PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11041857-3	2000	CD39L4 is a soluble E-nucleoside triphosphate dephosphohydrolase (E-NTPDase) with specificity for nucleotide diphosphates (NDPs).	nucleotide diphosphates	98-121	ectonucleoside triphosphate diphosphohydrolase 5 (inactive)	Homo sapiens	0-6
27387229-4	2016	Here, we found that, unlike conventional hydrolytic exoribonucleases, SAMHD1 requires inorganic phosphate to degrade RNA substrates and produces nucleotide diphosphates rather than nucleoside monophosphates, which indicated that SAMHD1 is a phosphorolytic but not hydrolytic 3"-5" exoribonuclease.	nucleotide diphosphates	145-168	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	70-76
27387229-4	2016	Here, we found that, unlike conventional hydrolytic exoribonucleases, SAMHD1 requires inorganic phosphate to degrade RNA substrates and produces nucleotide diphosphates rather than nucleoside monophosphates, which indicated that SAMHD1 is a phosphorolytic but not hydrolytic 3"-5" exoribonuclease.	nucleotide diphosphates	145-168	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	229-235
12637029-2	2003	At pH 7.5, NTPDase1 hydrolyzed nucleotide triphosphates at rates 2.4-fold higher than those of nucleotide diphosphates, while the hydrolysis of nucleotide monophosphates and non-nucleotide phosphates was negligible.	nucleotide diphosphates	95-118	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	11-19
22351996-0	2011	[Mechanistic insight into hydrolysis of oxidized nucleotide diphosphates by human NUDT5].	nucleotide diphosphates	49-72	nudix hydrolase 5	Homo sapiens	82-87
15145932-6	2004	In addition, DNA and RNA polymer-related compounds, such as nucleotide diphosphates and triphosphates, also inhibit the carbohydrate binding ability of SP-D, or approximately 60 kDa trimeric recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).	nucleotide diphosphates	60-83	surfactant associated protein D	Mus musculus	152-156
15145932-6	2004	In addition, DNA and RNA polymer-related compounds, such as nucleotide diphosphates and triphosphates, also inhibit the carbohydrate binding ability of SP-D, or approximately 60 kDa trimeric recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).	nucleotide diphosphates	60-83	surfactant associated protein D	Mus musculus	216-220
15145932-6	2004	In addition, DNA and RNA polymer-related compounds, such as nucleotide diphosphates and triphosphates, also inhibit the carbohydrate binding ability of SP-D, or approximately 60 kDa trimeric recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).	nucleotide diphosphates	60-83	surfactant associated protein D	Mus musculus	216-220
15145932-6	2004	In addition, DNA and RNA polymer-related compounds, such as nucleotide diphosphates and triphosphates, also inhibit the carbohydrate binding ability of SP-D, or approximately 60 kDa trimeric recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).	nucleotide diphosphates	60-83	surfactant associated protein D	Mus musculus	216-220
11041857-3	2000	CD39L4 is a soluble E-nucleoside triphosphate dephosphohydrolase (E-NTPDase) with specificity for nucleotide diphosphates (NDPs).	nucleotide diphosphates	98-121	ectonucleoside triphosphate diphosphohydrolase 8	Homo sapiens	20-64
11041857-3	2000	CD39L4 is a soluble E-nucleoside triphosphate dephosphohydrolase (E-NTPDase) with specificity for nucleotide diphosphates (NDPs).	nucleotide diphosphates	98-121	ectonucleoside triphosphate diphosphohydrolase 8	Homo sapiens	66-75
9651346-3	1998	More significantly, this RNA-binding protein is able to degrade RNAs with the resultant production of nucleotide diphosphates, and it can add extended polyadenylate tracts to RNAs using ADP as a donor for adenylate moieties.	nucleotide diphosphates	102-125	RNA binding motif single stranded interacting protein 3	Homo sapiens	25-44
9877232-1	1998	Nucleoside diphosphate kinase (NDP kinase) catalyzes the transfer of terminal phosphate from nucleotide triphosphates (e.g. ATP) to nucleotide diphosphates (e.g. GDP) to yield nucleotide triphosphates (e.g. GTP).	nucleotide diphosphates	132-155	cytidine/uridine monophosphate kinase 1	Rattus norvegicus	31-41
31177779-2	2019	Recently, another hypothesis for the Ga3+ curative effect has been put forward: the metal cation can deactivate the enzyme by entrapping its substrates (nucleotide diphosphates; NDPs) into Ga3+-NDP complexes, lowering the free substrate levels in the cell.	nucleotide diphosphates	153-176	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	37-40
8700127-12	1996	The data indicate that the P2Y2 receptor is activated with similar potencies by ATP and UTP but not by ADP or UDP; the P2Y6 receptor is activated most potently by UDP but weakly by UTP, ATP, and ADP; and the P2Y4 receptor is activated most potently by UTP, less potently by ATP, and not at all by nucleotide diphosphates.	nucleotide diphosphates	297-320	pyrimidinergic receptor P2Y6	Homo sapiens	119-123
8700127-12	1996	The data indicate that the P2Y2 receptor is activated with similar potencies by ATP and UTP but not by ADP or UDP; the P2Y6 receptor is activated most potently by UDP but weakly by UTP, ATP, and ADP; and the P2Y4 receptor is activated most potently by UTP, less potently by ATP, and not at all by nucleotide diphosphates.	nucleotide diphosphates	297-320	pyrimidinergic receptor P2Y, G-protein coupled, 4	Mus musculus	208-221
1834361-5	1991	Since nucleotide diphosphates (NDPs) could activate the channel after complete run-down, effects of the drugs on the NDP-induced channel openings were also examined.	nucleotide diphosphates	6-29	norrin	Cavia porcellus	31-34
33903070-2	2021	The nucleoside diphosphate kinase (NDPK) activity of NME1 is well recognized in balancing the intracellular pools of nucleotide diphosphates and triphosphates to regulate cytoskeletal rearrangement and cell motility, endocytosis, intracellular trafficking, and metastasis.	nucleotide diphosphates	117-140	cytidine/uridine monophosphate kinase 2	Homo sapiens	4-33
33903070-2	2021	The nucleoside diphosphate kinase (NDPK) activity of NME1 is well recognized in balancing the intracellular pools of nucleotide diphosphates and triphosphates to regulate cytoskeletal rearrangement and cell motility, endocytosis, intracellular trafficking, and metastasis.	nucleotide diphosphates	117-140	cytidine/uridine monophosphate kinase 2	Homo sapiens	35-39
33903070-2	2021	The nucleoside diphosphate kinase (NDPK) activity of NME1 is well recognized in balancing the intracellular pools of nucleotide diphosphates and triphosphates to regulate cytoskeletal rearrangement and cell motility, endocytosis, intracellular trafficking, and metastasis.	nucleotide diphosphates	117-140	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	53-57
9877232-1	1998	Nucleoside diphosphate kinase (NDP kinase) catalyzes the transfer of terminal phosphate from nucleotide triphosphates (e.g. ATP) to nucleotide diphosphates (e.g. GDP) to yield nucleotide triphosphates (e.g. GTP).	nucleotide diphosphates	132-155	cytidine/uridine monophosphate kinase 1	Rattus norvegicus	0-29
31177779-2	2019	Recently, another hypothesis for the Ga3+ curative effect has been put forward: the metal cation can deactivate the enzyme by entrapping its substrates (nucleotide diphosphates; NDPs) into Ga3+-NDP complexes, lowering the free substrate levels in the cell.	nucleotide diphosphates	153-176	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	189-192