PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24277094-0	1988	Plant polyphenols (syn.	Polyphenols	6-17	synemin	Homo sapiens	19-22
2553283-1	1989	New 5"-nucleotidase-inhibitory polyphenols named NPF-86IA, NPF-86IB, NPF-86IIA and NPF-86IIB were isolated from the seeds of Areca catechu L. The ability of the inhibitors to precipitate gelatin was investigated by microturbidimetry.	Polyphenols	31-42	5' nucleotidase, ecto	Mus musculus	4-19
24277094-2	1988	Many of the hypotheses adumbrated to rationalize the role of natural products in plant-herbivore interactions have focused attention on plant polyphenols (syn., vegetable tannins).	Polyphenols	142-153	synemin	Homo sapiens	155-158
526433-1	1979	Male mice of inbred strains Swiss and C17 were fed daily 5 times a week by intragastric tube 0.1 ml of betel-nut aqueous extract, betel-leaf aqueous extract and the polyphenol fraction of betel nut.	Polyphenols	165-175	NUT midline carcinoma, family member 1	Mus musculus	194-197
3032668-0	1987	Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis.	Polyphenols	39-50	NUT midline carcinoma family member 1	Homo sapiens	35-38
3926972-3	1985	Principally, the black layer on the teeth of betel chewers was identical with subgingival calculus which had been colored by specific polyphenols contained in the betel nut.	Polyphenols	134-145	NUT midline carcinoma family member 1	Homo sapiens	169-172
6089259-0	1984	[Action of low-molecular compounds of a polyphenol-quinoid nature from an irradiated organism on cytochrome C].	Polyphenols	40-50	cytochrome c, somatic	Homo sapiens	97-109
6468841-0	1984	Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion.	Polyphenols	56-67	homeobox C8	Homo sapiens	40-43
6284174-0	1982	Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols.	Polyphenols	119-130	PDLIM1 interacting kinase 1 like	Homo sapiens	79-92
7295998-2	1981	TGP-L and TGP-CSC contain polyphenol haptens that activate the factor XII (Hageman factor) dependent pathways of coagulation, fibrinolysis, and kinin generation in normal human plasma.	Polyphenols	26-36	coagulation factor XII	Homo sapiens	75-89
526433-0	1979	Carcinogenicity of betel quid ingredients: feeding mice with aqueous extract and the polyphenol fraction of betel nut.	Polyphenols	85-95	NUT midline carcinoma, family member 1	Mus musculus	114-117
752297-0	1978	[Bean broths in relation to its contents of amino acids and polyphenols].	Polyphenols	60-71	brain expressed associated with NEDD4 1	Homo sapiens	1-5
456521-0	1979	[Biological activity of a new polyphenol preparation, SPL].	Polyphenols	30-40	sphingosine-1-phosphate lyase 1	Homo sapiens	54-57
24481657-2	1972	Under a variety of cultural conditions, including variation in initial auxin and carbohydrate levels, there appears to be a close correlation between phenylalanine ammonia-lyase (PAL) activity and polyphenol synthesis, although there is some discrepancy in timing between the maximum rate of polyphenol accumulation and the period of maximum enzyme content.	Polyphenols	197-207	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	150-177
24481657-2	1972	Under a variety of cultural conditions, including variation in initial auxin and carbohydrate levels, there appears to be a close correlation between phenylalanine ammonia-lyase (PAL) activity and polyphenol synthesis, although there is some discrepancy in timing between the maximum rate of polyphenol accumulation and the period of maximum enzyme content.	Polyphenols	197-207	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	179-182
24481657-2	1972	Under a variety of cultural conditions, including variation in initial auxin and carbohydrate levels, there appears to be a close correlation between phenylalanine ammonia-lyase (PAL) activity and polyphenol synthesis, although there is some discrepancy in timing between the maximum rate of polyphenol accumulation and the period of maximum enzyme content.	Polyphenols	292-302	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	150-177
24481657-2	1972	Under a variety of cultural conditions, including variation in initial auxin and carbohydrate levels, there appears to be a close correlation between phenylalanine ammonia-lyase (PAL) activity and polyphenol synthesis, although there is some discrepancy in timing between the maximum rate of polyphenol accumulation and the period of maximum enzyme content.	Polyphenols	292-302	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	179-182
24481657-8	1972	Once the increase in PAL activity has started, the early stage of development of the enzyme is less sensitive to high hormone levels than is polyphenol synthesis.	Polyphenols	141-151	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	21-24
5142863-0	1971	[Catalytic acceleration by polyphenols and quinones of methemoglobin degradation in human erythrocytes].	Polyphenols	27-38	hemoglobin subunit gamma 2	Homo sapiens	55-68
34044827-0	2021	The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway.	Polyphenols	4-14	AKT serine/threonine kinase 1	Homo sapiens	108-111
33887419-15	2021	HPLC analysis of the AGE showed the polyphenol-rich nature of the extract.	Polyphenols	36-46	renin binding protein	Mus musculus	21-24
16657046-1	1969	The change in polyphenol content in the primed leaves of burley, flue-cured, and Turkish tobaccos during air-curing was related to the activities and isozymes of polyphenol oxidase and peroxidase.	Polyphenols	14-24	lignin-forming anionic peroxidase-like	Nicotiana tabacum	185-195
13334235-0	1956	[Polyphenols of pip fruit juices and grape juice.	Polyphenols	1-12	prolactin induced protein	Homo sapiens	16-19
33556725-3	2021	The results indicated that polyphenols inhibited the oxidative injuries of HSA in the order: Hto > Bra > Hte.	Polyphenols	27-38	albumin	Homo sapiens	75-78
33556725-5	2021	Therefore, the structure-affinity relationships of polyphenols binding to HSA were also explored.	Polyphenols	51-62	albumin	Homo sapiens	74-77
33556725-6	2021	Fluorescence experiments indicated that polyphenols bound to HSA through static quenching mechanism.	Polyphenols	40-51	albumin	Homo sapiens	61-64
33556725-7	2021	Furthermore, some conformational changes of HSA could be observed in the presence of polyphenols.	Polyphenols	85-96	albumin	Homo sapiens	44-47
33556725-8	2021	Altogether, molecular structure of polyphenols played a significant role in their protective effect against HSA oxidative damage and binding ability, which provided fundamental insights into their application as health care foods.	Polyphenols	35-46	albumin	Homo sapiens	108-111
32921322-0	2021	The Effect of Grape Products Containing Polyphenols on C-reactive protein Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.	Polyphenols	40-51	C-reactive protein	Homo sapiens	55-73
32921322-1	2021	Although grape polyphenols can decrease chronic inflammations, their effect on C-reactive protein (CRP) levels is still controversial.	Polyphenols	15-26	C-reactive protein	Homo sapiens	79-97
32921322-1	2021	Although grape polyphenols can decrease chronic inflammations, their effect on C-reactive protein (CRP) levels is still controversial.	Polyphenols	15-26	C-reactive protein	Homo sapiens	99-102
32921322-2	2021	So, this meta-analysis was conducted to investigate the effect of grape products containing polyphenols on CRP concentrations.	Polyphenols	92-103	C-reactive protein	Homo sapiens	107-110
32921322-7	2021	Based on the results, grape products containing polyphenol decreased the CRP levels significantly (SMD = -0.229; 95% CI: -0.41, -0.05; P = 0.013).	Polyphenols	48-58	C-reactive protein	Homo sapiens	73-76
32921322-9	2021	According to the subgroup analysis, higher doses of grape polyphenols (  500 mg/d) and longer intervention periods (>= 12 wk) had significant effects on CRP levels.	Polyphenols	58-69	C-reactive protein	Homo sapiens	153-156
32921322-10	2021	Furthermore, grape polyphenols significantly reduced the CRP levels in patients with a clinical condition.	Polyphenols	19-30	C-reactive protein	Homo sapiens	57-60
32921322-12	2021	According to the meta-regression results, the CRP level depends on the dose and duration of the grape polyphenols supplementation.	Polyphenols	102-113	C-reactive protein	Homo sapiens	46-49
32921322-13	2021	Based on the findings, grape products containing polyphenols had a significant effect on CRP levels.	Polyphenols	49-60	C-reactive protein	Homo sapiens	89-92
33016666-3	2021	Molecular docking studies have highlighted that quercetin, a natural polyphenol belonging to the flavonol class, inhibits 3CLpro, PLpro and S proteins.	Polyphenols	69-79	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	130-135
33687663-2	2021	It has been postulated that foods and supplements containing flavonoid polyphenols may enhance recovery from exercise-induced muscle damage (EIMD) through upregulation of cell signalling stress response pathways, particularly the nuclear factor erythroid 2-related factor 2 (NRF2) pathway.	Polyphenols	71-82	NFE2 like bZIP transcription factor 2	Homo sapiens	230-273
33687663-2	2021	It has been postulated that foods and supplements containing flavonoid polyphenols may enhance recovery from exercise-induced muscle damage (EIMD) through upregulation of cell signalling stress response pathways, particularly the nuclear factor erythroid 2-related factor 2 (NRF2) pathway.	Polyphenols	71-82	NFE2 like bZIP transcription factor 2	Homo sapiens	275-279
34051214-3	2021	This study investigated the modulation of HSP70 expression by dietary polyphenols, with particular reference to curcumin, in human intestinal Caco-2 cells.	Polyphenols	70-81	heat shock protein family A (Hsp70) member 4	Homo sapiens	42-47
34044827-0	2021	The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway.	Polyphenols	4-14	mechanistic target of rapamycin kinase	Homo sapiens	112-116
34028050-2	2021	Herein, screening and identifying of alpha-glucosidase inhibitors from hawthorn berry were conducted, and the results showed polyphenols mainly containing quercetin (74.58%) and hyperioside (9.58%) were responsible for its bioactivity.	Polyphenols	125-136	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
34046949-0	2021	Polyphenol-solubility alters amyloid fibril formation of alpha-synuclein.	Polyphenols	0-10	synuclein alpha	Homo sapiens	57-72
33979140-2	2021	Here, we have demonstrated for the first time that polyphenol oleuropein aglycone (OleA), which is the most abundant compound in olive oil, has multiple potencies for the inhibition of amyloid self-assembly of pro-inflammatory protein S100A9 and the mitigation of the damaging effect of its amyloids on neuroblastoma SH-SY5Y cells.	Polyphenols	51-61	S100 calcium binding protein A9	Homo sapiens	235-241
33998910-5	2021	There is accumulating evidence that dietary polyphenols may show therapeutic efficacy in RA through their antioxidant, anti-inflammatory, apoptotic, and immunosuppressant activities and modulation of the tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, mitogen-activated protein kinase (MAPK), IL-1beta, c-Jun N-terminal kinase (JNK), and nuclear factor kappa light-chain-enhancer of activated B cell (NF-kappaB) pathways.	Polyphenols	44-55	tumor necrosis factor	Homo sapiens	204-231
33998910-5	2021	There is accumulating evidence that dietary polyphenols may show therapeutic efficacy in RA through their antioxidant, anti-inflammatory, apoptotic, and immunosuppressant activities and modulation of the tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, mitogen-activated protein kinase (MAPK), IL-1beta, c-Jun N-terminal kinase (JNK), and nuclear factor kappa light-chain-enhancer of activated B cell (NF-kappaB) pathways.	Polyphenols	44-55	tumor necrosis factor	Homo sapiens	233-242
33998910-5	2021	There is accumulating evidence that dietary polyphenols may show therapeutic efficacy in RA through their antioxidant, anti-inflammatory, apoptotic, and immunosuppressant activities and modulation of the tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, mitogen-activated protein kinase (MAPK), IL-1beta, c-Jun N-terminal kinase (JNK), and nuclear factor kappa light-chain-enhancer of activated B cell (NF-kappaB) pathways.	Polyphenols	44-55	interleukin 6	Homo sapiens	245-263
33998910-5	2021	There is accumulating evidence that dietary polyphenols may show therapeutic efficacy in RA through their antioxidant, anti-inflammatory, apoptotic, and immunosuppressant activities and modulation of the tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, mitogen-activated protein kinase (MAPK), IL-1beta, c-Jun N-terminal kinase (JNK), and nuclear factor kappa light-chain-enhancer of activated B cell (NF-kappaB) pathways.	Polyphenols	44-55	interleukin 1 alpha	Homo sapiens	306-314
33998910-5	2021	There is accumulating evidence that dietary polyphenols may show therapeutic efficacy in RA through their antioxidant, anti-inflammatory, apoptotic, and immunosuppressant activities and modulation of the tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, mitogen-activated protein kinase (MAPK), IL-1beta, c-Jun N-terminal kinase (JNK), and nuclear factor kappa light-chain-enhancer of activated B cell (NF-kappaB) pathways.	Polyphenols	44-55	mitogen-activated protein kinase 8	Homo sapiens	316-339
33998910-5	2021	There is accumulating evidence that dietary polyphenols may show therapeutic efficacy in RA through their antioxidant, anti-inflammatory, apoptotic, and immunosuppressant activities and modulation of the tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, mitogen-activated protein kinase (MAPK), IL-1beta, c-Jun N-terminal kinase (JNK), and nuclear factor kappa light-chain-enhancer of activated B cell (NF-kappaB) pathways.	Polyphenols	44-55	mitogen-activated protein kinase 8	Homo sapiens	341-344
34018615-1	2021	BACKGROUND: Dark tea, one of the six major teas, has many biological activities, which originates from their active substrates, such as polyphenols, polysaccharide and so on.	Polyphenols	136-147	dark	Mus musculus	12-16
34015214-4	2021	Polyphenols, small molecules, synthetic peptides, and peptide-derived molecules have been considered as potential candidates that inhibit alpha-synuclein oligomerization and its fibrillation, and a few of them are in clinical trials.	Polyphenols	0-11	synuclein alpha	Homo sapiens	138-153
33925096-1	2021	Grape seeds (GS) and grape skins (GK) are natural sources of polyphenols with featured antioxidant capacity.	Polyphenols	61-72	glycerol kinase 2	Gallus gallus	34-36
33662414-4	2021	In this study, we show that fisetin, a plant-derived polyphenol compound, can inhibit aggregation of the tau fragment, K18, and can disaggregate tau K18 filaments in vitro.	Polyphenols	53-63	microtubule associated protein tau	Homo sapiens	105-108
33515684-0	2021	Polyphenol-rich extract and fractions of Terminalia phaeocarpa Eichler possess hypoglycemic effect, reduce the release of cytokines, and inhibit lipase, alpha-glucosidase, and alpha-amilase enzymes.	Polyphenols	0-10	sucrase-isomaltase	Homo sapiens	153-170
33516071-0	2021	Tea polyphenols and Levofloxacin alleviate the lung injury of hepatopulmonary syndrome in common bile duct ligation rats through Endotoxin -TNF signaling.	Polyphenols	4-15	tumor necrosis factor	Rattus norvegicus	140-143
33925096-4	2021	Feeding chickens with 110 g/kg GK reduced (p < 0.001) daily weight gain, worsened (p < 0.001) feed conversion ratio, increased (p < 0.001) non-extractable polyphenol content in the ileum and in the excreta and decreased (p < 0.05) ileal protein digestibility.	Polyphenols	155-165	glycerol kinase 2	Gallus gallus	31-33
33981700-0	2021	Tea Polyphenols Prevent Sepsis-Induced Lung Injury via Promoting Translocation of DJ-1 to Mitochondria.	Polyphenols	4-15	Parkinsonism associated deglycase	Rattus norvegicus	82-86
33922726-10	2021	The results showed that polyphenol-rich BSG fractions have potentials as natural anti-cholinesterase agents.	Polyphenols	24-34	butyrylcholinesterase	Homo sapiens	86-100
33922965-2	2021	Polyphenols from berries act by blocking digestive enzymes, reshaping gastrointestinal microbiota, and affecting the release of gastrointestinal hormones to regulate insulin dynamics and glucose management.	Polyphenols	0-11	insulin	Homo sapiens	166-173
33923263-3	2021	Polyphenols are a group of plant-derived compounds with anti-inflammatory and antioxidant properties that are associated with a low prevalence of metabolic conditions characterized by insulin resistance, including obesity, diabetes, and hypertension.	Polyphenols	0-11	insulin	Homo sapiens	184-191
33922657-3	2021	In this study, we demonstrated that curcumin, a plant polyphenol, sensitizes BRCA2-deficient cells to CPT-11 by impairing RAD52 recombinase in MCF7 cells.	Polyphenols	54-64	BRCA2 DNA repair associated	Homo sapiens	77-82
33610557-3	2021	Here we test the effects of Brazilin on both seeded and unseeded alpha-syn fibril formation and show that the natural polyphenol inhibits fibrillogenesis of alpha-syn by a unique mechanism that alters conformational equilibria in two separate points of the assembly mechanism: Brazilin preserves the natively unfolded state of alpha-syn by specifically binding to the compact conformation of the alpha-syn monomer.	Polyphenols	118-128	synuclein alpha	Homo sapiens	157-166
33871312-0	2021	Combination of tea polyphenols and proanthocyanidins prevents menopause-related memory decline in rats via increased hippocampal synaptic plasticity by inhibiting p38 MAPK and TNF-alpha pathway.	Polyphenols	19-30	tumor necrosis factor	Rattus norvegicus	176-185
33610557-3	2021	Here we test the effects of Brazilin on both seeded and unseeded alpha-syn fibril formation and show that the natural polyphenol inhibits fibrillogenesis of alpha-syn by a unique mechanism that alters conformational equilibria in two separate points of the assembly mechanism: Brazilin preserves the natively unfolded state of alpha-syn by specifically binding to the compact conformation of the alpha-syn monomer.	Polyphenols	118-128	synuclein alpha	Homo sapiens	157-166
33610557-3	2021	Here we test the effects of Brazilin on both seeded and unseeded alpha-syn fibril formation and show that the natural polyphenol inhibits fibrillogenesis of alpha-syn by a unique mechanism that alters conformational equilibria in two separate points of the assembly mechanism: Brazilin preserves the natively unfolded state of alpha-syn by specifically binding to the compact conformation of the alpha-syn monomer.	Polyphenols	118-128	synuclein alpha	Homo sapiens	157-166
33856591-3	2021	Molecular docking study using BIOVIA Discovery Studio 2018 revealed, (-)-epicatechin-3-O-gallate (ECG), a tea polyphenol has a binding affinity toward both the selected receptors, with the lowest CDocker energy - 46.22 kcal mol-1 for SARS-CoV-2 Mpro and CDocker energy - 44.72 kcal mol-1 for SARS-CoV-2 PLpro, respectively.	Polyphenols	110-120	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	245-249
33868970-9	2022	The polyphenols found in green tea can also be useful in suppressing the furin activity.	Polyphenols	4-15	furin, paired basic amino acid cleaving enzyme	Homo sapiens	73-78
33851721-0	2021	Enhancement of angiogenin inhibition by polyphenol-capped gold nanoparticles.	Polyphenols	40-50	angiogenin	Homo sapiens	15-25
33851721-4	2021	We report an inhibition of the ribonucleolytic activity of Ang with the gallate containing green tea polyphenols, ECG and EGCG that exhibits an increased efficacy upon forming polyphenol-capped gold nanoparticles (ECG-AuNPs and EGCG-AuNPs).	Polyphenols	101-112	angiogenin	Homo sapiens	59-62
33851721-4	2021	We report an inhibition of the ribonucleolytic activity of Ang with the gallate containing green tea polyphenols, ECG and EGCG that exhibits an increased efficacy upon forming polyphenol-capped gold nanoparticles (ECG-AuNPs and EGCG-AuNPs).	Polyphenols	101-111	angiogenin	Homo sapiens	59-62
33121781-4	2021	GC-MS and LC-MS analysis also showed that biomolecules presented in the green tea extract, including polyphenols and L-theanine, participated in the formation of GT-1.	Polyphenols	101-112	beta-1,4-galactosyltransferase 1	Homo sapiens	162-166
33823775-8	2021	Apart from them, natural bioactive ingredients from plants, such as flavonoids, polyphenols, alkaloids, terpenoids, polysaccharides, and quinones are efficient in helping weight loss and improving insulin sensitivity and glycemic control.	Polyphenols	80-91	insulin	Homo sapiens	197-204
33918684-7	2021	The study indicated that low molecular weight polyphenols were crucial for the protective activity of the extracts toward fibrinogen and other human plasma components.	Polyphenols	46-57	fibrinogen beta chain	Homo sapiens	122-132
33889165-0	2021	Diversity of Chemical Structures and Biosynthesis of Polyphenols in Nut-Bearing Species.	Polyphenols	53-64	NUT midline carcinoma family member 1	Homo sapiens	68-71
33889165-4	2021	Although functional elucidation of the biosynthetic genes of polyphenols in nut species is crucially important for crop improvement in the creation of higher-quality nuts and stress-tolerant cultivars, the chemical diversity of nut polyphenols and the key biosynthetic genes responsible for their production are still largely uncharacterized.	Polyphenols	61-72	NUT midline carcinoma family member 1	Homo sapiens	76-79
33889165-4	2021	Although functional elucidation of the biosynthetic genes of polyphenols in nut species is crucially important for crop improvement in the creation of higher-quality nuts and stress-tolerant cultivars, the chemical diversity of nut polyphenols and the key biosynthetic genes responsible for their production are still largely uncharacterized.	Polyphenols	61-72	NUT midline carcinoma family member 1	Homo sapiens	166-169
33889165-4	2021	Although functional elucidation of the biosynthetic genes of polyphenols in nut species is crucially important for crop improvement in the creation of higher-quality nuts and stress-tolerant cultivars, the chemical diversity of nut polyphenols and the key biosynthetic genes responsible for their production are still largely uncharacterized.	Polyphenols	232-243	NUT midline carcinoma family member 1	Homo sapiens	76-79
33889165-6	2021	Here, we review the chemical diversity of seed polyphenols in majorly consumed nut species coupled to insights into their biological activities.	Polyphenols	47-58	NUT midline carcinoma family member 1	Homo sapiens	79-82
33781769-0	2021	Oat polyphenol avenanthramide-2c confers protection from oxidative stress by regulating the Nrf2-ARE signaling pathway in PC12 cells.	Polyphenols	4-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	92-96
33100380-5	2021	Various phytochemicals, including polyphenols and alkaloids, have been proposed as potent inhibitors of Mpro.	Polyphenols	34-45	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	104-108
33918387-0	2021	Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line.	Polyphenols	61-71	tumor protein p53	Homo sapiens	100-103
32981207-0	2021	The anti-STAT1 polyphenol myricetin inhibits M1 microglia activation and counteracts neuronal death.	Polyphenols	15-25	signal transducer and activator of transcription 1	Homo sapiens	9-14
33188902-0	2021	Functional reconstitution of HBV-specific CD8 T cells by in vitro polyphenol treatment in chronic hepatitis B.	Polyphenols	66-76	CD8a molecule	Homo sapiens	42-45
33787687-1	2021	The immobilization of the enzyme tyrosinase (Tyr) in lipid matrices can be explored to produce biosensors for detecting polyphenols, which is relevant for the food industry.	Polyphenols	120-131	tyrosinase	Homo sapiens	33-43
32871358-0	2021	Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-kappaB and Nrf2 pathways.	Polyphenols	28-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
33527835-1	2021	Broussochalcones A (BCA, 1) and B (BCB, 2) are major bioactive constituents isolated from Broussonetia papyrifera, a polyphenol-rich plant belonging to the family Moraceae.	Polyphenols	117-127	B cell linker	Homo sapiens	20-23
33646787-4	2021	In the last decades, many natural compounds or derivatives have been evaluated as potential PL inhibitors, and natural polyphenols are among the most promising for possible exploitation as antiobesity agents.	Polyphenols	119-130	pancreatic lipase	Homo sapiens	92-94
33884026-0	2021	Polyphenols from Broussonetia papyrifera Induce Apoptosis of HepG2 Cells via Inactivation of ERK and AKT Signaling Pathways.	Polyphenols	0-11	mitogen-activated protein kinase 1	Homo sapiens	93-96
33884026-0	2021	Polyphenols from Broussonetia papyrifera Induce Apoptosis of HepG2 Cells via Inactivation of ERK and AKT Signaling Pathways.	Polyphenols	0-11	AKT serine/threonine kinase 1	Homo sapiens	101-104
32871358-0	2021	Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-kappaB and Nrf2 pathways.	Polyphenols	28-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
32871358-2	2021	In this study, we evaluated the underlying immunomodulatory activity of polyphenol extracts of thinned peach (PETP) via the NF-kappaB and Nrf2 signaling pathways in RAW264.7 macrophages.	Polyphenols	72-82	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	124-133
32871358-2	2021	In this study, we evaluated the underlying immunomodulatory activity of polyphenol extracts of thinned peach (PETP) via the NF-kappaB and Nrf2 signaling pathways in RAW264.7 macrophages.	Polyphenols	72-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
33596716-4	2022	This review discusses reports of modulation of the Wnt/beta-Catenin signaling pathway by dietary polyphenols (resveratrol, avenanthramides, epigallocatechinin, curcumin, quercetin, silibinin, genistein and mangiferin) specifically focusing on CRC, and proposes a model as to how this modulation occurs.	Polyphenols	97-108	catenin beta 1	Homo sapiens	55-67
33296763-5	2021	Other three humic-like components (C1, C2, C3) had positive associations with low H/C-ratio molecules (H/C < 1.2), which mainly consisted of highly unsaturated and phenolic compounds, polyphenols, and polycyclic aromatics.	Polyphenols	184-195	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	35-45
33037751-0	2021	Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.	Polyphenols	6-16	sirtuin 1	Homo sapiens	131-136
33037751-0	2021	Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.	Polyphenols	6-16	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	137-141
33641052-0	2021	New Insights into the Mechanisms of Polyphenol from Plum Fruit Inducing Apoptosis in Human Lung Cancer A549 Cells Via PI3K/AKT/FOXO1 Pathway.	Polyphenols	36-46	AKT serine/threonine kinase 1	Homo sapiens	123-126
33641052-0	2021	New Insights into the Mechanisms of Polyphenol from Plum Fruit Inducing Apoptosis in Human Lung Cancer A549 Cells Via PI3K/AKT/FOXO1 Pathway.	Polyphenols	36-46	forkhead box O1	Homo sapiens	127-132
33379009-0	2021	Dual electrophoretically-mediated microanalysis in multiple injection mode for the simultaneous determination of acetylcholinesterase and alpha-glucosidase activity applied to selected polyphenols.	Polyphenols	185-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-133
33379009-0	2021	Dual electrophoretically-mediated microanalysis in multiple injection mode for the simultaneous determination of acetylcholinesterase and alpha-glucosidase activity applied to selected polyphenols.	Polyphenols	185-196	sucrase-isomaltase	Homo sapiens	138-155
33669953-8	2021	More recently, natural polyphenols have emerged as a promising class of compounds to address P-gp linked MDR.	Polyphenols	23-34	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
33668814-5	2021	Polyphenols reduce inflammation by suppressing the pro-inflammatory cytokines in inflammatory bowel disease by inducing Treg cells in the intestine, inhibition of tumor necrosis factor-alpha (TNF-alpha) and induction of apoptosis, decreasing DNA damage.	Polyphenols	0-11	tumor necrosis factor	Homo sapiens	163-190
33668814-5	2021	Polyphenols reduce inflammation by suppressing the pro-inflammatory cytokines in inflammatory bowel disease by inducing Treg cells in the intestine, inhibition of tumor necrosis factor-alpha (TNF-alpha) and induction of apoptosis, decreasing DNA damage.	Polyphenols	0-11	tumor necrosis factor	Homo sapiens	192-201
33668814-7	2021	In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)).	Polyphenols	13-24	interleukin 6	Homo sapiens	204-217
33668814-7	2021	In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)).	Polyphenols	13-24	interleukin 6	Homo sapiens	219-223
33668814-7	2021	In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)).	Polyphenols	13-24	interleukin 1 alpha	Homo sapiens	226-230
33668814-7	2021	In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)).	Polyphenols	13-24	interferon gamma	Homo sapiens	232-248
33668814-7	2021	In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)).	Polyphenols	13-24	interferon gamma	Homo sapiens	250-259
33673390-10	2021	We note that Mediterranean diet (MedDiet) dietary polyphenols can de-regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and NF-kappaB-mediated oxidative stress, and metabolic inflammation.	Polyphenols	50-61	dual oxidase 2	Homo sapiens	78-137
33673390-10	2021	We note that Mediterranean diet (MedDiet) dietary polyphenols can de-regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and NF-kappaB-mediated oxidative stress, and metabolic inflammation.	Polyphenols	50-61	nuclear factor kappa B subunit 1	Homo sapiens	148-157
33673390-11	2021	MedDiet polyphenols are also effective in upregulating downstream effectors of several proteins, chiefly AMPK.	Polyphenols	8-19	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	105-109
33562294-5	2021	In this review, we will discuss the major mechanisms by which polyphenols mitigate HF in vitro and in vivo, including (1) reduced cardiac inflammation and oxidative stress, (2) reduced mitochondrial dysfunction, (3) improved Ca2+ homeostasis, (4) increased survival signaling, and (5) increased sirtuin 1 activity.	Polyphenols	62-73	sirtuin 1	Homo sapiens	295-304
33556119-8	2021	We found that intranasal administration of ovalbumin as the antigen, in combination with all enzymatically polymerised polyphenols used in this study, induced ovalbumin-specific mucosal IgA in the nasal cavity, bronchoalveolar lavage fluid, vaginal fluids, and systemic IgG, especially IgG1, in sera.	Polyphenols	119-130	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	159-168
33011952-0	2021	Inhibitory effect of bound polyphenol from foxtail millet bran on miR-149 methylation increases the chemosensitivity of human colorectal cancer HCT-8/Fu cells.	Polyphenols	27-37	microRNA 149	Homo sapiens	66-73
33613328-0	2021	Blueberry Polyphenol Extracts Enhance the Intestinal Antioxidant Capacity in Weaned Rats by Modulating the Nrf2-Keap1 Signal Pathway.	Polyphenols	10-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111
33613328-0	2021	Blueberry Polyphenol Extracts Enhance the Intestinal Antioxidant Capacity in Weaned Rats by Modulating the Nrf2-Keap1 Signal Pathway.	Polyphenols	10-20	Kelch-like ECH-associated protein 1	Rattus norvegicus	112-117
33038859-0	2021	Polyphenol binding disassembles glycation-modified bovine serum albumin amyloid fibrils.	Polyphenols	0-10	albumin	Homo sapiens	58-71
33546130-3	2021	Polyphenols are a group of plant-derived compounds whose anti-inflammatory and antioxidant properties are associated with a low prevalence of metabolic diseases, including obesity, hypertension, and insulin resistance.	Polyphenols	0-11	insulin	Homo sapiens	199-206
33491221-0	2021	Hawthorn polyphenols reduce high glucose-induced inflammation and apoptosis in ARPE-19 cells by regulating miR-34a/SIRT1 to reduce acetylation.	Polyphenols	9-20	microRNA 34a	Homo sapiens	107-114
33491221-0	2021	Hawthorn polyphenols reduce high glucose-induced inflammation and apoptosis in ARPE-19 cells by regulating miR-34a/SIRT1 to reduce acetylation.	Polyphenols	9-20	sirtuin 1	Homo sapiens	115-120
32891815-0	2021	Sargassum horneri (Turner) C. Agardh containing polyphenols attenuates particulate matter-induced inflammatory response by blocking TLR-mediated MYD88-dependent MAPK signaling pathway in MLE-12 cells.	Polyphenols	48-59	toll-like receptor 2	Mus musculus	132-135
33257134-12	2021	The polyphenol fraction showed a good antioxidant activity with phosphomolybdate, FRAP, DPPH, and ABTS radicals respectively.	Polyphenols	4-14	mechanistic target of rapamycin kinase	Homo sapiens	82-86
32893437-0	2021	Lychee seed polyphenol protects the blood-brain barrier through inhibiting Abeta(25-35)-induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1-mediated autophagy in bEnd.3 cells and APP/PS1 mice.	Polyphenols	12-22	NLR family, pyrin domain containing 3	Mus musculus	96-101
32893437-0	2021	Lychee seed polyphenol protects the blood-brain barrier through inhibiting Abeta(25-35)-induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1-mediated autophagy in bEnd.3 cells and APP/PS1 mice.	Polyphenols	12-22	mechanistic target of rapamycin kinase	Mus musculus	139-143
32893437-0	2021	Lychee seed polyphenol protects the blood-brain barrier through inhibiting Abeta(25-35)-induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1-mediated autophagy in bEnd.3 cells and APP/PS1 mice.	Polyphenols	12-22	unc-51 like kinase 1	Mus musculus	144-148
32893437-0	2021	Lychee seed polyphenol protects the blood-brain barrier through inhibiting Abeta(25-35)-induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1-mediated autophagy in bEnd.3 cells and APP/PS1 mice.	Polyphenols	12-22	presenilin 1	Mus musculus	192-195
32891815-0	2021	Sargassum horneri (Turner) C. Agardh containing polyphenols attenuates particulate matter-induced inflammatory response by blocking TLR-mediated MYD88-dependent MAPK signaling pathway in MLE-12 cells.	Polyphenols	48-59	myeloid differentiation primary response gene 88	Mus musculus	145-150
33573023-0	2021	Artemisia annua L. Polyphenol-Induced Cell Death Is ROS-Independently Enhanced by Inhibition of JNK in HCT116 Colorectal Cancer Cells.	Polyphenols	19-29	mitogen-activated protein kinase 8	Homo sapiens	96-99
33573023-1	2021	c-Jun N-terminal kinase (JNK) is activated by chemotherapeutic reagents including natural plant polyphenols, and cell fate is determined by activated phospho-JNK as survival or death depending on stimuli and cell types.	Polyphenols	96-107	mitogen-activated protein kinase 8	Homo sapiens	0-23
33573023-1	2021	c-Jun N-terminal kinase (JNK) is activated by chemotherapeutic reagents including natural plant polyphenols, and cell fate is determined by activated phospho-JNK as survival or death depending on stimuli and cell types.	Polyphenols	96-107	mitogen-activated protein kinase 8	Homo sapiens	25-28
33573023-2	2021	The purpose of this study was to elucidate the role of JNK on the anticancer effects of the Korean plant Artemisia annua L. (pKAL) polyphenols in p53 wild-type HCT116 human colorectal cancer cells.	Polyphenols	131-142	mitogen-activated protein kinase 8	Homo sapiens	55-58
33573023-2	2021	The purpose of this study was to elucidate the role of JNK on the anticancer effects of the Korean plant Artemisia annua L. (pKAL) polyphenols in p53 wild-type HCT116 human colorectal cancer cells.	Polyphenols	131-142	tumor protein p53	Homo sapiens	146-149
33572808-7	2021	Indeed, emerging evidence has shown that polyphenols can stimulate GLP-1 secretion, indicating that these natural compounds might exert metabolic action at least partially mediated by GLP-1.	Polyphenols	41-52	glucagon like peptide 1 receptor	Homo sapiens	67-72
33572808-7	2021	Indeed, emerging evidence has shown that polyphenols can stimulate GLP-1 secretion, indicating that these natural compounds might exert metabolic action at least partially mediated by GLP-1.	Polyphenols	41-52	glucagon like peptide 1 receptor	Homo sapiens	184-189
33572808-8	2021	This review provides an overview of nutritional regulation of GLP-1 secretion and summarizes recent studies on the roles of polyphenols in GLP-1 secretion and degradation as it relates to metabolic homeostasis.	Polyphenols	124-135	glucagon like peptide 1 receptor	Homo sapiens	139-144
33572808-9	2021	In addition, the effects of polyphenols on microbiota and microbial metabolites that could indirectly modulate GLP-1 secretion are also discussed.	Polyphenols	28-39	glucagon like peptide 1 receptor	Homo sapiens	111-116
33459059-0	2022	Insight into the alpha-glucosidase-inhibiting mechanism of beta-PGG, a commonly occurring polyphenol in diets.	Polyphenols	90-100	sucrase-isomaltase	Homo sapiens	17-34
33573178-9	2021	Both of the polyphenols increased insulin-stimulated glycogen synthesis and reduced lactate production in human myotubes.	Polyphenols	12-23	insulin	Homo sapiens	34-41
33573189-7	2021	Interestingly, polyphenols improved PPARgamma gene expression lowered by high glucose.	Polyphenols	15-26	peroxisome proliferator activated receptor gamma	Mus musculus	36-45
33573189-8	2021	Moreover, polyphenols were detected at the intracellular level or membrane-bound to cells, with evidence for breast cancer resistance protein (BCRP) efflux transporter role.	Polyphenols	10-21	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	109-141
33573189-8	2021	Moreover, polyphenols were detected at the intracellular level or membrane-bound to cells, with evidence for breast cancer resistance protein (BCRP) efflux transporter role.	Polyphenols	10-21	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	143-147
33573212-4	2021	The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed.	Polyphenols	73-84	sirtuin 1	Homo sapiens	27-32
33530554-6	2021	Moreover, polyphenols could modulate microbiota composition, inhibit the NF-kappaB pathway, lower IL-6, and upregulate antioxidant enzymes.	Polyphenols	10-21	nuclear factor kappa B subunit 1	Homo sapiens	73-82
33530554-6	2021	Moreover, polyphenols could modulate microbiota composition, inhibit the NF-kappaB pathway, lower IL-6, and upregulate antioxidant enzymes.	Polyphenols	10-21	interleukin 6	Homo sapiens	98-102
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Polyphenols	145-156	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	187-188
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Polyphenols	145-156	angiotensin converting enzyme 2	Homo sapiens	197-201
33553895-0	2021	Coffee Bean Polyphenols Can Form Biocompatible Template-free Antioxidant Nanoparticles with Various Sizes and Distinct Colors.	Polyphenols	12-23	brain expressed associated with NEDD4 1	Homo sapiens	7-11
33553895-2	2021	The aim of this study was to investigate whether coffee bean aqueous extracts, which are known to be rich in polyphenols, could serve as a natural source of NP building blocks.	Polyphenols	109-120	brain expressed associated with NEDD4 1	Homo sapiens	56-60
33585534-0	2020	Protective Effect of Lemon Peel Polyphenols on Oxidative Stress-Induced Damage to Human Keratinocyte HaCaT Cells Through Activation of the Nrf2/HO-1 Signaling Pathway.	Polyphenols	32-43	NFE2 like bZIP transcription factor 2	Homo sapiens	139-143
33585534-0	2020	Protective Effect of Lemon Peel Polyphenols on Oxidative Stress-Induced Damage to Human Keratinocyte HaCaT Cells Through Activation of the Nrf2/HO-1 Signaling Pathway.	Polyphenols	32-43	heme oxygenase 1	Homo sapiens	144-148
33494132-0	2021	Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?	Polyphenols	107-117	fatty acid desaturase 2	Homo sapiens	11-16
33382620-0	2021	Arecanut (Areca catechu L.) Seed Polyphenol-Ameliorated Osteoporosis by Altering Gut Microbiome via LYZ and the Immune System in Estrogen-Deficient Rats.	Polyphenols	33-43	lysozyme 2	Rattus norvegicus	100-103
33494132-1	2021	Dietary polyphenols promote cardiometabolic health and are linked with long-chain polyunsaturated fatty acids in plasma phospholipids (LC-PUFA).	Polyphenols	8-19	pumilio RNA binding family member 3	Homo sapiens	138-142
33494132-9	2021	Our results indicate the interaction between FADS2, fatty acid metabolism, and polyphenol intake in overweight subjects.	Polyphenols	79-89	fatty acid desaturase 2	Homo sapiens	45-50
33505586-0	2021	Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway.	Polyphenols	4-14	Kelch-like ECH-associated protein 1	Rattus norvegicus	106-111
33427118-6	2021	There are also strong indications that polyphenols tend to have a positive effect on BDNF concentrations.	Polyphenols	39-50	brain derived neurotrophic factor	Homo sapiens	85-89
33427118-7	2021	Four of the 11 included studies with a polyphenol intervention showed a significant increase in BDNF concentrations, one study showed an increase but this was not statistically analyzed, and two studies showed a trend to an increase.	Polyphenols	39-49	brain derived neurotrophic factor	Homo sapiens	96-100
33295908-0	2021	The galloyl moiety enhances the inhibitory activity of catechins and theaflavins against alpha-glucosidase by increasing the polyphenol-enzyme binding interactions.	Polyphenols	125-135	sucrase-isomaltase	Homo sapiens	89-106
33295908-1	2021	The inhibition properties of 10 tea polyphenols against alpha-glucosidase were studied through inhibition assay, inhibition kinetics, fluorescence quenching and molecular docking.	Polyphenols	36-47	sucrase-isomaltase	Homo sapiens	56-73
33295908-4	2021	The positive linear correlations among the constants characterizing the inhibitory activity and binding affinity of tea polyphenols to alpha-glucosidase indicate that enzyme inhibition by polyphenols is caused by the binding interactions between them, and that the combination of the characterization methods for polyphenol-glucosidase binding is reasonable.	Polyphenols	120-131	sucrase-isomaltase	Homo sapiens	135-152
33295908-4	2021	The positive linear correlations among the constants characterizing the inhibitory activity and binding affinity of tea polyphenols to alpha-glucosidase indicate that enzyme inhibition by polyphenols is caused by the binding interactions between them, and that the combination of the characterization methods for polyphenol-glucosidase binding is reasonable.	Polyphenols	188-199	sucrase-isomaltase	Homo sapiens	135-152
33295908-4	2021	The positive linear correlations among the constants characterizing the inhibitory activity and binding affinity of tea polyphenols to alpha-glucosidase indicate that enzyme inhibition by polyphenols is caused by the binding interactions between them, and that the combination of the characterization methods for polyphenol-glucosidase binding is reasonable.	Polyphenols	120-130	sucrase-isomaltase	Homo sapiens	135-152
33505586-0	2021	Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway.	Polyphenols	4-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	112-116
33682692-4	2021	OBJECTIVE: The goal of this research is to assess the effect of the vitamin A derivative all-trans retinoic acid (RA) and polyphenol pentagalloyl glucose (PGG) on the expression of elastin in human aortic smooth muscle cells (hASMC).	Polyphenols	122-132	elastin	Homo sapiens	181-188
33188406-0	2021	Combined Broccoli Sprouts and Green Tea Polyphenols Contribute to the Prevention of Estrogen Receptor-Negative Mammary Cancer via Cell Cycle Arrest and Inducing Apoptosis in HER2/neu Mice.	Polyphenols	40-51	estrogen receptor 1 (alpha)	Mus musculus	84-101
33188406-0	2021	Combined Broccoli Sprouts and Green Tea Polyphenols Contribute to the Prevention of Estrogen Receptor-Negative Mammary Cancer via Cell Cycle Arrest and Inducing Apoptosis in HER2/neu Mice.	Polyphenols	40-51	erb-b2 receptor tyrosine kinase 2	Mus musculus	174-178
32043360-5	2021	Polyphenols also influence protein biosynthesis, change metabolic processes in bacteria cells and inhibit ATP and DNA synthesis (suppressing DNA gyrase).	Polyphenols	0-11	DNA topoisomerase II alpha	Homo sapiens	141-151
33840685-0	2021	The diversity in sensitivity of TRPA1 and TRPV1 of various animals to polyphenols.	Polyphenols	70-81	transient receptor potential cation channel subfamily A member 1	Homo sapiens	32-37
33840685-0	2021	The diversity in sensitivity of TRPA1 and TRPV1 of various animals to polyphenols.	Polyphenols	70-81	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
33840685-3	2021	Here, we investigated and compared the sensitivity of TRPA1 and TRPV1 from various animals to astringent polyphenols.	Polyphenols	105-116	transient receptor potential cation channel subfamily A member 1	Homo sapiens	54-59
33840685-3	2021	Here, we investigated and compared the sensitivity of TRPA1 and TRPV1 from various animals to astringent polyphenols.	Polyphenols	105-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-69
33840685-7	2021	Mammalian TRPs showed relatively higher sensitivity to polyphenols, and especially, human TRPA1 and TRPV1 could be activated by all of three polyphenols at 20 muM.	Polyphenols	55-66	transient receptor potential cation channel subfamily A member 1	Homo sapiens	90-95
33840685-7	2021	Mammalian TRPs showed relatively higher sensitivity to polyphenols, and especially, human TRPA1 and TRPV1 could be activated by all of three polyphenols at 20 muM.	Polyphenols	55-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
33840685-7	2021	Mammalian TRPs showed relatively higher sensitivity to polyphenols, and especially, human TRPA1 and TRPV1 could be activated by all of three polyphenols at 20 muM.	Polyphenols	141-152	transient receptor potential cation channel subfamily A member 1	Homo sapiens	90-95
33840685-7	2021	Mammalian TRPs showed relatively higher sensitivity to polyphenols, and especially, human TRPA1 and TRPV1 could be activated by all of three polyphenols at 20 muM.	Polyphenols	141-152	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
33840685-9	2021	Moreover, the polyphenol-sensitivity of zebrafish TRPA1 and TRPV1 was quite different from that of medaka TRP channels.	Polyphenols	14-24	transient receptor potential cation channel, subfamily A, member 1a	Danio rerio	50-55
33840685-9	2021	Moreover, the polyphenol-sensitivity of zebrafish TRPA1 and TRPV1 was quite different from that of medaka TRP channels.	Polyphenols	14-24	transient receptor potential cation channel, subfamily V, member 1	Danio rerio	60-65
33270240-2	2021	AEG showed antioxidant activity in the DPPH  scavenging (IC50  = 17.00 +- 1.00 microg/ml) and HPLC analysis revealed that this extract is constituted by antioxidants (caffeine, catechins, theobromine, and polyphenols).	Polyphenols	205-216	cysteine-rich secretory protein 3	Rattus norvegicus	0-3
33213314-0	2021	Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-kappaB to Halt Alzheimer"s Disease.	Polyphenols	36-47	nuclear factor kappa B subunit 1	Homo sapiens	62-71
33213314-9	2021	This review represents the anti-neuroinflammatory potential of polyphenols as inhibitors of NF-kappaB to combat AD pathogenesis.	Polyphenols	63-74	nuclear factor kappa B subunit 1	Homo sapiens	92-101
32532192-0	2021	Lignans and polyphenols of Phyllanthus amarus Schumach & Thonn induce apoptosis in HCT116 human colon cancer cells through caspases-dependent pathway.	Polyphenols	12-23	caspase 8	Homo sapiens	123-131
32167433-1	2021	BACKGROUND: Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia cultivar), to peripheral lymphomonocytes from patients affected by allergic contact dermatitis (ACD) to nickel (Ni) could reduce release of pro-inflammatory cytokines and nitric oxide (NO), while increasing levels of interleukin (IL)-10, an anti-inflammatory cytokine.	Polyphenols	80-91	interleukin 10	Homo sapiens	359-378
33396696-8	2020	The green tea-derived polyphenol, (-)-epigallocatechin-3-gallate (EGCG), was previously shown to bind RPSA.	Polyphenols	22-32	ribosomal protein SA	Mus musculus	102-106
33382006-5	2021	Furthermore, we present several lines of investigation, including a few studies conducted by our team, suggesting that FGF21 expression and function can be regulated by dietary polyphenol interventions.	Polyphenols	177-187	fibroblast growth factor 21	Homo sapiens	119-124
32441185-5	2021	After a primary screening of 267 natural products, two hits, Astragalus polyphenols and 6-shogaol, were identified to promote the activity of the IFN-gamma promoter and subsequently validated by the flow cytometry assay.	Polyphenols	72-83	interferon gamma	Homo sapiens	146-155
32441185-6	2021	Obviously, both Astragalus polyphenols and 6-shogaol exhibited potential to induce the transcription and expression of IFN-gamma in a dose-dependent manner.	Polyphenols	27-38	interferon gamma	Homo sapiens	119-128
33390126-14	2021	The findings from various studies demonstrated that polyphenol-nanoformulations accelerated the apoptosis in CRC cells by upregulating the levels of caspases and Bax, whereas inhibiting the CRC cell proliferation by dowregulating the expression of Bcl-2 and ERK1/2.	Polyphenols	52-62	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165
33390126-14	2021	The findings from various studies demonstrated that polyphenol-nanoformulations accelerated the apoptosis in CRC cells by upregulating the levels of caspases and Bax, whereas inhibiting the CRC cell proliferation by dowregulating the expression of Bcl-2 and ERK1/2.	Polyphenols	52-62	BCL2 apoptosis regulator	Homo sapiens	248-253
33390126-14	2021	The findings from various studies demonstrated that polyphenol-nanoformulations accelerated the apoptosis in CRC cells by upregulating the levels of caspases and Bax, whereas inhibiting the CRC cell proliferation by dowregulating the expression of Bcl-2 and ERK1/2.	Polyphenols	52-62	mitogen-activated protein kinase 3	Homo sapiens	258-264
33035897-7	2020	Remarkably, the analytical exploitability of the approach was demonstrated by detection of the hydrogen peroxide released from HeLa cells stimulated with N-Formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) and after pretreatment of the cells with cocoa polyphenols, that induced a decreased oxidative stress levels.	Polyphenols	254-265	formyl peptide receptor 1	Homo sapiens	201-205
33375450-6	2020	The results show that long-term intake of polyphenol-enriched diet improves memory and learning, correlating with restoration of brain monoaminergic neurotransmitters and hippocampal SIRT1 levels in aged rats.	Polyphenols	42-52	sirtuin 1	Rattus norvegicus	183-188
33425912-2	2020	We previously demonstrated that green tea polyphenol EGCG had potent anti-tumor effect in bladder cancer via down regulation of NF-kappaB.	Polyphenols	42-52	nuclear factor kappa B subunit 1	Homo sapiens	128-137
33443209-5	2020	Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146.	Polyphenols	103-113	AKT serine/threonine kinase 1	Homo sapiens	37-41
33443209-5	2020	Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146.	Polyphenols	103-113	AKT serine/threonine kinase 1	Homo sapiens	145-149
33443209-5	2020	Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146.	Polyphenols	103-113	cAMP responsive element binding protein 1	Homo sapiens	166-170
33443209-5	2020	Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146.	Polyphenols	103-113	ring finger protein 146	Homo sapiens	253-259
33331220-0	2020	Two polyphenols with diverse mechanisms towards amyloidosis: differential modulation of the fibrillation pathway of human lysozyme by curcumin and EGCG.	Polyphenols	4-15	lysozyme	Homo sapiens	122-130
33185419-0	2020	Polyphenol Honokiol and Flavone 2",3",4"-Trihydroxyflavone Differentially Interact with alpha-Synuclein at Distinct Phases of Aggregation.	Polyphenols	0-10	synuclein alpha	Homo sapiens	88-103
33185419-4	2020	This study comprehensively assesses the inhibitory properties of two small molecules, the lignan polyphenol honokiol and the flavonoid 2",3",4"-trihydroxyflavone, in preventing alpha-synuclein fibrilization.	Polyphenols	97-107	synuclein alpha	Homo sapiens	177-192
33186020-3	2020	Experimental studies reported that epigallocatechin gallate (EGCG), a polyphenol extracted from green tea, can disrupt alpha-syn fibrils into benign amorphous aggregates.	Polyphenols	70-80	synuclein alpha	Homo sapiens	119-128
33372886-8	2021	Polyphenols are endowed with anti-oxidant and anti-inflammatory activity in view of their property to inhibit NF-kappaB activation, to induce the anti-inflammatory T regulatory cells and to normalize the intestinal microbiota.	Polyphenols	0-11	nuclear factor kappa B subunit 1	Homo sapiens	110-119
33388204-0	2021	A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial.	Polyphenols	2-12	haptoglobin	Homo sapiens	87-94
33388204-4	2021	The trial aimed to test the hypothesis that a polyphenol-rich dietary pattern can decrease serum zonulin levels, an IP surrogate marker involved in tight junction modulation, and can beneficially alter the intestinal microbiota, and IP-associated biochemical and clinical markers in older subjects.	Polyphenols	46-56	haptoglobin	Homo sapiens	97-104
33185223-3	2020	In this study, we found that teadenol A, a polyphenol recently isolated from Japanese post-fermented tea, acts as a novel ligand on a long-chain fatty acid receptor, GPR120.	Polyphenols	43-53	free fatty acid receptor 4	Homo sapiens	166-172
33747527-0	2021	Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3.	Polyphenols	4-14	signal transducer and activator of transcription 3	Homo sapiens	103-108
32673948-1	2020	A new kind of multi-component membrane was prepared by combining gelatin solution, porogen and an inclusion complex of ionic liquid (IL) and beta-cyclodextrin (beta-CD) in a simple physical manner for selective separation of tea polyphenols (TPs) from green tea crude extracts.	Polyphenols	229-240	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	160-167
33292085-5	2022	Previously, it has been shown experimentally that eight polyphenols derived from the root of Isatis indigotica show inhibitory effect on the cleavage/catalytic activity of the SARS CoV-1 Mpro.	Polyphenols	56-67	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	187-191
33292085-6	2022	But whether these polyphenols exhibit any inhibitory effect on SARS CoV-2 Mpro is unclear.	Polyphenols	18-29	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	74-78
33292085-11	2022	Molecular dynamics studies further revealed that these two Mpro-polyphenol complexes are more stable and experience less conformational fluctuations than Mpro-N3/lopinavir complex.	Polyphenols	64-74	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	59-63
33292085-14	2022	As a whole, our study revealed that these two polyphenols may be potent SARS CoV-2 Mpro inhibitors and may possibly be considered for COVID-19 treatment.	Polyphenols	46-57	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	83-87
33302345-6	2020	Mechanistic studies revealed that the polyphenol protects beta-cells against ER-stress mediated dysfunctions, modulating the activation of the protein kinase RNA-like endoplasmic reticulum kinase (PERK) branch of the unfolded protein response and promoting mitochondrial dynamics.	Polyphenols	38-48	epiregulin	Homo sapiens	77-79
33302345-6	2020	Mechanistic studies revealed that the polyphenol protects beta-cells against ER-stress mediated dysfunctions, modulating the activation of the protein kinase RNA-like endoplasmic reticulum kinase (PERK) branch of the unfolded protein response and promoting mitochondrial dynamics.	Polyphenols	38-48	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	143-195
33302345-6	2020	Mechanistic studies revealed that the polyphenol protects beta-cells against ER-stress mediated dysfunctions, modulating the activation of the protein kinase RNA-like endoplasmic reticulum kinase (PERK) branch of the unfolded protein response and promoting mitochondrial dynamics.	Polyphenols	38-48	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	197-201
33297377-0	2020	p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells.	Polyphenols	32-43	tumor protein p53	Homo sapiens	0-3
33297377-0	2020	p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells.	Polyphenols	32-43	tumor protein p53	Homo sapiens	87-90
33297377-0	2020	p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells.	Polyphenols	32-43	lamin A/C	Homo sapiens	135-144
33297377-2	2020	The aim of this study was to investigate the role of p53 on the anticancer effect of polyphenols isolated from Korean Artemisia annua L. (pKAL) in HCT116 human colorectal cancer cells.	Polyphenols	85-96	tumor protein p53	Homo sapiens	53-56
33011160-3	2020	Rosmarinic acid is a polyphenol with antioxidant, anti-inflammatory and insulin-sensitizing effects.	Polyphenols	21-31	insulin	Homo sapiens	72-79
33010255-5	2020	The present study was undertaken to elucidate whether the NAD-dependent protein deacetylase sirtuin isoform SIRT1 is an upstream mediator of hypoxic PC-induced protection, and to assess the efficacy of the SIRT1-activating polyphenol Resveratrol as a pharmacologic preconditioning therapy.	Polyphenols	223-233	sirtuin 1	Mus musculus	108-113
33010255-5	2020	The present study was undertaken to elucidate whether the NAD-dependent protein deacetylase sirtuin isoform SIRT1 is an upstream mediator of hypoxic PC-induced protection, and to assess the efficacy of the SIRT1-activating polyphenol Resveratrol as a pharmacologic preconditioning therapy.	Polyphenols	223-233	sirtuin 1	Mus musculus	206-211
32898539-0	2020	Polyphenols redirects the self-assembly of serum albumin into hybrid nanostructures.	Polyphenols	0-11	albumin	Homo sapiens	43-56
33128352-11	2020	Therefore, we identified TA from natural polyphenols as a novel inhibitor of PDI function.	Polyphenols	41-52	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	77-80
33128352-2	2020	In this study, we reported that a PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI activity, platelet activation and thrombus formation.	Polyphenols	52-62	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	34-37
33256066-0	2020	Olive Leaf Polyphenols (OLPs) Stimulate GLUT4 Expression and Translocation in the Skeletal Muscle of Diabetic Rats.	Polyphenols	11-22	solute carrier family 2 member 4	Rattus norvegicus	40-45
33128352-2	2020	In this study, we reported that a PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI activity, platelet activation and thrombus formation.	Polyphenols	52-62	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	91-94
33128352-3	2020	Molecular docking using plant polyphenols from dietary sources with cardiovascular benefits revealed TA as the most potent binding molecule with PDI active centre.	Polyphenols	30-41	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	145-148
33261062-4	2020	Specifically, polyphenols, widely spread in vegetables and fruits, significantly modulate adipose tissue activities, contrasting inflammation and improving insulin sensitivity in preclinical and clinical studies.	Polyphenols	14-25	insulin	Homo sapiens	156-163
33260857-2	2020	Previous studies have shown that resveratrol, a polyphenol of grapevines, can prevent VEGF secretion induced by stress from retinal cells.	Polyphenols	48-58	vascular endothelial growth factor A	Homo sapiens	86-90
33520293-0	2020	Polyphenols Extracted from Chinese Hickory (Carya cathayensis) Promote Apoptosis and Inhibit Proliferation through the p53-Dependent Intrinsic and HIF-1alpha-VEGF Pathways in Ovarian Cancer Cells.	Polyphenols	0-11	vascular endothelial growth factor A	Homo sapiens	158-162
32593042-3	2020	Enzyme-linked immunosorbent assay revealed that the covalent conjugation of dietary polyphenols significantly reduced the IgE binding capacity of Ara h1.	Polyphenols	84-95	allergen Ara h 1, clone P17	Arachis hypogaea	146-152
32593042-4	2020	Covalent binding of dietary polyphenols with Ara h1 reduced histamine release by 40% in basophils.	Polyphenols	28-39	allergen Ara h 1, clone P17	Arachis hypogaea	45-51
32593042-6	2020	The IgE epitope of Ara h1 might be blocked by polyphenols at the binding site.	Polyphenols	46-57	allergen Ara h 1, clone P17	Arachis hypogaea	19-25
32593042-7	2020	Analysis of pepsin digestion of Ara h1-polyphenol conjugates indicated that the covalent binding increased pepsin digestibility and reduced IgE binding capacity.	Polyphenols	39-49	allergen Ara h 1, clone P17	Arachis hypogaea	32-38
32593042-8	2020	Furthermore, covalent conjugation of Ara h1 with polyphenols decreased denaturation temperature and increased antioxidant activity.	Polyphenols	49-60	allergen Ara h 1, clone P17	Arachis hypogaea	37-43
32593042-9	2020	Ara h1 conjugated with polyphenols may be a promising approach for reducing the allergenicity of Ara h1.	Polyphenols	23-34	allergen Ara h 1, clone P17	Arachis hypogaea	0-6
32593042-9	2020	Ara h1 conjugated with polyphenols may be a promising approach for reducing the allergenicity of Ara h1.	Polyphenols	23-34	allergen Ara h 1, clone P17	Arachis hypogaea	97-103
33038311-2	2020	We analyzed and discovered a novel mechanism by which epigallocatechin gallate (EGCG), the most abundant polyphenol in tea and a putative health-promoting constituent, inhibits activation of the nuclear transcription factor NF-kappaB, which mediates inflammatory responses to cytokines and other agents.	Polyphenols	105-115	nuclear factor kappa B subunit 1	Homo sapiens	224-233
33261005-9	2020	Polyphenol compounds can activate Nrf2 and inhibit MMP-9.	Polyphenols	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
33261005-9	2020	Polyphenol compounds can activate Nrf2 and inhibit MMP-9.	Polyphenols	0-10	matrix metallopeptidase 9	Homo sapiens	51-56
33312423-8	2020	Among different polyphenols, highly potent compounds were screened using molecular modeling approaches and consequently the most active compound was further evaluated against HCV NS4A-NS3 protease domain using FRET assay.	Polyphenols	16-27	KRAS proto-oncogene, GTPase	Homo sapiens	184-187
33207644-5	2020	C57BL/6 mice were given a dietary supplement containing grape polyphenol concentrate (GPC-1.5 mL/kg/day) with drinking water from the age of 6-8 weeks for life.	Polyphenols	62-72	glypican 1	Mus musculus	86-91
33179911-3	2020	The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3",4"-hydroxylation inhibit recombinant human (rh)ACE2 activity.	Polyphenols	69-80	angiotensin converting enzyme 2	Homo sapiens	143-147
33273950-0	2020	Green Tea Polyphenols Protect against Acetaminophen-Induced Liver Injury by Regulating the Drug Metabolizing Enzymes and Transporters.	Polyphenols	10-21	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
33273950-1	2020	Green tea polyphenols (GTPs) have been shown to exhibit diverse beneficial effects against a variety of diseases.	Polyphenols	10-21	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
33191444-2	2020	This toxic polyphenol (PPT) exhibited significant activity against P-glycoprotein (P-gp) mediated multidrug-resistant (MDR) cancer cells.	Polyphenols	11-21	ATP binding cassette subfamily B member 1	Homo sapiens	67-81
33191444-2	2020	This toxic polyphenol (PPT) exhibited significant activity against P-glycoprotein (P-gp) mediated multidrug-resistant (MDR) cancer cells.	Polyphenols	11-21	ATP binding cassette subfamily B member 1	Homo sapiens	83-87
32942157-0	2020	Inhibitory effects of polyphenols and their colonic metabolites on CYP2D6 enzyme using two different substrates.	Polyphenols	22-33	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	67-73
33198105-7	2020	Assessment of polyphenol oxidase activity (PPO), 14 days after dipping treatment, suggests that neither direct induction nor priming of plant defenses are involved.	Polyphenols	14-24	protoporphyrinogen oxidase	Homo sapiens	43-46
33240108-0	2020	Grape Seed Extract Polyphenols Improve Resistance Artery Function in Pregnant eNOS-/- Mice.	Polyphenols	19-30	nitric oxide synthase 3, endothelial cell	Mus musculus	78-82
33135678-0	2020	Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction.	Polyphenols	36-47	insulin	Homo sapiens	0-7
32905943-3	2020	In this study, we explored the effects of Galloflavin and Ellagic acid, the most common polyphenols in berries, on SIRT6.	Polyphenols	88-99	sirtuin 6	Homo sapiens	115-120
32942157-8	2020	Our results demonstrate that some polyphenols and colonic metabolites are inhibitors of CYP2D6-catalyzed reactions.	Polyphenols	34-45	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	88-94
33293765-0	2020	Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-gamma and SOCS1 induction.	Polyphenols	7-17	signal transducer and activator of transcription 3	Homo sapiens	63-71
33152943-0	2020	The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling.	Polyphenols	117-128	adiponectin, C1Q and collagen domain containing	Homo sapiens	150-161
33152943-7	2020	While currently used therapies show limited efficacy in this aspect, accumulating evidence suggest that various dietary polyphenols may stimulate adiponectin levels, offering potential protection against the development of insulin resistance, inflammation and NAFLD as well as associated conditions of metabolic syndrome.	Polyphenols	120-131	adiponectin, C1Q and collagen domain containing	Homo sapiens	146-157
33152943-7	2020	While currently used therapies show limited efficacy in this aspect, accumulating evidence suggest that various dietary polyphenols may stimulate adiponectin levels, offering potential protection against the development of insulin resistance, inflammation and NAFLD as well as associated conditions of metabolic syndrome.	Polyphenols	120-131	insulin	Homo sapiens	223-230
33152943-8	2020	As such, this review provides a better understanding of the role polyphenols play in modulating adiponectin signaling to protect against NAFLD.	Polyphenols	65-76	adiponectin, C1Q and collagen domain containing	Homo sapiens	96-107
32852592-2	2020	In this study, we investigated the anti-STAT3 mechanism of the dietary polyphenol, biochanin A (BCA), in IL-6-treated macrophages.	Polyphenols	71-81	signal transducer and activator of transcription 3	Homo sapiens	40-45
32852592-2	2020	In this study, we investigated the anti-STAT3 mechanism of the dietary polyphenol, biochanin A (BCA), in IL-6-treated macrophages.	Polyphenols	71-81	B cell linker	Homo sapiens	83-94
32852592-2	2020	In this study, we investigated the anti-STAT3 mechanism of the dietary polyphenol, biochanin A (BCA), in IL-6-treated macrophages.	Polyphenols	71-81	B cell linker	Homo sapiens	96-99
32852592-2	2020	In this study, we investigated the anti-STAT3 mechanism of the dietary polyphenol, biochanin A (BCA), in IL-6-treated macrophages.	Polyphenols	71-81	interleukin 6	Homo sapiens	105-109
31943177-2	2020	Our previous studies showed that CTR1 expression was upregulated by (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, therefore enhanced cisplatin sensitivity in ovary cancer and non-small-cell lung cancer (NSCLC) cells.	Polyphenols	119-129	solute carrier family 31, member 1	Mus musculus	33-37
32758584-0	2020	The effect of three polyphenols and some other anti-oxidant substances on amyloid fibril formation by human cystatin C.	Polyphenols	20-31	cystatin C	Homo sapiens	108-118
33293765-0	2020	Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-gamma and SOCS1 induction.	Polyphenols	7-17	peroxisome proliferator activated receptor gamma	Homo sapiens	113-123
33293765-0	2020	Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-gamma and SOCS1 induction.	Polyphenols	7-17	suppressor of cytokine signaling 1	Homo sapiens	128-133
33293765-3	2020	Fresh walnut polyphenol extracts (WPE) were found to suppress the phosphorylation and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) induced by H. pylori infection in RGM-1 gastric mucosal cells.	Polyphenols	13-23	signal transducer and activator of transcription 3	Homo sapiens	111-161
33293765-3	2020	Fresh walnut polyphenol extracts (WPE) were found to suppress the phosphorylation and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) induced by H. pylori infection in RGM-1 gastric mucosal cells.	Polyphenols	13-23	signal transducer and activator of transcription 3	Homo sapiens	163-168
32645737-0	2020	Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice.	Polyphenols	11-22	brain expressed, associated with Nedd4, 1	Mus musculus	6-10
32645737-2	2020	Cacao bean polyphenols have recently gained considerable attention for their beneficial effects on cardiovascular diseases.	Polyphenols	11-22	brain expressed, associated with Nedd4, 1	Mus musculus	6-10
32645737-4	2020	Cardiomyocytes from neonatal rats were pre-treated with cacao bean polyphenols and then stimulated with 30 microM phenylephrine.	Polyphenols	67-78	brain expressed, associated with NEDD4, 1	Rattus norvegicus	62-66
32645737-7	2020	In cardiomyocytes, cacao bean polyphenols significantly suppressed phenylephrine-induced cardiomyocyte hypertrophy and hypertrophic gene transcription.	Polyphenols	30-41	brain expressed, associated with Nedd4, 1	Mus musculus	25-29
32645737-8	2020	Extracellular signal-regulated kinase 1/2 and GATA binding protein 4 phosphorylation induced by phenylephrine was inhibited by cacao bean polyphenols treatment in the cardiomyocytes.	Polyphenols	138-149	mitogen-activated protein kinase 3	Mus musculus	0-41
32645737-8	2020	Extracellular signal-regulated kinase 1/2 and GATA binding protein 4 phosphorylation induced by phenylephrine was inhibited by cacao bean polyphenols treatment in the cardiomyocytes.	Polyphenols	138-149	GATA binding protein 4	Mus musculus	46-68
32645737-8	2020	Extracellular signal-regulated kinase 1/2 and GATA binding protein 4 phosphorylation induced by phenylephrine was inhibited by cacao bean polyphenols treatment in the cardiomyocytes.	Polyphenols	138-149	brain expressed, associated with Nedd4, 1	Mus musculus	133-137
32645737-9	2020	Cacao bean polyphenols treatment at 1200 mg/kg significantly ameliorated left ventricular posterior wall thickness, fractional shortening, hypertrophic gene transcription, cardiac hypertrophy, cardiac fibrosis, and extracellular signal-regulated kinase 1/2 phosphorylation induced by pressure overload.	Polyphenols	11-22	brain expressed, associated with Nedd4, 1	Mus musculus	6-10
32645737-9	2020	Cacao bean polyphenols treatment at 1200 mg/kg significantly ameliorated left ventricular posterior wall thickness, fractional shortening, hypertrophic gene transcription, cardiac hypertrophy, cardiac fibrosis, and extracellular signal-regulated kinase 1/2 phosphorylation induced by pressure overload.	Polyphenols	11-22	mitogen-activated protein kinase 3	Mus musculus	215-256
32645737-10	2020	In conclusion, these findings suggest that cacao bean polyphenols prevent pressure overload-induced cardiac hypertrophy and systolic dysfunction by inhibiting the extracellular signal-regulated kinase 1/2-GATA binding protein 4 pathway in cardiomyocytes.	Polyphenols	54-65	brain expressed, associated with Nedd4, 1	Mus musculus	49-53
32645737-11	2020	Thus, cacao bean polyphenols may be useful for heart failure therapy in humans.	Polyphenols	17-28	brain expressed associated with NEDD4 1	Homo sapiens	12-16
33086545-4	2020	The contents of carotenoid, soluble protein, soluble sugar, vitamin C, total flavonoids, total polyphenol and contents of total glucosinolates and organic Se were dramatically improved through the combination of Se and LED light quality.	Polyphenols	95-105	small integral membrane protein 10 like 2A	Homo sapiens	219-222
32737663-10	2020	Reduced glutathione and catalase in the liver tissue was also increased linearly (L: P < 0.05) by PPI supplementation, suggesting that natural polyphenols present in the PPI can stimulate antioxidant defence system.	Polyphenols	143-154	catalase	Gallus gallus	24-32
33084700-0	2020	Nelumbo nucifera leaf polyphenol extract and gallic acid inhibit TNF-alpha-induced vascular smooth muscle cell proliferation and migration involving the regulation of miR-21, miR-143 and miR-145.	Polyphenols	22-32	tumor necrosis factor	Rattus norvegicus	65-74
33128532-2	2022	Although modern studies revealed that MPL contains various polyphenols, terpenoids, and bis[bibenzyls], its biological effects on liver function have never been systemically studied in any animal model.	Polyphenols	59-70	MPL proto-oncogene, thrombopoietin receptor	Rattus norvegicus	38-41
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	Polyphenols	11-22	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	137-142
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	Polyphenols	11-22	heat shock protein family A (Hsp70) member 5	Homo sapiens	176-181
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	Polyphenols	11-22	heat shock protein family A (Hsp70) member 5	Homo sapiens	209-214
33081212-8	2020	Each human has different gut/oral microbiomes, so they may have different levels of polyphenol-metabolizing bacteria.	Polyphenols	84-94	glucuronidase, beta	Mus musculus	25-28
32563119-2	2020	AhR is also modulated by various endogenous ligands e.g. highly potent tryptophan (Trp)-derivative FICZ (6-formylindolo[3,2-b]carbazole) and natural ligands abundant in the human diet e.g. polyphenols.	Polyphenols	189-200	aryl hydrocarbon receptor	Homo sapiens	0-3
33074454-7	2022	Folate, vitamin B6, vitamin B12, and S-adenosylmethionine (SAM) are vital cofactors involved in DNA methylation modification; 5-azacytidine (AZA) is the most widely studied DNA methyltransferase (DNMT) inhibitor, and dietary polyphenols are DNMT inhibitors in vitro.	Polyphenols	225-236	DNA methyltransferase 1	Homo sapiens	173-194
