PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 32159381-8 2020 In addition, the treatment with laminarin (35 mg/mL for 48 h) significantly upregulated SMP-30 in Bel-7404 and HepG2 cells but not in LO2 cells. laminaran 32-41 regucalcin Homo sapiens 88-94 35253618-4 2022 Among the algal compounds screened in this study, three (Laminarin, Astaxanthin and 4"-chlorostypotriol triacetate) exhibited the lowest docking energy and best interaction with SARS-CoV-2 viral proteins (Main protease, RdRp, Nsp15, and spike protein). laminaran 57-66 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 220-224 35253618-4 2022 Among the algal compounds screened in this study, three (Laminarin, Astaxanthin and 4"-chlorostypotriol triacetate) exhibited the lowest docking energy and best interaction with SARS-CoV-2 viral proteins (Main protease, RdRp, Nsp15, and spike protein). laminaran 57-66 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 237-242 2506010-1 1989 Beta-1,3-Glucanase (laminarinase) activity was detected after polyacrylamide gel electrophoresis under native conditions by using laminarin as substrate. laminaran 20-29 glucan endo-1,3-beta-glucosidase, acidic-like Nicotiana tabacum 0-18 33705858-11 2021 To determine whether the antidepressant effect was mediated by Dectin-1, we found that GLP treatment enhanced Dectin-1 expression in the hippocampus in CSDS mice, and the Dectin-1-specific inhibitor laminarin almost completely blocked the antidepressant effect of GLP. laminaran 199-208 C-type lectin domain family 7, member a Mus musculus 63-71 33705858-11 2021 To determine whether the antidepressant effect was mediated by Dectin-1, we found that GLP treatment enhanced Dectin-1 expression in the hippocampus in CSDS mice, and the Dectin-1-specific inhibitor laminarin almost completely blocked the antidepressant effect of GLP. laminaran 199-208 C-type lectin domain family 7, member a Mus musculus 110-118 33705858-11 2021 To determine whether the antidepressant effect was mediated by Dectin-1, we found that GLP treatment enhanced Dectin-1 expression in the hippocampus in CSDS mice, and the Dectin-1-specific inhibitor laminarin almost completely blocked the antidepressant effect of GLP. laminaran 199-208 C-type lectin domain family 7, member a Mus musculus 110-118 32608473-5 2020 Fungal dysbiosis was induced by 0.5% fluconazole (Flu), and commensal fungal recognition through dectin-1 was blocked by 5% laminarin. laminaran 124-133 C-type lectin domain containing 7A Homo sapiens 97-105 32608473-12 2020 In the Flu and laminarin groups, the expression of interferon-gamma, tumor necrosis factor-alpha, CARD9, and phosphorylated nuclear factor kappa-B inhibitor alpha was decreased. laminaran 15-24 interferon gamma Homo sapiens 51-67 32608473-12 2020 In the Flu and laminarin groups, the expression of interferon-gamma, tumor necrosis factor-alpha, CARD9, and phosphorylated nuclear factor kappa-B inhibitor alpha was decreased. laminaran 15-24 tumor necrosis factor Homo sapiens 69-96 32608473-12 2020 In the Flu and laminarin groups, the expression of interferon-gamma, tumor necrosis factor-alpha, CARD9, and phosphorylated nuclear factor kappa-B inhibitor alpha was decreased. laminaran 15-24 caspase recruitment domain family member 9 Homo sapiens 98-103 31925978-7 2020 Hydrolysis of the beta-1,6 side branches of laminarin demonstrated that not the glycosidic decoration but rather the degree of polymerization plays a pivotal role in the recognition of long-chain beta-glucans. laminaran 44-53 beta-1,2-xylosyltransferase Arabidopsis thaliana 18-26 16667843-4 1990 With a new method of activity staining using laminarin-Remazol brilliant blue as substrate in overlay gels, 18 electrophoretic forms of endo-beta-1,3-glucanase were detected in IWF from unstressed leaves and up to 24 forms in IWF from stem rust-infected leaves. laminaran 45-54 glucan endo-1,3-beta-glucosidase 14 Triticum aestivum 141-159 2390977-8 1990 A useful in vitro system to study the immune response has been found in Schneider"s line 2 cells which respond to lipopolysaccharide and laminarin by cecropin expression. laminaran 137-146 