PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset
21385904-0 2011 MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. mir-218 0-7 slit guidance ligand 2 Homo sapiens 96-101
22088371-15 2011 Introducing exogenous miR-218 may effectively down-regulate the CDK6 expression, inhibit cell proliferation and induce apoptosis of malignant giloma cells. mir-218 22-29 cyclin dependent kinase 6 Homo sapiens 64-68
21385904-0 2011 MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. mir-218 0-7 roundabout guidance receptor 1 Homo sapiens 102-107
21385904-6 2011 Direct interaction between miR-218 and the 3"-untranslated regions (UTR) of mRNAs encoding ROBO1, survivin (BIRC5), and connexin43 (GJA1) was validated in a luciferase-based transcription reporter assay. mir-218 27-34 roundabout guidance receptor 1 Homo sapiens 91-96
21385904-6 2011 Direct interaction between miR-218 and the 3"-untranslated regions (UTR) of mRNAs encoding ROBO1, survivin (BIRC5), and connexin43 (GJA1) was validated in a luciferase-based transcription reporter assay. mir-218 27-34 baculoviral IAP repeat containing 5 Homo sapiens 108-113
21385904-6 2011 Direct interaction between miR-218 and the 3"-untranslated regions (UTR) of mRNAs encoding ROBO1, survivin (BIRC5), and connexin43 (GJA1) was validated in a luciferase-based transcription reporter assay. mir-218 27-34 gap junction protein alpha 1 Homo sapiens 120-130
21385904-6 2011 Direct interaction between miR-218 and the 3"-untranslated regions (UTR) of mRNAs encoding ROBO1, survivin (BIRC5), and connexin43 (GJA1) was validated in a luciferase-based transcription reporter assay. mir-218 27-34 gap junction protein alpha 1 Homo sapiens 132-136
20933503-0 2010 miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-beta. mir-218 0-7 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 82-90
20947829-6 2010 Using in vitro and in vivo approaches, we demonstrate that miR-218 directly represses the expression of Robo1, Robo2, and glucuronyl C5-epimerase (GLCE), and that an intact miR-218-Slit-Robo regulatory network is essential for normal vascularization of the retina. mir-218 59-66 roundabout guidance receptor 1 Homo sapiens 104-109
20947829-6 2010 Using in vitro and in vivo approaches, we demonstrate that miR-218 directly represses the expression of Robo1, Robo2, and glucuronyl C5-epimerase (GLCE), and that an intact miR-218-Slit-Robo regulatory network is essential for normal vascularization of the retina. mir-218 59-66 roundabout guidance receptor 2 Homo sapiens 111-116
20947829-6 2010 Using in vitro and in vivo approaches, we demonstrate that miR-218 directly represses the expression of Robo1, Robo2, and glucuronyl C5-epimerase (GLCE), and that an intact miR-218-Slit-Robo regulatory network is essential for normal vascularization of the retina. mir-218 59-66 glucuronic acid epimerase Homo sapiens 122-145
20947829-6 2010 Using in vitro and in vivo approaches, we demonstrate that miR-218 directly represses the expression of Robo1, Robo2, and glucuronyl C5-epimerase (GLCE), and that an intact miR-218-Slit-Robo regulatory network is essential for normal vascularization of the retina. mir-218 59-66 glucuronic acid epimerase Homo sapiens 147-151
20947829-6 2010 Using in vitro and in vivo approaches, we demonstrate that miR-218 directly represses the expression of Robo1, Robo2, and glucuronyl C5-epimerase (GLCE), and that an intact miR-218-Slit-Robo regulatory network is essential for normal vascularization of the retina. mir-218 59-66 roundabout guidance receptor 1 Homo sapiens 104-108
33887325-9 2021 The data on SOCS3 depletion in combination with miR-218 inhibition suggested that the antiviral activity of miR-218 required the SOCS3-mediated signaling pathway. mir-218 48-55 suppressor of cytokine signaling 3 Homo sapiens 129-134
20300657-0 2010 MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. mir-218 0-7 roundabout guidance receptor 1 Homo sapiens 76-81
34589277-10 2021 In vivo, intravitreal injection of miR-218 reduced retinal EC proliferation accompanied by MYC repression, attenuated pathological choroidal neovascularization, and rescued retinal EC hyper-sprouting induced by Notch blockade. mir-218 35-42 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-94
34589277-11 2021 In summary, miR-218 mediates the effect of Notch activation of EC quiescence via MYC and is a potential treatment for angiogenesis-related diseases. mir-218 12-19 MYC proto-oncogene, bHLH transcription factor Homo sapiens 81-84
34659498-9 2021 Moreover, suppression of spred2 abrogated the protective effects of miR-218 inhibition on H2O2-injured PC12 cells. mir-218 68-75 sprouty-related, EVH1 domain containing 2 Rattus norvegicus 25-31
