PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28395284-13	2017	Furthermore, Co-IP assay revealed K63 de-ubiquitination of RIP1 by I3C, associated with the induction of caspase 8.	ip	16-18	caspase 8	Rattus norvegicus	105-114
29042581-10	2017	Taken together, deficiency of IP subunit beta5i/LMP7 does not disturb protein homeostasis and does not aggravate atherogenesis in LDLR-/- mice.	ip	30-32	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	Mus musculus	48-52
26791829-8	2016	The IP Group showed a significant increase in M2 macrophages and FOXP3(+)cells in the infarcted and peri-infarcted areas, a significantly higher frequency of circulating Treg cells (CD4(+)CD25(+)FOXP3(+)), and a less extreme decrease in conventional T cells (CD25(+)FOXP3(-)) compared with the I Group.	ip	4-6	forkhead box P3	Rattus norvegicus	65-70
26791829-8	2016	The IP Group showed a significant increase in M2 macrophages and FOXP3(+)cells in the infarcted and peri-infarcted areas, a significantly higher frequency of circulating Treg cells (CD4(+)CD25(+)FOXP3(+)), and a less extreme decrease in conventional T cells (CD25(+)FOXP3(-)) compared with the I Group.	ip	4-6	forkhead box P3	Rattus norvegicus	195-200
26791829-8	2016	The IP Group showed a significant increase in M2 macrophages and FOXP3(+)cells in the infarcted and peri-infarcted areas, a significantly higher frequency of circulating Treg cells (CD4(+)CD25(+)FOXP3(+)), and a less extreme decrease in conventional T cells (CD25(+)FOXP3(-)) compared with the I Group.	ip	4-6	forkhead box P3	Rattus norvegicus	195-200
26427787-4	2015	METHODS: Cirrhosis was induced with carbon tetrachloride (CCl4) (ip) in C57BL/6 mice for 6 weeks.	ip	65-67	chemokine (C-C motif) ligand 4	Mus musculus	58-62
25073857-6	2016	C-reactive protein decreased, but the effect was significantly greater in the IS group (-32%, p < 0.0001) than in the IP group (-5%, p = 0.0005).	ip	121-123	C-reactive protein	Homo sapiens	0-18
25132256-8	2014	RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression.	ip	47-49	tumor necrosis factor	Rattus norvegicus	185-194
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	toll like receptor 4	Homo sapiens	44-48
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	toll like receptor 4	Homo sapiens	92-96
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	MYD88 innate immune signal transduction adaptor	Homo sapiens	98-103
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	interleukin 1 beta	Homo sapiens	105-113
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	tumor necrosis factor	Homo sapiens	115-124
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	NFKB inhibitor alpha	Homo sapiens	151-164
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	BCL2 apoptosis regulator	Homo sapiens	169-174
25888780-16	2015	The PGIS/IP signaling pathway is a potential therapeutic strategy for chronic brain injury patients.	ip	9-11	prostaglandin I2 synthase	Homo sapiens	4-8
26188701-4	2015	Both of these prostanoids activate G-protein coupled receptors: EP1, EP2, EP3 and EP4 by PGE2 and IP by prostacyclin.	ip	98-100	prostaglandin E receptor 4	Homo sapiens	82-85
25132256-8	2014	RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression.	ip	47-49	interleukin 1 beta	Rattus norvegicus	196-204
25132256-8	2014	RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression.	ip	47-49	nuclear factor of activated T-cells 4	Rattus norvegicus	209-215
25132256-8	2014	RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression.	ip	47-49	tumor necrosis factor	Rattus norvegicus	253-262
25132256-8	2014	RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression.	ip	47-49	interleukin 1 beta	Rattus norvegicus	267-275
24270408-3	2014	We increased cGMP in the gut of Prkg2(+/+) and Prkg2(-/-) mice by treating with the PDE5 inhibitor Vardenafil (IP).	ip	111-113	protein kinase, cGMP-dependent, type II	Mus musculus	32-37
24854918-14	2014	CONCLUSION: CaSR mediates hypoxia-induced airway mucous hypersecretion through a signaling pathway of Galphaq/11/PLC/inositol 1, 4, 5-triphosphate (IP 3)/[Ca2+]i.	ip	148-150	calcium sensing receptor	Homo sapiens	12-16
24270408-3	2014	We increased cGMP in the gut of Prkg2(+/+) and Prkg2(-/-) mice by treating with the PDE5 inhibitor Vardenafil (IP).	ip	111-113	protein kinase, cGMP-dependent, type II	Mus musculus	47-52
24270408-3	2014	We increased cGMP in the gut of Prkg2(+/+) and Prkg2(-/-) mice by treating with the PDE5 inhibitor Vardenafil (IP).	ip	111-113	phosphodiesterase 5A, cGMP-specific	Mus musculus	84-88
23294923-4	2013	apoE3 upregulated expression of the cdk inhibitor, p27(kip1), in primary VSMCs, and this effect required Cox2 and activation of PGI(2)-IP signaling.	ip	135-137	cyclin-dependent kinase inhibitor 1B	Mus musculus	51-54
23107353-2	2013	The InsuPatch (IP) is a novel insulin infusion site warming device developed to accelerate insulin action by increasing blood flow to the area of insulin absorption.	ip	15-17	insulin	Homo sapiens	30-37
23107353-2	2013	The InsuPatch (IP) is a novel insulin infusion site warming device developed to accelerate insulin action by increasing blood flow to the area of insulin absorption.	ip	15-17	insulin	Homo sapiens	91-98
23107353-2	2013	The InsuPatch (IP) is a novel insulin infusion site warming device developed to accelerate insulin action by increasing blood flow to the area of insulin absorption.	ip	15-17	insulin	Homo sapiens	91-98
23294923-5	2013	The microRNA family, miR221/222 has recently been identified as a post-translational regulator of p27, and apoE3 inhibited miR221/222 expression in a Cox2- and PGI(2)/IP-dependent manner.	ip	167-169	microRNA 221	Mus musculus	21-27
23294923-5	2013	The microRNA family, miR221/222 has recently been identified as a post-translational regulator of p27, and apoE3 inhibited miR221/222 expression in a Cox2- and PGI(2)/IP-dependent manner.	ip	167-169	cyclin-dependent kinase inhibitor 1B	Mus musculus	98-101
23294923-5	2013	The microRNA family, miR221/222 has recently been identified as a post-translational regulator of p27, and apoE3 inhibited miR221/222 expression in a Cox2- and PGI(2)/IP-dependent manner.	ip	167-169	microRNA 221	Mus musculus	123-129
22889849-4	2012	KCS1 encodes an inositol hexakisphosphate/heptakisposphate kinase that synthesizes 5-IP(7) and IP(8); and IPK2 encodes an inositol polyphosphate multikinase required for synthesis of IP(4) and IP(5).	ip	85-87	inositol polyphosphate kinase KCS1	Saccharomyces cerevisiae S288C	0-4
23255604-2	2013	Inositol hexakisphosphate kinase 1 (IP6K1) participates in inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6)) to IP(7).	ip	131-133	inositol hexaphosphate kinase 1	Mus musculus	36-41
22969152-1	2012	Prostacyclin and its prostacyclin receptor, the I Prostanoid (IP), play essential roles in regulating hemostasis and vascular tone and have been implicated in a range cardio-protective effects but through largely unknown mechanisms.	ip	62-64	prostaglandin I2 receptor	Homo sapiens	21-42
22484374-3	2012	LPL activates phospholipase C (PLC), and resulting inositol trisphosphate (IP(3)) and diacylglycerol contribute to PKCalpha activation and downstream activation of ERK1/2.	ip	75-77	protein kinase C, alpha	Mus musculus	115-123
22484374-3	2012	LPL activates phospholipase C (PLC), and resulting inositol trisphosphate (IP(3)) and diacylglycerol contribute to PKCalpha activation and downstream activation of ERK1/2.	ip	75-77	mitogen-activated protein kinase 3	Mus musculus	164-170
22889849-4	2012	KCS1 encodes an inositol hexakisphosphate/heptakisposphate kinase that synthesizes 5-IP(7) and IP(8); and IPK2 encodes an inositol polyphosphate multikinase required for synthesis of IP(4) and IP(5).	ip	95-97	inositol polyphosphate kinase KCS1	Saccharomyces cerevisiae S288C	0-4
22889849-4	2012	KCS1 encodes an inositol hexakisphosphate/heptakisposphate kinase that synthesizes 5-IP(7) and IP(8); and IPK2 encodes an inositol polyphosphate multikinase required for synthesis of IP(4) and IP(5).	ip	95-97	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	106-110
22889849-4	2012	KCS1 encodes an inositol hexakisphosphate/heptakisposphate kinase that synthesizes 5-IP(7) and IP(8); and IPK2 encodes an inositol polyphosphate multikinase required for synthesis of IP(4) and IP(5).	ip	95-97	inositol polyphosphate kinase KCS1	Saccharomyces cerevisiae S288C	0-4
22889849-4	2012	KCS1 encodes an inositol hexakisphosphate/heptakisposphate kinase that synthesizes 5-IP(7) and IP(8); and IPK2 encodes an inositol polyphosphate multikinase required for synthesis of IP(4) and IP(5).	ip	95-97	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	106-110
22064466-4	2011	An important step during this maturation process occurs at the cytoplasmic face of the nuclear pore complex (NPC) where the export protein Gle1 bound to inositol hexakisphosphate (IP 6) spatially activates the ATP-hydrolysis and mRNP-remodeling activity of the DEAD-box protein Dbp5.	ip	180-182	DEAD-box helicase 19B	Homo sapiens	278-282
22584673-9	2012	SSB and CS demonstrated more tolerable IP levels in this position of < 40 mmHg, which was similar to those when sitting.	ip	39-41	small RNA binding exonuclease protection factor La	Homo sapiens	0-3
22167199-6	2012	Pharmacological inhibition and/or siRNA-mediated silencing of various signaling actors acting downstream of beta2ADR in a sequential manner, such as G protein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-trisphosphate (IP(3))/IP(3) receptor, were next demonstrated to prevent B(a)P-induced calcium signal.	ip	228-230	adrenoceptor beta 2	Homo sapiens	108-116
22167199-8	2012	Taken together, our results show that B(a)P binds directly to beta2ADR and consequently utilizes beta2ADR machinery to mobilize [Ca(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.	ip	204-206	adrenoceptor beta 2	Homo sapiens	62-70
22167199-8	2012	Taken together, our results show that B(a)P binds directly to beta2ADR and consequently utilizes beta2ADR machinery to mobilize [Ca(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.	ip	204-206	adrenoceptor beta 2	Homo sapiens	97-105
22112806-5	2012	RESULTS: Substitution Pro639Leu fully inactivates the promiscuous TSHR for cAMP (Gs) and IP (Gq) signaling.	ip	89-91	thyroid stimulating hormone receptor	Homo sapiens	66-70
