcholine 46-60 phosphatase, orphan 1 Mus musculus 27-35 32298582-1 2020 Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Phosphorylcholine 80-97 sphingomyelin phosphodiesterase 3 Homo sapiens 28-35 32374279-5 2021 CRP was assayed using a functional turbidimetric assay based on the interaction of CRP with phosphocholine containing particles (Intralipid ). Phosphorylcholine 92-106 C-reactive protein Homo sapiens 0-3 32156719-1 2020 Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Phosphorylcholine 127-144 sphingomyelin phosphodiesterase 1 Homo sapiens 14-35 32156719-1 2020 Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Phosphorylcholine 127-144 sphingomyelin phosphodiesterase 1 Homo sapiens 37-40 32269097-9 2020 Interaction of phosphocholine groups on VLDL with CRP is the major driver for complex formation and phosphocholine can disrupt the complexes to reverse their inhibitory effects on phagocytosis and bacterial clearance. Phosphorylcholine 15-29 C-reactive protein Homo sapiens 50-53 32269097-9 2020 Interaction of phosphocholine groups on VLDL with CRP is the major driver for complex formation and phosphocholine can disrupt the complexes to reverse their inhibitory effects on phagocytosis and bacterial clearance. Phosphorylcholine 100-114 C-reactive protein Homo sapiens 50-53 32374279-5 2021 CRP was assayed using a functional turbidimetric assay based on the interaction of CRP with phosphocholine containing particles (Intralipid ). Phosphorylcholine 92-106 C-reactive protein Homo sapiens 83-86 31935056-2 2020 In this study, we prepared and tested example mono- and disaccharides 6-substituted with either phosphorylcholine or phosphoethanolamine as bovine serum albumin neoglycoconjugates or printed in a microarray format for subsequent assessment of their binding to lectins, pentraxins, and antibodies. Phosphorylcholine 96-113 albumin Canis lupus familiaris 147-160 32228944-2 2020 The 2-methacryloyloxyethyl phosphorylcholine (MPC) was first reacted with alpha-thioglycerol by Michael addition to give a diol compound (MPC-diol), then the SPU-PCs with various PC content were prepared by a one-step chain extension of the mixture of MPC-diol and poly(epsilon-caprolactone) diol (PCL-diol) with aliphatic diurethane diisocyanates (HBH). Phosphorylcholine 47-49 hemoglobin subunit alpha 1 Homo sapiens 349-352 31935056-3 2020 C-Reactive protein and anti-phosphorylcholine antibodies bound specifically to ligands with phosphorylcholine, but recognition by concanavalin A was abolished or decreased as compared with that to the corresponding nonzwitterionic compounds. Phosphorylcholine 92-109 C-reactive protein Canis lupus familiaris 0-18 31302689-0 2020 IgM anti-phosphorylcholine antibodies associate with senescent and IL-17+ T cells in SLE patients with a pro-inflammatory lipid profile. Phosphorylcholine 9-26 interleukin 17A Homo sapiens 67-72 32117266-1 2020 A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an optimized concentration of 3 M urea over a 10 weeks period. Phosphorylcholine 173-187 C-reactive protein Homo sapiens 20-38 32117266-1 2020 A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an optimized concentration of 3 M urea over a 10 weeks period. Phosphorylcholine 173-187 C-reactive protein Homo sapiens 40-43 32117266-6 2020 Both the in vitro monomeric C-reactive protein and the human serum monomeric protein displayed a molecular weight of approximately 23 kDa, both were recognized by the same anti-CRP monoclonal antibody and both reversibly bound to phosphocholine in a calcium-dependent manner. Phosphorylcholine 230-244 C-reactive protein Homo sapiens 28-46 32117266-6 2020 Both