32822152-4	2020	We explore the effectiveness of the polyphenols Epigallocatechin-3-gallate, Oleuropein aglycone, and quercetin on their ability to inhibit aggregation of amyloid-beta, tau, alpha-synuclein, and mitigate other pathological features for AD and PD.	Polyphenols	36-47	synuclein alpha	Homo sapiens	173-188
33023197-3	2020	Recently, interest in natural dietary compounds, such as polyphenols, in human health has led to a great deal of research, especially in PN.	Polyphenols	57-68	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	137-139
32768883-0	2020	Lychee seed polyphenol inhibits Abeta-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction.	Polyphenols	12-22	amyloid beta (A4) precursor protein	Mus musculus	32-37
32768883-0	2020	Lychee seed polyphenol inhibits Abeta-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction.	Polyphenols	12-22	NLR family, pyrin domain containing 3	Mus musculus	60-65
32768883-0	2020	Lychee seed polyphenol inhibits Abeta-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction.	Polyphenols	12-22	low density lipoprotein receptor-related protein 1	Mus musculus	87-91
32768883-3	2020	In addition, we have previously reported that an active lychee seed fraction enriching polyphenol (LSP) exhibits anti-neuroinflammation in Abeta-induced BV-2 cells.	Polyphenols	87-97	amyloid beta (A4) precursor protein	Mus musculus	139-144
31768871-0	2020	Antioxidant and Antiapoptotic Polyphenols from Green Tea Extract Ameliorate CCl4-Induced Acute Liver Injury in Mice.	Polyphenols	30-41	chemokine (C-C motif) ligand 4	Mus musculus	76-80
31768871-1	2020	OBJECTIVE: To investigate the phenolic composition, antioxidant properties, and hepatoprotective mechanisms of polyphenols from green tea extract (GTP) in carbon tetrachloride (CCl4)-induced acute liver injury mouse model.	Polyphenols	111-122	chemokine (C-C motif) ligand 4	Mus musculus	177-181
32750449-0	2020	Green tea polyphenols mitigate the plant lectins-induced liver inflammation and immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling pathways.	Polyphenols	10-21	NLR family, pyrin domain containing 3	Mus musculus	123-128
32750449-0	2020	Green tea polyphenols mitigate the plant lectins-induced liver inflammation and immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling pathways.	Polyphenols	10-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	133-137
32846587-2	2020	The nanoparticles with a representative polyphenol ((-)-epigallocatechin-3-gallate; EGCG) encapsulated were fabricated through an ethanol-mediated dissociation and re-assembly process of beta-CG, with greater particle size and higher surface hydrophilicity observed at higher initial EGCG concentrations.	Polyphenols	40-50	dedicator of cytokinesis 11	Homo sapiens	187-194
33178686-4	2020	These polyphenols also regulated the gene expression of cytokines such as IGF-1 and KGF, which activate the beta-catenin pathway, and TGF-beta1, which plays an important role in maintaining the niche of hair follicle stem cells, thus are thought to play roles in promoting hair growth.	Polyphenols	6-17	insulin-like growth factor 1	Mus musculus	74-79
33178686-4	2020	These polyphenols also regulated the gene expression of cytokines such as IGF-1 and KGF, which activate the beta-catenin pathway, and TGF-beta1, which plays an important role in maintaining the niche of hair follicle stem cells, thus are thought to play roles in promoting hair growth.	Polyphenols	6-17	fibroblast growth factor 7	Mus musculus	84-87
33178686-4	2020	These polyphenols also regulated the gene expression of cytokines such as IGF-1 and KGF, which activate the beta-catenin pathway, and TGF-beta1, which plays an important role in maintaining the niche of hair follicle stem cells, thus are thought to play roles in promoting hair growth.	Polyphenols	6-17	catenin (cadherin associated protein), beta 1	Mus musculus	108-120
33178686-4	2020	These polyphenols also regulated the gene expression of cytokines such as IGF-1 and KGF, which activate the beta-catenin pathway, and TGF-beta1, which plays an important role in maintaining the niche of hair follicle stem cells, thus are thought to play roles in promoting hair growth.	Polyphenols	6-17	transforming growth factor, beta 1	Mus musculus	134-143
33066504-0	2020	Effects of Polyphenols on Insulin Resistance.	Polyphenols	11-22	insulin	Homo sapiens	26-33
33066504-3	2020	Certain (poly)phenols, as supplements or in foods, can improve insulin resistance by several mechanisms including lowering postprandial glucose, modulating glucose transport, affecting insulin signalling pathways, and by protecting against damage to insulin-secreting pancreatic beta-cells.	Polyphenols	8-21	insulin	Homo sapiens	63-70
33066504-3	2020	Certain (poly)phenols, as supplements or in foods, can improve insulin resistance by several mechanisms including lowering postprandial glucose, modulating glucose transport, affecting insulin signalling pathways, and by protecting against damage to insulin-secreting pancreatic beta-cells.	Polyphenols	8-21	insulin	Homo sapiens	185-192
33066504-3	2020	Certain (poly)phenols, as supplements or in foods, can improve insulin resistance by several mechanisms including lowering postprandial glucose, modulating glucose transport, affecting insulin signalling pathways, and by protecting against damage to insulin-secreting pancreatic beta-cells.	Polyphenols	8-21	insulin	Homo sapiens	185-192
33066504-6	2020	Longer term and especially dose-response studies on mildly insulin resistant participants are required to establish the extent to which (poly)phenols and (poly)phenol-rich foods may improve insulin resistance in compromised groups.	Polyphenols	136-149	insulin	Homo sapiens	190-197
33066504-6	2020	Longer term and especially dose-response studies on mildly insulin resistant participants are required to establish the extent to which (poly)phenols and (poly)phenol-rich foods may improve insulin resistance in compromised groups.	Polyphenols	136-148	insulin	Homo sapiens	190-197
33123550-4	2020	Here we summarize the evidence demonstrating that the promotion of a healthy life style, including physical activity and a dietary intake of natural polyphenols present in coffee and tea, has the potential to improve the prevention and management of insulin resistance and diabetes in the time of COVID-19 pandemic.	Polyphenols	149-160	insulin	Homo sapiens	250-257
32563119-0	2020	In vitro differential responses of rat and human aryl hydrocarbon receptor to two distinct ligands and to different polyphenols.	Polyphenols	116-127	aryl hydrocarbon receptor	Homo sapiens	49-74
33145366-5	2020	MTA1 facilitated endometrial stroma cell proliferation, migration, and invasion by inducing EMT, and the promotion function and MTA1 expression were suppressed by resveratrol, a natural polyphenol.	Polyphenols	186-196	metastasis associated 1	Homo sapiens	0-4
32999301-0	2020	Bacillus licheniformis strain POT1 mediated polyphenol biosynthetic pathways genes activation and systemic resistance in potato plants against Alfalfa mosaic virus.	Polyphenols	44-54	protection of telomeres 1	Homo sapiens	30-34
32985606-0	2020	Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells through ROS/JNK signaling.	Polyphenols	14-24	mitogen-activated protein kinase 8	Homo sapiens	153-156
32985606-3	2020	Recently, the Annurca apple polyphenol extract (APE) has been highlighted as a multi-faceted agent that selectively kills TNBC cells by ROS generation and sustained JNK activation.	Polyphenols	28-38	mitogen-activated protein kinase 8	Homo sapiens	165-168
33145366-5	2020	MTA1 facilitated endometrial stroma cell proliferation, migration, and invasion by inducing EMT, and the promotion function and MTA1 expression were suppressed by resveratrol, a natural polyphenol.	Polyphenols	186-196	metastasis associated 1	Homo sapiens	128-132
33133574-0	2020	Antioxidant and alpha-glucosidase inhibitory capacity of nonextractable polyphenols in Mopan persimmon.	Polyphenols	72-83	sucrase-isomaltase	Homo sapiens	16-33
32969628-1	2021	BACKGROUND: Despite the abundance of studies on the beneficial effects of a fiber rich diet as well as polyphenols deriving from Citrus fruits on postprandial serum glucose and insulin, clinical evidences on their synergic effects on healthy subjects have never been published.	Polyphenols	103-114	insulin	Homo sapiens	177-184
32951435-5	2022	Polyphenols are postulated to interact with lipid rafts in two ways: first, they interfere with the structural integrity of lipid rafts, by disrupting their structure and clustering of the ordered domains; second, they modulate the downstream signaling pathways mediated by lipid rafts, by binding to receptor proteins associated with lipid rafts, such as the 67 kDa laminin receptor (67LR), epidermal growth factor receptor (EGFR), and others.	Polyphenols	0-11	ribosomal protein SA	Homo sapiens	360-383
32951435-5	2022	Polyphenols are postulated to interact with lipid rafts in two ways: first, they interfere with the structural integrity of lipid rafts, by disrupting their structure and clustering of the ordered domains; second, they modulate the downstream signaling pathways mediated by lipid rafts, by binding to receptor proteins associated with lipid rafts, such as the 67 kDa laminin receptor (67LR), epidermal growth factor receptor (EGFR), and others.	Polyphenols	0-11	ribosomal protein SA	Homo sapiens	385-389
32951435-5	2022	Polyphenols are postulated to interact with lipid rafts in two ways: first, they interfere with the structural integrity of lipid rafts, by disrupting their structure and clustering of the ordered domains; second, they modulate the downstream signaling pathways mediated by lipid rafts, by binding to receptor proteins associated with lipid rafts, such as the 67 kDa laminin receptor (67LR), epidermal growth factor receptor (EGFR), and others.	Polyphenols	0-11	epidermal growth factor receptor	Homo sapiens	392-424
32951435-5	2022	Polyphenols are postulated to interact with lipid rafts in two ways: first, they interfere with the structural integrity of lipid rafts, by disrupting their structure and clustering of the ordered domains; second, they modulate the downstream signaling pathways mediated by lipid rafts, by binding to receptor proteins associated with lipid rafts, such as the 67 kDa laminin receptor (67LR), epidermal growth factor receptor (EGFR), and others.	Polyphenols	0-11	epidermal growth factor receptor	Homo sapiens	426-430
32961777-11	2020	Meta-regressions revealed greater improvement in BDNF levels with lower percentages of female participants (Q = 40.15, df = 6, p < 0.001) and a skewed scatter plot toward a greater impact using higher (poly)phenols doses.	Polyphenols	201-214	brain derived neurotrophic factor	Homo sapiens	49-53
32957726-12	2020	In contrast, suppression of ABCG2 expression by curcumin and tea polyphenol EGCG led to greater PpIX accumulation and enhanced PDT treatment efficiency in OC cells.	Polyphenols	65-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	28-33
32933137-0	2020	Regulation of p27Kip1 and p57Kip2 Functions by Natural Polyphenols.	Polyphenols	55-66	cyclin dependent kinase inhibitor 1B	Homo sapiens	14-21
32933137-0	2020	Regulation of p27Kip1 and p57Kip2 Functions by Natural Polyphenols.	Polyphenols	55-66	cyclin dependent kinase inhibitor 1C	Homo sapiens	26-33
32933137-8	2020	The importance of p27Kip1 and p57Kip2 in polyphenols" cellular effects will be discussed with the aim of identifying novel therapeutic strategies for the treatment of important human diseases, such as cancers, characterized by an altered control of growth.	Polyphenols	41-52	cyclin dependent kinase inhibitor 1B	Homo sapiens	18-25
32933137-8	2020	The importance of p27Kip1 and p57Kip2 in polyphenols" cellular effects will be discussed with the aim of identifying novel therapeutic strategies for the treatment of important human diseases, such as cancers, characterized by an altered control of growth.	Polyphenols	41-52	cyclin dependent kinase inhibitor 1C	Homo sapiens	30-37
32344342-2	2020	In this study, 1H NMR validated polyphenols and polysaccharides extracted from sprouted quinoa yoghurt were used as isolates and conjugates to upregulate the stimulation of GLP-1 release in NCI-H716 cells.	Polyphenols	32-43	glucagon like peptide 1 receptor	Homo sapiens	173-178
33133574-1	2020	This study was to evaluate and compare the polyphenols contents, antioxidant capacities, and alpha-glucosidase inhibitory abilities of extractable and nonextractable polyphenols (EP and NEP) in Mopan persimmon.	Polyphenols	166-177	sucrase-isomaltase	Homo sapiens	93-110
32933011-3	2020	Polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) and pigment epithelium-derived factor (PEDF) bind to 67LR and inhibit neovascularization.	Polyphenols	0-10	serpin family F member 1	Rattus norvegicus	90-94
32901517-4	2022	To achieve the objectives, this review summarizes the results of the researches realized in recent years in clinical trials and in various experimental models, on the effects of foods rich in polyphenols, polyphenolic extracts, and commercially polyphenols on insulin resistance and beta-cells death.	Polyphenols	245-256	insulin	Homo sapiens	260-267
32901517-0	2022	Plant polyphenols mechanisms of action on insulin resistance and against the loss of pancreatic beta cells.	Polyphenols	6-17	insulin	Homo sapiens	42-49
32901517-3	2022	This review article is focused on synthesizing the mechanisms by which polyphenols decrease insulin resistance and inhibit loss of pancreatic islet beta-cell mass and function.	Polyphenols	71-82	insulin	Homo sapiens	92-99
32867057-0	2020	Polyphenols by Generating H2O2, Affect Cell Redox Signaling, Inhibit PTPs and Activate Nrf2 Axis for Adaptation and Cell Surviving: In Vitro, In Vivo and Human Health.	Polyphenols	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
32895481-7	2020	The myocardial protective effect of grape polyphenol might likely be due to the increase in the level and activity of the antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase.	Polyphenols	42-52	catalase	Rattus norvegicus	165-173
32394290-2	2020	METHODS: This study used an ethanol extract of propolis at a concentration of 300 mg mL-1, with a total polyphenol concentration of 2.77 mg mL-1 as determined by chromatography.	Polyphenols	104-114	L1 cell adhesion molecule	Mus musculus	140-144
32768953-5	2020	Both polyphenols acted as potent vasodilators and this effect was associated with increased phosphorylation of Akt and endothelial NO synthase (eNOS).	Polyphenols	5-16	thymoma viral proto-oncogene 1	Mus musculus	111-114
32768953-5	2020	Both polyphenols acted as potent vasodilators and this effect was associated with increased phosphorylation of Akt and endothelial NO synthase (eNOS).	Polyphenols	5-16	nitric oxide synthase 3, endothelial cell	Mus musculus	119-142
32768953-5	2020	Both polyphenols acted as potent vasodilators and this effect was associated with increased phosphorylation of Akt and endothelial NO synthase (eNOS).	Polyphenols	5-16	nitric oxide synthase 3, endothelial cell	Mus musculus	144-148
32768953-8	2020	These results suggested that plant polyphenols MO and QU both promote eNOS-mediated NO production and vasodilation in diabetic aorta, MO via Akt pathway activation and QU via PI3K/Akt and AMPK pathway activation.	Polyphenols	35-46	nitric oxide synthase 3, endothelial cell	Mus musculus	70-74
32768953-8	2020	These results suggested that plant polyphenols MO and QU both promote eNOS-mediated NO production and vasodilation in diabetic aorta, MO via Akt pathway activation and QU via PI3K/Akt and AMPK pathway activation.	Polyphenols	35-46	thymoma viral proto-oncogene 1	Mus musculus	141-144
32768953-8	2020	These results suggested that plant polyphenols MO and QU both promote eNOS-mediated NO production and vasodilation in diabetic aorta, MO via Akt pathway activation and QU via PI3K/Akt and AMPK pathway activation.	Polyphenols	35-46	thymoma viral proto-oncogene 1	Mus musculus	180-183
33164378-0	2020	[Study on binding kinetics profiles of tea polyphenols-alpha-glucosidase interaction].	Polyphenols	43-54	sucrase-isomaltase	Homo sapiens	55-72
33164378-2	2020	Herein, using ECG as research object, the surface plasmon resonance(SPR) analysis were employed to study the binding affinities and kinetic parameters of three tea polyphenols components on alpha-glucosidase, respectively.	Polyphenols	164-175	sucrase-isomaltase	Homo sapiens	190-207
33164378-3	2020	The concentration-time curve mathematical model of the drug in the unstirred water layer(the adjacent region of alpha-glucosidase) established previously by our group was used to evaluate the concentration-time curves of the tea polyphenols in the alpha-glucosidase vicinity.	Polyphenols	229-240	sucrase-isomaltase	Homo sapiens	112-129
33164378-3	2020	The concentration-time curve mathematical model of the drug in the unstirred water layer(the adjacent region of alpha-glucosidase) established previously by our group was used to evaluate the concentration-time curves of the tea polyphenols in the alpha-glucosidase vicinity.	Polyphenols	229-240	sucrase-isomaltase	Homo sapiens	248-265
32867057-7	2020	Pre-treatment of cells or organisms with polyphenols, by generating H2O2 at low levels, inhibits cellular PTPs (protein tyrosine phosphatases), inducing cell signaling through transcription of the Nrf2 (nuclear factor erythroid 2-related factor 2) axis of adaptation and protection to oxidation stress.	Polyphenols	41-52	NFE2 like bZIP transcription factor 2	Homo sapiens	197-201
32867057-7	2020	Pre-treatment of cells or organisms with polyphenols, by generating H2O2 at low levels, inhibits cellular PTPs (protein tyrosine phosphatases), inducing cell signaling through transcription of the Nrf2 (nuclear factor erythroid 2-related factor 2) axis of adaptation and protection to oxidation stress.	Polyphenols	41-52	NFE2 like bZIP transcription factor 2	Homo sapiens	203-246
32786866-0	2020	Dietary Polyphenols Inhibit the Cytochrome P450 Monooxygenase Branch of the Arachidonic Acid Cascade with Remarkable Structure-Dependent Selectivity and Potency.	Polyphenols	8-19	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	32-61
32786866-2	2020	In a liver microsome-based multienzyme assay using AA as natural substrate, we investigated how polyphenols inhibit different oxylipin-forming CYP in parallel but independently from each other.	Polyphenols	96-107	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	143-146
32786866-4	2020	The oxylipin formation was inhibited by several polyphenols with a remarkable selectivity and a potency comparable to known CYP inhibitors.	Polyphenols	48-59	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	124-127
32662804-6	2020	One promising polyphenol compound that has found application in this area is curcumin due to its natural binding affinity to Abeta fibrils and oligomers while giving out a strong fluorescence signal.	Polyphenols	14-24	amyloid beta (A4) precursor protein	Mus musculus	125-130
32135183-0	2020	Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy.	Polyphenols	45-56	AKT serine/threonine kinase 1	Homo sapiens	15-18
32922655-8	2020	Furthermore, pathological observation showed that the Shoumei polyphenols reduced CCl4-induced hepatocyte damage.	Polyphenols	62-73	C-C motif chemokine ligand 4	Homo sapiens	82-86
32922655-10	2020	The Shoumei polyphenols had a preventive effect against CCl4-induced mouse liver injury equivalent to that of silymarin.	Polyphenols	12-23	C-C motif chemokine ligand 4	Homo sapiens	56-60
32135183-0	2020	Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy.	Polyphenols	45-56	mechanistic target of rapamycin kinase	Homo sapiens	19-23
32135183-6	2020	One of the cellular pathways commonly affected by polyphenols is PI3K/Akt/mTOR pathway, which has far ranging effects on multiple key aspects of cellular growth, metabolism and death.	Polyphenols	50-61	AKT serine/threonine kinase 1	Homo sapiens	70-73
32903408-7	2020	In fact, several polyphenols, catechins, quinones, and peptides obtained from natural sources (including nuts, oils, root extracts, and fungi metabolites) have been described as promising KATi.	Polyphenols	17-28	kynurenine aminotransferase 1	Homo sapiens	188-192
32135183-6	2020	One of the cellular pathways commonly affected by polyphenols is PI3K/Akt/mTOR pathway, which has far ranging effects on multiple key aspects of cellular growth, metabolism and death.	Polyphenols	50-61	mechanistic target of rapamycin kinase	Homo sapiens	74-78
32135183-7	2020	In this review article, evidence regarding the biology of polyphenols in cancer via PI3K/Akt/mTOR pathway is discussed and their application on cancer pathophysiology in various types of human malignancies is shown.	Polyphenols	58-69	AKT serine/threonine kinase 1	Homo sapiens	89-92
32135183-7	2020	In this review article, evidence regarding the biology of polyphenols in cancer via PI3K/Akt/mTOR pathway is discussed and their application on cancer pathophysiology in various types of human malignancies is shown.	Polyphenols	58-69	mechanistic target of rapamycin kinase	Homo sapiens	93-97
32823596-4	2020	In the study, selective cytotoxicity, pro-apoptotic, autophagic and Anx-A1 downregulating properties of PU were shown which indicate therapeutic potential that this polyphenol has against CRC.	Polyphenols	165-175	annexin A1	Homo sapiens	68-74
32762411-6	2021	It was already reported that Broussonetia papyrifera polyphenols efficiently inhibit the catalytic activity of SARS CoV-1 and MERS Mpro.	Polyphenols	53-64	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	131-135
32453025-0	2020	Tea polyphenols protect learning and memory in sleep-deprived mice by promoting AMPA receptor internalization.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
32453025-6	2020	Tea polyphenols, major active compounds in green tea, suppressed TNFalpha production through downregulating TNFalpha converting enzyme (TACE) level.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
32453025-6	2020	Tea polyphenols, major active compounds in green tea, suppressed TNFalpha production through downregulating TNFalpha converting enzyme (TACE) level.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	49-52
32453025-6	2020	Tea polyphenols, major active compounds in green tea, suppressed TNFalpha production through downregulating TNFalpha converting enzyme (TACE) level.	Polyphenols	4-15	tumor necrosis factor	Mus musculus	65-73
32453025-6	2020	Tea polyphenols, major active compounds in green tea, suppressed TNFalpha production through downregulating TNFalpha converting enzyme (TACE) level.	Polyphenols	4-15	a disintegrin and metallopeptidase domain 17	Mus musculus	108-134
32453025-6	2020	Tea polyphenols, major active compounds in green tea, suppressed TNFalpha production through downregulating TNFalpha converting enzyme (TACE) level.	Polyphenols	4-15	a disintegrin and metallopeptidase domain 17	Mus musculus	136-140
32453025-7	2020	Meanwhile, tea polyphenols treatment could ameliorate recognition impairment and anxiety-like behaviors in S-DEP mice.	Polyphenols	15-26	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	11-14
32453025-8	2020	The aforementioned results demonstrate cognition protective effects of tea polyphenols in S-DEP mice model, which provide a theoretical basis for the treatments of S-DEP-induced cognition impairment by targeting the TACE/TNFalpha/AMPA pathway.	Polyphenols	75-86	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	71-74
32453025-8	2020	The aforementioned results demonstrate cognition protective effects of tea polyphenols in S-DEP mice model, which provide a theoretical basis for the treatments of S-DEP-induced cognition impairment by targeting the TACE/TNFalpha/AMPA pathway.	Polyphenols	75-86	a disintegrin and metallopeptidase domain 17	Mus musculus	216-220
32453025-8	2020	The aforementioned results demonstrate cognition protective effects of tea polyphenols in S-DEP mice model, which provide a theoretical basis for the treatments of S-DEP-induced cognition impairment by targeting the TACE/TNFalpha/AMPA pathway.	Polyphenols	75-86	tumor necrosis factor	Mus musculus	221-229
32762411-7	2021	But whether these polyphenols exhibit any inhibitory effect on SARS CoV-2 Mpro is far from clear.	Polyphenols	18-29	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	74-78
32762411-9	2021	Polyphenols having proper drug-likeness properties and two repurposed drugs (lopinavir and darunavir; having binding affinity -7.3 to -7.4 kcal/mol) were docked against SARS CoV-2 Mpro to study their binding properties.	Polyphenols	0-11	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	180-184
32762411-11	2021	Molecular dynamic simulations (100 ns) revealed that all Mpro-polyphenol complexes are more stable, conformationally less fluctuated; slightly less compact and marginally expanded than Mpro-darunavir/lopinavir complex.	Polyphenols	62-72	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	57-61
32762411-11	2021	Molecular dynamic simulations (100 ns) revealed that all Mpro-polyphenol complexes are more stable, conformationally less fluctuated; slightly less compact and marginally expanded than Mpro-darunavir/lopinavir complex.	Polyphenols	62-72	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	185-189
32762411-12	2021	Even the number of intermolecular H-bond and MM-GBSA analysis suggested that these six polyphenols are more potent Mpro inhibitors than the two repurposed drugs (lopinavir and darunavir) and may serve as promising anti-COVID-19 drugs.	Polyphenols	87-98	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	115-119
32714738-7	2020	Further, the total polyphenol content was significantly reduced, which helps to enhance the protein enrichment and small-molecule inhibitor screening by ABPP.	Polyphenols	19-29	amyloid beta precursor protein	Homo sapiens	153-157
32771984-0	2020	Polyphenol-induced improvements in glucose metabolism are associated with bile acid signaling to intestinal farnesoid X receptor.	Polyphenols	0-10	glucosidase beta 2	Mus musculus	74-83
32771984-0	2020	Polyphenol-induced improvements in glucose metabolism are associated with bile acid signaling to intestinal farnesoid X receptor.	Polyphenols	0-10	nuclear receptor subfamily 1, group H, member 4	Mus musculus	108-128
32771984-2	2020	Altered BA-FXR signaling was therefore investigated as a potential mechanism linking polyphenol-induced gut bacterial changes and improved glucose metabolism.	Polyphenols	85-95	nuclear receptor subfamily 1, group H, member 4	Mus musculus	11-14
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Polyphenols	138-148	albumin	Homo sapiens	50-85
32562310-6	2020	CONCLUSIONS: During the postprandial state, the levels of let-7e-5p decreased with EVOO regardless of polyphenol content suggesting a general response to the fatty acid composition of EVOO or/and the presence of at least 250 mg polyphenol/kg olive oil.	Polyphenols	228-238	microRNA let-7e	Homo sapiens	58-64
32929381-0	2020	Oral delivery of anti-TNF antibody shielded by natural polyphenol-mediated supramolecular assembly for inflammatory bowel disease therapy.	Polyphenols	55-65	tumor necrosis factor	Mus musculus	22-25
32275992-2	2020	Our previous study and other studies suggested that the gallate moiety played an obligatory role in the inhibition process of naturally occurring polyphenols on Abeta amyloid fibrils formation.	Polyphenols	146-157	amyloid beta precursor protein	Homo sapiens	161-166
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Polyphenols	138-148	hydroxyacid oxidase 1	Homo sapiens	87-90
32731516-5	2020	Dietary polyphenols can influence milk FA profile, reducing or inhibiting the activity and growth of some strains of rumen microbes involved in the biohydrogenation of PUFA.	Polyphenols	8-19	PUFA	Ovis aries	168-172
32802126-4	2020	This study aims to determine if date seed polyphenols inhibit the activity of the enzymes (alpha-amylase and alpha-glucosidase), responsible for the digestion of carbohydrates and modulating the glucose uptake by human liver cells.	Polyphenols	42-53	sucrase-isomaltase	Homo sapiens	109-126
32720577-0	2021	Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis.	Polyphenols	22-33	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	116-120
32720577-5	2021	Interestingly, several plant-derived polyphenols effectively inhibit the RdRp of other RNA viruses.	Polyphenols	37-48	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	73-77
32686994-0	2021	In silico analysis of polyphenols and flavonoids for design of human Nav1.7 inhibitors.	Polyphenols	22-33	sodium voltage-gated channel alpha subunit 9	Homo sapiens	69-75
32720577-7	2021	We were curious to study the binding of polyphenols with SARS-CoV-2 RdRp and assess their potential to treat COVID-19.	Polyphenols	40-51	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	68-72
32679729-3	2020	Pharmacological reagents, including statins, metformin, berberine, polyphenol, and resveratrol, all of which are widely used therapeutics for cardiovascular disorders, appear to deliver their protective/therapeutic effects partially via AMPK signaling modulation.	Polyphenols	67-77	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	237-241
32678222-0	2020	The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase alpha.	Polyphenols	53-63	diacylglycerol kinase alpha	Homo sapiens	97-124
32672134-0	2021	Polyphenol-Enriched Extracts from Trapa acornis Husks Inhibit Her2-Positive SK-BR-3 Breast Cancer Cell Proliferation and In Vivo Tumor Angiogenesis.	Polyphenols	0-10	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-66
32334376-0	2020	White tea and its active polyphenols lower cholesterol through reduction of very-low-density lipoprotein production and induction of LDLR expression.	Polyphenols	25-36	low density lipoprotein receptor	Homo sapiens	133-137
32674299-5	2020	The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1.	Polyphenols	42-53	BCL2 apoptosis regulator	Homo sapiens	92-97
32674299-5	2020	The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1.	Polyphenols	42-53	uncoupling protein 2	Homo sapiens	99-103
32674299-5	2020	The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1.	Polyphenols	42-53	sirtuin 1	Homo sapiens	105-111
32674299-5	2020	The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1.	Polyphenols	42-53	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	113-117
32674299-5	2020	The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1.	Polyphenols	42-53	mitogen-activated protein kinase 8	Homo sapiens	122-126
32641048-0	2020	Tea polyphenols attenuate liver inflammation by modulating obesity-related genes and down-regulating COX-2 and iNOS expression in high fat-fed dogs.	Polyphenols	4-15	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	101-106
32641048-0	2020	Tea polyphenols attenuate liver inflammation by modulating obesity-related genes and down-regulating COX-2 and iNOS expression in high fat-fed dogs.	Polyphenols	4-15	nitric oxide synthase 2	Canis lupus familiaris	111-115
32630636-3	2020	This study evaluated the protective effects of characterized polyphenol-rich medicinal plant extracts on redox, inflammatory and vasoactive markers on murine bEnd3 cerebral endothelial cells exposed to high glucose concentration.	Polyphenols	61-71	BEN domain containing 3	Mus musculus	158-163
32495621-5	2020	A blood model with flavanones determined the % of polyphenol that was inside RBC and bound to the surface using a new albumin washing procedure.	Polyphenols	50-60	albumin	Homo sapiens	118-125
32422565-0	2020	Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism.	Polyphenols	18-29	adiponectin receptor 1	Homo sapiens	77-99
32495621-8	2020	More polyphenols were found with albumin and lipoproteins (HDL and LDL) than with RBC.	Polyphenols	5-16	albumin	Homo sapiens	33-40
32495621-9	2020	In the plasma model the polyphenols associated almost equally between lipoproteins and albumin.	Polyphenols	24-35	albumin	Homo sapiens	87-94
32506808-9	2020	Curcumin and other dietary polyphenols are bone protective and block RANKL-stimulated osteoclastogenesis.	Polyphenols	27-38	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	69-74
32447828-6	2020	In vitro, polyphenols improved ROS levels, Cu/ZnSOD activity and both Nox4 and Nrf2 gene expression deregulated by high glucose.	Polyphenols	10-21	superoxide dismutase 1, soluble	Mus musculus	43-51
32447828-6	2020	In vitro, polyphenols improved ROS levels, Cu/ZnSOD activity and both Nox4 and Nrf2 gene expression deregulated by high glucose.	Polyphenols	10-21	NADPH oxidase 4	Mus musculus	70-74
32447828-6	2020	In vitro, polyphenols improved ROS levels, Cu/ZnSOD activity and both Nox4 and Nrf2 gene expression deregulated by high glucose.	Polyphenols	10-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
32447828-7	2020	Polyphenols reduced Nrf2 nuclear translocation, and counteracted NFkB pathway activation, IL-6 secretion and the altered production of vasoactive markers mediated by high glucose.	Polyphenols	0-11	nuclear factor, erythroid derived 2, like 2	Mus musculus	20-24
32801469-0	2020	Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion.	Polyphenols	6-17	glucagon	Homo sapiens	75-98
32490857-6	2020	The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function.	Polyphenols	4-15	interleukin 6	Homo sapiens	160-164
30289026-8	2020	These data provide a clear time course of the reversible inhibition of MAO-B after the single consumption of a of New Zealand "Blackadder" blackcurrant juice standardised at 500 mg of polyphenols and, therefore, provide a therapeutic window on which to base future nutritional interventions.	Polyphenols	184-195	monoamine oxidase B	Homo sapiens	71-76
32655263-6	2020	We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factor kappaB (NF-kappaB) and JAK/STAT signaling pathways.	Polyphenols	14-25	nitric oxide synthase 2	Homo sapiens	103-107
32655263-6	2020	We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factor kappaB (NF-kappaB) and JAK/STAT signaling pathways.	Polyphenols	14-25	nuclear factor kappa B subunit 1	Homo sapiens	154-163
32490857-6	2020	The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function.	Polyphenols	4-15	tumor necrosis factor	Homo sapiens	149-158
32447828-7	2020	Polyphenols reduced Nrf2 nuclear translocation, and counteracted NFkB pathway activation, IL-6 secretion and the altered production of vasoactive markers mediated by high glucose.	Polyphenols	0-11	interleukin 6	Mus musculus	90-94
32447828-9	2020	Polyphenols attenuated redox changes, increased VE-Cadherin production and decreased neuro-inflammation in infarcted hemisphere.	Polyphenols	0-11	cadherin 5	Mus musculus	48-59
32490857-6	2020	The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function.	Polyphenols	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
32490857-6	2020	The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function.	Polyphenols	4-15	interleukin 1 alpha	Homo sapiens	176-184
32490857-6	2020	The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function.	Polyphenols	4-15	nuclear factor kappa B subunit 1	Homo sapiens	202-211
32490857-6	2020	The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function.	Polyphenols	4-15	NFE2 like bZIP transcription factor 2	Homo sapiens	229-233
32568613-0	2021	Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors - an in silico docking and molecular dynamics simulation study.	Polyphenols	24-35	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	86-90
32568613-5	2021	In order to find potent Mpro inhibitors, we have selected eight polyphenols from green tea, as these are already known to exert antiviral activity against many RNA viruses.	Polyphenols	64-75	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	24-28
32568613-6	2021	We have elucidated the binding affinities and binding modes between these polyphenols including a well-known Mpro inhibitor N3 (having binding affinity -7.0 kcal/mol) and Mpro using molecular docking studies.	Polyphenols	74-85	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	109-113
32568613-6	2021	We have elucidated the binding affinities and binding modes between these polyphenols including a well-known Mpro inhibitor N3 (having binding affinity -7.0 kcal/mol) and Mpro using molecular docking studies.	Polyphenols	74-85	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	171-175
32568613-7	2021	All eight polyphenols exhibit good binding affinity toward Mpro (-7.1 to -9.0 kcal/mol).	Polyphenols	10-21	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	59-63
32568613-8	2021	However, only three polyphenols (epigallocatechin gallate, epicatechingallate and gallocatechin-3-gallate) interact strongly with one or both catalytic residues (His41 and Cys145) of Mpro.	Polyphenols	20-31	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	183-187
32568613-9	2021	Molecular dynamics simulations (100 ns) on these three Mpro-polyphenol systems further reveal that these complexes are highly stable, experience less conformational fluctuations and share similar degree of compactness.	Polyphenols	60-70	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	55-59
32568613-10	2021	Estimation of total number of intermolecular H-bond and MM-GBSA analysis affirm the stability of these three Mpro-polyphenol complexes.	Polyphenols	114-124	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	109-113
32568613-12	2021	Altogether, our study shows that these three polyphenols can be used as potential inhibitors against SARS CoV-2 Mpro and are promising drug candidates for COVID-19 treatment.Communicated by Ramaswamy H. Sarma.	Polyphenols	45-56	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	112-116
32311492-5	2020	Stilbenoids are bioactive polyphenols and earlier studies have shown that imine stilbene exert cardioprotective and anti aging effects by acting as modulators of Sirt1.	Polyphenols	26-37	sirtuin 1	Rattus norvegicus	162-167
32630488-9	2020	As NOND is apoptotic, we speculate that PPs act by inhibiting executioner caspase 3.	Polyphenols	40-43	caspase 3	Mus musculus	74-83
32432582-0	2020	Coupling PEG-LZM polymer networks with polyphenols yields suturable biohydrogels for tissue patching.	Polyphenols	39-50	lysozyme	Homo sapiens	13-16
32432582-3	2020	Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM.	Polyphenols	8-19	lysozyme	Homo sapiens	88-100
32432582-3	2020	Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM.	Polyphenols	8-19	lysozyme	Homo sapiens	102-105
32432582-3	2020	Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM.	Polyphenols	8-19	lysozyme	Homo sapiens	300-303
32432582-3	2020	Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM.	Polyphenols	124-135	lysozyme	Homo sapiens	88-100
32432582-3	2020	Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM.	Polyphenols	124-135	lysozyme	Homo sapiens	102-105
32432582-3	2020	Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM.	Polyphenols	124-135	lysozyme	Homo sapiens	300-303
32432582-4	2020	By utilizing polyphenols as noncovalent crosslinkers, the resultant PEG-LZM-polyphenol hydrogel presents super toughness and high elasticity in comparison to pristine PEG-LZM with no obvious changes in the initial shape, and it can even withstand the high pressure from sutures.	Polyphenols	13-24	lysozyme	Homo sapiens	72-75
32432582-4	2020	By utilizing polyphenols as noncovalent crosslinkers, the resultant PEG-LZM-polyphenol hydrogel presents super toughness and high elasticity in comparison to pristine PEG-LZM with no obvious changes in the initial shape, and it can even withstand the high pressure from sutures.	Polyphenols	13-24	lysozyme	Homo sapiens	171-174
32432582-4	2020	By utilizing polyphenols as noncovalent crosslinkers, the resultant PEG-LZM-polyphenol hydrogel presents super toughness and high elasticity in comparison to pristine PEG-LZM with no obvious changes in the initial shape, and it can even withstand the high pressure from sutures.	Polyphenols	13-23	lysozyme	Homo sapiens	72-75
32432582-6	2020	Interestingly, the PEG-LZM-polyphenol hydrogel has a higher water content than other polyphenol-toughened hydrogels, which may better meet the clinical needs for hydrogel materials.	Polyphenols	27-37	lysozyme	Homo sapiens	23-26
32432582-6	2020	Interestingly, the PEG-LZM-polyphenol hydrogel has a higher water content than other polyphenol-toughened hydrogels, which may better meet the clinical needs for hydrogel materials.	Polyphenols	85-95	lysozyme	Homo sapiens	23-26
32837872-6	2020	Notably, some natural products with different chemotypes including protoberberine alkaloids, flavones, polyphenols, and cyclic peptides have shown effectiveness against LSD1.	Polyphenols	103-114	lysine demethylase 1A	Homo sapiens	169-173
32505192-0	2020	Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-delta-dependent ROS signal.	Polyphenols	21-31	matrix metallopeptidase 9	Rattus norvegicus	67-93
32221603-7	2020	When other inflammation biomarkers were considered, the serum IL-10 concentration was inversely associated with total polyphenol (beta = -0.12, P = 0.017) and flavonoid (beta = -0.12, P = 0.013) intakes, findings that were inconsistent with the biomarker ratio results.	Polyphenols	118-128	interleukin 10	Homo sapiens	62-67
32221603-8	2020	However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (beta = 0.09 P = 0.049) and stilbene (beta = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-gamma with lignan intake (beta = -0.10, P = 0.034; beta = -0.09, P = 0.049; beta = -0.11, P = 0.023).	Polyphenols	43-54	interleukin 1 alpha	Homo sapiens	223-227
32221603-8	2020	However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (beta = 0.09 P = 0.049) and stilbene (beta = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-gamma with lignan intake (beta = -0.10, P = 0.034; beta = -0.09, P = 0.049; beta = -0.11, P = 0.023).	Polyphenols	43-54	interleukin 4	Homo sapiens	97-101
32221603-8	2020	However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (beta = 0.09 P = 0.049) and stilbene (beta = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-gamma with lignan intake (beta = -0.10, P = 0.034; beta = -0.09, P = 0.049; beta = -0.11, P = 0.023).	Polyphenols	43-54	interleukin 2	Homo sapiens	229-233
32221603-8	2020	However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (beta = 0.09 P = 0.049) and stilbene (beta = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-gamma with lignan intake (beta = -0.10, P = 0.034; beta = -0.09, P = 0.049; beta = -0.11, P = 0.023).	Polyphenols	43-54	interferon gamma	Homo sapiens	239-248
32018136-2	2020	The conjugation between SPI and cyanidin-3-galactoside was confirmed by the increased ratio of bound polyphenol and the disappearance of cyanidin-3-galactoside"s absorption peak in ultraviolet-visible spectrum.	Polyphenols	101-111	chromogranin A	Homo sapiens	24-27
32334345-7	2020	Treatment with polyphenols prevented the depressive- and anxiety-like behaviours induced by MS, where xanthohumol effects were correlated with rescue of BDNF plasma levels.	Polyphenols	15-26	brain-derived neurotrophic factor	Rattus norvegicus	153-157
32334345-13	2020	These results suggest that naturally-derived polyphenols exert antidepressant-like effects in MS rats, which mechanisms could be potentially mediated by HPA regulation, BDNF levels rescue and modulation of the microbiota-gut-brain axis.	Polyphenols	45-56	brain-derived neurotrophic factor	Rattus norvegicus	169-173
32007220-9	2020	In blank Flos Lonicerae Beverage, 11 kinds of polyphenols ranged from 0.54 ng mL-1 to 52.99 ng mL-1 were detected.	Polyphenols	46-57	L1 cell adhesion molecule	Mus musculus	78-82
32466148-10	2020	The meta-analysis indicated that (poly)phenol supplementation significantly increased brain-derived neurotrophic factor (ES = 3.259, p = 0.033), which was accompanied by higher performance in serial (7s) subtraction (ES = 1.467, p = 0.001) and decreases in simple reaction time (ES = -0.926, p = 0.015) and mental fatigue (ES = -3.521 p = 0.010).	Polyphenols	33-45	brain derived neurotrophic factor	Homo sapiens	86-119
32666033-2	2020	A systematic review and meta-analysis was therefore conducted to evaluate the effect of berry polyphenol consumption on glucose metabolism in adults with impaired glucose tolerance or insulin resistance.	Polyphenols	94-104	insulin	Homo sapiens	184-191
32007220-9	2020	In blank Flos Lonicerae Beverage, 11 kinds of polyphenols ranged from 0.54 ng mL-1 to 52.99 ng mL-1 were detected.	Polyphenols	46-57	L1 cell adhesion molecule	Mus musculus	95-99
32173528-4	2020	Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) directly binds to cell-surface 67LR and induces apoptosis through the protein kinase B (Akt)/endothelial nitric oxide synthase/nitric oxide/cyclic GMP (cGMP) axis.	Polyphenols	10-20	protein tyrosine kinase 2 beta	Homo sapiens	131-147
31972341-7	2020	Measurements after 24 h of mRNA for mitochondria-related proteins and of SIRT1 enzyme activity suggested an involvement of increased mitochondrial biogenesis in the polyphenol effects.	Polyphenols	165-175	sirtuin 1	Mus musculus	73-78
32423164-7	2020	Increased concentration of individual polyphenols was directly associated with improved ability of sprouts for radical scavenging and reduction of tumor necrosis factor alpha and interleukin 6 in macrophages.	Polyphenols	38-49	tumor necrosis factor	Homo sapiens	147-174
32423164-7	2020	Increased concentration of individual polyphenols was directly associated with improved ability of sprouts for radical scavenging and reduction of tumor necrosis factor alpha and interleukin 6 in macrophages.	Polyphenols	38-49	interleukin 6	Homo sapiens	179-192
32173528-4	2020	Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) directly binds to cell-surface 67LR and induces apoptosis through the protein kinase B (Akt)/endothelial nitric oxide synthase/nitric oxide/cyclic GMP (cGMP) axis.	Polyphenols	10-20	AKT serine/threonine kinase 1	Homo sapiens	149-152
32173528-4	2020	Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) directly binds to cell-surface 67LR and induces apoptosis through the protein kinase B (Akt)/endothelial nitric oxide synthase/nitric oxide/cyclic GMP (cGMP) axis.	Polyphenols	10-20	nitric oxide synthase 3	Homo sapiens	154-187
32070787-5	2020	Another major aspect of the hypothesis is that phenol or polyphenol molecules, found in various plants, may combine with particular fats or even ethanol to form dopamine, which can then be converted to norepinephrine through the already established step involving the enzyme dopamine beta-hydroxylase.	Polyphenols	57-67	dopamine beta-hydroxylase	Homo sapiens	275-300
32279625-4	2020	Within these ranges of applications, other compounds, such as plant polyphenols, may favourably add synergic effects through the modulation of carbohydrate digestion and glucose metabolic steps, resulting in lowering postprandial glucose and insulin levels.	Polyphenols	68-79	insulin	Homo sapiens	242-249
32303322-3	2020	In human studies, diets containing a polyphenol (resveratrol) led to improvements in insulin sensitivity.	Polyphenols	37-47	insulin	Homo sapiens	85-92
32303322-5	2020	We hypothesize a supplementation with a low dose of a synergistic polyphenol and amino acid blend including leucine (SPB+L) would improve metabolic health in EMS/insulin dysregulated horses.	Polyphenols	66-76	INS	Equus caballus	162-169
31972553-2	2020	Polyphenols, including curcumin, procyanidin and quercetin etc., have showed great calcification inhibition potential in crosslinking collagen and elastin scaffolds.	Polyphenols	0-11	elastin	Bos taurus	147-154
32269896-11	2020	Our study suggested that polyphenols in CSEaq might be responsible for protecting WRL-68 cells from Cr(VI)-governed oxidative assault that would have otherwise led to survivin/mTOR-mediated autophagic death.	Polyphenols	25-36	mechanistic target of rapamycin kinase	Homo sapiens	176-180
32346497-0	2020	Functional analysis of down-regulated miRNA-221-5p in HeLa cell treated with polyphenol-rich Polyalthia longifolia as regulators of apoptotic HeLa cell death.	Polyphenols	77-87	microRNA 221	Homo sapiens	38-47
32346497-7	2020	The MTT assay results revealed that the over-expression of miR-221-5p increased the cell proliferation and viability of polyphenol-rich P. longifolia-treated HeLa cells and confirmed the role of downregulated miRNA 221-5p in HeLa cell death.	Polyphenols	120-130	microRNA 221	Homo sapiens	59-66
32346497-8	2020	The flow-cytometry analysis showed that the miR-221-5p over-expressed cells decreased the apoptosis of cells induced by polyphenol-rich P. longifolia treatment in HeLa cells, which proved the oncogenic role of miR-221-5p to inhibit apoptosis.	Polyphenols	120-130	microRNA 221	Homo sapiens	44-51
32346497-8	2020	The flow-cytometry analysis showed that the miR-221-5p over-expressed cells decreased the apoptosis of cells induced by polyphenol-rich P. longifolia treatment in HeLa cells, which proved the oncogenic role of miR-221-5p to inhibit apoptosis.	Polyphenols	120-130	microRNA 221	Homo sapiens	210-217
32204114-0	2020	Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway.	Polyphenols	27-37	AKT serine/threonine kinase 1	Rattus norvegicus	139-142
32227855-0	2020	Cerasus humilis Cherry Polyphenol Reduces High-Fat Diet-Induced Obesity in C57BL/6 Mice by Mitigating Fat Deposition, Inflammation, and Oxidation.	Polyphenols	23-33	CD36 molecule	Mus musculus	47-50
32340142-6	2020	These properties could be attributed to the polyphenols, mainly anthocyanins and flavonols, detected by RP-HPLC-DAD-ESI-MSn.	Polyphenols	44-55	moesin	Homo sapiens	120-123
32326231-0	2020	Polyphenols Extracted from Artemisia annua L. Exhibit Anti-Cancer Effects on Radio-Resistant MDA-MB-231 Human Breast Cancer Cells by Suppressing Stem Cell Phenotype, beta-Catenin, and MMP-9.	Polyphenols	0-11	catenin beta 1	Homo sapiens	166-178
32326231-0	2020	Polyphenols Extracted from Artemisia annua L. Exhibit Anti-Cancer Effects on Radio-Resistant MDA-MB-231 Human Breast Cancer Cells by Suppressing Stem Cell Phenotype, beta-Catenin, and MMP-9.	Polyphenols	0-11	matrix metallopeptidase 9	Homo sapiens	184-189
32387991-0	2020	Insoluble-bound polyphenols of adlay seed ameliorate H2O2-induced oxidative stress in HepG2 cells via Nrf2 signalling.	Polyphenols	16-27	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
32387991-8	2020	Thus the results demonstrated that ferulic acid, the main active component of insoluble-bound polyphenol in adlay seed could ameliorate H2O2-induced oxidative stress in HepG2 cells via Nrf2 signalling.	Polyphenols	94-104	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Polyphenols	4-15	brain-derived neurotrophic factor	Rattus norvegicus	89-93
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Polyphenols	4-15	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	94-98
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Polyphenols	4-15	AKT serine/threonine kinase 1	Rattus norvegicus	99-102
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Polyphenols	4-15	mitogen activated protein kinase 3	Rattus norvegicus	107-113
32227855-0	2020	Cerasus humilis Cherry Polyphenol Reduces High-Fat Diet-Induced Obesity in C57BL/6 Mice by Mitigating Fat Deposition, Inflammation, and Oxidation.	Polyphenols	23-33	CD36 molecule	Mus musculus	102-105
31917277-0	2020	Polyphenols isolated from lychee seed inhibit Alzheimer"s disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3beta pathway.	Polyphenols	0-11	insulin	Homo sapiens	99-106
31917277-10	2020	Molecular docking result further demonstrate that these polyphenols exhibit good binding property with insulin receptor.	Polyphenols	56-67	insulin	Homo sapiens	103-110
31759909-9	2020	CONCLUSIONS: Daily intake of 15g of the legume-based food product improved serum glucose and malondialdehyde levels in the study group, as well as insulin resistance; which could be attributed to the presence of polyphenols and isoflavones such as genistein in legumes.	Polyphenols	212-223	insulin	Homo sapiens	147-154
31927512-3	2020	Certain food components have the potential to act as natural alpha-glucosidase (SCG) inhibitors, such as the polyphenols found in tea.	Polyphenols	109-120	sucrase-isomaltase	Homo sapiens	61-78
32337685-0	2020	Kinetic Characterization of Tyrosinase-catalyzed Oxidation of Four Polyphenols.	Polyphenols	67-78	tyrosinase	Homo sapiens	28-38
32337685-3	2020	Tyrosinase-catalyzed oxidation of four polyphenols as well as its underlying mechanism remains unclear.	Polyphenols	39-50	tyrosinase	Homo sapiens	0-10
32337685-4	2020	In the current work, we investigated the kinetic properties of tyrosinase-catalyzed oxidation of the four polyphenols of interest.	Polyphenols	106-117	tyrosinase	Homo sapiens	63-73
32175596-1	2020	The purpose of this study was to prepare and characterize inclusion complexes between tea polyphenol (TP) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD), and to evaluate their antioxidant properties.	Polyphenols	90-100	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	146-153
31945435-7	2020	The effect of polyphenols on the aggregation kinetics and stability of native TGFbeta3 was also explored.	Polyphenols	14-25	transforming growth factor beta 3	Homo sapiens	78-86
31793191-0	2020	Tea polyphenols alleviate tri-ortho-cresyl phosphate-induced autophagy of mouse ovarian granulosa cells.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
31793191-2	2020	Tea polyphenols (TPs) have multiple health effects via inhibiting oxidative stress.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
32188994-3	2020	Previous studies demonstrated that tea polyphenols attenuate L. pneumophila intracellular replication within mouse macrophages via increased tumor necrosis factor (TNF) production.	Polyphenols	39-50	tumor necrosis factor	Mus musculus	141-162
32188994-3	2020	Previous studies demonstrated that tea polyphenols attenuate L. pneumophila intracellular replication within mouse macrophages via increased tumor necrosis factor (TNF) production.	Polyphenols	39-50	tumor necrosis factor	Mus musculus	164-167
31922618-8	2020	These three polyphenols suppressed Bax/Bcl-2 mRNA ratio, CHOP up-regulation and MMP disruption in NSAIDs-treated cells.	Polyphenols	12-23	BCL2 associated X, apoptosis regulator	Homo sapiens	35-38
32120266-0	2020	Polyphenol-rich green tea extract induces thermogenesis in mice by a mechanism dependent on adiponectin signaling.	Polyphenols	0-10	adiponectin, C1Q and collagen domain containing	Mus musculus	92-103
31922618-8	2020	These three polyphenols suppressed Bax/Bcl-2 mRNA ratio, CHOP up-regulation and MMP disruption in NSAIDs-treated cells.	Polyphenols	12-23	BCL2 apoptosis regulator	Homo sapiens	39-44
31922618-8	2020	These three polyphenols suppressed Bax/Bcl-2 mRNA ratio, CHOP up-regulation and MMP disruption in NSAIDs-treated cells.	Polyphenols	12-23	DNA damage inducible transcript 3	Homo sapiens	57-61
31922618-11	2020	CONCLUSION: The cytoprotective activity of polyphenols against NSAIDs-induced toxicity stemmed from either suppression of CHOP-related ER and mitochondria stresses or other CHOP-independent pathways, but not from the intrinsic ROS scavenging capacity.	Polyphenols	43-54	DNA damage inducible transcript 3	Homo sapiens	122-126
31922618-11	2020	CONCLUSION: The cytoprotective activity of polyphenols against NSAIDs-induced toxicity stemmed from either suppression of CHOP-related ER and mitochondria stresses or other CHOP-independent pathways, but not from the intrinsic ROS scavenging capacity.	Polyphenols	43-54	DNA damage inducible transcript 3	Homo sapiens	173-177
31978263-1	2020	SCOPE: Epigallocatechin gallate (EGCG), an active polyphenol in green tea, exhibits various physiological effects, including activation of low-density lipoprotein receptors (LDLR).	Polyphenols	50-60	low density lipoprotein receptor	Homo sapiens	139-172
31978263-1	2020	SCOPE: Epigallocatechin gallate (EGCG), an active polyphenol in green tea, exhibits various physiological effects, including activation of low-density lipoprotein receptors (LDLR).	Polyphenols	50-60	low density lipoprotein receptor	Homo sapiens	174-178
32028059-0	2020	Young apple polyphenols as natural alpha-glucosidase inhibitors: In vitro and in silico studies.	Polyphenols	12-23	alpha-glucosidase	Malus domestica	35-52
32214146-3	2020	Here, resveratrol (and related polyphenols) is shown to enhance genome stability in mouse embryonic fibroblasts, ultimately protecting the cells against the induction of mutations in the ARF/p53 pathway.	Polyphenols	31-42	transformation related protein 53, pseudogene	Mus musculus	191-194
32032644-0	2020	Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-beta/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo.	Polyphenols	12-22	transforming growth factor alpha	Homo sapiens	78-86
32032644-0	2020	Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-beta/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo.	Polyphenols	12-22	interleukin 6	Homo sapiens	123-127
32032644-0	2020	Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-beta/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo.	Polyphenols	12-22	CD44 molecule (Indian blood group)	Homo sapiens	128-132
32032644-0	2020	Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-beta/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo.	Polyphenols	12-22	signal transducer and activator of transcription 3	Homo sapiens	133-138
32327953-2	2020	The aim of this article was to demonstrate the effects of grape polyphenols on the selected inflammatory mediators, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), and high-sensitivity C-reactive protein (hs-CRP).	Polyphenols	64-75	interleukin 6	Homo sapiens	124-137
32327953-2	2020	The aim of this article was to demonstrate the effects of grape polyphenols on the selected inflammatory mediators, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), and high-sensitivity C-reactive protein (hs-CRP).	Polyphenols	64-75	C-reactive protein	Homo sapiens	227-230
32230810-3	2020	In this study, ALP-loaded gellan gum (GG) hydrogels were enriched with gallotannins, a subclass of polyphenols.	Polyphenols	99-110	alkaline phosphatase, placental	Homo sapiens	15-18
31760852-0	2020	Olive polyphenol reduces the collagen-elicited release of phosphorylated HSP27 from human platelets.	Polyphenols	6-16	heat shock protein family B (small) member 1	Homo sapiens	73-78
31760852-8	2020	These findings suggest that olive polyphenol reduces the collagen-stimulated phosphorylation of HSP27 in human platelets and the release.	Polyphenols	34-44	heat shock protein family B (small) member 1	Homo sapiens	96-101
32028059-1	2020	In this study, the inhibitory activity of young apple polyphenols (YAP) on alpha-glucosidase was investigated.	Polyphenols	54-65	alpha-glucosidase	Malus domestica	75-92
32028059-6	2020	This indicates that binding interactions between polyphenols and alpha-glucosidase caused the enzyme inhibition.	Polyphenols	49-60	alpha-glucosidase	Malus domestica	65-82
32036875-5	2020	In the present review, we highlighted the beneficial actions of polyphenols aimed to diminish the harmful consequences of advanced glycation, mainly by the inhibition of ROS formation during glycation, the inhibition of Schiff base, Amadori products, and subsequent dicarbonyls group formation, the activation of the glyoxalase system, as well as by blocking either AGEs-RAGE interaction or cell signaling.	Polyphenols	64-75	advanced glycosylation end-product specific receptor	Homo sapiens	371-375
31927016-3	2020	NMR spectra from 1D and 2D experiments revealed the sap to contain a single major component, identified as the polyphenol, trifucol.	Polyphenols	111-121	SH2 domain containing 1A	Homo sapiens	52-55
32194324-2	2020	Here, we elucidated binding mechanism between frequently consumed polyphenol "tea catechin" and milk protein bovine beta-lactoglobulin (beta-Lg).	Polyphenols	66-76	casein beta	Bos taurus	96-108
31046599-0	2020	Impact of polyphenols on receptor-ligand interactions by NMR: the case of neurotensin (NT)-neurotensin receptor fragment (NTS1) complex.	Polyphenols	10-21	neurotensin	Homo sapiens	122-126
31823227-0	2020	NF-kappaB-Mediated Neuroinflammation in Parkinson"s Disease and Potential Therapeutic Effect of Polyphenols.	Polyphenols	96-107	nuclear factor kappa B subunit 1	Homo sapiens	0-9
31823227-9	2020	In this aspect, this review highlights the role of NF-kappaB and the possible therapeutic roles of polyphenols in NF-kappaB-mediated neuroinflammation in PD.	Polyphenols	99-110	nuclear factor kappa B subunit 1	Homo sapiens	114-123
32194324-2	2020	Here, we elucidated binding mechanism between frequently consumed polyphenol "tea catechin" and milk protein bovine beta-lactoglobulin (beta-Lg).	Polyphenols	66-76	beta-lactoglobulin	Bos taurus	116-134
32194324-2	2020	Here, we elucidated binding mechanism between frequently consumed polyphenol "tea catechin" and milk protein bovine beta-lactoglobulin (beta-Lg).	Polyphenols	66-76	beta-lactoglobulin	Bos taurus	136-143
32120776-5	2020	This review outlines PKC signaling in autophagy and neurodegenerative disease development and introduces some polyphenols as effectors of PKC isozymes for disease therapy.	Polyphenols	110-121	proline rich transmembrane protein 2	Homo sapiens	138-141
32111098-1	2020	Polyphenols consumption has been associated with a lower risk of cardiovascular diseases (CVDs) notably through nitric oxide (NO)- and estrogen receptor alpha (ERalpha)-dependent pathways.	Polyphenols	0-11	estrogen receptor 1 (alpha)	Mus musculus	135-158
32111098-1	2020	Polyphenols consumption has been associated with a lower risk of cardiovascular diseases (CVDs) notably through nitric oxide (NO)- and estrogen receptor alpha (ERalpha)-dependent pathways.	Polyphenols	0-11	estrogen receptor 1 (alpha)	Mus musculus	160-167
31690989-6	2020	METHODS: As part of two large clinical trials (one designed to investigate the effects of antibiotics, and the other to investigate polyphenol supplementation, on insulin sensitivity), 94 overweight and obese adults (BMI 25-35 kg/m2) previously underwent a two-step hyperinsulinaemic-euglycaemic clamp (using [6,6-2H2]glucose) to assess hepatic and peripheral insulin sensitivity (per cent suppression of endogenous glucose output during the low-insulin-infusion step, and the rate of glucose disappearance during high-insulin infusion [40 mU/(m2 x min)], respectively).	Polyphenols	132-142	insulin	Homo sapiens	163-170
32110986-5	2020	The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p < 0.05).	Polyphenols	4-15	myoglobin	Homo sapiens	49-58
31532659-3	2020	There is accumulating evidence that the administration of polyphenols at doses ranging from 5-180 mg/kg body weight can normalize elevated levels of proinflammatory cytokines and abnormal levels of BDNF and thus restore impaired synaptic plasticity mechanisms that mediate depressive behavior in animal models of stress.	Polyphenols	58-69	brain derived neurotrophic factor	Homo sapiens	198-202
32064033-11	2020	Possible mechanisms include: (1) The abundant dietary fiber contents of WGs increase satiety, satiation, energy excretion from stool, and energy expenditure simultaneously decreasing energy absorption and fat storage; (2) The plentiful amount of polyphenols of WGs improve energy expenditure by hampering adipocyte maturation and function; (3) The sufficient magnesium and zinc of WGs guarantee lean body mass growth and decrease fat mass; (4) The effect of WGs on brown adipose tissue is a key component of non-shivering thermogenesis; and (5) The increase of adiponectin by WGs enhances glucose utilization, lipid oxidation, and energy expenditure.	Polyphenols	246-257	adiponectin, C1Q and collagen domain containing	Homo sapiens	561-572
32075202-2	2020	In our previous study, we demonstrated that coffee polyphenols (CPP) prevent cognitive dysfunction and Abeta deposition in the brain of an APP/PS2 transgenic mouse AD model.	Polyphenols	51-62	trefoil factor 1	Mus musculus	143-146
32172946-0	2020	Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway.	Polyphenols	10-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-110
32172946-0	2020	Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway.	Polyphenols	10-21	heme oxygenase 1	Mus musculus	111-115
31939603-2	2020	Naturally occurring small molecules such as polyphenols have emerged as promising inhibitors of alpha-Syn fibrillation and toxicity and could be potential therapeutic agents against PD.	Polyphenols	44-55	synemin	Homo sapiens	102-105
31974389-9	2020	Thanks to their biphasic activity of antioxidant in normal cells undergoing stressful conditions and pro-oxidant in cancer cells, these polyphenols probably engage an interplay among the key factors Nrf-2, NF-kappaB, STAT-3 and p53.	Polyphenols	136-147	nuclear factor kappa B subunit 1	Homo sapiens	206-215
31968404-6	2020	PRACTICAL APPLICATION: Orange peels are valuable sources of natural antioxidants such as polyphenols.	Polyphenols	89-100	PRAC1 small nuclear protein	Homo sapiens	0-9
31904507-0	2020	Therapeutic potential of polyphenols in cardiovascular diseases: regulation of mTOR signaling pathway.	Polyphenols	25-36	mechanistic target of rapamycin kinase	Homo sapiens	79-83
31904507-7	2020	In the present review, we intend to shed light on the possible effects and molecular mechanism of natural agents like polyphenols via regulating mTOR.	Polyphenols	118-129	mechanistic target of rapamycin kinase	Homo sapiens	145-149
31894808-2	2020	In our study, bovine alpha-lactalbumin was cross-linked by polyphenol oxidase from Agaricus bisporus and the changes in the structure, digestibility and allergenicity of alpha-lactalbumin were explored after cross-linking, and the structural alterations of the polymers were analyzed by circular dichroism spectroscopy, ultraviolet absorption spectroscopy and fluorescence spectroscopy.	Polyphenols	59-69	lactalbumin alpha	Bos taurus	21-38
31894808-2	2020	In our study, bovine alpha-lactalbumin was cross-linked by polyphenol oxidase from Agaricus bisporus and the changes in the structure, digestibility and allergenicity of alpha-lactalbumin were explored after cross-linking, and the structural alterations of the polymers were analyzed by circular dichroism spectroscopy, ultraviolet absorption spectroscopy and fluorescence spectroscopy.	Polyphenols	59-69	lactalbumin alpha	Bos taurus	170-187
31974389-3	2020	We reported that both polyphenols show antioxidant and oto-protective activity in the cochlea by up-regulating Nrf-2/HO-1 pathway and downregulating p53 phosphorylation.	Polyphenols	22-33	NFE2 like bZIP transcription factor 2	Homo sapiens	111-116
31974389-3	2020	We reported that both polyphenols show antioxidant and oto-protective activity in the cochlea by up-regulating Nrf-2/HO-1 pathway and downregulating p53 phosphorylation.	Polyphenols	22-33	heme oxygenase 1	Homo sapiens	117-121
31974389-9	2020	Thanks to their biphasic activity of antioxidant in normal cells undergoing stressful conditions and pro-oxidant in cancer cells, these polyphenols probably engage an interplay among the key factors Nrf-2, NF-kappaB, STAT-3 and p53.	Polyphenols	136-147	signal transducer and activator of transcription 3	Homo sapiens	217-223
31974389-3	2020	We reported that both polyphenols show antioxidant and oto-protective activity in the cochlea by up-regulating Nrf-2/HO-1 pathway and downregulating p53 phosphorylation.	Polyphenols	22-33	tumor protein p53	Homo sapiens	149-152
31974389-9	2020	Thanks to their biphasic activity of antioxidant in normal cells undergoing stressful conditions and pro-oxidant in cancer cells, these polyphenols probably engage an interplay among the key factors Nrf-2, NF-kappaB, STAT-3 and p53.	Polyphenols	136-147	tumor protein p53	Homo sapiens	228-231
31974389-9	2020	Thanks to their biphasic activity of antioxidant in normal cells undergoing stressful conditions and pro-oxidant in cancer cells, these polyphenols probably engage an interplay among the key factors Nrf-2, NF-kappaB, STAT-3 and p53.	Polyphenols	136-147	NFE2 like bZIP transcription factor 2	Homo sapiens	199-204
31512490-0	2020	Targeting NF-kappaB signaling pathway in cancer by dietary polyphenols.	Polyphenols	59-70	nuclear factor kappa B subunit 1	Homo sapiens	10-19
31901900-2	2020	When exploring the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs, exposure to the dietary polyphenol resveratrol (RSV) revealed its differential capacity to generate a distinct PD-L1 electrophoretic migration pattern.	Polyphenols	121-131	CD274 molecule	Homo sapiens	208-213
31901900-7	2020	This unforeseen immunomodulating mechanism of RSV might illuminate new approaches to restore T-cell function by targeting the PD-1/PD-L1 immunologic checkpoint with natural polyphenols.	Polyphenols	173-184	programmed cell death 1	Homo sapiens	126-130
31901900-7	2020	This unforeseen immunomodulating mechanism of RSV might illuminate new approaches to restore T-cell function by targeting the PD-1/PD-L1 immunologic checkpoint with natural polyphenols.	Polyphenols	173-184	CD274 molecule	Homo sapiens	131-136
32601944-7	2020	Herein we review the published literature of the most studied polyphenols, in particular for their ability to remodel the hIAPP aggregation pathway, to rescue the in vitro pancreatic beta-cell viability and function, as well as to perform under a complex biological environment, i.e., in vivo animal models and clinical trials.	Polyphenols	62-73	islet amyloid polypeptide	Homo sapiens	122-127
32601944-8	2020	Overall, natural polyphenols are able to control the cytotoxic hIAPP aggregation and minimize hIAPP-mediated cellular dysfunction and can be considered as important lead compounds for the treatment of type-2 diabetes.	Polyphenols	17-28	islet amyloid polypeptide	Homo sapiens	63-68
32601944-8	2020	Overall, natural polyphenols are able to control the cytotoxic hIAPP aggregation and minimize hIAPP-mediated cellular dysfunction and can be considered as important lead compounds for the treatment of type-2 diabetes.	Polyphenols	17-28	islet amyloid polypeptide	Homo sapiens	94-99
31979098-11	2020	Conclusions: Grape polyphenols exert a favorable effect on lipid profile in humans by significantly reducing plasma levels of LDL-C and oxLDL-C.	Polyphenols	19-30	component of oligomeric golgi complex 2	Homo sapiens	126-131
31829012-0	2020	Beneficial Effects of Dietary Polyphenols on High-Fat Diet-Induced Obesity Linking with Modulation of Gut Microbiota.	Polyphenols	30-41	FAT atypical cadherin 1	Homo sapiens	50-53
31998443-0	2020	Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1.	Polyphenols	10-21	flap structure-specific endonuclease 1	Homo sapiens	121-140
31004736-0	2020	Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.	Polyphenols	23-34	tumor protein p53	Homo sapiens	49-52
31004736-1	2020	The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53).	Polyphenols	26-37	tumor protein p53	Homo sapiens	117-133
31004736-1	2020	The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53).	Polyphenols	26-37	tumor protein p53	Homo sapiens	135-138
31004736-3	2020	A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action.	Polyphenols	12-23	tumor protein p53	Homo sapiens	80-83
31004736-4	2020	The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.	Polyphenols	125-136	tumor protein p53	Homo sapiens	170-173
30799629-6	2020	We can conclude that the retarded starch digestion in vitro by polyphenols results from inhibition of key digestive enzymes, including alpha-amylase and alpha-glucosidase, as well as from interactions between polyphenols and starch.	Polyphenols	63-74	sucrase-isomaltase	Homo sapiens	153-170
31512490-5	2020	Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-kappaB signaling pathway.	Polyphenols	0-11	nuclear factor kappa B subunit 1	Homo sapiens	122-131
31512490-7	2020	Through inhibition of NF-kappaB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis.	Polyphenols	33-44	nuclear factor kappa B subunit 1	Homo sapiens	22-31
31512490-8	2020	This review highlights the anticancer effects of polyphenols on the basis of NF-kappaB signaling pathway regulation.	Polyphenols	49-60	nuclear factor kappa B subunit 1	Homo sapiens	77-86
32611294-7	2020	The suggested mechanisms by which polyphenols can modulate thermogenesis include Nor-epinephrine/Catechol-O-Methyl-Transferase (NE/COMT) inhibition, PPARgamma co-activator alpha (PGC-1alpha)-dependent pathways activation, mitochondrial biogenesis, among others.	Polyphenols	34-45	catechol-O-methyltransferase	Homo sapiens	131-135
31934839-6	2020	Here, recent data on the suitability of the LPS-induced murine neuroinflammation model for preclinical assessment of a large number of nutraceuticals belonging to different groups of natural products such as flavonoids, terpenes, non-flavonoid polyphenols, glycosides, heterocyclic compounds, organic acids, organosulfur compounds and xanthophylls, are summarized.	Polyphenols	244-255	toll-like receptor 4	Mus musculus	44-47