22007900-9	2012	The results of a PLC activity assay showed a reduction in the accumulation of inositol-1,4,5-trisphosphate (IP(3)) in atplc9 during HS and improved IP(3) generation in the overexpressed lines.	ip	108-110	phosphatidylinositol-speciwc phospholipase C9	Arabidopsis thaliana	118-124
22064466-4	2011	An important step during this maturation process occurs at the cytoplasmic face of the nuclear pore complex (NPC) where the export protein Gle1 bound to inositol hexakisphosphate (IP 6) spatially activates the ATP-hydrolysis and mRNP-remodeling activity of the DEAD-box protein Dbp5.	ip	180-182	GLE1 RNA export mediator	Homo sapiens	139-143
22745128-1	2012	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) catalyzes the synthesis of inositol 1,2,3,4,5,6-hexakisphosphate from ATP and IP(5).	ip	47-49	inositol-pentakisphosphate 2-kinase	Homo sapiens	0-45
22074661-6	2012	Based on the analysis of global changes in protein expression patterns, our findings underline the complexity of gain-of-function TSHR signaling in thyrocytes, which extends beyond pure cAMP and/or IP formation.	ip	198-200	thyroid stimulating hormone receptor	Rattus norvegicus	130-134
22153127-7	2012	We also found that by a still undefined mechanism Yvc1 activation seems to correlate with the changes in the intracellular level of IP(3).	ip	132-134	Yvc1p	Saccharomyces cerevisiae S288C	50-54
22613970-3	2012	We have previously shown that beta-cells of mice lacking one copy of the Annexin 7 gene (Anx7(+/-)) express reduced levels of IP(3) receptors and defects in IP(3)-dependent Ca(2+) signaling.	ip	126-128	annexin A7	Mus musculus	73-82
22613970-3	2012	We have previously shown that beta-cells of mice lacking one copy of the Annexin 7 gene (Anx7(+/-)) express reduced levels of IP(3) receptors and defects in IP(3)-dependent Ca(2+) signaling.	ip	126-128	annexin A7	Mus musculus	89-93
21949122-2	2011	During messenger (m)RNA export, Gle1 bound to inositol hexakisphosphate (IP(6)) acts via Dbp5 to facilitate remodeling of mRNA-protein complexes.	ip	73-75	GLE1 RNA export mediator	Homo sapiens	32-36
21949122-2	2011	During messenger (m)RNA export, Gle1 bound to inositol hexakisphosphate (IP(6)) acts via Dbp5 to facilitate remodeling of mRNA-protein complexes.	ip	73-75	DEAD-box helicase 19B	Homo sapiens	89-93
21795740-4	2011	After 16 weeks, IP-TFA intake increased baseline-adjusted serum tumor necrosis factor (TNF) alpha by 12% [95% confidence interval (CI): 5-20; P = 0.002] more in the IP-TFA group compared with controls.	ip	16-18	tumor necrosis factor	Homo sapiens	64-85
21795740-4	2011	After 16 weeks, IP-TFA intake increased baseline-adjusted serum tumor necrosis factor (TNF) alpha by 12% [95% confidence interval (CI): 5-20; P = 0.002] more in the IP-TFA group compared with controls.	ip	16-18	tumor necrosis factor	Homo sapiens	87-90
21795740-7	2011	In conclusion, this dietary trial indicates that the mechanisms linking dietary IP-TFA to cardiovascular disease may involve activation of the TNFalpha system.	ip	80-82	tumor necrosis factor	Homo sapiens	143-151
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	ip	197-199	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	10-14
21712085-5	2011	2",5"-DHC treatment induced phosphorylation of the c-Jun N-terminal kinase (JNK) pathway, which was also inhibited by MnTDE-1,3-IP(5+).	ip	128-130	mitogen-activated protein kinase 8	Homo sapiens	51-74
21712085-5	2011	2",5"-DHC treatment induced phosphorylation of the c-Jun N-terminal kinase (JNK) pathway, which was also inhibited by MnTDE-1,3-IP(5+).	ip	128-130	mitogen-activated protein kinase 8	Homo sapiens	76-79
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	ip	197-199	phospholipase C beta 3	Homo sapiens	62-83
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	ip	197-199	phospholipase C beta 3	Homo sapiens	85-95
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	ip	197-199	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	112-116
21868363-3	2011	Activated Tpl2 promoted the phosphorylation and activation of phospholipase C-beta3 (PLCbeta(3)); consequently, Tpl2 was required for thrombin-dependent production of inositol 1,4,5-trisphosphate (IP(3)), IP(3)-mediated cytoplasmic calcium ion (Ca(2+)) signals, and the activation of classical and novel members of the protein kinase C (PKC) family.	ip	197-199	coagulation factor II, thrombin	Homo sapiens	134-142
21550988-1	2011	Regulation of inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)R) by IP(3) and Ca(2+) allows them to initiate and regeneratively propagate intracellular Ca(2+) signals.	ip	44-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-68
21597914-8	2011	Secretin augmented phospholipase C (PLC) activity and increased inositol-1,4,5-triphosphate (IP(3)) levels in PC12 cells; PLC-beta inhibition blocked secretin-induced catecholamine secretion, indicating the participation of intracellular Ca(2+) from a phospholipase pathway in secretion.	ip	93-95	secretin	Rattus norvegicus	0-8
21576265-3	2011	This requires Dbp5 interaction with Nup159 in NPC cytoplasmic filaments and activation of Dbp5"s ATPase activity by Gle1 bound to inositol hexakisphosphate (IP(6)).	ip	157-159	ATP-dependent RNA helicase DBP5	Saccharomyces cerevisiae S288C	90-94
21576265-3	2011	This requires Dbp5 interaction with Nup159 in NPC cytoplasmic filaments and activation of Dbp5"s ATPase activity by Gle1 bound to inositol hexakisphosphate (IP(6)).	ip	157-159	nucleoporin GLE1	Saccharomyces cerevisiae S288C	116-120
21576266-2	2011	At cytoplasmic NPC filaments, the ATPase activity of DEAD-box protein Dbp5 is activated by inositol hexakisphosphate (IP(6))-bound Gle1 to mediate remodeling of mRNA-protein (mRNP) complexes.	ip	118-120	DEAD-box helicase 19B	Homo sapiens	70-74
21576266-2	2011	At cytoplasmic NPC filaments, the ATPase activity of DEAD-box protein Dbp5 is activated by inositol hexakisphosphate (IP(6))-bound Gle1 to mediate remodeling of mRNA-protein (mRNP) complexes.	ip	118-120	GLE1 RNA export mediator	Homo sapiens	131-135
21047792-2	2011	In most cell types, the liganded PTHR1 activates Galpha(S)/adenylyl cyclase/cAMP/PKA (cAMP/PKA) and Galpha(q/11)/phospholipase C/phosphatidylinositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/PKC (IP(3)/PKC) signaling pathways, but the relative roles of each pathway in mediating renal regulation P(i) transport remain uncertain.	ip	171-173	parathyroid hormone 1 receptor	Homo sapiens	33-38
21471355-6	2011	Enhancement of NMDAR plasticity results from an increase in the potency of inositol 1,4,5-trisphosphate (IP(3)) in producing facilitation of action potential-evoked Ca(2+) signals, which is critical for LTP induction.	ip	105-107	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	15-20
21317537-4	2011	Here, we have shown that pancreatic ductal secretion in mice is suppressed by silencing of the NBCe1-B/CFTR activator inositol-1,4,5-trisphosphate (IP(3)) receptor-binding protein released with IP(3) (IRBIT) and by inhibition of protein phosphatase 1 (PP1).	ip	148-150	cystic fibrosis transmembrane conductance regulator	Mus musculus	103-107
21317537-4	2011	Here, we have shown that pancreatic ductal secretion in mice is suppressed by silencing of the NBCe1-B/CFTR activator inositol-1,4,5-trisphosphate (IP(3)) receptor-binding protein released with IP(3) (IRBIT) and by inhibition of protein phosphatase 1 (PP1).	ip	148-150	S-adenosylhomocysteine hydrolase-like 1	Mus musculus	201-206
21317537-4	2011	Here, we have shown that pancreatic ductal secretion in mice is suppressed by silencing of the NBCe1-B/CFTR activator inositol-1,4,5-trisphosphate (IP(3)) receptor-binding protein released with IP(3) (IRBIT) and by inhibition of protein phosphatase 1 (PP1).	ip	148-150	protein phosphatase 1 catalytic subunit gamma	Mus musculus	229-250
21317537-4	2011	Here, we have shown that pancreatic ductal secretion in mice is suppressed by silencing of the NBCe1-B/CFTR activator inositol-1,4,5-trisphosphate (IP(3)) receptor-binding protein released with IP(3) (IRBIT) and by inhibition of protein phosphatase 1 (PP1).	ip	148-150	protein phosphatase 1 catalytic subunit gamma	Mus musculus	252-255
19955438-3	2009	After activation, Itk phosphorylates and activates phospholipase C-gamma1 (PLC-gamma1), leading to production of two second messengers, DAG and IP(3).	ip	144-146	IL2 inducible T cell kinase	Homo sapiens	18-21
20889566-7	2010	IGF2R RNAi also down-regulated the production of the IP-10 chemokine in HIV-infected human microglia.	ip	53-55	insulin-like growth factor 2 receptor	Mus musculus	0-5
20371601-5	2010	Here, we characterize the biochemical interaction between Gle1 and IP(6) and the relationship to Dbp5 binding and stimulation.	ip	67-69	nucleoporin GLE1	Saccharomyces cerevisiae S288C	58-62
20102549-5	2010	The knock-down of endogenous GASP-1 impairs the US28-mediated Galphaq/PLC/inositol phosphate (IP) accumulation as well as the activation of the transcription factors Nuclear Factor-kappaB (NF-kappaB) and cyclic AMP responsive element binding protein (CREB).	ip	94-96	G protein-coupled receptor associated sorting protein 1	Homo sapiens	29-35
20102549-5	2010	The knock-down of endogenous GASP-1 impairs the US28-mediated Galphaq/PLC/inositol phosphate (IP) accumulation as well as the activation of the transcription factors Nuclear Factor-kappaB (NF-kappaB) and cyclic AMP responsive element binding protein (CREB).	ip	94-96	envelope protein US28	Human betaherpesvirus 5	48-52
19932487-1	2010	This paper described a facile method for preparation of gold nanoparticles with high efficient SERS activity within short reaction time in the presence of an environmentally benign and low-cost reagent named inositol hexaphosphate (IP(6)).	ip	232-234	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	95-99
20719962-3	2010	Overexpression of Spry1 and Spry2 was associated with decreased PLCgamma phosphorylation and decreased PLCgamma activity as measured by production of inositol (1,4,5)-triphosphate (IP(3)) and diacylglycerol, whereas cells deficient for Spry1 or Spry1, -2, and -4 showed increased production of IP(3) at baseline and further increased in response to growth factor signals.	ip	181-183	sprouty RTK signaling antagonist 1	Mus musculus	18-23
20719962-3	2010	Overexpression of Spry1 and Spry2 was associated with decreased PLCgamma phosphorylation and decreased PLCgamma activity as measured by production of inositol (1,4,5)-triphosphate (IP(3)) and diacylglycerol, whereas cells deficient for Spry1 or Spry1, -2, and -4 showed increased production of IP(3) at baseline and further increased in response to growth factor signals.	ip	181-183	sprouty RTK signaling antagonist 2	Mus musculus	28-33