34659498-10 2021 Depletion of miR-218 protected PC12 cells against H2O2-induced cell injury via the upregulation of spred2, which provided a promising therapeutic strategy for spinal cord injury. mir-218 13-20 sprouty-related, EVH1 domain containing 2 Rattus norvegicus 99-105
34515321-11 2021 Furthermore, miR-218 overexpression blocked the promoting effects of Rab6c on the malignant behavior of bladder cancer cells. mir-218 13-20 RAB6C, member RAS oncogene family Homo sapiens 69-74
35506187-0 2022 MiR-218 promotes oxidative stress and inflammatory response by inhibiting SPRED2-mediated autophagy in HG-induced HK-2 cells. mir-218 0-7 sprouty related EVH1 domain containing 2 Homo sapiens 74-80
33189795-7 2021 In conclusion, miR-218 partially accounts for the prevention effect during malignant transformation of normal esophageal epithelial cells, which targets GAB2, which supplies the potential treatment in cancer therapy. mir-218 15-22 GRB2 associated binding protein 2 Homo sapiens 153-157
33417267-0 2021 miR-218 contributes to drug resistance in multiple myeloma via targeting LRRC28. mir-218 0-7 leucine rich repeat containing 28 Homo sapiens 73-79
33335569-0 2021 miR-218 inhibits glucose metabolism in non-small cell lung cancer via the NF-kappaB signaling pathway. mir-218 0-7 nuclear factor kappa B subunit 1 Homo sapiens 74-83
33408470-0 2020 MiR-218 Inhibits CSE-Induced Apoptosis and Inflammation in BEAS-2B by Targeting BRD4. mir-218 0-7 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 17-20
33179084-11 2021 In conclusion, miR-218 could simultaneously suppress cell proliferation and tumor invasiveness and induce cell apoptosis by increasing PTEN and YY1 expression, while decreasing BCL-2 and BMI-1 in Xuanwei lung cancer. mir-218 15-22 BCL2 apoptosis regulator Homo sapiens 199-204
33408470-0 2020 MiR-218 Inhibits CSE-Induced Apoptosis and Inflammation in BEAS-2B by Targeting BRD4. mir-218 0-7 bromodomain containing 4 Homo sapiens 80-84
33408470-9 2020 Results: MiR-218 was downregulated in COPD and CSE-induced BEAS-2B cells, and it was positively correlated with forced expiratory volume in 1 second (FEV1) % in COPD patients. mir-218 9-16 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 47-50
33408470-12 2020 Conclusion: Overexpression of miR-218 inhibited CSE-induced apoptosis and inflammation in BEAS-2B cells by targeting BRD4 expression. mir-218 30-37 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 48-51
33408470-12 2020 Conclusion: Overexpression of miR-218 inhibited CSE-induced apoptosis and inflammation in BEAS-2B cells by targeting BRD4 expression. mir-218 30-37 bromodomain containing 4 Homo sapiens 117-121
32408786-8 2020 miR-218 reduced cell viability and induced apoptosis by negatively regulating DACH1. mir-218 0-7 dachshund family transcription factor 1 Homo sapiens 78-83
33303006-0 2020 MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1. mir-218 0-7 RUNX family transcription factor 2 Homo sapiens 116-121
33303006-0 2020 MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1. mir-218 0-7 myocyte enhancer factor 2C Homo sapiens 123-128
33303006-0 2020 MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1. mir-218 0-7 collagen type X alpha 1 chain Homo sapiens 134-141
33303006-17 2020 This could be explained by a concomitant activation of WNT/beta-catenin signaling counteracting the anti-hypertrophic effects of miR-218. mir-218 129-136 catenin beta 1 Homo sapiens 59-71
33425098-13 2020 The effect of miR-218 on glioma cells could be partially rescued by PDE7A. mir-218 14-21 phosphodiesterase 7A Homo sapiens 68-73
32239388-8 2020 Mechanistically, introduction of miR-218 reversed the inhibitory effects of CCAT1 on OGD/R-induced apoptosis and inflammation damage, which directly resulted from the inhibition of miR-218 and its targeting of NFAT5. mir-218 33-40 colon cancer associated transcript 1 Homo sapiens 76-81
32239388-8 2020 Mechanistically, introduction of miR-218 reversed the inhibitory effects of CCAT1 on OGD/R-induced apoptosis and inflammation damage, which directly resulted from the inhibition of miR-218 and its targeting of NFAT5. mir-218 33-40 nuclear factor of activated T cells 5 Homo sapiens 210-215
33051753-4 2020 In this study, we investigated whether miR-218 can significantly promote the osteogenic differentiation of mesenchymal stem cells in conditional media by regulating beta-catenin signaling inhibitors. mir-218 39-46 catenin beta 1 Homo sapiens 165-177
33455114-8 2020 Moreover, miR-218 was observed to directly regulate the HMGB1/RAGE signaling pathway in a targeted manner to affect the proliferation and migration of CC cells. mir-218 10-17 high mobility group box 1 Homo sapiens 56-61
