PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33884520-5 2022 In the present investigation, we applied a highly sensitive transcriptomic approach to investigate the effect of low concentrations of five PAs (lasiocarpine, riddelliine, lycopsamine, echimidine, and monocrotaline) on human cytochrome P450 3A4-overexpressing HepG2 clone 9 hepatocytes. echimidine 185-195 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 225-244 24375927-0 2014 Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine. echimidine 152-162 ATP binding cassette subfamily B member 1 Homo sapiens 122-127 29665350-9 2018 However, significant activation was found for PXR, which was exclusively activated by the open-chain diesters, echimidine and lasiocarpine. echimidine 111-121 nuclear receptor subfamily 1 group I member 2 Homo sapiens 46-49