PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8738021-4	1996	Measurements on the C18 column were made using a gradient of acetonitrile, methanol, and ethyl acetate, which is described in detail elsewhere.	ethyl acetate	89-102	Bardet-Biedl syndrome 9	Homo sapiens	20-23
8537826-2	1995	Two independent lines of research led to the finding that the dominant Scutoid (Sco) mutation causes a diminished extracellular electroantennogram response to the odorants ethyl acetate (EtAC) and acetone (AC).	ethyl acetate	172-185	snail	Drosophila melanogaster	71-78
8537826-2	1995	Two independent lines of research led to the finding that the dominant Scutoid (Sco) mutation causes a diminished extracellular electroantennogram response to the odorants ethyl acetate (EtAC) and acetone (AC).	ethyl acetate	172-185	snail	Drosophila melanogaster	80-83
8537826-2	1995	Two independent lines of research led to the finding that the dominant Scutoid (Sco) mutation causes a diminished extracellular electroantennogram response to the odorants ethyl acetate (EtAC) and acetone (AC).	ethyl acetate	187-191	snail	Drosophila melanogaster	71-78
8537826-2	1995	Two independent lines of research led to the finding that the dominant Scutoid (Sco) mutation causes a diminished extracellular electroantennogram response to the odorants ethyl acetate (EtAC) and acetone (AC).	ethyl acetate	187-191	snail	Drosophila melanogaster	80-83
7827262-3	1994	The compound crystallizes in the monoclinic space group P2(1) from methanol/ethyl acetate.	ethyl acetate	76-89	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-61
1556632-3	1992	Electrophysiological recordings from the adult antenna indicate that rdgB is required for normal response in the peripheral olfactory system: some rdgB mutants show a delayed return to the resting potential following stimulation with ethyl acetate vapor.	ethyl acetate	234-247	retinal degeneration B	Drosophila melanogaster	69-73
8329450-2	1993	Groups such as Ac, For, Boc, Z, Mal, Pheac and Alloc always rendered good peptide yields (92% to 99%) either in acetonitrile or in ethyl acetate.	ethyl acetate	131-144	BOC cell adhesion associated, oncogene regulated	Homo sapiens	24-27
1417799-5	1992	The cell growth inhibitory factor produced by these cells was characterized for the physicochemical properties; the cell growth-inhibitory activity was quantitatively recovered in the filtrates of YM-2 membrane (M(r) less than 1,000), resistant to the heat treatments at 56 degrees C for 30 min and 100 degrees C for 5 min, and extractable by ethyl acetate under acid-condition.	ethyl acetate	343-356	metallothionein 3	Mus musculus	9-33
1556632-3	1992	Electrophysiological recordings from the adult antenna indicate that rdgB is required for normal response in the peripheral olfactory system: some rdgB mutants show a delayed return to the resting potential following stimulation with ethyl acetate vapor.	ethyl acetate	234-247	retinal degeneration B	Drosophila melanogaster	147-151
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	ethyl acetate	206-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
1366523-5	1990	In the reaction with the immobilized enzyme (IME) in saturated ethyl acetate, the maximum yield of the precursor of Leu-enkephalin was 68%.	ethyl acetate	63-76	prodynorphin	Homo sapiens	116-130
2029540-1	1991	Affinity labelling of acetylcholinesterase (EC 3.1.1.7, acetylcholine acetylhydrolase) anionic centre with N,N-dimethyl-2-phenylaziridinium ion accelerates the hydrolysis of non-ionic acetic esters by increasing the rate of the enzyme acylation step at least 500-times while the rate of the deacylation step remains unchanged.	ethyl acetate	184-197	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-42
33774797-0	2021	Arsenic-induced uterine apoptotic damage is protected by ethyl acetate fraction of Camellia sinensis (green tea) via Bcl-2-BAX through NF-kappaB regulations in Wistar rats.	ethyl acetate	57-70	BCL2, apoptosis regulator	Rattus norvegicus	117-122
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	ethyl acetate	206-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	ethyl acetate	206-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
17973474-10	2007	In contrast, K2[CoIIH2PtBuuam(OH)] does react with ethyl acetate to produce KOAc; this enhanced reactivity is attributed to the presence of the K+ ions, which can possibly interact with the CoII-OH unit and ester substrate to assist in hydrolysis.	ethyl acetate	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
34929308-9	2022	RESULTS: The ethyl acetate extract of APR showed the strongest tumor inhibitory effect on ER+ and HER2+ breast cancer cells compared to petroleum ether or N-butanol extracts.	ethyl acetate	13-26	epiregulin	Homo sapiens	90-92
34929308-9	2022	RESULTS: The ethyl acetate extract of APR showed the strongest tumor inhibitory effect on ER+ and HER2+ breast cancer cells compared to petroleum ether or N-butanol extracts.	ethyl acetate	13-26	erb-b2 receptor tyrosine kinase 2	Homo sapiens	98-102
34856475-0	2022	Corrigendum to "Cardioprotective activity of ethyl acetate extract of Cinnamomi Ramulus against myocardial ischemia/reperfusion injury in rats via inhibiting NLRP3 inflammasome activation and pyroptosis" (Phytomedicine 93 (2021) 153798).	ethyl acetate	45-58	NLR family, pyrin domain containing 3	Rattus norvegicus	158-163
34673348-0	2021	Cardioprotective activity of ethyl acetate extract of Cinnamomi Ramulus against myocardial ischemia/reperfusion injury in rats via inhibiting NLRP3 inflammasome activation and pyroptosis.	ethyl acetate	29-42	NLR family, pyrin domain containing 3	Rattus norvegicus	142-147
34945535-4	2021	Regarding anti-inflammatory activity, CEE and EtOAc reduced the production of NO and cytokine secretion (PGE2, IL-6, and IL-1beta) but displayed less effect on tumor necrosis factor alpha (TNF-alpha) release in lipopolysaccharide (LPS)-induced RAW 264.7 cells.	ethyl acetate	46-51	interleukin 6	Mus musculus	111-115
34945535-4	2021	Regarding anti-inflammatory activity, CEE and EtOAc reduced the production of NO and cytokine secretion (PGE2, IL-6, and IL-1beta) but displayed less effect on tumor necrosis factor alpha (TNF-alpha) release in lipopolysaccharide (LPS)-induced RAW 264.7 cells.	ethyl acetate	46-51	interleukin 1 alpha	Mus musculus	121-129
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	ethyl acetate	42-55	PDZ and LIM domain 7	Homo sapiens	237-262
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	ethyl acetate	42-55	PDZ and LIM domain 7	Homo sapiens	264-268
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	ethyl acetate	42-55	mitogen-activated protein kinase 1	Homo sapiens	314-317
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	ethyl acetate	42-55	NFKB inhibitor alpha	Homo sapiens	330-342
34673348-4	2021	Whereas, there are no previous investigations in China or abroad has reported the cardioprotective effects and underlying mechanism of the ethyl acetate extract of C. ramulus (CREAE) and its bioactive substance cinnamic acid (CA) in triggering NLRP3 inflammasome activation and subsequent pyroptosis.	ethyl acetate	139-152	NLR family, pyrin domain containing 3	Rattus norvegicus	244-249
34729107-0	2021	Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-alpha-activated COX-2-cPLA2-PGE2 Pathway.	ethyl acetate	49-62	tumor necrosis factor	Homo sapiens	132-141
34231604-0	2021	Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice.	ethyl acetate	68-81	NLR family, pyrin domain containing 3	Mus musculus	14-19
34231604-10	2021	The work demonstrated that the ethyl acetate fraction of Bungeanum ameliorated cognitive deficits, and its effects may be related to ameliorating oxidative stress and suppressing the NLRP3 inflammasome pathway and GSDMD-mediated pyroptosis in aging mice.	ethyl acetate	31-44	NLR family, pyrin domain containing 3	Mus musculus	183-188
34231604-10	2021	The work demonstrated that the ethyl acetate fraction of Bungeanum ameliorated cognitive deficits, and its effects may be related to ameliorating oxidative stress and suppressing the NLRP3 inflammasome pathway and GSDMD-mediated pyroptosis in aging mice.	ethyl acetate	31-44	gasdermin D	Mus musculus	214-219
34829556-4	2021	In vitro anti-inflammatory experiments showed that the ethyl acetate extract of PS and PL (PSE and PLE, respectively) could significantly inhibit the proliferation of concanavalin A (Con A)-activated lymphocytes.	ethyl acetate	55-68	perinatal lethality	Mus musculus	99-102
34847724-11	2021	The acid-hydrolyzed BMF ethyl acetate extracts (BMFE) strongly induced the expression of uncoupling protein 1 (Ucp1) and other thermogenic genes in C3H10T1/2 adipocytes.	ethyl acetate	24-37	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	111-115
34729107-0	2021	Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-alpha-activated COX-2-cPLA2-PGE2 Pathway.	ethyl acetate	49-62	phospholipase A2 group IVA	Homo sapiens	158-163
34684679-6	2021	MeOH extract, EtOAc fraction, and 1-3 suppressed NO formation in LPS-stimulated RAW 264.7 cells and decreased iNOS and COX-2 expression.	ethyl acetate	14-19	nitric oxide synthase 2, inducible	Mus musculus	110-114
34684679-6	2021	MeOH extract, EtOAc fraction, and 1-3 suppressed NO formation in LPS-stimulated RAW 264.7 cells and decreased iNOS and COX-2 expression.	ethyl acetate	14-19	cytochrome c oxidase II, mitochondrial	Mus musculus	119-124
34460260-6	2021	The ethyl acetate fraction and CAFT were found to reduce BACE1 gene expression and are promissory PPARgamma and PGC-1alpha natural agonists.	ethyl acetate	4-17	beta-secretase 1	Sus scrofa	57-62
34630074-5	2021	Interestingly, gracillin, a component from the ethyl acetate extraction of Rhizoma Paridis, was identified to induce the expression of TIPE2 and inhibit the cell proliferation in gastric cancer BGC-823 cells.	ethyl acetate	47-60	TNF alpha induced protein 8 like 2	Homo sapiens	135-140
34385108-3	2021	Ethyl acetate (EtOAc) fraction showed the highest alpha-amylase, beta-glucosidase, and lipase inhibition effect.	ethyl acetate	0-13	lipase G, endothelial type	Rattus norvegicus	87-93
34385108-3	2021	Ethyl acetate (EtOAc) fraction showed the highest alpha-amylase, beta-glucosidase, and lipase inhibition effect.	ethyl acetate	15-20	lipase G, endothelial type	Rattus norvegicus	87-93
34460260-6	2021	The ethyl acetate fraction and CAFT were found to reduce BACE1 gene expression and are promissory PPARgamma and PGC-1alpha natural agonists.	ethyl acetate	4-17	peroxisome proliferator activated receptor gamma	Sus scrofa	98-107
34460260-6	2021	The ethyl acetate fraction and CAFT were found to reduce BACE1 gene expression and are promissory PPARgamma and PGC-1alpha natural agonists.	ethyl acetate	4-17	PPARG coactivator 1 alpha	Sus scrofa	112-122
34149894-7	2021	The water isolated site (WA) and ethyl acetate isolated site (EA) significantly reversed complete Freund"s adjuvant (CFA)-induced changes in the levels of NO, IL-6, TNF-alpha, IgG and IFN-gamma, while the n-butanol isolated site (NB) only reversed the changes in IL-6 and IgG contents.	ethyl acetate	33-46	interleukin 6	Rattus norvegicus	159-163
34369953-0	2021	Correction: Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice.	ethyl acetate	80-93	NLR family, pyrin domain containing 3	Mus musculus	26-31
34369953-1	2021	Correction for "Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice" by Meihuan Zhao et al., Food Funct., 2021, DOI: 10.1039/D1FO00876E.	ethyl acetate	84-97	NLR family, pyrin domain containing 3	Mus musculus	30-35
34375116-7	2021	Thus, TFs may attribute to the accumulation of hexanal and ethyl acetate by regulating the expression of LOX pathway-related genes.	ethyl acetate	59-72	probable linoleate 9S-lipoxygenase 5	Malus domestica	105-108
34392635-17	2021	CONCLUSIONS: The ethylacetate extract of C. alismifolium has beneficial effects in alleviating microvascular complications of diabetes through the inhibition of oxidative stress and aldose reductase in diabetic rats.	ethyl acetate	17-29	aldo-keto reductase family 1 member B1	Rattus norvegicus	182-198
34451703-9	2021	The DPPH free radical and alpha-glucosidase inhibitions was highest in the leaf ethyl acetate fraction, with IC50 of 6.39 and 4.93 microg/mL, respectively, while the leaf methanol crude extract and butanol fraction exhibited the highest FRAP with 82.95 and 82.17 mmol Fe (II)/g extract.	ethyl acetate	80-93	sucrase-isomaltase	Homo sapiens	26-43
34556115-7	2021	Furthermore, the ethyl acetate extracts effectively inhibited NO and TNF-alpha and proved to be comparable to diclofenac at some concentrations.	ethyl acetate	17-30	tumor necrosis factor	Homo sapiens	69-78
34149894-7	2021	The water isolated site (WA) and ethyl acetate isolated site (EA) significantly reversed complete Freund"s adjuvant (CFA)-induced changes in the levels of NO, IL-6, TNF-alpha, IgG and IFN-gamma, while the n-butanol isolated site (NB) only reversed the changes in IL-6 and IgG contents.	ethyl acetate	33-46	tumor necrosis factor	Rattus norvegicus	165-174
34149894-7	2021	The water isolated site (WA) and ethyl acetate isolated site (EA) significantly reversed complete Freund"s adjuvant (CFA)-induced changes in the levels of NO, IL-6, TNF-alpha, IgG and IFN-gamma, while the n-butanol isolated site (NB) only reversed the changes in IL-6 and IgG contents.	ethyl acetate	33-46	interferon gamma	Rattus norvegicus	184-193
34149894-7	2021	The water isolated site (WA) and ethyl acetate isolated site (EA) significantly reversed complete Freund"s adjuvant (CFA)-induced changes in the levels of NO, IL-6, TNF-alpha, IgG and IFN-gamma, while the n-butanol isolated site (NB) only reversed the changes in IL-6 and IgG contents.	ethyl acetate	33-46	interleukin 6	Rattus norvegicus	263-267
34299238-9	2021	The ethyl acetate extracts substantially depressed cholinesterase enzymes (4.49 and 12.26 mg galantamine equivalent/g extract against AChE and BChE, respectively) and alpha-amylase enzyme (1.04 mmol acarbose equivalent/g extract).	ethyl acetate	4-17	butyrylcholinesterase	Homo sapiens	51-65
34299522-4	2021	We aim to tackling this issue by developing two synthetic procedures for MSN size modulation, performed in homogenous aqueous/ethanol solution or two-phase aqueous/ethyl acetate system.	ethyl acetate	164-177	moesin	Mus musculus	73-76
34299238-9	2021	The ethyl acetate extracts substantially depressed cholinesterase enzymes (4.49 and 12.26 mg galantamine equivalent/g extract against AChE and BChE, respectively) and alpha-amylase enzyme (1.04 mmol acarbose equivalent/g extract).	ethyl acetate	4-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
34299238-9	2021	The ethyl acetate extracts substantially depressed cholinesterase enzymes (4.49 and 12.26 mg galantamine equivalent/g extract against AChE and BChE, respectively) and alpha-amylase enzyme (1.04 mmol acarbose equivalent/g extract).	ethyl acetate	4-17	butyrylcholinesterase	Homo sapiens	143-147
34122065-0	2021	The Ethyl Acetate Extract From Celastrus orbiculatus Promotes Apoptosis of Gastric Cancer Cells Through Mitochondria Regulation by PHB.	ethyl acetate	4-17	prohibitin	Mus musculus	131-134
34345601-5	2021	Previous studies revealed the potency of Melia"s ethanolic extract and ethyl acetate fractions as anticancer; furthermore, this study aimed to resolve possible ER-alpha antagonist"s mechanism and safety from M. azedarach leaves ethyl acetate fraction contents.	ethyl acetate	71-84	estrogen receptor 1	Homo sapiens	160-168
34345601-5	2021	Previous studies revealed the potency of Melia"s ethanolic extract and ethyl acetate fractions as anticancer; furthermore, this study aimed to resolve possible ER-alpha antagonist"s mechanism and safety from M. azedarach leaves ethyl acetate fraction contents.	ethyl acetate	228-241	estrogen receptor 1	Homo sapiens	160-168
34209783-7	2021	Moreover, the antioxidant activity of ethyl acetate extract of A. ochraceus (1000 microg mL-1) at 15 and 30% seawater was 95.83 +- 1.25 and 98.33 +- 0.57%, respectively.	ethyl acetate	38-51	L1 cell adhesion molecule	Mus musculus	89-93
34275853-8	2021	COX-2 inhibition was calculated which was high in RME (68.69%), ethyl acetate (56.52%), aqueous (55.21%) and chloroform fraction (53.47%).	ethyl acetate	64-77	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5
35601543-0	2022	Unnatural Amino Acid: 4-Aminopyrazolonyl Amino Acid Comprising Tri-Peptides Forms Organogel With Co-Solvent (EtOAc:Hexane).	ethyl acetate	109-114	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	63-66
34173085-8	2021	Moreover, this study also indicated that ACS1 played a more important role in increasing the acetic acid tolerance of yeast, while ACS2 contributed to the synthesis of cytosol acetyl-CoA, thereby facilitating the production of ethyl-acetate during fermentation.	ethyl acetate	227-240	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	41-45
34173085-8	2021	Moreover, this study also indicated that ACS1 played a more important role in increasing the acetic acid tolerance of yeast, while ACS2 contributed to the synthesis of cytosol acetyl-CoA, thereby facilitating the production of ethyl-acetate during fermentation.	ethyl acetate	227-240	acetate--CoA ligase ACS2	Saccharomyces cerevisiae S288C	131-135
34257694-8	2021	Our results showed that the ethyl acetate fraction (EAf2) from RTL significantly increased glucose uptake and suppressed lipid accumulation in TNF-alpha plus OA-treated FL83B cells.	ethyl acetate	28-41	ELL associated factor 2	Mus musculus	52-56
34257694-8	2021	Our results showed that the ethyl acetate fraction (EAf2) from RTL significantly increased glucose uptake and suppressed lipid accumulation in TNF-alpha plus OA-treated FL83B cells.	ethyl acetate	28-41	tumor necrosis factor	Mus musculus	143-152
35337920-20	2022	The gene and protein levels of TRPA1 and TJs were corrected (p < 0.05, p < 0.01); the effects on the HPMHD high-dose and ethyl acetate extract groups were particularly remarkable.	ethyl acetate	121-134	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	31-36
35633550-0	2022	The Ethyl Acetate Fraction of Marine Sponge Stylissa carteri Induces Breast Cancer Cell Death via Upregulation of Mcl-1S: an In vitro Study.	ethyl acetate	4-17	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	114-120
35470590-5	2022	More strikingly, this solvent-induced transformation could realize the physical performance optimization in the orthorhombic phase (orth-I-OA, obtained from ethanol) with a stronger second harmonic generation (SHG) response, greater piezoelectric coefficient d33 of 5 pC N-1 , and larger spontaneous polarization (Ps ) of 3.43 microC cm-2 than those of monoclinic one (mono-I-OA, obtained from ethyl acetate).	ethyl acetate	394-407	potassium voltage-gated channel subfamily A member 5	Homo sapiens	268-274
35051601-0	2022	Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1Rbeta/PI3K/Akt signaling pathway.	ethyl acetate	11-24	thymoma viral proto-oncogene 1	Mus musculus	157-160
35481086-4	2022	The results showed that the dichloromethane and ethyl acetate fractions showed the highest antioxidant activities, with 84.78 and 86.96% DPPH scavenging at 0.10 mug mL-1.	ethyl acetate	48-61	L1 cell adhesion molecule	Mus musculus	165-169
35447106-10	2022	Ethyl acetate was found to be the optimum cosolvent, improving the loading efficiency of anti-CD47 in poly(lactic-co-glycolic acid), PLGA, nanoparticles to 90% or higher, and the antibody was found to retain its activity after being released from nanoparticles.	ethyl acetate	0-13	CD47 molecule	Homo sapiens	94-98
35449913-1	2022	The reaction of the uranium(IV) halides UCl4, UBr4, or UI4 with ethyl acetate (EtOAc) leads to the formation of the complexes (UX3(EtOAc)4)(UX5(EtOAc)) (X = Cl, Br) or (UI4(EtOAc)3).	ethyl acetate	64-77	ubiquitin protein ligase E3 component n-recognin 4	Homo sapiens	46-50
35449913-1	2022	The reaction of the uranium(IV) halides UCl4, UBr4, or UI4 with ethyl acetate (EtOAc) leads to the formation of the complexes (UX3(EtOAc)4)(UX5(EtOAc)) (X = Cl, Br) or (UI4(EtOAc)3).	ethyl acetate	79-84	ubiquitin protein ligase E3 component n-recognin 4	Homo sapiens	46-50
35449913-1	2022	The reaction of the uranium(IV) halides UCl4, UBr4, or UI4 with ethyl acetate (EtOAc) leads to the formation of the complexes (UX3(EtOAc)4)(UX5(EtOAc)) (X = Cl, Br) or (UI4(EtOAc)3).	ethyl acetate	173-178	ubiquitin protein ligase E3 component n-recognin 4	Homo sapiens	46-50
35449913-2	2022	Thus, both UCl4 and UBr4 show self-ionization in ethyl acetate to a distorted pentagonal bipyramidal (UX3(EtOAc)4)+ cation and a distorted octahedral (UX5(EtOAc))- anion.	ethyl acetate	49-62	ubiquitin protein ligase E3 component n-recognin 4	Homo sapiens	20-24
35150233-5	2022	Alkaline phosphatase activity and OCN level in the ethyl acetate extracts of ume-treated extracts were significantly increased in preosteoblast MC3T3-E1 cells compared with the control group.	ethyl acetate	51-64	bone gamma-carboxyglutamate protein	Homo sapiens	34-37
34991410-7	2022	RESULTS: Ethyl acetate and n-butanol fractions of D. roxburghiana were strongly active against NFkappaB with IC50 of 16.6 +- 1.3 and 8.4 +- 0.7 microg/ml respectively with 100% survival.	ethyl acetate	9-22	nuclear factor kappa B subunit 1	Homo sapiens	95-103
35180341-2	2022	Here we unveil the spin conversion efficiency in the polarization transfer between parahydrogen-derived protons and 13C nuclei of an ethyl acetate biomolecule, formed by the homogeneous hydrogenation of vinyl acetate with parahydrogen, obtained by applying constant-adiabaticity sweep profiles at ultralow magnetic fields.	ethyl acetate	133-146	spindlin 1	Homo sapiens	19-23
35214846-4	2022	In this study, the ethyl-acetate extract (at a concentration of 250 microg/mL) exhibited the greatest inhibitory effect against AChE with significant inhibition of 75%, comparable to the inhibitor galanthamine with an inhibition of 88%.	ethyl acetate	19-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
35203806-4	2022	Bee bread extracts (distilled water, ethanol, methanol, diethyl ether, and ethyl acetate) have been proven to have antioxidant, antifungal, antibacterial, and antitumoral activities, and they can also inhibit alpha-amylase and angiotensin I-converting enzyme in vitro.	ethyl acetate	75-88	angiotensin I converting enzyme	Homo sapiens	227-258
35187077-2	2021	The A. millefolium was extracted and the ethyl acetate fraction was found to be the phenolic-rich fraction (PRF) containing 14.72 +- 2.39 mg gallic acid equivalent (GAE)/g dry weight (DM).	ethyl acetate	41-54	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	108-111
35044248-17	2022	MeOH and EtOAc extracts, as well as the bioactive compounds reversed the toxic effect of dexamethasone by increasing the cell viability, SIRT3 protein expression but reducing the ROS, autophagy and apoptosis.	ethyl acetate	9-14	sirtuin 3	Homo sapiens	137-142
35101006-10	2022	RT-PCR results showed that the expression of Bax mRNA was up-regulate by the middle(2500 mug/ml) and high(3000 mug/ml) dose groups of ethyl acetate extract.	ethyl acetate	134-147	BCL2 associated X, apoptosis regulator	Homo sapiens	45-48
35101006-11	2022	The expression of Caspase-3 mRNA was up-regulated by the low(2000 mug/ml), medium(2500 mug/ml) and high(3000 mug/ml) dose groups of ethyl acetate extract.	ethyl acetate	132-145	caspase 3	Homo sapiens	18-27
35101006-12	2022	The expression of Bcl-2 mRNA was down-regulated by the high(3000 mug/ml) dose group of ethyl acetate extract.	ethyl acetate	87-100	BCL2 apoptosis regulator	Homo sapiens	18-23
35056677-4	2022	According to the A, B, C, and D antioxidant activity assays, the ethyl acetate phase was the strongest with low IC50 values of 0.169 +- 0.01 mg/mL, 0.289 +- 0.01 mg/mL, 0.372 +- 0.01 mg/mL, and 1.029 +- 0.03 mg/mL, respectively, confirming high antioxidant activity.	ethyl acetate	65-78	thrombopoietin	Mus musculus	144-146
35056677-4	2022	According to the A, B, C, and D antioxidant activity assays, the ethyl acetate phase was the strongest with low IC50 values of 0.169 +- 0.01 mg/mL, 0.289 +- 0.01 mg/mL, 0.372 +- 0.01 mg/mL, and 1.029 +- 0.03 mg/mL, respectively, confirming high antioxidant activity.	ethyl acetate	65-78	thrombopoietin	Mus musculus	165-167
35056677-4	2022	According to the A, B, C, and D antioxidant activity assays, the ethyl acetate phase was the strongest with low IC50 values of 0.169 +- 0.01 mg/mL, 0.289 +- 0.01 mg/mL, 0.372 +- 0.01 mg/mL, and 1.029 +- 0.03 mg/mL, respectively, confirming high antioxidant activity.	ethyl acetate	65-78	thrombopoietin	Mus musculus	186-188
35056677-4	2022	According to the A, B, C, and D antioxidant activity assays, the ethyl acetate phase was the strongest with low IC50 values of 0.169 +- 0.01 mg/mL, 0.289 +- 0.01 mg/mL, 0.372 +- 0.01 mg/mL, and 1.029 +- 0.03 mg/mL, respectively, confirming high antioxidant activity.	ethyl acetate	65-78	thrombopoietin	Mus musculus	211-213
2721786-2	1989	Acrylamide was extracted into ethyl acetate after derivatization by bromination to 2,3-dibromopropionamide (2,3-DBPA).	ethyl acetate	30-43	Y-box binding protein 3	Homo sapiens	112-116
35164229-3	2022	Ethyl acetate (ARE) and methanol (ARM) extracts significantly decreased mRNA levels of IL-6, TNF-alpha, MCP-1, COX-2, and iNOS.	ethyl acetate	0-13	interleukin 6	Mus musculus	87-91
3349606-1	1988	The profile of organic acids in plasma of patients with a deficiency of medium-chain acyl-CoA dehydrogenase (EC 1.3.99.3) was determined by gas-liquid chromatography of trimethylsilylated derivatives of the acids isolated by ethyl acetate extraction.	ethyl acetate	225-238	acyl-CoA dehydrogenase medium chain	Homo sapiens	72-107
4016732-4	1985	At low cell density, the active variant TAOc1Bprc1 resembled the weakly active Bprc1 in accumulating a low amount of ethyl acetate-soluble metabolites in the medium while, at high cell density, TAOc1Bprc1 resembled the parent clone Hepa-1c1c7 and the highly active variant MUL12.	ethyl acetate	117-130	protein regulator of cytokinesis 1	Mus musculus	40-50
2445051-13	1987	Gas chromatography-mass spectrometry of an ethyl acetate extract of the alpha 2u-globulin-containing fractions of TMP-treated male rat kidney 116,000g supernatant identified 2,4,4-trimethyl-2-pentanol as the only bound metabolite to alpha 2u-globulin.	ethyl acetate	43-56	alpha2u globulin	Rattus norvegicus	72-89
2445051-13	1987	Gas chromatography-mass spectrometry of an ethyl acetate extract of the alpha 2u-globulin-containing fractions of TMP-treated male rat kidney 116,000g supernatant identified 2,4,4-trimethyl-2-pentanol as the only bound metabolite to alpha 2u-globulin.	ethyl acetate	43-56	alpha2u globulin	Rattus norvegicus	233-250
3689496-2	1987	A 1-ml plasma or urine sample is made alkaline with a carbonate buffer (pH 9.8) and extracted with 20% ethyl acetate in n-heptane.	ethyl acetate	103-116	BCL2 related protein A1	Homo sapiens	0-3
6501968-6	1984	The sample extracted with ethyl acetate was subjected to Bio-Rad AG1-X2 column, thin layer chromatography and co-crystallization to constant specific activity and 3H/14C ratio.	ethyl acetate	26-39	NBPF member 10	Homo sapiens	65-68
6527248-2	1984	A 1-mL plasma sample is made alkaline with a carbonate buffer (pH 9.8) and extracted with 20% ethyl acetate in n-heptane.	ethyl acetate	94-107	BCL2 related protein A1	Homo sapiens	0-3
6235299-4	1984	E1,E2 and E3 produced were decided by submission to extraction with ethyl acetate, Bio-Rad AG1-X2 resin column chromatography, thin layer chromatography and then co-crystallization to constant specific activity and the 3H/14C ratio.	ethyl acetate	68-81	small nucleolar RNA, H/ACA box 73A	Homo sapiens	0-12
6485554-4	1984	With the solvent ethylacetat/tert.	ethyl acetate	17-28	telomerase reverse transcriptase	Homo sapiens	29-33
16662730-4	1982	Numerous acidic, butanol-soluble (e.g. ethyl acetate-insoluble) metabolites were observed with retention times on C(18) high performance liquid chromatography radiocounting similar to those of authentic glucosyl conjugates of GA(1) and GA(8), or with retention times where conjugates of GA(20) would be expected to elute.	ethyl acetate	39-52	gibberellin 20-oxidase 1	Zea mays	287-293
6747378-4	1984	Ethyl acetate extract was submitted to Bio-Rad AG1-X2 column chromatography, TLC, and co-crystallization to constant specific activity and 3H/14C ratio.	ethyl acetate	0-13	NBPF member 10	Homo sapiens	47-50
6200488-2	1983	Incubation of a urine sample in the presence of ascorbic acid, glucuronidase and acylase and subsequent extraction with ethyl acetate precedes derivatization to trimethylsilyl compounds, capillary gas chromatographic separation and flame-ionization detection.	ethyl acetate	120-133	aminoacylase 1	Homo sapiens	81-88
6826683-2	1983	The methylated compounds are then reacted with Dns chloride, and the Dns derivatives are extracted into ethyl acetate, isolated by thin-layer chromatography and quantified by liquid scintillation spectrometry.	ethyl acetate	104-117	dysplastic nevus syndrome	Homo sapiens	69-72
6171566-5	1981	Partially purified PGF-A was soluble in 80% ethanol and insoluble in chloroform or ethyl acetate.	ethyl acetate	83-96	placental growth factor	Homo sapiens	19-22
7347821-3	1981	A significant difference was evidenced between AST and ALT levels in two firms, chiefly attributable to the quantity and quality of the substances utilized in the two technological cycles: trichloroethylene, chromium, sulphuric acid, mineral oils, ammonia, N-hexane, pentanes acetone, ciclo hexane, methanol, ethyl acetate, isopropyl acetate, toluene, methylene chloride.	ethyl acetate	309-322	solute carrier family 17 member 5	Homo sapiens	47-50
7310817-1	1981	Hydrogenolysis of 3-(benzyloxy)cyclophosphamide (10) using Pd/C catalyst and ethyl acetate as solvent leads to the formation of 3-hydroxycyclophosphamide (3, approximately 20%) and cyclophosphamide (1, approximately 10%), accompanied by regioselective hydrogen-exchange reactions at the C-4 and C-5 positions in 3 and 1.	ethyl acetate	77-90	complement component 4B (Chido blood group)	Mus musculus	287-290
7310817-1	1981	Hydrogenolysis of 3-(benzyloxy)cyclophosphamide (10) using Pd/C catalyst and ethyl acetate as solvent leads to the formation of 3-hydroxycyclophosphamide (3, approximately 20%) and cyclophosphamide (1, approximately 10%), accompanied by regioselective hydrogen-exchange reactions at the C-4 and C-5 positions in 3 and 1.	ethyl acetate	77-90	hemolytic complement	Mus musculus	295-298
7341524-4	1981	The synthesis of [17O]-Gly-Ala, [17O]-Gly-Leu and [17O]-Gly-Glu by DCC/HBT mediated coupling of Boc-Gly-[17O]-alpha-COOH with amino acid-O-t-butyl esters followed by deprotection with HCl/EtOAc proceeded without undue loss of the isotope.	ethyl acetate	188-193	DCC netrin 1 receptor	Homo sapiens	67-70
222502-4	1979	After reaction of 10 microL of untreated serum with the angiotensin-converting enzyme substrate analog hippuryl-L-histidyl-L-leucine, the hippuric acid produced is extracted into ethyl acetate and quantitated, relative to an added internal standard, by liquid chromatography.	ethyl acetate	179-192	angiotensin I converting enzyme	Homo sapiens	56-85
521412-2	1979	Ethyl acetate extracts of milk samples which had been spiked with T-2 toxin were purified by thin layer chromatography and derivatized with N,O-bis(trimethylsilyl)acetamide to produce the T-2 toxin trimethylsilyl ether (T-2 toxin-TMS).	ethyl acetate	0-13	solute carrier family 25 member 5	Homo sapiens	188-191
521412-2	1979	Ethyl acetate extracts of milk samples which had been spiked with T-2 toxin were purified by thin layer chromatography and derivatized with N,O-bis(trimethylsilyl)acetamide to produce the T-2 toxin trimethylsilyl ether (T-2 toxin-TMS).	ethyl acetate	0-13	solute carrier family 25 member 5	Homo sapiens	66-69
521412-2	1979	Ethyl acetate extracts of milk samples which had been spiked with T-2 toxin were purified by thin layer chromatography and derivatized with N,O-bis(trimethylsilyl)acetamide to produce the T-2 toxin trimethylsilyl ether (T-2 toxin-TMS).	ethyl acetate	0-13	solute carrier family 25 member 5	Homo sapiens	188-191