33455114-8 2020 Moreover, miR-218 was observed to directly regulate the HMGB1/RAGE signaling pathway in a targeted manner to affect the proliferation and migration of CC cells. mir-218 10-17 advanced glycosylation end-product specific receptor Homo sapiens 62-66
33455114-9 2020 CONCLUSIONS: MiR-218 inhibits the HMGB1/RAGE pathway to suppress the proliferation, migration and invasion of CC cells. mir-218 13-20 high mobility group box 1 Homo sapiens 34-39
33455114-9 2020 CONCLUSIONS: MiR-218 inhibits the HMGB1/RAGE pathway to suppress the proliferation, migration and invasion of CC cells. mir-218 13-20 advanced glycosylation end-product specific receptor Homo sapiens 40-44
32552941-13 2020 Luciferase assay indicated that Bmi-1 could targeted on miR-218 directly. mir-218 56-63 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 32-37
32843060-4 2020 The interaction between SNHG10 and miR-218 was evaluated by overexpression experiment. mir-218 35-42 small nucleolar RNA host gene 10 Homo sapiens 24-30
32894525-0 2020 MiR-218 promotes apoptosis of U2OS osteosarcoma cells through targeting BIRC5. mir-218 0-7 baculoviral IAP repeat containing 5 Homo sapiens 72-77
32552941-14 2020 CONCLUSION: miR-218 can inhibit the proliferation, metastasis and invasion of APL cells, which can be related with the down-regulated of Bmi-1. mir-218 12-19 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 137-142
31114981-4 2019 The correlation between miR-218 and CCAT1 was detected by statistical analysis. mir-218 24-31 colon cancer associated transcript 1 Homo sapiens 36-41
32048632-9 2020 RESULTS MiR-218-5p level was notably increased in OGD/R injured PC12 cells and directly targeted NDRG4. mir-218 25-32 NDRG family member 4 Rattus norvegicus 114-119
31190333-0 2019 Downregulation of miR-218 by nicotine promotes cell proliferation through targeting CDK6 in non-small cell lung cancer. mir-218 18-25 cyclin dependent kinase 6 Homo sapiens 84-88
31190333-10 2019 Furthermore, miR-218- or nicotine-induced proliferative effects of NSCLC cells were rescued by the recovery of the expression level of CDK6. mir-218 13-20 cyclin dependent kinase 6 Homo sapiens 135-139
30444938-5 2019 Overexpression of miR-218 can suppress the degradation of Collagen Types I and IV and dentin sialoprotein (DSP), attenuate osteoclast formation, and inhibit the secretion of proinflammatory cytokines. mir-218 18-25 dentin sialophosphoprotein Rattus norvegicus 86-105
30444938-5 2019 Overexpression of miR-218 can suppress the degradation of Collagen Types I and IV and dentin sialoprotein (DSP), attenuate osteoclast formation, and inhibit the secretion of proinflammatory cytokines. mir-218 18-25 dentin sialophosphoprotein Rattus norvegicus 107-110
30444938-7 2019 Furthermore, the inhibitory effect of miR-218 was prevented by rescuing the Mmp9 expression. mir-218 38-45 matrix metallopeptidase 9 Rattus norvegicus 76-80
30867751-3 2019 The present study examined the effects of miR-218 on CIP2A expression in ccRCC cells. mir-218 42-49 cellular inhibitor of PP2A Homo sapiens 53-58
30840261-0 2019 MiR-218 suppresses metastasis and invasion of endometrial cancer via negatively regulating ADD2. mir-218 0-7 adducin 2 Homo sapiens 91-95
30840261-13 2019 CONCLUSIONS: In the present study, we elucidated that miR-218 served as a tumor suppressor in EC by negatively regulating ADD2. mir-218 54-61 adducin 2 Homo sapiens 122-126
29845219-9 2018 Collectively, the present study demonstrated that miR-218 induced the apoptosis of SW1417 cells by targeting c-FLIP. mir-218 50-57 CASP8 and FADD like apoptosis regulator Homo sapiens 109-115
30420101-0 2019 miR-218 inhibits gastric tumorigenesis through regulating Bmi-1/Akt signaling pathway. mir-218 0-7 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 58-63
30420101-0 2019 miR-218 inhibits gastric tumorigenesis through regulating Bmi-1/Akt signaling pathway. mir-218 0-7 AKT serine/threonine kinase 1 Homo sapiens 64-67
30646874-6 2019 The transfection of miR-218 mimics notably enhanced SDSCs chondrocytes differentiation, as evidenced by augmented expressions of chondrogenic markers (SOX9, COL2A1, ACAN, GAG, and COMP) in terms of mRNA and protein level, and the inhibition of miR-218 yielded opposite resutls. mir-218 20-27 LOW QUALITY PROTEIN: transcription factor SOX-9 Oryctolagus cuniculus 151-155
30646874-6 2019 The transfection of miR-218 mimics notably enhanced SDSCs chondrocytes differentiation, as evidenced by augmented expressions of chondrogenic markers (SOX9, COL2A1, ACAN, GAG, and COMP) in terms of mRNA and protein level, and the inhibition of miR-218 yielded opposite resutls. mir-218 20-27 collagen alpha-1(II) chain Oryctolagus cuniculus 157-163
