PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30548793-6	2019	In human VGSC experiments, using the Nav1.8 subtype, bifenthrin"s effects on inactivation were slight, as for Type II pyrethroids, but without large prolongation of the tail current (deactivation) seen with Type II.	bifenthrin	53-63	sodium voltage-gated channel alpha subunit 10	Homo sapiens	37-43
30548793-8	2019	CONCLUSION: In a DNT study and on human Nav1.8 tail currents bifenthrin showed Type I and II effects, similar to some published studies.	bifenthrin	61-71	sodium voltage-gated channel alpha subunit 10	Homo sapiens	40-46
29727771-5	2018	However, whether environmentally relevant levels of bifenthrin alter RyR or mTOR signaling pathways to influence neurodevelopment has not been addressed.	bifenthrin	52-62	mechanistic target of rapamycin kinase	Danio rerio	76-80
30553213-10	2019	At laboratory concentrations-(mug/L), permethrin-(1000) upregulated Nrf2a, Casp-9 and p53 expressions, bifenthrin-(10) upregulated Casp-9 while fenvalerate-(0.1) and esfenvalerate-(1000) downregulated GST.	bifenthrin	103-113	caspase 9, apoptosis-related cysteine peptidase	Danio rerio	131-137
30414561-0	2019	Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina).	bifenthrin	69-79	mechanistic target of rapamycin kinase	Danio rerio	104-108
29727771-0	2018	Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio).	bifenthrin	0-10	mechanistic target of rapamycin kinase	Danio rerio	48-52
30336432-0	2019	Evaluation of the estrogen receptor alpha as a possible target of bifenthrin effects in the estrogenic and dopaminergic signaling pathways in zebrafish embryos.	bifenthrin	66-76	estrogen receptor 1	Danio rerio	18-41
29775722-7	2018	BF-treated rats also exhibited increased oxidation of lipids and carbonylated proteins in the frontal cortex and striatum, and decreased glutathione levels and antioxidant enzyme activities including superoxide dismutase, catalase and glutathione peroxidase.	bifenthrin	0-2	catalase	Rattus norvegicus	222-230
29775722-10	2018	These data suggest that BF induced neurological alterations in the frontal cortex and striatum of rats, and that this may be associated with neuroinflammation and oxidative stress via the activation of Nrf2/NF-kBp65 pathways, which might promote anxiety-like behavior.	bifenthrin	24-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	202-206
29727771-6	2018	Therefore, our main objectives in this study were to examine the transcriptomic responses of genes involved in RyR and mTOR signaling pathways in zebrafish (Danio rerio) exposed to low (ng/L) concentrations of bifenthrin, and to assess the potential functional consequences by measuring locomotor responses to external stimuli.	bifenthrin	210-220	mechanistic target of rapamycin kinase	Danio rerio	119-123
29274435-7	2018	Pasta, salted bread and beans contributed most to the PYs intake (9-14%), mainly due to bifenthrin.	bifenthrin	88-98	solute carrier family 45 member 1	Homo sapiens	0-5
29707002-3	2018	Under the optimized conditions, a good linearity was shown for bifenthrin, fenpropathrin, permethrin, and cyfluthrin in 1-50 ng mL-1 and for cypermethrin, fenvalerate, and deltamethrin in 5-50 ng mL-1.	bifenthrin	63-73	L1 cell adhesion molecule	Mus musculus	128-132
29594621-7	2018	The detection limits for bifenthrin, fenpropathrin, lambda-cyhalothrin, permethrin, and deltamethrin range from 5 to 9 pg mL-1.	bifenthrin	25-35	L1 cell adhesion molecule	Mus musculus	122-126
29793499-9	2018	At sub-cytotoxic concentrations, BF increased reactive oxygen species (ROS), TNF-alpha synthesis, and prostaglandin E2 (PGE2) production, at both 4- and 24-h time points, respectively.	bifenthrin	33-35	tumor necrosis factor	Homo sapiens	77-86
28163254-0	2017	Multiple resistance to pirimiphos-methyl and bifenthrin in Tribolium castaneum involves the activity of lipases, esterases, and laccase2.	bifenthrin	45-55	laccase 2	Tribolium castaneum	128-136
