PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27608960-8	2016	Moreover, imperatorin and sec-O-glucosylhamaudol triggered Nrf2 activation, which resulted in upregulation of downstream phase II metabolic enzymes and antioxidant protein/enzyme, probably offering cellular protection to As2O3-induced cardiotoxicity via the Nrf2 signal pathway.	imperatorin	10-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	258-262
19150646-9	2009	These results strongly suggest that imperatorin and auraptene induce murine liver cytosolic GST activities via the Nrf2/ARE mechanism.	imperatorin	36-47	hematopoietic prostaglandin D synthase	Mus musculus	92-95
27608960-8	2016	Moreover, imperatorin and sec-O-glucosylhamaudol triggered Nrf2 activation, which resulted in upregulation of downstream phase II metabolic enzymes and antioxidant protein/enzyme, probably offering cellular protection to As2O3-induced cardiotoxicity via the Nrf2 signal pathway.	imperatorin	10-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	59-63
21730010-7	2011	The levels of interferon-gamma were enhanced, whereas the levels of interleukin (IL)-4 were reduced on the spleen tissue of the IPT-administered AR mice.	imperatorin	128-131	interleukin 4	Mus musculus	68-86
21730010-8	2011	Protein levels of IL-1beta, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice.	imperatorin	135-138	interleukin 1 beta	Mus musculus	18-26
21730010-8	2011	Protein levels of IL-1beta, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice.	imperatorin	135-138	chemokine (C-X-C motif) ligand 2	Mus musculus	28-61
21730010-8	2011	Protein levels of IL-1beta, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice.	imperatorin	135-138	intercellular adhesion molecule 1	Mus musculus	63-96
21730010-8	2011	Protein levels of IL-1beta, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice.	imperatorin	135-138	prostaglandin-endoperoxide synthase 2	Mus musculus	102-118
21730010-10	2011	In addition, IPT inhibited caspase-1 activity in the same nasal mucosa tissue.	imperatorin	13-16	caspase 1	Mus musculus	27-36
21730010-12	2011	In addition, IPT inhibited caspase-1 activity and IL-1beta production in IgE-stimulated bone marrow-derived mast cells.	imperatorin	13-16	caspase 1	Mus musculus	27-36
21730010-12	2011	In addition, IPT inhibited caspase-1 activity and IL-1beta production in IgE-stimulated bone marrow-derived mast cells.	imperatorin	13-16	interleukin 1 beta	Mus musculus	50-58
21730010-13	2011	We can conclude that IPT exerts significant effects by regulating of caspase-1 activation in AR animal and in vitro models.	imperatorin	21-24	caspase 1	Mus musculus	69-78
24569998-5	2014	A specific TRPV1 antagonist, JNJ-17203212 (0.5 muM), potently inhibited imperatorin-induced TRPV1 activation.	imperatorin	72-83	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	11-16
24569998-5	2014	A specific TRPV1 antagonist, JNJ-17203212 (0.5 muM), potently inhibited imperatorin-induced TRPV1 activation.	imperatorin	72-83	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	92-97
21991256-3	2011	In a previous study, we identified five natural coumarin potentiators of DeltaF508-CFTR including osthole, imperatorin, isopsoralen, praeruptorin A, and scoparone.	imperatorin	107-118	CF transmembrane conductance regulator	Rattus norvegicus	83-87
19150646-6	2009	Oltipraz, auraptene, imperatorin, isopimpinellin, and auraptene all significantly increased liver cytosolic GST activities in Nrf2 heterozygous mice.	imperatorin	21-32	hematopoietic prostaglandin D synthase	Mus musculus	108-111
19150646-9	2009	These results strongly suggest that imperatorin and auraptene induce murine liver cytosolic GST activities via the Nrf2/ARE mechanism.	imperatorin	36-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
19150646-6	2009	Oltipraz, auraptene, imperatorin, isopimpinellin, and auraptene all significantly increased liver cytosolic GST activities in Nrf2 heterozygous mice.	imperatorin	21-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	126-130