30646874-6 2019 The transfection of miR-218 mimics notably enhanced SDSCs chondrocytes differentiation, as evidenced by augmented expressions of chondrogenic markers (SOX9, COL2A1, ACAN, GAG, and COMP) in terms of mRNA and protein level, and the inhibition of miR-218 yielded opposite resutls. mir-218 20-27 aggrecan core protein Oryctolagus cuniculus 165-169
30402837-0 2018 MiR-218 promotes apoptosis of U2OS osteosarcoma cells through targeting BIRC5. mir-218 0-7 baculoviral IAP repeat containing 5 Homo sapiens 72-77
30402837-11 2018 The elevation of miR-218 and/or silencing BIRC5 significantly depressed BRIC5-induced inhibition on caspase-5, and facilitated U2OS cell apoptosis (p<0.05). mir-218 17-24 caspase 5 Homo sapiens 100-109
30402837-12 2018 CONCLUSIONS: We observed that miR-218 was significantly down-regulated in osteosarcoma tissues, which had elevated BIRC5 expression. mir-218 30-37 baculoviral IAP repeat containing 5 Homo sapiens 115-120
30314496-8 2018 IDO1 is a direct target of miR-218. mir-218 27-34 indoleamine 2,3-dioxygenase 1 Homo sapiens 0-4
30319270-9 2018 miR-218 overexpression inactivated the PTEN/PI3K/AKT pathway, which was abated by Runx2 upregulation. mir-218 0-7 phosphatase and tensin homolog Homo sapiens 39-43
30319270-9 2018 miR-218 overexpression inactivated the PTEN/PI3K/AKT pathway, which was abated by Runx2 upregulation. mir-218 0-7 AKT serine/threonine kinase 1 Homo sapiens 49-52
30319270-9 2018 miR-218 overexpression inactivated the PTEN/PI3K/AKT pathway, which was abated by Runx2 upregulation. mir-218 0-7 RUNX family transcription factor 2 Homo sapiens 82-87
30319270-11 2018 Moreover, enforced expression of miR-218 inhibited tumor growth and Runx2 expression, and blocked PTEN/PI3K/AKT pathway in vivo. mir-218 33-40 RUNX family transcription factor 2 Homo sapiens 68-73
30319270-11 2018 Moreover, enforced expression of miR-218 inhibited tumor growth and Runx2 expression, and blocked PTEN/PI3K/AKT pathway in vivo. mir-218 33-40 phosphatase and tensin homolog Homo sapiens 98-102
30319270-11 2018 Moreover, enforced expression of miR-218 inhibited tumor growth and Runx2 expression, and blocked PTEN/PI3K/AKT pathway in vivo. mir-218 33-40 AKT serine/threonine kinase 1 Homo sapiens 108-111
30157923-15 2018 MiR-218 modulates the osteogenic differentiation of RA-FLS through the ROBO1/DKK-1 axis. mir-218 0-7 roundabout guidance receptor 1 Homo sapiens 71-76
30157923-15 2018 MiR-218 modulates the osteogenic differentiation of RA-FLS through the ROBO1/DKK-1 axis. mir-218 0-7 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 77-82
29977158-5 2018 As well, the relation between miR-218 and CTGF was identified. mir-218 30-37 cellular communication network factor 2 Homo sapiens 42-46
29229679-9 2018 We further identified miR-218 as a posttranscriptional negative regulator of CD16a in NK cells. mir-218 22-29 Fc gamma receptor IIIa Homo sapiens 77-82
30003726-0 2018 miR-218 suppresses the growth of hepatocellular carcinoma by inhibiting the expression of proto-oncogene Bmi-1. mir-218 0-7 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 105-110
29344251-0 2017 miR-218 inhibits acute promyelocytic leukemia cell growth by targeting BMI-1. mir-218 0-7 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 71-76
29138857-0 2018 miR-218 inhibits the proliferation of human glioma cells through downregulation of Yin Yang 1. mir-218 0-7 YY1 transcription factor Homo sapiens 83-93
28936884-0 2017 miR-218 suppresses epithelial-to-mesenchymal transition by targeting Robo1 and Ecop in lung adenocarcinoma cells. mir-218 0-7 roundabout guidance receptor 1 Homo sapiens 69-74
28936884-0 2017 miR-218 suppresses epithelial-to-mesenchymal transition by targeting Robo1 and Ecop in lung adenocarcinoma cells. mir-218 0-7 VOPP1 WW domain binding protein Homo sapiens 79-83
28192397-0 2017 Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling. mir-218 18-25 snail family transcriptional repressor 2 Homo sapiens 124-128
28864214-4 2017 Moreover, levels of serum miR-218 positively correlated with FEV1/FVC% and negatively correlated with levels of serum IL-6 and IL-8. mir-218 26-33 interleukin 6 Homo sapiens 118-122
28864214-4 2017 Moreover, levels of serum miR-218 positively correlated with FEV1/FVC% and negatively correlated with levels of serum IL-6 and IL-8. mir-218 26-33 C-X-C motif chemokine ligand 8 Homo sapiens 127-131
