PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7891027-5	1995	Inclusion of a low dose (80 units/l) of porcine plasmin led to a small increase in incorporation of [methyl-3H]thymidine, while higher doses of plasmin (1250-5000 units/l) or plasminogen (100 mg/l) significantly reduced [methyl-3H]thymidine incorporation.	methyl-3h	101-110	plasminogen	Homo sapiens	48-55
8119691-3	1994	Macrophage colony-stimulating factor and recombinant murine granulocyte-macrophage colony-stimulating factor stimulated [methyl-3H]thymidine incorporation in a concentration-dependent manner.	methyl-3h	121-130	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	60-108
8106747-4	1994	[Methyl-3H] thymidine autoradiography was carried out to investigate the patterns of DNA synthesis and showed that epidermal growth factor inhibited DNA synthesis in the hair follicle matrix cells but dramatically stimulated DNA synthesis in the outer root sheath.	methyl-3h	1-10	epidermal growth factor	Homo sapiens	115-138
7968218-9	1994	The activating effect on incorporation of 3H-thymidine (methyl-3H) was suppressed by anti-human MGF antibody in a dose-dependent manner.	methyl-3h	56-65	insulin like growth factor 1	Homo sapiens	96-99
3545450-4	1987	Incubation of tumor plasma membranes with methyl-3H-labeled collagen resulted in extensive degradation of the gamma, beta, alpha 1, and alpha 2 chains, suggesting the combined action of metalloproteinases.	methyl-3h	42-51	adrenoceptor alpha 1D	Homo sapiens	110-143
1476919-6	1992	On maintenance, fetal calf serum (FCS), epidermal growth factor (EGF) and 12-o-tetradecanoyl phorbol 13-acetate (TPA) all significantly stimulated [methyl-3H] thymidine and [U-14C] leucine uptake, but inhibited hair follicle elongation.	methyl-3h	148-157	epidermal growth factor like 1	Rattus norvegicus	40-63
1476919-6	1992	On maintenance, fetal calf serum (FCS), epidermal growth factor (EGF) and 12-o-tetradecanoyl phorbol 13-acetate (TPA) all significantly stimulated [methyl-3H] thymidine and [U-14C] leucine uptake, but inhibited hair follicle elongation.	methyl-3h	148-157	epidermal growth factor like 1	Rattus norvegicus	65-68
1476606-4	1992	The TGF-beta 1 peptide content of TFC-conditioned media (TFC-CM) was assessed using the fetal mink lung cell line Mv1Lu, in which activated TGF-beta 1 specifically suppresses trichloroacetic acid-precipitable [methyl-3H]thymidine incorporation.	methyl-3h	210-219	transforming growth factor beta 1	Homo sapiens	140-150
1476606-5	1992	Newly conditioned TFC-CM stimulated [methyl-3H]thymidine incorporation into Mv1Lu cells, but after heat treatment to inactivate growth stimulators and activate the latent TGF-beta 1 component this medium inhibited [methyl-3H]thymidine incorporation.	methyl-3h	37-46	transforming growth factor beta 1	Homo sapiens	171-181
1476606-5	1992	Newly conditioned TFC-CM stimulated [methyl-3H]thymidine incorporation into Mv1Lu cells, but after heat treatment to inactivate growth stimulators and activate the latent TGF-beta 1 component this medium inhibited [methyl-3H]thymidine incorporation.	methyl-3h	215-224	transforming growth factor beta 1	Homo sapiens	171-181
1567883-2	1992	The incorporation of radioactivity shows no lag and is linear with respect to time up to 1 h. The photolabeling is saturable with [methyl-3H]AdoMet, and the binding constant of the enzyme for AdoMet determined in this experiment is similar to that obtained by equilibrium dialysis.	methyl-3h	131-140	methionine adenosyltransferase 1A	Rattus norvegicus	141-147