12193260-5	2002	Furthermore, imperatorin-induced apoptosis was significantly blocked by Z-VAD-FMK (a broad spectrum caspase inhibitor), Z-LEHD-FMK (a caspase-9 inhibitor) and Ac-DMQD-CHO (a caspase-3 inhibitor), but not by Z-IEDT-FMK (a caspase-8 inhibitor).	imperatorin	13-24	caspase 9	Homo sapiens	134-143
12193260-5	2002	Furthermore, imperatorin-induced apoptosis was significantly blocked by Z-VAD-FMK (a broad spectrum caspase inhibitor), Z-LEHD-FMK (a caspase-9 inhibitor) and Ac-DMQD-CHO (a caspase-3 inhibitor), but not by Z-IEDT-FMK (a caspase-8 inhibitor).	imperatorin	13-24	caspase 3	Homo sapiens	174-183
12193260-5	2002	Furthermore, imperatorin-induced apoptosis was significantly blocked by Z-VAD-FMK (a broad spectrum caspase inhibitor), Z-LEHD-FMK (a caspase-9 inhibitor) and Ac-DMQD-CHO (a caspase-3 inhibitor), but not by Z-IEDT-FMK (a caspase-8 inhibitor).	imperatorin	13-24	caspase 8	Homo sapiens	221-230
11931707-1	2002	AIM: To investigate the expression level of intercellular adhesion molecule-1 (ICAM-1) in a macrophage-derived foam cell model from human U937 cell line and the inhibitory effect of imperatorin (IMP) on the ICAM-1.	imperatorin	182-193	intercellular adhesion molecule 1	Homo sapiens	207-213
11931707-8	2002	Especially when pretreated with IMP 100 micromol/L, the ICAM-1 protein level decreased by 79 % and the mRNA level decreased by 74 % each compared to the level of foam cells.	imperatorin	32-35	intercellular adhesion molecule 1	Homo sapiens	56-62
8042516-4	1994	At concentrations from 10(-6) to 10(-4) mol.L-1, both imperatorin (Imp) and iso-imperatorin (Isi) were found to antagonize the TNF induced proliferation of BCSMC.	imperatorin	54-65	tumor necrosis factor	Bos taurus	127-130
8042516-4	1994	At concentrations from 10(-6) to 10(-4) mol.L-1, both imperatorin (Imp) and iso-imperatorin (Isi) were found to antagonize the TNF induced proliferation of BCSMC.	imperatorin	67-70	tumor necrosis factor	Bos taurus	127-130
33883654-12	2021	Meanwhile, IMP-treatment markedly improved synaptic ultrastructure morphology, increased the SAZ length, PSD thickness and up-regulated PSD-95 expression.	imperatorin	11-14	discs large MAGUK scaffold protein 4	Rattus norvegicus	136-142
8117927-7	1993	Furthermore, experiments using a two-stage incubation assay revealed that coriandrin, imperatorin, ostruthin, and several other natural coumarins inactivated hepatic EROD activity (i.e., predominantly cytochrome P450 1A1-mediated) and that isopimpinellin inactivated hepatic PROD activity (i.e., predominantly cytochrome P450 2B1-mediated).	imperatorin	86-97	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	201-220
8461033-5	1993	The furanocoumarins bergapten (5-methoxypsoralen), isopimpinellin (5,8-dimethoxypsoralen), imperatorin and sphondin also effectively inhibited mouse COH activity (IC50 values 19-40 microM).	imperatorin	91-102	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	149-152
33387483-4	2021	In this study, we focused on the therapeutical mechanism of IMP on MRGPRX2-induced pseudo-allergy and allergic asthma.	imperatorin	60-63	MAS-related GPR, member X2	Mus musculus	67-74
33387483-5	2021	METHODS: We examined the effect of IMP on MRGPRX2 related mast cell activation in mouse peritoneal MC (MPMC), Human Laboratory of Allergic Disease 2 MCs (LAD2 cells) and Mrgprx2-expressing HEK293 cells.	imperatorin	35-38	MAS-related GPR, member X2	Mus musculus	42-49
33387483-9	2021	The therapeutic effect of IMP on asthma was evaluated by a lung inflammation mouse model which was induced by ovalbumin (OVA).	imperatorin	26-29	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	110-119
33387483-9	2021	The therapeutic effect of IMP on asthma was evaluated by a lung inflammation mouse model which was induced by ovalbumin (OVA).	imperatorin	26-29	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	121-124
33409275-8	2020	IMP-treated aged oocytes also showed significantly higher expression of MOS, CCNB1, BMP15, and GDF9 than non-IMP-treated aged oocytes although their levels were still lower than those in the fresh oocytes.	imperatorin	0-3	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	72-75