the in vitro monomeric C-reactive protein and the human serum monomeric protein displayed a molecular weight of approximately 23 kDa, both were recognized by the same anti-CRP monoclonal antibody and both reversibly bound to phosphocholine in a calcium-dependent manner. Phosphorylcholine 230-244 C-reactive protein Homo sapiens 177-180 31841776-6 2020 NMR metabolomics revealed that macrophages incubated with smaller PG-FMN displayed increased levels of succinate, itaconate, phosphocholine and phosphocreatine, together with decreased creatine content. Phosphorylcholine 125-139 formin 1 Homo sapiens 69-72 31826940-5 2020 Using stable isotope labeling, we demonstrated that phosphocholine and phosphatidylcholine biosynthesis was markedly elevated in Traf3 -/- mouse B cells and decreased in TRAF3-reconstituted human multiple myeloma cells. Phosphorylcholine 52-66 TNF receptor-associated factor 3 Mus musculus 129-134 31826940-5 2020 Using stable isotope labeling, we demonstrated that phosphocholine and phosphatidylcholine biosynthesis was markedly elevated in Traf3 -/- mouse B cells and decreased in TRAF3-reconstituted human multiple myeloma cells. Phosphorylcholine 52-66 TNF receptor-associated factor 3 Mus musculus 170-175 31826940-6 2020 Furthermore, pharmacological inhibition of choline kinase alpha, an enzyme that catalyzes phosphocholine synthesis and was strikingly increased in Traf3 -/- B cells, substantially reversed the survival phenotype of Traf3 -/- B cells both in vitro and in vivo. Phosphorylcholine 90-104 choline kinase alpha Mus musculus 43-63 31826940-6 2020 Furthermore, pharmacological inhibition of choline kinase alpha, an enzyme that catalyzes phosphocholine synthesis and was strikingly increased in Traf3 -/- B cells, substantially reversed the survival phenotype of Traf3 -/- B cells both in vitro and in vivo. Phosphorylcholine 90-104 TNF receptor associated factor 3 Homo sapiens 215-220 31826940-7 2020 Taken together, our results indicate that enhanced phosphocholine and phosphatidylcholine synthesis supports the prolonged survival of Traf3 -/- B lymphocytes. Phosphorylcholine 51-65 TNF receptor associated factor 3 Homo sapiens 135-140 31941852-1 2020 Acid sphingomyelinase (ASM) is a lysosomal hydrolase that degrades sphingomyelin into ceramide and phosphocholine. Phosphorylcholine 99-113 sphingomyelin phosphodiesterase 1 Homo sapiens 0-21 31840602-6 2020 At sites of local inflammation and tissue injury it may bind to phosphocholine-rich membranes of activated and apoptotic cells and their microparticles, undergoing irreversible dissociation to five monomeric subunits, termed monomeric CRP (mCRP). Phosphorylcholine 64-78 C-reactive protein Homo sapiens 235-238 32526213-2 2020 Lipoprotein(a) [Lp (a)] is a cholesterol rich particle secreted by the liver which functions as the major lipoprotein carrier of phosphocholine-containing oxidized phospholipids. Phosphorylcholine 129-143 lipoprotein(a) Homo sapiens 0-14 32526213-2 2020 Lipoprotein(a) [Lp (a)] is a cholesterol rich particle secreted by the liver which functions as the major lipoprotein carrier of phosphocholine-containing oxidized phospholipids. Phosphorylcholine 129-143 lipoprotein(a) Homo sapiens 16-22 31941852-1 2020 Acid sphingomyelinase (ASM) is a lysosomal hydrolase that degrades sphingomyelin into ceramide and phosphocholine. Phosphorylcholine 99-113 sphingomyelin phosphodiesterase 1 Homo sapiens 23-26 31681760-1 2019 The activity of neutral sphingomyelinase-2 (NSM2) to catalyze the conversion of sphingomyelin (SM) to ceramide and phosphocholine at the cytosolic leaflet of plasma membrane (PM) is important in T cell