Cecropin A1 Drosophila melanogaster 150-158 30283149-7 2018 The interaction between the particles and biologically relevant proteins for HA and LAM, namely CD44 and Dectin-1 respectively, was evaluated by surface plasmon resonance (SPR). laminaran 84-87 CD44 molecule (Indian blood group) Homo sapiens 96-100 32159381-9 2020 Conclusion: Laminarin inhibited the proliferation of Bel-7404 and HepG2 cells and inhibited the growth of tumors in Hepa 1-6 tumor-bearing mice by upregulating SMP-30. laminaran 12-21 regucalcin Mus musculus 160-166 32140046-8 2019 In vitro, laminarin increased the cytotoxicity, NKp30 and NKG2D, perforin and granzyme B expressions of NK92-MI cells (p < 0.01). laminaran 10-19 natural cytotoxicity triggering receptor 3 Homo sapiens 48-53 31926564-9 2020 The Dectin-1 antagonist LAM or Syk inhibitor PIC decreased the number of Iba1-positive cells and TNF-alpha and iNOS expression, decreased the brain infarct volume, and improved neurological functions on day 3 after ischemic stroke. laminaran 24-27 C-type lectin domain family 7, member a Mus musculus 4-12 31926564-9 2020 The Dectin-1 antagonist LAM or Syk inhibitor PIC decreased the number of Iba1-positive cells and TNF-alpha and iNOS expression, decreased the brain infarct volume, and improved neurological functions on day 3 after ischemic stroke. laminaran 24-27 induction of brown adipocytes 1 Mus musculus 73-77 31926564-9 2020 The Dectin-1 antagonist LAM or Syk inhibitor PIC decreased the number of Iba1-positive cells and TNF-alpha and iNOS expression, decreased the brain infarct volume, and improved neurological functions on day 3 after ischemic stroke. laminaran 24-27 tumor necrosis factor Mus musculus 97-106 31926564-9 2020 The Dectin-1 antagonist LAM or Syk inhibitor PIC decreased the number of Iba1-positive cells and TNF-alpha and iNOS expression, decreased the brain infarct volume, and improved neurological functions on day 3 after ischemic stroke. laminaran 24-27 nitric oxide synthase 2, inducible Mus musculus 111-115 31926564-11 2020 LAM and PIC also decreased TNF-alpha and iNOS expression 3 h after OGD/R induction. laminaran 0-3 tumor necrosis factor Mus musculus 27-36 31926564-11 2020 LAM and PIC also decreased TNF-alpha and iNOS expression 3 h after OGD/R induction. laminaran 0-3 nitric oxide synthase 2, inducible Mus musculus 41-45 31640819-8 2020 Laminarin supplementation increased the expression of SLC2A8/GLUT8 in the duodenum, SLC2A2/GLUT2, SLC2A7/GLUT7, SLC15A1/PEPT1 and FABP2 in the jejunum, and SLC16A1/MCT1 in the colon. laminaran 0-9 solute carrier family 2 member 8 Sus scrofa 54-60 31640819-8 2020 Laminarin supplementation increased the expression of SLC2A8/GLUT8 in the duodenum, SLC2A2/GLUT2, SLC2A7/GLUT7, SLC15A1/PEPT1 and FABP2 in the jejunum, and SLC16A1/MCT1 in the colon. laminaran 0-9 solute carrier family 2 member 2 Sus scrofa 84-90 31640819-8 2020 Laminarin supplementation increased the expression of SLC2A8/GLUT8 in the duodenum, SLC2A2/GLUT2, SLC2A7/GLUT7, SLC15A1/PEPT1 and FABP2 in the jejunum, and SLC16A1/MCT1 in the colon. laminaran 0-9 solute carrier family 2 member 2 Sus scrofa 91-96 31640819-8 2020 Laminarin supplementation increased the expression of SLC2A8/GLUT8 in the duodenum, SLC2A2/GLUT2, SLC2A7/GLUT7, SLC15A1/PEPT1 and FABP2 in the jejunum, and SLC16A1/MCT1 in the colon. laminaran 0-9 SLC2A7 Sus scrofa 98-104 31640819-8 2020 Laminarin supplementation increased the expression of SLC2A8/GLUT8 in the duodenum, SLC2A2/GLUT2, SLC2A7/GLUT7, SLC15A1/PEPT1 and FABP2 in the jejunum, and SLC16A1/MCT1 in the colon. laminaran 0-9 solute carrier family 15 member 1 Sus scrofa 112-119 31640819-8 2020 Laminarin supplementation increased the expression of SLC2A8/GLUT8 in the duodenum, SLC2A2/GLUT2, SLC2A7/GLUT7, SLC15A1/PEPT1 and FABP2 in the jejunum, and SLC16A1/MCT1 in the colon. laminaran 0-9 fatty acid binding protein 2 Sus scrofa 130-135 31640819-8 2020 Laminarin supplementation increased the expression of SLC2A8/GLUT8 in the duodenum, SLC2A2/GLUT2, SLC2A7/GLUT7, SLC15A1/PEPT1 and FABP2 in the jejunum, and SLC16A1/MCT1 in the colon. laminaran 0-9 monocarboxylate transporter 1 Sus scrofa 