28849187-6 2017 Overexpression of miR-218 led to inhibition of PPP2R5A expression, whereas knockdown of miR-218 increased PPP2R5A levels. mir-218 18-25 protein phosphatase 2 regulatory subunit B'alpha Homo sapiens 47-54
28849187-7 2017 Introduction of PPP2R5A abrogated miR-218-mediated cell survival and drug resistance. mir-218 34-41 protein phosphatase 2 regulatory subunit B'alpha Homo sapiens 16-23
28323002-0 2017 miR-218 inhibited tumor angiogenesis by targeting ROBO1 in gastric cancer. mir-218 0-7 roundabout guidance receptor 1 Homo sapiens 50-55
28412444-8 2017 Overexpression of miR-218 repressed the expression of LASP1 at both the mRNA and protein level. mir-218 18-25 LIM and SH3 protein 1 Homo sapiens 54-59
28412444-9 2017 Meanwhile, miR-218 repressed the activity of a luciferase reporter containing the 3"-untranslated region of the LASP1 gene. mir-218 11-18 LIM and SH3 protein 1 Homo sapiens 112-117
28634044-0 2017 miR-218 suppresses gastric cancer cell cycle progression through the CDK6/Cyclin D1/E2F1 axis in a feedback loop. mir-218 0-7 cyclin dependent kinase 6 Homo sapiens 69-73
28634044-0 2017 miR-218 suppresses gastric cancer cell cycle progression through the CDK6/Cyclin D1/E2F1 axis in a feedback loop. mir-218 0-7 cyclin D1 Homo sapiens 74-83
28634044-0 2017 miR-218 suppresses gastric cancer cell cycle progression through the CDK6/Cyclin D1/E2F1 axis in a feedback loop. mir-218 0-7 E2F transcription factor 1 Homo sapiens 84-88
28634044-5 2017 Overexpression of CDK6 and Cyclin D1 reversed miR-218-mediated inhibition of pRB/E2F1 signaling and attenuated the miR-218-induced cell cycle arrest. mir-218 46-53 cyclin dependent kinase 6 Homo sapiens 18-22
28634044-5 2017 Overexpression of CDK6 and Cyclin D1 reversed miR-218-mediated inhibition of pRB/E2F1 signaling and attenuated the miR-218-induced cell cycle arrest. mir-218 46-53 cyclin D1 Homo sapiens 27-36
28634044-5 2017 Overexpression of CDK6 and Cyclin D1 reversed miR-218-mediated inhibition of pRB/E2F1 signaling and attenuated the miR-218-induced cell cycle arrest. mir-218 46-53 RB transcriptional corepressor 1 Homo sapiens 77-80
28634044-5 2017 Overexpression of CDK6 and Cyclin D1 reversed miR-218-mediated inhibition of pRB/E2F1 signaling and attenuated the miR-218-induced cell cycle arrest. mir-218 46-53 E2F transcription factor 1 Homo sapiens 81-85
28634044-5 2017 Overexpression of CDK6 and Cyclin D1 reversed miR-218-mediated inhibition of pRB/E2F1 signaling and attenuated the miR-218-induced cell cycle arrest. mir-218 115-122 cyclin dependent kinase 6 Homo sapiens 18-22
28634044-5 2017 Overexpression of CDK6 and Cyclin D1 reversed miR-218-mediated inhibition of pRB/E2F1 signaling and attenuated the miR-218-induced cell cycle arrest. mir-218 115-122 cyclin D1 Homo sapiens 27-36
28192397-0 2017 Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling. mir-218 18-25 zinc finger E-box binding homeobox 2 Homo sapiens 129-133
28192397-7 2017 Inverse correlations were observed between miR-218 levels and Slug/ZEB2 levels in cancer tissue samples. mir-218 43-50 snail family transcriptional repressor 2 Homo sapiens 62-66
28192397-7 2017 Inverse correlations were observed between miR-218 levels and Slug/ZEB2 levels in cancer tissue samples. mir-218 43-50 zinc finger E-box binding homeobox 2 Homo sapiens 67-71
28369267-0 2017 MiR-218 suppresses the metastasis and EMT of HCC cells via targeting SERBP1. mir-218 0-7 SERPINE1 mRNA binding protein 1 Homo sapiens 69-75
26986507-6 2016 Notably, we also found that miR-218 inhibited the expression of cell cycle regulatory protein cyclin A1 and invasion-related matrix metalloproteinase-9 protein induced by IL-6, and impeded the accelerative effect of IL-6 on LNCaP-IL-6+ cell proliferation, cell cycle progression and cell invasion. mir-218 28-35 cyclin A1 Homo sapiens 94-151
27633630-10 2016 Moreover, direct binding of miR-218 to the 3"-UTR of TPD52 was observed by dual luciferase reporter assay. mir-218 28-35 tumor protein D52 Homo sapiens 53-58
27725858-5 2016 The targeting effect of HMGB1 by miR-218 was measured with luciferase reporter assay. mir-218 33-40 high mobility group box 1 Homo sapiens 24-29
26019213-5 2016 The influence of miR-218 on its putative target genes (POU2F2, ROBO1 and IKK-beta) and GC metastasis was further explored via in vitro and in vivo approaches. mir-218 17-24 POU class 2 homeobox 2 Homo sapiens 55-61
26019213-5 2016 The influence of miR-218 on its putative target genes (POU2F2, ROBO1 and IKK-beta) and GC metastasis was further explored via in vitro and in vivo approaches. mir-218 17-24 roundabout guidance receptor 1 Homo sapiens 63-68