receptor (TCR) signaling. Phosphorylcholine 115-129 sphingomyelin phosphodiesterase 3 Homo sapiens 16-42 31745227-1 2019 Choline kinase alpha is a 457-residue protein that catalyzes the reaction between ATP and choline to yield ADP and phosphocholine. Phosphorylcholine 115-129 choline kinase alpha Homo sapiens 0-20 31823769-7 2019 ApoE-/- mice that received in vitro expanded splenic ILC2s had decreased lipid content in subvalvular heart and brachiocephalic artery (BCA) plaques accompanied by increased peritoneal B1 cells, activated eosinophils and alternatively activated macrophages (AAMs) as well as anti-phosphorylcholine (PC) immunoglobulin (Ig) M in plasma. Phosphorylcholine 280-297 apolipoprotein E Mus musculus 0-4 31400172-7 2019 These results suggest that NPC2 and NPC6 may be involved in root growth by producing phosphocholine via metabolic interaction with a PMT-catalyzed pathway, which highlights a tissue-specific role of NPC enzymes in vegetative growth beyond the gametophyte-lethal phenotype. Phosphorylcholine 85-99 non-specific phospholipase C2 Arabidopsis thaliana 27-31 31400172-7 2019 These results suggest that NPC2 and NPC6 may be involved in root growth by producing phosphocholine via metabolic interaction with a PMT-catalyzed pathway, which highlights a tissue-specific role of NPC enzymes in vegetative growth beyond the gametophyte-lethal phenotype. Phosphorylcholine 85-99 non-specific phospholipase C6 Arabidopsis thaliana 36-40 31681760-1 2019 The activity of neutral sphingomyelinase-2 (NSM2) to catalyze the conversion of sphingomyelin (SM) to ceramide and phosphocholine at the cytosolic leaflet of plasma membrane (PM) is important in T cell receptor (TCR) signaling. Phosphorylcholine 115-129 sphingomyelin phosphodiesterase 3 Homo sapiens 44-48 31681760-1 2019 The activity of neutral sphingomyelinase-2 (NSM2) to catalyze the conversion of sphingomyelin (SM) to ceramide and phosphocholine at the cytosolic leaflet of plasma membrane (PM) is important in T cell receptor (TCR) signaling. Phosphorylcholine 115-129 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 195-210 31681760-1 2019 The activity of neutral sphingomyelinase-2 (NSM2) to catalyze the conversion of sphingomyelin (SM) to ceramide and phosphocholine at the cytosolic leaflet of plasma membrane (PM) is important in T cell receptor (TCR) signaling. Phosphorylcholine 115-129 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 212-215 31418690-4 2019 Macrophage-specific knockout of phosphocholine cytidylyltransferase A (CCTalpha), the rate-limiting enzyme of de novo PC biosynthesis pathway, alleviated obesity-induced WAT inflammation and insulin resistance. Phosphorylcholine 32-46 phosphate cytidylyltransferase 1A, choline Homo sapiens 71-79 31379173-4 2019 Herein, a gadolinium/adenosine monophosphate (Gd3+/AMP) shell was formed on liposomes (liposome@Gd3+/AMP) using lipids containing phosphoserine (PS) or cholinephosphate (CP) headgroups, while phosphocholine liposomes did not support the shell. Phosphorylcholine 152-168 GRDX Homo sapiens 46-49 31379173-4 2019 Herein, a gadolinium/adenosine monophosphate (Gd3+/AMP) shell was formed on liposomes (liposome@Gd3+/AMP) using lipids containing phosphoserine (PS) or cholinephosphate (CP) headgroups, while phosphocholine liposomes did not support the shell. Phosphorylcholine 192-206 GRDX Homo sapiens 46-49 31418690-4 2019 Macrophage-specific knockout of phosphocholine cytidylyltransferase A (CCTalpha), the rate-limiting enzyme of de novo PC biosynthesis pathway, alleviated obesity-induced WAT inflammation and insulin resistance. Phosphorylcholine 32-46 insulin Homo sapiens 191-198