1567883-2	1992	The incorporation of radioactivity shows no lag and is linear with respect to time up to 1 h. The photolabeling is saturable with [methyl-3H]AdoMet, and the binding constant of the enzyme for AdoMet determined in this experiment is similar to that obtained by equilibrium dialysis.	methyl-3h	131-140	methionine adenosyltransferase 1A	Rattus norvegicus	192-198
1567883-6	1992	Following proteolysis of the [methyl-3H]-AdoMet-labeled enzyme with chymotrypsin, a radioactive peptide is isolated having a sequence Asp-Thr-X-Pro-Leu-Ser-Glu-Glu-Thr-Trp.	methyl-3h	30-39	methionine adenosyltransferase 1A	Rattus norvegicus	41-47
2070498-4	1991	The MGMT activity was assayed by measuring the 3H radioactivity transferred from the substrate DNA containing [methyl-3H]-labeled O6-methylguanine to an acid-insoluble protein fraction.	methyl-3h	111-120	O-6-methylguanine-DNA methyltransferase	Homo sapiens	4-8
2160828-6	1990	However, blockade of transmembrane Na+/H+ exchange with amiloride inhibited both the individual actions of IGF-I and PMA on [methyl-3H]thymidine incorporation, and the synergistic interaction between TSH and IGF-I.	methyl-3h	125-134	insulin-like growth factor 1	Rattus norvegicus	107-112
2473136-5	1989	Maximal stimulation of quiescent BALB/MK cells with epidermal growth factor (EGF) caused a 70- to 100-fold increase of [methyl-3H]-thymidine incorporation into DNA.	methyl-3h	120-129	epidermal growth factor	Mus musculus	52-75
2473136-5	1989	Maximal stimulation of quiescent BALB/MK cells with epidermal growth factor (EGF) caused a 70- to 100-fold increase of [methyl-3H]-thymidine incorporation into DNA.	methyl-3h	120-129	epidermal growth factor	Mus musculus	77-80
6333210-4	1984	In unstimulated cells, incorporation of methyl-3H into phospholipid was 0.60 +/- 0.06 pmol min-1 mg protein in neutrophil membrane, 0.84 +/- 0.075 in unseparated lymphocytes, 1.23 +/- 0.17 in T lymphocytes, and 0.71 +/- 0.085 in non-T lymphocytes (mean +/- SE).	methyl-3h	40-49	CD59 molecule (CD59 blood group)	Homo sapiens	91-96
3700427-8	1986	Purified calmodulin N-methyltransferase was incubated with extracts of rat tissues, and [methyl-3H]AdoMet and methylated proteins were resolved by electrophoresis in an attempt to discover substances other than calmodulin, but this enzyme only catalyzed the methylation of calmodulin, indicating a high degree of substrate specificity.	methyl-3h	89-98	calmodulin 1	Rattus norvegicus	9-19
17301166-8	2007	The gliotrophic effect of PrP 82-146 was determined by [methyl-3H]-thymidine incorporation in cultured astrocytes.	methyl-3h	56-65	prion protein	Mus musculus	26-29
468844-2	1979	Isolation of microsomal and lamellar body fractions from adenomas after a 20-min pulse with [methyl-3H]choline demonstrates that Sat2PC first appears in the microsomal fraction, and after a short lag subsequently appears in the lamellar body fraction.	methyl-3h	93-102	spermidine/spermine N1-acetyl transferase 2	Mus musculus	129-133
17465218-0	2007	[Methyl-3H]-choline incorporation into MCF-7 cells: correlation with proliferation, choline kinase and phospholipase D assay.	methyl-3h	1-10	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	103-118
17465218-2	2007	In this study, whether [methyl-3H]-choline determined by measuring the activity of choline kinase (ChoK) and phospholipase D (PLD) in rapidly proliferating and confluent breast cancer MCF-7 cells is related to cell proliferation or not was investigated.	methyl-3h	24-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-124
17465218-2	2007	In this study, whether [methyl-3H]-choline determined by measuring the activity of choline kinase (ChoK) and phospholipase D (PLD) in rapidly proliferating and confluent breast cancer MCF-7 cells is related to cell proliferation or not was investigated.	methyl-3h	24-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