156-163 31640819-8 2020 Laminarin supplementation increased the expression of SLC2A8/GLUT8 in the duodenum, SLC2A2/GLUT2, SLC2A7/GLUT7, SLC15A1/PEPT1 and FABP2 in the jejunum, and SLC16A1/MCT1 in the colon. laminaran 0-9 MCT1 Sus scrofa 164-168 32140046-8 2019 In vitro, laminarin increased the cytotoxicity, NKp30 and NKG2D, perforin and granzyme B expressions of NK92-MI cells (p < 0.01). laminaran 10-19 killer cell lectin like receptor K1 Homo sapiens 58-63 32140046-8 2019 In vitro, laminarin increased the cytotoxicity, NKp30 and NKG2D, perforin and granzyme B expressions of NK92-MI cells (p < 0.01). laminaran 10-19 granzyme B Homo sapiens 78-88 29246954-2 2018 Laminarin is a (1 3, 1 6)-beta-glucan that is widely reported to be a Dectin-1 antagonist, however, there are reports that laminarin is also a Dectin-1 agonist. laminaran 0-9 C-type lectin domain containing 7A Homo sapiens 70-78 32450040-7 2019 Furthermore, the expression profiles of beta-catenin, Bcl-2, and Bax reversed with the administration of laminarin (P < 0.05). laminaran 105-114 catenin (cadherin associated protein), beta 1 Mus musculus 40-52 32450040-7 2019 Furthermore, the expression profiles of beta-catenin, Bcl-2, and Bax reversed with the administration of laminarin (P < 0.05). laminaran 105-114 B cell leukemia/lymphoma 2 Mus musculus 54-59 32450040-7 2019 Furthermore, the expression profiles of beta-catenin, Bcl-2, and Bax reversed with the administration of laminarin (P < 0.05). laminaran 105-114 BCL2-associated X protein Mus musculus 65-68 30270255-8 2018 Mitochondrial membrane potential was increased, and the activities of caspase-3 and cathepsin B were significantly reduced in the LAM-treated aged oocytes compared with the non-treated aged oocytes. laminaran 130-133 caspase 3 Sus scrofa 70-79 30270255-8 2018 Mitochondrial membrane potential was increased, and the activities of caspase-3 and cathepsin B were significantly reduced in the LAM-treated aged oocytes compared with the non-treated aged oocytes. laminaran 130-133 cathepsin B Sus scrofa 84-95 29246954-2 2018 Laminarin is a (1 3, 1 6)-beta-glucan that is widely reported to be a Dectin-1 antagonist, however, there are reports that laminarin is also a Dectin-1 agonist. laminaran 123-132 C-type lectin domain containing 7A Homo sapiens 143-151 29245916-6 2017 Furthermore, laminarin-induced appetite reduction was totally blocked by Exendin (9-39), a specific competitive inhibitor of GLP-1 receptor. laminaran 13-22 glucagon-like peptide 1 receptor Mus musculus 125-139 28326085-5 2017 With that intent, we observed that the absence of Dectin-1, observed in genetically depleted (Dectin-1-/-) mice or competitively inhibited by an inert agonist [laminarin (LAM)], rescued 50% of the mice infected with lethal doses of N. caninum. laminaran 160-169 C-type lectin domain family 7, member a Mus musculus 50-58 28326085-5 2017 With that intent, we observed that the absence of Dectin-1, observed in genetically depleted (Dectin-1-/-) mice or competitively inhibited by an inert agonist [laminarin (LAM)], rescued 50% of the mice infected with lethal doses of N. caninum. laminaran 171-174 C-type lectin domain family 7, member a Mus musculus 50-58 28326085-9 2017 We also found that Dectin-1+ cells produced less reactive oxygen species (ROS) at the initial site of the infection, while mice deficient in NADPH oxidase isoform 2 (NOX2-/-) were not able to control parasite replication and produce IL-12p40, even upon LAM treatment. laminaran 253-256 C-type lectin domain family 7, member a Mus musculus 19-27 27095402-4 2016 Lam induced expression of IRT1, ZIP8, and copper transporters involved in transport of Fe, Zn, Cu ions associated with the activity of chloroplast antioxidant system. laminaran 0-3 iron-regulated transporter 1 Arabidopsis thaliana 26-30 27095402-4 2016 Lam induced expression of IRT1, ZIP8, and copper transporters involved in transport of Fe, Zn, Cu ions associated with the activity of chloroplast antioxidant system. laminaran 0-3 ZIP8 Arabidopsis thaliana 32-36 26606296-12 2016 Curdlan increased the production of the MR (1.5-fold, 1.9-fold of the control), whereas