20719962-3	2010	Overexpression of Spry1 and Spry2 was associated with decreased PLCgamma phosphorylation and decreased PLCgamma activity as measured by production of inositol (1,4,5)-triphosphate (IP(3)) and diacylglycerol, whereas cells deficient for Spry1 or Spry1, -2, and -4 showed increased production of IP(3) at baseline and further increased in response to growth factor signals.	ip	294-296	sprouty RTK signaling antagonist 1	Mus musculus	18-23
20719962-3	2010	Overexpression of Spry1 and Spry2 was associated with decreased PLCgamma phosphorylation and decreased PLCgamma activity as measured by production of inositol (1,4,5)-triphosphate (IP(3)) and diacylglycerol, whereas cells deficient for Spry1 or Spry1, -2, and -4 showed increased production of IP(3) at baseline and further increased in response to growth factor signals.	ip	294-296	sprouty RTK signaling antagonist 2	Mus musculus	28-33
20403362-9	2010	Taken together, our results suggest that the prostacyclin/IP pathway suppresses cardiac fibrosis, at least partly, by inducing CREB phosphorylation.	ip	58-60	cAMP responsive element binding protein 1	Mus musculus	127-131
20167705-6	2010	The Tec family kinase Bruton tyrosine kinase (Btk) is required for activating both pathways, generating inositol-3,4,5-trisphosphate (IP(3)), and inducing E-selectin-mediated slow rolling.	ip	134-136	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	22-44
20167705-6	2010	The Tec family kinase Bruton tyrosine kinase (Btk) is required for activating both pathways, generating inositol-3,4,5-trisphosphate (IP(3)), and inducing E-selectin-mediated slow rolling.	ip	134-136	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	46-49
20305779-2	2010	The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (IP).	ip	100-102	thyroid stimulating hormone receptor	Homo sapiens	4-24
20305779-2	2010	The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (IP).	ip	100-102	thyroid stimulating hormone receptor	Homo sapiens	26-30
20068007-7	2010	Furthermore, the specific inhibition of MyH9 ATPase activity with Blebbistatin dose-dependently suppressed FSH-induced G alpha h/PLC-delta 1 signaling and Ca(2+)-influx, but not intracellular cAMP accumulation in rat SCs, implying that MyH9 mediates FSH-induced activation of G alpha h/PLC-delta 1/IP(3)/Ca(2+)-influx pathway in rat SCs.	ip	298-300	myosin heavy chain 9-like 1	Rattus norvegicus	40-44
20016202-7	2010	Using a novel method to monitor increases in intracellular calcium across the in vitro MEJ, we noted that PMA and FGF-2 both inhibited movement of inositol 1,4,5-triphosphate (IP(3)), but to a lesser extent Ca(2+).	ip	176-178	fibroblast growth factor 2	Mus musculus	114-119
19955438-3	2009	After activation, Itk phosphorylates and activates phospholipase C-gamma1 (PLC-gamma1), leading to production of two second messengers, DAG and IP(3).	ip	144-146	phospholipase C gamma 1	Homo sapiens	51-73
19955438-3	2009	After activation, Itk phosphorylates and activates phospholipase C-gamma1 (PLC-gamma1), leading to production of two second messengers, DAG and IP(3).	ip	144-146	phospholipase C gamma 1	Homo sapiens	75-85
19193722-5	2009	IP markedly increased the activity of NOX, resulting in increased superoxide formation, manganese superoxide dismutase (MnSOD) activity and expression, and heat shock protein (HSP)-27 expression in kidneys.	ip	0-2	superoxide dismutase 2, mitochondrial	Mus musculus	88-118
19726710-7	2009	Conversely, the anorexic response to 4th-icv leptin was completely blocked by IP devazepide, a CCKA-R antagonist, suggesting that hindbrain leptin reduces intake via a mechanism requiring endogenous CCK signaling.	ip	78-80	cholecystokinin	Homo sapiens	95-98
19624532-6	2009	Correspondingly, the clinical utility of IP (prostacyclin) antagonists is assessed in relation to the cloud hanging over the long-term safety of selective COX-2 inhibitors.	ip	41-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
19482943-1	2009	Inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) is a key regulatory enzyme at the branch point for the synthesis of inositol hexakisphosphate (IP(6)), an intracellular signaling molecule implicated in the regulation of ion channels, endocytosis, exocytosis, transcription, DNA repair, and RNA export from the nucleus.	ip	143-145	inositol 1,3,4-triphosphate 5/6 kinase	Mus musculus	0-39
19482943-1	2009	Inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) is a key regulatory enzyme at the branch point for the synthesis of inositol hexakisphosphate (IP(6)), an intracellular signaling molecule implicated in the regulation of ion channels, endocytosis, exocytosis, transcription, DNA repair, and RNA export from the nucleus.	ip	143-145	inositol 1,3,4-triphosphate 5/6 kinase	Mus musculus	41-46
19474060-9	2009	Testosterone-induced ERK1/2 and S6K1 phosphorylation increases were blocked by either 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid-acetoxymethylester or by inhibitors of inositol 1,4,5-trisphosphate (IP(3)) pathway: U-73122 and 2-aminoethyl diphenylborate.	ip	210-212	mitogen-activated protein kinase 3	Homo sapiens	21-27
19474060-9	2009	Testosterone-induced ERK1/2 and S6K1 phosphorylation increases were blocked by either 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid-acetoxymethylester or by inhibitors of inositol 1,4,5-trisphosphate (IP(3)) pathway: U-73122 and 2-aminoethyl diphenylborate.	ip	210-212	ribosomal protein S6 kinase B1	Homo sapiens	32-36
19193722-5	2009	IP markedly increased the activity of NOX, resulting in increased superoxide formation, manganese superoxide dismutase (MnSOD) activity and expression, and heat shock protein (HSP)-27 expression in kidneys.	ip	0-2	superoxide dismutase 2, mitochondrial	Mus musculus	120-125
19193722-5	2009	IP markedly increased the activity of NOX, resulting in increased superoxide formation, manganese superoxide dismutase (MnSOD) activity and expression, and heat shock protein (HSP)-27 expression in kidneys.	ip	0-2	heat shock protein 1	Mus musculus	156-183
19751316-4	2009	The antagonist properties of EMPA were determined by Schild analysis using the orexin-A- or orexin-B-induced accumulation of [(3)H]inositol phosphates (IP).	ip	152-154	hypocretin	Mus musculus	92-100
20161229-3	2009	These intracellular effectors will be the subject of this brief review on contractile activity initiated by endothelin-1 and angiotensin II.Activation of receptors by endothelin-1 and angiotensin II in smooth muscle cells results in phopholipase C (PLC) activation leading to the generation of the second messengers insitol trisphosphate (IP(3)) and diacylglycerol (DAG).	ip	339-341	endothelin 1	Homo sapiens	108-120
20161229-3	2009	These intracellular effectors will be the subject of this brief review on contractile activity initiated by endothelin-1 and angiotensin II.Activation of receptors by endothelin-1 and angiotensin II in smooth muscle cells results in phopholipase C (PLC) activation leading to the generation of the second messengers insitol trisphosphate (IP(3)) and diacylglycerol (DAG).	ip	339-341	angiotensinogen	Homo sapiens	125-139
20161229-3	2009	These intracellular effectors will be the subject of this brief review on contractile activity initiated by endothelin-1 and angiotensin II.Activation of receptors by endothelin-1 and angiotensin II in smooth muscle cells results in phopholipase C (PLC) activation leading to the generation of the second messengers insitol trisphosphate (IP(3)) and diacylglycerol (DAG).	ip	339-341	endothelin 1	Homo sapiens	167-179
20161229-3	2009	These intracellular effectors will be the subject of this brief review on contractile activity initiated by endothelin-1 and angiotensin II.Activation of receptors by endothelin-1 and angiotensin II in smooth muscle cells results in phopholipase C (PLC) activation leading to the generation of the second messengers insitol trisphosphate (IP(3)) and diacylglycerol (DAG).	ip	339-341	angiotensinogen	Homo sapiens	184-198
19590192-4	2009	RESULTS: Xenopus oocytes expressing AT1 or AT2 generated oscillatory chloride currents by coupling to the diacylglycerol/inositol-3-phosphate (DAG/IP(3)) cascade.	ip	147-149	angiotensin II receptor type 1 L homeolog	Xenopus laevis	36-39
19047484-1	2009	We show here that the rat vasopressin V(1b) receptor simultaneously activates both the G(q/11)-inositol phosphate (IP) and G(s)-cAMP pathways when transiently expressed in Chinese hamster ovary, human embryonic kidney (HEK) 293, and COS-7 cells and stimulated with arginine-vasopressin.	ip	115-117	arginine vasopressin receptor 1B	Rattus norvegicus	26-52
19047484-1	2009	We show here that the rat vasopressin V(1b) receptor simultaneously activates both the G(q/11)-inositol phosphate (IP) and G(s)-cAMP pathways when transiently expressed in Chinese hamster ovary, human embryonic kidney (HEK) 293, and COS-7 cells and stimulated with arginine-vasopressin.	ip	115-117	arginine vasopressin	Homo sapiens	26-37
19590192-4	2009	RESULTS: Xenopus oocytes expressing AT1 or AT2 generated oscillatory chloride currents by coupling to the diacylglycerol/inositol-3-phosphate (DAG/IP(3)) cascade.	ip	147-149	angiotensin II receptor type 2 L homeolog	Xenopus laevis	43-46
19108609-10	2008	Low-Pi signal is transmitted via certain inositol polyphosphate (IP) species (IP7) that are synthesized by Vip1 IP6 kinase.	ip	65-67	inositol polyphosphate kinase VIP1	Saccharomyces cerevisiae S288C	107-111
19293600-4	2009	RESULTS: Inhibition of the phospholipase C (PLC) pathway blunted ANG II inhibitory effects on [(3)H]-DA uptake, since U-73122, 2-APB, TMB-8, chelerythrine and KN-93 (PLC, IP(3)-dependent Ca(2+) release channels, IP(3) receptors, protein kinase C and CaM kinase II inhibitors, respectively) each one blocked ANG II effects.	ip	171-173	angiotensinogen	Rattus norvegicus	65-71
18355727-3	2008	Inositol hexakisphosphate kinase (IP6K) is able to convert the natural substrates inositol pentakisphosphate (IP 5) and inositol hexakisphosphate (IP 6) to several products with an increasing number of phospho-anhydride bonds.	ip	110-112	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	34-38
18474671-11	2008	These results indicate that exogenous chitinase is a potent proteolytic activator of PAR-2 that can directly induce PLC/IP(3)-dependent Ca(2+) signaling in human airway epithelial cells.	ip	120-122	F2R like trypsin receptor 1	Homo sapiens	85-90