43840-2	1979	HCl(Asc, aminosuccinyl), which transformed partially to cyclo[Leu-Asp(Phe-NH2)] during its purification by column chromatography on silica gel with a mixture of ethyl acetate/pyridine/acetic acid/water = 60:20:6:11, i.e. in neutral medium.	ethyl acetate	161-174	PYD and CARD domain containing	Homo sapiens	4-7
1112934-2	1975	Treatment with an enzyme preparation (Glusulase) containing both beta-glucuronidase and sulfatase activity, rendered extractable over 95% of the radioactivity recovered from urine with diethyl ether (estrogens) and ethyl acetate (corticoids).	ethyl acetate	215-228	arylsulfatase family member H	Homo sapiens	88-97
33939580-3	2021	In alpha-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 microM, as compared with that of the positive control acarbose (249 microM).	ethyl acetate	43-48	sucrase-isomaltase	Homo sapiens	3-20
5808314-9	1969	When bile and urine samples were hydrolysed successively by beta-glucuronidase, cold acid and hot acid, most of the radioactivity was converted into substances not extractable from neutral aqueous solution by ethyl acetate-ether.	ethyl acetate	209-222	glucuronidase beta	Felis catus	60-78
33620670-7	2021	Based on the preliminary investigation that ethyl acetate and ethanol extracts have potent effects against insulin resistance on zebrafish larvae, five compounds were isolated from two fractions following: resveratrol, piceatannol, dihydropiceatannol, chrysophanol, and emodin.	ethyl acetate	44-57	preproinsulin	Danio rerio	107-114
34056617-5	2021	We compare them with previous data for PEG/PEO in water and PDMS in ethyl acetate.	ethyl acetate	68-81	progestagen associated endometrial protein	Homo sapiens	39-42
33395575-6	2021	RESULTS: The methanolic and ethyl acetate extracts inhibited CYP2B6 with IC50s 79.16 and 57.96 mug/ml respectively, while none of the extracts had any effect on rifampicin metabolism or showed time-dependant inhibition (TDI).	ethyl acetate	28-41	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	61-67
33599060-1	2021	The synthetic peptide Z-Gly-Aib-Gly-Aib-Gly-Aib-OtBu was crystallized from a mixture of ethyl acetate and n-hexane.	ethyl acetate	88-101	ANIB1	Homo sapiens	28-31
33599060-1	2021	The synthetic peptide Z-Gly-Aib-Gly-Aib-Gly-Aib-OtBu was crystallized from a mixture of ethyl acetate and n-hexane.	ethyl acetate	88-101	ANIB1	Homo sapiens	36-39
33599060-1	2021	The synthetic peptide Z-Gly-Aib-Gly-Aib-Gly-Aib-OtBu was crystallized from a mixture of ethyl acetate and n-hexane.	ethyl acetate	88-101	ANIB1	Homo sapiens	36-39
33622532-8	2021	Antifungal potential of hexane fraction exhibited high inhibitory action against Sclerotium rolfsii (139.2 mug mL-1) whereas ethyl acetate fraction was highly effective against Sclerotinia sclerotiorum (112.1 mug mL-1).	ethyl acetate	125-138	L1 cell adhesion molecule	Mus musculus	213-217
33881683-1	2021	This study aims to investigate the activity of n-hexane, ethyl acetate and butanol fractions obtained from Arrabidaea chica Verlot against MIA-induced osteoarthritis (OA).	ethyl acetate	57-70	MIA SH3 domain containing	Rattus norvegicus	139-142
33739841-1	2021	Under the reaction conditions of Pd(PPh3)4 (2.5 mol %) and PPh3 (10 mol %) in EtOAc at 60  C, the formal (5 + 6) cycloaddition of vinylethylene carbonates with isatoic anhydrides proceeded smoothly and furnished medium-sized N,O-containing heterocycles in reasonable chemical yields.	ethyl acetate	78-83	protein phosphatase 4 catalytic subunit	Homo sapiens	36-40
33739841-1	2021	Under the reaction conditions of Pd(PPh3)4 (2.5 mol %) and PPh3 (10 mol %) in EtOAc at 60  C, the formal (5 + 6) cycloaddition of vinylethylene carbonates with isatoic anhydrides proceeded smoothly and furnished medium-sized N,O-containing heterocycles in reasonable chemical yields.	ethyl acetate	78-83	protein phosphatase 4 catalytic subunit	Homo sapiens	59-63
33152437-12	2021	RESULTS: EtOAc (0.1 to 10 mg/kg) of S. circinnata Cav.	ethyl acetate	9-14	caveolin 1, caveolae protein	Mus musculus	50-53
33573582-7	2021	The ethyl acetate extract showed a significant antioxidant activity (P<0.01) in both DPPH method (70.87 %) and H2O2 method (73.58%) at 200 microg mL-1 .	ethyl acetate	4-17	L1 cell adhesion molecule	Mus musculus	146-150
33576609-3	2021	ATF1 coding AATase was coexpressed in expression cassettes of ACS1/ACS2 and ALD6 to promote the carbon flux toward ethyl acetate from acetyl-CoA.	ethyl acetate	115-128	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	0-4
33576609-3	2021	ATF1 coding AATase was coexpressed in expression cassettes of ACS1/ACS2 and ALD6 to promote the carbon flux toward ethyl acetate from acetyl-CoA.	ethyl acetate	115-128	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	62-66
33576609-3	2021	ATF1 coding AATase was coexpressed in expression cassettes of ACS1/ACS2 and ALD6 to promote the carbon flux toward ethyl acetate from acetyl-CoA.	ethyl acetate	115-128	acetate--CoA ligase ACS2	Saccharomyces cerevisiae S288C	67-71
33576609-3	2021	ATF1 coding AATase was coexpressed in expression cassettes of ACS1/ACS2 and ALD6 to promote the carbon flux toward ethyl acetate from acetyl-CoA.	ethyl acetate	115-128	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	76-80
33223115-0	2021	Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway.	ethyl acetate	0-13	Janus kinase 2	Rattus norvegicus	132-135
33223115-0	2021	Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway.	ethyl acetate	0-13	signal transducer and activator of transcription 3	Rattus norvegicus	136-140
33326625-5	2021	The incubation of cells with EtOAc led to depleted level of GSH, SOD, and catalase activities, and elevated levels of malondialdehyde, nitric oxide, and myeloperoxidase as well as apoptotic activities.	ethyl acetate	29-34	superoxide dismutase 1	Homo sapiens	65-68
33326625-5	2021	The incubation of cells with EtOAc led to depleted level of GSH, SOD, and catalase activities, and elevated levels of malondialdehyde, nitric oxide, and myeloperoxidase as well as apoptotic activities.	ethyl acetate	29-34	catalase	Homo sapiens	74-82
33326625-5	2021	The incubation of cells with EtOAc led to depleted level of GSH, SOD, and catalase activities, and elevated levels of malondialdehyde, nitric oxide, and myeloperoxidase as well as apoptotic activities.	ethyl acetate	29-34	myeloperoxidase	Homo sapiens	153-168
33487045-3	2022	Besides, EtOAc and aqueous fractions exhibited the most inhibition of CCl4-induced inflammatory mediators and improving the changes in the histopathological structures of the liver and kidney.	ethyl acetate	9-14	C-C motif chemokine ligand 4	Rattus norvegicus	70-74
33522322-1	2021	Diospyros kaki L.f. fruit and leaves are traditionally used for the treatment of hypertension, angina, internal hemorrhage, antithrombotic and anti-inflammatory effects.In the current study, the protective effects of ethyl acetate (Per-1), n-butanol (Per-2), and aqueous (Per-3) fractions of Diospyros kaki leaves against carbon tetrachloride (CCl4) induced nephrotoxicity in Swiss albino rats were tested.	ethyl acetate	217-230	period circadian regulator 2	Rattus norvegicus	251-256
33522322-1	2021	Diospyros kaki L.f. fruit and leaves are traditionally used for the treatment of hypertension, angina, internal hemorrhage, antithrombotic and anti-inflammatory effects.In the current study, the protective effects of ethyl acetate (Per-1), n-butanol (Per-2), and aqueous (Per-3) fractions of Diospyros kaki leaves against carbon tetrachloride (CCl4) induced nephrotoxicity in Swiss albino rats were tested.	ethyl acetate	217-230	period circadian regulator 3	Rattus norvegicus	272-277
33522322-1	2021	Diospyros kaki L.f. fruit and leaves are traditionally used for the treatment of hypertension, angina, internal hemorrhage, antithrombotic and anti-inflammatory effects.In the current study, the protective effects of ethyl acetate (Per-1), n-butanol (Per-2), and aqueous (Per-3) fractions of Diospyros kaki leaves against carbon tetrachloride (CCl4) induced nephrotoxicity in Swiss albino rats were tested.	ethyl acetate	217-230	C-C motif chemokine ligand 4	Rattus norvegicus	344-348
33505936-5	2020	In particular, the EPSP ethyl acetate (EtOAc) fraction exhibited high antioxidant, antidiabetic, and angiotensin I-converting enzyme inhibitory activities.	ethyl acetate	24-37	angiotensin I converting enzyme	Homo sapiens	101-132
33505936-5	2020	In particular, the EPSP ethyl acetate (EtOAc) fraction exhibited high antioxidant, antidiabetic, and angiotensin I-converting enzyme inhibitory activities.	ethyl acetate	39-44	angiotensin I converting enzyme	Homo sapiens	101-132
32999131-0	2020	Ethyl acetate fraction of flavonoids from Polygonum hydropiper L. modulates pseudorabies virus-induced inflammation in RAW264.7 cells via the NF-kappaB and MAPK pathways.	ethyl acetate	0-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
33238963-11	2020	The ethyl acetate fraction of V. leopoldi (0.87 mug/mL) significantly inhibited tumor necrosis factor-alpha-induced nuclear factor-kappa B translocation to the nucleus.	ethyl acetate	4-17	tumor necrosis factor	Homo sapiens	80-107
33169760-1	2020	Reaction of Co(NCS)2 and Ni(NCS)2 with 4-tert-butylpyridine in ethyl acetate leads to the formation of mixed crystals of a layered compound with the composition [CoxNi1-x(NCS)2(4-tert-butylpyridine]n.	ethyl acetate	63-76	cytosolic thiouridylase subunit 2	Homo sapiens	12-20
33169760-1	2020	Reaction of Co(NCS)2 and Ni(NCS)2 with 4-tert-butylpyridine in ethyl acetate leads to the formation of mixed crystals of a layered compound with the composition [CoxNi1-x(NCS)2(4-tert-butylpyridine]n.	ethyl acetate	63-76	cytosolic thiouridylase subunit 2	Homo sapiens	25-33
32845350-5	2020	We synthesized tert-butyldimethylsilyl (TBDMS) chitosan which is soluble in a 50:50 solution of ethyl acetate and toluene.	ethyl acetate	96-109	telomerase reverse transcriptase	Homo sapiens	15-19
33335557-4	2020	The aim of this study was to investigate the bioactive compounds in RTL ethyl acetate (EA) fractions by using a glucose uptake assay in TNF-alpha-treated mouse FL83B hepatocytes to discover a mechanism by which to improve IR.	ethyl acetate	72-85	tumor necrosis factor	Mus musculus	136-145
33335557-4	2020	The aim of this study was to investigate the bioactive compounds in RTL ethyl acetate (EA) fractions by using a glucose uptake assay in TNF-alpha-treated mouse FL83B hepatocytes to discover a mechanism by which to improve IR.	ethyl acetate	87-89	tumor necrosis factor	Mus musculus	136-145
32721259-1	2020	Ethanol extract (RET) of Rosa multiflora Thunb flowers and its subfractions in ethylacetate (REA) or n-butanol subfractions (RBT) were reported to have potent antioxidative and anti-inflammatory activities.	ethyl acetate	79-91	ret proto-oncogene	Mus musculus	17-20
31948300-1	2020	In an in vitro screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of Magydaris pastinacea seeds selectively inhibited hCA IX and hCA XII isoforms.	ethyl acetate	122-135	carbonic anhydrase 12	Homo sapiens	208-215
33084650-0	2020	A self-confinement synthesis of a POM-decorated MOF thin film for actively hydrolyzing ethyl acetate.	ethyl acetate	87-100	lysine acetyltransferase 8	Homo sapiens	48-51
32930826-11	2020	GC-MS profile of ethyl acetate extract exposed the occurrence of Bis (2-Ethylhexyl) Phthalate and n-Hexadecanoic acid and shows 100% toxic effect at 24 mg/mL by Artemia nauplii.	ethyl acetate	17-30	Bis protein	Escherichia coli	65-68
32803303-5	2020	Limits of quantitation (LOQ) ranged from 4 to 20 pg muL-1 ethyl acetate (PDMS extract) for pesticides and persistent organic pollutants (POPs).	ethyl acetate	58-71	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	52-57
32678491-5	2020	The ethyl acetate extract of Balanophora involucrata exhibited significant inhibitory activity against neuraminidase with IC50 at 159.5 mug/mL.	ethyl acetate	4-17	neuraminidase 1	Homo sapiens	103-116
33204399-0	2020	Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition.	ethyl acetate	30-43	neuraminidase 1	Homo sapiens	94-107
32717481-7	2020	Furthermore, the ethylacetate 77 gave both submicromolar inhibitory activity and 33-fold selectivity for SENP2 versus SENP5.	ethyl acetate	17-29	SUMO specific peptidase 2	Homo sapiens	105-110
32717481-7	2020	Furthermore, the ethylacetate 77 gave both submicromolar inhibitory activity and 33-fold selectivity for SENP2 versus SENP5.	ethyl acetate	17-29	SUMO specific peptidase 5	Homo sapiens	118-123
32512042-9	2020	And the HepG2 cells induced at the ethyl acetate fraction could up-regulate Bax gene and protein, while down-regulating Bcl-2 gene and protein (P < 0.05) during S phase in a dose-dependent manner.	ethyl acetate	35-48	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79
32512042-9	2020	And the HepG2 cells induced at the ethyl acetate fraction could up-regulate Bax gene and protein, while down-regulating Bcl-2 gene and protein (P < 0.05) during S phase in a dose-dependent manner.	ethyl acetate	35-48	BCL2 apoptosis regulator	Homo sapiens	120-125
32512042-10	2020	In addition, the ethyl acetate site of Larch can also down regulate the expression of ERK, AKT and activate caspase 3, 8 and 9.	ethyl acetate	17-30	mitogen-activated protein kinase 1	Homo sapiens	86-89
32512042-10	2020	In addition, the ethyl acetate site of Larch can also down regulate the expression of ERK, AKT and activate caspase 3, 8 and 9.	ethyl acetate	17-30	AKT serine/threonine kinase 1	Homo sapiens	91-94
32512042-10	2020	In addition, the ethyl acetate site of Larch can also down regulate the expression of ERK, AKT and activate caspase 3, 8 and 9.	ethyl acetate	17-30	caspase 3	Homo sapiens	108-126
33040785-0	2020	Effects of ethyl acetate extract of peony (Paeonia suffruticosa) seed coat on the proliferation and apoptosis of oral squamous carcinoma cells through miR-424-3p/STAT3/Survivin pathway.	ethyl acetate	11-24	signal transducer and activator of transcription 3	Homo sapiens	162-167
33040785-2	2020	This experiment aimed to investigate whether ethyl acetate extract of peony (Paeonia suffruticosa) seed coat could affect the proliferation and apoptosis of oral squamous carcinoma cells by regulating the miR-424-3p/STAT3/Survivin pathway.	ethyl acetate	45-58	signal transducer and activator of transcription 3	Homo sapiens	216-221
33040785-9	2020	Results showed that ethyl acetate extract of peony seed coat could reduce cell proliferation rate and the protein levels of PCNA, Bcl-2, p-STAT3, Survivin and the expression level of miR-424-3p (P<0.05), increase apoptosis rate and the protein level of Bax (P<0.05).	ethyl acetate	20-33	proliferating cell nuclear antigen	Homo sapiens	124-128
33040785-9	2020	Results showed that ethyl acetate extract of peony seed coat could reduce cell proliferation rate and the protein levels of PCNA, Bcl-2, p-STAT3, Survivin and the expression level of miR-424-3p (P<0.05), increase apoptosis rate and the protein level of Bax (P<0.05).	ethyl acetate	20-33	BCL2 apoptosis regulator	Homo sapiens	130-135
33040785-9	2020	Results showed that ethyl acetate extract of peony seed coat could reduce cell proliferation rate and the protein levels of PCNA, Bcl-2, p-STAT3, Survivin and the expression level of miR-424-3p (P<0.05), increase apoptosis rate and the protein level of Bax (P<0.05).	ethyl acetate	20-33	signal transducer and activator of transcription 3	Homo sapiens	139-144
33040785-9	2020	Results showed that ethyl acetate extract of peony seed coat could reduce cell proliferation rate and the protein levels of PCNA, Bcl-2, p-STAT3, Survivin and the expression level of miR-424-3p (P<0.05), increase apoptosis rate and the protein level of Bax (P<0.05).	ethyl acetate	20-33	BCL2 associated X, apoptosis regulator	Homo sapiens	253-256
33040785-11	2020	Transfection of miR-424-3p mimics could significantly reduce the regulatory effect of ethyl acetate extract of peony seed coat on CAL27 cell proliferation, apoptosis and STAT3/Survivin pathway.	ethyl acetate	86-99	signal transducer and activator of transcription 3	Homo sapiens	170-175
33040785-12	2020	It concluded that ethyl acetate extract of peony seed coat could inhibit the activation of the STAT3/Survivin signaling pathway by down-regulating the expression of miR-424-3p, thereby inhibiting the proliferation of oral squamous carcinoma cells and inducing apoptosis.	ethyl acetate	18-31	signal transducer and activator of transcription 3	Homo sapiens	95-100
32967253-5	2020	This study evaluates and compares the technical and economic feasibility of GAA production via bioconversion using either ethyl acetate or alamine in diisobutylkerosene (DIBK) as organic solvents for purification.	ethyl acetate	122-135	alpha glucosidase	Homo sapiens	76-79
32982354-6	2020	Results: GLUT-4 concentration was significantly higher in the membrane fraction of cells treated with ethyl acetate ginger extract in the absence of any inhibitor in comparison with cells treated with this extract in the presence of each of the inhibitors (P-value < 0.05).	ethyl acetate	102-115	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	9-15
32982354-9	2020	Conclusion: Ethyl acetate ginger extract affects the amount of GLUT-4 protein in membrane and cytosolic fractions of C2C12 myoblast cells mostly through AMPK pathway but less via PI3K.	ethyl acetate	12-25	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	63-69
32908528-14	2020	The Streptomyces species-derived ethyl acetate extracts from Nepalese soil demonstrate potential activity against ESBL-producing E. coli.	ethyl acetate	33-46	EsbL	Escherichia coli	114-118
32889401-10	2020	The isolated p-coumaric acid exhibited high ovicidal effect against goat gastrointestinal nematodes (IC50: 0.12 mg mL-1) and can be considered the active substance of the ethyl acetate extract.	ethyl acetate	171-184	L1 cell adhesion molecule	Mus musculus	115-119
32922506-0	2020	Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis.	ethyl acetate	0-13	microRNA 200c	Mus musculus	107-115
32922506-0	2020	Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis.	ethyl acetate	0-13	phosphodiesterase 7B	Mus musculus	116-121
32922506-0	2020	Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis.	ethyl acetate	0-13	CD274 antigen	Mus musculus	122-127
32784977-7	2020	In addition, results of the anti-inflammatory assays showed that the ethyl acetate fraction showed appreciable reductions in the levels of nitric oxide and inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in Raw 264.7 cells.	ethyl acetate	69-82	tumor necrosis factor	Mus musculus	180-189
32784977-7	2020	In addition, results of the anti-inflammatory assays showed that the ethyl acetate fraction showed appreciable reductions in the levels of nitric oxide and inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in Raw 264.7 cells.	ethyl acetate	69-82	interleukin 1 alpha	Mus musculus	191-199
32784977-7	2020	In addition, results of the anti-inflammatory assays showed that the ethyl acetate fraction showed appreciable reductions in the levels of nitric oxide and inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in Raw 264.7 cells.	ethyl acetate	69-82	interleukin 6	Mus musculus	205-209
32317077-5	2020	When the extract and four fractions of H. japonicus were treated respectively in UVB-irradiated Hs68 cells to investigate anti-photoaging effects, the ethyl acetate (EtOAc) fraction showed the strongest inhibitory effect on MMP-1 secretion.	ethyl acetate	151-164	matrix metallopeptidase 1	Homo sapiens	224-229
32468007-0	2020	Effects of an ethyl acetate extract of Daphne altaica stem bark on the cell cycle, apoptosis and expression of PPARgamma in Eca-109 human esophageal carcinoma cells.	ethyl acetate	14-27	peroxisome proliferator activated receptor gamma	Homo sapiens	111-120
32468007-4	2020	The present study aimed to investigate the molecular mechanisms underlying the activity of an ethyl acetate extract of D. altaica (Da-Ea) by assessing its effects on cell morphology, cell apoptosis, cell cycle progression and the expression levels of peroxisome proliferator-activated receptor gamma (PPARgamma) in Eca-109 cells.	ethyl acetate	94-107	peroxisome proliferator activated receptor gamma	Homo sapiens	301-310
32317077-5	2020	When the extract and four fractions of H. japonicus were treated respectively in UVB-irradiated Hs68 cells to investigate anti-photoaging effects, the ethyl acetate (EtOAc) fraction showed the strongest inhibitory effect on MMP-1 secretion.	ethyl acetate	166-171	matrix metallopeptidase 1	Homo sapiens	224-229
31841255-3	2020	The ethyl acetate extract of MP1 was subjected to silica column chromatography followed by LH 20 column chromatography for purification of active metabolites.	ethyl acetate	4-17	pitrilysin metallopeptidase 1	Homo sapiens	29-32
31845053-8	2020	Reduction of myeloperoxidase activity and inflammatory cell infiltration was observed in the paw tissue of mice injected with CFA and treated with EtOAc fraction.	ethyl acetate	147-152	myeloperoxidase	Mus musculus	13-28
30449158-2	2020	Our previous studies showed that the ethyl acetate extraction of Daphne papyracea exhibited an inhibitory effect towards the HCV NS3/4A protease and eight compounds were identified from the extract.	ethyl acetate	37-50	hcv ns3/4a protease	None	125-144
30580622-3	2020	The angiotensin-I converting enzyme (ACE) inhibition test indicated that the ethyl acetate extracts of DRR (DRRE) and PRR (PRRE) show better inhibitory activity.	ethyl acetate	77-90	angiotensin I converting enzyme	Rattus norvegicus	4-35
30580622-3	2020	The angiotensin-I converting enzyme (ACE) inhibition test indicated that the ethyl acetate extracts of DRR (DRRE) and PRR (PRRE) show better inhibitory activity.	ethyl acetate	77-90	angiotensin I converting enzyme	Rattus norvegicus	37-40
30777444-1	2020	Meanwhile, EtOAc and n-BuOH fractions of MeOH extract of P. serpens L. show power activity against H460, HepG2, Hela, and PC9/GR cell lines, and no toxic effects against normal 16HBE cell lines.	ethyl acetate	11-16	proprotein convertase subtilisin/kexin type 9	Homo sapiens	122-125
32534360-0	2020	Ethyl acetate extract of herpetospermum pedunculosum alleviates alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid x receptor and suppressing oxidative stress and inflammation in rats.	ethyl acetate	0-13	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	131-151
32335358-1	2020	Investigation of components of the chloroform-soluble and ethyl acetate-soluble extracts of the aerial parts of Chromolaena odorata L. selected by PCSK9 mRNA expression monitoring assay in HepG2 cells led to the isolation of a new stilbene dimer, (+)-8b-epi-ampelopsin A (1), and 30 known compounds (2-31).	ethyl acetate	58-71	proprotein convertase subtilisin/kexin type 9	Homo sapiens	147-152
32289492-3	2020	Hydrophobic complexes were formed between bovine serum albumin (BSA) and either dodecyl sulfate, cetyl trimethylammonium or 1,2-dipalmitoyl-sn-glycero-3-phosphate applying the organic solvent-free method, Bligh-Dyer method and biphasic metathesis reaction either with ethyl acetate or chloroform as organic phase.	ethyl acetate	268-281	albumin	Homo sapiens	49-62
31931158-9	2020	The ethyl acetate fraction (EAF) inhibited 87.76% of the DPPH radical with an EC50 of 22.94 mug mL-1 and Antioxidant Activity Index of 1.74.	ethyl acetate	4-17	L1 cell adhesion molecule	Mus musculus	96-100
32368636-4	2020	alpha-Glucosidase inhibitory bioassay-guided isolation of the ethyl acetate extract of the leaves of G.cowa resulted in the isolation and identification of 11 compounds.	ethyl acetate	62-75	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
32477135-0	2020	Chinese Dragon"s Blood EtOAc Extract Inhibits Liver Cancer Growth Through Downregulation of Smad3.	ethyl acetate	23-28	SMAD family member 3	Mus musculus	92-97
32319560-6	2020	The present study aimed to investigate the anticancer properties of crude ethyl acetate extracts of B. ovata (BEA) and C. oblongifolius (CEA) in order to explore their underlying mechanisms in breast cancer cell death.	ethyl acetate	74-87	CEA cell adhesion molecule 3	Homo sapiens	137-140
32147838-5	2020	The results showed that EA fraction possesses significant free radical scavenging, alpha-amylase and alpha-glucosidase inhibition properties.	ethyl acetate	24-26	sucrase-isomaltase	Homo sapiens	101-118
31845444-5	2020	When the EtOAc-soluble fraction was administered for 7 days to ob/ob mice, a type 2 diabetes mellitus model, the mice fed with this fraction exhibited a significant decrease in body weight and blood glucose concentrations compared with the mice fed without the fraction.	ethyl acetate	9-14	leptin	Mus musculus	63-65
31845444-5	2020	When the EtOAc-soluble fraction was administered for 7 days to ob/ob mice, a type 2 diabetes mellitus model, the mice fed with this fraction exhibited a significant decrease in body weight and blood glucose concentrations compared with the mice fed without the fraction.	ethyl acetate	9-14	leptin	Mus musculus	66-68
31845444-7	2020	The EtOAc-soluble fraction decreased the interleukin-1beta mRNA expression, as well as hepatic lipid accumulation in hepatocytes.	ethyl acetate	4-9	interleukin 1 beta	Mus musculus	41-58
32280373-6	2020	To select a suitable AAT, the ethyl acetate-forming capacities of Atf1 from Saccharomyces cerevisiae, Eat1 from Kluyveromyces marxianus and Eat1 from Wickerhamomyces anomalus were compared.	ethyl acetate	30-43	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	66-70
31741085-1	2020	The reactive distillation process for the synthesis of n-butyl acetate via transesterification of ethyl acetate with n-butyl alcohol catalyzed by immobilized lipase was simulated and experimentally tested in this work.	ethyl acetate	98-111	PAN0_003d1715	Moesziomyces antarcticus	158-164
32079363-8	2020	The ethyl acetate extract was the most active acetylcholinesterase (4.43 mg galantamine equivalent/g extract) and alpha-glucosidase (mmol acarbose equivalent /g extract) inhibitor.	ethyl acetate	4-17	sucrase-isomaltase	Homo sapiens	114-131
31877366-2	2020	AIM OF THE STUDY: The aim of this study was to isolate and identify the effective antimicrobial components from the ethyl acetate extract of the Ci Li Gen and to investigate its antimicrobial mechanism afterwards.	ethyl acetate	116-129	GEN1 Holliday junction 5' flap endonuclease	Homo sapiens	151-154
31877366-3	2020	MATERIALS AND METHODS: The effective antimicrobial components in the ethyl acetate extract from the Ci Li Gen were isolated by high-performance liquid chromatography (HPLC) and identified by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR).	ethyl acetate	69-82	GEN1 Holliday junction 5' flap endonuclease	Homo sapiens	106-109
32143618-6	2020	Further characterization of the CDD fraction in MCF-7 cells revealed that it could activate the enzymatic activity of various caspases in a statistically significant manner, and induce cleavage of both caspase 7 and poly ADB ribose polymerase (PARP) proteins, but not the ethyl acetate fraction.	ethyl acetate	272-285	natriuretic peptide A	Homo sapiens	32-35
32143618-6	2020	Further characterization of the CDD fraction in MCF-7 cells revealed that it could activate the enzymatic activity of various caspases in a statistically significant manner, and induce cleavage of both caspase 7 and poly ADB ribose polymerase (PARP) proteins, but not the ethyl acetate fraction.	ethyl acetate	272-285	poly(ADP-ribose) polymerase 1	Homo sapiens	244-248
32328140-11	2020	In addition, ethyl acetate fraction at 200 mg/kg decreased the levels of troponin, AST, ALT, and ALP to 0.22 +- 0.02 ng/mL, 137.00 +- 14.30 U/L, 90.33 +- 6.13 U/L, and 166.67 +- 13.50 U/L, respectively, compared with the cyclophosphamide control group.	ethyl acetate	13-26	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	83-86
32045840-2	2020	PURPOSE: This study aims to investigate the effect of the ethyl acetate extract of the dried heartwood of Caesalpinia sappan L. (C-A-E) on induction of apoptosis and promotion of differentiation in vitro and anti-AML activity in vivo.	ethyl acetate	58-71	gap junction protein alpha 8	Homo sapiens	129-134
31585162-16	2020	In AR model, extract from the ethyl acetate layer of 95% ethanol significantly alleviated the AR symptoms in guinea pigs, decreased the serum levels of histamine, INF-gamma, IL-2/4/10, and VCAM-1, and reduced the infiltration of eosinophil in nasal mucosa.	ethyl acetate	30-43	LOW QUALITY PROTEIN: vascular cell adhesion protein 1	Cavia porcellus	189-195
32116723-6	2020	The ethyl acetate extract significantly inhibited alpha-glucosidase activity, and the inhibition potency was equivalent to that of acarbose (p > 0.05).	ethyl acetate	4-17	sucrase isomaltase (alpha-glucosidase)	Mus musculus	50-67
32116723-8	2020	As the n-butanol and ethyl acetate extracts were found to have potent anti-inflammatory and alpha-glucosidase-inhibitory activities, we separated and identified 10 compounds from the extracts.	ethyl acetate	21-34	sucrase isomaltase (alpha-glucosidase)	Mus musculus	92-109
31709710-3	2020	Abundant microporosity and relatively high ionic moieties were obtainable in the ethyl group tethered ionic HCP, bringing remarkable selective CO 2 capture performance with the CO 2 uptake of 3.05 mmol g -1 and the ideal adsorbed solution theory (IAST) CO 2 /N 2 selectivity as high as 363 (273 K, 1 bar).	ethyl acetate	81-86	complement C2	Homo sapiens	143-147
32211102-0	2020	Ethyl acetate extract of sappanwood alleviates experimental atherosclerosis in rats through changes in FGF21 and SREBP-2 expression.	ethyl acetate	0-13	fibroblast growth factor 21	Rattus norvegicus	103-108
32211102-0	2020	Ethyl acetate extract of sappanwood alleviates experimental atherosclerosis in rats through changes in FGF21 and SREBP-2 expression.	ethyl acetate	0-13	sterol regulatory element binding transcription factor 2	Rattus norvegicus	113-120
31709710-3	2020	Abundant microporosity and relatively high ionic moieties were obtainable in the ethyl group tethered ionic HCP, bringing remarkable selective CO 2 capture performance with the CO 2 uptake of 3.05 mmol g -1 and the ideal adsorbed solution theory (IAST) CO 2 /N 2 selectivity as high as 363 (273 K, 1 bar).	ethyl acetate	81-86	complement C2	Homo sapiens	177-181
31709710-3	2020	Abundant microporosity and relatively high ionic moieties were obtainable in the ethyl group tethered ionic HCP, bringing remarkable selective CO 2 capture performance with the CO 2 uptake of 3.05 mmol g -1 and the ideal adsorbed solution theory (IAST) CO 2 /N 2 selectivity as high as 363 (273 K, 1 bar).	ethyl acetate	81-86	complement C2	Homo sapiens	177-181
31746299-0	2020	Ethyl acetate and aqueous fractions of Ziziphus jujuba prevent acute hypertension induced by angiotensin II in rats.	ethyl acetate	0-13	angiotensinogen	Rattus norvegicus	93-107
31746299-9	2020	Comparison the effects of two fractions revealed that both fractions reduced cardiovascular responses induced by AngII but ethyl acetate is more effective than aqueous fraction.	ethyl acetate	123-136	angiotensinogen	Rattus norvegicus	113-118
31609067-5	2019	In vitro study, the ethyl acetate extract (EAE) and butanol extract (BE) of CTC exhibited anti-lipid peroxidation (IC50 : BHA>BE or EAE>ascorbic acid, p<0.05) and alpha-glucosidase inhibitory activity (IC50 : BE>EAE, p<0.05).	ethyl acetate	20-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
31657678-4	2020	The preliminary phytochemical test was conducted for the affirmation of phytoconstituents in the endophytic crude ethyl acetate extract of T. indica (TIM).	ethyl acetate	114-127	Rho guanine nucleotide exchange factor 5	Homo sapiens	150-153
33463938-0	2020	Lipids in an Ethyl Acetate Fraction of Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Reduce Nitric Oxide Production in BV2 Cells via NRF2 and NF-kappaB Pathways.	ethyl acetate	13-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	154-158