32611294-7	2020	The suggested mechanisms by which polyphenols can modulate thermogenesis include Nor-epinephrine/Catechol-O-Methyl-Transferase (NE/COMT) inhibition, PPARgamma co-activator alpha (PGC-1alpha)-dependent pathways activation, mitochondrial biogenesis, among others.	Polyphenols	34-45	PPARG coactivator 1 alpha	Homo sapiens	179-189
31883611-3	2020	Mulberry fruits containing polyphenols to remove free radicals and mitigate inflammation has been reported to not only against gastric cancer, melanoma and leukemia but also prevent liver injury induced by alcohol or CCl4 in previous researches.	Polyphenols	27-38	C-C motif chemokine ligand 4	Homo sapiens	217-221
31782370-7	2020	In particular, polyphenols are able to decrease serum levels of interleukin (IL)-17, while increasing levels of IL-10.	Polyphenols	15-26	interleukin 17A	Homo sapiens	64-83
31782370-7	2020	In particular, polyphenols are able to decrease serum levels of interleukin (IL)-17, while increasing levels of IL-10.	Polyphenols	15-26	interleukin 10	Homo sapiens	112-117
31882076-0	2020	Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation.	Polyphenols	10-21	NLR family, pyrin domain containing 3	Mus musculus	152-157
31441735-8	2020	KEY FINDINGS: The natural polyphenol curcumin could downregulate the expressions levels of Ki67 and EGFR both in vitro and in vivo.	Polyphenols	26-36	antigen identified by monoclonal antibody Ki 67	Mus musculus	91-95
31441735-8	2020	KEY FINDINGS: The natural polyphenol curcumin could downregulate the expressions levels of Ki67 and EGFR both in vitro and in vivo.	Polyphenols	26-36	epidermal growth factor receptor	Mus musculus	100-104
31888113-0	2019	Endoplasmic Reticulum Stress-Induced Resistance to Doxorubicin Is Reversed by Mulberry Leaf Polyphenol Extract in Hepatocellular Carcinoma through Inhibition of COX-2.	Polyphenols	92-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	161-166
31665823-0	2020	Translating In Vitro Acrolein-Trapping Capacities of Tea Polyphenol and Soy Genistein to In Vivo Situation is Mediated by the Bioavailability and Biotransformation of Individual Polyphenols.	Polyphenols	57-67	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	53-56
31665823-0	2020	Translating In Vitro Acrolein-Trapping Capacities of Tea Polyphenol and Soy Genistein to In Vivo Situation is Mediated by the Bioavailability and Biotransformation of Individual Polyphenols.	Polyphenols	178-189	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	53-56
31906027-3	2019	The present study was designed to investigate the effect of marineomega-3 polyunsaturated fatty acids (PUFAs) (eicosapentaenoic acid (EPA) and docosahexaenoic acid(DHA)) and their combination with grape seed polyphenols (GSE) on carbonyl-modified proteins fromplasma and liver in Wistar Kyoto rats fed an obesogenic diet, namely high-fat and high-sucrose (HFHS)diet.	Polyphenols	208-219	FAT atypical cadherin 1	Rattus norvegicus	90-93
31436500-5	2020	Using mouse macrophage cells (RAW 264.7), we examined whether tart cherry polyphenols could dose dependently inhibit the proliferation and activity of receptor activator of nuclear factor kappa-B ligand (RANKL) differentiated osteoclasts under inflammatory conditions.	Polyphenols	74-85	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	151-202
31436500-5	2020	Using mouse macrophage cells (RAW 264.7), we examined whether tart cherry polyphenols could dose dependently inhibit the proliferation and activity of receptor activator of nuclear factor kappa-B ligand (RANKL) differentiated osteoclasts under inflammatory conditions.	Polyphenols	74-85	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	204-209
31436500-6	2020	Tartrate-resistant acid phosphatase (TRAP) activity and staining of TRAP-positive multinucleated cells, used as indicators of osteoclast differentiation and activity, tended to decrease with tart cherry polyphenols treatment.	Polyphenols	203-214	acid phosphatase 5, tartrate resistant	Mus musculus	0-35
31436500-6	2020	Tartrate-resistant acid phosphatase (TRAP) activity and staining of TRAP-positive multinucleated cells, used as indicators of osteoclast differentiation and activity, tended to decrease with tart cherry polyphenols treatment.	Polyphenols	203-214	acid phosphatase 5, tartrate resistant	Mus musculus	37-41
31436500-6	2020	Tartrate-resistant acid phosphatase (TRAP) activity and staining of TRAP-positive multinucleated cells, used as indicators of osteoclast differentiation and activity, tended to decrease with tart cherry polyphenols treatment.	Polyphenols	203-214	acid phosphatase 5, tartrate resistant	Mus musculus	68-72
32863301-9	2020	Moreover, polyphenols such as cyanidin-3-glucoside chloride and quercetin enhanced the SVCT1 gene expression in Caco-2 cells.	Polyphenols	10-21	solute carrier family 23 member 1	Homo sapiens	87-92
31755209-5	2020	Dietary nut exposure is characterized by urinary metabolites of polyphenols and fatty acids pathways.	Polyphenols	64-75	NUT midline carcinoma family member 1	Homo sapiens	8-11
32569536-9	2020	Results: We demonstrate that the fluorescence of betel nut exposed cells is greater than that of cells exposed to other optically active compounds such as polyphenol-rich foods.	Polyphenols	155-165	NUT midline carcinoma family member 1	Homo sapiens	55-58
32569536-10	2020	We also demonstrate that the fluorescence spectra of betel nut quid exposed cells are distinct from that of cells exposed to other polyphenol-rich substances.	Polyphenols	131-141	NUT midline carcinoma family member 1	Homo sapiens	59-62
31696185-11	2019	In conclusion, the comparative study on the interaction of oxyresveratrol and piceatannol with trypsin and lysozyme showed that the positions of hydroxyl groups of the polyphenols had an important influence on their interaction with enzymes and their antioxidant activity and stability as well as the enzyme activities.	Polyphenols	168-179	lysozyme	Homo sapiens	107-115
31878222-7	2019	The literature also provides evidence that polyphenol-rich diets can modulate the expression of genes involved in insulin secretion, insulin signalling, and liver gluconeogenesis pathways.	Polyphenols	43-53	insulin	Homo sapiens	114-121
31878222-7	2019	The literature also provides evidence that polyphenol-rich diets can modulate the expression of genes involved in insulin secretion, insulin signalling, and liver gluconeogenesis pathways.	Polyphenols	43-53	insulin	Homo sapiens	133-140
31861147-0	2019	Bioactive Polyphenols Modulate Enzymes Involved in Grapevine Pathogenesis and Chitinase Activity at Increasing Complexity Levels.	Polyphenols	10-21	acidic endochitinase	Vitis vinifera	78-87
31746899-10	2019	Regarding the putative underlying mechanism, GLP-1 secreted from intestinal cells by the polyphenols in BE activates eNOS in vascular endothelial cells.	Polyphenols	89-100	nitric oxide synthase 3	Rattus norvegicus	117-121
31773117-2	2019	Curcumin, a dietary polyphenol isolated from the rhizome of turmeric, has been found to have therapeutic benefits in chronic obstructive pulmonary disease (COPD) via inhibiting NF-kappaB.	Polyphenols	20-30	nuclear factor kappa B subunit 1	Homo sapiens	177-186
31817413-0	2019	Anti-Atherosclerotic Effect of Hibiscus Leaf Polyphenols against Tumor Necrosis Factor-alpha-Induced Abnormal Vascular Smooth Muscle Cell Migration and Proliferation.	Polyphenols	45-56	tumor necrosis factor	Rattus norvegicus	65-92
31920684-8	2019	Furthermore, tea polyphenols could increase the antioxidant capacities and expressions of p-ATM and p-Chk2 and then attenuate DNA damage via activating the DNA repair signaling pathway.	Polyphenols	17-28	ATM serine/threonine kinase	Rattus norvegicus	92-95
31817563-0	2019	Lemon Peel Polyphenol Extract Reduces Interleukin-6-Induced Cell Migration, Invasiveness, and Matrix Metalloproteinase-9/2 Expression in Human Gastric Adenocarcinoma MKN-28 and AGS Cell Lines.	Polyphenols	11-21	interleukin 6	Homo sapiens	38-51
31817563-0	2019	Lemon Peel Polyphenol Extract Reduces Interleukin-6-Induced Cell Migration, Invasiveness, and Matrix Metalloproteinase-9/2 Expression in Human Gastric Adenocarcinoma MKN-28 and AGS Cell Lines.	Polyphenols	11-21	matrix metallopeptidase 9	Homo sapiens	94-120
31920684-8	2019	Furthermore, tea polyphenols could increase the antioxidant capacities and expressions of p-ATM and p-Chk2 and then attenuate DNA damage via activating the DNA repair signaling pathway.	Polyphenols	17-28	checkpoint kinase 2	Rattus norvegicus	102-106
30573355-0	2019	Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: A pilot study.	Polyphenols	13-24	insulin	Homo sapiens	33-40
30573355-2	2019	We aimed to evaluate: 1) the acute effects of the consumption of a drink rich in polyphenols from red grape pomace (RGPD) on glucose/insulin and triglyceride responses to a standard meal in healthy individuals, and, 2) the relationship between plasma levels of phenolic metabolites and metabolic parameters.	Polyphenols	81-92	insulin	Homo sapiens	133-140
31812985-3	2019	Evidence indicates that polyphenol neuroprotection may be mediated by activation of Nrf2, a transcription factor associated with antioxidant and cell survival responses.	Polyphenols	24-34	NFE2 like bZIP transcription factor 2	Homo sapiens	84-88
31499117-3	2019	In this work, we have tried the naturally occurring polyphenol, curcumin, for probing the aggregation of the serum protein bovine serum albumin (BSA) in crowded environments.	Polyphenols	52-62	albumin	Homo sapiens	130-143
31580947-7	2019	Interestingly, we found that plant extracts containing polyphenol antioxidants provided further protection against the growth defects of the tsa1tsa2Delta strain expressing hPrx and preserved the peroxidase-active forms of the Prxs.	Polyphenols	55-65	periaxin	Homo sapiens	173-177
31812985-12	2019	CONCLUSIONS: These results suggest that naturally derived polyphenols protect cortical cells against corticosterone-induced cytotoxicity and enhance cell survival via modulation of the Nrf2 pathway and expression of Fkbp5.	Polyphenols	58-69	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
31812985-12	2019	CONCLUSIONS: These results suggest that naturally derived polyphenols protect cortical cells against corticosterone-induced cytotoxicity and enhance cell survival via modulation of the Nrf2 pathway and expression of Fkbp5.	Polyphenols	58-69	FKBP prolyl isomerase 5	Homo sapiens	216-221
31812985-9	2019	Basal levels of Bdnf mRNA were also decreased after corticosterone insult; however, this was reversed by both polyphenol treatments.	Polyphenols	110-120	brain derived neurotrophic factor	Homo sapiens	16-20
31393601-0	2019	Binding characteristics of polyphenols as milk plasmin inhibitors.	Polyphenols	27-38	plasminogen	Homo sapiens	47-54
30696301-6	2019	Our results establish ellagitannins as partially selective inhibitors of PP1 and indicate that these polyphenols may act distinctly in cellular systems depending on their membrane permeability and/or their actions on cell membranes.	Polyphenols	101-112	inorganic pyrophosphatase 1	Homo sapiens	73-76
31393601-4	2019	The objective of this study was to assess the ability of polyphenols to inhibit plasmin in milk using a molecular and kinetic approach.	Polyphenols	57-68	plasminogen	Homo sapiens	80-87
31757048-1	2019	Ginkgetin, a biflavone from Ginkgo biloba leaf, and resveratrol, a polyphenol found in grape and wine, are two phytochemicals being identified for its binding to vascular endothelial growth factor (VEGF): the binding, therefore, resulted in the alteration of the physiological roles of VEGF-mediated angiogenesis.	Polyphenols	67-77	vascular endothelial growth factor A	Homo sapiens	198-202
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	myeloperoxidase	Rattus norvegicus	102-105
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	interleukin 6	Rattus norvegicus	190-194
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	tumor necrosis factor	Rattus norvegicus	196-205
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	transforming growth factor, beta 1	Rattus norvegicus	211-220
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	interleukin 1 alpha	Rattus norvegicus	254-262
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	interleukin 6	Rattus norvegicus	264-268
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	tumor necrosis factor	Rattus norvegicus	270-279
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	interferon gamma	Rattus norvegicus	285-294
31533201-5	2019	The results show that pretreatments with honey polyphenols significantly improve SOD, GSH-Px, NO, and MPO levels and reduce DSS-induced colonic apoptosis, the colonic inflammatory cytokines IL-6, TNF-alpha, and TGF-beta1 accompanied by downregulation of IL-1beta, IL-6, TNF-alpha, and IFN-gamma gene and upregulation of IkappaB-alpha gene.	Polyphenols	47-58	NFKB inhibitor alpha	Rattus norvegicus	320-333
31521398-12	2019	Polyphenols from fruits and vegetables modulate tau hyperphosphorylation and beta amyloid aggregation in animal models of Alzheimer disease.	Polyphenols	0-11	microtubule associated protein tau	Homo sapiens	48-51
31783532-9	2019	The modulation of tumor PD-L1 by flavonoids or polyphenols is proposed to improve the response to PLB in low PD-L1 tumors.	Polyphenols	47-58	CD274 molecule	Homo sapiens	109-114
31392548-0	2019	Correction to: Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.	Polyphenols	41-52	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	66-82
31392548-0	2019	Correction to: Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.	Polyphenols	41-52	AKT serine/threonine kinase 1	Rattus norvegicus	129-132
31392548-0	2019	Correction to: Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.	Polyphenols	41-52	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	137-140
31783532-4	2019	Recently, we show upregulation of PD-L1 in cancer cells by >=IC50 supra-pharmacological dose of grape polyphenol resveratrol and piceatannol, alone and combined.	Polyphenols	102-112	CD274 molecule	Homo sapiens	34-39
31783532-5	2019	Herein, we summarize recent published studies on the regulation of tumor PD-L1 by flavonoids and grape polyphenols.	Polyphenols	103-114	CD274 molecule	Homo sapiens	73-78
31783532-9	2019	The modulation of tumor PD-L1 by flavonoids or polyphenols is proposed to improve the response to PLB in low PD-L1 tumors.	Polyphenols	47-58	CD274 molecule	Homo sapiens	24-29
31783532-9	2019	The modulation of tumor PD-L1 by flavonoids or polyphenols is proposed to improve the response to PLB in low PD-L1 tumors.	Polyphenols	47-58	phospholamban	Homo sapiens	98-101
31603646-0	2019	Biophysical and in vivo studies identify a new natural-based polyphenol, counteracting Abeta oligomerization in vitro and Abeta oligomer-mediated memory impairment and neuroinflammation in an acute mouse model of Alzheimer"s disease.	Polyphenols	61-71	histocompatibility 2, class II antigen A, beta 1	Mus musculus	87-92
31773068-7	2019	Methods: A course of antibiotics (clindamycin, piperacillin/tazobactam, or aztreonam) was administered SC daily (days 1 and 2) to mice receiving polyphenol-rich green tea in drinking water.	Polyphenols	145-155	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	167-170
31642672-3	2019	The purified polyphenol extracts exhibited good antioxidant activities, alpha-glucosidase and lipase inhibition activities (IC50 < 0.25 mg/mL).	Polyphenols	13-23	lipase G, endothelial type	Rattus norvegicus	94-100
31608624-0	2019	Apple Polyphenols Extract Alleviates High-Fat-Diet Induced Hepatic Steatosis in Male C57BL/6 mice by targeting LKB1/AMPK Pathway.	Polyphenols	6-17	serine/threonine kinase 11	Mus musculus	111-115
31482617-0	2019	Recent Advances of Natural Polyphenols Activators for Keap1-Nrf2 Signaling Pathway.	Polyphenols	27-38	kelch like ECH associated protein 1	Homo sapiens	54-59
31074515-0	2019	Grape-derived polyphenols produce antidepressant effects via VGF- and BDNF-dependent mechanisms.	Polyphenols	14-25	VGF nerve growth factor inducible	Mus musculus	61-64
31074515-0	2019	Grape-derived polyphenols produce antidepressant effects via VGF- and BDNF-dependent mechanisms.	Polyphenols	14-25	brain derived neurotrophic factor	Mus musculus	70-74
31437460-1	2019	BACKGROUND: Flavonoids form a diverse class of naturally occurring polyphenols ascribed various biological activities, including inhibition of amyloid beta (Abeta) fibrillisation and neurotoxicity of relevance to Alzheimer"s disease.	Polyphenols	67-78	amyloid beta precursor protein	Rattus norvegicus	157-162
31482617-5	2019	In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1-Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered.	Polyphenols	52-63	NFE2 like bZIP transcription factor 2	Homo sapiens	218-222
31694323-0	2019	Conformation and Aggregation of Human Serum Albumin in the Presence of Green Tea Polyphenol (EGCg) and/or Palmitic Acid.	Polyphenols	81-91	albumin	Homo sapiens	38-51
31694323-13	2019	Any of these effects could impact the ability of serum albumin to transport and stabilize ligands including EGCg and other polyphenols.	Polyphenols	123-134	albumin	Homo sapiens	49-62
31615832-9	2019	Plant-based polyphenols make up the largest class of hit compounds and NRF2 inducers.	Polyphenols	12-23	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
31728502-4	2019	In this comprehensive review, we examine studies in humans of plant-based dietary patterns and polyphenol-rich plant foods and their role in either preventing ARCD and/or improving cognitive function.	Polyphenols	95-105	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	159-163
31482617-5	2019	In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1-Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered.	Polyphenols	184-195	kelch like ECH associated protein 1	Homo sapiens	130-135
31482617-5	2019	In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1-Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered.	Polyphenols	184-195	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
31482617-0	2019	Recent Advances of Natural Polyphenols Activators for Keap1-Nrf2 Signaling Pathway.	Polyphenols	27-38	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
31482617-5	2019	In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1-Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered.	Polyphenols	184-195	NFE2 like bZIP transcription factor 2	Homo sapiens	218-222
31482617-6	2019	In this view, we summarize the research status of natural polyphenols that have been found with apparent Nrf2 activation and their action modes.	Polyphenols	58-69	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
31482617-4	2019	Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1-Nrf2 protein-protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway.	Polyphenols	12-23	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
31482617-4	2019	Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1-Nrf2 protein-protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway.	Polyphenols	12-23	kelch like ECH associated protein 1	Homo sapiens	97-102
31482617-4	2019	Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1-Nrf2 protein-protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway.	Polyphenols	12-23	NFE2 like bZIP transcription factor 2	Homo sapiens	103-107
31482617-4	2019	Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1-Nrf2 protein-protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway.	Polyphenols	12-23	kelch like ECH associated protein 1	Homo sapiens	154-159
31482617-4	2019	Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1-Nrf2 protein-protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway.	Polyphenols	12-23	NFE2 like bZIP transcription factor 2	Homo sapiens	103-107
31741512-5	2019	Under these conditions, the highest yields of polyphenol, the total phenolic content (15.24 mg GAE/g), total anthocyanins content (346.68 mg CGE/100 g) in grape skin, were obtained with significant antioxidant properties by DPPH, ABTS and FRAP assays.	Polyphenols	46-56	mechanistic target of rapamycin kinase	Homo sapiens	239-243
31418340-0	2019	Polyphenols targeting diabetes via the AMP-activated protein kinase pathway; future approach to drug discovery.	Polyphenols	0-11	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	39-67
31418340-5	2019	While there are several publications on this subject, this is the first report that has focused solely on polyphenols targeting diabetes via AMPK pathway.	Polyphenols	106-117	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	141-145
31253292-0	2019	Five individual polyphenols as tyrosinase inhibitors: Inhibitory activity, synergistic effect, action mechanism, and molecular docking.	Polyphenols	16-27	tyrosinase	Homo sapiens	31-41
31253292-6	2019	Molecular docking suggested that three polyphenols from Group 11 have synergistic effect on tyrosinase.	Polyphenols	39-50	tyrosinase	Homo sapiens	92-102
31410984-1	2019	SCOPE: Polyphenols exhibit their antioxidant activity downstream the activation of the nuclear factor erythroid 2-related factor 2 pathway (Nrf2), but the connection between lipid metabolism and the Nrf2 pathway is still unknown.	Polyphenols	7-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-130
31393642-0	2019	Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-kappaB Pathway.	Polyphenols	18-29	nuclear factor kappa B subunit 1	Homo sapiens	122-131
31393642-4	2019	Thymic stromal lymphopoietin (TSLP), measured by ELISA, is attenuated by both polyphenols in a dose-dependent manner.	Polyphenols	78-89	thymic stromal lymphopoietin	Homo sapiens	0-28
31393642-4	2019	Thymic stromal lymphopoietin (TSLP), measured by ELISA, is attenuated by both polyphenols in a dose-dependent manner.	Polyphenols	78-89	thymic stromal lymphopoietin	Homo sapiens	30-34
31410984-1	2019	SCOPE: Polyphenols exhibit their antioxidant activity downstream the activation of the nuclear factor erythroid 2-related factor 2 pathway (Nrf2), but the connection between lipid metabolism and the Nrf2 pathway is still unknown.	Polyphenols	7-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	140-144
31661763-0	2019	Polyphenol Effects on Cholesterol Metabolism via Bile Acid Biosynthesis, CYP7A1: A Review.	Polyphenols	0-10	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	73-79
31661763-7	2019	Importantly, we will address the following questions: (1) Can polyphenols enhance BA secretion by modulating the CYP7A1 biosynthetic pathway?	Polyphenols	62-73	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	113-119
31661763-10	2019	We conclude that while in rodents some polyphenols induce CYP7A1 expression predominantly by the LXRalpha pathway, in human cells, this may occur through FXR, NF-KB, and ERK signalling.	Polyphenols	39-50	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	58-64
31661763-10	2019	We conclude that while in rodents some polyphenols induce CYP7A1 expression predominantly by the LXRalpha pathway, in human cells, this may occur through FXR, NF-KB, and ERK signalling.	Polyphenols	39-50	nuclear receptor subfamily 1 group H member 3	Homo sapiens	97-105
31661763-10	2019	We conclude that while in rodents some polyphenols induce CYP7A1 expression predominantly by the LXRalpha pathway, in human cells, this may occur through FXR, NF-KB, and ERK signalling.	Polyphenols	39-50	nuclear receptor subfamily 1 group H member 4	Homo sapiens	154-157
31661763-10	2019	We conclude that while in rodents some polyphenols induce CYP7A1 expression predominantly by the LXRalpha pathway, in human cells, this may occur through FXR, NF-KB, and ERK signalling.	Polyphenols	39-50	mitogen-activated protein kinase 1	Homo sapiens	170-173
31590417-0	2019	The Effect of Polyphenols on Hypercholesterolemia through Inhibiting the Transport and Expression of Niemann-Pick C1-Like 1.	Polyphenols	14-25	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	101-123
31586435-1	2019	BACKGROUND The purpose of the present research is to analyze the effect of polyphenols and flavonoids substrat (PFS) from plants Calendula officinalis, Salvia fruticosa, Achillea millefolium, and propolis as immunomodulatory in the production of interleukin (IL)-1ss and IL-10 in peripheral blood leukocytes medium (PBLM) in patients who were diagnosed with mucositis of peri-implant tissue compared to patients with healthy implant tissue.	Polyphenols	75-86	interleukin 10	Homo sapiens	271-276
31590417-2	2019	This report describes the discovery of NPC1L1, its transport properties, and the inhibitory effects of polyphenols on NPC1L1.	Polyphenols	103-114	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	118-124
31590417-6	2019	Some polyphenols, particularly luteolin, have been reported as NPC1L1-mediated anti-dyslipidemia constituents.	Polyphenols	5-16	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	63-69
31590417-12	2019	This review also explores the effect of other polyphenols on NPC1L1 and hypercholesterolemia.	Polyphenols	46-57	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	61-67
31378934-5	2019	KEY RESULTS: Among a set of polyphenol metabolites, we found that exposure of INS-1 beta-cells to urolithins A and C enhanced glucose-stimulated insulin secretion.	Polyphenols	28-38	insulin 1	Rattus norvegicus	78-83
31125704-3	2019	Here, we investigated the effects of a library of food polyphenols on 5-lipoxygenase (5-LOX) activity in a cell-free assay, and in human neutrophils.	Polyphenols	55-66	arachidonate 5-lipoxygenase	Homo sapiens	70-84
31352240-2	2019	Using a virtual screening approach and in vitro studies, we have identified the ellagic acid (EA), a dietary polyphenol, as a potent inhibitor of SphK1.	Polyphenols	109-119	sphingosine kinase 1	Homo sapiens	146-151
31591287-3	2019	However, due to the low concentration in biological fluids in vivo, the antioxidant properties of polyphenols seem to be related to an enhanced endogenous antioxidant capacity induced via signaling through the nuclear respiratory factor 2 pathway.	Polyphenols	98-109	GA binding protein transcription factor subunit beta 1	Homo sapiens	210-238
31279520-5	2019	Furthermore, not only tyrosinase has been used to produce useful polyphenol derivatives, but also it is recently revealed that the promiscuous activity of tyrosinase is closely related with delignification in the biorefinery.	Polyphenols	65-75	tyrosinase	Homo sapiens	22-32
31279520-5	2019	Furthermore, not only tyrosinase has been used to produce useful polyphenol derivatives, but also it is recently revealed that the promiscuous activity of tyrosinase is closely related with delignification in the biorefinery.	Polyphenols	65-75	tyrosinase	Homo sapiens	155-165
31546671-7	2019	However, PB2 prevented the decrease in occludin expression and both polyphenols produced a huge increase in CL-7 abundance.	Polyphenols	68-79	claudin 7	Homo sapiens	108-112
32274480-0	2019	[Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1beta and IL-17F in patients with early peri-implant soft tissue inflammation].	Polyphenols	57-68	interleukin 1 alpha	Homo sapiens	86-94
32274480-0	2019	[Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1beta and IL-17F in patients with early peri-implant soft tissue inflammation].	Polyphenols	57-68	interleukin 17F	Homo sapiens	99-105
31557846-5	2019	The transported polyphenols were able to prevent IL-8 production and suppress the gene expression of proinflammatory mediators (TNF-alpha, ICAM-1, VCAM-1, and COX-2) in the TNF-alpha or oxidized low-density lipoprotein (ox-LDL) treated EA.hy926 cells.	Polyphenols	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
31557846-5	2019	The transported polyphenols were able to prevent IL-8 production and suppress the gene expression of proinflammatory mediators (TNF-alpha, ICAM-1, VCAM-1, and COX-2) in the TNF-alpha or oxidized low-density lipoprotein (ox-LDL) treated EA.hy926 cells.	Polyphenols	16-27	tumor necrosis factor	Homo sapiens	128-137
31557846-5	2019	The transported polyphenols were able to prevent IL-8 production and suppress the gene expression of proinflammatory mediators (TNF-alpha, ICAM-1, VCAM-1, and COX-2) in the TNF-alpha or oxidized low-density lipoprotein (ox-LDL) treated EA.hy926 cells.	Polyphenols	16-27	intercellular adhesion molecule 1	Homo sapiens	139-145
31557846-5	2019	The transported polyphenols were able to prevent IL-8 production and suppress the gene expression of proinflammatory mediators (TNF-alpha, ICAM-1, VCAM-1, and COX-2) in the TNF-alpha or oxidized low-density lipoprotein (ox-LDL) treated EA.hy926 cells.	Polyphenols	16-27	vascular cell adhesion molecule 1	Homo sapiens	147-153
31557846-5	2019	The transported polyphenols were able to prevent IL-8 production and suppress the gene expression of proinflammatory mediators (TNF-alpha, ICAM-1, VCAM-1, and COX-2) in the TNF-alpha or oxidized low-density lipoprotein (ox-LDL) treated EA.hy926 cells.	Polyphenols	16-27	prostaglandin-endoperoxide synthase 2	Homo sapiens	159-164
31557846-5	2019	The transported polyphenols were able to prevent IL-8 production and suppress the gene expression of proinflammatory mediators (TNF-alpha, ICAM-1, VCAM-1, and COX-2) in the TNF-alpha or oxidized low-density lipoprotein (ox-LDL) treated EA.hy926 cells.	Polyphenols	16-27	tumor necrosis factor	Homo sapiens	173-182
31469378-5	2019	After cooking by boiling, a decrease in the total content of polyphenols of about 50%-60% was observed in all pasta samples.	Polyphenols	61-72	solute carrier family 45 member 1	Homo sapiens	110-115
30588893-11	2019	Nevertheless, we observed a significant inverse association between total polyphenol intake and BC risk for postmenopausal women, either for probable or only for confirmed cases (HRT3 v. T1 0 31 (95 % CI 0 13, 0 77; Ptrend=0 010)).	Polyphenols	74-84	hes related family bHLH transcription factor with YRPW motif like	Homo sapiens	179-183
31506575-0	2019	Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition.	Polyphenols	14-24	mitogen-activated protein kinase 8	Homo sapiens	102-105
31531232-0	2019	Polyphenol-rich extract induces apoptosis with immunogenic markers in melanoma cells through the ER stress-associated kinase PERK.	Polyphenols	0-10	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	125-129
31488157-8	2019	We further highlight polyphenols from natural products as AhR agonists or antagonists that regulate AhR activity.	Polyphenols	21-32	aryl hydrocarbon receptor	Homo sapiens	58-61
31488157-8	2019	We further highlight polyphenols from natural products as AhR agonists or antagonists that regulate AhR activity.	Polyphenols	21-32	aryl hydrocarbon receptor	Homo sapiens	100-103
31488157-9	2019	A better understanding of structurally diverse polyphenols and AhR biological activities would allow us to illuminate their molecular mechanism and discover potential therapeutic strategies targeting AhR activation.	Polyphenols	47-58	aryl hydrocarbon receptor	Homo sapiens	200-203
31487863-5	2019	These results were confirmed by invalidating the gene coding for P-gP, which restored the sensitivity of colorectal cells resistant to the polyphenol.	Polyphenols	139-149	phosphoglycolate phosphatase	Homo sapiens	65-69
31469378-9	2019	The results suggest that pasta formulated with legume flours is a low glycaemic food and can be considered a suitable source of polyphenols and flavonoids in human diet.	Polyphenols	128-139	solute carrier family 45 member 1	Homo sapiens	25-30
31750820-0	2019	[Polyphenols from Toona sinensis seeds alleviate neuroinflammation in rats with Parkinson"s disease via inhibiting p38MAPK signaling pathway].	Polyphenols	1-12	mitogen activated protein kinase 14	Rattus norvegicus	115-122
31228500-0	2019	Comparative studies of interaction of beta-lactoglobulin with three polyphenols.	Polyphenols	68-79	beta-lactoglobulin	Bos taurus	38-56
31228500-2	2019	Fluorescence experiments proved that polyphenols strongly quenched the intrinsic fluorescence of beta-LG mainly through static quenching and the main interaction force was hydrophobic interaction.	Polyphenols	37-48	beta-lactoglobulin	Bos taurus	97-104
31228500-3	2019	Moreover, Fourier transform infrared (FTIR) and circular dichroism (CD) indicated that polyphenols changed beta-LG secondary and tertiary structure.	Polyphenols	87-98	beta-lactoglobulin	Bos taurus	107-114
31228500-4	2019	Enzyme-linked immunosorbent assay and molecular modeling study manifested that complex of beta-LG with polyphenols could significantly reduce the IgE-binding capacity of beta-LG due to the polyphenol binding site directly obscures the IgE linear epitopes.	Polyphenols	103-114	beta-lactoglobulin	Bos taurus	90-97
31228500-4	2019	Enzyme-linked immunosorbent assay and molecular modeling study manifested that complex of beta-LG with polyphenols could significantly reduce the IgE-binding capacity of beta-LG due to the polyphenol binding site directly obscures the IgE linear epitopes.	Polyphenols	103-114	beta-lactoglobulin	Bos taurus	170-177
31228500-4	2019	Enzyme-linked immunosorbent assay and molecular modeling study manifested that complex of beta-LG with polyphenols could significantly reduce the IgE-binding capacity of beta-LG due to the polyphenol binding site directly obscures the IgE linear epitopes.	Polyphenols	103-113	beta-lactoglobulin	Bos taurus	90-97
31228500-4	2019	Enzyme-linked immunosorbent assay and molecular modeling study manifested that complex of beta-LG with polyphenols could significantly reduce the IgE-binding capacity of beta-LG due to the polyphenol binding site directly obscures the IgE linear epitopes.	Polyphenols	103-113	beta-lactoglobulin	Bos taurus	170-177
31228500-5	2019	In conclusion, polyphenols had impact on the structure and potential functionality of beta-LG, which would be valuable in dairy processing industry and food nutrition security.	Polyphenols	15-26	beta-lactoglobulin	Bos taurus	86-93
31480575-0	2019	Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice.	Polyphenols	22-32	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	9-12
31375128-3	2019	This positive affective response correlated with the ability of blackcurrant polyphenols to support monoamine neurotransmission via inhibition of monoamine oxidase-B (MAO-B) activity.	Polyphenols	77-88	monoamine oxidase B	Homo sapiens	146-165
31450792-6	2019	The molecular docking results disclosed that beta-lactoglobulin of higher average hydrophobicity had better affinity for the two polyphenols than alpha-lactalbumin of lower average hydrophobicity while beta-lactoglobulin possessed very similar binding sites to the two polyphenols.	Polyphenols	269-280	lactalbumin alpha	Homo sapiens	146-163
31293160-3	2019	The interaction characteristics of these five polyphenols with alpha-amylase and alpha-glucosidase were investigated in terms of the inhibition effect, dynamics, fluorescence quenching, and circular dichroism (CD).	Polyphenols	46-57	sucrase-isomaltase	Homo sapiens	81-98
31293160-5	2019	All five polyphenols inhibited the alpha-amylase activity through the noncompetitive approach but inhibited the alpha-glucosidase activity through the competitive approach.	Polyphenols	9-20	sucrase-isomaltase	Homo sapiens	112-129
30784273-0	2019	Binding of Plant Polyphenols to Serum Albumin and LDL: Healthy Implications for Heart Disease.	Polyphenols	17-28	albumin	Homo sapiens	32-45
30784273-3	2019	Binding with serum albumin and LDL of 41 polyphenols (major antioxidants in plant foods) constituting four classes of flavonoids, three types of phenolic acids, and seven polyphenol conjugate metabolites was investigated indirectly by fluorescence quenching and directly by affinity separation/high-performance liquid chromatography (four of the polyphenols).	Polyphenols	41-52	albumin	Homo sapiens	13-26
30784273-3	2019	Binding with serum albumin and LDL of 41 polyphenols (major antioxidants in plant foods) constituting four classes of flavonoids, three types of phenolic acids, and seven polyphenol conjugate metabolites was investigated indirectly by fluorescence quenching and directly by affinity separation/high-performance liquid chromatography (four of the polyphenols).	Polyphenols	41-51	albumin	Homo sapiens	13-26
30784273-3	2019	Binding with serum albumin and LDL of 41 polyphenols (major antioxidants in plant foods) constituting four classes of flavonoids, three types of phenolic acids, and seven polyphenol conjugate metabolites was investigated indirectly by fluorescence quenching and directly by affinity separation/high-performance liquid chromatography (four of the polyphenols).	Polyphenols	346-357	albumin	Homo sapiens	13-26
31426448-8	2019	The tea polyphenols can protect DA neurons via inhibition of DA oxidation, conjugation with DAQ, scavenge of ROS, inhibition of MAOB, and modulations of Nrf2-Keap1 and PGC-1alpha anti-oxidative signaling pathways.	Polyphenols	8-19	Keap1	Drosophila melanogaster	158-163
31426448-8	2019	The tea polyphenols can protect DA neurons via inhibition of DA oxidation, conjugation with DAQ, scavenge of ROS, inhibition of MAOB, and modulations of Nrf2-Keap1 and PGC-1alpha anti-oxidative signaling pathways.	Polyphenols	8-19	spargel	Drosophila melanogaster	168-178
31375128-3	2019	This positive affective response correlated with the ability of blackcurrant polyphenols to support monoamine neurotransmission via inhibition of monoamine oxidase-B (MAO-B) activity.	Polyphenols	77-88	monoamine oxidase B	Homo sapiens	167-172
31380366-9	2019	Polyphenols also downregulated the expression of adhesive glycoproteins of the Contactin family themselves, demonstrated for both Contactin1 and Contactin2, indicating the involvement of changes in the expression of the underlying genes in the observed phenotype.	Polyphenols	0-11	contactin 1	Homo sapiens	130-140
31370204-1	2019	Some polyphenols have been shown to inhibit, at physiological levels, the VEGF-induced VEGF receptor-2 signaling that causes angiogenesis, allegedly by direct interaction with VEGF and reducing the binding to its receptor VEGFR2.	Polyphenols	5-16	vascular endothelial growth factor A	Homo sapiens	74-78
31370204-1	2019	Some polyphenols have been shown to inhibit, at physiological levels, the VEGF-induced VEGF receptor-2 signaling that causes angiogenesis, allegedly by direct interaction with VEGF and reducing the binding to its receptor VEGFR2.	Polyphenols	5-16	vascular endothelial growth factor A	Homo sapiens	87-91
31370204-1	2019	Some polyphenols have been shown to inhibit, at physiological levels, the VEGF-induced VEGF receptor-2 signaling that causes angiogenesis, allegedly by direct interaction with VEGF and reducing the binding to its receptor VEGFR2.	Polyphenols	5-16	kinase insert domain receptor	Homo sapiens	222-228
31370204-2	2019	Surface plasmon resonance was used to measure the parameters of binding between VEGF and polyphenols as well as the nature of the interactions by assessing the effect of physico-chemical changes in the solution.	Polyphenols	89-100	vascular endothelial growth factor A	Homo sapiens	80-84
31370204-7	2019	Direct interaction and binding between VEGF and polyphenol molecules acting as inhibitors of the signaling of VEGFR2 has been measured for the first time.	Polyphenols	48-58	vascular endothelial growth factor A	Homo sapiens	39-43
31370204-7	2019	Direct interaction and binding between VEGF and polyphenol molecules acting as inhibitors of the signaling of VEGFR2 has been measured for the first time.	Polyphenols	48-58	kinase insert domain receptor	Homo sapiens	110-116
31366075-1	2019	The aim of this study was to estimate the mode of thyroid peroxidase (TPO) inhibition by polyphenols: Chlorogenic acid, rosmarinic acid, quercetin, and rutin.	Polyphenols	89-100	thyroid peroxidase	Homo sapiens	70-73
31366075-2	2019	All the tested polyphenols inhibited TPO; the IC50 values ranged from 0.004 mM to 1.44 mM (for rosmarinic acid and rutin, respectively).	Polyphenols	15-26	thyroid peroxidase	Homo sapiens	37-40
30543828-6	2019	Further, we described the interaction of two naturally occurring polyphenol compounds, naringin and naringenin with mutant SOD1 that is regarded to hinder the protein aggregation.	Polyphenols	65-75	superoxide dismutase 1	Homo sapiens	123-127
31380366-9	2019	Polyphenols also downregulated the expression of adhesive glycoproteins of the Contactin family themselves, demonstrated for both Contactin1 and Contactin2, indicating the involvement of changes in the expression of the underlying genes in the observed phenotype.	Polyphenols	0-11	contactin 2	Homo sapiens	145-155
31276550-1	2019	Despite its poor bioavailability, curcumin is a promising natural polyphenol targeting NF-kappabeta.	Polyphenols	66-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-99
31187838-0	2019	Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation.	Polyphenols	10-21	NLR family, pyrin domain containing 3	Mus musculus	105-110
31184120-0	2019	Correlation Analysis of Intestinal Redox State with the Gut Microbiota Reveals the Positive Intervention of Tea Polyphenols on Hyperlipidemia in High Fat Diet Fed Mice.	Polyphenols	112-123	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	108-111
31184120-1	2019	Tea polyphenols (TP) possess the ability to regulate dyslipidemia and gut microbiota dysbiosis.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
31258902-11	2019	The results of the present study suggest that olive oil polyphenols suppressed the TGF-alpha-induced migration of HCC cells.	Polyphenols	56-67	transforming growth factor alpha	Homo sapiens	83-92
31075724-0	2019	Self-assembled green tea polyphenol-based coordination nanomaterials to improve chemotherapy efficacy by inhibition of carbonyl reductase 1.	Polyphenols	25-35	carbonyl reductase 1	Homo sapiens	119-139
31059841-9	2019	Polyphenols activate intracellular pathways such as arachidonic acid dependent pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway, mitogen-activated protein kinases (MAPKs) pathway, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway and epigenetic modulation, which regulate the host"s immune response.	Polyphenols	0-11	nuclear factor kappa B subunit 1	Homo sapiens	152-161
31059841-9	2019	Polyphenols activate intracellular pathways such as arachidonic acid dependent pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway, mitogen-activated protein kinases (MAPKs) pathway, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway and epigenetic modulation, which regulate the host"s immune response.	Polyphenols	0-11	protein tyrosine kinase 2 beta	Homo sapiens	263-279
31059841-9	2019	Polyphenols activate intracellular pathways such as arachidonic acid dependent pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway, mitogen-activated protein kinases (MAPKs) pathway, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway and epigenetic modulation, which regulate the host"s immune response.	Polyphenols	0-11	AKT serine/threonine kinase 1	Homo sapiens	286-289
31258902-0	2019	Olive oil polyphenols suppress the TGF-alpha-induced migration of hepatocellular carcinoma cells.	Polyphenols	10-21	transforming growth factor alpha	Homo sapiens	35-44
31063765-1	2019	The effect of polyphenols, recognized as the principal antioxidant and beneficial molecules introduced with the diet, extracted from sweet cherry (Prunus avium L.) on the recombinant human mitochondrial carnitine/acylcarnitine transporter (CACT) has been studied in proteoliposomes.	Polyphenols	14-25	solute carrier family 25 member 20	Homo sapiens	203-238
31063765-2	2019	CACT transport activity, which was strongly impaired after oxidation by atmospheric O2 or H2O2, due to the formation of a disulfide bridge between cysteines 136 and 155, was restored by externally added polyphenols.	Polyphenols	203-214	solute carrier family 25 member 20	Homo sapiens	0-4
31063765-3	2019	CACT reduction by polyphenols was time dependent.	Polyphenols	18-29	solute carrier family 25 member 20	Homo sapiens	0-4
30101645-2	2019	Interactions of tea polyphenols with serum albumin may influence the efficacy of drugs.	Polyphenols	20-31	albumin	Homo sapiens	37-50
30157136-1	2019	Tea polyphenols are strong antioxidants, which can be rapidly O-methylated by catechol-O-methyltransferase (COMT).	Polyphenols	4-15	catechol-O-methyltransferase	Homo sapiens	78-106
30157136-1	2019	Tea polyphenols are strong antioxidants, which can be rapidly O-methylated by catechol-O-methyltransferase (COMT).	Polyphenols	4-15	catechol-O-methyltransferase	Homo sapiens	108-112
30157136-10	2019	Green tea drinkers with greater activity of the COMT genotype, whereby polyphenols are effectively excluded, will gain fewer protective benefits against lung cancer development.	Polyphenols	71-82	catechol-O-methyltransferase	Homo sapiens	48-52
31146527-0	2019	Lonicera caerulea Berry Polyphenols Activate SIRT1, Enhancing Inhibition of Raw264.7 Macrophage Foam Cell Formation and Promoting Cholesterol Efflux.	Polyphenols	24-35	sirtuin 1	Mus musculus	45-50
31234523-0	2019	Inhibition of the Self-Assembly of Abeta and of Tau by Polyphenols: Mechanistic Studies.	Polyphenols	55-66	amyloid beta precursor protein	Homo sapiens	35-40
31234523-0	2019	Inhibition of the Self-Assembly of Abeta and of Tau by Polyphenols: Mechanistic Studies.	Polyphenols	55-66	microtubule associated protein tau	Homo sapiens	48-51
31234523-3	2019	In this review, we show that naturally occurring polyphenols abundant in fruits, vegetables, red wine, and tea possess the ability to target pathways associated with the formation of assemblies of Abeta and tau.	Polyphenols	49-60	amyloid beta precursor protein	Homo sapiens	197-202
31234523-3	2019	In this review, we show that naturally occurring polyphenols abundant in fruits, vegetables, red wine, and tea possess the ability to target pathways associated with the formation of assemblies of Abeta and tau.	Polyphenols	49-60	microtubule associated protein tau	Homo sapiens	207-210
31234523-4	2019	Polyphenols modulate the enzymatic processing of the amyloid-beta precursor protein and inhibit toxic Abeta oligomerization by enhancing the clearance of Abeta42 monomer, modulating monomer-monomer interactions and remodeling oligomers to non-toxic forms.	Polyphenols	0-11	amyloid beta precursor protein	Homo sapiens	53-65
31234523-4	2019	Polyphenols modulate the enzymatic processing of the amyloid-beta precursor protein and inhibit toxic Abeta oligomerization by enhancing the clearance of Abeta42 monomer, modulating monomer-monomer interactions and remodeling oligomers to non-toxic forms.	Polyphenols	0-11	amyloid beta precursor protein	Homo sapiens	102-107
31234523-5	2019	Additionally, polyphenols modulate tau hyperphosphorylation and inhibit tau beta-sheet formation.	Polyphenols	14-25	microtubule associated protein tau	Homo sapiens	35-38
31234523-5	2019	Additionally, polyphenols modulate tau hyperphosphorylation and inhibit tau beta-sheet formation.	Polyphenols	14-25	microtubule associated protein tau	Homo sapiens	72-75
31234523-6	2019	The anti-Abeta-self-assembly and anti-tau-self-assembly effects of polyphenols increase their potential as preventive or therapeutic agents against AD, a complex disease that involves many pathological mechanisms.	Polyphenols	67-78	microtubule associated protein tau	Homo sapiens	38-41
31213631-1	2019	A new mechanism is revealed by which a polyphenol, rosmarinic acid (RA), suppresses amyloid beta (Abeta) accumulation in mice.	Polyphenols	39-49	amyloid beta (A4) precursor protein	Mus musculus	98-103
31212946-11	2019	Taken together, our findings show that constituents found in all major tea types, predominantly L-theanine, polyphenols and polyphenol metabolites, are capable of functioning through multiple pathways simultaneously to collectively reduce the risk of depression.	Polyphenols	108-118	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	71-74
31212946-11	2019	Taken together, our findings show that constituents found in all major tea types, predominantly L-theanine, polyphenols and polyphenol metabolites, are capable of functioning through multiple pathways simultaneously to collectively reduce the risk of depression.	Polyphenols	108-119	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	71-74
30722900-0	2019	Mechanism of binding interactions between young apple polyphenols and porcine pancreatic alpha-amylase.	Polyphenols	54-65	probable alpha-amylase 2	Malus domestica	89-102
30722900-1	2019	The binding interactions between young apple polyphenols and porcine pancreatic alpha-amylase were investigated through isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC) and molecular docking.	Polyphenols	45-56	probable alpha-amylase 2	Malus domestica	80-93
30722900-6	2019	These results are consistent with the inhibition of alpha-amylase being caused by the binding of the polyphenols with the enzyme.	Polyphenols	101-112	probable alpha-amylase 2	Malus domestica	52-65
31212848-0	2019	Polyphenol Effects on Splenic Cytokine Response in Post-Weaning Contactin 1-Overexpressing Transgenic Mice.	Polyphenols	0-10	contactin 1	Mus musculus	64-75
31212848-8	2019	In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-gamma, TNF-alpha, IL-6, and IL-4 in homo and hetero mice.	Polyphenols	17-28	interleukin 10	Mus musculus	102-121
31212848-8	2019	In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-gamma, TNF-alpha, IL-6, and IL-4 in homo and hetero mice.	Polyphenols	17-28	interleukin 2	Mus musculus	165-169
31212848-8	2019	In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-gamma, TNF-alpha, IL-6, and IL-4 in homo and hetero mice.	Polyphenols	17-28	interferon gamma	Mus musculus	171-180
31212848-8	2019	In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-gamma, TNF-alpha, IL-6, and IL-4 in homo and hetero mice.	Polyphenols	17-28	tumor necrosis factor	Mus musculus	182-191
31212848-8	2019	In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-gamma, TNF-alpha, IL-6, and IL-4 in homo and hetero mice.	Polyphenols	17-28	interleukin 6	Mus musculus	193-197
31212848-8	2019	In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-gamma, TNF-alpha, IL-6, and IL-4 in homo and hetero mice.	Polyphenols	17-28	interleukin 4	Mus musculus	203-207
31195734-0	2019	Screening of Inhibitory Effects of Polyphenols on Akt-Phosphorylation in Endothelial Cells and Determination of Structure-Activity Features.	Polyphenols	35-46	AKT serine/threonine kinase 1	Homo sapiens	50-53
31312655-0	2019	Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity.	Polyphenols	62-73	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	58-61
31312655-2	2019	Tea polyphenols exert multiple beneficial effects on human health and may play a positive regulatory role in fat assumption.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
31312655-4	2019	Small RNA expression profile can be regulated by tea polyphenols in adipocytes.	Polyphenols	53-64	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	49-52
31312655-5	2019	Therefore, tea polyphenols may regulate fat metabolism by controlling small RNA-associated biological processes.	Polyphenols	15-26	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	11-14
31312655-6	2019	In this study, we developed a systematic research platform based on mouse models and performed small RNA sequencing to identify the specific role of small RNAs in the regulatory effect of tea polyphenols on fat metabolism.	Polyphenols	192-203	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	188-191
31312655-8	2019	Most of these small RNAs participate in lipid metabolism, suggesting that small RNAs play a significant role in tea polyphenol-associated obesity and related pathogenesis.	Polyphenols	116-126	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	112-115
31312655-9	2019	Furthermore, gene ontology and KEGG pathway enrichment indicated that small RNAs influence the regulatory effects of tea polyphenols on obesity, revealing the potential pathogenic mechanisms for such nutritional disease.	Polyphenols	121-132	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	117-120
31195734-4	2019	This work aimed to characterize effects of structurally different polyphenols on Akt-phosphorylation (pAkt) in endothelial cells (Ea.hy926) and to describe structure-activity features.	Polyphenols	66-77	AKT serine/threonine kinase 1	Homo sapiens	81-84
31195734-8	2019	A strong positive and statistically significant correlation between the mean inhibitory effects of the tested polyphenols on both Akt-residues Ser473 and Thr308 (r = 0.9478, p = 0.0003) was determined by immunoblotting.	Polyphenols	110-121	AKT serine/threonine kinase 1	Homo sapiens	130-133
31195734-12	2019	The suggested molecular mode of action of polyphenols involving Akt-inhibition contributes to understanding their effects on the cellular level.	Polyphenols	42-53	AKT serine/threonine kinase 1	Homo sapiens	64-67
30734589-1	2019	This study introduces a simple method for one-step synthesis of highly stable nontoxic polymer-coated gold nanospheres for use in drug delivery, focuses on the ability of chloroauric acid (HAu Cl4 ) to induce polyphenols polymerization, puts up an easy procedure for loading hydrophobic drugs onto gold nanoparticles with ultra-high loading efficiency and studies the cytotoxicity of free and gold nanoparticles-loaded resveratrol.	Polyphenols	209-220	endogenous retrovirus group W member 3	Homo sapiens	193-196
31154600-0	2019	Design, synthesis, and biological evaluation of polyphenols with 4,6-diphenylpyrimidin-2-amine derivatives for inhibition of Aurora kinase A.	Polyphenols	48-59	aurora kinase A	Homo sapiens	125-140
31281594-8	2019	Polyphenols tend to fine-tune SIRT1 expression towards normal in the liver of intoxicated rats in both acute and subchronic studies.	Polyphenols	0-11	sirtuin 1	Rattus norvegicus	30-35
31281594-10	2019	The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols.	Polyphenols	80-91	sirtuin 1	Rattus norvegicus	26-31
31281594-10	2019	The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols.	Polyphenols	80-91	sirtuin 1	Rattus norvegicus	98-103
31281594-10	2019	The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols.	Polyphenols	80-91	sirtuin 1	Rattus norvegicus	98-103
31281594-10	2019	The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols.	Polyphenols	195-206	sirtuin 1	Rattus norvegicus	26-31
31089945-0	2019	Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt-p53-p21 pathways.	Polyphenols	12-23	microRNA 126	Homo sapiens	109-116
30935952-1	2019	Catechol-containing polyphenols present in coffee and tea, while serving as excellent substrates for catechol-O-methyltransferase (COMT)-catalyzed O-methylation, can also operate as COMT inhibitors.	Polyphenols	20-31	catechol-O-methyltransferase	Homo sapiens	131-135
30935952-1	2019	Catechol-containing polyphenols present in coffee and tea, while serving as excellent substrates for catechol-O-methyltransferase (COMT)-catalyzed O-methylation, can also operate as COMT inhibitors.	Polyphenols	20-31	catechol-O-methyltransferase	Homo sapiens	182-186
31089945-0	2019	Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt-p53-p21 pathways.	Polyphenols	12-23	AKT serine/threonine kinase 1	Homo sapiens	117-120
31089945-0	2019	Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt-p53-p21 pathways.	Polyphenols	12-23	tumor protein p53	Homo sapiens	121-124
31089945-0	2019	Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt-p53-p21 pathways.	Polyphenols	12-23	H3 histone pseudogene 16	Homo sapiens	125-128
31093947-2	2019	Recently, several polyphenols have been considered as the effective therapeutic approaches that appear to influence SIRT1.	Polyphenols	18-29	sirtuin 1	Homo sapiens	116-121
31108962-5	2019	Polyphenols can scavenge reactive oxygen and nitrogen species and activate redox-responsible transcription factors to regulate expression of genes, coding antioxidants, anti-apoptotic Bcl-2 protein family, and pro-survival neurotrophic factors.	Polyphenols	0-11	BCL2 apoptosis regulator	Homo sapiens	184-189
31257800-11	2019	Compared with the MCT group, the apple polyphenol treatment could improve the above mentioned situation, and the COX-2 and Ca2+ indicators of the apple polyphenol treatment group were decreased significantly (P&lt;0.05).	Polyphenols	152-162	cytochrome c oxidase subunit II	Malus domestica	113-118
31004130-1	2019	The aim of this study was to determine the effects of dietary grape seed polyphenols (GSP) supplementation during the late gestation and lactation period on reproductive performance, antioxidative status in serum, nutrient composition, and Ig content in colostrum of multiparous sows.	Polyphenols	73-84	GSM1	Homo sapiens	86-89
31191562-6	2019	Through non-catalytic, so-called ligandin properties, numerous plant GSTs also participate in the binding and transport of small heterocyclic ligands such as flavonoids including anthocyanins, and polyphenols.	Polyphenols	197-208	hematopoietic prostaglandin D synthase	Homo sapiens	69-73
31013659-7	2019	The main RA factors modified by polyphenols are mitogen-activated protein kinase (MAPK), interleukin-1beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) and c-Jun N-terminal kinases (JNK).	Polyphenols	32-43	nuclear factor kappa B subunit 1	Homo sapiens	230-239
30642485-3	2019	Extracts from polyphenol-protein particles significantly decreased reactive oxygen species (ROS) production and down-regulated the gene expression of inflammation markers (COX-2 and IL-1beta).	Polyphenols	14-24	cox2	Triticum aestivum	172-177
31134076-7	2019	Further, some polyphenols can suppress overexpression of inflammatory mediators through TLR4/NF-kappaB/STAT signaling intervention, while others can reduce neuronal apoptosis via modulating the TLR4/MyD88/NF-kappaB-pathway in microglia/macrophages.	Polyphenols	14-25	toll like receptor 4	Homo sapiens	88-92
31134076-7	2019	Further, some polyphenols can suppress overexpression of inflammatory mediators through TLR4/NF-kappaB/STAT signaling intervention, while others can reduce neuronal apoptosis via modulating the TLR4/MyD88/NF-kappaB-pathway in microglia/macrophages.	Polyphenols	14-25	nuclear factor kappa B subunit 1	Homo sapiens	93-102
31134076-7	2019	Further, some polyphenols can suppress overexpression of inflammatory mediators through TLR4/NF-kappaB/STAT signaling intervention, while others can reduce neuronal apoptosis via modulating the TLR4/MyD88/NF-kappaB-pathway in microglia/macrophages.	Polyphenols	14-25	toll like receptor 4	Homo sapiens	194-198
31134076-7	2019	Further, some polyphenols can suppress overexpression of inflammatory mediators through TLR4/NF-kappaB/STAT signaling intervention, while others can reduce neuronal apoptosis via modulating the TLR4/MyD88/NF-kappaB-pathway in microglia/macrophages.	Polyphenols	14-25	MYD88 innate immune signal transduction adaptor	Homo sapiens	199-204
31134076-7	2019	Further, some polyphenols can suppress overexpression of inflammatory mediators through TLR4/NF-kappaB/STAT signaling intervention, while others can reduce neuronal apoptosis via modulating the TLR4/MyD88/NF-kappaB-pathway in microglia/macrophages.	Polyphenols	14-25	nuclear factor kappa B subunit 1	Homo sapiens	205-214
31027340-2	2019	Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies.	Polyphenols	10-21	insulin	Homo sapiens	80-87
30249814-5	2019	These polyphenols were docked to several targets, including APP, BACE, PSEN, IDE, CASP, calpain and TNF-alpha, suggesting potential in vivo activities.	Polyphenols	6-17	beta-site APP cleaving enzyme 1	Mus musculus	65-69
30249814-5	2019	These polyphenols were docked to several targets, including APP, BACE, PSEN, IDE, CASP, calpain and TNF-alpha, suggesting potential in vivo activities.	Polyphenols	6-17	insulin degrading enzyme	Mus musculus	77-80
30249814-5	2019	These polyphenols were docked to several targets, including APP, BACE, PSEN, IDE, CASP, calpain and TNF-alpha, suggesting potential in vivo activities.	Polyphenols	6-17	cartilage associated protein	Mus musculus	82-86
30249814-5	2019	These polyphenols were docked to several targets, including APP, BACE, PSEN, IDE, CASP, calpain and TNF-alpha, suggesting potential in vivo activities.	Polyphenols	6-17	tumor necrosis factor	Mus musculus	100-109
31002738-0	2019	Retraction: Resveratrol and Black Tea Polyphenol Combination Synergistically Suppress Mouse Skin Tumors Growth by Inhibition of Activated MAPKs and p53.	Polyphenols	38-48	transformation related protein 53, pseudogene	Mus musculus	148-151
31139371-1	2019	jam as a polyphenol-enriched functional food ingredient.	Polyphenols	9-19	F11 receptor	Homo sapiens	0-3
30900716-6	2019	Compared with green tea, significantly decreased levels of water extract, tea polyphenol and amino acid were found in dark tea, whereas the content of both caffeine and gallocatechin was increased.	Polyphenols	78-88	dark	Mus musculus	118-122
30892883-3	2019	Certain polyphenol compounds, such as flavonoids, have shown a potent capacity to inhibit VEGF and, consequently, angiogenesis.	Polyphenols	8-18	vascular endothelial growth factor A	Homo sapiens	90-94
30771602-2	2019	Accordingly, we screened a library of polyphenols and synthetic derivatives thereof for their capacity to inhibit tau-aggregation using a thioflavin T-based fluorescence method.	Polyphenols	38-49	microtubule associated protein tau	Homo sapiens	114-117
30871261-0	2019	Protective Effects of Kuding Tea (Ilex kudingcha C. J. Tseng) Polyphenols on UVB-Induced Skin Aging in SKH1 Hairless Mice.	Polyphenols	62-73	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	29-32
30935135-1	2019	Some polyphenols, which are common natural compounds in fruits, vegetables, seeds, and oils, have been considered as potent inhibitors of amyloid beta (Abeta) aggregation, one critical pathogenic event in Alzheimer"s disease (AD).	Polyphenols	5-16	amyloid beta precursor protein	Homo sapiens	152-157
30948927-2	2019	Morin is a natural polyphenol which negatively modulates, among others, the activity of LMW-PTP, leading to the potentiation of the effects of different antitumoral drugs, representing a potential beneficial treatment against cancer.	Polyphenols	19-29	acid phosphatase 1, soluble	Mus musculus	88-95
30530068-8	2019	The apparent activation energy of the complexation reaction was evaluated to be 289.29 J mol-1 which is consistent with the chemistry of Fe(III) with polyphenols which are supposed to mimic the interaction of Fe(III) with transferrin in biological media.	Polyphenols	150-161	transferrin	Homo sapiens	222-233
30875717-0	2019	The Effect of Green and Black Tea Polyphenols on BRCA2 Deficient Chinese Hamster Cells by Synthetic Lethality through PARP Inhibition.	Polyphenols	34-45	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	49-54
30875717-0	2019	The Effect of Green and Black Tea Polyphenols on BRCA2 Deficient Chinese Hamster Cells by Synthetic Lethality through PARP Inhibition.	Polyphenols	34-45	poly [ADP-ribose] polymerase 1	Cricetulus griseus	118-122
30875717-3	2019	The observed cytotoxicity of these polyphenols to BRCA2 deficient cells is believed to be a result of PARP inhibition induced synthetic lethality.	Polyphenols	35-46	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	50-55
30875717-3	2019	The observed cytotoxicity of these polyphenols to BRCA2 deficient cells is believed to be a result of PARP inhibition induced synthetic lethality.	Polyphenols	35-46	poly [ADP-ribose] polymerase 1	Cricetulus griseus	102-106
30875717-11	2019	Polyphenol treatment induced more micronuclei formation in BRCA2 deficient cells and rad51D deficient cells when compared against the respective wild type cells.	Polyphenols	0-10	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	59-64
30875717-11	2019	Polyphenol treatment induced more micronuclei formation in BRCA2 deficient cells and rad51D deficient cells when compared against the respective wild type cells.	Polyphenols	0-10	DNA repair protein RAD51 homolog 4	Cricetulus griseus	85-91
30875717-12	2019	In conclusion, tea polyphenols, epigallocatechin gallate, and theaflavin may present selective cytotoxicity to BRCA2 deficient cells through synthetic lethality induced by PARP inhibition.	Polyphenols	19-30	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	111-116
30875717-12	2019	In conclusion, tea polyphenols, epigallocatechin gallate, and theaflavin may present selective cytotoxicity to BRCA2 deficient cells through synthetic lethality induced by PARP inhibition.	Polyphenols	19-30	poly [ADP-ribose] polymerase 1	Cricetulus griseus	172-176
30703746-0	2019	CSRP3 mediates polyphenols-induced cardioprotection in hypertension.	Polyphenols	15-26	cysteine and glycine rich protein 3	Rattus norvegicus	0-5
30703746-8	2019	In neonatal rat ventricular cardiomyocytes, CSRP3 was validated as a target of a berries-derived polyphenol metabolite, 4-methylcatechol sulfate, at micromolar concentrations, mimicking physiological conditions of human plasma circulation.	Polyphenols	97-107	cysteine and glycine rich protein 3	Rattus norvegicus	44-49
30703746-10	2019	Our systemic study clearly supports the modulation of CSRP3 by a polyphenol-rich berries diet as an efficient cardioprotective strategy in hypertension-induced heart failure.	Polyphenols	65-75	cysteine and glycine rich protein 3	Homo sapiens	54-59
30785017-3	2019	Some plant-derived polyphenols are known to protect skin fibroblasts against UV through induction of Nrf2-dependent antioxidant genes expression.	Polyphenols	19-30	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
30877853-7	2019	Moreover, pharmacologic molecules including nicotinamide and EX-527 attenuate SirT1 activity; purported activators of SirT1, the polyphenol S17834, the polyphenol resveratrol, or the non-polyphenolic Sirtris compound SRT1720, failed to activate endogenous SirT1 significantly.	Polyphenols	129-139	sirtuin 1	Mus musculus	78-83
30794412-6	2019	These findings suggest that curcumin, despite low systemic bioavailability, may be enzymatically activated (deconjugated) within GUSB-enriched bone to exert protective effects, a metabolic process that could also contribute to bone-protective effects of other highly glucuronidated dietary polyphenols.	Polyphenols	290-301	glucuronidase, beta	Mus musculus	129-133
30529349-5	2019	The greatest incorporation of polyphenol into the BCh-S-GA5.0 films greatly reduced WVP and swelling values in approximately 61.01% and 23%, respectively also the tensile strength value increased to 37.372 MPa.	Polyphenols	30-40	chimerin 2	Homo sapiens	50-53
30802511-10	2019	Based on the shift in the omega-6/omega-3 balance towards omega-6, as well as the increase in COX-2 and TNFalpha protein expressions, we may postulate a pro-inflammatory nature of the examined polyphenol.	Polyphenols	193-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
30802511-10	2019	Based on the shift in the omega-6/omega-3 balance towards omega-6, as well as the increase in COX-2 and TNFalpha protein expressions, we may postulate a pro-inflammatory nature of the examined polyphenol.	Polyphenols	193-203	tumor necrosis factor	Homo sapiens	104-112
30875793-0	2019	Liver Injury Induced by Carbon Tetrachloride in Mice Is Prevented by the Antioxidant Capacity of Anji White Tea Polyphenols.	Polyphenols	112-123	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	108-111
30875793-1	2019	Anji white tea is a unique variety of green tea that is rich in polyphenols.	Polyphenols	64-75	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	11-14
30875793-1	2019	Anji white tea is a unique variety of green tea that is rich in polyphenols.	Polyphenols	64-75	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	44-47
30875793-2	2019	In this study, the effect of Anji white tea polyphenols (AJWTP) on the prevention of carbon tetrachloride (CCl4)-induced liver injury through its antioxidant properties was studied.	Polyphenols	44-55	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	40-43
30871261-2	2019	The ion precipitation method was used for extraction of polyphenols from Kuding tea.	Polyphenols	56-67	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	80-83
30537158-0	2019	Structural analysis of the inhibitory effects of polyphenols, (+)-hopeaphenol and (-)-isohopeaphenol, on human SIRT1.	Polyphenols	49-60	sirtuin 1	Homo sapiens	111-116
30832407-4	2019	All polyphenols, except cyanidin, inhibited the effects on FAS and PPARgamma and further increased CPT1A1 expression, suggesting a shift toward increased beta-oxidation.	Polyphenols	4-15	peroxisome proliferator activated receptor gamma	Homo sapiens	67-76
30779137-10	2019	Ten polyphenol compounds were identified in PF-A and PF-B, respectively, by HPLC-MS/MS, including quercetin, apigenin, myricetin, and so on.	Polyphenols	4-14	keratin 75	Homo sapiens	53-57
30881359-0	2019	Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1.	Polyphenols	14-25	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	91-95
30881359-0	2019	Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1.	Polyphenols	14-25	heme oxygenase 1	Homo sapiens	119-135
30881359-6	2019	The regulation of DC metabolism by these polyphenols appeared to be mediated by their activation of the cellular energy sensor, AMP-activated Protein Kinase (AMPK), which resulted in the inhibition of mTOR signaling in LPS-stimulated DC.	Polyphenols	41-52	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	128-156
30881359-6	2019	The regulation of DC metabolism by these polyphenols appeared to be mediated by their activation of the cellular energy sensor, AMP-activated Protein Kinase (AMPK), which resulted in the inhibition of mTOR signaling in LPS-stimulated DC.	Polyphenols	41-52	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	158-162
30881359-6	2019	The regulation of DC metabolism by these polyphenols appeared to be mediated by their activation of the cellular energy sensor, AMP-activated Protein Kinase (AMPK), which resulted in the inhibition of mTOR signaling in LPS-stimulated DC.	Polyphenols	41-52	mechanistic target of rapamycin kinase	Homo sapiens	201-205
30881359-8	2019	Here we also demonstrate that the induction of HO-1 by polyphenols in human DC is dependent on their activation of AMPK.	Polyphenols	55-66	heme oxygenase 1	Homo sapiens	47-51
30881359-8	2019	Here we also demonstrate that the induction of HO-1 by polyphenols in human DC is dependent on their activation of AMPK.	Polyphenols	55-66	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	115-119
30506347-0	2019	Untargeted Metabolomics Analytical Strategy Based on Liquid Chromatography/Electrospray Ionization Linear Ion Trap Quadrupole/Orbitrap Mass Spectrometry for Discovering New Polyphenol Metabolites in Human Biofluids after Acute Ingestion of Vaccinium myrtillus Berry Supplement.	Polyphenols	173-183	TRAP	Homo sapiens	110-114
30506347-1	2019	In this work, liquid chromatography, coupled with an electrospray ionization hybrid linear ion trap quadrupole/Orbitrap mass spectrometry, has been used to accurately identify polyphenol metabolites in human serum and urine after acute ingestion of a V. myrtillus berry supplement.	Polyphenols	176-186	TRAP	Homo sapiens	95-99
30637573-1	2019	Cinnamon polyphenol extract (CPE) improves people with insulin resistance.	Polyphenols	9-19	insulin	Homo sapiens	55-62
30867802-13	2019	Additionally, a natural polyphenol resveratrol in combination with forskolin elevated the concentration of cAMP and enhanced the expression of Myc and the malignant phenotype of DLD-1 cells, reproducing the effect of known chemical inhibitors of PDE4.	Polyphenols	24-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	143-146
30867802-13	2019	Additionally, a natural polyphenol resveratrol in combination with forskolin elevated the concentration of cAMP and enhanced the expression of Myc and the malignant phenotype of DLD-1 cells, reproducing the effect of known chemical inhibitors of PDE4.	Polyphenols	24-34	phosphodiesterase 4A	Homo sapiens	246-250
30552915-7	2019	These results reveal a novel molecular mechanism by which resveratrol induces apoptosis in prostate cancer cells, and highlight the importance of DUSP1 in future therapeutic approaches based in the use of this polyphenol and cisplatin.	Polyphenols	210-220	dual specificity phosphatase 1	Homo sapiens	146-151
30813510-1	2019	Cocoa bean is a rich source of polyphenols, mainly flavonoids which have a wide range of biological properties.	Polyphenols	31-42	brain expressed, associated with NEDD4, 1	Rattus norvegicus	6-10
30418193-3	2019	In this study, our aim was to manipulate TRAIL-apoptosis pathway by hydroxychavicol (HCH), a polyphenol from Piper betel leaf, for the induction of apoptosis in TRAIL resistant chronic myeloid leukemia cell.	Polyphenols	93-103	TNF superfamily member 10	Homo sapiens	41-46
30418193-3	2019	In this study, our aim was to manipulate TRAIL-apoptosis pathway by hydroxychavicol (HCH), a polyphenol from Piper betel leaf, for the induction of apoptosis in TRAIL resistant chronic myeloid leukemia cell.	Polyphenols	93-103	TNF superfamily member 10	Homo sapiens	161-166
29274033-0	2019	Supplementation with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1alpha pathway.	Polyphenols	95-106	NAD-dependent protein deacetylase sirtuin-1	Oryctolagus cuniculus	148-153