18724935-3	2008	Gle1 is an essential, conserved mRNA export factor whose export function is dependent on the small molecule inositol hexakisphosphate (IP(6)).	ip	135-137	nucleoporin GLE1	Saccharomyces cerevisiae S288C	0-4
18378772-3	2008	Under conditions of low PLA(2) activation, both also use extracellular ATP-mediated activation of phospholipase C (PLC)-inositol trisphosphate (IP(3)) signaling to support TRPV4 gating.	ip	144-146	phospholipase A2 group IB	Homo sapiens	24-30
18378772-3	2008	Under conditions of low PLA(2) activation, both also use extracellular ATP-mediated activation of phospholipase C (PLC)-inositol trisphosphate (IP(3)) signaling to support TRPV4 gating.	ip	144-146	transient receptor potential cation channel subfamily V member 4	Homo sapiens	172-177
18355727-4	2008	In this study, we structurally analyzed IPs synthesized by three mammalian isoforms of IP6K from IP 5 and IP 6.	ip	40-42	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	87-91
18537667-7	2008	The actions of these COX-2 metabolites are likely mediated by mitogen-activated protein kinase (MAPK) and inositol 1,4,5-trisphosphate (IP(3)) signal transduction pathways.	ip	136-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	21-26
19109659-1	2008	Fatty acids of trans configuration in our food come from two different sources - industrially produced partially hydrogenated fat (IP-TFA) used in frying oils, margarines, spreads, and in bakery products, and ruminant fat in dairy and meat products (RP-TFA).	ip	131-133	coagulation factor III, tissue factor	Homo sapiens	134-137
18078445-7	2008	A third system, the IP(3)-pathway, is mediated by G(q)-proteins, phospholipase C and IP(3), which mobilize Ca(2+) from intracellular stores, with a resultant increase in insulin.	ip	20-22	insulin	Homo sapiens	170-177
18434237-11	2008	Enhanced expression of ARHGAP6 was associated with an elevated level of PLC activity and increased levels of IP(3) (1.6-fold) and DAG (2.3-fold).	ip	109-111	Rho GTPase activating protein 6	Homo sapiens	23-30
17728398-1	2007	Airway goblet cell mucin secretion is controlled by agonist activation of P2Y(2) purinoceptors, acting through Gq/PLC, inositol-1,4,5-trisphosphate (IP(3)), diacylglycerol, Ca(2+) and protein kinase C (PKC).	ip	149-151	solute carrier family 13 member 2	Rattus norvegicus	19-24
17728398-1	2007	Airway goblet cell mucin secretion is controlled by agonist activation of P2Y(2) purinoceptors, acting through Gq/PLC, inositol-1,4,5-trisphosphate (IP(3)), diacylglycerol, Ca(2+) and protein kinase C (PKC).	ip	149-151	protein kinase C, epsilon	Mus musculus	202-205
17934773-8	2007	Grm1 is responsible for the generation of inositol 1,4,5-trisphosphate (IP(3)).	ip	72-74	glutamate receptor, metabotropic 1	Mus musculus	0-4
17395626-5	2007	However, in sympathetic neurons, M-current inhibition by bradykinin appears to be mediated through the release and action of intracellular Ca(2)+ by inositol-1,4,5-trisphosphate (IP(3)), a product of PIP(2) hydrolysis, rather than by PIP(2) depletion.	ip	179-181	kininogen 1	Homo sapiens	57-67
17447081-3	2007	In sympathetic neurons, closure induced by stimulating M1-muscarinic acetylcholine receptors (mAChRs) has been attributed to depletion of PI(4,5)P(2), whereas closure by bradykinin B(2)-receptors (B2-BKRs) appears to result from formation of IP(3) and release of Ca(2+), implying that BKR stimulation does not deplete PI(4,5)P(2).	ip	242-244	kininogen 1	Homo sapiens	170-180
17595165-3	2007	Wnt3a triggers G-protein-linked phosphatidylinositol signaling, transiently generating inositol polyphosphates, especially inositol pentakisphosphate (IP(5)) accumulation.	ip	151-153	Wnt family member 3A	Rattus norvegicus	0-5
17595165-7	2007	Wnt3a stimulation of the canonical pathway requires accumulation of IP(5), which acts to inhibit the activity of glycogen synthase kinase-3beta, whereas stimulating casein kinase 2.	ip	68-70	Wnt family member 3A	Rattus norvegicus	0-5
17595165-7	2007	Wnt3a stimulation of the canonical pathway requires accumulation of IP(5), which acts to inhibit the activity of glycogen synthase kinase-3beta, whereas stimulating casein kinase 2.	ip	68-70	glycogen synthase kinase 3 beta	Rattus norvegicus	113-143
17404493-1	2007	The second messenger myo-inositol-1,4,5-trisphosphate (IP(3)) acts on the IP(3) receptor (IP(3)R), an IP(3)-activated Ca(2+) channel of the endoplasmic reticulum (ER).	ip	55-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-88
17404493-1	2007	The second messenger myo-inositol-1,4,5-trisphosphate (IP(3)) acts on the IP(3) receptor (IP(3)R), an IP(3)-activated Ca(2+) channel of the endoplasmic reticulum (ER).	ip	55-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-96
17289581-4	2007	In budding yeast, recent work suggests that the DEAD-box helicase Dbp5 remodels mRNPs at the NPC cytoplasmic face by removing Mex67 and that the Dbp5 ATPase is activated by Gle1 and inositol hexaphosphate (IP(6)).	ip	206-208	ATP-dependent RNA helicase DBP5	Saccharomyces cerevisiae S288C	66-70
17339845-8	2007	TNFalpha -induced enhancement of PAR2 stimulated [(3)H]-inositol phosphate accumulation (IP) and Ca(2+) signalling was abolished following SB203580 pre-treatment.	ip	89-91	tumor necrosis factor	Homo sapiens	0-8
17339845-8	2007	TNFalpha -induced enhancement of PAR2 stimulated [(3)H]-inositol phosphate accumulation (IP) and Ca(2+) signalling was abolished following SB203580 pre-treatment.	ip	89-91	F2R like trypsin receptor 1	Homo sapiens	33-37
17289581-4	2007	In budding yeast, recent work suggests that the DEAD-box helicase Dbp5 remodels mRNPs at the NPC cytoplasmic face by removing Mex67 and that the Dbp5 ATPase is activated by Gle1 and inositol hexaphosphate (IP(6)).	ip	206-208	ATP-dependent RNA helicase DBP5	Saccharomyces cerevisiae S288C	145-149
17289581-4	2007	In budding yeast, recent work suggests that the DEAD-box helicase Dbp5 remodels mRNPs at the NPC cytoplasmic face by removing Mex67 and that the Dbp5 ATPase is activated by Gle1 and inositol hexaphosphate (IP(6)).	ip	206-208	nucleoporin GLE1	Saccharomyces cerevisiae S288C	173-177
17144473-2	2006	METHOD: Rats were administered with CCl4 (ip) or alcohol (ig) to establish acute or chronic liver injured model, respectively.	ip	42-44	C-C motif chemokine ligand 4	Rattus norvegicus	36-40
17027490-5	2006	CCK and ACh recruit Ca(2+) from lysosomes and from zymogen granules through different mechanisms; CCK uses NAADP and cADPR, respectively, and ACh uses Ca(2+) and IP(3), respectively.	ip	162-164	cholecystokinin	Homo sapiens	0-3
17027490-5	2006	CCK and ACh recruit Ca(2+) from lysosomes and from zymogen granules through different mechanisms; CCK uses NAADP and cADPR, respectively, and ACh uses Ca(2+) and IP(3), respectively.	ip	162-164	cholecystokinin	Homo sapiens	98-101
16942748-6	2006	Blocking of the endogenous IP/Gs coupling by the minigene-expressed peptides of the Galphas CT, iLP1 and iLP3 was further observed in the human coronary artery smooth muscle cells (SMCs).	ip	27-29	X-linked inhibitor of apoptosis	Homo sapiens	96-100
16251482-6	2006	After being injected with cisplatin (ip, 45 mg/kg), mice drinking 2% acetone with increased CYP2E1 levels exhibited elevated levels of serum ALT and AST, liver caspase-3 activity and positive staining of TUNEL increased, and histopathology indicated the presence of necrotic foci in livers of acetone plus cisplatin-treated mice.	ip	37-39	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	92-98
16778372-12	2006	PAI-1 levels were lower in animals receiving IP pentoxifylline compared to control animals and those treated with IV pentoxifylline (p = 0.048, p = 0.015, respectively).	ip	45-47	serpin family E member 2	Rattus norvegicus	0-5
16777332-1	2006	LIBRA is a fluorescent biosensor of inositol 1,4,5-trisphosphate (IP(3)) and is composed of the ligand-binding domain of the rat type 3 IP(3) receptor and cyan and yellow fluorescent proteins.	ip	66-68	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	136-150
16439357-3	2006	Here we characterize the structural, molecular, and cellular interactions between arrestin-2 and inositol hexakisphosphate (inositol 1,2,3,4,5,6-hexakisphosphate (IP(6))).	ip	163-165	arrestin beta 1	Homo sapiens	82-92
16251482-6	2006	After being injected with cisplatin (ip, 45 mg/kg), mice drinking 2% acetone with increased CYP2E1 levels exhibited elevated levels of serum ALT and AST, liver caspase-3 activity and positive staining of TUNEL increased, and histopathology indicated the presence of necrotic foci in livers of acetone plus cisplatin-treated mice.	ip	37-39	glutamic pyruvic transaminase, soluble	Mus musculus	141-144
16251482-6	2006	After being injected with cisplatin (ip, 45 mg/kg), mice drinking 2% acetone with increased CYP2E1 levels exhibited elevated levels of serum ALT and AST, liver caspase-3 activity and positive staining of TUNEL increased, and histopathology indicated the presence of necrotic foci in livers of acetone plus cisplatin-treated mice.	ip	37-39	transmembrane protease, serine 11d	Mus musculus	149-152
16251482-6	2006	After being injected with cisplatin (ip, 45 mg/kg), mice drinking 2% acetone with increased CYP2E1 levels exhibited elevated levels of serum ALT and AST, liver caspase-3 activity and positive staining of TUNEL increased, and histopathology indicated the presence of necrotic foci in livers of acetone plus cisplatin-treated mice.	ip	37-39	caspase 3	Mus musculus	160-169
16204795-4	2005	Moreover, TMB-8 (10 microM), an antagonist of inositol 1, 4, 5 trisphosphate (IP(3)) receptor prevented the activation of PARP-1, which indicates that IP(3) /Ca(2+) signaling is involved in this pathway.	ip	78-80	poly (ADP-ribose) polymerase 1	Rattus norvegicus	122-128
15591586-3	2005	Motilin selectively activated G(q) and G(13), stimulated G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca(2+) release, and increased cytosolic free Ca(2+).	ip	136-138	motilin	Homo sapiens	0-7
15911776-5	2005	Here, we use the expression of IP(3) binding protein domains tethered to the surface of the endoplasmic reticulum (ER) to show that the all-helical domain of the IP(3)R LBD is capable of depleting the ER Ca(2+) pools by opening the endogenous IP(3)Rs, even without IP(3) binding.	ip	31-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	162-168