33463938-0	2020	Lipids in an Ethyl Acetate Fraction of Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Reduce Nitric Oxide Production in BV2 Cells via NRF2 and NF-kappaB Pathways.	ethyl acetate	13-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	163-172
31185340-10	2019	EA extract showed up-regulation of Bax proapoptotic gene and apoptotic DNA fragmentation activity on highly invasive MDA-MB-231 cells.	ethyl acetate	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	35-38
31728208-12	2019	Despite of significantly high IL-6 levels, the arthritic symptoms waned off which suggested the participation of IL-6 in LC3b-independent autophagy pathway in the extract prepared in ethyl acetate.	ethyl acetate	183-196	microtubule-associated protein 1 light chain 3 beta	Mus musculus	121-125
31683960-7	2019	Treatment of MDA-MB-231 cells with fruit ethyl acetate fraction (RSF EtOAc) increased expression 11of P53, Bax and activation of caspase 3/7.	ethyl acetate	41-54	tumor protein p53	Homo sapiens	102-105
31683960-7	2019	Treatment of MDA-MB-231 cells with fruit ethyl acetate fraction (RSF EtOAc) increased expression 11of P53, Bax and activation of caspase 3/7.	ethyl acetate	41-54	BCL2 associated X, apoptosis regulator	Homo sapiens	107-110
31683960-7	2019	Treatment of MDA-MB-231 cells with fruit ethyl acetate fraction (RSF EtOAc) increased expression 11of P53, Bax and activation of caspase 3/7.	ethyl acetate	41-54	caspase 3	Homo sapiens	129-138
31529418-10	2019	Thus, EtOAc from O. elatus ARs is involved in regulating MAKP and NF-kappaB signaling pathways to inhibit LPS-induced inflammation.	ethyl acetate	6-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
31758521-7	2019	With ethyl acetate vapor addition, the signal intensities of all proteins investigated were significantly increased, including proteins larger than 25 kDa such as carbonic anhydrase II and bovine serum albumin.	ethyl acetate	5-18	carbonic anhydrase 2	Homo sapiens	163-184
31758521-7	2019	With ethyl acetate vapor addition, the signal intensities of all proteins investigated were significantly increased, including proteins larger than 25 kDa such as carbonic anhydrase II and bovine serum albumin.	ethyl acetate	5-18	albumin	Homo sapiens	196-209
31970023-11	2019	Results: Among various fractions of AT, the ethyl acetate fraction of AT (EAT) showed the most significant suppressive effect on the mRNA expression of M2 macrophage markers, including arginase-1, interleukin (IL)-10 and mannose receptor C type 1 (MRC-1), up-regulated by treatment of IL-4 and IL-13.	ethyl acetate	44-57	arginase, liver	Mus musculus	185-195
31970023-11	2019	Results: Among various fractions of AT, the ethyl acetate fraction of AT (EAT) showed the most significant suppressive effect on the mRNA expression of M2 macrophage markers, including arginase-1, interleukin (IL)-10 and mannose receptor C type 1 (MRC-1), up-regulated by treatment of IL-4 and IL-13.	ethyl acetate	44-57	mannose receptor, C type 1	Mus musculus	221-246
31970023-11	2019	Results: Among various fractions of AT, the ethyl acetate fraction of AT (EAT) showed the most significant suppressive effect on the mRNA expression of M2 macrophage markers, including arginase-1, interleukin (IL)-10 and mannose receptor C type 1 (MRC-1), up-regulated by treatment of IL-4 and IL-13.	ethyl acetate	44-57	mannose receptor, C type 1	Mus musculus	248-253
31970023-11	2019	Results: Among various fractions of AT, the ethyl acetate fraction of AT (EAT) showed the most significant suppressive effect on the mRNA expression of M2 macrophage markers, including arginase-1, interleukin (IL)-10 and mannose receptor C type 1 (MRC-1), up-regulated by treatment of IL-4 and IL-13.	ethyl acetate	44-57	interleukin 4	Mus musculus	285-289
31970023-11	2019	Results: Among various fractions of AT, the ethyl acetate fraction of AT (EAT) showed the most significant suppressive effect on the mRNA expression of M2 macrophage markers, including arginase-1, interleukin (IL)-10 and mannose receptor C type 1 (MRC-1), up-regulated by treatment of IL-4 and IL-13.	ethyl acetate	44-57	interleukin 13	Mus musculus	294-299
32419968-6	2020	The ethyl acetate fraction exerted protective effects against CCl4- or H2O2-induced hepatotoxicity via DNA protection, lipid accumulation inhibition, and cell protection, wherein ALT and AST activities in the cell culture solution decreased significantly.	ethyl acetate	4-17	chemokine (C-C motif) ligand 4	Mus musculus	62-66
32419968-6	2020	The ethyl acetate fraction exerted protective effects against CCl4- or H2O2-induced hepatotoxicity via DNA protection, lipid accumulation inhibition, and cell protection, wherein ALT and AST activities in the cell culture solution decreased significantly.	ethyl acetate	4-17	glutamic pyruvic transaminase, soluble	Mus musculus	179-182
32419968-6	2020	The ethyl acetate fraction exerted protective effects against CCl4- or H2O2-induced hepatotoxicity via DNA protection, lipid accumulation inhibition, and cell protection, wherein ALT and AST activities in the cell culture solution decreased significantly.	ethyl acetate	4-17	transmembrane protease, serine 11d	Mus musculus	187-190
31728208-11	2019	On the other hand, a novel LC3b-independent autophagy pathway was observed in mice treated with ethyl acetate extract due to ULK-1 upregulation.	ethyl acetate	96-109	microtubule-associated protein 1 light chain 3 beta	Mus musculus	27-31
31728208-11	2019	On the other hand, a novel LC3b-independent autophagy pathway was observed in mice treated with ethyl acetate extract due to ULK-1 upregulation.	ethyl acetate	96-109	unc-51 like kinase 1	Mus musculus	125-130
31728208-12	2019	Despite of significantly high IL-6 levels, the arthritic symptoms waned off which suggested the participation of IL-6 in LC3b-independent autophagy pathway in the extract prepared in ethyl acetate.	ethyl acetate	183-196	interleukin 6	Mus musculus	113-117
31777585-14	2019	Conclusion: Based on the sequential extraction procedure, our results reveal the inhibitory effect of water eluate fraction of the ethyl acetate extract from dark tea and its synergistic effect with p38 inhibition on the growth of pancreatic cancer cells, in which ID1 is identified as a downstream effector.	ethyl acetate	131-144	inhibitor of DNA binding 1, HLH protein	Homo sapiens	265-268
29663826-1	2019	The objective of this study is to explore the preventive effects of ethyl acetate fraction from Citrus aurantium leaf extract (EACA), associated with its phytochemical content, against the toxic impacts of acute exposure to carbon tetrachloride (CCl4) in the liver of adult rats.	ethyl acetate	68-81	C-C motif chemokine ligand 4	Rattus norvegicus	246-250
30843651-5	2019	Ethyl acetate fraction showed significant activity in the antiproliferative assay, with GI50 range of 3.9 to 27.2 mug mL-1 .	ethyl acetate	0-13	L1 cell adhesion molecule	Mus musculus	118-122
31169845-3	2019	In this study, the capacity of an ethyl acetate : hexane extract (CPE/hexane) and water extract (CPE/water) to modulate the cell cycle re-entry of quiescent (PC-3 and LNCaP) prostate cancer cells was tested in an in vitro culture system.	ethyl acetate	34-47	carboxypeptidase E	Homo sapiens	66-69
31281406-0	2019	Ethyl Acetate Extract of Asclepias curassavica Induced Apoptosis in Human Cancer Cells via Activating p38 and JNK MAPK Signaling Pathways.	ethyl acetate	0-13	mitogen-activated protein kinase 14	Homo sapiens	102-105
31281406-0	2019	Ethyl Acetate Extract of Asclepias curassavica Induced Apoptosis in Human Cancer Cells via Activating p38 and JNK MAPK Signaling Pathways.	ethyl acetate	0-13	mitogen-activated protein kinase 8	Homo sapiens	110-113
31353615-10	2019	Methanol extract, hexane, and ethyl acetate fractions and three polymethoxyflavonoids showed a significant inhibitory activity against expression of IL-1beta mRNA.	ethyl acetate	30-43	interleukin 1 alpha	Mus musculus	149-157
30794862-10	2019	RESULTS: We demonstrate that an ethyl acetate extract of Bassia longifolia and of Gmelina arborea have anti-inflammatory capacities, indicated by reduced proliferation, inhibition of IL-2 secretion and degranulation capacity of activated human T cells, when compared with adequate concentrations of synthetic positive drug controls.	ethyl acetate	32-45	interleukin 2	Homo sapiens	183-187
31511569-2	2019	In this study, gas chromatography coupled with mass spectrometry (GC-MS) was employed for the determination of signatures found in ER+/PR+ breast cancer cells derived from MCF-7 using different extraction solvents including: A, formic acid in water; B, ammonium hydroxide in water; C, ethyl acetate; D, methanol: water (1:1, v/v); and E, acetonitrile: water (1:1, v/v).	ethyl acetate	285-298	epiregulin	Homo sapiens	131-133
31522435-0	2019	Ethyl Acetate Fraction of Teucrium Polium Extract Abolishes Human Umbilical Vein Endothelial Cells (HUVEC) Tubulogenesis in Collagen Bed through Suppression of Cell Proliferation/VEGF Secretion.	ethyl acetate	0-13	vascular endothelial growth factor A	Homo sapiens	179-183
31522435-12	2019	The ethyl acetate fraction at 60 microg/ml inhibited VEGF secretion perfectly.	ethyl acetate	4-17	vascular endothelial growth factor A	Homo sapiens	53-57
30810845-6	2019	The final engineering strain CLy12a-ATF1-ACS2-CAB2 had a significant increase in ethyl acetate yield, reaching 610.26 (+- 14.28) mg/L, and the yield of higher alcohols was significantly decreased.	ethyl acetate	81-94	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	36-40
30810845-6	2019	The final engineering strain CLy12a-ATF1-ACS2-CAB2 had a significant increase in ethyl acetate yield, reaching 610.26 (+- 14.28) mg/L, and the yield of higher alcohols was significantly decreased.	ethyl acetate	81-94	acetate--CoA ligase ACS2	Saccharomyces cerevisiae S288C	41-45
30810845-6	2019	The final engineering strain CLy12a-ATF1-ACS2-CAB2 had a significant increase in ethyl acetate yield, reaching 610.26 (+- 14.28) mg/L, and the yield of higher alcohols was significantly decreased.	ethyl acetate	81-94	phosphopantothenate--cysteine ligase CAB2	Saccharomyces cerevisiae S288C	46-50
30917915-2	2019	Acetyl-L-carnitine (ALC) is an acetyl ester of L-carnitine that easily crosses the blood-brain barrier and was recently found to be decreased in patients with major depressive disorder.	ethyl acetate	31-43	allantoicase	Homo sapiens	20-23
30712820-6	2019	Seven compounds (tetrahydrocolumbamine, protopine, jatrorrhizine, glaucine, tetrahydropalmatine, palmatine, dehydrocorydaline) with high binding affinity to MAO-A were fished out from the ethyl acetate fraction extract of Corydalis Rhizome.	ethyl acetate	188-201	monoamine oxidase A	Homo sapiens	157-162
31342726-3	2019	The results showed that the ethyl acetate extraction and alcohol soluble fraction of the UW could significantly reduce the prostate index,reduce the serum DHT and EGF levels( P&lt;0.	ethyl acetate	28-41	epidermal growth factor	Mus musculus	163-166
31183001-0	2019	Ethyl Acetate Fraction of Lannea microcarpa Engl.	ethyl acetate	0-13	endo/exonuclease (5'-3'), endonuclease G-like	Mus musculus	44-48
30802715-11	2019	RESULTS: Ha-EtOAc inhibited the LPS-induced production of NO and decreased the release of TNF-alpha, IL-6 and IL-1beta in RAW264.7 cells in a dose-dependent manner.	ethyl acetate	12-17	tumor necrosis factor	Mus musculus	90-99
31457054-2	2019	Objectives: For increasing the ethyl acetate yield of industrial brewer"s yeast strain, all the ATF1 alleles were overexpressed through "self-cloning" integration strategy.	ethyl acetate	31-44	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	96-100
31457054-10	2019	Conclusions: These results verify that the ethyl acetate yield could be enhanced by the overexpressed of ATF1 in the polyploid industrial brewer"s yeast strains via "self-cloning" integration strategy.	ethyl acetate	43-56	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	105-109
30802715-11	2019	RESULTS: Ha-EtOAc inhibited the LPS-induced production of NO and decreased the release of TNF-alpha, IL-6 and IL-1beta in RAW264.7 cells in a dose-dependent manner.	ethyl acetate	12-17	interleukin 6	Mus musculus	101-105
30802715-11	2019	RESULTS: Ha-EtOAc inhibited the LPS-induced production of NO and decreased the release of TNF-alpha, IL-6 and IL-1beta in RAW264.7 cells in a dose-dependent manner.	ethyl acetate	12-17	interleukin 1 beta	Mus musculus	110-118
30668353-12	2019	RESULTS: The results showed that the ethyl acetate extract of A. asphodeloides (EAA) induced apoptotic and anti-proliferative activities through the STAT3 and MAPKs pathways.	ethyl acetate	37-50	signal transducer and activator of transcription 3	Homo sapiens	149-154
30467676-5	2019	Sakuranetin and (-)-naringenin, which were present in an ethyl acetate-soluble fraction of the bark extract, significantly inhibited NO induction and inducible nitric oxide synthase (iNOS) expression.	ethyl acetate	57-70	nitric oxide synthase 2	Homo sapiens	150-181
30467676-5	2019	Sakuranetin and (-)-naringenin, which were present in an ethyl acetate-soluble fraction of the bark extract, significantly inhibited NO induction and inducible nitric oxide synthase (iNOS) expression.	ethyl acetate	57-70	nitric oxide synthase 2	Homo sapiens	183-187
30727882-8	2019	Both extract and ethyl acetate fraction showed significant anti-inflammatory and antioxidant effects in LPS-treated RAW cells characterized by the inhibition of COX-2 and iNOS protein expression, as well as PGE2 and NO release.	ethyl acetate	17-30	cytochrome c oxidase II, mitochondrial	Mus musculus	161-166
29166772-4	2019	Ethyl acetate (EA) fractions of the three tested algae showed more potent antimicrobial activity against S. aureus (7-14.5 mm) and B. cereus (7-10.75 mm), MIC values ranged from 0.9375 to 7.5 mg mL-1 and MBC values &gt; 15 mg mL-1.	ethyl acetate	0-13	L1 cell adhesion molecule	Mus musculus	195-199
29166772-4	2019	Ethyl acetate (EA) fractions of the three tested algae showed more potent antimicrobial activity against S. aureus (7-14.5 mm) and B. cereus (7-10.75 mm), MIC values ranged from 0.9375 to 7.5 mg mL-1 and MBC values &gt; 15 mg mL-1.	ethyl acetate	0-13	L1 cell adhesion molecule	Mus musculus	226-230
29166772-4	2019	Ethyl acetate (EA) fractions of the three tested algae showed more potent antimicrobial activity against S. aureus (7-14.5 mm) and B. cereus (7-10.75 mm), MIC values ranged from 0.9375 to 7.5 mg mL-1 and MBC values &gt; 15 mg mL-1.	ethyl acetate	15-17	L1 cell adhesion molecule	Mus musculus	195-199
29166772-4	2019	Ethyl acetate (EA) fractions of the three tested algae showed more potent antimicrobial activity against S. aureus (7-14.5 mm) and B. cereus (7-10.75 mm), MIC values ranged from 0.9375 to 7.5 mg mL-1 and MBC values &gt; 15 mg mL-1.	ethyl acetate	15-17	L1 cell adhesion molecule	Mus musculus	226-230
29199468-7	2019	The EtOAc and BuOH extracts showed potent activity, with IC50 of 9.7 and 12.9 mug mL-1, respectively.	ethyl acetate	4-9	L1 cell adhesion molecule	Mus musculus	82-86
30890504-1	2019	OBJECTIVE: To investigate the effects of methanol-ethyl acetate partitioned fractions from Descurainia sophia (MEDS) on the proliferation and apoptosis of human non-small cell lung cancer H1975 cells.	ethyl acetate	50-63	immediate early response 3 interacting protein 1	Homo sapiens	111-115
30890504-12	2019	CONCLUSIONS: The methanol-ethyl acetate partitioned fractions from MEDS show potent anti-tumor activity both in vivo and in vitro, suggesting their value as promising therapeutic agents against lung cancer.	ethyl acetate	26-39	immediate early response 3 interacting protein 1	Homo sapiens	67-71
30668111-2	2019	In this study, a crude ethyl acetate extract of Machilus litseifolia was fractionated by solid-phase extraction using C18 cartridges to give a fraction enriched in alpha-glucosidase inhibitors.	ethyl acetate	23-36	sucrase-isomaltase	Homo sapiens	164-181
30572196-12	2019	These findings suggest that the ethyl acetate extract of A. lappa had strong anticancer potential and induced intrinsic apoptosis via loss of DeltaPsim and activation of caspase-3/7 This study can provide new insight to the discovery of new promising lead compound in chemopreventive and chemotherapeutic strategies.	ethyl acetate	32-45	caspase 3	Homo sapiens	170-179
30709346-4	2019	This study aimed to isolate and identify small-molecule STAT3 signaling inhibitors targeting CSCs from the ethyl acetate (EtOAc) extract of the roots of Polygonum cuspidatum and to evaluate their in vitro anti-cancer activities.	ethyl acetate	107-120	signal transducer and activator of transcription 3	Homo sapiens	56-61
30709346-4	2019	This study aimed to isolate and identify small-molecule STAT3 signaling inhibitors targeting CSCs from the ethyl acetate (EtOAc) extract of the roots of Polygonum cuspidatum and to evaluate their in vitro anti-cancer activities.	ethyl acetate	122-127	signal transducer and activator of transcription 3	Homo sapiens	56-61
30709346-13	2019	CONCLUSION: A novel juglone analogue 2-ethoxystypandrone was identified from the EtOAc extract of the roots of P. cuspidatum and was demonstrated to be a potent small-molecule STAT3 signaling inhibitor, which strongly blocked STAT3 activation, inhibited proliferation, and induced cell apoptosis of HCC cells and HCC CSCs.	ethyl acetate	81-86	signal transducer and activator of transcription 3	Homo sapiens	176-181
30709346-13	2019	CONCLUSION: A novel juglone analogue 2-ethoxystypandrone was identified from the EtOAc extract of the roots of P. cuspidatum and was demonstrated to be a potent small-molecule STAT3 signaling inhibitor, which strongly blocked STAT3 activation, inhibited proliferation, and induced cell apoptosis of HCC cells and HCC CSCs.	ethyl acetate	81-86	signal transducer and activator of transcription 3	Homo sapiens	226-231
30626086-2	2019	Ethyl acetate fraction of 80% ethanol extract of Phyllostachys nigra stem (PN3) containing polyphenols had a higher NQO1-ARE reporter gene activity as monitored by the activity of the NF-E2-related factor (Nrf2) antioxidant pathway in cells in comparison to extracts from other species and under other conditions.	ethyl acetate	0-13	sodium voltage-gated channel alpha subunit 10	Homo sapiens	75-78
30626086-2	2019	Ethyl acetate fraction of 80% ethanol extract of Phyllostachys nigra stem (PN3) containing polyphenols had a higher NQO1-ARE reporter gene activity as monitored by the activity of the NF-E2-related factor (Nrf2) antioxidant pathway in cells in comparison to extracts from other species and under other conditions.	ethyl acetate	0-13	NFE2 like bZIP transcription factor 2	Homo sapiens	206-210
30470454-5	2019	During the analysis of fluoridated phosphonate-spiked ethyl acetate extract of solid phase extraction (SPE, Bond Elut NEXUS) from fluoride-mediated regeneration of blank human plasma, LOD (on EIC at m/z 99 except for GAF (m/z 126)) were 25-140 pg/mL with sharp peak shapes.	ethyl acetate	54-67	fibroblast growth factor 9	Homo sapiens	217-220
30668375-0	2019	TRPA1 involvement in analgesia induced by Tabernaemontana catharinensis ethyl acetate fraction in mice.	ethyl acetate	72-85	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
30668375-3	2019	PURPOSE: Preclinical studies support the antinociceptive activity of Tabernaemontana catharinensis ethyl acetate fraction (Eta), which has constituents previously identified as TRPA1 antagonists (gallic acid).	ethyl acetate	99-112	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	177-182
30444319-7	2019	The IC50 values of crude extract and ethyl acetate extract were 0.580 and 0.828 mg mL-1 , equivalent to 60.99 % and 87.07 % of VC .	ethyl acetate	37-50	L1 cell adhesion molecule	Mus musculus	83-87
30727882-8	2019	Both extract and ethyl acetate fraction showed significant anti-inflammatory and antioxidant effects in LPS-treated RAW cells characterized by the inhibition of COX-2 and iNOS protein expression, as well as PGE2 and NO release.	ethyl acetate	17-30	nitric oxide synthase 2, inducible	Mus musculus	171-175
31702502-7	2019	Upon fractionation, chloroform fraction (Aa.Chm) exhibited the highest antiproliferative activity with IC50 6.55 +- 1.2 microg/ml followed by ethyl acetate (Aa.Et) fraction (IC50, 24.59 +- 0.85 microg/ml) and n-hexane (Aa.Hex) fraction (IC50 29.53 +- 1.5microg/ml).	ethyl acetate	142-155	CHM Rab escort protein	Homo sapiens	44-47
31550216-0	2019	Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer"s Disease.	ethyl acetate	0-22	monoamine oxidase B	Homo sapiens	100-119
30242672-11	2018	The production of ROS, caspase-3 activity and depolarized MMP were quite significant in MDA-MB-231 cell line treated with methanol and ethyl acetate extracts.	ethyl acetate	135-148	caspase 3	Homo sapiens	23-32
30633592-7	2019	Only the three constituents, including EtOH extractives, EtOAc soluble fraction and gallic acid (GA), exhibited inhibitory effects on the cell viability, migration and invasion by decreasing MMP2 and MMP9 expression (all P &lt; 0.05).	ethyl acetate	57-62	matrix metallopeptidase 2	Homo sapiens	191-195
30665368-8	2019	On screening the fungal ethyl acetate extracts for cytotoxicity against the HeLa cells, the Chaetomium nigricolor extract exhibited potent cytotoxic activity of 92.20% at 100 mug mL- 1 concentration.	ethyl acetate	24-37	L1 cell adhesion molecule	Mus musculus	179-184
30665368-11	2019	Further the screening of antioxidant potential of the ethyl acetate fungal extracts using DPPH scavenging assay showed that Chaetomium nigricolor extract exhibited potential activity with a significant EC50 value of 22 mug mL- 1.	ethyl acetate	54-67	L1 cell adhesion molecule	Mus musculus	223-228
31679283-8	2019	Among the fractions, the ethyl acetate fraction showed appreciable AChE-inhibitory (half-maximal inhibitory concentration [IC50] 0.81 +- 0.04 mg/mL) and DPPH scavenging (IC50 2.04 +- 0.77 mug/mL) activities; therefore it was subjected to flash chromatography, which separated 9 subfractions.	ethyl acetate	25-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
30728952-9	2018	Conclusion: These results indicate that the ethyl acetate extracts obtained from the inner bark of T. chrysantha and T. rosea have an important antioxidant effect mediated by Nrf2 activation, and could be used as a new source of natural antioxidants.	ethyl acetate	44-57	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
29972254-0	2018	An ethyl acetate fraction of Artemisia capillaris (ACE-63) induced apoptosis and anti-angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma.	ethyl acetate	3-16	AKT serine/threonine kinase 1	Homo sapiens	122-125
30717553-4	2018	The results showed that ethyl acetate fraction had relatively high concentration of TFC (0.61+-0.10) g g-1DW, TPC (0.52+-0.09) g g-1DW, and TSC (0.21+-0.03) g g-1DW, with high scavenging capacity of DPPH (3.1+-0.38) mmol L-1 g-1DW and FRAP (2.56+-0.35) mmol L-1 g-1DW.	ethyl acetate	24-37	TSC complex subunit 1	Homo sapiens	129-143
30717553-4	2018	The results showed that ethyl acetate fraction had relatively high concentration of TFC (0.61+-0.10) g g-1DW, TPC (0.52+-0.09) g g-1DW, and TSC (0.21+-0.03) g g-1DW, with high scavenging capacity of DPPH (3.1+-0.38) mmol L-1 g-1DW and FRAP (2.56+-0.35) mmol L-1 g-1DW.	ethyl acetate	24-37	mechanistic target of rapamycin kinase	Homo sapiens	235-239
30118566-5	2018	Two homozygous knock-out mutants of Arabidopsis, tbl10-1 and tbl10-2, were isolated and shown to exhibit reduced levels of wall-bound acetyl esters, equivalent of ~50% of the wild-type level in pectin-enriched fractions derived from leaves.	ethyl acetate	134-147	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	49-54
30118566-5	2018	Two homozygous knock-out mutants of Arabidopsis, tbl10-1 and tbl10-2, were isolated and shown to exhibit reduced levels of wall-bound acetyl esters, equivalent of ~50% of the wild-type level in pectin-enriched fractions derived from leaves.	ethyl acetate	134-147	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	61-66
29981847-4	2018	Secondly, the anti-diabetes effects of the ethyl acetate extracts of the aerial parts/fruit (EAP/EAF) of P. alkekengi were evaluated in high-fat diet-fed and streptozotocin-induced diabetic rats (seven groups, n = 7) daily at doses of 300 and 600 mg/kg for 28 days.	ethyl acetate	43-56	ribosomal protein L22	Homo sapiens	93-96
30297610-3	2018	The ethyl acetate fraction of the initial ethanol extract decreased the activity of tyrosinase, a key enzyme in the synthetic pathway of melanin.	ethyl acetate	4-17	tyrosinase	Mus musculus	84-94
29998488-9	2018	The ethyl acetate extract of the peel induced quinone reductase 1 activity in Hepa1c1c7 cells, indicating that C. maxima exhibited cancer chemopreventive properties.	ethyl acetate	4-17	NAD(P)H dehydrogenase, quinone 1	Mus musculus	46-65
29727488-6	2018	Further, at the end of shock situation the concentrations of ethyl acetate were 1.2- and 1.3-fold higher than the wild type for P HSP104 and P UBI4, respectively.	ethyl acetate	61-74	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	130-136
30154260-5	2018	Unexpectedly, a higher level of acetate esters (including ethyl acetate) was produced when eat1K179fs was present together with ATF1 in the same strain, suggesting that the Eat1 and Atf1 enzymes are intertwined.	ethyl acetate	58-71	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	128-132
30154260-5	2018	Unexpectedly, a higher level of acetate esters (including ethyl acetate) was produced when eat1K179fs was present together with ATF1 in the same strain, suggesting that the Eat1 and Atf1 enzymes are intertwined.	ethyl acetate	58-71	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	182-186
30154260-6	2018	On the other hand, introduction of snf8E148* lowered ethyl acetate levels also in the presence of ATF1, and it affected other aroma compounds, growth, and fermentation as well.	ethyl acetate	53-66	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	98-102
30154260-8	2018	Our work has identified EAT1 and SNF8 as new genetic elements determining ethyl acetate production diversity in yeast strains.IMPORTANCE Basic research with laboratory strains of the yeast Saccharomyces cerevisiae has identified the structural genes of most metabolic enzymes, as well as genes encoding major regulators of metabolism.	ethyl acetate	74-87	ESCRT-II subunit protein SNF8	Saccharomyces cerevisiae S288C	33-37
29730133-8	2018	Kf-EtOAc induces apoptosis by the intrinsic pathway; this mechanism of cell death was confirmed after observing that the extract produces phosphatidylserine translocation, overproduction of reactive oxygen species, release of Cytochrome C at mitochondrial level, and activation of caspase-3 and -9.	ethyl acetate	3-8	cytochrome c, somatic	Homo sapiens	226-238
29730133-8	2018	Kf-EtOAc induces apoptosis by the intrinsic pathway; this mechanism of cell death was confirmed after observing that the extract produces phosphatidylserine translocation, overproduction of reactive oxygen species, release of Cytochrome C at mitochondrial level, and activation of caspase-3 and -9.	ethyl acetate	3-8	caspase 3	Homo sapiens	281-297
30510740-2	2018	This study investigated the effect of the ethyl acetate fraction from O. japonicus extract (OJE) on the growth inhibition of OVCAR-3 human ovarian cancer cells demonstrated to inhibit cell growth and arrest the cell cycle in OVCAR-3 cells by blocking the sub-G1 phase and decreasing cyclin E1/CDK2 expression.	ethyl acetate	42-55	cyclin E1	Homo sapiens	283-292
30510740-2	2018	This study investigated the effect of the ethyl acetate fraction from O. japonicus extract (OJE) on the growth inhibition of OVCAR-3 human ovarian cancer cells demonstrated to inhibit cell growth and arrest the cell cycle in OVCAR-3 cells by blocking the sub-G1 phase and decreasing cyclin E1/CDK2 expression.	ethyl acetate	42-55	cyclin dependent kinase 2	Homo sapiens	293-297
30067035-1	2018	The ethyl acetate extract of the aerial parts of Chresta martii showed significant in vitro NF-kappaB inhibition.	ethyl acetate	4-17	nuclear factor kappa B subunit 1	Homo sapiens	92-101
29968042-2	2018	A CAF/DAP cocrystal (1:1 M ratio) was successfully prepared by slow evaporation from both acetone and ethyl acetate.	ethyl acetate	102-115	lysine acetyltransferase 2B	Homo sapiens	2-9
29727488-6	2018	Further, at the end of shock situation the concentrations of ethyl acetate were 1.2- and 1.3-fold higher than the wild type for P HSP104 and P UBI4, respectively.	ethyl acetate	61-74	ubiquitin	Saccharomyces cerevisiae S288C	143-147
29725352-0	2018	Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Inflammatory Effects by Regulating miR-155 Expression and JNK Signaling Pathway.	ethyl acetate	0-13	microRNA 155	Mus musculus	117-124
30146750-2	2018	METHOD: Cyclo-oxygenase (COX)-2:COX-1 selectivity assay was carried out by plating isolated peripheral blood mononuclear cells in culture medium with specific SBL fractions: crude extract (J), ethyl-acetate (JE) and aqueous (JA); secondary compounds from JE (JE5, JE6, JE7 and JE8); purified (P9) and semi-purified (P8) compounds from JE5 at 5-200 mug/mL for 1 hour.	ethyl acetate	193-206	cox2	Sorghum bicolor	8-31
30146750-2	2018	METHOD: Cyclo-oxygenase (COX)-2:COX-1 selectivity assay was carried out by plating isolated peripheral blood mononuclear cells in culture medium with specific SBL fractions: crude extract (J), ethyl-acetate (JE) and aqueous (JA); secondary compounds from JE (JE5, JE6, JE7 and JE8); purified (P9) and semi-purified (P8) compounds from JE5 at 5-200 mug/mL for 1 hour.	ethyl acetate	193-206	cox1	Sorghum bicolor	32-37
29447981-3	2018	Mechanistic analysis also showed that ethyl acetate extracts of aerial parts and fruit of PA (PAG-EA and PAF-EA) enhanced glucose transporter 4 expression and function as well as enhanced insulin sensitivity by inhibiting the expression of cytochrome P450-2E1 (CYP2E1) mRNA and protein.	ethyl acetate	38-51	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	261-267
29444384-7	2018	CONCLUSIONS: Decreased expression of ACS1 and ACS2 together with increased ALD3 expression contributes to the higher acetic acid and lower ethyl acetate levels generated by K1-V1116 fermenting under hyperosmotic stress.	ethyl acetate	139-152	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	37-41
29444384-7	2018	CONCLUSIONS: Decreased expression of ACS1 and ACS2 together with increased ALD3 expression contributes to the higher acetic acid and lower ethyl acetate levels generated by K1-V1116 fermenting under hyperosmotic stress.	ethyl acetate	139-152	acetate--CoA ligase ACS2	Saccharomyces cerevisiae S288C	46-50
29444384-7	2018	CONCLUSIONS: Decreased expression of ACS1 and ACS2 together with increased ALD3 expression contributes to the higher acetic acid and lower ethyl acetate levels generated by K1-V1116 fermenting under hyperosmotic stress.	ethyl acetate	139-152	aldehyde dehydrogenase (NAD(+)) ALD3	Saccharomyces cerevisiae S288C	75-79
29861455-8	2018	Furthermore, the ethyl acetate fraction of M. indica had a considerably higher (p &lt; 0.05) inhibitory effect on alpha-glucosidase (IC50 = 25.11 +- 0.01 mug mL-1), and alpha-amylase (IC50 = 24.04 +- 0.12 mug mL-1) activities than the S. mombin fraction.	ethyl acetate	17-30	L1 cell adhesion molecule	Mus musculus	158-162
29861455-8	2018	Furthermore, the ethyl acetate fraction of M. indica had a considerably higher (p &lt; 0.05) inhibitory effect on alpha-glucosidase (IC50 = 25.11 +- 0.01 mug mL-1), and alpha-amylase (IC50 = 24.04 +- 0.12 mug mL-1) activities than the S. mombin fraction.	ethyl acetate	17-30	L1 cell adhesion molecule	Mus musculus	209-213
29772805-0	2018	Ethyl Acetate Fraction from Persimmon (Diospyros kaki) Ameliorates Cerebral Neuronal Loss and Cognitive Deficit via the JNK/Akt Pathway in TMT-Induced Mice.	ethyl acetate	0-13	mitogen-activated protein kinase 8	Mus musculus	120-123
29772805-0	2018	Ethyl Acetate Fraction from Persimmon (Diospyros kaki) Ameliorates Cerebral Neuronal Loss and Cognitive Deficit via the JNK/Akt Pathway in TMT-Induced Mice.	ethyl acetate	0-13	thymoma viral proto-oncogene 1	Mus musculus	124-127