26556752-8	2016	Molecular docking analyses revealed that at the atomic level, BF binds to thyroid hormone receptor (TRalpha) protein more potently than lambda-CH, consequently affecting HPT axis signal transduction.	bifenthrin	62-64	thyroid hormone receptor alpha a	Danio rerio	100-107
25392154-7	2015	However, when the ethoxylate mixture was combined with both diuron and bifenthrin, there was a significant increase in the relative mRNA expression of VTG in male compared with all other groups in the multichemical mixture.	bifenthrin	71-81	LOC100136735	Oncorhynchus mykiss	151-154
26647222-6	2016	In H4IIEcells, four organochlorine insecticides, bifenthrin, and 3-PBA decreased cortisol-induced PEPCK gene expression, while o,p"-DDT and methoxychlor inhibited cortisol-stimulated Arg and TAT gene expression.	bifenthrin	49-59	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	98-103
24482397-7	2014	By contrast, the metabotropic glutamate receptor (mGluR)5 antagonist MPEP [2-methyl-6-(phenylethynyl)pyridine] normalized bifenthrin-triggered increase in SCO frequency without altering baseline SCO activity, indicating that bifenthrin amplifies mGluR5 signaling independent of Na(+) channel modification.	bifenthrin	122-132	glutamate receptor, metabotropic 5	Mus musculus	17-57
24938463-9	2014	Using molecular docking, the enantioselective endocrine disruption of BF was predicted to be partially due to enantiospecific ER binding affinity.	bifenthrin	70-72	estrogen receptor 1	Homo sapiens	126-128
24938463-10	2014	Thus, BF could act through ER to enantioselectively disturb the hormonal network in trophoblast cells.	bifenthrin	6-8	estrogen receptor 1	Homo sapiens	27-29
25716972-15	2015	Subacute poisoning with the higher dose of BIF caused anaemia, elevated white blood cell count (WBC), elevated alanine transaminase (ALT), superoxide dismuthase (SOD), and decreased glutathione peroxidase (GPx) activity.	bifenthrin	43-46	glutamic pyruvic transaminase, soluble	Mus musculus	111-131
25716972-15	2015	Subacute poisoning with the higher dose of BIF caused anaemia, elevated white blood cell count (WBC), elevated alanine transaminase (ALT), superoxide dismuthase (SOD), and decreased glutathione peroxidase (GPx) activity.	bifenthrin	43-46	glutamic pyruvic transaminase, soluble	Mus musculus	133-136
23576335-5	2014	RESULTS: Treatments with bifenthrin, permethrin or fipronil all showed fast ant knockdown initially, and over 50% of ants were killed within 16 h after 1-min contact with the treated surfaces.	bifenthrin	25-35	solute carrier family 25 member 6	Homo sapiens	76-79
24482397-7	2014	By contrast, the metabotropic glutamate receptor (mGluR)5 antagonist MPEP [2-methyl-6-(phenylethynyl)pyridine] normalized bifenthrin-triggered increase in SCO frequency without altering baseline SCO activity, indicating that bifenthrin amplifies mGluR5 signaling independent of Na(+) channel modification.	bifenthrin	122-132	glutamate receptor, ionotropic, kainate 1	Mus musculus	246-252
24482397-7	2014	By contrast, the metabotropic glutamate receptor (mGluR)5 antagonist MPEP [2-methyl-6-(phenylethynyl)pyridine] normalized bifenthrin-triggered increase in SCO frequency without altering baseline SCO activity, indicating that bifenthrin amplifies mGluR5 signaling independent of Na(+) channel modification.	bifenthrin	225-235	glutamate receptor, metabotropic 5	Mus musculus	17-57
24482397-9	2014	Bifenthrin-modified SCO rapidly enhanced the phosphorylation of cAMP response element-binding protein (CREB).	bifenthrin	0-10	cAMP responsive element binding protein 1	Mus musculus	64-101
24482397-9	2014	Bifenthrin-modified SCO rapidly enhanced the phosphorylation of cAMP response element-binding protein (CREB).	bifenthrin	0-10	cAMP responsive element binding protein 1	Mus musculus	103-107