15569411-3	2004	RESULTS: (1) VIP (10(-10)-10(-7) mol/L) for 16 h promoted [methyl-3H]choline incorporation in dose dependence and VIP (10(-8) mol/L) for 2 h-16 h promoted [methyl-3H]choline incorporation in time dependence.	methyl-3h	156-165	vasoactive intestinal peptide	Homo sapiens	13-16
16445569-9	2005	Inhibition of MEK/ERK with the pharmacological inhibitors U0126 (10 micromol/L) or PD98059 (20 micromol/L) together with As2O3 (2 and 5 micromol/L) resulted in a significant enhancement of growth inhibition in breast cancer MCF-7 cells as determined by the 3-(4,5-dimethyl-2 thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide assay and [Methyl-3H]-thymidine incorporation.	methyl-3h	332-341	mitogen-activated protein kinase kinase 7	Homo sapiens	14-17
16445569-9	2005	Inhibition of MEK/ERK with the pharmacological inhibitors U0126 (10 micromol/L) or PD98059 (20 micromol/L) together with As2O3 (2 and 5 micromol/L) resulted in a significant enhancement of growth inhibition in breast cancer MCF-7 cells as determined by the 3-(4,5-dimethyl-2 thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide assay and [Methyl-3H]-thymidine incorporation.	methyl-3h	332-341	mitogen-activated protein kinase 1	Homo sapiens	18-21
15569411-3	2004	RESULTS: (1) VIP (10(-10)-10(-7) mol/L) for 16 h promoted [methyl-3H]choline incorporation in dose dependence and VIP (10(-8) mol/L) for 2 h-16 h promoted [methyl-3H]choline incorporation in time dependence.	methyl-3h	59-68	vasoactive intestinal peptide	Homo sapiens	13-16
8568475-2	1996	Primary monolayer TFC cultures exposed to EGF over the range 0-0.4 nmol/l showed a dose-dependent increase in [methyl-3H]thymidine incorporation, whereas higher EGF doses were associated with a reduction in the level of [methyl-3H]thymidine incorporation.	methyl-3h	111-120	epidermal growth factor	Homo sapiens	42-45
10580548-5	1999	Inhibition of [methyl-3H]thymidine incorporation by IL-1beta was lower than that observed with HUVEC, while TNF-alpha reduced the proliferation of IVEC and HUVEC to similar extents.	methyl-3h	15-24	interleukin 1 beta	Homo sapiens	52-60
9832394-7	1998	On the other hand, the time-course of translocation/down-regulation of protein kinase C alpha and protein kinase C epsilon induced by PMA was in good correlation with the time-course of PMA-induced [methyl-3H]thymidine incorporation.	methyl-3h	199-208	protein kinase C alpha	Homo sapiens	71-93
8568475-2	1996	Primary monolayer TFC cultures exposed to EGF over the range 0-0.4 nmol/l showed a dose-dependent increase in [methyl-3H]thymidine incorporation, whereas higher EGF doses were associated with a reduction in the level of [methyl-3H]thymidine incorporation.	methyl-3h	221-230	epidermal growth factor	Homo sapiens	42-45
8568475-3	1996	TGF-beta immunoneutralisation had little effect on the stimulatory action of low EGF doses, but led to an increase in [methyl-3H]thymidine incorporation at higher EGF levels.	methyl-3h	119-128	transforming growth factor beta 1	Homo sapiens	0-8
8745146-3	1995	Confirmation of a mediating role of IGF-I in TFC proliferation was obtained by exposing TFCs to an immunoadsorbing IGF-I antiserum, which led to a significant (P < 0.05) decline in [methyl-3H]thymidine incorporation, relative to TFCs exposed to preimmune serum.	methyl-3h	185-194	insulin like growth factor 1	Homo sapiens	36-41
8745146-3	1995	Confirmation of a mediating role of IGF-I in TFC proliferation was obtained by exposing TFCs to an immunoadsorbing IGF-I antiserum, which led to a significant (P < 0.05) decline in [methyl-3H]thymidine incorporation, relative to TFCs exposed to preimmune serum.	methyl-3h	185-194	insulin like growth factor 1	Homo sapiens	115-120