29174446-0	2018	Protective effect of ethyl acetate fraction of Drynaria quercifolia against CCl4 induced rat liver fibrosis via Nrf2/ARE and NFkappaB signalling pathway.	ethyl acetate	21-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	112-116
29393456-0	2018	Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway.	ethyl acetate	0-13	signal transducer and activator of transcription 3	Homo sapiens	117-122
29393456-0	2018	Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway.	ethyl acetate	0-13	AKT serine/threonine kinase 1	Homo sapiens	123-126
29518973-4	2018	The compounds isolated from the ethyl acetate layer were used at different concentrations to treat HT-1080 human fibrosarcoma cells and to evaluate their effects on matrix metalloprotease 2 (MMP-2) and 9 (MMP-9) expression.	ethyl acetate	32-45	matrix metallopeptidase 2	Homo sapiens	165-189
29518973-4	2018	The compounds isolated from the ethyl acetate layer were used at different concentrations to treat HT-1080 human fibrosarcoma cells and to evaluate their effects on matrix metalloprotease 2 (MMP-2) and 9 (MMP-9) expression.	ethyl acetate	32-45	matrix metallopeptidase 2	Homo sapiens	191-203
29518973-4	2018	The compounds isolated from the ethyl acetate layer were used at different concentrations to treat HT-1080 human fibrosarcoma cells and to evaluate their effects on matrix metalloprotease 2 (MMP-2) and 9 (MMP-9) expression.	ethyl acetate	32-45	matrix metallopeptidase 9	Homo sapiens	205-210
29786737-1	2018	This study aimed to investigate the ameliorating effect of an ethyl acetate fraction from the fruit Actinidia arguta (EFAA) on amyloid beta (Abeta)-induced neurotoxicity and cognitive deficits in ICR mice.	ethyl acetate	62-75	amyloid beta precursor protein	Homo sapiens	141-146
29568291-9	2018	Cytotoxicity investigation with a cancer cell line revealed that the ethyl acetate extract of I. cordata was highly cytotoxic against A-431 cancer cell line, increasing the inhibitory ratio to 91.1 and 95.6% after 24 and 48 h exposure, respectively, for a concentration of 500 mug mL-1.	ethyl acetate	69-82	L1 cell adhesion molecule	Mus musculus	281-285
29314788-2	2018	In this study, for ethyl acetate yield regulation, we finely modulated the expression of ATF1 through precise and seamless insertion of serially truncated PGK1 promoter from the 3" end by 100bp steps in the Chinese liquor yeast, CLy12a.	ethyl acetate	19-32	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	89-93
29314788-2	2018	In this study, for ethyl acetate yield regulation, we finely modulated the expression of ATF1 through precise and seamless insertion of serially truncated PGK1 promoter from the 3" end by 100bp steps in the Chinese liquor yeast, CLy12a.	ethyl acetate	19-32	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	155-159
29725352-0	2018	Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Inflammatory Effects by Regulating miR-155 Expression and JNK Signaling Pathway.	ethyl acetate	0-13	mitogen-activated protein kinase 8	Mus musculus	140-143
29725352-4	2018	Ethyl acetate fraction from the aqueous extract of the couplet at equal weight ratio (EA11) showed the strongest inhibition of the nitrite accumulation in supernatant of RAW264.7 cells stimulated with lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma).	ethyl acetate	0-13	interferon gamma	Mus musculus	226-242
29725352-4	2018	Ethyl acetate fraction from the aqueous extract of the couplet at equal weight ratio (EA11) showed the strongest inhibition of the nitrite accumulation in supernatant of RAW264.7 cells stimulated with lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma).	ethyl acetate	0-13	interferon gamma	Mus musculus	244-253
29310316-6	2018	Among the FDA derivatives examined, FOMe-Ac, the acetyl ester of fluorescein O-methyl ether, was found to be a potential reporter for GSH-dependent GSTP1 activity as well as for carboxylesterase activity.	ethyl acetate	49-61	glutathione S-transferase pi 1	Homo sapiens	148-153
29504313-5	2018	The ethyl acetate fraction (ZEF) consisted of higher content of phenolics, flavonoids, procyanidins, and catechin monomers (including epigallocatechin gallate (EGCG), epicatechin gallate (ECG), and gallocatechin gallate (GCG)) than n-butanol fraction (ZBF) and water fraction (ZWF).	ethyl acetate	4-17	glucagon	Mus musculus	198-225
29434241-3	2018	In the present study we identified the presence of a mTOR inhibitor in an active fraction of the ethyl acetate extract of Streptomyces sp OA293.	ethyl acetate	97-110	mechanistic target of rapamycin kinase	Homo sapiens	53-57
29618430-7	2018	The ethyl acetate fraction significantly altered LDH levels and reduced IL-6 transcript expression on MCF7 cell line but not in HepG2 cell line which could be specific anti-inflammatory drug in breast cancer cell line.	ethyl acetate	4-17	interleukin 6	Homo sapiens	72-76
29248832-0	2018	Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation.	ethyl acetate	16-29	insulin receptor substrate 1	Rattus norvegicus	138-142
29248832-0	2018	Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation.	ethyl acetate	16-29	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
28402540-13	2017	We also demonstrated that hepassocin increased SOD1 expression through an extracellular signal-regulated kinase 1/2 nuclear factor erythroid-2-related factor 2 pathway, decreasing ethyl acetate-induced ROS production and improving cell viability.	ethyl acetate	180-193	fibrinogen like 1	Homo sapiens	26-36
29433394-0	2018	Ethyl Acetate Fraction from Dendropanax morbifera Leaves Increases T Cell Growth by Upregulating NF-AT-Mediated IL-2 Secretion.	ethyl acetate	0-13	interleukin 2	Mus musculus	112-116
29433394-5	2018	The ethyl acetate (W-EA) fraction showed a more significant effect than the other fractions on the growth of EL-4 T cells, splenocytes, and isolated murine CD4[Formula: see text] T cells.	ethyl acetate	4-17	CD4 antigen	Mus musculus	156-159
29366410-7	2018	The progress of the reaction was monitored by TLC (EtOAc: petroleum ether 1:3).	ethyl acetate	51-56	lipocalin 1	Homo sapiens	46-49
29251256-9	2017	Petroleum ether and ethyl acetate extracts greatly reduced interleukin-4 expression and the interleukin-4/interferon gamma ratio.	ethyl acetate	20-33	interleukin 4	Mus musculus	59-72
29251256-9	2017	Petroleum ether and ethyl acetate extracts greatly reduced interleukin-4 expression and the interleukin-4/interferon gamma ratio.	ethyl acetate	20-33	interleukin 4	Mus musculus	92-105
29218012-0	2017	Anti-tumor Effect of Rhaponticum uniflorum Ethyl Acetate Extract by Regulation of Peroxiredoxin1 and Epithelial-to-Mesenchymal Transition in Oral Cancer.	ethyl acetate	43-56	peroxiredoxin 1	Homo sapiens	82-96
28322066-6	2017	Ethyl acetate extracts of R. crataegifolius showed strong antioxidant activities and significant protective effect against acute hepatotoxicity induced by CCl4.	ethyl acetate	0-13	chemokine (C-C motif) ligand 4	Mus musculus	155-159
28993612-5	2017	Here we show that ESKIMO1/XOAT1/TBL29, a xylan-specific O-acetyltransferase, is necessary for generation of the even pattern of acetyl esters on xylan in Arabidopsis.	ethyl acetate	128-141	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	18-25
28993612-5	2017	Here we show that ESKIMO1/XOAT1/TBL29, a xylan-specific O-acetyltransferase, is necessary for generation of the even pattern of acetyl esters on xylan in Arabidopsis.	ethyl acetate	128-141	trichome birefringence-like protein (DUF828)	Arabidopsis thaliana	32-37
28917599-7	2017	In nano-LC, the CSP was stressed under the use of strong organic solvents such as ethyl acetate, acetone and methyl t-butyl ether (MTBE).	ethyl acetate	82-95	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	16-19
28488331-9	2017	The aqueous and ethyl acetate leaf extracts were also potent growth inhibitors of C. jeikeium and S. epidermidis (MICs &lt; 1000 mug mL-1 ).	ethyl acetate	16-29	L1 cell adhesion molecule	Mus musculus	133-137
28876919-2	2017	In vitro, the ethyl acetate extract of C. maritimum Makino (ECMM) significantly inhibited beta-hexosaminidase release and decreased intracellular Ca2+ levels in RBL-2H3 cells.	ethyl acetate	14-27	O-GlcNAcase	Rattus norvegicus	90-109
28870197-14	2017	The antiproliferative activity against Hep-G2 hepatoma cancer cell line was demonstrated by n-hexane, ethylacetate and methanol-distilled water (IC50 8.65-8.95 mug/ml) extracts.	ethyl acetate	102-114	DNL-type zinc finger	Homo sapiens	39-42
28552757-4	2017	In this study, we established a highly sensitive, selective, quantitative, and simple method for detection of selenol and selenide, using a reaction with monochlorobimane (MCB), followed by ethyl acetate extraction of the product syn-(methyl,methyl)bimane.	ethyl acetate	190-203	synemin	Homo sapiens	230-233
28778164-26	2017	CONCLUSION: These results are an evidence of the renal protective role of S.cordat ethyl acetate fraction against CCl4 induced nephrotoxicity in rats which may be due to its antioxidant compounds.	ethyl acetate	83-96	C-C motif chemokine ligand 4	Rattus norvegicus	114-118
28568378-5	2017	Moreover, the 70% ethyl acetate in n-hexane chromatographic fraction showed significant activity displaying IC50 values of 53.0, 52.4 and 49.1 mug/mL against the cancer cell lines A549, MCF7 and PC3, respectively.	ethyl acetate	18-31	chromobox 8	Homo sapiens	195-198
28568378-6	2017	Encouragingly, an IC50 of 510.0 mug/mL against the human normal prostate cell line PNT2 indicated very low toxicity and hence favourable selectivity indices for the 70% ethyl acetate in n-hexane fraction in the range of 9.6-10.4 towards cell lines A549, MCF7 and PC3.	ethyl acetate	169-182	chromobox 8	Homo sapiens	263-266
28284637-4	2017	Drying the disks overnight at 25 C followed by elution with ethyl acetate resulted in extraction recoveries between 75.9% and 120% and limits of quantification of 0.290ngL-1 for estrone, 1.37ngL-1 for 17beta-estradiol, 0.724ngL-1 for 17alpha-ethynyl estradiol and 0.119ngL-1 for diclofenac.	ethyl acetate	60-73	leucine rich repeat containing 4C	Homo sapiens	168-173
29149031-2	2017	This study was conducted both in vitro and in vivo on the ethyl acetate extract (PD1) of farmed red macroalgae in order to explore its anti-inflammatory properties.	ethyl acetate	58-71	programmed cell death 1	Mus musculus	81-84
28728382-17	2017	Porcine myocyte MyHC I and MyHC IIx mRNA expression were increased, and MyHC IIa and MyHC IIb mRNA expression were down-regulated by 5 mug/mL TCMF ethyl acetate extraction (p&lt;0.05).	ethyl acetate	147-160	myosin-2	Sus scrofa	72-80
28728382-17	2017	Porcine myocyte MyHC I and MyHC IIx mRNA expression were increased, and MyHC IIa and MyHC IIb mRNA expression were down-regulated by 5 mug/mL TCMF ethyl acetate extraction (p&lt;0.05).	ethyl acetate	147-160	myosin-4	Sus scrofa	85-93
28728382-18	2017	MyHC I and MyHC IIa mRNA expression in porcine myocytes were increased, and the MyHC IIb mRNA expression was decreased by 1 mug/mL TCMF ethyl acetate extraction (p&lt;0.05).	ethyl acetate	136-149	myosin-4	Sus scrofa	80-88
28844483-4	2017	The results of serum alanine/aspartate aminotransferase (ALT/AST) showed the remarkable hepatotoxicity induced by ethyl acetate fraction of Airpotato yam (EF) (450mg/kg) and diosbulbin B (DB) (300mg/kg) in mice.	ethyl acetate	114-127	glutamic pyruvic transaminase, soluble	Mus musculus	57-60
28844483-4	2017	The results of serum alanine/aspartate aminotransferase (ALT/AST) showed the remarkable hepatotoxicity induced by ethyl acetate fraction of Airpotato yam (EF) (450mg/kg) and diosbulbin B (DB) (300mg/kg) in mice.	ethyl acetate	114-127	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	61-64
29142422-9	2017	The ethyl acetate fractions of all the examined species showed a marked hepatoprotective efficacy accounting for 54.78%, 55.46%, and 56.42% reduction in serum level of alanine transaminase and 56.82%, 54.16%, and 57.06% suppression in serum level of aspartate transaminase, respectively, at 100 mug/mL comparable to CCl4-treated cells.	ethyl acetate	4-17	C-C motif chemokine ligand 4	Homo sapiens	316-320
29142435-11	2017	Cytotoxicity of ethyl acetate fraction was the highest among other fractions against HCT-116, HeLa, and MCF-7cancer cell lines with IC50 values 16.55 +- 1.28, 12.38 +- 1.36, and 8.03 +- 1.9 mug/ml, respectively, by MTT assay and 15.57 +- 0.70, 13.19 +- 0.49, and 10.34 +- 0.9 mug/ml, respectively, by SRB assay.	ethyl acetate	16-29	chaperonin containing TCP1 subunit 4	Homo sapiens	301-304
28402540-13	2017	We also demonstrated that hepassocin increased SOD1 expression through an extracellular signal-regulated kinase 1/2 nuclear factor erythroid-2-related factor 2 pathway, decreasing ethyl acetate-induced ROS production and improving cell viability.	ethyl acetate	180-193	superoxide dismutase 1	Homo sapiens	47-51
28515715-2	2017	The minimum inhibitory concentration (MIC) of the ethyl acetate (EtOAc) extract from P. cucumerina against P. aeruginosa PAO1 was 1.25 mg mL-1.	ethyl acetate	50-63	L1 cell adhesion molecule	Mus musculus	138-142
28756924-2	2017	METHODS: Hepatoprotectivity of ethyl acetate extract of Achaetomium sp., was evaluated by CCl4 induced toxicity in HepG2 cells and subsequently analysed for cell viability using MTT assay.	ethyl acetate	31-44	C-C motif chemokine ligand 4	Homo sapiens	90-94
28756924-7	2017	It was observed to be dose dependent, when CCl4 exposed HepG2 cells were treated with different concentrations of ethyl acetate extract.	ethyl acetate	114-127	C-C motif chemokine ligand 4	Homo sapiens	43-47
28515715-2	2017	The minimum inhibitory concentration (MIC) of the ethyl acetate (EtOAc) extract from P. cucumerina against P. aeruginosa PAO1 was 1.25 mg mL-1.	ethyl acetate	65-70	L1 cell adhesion molecule	Mus musculus	138-142
28401470-2	2017	H460 cells treated with the ethyl acetate extract of strain MCCB 248 and stained with Hoechst 33342 showed clear signs of apoptosis, including shrinkage of the cell nucleus, DNA fragmentation and chromatin condensation.	ethyl acetate	28-41	methylcrotonyl-CoA carboxylase subunit 2	Homo sapiens	60-64
28529735-2	2017	Therefore, the present study investigated the effects of hot water, ethanol and ethyl acetate extracts of rosehip on xanthine oxidase (XO) activity in vitro.	ethyl acetate	80-93	xanthine dehydrogenase	Mus musculus	117-133
28562598-11	2017	Attraction to ethyl acetate was Orco dependent and also required the odorant specificity subunit Or42b.	ethyl acetate	14-27	Odorant receptor co-receptor	Drosophila melanogaster	32-36
28562598-12	2017	The addition of the airborne Orco antagonist OX1w to the experimental chamber abolished larval chemotaxis towards ethyl acetate.	ethyl acetate	114-127	Odorant receptor co-receptor	Drosophila melanogaster	29-33
28529735-2	2017	Therefore, the present study investigated the effects of hot water, ethanol and ethyl acetate extracts of rosehip on xanthine oxidase (XO) activity in vitro.	ethyl acetate	80-93	xanthine dehydrogenase	Mus musculus	135-137
28562598-11	2017	Attraction to ethyl acetate was Orco dependent and also required the odorant specificity subunit Or42b.	ethyl acetate	14-27	Odorant receptor 42b	Drosophila melanogaster	97-102
28529735-5	2017	Rosehip extracts of hot water, ethanol and ethyl acetate inhibited XO activity [half maximal inhibitory concentration (IC50) values: 259.6+-50.6, 242.5+-46.2 and 1,462.8+-544.2 microg/ml, respectively].	ethyl acetate	43-56	xanthine dehydrogenase	Mus musculus	67-69
28529456-0	2017	Ethyl acetate fraction of Huogu formula inhibits adipogenic differentiation of bone marrow stromal cells via the BMP and Wnt signaling pathways.	ethyl acetate	0-13	Wnt family member 3A	Rattus norvegicus	121-124
28390404-5	2017	On the basis of potent antioxidant ability; the ethyl acetate fraction (JDEE) was selected to evaluate the in vivo antioxidant activity against CCl4 induced oxidative stress in rat.	ethyl acetate	48-61	C-C motif chemokine ligand 4	Rattus norvegicus	144-148
28302396-12	2017	The SAS co-precipitation process using a mixture of ethyl acetate/dimethyl sulfoxide demonstrates that this strategy can be successful for controlling rifampicin delivery.	ethyl acetate	52-65	tetraspanin 31	Homo sapiens	4-7
30263566-4	2017	The ethyl acetate fraction of PGP exhibited the anti-allergic activity by suppressing beta-hexosaminidase release, a marker of degranulation, from antigen/immunoglobulin E (IgE)-stimulated RBL-2H3 cells.	ethyl acetate	4-17	phosphoglycolate phosphatase	Rattus norvegicus	30-33
30263566-4	2017	The ethyl acetate fraction of PGP exhibited the anti-allergic activity by suppressing beta-hexosaminidase release, a marker of degranulation, from antigen/immunoglobulin E (IgE)-stimulated RBL-2H3 cells.	ethyl acetate	4-17	O-GlcNAcase	Rattus norvegicus	86-105
28383530-8	2017	The petroleum ether extract, the ethyl acetate extract and decarine showed anti-inflammatory activities through inhibiting TNF-alpha and IL-1beta production in lipopolysaccharide-stimulated THP-1 cells without cell toxicity too.	ethyl acetate	33-46	tumor necrosis factor	Homo sapiens	123-132
28383530-8	2017	The petroleum ether extract, the ethyl acetate extract and decarine showed anti-inflammatory activities through inhibiting TNF-alpha and IL-1beta production in lipopolysaccharide-stimulated THP-1 cells without cell toxicity too.	ethyl acetate	33-46	interleukin 1 beta	Homo sapiens	137-145
28367982-3	2017	Immunohistochemical results showed that the EtOAc extract significantly decreased the number of Iba-1-positive cells in the hippocampal region of LPS-treated mouse brains.	ethyl acetate	44-49	induction of brown adipocytes 1	Mus musculus	96-101
28529456-4	2017	Our results showed that ethyl acetate extract of HG (HGE) significantly decreased the adipocyte differentiation as determined by oil red staining, while slightly increased the ALP activity.	ethyl acetate	24-37	PDZ and LIM domain 3	Rattus norvegicus	176-179
28401088-4	2017	In brief, RSL powder was fractionated into n-hexane, chloroform, ethyl acetate, n-butanol, and water-soluble fractions.	ethyl acetate	65-78	regulator of sex limited protein-Slp	Mus musculus	10-13
28260011-0	2017	Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity.	ethyl acetate	0-13	prostaglandin-endoperoxide synthase 2	Mus musculus	144-149
28260011-0	2017	Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity.	ethyl acetate	0-13	nitric oxide synthase 2, inducible	Mus musculus	150-154
27878299-2	2017	First, it was found in previous experiments that an ethyl acetate extract of Capparis spinosa L. (CSE) exhibited antioxidant activity.	ethyl acetate	52-65	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	98-101
28001065-2	2017	In this study, ethyl acetate parts of aqueous extracts from P. vulgaris L. (EtOAc-APV) were found to demonstrate potent acetylcholinesterase (AChE) inhibition in vitro.	ethyl acetate	15-28	acetylcholinesterase	Rattus norvegicus	120-140
28001065-2	2017	In this study, ethyl acetate parts of aqueous extracts from P. vulgaris L. (EtOAc-APV) were found to demonstrate potent acetylcholinesterase (AChE) inhibition in vitro.	ethyl acetate	15-28	acetylcholinesterase	Rattus norvegicus	142-146
28001352-4	2017	Compared with GO membrane, these MOF@GO membranes combine the unique properties of MOF and GO and thus have significant enhancements of pervaporation (PV) permeation flux and separation factor simultaneously for ethyl acetate/water mixtures (98/2, w/w) through the PV process, which are also superior to the reported other kinds of membranes.	ethyl acetate	212-225	lysine acetyltransferase 8	Homo sapiens	33-36
28001352-4	2017	Compared with GO membrane, these MOF@GO membranes combine the unique properties of MOF and GO and thus have significant enhancements of pervaporation (PV) permeation flux and separation factor simultaneously for ethyl acetate/water mixtures (98/2, w/w) through the PV process, which are also superior to the reported other kinds of membranes.	ethyl acetate	212-225	lysine acetyltransferase 8	Homo sapiens	83-86
28386546-0	2017	Ethyl Acetate Extracts of Semen Impatientis Inhibit Proliferation and Induce Apoptosis of Human Prostate Cancer Cell Lines through AKT/ERK Pathways.	ethyl acetate	0-13	AKT serine/threonine kinase 1	Homo sapiens	131-134
28386546-0	2017	Ethyl Acetate Extracts of Semen Impatientis Inhibit Proliferation and Induce Apoptosis of Human Prostate Cancer Cell Lines through AKT/ERK Pathways.	ethyl acetate	0-13	mitogen-activated protein kinase 1	Homo sapiens	135-138
28386546-11	2017	After being treated with different concentrations of ethyl acetate extracts, the percentage of G0/G1 phase increased significantly, cyclin D1 and cyclin E expression decreased, apoptosis rate was significantly higher, and the ability of migration of PC-3 and RV1 was inhibited significantly.	ethyl acetate	53-66	cyclin D1	Homo sapiens	132-141
27228199-8	2016	In vivo experiment demonstrated that both HM-1 and ethyl acetate extracts could inhibit Cyp3a2 in rats.	ethyl acetate	51-64	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	88-94
27802902-3	2016	Alcoholic extract along with petroleum ether, dichloromethane and ethyl acetate fractions were subjected to SRB assay in HCT-116, MDA-MB-231 and A549 cell lines.	ethyl acetate	66-79	chaperonin containing TCP1 subunit 4	Homo sapiens	108-111
26916801-10	2016	Besides, the ethyl acetate extract inhibited phospholipase A2 activity (IC50 value: 2.97 mg/mL) and reduced the paw oedema in mice (from 0.38 +- 0.01 to 0.24 +- 0.01 cm), 4 h post-carrageenan challenge.	ethyl acetate	13-26	phospholipase A2, group IB, pancreas	Mus musculus	45-61
27647013-15	2016	Both EtOAc and MeOH extract-administered groups displayed significant remission in the levels of TNF-alpha, VEGF and IL-6.	ethyl acetate	5-10	tumor necrosis factor	Rattus norvegicus	97-106
27647013-15	2016	Both EtOAc and MeOH extract-administered groups displayed significant remission in the levels of TNF-alpha, VEGF and IL-6.	ethyl acetate	5-10	vascular endothelial growth factor A	Rattus norvegicus	108-112
27647013-15	2016	Both EtOAc and MeOH extract-administered groups displayed significant remission in the levels of TNF-alpha, VEGF and IL-6.	ethyl acetate	5-10	interleukin 6	Rattus norvegicus	117-121
27681250-6	2016	RESULTS: The ethyl acetate fraction had the greatest inhibitory effect on alpha-glucosidase, followed by n-butanol, sediment and residual aqua fractions (with the IC50 values of 0.26 mg/mL, 2.94 mg/mL, 3.02 mg/mL, and 5.24 mg/mL, respectively), mainly due to the high content of polyphenols.	ethyl acetate	13-26	sucrase-isomaltase	Homo sapiens	74-91
27681250-7	2016	Among the eight subfractions (QEF1-8) isolated from the ethyl acetate fraction, QEF8 fraction showed the highest alpha-glucosidase inhibitory potential in a competitive inhibitory manner (the K i value of 77.10 mug/mL).	ethyl acetate	56-69	sucrase-isomaltase	Homo sapiens	113-130
28925130-4	2016	The results showed that ethyl acetate portion of unripe Forsythiae Fructus had a better anti-inflammatory activity against acute lung injury, and could suppress the release of inflammatory factors of IL-6, TNF-alpha, IL-1beta, significantly reduce contents of creatine, beta-OH-butyrate, succinate, lysine, valine, isoleucine and glutamine, and elevate the content of GPC in serum.	ethyl acetate	24-37	interleukin 6	Rattus norvegicus	200-204
27262685-10	2016	Overall, the combination of solvents that produced the best results for solvent system I consisted of denatured ethanol, HPLC grade water, and ACS grade ethyl acetate.	ethyl acetate	153-166	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	143-146
27344573-8	2016	Meanwhile, the contents of acetyl-CoA and ethyl acetate were enhanced by alpha5-FAS1DeltaOPI1.	ethyl acetate	42-55	transcriptional regulator OPI1	Saccharomyces cerevisiae S288C	80-93
28925130-4	2016	The results showed that ethyl acetate portion of unripe Forsythiae Fructus had a better anti-inflammatory activity against acute lung injury, and could suppress the release of inflammatory factors of IL-6, TNF-alpha, IL-1beta, significantly reduce contents of creatine, beta-OH-butyrate, succinate, lysine, valine, isoleucine and glutamine, and elevate the content of GPC in serum.	ethyl acetate	24-37	tumor necrosis factor	Rattus norvegicus	206-215
28925130-4	2016	The results showed that ethyl acetate portion of unripe Forsythiae Fructus had a better anti-inflammatory activity against acute lung injury, and could suppress the release of inflammatory factors of IL-6, TNF-alpha, IL-1beta, significantly reduce contents of creatine, beta-OH-butyrate, succinate, lysine, valine, isoleucine and glutamine, and elevate the content of GPC in serum.	ethyl acetate	24-37	interleukin 1 beta	Rattus norvegicus	217-225
28925130-4	2016	The results showed that ethyl acetate portion of unripe Forsythiae Fructus had a better anti-inflammatory activity against acute lung injury, and could suppress the release of inflammatory factors of IL-6, TNF-alpha, IL-1beta, significantly reduce contents of creatine, beta-OH-butyrate, succinate, lysine, valine, isoleucine and glutamine, and elevate the content of GPC in serum.	ethyl acetate	24-37	glycophorin C	Rattus norvegicus	368-371
27246748-5	2016	The protective effect of the ethyl acetate fraction from A. cardamomum (EAAC) against CCl4-induced cytotoxicity was determined by a cell viability assay using HepG2 hepatocarcinoma cells.	ethyl acetate	29-42	C-C motif chemokine ligand 4	Rattus norvegicus	86-90
28487900-7	2016	MATERIALS AND METHODS: In this study, the anti-inflammatory effects of the ethyl acetate fraction of the methanol extract of FF (FFE) were assessed by measuring NO and PGE2 production by and intracellular ROS and protein levels of iNOS and COX-2 in RAW 264.7 cells.	ethyl acetate	75-88	nitric oxide synthase 2, inducible	Mus musculus	231-235
28487900-7	2016	MATERIALS AND METHODS: In this study, the anti-inflammatory effects of the ethyl acetate fraction of the methanol extract of FF (FFE) were assessed by measuring NO and PGE2 production by and intracellular ROS and protein levels of iNOS and COX-2 in RAW 264.7 cells.	ethyl acetate	75-88	cytochrome c oxidase II, mitochondrial	Mus musculus	240-245
27372351-8	2016	Furthermore, at molecular level, it was demonstrated that the HEPa/EtOAc treatment was able to improve these physiological parameters, through the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) per si, as well as the enhancement of antioxidant mechanism by an increase in PPARgamma/Cu(2+), Zn(2+)-superoxide dismutase (CuZn-SOD) axis expression in liver and adipose tissue.	ethyl acetate	67-72	peroxisome proliferator activated receptor gamma	Mus musculus	211-220
27372351-8	2016	Furthermore, at molecular level, it was demonstrated that the HEPa/EtOAc treatment was able to improve these physiological parameters, through the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) per si, as well as the enhancement of antioxidant mechanism by an increase in PPARgamma/Cu(2+), Zn(2+)-superoxide dismutase (CuZn-SOD) axis expression in liver and adipose tissue.	ethyl acetate	67-72	peroxisome proliferator activated receptor gamma	Mus musculus	300-309
27372351-8	2016	Furthermore, at molecular level, it was demonstrated that the HEPa/EtOAc treatment was able to improve these physiological parameters, through the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) per si, as well as the enhancement of antioxidant mechanism by an increase in PPARgamma/Cu(2+), Zn(2+)-superoxide dismutase (CuZn-SOD) axis expression in liver and adipose tissue.	ethyl acetate	67-72	superoxide dismutase 1, soluble	Mus musculus	347-355
27761064-7	2016	RESULTS: GS extracts showed differential effect on CYP activities in the following order of inhibitory potency: ethyl acetate &gt; Chloroform &gt; methanol &gt; n-hexane &gt; aqueous &gt; DGA.	ethyl acetate	112-125	peptidylprolyl isomerase G	Homo sapiens	51-54
27761064-9	2016	The ethyl acetate and chloroform extract exhibited moderate inhibition towards CYP1A2 and 3A4.	ethyl acetate	4-17	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	79-85
27761064-11	2016	CONCLUSION: The results of our study revealed that phytoconstituents contained in GS, particularly in ethyl acetate and chloroform extracts, were able to inhibit CYP1A2, 3A4 and 2C9.	ethyl acetate	102-115	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	162-168
27029351-3	2016	RESULTS: Among these fractions, the ethyl acetate fraction had the highest total polyphenol content (100.5 +- 1.6 mg GAE/g dried extract) and alpha-glucosidase inhibitory activity (126.8 +- 30.6 mug/ml).	ethyl acetate	36-49	sucrase isomaltase (alpha-glucosidase)	Mus musculus	142-159
26806571-5	2016	The translocation of nuclear factor-kappa B (NF-kappaB) and the involvements of Akt and mitogen-activated protein (MAP) kinases in ethyl acetate fraction of PAF (PAF-EA)-mediated anti-inflammatory effect were measured using Western blotting.	ethyl acetate	131-144	thymoma viral proto-oncogene 1	Mus musculus	80-83
26806571-5	2016	The translocation of nuclear factor-kappa B (NF-kappaB) and the involvements of Akt and mitogen-activated protein (MAP) kinases in ethyl acetate fraction of PAF (PAF-EA)-mediated anti-inflammatory effect were measured using Western blotting.	ethyl acetate	131-144	patchy fur	Mus musculus	157-160
26806571-5	2016	The translocation of nuclear factor-kappa B (NF-kappaB) and the involvements of Akt and mitogen-activated protein (MAP) kinases in ethyl acetate fraction of PAF (PAF-EA)-mediated anti-inflammatory effect were measured using Western blotting.	ethyl acetate	131-144	patchy fur	Mus musculus	162-168
27279697-9	2016	SUMMARY: Flavonoid-enriched ethyl acetate (EA) fraction from A. esculentus protected against ultraviolet-B (UV-B)-induced oxidative DNA damageEA fraction prevented UV-B-induced cytotoxicity, depletion of endogenous enzymatic antioxidants, and intracellular reactive oxygen species productionEA fraction could reduce oxidative stress through the Nrf2-ARE PathwayEA fraction was found to be nongenotoxic and prevented apoptotic changes.	ethyl acetate	28-41	NFE2 like bZIP transcription factor 2	Homo sapiens	345-349
27279697-9	2016	SUMMARY: Flavonoid-enriched ethyl acetate (EA) fraction from A. esculentus protected against ultraviolet-B (UV-B)-induced oxidative DNA damageEA fraction prevented UV-B-induced cytotoxicity, depletion of endogenous enzymatic antioxidants, and intracellular reactive oxygen species productionEA fraction could reduce oxidative stress through the Nrf2-ARE PathwayEA fraction was found to be nongenotoxic and prevented apoptotic changes.	ethyl acetate	43-45	NFE2 like bZIP transcription factor 2	Homo sapiens	345-349
27910773-5	2016	Ethyl acetate extract significantly enhanced adipogenic differentiation and glucose uptake in 3T3-L1 adipocytes via the expression of sterol regulatory element-binding protein, peroxisome proliferator-activated receptor gamma, and phos-phatidylinositol 3-kinase/Akt.	ethyl acetate	0-13	thymoma viral proto-oncogene 1	Mus musculus	262-265
26980998-8	2016	In addition, the crude methanol extract and EtOAc strongly inhibited alpha-glucosidase activity and suppressed the secretion of pro-inflammatory mediator and nitrite oxide from LPS-stimulated RAW 264.7 cells.	ethyl acetate	44-49	sucrase isomaltase (alpha-glucosidase)	Mus musculus	69-86
26777153-5	2016	RESULTS: After an ethyl-acetate group was introduced to the His(18) of hIAPP by diethylpyrocarbonate (DEPC) modification, the pH dependent hIAPP fibrillation went to the opposite order and the number of intra-molecular hydrogen bonds decreased, while the possibility of His(18) participating in the formation of alpha-helical structures increased.	ethyl acetate	18-31	islet amyloid polypeptide	Homo sapiens	71-76
26945232-2	2016	In this study, the protective effects of ethyl acetate extracts were evaluated against CCl4-induced liver injuries in rat.	ethyl acetate	41-54	C-C motif chemokine ligand 4	Rattus norvegicus	87-91