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	Polyphenols	19-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
31353662-0	2019	Protective effects of hawthorn (Crataegus pinnatifida) polyphenol extract against UVB-induced skin damage by modulating the p53 mitochondrial pathway in vitro and in vivo.	Polyphenols	55-65	tumor protein p53	Homo sapiens	124-127
30594360-0	2019	Tea polyphenols protect bovine mammary epithelial cells from hydrogen peroxide-induced oxidative damage in vitro by activating NFE2L2/HMOX1 pathways.	Polyphenols	4-15	NFE2 like bZIP transcription factor 2	Bos taurus	127-133
30594360-0	2019	Tea polyphenols protect bovine mammary epithelial cells from hydrogen peroxide-induced oxidative damage in vitro by activating NFE2L2/HMOX1 pathways.	Polyphenols	4-15	heme oxygenase 1	Bos taurus	134-139
31353662-6	2019	Treatment with HPE or its polyphenol components inhibited the UVB-induced damage by removing an excess of reactive oxygen species (ROS), reducing DNA damage and p53 activation, regulating the protein expression of B-cell lymphoma 2 family members toward antiapoptotic ratios, and reducing caspase activation.	Polyphenols	26-36	tumor protein p53	Homo sapiens	161-164
30847127-6	2019	The results showed that each polyphenol compound induces different expression patterns of the mucin genes.	Polyphenols	29-39	LOC100508689	Homo sapiens	94-99
30443985-0	2019	Polyphenols and Tryptophan Metabolites Activate the Aryl Hydrocarbon Receptor in an in vitro Model of Colonic Fermentation.	Polyphenols	0-11	aryl hydrocarbon receptor	Homo sapiens	52-77
30394624-0	2019	Suppression, disaggregation, and modulation of gamma-Synuclein fibrillation pathway by green tea polyphenol EGCG.	Polyphenols	97-107	synuclein gamma	Homo sapiens	47-62
30530257-0	2019	Heterogeneity in gut microbiota drive polyphenol metabolism that influences alpha-synuclein misfolding and toxicity.	Polyphenols	38-48	synuclein, alpha	Mus musculus	76-91
31223050-1	2019	Epigallocatechin gallate (EGCG) is a major polyphenols of green tea may have the possibility to inhibit epidermal growth factor receptor (EGFR) activity and lead to reduce non-small cell lung cancer (NSCLC) progression.	Polyphenols	43-54	epidermal growth factor receptor	Homo sapiens	104-136
31223050-1	2019	Epigallocatechin gallate (EGCG) is a major polyphenols of green tea may have the possibility to inhibit epidermal growth factor receptor (EGFR) activity and lead to reduce non-small cell lung cancer (NSCLC) progression.	Polyphenols	43-54	epidermal growth factor receptor	Homo sapiens	138-142
30368304-0	2019	Fast and direct amperometric analysis of polyphenols in beers using tyrosinase-modified screen-printed gold nanoparticles biosensors.	Polyphenols	41-52	tyrosinase	Homo sapiens	68-78
30525561-1	2019	Resveratrol is a polyphenol commonly found in plants and food health products, such as grape and red wine, and was identified for its binding to vascular endothelial growth factor (VEGF) by using HerboChips screening.	Polyphenols	17-27	vascular endothelial growth factor A	Homo sapiens	181-185
30847127-9	2019	The polyphenols considered in this study may influence mucin secretion and act on diverse salivary substrates to change the barrier properties of mucins for mucus secretion in different ways.	Polyphenols	4-15	LOC100508689	Homo sapiens	55-60
30554657-4	2019	Surprisingly, resveratrol, a polyphenol, led to not only down-regulation of TRIML2 but also cell-cycle arrest at G1 phase similar to TRIML2 knockdown experiments.	Polyphenols	29-39	tripartite motif family like 2	Homo sapiens	76-82
30629444-2	2019	This has led to an increased research interest in Tyr inhibitors during the last decades, with a frequent focus on polyphenols.	Polyphenols	115-126	tyrosinase	Homo sapiens	50-53
30629444-4	2019	Since some polyphenols are accepted as substrates by mh-Tyr, the present study aimed to more generally investigate this enzyme"s specificity toward polyphenols and to discuss its significance in the context of bioactivity-guided fractionation.	Polyphenols	11-22	tyrosinase	Homo sapiens	56-59
30629444-4	2019	Since some polyphenols are accepted as substrates by mh-Tyr, the present study aimed to more generally investigate this enzyme"s specificity toward polyphenols and to discuss its significance in the context of bioactivity-guided fractionation.	Polyphenols	148-159	tyrosinase	Homo sapiens	56-59
31187713-3	2019	However, the gp120-CD4 binding inhibitory activity of polyphenols has not been analysed in silico yet.	Polyphenols	54-65	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	13-18
30626086-0	2019	Bamboo Stems (Phyllostachys nigra variety henosis) Containing Polyphenol Mixtures Activate Nrf2 and Attenuate Phenylhydrazine-Induced Oxidative Stress and Liver Injury.	Polyphenols	62-72	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
30626086-2	2019	Ethyl acetate fraction of 80% ethanol extract of Phyllostachys nigra stem (PN3) containing polyphenols had a higher NQO1-ARE reporter gene activity as monitored by the activity of the NF-E2-related factor (Nrf2) antioxidant pathway in cells in comparison to extracts from other species and under other conditions.	Polyphenols	91-102	sodium voltage-gated channel alpha subunit 10	Homo sapiens	75-78
30626086-2	2019	Ethyl acetate fraction of 80% ethanol extract of Phyllostachys nigra stem (PN3) containing polyphenols had a higher NQO1-ARE reporter gene activity as monitored by the activity of the NF-E2-related factor (Nrf2) antioxidant pathway in cells in comparison to extracts from other species and under other conditions.	Polyphenols	91-102	NFE2 like bZIP transcription factor 2	Homo sapiens	206-210
30626086-6	2019	Treatment with major polyphenols of PN3, including catechin, chlorogenic acid, caffeic acid, and p-coumaric acid, also improved AA + iron-mediated oxidative stress and, thus, improved cell viability.	Polyphenols	21-32	sodium voltage-gated channel alpha subunit 10	Homo sapiens	36-39
30606217-0	2019	Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model.	Polyphenols	25-35	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	21-24
30384152-1	2019	OBJECTIVES: To study the effects of polyphenol resveratrol on TNFalpha-induced inflammatory signaling as well as the underlying mechanism in human dental pulp stem cells (DPSCs).	Polyphenols	36-46	tumor necrosis factor	Homo sapiens	62-70
30257140-3	2019	Recently, we found that resveratrol, a polyphenol compound, increased the expression of Cx26 and Cx43, which are connexins and important constituents of gap junctions, in murine hepatoma cells.	Polyphenols	39-49	gap junction protein, beta 2	Mus musculus	88-92
30257140-3	2019	Recently, we found that resveratrol, a polyphenol compound, increased the expression of Cx26 and Cx43, which are connexins and important constituents of gap junctions, in murine hepatoma cells.	Polyphenols	39-49	gap junction protein, alpha 1	Mus musculus	97-101
30528730-7	2019	A natural polyphenol resveratrol that was reported to have PDE4 inhibitory effects also showed tumor suppressive effects by inhibiting the mTOR-Myc axis.	Polyphenols	10-20	phosphodiesterase 4A	Homo sapiens	59-63
30528730-7	2019	A natural polyphenol resveratrol that was reported to have PDE4 inhibitory effects also showed tumor suppressive effects by inhibiting the mTOR-Myc axis.	Polyphenols	10-20	mechanistic target of rapamycin kinase	Homo sapiens	139-143
30528730-7	2019	A natural polyphenol resveratrol that was reported to have PDE4 inhibitory effects also showed tumor suppressive effects by inhibiting the mTOR-Myc axis.	Polyphenols	10-20	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	144-147
30634721-3	2019	In this paper, a previously optimized method based on reversed phase high performance liquid chromatography (HPLC) with ultraviolet/visible (UV/Vis) detection has been applied to determine polyphenols in cava wines.	Polyphenols	189-200	carbonic anhydrase 5A	Homo sapiens	204-208
31838869-7	2019	Western blot analysis revealed that NLE and NLPE (polyphenol-rich NLE) repressed ER-alpha expression and phosphorylation and decreased the phosphorylation of Her-2 without affecting their expression.	Polyphenols	50-60	estrogen receptor 1 (alpha)	Mus musculus	81-89
30396086-0	2019	Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3beta activity, oxidative stress and pro-inflammatory cytokines.	Polyphenols	0-10	glycogen synthase kinase 3 beta	Rattus norvegicus	130-138
30351529-9	2019	S. lentiscifolius bark extract has antioxidant activity and inhibitory effect on HSR probably due to the presence of polyphenols as the flavonoids quercetin and kaempferol.	Polyphenols	117-128	HSR	Homo sapiens	81-84
29993262-3	2019	Polyphenols from coffee, guava tea, whortleberry, olive oil, propolis, chocolate, red wine, grape seed, and cocoa have been reported to show anti-diabetic effects in T2D patients through increasing glucose metabolism, improving vascular function as well as reducing insulin resistance and HbA1c level.	Polyphenols	0-11	insulin	Homo sapiens	266-273
30592255-9	2019	The few clinical trials investigating the influence of nutritional, lifestyle and drugs on PON1 activities in the general population suggest that some polyphenols, oleic acid, Mediterranean diet, no smoking, being physically active and statins may be effective strategies that increase PON1 activity.	Polyphenols	151-162	paraoxonase 1	Homo sapiens	286-290
31187713-3	2019	However, the gp120-CD4 binding inhibitory activity of polyphenols has not been analysed in silico yet.	Polyphenols	54-65	CD4 molecule	Homo sapiens	19-22
30572687-1	2018	Theaflavins, the characteristic and bioactive polyphenols in black tea, possess the potential improving effects on insulin resistance-associated metabolic abnormalities, including obesity and type 2 diabetes mellitus.	Polyphenols	46-57	insulin	Homo sapiens	115-122
30661406-0	2019	An Olive Leaf Extract Rich in Polyphenols Promotes Apoptosis in Cervical Cancer Cells by Upregulating p21Cip/WAF1 Gene Expression.	Polyphenols	30-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	109-113
30857437-4	2019	Dose-dependent significant increase in PBP-mediated over-expression and activity of GSTs (alpha in the liver while pi in the lung) were observed in polyphenol-treated groups.	Polyphenols	148-158	phosphatidylethanolamine binding protein 1	Mus musculus	39-42
30585182-0	2018	Assessment of the Polyphenol Indices and Antioxidant Capacity for Beers and Wines Using a Tyrosinase-Based Biosensor Prepared by Sinusoidal Current Method.	Polyphenols	18-28	tyrosinase	Homo sapiens	90-100
30572579-7	2018	The positions of the PUFA on the polyphenol core appear to influence the antioxidant effect.	Polyphenols	33-43	pumilio RNA binding family member 3	Homo sapiens	21-25
30518397-0	2018	The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma.	Polyphenols	12-22	signal transducer and activator of transcription 3	Mus musculus	65-70
30383966-3	2018	Here, an adenosine triphosphate (ATP)-responsive autocatalytic Fenton nanosystem (GOx@ZIF@MPN), incorporated with glucose oxidase (GOx) in zeolitic imidazolate framework (ZIF) and then coated with metal polyphenol network (MPN), was designed and synthesized for tumor ablation with self-supplied H2O2 and TA-mediated acceleration of Fe(III)/Fe(II) conversion.	Polyphenols	203-213	hydroxyacid oxidase 1	Homo sapiens	82-85
30383966-3	2018	Here, an adenosine triphosphate (ATP)-responsive autocatalytic Fenton nanosystem (GOx@ZIF@MPN), incorporated with glucose oxidase (GOx) in zeolitic imidazolate framework (ZIF) and then coated with metal polyphenol network (MPN), was designed and synthesized for tumor ablation with self-supplied H2O2 and TA-mediated acceleration of Fe(III)/Fe(II) conversion.	Polyphenols	203-213	hydroxyacid oxidase 1	Homo sapiens	114-129
30383966-3	2018	Here, an adenosine triphosphate (ATP)-responsive autocatalytic Fenton nanosystem (GOx@ZIF@MPN), incorporated with glucose oxidase (GOx) in zeolitic imidazolate framework (ZIF) and then coated with metal polyphenol network (MPN), was designed and synthesized for tumor ablation with self-supplied H2O2 and TA-mediated acceleration of Fe(III)/Fe(II) conversion.	Polyphenols	203-213	hydroxyacid oxidase 1	Homo sapiens	131-134
30544666-0	2018	Novel Clofarabine-Based Combinations with Polyphenols Epigenetically Reactivate Retinoic Acid Receptor Beta, Inhibit Cell Growth, and Induce Apoptosis of Breast Cancer Cells.	Polyphenols	42-53	retinoic acid receptor beta	Homo sapiens	80-107
30371539-0	2018	Green tea polyphenols ameliorate ethanol-induced spatial learning and memory impairments by enhancing hippocampus NMDAR1 expression and CREB activity in rats.	Polyphenols	10-21	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	114-120
30371539-0	2018	Green tea polyphenols ameliorate ethanol-induced spatial learning and memory impairments by enhancing hippocampus NMDAR1 expression and CREB activity in rats.	Polyphenols	10-21	cAMP responsive element binding protein 1	Rattus norvegicus	136-140
30411897-7	2018	Improved inhibitory effects of polyphenol mixture on cell death and senescence-associated beta-galactosidase expression were also observed.	Polyphenols	31-41	galactosidase beta 1	Homo sapiens	90-108
30518397-11	2018	RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells.	Polyphenols	21-31	signal transducer and activator of transcription 3	Mus musculus	51-56
30518397-11	2018	RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells.	Polyphenols	21-31	signal transducer and activator of transcription 3	Mus musculus	93-98
30717558-0	2018	[Tea polyphenols delays human glomerular mesangial cells senescence induced by high glucose via regulating STAT3/miR-126/telomere signaling pathway activation].	Polyphenols	5-16	signal transducer and activator of transcription 3	Homo sapiens	107-112
30316844-0	2018	Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes.	Polyphenols	4-15	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	23-28
30182373-7	2018	Meanwhile, epigallocatechin-3-gallate (EGCG), a green tea polyphenol which has been identified as an effective anticancer compound was able to increase miR-485 expression dose-dependently in A549/CDDP cells.	Polyphenols	58-68	microRNA 485	Homo sapiens	152-159
30510092-0	2018	Editor"s Note: Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems.	Polyphenols	72-83	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	68-71
28988315-0	2018	Serum gamma-glutamyltransferase is inversely associated with dietary total and coffee-derived polyphenol intakes in apparently healthy Japanese men.	Polyphenols	94-104	gamma-glutamyltransferase light chain family member 3	Homo sapiens	6-31
28988315-2	2018	Here, we examined the association between serum GGT and the dietary intake of polyphenols, which have antioxidant properties.	Polyphenols	78-89	gamma-glutamyltransferase light chain family member 3	Homo sapiens	48-51
28988315-7	2018	The analysis of the association between polyphenol intake and biological parameters showed a significant negative association between polyphenol intake and the levels of systolic and diastolic blood pressure (SBP and DBP), GGT, and alanine aminotransferase (ALT) after adjusting for age, smoking habit, energy intake and alcohol intake.	Polyphenols	40-50	selenium binding protein 1	Homo sapiens	209-212
28988315-7	2018	The analysis of the association between polyphenol intake and biological parameters showed a significant negative association between polyphenol intake and the levels of systolic and diastolic blood pressure (SBP and DBP), GGT, and alanine aminotransferase (ALT) after adjusting for age, smoking habit, energy intake and alcohol intake.	Polyphenols	134-144	selenium binding protein 1	Homo sapiens	209-212
28988315-7	2018	The analysis of the association between polyphenol intake and biological parameters showed a significant negative association between polyphenol intake and the levels of systolic and diastolic blood pressure (SBP and DBP), GGT, and alanine aminotransferase (ALT) after adjusting for age, smoking habit, energy intake and alcohol intake.	Polyphenols	134-144	D-box binding PAR bZIP transcription factor	Homo sapiens	217-220
28988315-7	2018	The analysis of the association between polyphenol intake and biological parameters showed a significant negative association between polyphenol intake and the levels of systolic and diastolic blood pressure (SBP and DBP), GGT, and alanine aminotransferase (ALT) after adjusting for age, smoking habit, energy intake and alcohol intake.	Polyphenols	134-144	gamma-glutamyltransferase light chain family member 3	Homo sapiens	223-226
28988315-7	2018	The analysis of the association between polyphenol intake and biological parameters showed a significant negative association between polyphenol intake and the levels of systolic and diastolic blood pressure (SBP and DBP), GGT, and alanine aminotransferase (ALT) after adjusting for age, smoking habit, energy intake and alcohol intake.	Polyphenols	134-144	glutamic--pyruvic transaminase	Homo sapiens	232-256
28988315-8	2018	The GGT levels were inversely associated with the polyphenol intake from coffee, but not with that from green tea.	Polyphenols	50-60	gamma-glutamyltransferase light chain family member 3	Homo sapiens	4-7
28988315-9	2018	Multivariable linear regression analyses demonstrated that the subjects" GGT levels were negatively and independently associated with their polyphenol intake.	Polyphenols	140-150	gamma-glutamyltransferase light chain family member 3	Homo sapiens	73-76
28988315-10	2018	CONCLUSIONS: The intake of total polyphenol including coffee as a major contributor is inversely associated with the serum GGT concentration in Japanese males.	Polyphenols	33-43	gamma-glutamyltransferase light chain family member 3	Homo sapiens	123-126
29934164-3	2018	Polyphenols were determined by cLC-DAD.	Polyphenols	0-11	Gef1p	Saccharomyces cerevisiae S288C	31-34
30717558-0	2018	[Tea polyphenols delays human glomerular mesangial cells senescence induced by high glucose via regulating STAT3/miR-126/telomere signaling pathway activation].	Polyphenols	5-16	microRNA 126	Homo sapiens	113-120
30466981-16	2018	Furthermore, Rhodamine 123 and Calcein-AM were used to detect the effects of polyphenols on the activity of P-gp.	Polyphenols	77-88	phosphoglycolate phosphatase	Homo sapiens	108-112
30453587-10	2018	Indeed, if the paradigm of antioxidants is seductive, it is perhaps by their prooxidant effect that the polyphenols act, by an epigenetic process mediated by nrf2.	Polyphenols	104-115	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
30466981-23	2018	This study suggests that polyphenols, by modulating the activity of P-gp, may be used as chemosensitisers.	Polyphenols	25-36	phosphoglycolate phosphatase	Homo sapiens	68-72
30146950-4	2018	The total polyphenol and flavonoid content of LSM apple juice was approximately 2 times higher than that of blender apple juice because polyphenols and flavonoids can be used as substrates by PPO.	Polyphenols	10-20	polyphenol oxidase, chloroplastic	Malus domestica	192-195
30428519-7	2018	Both polyphenols significantly reduced CGN death induced by the nitric oxide donor, sodium nitroprusside (nitrosative stress).	Polyphenols	5-16	cingulin	Homo sapiens	39-42
30058211-0	2018	Elastin Stabilization Through Polyphenol and Ferric Chloride Combined Treatment for the Enhancement of Bioprosthetic Heart Valve Anticalcification.	Polyphenols	30-40	elastin	Homo sapiens	0-7
30142539-7	2018	Our main observations are the following: (1) Polyphenols formed stable complexes with albumin (K = 104-105 L/mol); (2) CAS and RES slightly displaced naproxen from human albumin, while albumin-binding of warfarin was not affected; (3) CAS and RES significantly inhibited CYP2C9, with CAS being as potent as the positive control warfarin; (4) each polyphenol significantly inhibited CYP3A4, with RES being stronger and CAS slightly weaker than the known inhibitor naringenin.	Polyphenols	45-56	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	271-277
30142539-7	2018	Our main observations are the following: (1) Polyphenols formed stable complexes with albumin (K = 104-105 L/mol); (2) CAS and RES slightly displaced naproxen from human albumin, while albumin-binding of warfarin was not affected; (3) CAS and RES significantly inhibited CYP2C9, with CAS being as potent as the positive control warfarin; (4) each polyphenol significantly inhibited CYP3A4, with RES being stronger and CAS slightly weaker than the known inhibitor naringenin.	Polyphenols	45-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	382-388
30146950-4	2018	The total polyphenol and flavonoid content of LSM apple juice was approximately 2 times higher than that of blender apple juice because polyphenols and flavonoids can be used as substrates by PPO.	Polyphenols	136-147	polyphenol oxidase, chloroplastic	Malus domestica	192-195
30400270-4	2018	Using a fluorescence-based DNA-endonuclease incision assay, we identified the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) as a potent inhibitor of ERCC1/XPF activity with an IC50 (half maximal inhibitory concentration) in the nanomolar range in biochemical assays.	Polyphenols	88-98	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	162-167
29637446-8	2018	Polyphenol/micronutrient supplementation tended to limit liver triglyceride infiltration through variations in fatty acid synthase, acyl coA oxidase, and possibly ATP-citrate lyase activities.	Polyphenols	0-10	ATP citrate lyase	Rattus norvegicus	163-180
30400270-4	2018	Using a fluorescence-based DNA-endonuclease incision assay, we identified the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) as a potent inhibitor of ERCC1/XPF activity with an IC50 (half maximal inhibitory concentration) in the nanomolar range in biochemical assays.	Polyphenols	88-98	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	168-171
30126067-6	2018	HPLC/DAD chromatographic procedures quantified polyphenols from active fraction (MME-F).	Polyphenols	47-58	membrane metalloendopeptidase	Homo sapiens	81-84
30125963-0	2018	The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis.	Polyphenols	4-14	sirtuin 1	Mus musculus	70-79
29957728-14	2018	Additionally, polyphenol supplementation may suppress CD11b expression on monocyte subsets at rest.	Polyphenols	14-24	integrin subunit alpha M	Homo sapiens	54-59
30560569-1	2018	The polyphenol-rich pomegranate juice (PJ) and the high-density lipoprotein (HDL)-associated paraoxonase1 (PON1) are known as potent atheroprotective antioxidants, but their effects on other tissues related to cardiovascular disease (CVD) remain unknown.	Polyphenols	4-14	paraoxonase 1	Mus musculus	107-111
30388863-0	2018	Preventive Effect of Raw Liubao Tea Polyphenols on Mouse Gastric Injuries Induced by HCl/Ethanol via Anti-Oxidative Stress.	Polyphenols	36-47	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	32-35
30388863-2	2018	This study is a basic research of the contained polyphenols (active substances) and detected preventive effects of polyphenols of raw Liubao tea (PRLT) on mouse gastric injuries induced by HCl/ethanol.	Polyphenols	115-126	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	141-144
30360466-6	2018	Polyphenols increase the binding of HDL to PON1, increasing the catalytic activity of PON1.	Polyphenols	0-11	paraoxonase 1	Homo sapiens	43-47
30411033-3	2018	In this work, we evaluated the activity of insulin-degrading enzyme (IDE) toward Abeta42 in the presence of resveratrol, a polyphenol found in red wine and grape juice.	Polyphenols	123-133	insulin degrading enzyme	Homo sapiens	43-67
30411033-3	2018	In this work, we evaluated the activity of insulin-degrading enzyme (IDE) toward Abeta42 in the presence of resveratrol, a polyphenol found in red wine and grape juice.	Polyphenols	123-133	insulin degrading enzyme	Homo sapiens	69-72
30411033-5	2018	Incubation with resveratrol results in a substantial increase in Abeta42 fragmentation compared to the control, signifying that the polyphenol sustains IDE-dependent degradation of Abeta42 and its fragments.	Polyphenols	132-142	insulin degrading enzyme	Homo sapiens	152-155
30593248-3	2018	Rapid resolution liquid chromatography coupled with quadrupole tandem mass spectrometry (RRLC-QqQ-MSn) was applied to compare the contents of polyphenols in ethanol extract, urine and feces.	Polyphenols	142-153	moesin	Rattus norvegicus	98-101
30360466-6	2018	Polyphenols increase the binding of HDL to PON1, increasing the catalytic activity of PON1.	Polyphenols	0-11	paraoxonase 1	Homo sapiens	86-90
30405413-4	2018	However, several plant species producing diverse classes of alkaloids, coumarins, terpenes, and polyphenols have been assessed for their anti-AChE activity, becoming potential candidates for new anti-AD drugs.	Polyphenols	96-107	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
30374328-0	2018	Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3beta and Inhibition of IRE1alpha-XBP1 Pathways.	Polyphenols	47-58	AKT serine/threonine kinase 1	Rattus norvegicus	106-109
30246823-6	2018	Modeling of molecular docking suggested that GCG preferably binds to the target alpha-glucosidase protein; this was confirmed by in vitro protein-polyphenol binding, where GCG had a binding rate about 4 times higher than that of EGCG.	Polyphenols	146-156	sucrase isomaltase (alpha-glucosidase)	Mus musculus	80-97
30416668-0	2018	Green tea polyphenols protect against preglomerular arteriopathy via the jagged1/notch1 pathway.	Polyphenols	10-21	jagged canonical Notch ligand 1	Rattus norvegicus	73-80
30416668-0	2018	Green tea polyphenols protect against preglomerular arteriopathy via the jagged1/notch1 pathway.	Polyphenols	10-21	notch receptor 1	Rattus norvegicus	81-87
30374328-0	2018	Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3beta and Inhibition of IRE1alpha-XBP1 Pathways.	Polyphenols	47-58	glycogen synthase kinase 3 beta	Rattus norvegicus	110-119
30279388-1	2018	Polyphenols Modulate Interferon Gamma/Histamine-Induced Inflammation in Human NCTC 2544 Keratinocytes.	Polyphenols	0-11	interferon gamma	Homo sapiens	21-37
30315184-4	2018	Here we prepared another polyphenol, glyceollin I from stressed soybeans, and identified it as a major inhibitor of the Eleanor RNA cloud and ESR1 mRNA transcription.	Polyphenols	25-35	ethylene-responsive transcription factor ESR2	Glycine max	142-146
30305045-3	2018	Resveratrol, a sirtuin 1 (Sirt1) activator, is a polyphenol compound found in red wine that has protective functions in neuropathology paradigms.	Polyphenols	49-59	sirtuin 1	Mus musculus	15-24
30305045-3	2018	Resveratrol, a sirtuin 1 (Sirt1) activator, is a polyphenol compound found in red wine that has protective functions in neuropathology paradigms.	Polyphenols	49-59	sirtuin 1	Mus musculus	26-31
29981370-0	2018	Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration.	Polyphenols	35-46	mitogen-activated protein kinase 1	Homo sapiens	10-13
30119199-6	2018	Hence, the present review discusses peer-reviewed published literature till date on this aspect and highlights that polyphenols could effectively inhibit the formation of calcium oxalate urinary stones (most common renal stone), correlating with their antioxidant, anti-inflammatory, diuretic and angiotensin-converting enzyme (ACE) inhibition.	Polyphenols	116-127	angiotensin I converting enzyme	Homo sapiens	297-326
30119199-6	2018	Hence, the present review discusses peer-reviewed published literature till date on this aspect and highlights that polyphenols could effectively inhibit the formation of calcium oxalate urinary stones (most common renal stone), correlating with their antioxidant, anti-inflammatory, diuretic and angiotensin-converting enzyme (ACE) inhibition.	Polyphenols	116-127	angiotensin I converting enzyme	Homo sapiens	328-331
30009889-5	2018	Some natural products including polyphenols, terpenoids and alkaloids can induce Nrf2 expression as a key protein in the antioxidant defense system of hepatocytes.	Polyphenols	32-43	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
30189583-5	2018	Polyphenols are able to bind to estrogen receptor alpha (ERalpha) and beta (ERbeta), and therefore induce biological effects in human cells through mimicking or inhibiting the action of endogenous estrogens, even at low concentrations.	Polyphenols	0-11	estrogen receptor 1	Homo sapiens	32-55
29951779-10	2018	Additionally, increased shedding of CD16 and expression of CD66b suggested sites via which the polyphenol achieved improved neutrophil motility.	Polyphenols	95-105	Fc gamma receptor IIIa	Homo sapiens	36-40
29951779-10	2018	Additionally, increased shedding of CD16 and expression of CD66b suggested sites via which the polyphenol achieved improved neutrophil motility.	Polyphenols	95-105	CEA cell adhesion molecule 8	Homo sapiens	59-64
30248132-0	2018	ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols.	Polyphenols	79-90	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	4-17
30248132-3	2018	In this study, to prevent excess inflammation, we focused on DAMPs-mediated signaling that promotes LPS-stimulated inflammatory responses, especially adenosine 5"-triphosphate (ATP)-triggered signaling through the ionotropic purinergic receptor 7 (P2X7R), as a potential new anti-inflammatory target of natural polyphenols.	Polyphenols	311-322	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	248-253
30248132-6	2018	We then screened 42 polyphenols for inhibiting the ATP/P2X7R-induced calcium influx, and found that several polyphenols exhibited significant inhibitory effects.	Polyphenols	20-31	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	55-60
30248132-6	2018	We then screened 42 polyphenols for inhibiting the ATP/P2X7R-induced calcium influx, and found that several polyphenols exhibited significant inhibitory effects.	Polyphenols	108-119	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	55-60
30183039-8	2018	Dietary polyphenol EGCG could serve as a promising PXR/CAR activator and therapeutic intervention in diabetes.	Polyphenols	8-18	nuclear receptor subfamily 1, group I, member 2	Mus musculus	51-54
30183039-8	2018	Dietary polyphenol EGCG could serve as a promising PXR/CAR activator and therapeutic intervention in diabetes.	Polyphenols	8-18	nuclear receptor subfamily 1, group I, member 3	Mus musculus	55-58
30206280-0	2018	Seasonal consumption of polyphenol-rich fruits affects the hypothalamic leptin signaling system in a photoperiod-dependent mode.	Polyphenols	24-34	leptin	Rattus norvegicus	72-78
30206280-1	2018	Leptin has a central role in the maintenance of energy homeostasis, and its sensitivity is influenced by both the photoperiod and dietary polyphenols.	Polyphenols	138-149	leptin	Rattus norvegicus	0-6
30206280-2	2018	The aim of this study was to investigate the effect of seasonal consumption of polyphenol-rich fruits on the hypothalamic leptin signaling system in non-obese and obese animals placed under different photoperiods.	Polyphenols	79-89	leptin	Rattus norvegicus	122-128
30206280-7	2018	In conclusion, the consumption of rich-polyphenol fruits may increase leptin sensitivity through the modulation of the hypothalamic leptin signal pathway mainly when consumed in the SD photoperiod.	Polyphenols	39-49	leptin	Rattus norvegicus	70-76
30206280-7	2018	In conclusion, the consumption of rich-polyphenol fruits may increase leptin sensitivity through the modulation of the hypothalamic leptin signal pathway mainly when consumed in the SD photoperiod.	Polyphenols	39-49	leptin	Rattus norvegicus	132-138
30201943-0	2018	Polyphenols in Liubao Tea Can Prevent CCl4-Induced Hepatic Damage in Mice through Its Antioxidant Capacities.	Polyphenols	0-11	chemokine (C-C motif) ligand 4	Mus musculus	38-42
30201943-1	2018	The present study investigated the preventive effect of polyphenols in Liubao tea (PLT) on carbon tetrachloride (CCl4)-induced liver injury in mice.	Polyphenols	56-67	chemokine (C-C motif) ligand 4	Mus musculus	113-117
30235254-6	2018	Moreover, we have observed that this polyphenol modulates the transcription and translation of members of the PGC-1alpha/ERRalpha and PGC-1alpha/Nrf2 pathways.	Polyphenols	37-47	PPARG coactivator 1 alpha	Homo sapiens	110-120
30235254-6	2018	Moreover, we have observed that this polyphenol modulates the transcription and translation of members of the PGC-1alpha/ERRalpha and PGC-1alpha/Nrf2 pathways.	Polyphenols	37-47	estrogen related receptor alpha	Homo sapiens	121-129
30235254-6	2018	Moreover, we have observed that this polyphenol modulates the transcription and translation of members of the PGC-1alpha/ERRalpha and PGC-1alpha/Nrf2 pathways.	Polyphenols	37-47	PPARG coactivator 1 alpha	Homo sapiens	134-144
30235254-6	2018	Moreover, we have observed that this polyphenol modulates the transcription and translation of members of the PGC-1alpha/ERRalpha and PGC-1alpha/Nrf2 pathways.	Polyphenols	37-47	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
30098786-1	2018	Resveratrol is a natural polyphenol with several therapeutic effects, in particular, inducing p53-dependent cell cycle arrest and/or apoptosis in tumor cells.	Polyphenols	25-35	transformation related protein 53, pseudogene	Mus musculus	94-97
30189583-5	2018	Polyphenols are able to bind to estrogen receptor alpha (ERalpha) and beta (ERbeta), and therefore induce biological effects in human cells through mimicking or inhibiting the action of endogenous estrogens, even at low concentrations.	Polyphenols	0-11	estrogen receptor 1	Homo sapiens	57-64
30189583-5	2018	Polyphenols are able to bind to estrogen receptor alpha (ERalpha) and beta (ERbeta), and therefore induce biological effects in human cells through mimicking or inhibiting the action of endogenous estrogens, even at low concentrations.	Polyphenols	0-11	estrogen receptor 2	Homo sapiens	76-82
30260512-2	2018	Various literatures reported that natural polyphenols could act as a beta-sheet breaker and therefore, treated as a potential therapeutics against various aggregated proteins involved in neurodegenerative disorders.	Polyphenols	42-53	amyloid beta precursor protein	Homo sapiens	67-73
30260512-3	2018	Through computational perspective, molecular docking, quantum chemical studies, and discrete molecular dynamics were implemented to study the binding and structural effect of natural polyphenols, kaempferol, and kaempferide on mutant SOD1.	Polyphenols	183-194	superoxide dismutase 1	Homo sapiens	234-238
30070707-4	2018	One metabolic transformation is due to the enzyme catechol-O-methyltransferase (COMT), which methylates polyphenols such as anthocyanins.	Polyphenols	104-115	catechol-O-methyltransferase	Homo sapiens	50-78
29770579-0	2018	Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer"s disease.	Polyphenols	28-39	butyrylcholinesterase	Homo sapiens	0-14
29770579-8	2018	In the current article, we have summarized the role of various polyphenols, namely quercetin, resveratrol, curcumin, gallocatechins, cinnamic acid, caffeine, and caffeic acid as an inhibitor of cholinesterase for the treatment of AD.	Polyphenols	63-74	butyrylcholinesterase	Homo sapiens	194-208
30070707-4	2018	One metabolic transformation is due to the enzyme catechol-O-methyltransferase (COMT), which methylates polyphenols such as anthocyanins.	Polyphenols	104-115	catechol-O-methyltransferase	Homo sapiens	80-84
29976995-0	2018	Sir-2.1 mediated attenuation of alpha-synuclein expression by Alaskan bog blueberry polyphenols in a transgenic model of Caenorhabditis elegans.	Polyphenols	84-95	synuclein alpha	Homo sapiens	32-47
30310409-4	2018	In order to find other ways to lower apoCIII we in this study tested non-alcoholic red wine with medium and high concentrations of polyphenols and the lipid-lowering drug, fenofibrate, both reported to decrease the expression of apoCIII by activating peroxisome proliferator-activated receptors.	Polyphenols	131-142	apolipoprotein C3	Rattus norvegicus	229-236
29606470-0	2018	Reducing the allergenic capacity of beta-lactoglobulin by covalent conjugation with dietary polyphenols.	Polyphenols	92-103	beta-lactoglobulin	Bos taurus	36-54
30018026-1	2018	The polyphenol resveratrol activates stimulus-regulated transcription factors, including activator protein-1 (AP-1).	Polyphenols	4-14	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-108
30018026-1	2018	The polyphenol resveratrol activates stimulus-regulated transcription factors, including activator protein-1 (AP-1).	Polyphenols	4-14	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-114
29980703-3	2018	The plant-derived polyphenols, carnosol and curcumin, have been identified as candidate HO-1 inducers however there has been little investigation into their effects on human immune cells.	Polyphenols	18-29	heme oxygenase 1	Homo sapiens	88-92
29976995-0	2018	Sir-2.1 mediated attenuation of alpha-synuclein expression by Alaskan bog blueberry polyphenols in a transgenic model of Caenorhabditis elegans.	Polyphenols	84-95	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	0-7
29908722-0	2018	Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-kappaB signalling pathway.	Polyphenols	24-34	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	112-117
29986680-2	2018	Recent studies show that some polyphenols exert their antioxidant properties through regulation of protein kinase C-alpha (PKC-alpha) and NADPH oxidase (Nox) signaling.	Polyphenols	30-41	protein kinase C alpha	Homo sapiens	123-132
29734116-0	2018	Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation.	Polyphenols	0-10	microRNA 335	Mus musculus	88-95
29864924-0	2018	Antioxidant mechanism of polyphenol-rich Nymphaea nouchali leaf extract protecting DNA damage and attenuating oxidative stress-induced cell death via Nrf2-mediated heme-oxygenase-1 induction coupled with ERK/p38 signaling pathway.	Polyphenols	25-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	150-154
29864924-0	2018	Antioxidant mechanism of polyphenol-rich Nymphaea nouchali leaf extract protecting DNA damage and attenuating oxidative stress-induced cell death via Nrf2-mediated heme-oxygenase-1 induction coupled with ERK/p38 signaling pathway.	Polyphenols	25-35	mitogen-activated protein kinase 1	Mus musculus	204-207
29864924-0	2018	Antioxidant mechanism of polyphenol-rich Nymphaea nouchali leaf extract protecting DNA damage and attenuating oxidative stress-induced cell death via Nrf2-mediated heme-oxygenase-1 induction coupled with ERK/p38 signaling pathway.	Polyphenols	25-35	mitogen-activated protein kinase 14	Mus musculus	208-211
29936451-2	2018	Green tea polyphenol inhibits these malignant behaviors and suppresses human antigen R (HuR) expression, which is associated with malignant aggressiveness.	Polyphenols	10-20	ELAV like RNA binding protein 1	Homo sapiens	88-91
29753753-5	2018	Polyphenols, through their antioxidant and anti-inflammatory properties, modulate several cascades and effectors involved in the regulation of AN (e.g., SIRT1, Wnt, NF-kappaB and Nrf2, among others).	Polyphenols	0-11	sirtuin 1	Homo sapiens	153-158
29753753-5	2018	Polyphenols, through their antioxidant and anti-inflammatory properties, modulate several cascades and effectors involved in the regulation of AN (e.g., SIRT1, Wnt, NF-kappaB and Nrf2, among others).	Polyphenols	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	179-183
29807418-14	2018	This study suggests that Dgat2 is an inducible gene rapidly responding to stimulators such as polyphenols whose protein product DGAT2 plays an important role in fat biosynthesis.	Polyphenols	94-105	diacylglycerol O-acyltransferase 2	Mus musculus	25-30
29604377-0	2018	Pomegranate polyphenols and urolithin A inhibit alpha-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells.	Polyphenols	12-23	sucrase isomaltase (alpha-glucosidase)	Mus musculus	48-65
29604377-0	2018	Pomegranate polyphenols and urolithin A inhibit alpha-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells.	Polyphenols	12-23	dipeptidylpeptidase 4	Mus musculus	67-89
29604377-0	2018	Pomegranate polyphenols and urolithin A inhibit alpha-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells.	Polyphenols	12-23	lipase, endothelial	Mus musculus	91-97
29807418-14	2018	This study suggests that Dgat2 is an inducible gene rapidly responding to stimulators such as polyphenols whose protein product DGAT2 plays an important role in fat biosynthesis.	Polyphenols	94-105	diacylglycerol O-acyltransferase 2	Mus musculus	128-133
30320189-4	2018	Resveratrol is a natural polyphenol that reportedly prevents cerebral ischemia injury by regulating the expression of PI3K/AKT/mTOR.	Polyphenols	25-35	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
30320189-4	2018	Resveratrol is a natural polyphenol that reportedly prevents cerebral ischemia injury by regulating the expression of PI3K/AKT/mTOR.	Polyphenols	25-35	mechanistic target of rapamycin kinase	Rattus norvegicus	127-131
29882783-4	2018	This study describes the development of field template, field-based qualitative structure-activity relationship (SAR) model demonstrating DPP-4 inhibitors of natural origin, and the same model is used to screen virtually focused food database composed of polyphenols as potential DPP-4 inhibitors.	Polyphenols	255-266	dipeptidyl peptidase 4	Homo sapiens	280-285
29174054-6	2018	According to the results, grape polyphenols altered mainly the expression of cytoskeleton and differentiation-associated genes, while coffee compounds had a more profound effect, on the expression levels of many metabolic and antioxidant genes possibly through the nuclear factor (erythroid-derived 2) like-2 (Nrf2) pathway.	Polyphenols	32-43	NFE2 like bZIP transcription factor 2	Homo sapiens	265-308
29616249-5	2018	Polyphenols, which are powerful phytochemicals, act as direct and indirect antioxidants, reduce the inflammatory response, improve proteostasis and mitochondrial biogenesis, modulate many cell signaling pathways, have a major role in cytoprotection, are Nrf2/ARE activators, down-regulate the NFkappaB system, promote anticancer potential, and prevent cell senescence.	Polyphenols	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	254-258
29703769-3	2018	Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk.	Polyphenols	71-81	cytochrome c oxidase subunit 8A	Homo sapiens	32-35
29616249-5	2018	Polyphenols, which are powerful phytochemicals, act as direct and indirect antioxidants, reduce the inflammatory response, improve proteostasis and mitochondrial biogenesis, modulate many cell signaling pathways, have a major role in cytoprotection, are Nrf2/ARE activators, down-regulate the NFkappaB system, promote anticancer potential, and prevent cell senescence.	Polyphenols	0-11	nuclear factor kappa B subunit 1	Homo sapiens	293-301
29751678-1	2018	(-)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas.	Polyphenols	51-61	fatty acid synthase	Homo sapiens	156-175
29751678-1	2018	(-)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas.	Polyphenols	51-61	fatty acid synthase	Homo sapiens	177-181
30271926-5	2018	We show that dietary polyphenols promote memory function and offer a general method to map cellular subpopulations influenced by dietary polyphenols, in part through the mechanism of c-Fos expression enhancement.	Polyphenols	21-32	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-188
28800275-0	2018	Polyphenol-Rich Fraction of Parquetina nigrescens Mitigates Dichlorvos-Induced Cardiorenal Dysfunction Through Reduction in Cardiac Nitrotyrosine and Renal p38 Expressions in Wistar Rats.	Polyphenols	0-10	mitogen activated protein kinase 14	Rattus norvegicus	156-159
30271926-5	2018	We show that dietary polyphenols promote memory function and offer a general method to map cellular subpopulations influenced by dietary polyphenols, in part through the mechanism of c-Fos expression enhancement.	Polyphenols	137-148	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-188
29641499-5	2018	The B-2 cultivar had the highest antioxidant potential than others because it contained the highest levels of polyphenols, especially anthocyanin, flavone, and phenolic acid; furthermore, this cultivar displayed anti-tumor effects against the human lung adenocarcinoma cell line A549, human hepatoma cell line Bel7402, human cancer colorectal adenoma cell line HCT-8, and HT-29 human colon cancer cell line.	Polyphenols	110-121	immunoglobulin kappa variable 5-2	Homo sapiens	4-7
29668036-8	2018	The results showed that grape seeds were rich in anthocyanins and polyphenols and other active substances, inhibited alpha-glucosidase and alpha-amylase activity, which provide background and practical knowledge for the deep-processed products of grape seeds with high added value.	Polyphenols	66-77	sucrase-isomaltase	Homo sapiens	117-134
29550472-3	2018	We investigated if a polyphenol, pentagalloyl glucose (PGG) can increase elastin production in pulmonary fibroblasts.	Polyphenols	21-31	elastin	Rattus norvegicus	73-80
29606008-0	2018	Mulberry Polyphenol Extract Inhibits FAK/Src/PI3K Complex and Related Signaling To Regulate the Migration in A7r5 Cells.	Polyphenols	9-19	protein tyrosine kinase 2	Rattus norvegicus	37-40
29606008-0	2018	Mulberry Polyphenol Extract Inhibits FAK/Src/PI3K Complex and Related Signaling To Regulate the Migration in A7r5 Cells.	Polyphenols	9-19	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	41-44
27646710-5	2018	The antioxidant polyphenols inhibit the AGEs at different levels of the glycation process in the following ways: (1) prevention of Amadori adduct oxidation; (2) trapping reactive dycarbonyl compounds; (3) attenuation of receptor for AGEs (RAGE) expression.	Polyphenols	16-27	long intergenic non-protein coding RNA 914	Homo sapiens	239-243
29542686-7	2018	Instead, I comment on how curcumin and dietary polyphenol research has enriched our knowledge of insulin signaling, including the presentation of my perspectives on how these studies will add to our understanding of the famous hepatic insulin function paradox.	Polyphenols	47-57	insulin	Homo sapiens	97-104
29525677-2	2018	Several studies have suggested that dietary antioxidants (such as polyphenols and berberine) may counteract oxidative stress through the involvement of the Sirtuin 1/Adenosine Monophosphate-Activated Protein Kinase (SIRT1/AMPK) pathway.	Polyphenols	66-77	sirtuin 1	Homo sapiens	156-214
29525677-2	2018	Several studies have suggested that dietary antioxidants (such as polyphenols and berberine) may counteract oxidative stress through the involvement of the Sirtuin 1/Adenosine Monophosphate-Activated Protein Kinase (SIRT1/AMPK) pathway.	Polyphenols	66-77	sirtuin 1	Homo sapiens	216-221
29525677-2	2018	Several studies have suggested that dietary antioxidants (such as polyphenols and berberine) may counteract oxidative stress through the involvement of the Sirtuin 1/Adenosine Monophosphate-Activated Protein Kinase (SIRT1/AMPK) pathway.	Polyphenols	66-77	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	222-226
29532213-4	2018	Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-alpha) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2).	Polyphenols	10-21	toll like receptor 4	Homo sapiens	155-175
29707158-11	2018	Further, this review, tied with important findings from our laboratory, demonstrates that polyphenols induce CXCR3 expression on regulatory T cells and increases CXCR3 ligands in the tumor microenvironment, which act together to suppress colorectal cancer through a differential mechanism discussed herewith.	Polyphenols	90-101	C-X-C motif chemokine receptor 3	Homo sapiens	109-114
29707158-11	2018	Further, this review, tied with important findings from our laboratory, demonstrates that polyphenols induce CXCR3 expression on regulatory T cells and increases CXCR3 ligands in the tumor microenvironment, which act together to suppress colorectal cancer through a differential mechanism discussed herewith.	Polyphenols	90-101	C-X-C motif chemokine receptor 3	Homo sapiens	162-167
29363005-6	2018	Increased levels of caspase-3 and 9 in cochlea were observed with age and this effect was attenuated by polyphenol treatment.	Polyphenols	104-114	caspase 3	Rattus norvegicus	20-35
29363005-7	2018	In addition, ATP and Bcl-2 levels in older rats were recovered after administration of polyphenols, while Bax and p53 levels protein decreased.	Polyphenols	87-98	BCL2, apoptosis regulator	Rattus norvegicus	21-26
29681859-5	2018	Considering the crucial role of proline metabolism and proline dehydrogenase/proline oxidase (PRODH/POX) in the regulation of cancer cell survival/apoptosis, we studied these processes in polyphenol-treated CAL-27 cells.	Polyphenols	188-198	proline dehydrogenase 1	Homo sapiens	94-103
29681859-6	2018	All studied polyphenols evoked anti-proliferative activity, accompanied by increased PRODH/POX, P53, active caspases-3 and -9 expressions and decreased collagen biosynthesis, prolidase activity and proline concentration in CAL-27 cells.	Polyphenols	12-23	proline dehydrogenase 1	Homo sapiens	85-90
29681859-6	2018	All studied polyphenols evoked anti-proliferative activity, accompanied by increased PRODH/POX, P53, active caspases-3 and -9 expressions and decreased collagen biosynthesis, prolidase activity and proline concentration in CAL-27 cells.	Polyphenols	12-23	proline dehydrogenase 1	Homo sapiens	91-94
29681859-6	2018	All studied polyphenols evoked anti-proliferative activity, accompanied by increased PRODH/POX, P53, active caspases-3 and -9 expressions and decreased collagen biosynthesis, prolidase activity and proline concentration in CAL-27 cells.	Polyphenols	12-23	tumor protein p53	Homo sapiens	96-125
29681859-6	2018	All studied polyphenols evoked anti-proliferative activity, accompanied by increased PRODH/POX, P53, active caspases-3 and -9 expressions and decreased collagen biosynthesis, prolidase activity and proline concentration in CAL-27 cells.	Polyphenols	12-23	peptidase D	Homo sapiens	175-184
29681859-7	2018	These data suggest that polyphenols of propolis induce PRODH/POX-dependent apoptosis through up-regulation of mitochondrial proline degradation and down-regulation of proline utilization for collagen biosynthesis.	Polyphenols	24-35	proline dehydrogenase 1	Homo sapiens	55-60
29681859-7	2018	These data suggest that polyphenols of propolis induce PRODH/POX-dependent apoptosis through up-regulation of mitochondrial proline degradation and down-regulation of proline utilization for collagen biosynthesis.	Polyphenols	24-35	proline dehydrogenase 1	Homo sapiens	61-64
29425676-4	2018	METHODS: The interaction of polyphenols with PDIA3 purified protein was explored by fluorescence quenching and calorimetric techniques and their effect on PDIA3 activity was investigated.	Polyphenols	28-39	protein disulfide isomerase family A member 3	Homo sapiens	45-50
29532213-4	2018	Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-alpha) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2).	Polyphenols	10-21	toll like receptor 4	Homo sapiens	177-181
29532213-4	2018	Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-alpha) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2).	Polyphenols	10-21	tumor necrosis factor	Homo sapiens	274-283
29532213-4	2018	Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-alpha) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2).	Polyphenols	10-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	499-515
29532213-4	2018	Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-alpha) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2).	Polyphenols	10-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	517-522
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	interleukin 6	Mus musculus	98-111
29475984-0	2018	Correction: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.	Polyphenols	22-32	toll interacting protein	Homo sapiens	50-56
29475984-0	2018	Correction: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.	Polyphenols	22-32	E74 like ETS transcription factor 1	Homo sapiens	83-88
28808887-6	2018	Polyphenols reversed the age-induced deficits in monoaminergic neurotransmitters (serotonin, noradrenaline, and dopamine), increasing TPH and TH activity.	Polyphenols	0-11	tryptophan hydroxylase 1	Rattus norvegicus	134-137
28641051-13	2018	Furthermore, polyphenols induce several defensive genes such as Nrf2, AMPK, superoxide dismutase, catalase, heme oxygenase (HO), Sirt1, and other important functional proteins to serve mitochondrial biogenesis.	Polyphenols	13-24	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
28641051-13	2018	Furthermore, polyphenols induce several defensive genes such as Nrf2, AMPK, superoxide dismutase, catalase, heme oxygenase (HO), Sirt1, and other important functional proteins to serve mitochondrial biogenesis.	Polyphenols	13-24	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	70-74
28641051-13	2018	Furthermore, polyphenols induce several defensive genes such as Nrf2, AMPK, superoxide dismutase, catalase, heme oxygenase (HO), Sirt1, and other important functional proteins to serve mitochondrial biogenesis.	Polyphenols	13-24	catalase	Homo sapiens	98-106
28641051-13	2018	Furthermore, polyphenols induce several defensive genes such as Nrf2, AMPK, superoxide dismutase, catalase, heme oxygenase (HO), Sirt1, and other important functional proteins to serve mitochondrial biogenesis.	Polyphenols	13-24	sirtuin 1	Homo sapiens	129-134
29089337-3	2018	Thus, a number of preclinical and clinical investigations have shown the beneficial effect of curcumin (and other dietary polyphenols) in attenuating body weight gain, improving insulin sensitivity, and preventing diabetes development in rodent models and prediabetic subjects.	Polyphenols	122-133	insulin	Homo sapiens	178-185
29089337-4	2018	Other intervention studies with dietary polyphenols have also found improvements in insulin resistance.	Polyphenols	40-51	insulin	Homo sapiens	84-91
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	interleukin 6	Mus musculus	113-117
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	tumor necrosis factor	Mus musculus	120-154
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	tumor necrosis factor	Mus musculus	156-165
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	interferon gamma	Mus musculus	168-184
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	interferon gamma	Mus musculus	186-195
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	tachykinin 1	Mus musculus	213-224
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	endothelin 1	Mus musculus	235-247
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	vasoactive intestinal polypeptide	Mus musculus	336-339
29284788-0	2018	Polyphenol-rich curry made with mixed spices and vegetables increases postprandial plasma GLP-1 concentration in a dose-dependent manner.	Polyphenols	0-10	glucagon	Homo sapiens	90-95
29341416-9	2018	Importantly, after prolonged exposure to resveratrol (14 days), the beneficial influence of the polyphenol on insulin release is lost.	Polyphenols	96-106	insulin	Homo sapiens	110-117
29773105-0	2018	[Protective role of green tea polyphenols in intestinal mucosal barrier function of mice with colitis induced by TNBS through inhibiting JAK2/STAT3 pathway].	Polyphenols	30-41	Janus kinase 2	Mus musculus	137-141
29773105-0	2018	[Protective role of green tea polyphenols in intestinal mucosal barrier function of mice with colitis induced by TNBS through inhibiting JAK2/STAT3 pathway].	Polyphenols	30-41	signal transducer and activator of transcription 3	Mus musculus	142-147
29322133-0	2018	Anti-fibrotic activity of polyphenol-enriched sugarcane extract in rats via inhibition of p38 and JNK phosphorylation.	Polyphenols	26-36	mitogen activated protein kinase 14	Rattus norvegicus	90-93
30023810-0	2018	Effects of Natural Polyphenols on the Expression of Drug Efflux Transporter P-Glycoprotein in Human Intestinal Cells.	Polyphenols	19-30	ATP binding cassette subfamily B member 1	Homo sapiens	76-90
30023810-2	2018	We previously reported that dietary polyphenols such as quercetin, curcumin, honokiol, magnolol, caffeic acid phenetyl ester (CAPE), xanthohumol, and anacardic acid inhibit P-glycoprotein-mediated drug transport.	Polyphenols	36-47	ATP binding cassette subfamily B member 1	Homo sapiens	173-187
30023810-3	2018	In the present study, we investigated the effects of polyphenols on the expression of P-glycoprotein using human intestinal epithelial LS174T cells and a reporter plasmid expressing 10.2 kbp of the upstream regulatory region of MDR1.	Polyphenols	53-64	ATP binding cassette subfamily B member 1	Homo sapiens	86-100
30023810-4	2018	Honokiol, magnolol, CAPE, xanthohumol, and anacardic acid activated the MDR1 promoter in LS174T cells, and the cellular uptake of rhodamine 123 and calcein-AM, fluorescent substrates of P-glycoprotein, decreased in polyphenol-treated LS174T cells.	Polyphenols	215-225	ATP binding cassette subfamily B member 1	Homo sapiens	186-200
30023810-5	2018	These results suggest that dietary natural polyphenols can induce the drug efflux transporter P-glycoprotein and have the potential to promote food-drug interactions.	Polyphenols	43-54	ATP binding cassette subfamily B member 1	Homo sapiens	94-108
29322133-0	2018	Anti-fibrotic activity of polyphenol-enriched sugarcane extract in rats via inhibition of p38 and JNK phosphorylation.	Polyphenols	26-36	mitogen-activated protein kinase 8	Rattus norvegicus	98-101
29507653-4	2018	The striking capacities in remitting oxidative stress, lipid metabolism, insulin resistance, and inflammation put polyphenols in the spotlight for the therapies of liver diseases.	Polyphenols	114-125	insulin	Homo sapiens	73-80
29248832-0	2018	Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation.	Polyphenols	0-10	insulin receptor substrate 1	Rattus norvegicus	138-142
29248832-0	2018	Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation.	Polyphenols	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
29284788-2	2018	Evidence is emerging that dietary bioactive phytochemicals such as polyphenols can increase GLP-1 concentration in vivo.	Polyphenols	67-78	glucagon	Homo sapiens	92-97
29284788-3	2018	Spices are rich in polyphenols and have oro-sensory properties, both of which can increase GLP-1 secretion.	Polyphenols	19-30	glucagon	Homo sapiens	91-96
29284788-9	2018	Consumption of polyphenol rich mixed spices and vegetables can therefore increase in vivo GLP-1 concentration.	Polyphenols	15-25	glucagon	Homo sapiens	90-95
29284135-4	2018	Our results showed that MUD 1 presented the highest (P &lt; .05) fiber, protein, carbohydrate, polyphenol and flavonoid concentration, as well as the highest (P &lt; .05) total antioxidant capacity than the MUD 2 samples.	Polyphenols	95-105	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	24-29
29293312-2	2018	The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood.	Polyphenols	74-84	myeloperoxidase	Homo sapiens	22-37
29063666-3	2018	Previously, we demonstrated that induction of antioxidant enzymes by Nrf2 activation using Nrf2-gene transfer, an ETGE-peptide or polyphenols, successfully ameliorated RANKL-dependent osteoclastogenesis.	Polyphenols	130-141	nuclear factor, erythroid derived 2, like 2	Mus musculus	69-73
29063666-3	2018	Previously, we demonstrated that induction of antioxidant enzymes by Nrf2 activation using Nrf2-gene transfer, an ETGE-peptide or polyphenols, successfully ameliorated RANKL-dependent osteoclastogenesis.	Polyphenols	130-141	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	168-173
29288757-5	2018	It is thought that dietary polyphenols may ameliorate obesity-related insulin resistance by attenuating inflammatory responses and oxidative stress.	Polyphenols	27-38	insulin	Homo sapiens	70-77
29288757-8	2018	Polyphenol intake can prevent high-fat-diet-induced insulin resistance via cell surface G protein-coupled estrogen receptors by upregulating the expression of related genes, and their pathways, which are responsible for the insulin sensitivity.	Polyphenols	0-10	insulin	Homo sapiens	52-59
29288757-8	2018	Polyphenol intake can prevent high-fat-diet-induced insulin resistance via cell surface G protein-coupled estrogen receptors by upregulating the expression of related genes, and their pathways, which are responsible for the insulin sensitivity.	Polyphenols	0-10	insulin	Homo sapiens	224-231
29278293-0	2018	Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice.	Polyphenols	10-20	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
29278293-0	2018	Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice.	Polyphenols	10-20	glucosidase beta 2	Mus musculus	89-98
28676015-0	2018	Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging.	Polyphenols	33-44	sirtuin 1	Homo sapiens	48-53
28676015-5	2018	RESULTS: The antiaging effects of polyphenols could be due to several related mechanisms, among which are the prevention of oxidative stress, SIRT1 activation and inflammaging modulation, via regulation of some signaling pathways, such as NF-kappaB.	Polyphenols	34-45	sirtuin 1	Homo sapiens	142-147
28676015-6	2018	CONCLUSION: In this review, we describe the positive effects of polyphenols on the prevention of the changes that occur during aging in the brain and their consequences on cognition, emphasizing the possible modulation of inflammaging by polyphenols through a SIRT1-mediated mechanism.	Polyphenols	64-75	sirtuin 1	Homo sapiens	260-265
28676015-6	2018	CONCLUSION: In this review, we describe the positive effects of polyphenols on the prevention of the changes that occur during aging in the brain and their consequences on cognition, emphasizing the possible modulation of inflammaging by polyphenols through a SIRT1-mediated mechanism.	Polyphenols	238-249	sirtuin 1	Homo sapiens	260-265
29293312-2	2018	The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood.	Polyphenols	74-84	myeloperoxidase	Homo sapiens	39-42
29293312-2	2018	The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood.	Polyphenols	74-84	myeloperoxidase	Homo sapiens	212-215
29293312-2	2018	The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood.	Polyphenols	115-126	myeloperoxidase	Homo sapiens	22-37
29293312-2	2018	The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood.	Polyphenols	115-126	myeloperoxidase	Homo sapiens	39-42
29293312-2	2018	The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood.	Polyphenols	115-126	myeloperoxidase	Homo sapiens	212-215
29128095-5	2018	On the other hand, the polyphenols extracts showed an interesting radical scavenging capacity and a potential ability to inhibit inflammatory markers at 90% for NO release and 75% for iNOS expression.	Polyphenols	23-34	nitric oxide synthase 2, inducible	Mus musculus	184-188
29269293-0	2018	Activation of macrophages by a laccase-polymerized polyphenol is dependent on phosphorylation of Rac1.	Polyphenols	51-61	Rac family small GTPase 1	Mus musculus	97-101
29342922-10	2018	In this review, we describe mechanisms of proteolytic enzymes (MMP-9 and plasminogen activation system), their role in Down syndrome, their inhibition by EGCG, possible degradation of this polyphenol and the ability of EGCG and its degradation products to cross the blood-brain barrier.	Polyphenols	189-199	matrix metallopeptidase 9	Homo sapiens	63-68
29342865-1	2018	(Poly)phenols and, specifically, phlorotannins present in brown seaweeds have previously been shown to inhibit alpha-amylase and alpha-glucosidase, key enzymes involved in the breakdown and intestinal absorption of carbohydrates.	Polyphenols	0-13	sucrase-isomaltase	Homo sapiens	129-146
29351230-0	2018	Comparison of Antioxidative Effects of Insect Tea and Its Raw Tea (Kuding Tea) Polyphenols in Kunming Mice.	Polyphenols	79-90	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	62-65
29351230-0	2018	Comparison of Antioxidative Effects of Insect Tea and Its Raw Tea (Kuding Tea) Polyphenols in Kunming Mice.	Polyphenols	79-90	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	62-65
29351230-2	2018	Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation.	Polyphenols	11-22	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	7-10
29351230-2	2018	Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation.	Polyphenols	58-69	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	41-44
29351230-2	2018	Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation.	Polyphenols	58-69	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	41-44
29351230-2	2018	Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation.	Polyphenols	58-69	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	41-44
29351230-2	2018	Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation.	Polyphenols	58-69	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	41-44
29351230-3	2018	The present study was designed to compare the antioxidative effects of insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) on d-galactose-induced oxidation in Kunming (KM) mice.	Polyphenols	82-93	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	78-81
29351230-3	2018	The present study was designed to compare the antioxidative effects of insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) on d-galactose-induced oxidation in Kunming (KM) mice.	Polyphenols	129-140	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	112-115
29351230-3	2018	The present study was designed to compare the antioxidative effects of insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) on d-galactose-induced oxidation in Kunming (KM) mice.	Polyphenols	129-140	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	112-115
29061705-0	2018	Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice.	Polyphenols	0-10	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	51-54
29032047-11	2018	CONCLUSION: The studies provide new insights into the effect of pharmaceutical relevant polyphenols on salivary peroxidase activity and thus, suggest this enzyme as a new target for the prevention and therapy of oral inflammatory diseases.	Polyphenols	88-99	lactoperoxidase	Homo sapiens	103-122
28925872-9	2018	By their ability to restore endothelial function and also their capacity to stimulate enzymatic antioxidants through activation of the Keap1/Nrf2/ARE pathway, polyphenols can represent a promising treatment target for reducing human AAA progression.	Polyphenols	159-170	kelch like ECH associated protein 1	Homo sapiens	135-140
28925872-9	2018	By their ability to restore endothelial function and also their capacity to stimulate enzymatic antioxidants through activation of the Keap1/Nrf2/ARE pathway, polyphenols can represent a promising treatment target for reducing human AAA progression.	Polyphenols	159-170	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
29359608-0	2018	Tea polyphenols inhibit the proliferation, migration, and invasion of melanoma cells through the down-regulation of TLR4.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
29359608-0	2018	Tea polyphenols inhibit the proliferation, migration, and invasion of melanoma cells through the down-regulation of TLR4.	Polyphenols	4-15	toll-like receptor 4	Mus musculus	116-120
29359608-2	2018	Toll-like receptor 4 (TLR4) had been reported to play an important role in melanoma, and tea polyphenol (TP) is regarded as an anticancer substance.	Polyphenols	93-103	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	89-92
29358833-1	2018	In the present study, polyphenols from green tea (GTP), oolong tea (OTP) and black tea (BTP) were prepared by extraction with hot water and polyamide column chromatography.	Polyphenols	22-33	orthopedia homeobox	Homo sapiens	68-71
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Polyphenols	20-31	NFE2 like bZIP transcription factor 2	Homo sapiens	135-178
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Polyphenols	20-31	NFE2 like bZIP transcription factor 2	Homo sapiens	180-184
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Polyphenols	20-31	heme oxygenase 1	Homo sapiens	239-255
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Polyphenols	20-31	heme oxygenase 1	Homo sapiens	257-261
28643477-1	2018	Preclinical studies have suggested that polyphenols extracted from red wine (RWPs) favourably affect insulin sensitivity, but there is controversy over whether RWPs exert similar effects in humans.	Polyphenols	40-51	insulin	Homo sapiens	101-108
29157609-7	2017	Furthermore, the specific recognition ability of the MIPs for polyphenols, which was better than those of C18, C8, or non-molecularly imprinted polymer adsorbents, was successfully applied to the recognition of polyphenols in a Radix asteris sample.	Polyphenols	211-222	Bardet-Biedl syndrome 9	Homo sapiens	106-109
29258230-1	2017	The aim of this study was to determine the effect of polyphenol-rich ethanol extract of bee pollen (EEP) on atherosclerosis induced by a high-fat diet in ApoE-knockout mice.	Polyphenols	53-63	apolipoprotein E	Mus musculus	154-158
29242624-3	2017	SIRT1 activators, including plant polyphenols such as resveratrol, improve insulin sensitivity in skeletal muscle tissue.	Polyphenols	34-45	sirtuin 1	Rattus norvegicus	0-5
29090295-0	2017	Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain.	Polyphenols	30-41	neurotrophic receptor tyrosine kinase 2	Homo sapiens	110-114
29090295-0	2017	Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain.	Polyphenols	30-41	cAMP responsive element binding protein 1	Homo sapiens	115-119
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	Polyphenols	34-44	cAMP responsive element binding protein 1	Mus musculus	143-147
29090295-0	2017	Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain.	Polyphenols	30-41	brain derived neurotrophic factor	Homo sapiens	120-124
29090295-0	2017	Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain.	Polyphenols	30-41	kelch like ECH associated protein 1	Homo sapiens	137-142
29090295-0	2017	Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain.	Polyphenols	30-41	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
29312947-0	2017	Taheebo Polyphenols Attenuate Free Fatty Acid-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of Cyclooxygenase-2.	Polyphenols	8-19	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-141
29312947-6	2017	Some polyphenols have been reported for its selective inhibiting activity toward COX-2 expression.	Polyphenols	5-16	prostaglandin-endoperoxide synthase 2	Mus musculus	81-86
29031698-1	2017	Although some naturally occurring polyphenols have been found to inhibit amyloid beta (Abeta) fibril formation and reduce neuron cell toxicity in vitro, their exact inhibitory mechanism is unknown.	Polyphenols	34-45	amyloid beta precursor protein	Homo sapiens	87-92
29031698-10	2017	Our studies provide molecular-level insights into how polyphenols inhibit Abeta fibril formation, knowledge that could be useful for designing amyloid inhibitors.	Polyphenols	54-65	amyloid beta precursor protein	Homo sapiens	74-79
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	Polyphenols	34-44	brain derived neurotrophic factor	Mus musculus	148-152
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	Polyphenols	34-44	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	153-157
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	Polyphenols	34-44	thymoma viral proto-oncogene 1	Mus musculus	167-170
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	Polyphenols	34-44	mechanistic target of rapamycin kinase	Mus musculus	171-175
29195935-3	2017	After digestion, contents of polyphenol, polysaccharide and their antioxidant activity, the inhibitory activity of alpha-amylase and alpha-glucosidase significantly increased.	Polyphenols	29-39	sucrase-isomaltase	Homo sapiens	133-150
28970059-9	2017	These results suggest that oxidized forms of dietary polyphenols are the likely inducers of Hmox1 and may explain in part the protective cardiovascular effects of diets rich in these compounds.	Polyphenols	53-64	heme oxygenase 1	Mus musculus	92-97
28145414-5	2017	SUBJECTS/METHODS: We systematically searched Medline, EMBASE and the Cochrane database for all clinical trials assessing the effects of grape polyphenols on insulin sensitivity, glycemia, blood pressure or lipid levels.	Polyphenols	142-153	insulin	Homo sapiens	157-164
28145414-15	2017	Limited evidence suggests that grape polyphenols may improve insulin sensitivity.	Polyphenols	37-48	insulin	Homo sapiens	61-68
29061316-0	2017	Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1.	Polyphenols	4-15	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	130-135
29195935-6	2017	Lycopersicon esculentum Mill and Pyrus bretschneideri Rehd exhibited maximum increase in the inhibitory activity of alpha-glucosidase with lowest contents of polyphenols and polysaccharides.	Polyphenols	158-169	alpha-glucosidase	Pyrus x bretschneideri	116-133
28982342-4	2017	RESULTS: Polyphenols were able to reduce the increased release of interferon-gamma and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17.	Polyphenols	9-20	interferon gamma	Homo sapiens	66-82