24482397-11	2014	Bifenthrin-stimulated neurite outgrowth and CREB phosphorylation were dependent on mGluR5 activity since MPEP normalized both responses.	bifenthrin	0-10	cAMP responsive element binding protein 1	Mus musculus	44-48
24482397-11	2014	Bifenthrin-stimulated neurite outgrowth and CREB phosphorylation were dependent on mGluR5 activity since MPEP normalized both responses.	bifenthrin	0-10	glutamate receptor, ionotropic, kainate 1	Mus musculus	83-89
25149237-8	2013	Moreover, the transcription of oxidative stress response related genes including Sod1, Cat and heme oxygenase-1(Ho-1) in the liver of 1S-cis-BF treated groups were also significant higher than those in 1R-cis-BF treated group.	bifenthrin	141-143	superoxide dismutase 1, soluble	Mus musculus	81-85
23728353-3	2013	Blood glutathione levels and activities of catalase and glutathione peroxidase decreased significantly in the bifenthrin treated animals after both 20 and 30 days of treatment, whereas, the activities of superoxide dismutase and glutathione S-transferase decreased significantly only on the 30th day.	bifenthrin	110-120	catalase	Rattus norvegicus	43-51
23728353-3	2013	Blood glutathione levels and activities of catalase and glutathione peroxidase decreased significantly in the bifenthrin treated animals after both 20 and 30 days of treatment, whereas, the activities of superoxide dismutase and glutathione S-transferase decreased significantly only on the 30th day.	bifenthrin	110-120	hematopoietic prostaglandin D synthase	Rattus norvegicus	229-254
25149237-8	2013	Moreover, the transcription of oxidative stress response related genes including Sod1, Cat and heme oxygenase-1(Ho-1) in the liver of 1S-cis-BF treated groups were also significant higher than those in 1R-cis-BF treated group.	bifenthrin	141-143	catalase	Mus musculus	87-90
25149237-8	2013	Moreover, the transcription of oxidative stress response related genes including Sod1, Cat and heme oxygenase-1(Ho-1) in the liver of 1S-cis-BF treated groups were also significant higher than those in 1R-cis-BF treated group.	bifenthrin	141-143	heme oxygenase 1	Mus musculus	95-111
21775671-9	2011	Quantitative RT-PCR assays demonstrated that tau-fluvalinate enhances CYP9Q3 transcripts, whereas the pyrethroid bifenthrin enhances CYP9Q1 and CYP9Q2 transcripts and represses CYP9Q3 transcripts.	bifenthrin	113-123	cytochrome P450 9e2	Apis mellifera	133-139
22939157-2	2012	The as-prepared MNPs/PSt were used as the adsorbent in magnetic solid phase extraction of five pyrethroids, including lambda-cyhalothrin, deltamethrin, esfenvalerate, permethrin, bifenthrin, in environmental water samples.	bifenthrin	179-189	sulfotransferase family 1A member 1	Homo sapiens	21-24
21775671-9	2011	Quantitative RT-PCR assays demonstrated that tau-fluvalinate enhances CYP9Q3 transcripts, whereas the pyrethroid bifenthrin enhances CYP9Q1 and CYP9Q2 transcripts and represses CYP9Q3 transcripts.	bifenthrin	113-123	cytochrome P450 9e2	Apis mellifera	144-150
21775671-9	2011	Quantitative RT-PCR assays demonstrated that tau-fluvalinate enhances CYP9Q3 transcripts, whereas the pyrethroid bifenthrin enhances CYP9Q1 and CYP9Q2 transcripts and represses CYP9Q3 transcripts.	bifenthrin	113-123	cytochrome P450 9e2	Apis mellifera	177-183
19043362-5	2008	RESULTS: Bifenthrin stimulated T-cell adhesion to fibronectin at concentrations between 1.0 and 100 microM with a maximal stimulation of 8.3-fold at 10 microM.	bifenthrin	9-19	fibronectin 1	Homo sapiens	50-61
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	174-181
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	steroidogenic acute regulatory protein	Rattus norvegicus	183-187
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	amphiregulin	Rattus norvegicus	193-197