26893742-10	2016	The IC50 values obtained for the PC3 cell line were 37.97+-3.87, 51.57+-3.87 and 70.33+-2.36 for the CH2Cl2 fraction, the EtOAc fraction and the methanol extract, respectively.	ethyl acetate	122-127	chromobox 8	Homo sapiens	33-36
27165249-7	2016	Among multiple extracts and essential oils of the plant, only the ethyl acetate extract could significantly decrease cell viability in PC3 cells, in a concentration dependent manner.	ethyl acetate	66-79	chromobox 8	Homo sapiens	135-138
27165249-8	2016	Ethyl acetate extract of N. cataria treated cells showed a sub-G1 peak in PC3 cells in a concentration dependent manner that indicates the involvement of an apoptotic process in ethyl acetate extract-induced cell death.	ethyl acetate	0-13	chromobox 8	Homo sapiens	74-77
27165249-8	2016	Ethyl acetate extract of N. cataria treated cells showed a sub-G1 peak in PC3 cells in a concentration dependent manner that indicates the involvement of an apoptotic process in ethyl acetate extract-induced cell death.	ethyl acetate	178-191	chromobox 8	Homo sapiens	74-77
27165249-9	2016	Western blotting analysis showed that in PC3 cells treated with ethyl acetate (48 h) caspase 3 and PARP were cleaved to active forms.	ethyl acetate	64-77	chromobox 8	Homo sapiens	41-44
27829862-6	2016	Neuroprotective capacity against beta-amyloid (Abeta) peptide induced toxicity in PC12 cells of EtOAc fraction showed a significant protective activity at lower concentration (25 and 50 microM).	ethyl acetate	96-101	amyloid beta precursor protein	Rattus norvegicus	33-53
26254612-0	2016	Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.	ethyl acetate	0-12	caspase 8	Homo sapiens	90-97
28228817-3	2016	The cells were treated with varying concentrations (0.001- 0.25 mg/mL) of this fraction for 24, 48 and 72 h. Apoptosis induced in MCF-7 cells following treatment with ethyl acetate fraction was measured using Annexin V/PI, flowcytometry and western blotting analysis.	ethyl acetate	167-180	annexin A5	Homo sapiens	209-218
29023018-12	2016	On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway.	ethyl acetate	253-266	AKT serine/threonine kinase 1	Homo sapiens	83-86
29023018-12	2016	On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway.	ethyl acetate	253-266	nuclear factor kappa B subunit 1	Homo sapiens	135-157
29023018-12	2016	On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway.	ethyl acetate	253-266	nuclear factor kappa B subunit 1	Homo sapiens	159-168
29023018-12	2016	On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway.	ethyl acetate	253-266	nuclear factor kappa B subunit 1	Homo sapiens	349-358
29023018-12	2016	On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway.	ethyl acetate	253-266	AKT serine/threonine kinase 1	Homo sapiens	414-417
29023018-13	2016	CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-kappaB) squamous cell carcinoma of the tongue.	ethyl acetate	12-25	AKT serine/threonine kinase 1	Homo sapiens	137-140
29023018-13	2016	CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-kappaB) squamous cell carcinoma of the tongue.	ethyl acetate	12-25	nuclear factor kappa B subunit 1	Homo sapiens	145-167
29023018-13	2016	CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-kappaB) squamous cell carcinoma of the tongue.	ethyl acetate	12-25	nuclear factor kappa B subunit 1	Homo sapiens	169-178
26406978-9	2015	The SPF obtained (~25) depended on the concentration of the ethyl acetate fraction and pomegranate seed oil in the nanoemulsion.	ethyl acetate	60-73	SEC14 like lipid binding 2	Homo sapiens	4-7
27141670-4	2015	The petroleum ether (PE) fraction and ethyl acetate (EtOAc) fraction could significant cause intestinal edema in mice, increase the water content of duodenum, colon and stool, inhibited the mRNA expression of AQP1 and increased the mRNA level of AQP3 in colon, and the petroleum ether (PE) fraction was more poisonous.	ethyl acetate	38-51	aquaporin 1	Mus musculus	209-213
27141670-4	2015	The petroleum ether (PE) fraction and ethyl acetate (EtOAc) fraction could significant cause intestinal edema in mice, increase the water content of duodenum, colon and stool, inhibited the mRNA expression of AQP1 and increased the mRNA level of AQP3 in colon, and the petroleum ether (PE) fraction was more poisonous.	ethyl acetate	38-51	aquaporin 3	Mus musculus	246-250
27141670-4	2015	The petroleum ether (PE) fraction and ethyl acetate (EtOAc) fraction could significant cause intestinal edema in mice, increase the water content of duodenum, colon and stool, inhibited the mRNA expression of AQP1 and increased the mRNA level of AQP3 in colon, and the petroleum ether (PE) fraction was more poisonous.	ethyl acetate	53-58	aquaporin 1	Mus musculus	209-213
25645824-7	2015	Ethylene glycol, ethyl acetate, and dimethyl sulphoxide inhibited PPAR-gamma transactivation in a dose-dependent manner.	ethyl acetate	17-30	peroxisome proliferator activated receptor gamma	Homo sapiens	66-76
27356389-9	2015	RESULTS: Compared with the model group ,the proteinuria of the rats in ethyl acetate group obviously reduced at the 6th, 7th, 8th week, the content of TNF-alpha in serum and the expression of TGF-beta1, and NF-kappaB p65 in renal tissues significantly reduced, but the content of TP and ALB in serum were increased obviously.	ethyl acetate	71-84	tumor necrosis factor	Rattus norvegicus	151-160
27356389-9	2015	RESULTS: Compared with the model group ,the proteinuria of the rats in ethyl acetate group obviously reduced at the 6th, 7th, 8th week, the content of TNF-alpha in serum and the expression of TGF-beta1, and NF-kappaB p65 in renal tissues significantly reduced, but the content of TP and ALB in serum were increased obviously.	ethyl acetate	71-84	transforming growth factor, beta 1	Rattus norvegicus	192-201
27356389-9	2015	RESULTS: Compared with the model group ,the proteinuria of the rats in ethyl acetate group obviously reduced at the 6th, 7th, 8th week, the content of TNF-alpha in serum and the expression of TGF-beta1, and NF-kappaB p65 in renal tissues significantly reduced, but the content of TP and ALB in serum were increased obviously.	ethyl acetate	71-84	synaptotagmin 1	Rattus norvegicus	217-220
27356389-9	2015	RESULTS: Compared with the model group ,the proteinuria of the rats in ethyl acetate group obviously reduced at the 6th, 7th, 8th week, the content of TNF-alpha in serum and the expression of TGF-beta1, and NF-kappaB p65 in renal tissues significantly reduced, but the content of TP and ALB in serum were increased obviously.	ethyl acetate	71-84	albumin	Rattus norvegicus	287-290
26081168-6	2015	The ethyl acetate fraction inhibited nitric oxide and prostaglandin E2 production in RAW 264.7 cells and the production of thymus- and activation-regulated chemokine (TARC) in HaCaT cells more than did the other fractions.	ethyl acetate	4-17	chemokine (C-C motif) ligand 17	Mus musculus	123-165
26983216-2	2015	Compared with model groups, ethyl acetate extract group showed a decreasing trend in ascites; the amount of urine of showed a significant increase (P &lt; 0.05); the level of urinary sodium, potassium, chloride ion (P &lt; 0.05, P &lt; 0.01), pH (P &lt; 0.05), and the content of PRL1, AII, ALD in serum all showed a significant decrease (P &lt; 0.01).	ethyl acetate	28-41	protein tyrosine phosphatase 4A1	Rattus norvegicus	280-284
26983216-5	2015	The results showed that ethyl acetate extract is the active part of Kansui Radix stir-baked with vinegar on the function of expelling water retention with drastic purgative on the cancerous ascites model rats, alleviating the water-electrolyte disorder and body fluid acid-base imbalance, regulating the renin angiotensin aldosterone system.	ethyl acetate	24-37	renin	Rattus norvegicus	304-309
26081168-6	2015	The ethyl acetate fraction inhibited nitric oxide and prostaglandin E2 production in RAW 264.7 cells and the production of thymus- and activation-regulated chemokine (TARC) in HaCaT cells more than did the other fractions.	ethyl acetate	4-17	chemokine (C-C motif) ligand 17	Mus musculus	167-171
26197325-5	2015	Among the extracts and phases tested, only the ethyl acetate and butanolic partitions significantly inhibited human thrombin activity and the coagulation of plasma in the presence of this enzyme.	ethyl acetate	47-60	coagulation factor II, thrombin	Homo sapiens	116-124
26283543-16	2015	Further study indicated that pretreatment of PC12 cells with ethyl acetate and n-butanol fractions, prior to hypoxia exposure, significantly increased the survival of cells and the activities of SOD, CAT, GSH-Px and T-AOC, as well as reduced the level of LDH and MDA.	ethyl acetate	61-74	catalase	Rattus norvegicus	200-203
26124811-4	2015	RESULTS: The EtOH/EtOAc 2:1 extract exhibited a potent inhibition of the hG-IIA with an IC50 values of 8 microg/ml.	ethyl acetate	18-23	glucosidase II alpha subunit	Homo sapiens	73-79
25651187-6	2015	Ethyl acetate extract decreased intracellular reactive oxygen species and significantly suppressed COX-2, IL-8, and prostaglandin E2 production and neutrophil chemotaxis by suppressing the translocation of the p65 subunit.	ethyl acetate	0-13	prostaglandin-endoperoxide synthase 2	Homo sapiens	99-104
25651187-6	2015	Ethyl acetate extract decreased intracellular reactive oxygen species and significantly suppressed COX-2, IL-8, and prostaglandin E2 production and neutrophil chemotaxis by suppressing the translocation of the p65 subunit.	ethyl acetate	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
25651187-6	2015	Ethyl acetate extract decreased intracellular reactive oxygen species and significantly suppressed COX-2, IL-8, and prostaglandin E2 production and neutrophil chemotaxis by suppressing the translocation of the p65 subunit.	ethyl acetate	0-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	210-213
25721496-2	2015	Chemical analysis of an EtOAc extract of a M. furfur strain obtained from diseased human skin and grown on l-tryptophan agar revealed several known AhR active tryptophan metabolites along with a previously unidentified compound, pityriazepin.	ethyl acetate	24-29	aryl hydrocarbon receptor	Homo sapiens	148-151
25792018-1	2015	ETHNOPHARMACOLOGICAL RELEVANCE: The radix of Acorus calamus L. (AC) is widely used in diabetes therapies in traditional folk medicine from America and Indonesia, and we have previously reported that the ethyl acetate fraction of AC (ACE) acts as an antidiabetic through insulin sensitizing, insulin releasing and alpha-glucosidase inhibitory activities.	ethyl acetate	203-216	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	233-236
25666426-6	2015	RESULTS: Our results showed that the ethyl acetate fraction and HPE significantly alleviated liver injury as indicated by the decreased levels of serum ALT and AST and reduce the pathological tissue damage induced by CCl4.	ethyl acetate	37-50	glutamic pyruvic transaminase, soluble	Mus musculus	152-155
25666426-6	2015	RESULTS: Our results showed that the ethyl acetate fraction and HPE significantly alleviated liver injury as indicated by the decreased levels of serum ALT and AST and reduce the pathological tissue damage induced by CCl4.	ethyl acetate	37-50	transmembrane protease, serine 11d	Mus musculus	160-163
25666426-6	2015	RESULTS: Our results showed that the ethyl acetate fraction and HPE significantly alleviated liver injury as indicated by the decreased levels of serum ALT and AST and reduce the pathological tissue damage induced by CCl4.	ethyl acetate	37-50	chemokine (C-C motif) ligand 4	Mus musculus	217-221
25716870-7	2015	In order to identify the active components in CWE, we re-extracted CWE using several solvents, and found that the ethyl acetate fraction was the most effective in suppressing the expression of VCAM-1 and ICAM-1.	ethyl acetate	114-127	vascular cell adhesion molecule 1	Mus musculus	193-199
25716870-7	2015	In order to identify the active components in CWE, we re-extracted CWE using several solvents, and found that the ethyl acetate fraction was the most effective in suppressing the expression of VCAM-1 and ICAM-1.	ethyl acetate	114-127	intercellular adhesion molecule 1	Mus musculus	204-210
25716870-8	2015	Four major acetophenones were purified from the ethyl acetate fraction, and two components, p-hydroxyacetophenone and cynandione A, potently inhibited the expression of ICAM-1 and VCAM-1 in the stimulated HASMCs.	ethyl acetate	48-61	intercellular adhesion molecule 1	Mus musculus	169-175
25716870-8	2015	Four major acetophenones were purified from the ethyl acetate fraction, and two components, p-hydroxyacetophenone and cynandione A, potently inhibited the expression of ICAM-1 and VCAM-1 in the stimulated HASMCs.	ethyl acetate	48-61	vascular cell adhesion molecule 1	Mus musculus	180-186
25829764-3	2015	MATERIALS AND METHODS: Major compounds from the ethyl acetate fraction were isolated by column chromatography and their anticancer potentials against U87 cells were evaluated.	ethyl acetate	48-61	small nucleolar RNA, C/D box 87	Homo sapiens	150-153
25759957-3	2015	The in vitro study showed that the active fraction (CF6) obtained from the ethyl acetate extract (EMD) and its component 2",6",4-trihydroxy-4"-methoxybenzophenone increased the SR-BI expression by 95% and 60%, respectively.	ethyl acetate	75-88	scavenger receptor class B, member 1	Rattus norvegicus	177-182
25356658-0	2015	Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells.	ethyl acetate	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
25356658-0	2015	Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells.	ethyl acetate	0-13	BCL2 apoptosis regulator	Homo sapiens	135-140
25557029-8	2015	RESULTS: The results demonstrated that n-hexane, ethyl acetate and n-butanol extracts from the flower of E.gardneri were able to significantly activate PPARgamma and PPARbeta respectively, and the activity of ethyl acetate extract was much better.	ethyl acetate	49-62	peroxisome proliferator activated receptor delta	Homo sapiens	166-174
25756649-10	2015	Compared with control groups, mice serum containing ethyl acetate fraction had a inhibition effect on SMMC-7721 cell, SGC-7901 cell, MCF-7 cell, HeLa cell, A549 cell, HT-29, and MDA-MB-231, respectively, but mice serum containing other four fractions had no different with that of control group.	ethyl acetate	52-65	sarcoglycan beta	Homo sapiens	118-121
25756649-11	2015	The inhibition capabilities of mice serum containing ethyl acetate fraction on the seven cell lines in descending order is SGC-7901 &gt; SMMC-7721 &gt; MCF-7 &gt; HT-29 &gt; A549 &gt; HeLa &gt; MDA-MB-231.	ethyl acetate	53-66	serglycin	Mus musculus	123-126
24417211-5	2015	Only ethyl acetate extracts of the culture filtrates of these isolates exhibited the PL inhibition.	ethyl acetate	5-18	pancreatic lipase	Homo sapiens	85-87
25596758-0	2015	Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.	ethyl acetate	117-131	prostaglandin-endoperoxide synthase 2	Homo sapiens	142-147
25596758-1	2015	We report herein the synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl, sulfamoyl acetamides and ethyl acetates that selectively inhibit cyclooxygenase-2 (COX-2) isoform.	ethyl acetate	135-149	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-191
25596758-1	2015	We report herein the synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl, sulfamoyl acetamides and ethyl acetates that selectively inhibit cyclooxygenase-2 (COX-2) isoform.	ethyl acetate	135-149	prostaglandin-endoperoxide synthase 2	Homo sapiens	193-198
24417211-6	2015	#57 TBBLAM ethyl acetate extract of culture filtrate exhibited potential PL inhibition with an IC50 of 3.69 microg/ml which was comparable to the positive control, i.e. Orlistat exhibiting IC50 value of 2.73 microg/ml.	ethyl acetate	11-24	pancreatic lipase	Homo sapiens	73-75
25694702-3	2015	Of different fractions, the ethyl acetate fraction (QEF) had the highest total polyphenols and catechins contents, demonstrated the strongest DPPH radical scavenging activity and exhibited the greatest inhibitory effect on porcine pancreatic alpha-amylase activity in vitro.	ethyl acetate	28-41	amylase alpha 2A	Homo sapiens	231-255
26870685-0	2016	Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines.	ethyl acetate	77-90	La ribonucleoprotein 6, translational regulator	Homo sapiens	104-108
26870685-11	2016	Therefore, the effect of total extract and n-hexane and ethyl acetate fractions of N. sativa on cell viability and apoptosis in the ACHN cell line is greater than in the GP-293 cell line.	ethyl acetate	56-69	La ribonucleoprotein 6, translational regulator	Homo sapiens	132-136
25148961-4	2015	All data were comprehended below the taster"s threshold detection limit: ethyl acetate 39.48 ng mL(-1) (RSD mean value 4.2%), isoamyl acetate 3.88 ng mL(-1) (RSD mean value 3.4%), ethyl hexanoate 0.61 ng mL(-1) (RSD mean value 3.1%) and 2,3-butanedione 0.10 ng mL(-1) (RSD mean value 2.9%).	ethyl acetate	73-86	L1 cell adhesion molecule	Mus musculus	96-102
25853968-3	2015	OBJECTIVE: The objective of this study was to evaluate the protective effect of standardized hydro-methanol extract of C. pluricaulis (CPE) and its fractions, namely ethyl acetate (EAE), butanol (BE), and aqueous (AE), against 3-nitropropionic acid (3-NP) induced neurotoxicity in rats.	ethyl acetate	181-184	carboxypeptidase E	Rattus norvegicus	135-138
25380641-1	2015	The present study was aimed to investigate in vitro alpha-glucosidase inhibition, antioxidant, anticancer, and antimycobacterial activities of the ethyl acetate extract of A. tamilnadensis leaves.	ethyl acetate	147-160	sucrase-isomaltase	Homo sapiens	52-69
25380641-8	2015	The current study suggests that the ethyl acetate extract of A. tamilnadensis is a potential source of natural alpha-glucosidase inhibitor and antioxidant for protection as well as prevention of life-threatening diseases like cancer.	ethyl acetate	36-49	sucrase-isomaltase	Homo sapiens	111-128
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	ethyl acetate	29-42	sucrase-isomaltase	Homo sapiens	140-157
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	ethyl acetate	44-49	sucrase-isomaltase	Homo sapiens	140-157
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	ethyl acetate	98-111	sucrase-isomaltase	Homo sapiens	140-157
25841374-6	2015	It was found that the fruits ethyl acetate (EtOAc), the fruits butanolic (n-BuOH) and the flowers ethyl acetate (EtOAc) fractions inhibited alpha-glucosidase in a non competitive manner with IC50 values of 0.11+-0.09, 0.28+-0.04 and 0.221+-0.01mg/ml, respectively.	ethyl acetate	113-118	sucrase-isomaltase	Homo sapiens	140-157
25467201-4	2014	Treatment with 100 mug/ml ethyl acetate fraction (REF), which was isolated from water extract of the seeds, significantly inhibited LPS-stimulated production of nitric oxide (P &lt; 0.05), interleukin-6 (P &lt; 0.001), and tumor necrosis factor (TNF)-alpha (P &lt; 0.001) in RAW264.7 cells.	ethyl acetate	26-39	interleukin 6	Mus musculus	189-202
25467201-4	2014	Treatment with 100 mug/ml ethyl acetate fraction (REF), which was isolated from water extract of the seeds, significantly inhibited LPS-stimulated production of nitric oxide (P &lt; 0.05), interleukin-6 (P &lt; 0.001), and tumor necrosis factor (TNF)-alpha (P &lt; 0.001) in RAW264.7 cells.	ethyl acetate	26-39	tumor necrosis factor	Mus musculus	223-256
25853968-9	2015	CPE (200 mg/kg), EAE (30 mg/kg), and BE (50 mg/kg) significantly (p &lt; 0.001) attenuated 3-NP induced reduction in locomotor activity, grip strength, memory, body weight, and oxidative defense in comparison with 3-NP-treated animals on 10 and 15 d. CONCLUSION: The present study suggested that CPE has a protective action against 3-NP-induced neurotoxicity and can be further explored for its efficacy against Huntington"s disease.	ethyl acetate	17-20	carboxypeptidase E	Rattus norvegicus	296-299
23990384-8	2014	Animals pre-treated with CHE, Hex, EA, Aq, vitexin and quinic acid exhibited decreases in leukocytes, exudate concentrations, MPO and ADA activities and NOx levels (p &lt; 0.05).	ethyl acetate	35-37	myeloperoxidase	Mus musculus	126-129
25333742-0	2014	Ethyl acetate extract from Jiedu Xiaozheng Yin inhibits the proliferation of human hepatocellular carcinoma cells by suppressing polycomb gene product Bmi1 and Wnt/beta-catenin signaling.	ethyl acetate	0-13	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	151-155
25333742-0	2014	Ethyl acetate extract from Jiedu Xiaozheng Yin inhibits the proliferation of human hepatocellular carcinoma cells by suppressing polycomb gene product Bmi1 and Wnt/beta-catenin signaling.	ethyl acetate	0-13	catenin beta 1	Homo sapiens	164-176
24617288-0	2014	The ethyl acetate fraction of Sargassum muticum attenuates ultraviolet B radiation-induced apoptotic cell death via regulation of MAPK- and caspase-dependent signaling pathways in human HaCaT keratinocytes.	ethyl acetate	4-17	mitogen-activated protein kinase 3	Homo sapiens	130-134
24617288-0	2014	The ethyl acetate fraction of Sargassum muticum attenuates ultraviolet B radiation-induced apoptotic cell death via regulation of MAPK- and caspase-dependent signaling pathways in human HaCaT keratinocytes.	ethyl acetate	4-17	caspase 9	Homo sapiens	140-147
22336595-5	2014	Acute exposure of the HepG2 cells to the ethyl acetate extract produced a significant regulation of caspase-3 with the peak expression at 8 hours of treatment (P&lt; .05).	ethyl acetate	41-54	caspase 3	Homo sapiens	100-109
25026715-4	2014	Furthermore, the five compounds isolated from the ethyl acetate extract of Cassia occidentalis roots were found to suppress LPS-induced IL-1beta, TNF-alpha and NO production in a concentration-dependent manner in these cells at 1C50 values ranging from 22.5 to 97.4 microM.	ethyl acetate	50-63	interleukin 1 beta	Mus musculus	136-144
25026715-4	2014	Furthermore, the five compounds isolated from the ethyl acetate extract of Cassia occidentalis roots were found to suppress LPS-induced IL-1beta, TNF-alpha and NO production in a concentration-dependent manner in these cells at 1C50 values ranging from 22.5 to 97.4 microM.	ethyl acetate	50-63	tumor necrosis factor	Mus musculus	146-155
25310977-2	2014	Several of these fruity metabolites, including isoamyl acetate and ethyl acetate, are produced by a dedicated enzyme, the alcohol acetyl transferase Atf1.	ethyl acetate	67-80	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	149-153
24857157-6	2014	The ethyl acetate fraction of the ginger hot water extract remarkably induced AHR-mediated transcriptional activity, and the major active compound was found to be 6-shogaol.	ethyl acetate	4-17	aryl hydrocarbon receptor	Homo sapiens	78-81
24686392-1	2014	HPW@Hollow S-1, a novel solid catalyst which can be reused in the synthesis of ethyl acetate, was successfully prepared by the ship-in-bottle approach.	ethyl acetate	79-92	proteasome 26S subunit, non-ATPase 1	Homo sapiens	11-14
23990384-8	2014	Animals pre-treated with CHE, Hex, EA, Aq, vitexin and quinic acid exhibited decreases in leukocytes, exudate concentrations, MPO and ADA activities and NOx levels (p &lt; 0.05).	ethyl acetate	35-37	adenosine deaminase	Mus musculus	134-137
24572641-1	2014	In this study, a compound with antioxidant and anti-HIV activities designated as HEB was first isolated from the edible mushroom Pholiota adiposa by extraction with ethanol and ethyl acetate.	ethyl acetate	177-190	transcription factor 12	Homo sapiens	81-84
24450585-0	2014	Experimental and modeling study of the thermal decomposition of C3-C5 ethyl esters behind reflected shock waves.	ethyl acetate	70-82	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	64-69
24528133-7	2014	Both ethanol and ethyl acetate extracts provided antiadhesion of H. pylori to AGS cells and down-regulation on the CagA, IL-8, COX-2, and iNOS expressions.	ethyl acetate	17-30	S100 calcium binding protein A8	Homo sapiens	115-119
24528133-7	2014	Both ethanol and ethyl acetate extracts provided antiadhesion of H. pylori to AGS cells and down-regulation on the CagA, IL-8, COX-2, and iNOS expressions.	ethyl acetate	17-30	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
24528133-7	2014	Both ethanol and ethyl acetate extracts provided antiadhesion of H. pylori to AGS cells and down-regulation on the CagA, IL-8, COX-2, and iNOS expressions.	ethyl acetate	17-30	prostaglandin-endoperoxide synthase 2	Homo sapiens	127-132
24528133-7	2014	Both ethanol and ethyl acetate extracts provided antiadhesion of H. pylori to AGS cells and down-regulation on the CagA, IL-8, COX-2, and iNOS expressions.	ethyl acetate	17-30	nitric oxide synthase 2	Homo sapiens	138-142
25102692-5	2014	RESULTS: Among the fractions tested, ethylacetate fraction exhibited the anti-AChE activity (25.83% +/- 0.23%) properly and excellent 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical and superoxide anion scavenging capacity (87.50% +/- 0.83% and 60.22% +/- 0.43%, respectively).	ethyl acetate	37-49	acetylcholinesterase	Mus musculus	78-82
24406787-6	2014	The ethyl acetate extract was also found to reduce the inflammation pain of acetic acid-induced writhing model in a dose-dependent manner and cause reduction of the ALI in mice through the inhibition of the release of PGE2 and the LPS-induced COX-2 expression in the lung.	ethyl acetate	4-17	prostaglandin-endoperoxide synthase 2	Mus musculus	243-248
24406787-7	2014	CONCLUSION: Our study demonstrates that the ethyl acetate extract of the plant can help to reduce inflammations by inhibiting the expression of COX-2.	ethyl acetate	44-57	prostaglandin-endoperoxide synthase 2	Mus musculus	144-149
24157579-2	2014	In this study, the effect of ethyl acetate extract of Nan Mu Xiang (NMX) on cardiac fibrosis was assessed in vitro by cultured adult rat cardiac fibroblasts with angiotensin II (AngII) stimulation, and in vivo by rats with abdominal aorta constriction (AAC).	ethyl acetate	29-42	angiotensinogen	Rattus norvegicus	162-176
24157579-2	2014	In this study, the effect of ethyl acetate extract of Nan Mu Xiang (NMX) on cardiac fibrosis was assessed in vitro by cultured adult rat cardiac fibroblasts with angiotensin II (AngII) stimulation, and in vivo by rats with abdominal aorta constriction (AAC).	ethyl acetate	29-42	angiotensinogen	Rattus norvegicus	178-183
24175616-2	2013	This work details an ab initio and chemical kinetic study of the hydrogen atom abstraction reactions by the hydroperoxyl radical (HO2) on the following esters: methyl ethanoate, methyl propanoate, methyl butanoate, methyl pentanoate, methyl isobutyrate, ethyl ethanoate, propyl ethanoate, and isopropyl ethanoate.	ethyl acetate	161-176	heme oxygenase 2	Homo sapiens	130-133
23173971-2	2014	ether, ethyl acetate, n-hexane, dichloromethane and aqueous extracts of various species of medicinal plants have shown significant in-vivo and in-vitro pharmacological activities against ecto, endo and haemoparasites.	ethyl acetate	7-20	tripartite motif containing 33	Homo sapiens	187-191
24744815-4	2014	Comparing anti-inflammatory effects of these extracts, we found that ethyl acetate extract of this herb (EAFA) exhibited the strongest inhibitory effect on nitric oxide (NO) production in LPS/IFN gamma -stimulated RAW264.7 cells.	ethyl acetate	69-82	interferon gamma	Mus musculus	192-201
24176745-2	2014	DPT and IS were extracted with ethyl acetate, and the chromatographic separation was accomplished by using a Waters Symmetry C18 analytical column (2.1mmx150mm, 5mum) with a mobile phase consisting of acetonitrile and deionized water (70:30, v:v) containing 0.1% formic acid at a flow rate of 0.2mL/min.	ethyl acetate	31-44	dermatopontin	Rattus norvegicus	0-10
24514562-0	2014	Characterization and antioxidant properties of six Algerian propolis extracts: ethyl acetate extracts inhibit myeloperoxidase activity.	ethyl acetate	79-92	myeloperoxidase	Homo sapiens	110-125
24514562-2	2014	Ethyl acetate extracts of propolis from several Algerian regions show high activity by scavenging free radicals, preventing lipid peroxidation and inhibiting myeloperoxidase (MPO).	ethyl acetate	0-13	myeloperoxidase	Homo sapiens	158-173
24514562-2	2014	Ethyl acetate extracts of propolis from several Algerian regions show high activity by scavenging free radicals, preventing lipid peroxidation and inhibiting myeloperoxidase (MPO).	ethyl acetate	0-13	myeloperoxidase	Homo sapiens	175-178
24189030-13	2014	CONCLUSIONS: The ethyl acetate fraction from Picea mariana bark extract showed inhibitory effects of cytokines, chemokines, adhesion molecules, nitric oxide and prostaglandins produced by keratinocytes under TNF-alpha activation through down-regulating the NF-kappaB pathway.	ethyl acetate	17-30	tumor necrosis factor	Homo sapiens	208-217
24517259-13	2013	RESULTS: The ethyl acetate extract of C. sativum roots showed the highest antiproliferative activity on MCF-7 cells (IC50 = 200.0 +- 2.6 mug/mL) and had the highest phenolic content, FRAP and DPPH scavenging activities among the extracts.	ethyl acetate	13-26	mechanistic target of rapamycin kinase	Homo sapiens	183-187
24134394-8	2013	Intracellular ROS accumulation resulting from Abeta treatment in PC12 cells was significantly reduced when ethyl acetate fractions were presented in the medium compare to PC12 cells which was only treated with Abeta only.	ethyl acetate	107-120	amyloid beta precursor protein	Rattus norvegicus	46-51
23981377-6	2013	Among the entire fraction tested, Hex-EtOAc (75:25) showed cytotoxic effects on the two cell lines and EtOAc fraction was most active only HL-60 cells (12 mug/ml).	ethyl acetate	38-43	hematopoietically expressed homeobox	Homo sapiens	34-37
24134394-8	2013	Intracellular ROS accumulation resulting from Abeta treatment in PC12 cells was significantly reduced when ethyl acetate fractions were presented in the medium compare to PC12 cells which was only treated with Abeta only.	ethyl acetate	107-120	amyloid beta precursor protein	Rattus norvegicus	210-215
24134394-9	2013	Ethyl acetate fractions from aged garlic extracts showed protection against Abeta-induced neurotoxicity.	ethyl acetate	0-13	amyloid beta precursor protein	Rattus norvegicus	76-81
23971790-7	2013	The Payena dasyphylla methanolic bark extract was then fractionated into several fractions in where the ethyl acetate (EA) fraction was evaluated for its inhibitory effects on the HYAL1 and HYAL2 gene expressions using reverse transcription-polymerase chain reaction (RT-PCR) technique.	ethyl acetate	104-117	hyaluronidase 1	Homo sapiens	180-185
23995554-3	2013	The optimum performance was obtained with Cu/CeO2 catalyst, which offers complete conversion of ethyl acetate into CO2 at temperatures as low as 260 C. The catalytic performance of Cu/Ce1-xSmxOdelta was interpreted on the basis of characterization studies, showing that incorporation of samarium in ceria has a detrimental effect on the textural characteristics and reducibility of catalysts.	ethyl acetate	96-109	carboxylesterase 1	Homo sapiens	184-187
23827758-8	2013	RESULTS: Ethyl acetate extract of Aegle marmelos inhibited rat lens AR in vitro with an IC50 value of   15 microg/ml.	ethyl acetate	9-22	aldo-keto reductase family 1 member B1	Rattus norvegicus	68-70
23827758-10	2013	Supplementation of ethyl acetate extract of Aegle marmelos to STZ-induced diabetic rats decreased the blood glucose levels due to hyperglycemia and inhibited the AR activity and delayed cataract progression in dose dependent manner.	ethyl acetate	19-32	aldo-keto reductase family 1 member B1	Rattus norvegicus	162-164
23971790-7	2013	The Payena dasyphylla methanolic bark extract was then fractionated into several fractions in where the ethyl acetate (EA) fraction was evaluated for its inhibitory effects on the HYAL1 and HYAL2 gene expressions using reverse transcription-polymerase chain reaction (RT-PCR) technique.	ethyl acetate	104-117	hyaluronidase 2	Homo sapiens	190-195
23827758-12	2013	CONCLUSION: This study indicates that ethyl acetate extract of Aegle marmelos has pharmacologically active components with a potential to inhibit rat lens AR and consequential decrease in osmotic stress.	ethyl acetate	38-51	aldo-keto reductase family 1 member B1	Rattus norvegicus	155-157