33409275-8	2020	IMP-treated aged oocytes also showed significantly higher expression of MOS, CCNB1, BMP15, and GDF9 than non-IMP-treated aged oocytes although their levels were still lower than those in the fresh oocytes.	imperatorin	0-3	cyclin B1	Homo sapiens	77-82
33409275-8	2020	IMP-treated aged oocytes also showed significantly higher expression of MOS, CCNB1, BMP15, and GDF9 than non-IMP-treated aged oocytes although their levels were still lower than those in the fresh oocytes.	imperatorin	0-3	bone morphogenetic protein 15	Homo sapiens	84-89
33409275-8	2020	IMP-treated aged oocytes also showed significantly higher expression of MOS, CCNB1, BMP15, and GDF9 than non-IMP-treated aged oocytes although their levels were still lower than those in the fresh oocytes.	imperatorin	0-3	growth differentiation factor 9	Homo sapiens	95-99
31900049-6	2020	Our study has shown that IMP could regulate the signaling pathways including MAPK, PI3K/Akt, NF-kappaB, and Nrf2/HO-1 to release the inflammatory responses.	imperatorin	25-28	AKT serine/threonine kinase 1	Homo sapiens	88-91
32281712-7	2020	Additionally, IMP treatment significantly increased BDNF, TrkB, CaMKII, and CREB mRNA expression in the hippocampus of offspring rats.	imperatorin	14-17	brain-derived neurotrophic factor	Rattus norvegicus	52-56
32281712-7	2020	Additionally, IMP treatment significantly increased BDNF, TrkB, CaMKII, and CREB mRNA expression in the hippocampus of offspring rats.	imperatorin	14-17	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	58-62
32281712-7	2020	Additionally, IMP treatment significantly increased BDNF, TrkB, CaMKII, and CREB mRNA expression in the hippocampus of offspring rats.	imperatorin	14-17	cAMP responsive element binding protein 1	Rattus norvegicus	76-80
32281712-8	2020	Furthermore, PS-mediated induction of RKIP protein and mRNA expression and glucocorticoid receptor protein expression in the hippocampus of offspring rats were significantly decreased by IMP treatment, and the protein expression of BDNF and TrkB and relative levels of p-EKR/ERK, p-CaMKIIalpha/CaMKIIalpha, and p-CREB/CREB were remarkably increased after IMP treatment.	imperatorin	187-190	phosphatidylethanolamine binding protein 1	Rattus norvegicus	38-42
32392637-7	2020	Moreover, LTA, CD83, and SREBF1 were 3 important targets for synergistic mechanism of IMP+STO treatment.	imperatorin	86-89	lymphotoxin alpha	Rattus norvegicus	10-13
32392637-7	2020	Moreover, LTA, CD83, and SREBF1 were 3 important targets for synergistic mechanism of IMP+STO treatment.	imperatorin	86-89	CD83 molecule	Rattus norvegicus	15-19
32392637-7	2020	Moreover, LTA, CD83, and SREBF1 were 3 important targets for synergistic mechanism of IMP+STO treatment.	imperatorin	86-89	sterol regulatory element binding transcription factor 1	Rattus norvegicus	25-31
32454943-8	2020	Taken together, it is the first time to demonstrate that IMP exerts protective effects against APAP overdose-induced hepatotoxicity by stimulating the SIRT1-FXR pathway.	imperatorin	57-60	sirtuin 1	Mus musculus	151-156
32454943-8	2020	Taken together, it is the first time to demonstrate that IMP exerts protective effects against APAP overdose-induced hepatotoxicity by stimulating the SIRT1-FXR pathway.	imperatorin	57-60	nuclear receptor subfamily 1, group H, member 4	Mus musculus	157-160
31900049-6	2020	Our study has shown that IMP could regulate the signaling pathways including MAPK, PI3K/Akt, NF-kappaB, and Nrf2/HO-1 to release the inflammatory responses.	imperatorin	25-28	nuclear factor kappa B subunit 1	Homo sapiens	93-102
31900049-6	2020	Our study has shown that IMP could regulate the signaling pathways including MAPK, PI3K/Akt, NF-kappaB, and Nrf2/HO-1 to release the inflammatory responses.	imperatorin	25-28	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