15582487-2	2005	This in turn leads to the generation of second messengers like Ca(2+), diacylglycerol (DAG) and inositoltrisphosphate (IP(3)) as well as the activation of effector molecules like Ras and the mitogen-activated protein kinases (MAPKs) and ultimately in activation of the transcription factors NFAT, AP-1, and NF-kappaB, resulting in gene transcription.	ip	119-121	nuclear factor kappa B subunit 1	Homo sapiens	307-316
15194051-4	2004	To clarify this issue, we created expression constructs for mutants of IP-10 that exhibit partial (IP-10C) or total (IP-10C22) loss of binding to CXCR3 or loss of binding to glycosaminoglycans (IP-10H and IP-10C22H).	ip	71-73	C-X-C motif chemokine receptor 3	Homo sapiens	146-151
15199065-5	2004	However, the second LP is changed to isoleucylprolyl (IP) in TRPC1, -C4, and -C5, and valylprolyl (VP) in TRPC3, -C6, and -C7.	ip	54-56	transient receptor potential cation channel subfamily C member 1	Homo sapiens	61-66
15183126-7	2004	Analysis by native gel electrophoresis confirmed that the step inhibited in the autoactivation process was the transition between the 0P and IP forms of IGF1R.	ip	141-143	insulin-like growth factor 1 receptor	Cricetulus griseus	153-158
16035968-2	2005	A 2 Mbit/s ATM network was employed for IP-based videoconferencing.	ip	40-42	ATM serine/threonine kinase	Homo sapiens	11-14
15194051-4	2004	To clarify this issue, we created expression constructs for mutants of IP-10 that exhibit partial (IP-10C) or total (IP-10C22) loss of binding to CXCR3 or loss of binding to glycosaminoglycans (IP-10H and IP-10C22H).	ip	99-101	C-X-C motif chemokine ligand 10	Homo sapiens	71-76
15038602-5	2004	Different mutations were found in the nuclear NDUFS4 gene coding for the 18 kD (IP, AQDQ) subunit of complex I.	ip	80-82	NADH:ubiquinone oxidoreductase subunit S4	Homo sapiens	46-52
15093681-2	2004	Inositol 1,4,5-trisphosphate 3-kinase A (IP(3)K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP(3)) to inositol 1,3,4,5-tetrakisphosphate (IP(4)).	ip	183-185	inositol-trisphosphate 3-kinase A	Rattus norvegicus	0-49
14966570-4	2004	Indeed, we found that HDL and APOE suppress aortic smooth muscle cell cycle progression by stimulating Cox-2 expression, leading to prostacyclin synthesis and an IP-dependent inhibition of the cyclin A gene.	ip	162-164	apolipoprotein E	Mus musculus	30-34
14660553-10	2004	Genistein treatment largely decreased the IGF-1-induced changes in both Ca(2+)(i) and IP(3).	ip	86-88	insulin-like growth factor 1	Rattus norvegicus	42-47
14618376-4	2004	Inositol triphosphate (IP(3)) in yeast is rapidly transformed into IP(4) and IP(5) by a dual kinase, Arg82.	ip	23-25	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	101-106
14618376-4	2004	Inositol triphosphate (IP(3)) in yeast is rapidly transformed into IP(4) and IP(5) by a dual kinase, Arg82.	ip	67-69	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	101-106
14618376-8	2004	These results taken together suggest that Plc1p activation by glucose, leading to cleavage of PIP(2) and generation of IP(3), seems to be sufficient for raising the calcium level in the cytosol.	ip	95-97	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	42-47
14966570-4	2004	Indeed, we found that HDL and APOE suppress aortic smooth muscle cell cycle progression by stimulating Cox-2 expression, leading to prostacyclin synthesis and an IP-dependent inhibition of the cyclin A gene.	ip	162-164	cyclin A2	Mus musculus	193-201
12410638-4	2003	Furthermore, inhibition of Ins(1,4,5) P (3) (IP(3)) receptors with xestospongin C, or application of ryanodine, partially inhibited GLP-1-induced [ATP](m) increases, and the simultaneous blockade of both IP(3) and ryanodine receptors (RyR) completely eliminated the rise in [ATP](m).	ip	45-47	glucagon	Mus musculus	132-137
12566360-5	2003	At the end of the study, LDLR KO on a vitamin E-supplemented fat diet had decreased 8,12-iso-isoprostane (iP)F(2alpha)-VI and monocyte chemoattractant protein-1 levels, but increased nitric oxide levels compared with mice on placebo.	ip	106-108	low density lipoprotein receptor	Mus musculus	25-29
12843957-5	2003	In order to assess the health hazard of active recovery of these resting cells, we studied biofilms with two fluorochromes: a fluorescein diacetate derivative, CDF, which detects esterase activity and gives a green fluorescence to cells, and propidium iodide, IP, which enters cells with injured membranes and gives a red fluorescence to nucleic acids.	ip	260-262	LIF interleukin 6 family cytokine	Homo sapiens	160-163
12618215-2	2003	The alpha(1A)-selective agonist A61603 was as effective as noradrenaline in eliciting 3H-inositol phosphate (IP) accumulation but was approximately 50-fold more potent.	ip	109-111	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	4-12
12581861-13	2003	Taken together, these results suggest that PTH regulation of enterocyte [Ca(2+)](i) involves Ca(2+) mobilization from IP(3)-sensitive stores and the influx of the cation from the extracellular milieu, the former pathway being blunted during ageing.	ip	118-120	parathyroid hormone	Rattus norvegicus	43-46
12410638-4	2003	Furthermore, inhibition of Ins(1,4,5) P (3) (IP(3)) receptors with xestospongin C, or application of ryanodine, partially inhibited GLP-1-induced [ATP](m) increases, and the simultaneous blockade of both IP(3) and ryanodine receptors (RyR) completely eliminated the rise in [ATP](m).	ip	45-47	ryanodine receptor 1, skeletal muscle	Mus musculus	214-233
12410638-4	2003	Furthermore, inhibition of Ins(1,4,5) P (3) (IP(3)) receptors with xestospongin C, or application of ryanodine, partially inhibited GLP-1-induced [ATP](m) increases, and the simultaneous blockade of both IP(3) and ryanodine receptors (RyR) completely eliminated the rise in [ATP](m).	ip	45-47	ryanodine receptor 1, skeletal muscle	Mus musculus	235-238
12226109-2	2002	In budding yeast, IP(6) synthesis occurs through the sequential phosphorylation of I(1,4,5)P(3) by two gene products, Ipk2 and Ipk1, a IP(3)/IP(4) dual-specificity 6-/3-kinase and an inositol 1,3,4,5,6-pentakisphosphate 2-kinase, respectively.	ip	18-20	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	118-122
12226109-2	2002	In budding yeast, IP(6) synthesis occurs through the sequential phosphorylation of I(1,4,5)P(3) by two gene products, Ipk2 and Ipk1, a IP(3)/IP(4) dual-specificity 6-/3-kinase and an inositol 1,3,4,5,6-pentakisphosphate 2-kinase, respectively.	ip	18-20	inositol pentakisphosphate 2-kinase	Saccharomyces cerevisiae S288C	127-131
12226109-2	2002	In budding yeast, IP(6) synthesis occurs through the sequential phosphorylation of I(1,4,5)P(3) by two gene products, Ipk2 and Ipk1, a IP(3)/IP(4) dual-specificity 6-/3-kinase and an inositol 1,3,4,5,6-pentakisphosphate 2-kinase, respectively.	ip	135-137	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	118-122
12226109-2	2002	In budding yeast, IP(6) synthesis occurs through the sequential phosphorylation of I(1,4,5)P(3) by two gene products, Ipk2 and Ipk1, a IP(3)/IP(4) dual-specificity 6-/3-kinase and an inositol 1,3,4,5,6-pentakisphosphate 2-kinase, respectively.	ip	135-137	inositol pentakisphosphate 2-kinase	Saccharomyces cerevisiae S288C	127-131
12226109-7	2002	Additionally, we report that the plant and yeast Ipk2 have a novel 5-kinase activity toward I(1,3,4,6)P(4) and I(1,2,3,4,6)P(5), which would allow these proteins to participate in at least two proposed pathways in the synthesis of IP(6).	ip	231-233	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	49-53
12226109-8	2002	Heterologous expression of either plant isoform in an ipk2 mutant yeast strain restores IP(4) and IP(5) production in vivo and rescues its temperature-sensitive growth defects.	ip	88-90	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	54-58
12226109-8	2002	Heterologous expression of either plant isoform in an ipk2 mutant yeast strain restores IP(4) and IP(5) production in vivo and rescues its temperature-sensitive growth defects.	ip	98-100	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	54-58
11907035-6	2002	In cells pretreated with to inhibit phospholipase C activation and to block the degradation of PI 4,5-bisphosphate to form [(3)H]inositol trisphosphate (IP(3)), CaR stimulated the accumulation of [(3)H]PI monophosphate (PIP).	ip	153-155	prolactin induced protein	Homo sapiens	220-223
12171651-7	2002	The fry1 plants showed enhanced induction of stress genes in response to cold, ABA, salt and dehydration due to higher accumulation of the second messenger, inositol (1,4,5)- triphosphate (IP(3)).	ip	189-191	SAL1 phosphatase-like protein	Arabidopsis thaliana	4-8
12237343-8	2002	For P2 receptor antagonists, the potency order at rP2X(5) was pyridoxal-5-phosphate-6-azophenyl-2",4"-disulfonic acid (PPADS) > 2",3"-O-(2,4,6-trinitrophenyl)ATP (TNP-ATP) > suramin > reactive blue 2 (RB-2) > diinosine pentaphosphate (Ip(5)I).	ip	247-249	purinergic receptor P2X 5	Rattus norvegicus	50-57
12123527-9	2002	CONCLUSIONS: Opening of mitoK(ATP) channels and activation of PKC and p38MAPK are obligatory steps in the signal transduction cascade of IP and PP of the human myocardium with PKC activation being downstream of the opening of mitoK(ATP) channels and upstream of p38MAPK activation.	ip	137-139	proline rich transmembrane protein 2	Homo sapiens	62-65
12123527-9	2002	CONCLUSIONS: Opening of mitoK(ATP) channels and activation of PKC and p38MAPK are obligatory steps in the signal transduction cascade of IP and PP of the human myocardium with PKC activation being downstream of the opening of mitoK(ATP) channels and upstream of p38MAPK activation.	ip	137-139	proline rich transmembrane protein 2	Homo sapiens	176-179
11943493-1	2002	In our study, we observed the activation of in vitro matured pig oocytes and their subsequent parthenogenetic cleavage after stimulation of ryanodine receptors (RyR) using ryanodine (Ry), caffeine or cyclic adenosine diphosphate ribose (cADPri) or after stimulation of inositol triphosphate receptors (IP(3)R) using D-myo-inositol 1,4,5-triphosphate (IP(3)).	ip	302-304	ryanodine receptor 1	Sus scrofa	140-159
11943493-1	2002	In our study, we observed the activation of in vitro matured pig oocytes and their subsequent parthenogenetic cleavage after stimulation of ryanodine receptors (RyR) using ryanodine (Ry), caffeine or cyclic adenosine diphosphate ribose (cADPri) or after stimulation of inositol triphosphate receptors (IP(3)R) using D-myo-inositol 1,4,5-triphosphate (IP(3)).	ip	302-304	ryanodine receptor 1	Sus scrofa	161-164