29216948-0	2017	[Tea polyphenols down-regulate JNK phosphorylation to inhibit neuron apoptosis in rats with cardiac arrest].	Polyphenols	5-16	mitogen-activated protein kinase 8	Rattus norvegicus	31-34
29216948-1	2017	OBJECTIVE: To study the effect of tea polyphenols (TP) on c-Jun N-terminal kinase 1/2 (JNK1/2) phosphorylation and cell apoptosis in brain tissues in rats with cardiac arrest (CA) following cardiopulmonary resuscitation (CPR).	Polyphenols	38-49	mitogen-activated protein kinase 8	Rattus norvegicus	58-85
29551949-3	2017	The measured total polyphenol and flavonoid content of AHL was 184.24 +- 5.01 mg GAE/g and 102.53 +- 0.98 mg NAR/g.	Polyphenols	19-29	cadherin 23 (otocadherin)	Mus musculus	55-58
28982342-4	2017	RESULTS: Polyphenols were able to reduce the increased release of interferon-gamma and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17.	Polyphenols	9-20	interleukin 17A	Homo sapiens	159-164
28982342-4	2017	RESULTS: Polyphenols were able to reduce the increased release of interferon-gamma and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17.	Polyphenols	9-20	interleukin 4	Homo sapiens	87-105
28982342-4	2017	RESULTS: Polyphenols were able to reduce the increased release of interferon-gamma and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17.	Polyphenols	9-20	interleukin 10	Homo sapiens	149-154
29039788-8	2017	Here, we review the treatment of cancer cells with natural supplements (e.g., methyl donors, vitamins and polyphenols) that have been utilized to revert or prevent the epigenetic silencing of RASSF1A.	Polyphenols	106-117	Ras association domain family member 1	Homo sapiens	192-199
29329924-2	2017	Polyphenols could reduce oxidative stress and restore endothelial function by inhibiting the nicotinamide-adenine-dinucleotide-phosphate (NADPH) oxidase isoform Nox2.	Polyphenols	0-11	cytochrome b-245 beta chain	Homo sapiens	161-165
29329924-10	2017	CONCLUSIONS: Cocoa polyphenols improve endothelial function via Nox2 down-regulation in NASH patients.	Polyphenols	19-30	cytochrome b-245 beta chain	Homo sapiens	64-68
29112149-9	2017	This review analyzes the accumulated evidence of the antitumor effects of plant polyphenols on breast cancer, with special attention to their activity on ERs and HER2 targets and also covering different aspects such as redox balance, uncontrolled proliferation and chronic inflammation.	Polyphenols	80-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	162-166
29109097-5	2017	On the other hand, melting temperature profiles produced during PCR amplification run, found seven significant genes (miR-184, miR-203, miR-373, miR-124, miR-96, miR-373 and miR-301a), which separated candidate miRNAs that could function as novel molecular markers of relevance to oxidative stress and immunoglobulin function, for the intake of polyphenol (PP)-rich, functional fermented foods rich in lactobacilli (FS), or their combination.	Polyphenols	345-355	microRNA 184	Homo sapiens	118-125
29109097-5	2017	On the other hand, melting temperature profiles produced during PCR amplification run, found seven significant genes (miR-184, miR-203, miR-373, miR-124, miR-96, miR-373 and miR-301a), which separated candidate miRNAs that could function as novel molecular markers of relevance to oxidative stress and immunoglobulin function, for the intake of polyphenol (PP)-rich, functional fermented foods rich in lactobacilli (FS), or their combination.	Polyphenols	345-355	microRNA 203a	Homo sapiens	127-134
29109097-5	2017	On the other hand, melting temperature profiles produced during PCR amplification run, found seven significant genes (miR-184, miR-203, miR-373, miR-124, miR-96, miR-373 and miR-301a), which separated candidate miRNAs that could function as novel molecular markers of relevance to oxidative stress and immunoglobulin function, for the intake of polyphenol (PP)-rich, functional fermented foods rich in lactobacilli (FS), or their combination.	Polyphenols	345-355	microRNA 96	Homo sapiens	154-160
29163391-5	2017	After cultivation of 48 h, tea polyphenols, caffeine, and L-theanine decreased by 31.0, 26.2, and 8.3%, respectively.	Polyphenols	31-42	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	27-30
28898790-2	2017	The objective of this study was to investigate cytotoxicity and HIF-1alpha expression through the NF-kappaB pathway by polyphenol velutin (Euterpe oleracea Mart.	Polyphenols	119-129	hypoxia inducible factor 1, alpha subunit	Mus musculus	64-74
28551221-2	2017	Results showed that, with increasing extraction temperature, the polyphenol content increased, which contributed to enhance antioxidant activity and inhibitory effects on alpha-glucosidase and alpha-amylase.	Polyphenols	65-75	sucrase-isomaltase	Homo sapiens	171-188
28551262-1	2017	Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging.	Polyphenols	8-19	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	99-103
28551262-1	2017	Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging.	Polyphenols	8-18	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	99-103
28954885-0	2017	Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.	Polyphenols	10-20	toll interacting protein	Homo sapiens	38-44
28954885-0	2017	Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.	Polyphenols	10-20	E74 like ETS transcription factor 1	Homo sapiens	71-76
28886437-0	2017	Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women.	Polyphenols	23-33	insulin	Homo sapiens	77-84
28886437-9	2017	A dose response inhibition of glucose transport was demonstrated in Caco-2 cells, including total and GLUT-mediated transport, and SGLT1-mediated glucose transport was strongly inhibited at all doses in Xenopus oocytes, following 10 min incubation with 0.125-4 mg apple polyphenols/ml.	Polyphenols	270-281	solute carrier family 5 member 1	Homo sapiens	131-136
29068698-0	2017	The Impact of Dietary Polyphenols on COX-2 Expression in Colorectal Cancer.	Polyphenols	22-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	37-42
29068698-4	2017	Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid.	Polyphenols	0-11	interleukin 1 beta	Homo sapiens	112-120
29068698-4	2017	Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid.	Polyphenols	0-11	interleukin 6	Homo sapiens	122-126
29068698-4	2017	Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid.	Polyphenols	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
29068698-4	2017	Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid.	Polyphenols	0-11	tumor necrosis factor	Homo sapiens	138-147
29068698-4	2017	Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid.	Polyphenols	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	153-169
29068698-4	2017	Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid.	Polyphenols	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	171-176
29068698-5	2017	Furthermore, polyphenols exhibit anti-inflammatory activity on many levels via NF-kappaB inhibition, and MAPK, iNOS, and growth factors regulation.	Polyphenols	13-24	nitric oxide synthase 2	Homo sapiens	111-115
29068698-6	2017	This paper reviews the current state of knowledge concerning the potential of various dietary polyphenols to inhibit the effects of COX-2 in colon cancer, by examining the available evidence regarding the efficacy and safety of these compounds obtained from in vitro and animal studies.	Polyphenols	94-105	prostaglandin-endoperoxide synthase 2	Homo sapiens	132-137
29062069-3	2017	Here we show that resveratrol, a polyphenol, significantly induces PP2A activity and reduces Tau phosphorylation at PP2A-dependent epitopes.	Polyphenols	33-43	protein phosphatase 2 phosphatase activator	Homo sapiens	67-71
29062069-3	2017	Here we show that resveratrol, a polyphenol, significantly induces PP2A activity and reduces Tau phosphorylation at PP2A-dependent epitopes.	Polyphenols	33-43	microtubule associated protein tau	Homo sapiens	93-96
29062069-3	2017	Here we show that resveratrol, a polyphenol, significantly induces PP2A activity and reduces Tau phosphorylation at PP2A-dependent epitopes.	Polyphenols	33-43	protein phosphatase 2 phosphatase activator	Homo sapiens	116-120
29042482-1	2017	The polyphenol resveratrol activates the deacetylase Sirt1, resulting in various antioxidant, chemoprotectant, neuroprotective, cardioprotective, and anti-inflammatory properties.	Polyphenols	4-14	sirtuin 1	Homo sapiens	53-58
28539267-3	2017	In this study, we performed a computational docking experiment involving the pre-simulation of the binding mechanism of GT, and the effect of GT on alpha-glucosidase was evaluated with inhibitory kinetics based on its polyphenol properties.	Polyphenols	218-228	sucrase-isomaltase	Homo sapiens	148-165
29027934-8	2017	The results suggest that ACE-inhibition and antioxidant properties of FSPH-UF may be due to the bioactive peptides and polyphenols released during the enzymatic hydrolysis.	Polyphenols	119-130	angiotensin I converting enzyme	Homo sapiens	25-28
28591543-9	2017	Polyphenol supplementation did not significantly affect mobilization of dendritic cells but showed beneficial effects on regeneration of TLR7 expression in wbl at 3 days postmarathon (decline of 40% vs. increase of 1000%; p &lt; 0.05).	Polyphenols	0-10	toll like receptor 7	Homo sapiens	137-141
28591543-13	2017	However, polyphenols support regeneration of viral antigen presenting TLR7 after strenuous exercise.	Polyphenols	9-20	toll like receptor 7	Homo sapiens	70-74
28274719-3	2017	Making use of glutathionylated alkanals devoid of the 4 hydroxyl group, and thus unable to structurally arrange into a cyclic hemiacetal form, the susceptibility to inhibition of CBR1 to polyphenols was tested.	Polyphenols	187-198	carbonyl reductase 1	Homo sapiens	179-183
28490136-8	2017	Masking effect of polyphenol complexation on the antioxidative potential of the protein was of the similar degree for both glycated BLG and native BLG.	Polyphenols	18-28	beta-lactoglobulin	Bos taurus	132-135
28490136-8	2017	Masking effect of polyphenol complexation on the antioxidative potential of the protein was of the similar degree for both glycated BLG and native BLG.	Polyphenols	18-28	beta-lactoglobulin	Bos taurus	147-150
28941474-3	2017	show that tapinarof, a bacteria-derived polyphenol, is an aryl hydrocarbon receptor ligand that attenuated inflammatory responses and shows therapeutic potential for inflammatory skin diseases.	Polyphenols	40-50	aryl hydrocarbon receptor	Homo sapiens	58-83
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Polyphenols	300-311	p21 (RAC1) activated kinase 1	Mus musculus	68-72
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Polyphenols	300-311	midkine	Mus musculus	73-76
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Polyphenols	300-311	mitogen-activated protein kinase 1	Mus musculus	77-80
28523759-7	2017	The metabolizing enzyme responsible for sulfation of polyphenols is SULT1A1, and was found to be upregulated upon adipocyte differentiation.	Polyphenols	53-64	sulfotransferase family 1A member 1	Homo sapiens	68-75
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Polyphenols	300-311	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	81-86
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Polyphenols	300-311	MLX interacting protein-like	Mus musculus	181-187
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Polyphenols	300-311	MLX interacting protein-like	Mus musculus	252-258
28432554-3	2017	However, in the presence of epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, BEAS-2B cells resisted LPS-induced apoptosis and restored the expression of GRP and its downstream effectors such as epidermal growth factor receptor and NF-kappaB, as analysed by immunoblotting and qPCR.	Polyphenols	65-75	gastrin releasing peptide	Homo sapiens	166-169
28432554-3	2017	However, in the presence of epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, BEAS-2B cells resisted LPS-induced apoptosis and restored the expression of GRP and its downstream effectors such as epidermal growth factor receptor and NF-kappaB, as analysed by immunoblotting and qPCR.	Polyphenols	65-75	epidermal growth factor receptor	Homo sapiens	207-239
28432554-3	2017	However, in the presence of epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, BEAS-2B cells resisted LPS-induced apoptosis and restored the expression of GRP and its downstream effectors such as epidermal growth factor receptor and NF-kappaB, as analysed by immunoblotting and qPCR.	Polyphenols	65-75	nuclear factor kappa B subunit 1	Homo sapiens	244-253
28623808-0	2017	Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression.	Polyphenols	8-19	paraoxonase 1	Homo sapiens	67-71
28623808-0	2017	Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression.	Polyphenols	8-18	paraoxonase 1	Homo sapiens	67-71
28623808-2	2017	Several studies documented the capacity of polyphenols to stimulate PON1 transcription activation.	Polyphenols	43-54	paraoxonase 1	Homo sapiens	68-72
28623808-3	2017	The objective of the present review is to provide the main evidence about the role and the potential mechanism of action of polyphenols and polyphenol-rich foods in the modulation of PON1 gene expression and activity.	Polyphenols	124-135	paraoxonase 1	Homo sapiens	183-187
28623808-3	2017	The objective of the present review is to provide the main evidence about the role and the potential mechanism of action of polyphenols and polyphenol-rich foods in the modulation of PON1 gene expression and activity.	Polyphenols	124-134	paraoxonase 1	Homo sapiens	183-187
28623808-6	2017	Evidence from human studies is promising but deserves more substantiation about the role of polyphenol-rich foods in the regulation of PON1 activity and expression.	Polyphenols	92-102	paraoxonase 1	Homo sapiens	135-139
28623808-7	2017	Research focused on the understanding of the structure-activity relationship of polyphenols with PON1 and on the mechanisms at the base of PON1 modulation is warranted.	Polyphenols	80-91	paraoxonase 1	Homo sapiens	97-101
28618113-1	2017	SCOPE: This study aims to use a combination of biochemical and biophysical methods to derive greater mechanistic understanding of the interactions between tea polyphenols and porcine pancreatic alpha-amylase (PPA).	Polyphenols	159-170	amylase alpha 2A	Homo sapiens	183-207
28947831-2	2017	Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red wine, acts specifically through the human constitutive androstane receptor (CAR), a drug/xenobiotic detoxification gene regulator, to increase hepatic SHBG production.	Polyphenols	94-104	nuclear receptor subfamily 1 group I member 3	Homo sapiens	163-195
28840618-1	2017	We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD).	Polyphenols	23-33	sperm tail PG rich repeat containing 4	Mus musculus	82-85
28511887-0	2017	Antioxidant polyphenols in cancer treatment: Friend, foe or foil?	Polyphenols	12-23	WAPL cohesin release factor	Homo sapiens	53-56
28751004-8	2017	The translocation of GLUT4, phosphorylation of AMPK and the expression of SIRT1 and PGC-1alpha which were reduced in insulin resistant cells, were increased upon treatment with polyphenols.	Polyphenols	177-188	solute carrier family 2 member 4	Rattus norvegicus	21-26
28751004-8	2017	The translocation of GLUT4, phosphorylation of AMPK and the expression of SIRT1 and PGC-1alpha which were reduced in insulin resistant cells, were increased upon treatment with polyphenols.	Polyphenols	177-188	sirtuin 1	Rattus norvegicus	74-79
28751004-8	2017	The translocation of GLUT4, phosphorylation of AMPK and the expression of SIRT1 and PGC-1alpha which were reduced in insulin resistant cells, were increased upon treatment with polyphenols.	Polyphenols	177-188	PPARG coactivator 1 alpha	Rattus norvegicus	84-94
28947831-2	2017	Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red wine, acts specifically through the human constitutive androstane receptor (CAR), a drug/xenobiotic detoxification gene regulator, to increase hepatic SHBG production.	Polyphenols	94-104	nuclear receptor subfamily 1 group I member 3	Homo sapiens	197-200
27224877-3	2017	However, in this review we focus on the prebiotics properties in humans of the non-bioaccessible material of nuts (polymerized polyphenols and polysaccharides), which provides substrates for the human gut microbiota and on the formation of new bioactive metabolites and the absorption of that may partly explain the health benefits of nut consumption.	Polyphenols	127-138	NUT midline carcinoma family member 1	Homo sapiens	109-112
28738536-3	2017	The aim of the study is to investigate the impact of biologically active polyphenols such as apigenin, resveratrol and kaempferol on gene expression and protein secretion of IL-10 and TNF-alpha in line RAW-264.7.	Polyphenols	73-84	interleukin 10	Mus musculus	174-179
28796948-4	2017	Upon incubation with bovine serum albumin (BSA) under physiological conditions, several polyphenols converted the protein into the innate epitopes recognized by the IgM Abs.	Polyphenols	88-99	albumin	Homo sapiens	28-41
28478952-9	2017	In addition, the MELC was rich in polyphenol content and its GC-MS chromatogram confirmed the presence of some compounds all of which showed anticancer and cytotoxic activities in previous studies.	Polyphenols	34-44	melanocyte population size	Mus musculus	17-21
28924387-0	2017	Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol.	Polyphenols	138-148	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
28924387-3	2017	In current study, we conducted a series of experiments to clarify the effect of salvianolic acid A (SAA), a kind of polyphenol compound, in the process of EndMT in human pulmonary arterial endothelial cells and in vivo therapeutic efficacy on vascular remodeling in monocrotaline (MCT)-induced EndMT.	Polyphenols	116-126	serum amyloid A1 cluster	Homo sapiens	100-103
28738536-3	2017	The aim of the study is to investigate the impact of biologically active polyphenols such as apigenin, resveratrol and kaempferol on gene expression and protein secretion of IL-10 and TNF-alpha in line RAW-264.7.	Polyphenols	73-84	tumor necrosis factor	Mus musculus	184-193
28676325-0	2017	Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation.	Polyphenols	50-60	aryl hydrocarbon receptor	Homo sapiens	15-40
28676325-0	2017	Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation.	Polyphenols	50-60	aryl hydrocarbon receptor	Homo sapiens	42-45
28570943-1	2017	Dietary polyphenols have been shown to inhibit alpha-glucosidase, an enzyme target of some antidiabetic drugs.	Polyphenols	8-19	sucrase-isomaltase	Homo sapiens	47-64
29056865-7	2017	By exploring multiple facets of polyphenol-amyloid interactions, we provide a molecular basis for the opposing effects of PGG on full-length Abeta and its C-terminal fragments.	Polyphenols	32-42	amyloid beta precursor protein	Homo sapiens	141-146
28570943-2	2017	Resveratrol, a polyphenol found in grapes and wine, has been reported to inhibit the activity of yeast alpha-glucosidase.	Polyphenols	15-25	sucrase-isomaltase	Homo sapiens	103-120
29192437-6	2017	In this paper, the regulation effects of the main active substances of medicinal plants (such as polyphenols, saponins, and alkaloids) on p65 nuclear translocation and the upstream pathway of NF-kappaB were discussed, expecting to provide reference for the development of natural active substances for functional food.	Polyphenols	97-108	RELA proto-oncogene, NF-kB subunit	Homo sapiens	138-141
28317281-6	2017	In other mechanisms involved, the polyphenols except anthocyanins strongly prevented or reversed the effect on mitochondrial content/biogenesis, increased expression of manganese superoxide dismutase, and prevented the large increase in TNF-alpha expression.	Polyphenols	34-45	tumor necrosis factor	Homo sapiens	237-246
28317281-7	2017	Most polyphenols also prevented the decrease in uncoupling protein 2.	Polyphenols	5-16	uncoupling protein 2	Homo sapiens	48-68
28779377-0	2017	Combination of EPA with Carotenoids and Polyphenol Synergistically Attenuated the Transformation of Microglia to M1 Phenotype Via Inhibition of NF-kappaB.	Polyphenols	40-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-153
29192437-6	2017	In this paper, the regulation effects of the main active substances of medicinal plants (such as polyphenols, saponins, and alkaloids) on p65 nuclear translocation and the upstream pathway of NF-kappaB were discussed, expecting to provide reference for the development of natural active substances for functional food.	Polyphenols	97-108	nuclear factor kappa B subunit 1	Homo sapiens	192-201
28852023-1	2017	Novel soybean meal-based biomimetic (STP) adhesives were fabricated via soybean meal (SM) and enhanced by tannic acid (TA) and polyetheylenimine (PEI) (TAPI) co-crosslinking network based on natural polyphenol-inspired chemistry.	Polyphenols	199-209	sorbitol-like transporter	Glycine max	37-40
28533128-5	2017	B[a]P increased expression of genes related to oxidative stress and inflammation (Nrf2, UCP2, and TNF-alpha) after 24 h. Polyphenols strongly inhibited the increase in TNF-alpha and also several polyphenols inhibited the increase in UCP2.	Polyphenols	121-132	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-86
29088809-0	2017	Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-kappaB signaling pathway.	Polyphenols	55-66	microRNA 149	Homo sapiens	101-108
29088809-0	2017	Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-kappaB signaling pathway.	Polyphenols	55-66	AKT serine/threonine kinase 1	Homo sapiens	109-112
29088809-0	2017	Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-kappaB signaling pathway.	Polyphenols	55-66	nuclear factor kappa B subunit 1	Homo sapiens	113-122
28777810-0	2017	Green tea polyphenol treatment attenuates atherosclerosis in high-fat diet-fed apolipoprotein E-knockout mice via alleviating dyslipidemia and up-regulating autophagy.	Polyphenols	10-20	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
28777810-0	2017	Green tea polyphenol treatment attenuates atherosclerosis in high-fat diet-fed apolipoprotein E-knockout mice via alleviating dyslipidemia and up-regulating autophagy.	Polyphenols	10-20	apolipoprotein E	Mus musculus	79-95
28777810-1	2017	BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood.	Polyphenols	22-32	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	18-21
28777810-1	2017	BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood.	Polyphenols	22-32	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	73-76
28777810-1	2017	BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood.	Polyphenols	44-54	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	18-21
28777810-1	2017	BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood.	Polyphenols	44-54	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	73-76
28754329-0	2017	Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids.	Polyphenols	100-111	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	14-41
28754329-0	2017	Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids.	Polyphenols	100-111	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	43-46
28754329-4	2017	In this study, we investigated the inhibitory effects of various polyphenols and triterpenoids on the UGT-mediated GA 3-O-glucuronidation.	Polyphenols	65-76	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	102-105
28955792-2	2017	Here, we showed a plant polyphenol, kaempferol, attenuated IL-6-induced COX-2 expression in human monocytic THP-1 cells suggesting its beneficial role in chronic inflammation.	Polyphenols	24-34	interleukin 6	Homo sapiens	59-63
28817690-1	2017	BACKGROUND: Studies have demonstrated that resveratrol (a natural polyphenol) and caloric restriction activate Sirtuin-1 (SIRT1) and induce autophagy.	Polyphenols	66-76	sirtuin 1	Rattus norvegicus	111-120
28817690-1	2017	BACKGROUND: Studies have demonstrated that resveratrol (a natural polyphenol) and caloric restriction activate Sirtuin-1 (SIRT1) and induce autophagy.	Polyphenols	66-76	sirtuin 1	Rattus norvegicus	122-127
28533128-5	2017	B[a]P increased expression of genes related to oxidative stress and inflammation (Nrf2, UCP2, and TNF-alpha) after 24 h. Polyphenols strongly inhibited the increase in TNF-alpha and also several polyphenols inhibited the increase in UCP2.	Polyphenols	121-132	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	88-92
28533128-5	2017	B[a]P increased expression of genes related to oxidative stress and inflammation (Nrf2, UCP2, and TNF-alpha) after 24 h. Polyphenols strongly inhibited the increase in TNF-alpha and also several polyphenols inhibited the increase in UCP2.	Polyphenols	121-132	tumor necrosis factor	Mus musculus	98-107
28533128-5	2017	B[a]P increased expression of genes related to oxidative stress and inflammation (Nrf2, UCP2, and TNF-alpha) after 24 h. Polyphenols strongly inhibited the increase in TNF-alpha and also several polyphenols inhibited the increase in UCP2.	Polyphenols	121-132	tumor necrosis factor	Mus musculus	168-177
28533128-5	2017	B[a]P increased expression of genes related to oxidative stress and inflammation (Nrf2, UCP2, and TNF-alpha) after 24 h. Polyphenols strongly inhibited the increase in TNF-alpha and also several polyphenols inhibited the increase in UCP2.	Polyphenols	121-132	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	233-237
28718669-8	2017	We also showed fruit polyphenol-mediated release of mitochondrial pro- and antiapoptotic proteins of the Bcl-2 family and modulation activity of the Akt, p38 MAPK, and Erk 1/2 pathways as well as the signaling of ROS-mediated DNA damage.	Polyphenols	21-31	BCL2 apoptosis regulator	Homo sapiens	105-110
28264627-3	2017	In the present study, we found that all polyphenols (apigenin, fisetin, galangin and luteolin) bind to the hydrophobic groove of BCL-2 and the interaction is stable throughout MD simulation run.	Polyphenols	40-51	BCL2 apoptosis regulator	Homo sapiens	129-134
28264627-6	2017	Finally, on the basis of data obtained during the study, it can be concluded that these polyphenols have the potential to be used as lead molecules for BCL-2 inhibition.	Polyphenols	88-99	BCL2 apoptosis regulator	Homo sapiens	152-157
28718669-9	2017	Our data demonstrated that fruit peel polyphenols suppressed breast cancer cell growth through increased intracellular oxidative stress and the activation of p38 MAPK and de-activation of the Erk 1/2 and Akt signaling pathways.	Polyphenols	38-49	AKT serine/threonine kinase 1	Homo sapiens	204-207
28718669-8	2017	We also showed fruit polyphenol-mediated release of mitochondrial pro- and antiapoptotic proteins of the Bcl-2 family and modulation activity of the Akt, p38 MAPK, and Erk 1/2 pathways as well as the signaling of ROS-mediated DNA damage.	Polyphenols	21-31	AKT serine/threonine kinase 1	Homo sapiens	149-152
28718669-8	2017	We also showed fruit polyphenol-mediated release of mitochondrial pro- and antiapoptotic proteins of the Bcl-2 family and modulation activity of the Akt, p38 MAPK, and Erk 1/2 pathways as well as the signaling of ROS-mediated DNA damage.	Polyphenols	21-31	mitogen-activated protein kinase 1	Homo sapiens	154-157
28718669-8	2017	We also showed fruit polyphenol-mediated release of mitochondrial pro- and antiapoptotic proteins of the Bcl-2 family and modulation activity of the Akt, p38 MAPK, and Erk 1/2 pathways as well as the signaling of ROS-mediated DNA damage.	Polyphenols	21-31	mitogen-activated protein kinase 3	Homo sapiens	158-162
28718669-8	2017	We also showed fruit polyphenol-mediated release of mitochondrial pro- and antiapoptotic proteins of the Bcl-2 family and modulation activity of the Akt, p38 MAPK, and Erk 1/2 pathways as well as the signaling of ROS-mediated DNA damage.	Polyphenols	21-31	mitogen-activated protein kinase 3	Homo sapiens	168-175
28718669-9	2017	Our data demonstrated that fruit peel polyphenols suppressed breast cancer cell growth through increased intracellular oxidative stress and the activation of p38 MAPK and de-activation of the Erk 1/2 and Akt signaling pathways.	Polyphenols	38-49	mitogen-activated protein kinase 1	Homo sapiens	158-161
28718669-9	2017	Our data demonstrated that fruit peel polyphenols suppressed breast cancer cell growth through increased intracellular oxidative stress and the activation of p38 MAPK and de-activation of the Erk 1/2 and Akt signaling pathways.	Polyphenols	38-49	mitogen-activated protein kinase 3	Homo sapiens	192-199
27537110-3	2017	Natural polyphenols, and concretely Mangifera indica Linn extract (MGF), have been reported to have antiinflammatory, antioxidant and antidiabetic activities.	Polyphenols	8-19	kit ligand	Mus musculus	67-70
28478033-4	2017	Epigallocatechin-3-gallate (EGCG), the main polyphenol in green tea, inhibits Dyrk1a activity.	Polyphenols	44-54	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	78-84
28751752-0	2017	Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells.	Polyphenols	31-41	Kruppel-like factor 2 (lung)	Mus musculus	78-82
28894629-0	2017	Isolation, characterization and in silico docking studies of synergistic estrogen receptor a anticancer polyphenols from Syzygium alternifolium (Wt.)	Polyphenols	104-115	estrogen receptor 1	Homo sapiens	73-92
28754004-0	2017	Synergistic Interplay between Curcumin and Polyphenol-Rich Foods in the Mediterranean Diet: Therapeutic Prospects for Neurofibromatosis 1 Patients.	Polyphenols	43-53	neurofibromin 1	Homo sapiens	118-137
28754004-8	2017	We hypothesize that the combination of a polyphenol-rich Mediterranean diet and curcumin was responsible for the beneficial effect observed on NF1.	Polyphenols	41-51	neurofibromin 1	Homo sapiens	143-146
28214539-10	2017	A polyphenol-rich extract prepared from elderflower activated the Nrf2-mediated antioxidant response in cortical astrocytes, iPSC-derived astrocytes, and primary midbrain cultures, apparently via the inhibition of Nrf2 degradation mediated by the ubiquitin proteasome system.	Polyphenols	2-12	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
28214539-10	2017	A polyphenol-rich extract prepared from elderflower activated the Nrf2-mediated antioxidant response in cortical astrocytes, iPSC-derived astrocytes, and primary midbrain cultures, apparently via the inhibition of Nrf2 degradation mediated by the ubiquitin proteasome system.	Polyphenols	2-12	NFE2 like bZIP transcription factor 2	Homo sapiens	214-218
28235660-0	2017	Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.	Polyphenols	40-51	toll like receptor 4	Homo sapiens	14-18
28235660-6	2017	Polyphenols including flavonoids, phenolic acids, phenolic alcohols, stilbenes and lignans, can target TLR4 signaling pathways in multiple ways.	Polyphenols	0-11	toll like receptor 4	Homo sapiens	103-107
28235660-10	2017	Curcumin, another polyphenol, can suppress overexpression of inflammatory mediators via inhibiting the TLR4-MAPK/NF-kappaB pathway.	Polyphenols	18-28	toll like receptor 4	Homo sapiens	103-107
28235660-10	2017	Curcumin, another polyphenol, can suppress overexpression of inflammatory mediators via inhibiting the TLR4-MAPK/NF-kappaB pathway.	Polyphenols	18-28	nuclear factor kappa B subunit 1	Homo sapiens	113-122
28575427-0	2017	Corrigendum for "Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Fed Male Mice".	Polyphenols	22-32	fibroblast growth factor 21	Mus musculus	61-66
27206430-0	2017	Delayed Treatment with Green Tea Polyphenol EGCG Promotes Neurogenesis After Ischemic Stroke in Adult Mice.	Polyphenols	33-43	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	29-32
28665801-2	2017	In the regression we included the Ep1 of 12 polyphenols (mostly flavonols and catechins) that were measured in our laboratory at pH 3.	Polyphenols	44-55	prostaglandin E receptor 1	Homo sapiens	34-37
28670394-3	2017	Here we sought to investigate the effect and mechanism of pomegranate flower polyphenols (PFP) on NAFLD Apo E-/- mice induced by a high-fat diet (HFD) and whether PFP improves NAFLD through decreasing oxidative stress.	Polyphenols	77-88	apolipoprotein E	Mus musculus	104-109
28193435-0	2017	Effect of harvest time on some in vitro functional properties of hop polyphenols.	Polyphenols	69-80	HOP homeobox	Homo sapiens	65-68
28193435-1	2017	Health benefits of hop polyphenols are well studied.	Polyphenols	23-34	HOP homeobox	Homo sapiens	19-22
28638220-0	2017	Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats.	Polyphenols	10-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	88-92
28659745-8	2017	Interestingly, dietary tea polyphenols decreased the serum levels of pro-inflammatory factors (TNF-alpha: 13%, p &lt; 0.05; IL-1beta: 10%, p &lt; 0.05; and IL-6: 48%, p &lt; 0.05) and shifted the serum IL-10/TNF-alpha ratio to a predominantly anti-inflammatory milieu (0.52 +- 0.07 vs. 0.67 +- 0.10, p &lt; 0.01).	Polyphenols	27-38	tumor necrosis factor	Rattus norvegicus	95-104
28192862-9	2017	As a potential countermeasure, quercetin is a polyphenol possessing inherent anti-inflammatory and antioxidant effects that activate proliferator-activated gamma coactivator 1alpha (PGC-1alpha), increasing the abundance of mitochondrial biogenesis proteins.	Polyphenols	46-56	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	182-192
28659745-8	2017	Interestingly, dietary tea polyphenols decreased the serum levels of pro-inflammatory factors (TNF-alpha: 13%, p &lt; 0.05; IL-1beta: 10%, p &lt; 0.05; and IL-6: 48%, p &lt; 0.05) and shifted the serum IL-10/TNF-alpha ratio to a predominantly anti-inflammatory milieu (0.52 +- 0.07 vs. 0.67 +- 0.10, p &lt; 0.01).	Polyphenols	27-38	interleukin 1 beta	Rattus norvegicus	124-132
28659745-8	2017	Interestingly, dietary tea polyphenols decreased the serum levels of pro-inflammatory factors (TNF-alpha: 13%, p &lt; 0.05; IL-1beta: 10%, p &lt; 0.05; and IL-6: 48%, p &lt; 0.05) and shifted the serum IL-10/TNF-alpha ratio to a predominantly anti-inflammatory milieu (0.52 +- 0.07 vs. 0.67 +- 0.10, p &lt; 0.01).	Polyphenols	27-38	interleukin 6	Rattus norvegicus	156-160
28659745-8	2017	Interestingly, dietary tea polyphenols decreased the serum levels of pro-inflammatory factors (TNF-alpha: 13%, p &lt; 0.05; IL-1beta: 10%, p &lt; 0.05; and IL-6: 48%, p &lt; 0.05) and shifted the serum IL-10/TNF-alpha ratio to a predominantly anti-inflammatory milieu (0.52 +- 0.07 vs. 0.67 +- 0.10, p &lt; 0.01).	Polyphenols	27-38	interleukin 10	Rattus norvegicus	202-207
28659745-8	2017	Interestingly, dietary tea polyphenols decreased the serum levels of pro-inflammatory factors (TNF-alpha: 13%, p &lt; 0.05; IL-1beta: 10%, p &lt; 0.05; and IL-6: 48%, p &lt; 0.05) and shifted the serum IL-10/TNF-alpha ratio to a predominantly anti-inflammatory milieu (0.52 +- 0.07 vs. 0.67 +- 0.10, p &lt; 0.01).	Polyphenols	27-38	tumor necrosis factor	Rattus norvegicus	208-217
28659745-9	2017	Furthermore, the polyphenols effectively inhibited the release of tissue damage markers (CK: 24%, p &lt; 0.05 and LDH: 28%, p &lt; 0.05) in the serum and decreased IL-1beta mRNA expression in the liver.	Polyphenols	17-28	interleukin 1 beta	Rattus norvegicus	164-172
27896891-0	2017	STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma.	Polyphenols	19-30	signal transducer and activator of transcription 3	Homo sapiens	0-5
28556815-0	2017	The Antidiabetic Mechanisms of Polyphenols Related to Increased Glucagon-Like Peptide-1 (GLP1) and Insulin Signaling.	Polyphenols	31-42	glucagon	Homo sapiens	64-87
28556815-0	2017	The Antidiabetic Mechanisms of Polyphenols Related to Increased Glucagon-Like Peptide-1 (GLP1) and Insulin Signaling.	Polyphenols	31-42	glucagon	Homo sapiens	89-93
28556815-0	2017	The Antidiabetic Mechanisms of Polyphenols Related to Increased Glucagon-Like Peptide-1 (GLP1) and Insulin Signaling.	Polyphenols	31-42	insulin	Homo sapiens	99-106
28556815-5	2017	The present review describes the antidiabetic effects of polyphenols, specifically related to the secretion and effects of insulin and glucagon-like peptide 1 (GLP1), an enteric hormone that stimulates postprandial insulin secretion.	Polyphenols	57-68	insulin	Homo sapiens	123-130
28556815-5	2017	The present review describes the antidiabetic effects of polyphenols, specifically related to the secretion and effects of insulin and glucagon-like peptide 1 (GLP1), an enteric hormone that stimulates postprandial insulin secretion.	Polyphenols	57-68	glucagon	Homo sapiens	135-158
28556815-5	2017	The present review describes the antidiabetic effects of polyphenols, specifically related to the secretion and effects of insulin and glucagon-like peptide 1 (GLP1), an enteric hormone that stimulates postprandial insulin secretion.	Polyphenols	57-68	glucagon	Homo sapiens	160-164
28556815-5	2017	The present review describes the antidiabetic effects of polyphenols, specifically related to the secretion and effects of insulin and glucagon-like peptide 1 (GLP1), an enteric hormone that stimulates postprandial insulin secretion.	Polyphenols	57-68	insulin	Homo sapiens	215-222
28556815-6	2017	The evidence suggests that polyphenols from various sources stimulate L-cells to secrete GLP1, increase its half-life by inhibiting dipeptidyl peptidase-4 (DPP4), stimulate beta-cells to secrete insulin and stimulate the peripheral response to insulin, increasing the overall effects of the GLP1-insulin axis.	Polyphenols	27-38	glucagon	Homo sapiens	89-93
28556815-6	2017	The evidence suggests that polyphenols from various sources stimulate L-cells to secrete GLP1, increase its half-life by inhibiting dipeptidyl peptidase-4 (DPP4), stimulate beta-cells to secrete insulin and stimulate the peripheral response to insulin, increasing the overall effects of the GLP1-insulin axis.	Polyphenols	27-38	dipeptidyl peptidase 4	Homo sapiens	132-154
28556815-6	2017	The evidence suggests that polyphenols from various sources stimulate L-cells to secrete GLP1, increase its half-life by inhibiting dipeptidyl peptidase-4 (DPP4), stimulate beta-cells to secrete insulin and stimulate the peripheral response to insulin, increasing the overall effects of the GLP1-insulin axis.	Polyphenols	27-38	dipeptidyl peptidase 4	Homo sapiens	156-160
28556815-6	2017	The evidence suggests that polyphenols from various sources stimulate L-cells to secrete GLP1, increase its half-life by inhibiting dipeptidyl peptidase-4 (DPP4), stimulate beta-cells to secrete insulin and stimulate the peripheral response to insulin, increasing the overall effects of the GLP1-insulin axis.	Polyphenols	27-38	insulin	Homo sapiens	195-202
28556815-6	2017	The evidence suggests that polyphenols from various sources stimulate L-cells to secrete GLP1, increase its half-life by inhibiting dipeptidyl peptidase-4 (DPP4), stimulate beta-cells to secrete insulin and stimulate the peripheral response to insulin, increasing the overall effects of the GLP1-insulin axis.	Polyphenols	27-38	insulin	Homo sapiens	244-251
28470323-2	2017	Inhibition of alpha-amylase and alpha-glucosidase enzymes using natural products (especially polyphenols) is a novel oral policy to regulate carbohydrate metabolism and hyperglycemia.	Polyphenols	93-104	sucrase-isomaltase	Homo sapiens	32-49
28470323-3	2017	The present study aims to evaluate the alpha-amylase and alpha-glucosidase inhibitory activity of 26 polyphenols using molecular docking and virtual screening studies.	Polyphenols	101-112	sucrase-isomaltase	Homo sapiens	57-74
28470323-6	2017	Therefore the primary structure of polyphenols can change the inhibitory effect versus the alpha-amylase and alpha-glucosidase enzymes.	Polyphenols	35-46	sucrase-isomaltase	Homo sapiens	109-126
28238838-0	2017	Polyphenols in combination with beta-cyclodextrin can inhibit and disaggregate alpha-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative.	Polyphenols	0-11	synuclein, alpha	Mus musculus	79-94
28238838-2	2017	In this study we have examined the effects of four naturally occurring polyphenols in combination with beta-cyclodextrin (beta-CD) on the aggregation of alpha-synuclein in the presence of macromolecular crowding agents.	Polyphenols	71-82	synuclein, alpha	Mus musculus	153-168
28238838-3	2017	Our results reveal that even at sub-stoichiometric concentrations of the individual components, the polyphenol-beta-CD combination(s) not only inhibited the aggregation of the proteins but was also effective in disaggregating preformed fibrils.	Polyphenols	100-110	adrenocortical dysplasia	Mus musculus	111-118
28238838-9	2017	MTT assays on cell viability independently confirmed this hypothesis wherein these combinations (and the polyphenols alone too) appreciably impeded the toxicity of the prefibrillar alpha-synuclein aggregates on the mouse neuroblastoma cell lines (N2a cells).	Polyphenols	105-116	synuclein, alpha	Mus musculus	181-196
27896891-9	2017	An understanding of targeting STAT3 by PPs brings an opportunity to melanoma therapy.	Polyphenols	39-42	signal transducer and activator of transcription 3	Homo sapiens	30-35
28339032-0	2017	ClC-7/Ostm1 contribute to the ability of tea polyphenols to maintain bone homeostasis in C57BL/6 mice, protecting against fluorosis.	Polyphenols	45-56	chloride channel, voltage-sensitive 7	Mus musculus	0-5
28279696-1	2017	Natural polyphenol resveratrol (trihydroxystilbene) is a partial agonist of human aryl hydrocarbon receptor AhR, thereby, displaying a plethora of biological effects.	Polyphenols	8-18	aryl hydrocarbon receptor	Homo sapiens	82-107
28279696-1	2017	Natural polyphenol resveratrol (trihydroxystilbene) is a partial agonist of human aryl hydrocarbon receptor AhR, thereby, displaying a plethora of biological effects.	Polyphenols	8-18	aryl hydrocarbon receptor	Homo sapiens	108-111
28339032-0	2017	ClC-7/Ostm1 contribute to the ability of tea polyphenols to maintain bone homeostasis in C57BL/6 mice, protecting against fluorosis.	Polyphenols	45-56	osteopetrosis associated transmembrane protein 1	Mus musculus	6-11
28287659-0	2017	Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor.	Polyphenols	40-51	aryl hydrocarbon receptor	Homo sapiens	73-98
28102474-1	2017	Recently, combination therapy involving cholinesterase (ChE) inhibitor with other neuroprotective agents has shown better desirable effect in the management/prevention of dementia but limited information is available on their effect with dietary polyphenols.	Polyphenols	246-257	butyrylcholinesterase	Rattus norvegicus	56-59
28282584-9	2017	These results suggest that pomegranate polyphenols attenuated DSS-induced colitis by modulating the miR-145/p70S6K/HIF1alpha axis, indicating potential use in therapeutic treatment of ulcerative colitis.	Polyphenols	39-50	microRNA 145	Homo sapiens	100-107
28386616-2	2017	Hydroxytyrosol (HT), a polyphenol with cytoprotective effects present in extra virgin olive oil, improves the cellular antioxidant capacity for activation of transcription factor Nrf2.	Polyphenols	23-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	179-183
28287659-2	2017	Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake.	Polyphenols	86-97	aryl hydrocarbon receptor	Homo sapiens	44-47
28287659-2	2017	Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake.	Polyphenols	86-97	aryl hydrocarbon receptor	Homo sapiens	133-136
28287659-2	2017	Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake.	Polyphenols	86-97	aryl hydrocarbon receptor	Homo sapiens	279-282
28287659-2	2017	Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake.	Polyphenols	86-96	aryl hydrocarbon receptor	Homo sapiens	44-47
28287659-2	2017	Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake.	Polyphenols	86-96	aryl hydrocarbon receptor	Homo sapiens	133-136
28287659-2	2017	Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake.	Polyphenols	216-226	aryl hydrocarbon receptor	Homo sapiens	44-47
28287659-2	2017	Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake.	Polyphenols	216-226	aryl hydrocarbon receptor	Homo sapiens	133-136
28287659-4	2017	Furthermore, we made a brief mechanistic synopsis of the pharmacological/therapeutic use of polyphenols as AhR antagonists, selective AhR regulators and dual AhR/ER modulators, and underscored their potential in the prevention/treatment of common human diseases/disorders.	Polyphenols	92-103	aryl hydrocarbon receptor	Homo sapiens	107-110
28287659-4	2017	Furthermore, we made a brief mechanistic synopsis of the pharmacological/therapeutic use of polyphenols as AhR antagonists, selective AhR regulators and dual AhR/ER modulators, and underscored their potential in the prevention/treatment of common human diseases/disorders.	Polyphenols	92-103	aryl hydrocarbon receptor	Homo sapiens	134-137
28287659-4	2017	Furthermore, we made a brief mechanistic synopsis of the pharmacological/therapeutic use of polyphenols as AhR antagonists, selective AhR regulators and dual AhR/ER modulators, and underscored their potential in the prevention/treatment of common human diseases/disorders.	Polyphenols	92-103	aryl hydrocarbon receptor	Homo sapiens	134-137
28294257-7	2017	In an allergen model system, RBL-2H3 mast cells were exposed to peanut protein-polyphenol complexes and evaluated for their inhibitory activity on ionomycin-induced degranulation (beta-hexosaminidase and histamine).	Polyphenols	79-89	O-GlcNAcase	Rattus norvegicus	180-199
27979205-2	2017	A Kinetex C18 reversed-phase column was proposed under gradient elution for the determination of 17 polyphenols.	Polyphenols	100-111	Bardet-Biedl syndrome 9	Homo sapiens	10-13
28539729-0	2017	Anti-Fatigue Effect of Green Tea Polyphenols (-)-Epigallocatechin-3-Gallate (EGCG).	Polyphenols	33-44	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	29-32
27921359-9	2017	These findings were accompanied by tissue and plasma reduced expression levels of VEGF-B and its receptors, VEGFR1 and neuropilin-1, by both polyphenols.	Polyphenols	141-152	vascular endothelial growth factor B	Mus musculus	82-88
27921359-9	2017	These findings were accompanied by tissue and plasma reduced expression levels of VEGF-B and its receptors, VEGFR1 and neuropilin-1, by both polyphenols.	Polyphenols	141-152	FMS-like tyrosine kinase 1	Mus musculus	108-114
27921359-9	2017	These findings were accompanied by tissue and plasma reduced expression levels of VEGF-B and its receptors, VEGFR1 and neuropilin-1, by both polyphenols.	Polyphenols	141-152	neuropilin 1	Mus musculus	119-131
27921359-11	2017	We also show for the first time that both polyphenols decreased VEGF-B pathway, which is implicated in endothelial-to-tissue lipid metabolism.	Polyphenols	42-53	vascular endothelial growth factor B	Mus musculus	64-70
28539729-1	2017	BACKGROUND: (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant of the green tea polyphenols that exhibit a variety of bioactivities.	Polyphenols	88-99	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	84-87
28115221-1	2017	In previous studies, we showed that a high-dose intake of green tea polyphenol (GP) induced a hepatospecific decrease in the expression and activity of the drug-metabolizing enzyme cytochrome P450 3A (CYP3A).	Polyphenols	68-78	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	181-199
27951496-4	2017	Caffeic acid, a non-toxic polyphenol which is abundant in many foods modulates glutathione S-transferase (GST) and glutathione reductase (GSR) activity, these enzymes were shown to be involved in resistance of cells towards cisplatin.	Polyphenols	26-36	glutathione-disulfide reductase	Homo sapiens	115-136
27662903-8	2017	Finally, simvastatin and the polyphenol quercetin potentiated the antiproliferative effect of insulin; on the contrary, the polyphenol resveratrol, the polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids, and folic acid were not able to change it.	Polyphenols	29-39	insulin	Homo sapiens	94-101
28115221-1	2017	In previous studies, we showed that a high-dose intake of green tea polyphenol (GP) induced a hepatospecific decrease in the expression and activity of the drug-metabolizing enzyme cytochrome P450 3A (CYP3A).	Polyphenols	68-78	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	201-206
25746842-7	2017	Combining all subjects (n = 1954, mean baseline HbA1c = 7.03%, 53 mmol/mol), polyphenol supplementation significantly (P &lt; 0.001) lowered HbA1c% by -0.53 +- 0.12 units (-5.79 +- 0.13 mmol/mol).	Polyphenols	77-87	hemoglobin subunit alpha 1	Homo sapiens	48-52
28218703-5	2017	The anti-inflammatory (tumor necrosis factor-alpha [TNF-alpha] and interleukin-6 [IL-6]) activities of the polyphenol fractions of the blueberries were investigated by using lipopolysaccharide (LPS) induced RAW 264.7 macrophages.	Polyphenols	107-117	tumor necrosis factor	Homo sapiens	23-50
28213107-3	2017	This study was designed to address this issue by studying the polyphenols enriched extract (RPE) of Rosa rugosa Thunb in diabetic rats.	Polyphenols	62-73	ribulose-5-phosphate-3-epimerase	Rattus norvegicus	92-95
27905107-2	2017	Dietary polyphenols such as proanthocyanidins (PAC) may reduce inflammation, and we therefore hypothesized that PAC may suppress lipopolysaccharide (LPS) -induced responses in human DCs and subsequent T helper type 1 (Th1) -type responses in naive T cells.	Polyphenols	8-19	negative elongation factor complex member C/D	Homo sapiens	201-221
29624273-4	2017	Both pro-oxidant activity of polyphenols at high concentrations and their ability to decrease efflux function of P-gp (cellular multidrug resistance protein) could be exploited for improving anticancer adjuvant therapy.	Polyphenols	29-40	glycerol-3-phosphate phosphatase	Cricetulus griseus	113-117
28128384-0	2017	Mung bean (Phaseolus radiatus L.) polyphenol extract attenuates aluminum-induced cardiotoxicity through an ROS-triggered Ca2+/JNK/NF-kappaB signaling pathway in rats.	Polyphenols	34-44	mitogen-activated protein kinase 8	Rattus norvegicus	126-129
28218703-5	2017	The anti-inflammatory (tumor necrosis factor-alpha [TNF-alpha] and interleukin-6 [IL-6]) activities of the polyphenol fractions of the blueberries were investigated by using lipopolysaccharide (LPS) induced RAW 264.7 macrophages.	Polyphenols	107-117	interleukin 6	Homo sapiens	67-80
28218703-5	2017	The anti-inflammatory (tumor necrosis factor-alpha [TNF-alpha] and interleukin-6 [IL-6]) activities of the polyphenol fractions of the blueberries were investigated by using lipopolysaccharide (LPS) induced RAW 264.7 macrophages.	Polyphenols	107-117	interleukin 6	Homo sapiens	82-86
28218703-7	2017	Although the polyphenol-enriched fractions of blueberries could inhibit the microRNAs (miRNAs) (miR-21, miR-146a, and miR-125b) to different extents, no significant contribution from the PAs was observed.	Polyphenols	13-23	microRNA 21	Homo sapiens	96-102
28218703-7	2017	Although the polyphenol-enriched fractions of blueberries could inhibit the microRNAs (miRNAs) (miR-21, miR-146a, and miR-125b) to different extents, no significant contribution from the PAs was observed.	Polyphenols	13-23	microRNA 146a	Homo sapiens	104-112
27852009-8	2017	To date, many epigenetically active natural substances (such as polyphenols and flavonoids) and synthetic compounds such as DNMT inhibitors or HDAC inhibitors are known.	Polyphenols	64-75	DNA methyltransferase 1	Homo sapiens	124-128
28192456-1	2017	Flavanoids and related polyphenols, among them hesperitin, have been shown to modulate cellular glucose transport by targeting SGLT-1 and GLUT-2 transport proteins.	Polyphenols	23-34	solute carrier family 2 member 1	Homo sapiens	138-142
28290272-0	2017	Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial.	Polyphenols	25-36	insulin	Homo sapiens	45-52
28290272-0	2017	Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial.	Polyphenols	25-36	insulin	Homo sapiens	68-75
28290272-9	2017	A 6-week dietary intervention with 333 mg of polyphenols from strawberries and cranberries improved insulin sensitivity in overweight and obese non-diabetic, insulin-resistant human subjects but was not effective in improving other cardiometabolic risk factors.	Polyphenols	45-56	insulin	Homo sapiens	100-107
28290272-9	2017	A 6-week dietary intervention with 333 mg of polyphenols from strawberries and cranberries improved insulin sensitivity in overweight and obese non-diabetic, insulin-resistant human subjects but was not effective in improving other cardiometabolic risk factors.	Polyphenols	45-56	insulin	Homo sapiens	158-165
27967217-0	2017	Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.	Polyphenols	5-15	fibroblast growth factor 21	Mus musculus	44-49
28049293-2	2017	We applied solution small-angle X-ray scattering (SAXS) to study the complex structure of bovine serum albumin (BSA) and trypsin binding with tea polyphenols, that is, catechin and epigallocatechin gallate (EGCG).	Polyphenols	146-157	albumin	Homo sapiens	97-116
27888116-0	2017	HPV16 induces a wasting syndrome in transgenic mice: Amelioration by dietary polyphenols via NF-kappaB inhibition.	Polyphenols	77-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-102
28230758-3	2017	In addition, the principal polyphenols (1, 2, 8, 13-15) exhibited hepatoprotective effects against d-galactosamine (d-galN)/lipopolysaccharide (LPS)-induced liver injury in mice at a dose of 100 or 200 mg/kg, p.o.	Polyphenols	27-38	galanin and GMAP prepropeptide	Mus musculus	118-122
28230758-5	2017	The mechanisms of action of these polyphenols (1, 2, and 8) were suggested to be dependent on the inhibition of LPS-induced macrophage activation and reduction of sensitivity of hepatocytes to TNF-alpha.	Polyphenols	34-45	tumor necrosis factor	Mus musculus	193-202
28192456-1	2017	Flavanoids and related polyphenols, among them hesperitin, have been shown to modulate cellular glucose transport by targeting SGLT-1 and GLUT-2 transport proteins.	Polyphenols	23-34	solute carrier family 5 member 1	Homo sapiens	127-133
28079202-0	2017	Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor.	Polyphenols	28-38	ribosomal protein SA	Homo sapiens	70-93
28079202-1	2017	Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR).	Polyphenols	10-20	ribosomal protein SA	Homo sapiens	136-159
28079202-1	2017	Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR).	Polyphenols	10-20	ribosomal protein SA	Homo sapiens	161-165
27826992-5	2017	Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens.	Polyphenols	87-98	catechol-O-methyltransferase	Homo sapiens	193-197
27826992-5	2017	Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens.	Polyphenols	87-98	catechol-O-methyltransferase	Homo sapiens	307-311
27561918-1	2017	SCOPE: The present study was developed to determine the ability of polyphenol-rich black carrot and its by-products, i.e., peel and pomace, to modulate the inflammatory response in tumor necrosis factor alpha (TNF-alpha) treated endothelial cells after gastrointestinal digestion and in a co-culture of intestinal Caco-2 and endothelial EA.hy926 cell model.	Polyphenols	67-77	tumor necrosis factor	Homo sapiens	181-208
27561918-3	2017	The transported polyphenols were able to downregulate the secretion of pro-inflammatory markers, i.e. IL-8, monocyte chemoattractant protein 1, vascular endothelial growth factor, and intercellular adhesion molecule 1, under normal and tumor necrosis factor alpha induced inflammatory conditions.	Polyphenols	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
27561918-3	2017	The transported polyphenols were able to downregulate the secretion of pro-inflammatory markers, i.e. IL-8, monocyte chemoattractant protein 1, vascular endothelial growth factor, and intercellular adhesion molecule 1, under normal and tumor necrosis factor alpha induced inflammatory conditions.	Polyphenols	16-27	C-C motif chemokine ligand 2	Homo sapiens	108-142
27561918-3	2017	The transported polyphenols were able to downregulate the secretion of pro-inflammatory markers, i.e. IL-8, monocyte chemoattractant protein 1, vascular endothelial growth factor, and intercellular adhesion molecule 1, under normal and tumor necrosis factor alpha induced inflammatory conditions.	Polyphenols	16-27	vascular endothelial growth factor A	Homo sapiens	144-217
27561918-3	2017	The transported polyphenols were able to downregulate the secretion of pro-inflammatory markers, i.e. IL-8, monocyte chemoattractant protein 1, vascular endothelial growth factor, and intercellular adhesion molecule 1, under normal and tumor necrosis factor alpha induced inflammatory conditions.	Polyphenols	16-27	tumor necrosis factor	Homo sapiens	236-263
27974694-0	2017	Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells.	Polyphenols	21-31	C-X-C motif chemokine receptor 4	Homo sapiens	55-60
27974694-0	2017	Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells.	Polyphenols	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-70
28261618-1	2017	Resveratrol is a polyphenol that presents both antineuroinflammatory properties and the ability to interact with NOS-3, what contributes to vasorelaxation.	Polyphenols	17-27	nitric oxide synthase 3	Rattus norvegicus	113-118
28119607-0	2016	Estrogen Receptor alpha Participates to the Beneficial Effect of Red Wine Polyphenols in a Mouse Model of Obesity-Related Disorders.	Polyphenols	74-85	estrogen receptor 1 (alpha)	Mus musculus	0-23
28119607-2	2016	Previously, we demonstrated that the alpha isoform of estrogen receptor (ERalpha) triggers the vascular protection of polyphenols.	Polyphenols	118-129	estrogen receptor 1 (alpha)	Mus musculus	73-80
28119607-10	2016	ERalpha deletion prevented or reduced the beneficial effects of polyphenols, especially visceral adiposity, aortic and liver oxidative stresses and NO  bioavailability.	Polyphenols	64-75	estrogen receptor 1 (alpha)	Mus musculus	0-7
28119607-13	2016	Dietary supplementation of polyphenols remarkably attenuates features of metabolic syndrome; these effects are partially mediated by ERalpha-dependent mechanisms.	Polyphenols	27-38	estrogen receptor 1 (alpha)	Mus musculus	133-140
28243360-7	2017	Polyphenols significantly increased IL-10 release from H donors, whereas a trend to increase was observed in Ob people.	Polyphenols	0-11	interleukin 10	Homo sapiens	36-41
28707594-6	2017	Instead, this metal dramatically reduced production of IL-17 which was restored by the supplementation of polyphenols.	Polyphenols	106-117	interleukin 17A	Homo sapiens	55-60
28660008-7	2017	The selective COX-2 inhibitor, NS398, reduced to the same extent vasoconstriction in aortas from ZF and Provinols-treated ZF rats.	Polyphenols	104-113	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	14-19
29227717-3	2017	Quercetin is a polyphenol that has been reported to be an active oxygen scavenger as well as a functional adenosine monophosphate-activated protein kinase (AMPK) activator.	Polyphenols	15-25	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	106-154
29227717-3	2017	Quercetin is a polyphenol that has been reported to be an active oxygen scavenger as well as a functional adenosine monophosphate-activated protein kinase (AMPK) activator.	Polyphenols	15-25	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	156-160
28243360-8	2017	In addition, polyphenols were able to significantly increase levels of H IL-21, while this was not the case in Ob people.	Polyphenols	13-24	interleukin 21	Homo sapiens	73-78
28904737-2	2017	Based on the advantage of polyphenol on diabetic eye complications, we hypothesized that the combined extract of mango seed Vietnamese coriander (MPO), a polyphenol-rich substance, should possess anticataractogenesis and antiretinopathy in streptozotocin- (STZ-) diabetic rats.	Polyphenols	26-36	myeloperoxidase	Rattus norvegicus	146-149
28904737-2	2017	Based on the advantage of polyphenol on diabetic eye complications, we hypothesized that the combined extract of mango seed Vietnamese coriander (MPO), a polyphenol-rich substance, should possess anticataractogenesis and antiretinopathy in streptozotocin- (STZ-) diabetic rats.	Polyphenols	154-164	myeloperoxidase	Rattus norvegicus	146-149
28456872-1	2017	Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols.	Polyphenols	205-216	catechol-O-methyltransferase	Homo sapiens	0-28
28456872-1	2017	Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols.	Polyphenols	205-216	catechol-O-methyltransferase	Homo sapiens	30-34
27981846-5	2016	Forty-three polyphenols (cinnamic acid, cinnamoyl-amide, 5 cinammoyl-glycosides, and 36 cinnamate esters) were identified using LC-MSn.	Polyphenols	12-23	moesin	Homo sapiens	131-134
28814987-0	2017	Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High-Fat Diet via Ketogenesis/SIRT3 Pathway.	Polyphenols	10-21	sirtuin 3	Rattus norvegicus	99-104
29230268-0	2017	An Alginate/Cyclodextrin Spray Drying Matrix to Improve Shelf Life and Antioxidant Efficiency of a Blood Orange By-Product Extract Rich in Polyphenols: MMPs Inhibition and Antiglycation Activity in Dysmetabolic Diseases.	Polyphenols	139-150	matrix metallopeptidase 2	Homo sapiens	152-156
28243360-9	2017	Since IL-21 is an inducer of Th17 cells, it is likely that polyphenols may suppress the sources of this cytokine via production of IL-10.	Polyphenols	59-70	interleukin 21	Homo sapiens	6-11
28243360-9	2017	Since IL-21 is an inducer of Th17 cells, it is likely that polyphenols may suppress the sources of this cytokine via production of IL-10.	Polyphenols	59-70	interleukin 10	Homo sapiens	131-136
28243360-10	2017	Accordingly, polyphenols decreased IL-1beta and IL-6 release in comparison to H controls.	Polyphenols	13-24	interleukin 1 beta	Homo sapiens	35-43
28243360-10	2017	Accordingly, polyphenols decreased IL-1beta and IL-6 release in comparison to H controls.	Polyphenols	13-24	interleukin 6	Homo sapiens	48-52
27999314-5	2016	Most natural polyphenols are thought to impair breast cancer metastasis through downregulation of MMPs expression, interference with the VEGF signaling pathway, modulation of EMT regulator, inhibition of NF-kappaB and mTOR expression, and other related mechanisms.	Polyphenols	13-24	IL2 inducible T cell kinase	Homo sapiens	175-178
28066771-3	2016	This study was designed to evaluate the modulation of dietary tea polyphenols (TPs) on intestinal Bifidobacteria (IB) and its correlation with AS development in apolipoprotein E-deficient (ApoE-/-) mice.	Polyphenols	66-77	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	62-65
28006924-6	2016	Recently, we have revealed that resveratrol and other natural polyphenols attenuate D-GalN/LPS-induced hepatitis.	Polyphenols	62-73	galanin and GMAP prepropeptide	Rattus norvegicus	86-90
27989132-5	2016	Many dietary phytochemicals with cancer chemopreventive properties, such as polyphenols, isothiocyanates, and triterpenoids, exert antioxidant and anti-inflammatory functions by activating the Nrf2 pathway.	Polyphenols	76-87	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
27999314-5	2016	Most natural polyphenols are thought to impair breast cancer metastasis through downregulation of MMPs expression, interference with the VEGF signaling pathway, modulation of EMT regulator, inhibition of NF-kappaB and mTOR expression, and other related mechanisms.	Polyphenols	13-24	mechanistic target of rapamycin kinase	Homo sapiens	218-222
27750207-0	2016	Free radical scavenging and COX-2 inhibition by simple colon metabolites of polyphenols: A theoretical approach.	Polyphenols	76-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	28-33
27845788-8	2016	The PPARgamma protein, ABCA1 protein and CYP7A1 protein were up-regulated in L-02 cells treated with the three tested polyphenols.	Polyphenols	118-129	peroxisome proliferator activated receptor gamma	Homo sapiens	4-13
27845788-8	2016	The PPARgamma protein, ABCA1 protein and CYP7A1 protein were up-regulated in L-02 cells treated with the three tested polyphenols.	Polyphenols	118-129	ATP binding cassette subfamily A member 1	Homo sapiens	23-28
27845788-8	2016	The PPARgamma protein, ABCA1 protein and CYP7A1 protein were up-regulated in L-02 cells treated with the three tested polyphenols.	Polyphenols	118-129	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	41-47
27696504-0	2016	Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster.	Polyphenols	10-21	mitoferrin	Drosophila melanogaster	66-76
27750207-1	2016	Free radical scavenging and inhibitory potency against cyclooxygenase-2 (COX-2) by two abundant colon metabolites of polyphenols, i.e., 3-hydroxyphenylacetic acid (3-HPAA) and 4-hydroxyphenylpropionic acid (4-HPPA) were theoretically studied.	Polyphenols	117-128	prostaglandin-endoperoxide synthase 2	Homo sapiens	55-71
27750207-1	2016	Free radical scavenging and inhibitory potency against cyclooxygenase-2 (COX-2) by two abundant colon metabolites of polyphenols, i.e., 3-hydroxyphenylacetic acid (3-HPAA) and 4-hydroxyphenylpropionic acid (4-HPPA) were theoretically studied.	Polyphenols	117-128	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-78
28039406-13	2016	Polyphenol supplementation may attenuate the IL-8 response, however, did not affect granulocyte percentage and adhesion molecule expression in peripheral blood following resistance exercise.	Polyphenols	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
27750207-6	2016	Shown free radical scavenging potency of 3-HPAA and 4-HPPA along with their high muM concentration produced by microbial colon degradation of polyphenols could enable at least in situ inactivation of free radicals.	Polyphenols	142-153	latexin	Homo sapiens	81-84
27889107-1	2016	We recently demonstrated that California table grapes and a methanol-extractable, polyphenol-rich fraction decreased adiposity, insulin resistance, or markers of inflammation in high-fat fed mice.	Polyphenols	82-92	insulin	Homo sapiens	128-135
27846985-8	2016	Using Partial Least Squares (PLS-1) analysis, excellent correlations have been found between the responses provided by the array of biosensors and classical parameters directly related to phenols (total polyphenol index, TPI) and sugar concentration (degree Brix) measured by chemical methods with correlation coefficients close to 1 and errors close to 0.	Polyphenols	203-213	plastin 1	Homo sapiens	29-34
26811344-0	2016	Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice.	Polyphenols	43-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
27213823-0	2016	Polyphenols from Silybum marianum inhibit in vitro the oxidant response of equine neutrophils and myeloperoxidase activity.	Polyphenols	0-11	myeloperoxidase	Equus caballus	98-113
29450132-0	2016	Green tea polyphenols affect invasiveness of human gastric MKN-28 cells by inhibition of LPS or TNF-alpha induced Matrix Metalloproteinase-9/2.	Polyphenols	10-21	tumor necrosis factor	Homo sapiens	96-105
27595387-1	2016	Recently, increasing attention has been paid to the marine algae as a natural source of novel angiotensin-I converting enzyme (ACE) inhibitors, such as the phlorotannins that are the predominant polyphenols in brown algae.	Polyphenols	195-206	angiotensin I converting enzyme	Homo sapiens	127-130
29450132-0	2016	Green tea polyphenols affect invasiveness of human gastric MKN-28 cells by inhibition of LPS or TNF-alpha induced Matrix Metalloproteinase-9/2.	Polyphenols	10-21	matrix metallopeptidase 9	Homo sapiens	114-142
29450132-10	2016	In conclusion, our results demonstrated that green tea polyphenol extract reduces the invasiveness of gastric MKN-28 cancer cells through the reduction of TNF-alpha or LPS induced MMP-9/2 up-regulation.	Polyphenols	55-65	tumor necrosis factor	Homo sapiens	155-164
29450132-10	2016	In conclusion, our results demonstrated that green tea polyphenol extract reduces the invasiveness of gastric MKN-28 cancer cells through the reduction of TNF-alpha or LPS induced MMP-9/2 up-regulation.	Polyphenols	55-65	matrix metallopeptidase 9	Homo sapiens	180-185
27453478-0	2016	Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing.	Polyphenols	28-39	mechanistic target of rapamycin kinase	Homo sapiens	10-14
27716626-4	2016	In numerous studies, polyphenols, including quercetin, demonstrated their ability to suppress TNFalpha secretion and protect from the onset of chronic inflammatory disorders.	Polyphenols	21-32	tumor necrosis factor	Homo sapiens	94-102
27716626-6	2016	Slpi is known to suppress LPS mediated NFkappaB activation, thus, it was hypothesized that its expression could be the key step for polyphenol induced inflammatory suppression.	Polyphenols	132-142	secretory leukocyte peptidase inhibitor	Homo sapiens	0-4
27453478-3	2016	Herein, we will discuss the mechanisms by which polyphenols can delay the molecular pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways.	Polyphenols	48-59	mechanistic target of rapamycin kinase	Homo sapiens	159-163
27453478-4	2016	We will also discuss the implications of polyphenols in targeting mTOR and its related pathways on health life span extension and longevity..	Polyphenols	41-52	mechanistic target of rapamycin kinase	Homo sapiens	66-70
27338284-0	2016	Inhibition of green tea polyphenol EGCG((-)-epigallocatechin-3-gallate) on the proliferation of gastric cancer cells by suppressing canonical wnt/beta-catenin signalling pathway.	Polyphenols	24-34	catenin beta 1	Homo sapiens	146-158
29634116-2	2016	The protective effects of polyphenol-rich extract from berries of A. melanocarpa against changes in biological properties of fibrinogen were studied.	Polyphenols	26-36	fibrinogen beta chain	Homo sapiens	125-135
29634116-8	2016	The experiments also indicate that polyphenol-rich extract from black chokeberries (at final concentrations of 2.5-10 pM/mL) reduced the toxic action of Hey and HTL on the adhesive properties of fibrinogen.	Polyphenols	35-45	fibrinogen beta chain	Homo sapiens	195-205
27882175-0	2016	Tea polyphenols protect against ischemia/reperfusion-induced liver injury in mice through anti-oxidative and anti-apoptotic properties.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
27882175-1	2016	Tea polyphenols (TPs), which are derived from tea extracts, are a class of chemicals containing polyphenol hydroxyls that have been observed to have strong anti-oxidative properties.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
27882175-1	2016	Tea polyphenols (TPs), which are derived from tea extracts, are a class of chemicals containing polyphenol hydroxyls that have been observed to have strong anti-oxidative properties.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	46-49
27792767-3	2016	The aim of this study was to evaluate the association between the intake of polyphenols and hypertension in a general population of Sao Paulo.	Polyphenols	76-87	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	132-135
27550943-0	2016	A Novel Polyphenol Conjugate Sensitizes Cisplatin-Resistant Head and Neck Cancer Cells to Cisplatin via Nrf2 Inhibition.	Polyphenols	8-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
27843913-3	2016	The tyrosinase enzyme is highly active in melanoma cells and metabolizes polyphenolic compounds; tyrosinase expression thus makes feasible a target for polyphenol-based therapies.	Polyphenols	73-83	tyrosinase	Homo sapiens	4-14
27843913-3	2016	The tyrosinase enzyme is highly active in melanoma cells and metabolizes polyphenolic compounds; tyrosinase expression thus makes feasible a target for polyphenol-based therapies.	Polyphenols	73-83	tyrosinase	Homo sapiens	97-107
27740603-0	2016	Relationship between the Ingestion of a Polyphenol-Rich Drink, Hepcidin Hormone, and Long-Term Training.	Polyphenols	40-50	hepcidin antimicrobial peptide	Homo sapiens	63-71
27694956-0	2016	Prediction and evaluation of the lipase inhibitory activities of tea polyphenols with 3D-QSAR models.	Polyphenols	69-80	lipase G, endothelial type	Rattus norvegicus	33-39
27417135-2	2016	Herein, we investigated the effects of a potential Nrf2 modulator, salvianolic acid A (SAA), which is a natural polyphenol, on diabetes-associated macrovascular and renal injuries in streptozotocin-induced diabetic mice.	Polyphenols	112-122	serum amyloid A cluster	Mus musculus	87-90
27417135-8	2016	These findings suggested that polyphenol Nrf2 modulators, especially combined with drugs activating AMP-activated protein kinase, including hypoglycemic drugs, are worthy of further investigation to combat diabetic complications.	Polyphenols	30-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
26926494-0	2016	Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy.	Polyphenols	29-40	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
26926494-5	2016	Many studies suggest that dozens of natural compounds, including polyphenols, can supress oxidative stress and inflammation through targeting Nrf2 and consequently activating the antioxidant response element-related cytoprotective genes.	Polyphenols	65-76	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
26926494-7	2016	In the present article, we will focus on the role of Nrf2 in diabetic retinopathy and the ability of polyphenols to target Nrf2 as a therapeutic strategy.	Polyphenols	101-112	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
26452735-4	2016	HPLC analysis showed that polyphenols were able to permeate from the water extracts of studied plants into the undifferentiated myoblasts as well as myocytes undergoing differentiation, increasing the concentration of reduced glutathione and upregulating glutathione reductase and peroxidase activity.	Polyphenols	26-37	glutathione reductase	Mus musculus	255-276