26019213-5 2016 The influence of miR-218 on its putative target genes (POU2F2, ROBO1 and IKK-beta) and GC metastasis was further explored via in vitro and in vivo approaches. mir-218 17-24 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 73-81
28105117-0 2016 miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2. mir-218 0-7 angiopoietin 2 Homo sapiens 84-98
27462788-8 2016 miR-218 inhibited significantly MACC1 protein expression, and consistently, MACC1-mediated migration, invasion and colony formation in CRC cells. mir-218 0-7 MET transcriptional regulator MACC1 Homo sapiens 32-37
27462788-8 2016 miR-218 inhibited significantly MACC1 protein expression, and consistently, MACC1-mediated migration, invasion and colony formation in CRC cells. mir-218 0-7 MET transcriptional regulator MACC1 Homo sapiens 76-81
27133059-12 2016 Overexpression of miR-218 mimic resulted in significant reduction in the expression of CXCR7 at protein and mRNA levels under normal and hypoxic conditions. mir-218 18-25 atypical chemokine receptor 3 Homo sapiens 87-92
26986507-6 2016 Notably, we also found that miR-218 inhibited the expression of cell cycle regulatory protein cyclin A1 and invasion-related matrix metalloproteinase-9 protein induced by IL-6, and impeded the accelerative effect of IL-6 on LNCaP-IL-6+ cell proliferation, cell cycle progression and cell invasion. mir-218 28-35 interleukin 6 Homo sapiens 171-175
26986507-6 2016 Notably, we also found that miR-218 inhibited the expression of cell cycle regulatory protein cyclin A1 and invasion-related matrix metalloproteinase-9 protein induced by IL-6, and impeded the accelerative effect of IL-6 on LNCaP-IL-6+ cell proliferation, cell cycle progression and cell invasion. mir-218 28-35 interleukin 6 Homo sapiens 216-220
26986507-6 2016 Notably, we also found that miR-218 inhibited the expression of cell cycle regulatory protein cyclin A1 and invasion-related matrix metalloproteinase-9 protein induced by IL-6, and impeded the accelerative effect of IL-6 on LNCaP-IL-6+ cell proliferation, cell cycle progression and cell invasion. mir-218 28-35 interleukin 6 Homo sapiens 216-220
26986507-7 2016 Moreover, our results confirmed that miR-218 directly targets LGR4 and modulated the PI3K/Akt and Wnt/beta-catenin pathways in the LNCaP-IL-6+ cells. mir-218 37-44 leucine rich repeat containing G protein-coupled receptor 4 Homo sapiens 62-66
26986507-7 2016 Moreover, our results confirmed that miR-218 directly targets LGR4 and modulated the PI3K/Akt and Wnt/beta-catenin pathways in the LNCaP-IL-6+ cells. mir-218 37-44 AKT serine/threonine kinase 1 Homo sapiens 90-93
26986507-7 2016 Moreover, our results confirmed that miR-218 directly targets LGR4 and modulated the PI3K/Akt and Wnt/beta-catenin pathways in the LNCaP-IL-6+ cells. mir-218 37-44 catenin beta 1 Homo sapiens 102-114
26986507-7 2016 Moreover, our results confirmed that miR-218 directly targets LGR4 and modulated the PI3K/Akt and Wnt/beta-catenin pathways in the LNCaP-IL-6+ cells. mir-218 37-44 interleukin 6 Homo sapiens 137-141
26876575-7 2016 Furthermore, inhibition of miR-218 was associated with decreased expression of the known pro-apoptotic molecule p38-mitogen-activated protein kinase (p38-MAPK) activation. mir-218 27-34 mitogen-activated protein kinase 14 Homo sapiens 112-148
26876575-7 2016 Furthermore, inhibition of miR-218 was associated with decreased expression of the known pro-apoptotic molecule p38-mitogen-activated protein kinase (p38-MAPK) activation. mir-218 27-34 mitogen-activated protein kinase 14 Homo sapiens 150-158
26703568-0 2015 MiR-218 Inhibits Erythroid Differentiation and Alters Iron Metabolism by Targeting ALAS2 in K562 Cells. mir-218 0-7 5'-aminolevulinate synthase 2 Homo sapiens 83-88
26782075-8 2016 Treatment with miR-218 inhibitors inactivated Janus kinase/signal transducer and activator of transcription 3 (STAT3) signaling in rats with CCI in vivo. mir-218 15-22 signal transducer and activator of transcription 3 Rattus norvegicus 111-116
26782075-9 2016 Moreover, miR-218 inhibitors significantly inhibited the activation of microglial cell STAT3 signaling and downstream proinflammatory genes in microglial cells. mir-218 10-17 signal transducer and activator of transcription 3 Rattus norvegicus 87-92
26889813-0 2016 MiR-218 inhibits the tumorgenesis and proliferation of glioma cells by targeting Robo1. mir-218 0-7 roundabout guidance receptor 1 Homo sapiens 81-86
26442524-7 2015 MiR-218 promoted apoptosis, inhibited cell proliferation and caused cell cycle arrest in CRC cells by suppressing BIRC5 expression. mir-218 0-7 baculoviral IAP repeat containing 5 Homo sapiens 114-119