11823449-7	2002	In addition, in HEK 293 cells expressing the human LHR, V-LH demonstrated 1.8-fold higher response of inositol trisphosphate (IP(3)) production than WT-LH.	ip	126-128	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	51-54
11956293-2	2002	Here we show that calcium/calcineurin-dependent activation of nuclear factor of activated T cells (NFAT) by Nef in Jurkat T cells requires the endoplasmic reticulum-resident inositol trisphosphate receptor (IP(3)R), but yet does not involve increase in phospholipase-C gamma 1 (PLC gamma 1)-catalyzed production of IP(3) or depletion of IP(3)-regulated intracellular calcium stores.	ip	207-209	S100 calcium binding protein B	Homo sapiens	108-111
11956293-2	2002	Here we show that calcium/calcineurin-dependent activation of nuclear factor of activated T cells (NFAT) by Nef in Jurkat T cells requires the endoplasmic reticulum-resident inositol trisphosphate receptor (IP(3)R), but yet does not involve increase in phospholipase-C gamma 1 (PLC gamma 1)-catalyzed production of IP(3) or depletion of IP(3)-regulated intracellular calcium stores.	ip	207-209	phospholipase C gamma 1	Homo sapiens	253-276
11956293-2	2002	Here we show that calcium/calcineurin-dependent activation of nuclear factor of activated T cells (NFAT) by Nef in Jurkat T cells requires the endoplasmic reticulum-resident inositol trisphosphate receptor (IP(3)R), but yet does not involve increase in phospholipase-C gamma 1 (PLC gamma 1)-catalyzed production of IP(3) or depletion of IP(3)-regulated intracellular calcium stores.	ip	207-209	phospholipase C gamma 1	Homo sapiens	278-289
11741947-11	2002	We confirmed that the BDNF-induced glutamate release occurred through a glutamate transporter that was dependent on the PLC-gamma/IP(3)/Ca(2+) pathway.	ip	130-132	brain-derived neurotrophic factor	Rattus norvegicus	22-26
11485991-7	2001	Map-based cloning revealed that FRY1 encodes an inositol polyphosphate 1-phosphatase, which functions in the catabolism of inositol 1, 4, 5-trisphosphate (IP(3)).	ip	155-157	SAL1 phosphatase-like protein	Arabidopsis thaliana	32-36
11563852-3	2001	Because AngII is known to act in the anterior pituitary through the phosphatidiloinositol breakdown, thus increasing the level of inositol-1,4,5-trisphosphate (IP(3)), the IP(3) concentration was determined 24 h after the injection in the anterior pituitary homogenate after in vitro exposure to AngII.	ip	160-162	angiotensinogen	Rattus norvegicus	8-13
21340820-9	2001	Phosphatidylinositol-specific phospholipase C(PI-PLC) is the rate-limiting enzyme of PI turnover (1), and catalyzes the hydrolysis of PI-4,5-P(2) to produce two second messengers, inositol 1,4,5-trisphosphate (IP(3)) and DAG.	ip	210-212	phospholipase C beta 1	Homo sapiens	46-52
11350513-7	2001	RESULTS: In the EOP-group 27.8% were IL-4 promotor- and intron polymorphism positive (PP+ and IP+).	ip	94-96	interleukin 4	Homo sapiens	37-41
11245589-3	2001	Additionally, a taste-enriched G protein gamma-subunit, Ggamma(13), colocalizes with Galpha(gust) and mediates the denatonium-stimulated production of inositol 1,4,5-trisphosphate (IP(3)).	ip	181-183	glucuronidase, beta	Mus musculus	92-96
11257458-1	2001	We previously reported that in rat duodenal cells (enterocytes), parathyroid hormone (PTH [1-34]: PTH) stimulates the hydrolysis of polyphosphoinositides by phospholipase C (PLC), generating the second messengers inositol trisphosphate (IP(3)) and diacylglycerol (DAG) and that this mechanism is severely altered in old animals.	ip	237-239	parathyroid hormone	Rattus norvegicus	86-89
11257458-1	2001	We previously reported that in rat duodenal cells (enterocytes), parathyroid hormone (PTH [1-34]: PTH) stimulates the hydrolysis of polyphosphoinositides by phospholipase C (PLC), generating the second messengers inositol trisphosphate (IP(3)) and diacylglycerol (DAG) and that this mechanism is severely altered in old animals.	ip	237-239	parathyroid hormone	Rattus norvegicus	98-101
11287327-4	2001	The phospholipase C inhibitor U-73122 and the inositol trisphosphate (IP(3)) receptor inhibitor xestospongin C both inhibited endostatin-induced elevation in [Ca(2+)](i), and endostatin rapidly elevated endothelial cell IP(3) levels.	ip	70-72	collagen, type XVIII, alpha 1	Mus musculus	126-136
11157673-2	2001	In A7r5 cells, we confirmed that inositol 1,4,5-trisphosphate (IP(3)) mediates vasopressin (VP)-evoked Ca(2+) release from intracellular stores and showed that types 1 (IP(3)R(1)) and 3 (IP(3)R(3)) IP(3) receptors were expressed.	ip	63-65	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	160-185
11157673-2	2001	In A7r5 cells, we confirmed that inositol 1,4,5-trisphosphate (IP(3)) mediates vasopressin (VP)-evoked Ca(2+) release from intracellular stores and showed that types 1 (IP(3)R(1)) and 3 (IP(3)R(3)) IP(3) receptors were expressed.	ip	63-65	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	187-196
10771086-3	2000	Both TPalpha and TPbeta couple similarly to Galpha(16) to affect increases in inositol 1,4,5-trisphosphate (IP(3)) and mobilisation of intracellular calcium ([Ca(2+)](i)) in response to the TP agonist U46619.	ip	108-110	G protein subunit alpha 15	Homo sapiens	44-54
10906121-1	2000	Given the interaction of the inositol 1,4,5-trisphosphate receptor (IP(3)R) with chromogranins A (CGA) and B (CGB), two major Ca(2+) storage proteins of secretory granules that have been shown to be IP(3)-sensitive intracellular Ca(2+) store of neuroendocrine cells, we have investigated the potential interaction of the intraluminal loop regions of the IP(3)R with both intact CGB and the conserved near N-terminal region of CGB.	ip	68-70	chromogranin A	Bos taurus	81-108
10906121-1	2000	Given the interaction of the inositol 1,4,5-trisphosphate receptor (IP(3)R) with chromogranins A (CGA) and B (CGB), two major Ca(2+) storage proteins of secretory granules that have been shown to be IP(3)-sensitive intracellular Ca(2+) store of neuroendocrine cells, we have investigated the potential interaction of the intraluminal loop regions of the IP(3)R with both intact CGB and the conserved near N-terminal region of CGB.	ip	68-70	chromogranin B	Bos taurus	110-113
10906121-1	2000	Given the interaction of the inositol 1,4,5-trisphosphate receptor (IP(3)R) with chromogranins A (CGA) and B (CGB), two major Ca(2+) storage proteins of secretory granules that have been shown to be IP(3)-sensitive intracellular Ca(2+) store of neuroendocrine cells, we have investigated the potential interaction of the intraluminal loop regions of the IP(3)R with both intact CGB and the conserved near N-terminal region of CGB.	ip	68-70	chromogranin B	Bos taurus	378-381
10906121-1	2000	Given the interaction of the inositol 1,4,5-trisphosphate receptor (IP(3)R) with chromogranins A (CGA) and B (CGB), two major Ca(2+) storage proteins of secretory granules that have been shown to be IP(3)-sensitive intracellular Ca(2+) store of neuroendocrine cells, we have investigated the potential interaction of the intraluminal loop regions of the IP(3)R with both intact CGB and the conserved near N-terminal region of CGB.	ip	68-70	chromogranin B	Bos taurus	378-381
11179605-4	2001	In contrast, the inhibitor of phospholipase C (PLC) U-73122 abrogated, and the inhibitors of PKC, phosphatidylinositol trisphosphate (IP(3))-kinase and calmodulin (calphostin-C, wortmannin and W-7, respectively) partially prevented aldosterone response to BQ-3020.	ip	134-136	calmodulin 1	Rattus norvegicus	152-162
11007893-11	2000	Thus, among the many signal transduction pathways coupled to the PAC(1) receptor, the PACAP-induced depolarization of sympathetic neurons appears to require activation of PLC and subsequent generation of IP(3).	ip	204-206	adenylate cyclase activating polypeptide 1	Rattus norvegicus	86-91
10944431-1	2000	Angiotensin II (AngII) is known to act in the anteriorpituitary through phosphatidiloinositol breakdown, increasing the level of inositol-1,4,5-trisphosphate (IP(3)) and diacyloglycerol (DAG), a potential activator of protein kinase C (PKC).	ip	159-161	angiotensinogen	Rattus norvegicus	0-14
10944431-1	2000	Angiotensin II (AngII) is known to act in the anteriorpituitary through phosphatidiloinositol breakdown, increasing the level of inositol-1,4,5-trisphosphate (IP(3)) and diacyloglycerol (DAG), a potential activator of protein kinase C (PKC).	ip	159-161	angiotensinogen	Rattus norvegicus	16-21
10836991-5	2000	Functional effects of TGF-beta1-induced downregulation of the IP(3)Rs were evaluated by measuring [Ca(2+)](c) changes in response to epidermal growth factor (EGF) in intact cells and sensitivity of [Ca(2+)](c) release to IP(3) in permeabilized cells.	ip	62-64	transforming growth factor beta 1	Homo sapiens	22-31
10836991-5	2000	Functional effects of TGF-beta1-induced downregulation of the IP(3)Rs were evaluated by measuring [Ca(2+)](c) changes in response to epidermal growth factor (EGF) in intact cells and sensitivity of [Ca(2+)](c) release to IP(3) in permeabilized cells.	ip	62-64	epidermal growth factor	Homo sapiens	158-161
10854619-4	2000	Under basal conditions, ET-1 and ET-3 (1.0 microM each) elevated tissue cyclic AMP (cAMP) levels nearly 3-fold (P<0.001, ET-1; P<0.05, ET-3) and inositol phosphate (IP(n)) levels nearly 4-fold (P<0.01, ET-1).	ip	171-173	endothelin-1	Oryctolagus cuniculus	24-37
10704748-6	2000	These results suggest that IL-1beta-induced responses in human microglia involve both a Ca(2+) entry pathway and a mechanism of intracellular increase other than from IP(3)-sensitive stores.	ip	167-169	interleukin 1 beta	Homo sapiens	27-35
10551852-2	1999	With [Ca(2+)](i) strongly buffered to 100 nM, I(crac) was activated by ionomycin, thapsigargin, inositol 1,4,5-trisphosphate (IP(3)), and two metabolically stable IP(3) receptor agonists, adenophostin A and L-alpha-glycerophospho-D-myoinositol-4,5-bisphosphate (GPIP(2)).	ip	126-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	163-177
10600161-8	1999	Antibody-induced increases in IP(3) and [Ca(2+)](i) in macrophages on ligation of LRP were pertussis toxin sensitive.	ip	30-32	LDL receptor related protein 1	Homo sapiens	82-85