27132823-0	2016	Interactions between polyphenols in thinned young apples and porcine pancreatic alpha-amylase: Inhibition, detailed kinetics and fluorescence quenching.	Polyphenols	21-32	probable alpha-amylase 2	Malus domestica	80-93
27132823-6	2016	Thus, combining detailed kinetics and fluorescence quenching studies can be applied to characterise the interactions between polyphenols in young apples and alpha-amylase.	Polyphenols	125-136	probable alpha-amylase 2	Malus domestica	157-170
27669317-2	2016	Previous studies have shown that polyphenols from dark-colored fruits can reduce stress-mediated signaling in BV-2 mouse microglial cells, leading to decreases in nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression.	Polyphenols	33-44	nitric oxide synthase 2, inducible	Mus musculus	196-227
27692159-4	2016	Previous evidence from animal and human studies found that tea polyphenols can reduce serum leptin levels in vivo and inhibit the expression of leptin in adipose tissue.	Polyphenols	63-74	leptin	Homo sapiens	92-98
27692159-4	2016	Previous evidence from animal and human studies found that tea polyphenols can reduce serum leptin levels in vivo and inhibit the expression of leptin in adipose tissue.	Polyphenols	63-74	leptin	Homo sapiens	144-150
27692159-5	2016	This article focus on whether tea polyphenols could delay the onset of puberty by reducing leptin levels.	Polyphenols	34-45	leptin	Homo sapiens	91-97
27865352-10	2016	These results suggest that plum polyphenols may exhibit a chemopreventive potential against colon carcinogenesis by impacting the AKT/mTOR pathway and miR-143.	Polyphenols	32-43	mechanistic target of rapamycin kinase	Homo sapiens	134-138
27865352-10	2016	These results suggest that plum polyphenols may exhibit a chemopreventive potential against colon carcinogenesis by impacting the AKT/mTOR pathway and miR-143.	Polyphenols	32-43	microRNA 143	Rattus norvegicus	151-158
27190251-10	2016	LY294002 (10 micromol/L), a phosphatidyl-inositol 3 kinase inhibitor (PI3K), reversed the effects of grape powder extracted polyphenols on cellular lipid content and glucose uptake.	Polyphenols	124-135	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	28-68
27560195-7	2016	The polyphenol intervention significantly reduced the levels of VEGF, ROS, IL-8 and ICAM-1, with a more pronounced effect in TNF-alpha-activated endothelial cells.	Polyphenols	4-14	vascular endothelial growth factor A	Homo sapiens	64-68
27560195-7	2016	The polyphenol intervention significantly reduced the levels of VEGF, ROS, IL-8 and ICAM-1, with a more pronounced effect in TNF-alpha-activated endothelial cells.	Polyphenols	4-14	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
27560195-7	2016	The polyphenol intervention significantly reduced the levels of VEGF, ROS, IL-8 and ICAM-1, with a more pronounced effect in TNF-alpha-activated endothelial cells.	Polyphenols	4-14	intercellular adhesion molecule 1	Homo sapiens	84-90
27560195-7	2016	The polyphenol intervention significantly reduced the levels of VEGF, ROS, IL-8 and ICAM-1, with a more pronounced effect in TNF-alpha-activated endothelial cells.	Polyphenols	4-14	tumor necrosis factor	Homo sapiens	125-134
27669317-2	2016	Previous studies have shown that polyphenols from dark-colored fruits can reduce stress-mediated signaling in BV-2 mouse microglial cells, leading to decreases in nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression.	Polyphenols	33-44	nitric oxide synthase 2, inducible	Mus musculus	229-233
27610044-15	2016	Polyphenols prevented the stimulation of Akt phosphorylation, and in some cases also ERK phosphorylation.	Polyphenols	0-11	AKT serine/threonine kinase 1	Homo sapiens	41-44
27339657-0	2016	Botanical Polyphenols Mitigate Microglial Activation and Microglia-Induced Neurotoxicity: Role of Cytosolic Phospholipase A2.	Polyphenols	10-21	phospholipase A2 group IVA	Homo sapiens	98-124
27567859-0	2016	The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.	Polyphenols	4-14	poly (ADP-ribose) polymerase family, member 1	Mus musculus	49-54
27567859-0	2016	The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.	Polyphenols	4-14	sirtuin 1	Mus musculus	55-60
26443197-0	2016	Glycation of human serum albumin alters its binding efficacy towards the dietary polyphenols: a comparative approach.	Polyphenols	81-92	albumin	Homo sapiens	19-32
27376855-0	2016	Species difference in reactivity to lignin-like enzymatically polymerized polyphenols on interferon-gamma synthesis and involvement of interleukin-2 production in mice.	Polyphenols	74-85	interferon gamma	Mus musculus	89-105
27376855-6	2016	To clarify these different points in soluble factors, multiplex cytokine profiling analysis was carried out and we identified interleukin (IL)-2 as a key molecule for IFN-gamma induction by polymerized polyphenols.	Polyphenols	202-213	interleukin 2	Mus musculus	126-144
27376855-6	2016	To clarify these different points in soluble factors, multiplex cytokine profiling analysis was carried out and we identified interleukin (IL)-2 as a key molecule for IFN-gamma induction by polymerized polyphenols.	Polyphenols	202-213	interferon gamma	Mus musculus	167-176
27520400-2	2016	The polyphenol resveratrol is considered to exert many beneficial actions, such as antioxidant, anti-inflammatory, insulin-sensitizer and anticancer effects.	Polyphenols	4-14	insulin	Homo sapiens	115-122
27632920-1	2016	In the present study, we hypothesized that defatted safflower seed which is known to be rich in polyphenols might influence adipogenesis and obesity-related disorders, and therefore the anti-adipogenic and hypolipidemic effects of ethanol extract from defatted safflower (Cathamus tinctorius L.) seeds (CSE) were investigated both in cultured 3T3-L1 preadipocytes and in C57BL/6J ob/ob mice fed a high-fat diet.	Polyphenols	96-107	cystathionase (cystathionine gamma-lyase)	Mus musculus	303-306
27320865-3	2016	The current study aimed to investigate the potential efficacy of agrimol B, a polyphenol derived from Agrimonia pilosa Ledeb., on mediating SIRT1 activity and fat metabolism.	Polyphenols	78-88	sirtuin 1	Homo sapiens	140-145
27589705-0	2016	Red Grape Skin Polyphenols Blunt Matrix Metalloproteinase-2 and -9 Activity and Expression in Cell Models of Vascular Inflammation: Protective Role in Degenerative and Inflammatory Diseases.	Polyphenols	15-26	matrix metallopeptidase 2	Homo sapiens	33-66
29441847-3	2016	Resveratrol (RSV), a polyphenol from the skins of grapes and red wine, is an activator of SIRT3.	Polyphenols	21-31	sirtuin 3	Mus musculus	90-95
27083387-6	2016	Hence, in this review, the pivotal role of TNF in NSAID enteropathy has been summarized and plant-derived polyphenols have been suggested as useful alternative anti-TNF agents because of their ability to suppress TNF activated inflammatory pathways both in vitro and in vivo.	Polyphenols	106-117	tumor necrosis factor	Homo sapiens	165-168
27083387-6	2016	Hence, in this review, the pivotal role of TNF in NSAID enteropathy has been summarized and plant-derived polyphenols have been suggested as useful alternative anti-TNF agents because of their ability to suppress TNF activated inflammatory pathways both in vitro and in vivo.	Polyphenols	106-117	tumor necrosis factor	Homo sapiens	165-168
27311853-2	2016	In this study, we discovered the inhibitory activity of the polyphenol compound (1) in DSS induced colitis in mice by targeting NFkappaB/IL-6/STAT3 pathway.	Polyphenols	60-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-136
27159149-2	2016	Some nutraceuticals, such as flavonoids and natural polyphenols, have recently been investigated as modulators of the self-assembly process of TTR, but they generally suffer from limited bioavailability.	Polyphenols	52-63	transthyretin	Homo sapiens	143-146
27311853-2	2016	In this study, we discovered the inhibitory activity of the polyphenol compound (1) in DSS induced colitis in mice by targeting NFkappaB/IL-6/STAT3 pathway.	Polyphenols	60-70	interleukin 6	Mus musculus	137-141
27311853-2	2016	In this study, we discovered the inhibitory activity of the polyphenol compound (1) in DSS induced colitis in mice by targeting NFkappaB/IL-6/STAT3 pathway.	Polyphenols	60-70	signal transducer and activator of transcription 3	Mus musculus	142-147
27311853-7	2016	Moreover, this polyphenol suppressed p-STAT3 production as well as its downstream proteins response for apoptosis, such as Bcl-2 and Bax.	Polyphenols	15-25	signal transducer and activator of transcription 3	Mus musculus	39-44
27311853-7	2016	Moreover, this polyphenol suppressed p-STAT3 production as well as its downstream proteins response for apoptosis, such as Bcl-2 and Bax.	Polyphenols	15-25	B cell leukemia/lymphoma 2	Mus musculus	123-128
27311853-7	2016	Moreover, this polyphenol suppressed p-STAT3 production as well as its downstream proteins response for apoptosis, such as Bcl-2 and Bax.	Polyphenols	15-25	BCL2-associated X protein	Mus musculus	133-136
26441376-2	2016	The infusion contains polyphenols that have been proposed to induce antioxidant response element (ARE) response via nuclear factor E2-related factor 2 (NRF2).	Polyphenols	22-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	152-156
27389300-0	2016	Fabrication of BSA-Green Tea Polyphenols-Chitosan Nanoparticles and Their Role in Radioprotection: A Molecular and Biochemical Approach.	Polyphenols	29-40	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	25-28
27389300-2	2016	Tea polyphenols (TPs) have been shown to reduce radiation-induced damage in multiple studies, but their pharmacological application is still limited due to poor bioavailability.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
27278405-8	2016	Consistent with this, the polyphenol components of the PFRF inhibited alpha-amylase (green tea, strawberry, blackberry and blackcurrant) and alpha-glucosidase (green tea) activities in vitro.	Polyphenols	26-36	sucrase-isomaltase	Homo sapiens	141-158
27722032-9	2016	Treatment with fisetin (0.5 mM), a polyphenol compound with PARP1 inhibitory property, for 24 h also suppressed the expression of DUX4 (44.8 fold, p&lt;0.01) and ZSCAN4 (2.2 fold, p&lt;0.05) in the FSHD myoblasts.	Polyphenols	35-45	poly(ADP-ribose) polymerase 1	Homo sapiens	60-65
27722032-9	2016	Treatment with fisetin (0.5 mM), a polyphenol compound with PARP1 inhibitory property, for 24 h also suppressed the expression of DUX4 (44.8 fold, p&lt;0.01) and ZSCAN4 (2.2 fold, p&lt;0.05) in the FSHD myoblasts.	Polyphenols	35-45	Double homeobox protein 10	Homo sapiens	130-134
27722032-9	2016	Treatment with fisetin (0.5 mM), a polyphenol compound with PARP1 inhibitory property, for 24 h also suppressed the expression of DUX4 (44.8 fold, p&lt;0.01) and ZSCAN4 (2.2 fold, p&lt;0.05) in the FSHD myoblasts.	Polyphenols	35-45	zinc finger and SCAN domain containing 4	Homo sapiens	162-168
27356022-3	2016	SULT1A1, a major phase II metabolism SULT isoform, is found at a high concentration in liver and has recently been show to harbor two allosteric binding sites, each of which binds a separate and complex class of compounds: the catechins (naturally occurring polyphenols) and nonsteroidal anti-inflammatory drugs.	Polyphenols	258-269	sulfotransferase family 1A member 1	Homo sapiens	0-7
27383500-0	2016	Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer"s disease in vitro.	Polyphenols	44-55	apolipoprotein E	Mus musculus	101-105
27306892-2	2016	Certain plant polyphenols inhibit TLR-mediated signaling pathways.	Polyphenols	14-25	toll like receptor 2	Homo sapiens	34-37
27130653-0	2016	Interaction of KRAS G-quadruplex with natural polyphenols: A spectroscopic analysis with molecular modeling.	Polyphenols	46-57	KRAS proto-oncogene, GTPase	Homo sapiens	15-19
26538333-0	2016	Extractable and non-extractable polyphenols from blueberries modulate LPS-induced expression of iNOS and COX-2 in RAW264.7 macrophages via the NF-kappaB signalling pathway.	Polyphenols	32-43	nitric oxide synthase 2	Homo sapiens	96-100
26538333-0	2016	Extractable and non-extractable polyphenols from blueberries modulate LPS-induced expression of iNOS and COX-2 in RAW264.7 macrophages via the NF-kappaB signalling pathway.	Polyphenols	32-43	prostaglandin-endoperoxide synthase 2	Mus musculus	105-110
26538333-0	2016	Extractable and non-extractable polyphenols from blueberries modulate LPS-induced expression of iNOS and COX-2 in RAW264.7 macrophages via the NF-kappaB signalling pathway.	Polyphenols	32-43	nuclear factor kappa B subunit 1	Homo sapiens	143-152
26463658-5	2016	Induction of cell death mechanisms, production of reactive oxygen species, and drug resistance mechanisms, including p-glycoprotein efflux, are among the best-described effects triggered by the flavonoid polyphenol family.	Polyphenols	204-214	ATP binding cassette subfamily B member 1	Homo sapiens	117-131
27270317-2	2016	Our previous study revealed that the green tea polyphenol, EGCG, induced cisplatin transporter CTR1 (copper transporter 1) and enhanced cisplatin sensitivity in ovarian cancer.	Polyphenols	47-57	solute carrier family 31 member 1	Homo sapiens	95-99
27270317-2	2016	Our previous study revealed that the green tea polyphenol, EGCG, induced cisplatin transporter CTR1 (copper transporter 1) and enhanced cisplatin sensitivity in ovarian cancer.	Polyphenols	47-57	solute carrier family 31 member 1	Homo sapiens	101-121
27239812-14	2016	Polyphenols scavenged Pb induced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway.	Polyphenols	0-11	mitogen activated protein kinase 3	Rattus norvegicus	76-79
27166148-2	2016	Our recent studies with immortalized murine microglial cells (BV-2) demonstrated effects of botanical polyphenols to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) and enhance Nrf2-mediated antioxidant responses (Sun et al., 2015).	Polyphenols	102-113	nuclear factor, erythroid derived 2, like 2	Mus musculus	188-192
27166148-10	2016	In summary, this study demonstrated NF-kB and Nrf2/ARE promoter activities in DI TNC1 astrocytes, and further showed differences in ability for specific botanical polyphenols and extracts to down-regulate LPS-induced NF-kB and up-regulate the NRF2/ARE activities in these cells.	Polyphenols	163-174	NFE2 like bZIP transcription factor 2	Rattus norvegicus	243-247
27122127-0	2016	Polyphenols from Korean prostrate spurge Euphorbia supina induce apoptosis through the Fas-associated extrinsic pathway and activation of ERK in human leukemic U937 cells.	Polyphenols	0-11	mitogen-activated protein kinase 1	Homo sapiens	138-141
28955914-3	2016	This study demonstrates that the non-toxic, naturally-occurring polyphenol resveratrol (RES) induces increases in [Ca2+] i via PMCA inhibition in primary dermal fibroblasts and MDA-MB-231 breast cancer cells.	Polyphenols	64-74	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	127-131
27093251-0	2016	A Polyphenol-Enriched Fraction of Rose Oil Distillation Wastewater Inhibits Cell Proliferation, Migration and TNF-alpha-Induced VEGF Secretion in Human Immortalized Keratinocytes.	Polyphenols	2-12	tumor necrosis factor	Homo sapiens	110-119
27093251-0	2016	A Polyphenol-Enriched Fraction of Rose Oil Distillation Wastewater Inhibits Cell Proliferation, Migration and TNF-alpha-Induced VEGF Secretion in Human Immortalized Keratinocytes.	Polyphenols	2-12	vascular endothelial growth factor A	Homo sapiens	128-132
27239812-14	2016	Polyphenols scavenged Pb induced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway.	Polyphenols	0-11	mitogen activated protein kinase 14	Rattus norvegicus	84-87
27338244-10	2016	CONCLUSIONS: We highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption.	Polyphenols	113-124	paraoxonase 1	Homo sapiens	69-73
27285995-4	2016	The objective of the present study was to determine the contribution of individual polyphenols to the effect of combined RQC on mTOR signaling.	Polyphenols	83-94	mechanistic target of rapamycin kinase	Homo sapiens	128-132
27130545-0	2016	High-dose green tea polyphenol intake decreases CYP3A expression in a liver-specific manner with increases in blood substrate drug concentrations.	Polyphenols	20-30	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	48-53
27257341-4	2016	Of the four polyphenols tested, CAPE significantly suppressed the 12-O-tetradecanoylphorbol 13-acetate (TPA)-elicited expression of cluster for differentiation (CD) 11b, 14, and 36, and this was accompanied by the inhibition of THP-1 cell adhesion to HUVEC.	Polyphenols	12-23	integrin subunit alpha M	Homo sapiens	132-168
27285995-3	2016	We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells.	Polyphenols	51-62	thymoma viral proto-oncogene 1	Mus musculus	212-215
27285995-3	2016	We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells.	Polyphenols	51-62	mechanistic target of rapamycin kinase	Mus musculus	220-224
27285995-3	2016	We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells.	Polyphenols	51-62	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	250-254
27285995-3	2016	We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells.	Polyphenols	51-62	mechanistic target of rapamycin kinase	Mus musculus	283-287
26964795-7	2016	These effects were associated with the activation of PGC-1alpha/Sirt1/AMPK axis by both polyphenols.	Polyphenols	88-99	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	53-63
26964795-7	2016	These effects were associated with the activation of PGC-1alpha/Sirt1/AMPK axis by both polyphenols.	Polyphenols	88-99	sirtuin 1	Mus musculus	64-69
27043127-4	2016	Anthocyanin, a subclass of the polyphenol family flavonoids has been shown to exhibit anti-dyslipidemic and anti-thrombotic properties by virtue of its antioxidant activity.	Polyphenols	31-41	DDB1 and CUL4 associated factor 7	Homo sapiens	0-11
27168833-0	2016	Preventive activity of banana peel polyphenols on CCl4-induced experimental hepatic injury in Kunming mice.	Polyphenols	35-46	chemokine (C-C motif) ligand 4	Mus musculus	50-54
26081647-12	2016	CONCLUSION: This study describes the large number of dietary individual polyphenols consumed and the high variability of their intakes between European populations, particularly between MED and non-MED countries.	Polyphenols	72-83	collagen type IX alpha 3 chain	Homo sapiens	186-189
26081647-12	2016	CONCLUSION: This study describes the large number of dietary individual polyphenols consumed and the high variability of their intakes between European populations, particularly between MED and non-MED countries.	Polyphenols	72-83	collagen type IX alpha 3 chain	Homo sapiens	198-201
27058323-0	2016	Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
27109860-1	2016	Coffee is a rich source of polyphenols, primarily chlorogenic acids (CGA).	Polyphenols	27-38	chromogranin A	Homo sapiens	69-72
27164138-0	2016	Polyphenol-Rich Propolis Extracts Strengthen Intestinal Barrier Function by Activating AMPK and ERK Signaling.	Polyphenols	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	87-91
27164138-0	2016	Polyphenol-Rich Propolis Extracts Strengthen Intestinal Barrier Function by Activating AMPK and ERK Signaling.	Polyphenols	0-10	mitogen-activated protein kinase 1	Homo sapiens	96-99
27025786-2	2016	Curcumin, a bioactive polyphenol from turmeric, has been shown in several preclinical studies to block TNF-alpha effectively.	Polyphenols	22-32	tumor necrosis factor	Homo sapiens	103-112
26895335-12	2016	Decreased activity of dihydroflavonol 4-reductase and chalcone synthase/chalcone isomerase could partially explain the lower polyphenol concentrations.	Polyphenols	125-135	bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase	Malus domestica	22-49
29235333-10	2016	The polyphenol also potentiated replenishing of intracellular IL-6 and IL-10 concentrations and their secretion into incubation medium.	Polyphenols	4-14	interleukin 6	Homo sapiens	62-66
27090627-15	2016	All five polyphenols and flunixin meglumine significantly decreased lymphocyte production of IFN-gamma, while only hydroxypterostilbene, pterostilbene, quercetin, and resveratrol significantly reduced lymphocyte production of TNF-alpha compared to the positive control (p &lt; 0.05).	Polyphenols	9-20	interferon gamma	Equus caballus	93-102
27279695-4	2016	MATERIALS AND METHODS: The in vitro effects of these selected polyphenols on MAO activities in mitochondria isolated from rat brains were examined.	Polyphenols	62-73	monoamine oxidase A	Rattus norvegicus	77-80
29235333-10	2016	The polyphenol also potentiated replenishing of intracellular IL-6 and IL-10 concentrations and their secretion into incubation medium.	Polyphenols	4-14	interleukin 10	Homo sapiens	71-76
27050780-3	2016	As a proof of concept, we synthesized polyphenol-coated mesoporous silica nanoparticles, termed MSN@polyphenol.	Polyphenols	38-48	moesin	Homo sapiens	96-99
27110686-2	2016	Recent work by our group and others has shown that the natural polyphenol curcumin attenuates the development of insulin resistance and hyperglycemia in mouse models of hyperinsulinemic or compensated type 2 diabetes.	Polyphenols	63-73	insulin	Homo sapiens	113-120
27050780-3	2016	As a proof of concept, we synthesized polyphenol-coated mesoporous silica nanoparticles, termed MSN@polyphenol.	Polyphenols	100-110	moesin	Homo sapiens	96-99
26879600-5	2016	Several studies, mostly based on in vitro and animal models, indicate that dietary polyphenols, mainly flavonoids, positively modulate the insulin signalling pathway by attenuating hyperglycaemia and insulin resistance, reducing inflammatory adipokines, and modifying microRNA (miRNA) profiles.	Polyphenols	83-94	insulin	Homo sapiens	139-146
26879600-5	2016	Several studies, mostly based on in vitro and animal models, indicate that dietary polyphenols, mainly flavonoids, positively modulate the insulin signalling pathway by attenuating hyperglycaemia and insulin resistance, reducing inflammatory adipokines, and modifying microRNA (miRNA) profiles.	Polyphenols	83-94	insulin	Homo sapiens	200-207
27041235-0	2016	A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.	Polyphenols	10-20	sirtuin 1	Homo sapiens	115-120
33465868-9	2016	The mucoadhesion originated from intermolecular interaction between the polyphenols of TA and mucin, exhibiting pH dependency.	Polyphenols	72-83	LOC100508689	Homo sapiens	94-99
27041235-6	2016	(2013) A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.	Polyphenols	17-27	sirtuin 1	Homo sapiens	122-127
26960417-0	2016	Low-molecular-weight polyphenols protect kidney damage through suppressing NF-kappaB and modulating mitochondrial biogenesis in diabetic db/db mice.	Polyphenols	21-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
26499783-0	2016	Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1.	Polyphenols	10-20	fibronectin type III and SPRY domain containing 1 like	Homo sapiens	83-88
26179241-3	2016	The cranberry contains anti-inflammatory polyphenols, which inhibit proinflammatory activities of lipopolysaccharide (LPS)- and IL-1beta-stimulated human cells.	Polyphenols	41-52	interleukin 1 beta	Homo sapiens	128-136
27212904-0	2016	Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products.	Polyphenols	66-77	reticulon 4	Homo sapiens	17-23
26814424-11	2016	Thirty four polyphenols could be detected and successfully estimated and showed large interindividual variations of concentrations (2-3 orders of magnitude depending on the compound), with median concentrations spanning from 0.01 to over 1000 muM for all 34 compounds.	Polyphenols	12-23	latexin	Homo sapiens	243-246
26810764-0	2016	Dietary intake and food contributors of polyphenols in adults and elderly adults of Sao Paulo: a population-based study.	Polyphenols	40-51	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	84-87
26810764-2	2016	The aim of this study was to estimate the intake of polyphenols and the major dietary contributors in the population of Sao Paulo.	Polyphenols	52-63	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	120-123
26836197-9	2016	These findings justified the concept that polyphenol-mediated modulation of LDLR expression might serve as a safe and efficient disease-modifying therapy for AD by accelerating Abeta clearance.	Polyphenols	42-52	low density lipoprotein receptor	Mus musculus	76-80
26836197-9	2016	These findings justified the concept that polyphenol-mediated modulation of LDLR expression might serve as a safe and efficient disease-modifying therapy for AD by accelerating Abeta clearance.	Polyphenols	42-52	amyloid beta (A4) precursor protein	Mus musculus	177-182
27023113-11	2016	It can be speculated that this MPO activity-promoting effect of EGCG may contribute to the pharmacological mode of action of this polyphenol.	Polyphenols	130-140	myeloperoxidase	Rattus norvegicus	31-34
26903826-7	2016	These behavioral results were associated with neurobiological changes: while the expression of hippocampal calmodulin kinase II (CaMKII) mRNA levels was reduced in middle-aged animals, the polyphenol-enriched diet could rescue them.	Polyphenols	189-199	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	107-127
26807478-0	2016	Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenol.	Polyphenols	154-164	cAMP responsive element binding protein 1	Homo sapiens	101-105
26807478-0	2016	Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenol.	Polyphenols	154-164	H3 histone pseudogene 16	Homo sapiens	115-118
26807478-2	2016	Salvianolic acid A (SAA) is one of the most abundant polyphenols extracted from salvia.	Polyphenols	53-64	serum amyloid A1 cluster	Homo sapiens	20-23
26876758-2	2016	In studies of both humans and rodents, resveratrol, a natural polyphenol, has been reported to provide protection from cerebral ischemic injury by regulating expression of silent mating type information regulation 2 homolog 1 (SIRT1).	Polyphenols	62-72	sirtuin 1	Homo sapiens	227-232
27047322-0	2016	Plant polyphenols can protect VEGF-induced vascular leakage?	Polyphenols	6-17	vascular endothelial growth factor A	Homo sapiens	30-34
26926184-7	2016	Importantly, some polyphenols also inhibit the activity of matrix metalloproteinases, inhibit angiotensin converting enzyme activity and thereby improving SBP and DSB.	Polyphenols	18-29	selenium binding protein 1	Homo sapiens	155-158
26926184-9	2016	CONCLUSION: The antihypertensive phytotherapy of polyphenol-rich foods for protection and improving endothelial function with vascular relaxation occurs via the NO-cGMP pathway and ACE inhibition.	Polyphenols	49-59	angiotensin I converting enzyme	Homo sapiens	181-184
26863418-0	2016	Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations.	Polyphenols	57-68	MDM2 proto-oncogene	Homo sapiens	38-42
26863418-3	2016	In the present study, we elucidated the MDM2 inhibition potential of polyphenols (Apigenin, Fisetin, Galangin and Luteolin) by MD simulation and MM/PBSA free energy calculations.	Polyphenols	69-80	MDM2 proto-oncogene	Homo sapiens	40-44
26863418-4	2016	All polyphenols bind to hydrophobic groove of MDM2 and the binding was found to be stable throughout MD simulation.	Polyphenols	4-15	MDM2 proto-oncogene	Homo sapiens	46-50
26582073-0	2016	Stachyose increases absorption and hepatoprotective effect of tea polyphenols in high fructose-fed mice.	Polyphenols	66-77	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	62-65
26582073-1	2016	SCOPE: The consumption of tea polyphenols (TP) and stachyose contributes to preventive effects on hepatic injury.	Polyphenols	30-41	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	26-29
26626705-0	2016	Dietary polyphenol morin rescues endothelial dysfunction in a diabetic mouse model by activating the Akt/eNOS pathway.	Polyphenols	8-18	thymoma viral proto-oncogene 1	Mus musculus	101-104
26903826-7	2016	These behavioral results were associated with neurobiological changes: while the expression of hippocampal calmodulin kinase II (CaMKII) mRNA levels was reduced in middle-aged animals, the polyphenol-enriched diet could rescue them.	Polyphenols	189-199	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	129-135
26612114-0	2016	White bread enriched with polyphenol extracts shows no effect on glycemic response or satiety, yet may increase postprandial insulin economy in healthy participants.	Polyphenols	26-36	insulin	Homo sapiens	125-132
26851025-8	2016	RESULTS: Both polyphenols inhibited proliferation, induced apoptotic cell death and blocked IL2 synthesis in Jurkat T-cells.	Polyphenols	14-25	interleukin 2	Homo sapiens	92-95
26878794-2	2016	It is well known that bioactive food compounds such as polyphenols may exert their protection by modulating inflammatory pathways regulated through nuclear factor-kappa B (NF-kappaB) signaling.	Polyphenols	55-66	nuclear factor kappa B subunit 1	Homo sapiens	148-170
26878794-2	2016	It is well known that bioactive food compounds such as polyphenols may exert their protection by modulating inflammatory pathways regulated through nuclear factor-kappa B (NF-kappaB) signaling.	Polyphenols	55-66	nuclear factor kappa B subunit 1	Homo sapiens	172-181
26443543-3	2016	Although polyphenols can induce the expression of MnSOD, their corresponding mechanisms remains unclear.	Polyphenols	9-20	superoxide dismutase 2	Homo sapiens	50-55
26612114-2	2016	It was hypothesized that extracts rich in polyphenols, added to white bread, would improve the glycemic response and insulin response and increase satiety in healthy participants.	Polyphenols	42-53	insulin	Homo sapiens	117-124
26821011-1	2016	Dihydroflavanol 4-reductase (DFR) is a key later enzyme involved in two polyphenols" (anthocyanins and proanthocyanidins (PAs)) biosynthesis, however it is not characterized in cotton yet.	Polyphenols	72-83	dihydroflavonol-4-reductase-like	Gossypium hirsutum	0-27
27069731-2	2016	Polyphenols have variable potencies to interact, and hence alter the activities of various transporter proteins, many of them classified as anion transporting polypeptide-binding cassette transporters like multidrug resistance protein and p-glycoprotein.	Polyphenols	0-11	ATP binding cassette subfamily B member 1	Homo sapiens	239-253
26821011-1	2016	Dihydroflavanol 4-reductase (DFR) is a key later enzyme involved in two polyphenols" (anthocyanins and proanthocyanidins (PAs)) biosynthesis, however it is not characterized in cotton yet.	Polyphenols	72-83	dihydroflavonol-4-reductase-like	Gossypium hirsutum	29-32
26755859-3	2016	Antioxidant phytochemicals, such as polyphenols, regulate the expression of ALD-associated proteins and peptides, namely, catalase, superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase.	Polyphenols	36-47	catalase	Homo sapiens	122-130
26800359-18	2016	Various vegetable polyphenols (luteolin, quercetin, apigenin) inhibited the hyperosmotic expression of bFGF, HB-EGF, and NFAT5 genes.	Polyphenols	18-29	fibroblast growth factor 2	Homo sapiens	103-107
26800359-18	2016	Various vegetable polyphenols (luteolin, quercetin, apigenin) inhibited the hyperosmotic expression of bFGF, HB-EGF, and NFAT5 genes.	Polyphenols	18-29	heparin binding EGF like growth factor	Homo sapiens	109-115
26800359-18	2016	Various vegetable polyphenols (luteolin, quercetin, apigenin) inhibited the hyperosmotic expression of bFGF, HB-EGF, and NFAT5 genes.	Polyphenols	18-29	nuclear factor of activated T cells 5	Homo sapiens	121-126
26655811-0	2016	Nrf2 transcriptional derepression from Keap1 by dietary polyphenols.	Polyphenols	56-67	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
26655811-0	2016	Nrf2 transcriptional derepression from Keap1 by dietary polyphenols.	Polyphenols	56-67	kelch like ECH associated protein 1	Homo sapiens	39-44
26655811-5	2016	Nrf2 inhibition by RNA interference reduced polyphenol effects on its target gene expression.	Polyphenols	44-54	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
26655811-6	2016	Our data suggest that polyphenols may induce cellular defense genes by derepressing Nrf2 inhibition by Keap1.	Polyphenols	22-33	NFE2 like bZIP transcription factor 2	Homo sapiens	84-88
26655811-6	2016	Our data suggest that polyphenols may induce cellular defense genes by derepressing Nrf2 inhibition by Keap1.	Polyphenols	22-33	kelch like ECH associated protein 1	Homo sapiens	103-108
26655811-7	2016	We posit that this ability to derepress Nrf2 and reactivate its target genes may underlie the protection conferred by polyphenols against oxidative stress-related diseases.	Polyphenols	118-129	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
26754091-2	2016	Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) inhibits melanoma tumor growth by activating 67-kDa laminin receptor (67LR) signaling.	Polyphenols	10-20	ribosomal protein SA	Homo sapiens	106-129
26754091-2	2016	Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) inhibits melanoma tumor growth by activating 67-kDa laminin receptor (67LR) signaling.	Polyphenols	10-20	ribosomal protein SA	Homo sapiens	131-135
26755859-3	2016	Antioxidant phytochemicals, such as polyphenols, regulate the expression of ALD-associated proteins and peptides, namely, catalase, superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase.	Polyphenols	36-47	glutathione-disulfide reductase	Homo sapiens	195-216
26742071-3	2016	Dietary polyphenols may inhibit alpha-amylase and alpha-glucosidase, inhibit glucose absorption in the intestine by sodium-dependent glucose transporter 1 (SGLT1), stimulate insulin secretion and reduce hepatic glucose output.	Polyphenols	8-19	major facilitator superfamily domain containing 4B	Homo sapiens	156-161
26742071-3	2016	Dietary polyphenols may inhibit alpha-amylase and alpha-glucosidase, inhibit glucose absorption in the intestine by sodium-dependent glucose transporter 1 (SGLT1), stimulate insulin secretion and reduce hepatic glucose output.	Polyphenols	8-19	sucrase-isomaltase	Homo sapiens	50-67
26742071-3	2016	Dietary polyphenols may inhibit alpha-amylase and alpha-glucosidase, inhibit glucose absorption in the intestine by sodium-dependent glucose transporter 1 (SGLT1), stimulate insulin secretion and reduce hepatic glucose output.	Polyphenols	8-19	major facilitator superfamily domain containing 4B	Homo sapiens	116-154
26742071-4	2016	Polyphenols may also enhance insulin-dependent glucose uptake, activate 5" adenosine monophosphate-activated protein kinase (AMPK), modify the microbiome and have anti-inflammatory effects.	Polyphenols	0-11	insulin	Homo sapiens	29-36
26701221-0	2016	The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity.	Polyphenols	4-14	apolipoprotein A1	Homo sapiens	55-65
27231728-1	2016	The aim of the study was to investigate the effect of selected polyphenols: gallic acid (GA) and epigallocatechin gallate (EGCG) on matrix metalloproteinase (MMP-2 and MMP-9) activity in multidrug resistant (MDR) human breast adenocarcinoma cells: MCF7/DOX cells and obtained recently in our laboratory MCF7/DOX500 cells by the permanent selection of MCF7/DOX cells with 500 nM doxorubicin (DOX).	Polyphenols	63-74	matrix metallopeptidase 2	Homo sapiens	158-163
27231728-1	2016	The aim of the study was to investigate the effect of selected polyphenols: gallic acid (GA) and epigallocatechin gallate (EGCG) on matrix metalloproteinase (MMP-2 and MMP-9) activity in multidrug resistant (MDR) human breast adenocarcinoma cells: MCF7/DOX cells and obtained recently in our laboratory MCF7/DOX500 cells by the permanent selection of MCF7/DOX cells with 500 nM doxorubicin (DOX).	Polyphenols	63-74	matrix metallopeptidase 9	Homo sapiens	168-173
26900409-10	2016	CONCLUSIONS: The effects of GNPs-Pep-A on ROS reduction and regulation of antioxidant genes confirmed that Vitis vinifera L. polyphenol-coated GNPs synergistically improve the radical scavenging properties and enhanced the apoptosis of cancer cell.	Polyphenols	125-135	carnosine dipeptidase 2	Homo sapiens	33-38
27119082-0	2016	Polyphenols from Chilean Propolis and Pinocembrin Reduce MMP-9 Gene Expression and Activity in Activated Macrophages.	Polyphenols	0-11	matrix metallopeptidase 9	Mus musculus	57-62
26996169-0	2016	In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer"s Disease Treatment.	Polyphenols	32-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
26996169-0	2016	In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer"s Disease Treatment.	Polyphenols	32-43	butyrylcholinesterase	Homo sapiens	70-74
26996169-6	2016	In this study, we selected tea polyphenols of green tea which are reported as AChE and BChE inhibitors used in the treatment of AD.	Polyphenols	31-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82
26996169-6	2016	In this study, we selected tea polyphenols of green tea which are reported as AChE and BChE inhibitors used in the treatment of AD.	Polyphenols	31-42	butyrylcholinesterase	Homo sapiens	87-91
26996169-7	2016	The molecular docking results revealed that polyphenols exhibit interactions and inhibit by binding with AChE and BChE.	Polyphenols	44-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
26996169-7	2016	The molecular docking results revealed that polyphenols exhibit interactions and inhibit by binding with AChE and BChE.	Polyphenols	44-55	butyrylcholinesterase	Homo sapiens	114-118
26996169-10	2016	The present docking study suggests that tea polyphenols inhibit AChE as well as BChE and enhance the cholinergic neurotransmission by prolonging the time.	Polyphenols	44-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
26996169-10	2016	The present docking study suggests that tea polyphenols inhibit AChE as well as BChE and enhance the cholinergic neurotransmission by prolonging the time.	Polyphenols	44-55	butyrylcholinesterase	Homo sapiens	80-84
26268338-5	2016	This structural basis could be useful in predicting GLOI inhibition of other natural polyphenols.	Polyphenols	85-96	glyoxalase I	Homo sapiens	52-56
26517049-6	2016	Small molecules such as polyphenols, peptides as well as large proteins have proven effective at protecting cells against the cytotoxicity of alpha-synuclein.	Polyphenols	24-35	synuclein alpha	Homo sapiens	142-157
27356540-6	2016	RESULTS: Recent findings in animal models and humans show that polyphenols may have a role in regulating neurotrophins levels, in particular nerve growth factor (NGF) and brainderived neurotrophic factor (BDNF), suggesting that polyphenols may also induce their protective effects through the potentiation of neurotrophins action.	Polyphenols	63-74	brain derived neurotrophic factor	Homo sapiens	205-209
27448396-0	2016	Effect of Red Wine Polyphenols on the Expression of Transthyretin in Murine Choroid Plexus.	Polyphenols	19-30	transthyretin	Mus musculus	52-65
27448396-2	2016	The aim of the present experimental work was to evaluate the effect of red wine polyphenols (RWPs) on the expression of transthyretin in murine choroid plexus.	Polyphenols	80-91	transthyretin	Mus musculus	120-133
27448396-3	2016	In contrast to what generally reported in literature for polyphenols, our experimental results indicated a correlation between RWPs assumption and a decrease of transthyretin expression, with a non-dose dependent trend.	Polyphenols	57-68	transthyretin	Mus musculus	161-174
26852865-0	2016	Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance-Associated Protein 2 and Breast Cancer Resistance Protein.	Polyphenols	49-59	ATP binding cassette subfamily C member 2	Homo sapiens	108-149
26514092-2	2016	Hibiscus sabdariffa polyphenols (HPE) inhibited high glucose-induced angiotensin II receptor-1 (AT-1), thus attenuating renal epithelial mesenchymal transition (EMT).	Polyphenols	20-31	angiotensin II receptor, type 1a	Rattus norvegicus	96-100
26421359-12	2016	These data suggest that resveratrol, a natural polyphenol, reduces hippocampal neuronal cell damage following transient global ischemia by reducing MMP-9 activity.	Polyphenols	47-57	matrix metallopeptidase 9	Mus musculus	148-153
26852865-0	2016	Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance-Associated Protein 2 and Breast Cancer Resistance Protein.	Polyphenols	49-59	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	154-186
26881038-5	2016	By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the polyphenol-based dietary supplements that also activate Nrf2.	Polyphenols	129-139	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
26843906-6	2016	On Caco-2 cell model, the polyphenols fractions from chicories have indicated a moderate antioxidant behavior until 17 muM concentration, while 70 muM and 34 muM exert cytotoxic effects for Treviso"s and Castelfranco"s Chicory, respectively, highlighted by TEER decreasing, increased permeability, and alteration of epithelium.	Polyphenols	26-37	latexin	Homo sapiens	119-122
26825069-5	2016	Therefore a series of mixed polyphenol-heterocyclic molecules, were rationally designed by molecular docking as Bax/Bcl-xL inhibitors.	Polyphenols	28-38	BCL2-associated X protein	Mus musculus	112-115
26825069-5	2016	Therefore a series of mixed polyphenol-heterocyclic molecules, were rationally designed by molecular docking as Bax/Bcl-xL inhibitors.	Polyphenols	28-38	BCL2-like 1	Mus musculus	116-122
26304685-9	2016	DISCUSSION: The paradoxical increase in insoluble deposits caused by VMA suggests that these polyphenols divert Abeta aggregation to an alternate, non-toxic form.	Polyphenols	93-104	histocompatibility 2, class II antigen A, beta 1	Mus musculus	112-117
26788243-6	2016	Furthermore, our results demonstrated that green tea polyphenols restored the dysfunction of mitochondrial pro- or antiapoptotic proteins Bax, Bcl-2, and caspase-3 caused by glutamate.	Polyphenols	53-64	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
26788243-6	2016	Furthermore, our results demonstrated that green tea polyphenols restored the dysfunction of mitochondrial pro- or antiapoptotic proteins Bax, Bcl-2, and caspase-3 caused by glutamate.	Polyphenols	53-64	BCL2 apoptosis regulator	Homo sapiens	143-148
26788243-6	2016	Furthermore, our results demonstrated that green tea polyphenols restored the dysfunction of mitochondrial pro- or antiapoptotic proteins Bax, Bcl-2, and caspase-3 caused by glutamate.	Polyphenols	53-64	caspase 3	Homo sapiens	154-163
27538699-5	2016	The aim of the study was to determine the binding sites of both letrozole (LET) and polyphenol product, resveratrol (RES) in tertiary structure of human serum albumin (HSA) based on the fluorescence spectroscopy.	Polyphenols	84-94	albumin	Homo sapiens	153-166
27840668-0	2016	Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation.	Polyphenols	20-31	sirtuin 3	Homo sapiens	78-83
27840668-2	2016	In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria.	Polyphenols	65-76	sirtuin 3	Homo sapiens	119-124
27840668-2	2016	In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria.	Polyphenols	65-76	sirtuin 1	Homo sapiens	138-142
27840668-2	2016	In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria.	Polyphenols	95-106	sirtuin 3	Homo sapiens	119-124
27840668-5	2016	The other SIRT3-augmenting polyphenols tested also activated SOD2, suggesting antioxidant activity.	Polyphenols	27-38	sirtuin 3	Homo sapiens	10-15
28132448-4	2016	AMPK participation in the regulation of aging was indicated in the mechanisms dependent on: caloric restriction, mTOR, p53, sirtuins, autophagy, inflammation and the effects caused by polyphenols.	Polyphenols	184-195	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
26468275-0	2015	Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites.	Polyphenols	79-90	transthyretin	Homo sapiens	0-13
26730179-4	2016	Assessment of underlying mechanisms, especially in PC12 neuronal-like cells, reveals that direct agonistic effect on tropomyosin receptor kinase (Trk) receptors, the main receptors of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) explains the action of few polyphenols such as 7,8-dihydroxyflavone.	Polyphenols	313-324	nerve growth factor	Rattus norvegicus	215-234
26730179-4	2016	Assessment of underlying mechanisms, especially in PC12 neuronal-like cells, reveals that direct agonistic effect on tropomyosin receptor kinase (Trk) receptors, the main receptors of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) explains the action of few polyphenols such as 7,8-dihydroxyflavone.	Polyphenols	313-324	brain-derived neurotrophic factor	Rattus norvegicus	245-278
26730179-7	2016	Finally, the antioxidant activity of polyphenols reflected in the activation of Nrf2 pathway and the consequent upregulation of detoxification enzymes such as heme oxygenase-1 as well as the contribution of these effects to the neurotrophic activity have also been discussed.	Polyphenols	37-48	NFE2 like bZIP transcription factor 2	Rattus norvegicus	80-84
26730179-7	2016	Finally, the antioxidant activity of polyphenols reflected in the activation of Nrf2 pathway and the consequent upregulation of detoxification enzymes such as heme oxygenase-1 as well as the contribution of these effects to the neurotrophic activity have also been discussed.	Polyphenols	37-48	heme oxygenase 1	Rattus norvegicus	159-175
26468275-2	2015	The ability to inhibit TTR fibrillogenesis is known for several classes of compounds, including natural polyphenols, which protect the native state of TTR by specifically interacting with its thyroxine binding sites.	Polyphenols	104-115	transthyretin	Homo sapiens	23-26
26468275-2	2015	The ability to inhibit TTR fibrillogenesis is known for several classes of compounds, including natural polyphenols, which protect the native state of TTR by specifically interacting with its thyroxine binding sites.	Polyphenols	104-115	transthyretin	Homo sapiens	151-154
26468275-3	2015	Comparative analyses of the interaction and of the ability to protect the TTR native state for polyphenols, both stilbenoids and flavonoids, and some of their main metabolites have been carried out.	Polyphenols	95-106	transthyretin	Homo sapiens	74-77
26468275-9	2015	A rationale for the in vitro properties found for polyphenol metabolites was provided by x-ray analysis of their complexes with TTR.	Polyphenols	50-60	transthyretin	Homo sapiens	128-131
26498393-4	2015	Herein we report an in vitro inhibition study of human (h) CA isoforms hCAs I, II, IV, VII and XII with a panel of natural polyphenols including flavones, flavonols, flavanones, flavanols, isoflavones and depsides, some of which extracted from Quercus ilex and Salvia miltiorrhiza.	Polyphenols	123-134	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	71-90
26344851-0	2015	Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice.	Polyphenols	10-21	xanthine dehydrogenase	Mus musculus	56-72
26657338-0	2015	Reactivity of Metal-Free and Metal-Associated Amyloid-beta with Glycosylated Polyphenols and Their Esterified Derivatives.	Polyphenols	77-88	amyloid beta precursor protein	Homo sapiens	46-58
26657338-6	2015	Of the polyphenols investigated, the natural product (Verbascoside) and its esterified derivative (VPP) regulate the aggregation and cytotoxicity of metal-free and/or metal-associated Abeta to different extents.	Polyphenols	7-18	amyloid beta precursor protein	Homo sapiens	184-189
26397047-2	2015	Thus, we aimed to investigate the effect of polyphenol mixtures of Korean Euphorbia supina (PES) on the invasion and metastasis of highly metastatic breast cancer MDA-MB-231 cells.	Polyphenols	44-54	pescadillo ribosomal biogenesis factor 1	Homo sapiens	92-95
25976790-5	2015	Polyphenols can inhibit acrylamide formation through trapping of carbonyl compounds and preventing against lipid oxidation, while some special polyphenols can enhance the acrylamide content by providing carbonyl groups, accelerating the conversion from 3-aminopropionamide (3-APA) to acrylamide and inhibiting acrylamide elimination.	Polyphenols	0-11	glutamyl aminopeptidase	Homo sapiens	276-279
25976993-6	2015	The concentrations of polyphenols and flavonoids showed significant positive correlations with antioxidant activity as measured by DPPH, ABTS(+), and FRAP assays.	Polyphenols	22-33	mechanistic target of rapamycin kinase	Homo sapiens	150-154
26604687-0	2015	In silico approach for the discovery of new PPARgamma modulators among plant-derived polyphenols.	Polyphenols	85-96	peroxisome proliferator activated receptor gamma	Homo sapiens	44-53
26604687-4	2015	Based on recent evidence obtained with plant-derived polyphenols, the present in silico study aimed at finding new selective human PPARgamma (hPPARgamma) modulators that are able to improve glucose homeostasis with reduced side effects compared with TZDs.	Polyphenols	53-64	peroxisome proliferator activated receptor gamma	Homo sapiens	131-140
26604687-4	2015	Based on recent evidence obtained with plant-derived polyphenols, the present in silico study aimed at finding new selective human PPARgamma (hPPARgamma) modulators that are able to improve glucose homeostasis with reduced side effects compared with TZDs.	Polyphenols	53-64	peroxisome proliferator activated receptor gamma	Homo sapiens	142-152
25976790-5	2015	Polyphenols can inhibit acrylamide formation through trapping of carbonyl compounds and preventing against lipid oxidation, while some special polyphenols can enhance the acrylamide content by providing carbonyl groups, accelerating the conversion from 3-aminopropionamide (3-APA) to acrylamide and inhibiting acrylamide elimination.	Polyphenols	143-154	glutamyl aminopeptidase	Homo sapiens	276-279
26566306-0	2015	Dietary polyphenols increase fecal mucin and immunoglobulin A and ameliorate the disturbance in gut microbiota caused by a high fat diet.	Polyphenols	8-19	LOC100508689	Homo sapiens	35-40
26566306-4	2015	We demonstrated that dietary polyphenols derived from aronia, haskap, and bilberry, markedly elevated the amount of fecal mucin and immunoglobulin A (IgA) as an intestinal barrier function and ameliorated the disturbance in gut microbiota caused by a high fat diet in rats.	Polyphenols	29-40	LOC100508689	Homo sapiens	122-127
26440517-0	2015	Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity.	Polyphenols	5-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
26166229-6	2015	We found that several polyphenols exhibited the ability to increase Tfam promoter activity and that the soy isoflavone daidzein was a most potent candidate that regulated mitochondrial biogenesis.	Polyphenols	22-33	transcription factor A, mitochondrial	Mus musculus	68-72
26250940-0	2015	Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity.	Polyphenols	53-64	vascular endothelial growth factor A	Homo sapiens	80-84
26250940-0	2015	Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity.	Polyphenols	53-64	kinase insert domain receptor	Homo sapiens	93-100
26250940-3	2015	METHODS AND RESULTS: The concentration of polyphenol required to cause 50% inhibition (IC50 ) of VEGF-dependent VEGFR-2 activation in HUVECS was determined after pretreating VEGF with polyphenols at various concentations.	Polyphenols	42-52	vascular endothelial growth factor A	Homo sapiens	97-101
26250940-3	2015	METHODS AND RESULTS: The concentration of polyphenol required to cause 50% inhibition (IC50 ) of VEGF-dependent VEGFR-2 activation in HUVECS was determined after pretreating VEGF with polyphenols at various concentations.	Polyphenols	42-52	kinase insert domain receptor	Homo sapiens	112-119
26250940-3	2015	METHODS AND RESULTS: The concentration of polyphenol required to cause 50% inhibition (IC50 ) of VEGF-dependent VEGFR-2 activation in HUVECS was determined after pretreating VEGF with polyphenols at various concentations.	Polyphenols	42-52	vascular endothelial growth factor A	Homo sapiens	112-116
26250940-3	2015	METHODS AND RESULTS: The concentration of polyphenol required to cause 50% inhibition (IC50 ) of VEGF-dependent VEGFR-2 activation in HUVECS was determined after pretreating VEGF with polyphenols at various concentations.	Polyphenols	184-195	vascular endothelial growth factor A	Homo sapiens	97-101
26250940-3	2015	METHODS AND RESULTS: The concentration of polyphenol required to cause 50% inhibition (IC50 ) of VEGF-dependent VEGFR-2 activation in HUVECS was determined after pretreating VEGF with polyphenols at various concentations.	Polyphenols	184-195	kinase insert domain receptor	Homo sapiens	112-119
26250940-3	2015	METHODS AND RESULTS: The concentration of polyphenol required to cause 50% inhibition (IC50 ) of VEGF-dependent VEGFR-2 activation in HUVECS was determined after pretreating VEGF with polyphenols at various concentations.	Polyphenols	184-195	vascular endothelial growth factor A	Homo sapiens	112-116
26250940-8	2015	There was a strong correlation between potency of inhibition and binding affinities, and all polyphenols were predicted to bind to a region on VEGF involved in VEGFR-2 binding.	Polyphenols	93-104	vascular endothelial growth factor A	Homo sapiens	143-147
26250940-8	2015	There was a strong correlation between potency of inhibition and binding affinities, and all polyphenols were predicted to bind to a region on VEGF involved in VEGFR-2 binding.	Polyphenols	93-104	kinase insert domain receptor	Homo sapiens	160-167
26250940-9	2015	CONCLUSION: Specific polyphenols bind directly to a discrete region of VEGF and inhibit VEGF signalling, and this potentially explains the associations between consumption of these polyphenols and CVD risk.	Polyphenols	21-32	vascular endothelial growth factor A	Homo sapiens	71-75
26250940-9	2015	CONCLUSION: Specific polyphenols bind directly to a discrete region of VEGF and inhibit VEGF signalling, and this potentially explains the associations between consumption of these polyphenols and CVD risk.	Polyphenols	21-32	vascular endothelial growth factor A	Homo sapiens	88-92
26250940-9	2015	CONCLUSION: Specific polyphenols bind directly to a discrete region of VEGF and inhibit VEGF signalling, and this potentially explains the associations between consumption of these polyphenols and CVD risk.	Polyphenols	181-192	vascular endothelial growth factor A	Homo sapiens	71-75
26250940-9	2015	CONCLUSION: Specific polyphenols bind directly to a discrete region of VEGF and inhibit VEGF signalling, and this potentially explains the associations between consumption of these polyphenols and CVD risk.	Polyphenols	181-192	vascular endothelial growth factor A	Homo sapiens	88-92
26038095-9	2015	This may also occur with other polyphenols and ligands of beta-LG and gives not only important information for beta-LG binding studies, but may also apply for polymorphisms of other self-aggregating lipocalins.	Polyphenols	31-42	beta-lactoglobulin	Bos taurus	58-65
26603454-3	2015	Therefore, we hypothesized that polyphenol antioxidant resveratrol would mitigate oxidative stress, normalize renal AT1R signaling, and reduce BP in SHR.	Polyphenols	32-42	angiotensin II receptor, type 1a	Rattus norvegicus	116-120
26586942-0	2015	PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma.	Polyphenols	22-33	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	18-21
26586942-1	2015	The clinical success of the applicability of tea polyphenols awaits efficient systemic delivery and bioavailability.	Polyphenols	49-60	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	45-48
26586942-2	2015	Herein, following the concept of nanochemoprevention, which uses nanotechnology for enhancing the efficacy of chemotherapeutic drugs, we employed tea polyphenols, namely theaflavin (TF) and epigallocatechin-3-gallate (EGCG) encapsulated in a biodegradable nanoparticulate formulation based on poly(lactide-co-glycolide) (PLGA) with approximately 26% and 18% encapsulation efficiency, respectively.	Polyphenols	150-161	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	146-149
26529010-7	2015	In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and beta-catenin/T cell factor (Tcf)).	Polyphenols	28-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
26529010-7	2015	In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and beta-catenin/T cell factor (Tcf)).	Polyphenols	28-38	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	173-178
26529010-7	2015	In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and beta-catenin/T cell factor (Tcf)).	Polyphenols	28-38	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-199
26529010-7	2015	In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and beta-catenin/T cell factor (Tcf)).	Polyphenols	28-38	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	208-213
26529010-7	2015	In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and beta-catenin/T cell factor (Tcf)).	Polyphenols	28-38	nuclear factor kappa B subunit 1	Homo sapiens	283-292
26529010-7	2015	In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and beta-catenin/T cell factor (Tcf)).	Polyphenols	28-38	hepatocyte nuclear factor 4 alpha	Homo sapiens	298-324
26529010-7	2015	In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and beta-catenin/T cell factor (Tcf)).	Polyphenols	28-38	hepatocyte nuclear factor 4 alpha	Homo sapiens	326-329
25564337-2	2015	Here, three structurally related polyphenols found in the Chinese herb Huang Qui, namely baicalin, baicalein, and wogonin, were examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse.	Polyphenols	33-44	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	187-196
26322417-0	2015	The polyphenol PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages.	Polyphenols	4-14	scavenger receptor class B member 1	Homo sapiens	42-47
26322417-0	2015	The polyphenol PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages.	Polyphenols	4-14	ATP binding cassette subfamily A member 1	Homo sapiens	52-57
26322417-0	2015	The polyphenol PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages.	Polyphenols	4-14	GLI family zinc finger 2	Homo sapiens	70-75
26440517-4	2015	This study characterized effects of a subset of polyphenols on COX-2 expression and activity in vitro and compared the potency with known drugs.	Polyphenols	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
26440517-6	2015	Enzyme assays and incubations of polyphenols with the cancer cell line HCA-7 and lipopolysaccharide (LPS) stimulated primary monocytes support the hypothesis that polyphenols can effect COX-2 expression and activity in vitro.	Polyphenols	163-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
30090326-0	2016	Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways.	Polyphenols	9-19	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
26228682-8	2015	To understand these ostensibly contradictory results, a model of polyphenol:Abeta complexation was developed.	Polyphenols	65-75	histocompatibility 2, class II antigen A, beta 1	Mus musculus	76-81
27530003-0	2015	Role of AMP-activated Protein Kinase in NO- and EDHF-mediated Endothelium-dependent Relaxations to Red Wine Polyphenols.	Polyphenols	108-119	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	8-36
27530003-4	2015	The aim of the present study was to determine the role of the AMP-activated protein kinase (AMPK) in the red wine polyphenols (RWPs)-induced endothelial formation of NO and EDHF.	Polyphenols	114-125	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	62-90
27530003-4	2015	The aim of the present study was to determine the role of the AMP-activated protein kinase (AMPK) in the red wine polyphenols (RWPs)-induced endothelial formation of NO and EDHF.	Polyphenols	114-125	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	92-96
26231140-4	2015	In the resting neutrophils resveratrol and to lesser extent other polyphenols increased DNA damage and increased the level of p53.	Polyphenols	66-77	tumor protein p53	Homo sapiens	126-129
26334388-5	2015	The degree of apoptosis, as evaluated by Bid and Bcl-2 balance, was also suppressed after polyphenol treatment.	Polyphenols	90-100	BH3 interacting domain death agonist	Mus musculus	41-44
26333892-10	2015	Supplementation of TGF mice with a mixture of red grape polyphenols (50 mg/kg/d) for 4 wk improved mitochondrial function and highly decreased caspases activation, which allowed muscle atrophy mitigation.	Polyphenols	56-67	caspase 9	Mus musculus	143-151
26337017-12	2015	In conclusion, these results suggest that coffee polyphenol consumption improves postprandial hyperglycemia and vascular endothelial function, which is associated with increased GLP-1 secretion and decreased oxidative stress in healthy humans.	Polyphenols	49-59	glucagon	Homo sapiens	178-183
26235983-5	2015	We also identified brain-available polyphenol metabolites from BDPP, among which quercetin-3-O-glucuronide activates CREB signaling and malvidin-3-O-glucoside activates mTOR signaling.	Polyphenols	35-45	cAMP responsive element binding protein 1	Homo sapiens	117-121
26235983-5	2015	We also identified brain-available polyphenol metabolites from BDPP, among which quercetin-3-O-glucuronide activates CREB signaling and malvidin-3-O-glucoside activates mTOR signaling.	Polyphenols	35-45	mechanistic target of rapamycin kinase	Homo sapiens	169-173
26334388-5	2015	The degree of apoptosis, as evaluated by Bid and Bcl-2 balance, was also suppressed after polyphenol treatment.	Polyphenols	90-100	B cell leukemia/lymphoma 2	Mus musculus	49-54
28454959-0	2015	Mode of pancreatic lipase inhibition activity in vitro by some flavonoids and non-flavonoid polyphenols.	Polyphenols	92-103	pancreatic lipase	Homo sapiens	8-25
25999161-2	2015	METHODS: To identify new potential PARP-1 inhibitors, we performed a screening of a small-molecule library consisting of polyphenols isolated from plants used in the traditional medicine, by Surface Plasmon Resonance (SPR).	Polyphenols	121-132	poly(ADP-ribose) polymerase 1	Homo sapiens	35-41
28454959-4	2015	To elucidate the kinetic mode of PL inhibition, some selected flavonoid and non-flavonoid polyphenol standards were first screened for their lipase inhibition potency by their half maximal inhibitory concentration (IC50) followed by inhibition kinetic analysis.	Polyphenols	90-100	pancreatic lipase	Homo sapiens	33-35
26827537-8	2015	Compared with Hcy group, the proliferation, migration and the expression and activity of MMP-2/9 of VSMCs were significantly decreases in the VSMCs of polypeptides group, polyphenols group and Chinese yellow wine group.	Polyphenols	171-182	matrix metallopeptidase 2	Rattus norvegicus	89-96
25341848-0	2015	Comment on "Complex disruption effect of natural polyphenols on Bcl-2-Bax: molecular dynamics simulation and essential dynamics study" by S. Verma, A. Singh and A. Mishra.	Polyphenols	49-60	BCL2 apoptosis regulator	Homo sapiens	64-69
25341848-0	2015	Comment on "Complex disruption effect of natural polyphenols on Bcl-2-Bax: molecular dynamics simulation and essential dynamics study" by S. Verma, A. Singh and A. Mishra.	Polyphenols	49-60	BCL2 associated X, apoptosis regulator	Homo sapiens	70-73
26357462-0	2015	Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking.	Polyphenols	30-41	high mobility group AT-hook 1	Homo sapiens	61-65
26357462-3	2015	The present study was undertaken to observe different dietary polyphenols that can bind to the active site of HMGR and inhibit it.	Polyphenols	62-73	high mobility group AT-hook 1	Homo sapiens	110-114
26357462-4	2015	Results from the 12 dietary polyphenols tested reveal that polyphenols can bind to HMGR and block the binding of nicotinamide adenine dinucleotide phosphate (NADP(+)).	Polyphenols	28-39	high mobility group AT-hook 1	Homo sapiens	83-87
26357462-4	2015	Results from the 12 dietary polyphenols tested reveal that polyphenols can bind to HMGR and block the binding of nicotinamide adenine dinucleotide phosphate (NADP(+)).	Polyphenols	59-70	high mobility group AT-hook 1	Homo sapiens	83-87
26357462-10	2015	Therefore, this study substantiates the mechanism of polyphenols on the activity of HMGR by molecular docking and provides the impetus for drug design involving further structure-function relationship studies.	Polyphenols	53-64	high mobility group AT-hook 1	Homo sapiens	84-88
26246845-11	2015	RESULTS: Phenolic acids (i.e., gallic acid) and polyphenols (i.e., cyanidin) abundantly found in nature appeared to inhibit DGAT1 enzyme activity in vitro.	Polyphenols	48-59	diacylglycerol O-acyltransferase 1	Homo sapiens	124-129
26305254-0	2015	Apple Polyphenols Decrease Atherosclerosis and Hepatic Steatosis in ApoE-/- Mice through the ROS/MAPK/NF-kappaB Pathway.	Polyphenols	6-17	apolipoprotein E	Mus musculus	68-72
26305254-0	2015	Apple Polyphenols Decrease Atherosclerosis and Hepatic Steatosis in ApoE-/- Mice through the ROS/MAPK/NF-kappaB Pathway.	Polyphenols	6-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-111
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Polyphenols	168-178	keratin 20	Homo sapiens	90-94
26249340-3	2015	Here, structures of TTR in complex with three natural polyphenols (pterostilbene, quercetin and apigenin) have been determined, in which this asymmetry manifests itself as the presence of a main binding site with clear ligand occupancy and related electron density and a second minor site with a much lower ligand occupancy.	Polyphenols	54-65	transthyretin	Homo sapiens	20-23
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Polyphenols	168-178	immunglobulin heavy chain variable region	Homo sapiens	95-99
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Polyphenols	168-178	apolipoprotein A1	Homo sapiens	100-106
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Polyphenols	168-178	immunglobulin heavy chain variable region	Homo sapiens	210-214
25649257-0	2015	Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells.	Polyphenols	51-62	ubiquitin like modifier activating enzyme 7	Homo sapiens	42-47
25917043-13	2015	Polyphenols decrease membrane peroxidation and cytochrome c release from disks, preventing the induction of caspase-dependent apoptosis in the OS Such effects are relevant in the design of protection against functional impairment of the OS following oxidative stress from exposure to intense illumination.	Polyphenols	0-11	LOC104968582	Bos taurus	47-59
25649257-5	2015	Here, the effect of several chemopreventive polyphenols on UBE1L expression in human bronchial epithelial cells (Beas-2B) was investigated.	Polyphenols	44-55	ubiquitin like modifier activating enzyme 7	Homo sapiens	59-64
25649257-9	2015	Kinase inhibitors were used to examine the contribution of mitogen-activated protein kinase (MAPK) activity to the polyphenol-regulated UBE1L.	Polyphenols	115-125	ubiquitin like modifier activating enzyme 7	Homo sapiens	136-141
25649257-12	2015	It is concluded from the above mentioned results that JNK/Nrf2 signal pathway is involved in the regulation of UBE1L via intracellular ROS status when cells came in contact with polyphenols.	Polyphenols	178-189	mitogen-activated protein kinase 8	Homo sapiens	54-57
25649257-12	2015	It is concluded from the above mentioned results that JNK/Nrf2 signal pathway is involved in the regulation of UBE1L via intracellular ROS status when cells came in contact with polyphenols.	Polyphenols	178-189	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
25649257-12	2015	It is concluded from the above mentioned results that JNK/Nrf2 signal pathway is involved in the regulation of UBE1L via intracellular ROS status when cells came in contact with polyphenols.	Polyphenols	178-189	ubiquitin like modifier activating enzyme 7	Homo sapiens	111-116
26236179-3	2015	One of these detectors is AMPK (5" AMP-activated protein kinase), a protein kinase activated by ATP deficiency but also by several natural substances such as polyphenols or synthetic molecules like metformin, used in the treatment of insulin resistance.	Polyphenols	158-169	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	26-30
25808216-11	2015	CONCLUSION: Resveratrol improves peripheral insulin signaling independently of Sirt1 in diabetic mice in association with the inhibition of PTP1B and, therefore, this polyphenol could be an effective adjuvant for the treatment of diabetes.	Polyphenols	167-177	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	140-145
26382171-1	2015	The hepatoprotective and nephroprotective activity of a polyphenol-rich fraction (BHPF) obtained from Bauhinia hookeri was investigated against CCl4-induced acute hepatorenal toxicity in mice.	Polyphenols	56-66	chemokine (C-C motif) ligand 4	Mus musculus	144-148
26042469-0	2015	Effect of Natural Polyphenols on CYP Metabolism: Implications for Diseases.	Polyphenols	18-29	peptidylprolyl isomerase G	Homo sapiens	33-36
26042469-5	2015	Extensive experimental data collected over the past decade point at the active role of natural polyphenols in modulating the catalytic activity of CYP.	Polyphenols	95-106	peptidylprolyl isomerase G	Homo sapiens	147-150
26042469-8	2015	The polyphenol-CYP interactions may significantly alter the pharmacokinetics of drugs and thus influence the effectiveness of chemical therapies used in the treatment of different types of cancers, diabetes, obesity, and cardiovascular diseases (CVD).	Polyphenols	4-14	peptidylprolyl isomerase G	Homo sapiens	15-18
26042469-15	2015	Thus, polyphenol-mediated modulation of the CYP"s activity also plays a vital role in estrogen carcinogenesis.	Polyphenols	6-16	peptidylprolyl isomerase G	Homo sapiens	44-47
26042469-16	2015	The aim of the present review is to summarize the data collected over the last five to six years on the following topics: (1) the mechanisms of the interactions of CYP with food constituents that occur via the direct binding of polyphenols to the enzymes and (2) the mechanisms of the regulation of CYP gene expression mediated by polyphenols.	Polyphenols	228-239	peptidylprolyl isomerase G	Homo sapiens	164-167
26042469-16	2015	The aim of the present review is to summarize the data collected over the last five to six years on the following topics: (1) the mechanisms of the interactions of CYP with food constituents that occur via the direct binding of polyphenols to the enzymes and (2) the mechanisms of the regulation of CYP gene expression mediated by polyphenols.	Polyphenols	228-239	peptidylprolyl isomerase G	Homo sapiens	299-302
26042469-16	2015	The aim of the present review is to summarize the data collected over the last five to six years on the following topics: (1) the mechanisms of the interactions of CYP with food constituents that occur via the direct binding of polyphenols to the enzymes and (2) the mechanisms of the regulation of CYP gene expression mediated by polyphenols.	Polyphenols	331-342	peptidylprolyl isomerase G	Homo sapiens	164-167
26042469-17	2015	The structure-activity relationship relevant to the ability of polyphenols to affect the activity of CYP is analyzed.	Polyphenols	63-74	peptidylprolyl isomerase G	Homo sapiens	101-104
26042469-18	2015	The application of polyphenol-CYP interactions to diseases is discussed.	Polyphenols	19-29	peptidylprolyl isomerase G	Homo sapiens	30-33
25881741-0	2015	Cystic fibrosis transmembrane conductance regulator is involved in polyphenol-induced swelling of the endothelial glycocalyx.	Polyphenols	67-77	CF transmembrane conductance regulator	Bos taurus	0-51
25881741-3	2015	As polyphenols are potent modulators of fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel, the hypothesis was tested whether polyphenol-induced increase in CFTR activity is responsible for the eGC-swelling.	Polyphenols	3-14	CF transmembrane conductance regulator	Bos taurus	86-90
25881741-3	2015	As polyphenols are potent modulators of fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel, the hypothesis was tested whether polyphenol-induced increase in CFTR activity is responsible for the eGC-swelling.	Polyphenols	3-13	CF transmembrane conductance regulator	Bos taurus	86-90
25881741-8	2015	Thus, in the vascular endothelium, polyphenols induce eGC-swelling by softening cortical actin and activating CFTR.	Polyphenols	35-46	CF transmembrane conductance regulator	Bos taurus	110-114
25881741-9	2015	Our findings imply that CFTR plays an important role in the maintenance of vascular homeostasis and may explain the vasoprotective properties of polyphenols.	Polyphenols	145-156	CF transmembrane conductance regulator	Bos taurus	24-28
26783841-5	2015	However, only the extractable fraction was studied in UHT milk, which was characterized by a small amount of polyphenols.	Polyphenols	109-120	Weaning weight-maternal milk	Bos taurus	58-62
26236179-3	2015	One of these detectors is AMPK (5" AMP-activated protein kinase), a protein kinase activated by ATP deficiency but also by several natural substances such as polyphenols or synthetic molecules like metformin, used in the treatment of insulin resistance.	Polyphenols	158-169	insulin	Homo sapiens	234-241
26044037-0	2015	Identification of Black Bean (Phaseolus vulgaris L.) Polyphenols That Inhibit and Promote Iron Uptake by Caco-2 Cells.	Polyphenols	53-64	brain expressed associated with NEDD4 1	Homo sapiens	24-28
26214449-4	2015	Additionally, UV-C irradiation induced the transcription of Vv lar1 and Vv lar2 and the synthesis of LAR1 and LAR2 proteins, resulting in increased accumulation of flavanol polyphenol in the grape berry.	Polyphenols	173-183	leucoanthocyanidin reductase 1	Vitis vinifera	101-105