26442524-8 2015 Furthermore, miR-218 enhanced 5-FU cytotoxicity in CRC cells by suppressing the 5-FU targeted enzyme, thymidylate synthase (TS). mir-218 13-20 thymidylate synthetase Homo sapiens 102-122
26703568-5 2015 Overexpression of miR-218 repressed erythroid differentiation and altered iron metabolism in K562 cells similar to that seen in the ALAS2 knockdown in K562 cells. mir-218 18-25 5'-aminolevulinate synthase 2 Homo sapiens 132-137
26703568-7 2015 Taken together, our results show that miR-218 inhibits erythroid differentiation and alters iron metabolism by targeting ALAS2 in K562 cells. mir-218 38-45 5'-aminolevulinate synthase 2 Homo sapiens 121-126
26133092-9 2015 Whereas, neutralization of miR-218 using the anti-miR-218 antibody reversed the effects of propofol on the biological behavior of U373 cells, and on the inhibition of MMP-2 protein expression. mir-218 27-34 matrix metallopeptidase 2 Homo sapiens 167-172
26610476-0 2015 Epigenetic Repression of miR-218 Promotes Esophageal Carcinogenesis by Targeting ROBO1. mir-218 25-32 roundabout guidance receptor 1 Homo sapiens 81-86
26157321-15 2015 miR-218 can negatively regulate the HMGB1 protein expression and inhibit the proliferation and invasion of pancreatic cancer cells. mir-218 0-7 high mobility group box 1 Homo sapiens 36-41
26157323-11 2015 miR-218 promoted the sensitivity of PANC-1 cells to GEM, which was achieved mainly through regulating the expression of HMGB1 in PANC-1 cells. mir-218 0-7 high mobility group box 1 Homo sapiens 120-125
26137139-0 2015 miR-218 inhibits the proliferation of glioma U87 cells through the inactivation of the CDK6/cyclin D1/p21Cip1/Waf1 pathway. mir-218 0-7 cyclin dependent kinase 6 Homo sapiens 87-91
25634129-10 2015 The present results suggested that miR-218 targets AdipoR2 to inhibit adiponectin signaling. mir-218 35-42 adiponectin receptor 2 Homo sapiens 51-58
25634129-10 2015 The present results suggested that miR-218 targets AdipoR2 to inhibit adiponectin signaling. mir-218 35-42 adiponectin, C1Q and collagen domain containing Homo sapiens 70-81
26261543-0 2015 MiR-218 inhibits HMGB1-mediated autophagy in endometrial carcinoma cells during chemotherapy. mir-218 0-7 high mobility group box 1 Homo sapiens 17-22
25634129-9 2015 In addition, miR-218 inhibited adiponectin-induced glucose uptake. mir-218 13-20 adiponectin, C1Q and collagen domain containing Homo sapiens 31-42
26137139-0 2015 miR-218 inhibits the proliferation of glioma U87 cells through the inactivation of the CDK6/cyclin D1/p21Cip1/Waf1 pathway. mir-218 0-7 cyclin D1 Homo sapiens 92-101
26137139-0 2015 miR-218 inhibits the proliferation of glioma U87 cells through the inactivation of the CDK6/cyclin D1/p21Cip1/Waf1 pathway. mir-218 0-7 cyclin dependent kinase inhibitor 1A Homo sapiens 102-109
26137139-0 2015 miR-218 inhibits the proliferation of glioma U87 cells through the inactivation of the CDK6/cyclin D1/p21Cip1/Waf1 pathway. mir-218 0-7 cyclin dependent kinase inhibitor 1A Homo sapiens 110-114
26137139-8 2015 The present results suggest that miR-218 plays an important role in the prevention of the proliferation of glioma cells, and the present study also revealed a novel mechanism for miRNA-mediated direct suppression of the CDK6/cyclin D1/p21Cip1/Waf1 pathway in glioma cells. mir-218 33-40 cyclin dependent kinase 6 Homo sapiens 220-224
26137139-8 2015 The present results suggest that miR-218 plays an important role in the prevention of the proliferation of glioma cells, and the present study also revealed a novel mechanism for miRNA-mediated direct suppression of the CDK6/cyclin D1/p21Cip1/Waf1 pathway in glioma cells. mir-218 33-40 cyclin D1 Homo sapiens 225-234
26137139-8 2015 The present results suggest that miR-218 plays an important role in the prevention of the proliferation of glioma cells, and the present study also revealed a novel mechanism for miRNA-mediated direct suppression of the CDK6/cyclin D1/p21Cip1/Waf1 pathway in glioma cells. mir-218 33-40 cyclin dependent kinase inhibitor 1A Homo sapiens 235-242
26137139-8 2015 The present results suggest that miR-218 plays an important role in the prevention of the proliferation of glioma cells, and the present study also revealed a novel mechanism for miRNA-mediated direct suppression of the CDK6/cyclin D1/p21Cip1/Waf1 pathway in glioma cells. mir-218 33-40 cyclin dependent kinase inhibitor 1A Homo sapiens 243-247
24973709-3 2014 Overexpression of miR-218 inhibited cell growth arrest at G2/M phase, suppressed the protein levels of cyclin A and up-regulated the expression levels of p27 through decreasing the levels of Fbxw8. mir-218 18-25 cyclin A2 Homo sapiens 103-111