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	transforming growth factor, beta 1	Rattus norvegicus	205-214
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	CCAAT/enhancer binding protein beta	Rattus norvegicus	216-226
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	RUNX family transcription factor 1	Rattus norvegicus	228-233
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	KRAS proto-oncogene, GTPase	Rattus norvegicus	235-238
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	cyclin E1	Rattus norvegicus	240-249
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	251-258
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	sulfotransferase family 1E member 1	Rattus norvegicus	260-267
21251947-5	2011	In this work, we showed the in vitro inhibitory effects of BF on luteinizing hormone (LH)-inducible ovulatory gene expression in rat ovarian granulosa cells, including genes P450scc, StAR, PR, AREG, EREG, TGF-beta1, C/EBP beta, RUNX1, p21, cyclin E1, CYP19a1, SULT1E1 and PTGS2.	bifenthrin	59-61	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	272-277
21251947-7	2011	Because prostaglandins and their key synthetic enzyme PTGS2 play pivotal roles in ovulatory process, we further investigated the molecular mechanism of disruption of PTGS2 by BF.	bifenthrin	175-177	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	166-171
21251947-9	2011	Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway.	bifenthrin	70-72	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	21-26
21251947-9	2011	Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway.	bifenthrin	70-72	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	116-121
21251947-9	2011	Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway.	bifenthrin	70-72	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	145-161
21251947-9	2011	Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway.	bifenthrin	70-72	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	163-166
21251947-9	2011	Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway.	bifenthrin	90-92	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	21-26
21251947-9	2011	Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway.	bifenthrin	90-92	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	116-121
21251947-9	2011	Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway.	bifenthrin	90-92	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	145-161
21251947-9	2011	Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway.	bifenthrin	90-92	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	163-166
19833193-2	2010	This investigation was designed to examine (1) bifenthrin as an inducer of oxidative stress in human erythrocytes in vitro through effects on catalase (CAT) and superoxide dismutase (SOD) activities, and (2) the role of the flavonoids quercetin (Q, 40 and 80microM) and rutin (R, 80microM) in alleviating the effects of bifenthrin.	bifenthrin	47-57	superoxide dismutase 1	Homo sapiens	161-181
19833193-2	2010	This investigation was designed to examine (1) bifenthrin as an inducer of oxidative stress in human erythrocytes in vitro through effects on catalase (CAT) and superoxide dismutase (SOD) activities, and (2) the role of the flavonoids quercetin (Q, 40 and 80microM) and rutin (R, 80microM) in alleviating the effects of bifenthrin.	bifenthrin	47-57	superoxide dismutase 1	Homo sapiens	183-186
19249324-7	2009	Some pyrethroids such as bioresmethrin were preferably hydrolyzed by carboxylesterase HCE1, whereas others such as bifenthrin preferably by HCE2.	bifenthrin	115-125	carboxylesterase 2	Homo sapiens	140-144
19043362-9	2008	Antibody blocking studies demonstrated that bifenthrin induced CEM SS adhesion to fibronectin is mediated through alpha5beta1 integrin.	bifenthrin	44-54	fibronectin 1	Homo sapiens	82-93