10644473-8	2000	Cells exposed to 100 ng/ml EGF demonstrated an initial increase in [Ca(2+)](i) (1-5 min) which was blocked with neomycin, an inhibitor of inositol 1,4,5-trisphosphate (IP(3)) generation, and the phospholipase C (PLC) inhibitor U73122, but not U73343 (inactive control).	ip	168-170	epidermal growth factor	Homo sapiens	27-30
10694205-6	2000	Bradyzide inhibits bradykinin-induced [(3)H]-inositol trisphosphate (IP(3)) formation with IC(50) values of 11.6+/-1.4 nM (n=3) at the rat and 2.4+/-0.3 microM (n=3) at the human receptor.	ip	69-71	kininogen 1	Homo sapiens	19-29
10611423-5	1999	Similarly, in functional assays, irbesartan exhibited the highest functional potency to block angiotensin II-induced inositol trisphosphate (IP(3)) turnover.	ip	141-143	angiotensinogen	Rattus norvegicus	94-108
10521707-2	1999	Phospholipase C-gamma1 (PLC-gamma1) is a mediator of growth factor induced-signal cascade, catalyzing the hydrolysis of phosphatidyl 4,5-bisphosphate to generate second messengers, diacylglycerol and inositol 1,4,5-trisphosphate (IP(3)).	ip	230-232	phospholipase C, gamma 1	Rattus norvegicus	0-22
10521707-2	1999	Phospholipase C-gamma1 (PLC-gamma1) is a mediator of growth factor induced-signal cascade, catalyzing the hydrolysis of phosphatidyl 4,5-bisphosphate to generate second messengers, diacylglycerol and inositol 1,4,5-trisphosphate (IP(3)).	ip	230-232	phospholipase C, gamma 1	Rattus norvegicus	24-34
10379939-6	1999	ACTH administration resulted in higher plasma glucose (Glu) compared to a control, although only steers housed at -5 degrees C evidently showed lower plasma inorganic phosphorus (IP).	ip	179-181	proopiomelanocortin	Homo sapiens	0-4
9176147-5	1997	Incubation of permeabilized VSMC with anti-PLC-beta 1 or anti-Gq alpha antibodies inhibited ANG II-dependent inositol polyphosphate (IP) formation, while anti-PLC-gamma 1 antibodies did not inhibit ANG II-regulated IP formation.	ip	133-135	phospholipase C beta 1	Homo sapiens	43-53
23338219-7	1997	Signal transduction at CCK receptors is mediated via G(q) protein-related activation of phospholipase C and the formation of inositol 1,4,5-triphosphate (IP(3)) and 1,2-diacylglycerol (DAG).	ip	154-156	cholecystokinin	Homo sapiens	23-26
9313928-5	1997	The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP.	ip	8-10	prostaglandin D2 synthase (brain)	Mus musculus	136-140
9176147-5	1997	Incubation of permeabilized VSMC with anti-PLC-beta 1 or anti-Gq alpha antibodies inhibited ANG II-dependent inositol polyphosphate (IP) formation, while anti-PLC-gamma 1 antibodies did not inhibit ANG II-regulated IP formation.	ip	133-135	angiotensinogen	Homo sapiens	92-98
1429846-5	1992	This indicated that some of the IP2 and IP formed in these cells was produced from PIP2 but that some of these compounds might be formed from PIP or PI.	ip	32-34	prolactin induced protein	Rattus norvegicus	83-86
9043801-2	1997	We investigated the regulation of the atrial natriuretic peptide and brain natriuretic peptide genes in a rat model of myocardial infarction induced by isoproterenol (IP rat) and in a rat model of cardiac hypertrophy induced by aorto-caval shunt (AC shunt rat).	ip	167-169	natriuretic peptide A	Rattus norvegicus	38-64
9043801-2	1997	We investigated the regulation of the atrial natriuretic peptide and brain natriuretic peptide genes in a rat model of myocardial infarction induced by isoproterenol (IP rat) and in a rat model of cardiac hypertrophy induced by aorto-caval shunt (AC shunt rat).	ip	167-169	natriuretic peptide B	Rattus norvegicus	69-94
8587347-1	1995	In rat spinal cord slices, endothelin-1 (ET-1) and -3 (ET-3), sarafotoxin 6c (STX-6c), and the ETB receptor agonist IRL-1620 produced increases of [3H]inositol phosphate (IP) accumulation with the following rank order of potency: ET-1 > ET-3 >> STX-6c = IRL-1620.	ip	171-173	endothelin 1	Rattus norvegicus	27-39
8587347-1	1995	In rat spinal cord slices, endothelin-1 (ET-1) and -3 (ET-3), sarafotoxin 6c (STX-6c), and the ETB receptor agonist IRL-1620 produced increases of [3H]inositol phosphate (IP) accumulation with the following rank order of potency: ET-1 > ET-3 >> STX-6c = IRL-1620.	ip	171-173	endothelin 1	Rattus norvegicus	41-53
8587347-1	1995	In rat spinal cord slices, endothelin-1 (ET-1) and -3 (ET-3), sarafotoxin 6c (STX-6c), and the ETB receptor agonist IRL-1620 produced increases of [3H]inositol phosphate (IP) accumulation with the following rank order of potency: ET-1 > ET-3 >> STX-6c = IRL-1620.	ip	171-173	endothelin 3	Rattus norvegicus	55-59
8587347-1	1995	In rat spinal cord slices, endothelin-1 (ET-1) and -3 (ET-3), sarafotoxin 6c (STX-6c), and the ETB receptor agonist IRL-1620 produced increases of [3H]inositol phosphate (IP) accumulation with the following rank order of potency: ET-1 > ET-3 >> STX-6c = IRL-1620.	ip	171-173	endothelin receptor type B	Rattus norvegicus	95-98
8587347-1	1995	In rat spinal cord slices, endothelin-1 (ET-1) and -3 (ET-3), sarafotoxin 6c (STX-6c), and the ETB receptor agonist IRL-1620 produced increases of [3H]inositol phosphate (IP) accumulation with the following rank order of potency: ET-1 > ET-3 >> STX-6c = IRL-1620.	ip	171-173	endothelin 1	Rattus norvegicus	41-45
8898024-9	1996	In contrast to Hg2+, the inhibition of Ip by Cd2+ and Pb2+ was rapidly reversible upon washout.	ip	39-41	CD2 molecule	Homo sapiens	45-48
8760043-1	1996	Treatment of rabbits with angiotensin-converting enzyme (ACE)-inhibiting drugs increases Na(+)-K+ pump current (Ip) of isolated cardiac myocytes when intracellular Na+ is at near-physiological levels.	ip	112-114	angiotensin-converting enzyme	Oryctolagus cuniculus	57-60
7963586-2	1994	The phosphorothioate antisense oligodeoxynucleotide, IP-3082, specific for ICAM-1 mRNA inhibited ICAM-1, but not vascular cell adhesion molecule-1, mRNA induction and expression of ICAM-1 molecules by mouse endothelioma cells.	ip	53-55	intercellular adhesion molecule 1	Mus musculus	75-81
7963586-2	1994	The phosphorothioate antisense oligodeoxynucleotide, IP-3082, specific for ICAM-1 mRNA inhibited ICAM-1, but not vascular cell adhesion molecule-1, mRNA induction and expression of ICAM-1 molecules by mouse endothelioma cells.	ip	53-55	intercellular adhesion molecule 1	Mus musculus	97-103
7963586-2	1994	The phosphorothioate antisense oligodeoxynucleotide, IP-3082, specific for ICAM-1 mRNA inhibited ICAM-1, but not vascular cell adhesion molecule-1, mRNA induction and expression of ICAM-1 molecules by mouse endothelioma cells.	ip	53-55	vascular cell adhesion molecule 1	Mus musculus	113-146
7963586-2	1994	The phosphorothioate antisense oligodeoxynucleotide, IP-3082, specific for ICAM-1 mRNA inhibited ICAM-1, but not vascular cell adhesion molecule-1, mRNA induction and expression of ICAM-1 molecules by mouse endothelioma cells.	ip	53-55	intercellular adhesion molecule 1	Mus musculus	97-103
8065936-6	1994	IP 3196 inhibited PLA2 enzyme activity when the substrate was presented in the form of a phospholipid bilayer but not when presented in the form of a mixed micelle with anionic detergents.	ip	0-2	phospholipase A2 group IIA	Homo sapiens	18-22
8065936-7	1994	Human type II PLA2 was 50-fold more sensitive to inhibition by IP 3196 than venom and pancreatic type I enzymes.	ip	63-65	phospholipase A2 group IIA	Homo sapiens	14-18
1312133-2	1992	Endothelin-1 (ET) increased formation of 3H-inositol phosphate (IP) from PI and elicited an increase in cytosolic free Ca2+ ([Ca2+]i) in rat C6 glioma.	ip	64-66	endothelin 1	Rattus norvegicus	0-12
1312133-2	1992	Endothelin-1 (ET) increased formation of 3H-inositol phosphate (IP) from PI and elicited an increase in cytosolic free Ca2+ ([Ca2+]i) in rat C6 glioma.	ip	64-66	endothelin 1	Rattus norvegicus	14-16
1312133-6	1992	Both ET-mediated stimulation of IP formation and [Ca2+]i increase were largely inhibited in the absence of external Ca2+ but unaffected by the depletion of external Na+ and the presence of dihydropyridine derivatives or verapamil.	ip	32-34	endothelin 1	Rattus norvegicus	5-7
1648288-2	1991	complement factor C5a, leukotriene B4) to receptors of neutrophil granulocytes an activation of a GTP-binding protein is induced, that increases the activity of the phospholipase C in the membrane and thereby the liberation of inositol-1,4,5-phosphate (IP) and of diacylglycerol (DG).	ip	253-255	complement C5a receptor 1	Homo sapiens	18-21
1649746-5	1991	After CCK (10 micrograms/kg, ip), food intake increased from 28 +/- 5% of basal intake after a CSF icv to 48 +/- 8% after OVT icv (P less than 0.01); after HS (2 ml 2 M NaCl, ip), food intake increased from 9 +/- 4% of basal intake after aCSF icv to 43 +/- 7% after OVT icv (P less than 0.01); and after LiCl (1.125 mmol/kg, ip), food intake increased from 55 +/- 4% of basal intake after a CSF icv to 80 +/- 9% after OVT icv (P less than 0.01).	ip	29-31	cholecystokinin	Rattus norvegicus	6-9
34408810-6	2021	Therefore, our study sought to determine the role of inositol polyphosphate multikinase (IPMK), a key enzyme for IP metabolism and various cellular signaling control mechanisms, in mediating RA.	ip	113-115	inositol polyphosphate multikinase	Mus musculus	89-93
2153536-8	1990	In contrast, PT treatment of CCL39 hamster lung fibroblasts significantly blunted thrombin-stimulated [3H]IP accumulation and [3H]thymidine incorporation.	ip	106-108	coagulation factor II, thrombin	Homo sapiens	82-90
1987304-4	1991	Soluble mediators such as thrombin or histamine cause endothelial cell activation via a signal transduction mechanism that hydrolyzes phosphatidylinositol 4,5-bisphosphate (IP), liberating inositol trisphosphate (IP3).	ip	173-175	coagulation factor II, thrombin	Homo sapiens	26-34
34408810-6	2021	Therefore, our study sought to determine the role of inositol polyphosphate multikinase (IPMK), a key enzyme for IP metabolism and various cellular signaling control mechanisms, in mediating RA.	ip	113-115	inositol polyphosphate multikinase	Mus musculus	53-87
35551737-1	2022	Inositol polyphosphate multikinase (IPMK), a key enzyme in inositol polyphosphate (IP) metabolism, is a pleiotropic signaling factor involved in major biological events, including transcriptional control.	ip	83-85	inositol polyphosphate multikinase	Mus musculus	0-34
35551737-1	2022	Inositol polyphosphate multikinase (IPMK), a key enzyme in inositol polyphosphate (IP) metabolism, is a pleiotropic signaling factor involved in major biological events, including transcriptional control.	ip	83-85	inositol polyphosphate multikinase	Mus musculus	36-40