25760926-0 2015 miR-218 inhibits the invasion and migration of colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. mir-218 0-7 AKT serine/threonine kinase 1 Homo sapiens 88-91
25760926-0 2015 miR-218 inhibits the invasion and migration of colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. mir-218 0-7 mechanistic target of rapamycin kinase Homo sapiens 92-96
25760926-8 2015 The upregulation of miR-218 inhibited the activation of the PI3K/Akt/mTOR signaling pathway, as well as the expression of matrix metalloproteinase (MMP)9. mir-218 20-27 AKT serine/threonine kinase 1 Homo sapiens 65-68
25760926-8 2015 The upregulation of miR-218 inhibited the activation of the PI3K/Akt/mTOR signaling pathway, as well as the expression of matrix metalloproteinase (MMP)9. mir-218 20-27 mechanistic target of rapamycin kinase Homo sapiens 69-73
25760926-8 2015 The upregulation of miR-218 inhibited the activation of the PI3K/Akt/mTOR signaling pathway, as well as the expression of matrix metalloproteinase (MMP)9. mir-218 20-27 matrix metallopeptidase 9 Homo sapiens 122-153
25760926-10 2015 Taken together, our results demonstrate that miR-218 suppresses the proliferation, migration and invasion of LoVo colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway and MMP9. mir-218 45-52 AKT serine/threonine kinase 1 Homo sapiens 155-158
25760926-10 2015 Taken together, our results demonstrate that miR-218 suppresses the proliferation, migration and invasion of LoVo colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway and MMP9. mir-218 45-52 mechanistic target of rapamycin kinase Homo sapiens 159-163
25760926-10 2015 Taken together, our results demonstrate that miR-218 suppresses the proliferation, migration and invasion of LoVo colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway and MMP9. mir-218 45-52 matrix metallopeptidase 9 Homo sapiens 186-190
25812649-0 2015 miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D. mir-218 0-7 myocyte enhancer factor 2D Homo sapiens 61-87
25812649-6 2015 Altogether, we found that miR-218/MEF2D may be an effective target for myxoma treatment. mir-218 26-33 myocyte enhancer factor 2D Homo sapiens 34-39
25374061-0 2015 Overexpression of miR-218 inhibits hepatocellular carcinoma cell growth through RET. mir-218 18-25 ret proto-oncogene Homo sapiens 80-83
25789001-0 2015 miR-218 inhibits the migration and invasion of glioma U87 cells through the Slit2-Robo1 pathway. mir-218 0-7 slit guidance ligand 2 Homo sapiens 76-81
25789001-0 2015 miR-218 inhibits the migration and invasion of glioma U87 cells through the Slit2-Robo1 pathway. mir-218 0-7 roundabout guidance receptor 1 Homo sapiens 82-87
24973709-3 2014 Overexpression of miR-218 inhibited cell growth arrest at G2/M phase, suppressed the protein levels of cyclin A and up-regulated the expression levels of p27 through decreasing the levels of Fbxw8. mir-218 18-25 interferon alpha inducible protein 27 Homo sapiens 154-157
24973709-3 2014 Overexpression of miR-218 inhibited cell growth arrest at G2/M phase, suppressed the protein levels of cyclin A and up-regulated the expression levels of p27 through decreasing the levels of Fbxw8. mir-218 18-25 F-box and WD repeat domain containing 8 Homo sapiens 191-196
24696000-8 2014 We concluded that miR-218 might have a role in the transformation of hematopoietic cells through the MITF pathway. mir-218 18-25 melanocyte inducing transcription factor Homo sapiens 101-105
23243056-0 2013 MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOP-mediated suppression of NF-kappaB activity. mir-218 0-7 VOPP1 WW domain binding protein Homo sapiens 87-91
23950210-5 2013 We documented that miR-218 also blocked the self-renewal of glioma stem-like cells, consistent with the suggested role of Bmi1 in stem cell growth. mir-218 19-26 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 122-126
23996750-6 2013 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions (P<0.05). mir-218 22-29 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 149-154
23996750-6 2013 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions (P<0.05). mir-218 22-29 cyclin dependent kinase 6 Homo sapiens 159-163
23255074-8 2013 Ectopic expression of miR-218 in HCT116 and HT29 cells suppressed BMI-1 mRNA and protein expression. mir-218 22-29 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 66-71
22766851-12 2012 We, therefore, hypothesize that miR-218 directly targets LEF1, resulting in reduced synthesis of MMP-9. mir-218 32-39 lymphoid enhancer binding factor 1 Homo sapiens 57-61
22766851-12 2012 We, therefore, hypothesize that miR-218 directly targets LEF1, resulting in reduced synthesis of MMP-9. mir-218 32-39 matrix metallopeptidase 9 Homo sapiens 109-114