23971790-7	2013	The Payena dasyphylla methanolic bark extract was then fractionated into several fractions in where the ethyl acetate (EA) fraction was evaluated for its inhibitory effects on the HYAL1 and HYAL2 gene expressions using reverse transcription-polymerase chain reaction (RT-PCR) technique.	ethyl acetate	119-121	hyaluronidase 1	Homo sapiens	180-185
23971790-7	2013	The Payena dasyphylla methanolic bark extract was then fractionated into several fractions in where the ethyl acetate (EA) fraction was evaluated for its inhibitory effects on the HYAL1 and HYAL2 gene expressions using reverse transcription-polymerase chain reaction (RT-PCR) technique.	ethyl acetate	119-121	hyaluronidase 2	Homo sapiens	190-195
23971790-12	2013	Similarly, treatment with Payena dasyphylla ethyl acetate (EA) fraction (100 mug/ml) inhibited the HYAL1 and HYAL2 mRNA gene expressions as well as MMP-3 and MMP-13 protein expression in a dose dependent manner.	ethyl acetate	59-61	hyaluronidase 1	Homo sapiens	99-104
23971790-12	2013	Similarly, treatment with Payena dasyphylla ethyl acetate (EA) fraction (100 mug/ml) inhibited the HYAL1 and HYAL2 mRNA gene expressions as well as MMP-3 and MMP-13 protein expression in a dose dependent manner.	ethyl acetate	59-61	hyaluronidase 2	Homo sapiens	109-114
23971790-12	2013	Similarly, treatment with Payena dasyphylla ethyl acetate (EA) fraction (100 mug/ml) inhibited the HYAL1 and HYAL2 mRNA gene expressions as well as MMP-3 and MMP-13 protein expression in a dose dependent manner.	ethyl acetate	59-61	matrix metallopeptidase 3	Homo sapiens	148-153
23971790-12	2013	Similarly, treatment with Payena dasyphylla ethyl acetate (EA) fraction (100 mug/ml) inhibited the HYAL1 and HYAL2 mRNA gene expressions as well as MMP-3 and MMP-13 protein expression in a dose dependent manner.	ethyl acetate	59-61	matrix metallopeptidase 13	Homo sapiens	158-164
24064447-3	2013	Isoorientin (3) and the EtOAc extract showed the greatest antioxidant activity in the DPPH assay as well as the strongest inhibition of xanthine oxidase (XO) and 15-lipoxygenase (15-LO).	ethyl acetate	24-29	arachidonate 15-lipoxygenase	Homo sapiens	162-177
23561137-3	2013	The petroleum ether and ethyl acetate fractions were found to have significant inhibition effects on NO production and NF-kappaB luciferase activity in macrophage RAW 264.7 cells and cytotoxicity against human prostatic carcinoma cell PC3 and breast carcinoma cell MDA-MB-231.	ethyl acetate	24-37	chromobox 8	Homo sapiens	235-238
23957353-8	2013	Induction of G0/G1 cell cycle arrest on human colon carcinoma cell was observed in CBR EtOAc fraction-treated cells.	ethyl acetate	87-92	cannabinoid receptor 1	Homo sapiens	83-86
23743049-1	2013	The formation of active sites in the silica supported copper and cerium oxide bi-component catalysts for total oxidation of ethyl acetate was studied by Nitrogen physisorption, XRD, XPS, UV-Vis, Raman, FTIR of adsorbed CO spectroscopies and TPR.	ethyl acetate	124-137	translocated promoter region, nuclear basket protein	Homo sapiens	241-244
23647018-2	2013	The enriched bamboo shoot angiotensin converting enzyme (ACE) inhibitory peptide preparation fraction (called BSP for short) was extracted with ethyl acetate and n-butanol.	ethyl acetate	144-157	angiotensin I converting enzyme	Rattus norvegicus	57-60
24716175-7	2013	It was found that administration of ethyl acetate fraction (200 and 400 mg/kg) produced a significant (P &lt; 0.001) fall in fasting blood glucose level, TBARS, bilirubin, AST, ALT, and SALP, while elevating the GSH levels, and SOD and CAT activities in diabetic rats.	ethyl acetate	36-49	catalase	Rattus norvegicus	236-239
23647018-3	2013	The ethyl acetate fraction and n-butanol fraction exhibited higher antioxidant capacities than the leaving water fraction (BSML), which was attributed to the higher phenolic acid and flavonoid content of both fractions, while BSML exhibited the strongest ACE inhibitory activity.	ethyl acetate	4-17	angiotensin I converting enzyme	Rattus norvegicus	255-258
24380267-7	2013	RESULTS: The study showed that exposure of CBRH7919 (Jneo3-5B) cells to ethyl acetate extract of A. trewioides resulted in a concentration-dependent inhibition of subgenomic HCV RNA replication and NS3 protein expression ability among the four extracts (P &lt; 0.05).	ethyl acetate	72-85	KRAS proto-oncogene, GTPase	Homo sapiens	198-201
23411266-3	2013	Furthermore, the content of thiobarbituric acid-reactive substances (TBARS), and catalase and superoxide dismutase (SOD) in liver, heart and kidney decreased significantly after oral administration of the ethyl acetate extract, compared with those of HCD-fed rats.	ethyl acetate	205-218	catalase	Rattus norvegicus	81-89
24380267-11	2013	CONCLUSION: The ethyl acetate extract of A. trewioides is the activity fraction which can significantly interfere with subgenomic HCV RNA replication and expression of NS3 protein in vitro.	ethyl acetate	16-29	KRAS proto-oncogene, GTPase	Homo sapiens	168-171
23435602-6	2013	An ethyl acetate (EtOAc) extract exhibited the highest cytotoxicity and resulted in an up-regulated expression of the pro-apoptotic protein Bax (bcl-2 associated X protein) and a down-regulated expression of the anti-apoptotic protein Bcl2 in both SW480 and MCF7 cells.	ethyl acetate	3-16	BCL2 associated X, apoptosis regulator	Homo sapiens	140-143
23529836-4	2013	The use of relatively fast-extracting ethyl acetate and slowly extracting dichloromethane as shell- and core-phase solvents, respectively, was found to produce DWMS with well-defined core-shell structure, high BSA encapsulation efficiency, and the desired localization of protein in the particle core.	ethyl acetate	38-51	albumin	Homo sapiens	210-213
23631356-5	2013	RESULTS: The results indicate that (50, 100 mug/mL) methanol and ethyl acetate fractionation extracts of PY not only inhibited LPS-mediated NO production and iNOS expression, but also decreased LPS-induced PGE2 production and COX-2 expression.	ethyl acetate	65-78	nitric oxide synthase 2, inducible	Mus musculus	158-162
23631356-5	2013	RESULTS: The results indicate that (50, 100 mug/mL) methanol and ethyl acetate fractionation extracts of PY not only inhibited LPS-mediated NO production and iNOS expression, but also decreased LPS-induced PGE2 production and COX-2 expression.	ethyl acetate	65-78	prostaglandin-endoperoxide synthase 2	Mus musculus	226-231
23631356-7	2013	LPS-induced nuclear translocation of NF-kappaB decreased significantly by the methanol extract and ethyl acetate fraction of PY.	ethyl acetate	99-112	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-46
23435602-6	2013	An ethyl acetate (EtOAc) extract exhibited the highest cytotoxicity and resulted in an up-regulated expression of the pro-apoptotic protein Bax (bcl-2 associated X protein) and a down-regulated expression of the anti-apoptotic protein Bcl2 in both SW480 and MCF7 cells.	ethyl acetate	3-16	BCL2 apoptosis regulator	Homo sapiens	235-239
23435602-6	2013	An ethyl acetate (EtOAc) extract exhibited the highest cytotoxicity and resulted in an up-regulated expression of the pro-apoptotic protein Bax (bcl-2 associated X protein) and a down-regulated expression of the anti-apoptotic protein Bcl2 in both SW480 and MCF7 cells.	ethyl acetate	18-23	BCL2 associated X, apoptosis regulator	Homo sapiens	140-143
23435602-6	2013	An ethyl acetate (EtOAc) extract exhibited the highest cytotoxicity and resulted in an up-regulated expression of the pro-apoptotic protein Bax (bcl-2 associated X protein) and a down-regulated expression of the anti-apoptotic protein Bcl2 in both SW480 and MCF7 cells.	ethyl acetate	18-23	BCL2 apoptosis regulator	Homo sapiens	235-239
23435602-8	2013	Furthermore, incubation of cells with the EtOAc extract down-regulated the expression of inflammatory molecules such as cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS) in SW480 cells but not in MCF7 cells.	ethyl acetate	42-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-136
23435602-8	2013	Furthermore, incubation of cells with the EtOAc extract down-regulated the expression of inflammatory molecules such as cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS) in SW480 cells but not in MCF7 cells.	ethyl acetate	42-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	138-142
23228932-3	2013	Paraoxonase 1 (PON1) and Aryl hydrocarbon receptor (AhR) siRNA transfections inhibited the induction of gene expressions by ASA suggesting the need for the acetyl ester hydrolysis and hydroxylation to DHBA.	ethyl acetate	156-168	paraoxonase 1	Homo sapiens	0-13
23433072-8	2013	Phytochemical and chemotaxis assays showed that the crude extract, ethyl acetate fraction and oxyresveratrol from M. alba suppressed cell migration of Jurkat T cells in response to SDF-1.	ethyl acetate	67-80	C-X-C motif chemokine ligand 12	Homo sapiens	181-186
23798888-10	2013	The biochemical parameters such as catalase, glutathione contents showed a significant increase while the lipid peroxide and Cathepsin-D content decreased significantly only in case of ethyl acetate pretreated rats when compared to others.	ethyl acetate	185-198	cathepsin D	Rattus norvegicus	125-136
23538870-1	2013	In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species.	ethyl acetate	91-104	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	148-151
23228932-3	2013	Paraoxonase 1 (PON1) and Aryl hydrocarbon receptor (AhR) siRNA transfections inhibited the induction of gene expressions by ASA suggesting the need for the acetyl ester hydrolysis and hydroxylation to DHBA.	ethyl acetate	156-168	aryl hydrocarbon receptor	Homo sapiens	25-50
23228932-3	2013	Paraoxonase 1 (PON1) and Aryl hydrocarbon receptor (AhR) siRNA transfections inhibited the induction of gene expressions by ASA suggesting the need for the acetyl ester hydrolysis and hydroxylation to DHBA.	ethyl acetate	156-168	aryl hydrocarbon receptor	Homo sapiens	52-55
23548129-4	2013	This study aims to determine the mechanism of anti-inflammatory activities of ethyl acetate fraction of ACE (EA-ACE) using a model of lambda-carrageenan (Carr)-induced paw edema in mouse model.	ethyl acetate	78-91	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	104-107
23548129-4	2013	This study aims to determine the mechanism of anti-inflammatory activities of ethyl acetate fraction of ACE (EA-ACE) using a model of lambda-carrageenan (Carr)-induced paw edema in mouse model.	ethyl acetate	78-91	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	109-115
23228932-3	2013	Paraoxonase 1 (PON1) and Aryl hydrocarbon receptor (AhR) siRNA transfections inhibited the induction of gene expressions by ASA suggesting the need for the acetyl ester hydrolysis and hydroxylation to DHBA.	ethyl acetate	156-168	paraoxonase 1	Homo sapiens	15-19
23864896-2	2013	Ethyl acetate (EtOAc) and chloroform extracts inhibited in vitro neuraminidase (NA) enzymatic activity and viral replication more than methanol (MeOH) extract.	ethyl acetate	0-13	neuraminidase 1	Homo sapiens	65-78
24117075-4	2013	Our results showed that one subfraction of the EA extract (EA6) was cytotoxic to nasopharyngeal carcinoma (NPC) CNE-1 cells, among all cell lines evaluated.	ethyl acetate	47-49	solute carrier family 1 member 3	Homo sapiens	59-62
23864896-2	2013	Ethyl acetate (EtOAc) and chloroform extracts inhibited in vitro neuraminidase (NA) enzymatic activity and viral replication more than methanol (MeOH) extract.	ethyl acetate	15-20	neuraminidase 1	Homo sapiens	65-78
23533475-7	2013	CBR EtOAc treatment increased melanin content and melanogenesis-related proteins of MITF and TRP-1 expressions, which supports its anticancer activity.	ethyl acetate	4-9	cannabinoid receptor 1 (brain)	Mus musculus	0-3
23533475-7	2013	CBR EtOAc treatment increased melanin content and melanogenesis-related proteins of MITF and TRP-1 expressions, which supports its anticancer activity.	ethyl acetate	4-9	tyrosinase-related protein 1	Mus musculus	93-98
23533475-9	2013	In melanoma-xenografted mouse model, melanoma tumor growth was significantly suppressed under CBR EtOAc fraction treatment.	ethyl acetate	98-103	cannabinoid receptor 1 (brain)	Mus musculus	94-97
22407769-4	2012	In the course of screening for natural BACE1 inhibitors from Corni fructus, the ethyl acetate (EtOAc) fraction showed significant inhibitory activity against BACE1.	ethyl acetate	80-93	beta-secretase 1	Homo sapiens	39-44
23418674-7	2013	The results suggested that both the EtOAc extract and berberine were able to activate PPARalpha/beta/gamma, and Rhizoma Coptis contains potential natural agonists of PPARs besides berberine.	ethyl acetate	36-41	peroxisome proliferator activated receptor alpha	Homo sapiens	86-126
23134459-5	2012	In addition, the ethyl acetate fraction improved in vivo cognitive ability against amyloid beta-peptide (Abeta)-induced neuronal deficit.	ethyl acetate	17-30	amyloid beta precursor protein	Rattus norvegicus	105-110
22868104-5	2012	Ethyl acetate extract of peel reduced expression of inducible nitric oxide synthase, but enhanced expression of cyclooxygenase 2.	ethyl acetate	0-13	prostaglandin-endoperoxide synthase 2	Mus musculus	112-128
22900549-11	2012	The EtOAc extracts seems to be the most potent antioxidant at 100 microg/mL (SOD activity 173.736 +- 8.33, CAT activity 133.218 +- 3.31, GSH level 2.264 +- 2.21).	ethyl acetate	4-9	catalase	Homo sapiens	107-110
22407769-4	2012	In the course of screening for natural BACE1 inhibitors from Corni fructus, the ethyl acetate (EtOAc) fraction showed significant inhibitory activity against BACE1.	ethyl acetate	80-93	beta-secretase 1	Homo sapiens	158-163
22407769-4	2012	In the course of screening for natural BACE1 inhibitors from Corni fructus, the ethyl acetate (EtOAc) fraction showed significant inhibitory activity against BACE1.	ethyl acetate	95-100	beta-secretase 1	Homo sapiens	39-44
22407769-4	2012	In the course of screening for natural BACE1 inhibitors from Corni fructus, the ethyl acetate (EtOAc) fraction showed significant inhibitory activity against BACE1.	ethyl acetate	95-100	beta-secretase 1	Homo sapiens	158-163
23022187-5	2012	Consequently, EA decreased the production of, TNF alpha and the inflammatory agent nitric oxide (NO) in RAW264.7 cells treated with LPS.	ethyl acetate	14-16	tumor necrosis factor	Mus musculus	46-55
21854107-0	2012	Inhibition of LPS-induced inflammatory biomarkers by ethyl acetate fraction of Patrinia scabiosaefolia through suppression of NF-kappaB activation in RAW 264.7 cells.	ethyl acetate	53-66	toll-like receptor 4	Mus musculus	14-17
22350144-8	2012	The c-fos expression was also confirmed by in vivo fluorescent staining of CCD-986sk cells after UV-B exposure followed by EtOAc extract treatment.	ethyl acetate	123-128	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
23035451-7	2012	The ethyl acetate soluble fraction showed higher activities (DPPH radical scavenging, metal ion chelating and tyrosinase inhibition) than the crude extract of 23.48, 71.80 and 2.58 times, respectively.	ethyl acetate	4-17	tyrosinase	Homo sapiens	110-120
29243623-1	2012	The ethyl acetate and methanol extracts from 16 Salvia L. species were screened for their inhibitory activity against acetylcholinesterase, butyrylcholinesterase, lipoxygenase, and tyrosinase; the enzymes linked to neurodegeneration.	ethyl acetate	4-17	tyrosinase	Homo sapiens	181-191
22366406-5	2012	The results in these studies demonstrated the immunostimulatory effect of PNRS-EtOAC in a dose-dependent manner with respect to the macrophage activation possibly expressing the phagocytosis and nitrite production by the enhancement of TNF-alpha production as a mode of action.	ethyl acetate	79-84	tumor necrosis factor	Mus musculus	236-245
24116298-2	2012	In our previous research, the ethyl acetate fraction of G. jasminosides fruits inhibited the activities of both monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B), and oral administration of the ethanolic extract slightly increased serotonin concentrations in the brain tissues of rats and decreased MAO-B activity.	ethyl acetate	30-43	monoamine oxidase A	Rattus norvegicus	112-131
24116298-2	2012	In our previous research, the ethyl acetate fraction of G. jasminosides fruits inhibited the activities of both monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B), and oral administration of the ethanolic extract slightly increased serotonin concentrations in the brain tissues of rats and decreased MAO-B activity.	ethyl acetate	30-43	monoamine oxidase A	Rattus norvegicus	133-138
24116298-2	2012	In our previous research, the ethyl acetate fraction of G. jasminosides fruits inhibited the activities of both monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B), and oral administration of the ethanolic extract slightly increased serotonin concentrations in the brain tissues of rats and decreased MAO-B activity.	ethyl acetate	30-43	monoamine oxidase B	Rattus norvegicus	144-163
24116298-2	2012	In our previous research, the ethyl acetate fraction of G. jasminosides fruits inhibited the activities of both monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B), and oral administration of the ethanolic extract slightly increased serotonin concentrations in the brain tissues of rats and decreased MAO-B activity.	ethyl acetate	30-43	monoamine oxidase B	Rattus norvegicus	165-170
24116298-2	2012	In our previous research, the ethyl acetate fraction of G. jasminosides fruits inhibited the activities of both monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B), and oral administration of the ethanolic extract slightly increased serotonin concentrations in the brain tissues of rats and decreased MAO-B activity.	ethyl acetate	30-43	monoamine oxidase B	Rattus norvegicus	309-314
21854107-4	2012	The results indicated that the ethyl acetate fraction of PS (EAPS) concentration highly suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) and IL-6 productions without a cytotoxic effect on RAW 264.7 cells.	ethyl acetate	31-44	toll-like receptor 4	Mus musculus	119-122
21854107-4	2012	The results indicated that the ethyl acetate fraction of PS (EAPS) concentration highly suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) and IL-6 productions without a cytotoxic effect on RAW 264.7 cells.	ethyl acetate	31-44	interleukin 6	Mus musculus	154-158
22350499-3	2012	The highest DPPH and tyrosinase inhibition activities were registered in ethyl acetate (EtOAc) extract.	ethyl acetate	73-86	tyrosinase	Homo sapiens	21-31
22350499-3	2012	The highest DPPH and tyrosinase inhibition activities were registered in ethyl acetate (EtOAc) extract.	ethyl acetate	88-93	tyrosinase	Homo sapiens	21-31
21982436-3	2012	Further liquid-liquid partition revealed an ethyl acetate phase with potent reduction of ICAM-1 expression to 40% at 8 mug/ml.	ethyl acetate	44-57	intercellular adhesion molecule 1	Homo sapiens	89-95
22631633-0	2012	Chemopreventive potential of an ethyl acetate fraction from Curcuma longa is associated with upregulation of p57(kip2) and Rad9 in the PC-3M prostate cancer cell line.	ethyl acetate	32-45	cyclin dependent kinase inhibitor 1C	Homo sapiens	109-112
22154966-11	2012	All the EtOAc extracts exhibited percentage inhibition in the range of 50.7-94.7% against COX-1 and -2 enzymes at 250 mug/mL.	ethyl acetate	8-13	cytochrome c oxidase subunit I	Caenorhabditis elegans	90-102
22170388-6	2012	Ethyl acetate solvate 2 behaves as an antiferromagnetic chain without ordering or slow magnetic relaxation down to 0.5 K. The magnetic susceptibility data chi(M) T (20-300 K) of 2 was fitted by assuming the spin Hamiltonian H = -2JSigma(i=1)(n-1) S(Ai) S(Ai+1), and the intrachain antiferromagnetic coupling constant of -0.07 cm(-1) is much weaker than that of 1.	ethyl acetate	0-13	spindlin 1	Homo sapiens	207-211
22631633-0	2012	Chemopreventive potential of an ethyl acetate fraction from Curcuma longa is associated with upregulation of p57(kip2) and Rad9 in the PC-3M prostate cancer cell line.	ethyl acetate	32-45	cyclin dependent kinase inhibitor 1C	Homo sapiens	113-117
22631633-0	2012	Chemopreventive potential of an ethyl acetate fraction from Curcuma longa is associated with upregulation of p57(kip2) and Rad9 in the PC-3M prostate cancer cell line.	ethyl acetate	32-45	RAD9 checkpoint clamp component A	Homo sapiens	123-127
22631633-9	2012	CONCLUSIONS: From these observations it was concluded that the ethyl acetate fraction showed not only inhibition of colony forming ability of PC-3M cells but also up-regulated cell cycle genes p57(kip2) and Rad9 and further reduced the migration and invasive ability of prostate cancer cells.	ethyl acetate	63-76	cyclin dependent kinase inhibitor 1C	Homo sapiens	193-196
22631633-9	2012	CONCLUSIONS: From these observations it was concluded that the ethyl acetate fraction showed not only inhibition of colony forming ability of PC-3M cells but also up-regulated cell cycle genes p57(kip2) and Rad9 and further reduced the migration and invasive ability of prostate cancer cells.	ethyl acetate	63-76	cyclin dependent kinase inhibitor 1C	Homo sapiens	197-201
22631633-9	2012	CONCLUSIONS: From these observations it was concluded that the ethyl acetate fraction showed not only inhibition of colony forming ability of PC-3M cells but also up-regulated cell cycle genes p57(kip2) and Rad9 and further reduced the migration and invasive ability of prostate cancer cells.	ethyl acetate	63-76	RAD9 checkpoint clamp component A	Homo sapiens	207-211
22687398-0	2012	Effects of the ethylacetate extract of Orostachys japonicus on induction of apoptosis through the p53-mediated signaling pathway in human gastric cancer cells.	ethyl acetate	15-27	tumor protein p53	Homo sapiens	98-101
22293351-3	2012	The ethyl acetate-soluble fraction of MCS-ext was the most potent inhibitor of MMP-1 secretion.	ethyl acetate	4-17	matrix metallopeptidase 1	Homo sapiens	79-84
24116280-8	2012	EtOAc extract of PTF recovered the levels of ALP activity, and the expression of OPN and OPG in MC3T3-E1 cells treated with DEX.	ethyl acetate	0-5	secreted phosphoprotein 1	Mus musculus	81-84
24116280-8	2012	EtOAc extract of PTF recovered the levels of ALP activity, and the expression of OPN and OPG in MC3T3-E1 cells treated with DEX.	ethyl acetate	0-5	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	89-92
24116280-9	2012	In osteoclast differentiation, multinucleated TRAP-positive cell formation was significantly suppressed by the EtOAc extract of PTF.	ethyl acetate	111-116	acid phosphatase 5, tartrate resistant	Mus musculus	46-50
22063737-0	2012	Anti-inflammatory potential of an ethyl acetate fraction isolated from Justicia gendarussa roots through inhibition of iNOS and COX-2 expression via NF-kappaB pathway.	ethyl acetate	34-47	nuclear factor kappa B subunit 1	Homo sapiens	149-158
22919411-3	2012	The ethyl acetate fraction inhibited TARC, macrophage-derived chemokine (MDC/CCL22), and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in HaCaT cells better than the other fractions.	ethyl acetate	4-17	C-C motif chemokine ligand 17	Homo sapiens	37-41
22382318-4	2012	Ethyl acetate extracts of the tomato juices moderately reduced residual activity of CYP3A4 testosterone 6beta-hydroxylation activity by 19.3-26.2% with 0-min preincubation.	ethyl acetate	0-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-90
22863933-2	2012	Atractylenolide III, which promoted Gli1-mediated transcriptional activity, was isolated from an ethyl acetate extract of the Rhizoma, Atractylodis macrocephalae.	ethyl acetate	97-110	GLI family zinc finger 1	Homo sapiens	36-40
22919411-3	2012	The ethyl acetate fraction inhibited TARC, macrophage-derived chemokine (MDC/CCL22), and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in HaCaT cells better than the other fractions.	ethyl acetate	4-17	C-C motif chemokine ligand 22	Homo sapiens	43-71
22919411-3	2012	The ethyl acetate fraction inhibited TARC, macrophage-derived chemokine (MDC/CCL22), and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in HaCaT cells better than the other fractions.	ethyl acetate	4-17	C-C motif chemokine ligand 22	Homo sapiens	73-76
22919411-3	2012	The ethyl acetate fraction inhibited TARC, macrophage-derived chemokine (MDC/CCL22), and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in HaCaT cells better than the other fractions.	ethyl acetate	4-17	C-C motif chemokine ligand 22	Homo sapiens	77-82
22919411-3	2012	The ethyl acetate fraction inhibited TARC, macrophage-derived chemokine (MDC/CCL22), and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in HaCaT cells better than the other fractions.	ethyl acetate	4-17	C-C motif chemokine ligand 5	Homo sapiens	155-161
22919411-3	2012	The ethyl acetate fraction inhibited TARC, macrophage-derived chemokine (MDC/CCL22), and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in HaCaT cells better than the other fractions.	ethyl acetate	4-17	C-C motif chemokine ligand 5	Homo sapiens	162-166
22593683-6	2012	The 14-day repeated oral administration of the ethyl acetate fraction significantly reduced the fasting blood glucose and pancreatic TBARS level and significantly increased the liver glycogen, pancreatic superoxide dismutase, and catalase activities as well as reduced glutathione levels.	ethyl acetate	47-60	catalase	Rattus norvegicus	230-238
22004473-3	2012	All the concentrations (3.125-200 mg mL-1) of chloroform, ethyl acetate and n-butanol fractions of leaf extract, and n-hexane fraction of fruit extract completely inhibited the target fungal growth.	ethyl acetate	58-71	L1 cell adhesion molecule	Mus musculus	37-41
22007784-6	2012	All the concentrations (3.125-200 mg mL-1) of ethyl acetate fraction completely inhibited the target fungal growth.	ethyl acetate	46-59	L1 cell adhesion molecule	Mus musculus	37-41
22375875-1	2012	In vitro anti-allergic screening of medicinal herbal extracts revealed that the EtOAc extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-gamma activated murine macrophage-like cell line, RAW264.7.	ethyl acetate	80-85	interferon gamma	Mus musculus	214-230
21515352-3	2011	MATERIALS AND METHODS: Anti-proliferative activity of ethyl acetate extracts of P. angulata (PA extracts), was determined against human oral squamous carcinoma (HSC-3) and human umbilical vein endothelial cells (HUVECs) by trypan blue exclusion method.	ethyl acetate	54-67	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	161-166
21895456-3	2012	The ethyl acetate extract exhibited a potent inhibitory effect against WNV"s RdRp, with an IC50 value of 8 microg mL-1.	ethyl acetate	4-17	L1 cell adhesion molecule	Mus musculus	114-118
21919561-5	2012	Promising GI50 values of 1.96, 4.34 and 4.65 microg mL-1 were observed for the extract, its chloroform and ethyl acetate fractions, respectively.	ethyl acetate	107-120	L1 cell adhesion molecule	Mus musculus	52-56
21892616-4	2011	Among fractions, ethyl acetate fraction (EF) and n-butanol extract (BF) exhibited potent hepatoprotective activities (62.60% for EF and 64.86% for BF) in t-BHP-injured HepG2 cells at a concentration of 10 mug/mL-1.	ethyl acetate	17-30	L1 cell adhesion molecule	Mus musculus	209-213
21797203-6	2011	The chlorine atom initiated oxidation of ethyl acetate in N(2)/O(2) diluent gave acetic acid, acetic acid anhydride, acetic formic anhydride, formaldehyde, and, in the presence of NO(x), PAN.	ethyl acetate	41-54	adenosine deaminase 2	Homo sapiens	187-190
20929426-1	2011	We evaluated the ability of the ethylacetate fraction of marine sponge, Cliona celata (ECC), harvested from Korean seaside to regulate the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated murine macrophage-like RAW264.7 cells.	ethyl acetate	32-44	nitric oxide synthase 2, inducible	Mus musculus	186-190
21849150-7	2011	CONCLUSION: Ethyl acetate extract of Plastrum Testudinis inhibits epidermal stem cell apoptosis in serum-deprived culture by regulating the expressions of Bcl-2 and caspase-3 proteins and has a stronger anti-apoptotic effect than its constituents S6, S8 and S9.	ethyl acetate	12-25	BCL2, apoptosis regulator	Rattus norvegicus	155-160
21849150-7	2011	CONCLUSION: Ethyl acetate extract of Plastrum Testudinis inhibits epidermal stem cell apoptosis in serum-deprived culture by regulating the expressions of Bcl-2 and caspase-3 proteins and has a stronger anti-apoptotic effect than its constituents S6, S8 and S9.	ethyl acetate	12-25	caspase 3	Rattus norvegicus	165-174
21518732-6	2011	CM-H(2)DCFDA [5 (and 6)-chloromethyl-2",7"-dichlorodihydrofluorescein diacetate, acetyl ester] fluorescence and aconitase activity showed an increase in reactive oxygen species levels in CFTR-defective cells and a pro-oxidative environment within CF mitochondria.	ethyl acetate	81-93	CF transmembrane conductance regulator	Homo sapiens	187-191
21554130-5	2011	The ethyl-acetate extract and the compound fukugetin showed significant activity as inhibitors of Leishmania"s proteases, with mean (+-SD) IC(50) (50% inhibition concentration of protease activity) values of 15.0+-1.3 mug/mL and 3.2+-0.5 muM/mL, respectively, characterizing a bioguided assay.	ethyl acetate	4-17	latexin	Homo sapiens	238-241
21860589-2	2011	During a screening procedure on medicinal plants, the ethylacetate extract of the lignum of C. sappan (CLE) showed inhibitory activity on arginase which has recently been reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis.	ethyl acetate	54-66	closed eyes and microphthalmia	Mus musculus	103-106
21276846-3	2011	The ethylacetate fraction from starfish, Asterias amurensis (EFA), harvested from the Korean seaside has an inhibitory effect on MMP-9 and MMP-2 activities, as well as on the expression of MMP-9 in TNF-alpha induced HASMC in a dose-dependent manner.	ethyl acetate	4-16	matrix metallopeptidase 2	Homo sapiens	139-144
25213920-6	2011	The n-hexane fraction of the propolis extract sample, and the ethyl acetate fractions of the other samples, showed AhR activity similar to that of TCDD, at a high concentration range.	ethyl acetate	62-75	aryl hydrocarbon receptor	Homo sapiens	115-118
21815418-4	2011	All tested extracts exhibited moderate activity against HeLa cells (41.9-42.1 microg/mL), whereas the extract obtained with 100% ethyl acetate was the most active against K562 and PC3 cell lines (25.9 and 39.2 microg/mL, respectively).	ethyl acetate	129-142	chromobox 8	Homo sapiens	180-183
21276846-3	2011	The ethylacetate fraction from starfish, Asterias amurensis (EFA), harvested from the Korean seaside has an inhibitory effect on MMP-9 and MMP-2 activities, as well as on the expression of MMP-9 in TNF-alpha induced HASMC in a dose-dependent manner.	ethyl acetate	4-16	matrix metallopeptidase 9	Homo sapiens	189-194
21276846-3	2011	The ethylacetate fraction from starfish, Asterias amurensis (EFA), harvested from the Korean seaside has an inhibitory effect on MMP-9 and MMP-2 activities, as well as on the expression of MMP-9 in TNF-alpha induced HASMC in a dose-dependent manner.	ethyl acetate	4-16	tumor necrosis factor	Homo sapiens	198-207
21576411-7	2011	RESULT: Among four fractions, the EtOAc fraction showed the highest tumor-specific cytotoxicity, and inhibited NO production by lipopoly-saccharide (LPS)-stimulated mouse macrophage-like cells and receptor activator for nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis to the greatest extent.	ethyl acetate	34-39	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	197-248
21629182-2	2011	The crude methanol and fractionated extracts (hexane and ethyl acetate) displayed good cytotoxic effects against MCF-7, KB, A549, Ca Ski and HT-29 cell lines, but exerted no damage on the MRC-5 line.	ethyl acetate	57-70	SKI proto-oncogene	Homo sapiens	133-136
21576411-7	2011	RESULT: Among four fractions, the EtOAc fraction showed the highest tumor-specific cytotoxicity, and inhibited NO production by lipopoly-saccharide (LPS)-stimulated mouse macrophage-like cells and receptor activator for nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis to the greatest extent.	ethyl acetate	34-39	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	250-255