laminarin decreased the expression of the MR (50%, 60% reduction) induced by A. fumigatus. laminaran 88-97 mannose receptor C-type 1 Homo sapiens 130-132 21251335-7 2011 Dietary supplementation of 600 ppm laminarin led to a significant increase in MUC2 (P = 0 0365) and MUC4 (P = 0 0401) expression in the colon, and in the total VFA concentration in the caecum (P = 0 0489). laminaran 35-44 LOW QUALITY PROTEIN: mucin-2 Sus scrofa 78-82 23365357-8 2012 Pigs offered the LAM-supplemented diets had a lower IL-6 (P < 0.05), IL-17 (P < 0.001), and IL-1beta (P < 0.001) mRNA expression in the colon compared with pigs offered diets without LAM supplementation. laminaran 17-20 interleukin 6 Sus scrofa 52-56 23365357-8 2012 Pigs offered the LAM-supplemented diets had a lower IL-6 (P < 0.05), IL-17 (P < 0.001), and IL-1beta (P < 0.001) mRNA expression in the colon compared with pigs offered diets without LAM supplementation. laminaran 17-20 interleukin-17A Sus scrofa 72-77 23365357-8 2012 Pigs offered the LAM-supplemented diets had a lower IL-6 (P < 0.05), IL-17 (P < 0.001), and IL-1beta (P < 0.001) mRNA expression in the colon compared with pigs offered diets without LAM supplementation. laminaran 17-20 interleukin-1 beta Sus scrofa 98-106 21424514-6 2011 Observations based on injection of curdlan, laminarin or mannan supported the dominant role of the Dectin-1 pathway in the joint. laminaran 44-53 C-type lectin domain family 7, member a Mus musculus 99-107 21251335-7 2011 Dietary supplementation of 600 ppm laminarin led to a significant increase in MUC2 (P = 0 0365) and MUC4 (P = 0 0401) expression in the colon, and in the total VFA concentration in the caecum (P = 0 0489). laminaran 35-44 mucin-4 Sus scrofa 100-104 17763336-4 2007 In contrast, DCs from susceptible mice produced high concentrations of TNF- alpha and IL-10, but IL-10 production was significantly inhibited in the presence of laminarin. laminaran 161-170 interleukin 10 Mus musculus 97-102 19396235-3 2009 Both chitinase and beta-1,3-glucanase enzymes were produced when C. rosea was grown on a synthetic medium containing chitin or laminarin as a sole carbon source, respectively. laminaran 127-136 acidic endochitinase Cucumis sativus 5-14 19323897-14 2009 Dectin-1 inhibitor laminarin blocked the CaIG-induced production of TNF-alpha and H(2)O(2) in THP-1 monocytes, but no such effect was observed in pretreatment with anti-TLR2 neutralizing antibody and the LPS inhibitor (polymyxin B). laminaran 19-28 C-type lectin domain containing 7A Homo sapiens 0-8 19323897-14 2009 Dectin-1 inhibitor laminarin blocked the CaIG-induced production of TNF-alpha and H(2)O(2) in THP-1 monocytes, but no such effect was observed in pretreatment with anti-TLR2 neutralizing antibody and the LPS inhibitor (polymyxin B). laminaran 19-28 tumor necrosis factor Homo sapiens 68-77 19323897-14 2009 Dectin-1 inhibitor laminarin blocked the CaIG-induced production of TNF-alpha and H(2)O(2) in THP-1 monocytes, but no such effect was observed in pretreatment with anti-TLR2 neutralizing antibody and the LPS inhibitor (polymyxin B). laminaran 19-28 GLI family zinc finger 2 Homo sapiens 94-99 18944288-5 2008 Conversely, high concentrations (200 or 400 microg ml(1)) of LPS, laminarin, and harpin N activated LOX in cells pretreated with 1 microg ml(1) CCF, but not in cells pretreated with LPS, laminarin, or harpin N. laminaran 66-75 probable linoleate 9S-lipoxygenase 5 Solanum tuberosum 100-103 19327548-8 2009 Addition of laminarin, a well-established dectin-1 inhibitor, significantly inhibited surface expression of dectin-1 (p < 0.05), which further confirmed that dectin-1 surface expression was up-regulated by non-opsonized zymosan activation. laminaran 12-21 C-type lectin domain family 7, member a Mus musculus 42-50 19327548-8 2009 Addition of laminarin, a well-established dectin-1 inhibitor, significantly inhibited surface expression of dectin-1 (p < 0.05), which further confirmed that dectin-1 surface expression was up-regulated by non-opsonized zymosan activation. laminaran 12-21 C-type lectin domain family 7, member a Mus musculus 108-116 19327548-8 2009 Addition