31900049-6	2020	Our study has shown that IMP could regulate the signaling pathways including MAPK, PI3K/Akt, NF-kappaB, and Nrf2/HO-1 to release the inflammatory responses.	imperatorin	25-28	heme oxygenase 1	Homo sapiens	113-117
31900049-7	2020	IMP might attenuate airway remodeling by the down-regulation of Nrf2/HO-1/ROS/PI3K/Akt, Nrf2/HO-1/ROS/MAPK, and Nrf2/HO-1/ROS/NF-kappaB signaling pathways.	imperatorin	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
31900049-7	2020	IMP might attenuate airway remodeling by the down-regulation of Nrf2/HO-1/ROS/PI3K/Akt, Nrf2/HO-1/ROS/MAPK, and Nrf2/HO-1/ROS/NF-kappaB signaling pathways.	imperatorin	0-3	heme oxygenase 1	Homo sapiens	69-73
31900049-7	2020	IMP might attenuate airway remodeling by the down-regulation of Nrf2/HO-1/ROS/PI3K/Akt, Nrf2/HO-1/ROS/MAPK, and Nrf2/HO-1/ROS/NF-kappaB signaling pathways.	imperatorin	0-3	AKT serine/threonine kinase 1	Homo sapiens	83-86
31900049-7	2020	IMP might attenuate airway remodeling by the down-regulation of Nrf2/HO-1/ROS/PI3K/Akt, Nrf2/HO-1/ROS/MAPK, and Nrf2/HO-1/ROS/NF-kappaB signaling pathways.	imperatorin	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
31900049-7	2020	IMP might attenuate airway remodeling by the down-regulation of Nrf2/HO-1/ROS/PI3K/Akt, Nrf2/HO-1/ROS/MAPK, and Nrf2/HO-1/ROS/NF-kappaB signaling pathways.	imperatorin	0-3	heme oxygenase 1	Homo sapiens	93-97
31900049-7	2020	IMP might attenuate airway remodeling by the down-regulation of Nrf2/HO-1/ROS/PI3K/Akt, Nrf2/HO-1/ROS/MAPK, and Nrf2/HO-1/ROS/NF-kappaB signaling pathways.	imperatorin	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
31900049-7	2020	IMP might attenuate airway remodeling by the down-regulation of Nrf2/HO-1/ROS/PI3K/Akt, Nrf2/HO-1/ROS/MAPK, and Nrf2/HO-1/ROS/NF-kappaB signaling pathways.	imperatorin	0-3	heme oxygenase 1	Homo sapiens	93-97
31900049-7	2020	IMP might attenuate airway remodeling by the down-regulation of Nrf2/HO-1/ROS/PI3K/Akt, Nrf2/HO-1/ROS/MAPK, and Nrf2/HO-1/ROS/NF-kappaB signaling pathways.	imperatorin	0-3	nuclear factor kappa B subunit 1	Homo sapiens	126-135
31883297-5	2020	In this study, we used rat bone marrow-derived mesenchymal stem cells and found that imperatorin can activate RUNX2, COL1A1 and osteocalcin by promoting the Ser9 phosphorylation of GSK3beta and entry of beta-catenin into the nucleus.	imperatorin	85-96	RUNX family transcription factor 2	Rattus norvegicus	110-115
31883297-5	2020	In this study, we used rat bone marrow-derived mesenchymal stem cells and found that imperatorin can activate RUNX2, COL1A1 and osteocalcin by promoting the Ser9 phosphorylation of GSK3beta and entry of beta-catenin into the nucleus.	imperatorin	85-96	collagen type I alpha 1 chain	Rattus norvegicus	117-123
31883297-5	2020	In this study, we used rat bone marrow-derived mesenchymal stem cells and found that imperatorin can activate RUNX2, COL1A1 and osteocalcin by promoting the Ser9 phosphorylation of GSK3beta and entry of beta-catenin into the nucleus.	imperatorin	85-96	glycogen synthase kinase 3 beta	Rattus norvegicus	181-189
31883297-5	2020	In this study, we used rat bone marrow-derived mesenchymal stem cells and found that imperatorin can activate RUNX2, COL1A1 and osteocalcin by promoting the Ser9 phosphorylation of GSK3beta and entry of beta-catenin into the nucleus.	imperatorin	85-96	catenin beta 1	Rattus norvegicus	203-215
31883297-7	2020	We used ipatasertib, a pan-AKT inhibitor, to inhibit the osteogenic effect of imperatorin, and found that imperatorin promotes osteogenesis via AKT/GSK3beta/beta-catenin pathway.	imperatorin	106-117	AKT serine/threonine kinase 1	Rattus norvegicus	27-30
31883297-7	2020	We used ipatasertib, a pan-AKT inhibitor, to inhibit the osteogenic effect of imperatorin, and found that imperatorin promotes osteogenesis via AKT/GSK3beta/beta-catenin pathway.	imperatorin	106-117	AKT serine/threonine kinase 1	Rattus norvegicus	144-147
31883297-7	2020	We used ipatasertib, a pan-AKT inhibitor, to inhibit the osteogenic effect of imperatorin, and found that imperatorin promotes osteogenesis via AKT/GSK3beta/beta-catenin pathway.	imperatorin	106-117	glycogen synthase kinase 3 beta	Rattus norvegicus	148-156