17125154-0	2007	Esterase-mediated bifenthrin resistance in a multiresistant strain of the two-spotted spider mite, Tetranychus urticae.	bifenthrin	18-28	acetylcholinesterase-like	Tetranychus urticae	0-8
17125154-2	2007	The esterase inhibitor S,S,S-tributyl-phosphorotrithioate (DEF) was able strongly to synergise bifenthrin toxicity in the resistant strain.	bifenthrin	95-105	acetylcholinesterase-like	Tetranychus urticae	4-12
32900186-6	2020	Several genes predicted to be involved in apoptotic (caspase3 and nrf2) and inflammatory (miox) pathways had altered expression following exposure to bifenthrin.	bifenthrin	150-160	caspase-3b	Oncorhynchus mykiss	53-61
16501417-9	2006	The bifenthrin-induced aggregate formation, like that seen with PHA, was blocked by treating the cells with antibodies to either LFA-1 or ICAM.	bifenthrin	4-14	integrin subunit alpha L	Homo sapiens	129-134
16501417-10	2006	CONCLUSIONS: The results here show that bifenthrin activates T-cell function by stimulating ICAM/LFA-1 mediated homotypic aggregation.	bifenthrin	40-50	integrin subunit alpha L	Homo sapiens	97-102
16271832-12	2006	Expression of GRP94 was found to be increased and HSP27 lowered by the highest concentrations of bifenthrin commercial formulations.	bifenthrin	97-107	heat shock protein 90 beta family member 1	Homo sapiens	14-19
16271832-12	2006	Expression of GRP94 was found to be increased and HSP27 lowered by the highest concentrations of bifenthrin commercial formulations.	bifenthrin	97-107	heat shock protein family B (small) member 1	Homo sapiens	50-55
12020020-9	2002	The decrease in susceptibility in the O. pratensis strains exposed to bifenthrin, lambda-cyhalothrin, and dimethoate was associated with a 4.7-, 3.0-, and 3.6-fold increase in general esterase activity, respectively.	bifenthrin	70-80	acetylcholinesterase-like	Tetranychus urticae	184-192
12020020-10	2002	The decrease in susceptibility in the T. urticae strains exposed to bifenthrin and lambda-cyhalothrin was associated with a 1.3- and 1.1-fold increase in general esterase activity, respectively.	bifenthrin	68-78	acetylcholinesterase-like	Tetranychus urticae	162-170
33902677-4	2021	The aim of the article was to check if subacute poisoning with bifenthrin affects proinflammatory interleukin 1ss and tumor necrosis factoralpha (TNFalpha) in kidneys, livers and the function of these organs.	bifenthrin	63-73	tumor necrosis factor	Mus musculus	98-144
33902677-4	2021	The aim of the article was to check if subacute poisoning with bifenthrin affects proinflammatory interleukin 1ss and tumor necrosis factoralpha (TNFalpha) in kidneys, livers and the function of these organs.	bifenthrin	63-73	tumor necrosis factor	Mus musculus	146-154
32672501-0	2020	Metabolism of bifenthrin, beta-cyfluthrin, lambda-cyhalothrin, cyphenothrin and esfenvalerate by rat and human cytochrome P450 and carboxylesterase enzymes.	bifenthrin	14-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	111-147
32900186-6	2020	Several genes predicted to be involved in apoptotic (caspase3 and nrf2) and inflammatory (miox) pathways had altered expression following exposure to bifenthrin.	bifenthrin	150-160	nuclear factor erythroid 2-related factor 2a	Oncorhynchus mykiss	66-70
32900186-7	2020	There was a significantly increased expression of caspase3 and miox in fish treated with 120 ng/L bifenthrin with a significant reduction of nrf2 in fish treated with 60 ng/L bifenthrin.	bifenthrin	98-108	caspase-3b	Oncorhynchus mykiss	50-58
32900186-7	2020	There was a significantly increased expression of caspase3 and miox in fish treated with 120 ng/L bifenthrin with a significant reduction of nrf2 in fish treated with 60 ng/L bifenthrin.	bifenthrin	98-108	nuclear factor erythroid 2-related factor 2a	Oncorhynchus mykiss	141-145