21332190-2	2011	A crude ethyl acetate extract, accounting for 8.7% of nonsalt soluble solids of soy sauce, was found to double relative QR specific activity at 25 mug/mL (concentration required to double was defined as a "CD value").	ethyl acetate	8-21	crystallin, zeta	Mus musculus	120-122
21276846-0	2011	Ethylacetate fraction from Korean seaside starfish, Asterias amurensis, has an inhibitory effect on MMP-9 activity and expression and on migration behavior of TNF-alpha induced human aortic smooth muscle cells.	ethyl acetate	0-12	matrix metallopeptidase 9	Homo sapiens	100-105
21276846-0	2011	Ethylacetate fraction from Korean seaside starfish, Asterias amurensis, has an inhibitory effect on MMP-9 activity and expression and on migration behavior of TNF-alpha induced human aortic smooth muscle cells.	ethyl acetate	0-12	tumor necrosis factor	Homo sapiens	159-168
21276846-3	2011	The ethylacetate fraction from starfish, Asterias amurensis (EFA), harvested from the Korean seaside has an inhibitory effect on MMP-9 and MMP-2 activities, as well as on the expression of MMP-9 in TNF-alpha induced HASMC in a dose-dependent manner.	ethyl acetate	4-16	matrix metallopeptidase 9	Homo sapiens	129-134
21300767-2	2011	Of all the extracts tested, chloroform and ethyl acetate extracts of M piperita showed significant dose- and time-dependent anticarcinogenic activity leading to G1 cell cycle arrest and mitochondrial-mediated apoptosis, perturbation of oxidative balance, upregulation of Bax gene, elevated expression of p53 and p21 in the treated cells, acquisition of senescence phenotype, while inducing pro-inflammatory cytokines response.	ethyl acetate	43-56	BCL2 associated X, apoptosis regulator	Homo sapiens	271-274
21300767-2	2011	Of all the extracts tested, chloroform and ethyl acetate extracts of M piperita showed significant dose- and time-dependent anticarcinogenic activity leading to G1 cell cycle arrest and mitochondrial-mediated apoptosis, perturbation of oxidative balance, upregulation of Bax gene, elevated expression of p53 and p21 in the treated cells, acquisition of senescence phenotype, while inducing pro-inflammatory cytokines response.	ethyl acetate	43-56	tumor protein p53	Homo sapiens	304-307
21031336-2	2011	The ethylacetate (EtOAc) layer of the extract has shown an inhibitory effect on beta-hexo release from RBL-2H3 cells at the antigen antibody binding stage.	ethyl acetate	4-16	RB transcriptional corepressor like 2	Rattus norvegicus	103-108
21300767-2	2011	Of all the extracts tested, chloroform and ethyl acetate extracts of M piperita showed significant dose- and time-dependent anticarcinogenic activity leading to G1 cell cycle arrest and mitochondrial-mediated apoptosis, perturbation of oxidative balance, upregulation of Bax gene, elevated expression of p53 and p21 in the treated cells, acquisition of senescence phenotype, while inducing pro-inflammatory cytokines response.	ethyl acetate	43-56	H3 histone pseudogene 16	Homo sapiens	312-315
21031336-2	2011	The ethylacetate (EtOAc) layer of the extract has shown an inhibitory effect on beta-hexo release from RBL-2H3 cells at the antigen antibody binding stage.	ethyl acetate	18-23	RB transcriptional corepressor like 2	Rattus norvegicus	103-108
19745004-0	2011	Inhibitory Effects of Ethyl Acetate Extract of Andrographis paniculata on NF-kappaB Trans-Activation Activity and LPS-Induced Acute Inflammation in Mice.	ethyl acetate	22-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	74-83
20729023-1	2011	A novel peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, KR-62980, was determined by liquid-liquid extraction with ethyl acetate and liquid chromatography-tandem mass spectrometry (LC/MS/MS) in rat plasma.	ethyl acetate	136-149	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	8-56
20729023-1	2011	A novel peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, KR-62980, was determined by liquid-liquid extraction with ethyl acetate and liquid chromatography-tandem mass spectrometry (LC/MS/MS) in rat plasma.	ethyl acetate	136-149	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	58-67
19745004-3	2011	The effects of ethyl acetate (EtOAc) extract from AP on the level of inflammatory mediators were examined first using nuclear factor kappa B (NF-kappaB) driven luciferase assay.	ethyl acetate	15-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-140
19745004-3	2011	The effects of ethyl acetate (EtOAc) extract from AP on the level of inflammatory mediators were examined first using nuclear factor kappa B (NF-kappaB) driven luciferase assay.	ethyl acetate	15-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
19745004-3	2011	The effects of ethyl acetate (EtOAc) extract from AP on the level of inflammatory mediators were examined first using nuclear factor kappa B (NF-kappaB) driven luciferase assay.	ethyl acetate	30-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-140
19745004-3	2011	The effects of ethyl acetate (EtOAc) extract from AP on the level of inflammatory mediators were examined first using nuclear factor kappa B (NF-kappaB) driven luciferase assay.	ethyl acetate	30-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
20801485-8	2010	For example, in a 24-h extraction with acetonitrile of FTS-amended soil, &gt;5wt.% FTOH was produced compared to &lt;0.04wt.% in either ethyl acetate or MTBE.	ethyl acetate	136-149	AKT interacting protein	Homo sapiens	55-58
21423690-0	2011	Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells.	ethyl acetate	12-25	SKI proto-oncogene	Homo sapiens	117-120
22135900-9	2011	The effect of ethyl acetate extract was comparable to the effect of curcumin, a known NF-kappaB pathway inhibitor, and seemed to be the most active inhibitor of H2O2-dependent IkappaBalpha phosphorylation.	ethyl acetate	14-27	nuclear factor kappa B subunit 1	Homo sapiens	86-95
22174656-1	2011	The aim of this study was to investigate the cytoprotective properties of the ethyl acetate fraction of Sargassum muticum (SME) against ultraviolet B (UVB)-induced cell damage in human keratinocytes (HaCaT cells).	ethyl acetate	78-91	small nuclear ribonucleoprotein polypeptide E	Homo sapiens	123-126
21155824-5	2011	The ethyl acetate fraction at 100 microg/ml almost completely suppressed NO production, iNOS and COX-2 expression, and TNF-alpha and IL-6 secretion in cells stimulated with LPS.	ethyl acetate	4-17	nitric oxide synthase 2, inducible	Mus musculus	88-92
21091248-2	2010	Here we show that the ethyl acetate fraction of ginger extract can inhibit the expression of the two prominent molecular targets of cancer, the human telomerase reverse transcriptase (hTERT) and c-Myc, in A549 lung cancer cells in a time- and concentration-dependent manner.	ethyl acetate	22-35	telomerase reverse transcriptase	Homo sapiens	150-182
21091248-2	2010	Here we show that the ethyl acetate fraction of ginger extract can inhibit the expression of the two prominent molecular targets of cancer, the human telomerase reverse transcriptase (hTERT) and c-Myc, in A549 lung cancer cells in a time- and concentration-dependent manner.	ethyl acetate	22-35	telomerase reverse transcriptase	Homo sapiens	184-189
21091248-2	2010	Here we show that the ethyl acetate fraction of ginger extract can inhibit the expression of the two prominent molecular targets of cancer, the human telomerase reverse transcriptase (hTERT) and c-Myc, in A549 lung cancer cells in a time- and concentration-dependent manner.	ethyl acetate	22-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	195-200
21355275-5	2010	On the other hand, extractions of EtoAc and n-BuOH demonstrated dose-dependent inhibition on macrophage NO production stimulated by LPS/IFN-gamma.	ethyl acetate	34-39	interferon gamma	Rattus norvegicus	136-145
20691773-10	2010	PGP EtOAc extract increased a sub-G1 cell population through inducing p53/p21 and activated caspase-8 protein expression in B16F10 cells.	ethyl acetate	4-9	transformation related protein 53, pseudogene	Mus musculus	70-73
20691773-10	2010	PGP EtOAc extract increased a sub-G1 cell population through inducing p53/p21 and activated caspase-8 protein expression in B16F10 cells.	ethyl acetate	4-9	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	74-77
20691773-10	2010	PGP EtOAc extract increased a sub-G1 cell population through inducing p53/p21 and activated caspase-8 protein expression in B16F10 cells.	ethyl acetate	4-9	caspase 8	Mus musculus	92-101
20732400-0	2010	Selective Th1 upregulation by ethyl acetate fraction of Labisia pumila.	ethyl acetate	30-43	negative elongation factor complex member C/D, Th1l	Mus musculus	10-13
20732400-7	2010	CONCLUSION: This study showed ethyl acetate fraction (A001/3b) of Labisia pumila to have Th1 upregulating activity and suggests its possible usefulness as a therapeutic agent in immune compromised patients.	ethyl acetate	30-43	negative elongation factor complex member C/D, Th1l	Mus musculus	89-92
20105050-2	2010	The CSL extracts were found to have a potent scavenging activity against all of the reactive species tested, as well as an inhibitory effect on LDL oxidation, especially in the ethyl acetate (EA) fraction.	ethyl acetate	177-190	chorionic somatomammotropin hormone like 1	Homo sapiens	4-7
20673058-8	2010	The chloroform and ethyl acetate fractions reduced LPS-induced expressions of iNOS and COX-2 and activation of MAP kinases in a dose-dependent manner.	ethyl acetate	19-32	nitric oxide synthase 2, inducible	Mus musculus	78-82
20673058-8	2010	The chloroform and ethyl acetate fractions reduced LPS-induced expressions of iNOS and COX-2 and activation of MAP kinases in a dose-dependent manner.	ethyl acetate	19-32	cytochrome c oxidase II, mitochondrial	Mus musculus	87-92
21506497-4	2010	Hence, in the present study the ethyl acetate extract was screened for hepatoprotective and antioxidant properties against CCl4 induced hepatic injury in rats.	ethyl acetate	32-45	C-C motif chemokine ligand 4	Rattus norvegicus	123-127
20105050-2	2010	The CSL extracts were found to have a potent scavenging activity against all of the reactive species tested, as well as an inhibitory effect on LDL oxidation, especially in the ethyl acetate (EA) fraction.	ethyl acetate	192-194	chorionic somatomammotropin hormone like 1	Homo sapiens	4-7
19998418-6	2010	This study suggests that the ethyl acetate extract of P. linteus grown on PBR induces apoptosis accompanied by cell cycle arrest at G(0)/G(1) phase and regulates apoptosis-regulatory proteins, which may be applicable to anticancer therapy.	ethyl acetate	29-42	translocator protein	Homo sapiens	74-77
21787631-0	2010	Sea cucumber, Stichopus japonicus ethyl acetate fraction modulates the lipopolysaccharide induced iNOS and COX-2 via MAPK signaling pathway in murine macrophages.	ethyl acetate	34-47	nitric oxide synthase 2, inducible	Mus musculus	98-102
21787631-0	2010	Sea cucumber, Stichopus japonicus ethyl acetate fraction modulates the lipopolysaccharide induced iNOS and COX-2 via MAPK signaling pathway in murine macrophages.	ethyl acetate	34-47	COX2	Apostichopus japonicus	107-112
20737911-9	2010	The ethyl acetate fraction exhibited the highest level of AChE inhibition, followed by the dichloromethane fraction.	ethyl acetate	4-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-62
19748164-8	2010	In addition, the EtoAc extract treatments caused significant reduction in the phosphorylated form of JNK along with an increase in the phosphorylated level of ERK1/2.	ethyl acetate	17-22	mitogen-activated protein kinase 8	Rattus norvegicus	101-104
19748164-8	2010	In addition, the EtoAc extract treatments caused significant reduction in the phosphorylated form of JNK along with an increase in the phosphorylated level of ERK1/2.	ethyl acetate	17-22	mitogen activated protein kinase 3	Rattus norvegicus	159-165
20371279-0	2010	Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation.	ethyl acetate	40-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
20371279-4	2010	MATERIALS AND METHODS: NF-kappaB luciferase activity and pro-inflammatory cytokine secretions from lipopolysaccharide (LPS) plus interferon (IFN)-gamma-stimulated RAW 264.7 cells pre-treated with EtOAc extract or compounds were analyzed.	ethyl acetate	196-201	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	23-32
20371279-4	2010	MATERIALS AND METHODS: NF-kappaB luciferase activity and pro-inflammatory cytokine secretions from lipopolysaccharide (LPS) plus interferon (IFN)-gamma-stimulated RAW 264.7 cells pre-treated with EtOAc extract or compounds were analyzed.	ethyl acetate	196-201	interferon gamma	Mus musculus	129-151
20371279-8	2010	RESULTS: The results showed that AS EtOAc extract significantly inhibited NF-kappaB luciferase activity and TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2) and NO secretions from LPS/IFN-gamma-stimulated RAW 264.7 cells.	ethyl acetate	36-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	74-83
20371279-8	2010	RESULTS: The results showed that AS EtOAc extract significantly inhibited NF-kappaB luciferase activity and TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2) and NO secretions from LPS/IFN-gamma-stimulated RAW 264.7 cells.	ethyl acetate	36-41	tumor necrosis factor	Mus musculus	108-117
20371279-8	2010	RESULTS: The results showed that AS EtOAc extract significantly inhibited NF-kappaB luciferase activity and TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2) and NO secretions from LPS/IFN-gamma-stimulated RAW 264.7 cells.	ethyl acetate	36-41	interleukin 6	Mus musculus	119-123
20371279-8	2010	RESULTS: The results showed that AS EtOAc extract significantly inhibited NF-kappaB luciferase activity and TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2) and NO secretions from LPS/IFN-gamma-stimulated RAW 264.7 cells.	ethyl acetate	36-41	chemokine (C-X-C motif) ligand 2	Mus musculus	125-158
20371279-8	2010	RESULTS: The results showed that AS EtOAc extract significantly inhibited NF-kappaB luciferase activity and TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2) and NO secretions from LPS/IFN-gamma-stimulated RAW 264.7 cells.	ethyl acetate	36-41	chemokine (C-X-C motif) ligand 2	Mus musculus	160-165
20371279-8	2010	RESULTS: The results showed that AS EtOAc extract significantly inhibited NF-kappaB luciferase activity and TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2) and NO secretions from LPS/IFN-gamma-stimulated RAW 264.7 cells.	ethyl acetate	36-41	interferon gamma	Mus musculus	194-203
20384131-2	2010	The optimizing experimental conditions were as follows: the mixture of ionic liquid 1-hexyl-3-methylimidazo lium hexafluorophosphats and ethyl acetate ([Hmim] PF6-EA, phi = 1/0.9) can be used as flotation solvent, Fe(III) ion was as trapping agent, pH of test solution was 7.6, the gas flow rate was 40 mL x min(-1), and the flotation time was 50 min.	ethyl acetate	137-150	sperm associated antigen 17	Homo sapiens	159-162
20677645-11	2010	CONCLUSION: Ethyl acetate extract might inhibit proliferation and induce apoptosis in A549 cells via downregulation of EGFR/ERK signal transduction pathway.	ethyl acetate	12-25	epidermal growth factor receptor	Homo sapiens	119-123
20677645-11	2010	CONCLUSION: Ethyl acetate extract might inhibit proliferation and induce apoptosis in A549 cells via downregulation of EGFR/ERK signal transduction pathway.	ethyl acetate	12-25	mitogen-activated protein kinase 1	Homo sapiens	124-127
20051258-0	2010	Insulin releasing and alpha-glucosidase inhibitory activity of ethyl acetate fraction of Acorus calamus in vitro and in vivo.	ethyl acetate	63-76	insulin	Mesocricetus auratus	0-7
20051258-0	2010	Insulin releasing and alpha-glucosidase inhibitory activity of ethyl acetate fraction of Acorus calamus in vitro and in vivo.	ethyl acetate	63-76	sucrase isomaltase (alpha-glucosidase)	Mus musculus	22-39
20051258-1	2010	ETHNOPHARMACOLOGICAL RELEVANCE: The radix of Acorus calamus L. (AC) is widely used in the therapy of diabetes in traditional folk medicine of America and Indonesia, and we previously reported the insulin sensitizing activity of the ethyl acetate fraction of AC (ACE).	ethyl acetate	232-245	insulin	Mesocricetus auratus	196-203
19577456-3	2010	In rat liver microsomes study, the ethyl acetate extract of Danshen, tanshinone I, tanshinone IIA and cryptotanshinone decreased the formation of 4"-, 6- and 7-hydroxy-warfarin, mediated by CYP1A1, CYP2C6 and CYP2C11 activities, respectively.	ethyl acetate	35-48	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	190-196
19577456-3	2010	In rat liver microsomes study, the ethyl acetate extract of Danshen, tanshinone I, tanshinone IIA and cryptotanshinone decreased the formation of 4"-, 6- and 7-hydroxy-warfarin, mediated by CYP1A1, CYP2C6 and CYP2C11 activities, respectively.	ethyl acetate	35-48	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	198-204
19577456-3	2010	In rat liver microsomes study, the ethyl acetate extract of Danshen, tanshinone I, tanshinone IIA and cryptotanshinone decreased the formation of 4"-, 6- and 7-hydroxy-warfarin, mediated by CYP1A1, CYP2C6 and CYP2C11 activities, respectively.	ethyl acetate	35-48	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	209-216
20566451-8	2010	None of the fractions reduced glucose concentration in the normoglycaemic rats, while only ethyl acetate fraction lowered glucose concentration significantly at 2 and 4 hours (49.7 and 39.0%) compared to control value of 74.9 and 69.7%, respectively, in the diabetic rats.	ethyl acetate	91-104	angiotensin II receptor, type 2	Rattus norvegicus	158-162
21808551-4	2010	The objective of the present study was to evaluate the effect of ethyl acetate extract from G. asiatica roots (EGAR) on estrogen receptor-positive (MCF-7) and negative (MDA-MB-231) human breast cancer cell lines.	ethyl acetate	65-78	estrogen receptor 1	Homo sapiens	120-137
20102206-7	2010	In addition, the ATE-EtOAc subfractions suppressed interleukin (IL)-4, IL-6, and tumor necrosis factor-alpha secretion in RBL-2H3 cells, indicating that adlay testa were able to inhibit cytokine secretion.	ethyl acetate	21-26	interleukin 6	Rattus norvegicus	71-108
20043140-1	2010	The active fraction of the extract of Asiasari radix, the 60% methanol chromatographic fraction from the ethyl acetate layer (PPAR), was used to investigate the melanogenesis signal pathway in B16F10 melanoma cells.	ethyl acetate	105-118	peroxisome proliferator activated receptor alpha	Mus musculus	126-130
19824901-6	2009	The structure and molecular mass of metabolites produced from dibenzothiophene desulphurization were identified by GC-MS, and two sulphur-free products, 2-HBP and biphenyl, were detected in ethyl acetate extract.	ethyl acetate	190-203	heme binding protein 1	Homo sapiens	155-158
20140805-2	2010	In the present study, bioactivity-guided fractionation of the ethyl acetate fraction of the methanol leaf extract of the plant material led to the isolation of a new flavonol glycoside (AFF1).	ethyl acetate	62-75	AF4/FMR2 family, member 1	Rattus norvegicus	186-190
20645828-5	2010	(Euphorbiaceae) leaves to inhibit human neutrophil elastase (HNE) and superoxide anion (O(2)(*-)) activities was evaluated on aqueous and ethyl acetate extracts as they allow for a targeted extraction of polyphenols.	ethyl acetate	138-151	elastase, neutrophil expressed	Homo sapiens	40-59
19764225-4	2009	Among the three fractions, the ethyl acetate fraction showed the highest RAR agonistic activities.	ethyl acetate	31-44	retinoic acid receptor alpha	Homo sapiens	73-76
19768977-4	2009	The ethyl acetate fraction from the ethanolic extract of Elephantopus scaber showed the highest effect with IC50 values of less than 25 microg/mL on three susceptible cell lines, namely, PC-3 (human prostate carcinoma cell), CNE (human nasopharyngeal carcinoma epithelial cell) and HL-60 (human acute promyelocytic leukemia cell).	ethyl acetate	4-17	chromobox 8	Homo sapiens	187-191
19469902-2	2009	The active 80% methanol chromatographic fraction from the ethyl acetate layer [partial purification from C. longa (PPC)] was used to investigate the alpha-melanocyte-stimulating hormone (alpha-MSH)-stimulated melanogenesis signal pathway in B16F10 cells.	ethyl acetate	58-71	pro-opiomelanocortin-alpha	Mus musculus	187-196
19641888-3	2009	The ethyl acetate-soluble fraction of the methanolic extract from the seeds was found to induce QR and the concentration of 1.5 fold QR induction (1.5 FIC) was 1.2 mug/mL.	ethyl acetate	4-17	crystallin, zeta	Mus musculus	96-98
19641888-3	2009	The ethyl acetate-soluble fraction of the methanolic extract from the seeds was found to induce QR and the concentration of 1.5 fold QR induction (1.5 FIC) was 1.2 mug/mL.	ethyl acetate	4-17	crystallin, zeta	Mus musculus	133-135
19269438-14	2009	It was shown in the present contribution, that the qualitative identification of nine test gas samples (vapors of ethanol, acetic acid and ethyl acetate in air) with our method was very accurate and fast.	ethyl acetate	139-152	gastrin	Homo sapiens	91-94
19429374-3	2009	AIM OF THE STUDY: To investigate the insulin sensitizing activity and antidiabetic effects of the ethyl acetate fraction of AC (ACE).	ethyl acetate	98-111	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	128-131
19155154-3	2009	The two COX-2 inhibitors were extracted from serum and synovial fluid following dilution with acetate buffer (pH 5) and liquid-liquid extraction (LLE) into ethyl acetate.	ethyl acetate	156-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
18713617-3	2008	Ethyl acetate extraction was also found to reduce interference by sodium dodecyl sulfate, Nonidet P-40, or Triton X-100 in the mass spectrometry analysis.	ethyl acetate	0-13	interleukin 9	Homo sapiens	98-102
19252318-4	2009	The ethyl acetate- and 1-butanol-soluble fractions also showed inhibitory effects on rat lens aldose reductase and scavenging effects on 1,1-diphenylpicryl-2-hydrazyl radical and superoxide.	ethyl acetate	4-17	aldo-keto reductase family 1 member B1	Rattus norvegicus	94-110
19213858-0	2009	The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice.	ethyl acetate	4-17	Fas (TNF receptor superfamily member 6)	Mus musculus	97-100
19213858-0	2009	The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice.	ethyl acetate	4-17	Fas (TNF receptor superfamily member 6)	Mus musculus	101-104
19111919-10	2009	RESULTS: We found that ethyl acetate fractions of AP, AS and MA significantly decreased NF-kappaB luciferase activity and also the secretion of NO and PGE(2) in LPS/IFN-gamma stimulated mouse peritoneal macrophages (p&lt;0.05).	ethyl acetate	23-36	interferon gamma	Mus musculus	165-174
19212101-6	2009	The ethyl acetate and butanol extracts of the stem bark of Peltophorum africanum showed inhibitory activity against HIV-1, CXCR4 (X4) and CCR5 (R5) tropic viruses.	ethyl acetate	4-17	C-C motif chemokine receptor 5	Homo sapiens	138-142
18721875-6	2008	Non-aqueous precipitation of lysozyme from solutions in DMSO with ethyl acetate led to a reversible aggregation without loss in biological activity.	ethyl acetate	66-79	lysozyme	Homo sapiens	29-37
18670102-3	2008	Butein and sulfuretin isolated from ethyl acetate fraction were found to possess strongly both forms of aldose reductase and advanced glycation endproducts inhibition.	ethyl acetate	36-49	aldo-keto reductase family 1 member B	Homo sapiens	104-120
18809484-9	2008	Furthermore, ethyl acetate extract inhibited both COX and 5-LOX with a marked decline in the production of 12-HHT (IC(50) 0.08+/-0.002microg/ml) and LTB(4) (IC(50) 0.86+/-0.03microg/ml), respectively.	ethyl acetate	13-26	lysyl oxidase	Rattus norvegicus	60-63
18666761-3	2008	For the compound with n = 4 (DBA4), analysis of dipole signals indicates that the effective charge separation distances in toluene, 1,4-dioxane, ethyl acetate, tetrahydrofuran, dichloromethane, 1,2-dichloroethane, 2-methylpentanone-3, 3-pentanone, and benzonitrile are 2.2, 2.5, 4.5, 4.7, 5.5, 5.5, 4.8, and 6.3 A, respectively.	ethyl acetate	145-158	ribosomal protein S17	Homo sapiens	29-33
18671198-1	2008	A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of MYRISTICA CRASSA.	ethyl acetate	76-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
18534796-12	2008	5-LOX IC(50) values were 25 microg/ml for EtOAc, 68 microg/ml for bacosides and 2 microg/ml for nordihydroguaiaretic acid (NDGA) where as COX-2 IC(50) values were 1.32 microg/ml for EtOAc, 1.19 microg/ml for bacoside fraction and 0.23 microg/ml for indomethacin.	ethyl acetate	42-47	lysyl oxidase	Rattus norvegicus	2-5
18534796-13	2008	EtOAc and bacoside fractions also brought about significant decrease in TNF-alpha release ex vivo.	ethyl acetate	0-5	tumor necrosis factor	Rattus norvegicus	72-81
18499458-5	2008	Gprk2 overexpression in OSNs from wild-type or cyc(01) flies elicits constant high-amplitude electroantennogram (EAG) responses to ethyl acetate, whereas Gprk2 mutants produce constant low-amplitude EAG responses.	ethyl acetate	131-144	G protein-coupled receptor kinase 2	Drosophila melanogaster	0-5
18826151-8	2008	The ethyl acetate part could reduce significantly the expression of Flk-1 protein and mRNA of HUVEC induced by VEGF.	ethyl acetate	4-17	vascular endothelial growth factor A	Homo sapiens	111-115
19112906-4	2008	The extraction eluted by 30% alcohol after purification with macroporous adsorption resin and extracted by EtOAc in the extraction of Sambucus chinensis by 75% alcohol all showed significantly protective effects on mice acute hepatic injury induced by CCl4, and the effects of the extraction eluted by 30% alcohol after purification with macroporous adsoption resin were better than extraction with EtOAc.	ethyl acetate	107-112	chemokine (C-C motif) ligand 4	Mus musculus	252-256
17431821-3	2008	We demonstrated that ethanol and ethyl acetate extracts from C. comatus and G. lucidum, respectively, selectively inhibit dihydrotestosterone-induced LNCaP cell viability, suppress levels of secreted prostate-specific antigen in a dose-dependent manner, and cause a G1 phase arrest in LNCaP, but not in DU 145 and PC-3 cells.	ethyl acetate	33-46	kallikrein related peptidase 3	Homo sapiens	200-225
17624704-6	2007	The ethyl acetate (EA) soluble fraction was the most active fraction of FC that significantly abolished the LTB and G(M1) interaction.	ethyl acetate	4-17	lymphotoxin B	Mus musculus	108-111
18221452-2	2008	As revealed by ethyl acetate extraction and absorption spectrophotometry, uptake of Pc 4 into the two cell lines was linear with Pc 4 concentration and similar on a per cell basis but greater in Jurkat cells on a per mass basis.	ethyl acetate	15-28	proprotein convertase subtilisin/kexin type 4	Homo sapiens	84-88
17961194-4	2008	In vitro findings have shown that human CYP1A2 is inhibited by the ethyl acetate extract of danshen and danshen pharmaceutical product.	ethyl acetate	67-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	40-46
17705147-0	2008	Growth inhibitory effect of ethyl acetate-soluble fraction of Cynara cardunculus L. in leukemia cells involves cell cycle arrest, cytochrome c release and activation of caspases.	ethyl acetate	28-41	cytochrome c, somatic	Homo sapiens	130-142
17705147-0	2008	Growth inhibitory effect of ethyl acetate-soluble fraction of Cynara cardunculus L. in leukemia cells involves cell cycle arrest, cytochrome c release and activation of caspases.	ethyl acetate	28-41	caspase 9	Homo sapiens	169-177
18001032-1	2007	The ability of a noncommercial immobilized lipase from Staphylococcus xylosus (SXLi) to catalyze the transesterification of tyrosol and ethyl acetate was investigated.	ethyl acetate	136-149	YSIRK-type signal peptide-containing protein	Staphylococcus xylosus	43-49
18008307-2	2007	The nonionic species ethanol, glucose, ethyl acetate, and ethyl butyrate were made accessible for analysis by CE via charged products or by-products obtained in enzymatic conversions using hexokinase, glucose oxidase, alcohol dehydrogenase, and esterase.	ethyl acetate	39-52	hexokinase 1	Homo sapiens	189-199
18008307-2	2007	The nonionic species ethanol, glucose, ethyl acetate, and ethyl butyrate were made accessible for analysis by CE via charged products or by-products obtained in enzymatic conversions using hexokinase, glucose oxidase, alcohol dehydrogenase, and esterase.	ethyl acetate	39-52	aldo-keto reductase family 1 member A1	Homo sapiens	218-239
18167444-3	2007	A squalene synthase inhibitor was screened from Prunus mume fruit, and then purified via sequential processes of ethanol extraction, HP-20 column chromatography, ethyl acetate extraction, silica gel column chromatography, and crystallization.	ethyl acetate	162-175	farnesyl-diphosphate farnesyltransferase 1	Sus scrofa	2-19
18067784-6	2007	The petroleum ether fraction, ethyl acetate fraction and n-butanol fraction of ethanol extract could inhibit the production of TNF-alpha mRNA, COX-2 mRNA and NF-kappaB to some extent.	ethyl acetate	30-43	tumor necrosis factor	Mus musculus	127-136
18067784-6	2007	The petroleum ether fraction, ethyl acetate fraction and n-butanol fraction of ethanol extract could inhibit the production of TNF-alpha mRNA, COX-2 mRNA and NF-kappaB to some extent.	ethyl acetate	30-43	prostaglandin-endoperoxide synthase 2	Mus musculus	143-148
18067784-6	2007	The petroleum ether fraction, ethyl acetate fraction and n-butanol fraction of ethanol extract could inhibit the production of TNF-alpha mRNA, COX-2 mRNA and NF-kappaB to some extent.	ethyl acetate	30-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
17929908-6	2007	Relative to pure ethyl acetate, reaction free energy change (-DeltaG(r)) increases by a factor of approximately 5, approximately 4, and approximately 2 for P4C, P5C, and P6C, respectively, at 2.5 M LiClO(4) in this solvent.	ethyl acetate	17-30	pyrroline-5-carboxylate reductase 1	Homo sapiens	161-164
18161590-3	2007	Electrophysiological recordings from the adult antenna indicate that rdgB is required for normal response in the peripheral olfactory system: some rdgB mutants show a delayed return to the resting potential following stimulation with ethyl acetate vapor.	ethyl acetate	234-247	retinal degeneration B	Drosophila melanogaster	69-73
18161590-3	2007	Electrophysiological recordings from the adult antenna indicate that rdgB is required for normal response in the peripheral olfactory system: some rdgB mutants show a delayed return to the resting potential following stimulation with ethyl acetate vapor.	ethyl acetate	234-247	retinal degeneration B	Drosophila melanogaster	147-151
17624704-6	2007	The ethyl acetate (EA) soluble fraction was the most active fraction of FC that significantly abolished the LTB and G(M1) interaction.	ethyl acetate	19-21	lymphotoxin B	Mus musculus	108-111
17643561-6	2007	Exposure to ethyl acetate further decreased immunogenicity of ova-LHRH.	ethyl acetate	12-25	gonadotropin releasing hormone 1	Rattus norvegicus	66-70
17516063-8	2007	N. crassa ADH1 possessed 5.3 mU/mg of specific carboxylate ester-forming activity accumulating 0.4 mM of ethyl acetate in 18 h. Substrate specificity of various linear alcohols and aldehydes indicated that short chain-length alcohols and aldehydes were good substrates for carboxylate ester production.	ethyl acetate	105-118	alcohol dehydrogenase I	Neurospora crassa OR74A	10-14
18074833-5	2007	CONCLUSION: The anticoagulant effect of ethyl acetate extract portion of LEEs is the strongest among the four portions, and this results may be from its inhibitory effect on thrombin-catalyzed fibrinogen hydrolysis.	ethyl acetate	40-53	coagulation factor II, thrombin	Homo sapiens	174-182
17715896-6	2007	The increases of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 expression in the aorta of aging rats were also significantly suppressed by SunAmla extract or EtOAc extract of amla, respectively.	ethyl acetate	178-183	nitric oxide synthase 2	Rattus norvegicus	17-48