26214449-4	2015	Additionally, UV-C irradiation induced the transcription of Vv lar1 and Vv lar2 and the synthesis of LAR1 and LAR2 proteins, resulting in increased accumulation of flavanol polyphenol in the grape berry.	Polyphenols	173-183	leucoanthocyanidin reductase 2	Vitis vinifera	110-114
26044037-4	2015	Analysis of seed coat extracts by LC-MS revealed the presence of a range of polyphenols in black bean, but no detectable polyphenols in white bean.	Polyphenols	76-87	brain expressed associated with NEDD4 1	Homo sapiens	97-101
26044037-8	2015	The ability of some polyphenols to promote iron uptake and the identification of specific polyphenols that inhibit Fe uptake suggest a potential for breeding bean lines with improved iron nutritional qualities.	Polyphenols	20-31	brain expressed associated with NEDD4 1	Homo sapiens	158-162
26044037-8	2015	The ability of some polyphenols to promote iron uptake and the identification of specific polyphenols that inhibit Fe uptake suggest a potential for breeding bean lines with improved iron nutritional qualities.	Polyphenols	90-101	brain expressed associated with NEDD4 1	Homo sapiens	158-162
26132857-8	2015	One of the most important sources of potential pancreatic lipase inhibitors represents the class of polyphenols.	Polyphenols	100-111	pancreatic lipase	Homo sapiens	47-64
26139922-0	2015	Comparative inhibitory potential of selected dietary bioactive polyphenols, phytosterols on CYP3A4 and CYP2D6 with fluorometric high-throughput screening.	Polyphenols	63-74	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	103-109
26132857-9	2015	This article summarizes most studied subclasses of polyphenols including flavonoids, hydroxycinnamic acids, hydroxybenzoic acids and lignans with pancreatic lipase inhibitory effects.	Polyphenols	51-62	pancreatic lipase	Homo sapiens	146-163
26043379-7	2015	A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme.	Polyphenols	43-53	interleukin 6	Homo sapiens	116-129
26100408-0	2015	Vanda roxburghii chloroform extract as a potential source of polyphenols with antioxidant and cholinesterase inhibitory activities: identification of a strong phenolic antioxidant.	Polyphenols	61-72	butyrylcholinesterase	Homo sapiens	94-108
26092868-2	2015	Studies have suggested activating effects of resveratrol, a naturally-occurring polyphenol compound with antioxidant and anti-inflammatory properties, on CF transmembrane conductance regulator (CFTR) protein function.	Polyphenols	80-90	cystic fibrosis transmembrane conductance regulator	Mus musculus	154-192
26092868-2	2015	Studies have suggested activating effects of resveratrol, a naturally-occurring polyphenol compound with antioxidant and anti-inflammatory properties, on CF transmembrane conductance regulator (CFTR) protein function.	Polyphenols	80-90	cystic fibrosis transmembrane conductance regulator	Mus musculus	194-198
26043379-7	2015	A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme.	Polyphenols	43-53	interleukin 6	Homo sapiens	131-135
26043379-7	2015	A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme.	Polyphenols	43-53	tumor necrosis factor	Homo sapiens	168-177
26043379-7	2015	A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme.	Polyphenols	43-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	206-222
26043379-7	2015	A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme.	Polyphenols	43-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	224-229
25727173-8	2015	Our findings demonstrate prevention by RSV of ischemia-induced reduction of GLT-1 expression in the vulnerable CA1 layer 7 days following global ischemia, which was accompanied by the polyphenol"s inhibition of post ischemic increase in CD11b/c and GFAP expression.	Polyphenols	184-194	solute carrier family 1 member 2	Rattus norvegicus	76-81
26177907-0	2015	Green Tea Polyphenols Attenuate High-Fat Diet-Induced Renal Oxidative Stress through SIRT3-Dependent Deacetylation.	Polyphenols	10-21	sirtuin 3	Rattus norvegicus	85-90
24481780-0	2015	Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells.	Polyphenols	84-95	TIMP metallopeptidase inhibitor 3	Homo sapiens	24-70
24481780-2	2015	In the present study, we demonstrate that green tea polyphenols (GTP) and its major constituent, epigallocatechin-3-gallate (EGCG) mediate epigenetic induction of TIMP-3 levels and play a key role in suppressing invasiveness and gelatinolytic activity of MMP-2 and MMP-9 in breast cancer cells.	Polyphenols	52-63	TIMP metallopeptidase inhibitor 3	Homo sapiens	163-169
24481780-2	2015	In the present study, we demonstrate that green tea polyphenols (GTP) and its major constituent, epigallocatechin-3-gallate (EGCG) mediate epigenetic induction of TIMP-3 levels and play a key role in suppressing invasiveness and gelatinolytic activity of MMP-2 and MMP-9 in breast cancer cells.	Polyphenols	52-63	matrix metallopeptidase 2	Homo sapiens	255-260
24481780-2	2015	In the present study, we demonstrate that green tea polyphenols (GTP) and its major constituent, epigallocatechin-3-gallate (EGCG) mediate epigenetic induction of TIMP-3 levels and play a key role in suppressing invasiveness and gelatinolytic activity of MMP-2 and MMP-9 in breast cancer cells.	Polyphenols	52-63	matrix metallopeptidase 9	Homo sapiens	265-270
25929447-0	2015	Ellagic Acid, a Dietary Polyphenol, Inhibits Tautomerase Activity of Human Macrophage Migration Inhibitory Factor and Its Pro-inflammatory Responses in Human Peripheral Blood Mononuclear Cells.	Polyphenols	24-34	macrophage migration inhibitory factor	Homo sapiens	75-113
25727173-8	2015	Our findings demonstrate prevention by RSV of ischemia-induced reduction of GLT-1 expression in the vulnerable CA1 layer 7 days following global ischemia, which was accompanied by the polyphenol"s inhibition of post ischemic increase in CD11b/c and GFAP expression.	Polyphenols	184-194	carbonic anhydrase 1	Rattus norvegicus	111-114
25727173-8	2015	Our findings demonstrate prevention by RSV of ischemia-induced reduction of GLT-1 expression in the vulnerable CA1 layer 7 days following global ischemia, which was accompanied by the polyphenol"s inhibition of post ischemic increase in CD11b/c and GFAP expression.	Polyphenols	184-194	integrin subunit alpha M	Rattus norvegicus	237-242
25727173-8	2015	Our findings demonstrate prevention by RSV of ischemia-induced reduction of GLT-1 expression in the vulnerable CA1 layer 7 days following global ischemia, which was accompanied by the polyphenol"s inhibition of post ischemic increase in CD11b/c and GFAP expression.	Polyphenols	184-194	glial fibrillary acidic protein	Rattus norvegicus	249-253
25940564-12	2015	TTR-induced cytotoxicity was inhibited by resveratrol, a plant polyphenol that stabilizes the native tetrameric structure of TTR.	Polyphenols	63-73	transthyretin	Homo sapiens	0-3
25725373-2	2015	We have shown previously that the combinations of green tea polyphenols (GTPs), a dietary DNA methyltransferase inhibitor, and sulforaphane (SFN), a dietary histone deacetylase inhibitor, reactivate ERalpha expression in ERalpha-negative MDA-MB-231 cells.	Polyphenols	60-71	estrogen receptor 1	Homo sapiens	199-206
25725373-2	2015	We have shown previously that the combinations of green tea polyphenols (GTPs), a dietary DNA methyltransferase inhibitor, and sulforaphane (SFN), a dietary histone deacetylase inhibitor, reactivate ERalpha expression in ERalpha-negative MDA-MB-231 cells.	Polyphenols	60-71	estrogen receptor 1	Homo sapiens	221-228
25967609-12	2015	Black seeds extract inhibited amyloid progression of insulin via ROS scavenging and restrained the cytotoxicity caused by insulin fibrils suggesting black seeds containing polyphenols may serve as a lead structure to a novel anti-amyloidogenic drugs.	Polyphenols	172-183	insulin	Homo sapiens	53-60
25967609-12	2015	Black seeds extract inhibited amyloid progression of insulin via ROS scavenging and restrained the cytotoxicity caused by insulin fibrils suggesting black seeds containing polyphenols may serve as a lead structure to a novel anti-amyloidogenic drugs.	Polyphenols	172-183	insulin	Homo sapiens	122-129
25940564-12	2015	TTR-induced cytotoxicity was inhibited by resveratrol, a plant polyphenol that stabilizes the native tetrameric structure of TTR.	Polyphenols	63-73	transthyretin	Homo sapiens	125-128
25836918-2	2015	An alternative hypothesis that is gaining considerable traction is that (poly)phenols are processed by the body as xenobiotics via the Keap1/Nrf2/ARE signaling axis, leading to the induction of Phase II enzymes.	Polyphenols	72-85	kelch like ECH associated protein 1	Homo sapiens	135-140
25845763-2	2015	Resveratrol is a naturally occurring polyphenol, identified to increase frataxin expression in cellular and mouse models of FRDA and has anti-oxidant properties.	Polyphenols	37-47	frataxin	Mus musculus	72-80
25845763-2	2015	Resveratrol is a naturally occurring polyphenol, identified to increase frataxin expression in cellular and mouse models of FRDA and has anti-oxidant properties.	Polyphenols	37-47	frataxin	Mus musculus	124-128
25836918-2	2015	An alternative hypothesis that is gaining considerable traction is that (poly)phenols are processed by the body as xenobiotics via the Keap1/Nrf2/ARE signaling axis, leading to the induction of Phase II enzymes.	Polyphenols	72-85	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
25267105-2	2015	The polyphenol (+)-episesamin (ES) was shown to counteract TNF-alpha-induced effects, for example in macrophages.	Polyphenols	4-14	tumor necrosis factor	Homo sapiens	59-68
25898131-6	2015	Using a clinically relevant mouse model of residual PC, we use tissue microarray (TMA) and immunohistochemistry (IHC) procedures to investigate the potential of polyphenol(s) to target ATG3, ATG5, ATG12, LC3A, LC3B, BECN1, and SURIVIN after clinical radiotherapy.	Polyphenols	161-171	autophagy related 3	Mus musculus	185-189
25898131-6	2015	Using a clinically relevant mouse model of residual PC, we use tissue microarray (TMA) and immunohistochemistry (IHC) procedures to investigate the potential of polyphenol(s) to target ATG3, ATG5, ATG12, LC3A, LC3B, BECN1, and SURIVIN after clinical radiotherapy.	Polyphenols	161-171	autophagy related 12	Mus musculus	197-202
25769517-6	2015	Other natural compounds, like polyphenols or indolic molecules such as melatonin, can interfere with beta-amyloid peptide pathogenicity by inhibiting aggregation and counteracting oxidative stress that is a key hallmark in Alzheimer"s disease.	Polyphenols	30-41	amyloid beta precursor protein	Homo sapiens	101-121
24826916-6	2015	The present review focuses on the chemistry of polyphenols and their role in modulating amyloid precursor protein (APP) processing.	Polyphenols	47-58	amyloid beta precursor protein	Homo sapiens	88-113
24898689-10	2015	The mode of action of NaCl and NaF is through decreasing PPO activity resulting in reduced oxidation of polyphenols.	Polyphenols	104-115	polyphenol oxidase, chloroplastic	Malus domestica	57-60
25811373-9	2015	Polyphenol-containing extracts of P. igniarius were then used to prevent acrolein toxicity in a mouse neuroblastoma (Neuro-2a) cell line.	Polyphenols	0-10	Rho guanine nucleotide exchange factor (GEF) 16	Mus musculus	102-115
25798826-5	2015	Here, we evaluated the chemical basis of the resveratrol-mediated activation of PPARalpha by performing a docking mode simulation and examining the structure-activity relationships of various polyphenols.	Polyphenols	192-203	peroxisome proliferator activated receptor alpha	Mus musculus	80-89
25466060-4	2015	The least degradation of beta-carotene occurred in the emulsion stabilised with the alpha-La-EGCG covalent complex when stored at 25  C. These results implied that protein-polyphenol covalent complexes were able to enhance the physical stability of beta-carotene emulsion and inhibit the degradation of beta-carotene in oil-in-water emulsion, and the effect was influenced by the types of the phenolic compounds.	Polyphenols	172-182	lactalbumin alpha	Homo sapiens	84-92
25824377-5	2015	Here, we revealed the polyphenol eriodictyol significantly potentiated apoptosis induction by EGCG in vitro and in a mouse tumour model by amplifying EGCG-induced activation of the 67-kDa laminin receptor (67LR)/protein kinase B/endothelial nitric oxide synthase/protein kinase C delta/acid sphingomyelinase signalling pathway.	Polyphenols	22-32	ribosomal protein SA	Mus musculus	181-204
25824377-5	2015	Here, we revealed the polyphenol eriodictyol significantly potentiated apoptosis induction by EGCG in vitro and in a mouse tumour model by amplifying EGCG-induced activation of the 67-kDa laminin receptor (67LR)/protein kinase B/endothelial nitric oxide synthase/protein kinase C delta/acid sphingomyelinase signalling pathway.	Polyphenols	22-32	ribosomal protein SA	Mus musculus	206-210
25824377-5	2015	Here, we revealed the polyphenol eriodictyol significantly potentiated apoptosis induction by EGCG in vitro and in a mouse tumour model by amplifying EGCG-induced activation of the 67-kDa laminin receptor (67LR)/protein kinase B/endothelial nitric oxide synthase/protein kinase C delta/acid sphingomyelinase signalling pathway.	Polyphenols	22-32	nitric oxide synthase 3, endothelial cell	Mus musculus	229-262
25824377-5	2015	Here, we revealed the polyphenol eriodictyol significantly potentiated apoptosis induction by EGCG in vitro and in a mouse tumour model by amplifying EGCG-induced activation of the 67-kDa laminin receptor (67LR)/protein kinase B/endothelial nitric oxide synthase/protein kinase C delta/acid sphingomyelinase signalling pathway.	Polyphenols	22-32	protein kinase C, delta	Mus musculus	263-285
26097706-0	2015	Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 (GLP-1(7-36)) amide in C57BL/6J mice.	Polyphenols	20-31	glucagon	Mus musculus	102-107
25694723-2	2015	Milk is one of the important carrier which has been effectively used to deliver phytochemicals presents in herbs (mainly polyphenols) for targeted health benefits in the traditional Indian system of medical science.	Polyphenols	121-132	Weaning weight-maternal milk	Bos taurus	0-4
25319353-4	2015	In this study, SMN2-inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients.	Polyphenols	73-83	survival of motor neuron 2, centromeric	Homo sapiens	15-19
25546248-2	2015	The aim of this study was to determine the molecular mechanism underlying the potent inhibition of VEGF signalling by polyphenols.	Polyphenols	118-129	vascular endothelial growth factor A	Homo sapiens	99-103
25546248-4	2015	The polyphenol-induced inhibition of VEGF-induced VEGFR-2 activation occurred at nanomolar polyphenol concentrations and followed bi-phasic inhibition kinetics.	Polyphenols	4-14	vascular endothelial growth factor A	Homo sapiens	37-41
25546248-4	2015	The polyphenol-induced inhibition of VEGF-induced VEGFR-2 activation occurred at nanomolar polyphenol concentrations and followed bi-phasic inhibition kinetics.	Polyphenols	4-14	kinase insert domain receptor	Homo sapiens	50-57
25546248-4	2015	The polyphenol-induced inhibition of VEGF-induced VEGFR-2 activation occurred at nanomolar polyphenol concentrations and followed bi-phasic inhibition kinetics.	Polyphenols	91-101	vascular endothelial growth factor A	Homo sapiens	37-41
25546248-4	2015	The polyphenol-induced inhibition of VEGF-induced VEGFR-2 activation occurred at nanomolar polyphenol concentrations and followed bi-phasic inhibition kinetics.	Polyphenols	91-101	kinase insert domain receptor	Homo sapiens	50-57
25546248-5	2015	VEGF activity could not be recovered by dialysing VEGF-polyphenol complexes.	Polyphenols	55-65	vascular endothelial growth factor A	Homo sapiens	0-4
25546248-7	2015	Remarkably, even though VEGFR-2 signalling was completely inhibited at 1 muM concentrations of polyphenols, endothelial nitric oxide synthase was shown to still be activated via the PI3K/Akt signalling pathway which is downstream of VEGFR-2.	Polyphenols	95-106	kinase insert domain receptor	Homo sapiens	24-31
25546248-8	2015	CONCLUSION: These data demonstrate for the first time that VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.	Polyphenols	103-114	vascular endothelial growth factor A	Homo sapiens	59-63
25546248-8	2015	CONCLUSION: These data demonstrate for the first time that VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.	Polyphenols	103-114	vascular endothelial growth factor A	Homo sapiens	169-173
25498223-0	2015	Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral alpha-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
25498223-0	2015	Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral alpha-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys.	Polyphenols	4-15	synuclein alpha	Homo sapiens	88-103
25498223-1	2015	Tea polyphenols (TPs) are bioactive flavanol-related catechins that have been shown to protect dopaminergic (DAergic) neurons against neurotoxin-induced injury in mouse Parkinson"s disease (PD) models.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
25679229-3	2015	A major constraint to bean iron biofortification is low iron absorption, attributed to inhibitory compounds such as phytic acid (PA) and polyphenol(s) (PP).	Polyphenols	137-150	brain expressed associated with NEDD4 1	Homo sapiens	22-26
25650313-0	2015	Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease.	Polyphenols	20-30	N-methylpurine DNA glycosylase	Homo sapiens	78-108
25663929-3	2015	Polyphenols have demonstrated potential in reducing the risk of developing numerous types of cancer, as well reducing the risk of cancer progression, due to their ability to reduce cell viability and vascular endothelial growth factor (VEGF) expression.	Polyphenols	0-11	vascular endothelial growth factor A	Homo sapiens	200-234
25663929-3	2015	Polyphenols have demonstrated potential in reducing the risk of developing numerous types of cancer, as well reducing the risk of cancer progression, due to their ability to reduce cell viability and vascular endothelial growth factor (VEGF) expression.	Polyphenols	0-11	vascular endothelial growth factor A	Homo sapiens	236-240
25710724-0	2015	Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf.	Polyphenols	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
25492718-0	2015	Differential protective effects of polyphenol extracts from apple peels and fleshes against acute CCl4-induced liver damage in mice.	Polyphenols	35-45	chemokine (C-C motif) ligand 4	Mus musculus	98-102
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Polyphenols	10-21	leptin	Rattus norvegicus	133-139
25479240-0	2015	Brown Alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress, and inflammation by activation of AMPK and SIRT1 in high-fat diet-induced obese mice.	Polyphenols	25-35	sirtuin 1	Mus musculus	138-143
25612477-5	2015	Accumulating body of evidence have shown that resveratrol, a natural polyphenol in grapes and red wine, activates the longevity-related protein sirtuin 1 (SIRT1) and augments insulin sensitivity in addition to its well-documented effects on mitochondrial energetics.	Polyphenols	69-79	sirtuin 1	Homo sapiens	144-153
25612477-5	2015	Accumulating body of evidence have shown that resveratrol, a natural polyphenol in grapes and red wine, activates the longevity-related protein sirtuin 1 (SIRT1) and augments insulin sensitivity in addition to its well-documented effects on mitochondrial energetics.	Polyphenols	69-79	sirtuin 1	Homo sapiens	155-160
25174925-3	2015	Sea buckthorn berries, red grapes, bilberries, chokeberries and popular drinks like cocoa, coffee and green tea are all rich in polyphenols and may decrease the insulin response, offer in g a natural alternative of treatment in diabetes.	Polyphenols	128-139	insulin	Homo sapiens	161-168
25174925-5	2015	Animal and human studies showed that polyphenols modulate carbohydrate and lipid metabolism, decrease glycemia and insulin resistance, increase lipid metabolism and optimize oxidative stress and inflammatory processes.	Polyphenols	37-48	insulin	Homo sapiens	115-122
25665579-5	2015	Additionally, polyphenols may increase antioxidative defense in normal cells by increasing the activity of NRF2, transcription factor for many protective proteins.	Polyphenols	14-25	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
26415702-0	2015	The modulation of carbonyl reductase 1 by polyphenols.	Polyphenols	42-53	carbonyl reductase 1	Homo sapiens	18-38
26415702-8	2015	Some polyphenols (e.g. luteolin, apigenin and curcumin) have been shown to be very potent CBR1 inhibitors.	Polyphenols	5-16	carbonyl reductase 1	Homo sapiens	90-94
26415702-10	2015	Nevertheless, all known information about the interactions of polyphenols with CBR1 have only been based on the results of in vitro studies.	Polyphenols	62-73	carbonyl reductase 1	Homo sapiens	79-83
26347785-0	2015	ERK1/2 and HIF1alpha Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis.	Polyphenols	62-73	mitogen activated protein kinase 3	Rattus norvegicus	0-6
26347785-0	2015	ERK1/2 and HIF1alpha Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis.	Polyphenols	62-73	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	11-20
25329972-0	2015	Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling.	Polyphenols	51-61	sirtuin 3	Homo sapiens	157-166
25531836-3	2015	Resveratrol, a natural polyphenol, has been reported to inhibit amyloid formation by IAPP and by the Alzheimer"s disease Abeta peptide.	Polyphenols	23-33	islet amyloid polypeptide	Homo sapiens	85-89
26783228-0	2015	TNF-alpha and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation.	Polyphenols	42-53	tumor necrosis factor	Mus musculus	0-9
26783228-0	2015	TNF-alpha and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation.	Polyphenols	42-53	interleukin 10	Mus musculus	14-19
26783228-3	2015	administration of a blend of olive (Olea europaea L.) polyphenols (10 mg/kg) containing mostly hydroxytyrosol could have an effect on cytokines playing important roles in inflammatory processes as TNF-alpha and IL-10.	Polyphenols	54-65	tumor necrosis factor	Mus musculus	197-206
26783228-3	2015	administration of a blend of olive (Olea europaea L.) polyphenols (10 mg/kg) containing mostly hydroxytyrosol could have an effect on cytokines playing important roles in inflammatory processes as TNF-alpha and IL-10.	Polyphenols	54-65	interleukin 10	Mus musculus	211-216
26783228-7	2015	As for TNF-alpha, our findings did not reveal differences between groups but an increase in the polyphenol and carrageenan group if compared to the carrageenan only group.	Polyphenols	96-106	tumor necrosis factor	Mus musculus	7-16
26783228-9	2015	CONCLUSIONS: Altogether, this investigation shows that olive polyphenols in the mouse may modulate the levels of cytokines having a role in the process of inflammation as TNF-alpha and IL-10.	Polyphenols	61-72	tumor necrosis factor	Mus musculus	171-180
26783228-9	2015	CONCLUSIONS: Altogether, this investigation shows that olive polyphenols in the mouse may modulate the levels of cytokines having a role in the process of inflammation as TNF-alpha and IL-10.	Polyphenols	61-72	interleukin 10	Mus musculus	185-190
26155176-3	2015	Nontoxic tea polyphenols are potent antioxidants, and they also modulate several signalling pathways and inhibit proteins such as MMP-9 or protein plasminogen activator system, making them very attractive potential therapeutics.	Polyphenols	13-24	matrix metallopeptidase 9	Homo sapiens	130-135
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	interleukin 1 beta	Homo sapiens	101-109
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	C-C motif chemokine ligand 2	Homo sapiens	117-122
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	nitric oxide synthase 2	Homo sapiens	133-137
25878716-5	2015	Fractionation of these extracts potentiated the anti-TNF-alpha effect, which was shown to concentrate in polar fractions, mainly composed by polyphenols.	Polyphenols	141-152	tumor necrosis factor	Homo sapiens	53-62
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Polyphenols	10-21	interleukin 6	Rattus norvegicus	236-240
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Polyphenols	10-21	tumor necrosis factor	Rattus norvegicus	245-254
25431018-5	2015	Furthermore, it was shown that polysaccharides and polyphenols were synergistic in reduction of serum leptin levels and in anti-inflammatory activity.	Polyphenols	51-62	leptin	Rattus norvegicus	102-108
25589732-3	2015	In the present study, we identified a natural polyphenol, luteolin, as a potent inhibitor of BACE1 transcription inhuman embryonic kidney 293 (HEK293) and human neuroblastoma (SH-SY5Y) cell lines.	Polyphenols	46-56	beta-secretase 1	Homo sapiens	93-98
24903407-0	2015	Complex disruption effect of natural polyphenols on Bcl-2-Bax: molecular dynamics simulation and essential dynamics study.	Polyphenols	37-48	BCL2 apoptosis regulator	Homo sapiens	52-57
24903407-0	2015	Complex disruption effect of natural polyphenols on Bcl-2-Bax: molecular dynamics simulation and essential dynamics study.	Polyphenols	37-48	BCL2 associated X, apoptosis regulator	Homo sapiens	58-61
24903407-4	2015	Quercetin and taxifolin (natural polyphenols) efficiently bound to hydrophobic groove of Bcl-2 and altered the structure by inducing conformational changes.	Polyphenols	33-44	BCL2 apoptosis regulator	Homo sapiens	89-94
26180597-7	2015	This review focuses on interactions between dietary polyphenols and CYP3A4 as they relate to structural considerations, food-drug interactions, and potential negative consequences of interactions between CYP3A4 and polyphenols.	Polyphenols	215-226	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-74
25466651-3	2015	In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production.	Polyphenols	40-51	endothelin 1	Homo sapiens	97-109
25466651-3	2015	In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production.	Polyphenols	40-51	endothelin 1	Homo sapiens	111-115
25466651-5	2015	The effects of polyphenols on ECs include antioxidant activity and enhancement of the expression of several protective proteins, including endothelial nitric oxide synthase and paraoxonase 1.	Polyphenols	15-26	paraoxonase 1	Homo sapiens	177-190
26180597-0	2015	Interactions between CYP3A4 and Dietary Polyphenols.	Polyphenols	40-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-27
26180597-7	2015	This review focuses on interactions between dietary polyphenols and CYP3A4 as they relate to structural considerations, food-drug interactions, and potential negative consequences of interactions between CYP3A4 and polyphenols.	Polyphenols	52-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	204-210
25314656-0	2015	Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide.	Polyphenols	0-11	reticulon 4	Homo sapiens	62-68
25314656-0	2015	Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide.	Polyphenols	0-11	ribosomal protein SA	Homo sapiens	73-96
25314656-3	2015	In this study, using nerve growth factor-differentiated neuronal-like Neuroscreen-1 cells, we show that extremely low concentrations of unfractionated green tea polyphenol mixture (GTPP) and its active ingredient, epigallocatechin-3-gallate (EGCG), prevent both the neurite outgrowth-inhibiting activity and growth cone-collapsing activity of Nogo-66 (C-terminal domain of Nogo-A).	Polyphenols	161-171	reticulon 4	Homo sapiens	373-379
25314656-11	2015	Epigallocatechin-3-gallate (EGCG), present in green tea polyphenol mixture (GTPP), prevents antineuritogenic activity of Nogo-A, a myelin-derived axonal growth inhibitor.	Polyphenols	56-66	reticulon 4	Homo sapiens	121-127
25589236-0	2015	Simultaneous ultrasound-assisted water extraction and beta-cyclodextrin encapsulation of polyphenols from Mangifera indica stem bark in counteracting TNFalpha-induced endothelial dysfunction.	Polyphenols	89-100	tumor necrosis factor	Homo sapiens	150-158
26236423-2	2015	In this study, we newly described the efficacy of a number of dietary antioxidants (polyphenols, carotenoids, thiolic compounds, and oligoelements) on viability of neuronal PC12 cells following Nerve Growth Factor (NGF) deprivation, a model of age-related decrease of neurotrophic support that triggers neuronal loss.	Polyphenols	84-95	nerve growth factor	Rattus norvegicus	194-213
25766656-3	2015	Although polyphenols can induce MnSOD expression, their mechanism of action remains unclear.	Polyphenols	9-20	superoxide dismutase 2	Homo sapiens	32-37
25498967-3	2015	It has been shown that many polyphenols gain their beneficial properties (e.g. cancer prevention) through the activation of the Nrf2/Keap1 pathway as well as their direct antioxidant activity.	Polyphenols	28-39	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
25498967-3	2015	It has been shown that many polyphenols gain their beneficial properties (e.g. cancer prevention) through the activation of the Nrf2/Keap1 pathway as well as their direct antioxidant activity.	Polyphenols	28-39	kelch like ECH associated protein 1	Homo sapiens	133-138
24500372-1	2014	PURPOSE: The consumption of a high level of dietary extract from blackcurrant pomace rich in polyphenols was hypothesised to exert beneficial effects on the serum lipid profile, the markers of insulin resistance and the antioxidant status of the host without negative changes in the intestinal tract.	Polyphenols	93-104	insulin	Oryctolagus cuniculus	193-200
25516005-0	2014	Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.	Polyphenols	10-20	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
25516005-1	2014	INTRODUCTION: Epigallocatechin 3-gallate (EGCG), a polyphenol present in green tea, was shown to exert chondroprotective effects in vitro.	Polyphenols	51-61	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	79-82
25256691-8	2014	Polyphenols were removed in the search for specific enzyme inhibitors against hyaluronidase, phospholipase A2 or proteases from extracts with IC50 values below 100microg/ml.	Polyphenols	0-11	phospholipase A2 group IB	Homo sapiens	93-109
24582567-3	2014	Resveratrol is a polyphenol that prevents high-energy diet-induced steatosis and insulin resistance in animals by up-regulating pathways that regulate energy metabolism.	Polyphenols	17-27	insulin	Homo sapiens	81-88
25002134-1	2014	INTRODUCTION: Cecropia pachystachya (CP) is a plant rich in polyphenols which inhibits the angiotensin-converting enzyme (ACE) in vitro.	Polyphenols	60-71	angiotensin I converting enzyme	Rattus norvegicus	122-125
25365042-1	2014	The molecular interactions between pancreatic lipase (PL) and four tea polyphenols (EGCG analogs), like (-)-epigallocatechin gallate (EGCG), (-)-gallocatechin gallate (GCG), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin (EC), were studied from PL activity, conformation, kinetics and thermodynamics.	Polyphenols	71-82	pancreatic lipase	Homo sapiens	35-52
25272193-4	2014	A genome-wide association study (GWAS) with 404,628 SNP markers identified novel quantitative trait loci for sorghum polyphenols, some of which colocalized with homologues of flavonoid pathway genes from other plants, including an orthologue of maize (Zea mays) Pr1 and a homologue of Arabidopsis (Arabidopsis thaliana) TT16.	Polyphenols	117-128	pathogenesis related protein 4	Zea mays	262-265
25272193-4	2014	A genome-wide association study (GWAS) with 404,628 SNP markers identified novel quantitative trait loci for sorghum polyphenols, some of which colocalized with homologues of flavonoid pathway genes from other plants, including an orthologue of maize (Zea mays) Pr1 and a homologue of Arabidopsis (Arabidopsis thaliana) TT16.	Polyphenols	117-128	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	320-324
25079872-7	2014	Administration of EP pomace polyphenol extract significantly improved macroscopic and microscopic damage scores, as well as myeloperoxidase (MPO) activity in TNBS-treated mice.	Polyphenols	28-38	myeloperoxidase	Mus musculus	124-139
25214070-0	2014	Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells.	Polyphenols	7-17	androgen receptor	Homo sapiens	115-132
25352148-0	2014	Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation.	Polyphenols	10-20	Wnt family member 3A	Homo sapiens	37-40
25352148-0	2014	Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation.	Polyphenols	10-20	catenin beta 1	Homo sapiens	41-53
25352148-0	2014	Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation.	Polyphenols	10-20	glycogen synthase kinase 3 beta	Homo sapiens	77-86
25352148-0	2014	Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation.	Polyphenols	10-20	protein phosphatase 2 phosphatase activator	Homo sapiens	92-96
25352148-0	2014	Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation.	Polyphenols	10-20	catenin beta 1	Homo sapiens	109-121
25352148-1	2014	(-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, has been reported to inhibit the Wnt/beta-catenin pathway, which is aberrantly up-regulated in colorectal cancers, but its precise mechanism of action remains unclear.	Polyphenols	49-59	Wnt family member 3A	Homo sapiens	107-110
25352148-1	2014	(-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, has been reported to inhibit the Wnt/beta-catenin pathway, which is aberrantly up-regulated in colorectal cancers, but its precise mechanism of action remains unclear.	Polyphenols	49-59	catenin beta 1	Homo sapiens	111-123
25297556-8	2014	Additionally, treating beta-cell lines and human islets with these polyphenols led to increased intracellular cAMP levels in a manner similar to 3-isobutyl-1-methylxanthine, a classic PDE inhibitor.	Polyphenols	67-78	phosphodiesterase 10A	Homo sapiens	184-187
25297556-11	2014	Collectively, we demonstrate a novel role for natural-occurring polyphenols as PDE inhibitors that enhance pancreatic beta-cell function.	Polyphenols	64-75	phosphodiesterase 10A	Homo sapiens	79-82
25347454-0	2014	Compared binding properties between resveratrol and other polyphenols to plasmatic albumin: consequences for the health protecting effect of dietary plant microcomponents.	Polyphenols	58-69	albumin	Homo sapiens	83-90
25347454-8	2014	These results support a role played by polyphenols-albumin interactions in the plasma for the bio-activities of these food microcomponents in the body.	Polyphenols	39-50	albumin	Homo sapiens	51-58
24946050-7	2014	In this review, we describe various plant-derived polyphenols that can suppress TNF-alpha activated inflammatory pathways both in vitro and in vivo.	Polyphenols	50-61	tumor necrosis factor	Homo sapiens	80-89
25299185-0	2014	Red wine polyphenol compounds favor neovascularisation through estrogen receptor alpha-independent mechanism in mice.	Polyphenols	9-19	estrogen receptor 1 (alpha)	Mus musculus	63-86
26461284-9	2014	In addition, polyphenols may possibly also improve the endothelial function by preventing the induction of endothelial senescence to high glucose and angiotensin II.	Polyphenols	13-24	angiotensinogen	Homo sapiens	150-164
24946050-0	2014	Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols.	Polyphenols	80-91	tumor necrosis factor	Homo sapiens	18-39
24973642-0	2014	Protective effects of polyphenols-enriched extract from Huangshan Maofeng green tea against CCl4-induced liver injury in mice.	Polyphenols	22-33	chemokine (C-C motif) ligand 4	Mus musculus	92-96
24206194-2	2014	In the present study, we investigated the ability of green tea polyphenols to induce human beta-defensin (hBD) secretion in gingival epithelial cells and to protect hBDs from proteolytic degradation by Porphyromonas gingivalis.	Polyphenols	63-74	HBD	Homo sapiens	106-109
24206194-8	2014	Expression of the hBD gene in gingival epithelial cells treated with green tea polyphenols was also increased.	Polyphenols	79-90	HBD	Homo sapiens	18-21
25260046-3	2014	Several findings have suggested that polyphenols could influence cellular function by acting as activators of SIRT1, a nuclear histone deacetylase, involved in the inhibition of NF-kappaB signaling.	Polyphenols	37-48	sirtuin 1	Homo sapiens	110-115
25260075-12	2014	This work provides a basis of comparison to work on polyphenol based inhibitors of IAPP amyloid formation and helps provide clues as to the features which render them effective.	Polyphenols	52-62	islet amyloid polypeptide	Homo sapiens	83-87
30011737-4	2014	A significant decrease in polyphenols was observed for the sample collected from dialysis phase, with only 11% of non-digested original polyphenols permeating through the dialysis membrane (0.63mg) and preserving an inhibitory effect against alpha-glucosidase to some extent.	Polyphenols	26-37	sucrase-isomaltase	Homo sapiens	242-259
25272043-0	2014	The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-beta-induced myofibroblast phenotypes through RhoA and ERK inhibition.	Polyphenols	4-15	transforming growth factor beta 1	Homo sapiens	84-92
25272043-0	2014	The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-beta-induced myofibroblast phenotypes through RhoA and ERK inhibition.	Polyphenols	4-15	ras homolog family member A	Homo sapiens	134-138
25272043-0	2014	The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-beta-induced myofibroblast phenotypes through RhoA and ERK inhibition.	Polyphenols	4-15	mitogen-activated protein kinase 1	Homo sapiens	143-146
25272043-4	2014	Herein, we demonstrate that micromolar combinations of EGCG and a second polyphenol, luteolin, synergistically inhibit TGF-beta-induced myofibroblast phenotypes in prostate fibroblast cell lines, as observed primarily by potentiation of fibronectin expression.	Polyphenols	73-83	transforming growth factor beta 1	Homo sapiens	119-127
25264771-0	2014	Reorganisation of the salivary mucin network by dietary components: insights from green tea polyphenols.	Polyphenols	92-103	LOC100508689	Homo sapiens	31-36
26417309-8	2014	The polyphenols proved to have anti-inflammatory activity as evidenced by the suppression of inducible nitric oxide (iNO) and cytokine (TNF-alpha) levels in the culture supernatant of lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages.	Polyphenols	4-15	tumor necrosis factor	Mus musculus	136-145
24836925-0	2014	Wine polyphenols exert antineoplasic effect on androgen resistant PC-3 cell line through the inhibition of the transcriptional activity of COX-2 promoter mediated by NF-kbeta.	Polyphenols	5-16	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-144
24836925-3	2014	We intend to clarify whether resveratrol and other polyphenols effectively inhibit COX-2 activity and induce apoptosis in hormone-resistant PC-3 cell line.	Polyphenols	51-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-88
24836925-16	2014	CONCLUSIONS: Polyphenols inhibit transcriptional activity of COX-2 promoter mediated by NF-kbeta.	Polyphenols	13-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-66
25162539-2	2014	We show using a combination of particle tracking microrheology and small-angle neutron scattering that polyphenols acts as cross-linkers for purified gastrointestinal mucin, derived from the stomach and the duodenum.	Polyphenols	103-114	LOC100508689	Homo sapiens	167-172
25162539-5	2014	The viscosity, elasticity and relaxation time of the mucin solutions experience an order of magnitude change in value upon addition of the polyphenol cross-linkers.	Polyphenols	139-149	LOC100508689	Homo sapiens	53-58
24792245-4	2014	Thus, this study aimed to identify microRNAs (miRNAs) involved in the modulation of pro-angiogenic factors in the atherosclerotic plaques of LDL receptor gene knockout mice treated with a polyphenol-rich extract of Chilean propolis.	Polyphenols	188-198	low density lipoprotein receptor	Mus musculus	141-153
24792245-12	2014	In conclusion, our data analysis provides evidence that the anti-angiogenic effects of polyphenols from Chilean propolis can be modulated by miRNAs, in particular miR-181a, miR-106a and miR-20b.	Polyphenols	87-98	microRNA 181a-2	Mus musculus	163-171
24792245-12	2014	In conclusion, our data analysis provides evidence that the anti-angiogenic effects of polyphenols from Chilean propolis can be modulated by miRNAs, in particular miR-181a, miR-106a and miR-20b.	Polyphenols	87-98	microRNA 106a	Mus musculus	173-181
24792245-12	2014	In conclusion, our data analysis provides evidence that the anti-angiogenic effects of polyphenols from Chilean propolis can be modulated by miRNAs, in particular miR-181a, miR-106a and miR-20b.	Polyphenols	87-98	microRNA 20b	Mus musculus	186-193
25074384-0	2014	Inhibition of the intestinal sodium-coupled glucose transporter 1 (SGLT1) by extracts and polyphenols from apple reduces postprandial blood glucose levels in mice and humans.	Polyphenols	90-101	solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog	Xenopus laevis	67-72
25074384-2	2014	METHODS AND RESULTS: We here demonstrate that an extract and individual polyphenols from apple diminish sodium-coupled glucose transporter 1 (SGLT1) mediated glucose uptake in vitro and in vivo.	Polyphenols	72-83	solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog	Xenopus laevis	142-147
24726691-0	2014	Effects of resveratrol and other wine polyphenols on the proliferation, apoptosis and androgen receptor expression in LNCaP cells.	Polyphenols	38-49	androgen receptor	Homo sapiens	86-103
25046327-1	2014	The presence of antinutritional constituents in rapeseed protein products (RPI), such as polyphenols, phytates, allyl isothiocyanates, and glucosinolates, is a formidable constraint.	Polyphenols	89-100	ribose 5-phosphate isomerase A	Homo sapiens	75-78
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	caspase 3	Homo sapiens	144-153
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	caspase 8	Homo sapiens	155-164
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	caspase 9	Homo sapiens	166-175
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	Fas ligand	Homo sapiens	181-185
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	BCL2 associated X, apoptosis regulator	Homo sapiens	187-190
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	tumor protein p53	Homo sapiens	192-195
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	H3 histone pseudogene 16	Homo sapiens	197-200
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	E2F transcription factor 1	Homo sapiens	202-206
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	tumor protein p73	Homo sapiens	208-211
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	BCL2 apoptosis regulator	Homo sapiens	231-236
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	BCL2 like 1	Homo sapiens	238-244
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	baculoviral IAP repeat containing 3	Homo sapiens	246-252
25100434-5	2014	By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p &lt; 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions.	Polyphenols	46-56	baculoviral IAP repeat containing 2	Homo sapiens	258-264
24875446-0	2014	Assessment of the potential of polyphenols as a CYP17 inhibitor free of adverse corticosteroid elevation.	Polyphenols	31-42	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	48-53
24875446-3	2014	In this study, we evaluated the likelihood of polyphenols as a CYP17 inhibitor without cardiovascular complications.	Polyphenols	46-57	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	63-68
24875446-4	2014	All examined polyphenols significantly inhibited CYP17 in human adrenocortical H295R cells, but their effects on androgen and cortisol biosynthesis were diverse.	Polyphenols	13-24	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	49-54
24941909-5	2014	Some studies indicated that polyphenols may improve mitochondrial dysfunction, maintain the podocyte integrity and have therapeutic effects on glomerular diseases by promoting PGC-1alpha expression.	Polyphenols	28-39	PPARG coactivator 1 alpha	Rattus norvegicus	176-186
24835632-7	2014	Moreover, we demonstrated that certain potent inhibitors of alpha-syn fibrillation, such as oxidized catecholamines and polyphenols, undergo spontaneous oxidation in aqueous solution, generating compounds that strongly quench ThT fluorescence.	Polyphenols	120-131	synuclein alpha	Homo sapiens	60-69
25070040-0	2014	Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells.	Polyphenols	63-74	histone deacetylase 9	Homo sapiens	14-18
25070040-3	2014	These polyphenols modulate the activity of several proteins involved in cell growth and death in cancer cells, including histone deacetylases (HDAC), but the role of HDAC in senescence induced by Rsv and Quer is unclear.	Polyphenols	6-17	histone deacetylase 9	Homo sapiens	143-147
25070040-6	2014	Altogether, these data support a positive role of HDAC inhibition on the senescence induced by these polyphenols, and therefore co-treatment of HDAC inhibitors and polyphenols emerges as a potential alternative for gliomas.	Polyphenols	101-112	histone deacetylase 9	Homo sapiens	50-54
25070040-6	2014	Altogether, these data support a positive role of HDAC inhibition on the senescence induced by these polyphenols, and therefore co-treatment of HDAC inhibitors and polyphenols emerges as a potential alternative for gliomas.	Polyphenols	164-175	histone deacetylase 9	Homo sapiens	50-54
24911970-4	2014	In this study, we determined that resveratrol, a natural polyphenol, induced renal Klotho expression both in vivo and in vitro.	Polyphenols	57-67	Klotho	Rattus norvegicus	83-89
24839007-0	2014	Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells.	Polyphenols	46-56	BCL2 associated X, apoptosis regulator	Homo sapiens	8-11
24839007-0	2014	Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells.	Polyphenols	46-56	BCL2 apoptosis regulator	Homo sapiens	12-17
24839007-0	2014	Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells.	Polyphenols	46-56	tumor protein p53	Homo sapiens	80-83
24839007-1	2014	Green tea polyphenol (GTP) is one of the most promising chemopreventive agent for cancer; it can inhibit cancer cell proliferation and induce apoptosis through p53-dependent cell signaling pathways.	Polyphenols	10-20	tumor protein p53	Homo sapiens	160-163
24879560-1	2014	In the present study, we found that three enzymes, MVK, MDD and FPPS, in the mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols ((-)-epicatechin-3-gallate, ECG; (-)-epigallocatechin-3-gallate, EGCG).	Polyphenols	180-191	mevalonate kinase	Homo sapiens	51-54
24879560-1	2014	In the present study, we found that three enzymes, MVK, MDD and FPPS, in the mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols ((-)-epicatechin-3-gallate, ECG; (-)-epigallocatechin-3-gallate, EGCG).	Polyphenols	180-191	farnesyl diphosphate synthase	Homo sapiens	64-68
33412696-3	2014	To date, many applications related to the design and development of functional ice cream have been documented, including products containing probiotics, prebiotics, synbiotics, dietary fibers, natural antioxidants such as polyphenols, essential and polyunsaturated fatty acids, and low glycemic index blends and blends fortified with mineral or trace elements.	Polyphenols	222-233	carboxylesterase 2	Homo sapiens	79-82
24828476-6	2014	Furthermore, polyphenols may act synergistically due to their influence on efflux transporters such as p-glycoprotein.	Polyphenols	13-24	ATP binding cassette subfamily B member 1	Homo sapiens	103-117
24768660-1	2014	The aims of the present study were to investigate, in diabetes mellitus (DM), the mechanism of NOX4 up-regulation, its link with 5" adenosine monophosphate-activated protein kinase (AMPK) inactivation and transforming growth factor (TGF) ss-1 signaling in determining the accumulation of kidney extracellular matrix (ECM), and the possible action of cocoa enriched with polyphenols (CH) in these events.	Polyphenols	370-381	NADPH oxidase 4	Homo sapiens	95-99
24630969-8	2014	At the same time, tea polyphenol pretreatment attenuated the increased level of serum IL-1beta, IL-6, ICAM-1 and TNF-alpha, and enhanced IL-10 production in RIRI rats.	Polyphenols	22-32	interleukin 10	Rattus norvegicus	137-142
24630969-10	2014	These results cumulatively indicate that tea polyphenol pretreatment could suppress the TLR4/NF-kappaB p65 signaling pathway, protecting renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis, which implies that antioxidants may be a potential and effective agent for prevention of the ischemic/reperfusion injury through the suppression extrinsic apoptotic signal pathway induced by TLR4/NF-kappaB p65 signal pathway.	Polyphenols	45-55	toll-like receptor 4	Rattus norvegicus	88-92
24630969-10	2014	These results cumulatively indicate that tea polyphenol pretreatment could suppress the TLR4/NF-kappaB p65 signaling pathway, protecting renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis, which implies that antioxidants may be a potential and effective agent for prevention of the ischemic/reperfusion injury through the suppression extrinsic apoptotic signal pathway induced by TLR4/NF-kappaB p65 signal pathway.	Polyphenols	45-55	synaptotagmin 1	Rattus norvegicus	103-106
24630969-10	2014	These results cumulatively indicate that tea polyphenol pretreatment could suppress the TLR4/NF-kappaB p65 signaling pathway, protecting renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis, which implies that antioxidants may be a potential and effective agent for prevention of the ischemic/reperfusion injury through the suppression extrinsic apoptotic signal pathway induced by TLR4/NF-kappaB p65 signal pathway.	Polyphenols	45-55	toll-like receptor 4	Rattus norvegicus	407-411
24630969-10	2014	These results cumulatively indicate that tea polyphenol pretreatment could suppress the TLR4/NF-kappaB p65 signaling pathway, protecting renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis, which implies that antioxidants may be a potential and effective agent for prevention of the ischemic/reperfusion injury through the suppression extrinsic apoptotic signal pathway induced by TLR4/NF-kappaB p65 signal pathway.	Polyphenols	45-55	synaptotagmin 1	Rattus norvegicus	422-425
24577454-1	2014	Polyphenol extracts from coloured fruits and vegetables inhibit alpha-glucosidase in vitro, however it is not known whether this translates into an attenuation of blood glucose response in vivo.	Polyphenols	0-10	neutral alpha-glucosidase AB-like	Solanum tuberosum	64-81
24630969-0	2014	Protective effect of tea polyphenols on renal ischemia/reperfusion injury via suppressing the activation of TLR4/NF-kappaB p65 signal pathway.	Polyphenols	25-36	toll-like receptor 4	Rattus norvegicus	108-112
24630969-0	2014	Protective effect of tea polyphenols on renal ischemia/reperfusion injury via suppressing the activation of TLR4/NF-kappaB p65 signal pathway.	Polyphenols	25-36	synaptotagmin 1	Rattus norvegicus	123-126
24630969-7	2014	Moreover, tea polyphenol pretreatment significantly decreased TLR4 and NF-kappaB p65 protein expression levels in RIRI rats.	Polyphenols	14-24	toll-like receptor 4	Rattus norvegicus	62-66
24630969-7	2014	Moreover, tea polyphenol pretreatment significantly decreased TLR4 and NF-kappaB p65 protein expression levels in RIRI rats.	Polyphenols	14-24	synaptotagmin 1	Rattus norvegicus	81-84
24630969-8	2014	At the same time, tea polyphenol pretreatment attenuated the increased level of serum IL-1beta, IL-6, ICAM-1 and TNF-alpha, and enhanced IL-10 production in RIRI rats.	Polyphenols	22-32	interleukin 1 beta	Rattus norvegicus	86-94
24630969-8	2014	At the same time, tea polyphenol pretreatment attenuated the increased level of serum IL-1beta, IL-6, ICAM-1 and TNF-alpha, and enhanced IL-10 production in RIRI rats.	Polyphenols	22-32	interleukin 6	Rattus norvegicus	96-100
24630969-8	2014	At the same time, tea polyphenol pretreatment attenuated the increased level of serum IL-1beta, IL-6, ICAM-1 and TNF-alpha, and enhanced IL-10 production in RIRI rats.	Polyphenols	22-32	intercellular adhesion molecule 1	Rattus norvegicus	102-108
24630969-8	2014	At the same time, tea polyphenol pretreatment attenuated the increased level of serum IL-1beta, IL-6, ICAM-1 and TNF-alpha, and enhanced IL-10 production in RIRI rats.	Polyphenols	22-32	tumor necrosis factor	Rattus norvegicus	113-122
24886552-1	2014	BACKGROUND: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance.	Polyphenols	12-23	insulin	Homo sapiens	227-234
24334237-0	2014	Regulating effect of tea polyphenols on endothelin, intracellular calcium concentration, and mitochondrial membrane potential in vascular endothelial cells injured by Angiotensin II.	Polyphenols	25-36	angiotensinogen	Homo sapiens	167-181
24334237-3	2014	The objective of this study was to study the regulating effects of tea polyphenols on these factors in VECs injured by angiotensin II (Ang-II) and explore the protective effect of tea polyphenols on human VECs.	Polyphenols	71-82	angiotensinogen	Homo sapiens	119-133
24334237-3	2014	The objective of this study was to study the regulating effects of tea polyphenols on these factors in VECs injured by angiotensin II (Ang-II) and explore the protective effect of tea polyphenols on human VECs.	Polyphenols	71-82	angiotensinogen	Homo sapiens	135-141
24334237-6	2014	RESULTS: The results showed the following: (1) tea polyphenols decreased the expression of endothelin-1 messenger RNA, which was increased by Ang-II (P &lt; 0.01).	Polyphenols	51-62	endothelin 1	Homo sapiens	91-103
24334237-6	2014	RESULTS: The results showed the following: (1) tea polyphenols decreased the expression of endothelin-1 messenger RNA, which was increased by Ang-II (P &lt; 0.01).	Polyphenols	51-62	angiotensinogen	Homo sapiens	142-148
24334237-7	2014	(2) Tea polyphenols inhibited endothelin secretion induced by Ang-II (P &lt; 0.01), and the inhibition of low-concentration tea polyphenols was superior to that of high concentration tea polyphenols (P &lt; 0.01).	Polyphenols	8-19	angiotensinogen	Homo sapiens	62-68
24334237-8	2014	(3) Tea polyphenols ameliorated the changes in intracellular calcium concentration and mitochondrial membrane potential induced by Ang-II (P &lt; 0.01).	Polyphenols	8-19	angiotensinogen	Homo sapiens	131-137
24577454-11	2014	In vitro, polyphenol extracts of red and purple potatoes inhibited alpha-glucosidase by 37.4 +- 2.2% and 28.7 +- 3.2%, respectively.	Polyphenols	10-20	neutral alpha-glucosidase AB-like	Solanum tuberosum	67-84
24577454-12	2014	The GI of coloured potatoes is significantly related to their polyphenol content, possibly mediated through an inhibitory effect of anthocyanins on intestinal alpha-glucosidase.	Polyphenols	62-72	neutral alpha-glucosidase AB-like	Solanum tuberosum	159-176
24631135-0	2014	Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100beta secretion by regulating sirtuin 1 in C6 rat glioma cells.	Polyphenols	9-20	S100 calcium binding protein B	Rattus norvegicus	80-88
24407905-0	2014	The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity.	Polyphenols	4-14	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	38-43
24407905-0	2014	The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity.	Polyphenols	4-14	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	151-158
24407905-0	2014	The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity.	Polyphenols	4-14	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	160-166
25191617-7	2014	Betalains, polyphenols and dietary nitrate found in the beetroot juice may each contribute to the observed differences in the postprandial insulin concentration.	Polyphenols	11-22	insulin	Homo sapiens	139-146
24484937-2	2014	We have previously reported that the chemopreventive polyphenol Curcumin inhibits the expression of the proinflammatory cytokines CXCL1 and -2 leading to diminished formation of breast and prostate cancer metastases.	Polyphenols	53-63	C-X-C motif chemokine ligand 1	Homo sapiens	130-142
24631135-0	2014	Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100beta secretion by regulating sirtuin 1 in C6 rat glioma cells.	Polyphenols	9-20	sirtuin 1	Rattus norvegicus	113-122
24631135-4	2014	KEY FINDINGS: Cinnamon polyphenols (CP) counteracted the oxidative effects of H2O2 on S100beta secretion and expression.	Polyphenols	23-34	S100 calcium binding protein B	Rattus norvegicus	86-94
24393006-9	2014	Polyphenols also exerted an anti-inflammatory effect on preadipocytes exposed to H2O2 by reducing IL-6 secretion.	Polyphenols	0-11	interleukin 6	Mus musculus	98-102
24799987-3	2014	An interesting candidate is the natural polyphenol resveratrol (RSV) that activates adenosinmonophosphate-activated protein kinase (AMPK) and silent information regulation-2 homolog 1 (SIRT1).	Polyphenols	40-50	sirtuin 1	Homo sapiens	142-183
24799987-3	2014	An interesting candidate is the natural polyphenol resveratrol (RSV) that activates adenosinmonophosphate-activated protein kinase (AMPK) and silent information regulation-2 homolog 1 (SIRT1).	Polyphenols	40-50	sirtuin 1	Homo sapiens	185-190
23955640-10	2014	Addition of the polyphenol EGCG has a reverse effect on mucin viscoelasticity, that is, it triggers a sol-gel transition in semi-dilute mucin solutions at neutral pH.	Polyphenols	16-26	LOC100508689	Homo sapiens	56-61
23955640-10	2014	Addition of the polyphenol EGCG has a reverse effect on mucin viscoelasticity, that is, it triggers a sol-gel transition in semi-dilute mucin solutions at neutral pH.	Polyphenols	16-26	LOC100508689	Homo sapiens	136-141
24005799-8	2014	RESULTS: Histopathological analysis showed that animals treated with the polyphenol for 9 consecutive days displayed reduction on astrocyte activity on the corpus callosum and external capsule, shown by GFAP immunostaining.	Polyphenols	73-83	glial fibrillary acidic protein	Rattus norvegicus	203-207
24246683-3	2014	Hydroxytyrosol is an orally bioavailable polyphenol, obtained from olives, which inhibits NF-kappabeta activity and has elicited promising efficacy signals in several inflammatory diseases.	Polyphenols	41-51	nuclear factor kappa B subunit 1	Homo sapiens	90-102
24338263-5	2014	LOE contained high levels of polyphenols and flavonoids, which possess strong DPPH radical scavenging activity, and was shown to attenuate paraquat-induced oxidative damage and lethality in flies.	Polyphenols	29-40	SNF4/AMP-activated protein kinase gamma subunit	Drosophila melanogaster	0-3
24655494-7	2014	These findings demonstrate that polyphenol-rich CME may prevent hyperlipidemic fatty liver in mice, and its mechanisms may be related to the modulation of sterol regulatory element binding protein-1c, FAS, lipoprotein lipase, and cholesterol 7alpha-hydroxylase 1 expression through the PPARalpha-mediated pathway.	Polyphenols	32-42	lipoprotein lipase	Mus musculus	206-224
24444877-0	2014	Polyphenol compounds belonging to flavonoids inhibit activity of coagulation factor X.	Polyphenols	0-10	coagulation factor X	Homo sapiens	65-85
24444877-6	2014	We observed that only four polyphenols belonging to flavonoids group: procyanidin B2, cyanidin, quercetin and silybin, had inhibitory effect on FXa activity.	Polyphenols	27-38	coagulation factor X	Homo sapiens	144-147
24395567-3	2014	Our experiments led to the identification of sirtuin 1 (SIRT1) as a potential target in T-H. Administration of resveratrol (a naturally occurring polyphenol and activator of SIRT1) after T-H improved left ventricular function and tissue ATP levels.	Polyphenols	146-156	sirtuin 1	Rattus norvegicus	45-54
24395567-3	2014	Our experiments led to the identification of sirtuin 1 (SIRT1) as a potential target in T-H. Administration of resveratrol (a naturally occurring polyphenol and activator of SIRT1) after T-H improved left ventricular function and tissue ATP levels.	Polyphenols	146-156	sirtuin 1	Rattus norvegicus	56-61
24370660-4	2014	Five tea polyphenols exhibited inhibitory activity against influenza A virus in the trend of theaflavin&gt;procyanidin B-2&gt;procyanidin B-2 digallate&gt;(-)-epigallocatechin(EGC)&gt;(-)-epigallocatechingallate(EGCG) with IC50 values in the range of 16.2-56.5 mug/ml.	Polyphenols	9-20	immunoglobulin kappa variable 5-2	Homo sapiens	119-122
24370660-4	2014	Five tea polyphenols exhibited inhibitory activity against influenza A virus in the trend of theaflavin&gt;procyanidin B-2&gt;procyanidin B-2 digallate&gt;(-)-epigallocatechin(EGC)&gt;(-)-epigallocatechingallate(EGCG) with IC50 values in the range of 16.2-56.5 mug/ml.	Polyphenols	9-20	immunoglobulin kappa variable 5-2	Homo sapiens	138-141
24059314-7	2014	Some drug agonists of AMPK are known to mimic these effects such as metformin or resveratrol, a polyphenol extracted from plants and present in red wine, a component of the French paradox related diet.	Polyphenols	96-106	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	22-26
25337568-0	2014	Polyphenols Isolated from Allium cepa L. Induces Apoptosis by Induction of p53 and Suppression of Bcl-2 through Inhibiting PI3K/Akt Signaling Pathway in AGS Human Cancer Cells.	Polyphenols	0-11	tumor protein p53	Homo sapiens	75-78
25337568-0	2014	Polyphenols Isolated from Allium cepa L. Induces Apoptosis by Induction of p53 and Suppression of Bcl-2 through Inhibiting PI3K/Akt Signaling Pathway in AGS Human Cancer Cells.	Polyphenols	0-11	BCL2 apoptosis regulator	Homo sapiens	98-103
25337568-0	2014	Polyphenols Isolated from Allium cepa L. Induces Apoptosis by Induction of p53 and Suppression of Bcl-2 through Inhibiting PI3K/Akt Signaling Pathway in AGS Human Cancer Cells.	Polyphenols	0-11	AKT serine/threonine kinase 1	Homo sapiens	128-131
24655494-7	2014	These findings demonstrate that polyphenol-rich CME may prevent hyperlipidemic fatty liver in mice, and its mechanisms may be related to the modulation of sterol regulatory element binding protein-1c, FAS, lipoprotein lipase, and cholesterol 7alpha-hydroxylase 1 expression through the PPARalpha-mediated pathway.	Polyphenols	32-42	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	230-260
24655494-7	2014	These findings demonstrate that polyphenol-rich CME may prevent hyperlipidemic fatty liver in mice, and its mechanisms may be related to the modulation of sterol regulatory element binding protein-1c, FAS, lipoprotein lipase, and cholesterol 7alpha-hydroxylase 1 expression through the PPARalpha-mediated pathway.	Polyphenols	32-42	peroxisome proliferator activated receptor alpha	Mus musculus	286-295
24558444-5	2014	Our results showed that administration of low dose reconstituted polyphenol OBs inhibited LPS-mediated inflammatory cytokine secretion, including IL-6, IL-23, and IL-12, while increasing IL-10 and IL-1Ralpha production.	Polyphenols	65-75	interleukin 6	Mus musculus	146-150
24558444-5	2014	Our results showed that administration of low dose reconstituted polyphenol OBs inhibited LPS-mediated inflammatory cytokine secretion, including IL-6, IL-23, and IL-12, while increasing IL-10 and IL-1Ralpha production.	Polyphenols	65-75	interleukin 23, alpha subunit p19	Mus musculus	152-157
24558444-5	2014	Our results showed that administration of low dose reconstituted polyphenol OBs inhibited LPS-mediated inflammatory cytokine secretion, including IL-6, IL-23, and IL-12, while increasing IL-10 and IL-1Ralpha production.	Polyphenols	65-75	interleukin 10	Mus musculus	187-192
24558444-5	2014	Our results showed that administration of low dose reconstituted polyphenol OBs inhibited LPS-mediated inflammatory cytokine secretion, including IL-6, IL-23, and IL-12, while increasing IL-10 and IL-1Ralpha production.	Polyphenols	65-75	interleukin 1 receptor antagonist	Mus musculus	197-207
24514562-4	2014	A correlation was observed between the polyphenol content and the MPO inhibition.	Polyphenols	39-49	myeloperoxidase	Homo sapiens	66-69
24551237-0	2014	Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes.	Polyphenols	23-34	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	71-75
24440697-5	2014	Our results indicate that polyphenols bind to monomeric tropoelastin and enhance coacervation, aid in crosslinking of elastin by increasing lysyl oxidase (LOX) synthesis, and by blocking MMP-2 activity.	Polyphenols	26-37	elastin	Rattus norvegicus	56-68
24440697-5	2014	Our results indicate that polyphenols bind to monomeric tropoelastin and enhance coacervation, aid in crosslinking of elastin by increasing lysyl oxidase (LOX) synthesis, and by blocking MMP-2 activity.	Polyphenols	26-37	elastin	Rattus norvegicus	61-68
24440697-5	2014	Our results indicate that polyphenols bind to monomeric tropoelastin and enhance coacervation, aid in crosslinking of elastin by increasing lysyl oxidase (LOX) synthesis, and by blocking MMP-2 activity.	Polyphenols	26-37	matrix metallopeptidase 2	Rattus norvegicus	187-192
24440697-6	2014	Thus, polyphenol treatments leads to increased mature elastin fibers synthesis without increasing the production of intracellular tropoelastin.	Polyphenols	6-16	elastin	Rattus norvegicus	54-61
24129950-4	2014	The purpose of this review is to evaluate recent progress in investigations of sage in vitro systems as tools for producing important terpenoids and polyphenols and in development of methods for manipulating regulatory processes to enhance secondary metabolite production in such systems.	Polyphenols	149-160	sarcoma antigen 1	Homo sapiens	79-83
24262216-8	2014	In addition, the links between natural products (e.g. polyphenols) and their associated modules and TFs are helpful to elucidate their polypharmacological effects in terms of activating specific TFs, such as ERs, nuclear factor-like 2 and peroxisome proliferator-activated receptor gamma.	Polyphenols	54-65	peroxisome proliferator activated receptor gamma	Homo sapiens	213-287
24502633-1	2014	This study was undertaken to determine the effectiveness of apple (Ralls) polyphenol extract (APE) in modulating aluminum chloride (AlCl3) induced hepatotoxicity in rats.	Polyphenols	74-84	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	94-97
24129950-2	2014	The economic importance of this genus has increased in recent years due to evidence that some of its secondary metabolites have valuable pharmaceutical and nutraceutical properties.The bioactivity of sage extracts is mainly due to their content of terpenes and polyphenols.	Polyphenols	261-272	sarcoma antigen 1	Homo sapiens	200-204
24633463-3	2014	Resveratrol, a polyphenol, has regulatory effects on hepatic lipid metabolism as a potent AMPK activator.	Polyphenols	15-25	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	90-94
24251781-7	2014	This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials, AMPK activation, PI3K/AkT inhibition, IKK/JNK inhibition, mTORC1 inhibition, JAK/STAT inhibition, TLR suppression, and ACE inhibition.	Polyphenols	44-55	AKT serine/threonine kinase 1	Homo sapiens	188-191
24251781-7	2014	This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials, AMPK activation, PI3K/AkT inhibition, IKK/JNK inhibition, mTORC1 inhibition, JAK/STAT inhibition, TLR suppression, and ACE inhibition.	Polyphenols	44-55	mitogen-activated protein kinase 8	Homo sapiens	208-211
24251781-7	2014	This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials, AMPK activation, PI3K/AkT inhibition, IKK/JNK inhibition, mTORC1 inhibition, JAK/STAT inhibition, TLR suppression, and ACE inhibition.	Polyphenols	44-55	CREB regulated transcription coactivator 1	Mus musculus	224-230
24251781-7	2014	This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials, AMPK activation, PI3K/AkT inhibition, IKK/JNK inhibition, mTORC1 inhibition, JAK/STAT inhibition, TLR suppression, and ACE inhibition.	Polyphenols	44-55	angiotensin I converting enzyme	Homo sapiens	285-288
24251781-8	2014	As a result, polyphenols readily lead to NFkappaB, AP-1, HIF, and STAT inactivations with reduced proinflammatory mediator generation.	Polyphenols	13-24	nuclear factor kappa B subunit 1	Homo sapiens	41-49
24251781-8	2014	As a result, polyphenols readily lead to NFkappaB, AP-1, HIF, and STAT inactivations with reduced proinflammatory mediator generation.	Polyphenols	13-24	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	51-55
24239092-4	2014	RESULTS: Cinnamon polyphenols significantly enhanced secretion of S100beta, a Ca(2+)-binding protein, and increased intracellular S100beta expression after 24 h of incubation, in rat C6 glioma cells.	Polyphenols	18-29	S100 calcium binding protein B	Rattus norvegicus	66-74
24239092-4	2014	RESULTS: Cinnamon polyphenols significantly enhanced secretion of S100beta, a Ca(2+)-binding protein, and increased intracellular S100beta expression after 24 h of incubation, in rat C6 glioma cells.	Polyphenols	18-29	S100 calcium binding protein B	Rattus norvegicus	130-138
24205990-5	2014	Polyphenols also target various additional platelet activation pathways (e.g. by blocking platelet-ADP, collagen receptors); thus alleviating fibrinogen binding to platelet surface (GPIIb-IIIa) receptors, reducing further platelet recruitment for aggregation and inhibiting platelet degranulation.	Polyphenols	0-11	fibrinogen beta chain	Homo sapiens	142-152
23676554-2	2014	The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD.	Polyphenols	10-20	DNA methyltransferase 1	Homo sapiens	94-117
25105137-5	2014	In the present study, it was investigated whether neurite outgrowth defects could be rescued by curcumin and resveratrol, which are SMN-inducing polyphenols, having HDAC inhibition activity.	Polyphenols	145-156	survival of motor neuron 1, telomeric	Rattus norvegicus	132-135
25035986-0	2014	A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.	Polyphenols	92-102	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	65-69
23676554-2	2014	The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD.	Polyphenols	10-20	DNA methyltransferase 1	Homo sapiens	119-124
23676554-2	2014	The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD.	Polyphenols	10-20	signal transducer and activator of transcription 1	Homo sapiens	130-180
23676554-2	2014	The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD.	Polyphenols	10-20	signal transducer and activator of transcription 1	Homo sapiens	182-187
23886380-7	2014	Red wine polyphenols improved swallowing reflex by enhancing TRPV1 response.	Polyphenols	9-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
23701564-6	2014	Intake of representative polyphenols (flavones, flavone-3-ols, catechins, anthocyanidins, flavanones, procyanidins, and resveratrol) can improve a skewed Th1/Th2 balance and suppress antigen-specific IgE antibody formation.	Polyphenols	25-36	negative elongation factor complex member C/D	Homo sapiens	154-157
23001493-0	2014	Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice.	Polyphenols	37-48	lipoprotein lipase	Mus musculus	78-96
24001852-2	2014	Blueberry polyphenol-rich extract was delivered to TIM-1 in the absence or presence of a high-fat meal.	Polyphenols	10-20	Rho guanine nucleotide exchange factor 5	Homo sapiens	51-56
24309288-5	2014	Resveratrol, a natural occurring polyphenol compound, was found to strongly protect RPE cells from sodium iodate with inhibition of production of ROS and IL-8.	Polyphenols	33-43	ribulose-5-phosphate-3-epimerase	Homo sapiens	84-87
24426047-4	2014	DIC sample showed a rise in redness, over 2.5 times greater than the control after spreading naturally for 24 h. Chemical determination revealed a better infusion behavior of tea polyphenols and amino acids in green tea manufactured by DIC method both at high and low temperature.	Polyphenols	179-190	solute carrier family 25 member 10	Homo sapiens	0-3
24171419-3	2014	For the UV light photo-Fenton degradation of oolong tea effluent being 70 mg-(polyphenol) L(-1), the optimum dosages of Fenton reagents were found to be 20 mgL(-1) of total Fe and 500 mgL(-1) of H2O2.	Polyphenols	78-88	LLGL scribble cell polarity complex component 1	Homo sapiens	156-162
25024312-4	2014	Resveratrol is a polyphenol that induces expression and activation of several neuroprotective pathways involving Sirtuin1 and AMPK.	Polyphenols	17-27	sirtuin 1	Mus musculus	113-121
24426047-4	2014	DIC sample showed a rise in redness, over 2.5 times greater than the control after spreading naturally for 24 h. Chemical determination revealed a better infusion behavior of tea polyphenols and amino acids in green tea manufactured by DIC method both at high and low temperature.	Polyphenols	179-190	solute carrier family 25 member 10	Homo sapiens	236-239
25436473-10	2014	Present results decisively suggest for the first time that CS and its mixed polyphenols have potent SOD1 protecting, diverse radical-scavenging and antimutagenic activities furthering to DNA protection/therapy in arsenic-induced tissue necrosis/apoptosis.	Polyphenols	76-87	superoxide dismutase 1	Rattus norvegicus	100-104
24426047-5	2014	The increase in tea polyphenols content in liquor for the first brew from twisted and needle tea was about 35% and that from flat tea was about 15% in DIC method over the traditional processing.	Polyphenols	20-31	solute carrier family 25 member 10	Homo sapiens	151-154
24817795-5	2014	We show that the natural polyphenol compound resveratrol (RSV) efficiently suppresses the expression of TNFalpha and IL-6 in an ATGL/PPARalpha dependent manner.	Polyphenols	25-35	tumor necrosis factor	Mus musculus	104-112
24176923-9	2014	The results are in accordance with previous stopped-flow kinetic studies which showed a high reactivity of the polyphenol with MPO compound II.	Polyphenols	111-121	myeloperoxidase	Homo sapiens	127-130