31883297-7	2020	We used ipatasertib, a pan-AKT inhibitor, to inhibit the osteogenic effect of imperatorin, and found that imperatorin promotes osteogenesis via AKT/GSK3beta/beta-catenin pathway.	imperatorin	106-117	catenin beta 1	Rattus norvegicus	157-169
29957472-0	2018	Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-alpha mediated inflammatory/tumor markers.	imperatorin	48-58	tumor necrosis factor	Mus musculus	104-113
29957472-10	2018	Marmelosin thus displayed potential multi-potent antioxidant, anti-inflammatory and anticancer properties via TNF-alpha mediated Akt signaling pathway.	imperatorin	0-10	tumor necrosis factor	Mus musculus	110-119
29945292-5	2018	The inhibitory effects of IMP on NF-kappaB activity were evaluated by a reporter assay and NF-kappaB p65 nuclear translocation.	imperatorin	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
29945292-12	2018	IMP ameliorated DSS-induced colitis by PXR/NF-kappaB signalling.	imperatorin	0-3	nuclear receptor subfamily 1, group I, member 2	Mus musculus	39-42
29945292-12	2018	IMP ameliorated DSS-induced colitis by PXR/NF-kappaB signalling.	imperatorin	0-3	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
29945292-4	2018	EXPERIMENTAL APPROACH: The effects of IMP on PXR-modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two-hybrid assay, a competitive ligand-binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell-based reporter gene assay and in vitro model.	imperatorin	38-41	nuclear receptor subfamily 1 group I member 2	Homo sapiens	45-48
29945292-4	2018	EXPERIMENTAL APPROACH: The effects of IMP on PXR-modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two-hybrid assay, a competitive ligand-binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell-based reporter gene assay and in vitro model.	imperatorin	38-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-78
29945292-4	2018	EXPERIMENTAL APPROACH: The effects of IMP on PXR-modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two-hybrid assay, a competitive ligand-binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell-based reporter gene assay and in vitro model.	imperatorin	38-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-86
29945292-4	2018	EXPERIMENTAL APPROACH: The effects of IMP on PXR-modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two-hybrid assay, a competitive ligand-binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell-based reporter gene assay and in vitro model.	imperatorin	38-41	nuclear receptor subfamily 1 group I member 2	Homo sapiens	121-124
29577119-8	2018	The results showed that IPT significantly reduced cell viability, accelerated cell apoptosis and decreased matrix metalloproteinases-1/-3 expression in IL-1beta-induced RA-FLSs.	imperatorin	24-27	interleukin 1 beta	Homo sapiens	152-160
29577119-10	2018	Moreover, IPT increased the release of mitochondrial cytochrome C, the ratio of Bax/Bcl-2, and the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase.	imperatorin	10-13	cytochrome c, somatic	Homo sapiens	53-65
29577119-10	2018	Moreover, IPT increased the release of mitochondrial cytochrome C, the ratio of Bax/Bcl-2, and the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase.	imperatorin	10-13	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
29577119-10	2018	Moreover, IPT increased the release of mitochondrial cytochrome C, the ratio of Bax/Bcl-2, and the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase.	imperatorin	10-13	BCL2 apoptosis regulator	Homo sapiens	84-89
29577119-10	2018	Moreover, IPT increased the release of mitochondrial cytochrome C, the ratio of Bax/Bcl-2, and the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase.	imperatorin	10-13	caspase 9	Homo sapiens	111-120
29577119-10	2018	Moreover, IPT increased the release of mitochondrial cytochrome C, the ratio of Bax/Bcl-2, and the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase.	imperatorin	10-13	caspase 3	Homo sapiens	122-164