32900186-7	2020	There was a significantly increased expression of caspase3 and miox in fish treated with 120 ng/L bifenthrin with a significant reduction of nrf2 in fish treated with 60 ng/L bifenthrin.	bifenthrin	175-185	nuclear factor erythroid 2-related factor 2a	Oncorhynchus mykiss	141-145
32061760-0	2020	Bifenthrin insecticide promotes oxidative stress and increases inflammatory mediators in human neuroblastoma cells through NF-kappaB pathway.	bifenthrin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	123-132
31734314-6	2020	We found that bifenthrin increased intestinal ROS accumulation and the inflammatory genes including tnfa, il6, il8 and ptgs2b, thereby increasing embryo mortality.	bifenthrin	14-24	interleukin 6 (interferon, beta 2)	Danio rerio	106-109
32061760-8	2020	There was also a BF concentration-dependent increase in oxidative stress markers (ROS release, NO, MDA and H2O2) and decrease in the activity of antioxidant enzymes (CAT and GPx activities).	bifenthrin	17-19	catalase	Homo sapiens	166-169
32061760-10	2020	Our data shows that BF induces various oxidative stress and inflammatory markers in SK-N-SH human neuroblastoma cells as well as the activation of NF-kappaBp65 signaling pathway.	bifenthrin	20-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	147-159
31734314-6	2020	We found that bifenthrin increased intestinal ROS accumulation and the inflammatory genes including tnfa, il6, il8 and ptgs2b, thereby increasing embryo mortality.	bifenthrin	14-24	chemokine (C-X-C motif) ligand 8a	Danio rerio	111-114
31734314-6	2020	We found that bifenthrin increased intestinal ROS accumulation and the inflammatory genes including tnfa, il6, il8 and ptgs2b, thereby increasing embryo mortality.	bifenthrin	14-24	prostaglandin-endoperoxide synthase 2b	Danio rerio	119-125
30948040-5	2019	The experimental limit of detections of fenpropathrin, cyhalothrin, S-fenvalerate and bifenthrin are 0.01 x 10-3, 0.006 x 10-3, 0.01 x 10-3 and 0.005 x 10-3 mg L-1, respectively.	bifenthrin	86-96	immunoglobulin kappa variable 1-16	Homo sapiens	160-163
31573616-6	2019	The minimal effective dose of BIF (3 mg/kg) affecting Tsc was similar to that found in prior studies using other testing paradigms.	bifenthrin	30-33	solute carrier family 12 member 3	Rattus norvegicus	54-57
30978409-0	2019	Repeated bifenthrin exposure alters hippocampal Nurr-1/AChE and induces depression-like behavior in adult rats.	bifenthrin	9-19	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	48-54
30978409-0	2019	Repeated bifenthrin exposure alters hippocampal Nurr-1/AChE and induces depression-like behavior in adult rats.	bifenthrin	9-19	acetylcholinesterase	Rattus norvegicus	55-59
30978409-11	2019	Also, BF exposure induced apoptosis as assessed by hippocampal Casp-3 protein levels.	bifenthrin	6-8	caspase 3	Rattus norvegicus	63-69
31791125-7	2019	Interestingly, protein hormone-sensitive lipase (HSL) and adipose triacylglyceride lipase (ATGL) were down-regulated while lipoprotein lipase (LPL) is up-regulated after bifenthrin treatment.	bifenthrin	170-180	lipase, hormone sensitive	Mus musculus	23-47
31791125-7	2019	Interestingly, protein hormone-sensitive lipase (HSL) and adipose triacylglyceride lipase (ATGL) were down-regulated while lipoprotein lipase (LPL) is up-regulated after bifenthrin treatment.	bifenthrin	170-180	patatin-like phospholipase domain containing 2	Mus musculus	91-95
31791125-7	2019	Interestingly, protein hormone-sensitive lipase (HSL) and adipose triacylglyceride lipase (ATGL) were down-regulated while lipoprotein lipase (LPL) is up-regulated after bifenthrin treatment.	bifenthrin	170-180	lipoprotein lipase	Mus musculus	123-141
31791125-7	2019	Interestingly, protein hormone-sensitive lipase (HSL) and adipose triacylglyceride lipase (ATGL) were down-regulated while lipoprotein lipase (LPL) is up-regulated after bifenthrin treatment.	bifenthrin	170-180	lipoprotein lipase	Mus musculus	143-146