17715896-6	2007	The increases of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 expression in the aorta of aging rats were also significantly suppressed by SunAmla extract or EtOAc extract of amla, respectively.	ethyl acetate	178-183	nitric oxide synthase 2	Rattus norvegicus	50-54
17715896-6	2007	The increases of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 expression in the aorta of aging rats were also significantly suppressed by SunAmla extract or EtOAc extract of amla, respectively.	ethyl acetate	178-183	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	60-82
17715896-10	2007	However, SunAmla or EtOAc extract of amla reduced the iNOS and COX-2 expression levels by inhibiting NF-kappaB activation in the aged rats.	ethyl acetate	20-25	nitric oxide synthase 2	Rattus norvegicus	54-58
17316946-1	2007	In this study, we first report the anti-invasive effect of ethylacetate extract from Antrodia cinnamomea (EAC) fruiting bodies in the human liver cancer cell line PLC/PRF/5.	ethyl acetate	59-71	CYLD lysine 63 deubiquitinase	Homo sapiens	106-109
17316946-1	2007	In this study, we first report the anti-invasive effect of ethylacetate extract from Antrodia cinnamomea (EAC) fruiting bodies in the human liver cancer cell line PLC/PRF/5.	ethyl acetate	59-71	heparan sulfate proteoglycan 2	Homo sapiens	163-166
17567069-1	2007	Bioactivity-guided fractionation of the ethyl acetate-soluble fraction of a methanol extract of the fruits of Casearia grewiifolia afforded eight new clerodane diterpenes, caseargrewiins E-L (1-8), and a known clerodane diterpene, esculentin B (9).	ethyl acetate	40-53	erythrocyte membrane protein band 4.1	Homo sapiens	187-195
17651057-2	2007	In the in vitro test (SRB assay), hexane and ethyl acetate fractions showed higher inhibition effects against MCF-7 cells than other samples at the 1 mg/mL level: 89% and 93.2%, respectively.	ethyl acetate	45-58	chaperonin containing TCP1 subunit 4	Homo sapiens	22-25
17081715-4	2007	During 24-72 h of incubation with a low (2x10(4) HSF cells/mL) density of cells, significant cytotoxicity was observed for methanol and ethyl acetate extracts at concentrations greater than 125 microg/mL.	ethyl acetate	136-149	interleukin 6	Homo sapiens	49-52
17507320-1	2007	Hepatoprotective activity of the ethyl acetate extract of Teucrium polium L. was investigated using rats with CCl4-induced liver damage.	ethyl acetate	33-46	C-C motif chemokine ligand 4	Rattus norvegicus	110-114
17085029-2	2007	The ethyl acetate extract showed strong activity in decreasing the secretion of prostate specific antigen (PSA) in LNCaP cells as compared to two other extracts, measured by ELISA with finasteride as positive control in the assay.	ethyl acetate	4-17	kallikrein related peptidase 3	Homo sapiens	80-105
17085029-2	2007	The ethyl acetate extract showed strong activity in decreasing the secretion of prostate specific antigen (PSA) in LNCaP cells as compared to two other extracts, measured by ELISA with finasteride as positive control in the assay.	ethyl acetate	4-17	kallikrein related peptidase 3	Homo sapiens	107-110
17517504-1	2007	Bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina addisoniae (Leguminosae), using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new (1-3) and three known (4-6) 2-arylbenzofuran derivatives.	ethyl acetate	36-41	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	132-137
16845703-5	2006	The overexpression of ATF1 significantly increased the concentrations of ethyl acetate, isoamyl acetate, 2-phenylethyl acetate and ethyl caproate, while the overexpression of ATF2 affected the concentrations of ethyl acetate and isoamyl acetate to a lesser degree.	ethyl acetate	73-86	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	22-26
17265559-2	2007	The first two extracts, SA1 and SA2, isolated at room temperature by ethyl acetate and water extraction, respectively, neutralized the enterovirus 71-induced cytopathic effect in Vero, rhabdomyosarcoma and MRC-5 cells.	ethyl acetate	69-82	stromal antigen 2	Homo sapiens	32-35
16880675-1	2006	Ethyl acetate extract of Pholidota chinensis L. showed strong NO production inhibitory activity in murine macrophage-like cell line, RAW 264.7, which was activated by a lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma).	ethyl acetate	0-13	interferon gamma	Mus musculus	198-214
16880675-1	2006	Ethyl acetate extract of Pholidota chinensis L. showed strong NO production inhibitory activity in murine macrophage-like cell line, RAW 264.7, which was activated by a lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma).	ethyl acetate	0-13	interferon gamma	Mus musculus	216-225
16845703-2	2006	The ATF1- and ATF2-encoded alcohol acetyltransferases of S. cerevisiae are responsible for the synthesis of ethyl acetate and isoamyl acetate esters, while the EHT1-encoded ethanol hexanoyl transferase is responsible for synthesizing ethyl caproate.	ethyl acetate	108-121	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	4-8
16845703-2	2006	The ATF1- and ATF2-encoded alcohol acetyltransferases of S. cerevisiae are responsible for the synthesis of ethyl acetate and isoamyl acetate esters, while the EHT1-encoded ethanol hexanoyl transferase is responsible for synthesizing ethyl caproate.	ethyl acetate	108-121	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	14-18
16845703-2	2006	The ATF1- and ATF2-encoded alcohol acetyltransferases of S. cerevisiae are responsible for the synthesis of ethyl acetate and isoamyl acetate esters, while the EHT1-encoded ethanol hexanoyl transferase is responsible for synthesizing ethyl caproate.	ethyl acetate	108-121	medium-chain fatty acid ethyl ester synthase/esterase	Saccharomyces cerevisiae S288C	160-164
16793048-5	2007	In this study, we determined the ability of human plasma and PON 1-rich HDL to hydrolyze acetyl ester of salicylic acid (aspirin).	ethyl acetate	89-101	paraoxonase 1	Homo sapiens	61-66
17203183-0	2007	Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio.	ethyl acetate	0-13	BCL2 associated X, apoptosis regulator	Homo sapiens	191-194
17203183-0	2007	Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio.	ethyl acetate	0-13	BCL2 apoptosis regulator	Homo sapiens	195-200
17696592-6	2007	Acetyl-L-carnitine (ALC), the acetyl ester of L-carnitine, plays an essential role in intermediary metabolism.	ethyl acetate	30-42	allantoicase	Homo sapiens	20-23
16828993-2	2006	Benzocaine, salicylic acid and acetanilide show a single peak in the least polar mixture (ethanol-ethyl acetate) at delta1=22.59, 21.70 and 20.91 MPa1/2, respectively.	ethyl acetate	98-111	guanylate binding protein 4	Homo sapiens	146-152
16828993-11	2006	The drugs with delta2 values above 25 MPa1/2 show two maxima, one in each solvent mixture (ethanol-water and ethanol-ethyl acetate).	ethyl acetate	117-130	guanylate binding protein 4	Homo sapiens	38-44
16845703-5	2006	The overexpression of ATF1 significantly increased the concentrations of ethyl acetate, isoamyl acetate, 2-phenylethyl acetate and ethyl caproate, while the overexpression of ATF2 affected the concentrations of ethyl acetate and isoamyl acetate to a lesser degree.	ethyl acetate	113-126	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	22-26
16845703-6	2006	The overexpression of IAH1 resulted in a significant decrease in ethyl acetate, isoamyl acetate, hexyl acetate and 2-phenylethyl acetate.	ethyl acetate	65-78	isoamyl acetate-hydrolyzing esterase	Saccharomyces cerevisiae S288C	22-26
16749787-5	2006	The tetrameric macrocycle exhibited a tub-shaped conformation and encapsulated a molecule of ethyl acetate inside the tub.	ethyl acetate	93-106	TUB bipartite transcription factor	Homo sapiens	38-41
21783687-13	2006	The pretreatment with ethyl acetate and ethanol extract reduced the GST activity by 76% and 30%, respectively.	ethyl acetate	22-35	hematopoietic prostaglandin D synthase	Rattus norvegicus	68-71
16749787-5	2006	The tetrameric macrocycle exhibited a tub-shaped conformation and encapsulated a molecule of ethyl acetate inside the tub.	ethyl acetate	93-106	TUB bipartite transcription factor	Homo sapiens	118-121
16521109-14	2006	In contrast, a selective PKA inhibitor, 50 microm Rp-8-Br-cAMP, blocked the development of EtOAc fraction-stimulated DA release.	ethyl acetate	91-96	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	25-28
17039882-0	2006	[Effect of the ethyl acetate extract of zhi ju zi on serum makers and the expression of TGF-beta1 in rats with hepatic fibrosis].	ethyl acetate	15-28	transforming growth factor, beta 1	Rattus norvegicus	88-97
16207520-10	2006	Here we investigated the effect of sativan isolated from the ethylacetate fractions of Viola verecunda on the expression of MMPs in UV-irradiated human skin fibroblasts in vitro.	ethyl acetate	61-73	matrix metallopeptidase 1	Homo sapiens	124-128
16637693-6	2006	In parallel with the activity of LOX, C6 compound [hexanal, hex-1-enol, (E)-hex-2-enal] concentrations reached a peak at 11.7% of weight loss, whereas ethanol and acetaldehyde increased with the increase of ADH and successively decrease and ethyl acetate increased.	ethyl acetate	241-254	lipoxygenase	Vitis vinifera	33-36
16361073-0	2006	Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-X(L) expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation.	ethyl acetate	0-13	BCL2 apoptosis regulator	Homo sapiens	78-83
16361073-0	2006	Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-X(L) expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation.	ethyl acetate	0-13	BCL2 like 1	Homo sapiens	84-92
16361073-0	2006	Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-X(L) expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation.	ethyl acetate	0-13	caspase 9	Homo sapiens	180-189
16597370-7	2006	Immunoblot analysis of microsomal proteins showed that ethyl acetate extract-treatment elevated the protein levels of CYP1A and CYP3A.	ethyl acetate	55-68	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	128-133
16597370-9	2006	At the dose corresponding to its content in ethyl acetate extract, tanshinone IIA-treatment increased mouse liver microsomal MROD activity.	ethyl acetate	44-57	ATPase, class II, type 9A	Mus musculus	78-81
16597370-10	2006	These results demonstrated that there were mouse CYP1A, CYP2C and CYP3A-inducing agents present in the ethyl acetate extract, but not in the aqueous extract, of S. miltiorrhiza.	ethyl acetate	103-116	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	66-71
16393471-11	2006	In addition, chloroform and ethyl acetate fractions significantly blocked the expression of inducible nitric oxide synthetase (iNOS) and interleukin-6 (IL-6) from the RAW264.7 cells stimulated by LPS.	ethyl acetate	28-41	interleukin 6	Mus musculus	137-150
16463070-6	2006	Six out of the eight studied Gal-4/UAS-IP3K1 hybrids displayed abnormal behavioral responses to ethyl acetate, acetone, ethanol or propionaldehyde.	ethyl acetate	96-109	Inositol 1,4,5-triphosphate kinase 1	Drosophila melanogaster	39-44
16125889-2	2005	Water extracts, a 70% methanol (MeOH) extract and an ethyl acetate (EtOAc) soluble fraction (III) from DJW inhibited platelet-activating factor (PAF)-induced platelet aggregation in vitro and in vivo assays.	ethyl acetate	53-66	PCNA clamp associated factor	Homo sapiens	145-148
16125889-2	2005	Water extracts, a 70% methanol (MeOH) extract and an ethyl acetate (EtOAc) soluble fraction (III) from DJW inhibited platelet-activating factor (PAF)-induced platelet aggregation in vitro and in vivo assays.	ethyl acetate	68-73	PCNA clamp associated factor	Homo sapiens	145-148
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	ethyl acetate	162-175	interleukin 1 beta	Mus musculus	224-247
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	ethyl acetate	162-175	interleukin 6	Mus musculus	249-253
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	ethyl acetate	162-175	tumor necrosis factor	Mus musculus	262-295
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	ethyl acetate	177-182	interleukin 1 beta	Mus musculus	224-247
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	ethyl acetate	177-182	interleukin 6	Mus musculus	249-253
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	ethyl acetate	177-182	tumor necrosis factor	Mus musculus	262-295
16638658-0	2005	Ethyl acetate extract from black tea prevents neuromuscular blockade by botulinum neurotoxin type A in vitro.	ethyl acetate	0-13	neurotoxin	Clostridium botulinum	82-92
16638658-9	2005	These results indicate that ethyl acetate extract from black tea is the best source for searching for tea-derived inactivating substance(s) of botulinum neurotoxin.	ethyl acetate	28-41	neurotoxin	Clostridium botulinum	153-163
16393471-11	2006	In addition, chloroform and ethyl acetate fractions significantly blocked the expression of inducible nitric oxide synthetase (iNOS) and interleukin-6 (IL-6) from the RAW264.7 cells stimulated by LPS.	ethyl acetate	28-41	interleukin 6	Mus musculus	152-156
16393471-12	2006	Moreover, ethyl acetate fractions significantly blocked the expression of IL-1beta from the RAW264.7 cells stimulated by LPS.	ethyl acetate	10-23	interleukin 1 beta	Mus musculus	74-82
16081098-2	2005	We present and analyze crystal structures of hCE1 in complexes with the cholesterol-lowering drug mevastatin, the breast cancer drug tamoxifen, the fatty acyl ethyl ester (FAEE) analogue ethyl acetate, and the novel hCE1 inhibitor benzil.	ethyl acetate	187-200	carboxylesterase 1	Homo sapiens	45-49
16205001-1	2005	In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7.	ethyl acetate	91-104	interferon gamma	Mus musculus	252-268
16205001-1	2005	In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7.	ethyl acetate	91-104	interferon gamma	Mus musculus	270-279
15624126-7	2005	Structures of the PF6- and NO3- complexes of 10 a were also solved as were those of the acetone adduct of 9 a and the ethyl acetate adduct of 11 a.	ethyl acetate	118-131	sperm associated antigen 17	Homo sapiens	18-30
16141292-8	2005	We find that training up-regulates the number of glomeruli that become c-fos positive after stimulation with ethyl acetate.	ethyl acetate	109-122	FBJ osteosarcoma oncogene	Mus musculus	71-76
15997094-4	2005	Human neutrophil elastase activity was inhibited distinctively by ethanolic (60 to 96%) and ethyl acetate extracts (IC50 of approximately 2 microg dry weight/ml).	ethyl acetate	92-105	elastase, neutrophil expressed	Homo sapiens	6-25
15802790-1	2005	Platelet activating factor (PAF)-acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes the acetyl ester at the sn-2 position of PAF, and converts it to the inactive metabolite, lyso PAF.	ethyl acetate	91-103	phospholipase A2 group VII	Bos taurus	0-48
15802790-1	2005	Platelet activating factor (PAF)-acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes the acetyl ester at the sn-2 position of PAF, and converts it to the inactive metabolite, lyso PAF.	ethyl acetate	91-103	phospholipase A2 group VII	Bos taurus	50-56
15802790-1	2005	Platelet activating factor (PAF)-acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes the acetyl ester at the sn-2 position of PAF, and converts it to the inactive metabolite, lyso PAF.	ethyl acetate	91-103	PCNA-associated factor	Bos taurus	28-31
15802790-1	2005	Platelet activating factor (PAF)-acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes the acetyl ester at the sn-2 position of PAF, and converts it to the inactive metabolite, lyso PAF.	ethyl acetate	91-103	PCNA-associated factor	Bos taurus	50-53
16114494-1	2005	In the course of screening anti-dementia agents from natural products, two beta-secretase (BACE1) inhibitors were isolated from the ethyl acetate soluble fraction of Sanguisorbae Radix by the activity-guided purification using silica gel, Sephadex LH-20, and RP-HPLC.	ethyl acetate	132-145	beta-secretase 1	Homo sapiens	91-96
15797630-2	2005	The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5.	ethyl acetate	67-79	CYLD lysine 63 deubiquitinase	Homo sapiens	108-111
15797630-2	2005	The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5.	ethyl acetate	67-79	heparan sulfate proteoglycan 2	Homo sapiens	178-181
15649409-3	2005	Ethyl acetate chicory root extract produced a marked inhibition of prostaglandin E(2) (PGE(2)) production in human colon carcinoma HT29 cells treated with the pro-inflammatory agent TNF-alpha.	ethyl acetate	0-13	tumor necrosis factor	Homo sapiens	182-191
15789744-1	2005	The EtOAc extract of Youngia koidzumiana significantly inhibited the diacylglycerol acyltransferase (DGAT) from rat liver microsomes.	ethyl acetate	4-9	diacylglycerol O-acyltransferase 1	Rattus norvegicus	69-99
15789744-1	2005	The EtOAc extract of Youngia koidzumiana significantly inhibited the diacylglycerol acyltransferase (DGAT) from rat liver microsomes.	ethyl acetate	4-9	diacylglycerol O-acyltransferase 1	Rattus norvegicus	101-105
15582610-0	2004	A selective Sc(OTf)3-catalyzed trialkylsilyl ether to acetyl ester exchange reaction with beta-l-idopyranoside and 3,4-O-isopropylidene-beta-D-galactopyranoside derivatives.	ethyl acetate	54-66	POU class 5 homeobox 1	Homo sapiens	12-20
16019886-8	2005	While the primary emulsion was stirred without quenching, lysozyme in the inner water phase continued diffusing across the ethyl acetate phase into the aqueous continuous phase.	ethyl acetate	123-136	lysozyme	Homo sapiens	58-66
16019886-12	2005	As a result, the rate of ethyl acetate removal influenced lysozyme encapsulation efficiency, as well as microsphere size.	ethyl acetate	25-38	lysozyme	Homo sapiens	58-66
16019886-13	2005	Depending on the timing of ethyl acetate quenching, lysozyme encapsulation efficiencies were found to be 9.89 +/- 4.53 approximately 75.82 +/- 6.55%.	ethyl acetate	27-40	lysozyme	Homo sapiens	52-60
15635251-1	2005	In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7.	ethyl acetate	91-104	interferon gamma	Mus musculus	252-268
15635251-1	2005	In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7.	ethyl acetate	91-104	interferon gamma	Mus musculus	270-279
14631118-8	2003	The bitter gourd EA extract was then incorporated into the medium for treatment of a peroxisome proliferator-responsive murine hepatoma cell line, H4IIEC3, for 72 h. Treated cells showed significantly higher activity of acyl CoA oxidase and higher expressions of mRNA of this enzyme and fatty acid-binding protein, indicating that the bitter gourd EA extract was able to act on a natural PPARalpha signaling pathway in this cell line.	ethyl acetate	17-19	peroxisome proliferator-activated receptor alpha	Cricetulus griseus	388-397
14643306-1	2003	The EtOAc extract of licorice (Glycyrrhiza uralensis roots) exhibited considerable PPAR-gamma ligand-binding activity.	ethyl acetate	4-9	peroxisome proliferator activated receptor gamma	Mus musculus	83-93
14723335-1	2003	A prolyl endopeptidase inhibitor was isolated from the ethyl acetate soluble fraction of Phyllanthus ussurensis.	ethyl acetate	55-68	prolyl endopeptidase	Homo sapiens	2-22
15712877-4	2004	The experimental results demonstrate that when the mole ratio of ethyl acetate to silica was 0.82, the particle size of the superfine silica powder was in the range of 25-50 nm, the BET specific surface area was 420 m2/g, and the total pore volume was 0.68 cm3/g.	ethyl acetate	65-78	delta/notch like EGF repeat containing	Homo sapiens	182-185
12911335-5	2004	Comparison of the MS and MS/MS results (direct infusion) of an authentic sample of GA3 and the ethyl acetate extract from the broth revealed the formation of reduced GA3 in the broth.	ethyl acetate	95-108	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	166-169
14608046-3	2003	In this study, we showed that nonaqueous fractions of licorice (Glycyrrhiza uralensis Fisher) extracted with ethanol, ethyl acetate and acetone, but not an aqueous extract, had PPAR-gamma ligand-binding activity with a GAL4-PPAR-gamma chimera assay.	ethyl acetate	118-131	peroxisome proliferator activated receptor gamma	Mus musculus	177-187
14608046-3	2003	In this study, we showed that nonaqueous fractions of licorice (Glycyrrhiza uralensis Fisher) extracted with ethanol, ethyl acetate and acetone, but not an aqueous extract, had PPAR-gamma ligand-binding activity with a GAL4-PPAR-gamma chimera assay.	ethyl acetate	118-131	peroxisome proliferator activated receptor gamma	Mus musculus	224-234
12916071-6	2003	Ethyl acetate extract from Polygonum amphibium caused the rise in the number of CD25 and HLA-DR positive lymphocytes and increased the expression of CD25 and CD71 antigens.	ethyl acetate	0-13	interleukin 2 receptor, alpha chain	Mus musculus	80-84
14592472-1	2003	In the course of searching for BACE1 (beta-secretase) inhibitors from natural products, the ethyl acetate soluble fraction of green tea, which was suspected to be rich in catechin content, showed potent inhibitory activity.	ethyl acetate	92-105	beta-secretase 1	Homo sapiens	31-36
12957907-5	2003	Analysis of the fermentation products confirmed that the expression levels of ATF1 and ATF2 greatly affect the production of ethyl acetate and isoamyl acetate.	ethyl acetate	125-138	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	78-82
12957907-5	2003	Analysis of the fermentation products confirmed that the expression levels of ATF1 and ATF2 greatly affect the production of ethyl acetate and isoamyl acetate.	ethyl acetate	125-138	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	87-91
12916071-6	2003	Ethyl acetate extract from Polygonum amphibium caused the rise in the number of CD25 and HLA-DR positive lymphocytes and increased the expression of CD25 and CD71 antigens.	ethyl acetate	0-13	interleukin 2 receptor, alpha chain	Mus musculus	149-153
12916071-6	2003	Ethyl acetate extract from Polygonum amphibium caused the rise in the number of CD25 and HLA-DR positive lymphocytes and increased the expression of CD25 and CD71 antigens.	ethyl acetate	0-13	transferrin receptor	Mus musculus	158-162
12943230-4	2003	The inhibitory activity was retained in the ethyl acetate-soluble fraction (50-95% inhibition at 10-50 microg/ml) which also reduced the release of MMP-9 by mouse peritoneal macrophages up to 80%.	ethyl acetate	44-57	matrix metallopeptidase 9	Mus musculus	148-153
12547653-1	2003	The platelet-activating factor-acetylhydrolase (PAF-AH) is an enzyme which catalyzes the hydrolysis of acetyl ester at the sn-2 position of PAF.	ethyl acetate	103-115	phospholipase A2 group VII	Homo sapiens	4-46
12547653-1	2003	The platelet-activating factor-acetylhydrolase (PAF-AH) is an enzyme which catalyzes the hydrolysis of acetyl ester at the sn-2 position of PAF.	ethyl acetate	103-115	phospholipase A2 group VII	Homo sapiens	48-54
12375975-1	2002	Lewis acid Mg(ClO4)2, combined with NBS, in CH3CN or EtOAc provided mild and fast bromination of 1,3-dicarbonyl compounds.	ethyl acetate	53-58	nibrin	Homo sapiens	36-39
12819385-7	2002	The ethylacetate fraction of BP (BPE) significantly suppressed the FCA-induced paw edema as well as the serum level of interleukin-6 and it alleviated the radiological changes.	ethyl acetate	4-16	interleukin 6	Rattus norvegicus	119-132
12020927-4	2002	The ACE activities were inhibited significantly by the additions of ethylacetate and butanol extracts from Bulbus Fritillaria, of which IC(50) values were 292 and 320 microg/ml, respectively.	ethyl acetate	68-80	angiotensin I converting enzyme	Rattus norvegicus	4-7
12134950-1	2002	PURPOSE: The aim of this study is to investigate the effects of 50% ethyl acetate extracts of grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) in the rat small intestine.	ethyl acetate	68-81	phosphoglycolate phosphatase	Rattus norvegicus	184-188
11730347-2	2001	Four synthesized sEH inhibitors were extracted from rat hepatic microsomes with ethyl acetate and were determined by HPLC using positive ion electrospray tandem mass spectrometry within 7 min.	ethyl acetate	80-93	epoxide hydrolase 2	Rattus norvegicus	17-20
12033375-8	2002	Pretreatment with EtAc:EtOH (1:1) exhibited an insulin flux of 15.29 x 10(-8) nmoles/ cm2/h compared to 52.71 x 10(-8) nmoles/ cm2/h during passive and iontophoretic transport, respectively.	ethyl acetate	18-22	insulin	Homo sapiens	47-54
12033375-9	2002	The passive and iontophoretic flux of insulin through EtAc:EtOH (1:1) pretreated epidermis was significantly greater (P &lt; 0.05) than EtAc treated epidermis.	ethyl acetate	54-58	insulin	Homo sapiens	38-45
11000026-1	2000	An ethyl acetate-soluble extract of the combined leaves and twigs of Thuja occidentalis was found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) in cultured mouse epidermal ME 308 cells.	ethyl acetate	3-16	ornithine decarboxylase 1	Homo sapiens	160-183
11714371-4	2001	An ethyl acetate extract of green tea, containing 70% (w/w) catechins, also increased the LDL receptor binding activity, protein, and mRNA, indicating that (1) the effect was at the level of gene transcription and that (2) the catechins were the active constituents.	ethyl acetate	3-16	low density lipoprotein receptor	Homo sapiens	90-102
11642322-5	2001	The ethyl acetate layer was found to be associated with a distinct decrease in the NO level and inducible NO synthase.	ethyl acetate	4-17	nitric oxide synthase 2	Homo sapiens	96-117
11522328-8	2001	Progesterone selectively inhibited alpha(2) GlyRs, while PREG and its acetic ester potentiated alpha(1) GlyRs.	ethyl acetate	70-82	glycine receptor alpha 1	Homo sapiens	95-109
11428671-4	2001	The potentiating activity of NGF-action was observed in the ethyl acetate and n-butanol fractions.	ethyl acetate	60-73	nerve growth factor	Rattus norvegicus	29-32
10734174-3	2000	An ethyl acetate extract of orange juice did not affect the initial uptake rate of [(3)H]vinblastine but significantly increased the steady-state uptake, as did cyclosporin A (20 microM), an inhibitor of P-gp.	ethyl acetate	3-16	ATP binding cassette subfamily B member 1	Homo sapiens	204-208
10919373-3	2000	The NGF-potentiating activity was observed in the ethyl acetate fraction.	ethyl acetate	50-63	nerve growth factor	Rattus norvegicus	4-7
10919373-4	2000	The ethyl acetate solubles were fractionated by silica gel chromatography, monitoring the NGF-potentiating activity to give two iridoid glycosides, picrosides I and II.	ethyl acetate	4-17	nerve growth factor	Rattus norvegicus	90-93
10841499-1	2000	[equation--see text] The Rh(II)-catalyzed reaction of diazoacetic esters with various carbonyl compounds is an effective method for the synthesis of acetic ester ethers of the corresponding enol forms.	ethyl acetate	59-71	Rh blood group D antigen	Homo sapiens	25-30
10734174-10	2000	The ethyl acetate extract of orange juice and these methoxyflavones also increased steady-state [(3)H]vinblastine uptake by LLC-GA5-COL300 cells (a cell line transfected with human MDR1 cDNA).	ethyl acetate	4-17	ATP binding cassette subfamily B member 1	Homo sapiens	181-185
10576620-2	1999	We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.	ethyl acetate	141-154	tumor necrosis factor	Homo sapiens	228-237
10576620-2	1999	We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.	ethyl acetate	141-154	intercellular adhesion molecule 1	Homo sapiens	260-266
10576620-2	1999	We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.	ethyl acetate	141-154	vascular cell adhesion molecule 1	Homo sapiens	268-274
10576620-2	1999	We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.	ethyl acetate	141-154	selectin E	Homo sapiens	279-289
10362718-6	1999	Partial characterization of the released NCA and MCA showed that the activities were partially heat labile, trypsin digested, and predominantly ethyl acetate extractable.	ethyl acetate	144-157	CEA cell adhesion molecule 4	Homo sapiens	41-44
18967721-5	1999	A sequential extraction of a water sample with n-hexane and ethyl acetate is used to separate NS and other interferents as well as dichloromethane and chloroform for the separation of PEG into LC- and SC-fractions.	ethyl acetate	60-73	progestagen associated endometrial protein	Homo sapiens	184-187
9846980-7	1998	Partial characterization of NCA and MCA revealed that the activity was partly heat labile, trypsin sensitive, and ethyl acetate extractable.	ethyl acetate	114-127	CEA cell adhesion molecule 4	Homo sapiens	28-31
10229865-5	1999	Partial characterization revealed that NCA was partly heat labile, trypsin sensitive, and predominantly ethyl acetate extractable.	ethyl acetate	104-117	CEA cell adhesion molecule 4	Homo sapiens	39-42
9929608-2	1998	Three independent mutant alleles of eag revealed reduced antennal responsiveness in adult flies to a subset of odorants, all having short aliphatic side chains: ethyl butyrate (EB), propionic acid, 2-butanone and ethyl acetate (manuscript submitted).	ethyl acetate	213-226	ether a go-go	Drosophila melanogaster	36-39
9178939-2	1997	CYP3A-catalyzed 6beta-hydroxylation of testosterone in livers of rat and human was inhibited by the addition of an ethyl acetate-extract of grapefruit juice.	ethyl acetate	115-128	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	0-5
9748494-12	1998	Kinetic study of BuChE-catalysed hydrolysis of different acetyl esters showed that the rate limiting step was acetylation.	ethyl acetate	57-70	butyrylcholinesterase	Homo sapiens	17-22
9324931-4	1997	The lipophilic ethylacetate-soluble fraction A, enriched in flavone derivatives and constituting 14.9% of WS-1442, was as active as WS-1442 in inhibiting HNE.	ethyl acetate	15-27	elastase, neutrophil expressed	Homo sapiens	154-157
9671652-3	1998	Four independent mutant eag alleles exhibited reduced antennal sensitivity to a subset of nine odorants, all having short aliphatic side chains: ethyl butyrate (EB), propionic acid, 2-butanone, and ethyl acetate.	ethyl acetate	198-211	ether a go-go	Drosophila melanogaster	24-27
9439441-3	1997	The effluent with water was extracted with ethyl acetate two times (pH 1 and 3) and the organic acids were quantitatively converted into their trimethylsilyl derivatives for detection by gas chromatography-mass spectrometry.	ethyl acetate	43-56	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	68-78
9201608-3	1997	The results indicated that the CHCl3 fraction and EtOAc fractions exhibited the greatest hepatoprotective effects on CCl4-induced liver injuries, the CHCl3 fraction and n-hexane fraction are most potent against D-GalN-induced intoxication, and the CHCl3 fraction represented the most liver-protective effect on APAP-induced hepatotoxicity.	ethyl acetate	50-55	C-C motif chemokine ligand 4	Rattus norvegicus	117-121
9140137-6	1997	Rac-DMSA is more soluble than meso-DMSA in acetonitrile, ethyl acetate, and ethyl ether.	ethyl acetate	57-70	Rac family small GTPase 2	Rattus norvegicus	0-3
9090873-1	1997	As part of a search for novel biologically active compounds in the Macrophage Scavenger Receptor (MSR) assay, the EtOAc extract of a gorgonian coral, Pseudopterogorgia rigida, was shown to be active.	ethyl acetate	114-119	progestin and adipoQ receptor family member 7	Homo sapiens	98-101
9039149-6	1997	Large quantities of neutral 11 beta(HSD1)- and 11 beta(HSD2)-GALFs can be extracted directly from urine into ethyl acetate, yielding fraction EA1.	ethyl acetate	109-122	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	28-35
9039149-6	1997	Large quantities of neutral 11 beta(HSD1)- and 11 beta(HSD2)-GALFs can be extracted directly from urine into ethyl acetate, yielding fraction EA1.	ethyl acetate	109-122	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	47-54
9039149-6	1997	Large quantities of neutral 11 beta(HSD1)- and 11 beta(HSD2)-GALFs can be extracted directly from urine into ethyl acetate, yielding fraction EA1.	ethyl acetate	109-122	potassium voltage-gated channel subfamily A member 1	Homo sapiens	142-145
9039149-7	1997	Hydrolysis of the GALFs remaining in the aqueous phase by beta-glucuronidase markedly increases the total amounts of GALFs, with the majority now being ethyl acetate extractable (fraction EA2).	ethyl acetate	152-165	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	188-191