2473325-9	1989	EC-CM and ET-1 also resulted in time- and concentration-dependent increases in inositol monophosphate (IP) formation in rat aorta that paralleled the development of isometric force.	ip	103-105	endothelin 1	Rattus norvegicus	10-14
35456579-1	2022	Serum albumin binding moieties (ABMs) such as the Evans blue (EB) dye fragment and the 4-(p-iodophenyl)butyryl (IP) have been used to improve the pharmacokinetic profile of many radiopharmaceuticals.	ip	112-114	albumin	Homo sapiens	6-13
35052669-5	2022	We report that the T. brucei-derived ketoacids, indole pyruvate (IP) and hydroxyphenylpyruvate (HPP), induce HO-1 expression through Nrf2 activation in human dendritic cells (DC).	ip	65-67	heme oxygenase 1	Mus musculus	109-113
3023139-1	1986	Human chorionic gonadotropin, hCG, a hormone which increases intracellular cAMP, provoked rapid (30 s) and sustained (up to 30 min) increases in the levels of inositol mono-, bis- and trisphosphates (IP, IP2 and IP3, respectively) in bovine luteal cells.	ip	200-202	chorionic gonadotropin subunit beta 5	Homo sapiens	30-33
2855596-1	1988	Two chemically characterized peptides, arginine vasopressin (AVP) and corticotrophin-releasing factor-41 (CRF-41), known to stimulate ACTH secretion by interaction with their respective specific receptors on the corticotroph, were shown to cause the accumulation of phosphate esters of inositol (IP) and adenosine 3",5"-monophosphate (cAMP) respectively when added to rat anterior pituitary fragments incubated in vitro.	ip	296-298	arginine vasopressin	Rattus norvegicus	39-65
2901964-2	1988	Activation of human T lymphocytes via the CD2 molecule produces an enhanced turnover of phosphatidylinositol (PI) cycle-related phospholipids accompanied by the increased production of diacylglycerol (DG) and phosphorylated derivatives of inositol (IP).	ip	249-251	CD2 molecule	Homo sapiens	42-45
3661706-5	1987	Administration of proglumide (ip), a CCK receptor antagonist, during continuous CCK infusion significantly reduced immunoreactive CCK levels in PDS to 2% of the control group (P less than or equal to 0.01).	ip	30-32	cholecystokinin	Rattus norvegicus	37-40
3661706-5	1987	Administration of proglumide (ip), a CCK receptor antagonist, during continuous CCK infusion significantly reduced immunoreactive CCK levels in PDS to 2% of the control group (P less than or equal to 0.01).	ip	30-32	cholecystokinin	Rattus norvegicus	80-83
3661706-5	1987	Administration of proglumide (ip), a CCK receptor antagonist, during continuous CCK infusion significantly reduced immunoreactive CCK levels in PDS to 2% of the control group (P less than or equal to 0.01).	ip	30-32	cholecystokinin	Rattus norvegicus	80-83
3036249-3	1987	[3H]Inositol-labelled rabbit platelets were challenged with thrombin and/or AGEPC under a variety of protocols, and the phospholipase C mediated production of radioactive inositol monophosphate (IP); inositol bisphosphate (IP2) and inositol trisphosphate (IP3) was used as the parameter.	ip	195-197	LOC100009319	Oryctolagus cuniculus	120-135
3761308-5	1986	However, the very interesting observation was made that, when inhibiting COMT by means of tropolone and subsequently treating the rats with high doses of (S)-(-)-3-PPP (ip), postsynaptic dopaminergic activity was elicited.	ip	169-171	catechol-O-methyltransferase	Rattus norvegicus	73-77
3015563-2	1986	In the present study, we demonstrate that vasopressin (VP) stimulates the formation of inositol monophosphate (IP), inositol diphosphate (IP2) and inositol triphosphate (IP3) in primary cultures of glomerulosa as well as fasciculata cells 5- to 8-fold over the corresponding basal values.	ip	111-113	arginine vasopressin	Homo sapiens	42-53
3015563-2	1986	In the present study, we demonstrate that vasopressin (VP) stimulates the formation of inositol monophosphate (IP), inositol diphosphate (IP2) and inositol triphosphate (IP3) in primary cultures of glomerulosa as well as fasciculata cells 5- to 8-fold over the corresponding basal values.	ip	111-113	arginine vasopressin	Homo sapiens	55-57
819277-1	1976	Thyrotropin-releasing hormone (TRH) injected either IP (10 mg/kg) or intraventricularly (10 mug/rat) antagonized the pentobarbital-induced secretion of prolactin (PRL).	ip	52-54	thyrotropin releasing hormone	Rattus norvegicus	0-29
2983160-1	1985	CCK-octapeptide (CCK-8) (EC50 = 0.5 nM), in the presence of Li+, increased 3H-inositol phosphate (IP) accumulation in guinea pig gastric glands prelabeled with 3H-inositol.	ip	98-100	cholecystokinin	Cavia porcellus	0-3
2983160-1	1985	CCK-octapeptide (CCK-8) (EC50 = 0.5 nM), in the presence of Li+, increased 3H-inositol phosphate (IP) accumulation in guinea pig gastric glands prelabeled with 3H-inositol.	ip	98-100	cholecystokinin	Cavia porcellus	17-20
6386811-2	1984	Thrombin treatment caused rapid formation of radioactive inositol monophosphate (IP), inositol bisphosphate (IP2), and inositol trisphosphate (IP3) with less marked and more variable changes in the levels of radioactive inositol phospholipids.	ip	81-83	coagulation factor II, thrombin	Homo sapiens	0-8
6386811-3	1984	Formation of IP2 and IP3 could be detected 5 s after exposure to thrombin and before IP levels increased.	ip	13-15	coagulation factor II, thrombin	Homo sapiens	65-73
6386811-4	1984	Low doses of thrombin which produced only shape change in human platelets also caused significant formation of IP2 and IP3 but not IP.	ip	111-113	coagulation factor II, thrombin	Homo sapiens	13-21
6993364-4	1980	In contrast, mice prepared with IP oleic acid were killed with 10(4) CFU of GBS-III-SS620/50 IP.	ip	32-34	guanine nucleotide binding protein (G protein), beta 5	Mus musculus	76-79
3090472-2	1986	When [3H]inositol-prelabelled rat anterior hemipituitaries were incubated with AII (10 microM) for 30 min in the presence of Li+ (10 mM), the production of IP, IP2 and IP3 were increased to 182, 199 and 158% of paired control values.	ip	156-158	angiotensinogen	Rattus norvegicus	79-82
2992504-1	1985	A 2-min addition of LHRH to [3H]inositol-prelabeled rat granulosa cells in primary culture evoked significant increases in the accumulation of [3H]inositol phosphates, i.e. radiolabeled inositol monophosphate (IP), inositol diphosphate (IP2), and inositol triphosphate (IP3) levels increased to 210, 590 and 520%, respectively, when compared to control cultures.	ip	210-212	gonadotropin releasing hormone 1	Rattus norvegicus	20-24
6539286-1	1984	Administration of caffeine, ip 100 mg/kg/day for 1-5 days, to adult male rats resulted in a significant increase in hepatic cytochrome P-450 and b5 concentrations and in cytochrome c reductase, aminopyrine N-demethylase and acetanilide hydroxylase activities.	ip	28-30	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	124-147
6775933-5	1980	In a second group of rats, with or without median eminence destruction, the effects of different doses of ip dopamine on serum PRL were determined.	ip	106-108	prolactin	Rattus norvegicus	127-130
819277-1	1976	Thyrotropin-releasing hormone (TRH) injected either IP (10 mg/kg) or intraventricularly (10 mug/rat) antagonized the pentobarbital-induced secretion of prolactin (PRL).	ip	52-54	prolactin	Rattus norvegicus	152-161
33065792-10	2020	Also, we detected the mRNA and protein expression of BDNF, and 2% IP significantly increased the expression of BDNF.	ip	66-68	brain-derived neurotrophic factor	Rattus norvegicus	111-115
33103448-6	2021	A CRHP diet reduced postprandial glucose area under curve (net AUC) by 60% (P < 0.001), 24 h glucose by 13% (P < 0.001), fasting IP and SP concentrations (both absolute and relative to C-peptide, P < 0.05), and postprandial ISR (24%, P = 0.015), while IGI and Bup improved by 31% and 45% (both P < 0.001).	ip	129-131	cysteine rich protein 1	Homo sapiens	2-6
32393577-4	2020	Here, we found that cross-talk between SLC20A2 and XPR1 regulates phosphate homeostasis and identify XPR1 as a key inositol polyphosphate (IP)-dependent regulator of this process.	ip	139-141	solute carrier family 20 member 2	Homo sapiens	39-46
32634320-4	2020	The aim of the present study was to test the hypothesis that inositol polyphosphate multikinase (IPMK), a key enzyme in the IP metabolism, plays a critical role in adipose tissue biology and obesity.	ip	97-99	inositol polyphosphate multikinase	Mus musculus	61-95
32393577-4	2020	Here, we found that cross-talk between SLC20A2 and XPR1 regulates phosphate homeostasis and identify XPR1 as a key inositol polyphosphate (IP)-dependent regulator of this process.	ip	139-141	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	101-105
31286109-7	2019	Additionally, both OXT (IP) and OXTGly (IP) stimulated insulin, glucagon-like peptide 1, and glucagon secretion in mice.	ip	24-26	oxytocin	Mus musculus	19-22
30134819-11	2018	NRG-1 heart protein levels were upregulated in the IP group.	ip	51-53	neuregulin 1	Rattus norvegicus	0-5
29457462-6	2018	For EGFR (S1166) and AHNAK (S5480) a statistical significant change in the percentage of phosphorylation could be observed as a result of serum deprivation; for EGFR (S1166) this change was observed for both TiO2-PRM and IP-PRM.	ip	221-223	AHNAK nucleoprotein	Homo sapiens	21-26
29457462-6	2018	For EGFR (S1166) and AHNAK (S5480) a statistical significant change in the percentage of phosphorylation could be observed as a result of serum deprivation; for EGFR (S1166) this change was observed for both TiO2-PRM and IP-PRM.	ip	221-223	epidermal growth factor receptor	Homo sapiens	161-165
29292033-0	2018	Iloprost, a prostacyclin analog, inhibits the invasion of ovarian cancer cells by downregulating matrix metallopeptidase-2 (MMP-2) through the IP-dependent pathway.	ip	143-145	matrix metallopeptidase 2	Homo sapiens	97-122
29448093-3	2018	Mean exposure to HCA2 (PhIP + MeIQx), was 565.3 ng/day (95% CrI: 403.73, 726.88), and to PAH8 (sum of BaP, ChY, BaA, BkF, BbF, DahA, IP, and BghiP), was 634.8 ng/day (568.38, 701.15).	ip	25-27	MAGE family member C3	Homo sapiens	17-21
29292033-0	2018	Iloprost, a prostacyclin analog, inhibits the invasion of ovarian cancer cells by downregulating matrix metallopeptidase-2 (MMP-2) through the IP-dependent pathway.	ip	143-145	matrix metallopeptidase 2	Homo sapiens	124-129
29292033-11	2018	Taken together, these results demonstrate that iloprost inhibits ovarian cancer cell invasion by downregulating MMP-2 expression via the IP-mediated PKA pathway.	ip	137-139	matrix metallopeptidase 2	Homo sapiens	112-117