of laminarin, a well-established dectin-1 inhibitor, significantly inhibited surface expression of dectin-1 (p < 0.05), which further confirmed that dectin-1 surface expression was up-regulated by non-opsonized zymosan activation. laminaran 12-21 C-type lectin domain family 7, member a Mus musculus 108-116 19049649-5 2008 In vitro production of TNF-alpha by peritoneal macrophages from MyD88-, TLR2- and TLR4-deficient mice in response to P. brasiliensis yeasts was undiminished, as compared with macrophages from WT mice, and, in addition, laminarin failed to inhibit production of TNF-alpha by WT and MyD88-deficient macrophages. laminaran 219-228 tumor necrosis factor Mus musculus 23-32 17920526-6 2007 The increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities - reflecting hepatic alterations - was lessened after LPS injection in LAM-treated rats compared to control rats. laminaran 201-204 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 54-80 17920526-7 2007 LAM treatment decreased serum monocytes number, nitrite (NO2) and tumor necrosis factor-alpha (TNF-alpha). laminaran 0-3 tumor necrosis factor Rattus norvegicus 66-93 17920526-7 2007 LAM treatment decreased serum monocytes number, nitrite (NO2) and tumor necrosis factor-alpha (TNF-alpha). laminaran 0-3 tumor necrosis factor Rattus norvegicus 95-104 17785780-3 2007 Treatment of SpDC with laminarin or glucan phosphate, two molecules known to block Dectin-1-dependent activity, led to a reduction in M. tuberculosis-induced IL-12p40 as well as IL-12p70 production. laminaran 23-32 C-type lectin domain family 7, member a Mus musculus 83-91 17761750-6 2007 These results suggest that NtMYBGR1 specifically regulates defense responses in BY-2 cells by enhancing phenylpropanoid metabolism in response to AaGlucan and laminarin elicitors. laminaran 159-168 protein ODORANT1-like Nicotiana tabacum 27-35 17785780-3 2007 Treatment of SpDC with laminarin or glucan phosphate, two molecules known to block Dectin-1-dependent activity, led to a reduction in M. tuberculosis-induced IL-12p40 as well as IL-12p70 production. laminaran 23-32 interleukin 12b Mus musculus 158-166 9025957-2 1997 Application has been demonstrated for neutral polysaccharide polymers such as laminarin (beta-1,3; branched), curdland (beta-1,3; unbranched), pullulan (alpha-1, 6-maltotriose), glycogen (alpha-1,4-glucan), and inulin (polyfructose). laminaran 78-87 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 89-97 17030235-10 2006 The dectin-1 inhibitors laminarin and glucan phosphate reduced the LTC4 response to zymosan by more than 60% but did not alter peptidoglycan responses. laminaran 24-33 C-type lectin domain containing 7A Homo sapiens 4-12 16755465-6 2006 In tomato cells, LPS PA and LPS PSC induced a strong but transitory stimulation of lipoxygenase activity, whereas laminarin induced a stable or slightly increasing LOX activity over the first 24 h of contact. laminaran 114-123 linoleate 9S-lipoxygenase 2 Solanum tuberosum 164-167 12391246-4 2002 Fucoidin, heparin/heparin sulfate, N-acetyl-D-glucosamine, mannose-6-phosphate, and laminarin were found to inhibit adhesion of T84 cells to CD11b/CD18. laminaran 84-93 integrin subunit alpha M Homo sapiens 141-146 12391246-4 2002 Fucoidin, heparin/heparin sulfate, N-acetyl-D-glucosamine, mannose-6-phosphate, and laminarin were found to inhibit adhesion of T84 cells to CD11b/CD18. laminaran 84-93 integrin subunit beta 2 Homo sapiens 147-151 8593430-7 1995 GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM). laminaran 103-112 granulin Mus musculus 0-3 8593430-7 1995 GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM). laminaran 103-112 tumor necrosis factor Mus musculus 14-23 8593430-7 1995 GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM). laminaran 114-117 granulin Mus musculus 0-3 8593430-7 1995 GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM). laminaran 114-117 tumor necrosis factor Mus musculus 14-23 8593430-10 1995 The inhibitory effect of LAM on the uptake of GRN by RAW264.7 cells was not completely correlated with TNF alpha release. laminaran 25-28 granulin Mus musculus 46-49