24610996-4	2014	The aim of our present study was to examine the effects of the well-known polyphenolic compounds on the activity of thrombin, by characterization of its interaction with selected polyphenols using different biochemical methods and biosensor BIAcore analyses.	Polyphenols	179-190	coagulation factor II, thrombin	Homo sapiens	116-124
24610996-5	2014	Only six compounds, cyanidin, quercetin, silybin, cyanin, (+)-catechin and (-)-epicatechin, of all examined in this study polyphenols caused the inhibition of thrombin amidolytic activity.	Polyphenols	122-133	coagulation factor II, thrombin	Homo sapiens	159-167
24817795-5	2014	We show that the natural polyphenol compound resveratrol (RSV) efficiently suppresses the expression of TNFalpha and IL-6 in an ATGL/PPARalpha dependent manner.	Polyphenols	25-35	interleukin 6	Mus musculus	117-121
24817795-5	2014	We show that the natural polyphenol compound resveratrol (RSV) efficiently suppresses the expression of TNFalpha and IL-6 in an ATGL/PPARalpha dependent manner.	Polyphenols	25-35	patatin-like phospholipase domain containing 2	Mus musculus	128-132
24817795-5	2014	We show that the natural polyphenol compound resveratrol (RSV) efficiently suppresses the expression of TNFalpha and IL-6 in an ATGL/PPARalpha dependent manner.	Polyphenols	25-35	peroxisome proliferator activated receptor alpha	Mus musculus	133-142
24343902-3	2014	In the present study, to examine the involvement of AP-1 in green tea polyphenols induced tumor inhibition, human NSCLC cell line H1299 and mouse SPON 10 cells were identified as AP-1 dependent, as these two lines exhibit high constitutive AP-1 activity, and when TAM67 expression was induced with doxycycline, cell growth was inhibited and correlated with suppressed AP-1 activity.	Polyphenols	70-81	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	66-69
24314860-5	2014	Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor gamma, CCAAT/enhancer binding protein alpha, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-kappaB that regulate adipogenesis, antioxidant and anti-inflammatory responses.	Polyphenols	19-30	sirtuin 1	Homo sapiens	279-288
24314860-5	2014	Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor gamma, CCAAT/enhancer binding protein alpha, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-kappaB that regulate adipogenesis, antioxidant and anti-inflammatory responses.	Polyphenols	19-30	uncoupling protein 1	Homo sapiens	290-363
22833520-9	2014	Furthermore, exposure of LNCaP cells to green tea polyphenols caused reexpression of GSTP1, which protected the cells from H2 O2 -mediated DNA damage through decreased ROS production compared to nonexposed cells.	Polyphenols	50-61	glutathione S-transferase pi 1	Homo sapiens	85-90
24343902-4	2014	RNA-seq was used to determine the global transcriptional effects of AP-1 inhibition and also uncover the possible involvement of AP-1 in tea polyphenols induced chemoprevention.	Polyphenols	141-152	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-133
24413998-3	2014	Resveratrol (Resv), a natural polyphenol, has been identified as a potent activator of forkhead transcription factor O1 (FoxO1) which can up-regulate the expression of AdipoR1.	Polyphenols	30-40	forkhead box O1	Rattus norvegicus	121-126
24343902-4	2014	RNA-seq was used to determine the global transcriptional effects of AP-1 inhibition and also uncover the possible involvement of AP-1 in tea polyphenols induced chemoprevention.	Polyphenols	141-152	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	137-140
24413998-3	2014	Resveratrol (Resv), a natural polyphenol, has been identified as a potent activator of forkhead transcription factor O1 (FoxO1) which can up-regulate the expression of AdipoR1.	Polyphenols	30-40	adiponectin receptor 1	Rattus norvegicus	168-175
24865115-2	2014	daily administration for 15 consecutive days of a blend of polyphenols, containing mostly oleuropein, extracted from the olive leaves (Olea europaea) on brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and on the expression of their receptors, TrkA, TrkB and p75.	Polyphenols	59-70	nerve growth factor	Mus musculus	180-183
24865115-6	2014	In conclusion, olive polyphenols may not only elicit an activation of the rodent olfactory system by increasing the levels of NGF and BDNF but also be stressing for the animal by reducing both the levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF and BDNF.	Polyphenols	21-32	nerve growth factor	Mus musculus	126-129
23881751-0	2014	Epigenetic effects of natural polyphenols: a focus on SIRT1-mediated mechanisms.	Polyphenols	30-41	sirtuin 1	Homo sapiens	54-59
24122080-9	2014	The atomic structure of the ECG-GDH complex and mutagenesis studies is directing structure-based drug design using these polyphenols as a base scaffold.	Polyphenols	121-132	glutamate dehydrogenase 1	Homo sapiens	32-35
25256427-4	2014	Concentration of 50 mug/ml (50 mug total monomeric polyphenols/ml) AF4 was sufficient to induce a significant reduction in cell viability within 6 h of treatment (92%, P &lt; 0.05) but had very low toxicity (minimum 4% to maximum 16%) on primary liver and lung cells, which was significantly lower than currently prescribed chemotherapy drug Sorafenib (minimum 29% to maximum 49%, P &lt; 0.05).	Polyphenols	51-62	AF4/FMR2 family member 1	Homo sapiens	67-70
24865115-6	2014	In conclusion, olive polyphenols may not only elicit an activation of the rodent olfactory system by increasing the levels of NGF and BDNF but also be stressing for the animal by reducing both the levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF and BDNF.	Polyphenols	21-32	brain derived neurotrophic factor	Mus musculus	134-138
24865115-6	2014	In conclusion, olive polyphenols may not only elicit an activation of the rodent olfactory system by increasing the levels of NGF and BDNF but also be stressing for the animal by reducing both the levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF and BDNF.	Polyphenols	21-32	nerve growth factor	Mus musculus	219-222
24865115-6	2014	In conclusion, olive polyphenols may not only elicit an activation of the rodent olfactory system by increasing the levels of NGF and BDNF but also be stressing for the animal by reducing both the levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF and BDNF.	Polyphenols	21-32	brain derived neurotrophic factor	Mus musculus	223-227
24865115-6	2014	In conclusion, olive polyphenols may not only elicit an activation of the rodent olfactory system by increasing the levels of NGF and BDNF but also be stressing for the animal by reducing both the levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF and BDNF.	Polyphenols	21-32	nerve growth factor	Mus musculus	219-222
24865115-6	2014	In conclusion, olive polyphenols may not only elicit an activation of the rodent olfactory system by increasing the levels of NGF and BDNF but also be stressing for the animal by reducing both the levels of hippocampal NGF/BDNF and serum GSH and increasing serum levels of NGF and BDNF.	Polyphenols	21-32	brain derived neurotrophic factor	Mus musculus	223-227
24865115-2	2014	daily administration for 15 consecutive days of a blend of polyphenols, containing mostly oleuropein, extracted from the olive leaves (Olea europaea) on brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and on the expression of their receptors, TrkA, TrkB and p75.	Polyphenols	59-70	brain derived neurotrophic factor	Mus musculus	224-228
24865115-3	2014	Polyphenols decreased the levels of reduced glutathione (GSH) and increased the levels of NGF and BDNF in the serum.	Polyphenols	0-11	nerve growth factor	Mus musculus	90-93
24865115-3	2014	Polyphenols decreased the levels of reduced glutathione (GSH) and increased the levels of NGF and BDNF in the serum.	Polyphenols	0-11	brain derived neurotrophic factor	Mus musculus	98-102
25295218-0	2014	In Vitro Studies on the Antioxidant Property and Inhibition of alpha-Amylase, alpha-Glucosidase, and Angiotensin I-Converting Enzyme by Polyphenol-Rich Extracts from Cocoa (Theobroma cacao) Bean.	Polyphenols	136-146	alpha-amylase	Theobroma cacao	63-76
25050143-8	2014	However, the results of clinical observations suggest that the favorable hypotensive action of chokeberry polyphenols may be an outcome of both ACE inhibition and other pleotropic effects, for example, antioxidative effect.	Polyphenols	106-117	angiotensin I converting enzyme	Homo sapiens	144-147
24148349-4	2013	The most abundant green tea polyphenol, epigallocatechin-3-gallate (EGCG), has been shown to have vasodilator action in vessels by activation of endothelial nitric oxide synthase (eNOS).	Polyphenols	28-38	nitric oxide synthase 3, endothelial cell	Mus musculus	145-178
24421757-4	2013	Besides these well-documented properties, the modulatory action of these polyphenols on intracellular signaling pathways related to cell death/survival (e.g., protein kinase C, PKC) has yet to be investigated in detail.	Polyphenols	73-84	protein kinase C, gamma	Rattus norvegicus	177-180
24421757-7	2013	Moreover, immunofluorescence data revealed that cells treated with these polyphenols increased PKC gamma (gamma) activation and promoted neuronal interconnections.	Polyphenols	73-84	protein kinase C, gamma	Rattus norvegicus	95-104
24421757-8	2013	Finally, we found that the protective effects of both polyphenols on the cytoskeleton and synaptic plasticity were mediated by the PKCgamma subunit.	Polyphenols	54-65	protein kinase C, gamma	Rattus norvegicus	131-139
24908086-10	2014	Potential therapeutic targets on the molecular level (oxidative stress markers, gene for DYRK1A, neutrophic factor BDNF) after intervention of natural polyphenols are also discussed.	Polyphenols	151-162	brain derived neurotrophic factor	Homo sapiens	115-119
25460732-9	2014	Moreover, we observed that high glucose and free fatty acids reduced NO and increased ET-1 levels induced by acetylcholine through the modulation of intracellular calcium concentrations and endothelial NO synthase phosphorylation, events also reverted by hydroxytyrosol and polyphenol extract.	Polyphenols	274-284	endothelin 1	Homo sapiens	86-90
25174366-8	2014	In a survey of natural ligands that bind to the aryl hydrocarbon receptor (AhR), nepitrin, a flavonoid glycoside, and other polyphenols were revealed to be promising therapeutic candidates.	Polyphenols	124-135	aryl hydrocarbon receptor	Homo sapiens	48-73
25174366-8	2014	In a survey of natural ligands that bind to the aryl hydrocarbon receptor (AhR), nepitrin, a flavonoid glycoside, and other polyphenols were revealed to be promising therapeutic candidates.	Polyphenols	124-135	aryl hydrocarbon receptor	Homo sapiens	75-78
23993534-6	2013	Unlike dried cranberry pomace extract alone, proanthocyanidins, anthocyanins and total polyphenols were found to be highly stable at 37  C in the CBP-SPI powder.	Polyphenols	87-98	chromogranin A	Homo sapiens	150-153
23993534-7	2013	The extraction and stabilization of cranberry pomace polyphenols using SPI provides an innovative approach for utilizing pomace in the development of novel food ingredients.	Polyphenols	53-64	chromogranin A	Homo sapiens	71-74
23993587-0	2013	Modulation of interferon-gamma synthesis by the effects of lignin-like enzymatically polymerized polyphenols on antigen-presenting cell activation and the subsequent cell-to-cell interactions.	Polyphenols	97-108	interferon gamma	Homo sapiens	14-30
23993587-7	2013	Additionally, adequate interferon-gamma (IFN-gamma) induction by polymerized polyphenols was mediated by the coexistence of APCs and T cells because the addition of T cells to PCCs increased IFN-gamma production.	Polyphenols	77-88	interferon gamma	Homo sapiens	23-39
23993587-7	2013	Additionally, adequate interferon-gamma (IFN-gamma) induction by polymerized polyphenols was mediated by the coexistence of APCs and T cells because the addition of T cells to PCCs increased IFN-gamma production.	Polyphenols	77-88	interferon gamma	Homo sapiens	41-50
23993587-7	2013	Additionally, adequate interferon-gamma (IFN-gamma) induction by polymerized polyphenols was mediated by the coexistence of APCs and T cells because the addition of T cells to PCCs increased IFN-gamma production.	Polyphenols	77-88	interferon gamma	Homo sapiens	191-200
23996120-3	2013	The molecular weights of the produced polyphenols were determined with GPC.	Polyphenols	38-49	glycophorin C (Gerbich blood group)	Homo sapiens	71-74
23796248-6	2013	RESULTS: Emodin, quercetin, and cis-stilbene were the most effective polyphenols at decreasing cell viability (IC50 values of 5-22 muM, 8-33 muM, and 25-85 muM respectively) and inducing apoptosis (AP50 values (the concentration which 50% of cells undergo apoptosis) of 2-27 muM, 19-50 muM, and 8-50 muM respectively).	Polyphenols	69-80	adaptor related protein complex 2 subunit mu 1	Homo sapiens	198-202
24158698-6	2013	In this paper, Multivariate analysis of the LC-MS data of tea extracts and binding assays showed that the tea polyphenol EGCG can form stable complex with iron through the protein Ngal, a biomarker of acute kidney injury.	Polyphenols	110-120	lipocalin 2	Homo sapiens	180-184
23990052-0	2013	Epigallocatechin-3-O-gallate, a green tea polyphenol, induces expression of pim-1 kinase via PPARgamma in human vascular endothelial cells.	Polyphenols	42-52	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	76-81
23990052-0	2013	Epigallocatechin-3-O-gallate, a green tea polyphenol, induces expression of pim-1 kinase via PPARgamma in human vascular endothelial cells.	Polyphenols	42-52	peroxisome proliferator activated receptor gamma	Homo sapiens	93-102
23990052-3	2013	In this study, we sought to explore the expression of pim-1 in human vascular endothelial cells (ECs) and its regulation by epigallocatechin-3-O-gallate (EGCG), a green tea polyphenol which has anti-oxidant, anti-inflammatory and vascular protective effects.	Polyphenols	173-183	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	54-59
24021570-0	2013	Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells.	Polyphenols	0-11	AKT serine/threonine kinase 1	Homo sapiens	104-107
23975935-8	2013	Using complementary pharmacological and genetic approaches, we further demonstrate that NAD(+) and grape wine polyphenols prevent axonal apoptosis and act via mitochondrial SirT3 activation in axons.	Polyphenols	110-121	sirtuin 3	Homo sapiens	173-178
23943159-3	2013	Recently, integrin alphavbeta3 has been shown to have a panel of previously unappreciated small molecule receptor sites for thyroid hormone and hormone analogues, for dihydrotestosterone, and for resveratrol, a polyphenol that has certain estrogen-like features.	Polyphenols	211-221	integrin subunit alpha V	Homo sapiens	10-30
23790948-6	2013	The increases in UCP protein expression in two important thermogenic tissues after resveratrol treatment may contribute to increased whole-body energy dissipation, which may help to better understand the body-fat lowering effect of this polyphenol.	Polyphenols	237-247	uncoupling protein 1	Rattus norvegicus	17-20
24096034-0	2013	Green tea polyphenol, (-)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting beta-catenin signaling.	Polyphenols	10-20	catenin beta 1	Homo sapiens	111-123
23963285-1	2013	Red wine polyphenols (RWP) induce nitric oxide (NO) and endothelium-derived hyperpolarization (EDH)-mediated coronary vasodilatation involving the redox-sensitive PI3-kinase/Akt-dependent pathway in the endothelium.	Polyphenols	9-20	AKT serine/threonine kinase 1	Homo sapiens	174-177
23811288-0	2013	Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr-Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells.	Polyphenols	0-10	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	59-66
23811288-0	2013	Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr-Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells.	Polyphenols	0-10	signal transducer and activator of transcription 3	Homo sapiens	109-114
23811288-0	2013	Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr-Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells.	Polyphenols	0-10	signal transducer and activator of transcription 5A	Homo sapiens	115-120
24035895-3	2013	In this context, our present study examined three polyphenol compounds (curcumin, EGCG and resveratrol) for their possible activity against two endogenous proteins (BAG2 and LAMP1) that are shown to play a vital role in clearing tau tangles from neurons.	Polyphenols	50-60	BAG cochaperone 2	Rattus norvegicus	165-169
24035895-3	2013	In this context, our present study examined three polyphenol compounds (curcumin, EGCG and resveratrol) for their possible activity against two endogenous proteins (BAG2 and LAMP1) that are shown to play a vital role in clearing tau tangles from neurons.	Polyphenols	50-60	lysosomal-associated membrane protein 1	Rattus norvegicus	174-179
24035895-5	2013	Here, primary rat cortical neurons treated with these polyphenols significantly up-regulated BAG2 levels at different concentrations, while only EGCG upregulated LAMP1 levels, although at higher concentrations.	Polyphenols	54-65	BAG cochaperone 2	Rattus norvegicus	93-97
24035895-8	2013	The present results demonstrate novel activity of polyphenol curcumin in up-regulating an anti-tau cochaperone BAG2 and thus, suggest probable benefit of curcumin against AD-associated tauopathy.	Polyphenols	50-60	BAG cochaperone 2	Rattus norvegicus	111-115
23878368-2	2013	Resveratrol is a polyphenol, which in animal studies has been shown to decrease atherosclerosis, and improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signalling and through an improved antioxidant capacity.	Polyphenols	17-27	sirtuin 1	Homo sapiens	185-194
23129026-1	2013	Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation.	Polyphenols	17-27	sirtuin 1	Mus musculus	145-154
23129026-1	2013	Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation.	Polyphenols	17-27	sirtuin 1	Mus musculus	156-161
23830862-0	2013	3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside: implications in Alzheimer"s disease.	Polyphenols	78-88	amyloid beta precursor protein	Homo sapiens	42-54
23830862-4	2013	Thus inhibiting the formation of toxic Abeta assemblies is a reasonable hypothesis to prevent and perhaps treat AD METHODS: Solution NMR and molecular modeling were used to obtain more information about the interaction between the Abeta1-40 and the polyphenol epsilon-viniferin glucoside (EVG) and particularly the Abeta residues involved in the complex.	Polyphenols	249-259	amyloid beta precursor protein	Homo sapiens	39-44
23830862-4	2013	Thus inhibiting the formation of toxic Abeta assemblies is a reasonable hypothesis to prevent and perhaps treat AD METHODS: Solution NMR and molecular modeling were used to obtain more information about the interaction between the Abeta1-40 and the polyphenol epsilon-viniferin glucoside (EVG) and particularly the Abeta residues involved in the complex.	Polyphenols	249-259	amyloid beta precursor protein	Homo sapiens	231-236
23692748-8	2013	However, no single polyphenol was able to inhibit TF synthesis as efficiently as the crude grape extracts, unless it was combined with at least another compound, suggesting a synergism.	Polyphenols	19-29	coagulation factor III, tissue factor	Homo sapiens	50-52
23537522-12	2013	In conclusion, resveratrol reverses the change induced by high-fat feeding in the expression of Rev-Erbalpha in adipose tissue, which means that clock machinery is a target for this polyphenol.	Polyphenols	182-192	nuclear receptor subfamily 1, group D, member 1	Rattus norvegicus	96-108
23743621-8	2013	These findings suggest that induction of PON2 by quercetin represents an important mechanism by which this polyphenol may exert its neuroprotective action.	Polyphenols	107-117	paraoxonase 2	Mus musculus	41-45
23192879-6	2013	Interestingly, we identified the stress chaperone heat shock protein beta-1, a main protector of muscle necrosis, as a target of Oligopin  and showed that this polyphenol was able to modulate its stress induced phosphorylation.	Polyphenols	160-170	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	69-75
24066128-2	2013	In an effort to discover new small molecules able to inhibit the Hsp90 ATPase and chaperoning activities, we screened, by a surface plasmon resonance assay, a small library including different plant polyphenols.	Polyphenols	199-210	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-70
23782265-4	2013	This was in contrast with the action of traditional JAK/STAT3 inhibitors and the polyphenol resveratrol, which effectively suppress SOCS3 gene expression.	Polyphenols	81-91	suppressor of cytokine signaling 3	Homo sapiens	132-137
23835774-5	2013	Furin, the most studied proprotein convertase, was shown to be inhibited by polyphenols in an in vitro fluorescence peptide-based assay.	Polyphenols	76-87	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
23835774-8	2013	While direct inhibition by polyphenols of furin has, therefore, not been observed in cells, the existence of indirect mechanisms cannot be excluded.	Polyphenols	27-38	furin, paired basic amino acid cleaving enzyme	Homo sapiens	42-47
23835774-9	2013	In the present investigation, 26 polyphenols and 5 control compounds were screened for indirect inhibition of furin in a cellular environment.	Polyphenols	33-44	furin, paired basic amino acid cleaving enzyme	Homo sapiens	110-115
23835774-11	2013	The processing in cells of several genuine furin substrates, including pro-IGF-1R, appeared to be inhibited by these polyphenols.	Polyphenols	117-128	furin, paired basic amino acid cleaving enzyme	Homo sapiens	43-48
23835774-13	2013	The three polyphenols inhibited the maturation of the furin zymogen, thereby limiting the formation of the active enzyme.	Polyphenols	10-21	furin, paired basic amino acid cleaving enzyme	Homo sapiens	54-59
23835774-16	2013	Since, dependent of the molecular subclass of hepatocellular carcinoma, overexpression of furin can have either favourable or detrimental effects, it seems advisable to take indirect proprotein convertase inhibitory activity into account when polyphenols are considered for therapy of hepatocellular carcinoma.	Polyphenols	243-254	furin, paired basic amino acid cleaving enzyme	Homo sapiens	90-95
23643524-0	2013	Modulation of colonic inflammation in Mdr1a(-/-) mice by green tea polyphenols and their effects on the colon transcriptome and proteome.	Polyphenols	67-78	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	38-43
23830812-4	2013	Here we show that the pomegranate-derived polyphenols, punicalagin (PA) and ellagic acid (EA), inhibit MMP-13-mediated degradation of CII in vitro.	Polyphenols	42-53	matrix metallopeptidase 13	Rattus norvegicus	103-109
24051476-1	2013	Green tea, green tea polyphenols and epigallocatechin gallate (EGCG) are confirmed to have beneficial effects in the treatment of diabetes mellitus, and a possible mechanism can be ascribed to their inhibitory effect against alpha-amylase and alpha-glucosidase in the digestive tract.	Polyphenols	21-32	sucrase-isomaltase	Homo sapiens	243-260
24051476-2	2013	In this paper, we first investigated the combined inhibitory effect of green tea extracts, green tea polyphenols or EGCG with acarbose on alpha-amylase and alpha-glucosidase in vitro.	Polyphenols	101-112	sucrase-isomaltase	Homo sapiens	156-173
24051476-4	2013	The combination of green tea extracts, green tea polyphenols or EGCG with acarbose had a synergistic effect on alpha-amylase and alpha-glucosidase at low concentrations and the combined effect turned out to be antagonistic at high concentrations according to the Combination Index (CI) values.	Polyphenols	49-60	sucrase-isomaltase	Homo sapiens	129-146
23747345-2	2013	To identify new approaches to treat androgen-dependent prostate cancer, we have performed a structure-activity analysis of lignan polyphenols for cancer cell specific sensitization to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a death ligand that has ability to induce tumor-specific cell death.	Polyphenols	130-141	TNF superfamily member 10	Homo sapiens	184-239
23747345-2	2013	To identify new approaches to treat androgen-dependent prostate cancer, we have performed a structure-activity analysis of lignan polyphenols for cancer cell specific sensitization to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a death ligand that has ability to induce tumor-specific cell death.	Polyphenols	130-141	TNF superfamily member 10	Homo sapiens	241-246
23967153-10	2013	Thus, GSP reverses P-gp associated MDR by inhibiting the function and expression of P-gp through down-regulation of NF-kappaB activity and MAPK/ERK pathway mediated YB-1 nuclear translocation, offering insight into the mechanism of reversing MDR by natural polyphenol supplement compounds.	Polyphenols	257-267	GSM1	Homo sapiens	6-9
23967153-10	2013	Thus, GSP reverses P-gp associated MDR by inhibiting the function and expression of P-gp through down-regulation of NF-kappaB activity and MAPK/ERK pathway mediated YB-1 nuclear translocation, offering insight into the mechanism of reversing MDR by natural polyphenol supplement compounds.	Polyphenols	257-267	ATP binding cassette subfamily B member 1	Homo sapiens	19-23
23967153-10	2013	Thus, GSP reverses P-gp associated MDR by inhibiting the function and expression of P-gp through down-regulation of NF-kappaB activity and MAPK/ERK pathway mediated YB-1 nuclear translocation, offering insight into the mechanism of reversing MDR by natural polyphenol supplement compounds.	Polyphenols	257-267	ATP binding cassette subfamily B member 1	Homo sapiens	84-88
23938049-3	2013	Based on several in vitro, animal models and some human studies, dietary plant polyphenols and polyphenol-rich products modulate carbohydrate and lipid metabolism, attenuate hyperglycemia, dyslipidemia and insulin resistance, improve adipose tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and inflammatory processes.	Polyphenols	79-90	insulin	Homo sapiens	206-213
23967153-2	2013	Grape seed procyanidin(GSP) is a natural polyphenol supplement with anti-inflammatory effect.	Polyphenols	41-51	GSM1	Homo sapiens	23-26
23938049-3	2013	Based on several in vitro, animal models and some human studies, dietary plant polyphenols and polyphenol-rich products modulate carbohydrate and lipid metabolism, attenuate hyperglycemia, dyslipidemia and insulin resistance, improve adipose tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and inflammatory processes.	Polyphenols	79-89	insulin	Homo sapiens	206-213
23770099-2	2013	So far, its expression and thus its activity was suggested to be regulated at transcriptional level by LXR and PPAR agonists including polyphenols.	Polyphenols	135-146	peroxisome proliferator activated receptor alpha	Homo sapiens	111-115
23186731-0	2013	Cocoa polyphenols prevent inflammation in the colon of azoxymethane-treated rats and in TNF-alpha-stimulated Caco-2 cells.	Polyphenols	6-17	tumor necrosis factor	Rattus norvegicus	88-97
24244813-2	2013	Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells.	Polyphenols	46-57	insulin	Mesocricetus auratus	65-72
23733058-2	2013	One major class of polyphenols are the flavonoids and their formation is dependent on the enzyme chalcone synthase (CHS).	Polyphenols	19-30	polyketide synthase 5	Malus domestica	116-119
23186731-9	2013	Additionally, the experiments in Caco-2 cells confirm that cocoa polyphenols effectively down-regulate the levels of inflammatory markers induced by TNF-alpha by inhibiting NF-kappaB translocation and JNK phosphorylation.	Polyphenols	65-76	tumor necrosis factor	Rattus norvegicus	149-158
23870286-0	2013	Green tea polyphenols alleviate early BBB damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signaling.	Polyphenols	10-21	protein kinase C, alpha	Rattus norvegicus	132-140
23922719-0	2013	Black tea high-molecular-weight polyphenol stimulates exercise training-induced improvement of endurance capacity in mouse via the link between AMPK and GLUT4.	Polyphenols	32-42	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	153-158
23922719-2	2013	Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise training could run longer distances and for a longer time compared with the exercise only group; MAF is a high-molecular-weight polyphenol purified from black tea.	Polyphenols	226-236	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	38-68
23922719-2	2013	Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise training could run longer distances and for a longer time compared with the exercise only group; MAF is a high-molecular-weight polyphenol purified from black tea.	Polyphenols	226-236	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	70-73
23922719-2	2013	Here, we found that mice administered Mitochondria Activation Factor (MAF) combined with exercise training could run longer distances and for a longer time compared with the exercise only group; MAF is a high-molecular-weight polyphenol purified from black tea.	Polyphenols	226-236	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	195-198
23923070-0	2013	Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues.	Polyphenols	4-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	67-70
23863773-1	2013	Novel tea catechin derivatives have been synthesized, and a structure-activity study, related to the capacity of these and other polyphenols to bind dihydrofolate reductase (DHFR), has been performed.	Polyphenols	129-140	dihydrofolate reductase	Homo sapiens	149-172
23863773-1	2013	Novel tea catechin derivatives have been synthesized, and a structure-activity study, related to the capacity of these and other polyphenols to bind dihydrofolate reductase (DHFR), has been performed.	Polyphenols	129-140	dihydrofolate reductase	Homo sapiens	174-178
23863773-3	2013	Polyphenols with a catechin configuration were better DHFR inhibitors than those with an epicatechin configuration.	Polyphenols	0-11	dihydrofolate reductase	Homo sapiens	54-58
23923070-0	2013	Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues.	Polyphenols	4-15	BCL2, apoptosis regulator	Rattus norvegicus	75-80
23923070-11	2013	At the same time, tea polyphenols treatment enhanced p53 expression, but reduced bcl-2 expression.	Polyphenols	22-33	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	53-56
23923070-11	2013	At the same time, tea polyphenols treatment enhanced p53 expression, but reduced bcl-2 expression.	Polyphenols	22-33	BCL2, apoptosis regulator	Rattus norvegicus	81-86
23923070-12	2013	These results indicated that tea polyphenols may have preventive effect against lung preneoplasm lesions, possibly through regulating the expression of some critical genes such as p53 and bcl-2.	Polyphenols	33-44	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	180-183
23923070-12	2013	These results indicated that tea polyphenols may have preventive effect against lung preneoplasm lesions, possibly through regulating the expression of some critical genes such as p53 and bcl-2.	Polyphenols	33-44	BCL2, apoptosis regulator	Rattus norvegicus	188-193
23816049-0	2013	Oral supplementation with areca-derived polyphenols attenuates food allergic responses in ovalbumin-sensitized mice.	Polyphenols	40-51	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	90-99
23840454-9	2013	Altogether, we suggest that green tea polyphenols could serve as reagents for treatment or prevention of leukemia harboring FLT3 mutations.	Polyphenols	38-49	fms related receptor tyrosine kinase 3	Homo sapiens	124-128
23361943-0	2013	Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract: interactions with SGLT1 and GLUT2 transporters.	Polyphenols	68-78	solute carrier family 5 member 1	Homo sapiens	118-123
23361943-0	2013	Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract: interactions with SGLT1 and GLUT2 transporters.	Polyphenols	68-78	solute carrier family 2 member 2	Homo sapiens	128-133
23474323-6	2013	Processing flour into PRMP led to a significant (p&lt;0.05) reduction of tannins (50%), total polyphenols (50%) and trypsin inhibitors (94%).	Polyphenols	94-105	shisa family member 4	Rattus norvegicus	22-26
23355380-7	2013	The main polyphenols found in the propolis extract, artepillin C, coumaric acid, and kaempferide, promoted GLUT4 translocation in L6 myotubes.	Polyphenols	9-20	solute carrier family 2 member 4	Rattus norvegicus	107-112
23022493-8	2013	Our findings suggest that treatment with polyphenols such as RSV can be used as a potential regulatory strategy for MsrA expression and function.	Polyphenols	41-52	methionine sulfoxide reductase A	Homo sapiens	116-120
23683106-1	2013	Black soybean seed coat has abundant levels of polyphenols such as anthocyanins (cyanidin 3-glucoside; C3G) and procyanidins (PCs).	Polyphenols	47-58	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	103-106
23755172-10	2014	Green tea polyphenols alone and following CsA increased AS-beta, ND3, COX-IV, mtDNA copy number, PGC-1alpha mRNA and protein, decreased acetylated PGC-1alpha, and increased Tfam mRNA and protein.	Polyphenols	10-21	arylsulfatase B	Rattus norvegicus	56-63
23755172-10	2014	Green tea polyphenols alone and following CsA increased AS-beta, ND3, COX-IV, mtDNA copy number, PGC-1alpha mRNA and protein, decreased acetylated PGC-1alpha, and increased Tfam mRNA and protein.	Polyphenols	10-21	PPARG coactivator 1 alpha	Rattus norvegicus	97-107
23755172-10	2014	Green tea polyphenols alone and following CsA increased AS-beta, ND3, COX-IV, mtDNA copy number, PGC-1alpha mRNA and protein, decreased acetylated PGC-1alpha, and increased Tfam mRNA and protein.	Polyphenols	10-21	PPARG coactivator 1 alpha	Rattus norvegicus	147-157
23755172-10	2014	Green tea polyphenols alone and following CsA increased AS-beta, ND3, COX-IV, mtDNA copy number, PGC-1alpha mRNA and protein, decreased acetylated PGC-1alpha, and increased Tfam mRNA and protein.	Polyphenols	10-21	transcription factor A, mitochondrial	Rattus norvegicus	173-177
23317012-6	2013	Tea polyphenols may provide anti-atherosclerotic effects by inhibiting LDL oxidation through EC-SOD bound to the endothelium.	Polyphenols	4-15	superoxide dismutase 3	Homo sapiens	93-99
23668856-0	2013	Polyphenols protect the epithelial barrier function of Caco-2 cells exposed to indomethacin through the modulation of occludin and zonula occludens-1 expression.	Polyphenols	0-11	occludin	Homo sapiens	118-126
23275372-0	2013	Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.	Polyphenols	6-17	insulin	Homo sapiens	64-71
23411172-0	2013	Apple polyphenols suppress antigen presentation of ovalbumin by THP-1-derived dendritic cells.	Polyphenols	6-17	GLI family zinc finger 2	Homo sapiens	64-69
23411228-5	2013	Moreover, these polyphenols up-regulated xenobiotic metabolizing enzymes UGT1A10 and CYP1A1, enhancing carcinogen detoxification.	Polyphenols	16-27	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	73-80
23411228-5	2013	Moreover, these polyphenols up-regulated xenobiotic metabolizing enzymes UGT1A10 and CYP1A1, enhancing carcinogen detoxification.	Polyphenols	16-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	85-91
23548906-10	2013	Given that MSCs are recruited within vascularizing tumors and are believed to contribute to tumor angiogenesis, possibly through secretion of CSF-2 and CSF-3, our study suggests that diet-derived polyphenols such as EGCG may exert chemopreventive action through pharmacological targeting of the MT1-MMP intracellular signaling.	Polyphenols	196-207	colony stimulating factor 2	Homo sapiens	142-147
23614772-0	2013	alpha-Amylase inhibitory activity from nut seed skin polyphenols.	Polyphenols	53-64	LOW QUALITY PROTEIN: pancreatic alpha-amylase	Sus scrofa	0-13
23614772-8	2013	The results suggest almond seed skin contains highly polymerized polyphenols with strong alpha-amylase inhibitory activity, which retard absorption of carbohydrate.	Polyphenols	65-76	LOW QUALITY PROTEIN: pancreatic alpha-amylase	Sus scrofa	89-102
23548308-3	2013	It regulates nuclear functions such as chromatin remodelling and gene transcription, and it appears to mediate beneficial effects of a low calorie diet which can partly be mimicked by the Sirt1 activating polyphenol resveratrol.	Polyphenols	205-215	sirtuin 1	Homo sapiens	188-193
23548906-10	2013	Given that MSCs are recruited within vascularizing tumors and are believed to contribute to tumor angiogenesis, possibly through secretion of CSF-2 and CSF-3, our study suggests that diet-derived polyphenols such as EGCG may exert chemopreventive action through pharmacological targeting of the MT1-MMP intracellular signaling.	Polyphenols	196-207	colony stimulating factor 3	Homo sapiens	152-157
23548906-10	2013	Given that MSCs are recruited within vascularizing tumors and are believed to contribute to tumor angiogenesis, possibly through secretion of CSF-2 and CSF-3, our study suggests that diet-derived polyphenols such as EGCG may exert chemopreventive action through pharmacological targeting of the MT1-MMP intracellular signaling.	Polyphenols	196-207	matrix metallopeptidase 14	Homo sapiens	295-302
22898567-2	2013	We assumed that curcumin, a polyphenol, would attenuate the tissue dyslipidemic condition through activation of 5" adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and suppression of sterol regulatory element-binding protein (SREBP)-1c in the kidney and would prevent renal progression in experimental type 1 diabetic rats.	Polyphenols	28-38	sterol regulatory element binding transcription factor 1	Rattus norvegicus	212-264
23461657-0	2013	A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.	Polyphenols	10-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	106-110
23461657-0	2013	A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.	Polyphenols	10-20	sirtuin 1	Rattus norvegicus	115-120
23461657-1	2013	Polyphenol resveratrol (RSV) has been associated with Silent Information Regulator T1 (SIRT1) and AMP-activated protein kinase (AMPK) metabolic stress sensors and probably responds to the intracellular energy status.	Polyphenols	0-10	sirtuin 1	Rattus norvegicus	54-85
23461657-1	2013	Polyphenol resveratrol (RSV) has been associated with Silent Information Regulator T1 (SIRT1) and AMP-activated protein kinase (AMPK) metabolic stress sensors and probably responds to the intracellular energy status.	Polyphenols	0-10	sirtuin 1	Rattus norvegicus	87-92
23461657-1	2013	Polyphenol resveratrol (RSV) has been associated with Silent Information Regulator T1 (SIRT1) and AMP-activated protein kinase (AMPK) metabolic stress sensors and probably responds to the intracellular energy status.	Polyphenols	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	98-126
23461657-1	2013	Polyphenol resveratrol (RSV) has been associated with Silent Information Regulator T1 (SIRT1) and AMP-activated protein kinase (AMPK) metabolic stress sensors and probably responds to the intracellular energy status.	Polyphenols	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	128-132
23468550-10	2013	Cell culture experiments verified that 2 polyphenol components of pomegranate extract, punicalagin and ellagic acid, attenuated NFAT activity in a reporter cell line (P < 0.05) and decreased Abeta-stimulated TNF-alpha secretion by murine microglia (P < 0.05).	Polyphenols	41-51	amyloid beta (A4) precursor protein	Mus musculus	191-196
23658797-5	2013	However, lipophilic antioxidant polyphenols in plants, which are poorly soluble in water and therefore not fully available as effective antioxidants, can nevertheless be solubilized either by small amounts of ethanol, whole saliva or also by salivary albumin and mucin.	Polyphenols	32-43	LOC100508689	Homo sapiens	263-268
25206725-6	2013	Terminal deoxynucleotidyl transferase-mediated nick end labeling and flow cytometry showed that 200 mg/kg tea polyphenols significantly reduced the number and percentage of apoptotic cells in the hippocampal CA1 region of rats after cerebral ischemia/reperfusion injury.	Polyphenols	110-121	DNA nucleotidylexotransferase	Rattus norvegicus	0-37
23537203-2	2013	The polyphenol (-)-epigallocatechin gallate (EGCG) was recently reported to inhibit Abeta fibrillization and redirect Abeta aggregation into unstructured, off-pathway oligomers.	Polyphenols	4-14	amyloid beta precursor protein	Homo sapiens	84-89
23537203-2	2013	The polyphenol (-)-epigallocatechin gallate (EGCG) was recently reported to inhibit Abeta fibrillization and redirect Abeta aggregation into unstructured, off-pathway oligomers.	Polyphenols	4-14	amyloid beta precursor protein	Homo sapiens	118-123
23466052-0	2013	Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain.	Polyphenols	17-28	nerve growth factor	Mus musculus	47-66
23466052-0	2013	Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain.	Polyphenols	17-28	brain derived neurotrophic factor	Mus musculus	71-104
23466052-11	2013	CONCLUSIONS: Altogether, this study shows that olive polyphenols in the mouse may increase the levels of NGF and BDNF in crucial areas of the limbic system and olfactory bulbs, which play a key role in learning and memory processes and in the proliferation and migration of endogenous progenitor cells present in the rodent brain.	Polyphenols	53-64	nerve growth factor	Mus musculus	105-108
23466052-11	2013	CONCLUSIONS: Altogether, this study shows that olive polyphenols in the mouse may increase the levels of NGF and BDNF in crucial areas of the limbic system and olfactory bulbs, which play a key role in learning and memory processes and in the proliferation and migration of endogenous progenitor cells present in the rodent brain.	Polyphenols	53-64	brain derived neurotrophic factor	Mus musculus	113-117
23468550-10	2013	Cell culture experiments verified that 2 polyphenol components of pomegranate extract, punicalagin and ellagic acid, attenuated NFAT activity in a reporter cell line (P < 0.05) and decreased Abeta-stimulated TNF-alpha secretion by murine microglia (P < 0.05).	Polyphenols	41-51	tumor necrosis factor	Mus musculus	208-217
23684442-0	2013	Aronia melanocarpa (chokeberry) polyphenol-rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice.	Polyphenols	32-42	apolipoprotein E	Mus musculus	126-142
23684442-1	2013	We hypothesized that a polyphenol-rich chokeberry extract (CBE) would modulate hepatic lipid metabolism and improve antioxidant function in apolipoprotein E knockout (apoE(-/-)) mice.	Polyphenols	23-33	apolipoprotein E	Mus musculus	140-156
23439031-3	2013	AIM OF THE STUDY: The polyphenol-rich extract, CSD3, from Chaenomeles sinensis has previously been shown to neutralize influenza virus infectivity.	Polyphenols	22-32	transforming growth factor beta induced	Homo sapiens	47-51
22999066-10	2013	CONCLUSIONS: These results support a beneficial effect of the non-alcoholic fraction of red wine (mainly polyphenols) on insulin resistance, conferring greater protective effects on cardiovascular disease to red wine than other alcoholic beverages.	Polyphenols	105-116	insulin	Homo sapiens	121-128
22641065-0	2013	Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor.	Polyphenols	6-17	insulin receptor	Mus musculus	82-98
25206725-6	2013	Terminal deoxynucleotidyl transferase-mediated nick end labeling and flow cytometry showed that 200 mg/kg tea polyphenols significantly reduced the number and percentage of apoptotic cells in the hippocampal CA1 region of rats after cerebral ischemia/reperfusion injury.	Polyphenols	110-121	carbonic anhydrase 1	Rattus norvegicus	208-211
23671928-7	2013	GENERAL SIGNIFICANCE: This study provides information to better understand the molecular mechanisms underlying the biological activities of catechins and to design new polyphenol-based ERp57-specific inhibitors.	Polyphenols	168-178	protein disulfide isomerase family A member 3	Homo sapiens	185-190
22721439-5	2013	The aqueous extract of Hibiscus Sabdariffa L (HSE), rich in several polyphenols, is commonly and effectively used in native medicines against hypertension, diabetes and liver disorders.	Polyphenols	68-79	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	46-49
22956389-8	2013	The ADA activity and platelet aggregation were reduced in platelets of diabetic rats in the presence of all polyphenols tested in vitro.	Polyphenols	108-119	adenosine deaminase	Rattus norvegicus	4-7
23222814-6	2013	However, simultaneous exposure to BPA and the polyphenol, curcumin, partially or fully reduced the spectrum of effects associated with BPA alone, including mTOR pathway proteins (AKT1, RPS6, pRPS6 and 4EBP1).	Polyphenols	46-56	mechanistic target of rapamycin kinase	Homo sapiens	156-160
23222814-6	2013	However, simultaneous exposure to BPA and the polyphenol, curcumin, partially or fully reduced the spectrum of effects associated with BPA alone, including mTOR pathway proteins (AKT1, RPS6, pRPS6 and 4EBP1).	Polyphenols	46-56	AKT serine/threonine kinase 1	Homo sapiens	179-183
23222814-6	2013	However, simultaneous exposure to BPA and the polyphenol, curcumin, partially or fully reduced the spectrum of effects associated with BPA alone, including mTOR pathway proteins (AKT1, RPS6, pRPS6 and 4EBP1).	Polyphenols	46-56	ribosomal protein S6	Homo sapiens	185-189
22721439-6	2013	HSE has also shown therapeutic promise in the prevention of MS in patients, probably due to its polyphenol content.	Polyphenols	96-106	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	0-3
23276205-4	2013	In this surface plasmon resonance imaging (SPRi) study, we have shown that the fibril seeds formed with the incubation of Abeta in the presence of metals are better at promoting monomer elongation compared to Abeta alone or in the presence of a well-described polyphenol, (-)-epigallocatechin-3-gallate (EGCG).	Polyphenols	260-270	amyloid beta precursor protein	Homo sapiens	122-127
23325921-8	2013	These results suggest that addition of polyphenols during active digestion can limit the development of (n-3) PUFA oxidation products in the small intestine lumen and thereby promote intestinal uptake of the beneficial, unoxidized, (n-3) PUFAs.	Polyphenols	39-50	pumilio RNA binding family member 3	Homo sapiens	110-114
23662249-4	2013	Here, we studied the effect of natural polyphenols resveratrol, curcumin, quercetin and analogs on LSD1.	Polyphenols	39-50	lysine demethylase 1A	Homo sapiens	99-103
23349077-1	2013	SCOPE: Increasing evidence indicates that polyphenols may protect against metabolic disease through activating AMP-activated protein kinase (AMPK).	Polyphenols	42-53	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	141-145
23274094-9	2013	The polyphenol activated AMPK and PGC-1alpha.	Polyphenols	4-14	PPARG coactivator 1 alpha	Rattus norvegicus	34-44
23072830-7	2013	Finally, all specimens containing polyphenols efficiently inhibited the MPO activity.	Polyphenols	34-45	myeloperoxidase	Homo sapiens	72-75
23231502-10	2013	Recent studies indicate that Pin1 is an important molecular target for the chemopreventive effects of green tea polyphenols.	Polyphenols	112-123	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	29-33
23025298-6	2013	One possible protective molecular mechanism of polyphenols is nuclear factor erythroid 2-related factor (Nrf2) activation, which in turn regulates a number of detoxification enzymes.	Polyphenols	47-58	NFE2 like bZIP transcription factor 2	Homo sapiens	62-103
23025298-6	2013	One possible protective molecular mechanism of polyphenols is nuclear factor erythroid 2-related factor (Nrf2) activation, which in turn regulates a number of detoxification enzymes.	Polyphenols	47-58	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
23025298-7	2013	RECENT ADVANCES: Among the latter, the heme oxygenase-1 (HO-1) pathway is likely to contribute to the established and powerful antioxidant/anti-inflammatory properties of polyphenols.	Polyphenols	171-182	heme oxygenase 1	Homo sapiens	39-55
23025298-7	2013	RECENT ADVANCES: Among the latter, the heme oxygenase-1 (HO-1) pathway is likely to contribute to the established and powerful antioxidant/anti-inflammatory properties of polyphenols.	Polyphenols	171-182	heme oxygenase 1	Homo sapiens	57-61
23370395-5	2013	Here, we explore the AMPK/mTOR-xenohormetic nature of complex polyphenols naturally present in extra virgin olive oil (EVOO), a pivotal component of the Mediterranean style diet that has been repeatedly associated with a reduction in age-related morbid conditions and longer life expectancy.	Polyphenols	62-73	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	21-25
23231348-0	2013	Polyphenols can inhibit furin in vitro as a result of the reactivity of their auto-oxidation products to proteins.	Polyphenols	0-11	furin, paired basic amino acid cleaving enzyme	Homo sapiens	24-29
23168232-6	2013	The hTAS2R38 genotype affected the liking of polyphenol-rich extracts, which were significantly bitter and astringent.	Polyphenols	45-55	taste 2 receptor member 38	Homo sapiens	4-12
23276449-2	2013	Curcumin (CM), a turmeric-derived bioactive polyphenol found in curry, has recently been identified as a ligand for the vitamin D receptor (VDR), and it is possible that CM exerts some of its bioeffects via direct binding to VDR and/or other proteins in the nuclear receptor superfamily.	Polyphenols	44-54	vitamin D receptor	Homo sapiens	140-143
23231348-10	2013	Adding glutathione to the detergent-based assay, as used in these studies to measure furin processing activity, strongly reduced inhibition by a number of polyphenols (catechins, gallic acid and quercetin), while the effect on the genuine inhibitor nona-D-arginine remained unchanged.	Polyphenols	155-166	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
22903980-11	2013	The present data indicate that regular intake of PPs starting at a young age prevents age-related mitochondrial respiratory impairment in skeletal muscle, probably through decreased oxidative stress and enhancement of PGC-1beta expression.	Polyphenols	49-52	PPARG coactivator 1 beta	Rattus norvegicus	218-227
22382203-0	2013	Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells.	Polyphenols	0-10	bone gamma-carboxyglutamate protein	Homo sapiens	107-118
24362981-3	2013	The most relevant structural features for the lipophilicity of polyphenols are depicted by the statistically most significant variables: the number of donor atoms for the H bonds is unfavorable for lipophilicity, and the enhanced number of ring secondary C atom (sp3) also decreases lipophilicity, while the increased atomic polarizability implies higher lipophilicity of polyphenols.	Polyphenols	63-74	Sp3 transcription factor	Homo sapiens	263-266
23348740-5	2013	Furthermore, upregulation of cGMP was a rate-determining process of 67LR-dependent cell death induced by the green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG), a natural ligand of 67LR.	Polyphenols	119-129	ribosomal protein SA	Mus musculus	68-72
23348740-5	2013	Furthermore, upregulation of cGMP was a rate-determining process of 67LR-dependent cell death induced by the green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG), a natural ligand of 67LR.	Polyphenols	119-129	ribosomal protein SA	Mus musculus	191-195
23440625-4	2013	Both polyphenols proved to have anti-inflammatory activity as evidenced by the decreased nitric oxide (NO), cytokines (IL-1beta , IL-6, and IL-10) and prostaglandin E2 (PGE(2)) levels in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages.	Polyphenols	5-16	interleukin 1 beta	Mus musculus	119-127
23440625-4	2013	Both polyphenols proved to have anti-inflammatory activity as evidenced by the decreased nitric oxide (NO), cytokines (IL-1beta , IL-6, and IL-10) and prostaglandin E2 (PGE(2)) levels in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages.	Polyphenols	5-16	interleukin 6	Mus musculus	130-134
23440625-4	2013	Both polyphenols proved to have anti-inflammatory activity as evidenced by the decreased nitric oxide (NO), cytokines (IL-1beta , IL-6, and IL-10) and prostaglandin E2 (PGE(2)) levels in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages.	Polyphenols	5-16	interleukin 10	Mus musculus	140-145
27481281-0	2013	Molecular Dynamics Investigation on the Inhibition of MDM2-p53 Interaction by Polyphenols.	Polyphenols	78-89	MDM2 proto-oncogene	Homo sapiens	54-58
27481281-0	2013	Molecular Dynamics Investigation on the Inhibition of MDM2-p53 Interaction by Polyphenols.	Polyphenols	78-89	tumor protein p53	Homo sapiens	59-62
23122108-0	2013	Maple polyphenols, ginnalins A-C, induce S- and G2/M-cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels.	Polyphenols	6-17	cyclin A2	Homo sapiens	127-143
23192662-0	2013	Overexpression of miR-7-1 increases efficacy of green tea polyphenols for induction of apoptosis in human malignant neuroblastoma SH-SY5Y and SK-N-DZ cells.	Polyphenols	58-69	microRNA 7-1	Homo sapiens	18-25
23192662-8	2013	Our data also demonstrated that overexpression of miR-93 decreased efficacy while overexpression of miR-7-1 increased efficacy of the green tea polyphenols for induction of apoptosis in both cell lines.	Polyphenols	144-155	microRNA 7-1	Homo sapiens	100-107
24362981-3	2013	The most relevant structural features for the lipophilicity of polyphenols are depicted by the statistically most significant variables: the number of donor atoms for the H bonds is unfavorable for lipophilicity, and the enhanced number of ring secondary C atom (sp3) also decreases lipophilicity, while the increased atomic polarizability implies higher lipophilicity of polyphenols.	Polyphenols	372-383	Sp3 transcription factor	Homo sapiens	263-266
23722097-5	2013	This chapter focuses on four important food groups such as cereals, legumes, fruits, and spices that have active ingredients such as soluble dietary fiber, polyphenols, and antinutrients with the ability to reduce glycemic and insulin response in humans.	Polyphenols	156-167	insulin	Homo sapiens	227-234
23370353-2	2013	Polyphenols have been reported to inhibit steroidogenic enzymes such as 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and aromatase.	Polyphenols	0-11	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	72-106
23370353-2	2013	Polyphenols have been reported to inhibit steroidogenic enzymes such as 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and aromatase.	Polyphenols	0-11	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	108-117
23103157-0	2013	Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol.	Polyphenols	110-120	elastin	Homo sapiens	71-78
23103157-5	2013	Pre-implantation treatment of collagen and elastin scaffolds with penta-galloyl glucose (PGG), an antioxidant and matrix-binding polyphenol, chemically stabilized the scaffolds, reduced their enzymatic degradation, and protected them from diabetes-related complications by reduction of scaffold-bound AGE levels.	Polyphenols	129-139	elastin	Homo sapiens	43-50
23210776-9	2013	The feasibility of PPs to prevent/ cure specific cutaneous toxicity connected to anti-EGFR therapy and to reduce multidrug resistance of skin tumors is also discussed.	Polyphenols	19-22	epidermal growth factor receptor	Homo sapiens	86-90
24066014-0	2013	Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II.	Polyphenols	14-25	angiotensinogen	Rattus norvegicus	133-147
23935691-2	2013	Polyphenols rich extracts derived from waste water from olive mill, obtained by a molecular imprinting approach, have been investigated in order to discover compounds able to reduce IL-8 expression in human bronchial epithelial cells (IB3-1 cells), derived from a CF patient with a DeltaF508/W1282X mutant genotype and stimulated with TNF-alpha.	Polyphenols	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
23127600-6	2013	These findings demonstrate that cinnamon polyphenols can exert the hypoglycemic and hypolipidemic effects through the mechanisms that may be associated with repairing pancreatic beta cells in diabetic mice and improving its anti-oxidative capacity, as well as attenuating cytotoxicity via inhibition of iNOS, NF-kappaB activation.	Polyphenols	41-52	nitric oxide synthase 2, inducible	Mus musculus	303-307
23573148-0	2013	Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells.	Polyphenols	0-11	TNF superfamily member 10	Homo sapiens	43-48
23573148-8	2013	EEP and polyphenols isolated from propolis have been shown to sensitize cancer cells to TRAIL-induced apoptosis.	Polyphenols	8-19	TNF superfamily member 10	Homo sapiens	88-93
23125162-2	2013	Some polyphenols have insulin-potentiating and anti-inflammatory effects, both of which are important in obesity.	Polyphenols	5-16	insulin	Homo sapiens	22-29
23724859-3	2013	In vitro studies using Caco-2 cells have shown that some polyphenols (quercetin, genistein, resveratrol) may impair OTA efflux through competitive inhibition of MRP2, possibly resulting in an increased systemic availability of OTA.	Polyphenols	57-68	ATP binding cassette subfamily C member 2	Homo sapiens	161-165
23476753-0	2013	Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells.	Polyphenols	6-17	histone deacetylase 9	Homo sapiens	96-115
23476753-4	2013	The polyphenols (-)-epigallocatechin-3-gallate (EGCG) and genistein (GEN) as well as two oxidative methyleugenol (ME) metabolites were shown to inhibit HDAC activity in intact HT29 cells.	Polyphenols	4-15	histone deacetylase 9	Homo sapiens	152-156
23849860-9	2013	Finally, as an example, we describe the methods used to demonstrate the role of H2O2-mediated cell signaling of PKCe in green tea polyphenol-induced preconditioning against neuronal cell death caused by oxygen-glucose deprivation and reoxygenation, an in vitro model for cerebral ischemic/reperfusion injury.	Polyphenols	130-140	protein kinase C epsilon	Homo sapiens	112-116
23165995-5	2013	Evidence is building that polyphenols can target specific miRNAs, such as miR-122, but more studies are necessary to discover and validate additional miRNA targets.	Polyphenols	26-37	microRNA 122	Homo sapiens	74-81
23022120-2	2013	The aim of this study was to examine whether maternal azuki bean (Vigna angularis) polyphenol (AP) intake during lactation affects the adenosine monophosphate-activated protein kinase (AMPK) pathway and lipid metabolism in offspring exposed to fetal malnutrition.	Polyphenols	83-93	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	185-189
23064431-2	2013	In the last decades, a series of compounds, including quinones and polyphenols, has been described as having anti-fibrillogenic action on alpha-synuclein (alpha-syn) whose aggregation is associated to the pathogenesis of Parkinson"s disease (PD).	Polyphenols	67-78	synuclein alpha	Homo sapiens	138-153
23064431-2	2013	In the last decades, a series of compounds, including quinones and polyphenols, has been described as having anti-fibrillogenic action on alpha-synuclein (alpha-syn) whose aggregation is associated to the pathogenesis of Parkinson"s disease (PD).	Polyphenols	67-78	synuclein alpha	Homo sapiens	138-147
23840920-1	2013	Tea polyphenols are of great benefit to the treatment of several neurodegenerative diseases.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
23840920-2	2013	In order to explore the neuroprotective effects of tea polyphenols and their potential mechanisms, an established in vivo subarachnoid hemorrhage (SAH) model was used and alterations of mitochondrial function, ATP content, and cytochrome c (cyt c) in cerebral cortex were detected.	Polyphenols	55-66	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	51-54
23840920-7	2013	After pretreatment with tea polyphenols, the neurological outcome was also improved.	Polyphenols	28-39	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	24-27
23840920-8	2013	The results provide strong evidence that tea polyphenols enhance neuroprotective effects by inhibiting polarization of mitochondrial membrane potential, increasing ATP content, and blocking cyt c release.	Polyphenols	45-56	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	41-44
24069505-6	2013	Interestingly, when compared to calorie restriction which has been repeatedly shown to increase healthspan, these polyphenols activate similar molecular targets such as Sirt1.	Polyphenols	114-125	sirtuin 1	Homo sapiens	169-174
23840922-7	2013	In particular, signaling pathways like PPAR, Nrf2, STAT, HIF, and MAPK along with modulation of immune response by polyphenols are discussed.	Polyphenols	115-126	peroxisome proliferator activated receptor alpha	Homo sapiens	39-43
23840922-7	2013	In particular, signaling pathways like PPAR, Nrf2, STAT, HIF, and MAPK along with modulation of immune response by polyphenols are discussed.	Polyphenols	115-126	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
24363823-0	2013	Antigenotoxic and apoptotic activity of green tea polyphenol extracts on hexavalent chromium-induced DNA damage in peripheral blood of CD-1 mice: analysis with differential acridine orange/ethidium bromide staining.	Polyphenols	50-60	CD1 antigen complex	Mus musculus	135-139
23844275-8	2013	Interestingly, significant correlation was observed between AOA (DPPH and FRAP) and PC in most of the foods, corroborating the literature that polyphenols are potent antioxidants and that they may be important contributors to the AOA of the plant foods.	Polyphenols	143-154	mechanistic target of rapamycin kinase	Homo sapiens	74-78
23342006-0	2013	Green tea polyphenols reduced fat deposits in high fat-fed rats via erk1/2-PPARgamma-adiponectin pathway.	Polyphenols	10-21	mitogen activated protein kinase 3	Rattus norvegicus	68-74
23516517-3	2013	In the present study, we searched for novel potent small molecule inhibitors of KCa3.1 by testing a series of 20 selected natural and synthetic (poly)phenols, synthetic benzoic acids, and non-steroidal anti-inflammatory drugs (NSAIDs), with known cytoprotective, anti-inflammatory, and/or cytostatic activities.	Polyphenols	144-157	potassium calcium-activated channel subfamily N member 4	Homo sapiens	80-86
23520540-4	2013	There is increasing evidence to suggest that natural polyphenols may prevent the formation of toxic amyloid aggregates; this applies also to oleuropein aglycone (OLE), the most abundant polyphenol in extra virgin olive oil, previously shown to hinder amylin and Abeta aggregation.	Polyphenols	53-64	amyloid beta precursor protein	Homo sapiens	262-267
23520540-4	2013	There is increasing evidence to suggest that natural polyphenols may prevent the formation of toxic amyloid aggregates; this applies also to oleuropein aglycone (OLE), the most abundant polyphenol in extra virgin olive oil, previously shown to hinder amylin and Abeta aggregation.	Polyphenols	53-63	amyloid beta precursor protein	Homo sapiens	262-267
23342006-0	2013	Green tea polyphenols reduced fat deposits in high fat-fed rats via erk1/2-PPARgamma-adiponectin pathway.	Polyphenols	10-21	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	75-84
23342006-0	2013	Green tea polyphenols reduced fat deposits in high fat-fed rats via erk1/2-PPARgamma-adiponectin pathway.	Polyphenols	10-21	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	85-96
23342006-2	2013	In this study we investigated the effects of green tea polyphenols (GTPs) on adiponectin levels and fat deposits in high fat (HF) fed rats, the mechanism of signaling pathway was explored as well.	Polyphenols	55-66	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	77-88
23205879-4	2012	Here the inhibition mechanism of green tea polyphenols, catechins, on amyloid fibril formation of the IAPP fragment (IAPP22-27), which is of sufficient length for formation of beta-sheet-containing amyloid fibrils, was investigated by means of kinetic analysis.	Polyphenols	43-54	islet amyloid polypeptide	Homo sapiens	102-106
22219517-1	2012	BACKGROUND: Resveratrol, a plant-derived polyphenol, has shown promising effects on insulin sensitivity and glucose tolerance in animal models and is also reported to have cardioprotective properties, but human studies are limited.	Polyphenols	41-51	insulin	Homo sapiens	84-91
22929970-3	2012	With an emphasis on neurodegenerative conditions, such as Alzheimer"s disease, we highlight recent findings on the neuroprotection ascribed to bioactive polyphenols capable of directly interfering with the Alzheimer"s disease hallmark toxic beta-amyloid protein (Abeta), thereby inhibiting fibril and aggregate formation.	Polyphenols	153-164	amyloid beta precursor protein	Homo sapiens	263-268
22980822-0	2012	Interactions of different polyphenols with bovine serum albumin using fluorescence quenching and molecular docking.	Polyphenols	26-37	albumin	Homo sapiens	50-63
23042094-3	2012	We previously reported that the chemopreventive polyphenol curcumin inhibits the expression of the proinflammatory cytokines CXCL1 and -2 leading to diminished formation of breast cancer metastases.	Polyphenols	48-58	C-X-C motif chemokine ligand 1	Homo sapiens	125-137
22953807-1	2012	Polyphenol-rich extracts from certain berries inhibited alpha-glucosidase activity in vitro.	Polyphenols	0-10	sucrase-isomaltase	Homo sapiens	56-73
21895782-8	2012	Thus, polyphenol-rich GSGM meal-based feed additives may be useful for the inhibition or prevention of inflammatory processes in the intestine of livestock animals, in particular during states with inappropriate NF-kappaB activation in the intestinal tissue, such as the weaning phase.	Polyphenols	6-16	nuclear factor kappa B subunit 1	Homo sapiens	212-221
22796566-4	2012	A variety of dietary polyphenols and pharmacological activators are shown to regulate SIRT1 so as to intervene the progression of type 2 diabetes, cancer, cardiovascular diseases, and chronic obstructive pulmonary disease associated with inflammaging.	Polyphenols	21-32	sirtuin 1	Homo sapiens	86-91
22796566-5	2012	However, recent studies have shown the non-specific regulation of SIRT1 by the aforementioned pharmacological activators and polyphenols.	Polyphenols	125-136	sirtuin 1	Homo sapiens	66-71
22932898-2	2012	We recently showed that Bmi-1 and Ezh2 protein level is reduced by treatment with the dietary chemopreventive agents, sulforaphane and green tea polyphenol, and that this reduction involves ubiquitination of Bmi-1 and Ezh2, suggesting a key role of the proteasome.	Polyphenols	145-155	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	24-29
22595400-0	2012	Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer.	Polyphenols	19-30	matrix metallopeptidase 9	Homo sapiens	72-77
22595400-0	2012	Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer.	Polyphenols	19-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22595400-8	2012	Our findings reveal that olive oil and red wine polyphenols reduce inflammatory angiogenesis in cultured endothelial cells, through MMP-9 and COX-2 inhibition, supporting a potential protective role for dietary polyphenols in atherosclerotic vascular disease and cancer.	Polyphenols	48-59	matrix metallopeptidase 9	Homo sapiens	132-137
22595400-8	2012	Our findings reveal that olive oil and red wine polyphenols reduce inflammatory angiogenesis in cultured endothelial cells, through MMP-9 and COX-2 inhibition, supporting a potential protective role for dietary polyphenols in atherosclerotic vascular disease and cancer.	Polyphenols	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
22987139-1	2012	The interaction between the natural polyphenol resveratrol and human serum albumin (HSA), the most abundant transport protein in plasma, has been studied in the absence and in the presence of up to six molecules of stearic acids (SA) pre-complexed with the protein.	Polyphenols	36-46	albumin	Homo sapiens	69-82
23181222-6	2012	Several bioactive molecules such as dietary polyphenols, aspirin and its hydrolysis product salicylate, are known to stimulate PON1 transcription activation in mouse liver and HepG2 cell line.	Polyphenols	44-55	paraoxonase 1	Mus musculus	127-131
22964046-1	2012	This paper reports on the development and optimization of a modified Quick, Easy, Cheap Effective, Rugged and Safe (QuEChERS) based extraction technique coupled with a clean-up dispersive-solid phase extraction (dSPE) as a new, reliable and powerful strategy to enhance the extraction efficiency of free low molecular-weight polyphenols in selected species of dietary vegetables.	Polyphenols	325-336	Spatzle-Processing Enzyme	Drosophila melanogaster	212-216
23200064-0	2012	Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention.	Polyphenols	0-11	indoleamine 2,3-dioxygenase 1	Homo sapiens	20-49
23200064-17	2012	These results suggest that attenuation of immune suppression via inhibition of IDO-1 enzyme activity may be one of the important mechanisms of polyphenols in chemoprevention or combinatorial cancer therapy.	Polyphenols	143-154	indoleamine 2,3-dioxygenase 1	Homo sapiens	79-84
25538760-0	2012	Tea polyphenols increase X-ray repair cross-complementing protein 1 and apurinic/apyrimidinic endonuclease/redox factor-1 expression in the hippocampus of rats during cerebral ischemia/reperfusion injury.	Polyphenols	4-15	X-ray repair cross complementing 1	Rattus norvegicus	25-121
25538760-5	2012	We demonstrated that intraperitoneal injection of tea polyphenols immediately after reperfusion significantly reduced apoptosis in the hippocampal CA1 region; this effect started 6 hours following reperfusion.	Polyphenols	54-65	carbonic anhydrase 1	Rattus norvegicus	147-150
25538760-6	2012	Immunohistochemical staining showed that tea polyphenols could reverse the ischemia/reperfusion-induced reduction in the expression of DNA repair proteins, X-ray repair cross-complementing protein 1 and apurinic/apyrimidinic endonuclease/redox factor-1 starting at 2 hours.	Polyphenols	45-56	X-ray repair cross complementing 1	Rattus norvegicus	156-252
22932898-2	2012	We recently showed that Bmi-1 and Ezh2 protein level is reduced by treatment with the dietary chemopreventive agents, sulforaphane and green tea polyphenol, and that this reduction involves ubiquitination of Bmi-1 and Ezh2, suggesting a key role of the proteasome.	Polyphenols	145-155	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	34-38
22932898-2	2012	We recently showed that Bmi-1 and Ezh2 protein level is reduced by treatment with the dietary chemopreventive agents, sulforaphane and green tea polyphenol, and that this reduction involves ubiquitination of Bmi-1 and Ezh2, suggesting a key role of the proteasome.	Polyphenols	145-155	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	208-213
22932898-2	2012	We recently showed that Bmi-1 and Ezh2 protein level is reduced by treatment with the dietary chemopreventive agents, sulforaphane and green tea polyphenol, and that this reduction involves ubiquitination of Bmi-1 and Ezh2, suggesting a key role of the proteasome.	Polyphenols	145-155	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	218-222
22820246-6	2012	(iv) Regulatory circuits may also have evolved between dietary polyphenols, which are efficient substrates of UGTs and activators of the Ah receptor.	Polyphenols	63-74	aryl hydrocarbon receptor	Homo sapiens	137-148
22647426-6	2012	RESULTS: OSA of fruit beverages and of reagent polyphenols were markedly increased by whole saliva, mucin and by red blood cells.	Polyphenols	47-58	LOC100508689	Homo sapiens	100-105
22909341-2	2012	The naturally occurring polyphenol resveratrol is associated with anti-proliferative and anti-inflammatory properties via mechanisms implicating inhibition of STAT3 signaling.	Polyphenols	24-34	signal transducer and activator of transcription 3	Homo sapiens	159-164
22647426-3	2012	We hypothesized that whole saliva, proteins such as albumin and mucin, human red blood cells and platelets, may all increase the "solubility" and availability of lipophilic antioxidant polyphenols thus increasing the OSA of whole saliva.	Polyphenols	185-196	LOC100508689	Homo sapiens	64-69
22867086-1	2012	Several polyphenols have been shown to activate the aryl hydrocarbon receptor (AHR) in spite of the fact that they bind to the receptor with low affinity.	Polyphenols	8-19	aryl hydrocarbon receptor	Homo sapiens	52-77
22871396-8	2012	Further analysis indicated that the inhibition of migration by grape skin polyphenols is involved in blocking the PI3k/Akt and MAPK pathways.	Polyphenols	74-85	thymoma viral proto-oncogene 1	Mus musculus	119-122
22190076-0	2012	Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model.	Polyphenols	23-33	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	43-47
22884420-0	2012	Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG.	Polyphenols	115-125	ribosomal protein SA	Homo sapiens	34-57
22867086-3	2012	Using recombinant human enzyme, we confirmed earlier reported inhibitory effects of the polyphenols on cytochrome P4501A1 (CYP1A1) activity, and inhibition of metabolic clearance of FICZ was documented in FICZ-treated immortalized human keratinocytes (HaCaT).	Polyphenols	88-99	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	103-121
22867086-1	2012	Several polyphenols have been shown to activate the aryl hydrocarbon receptor (AHR) in spite of the fact that they bind to the receptor with low affinity.	Polyphenols	8-19	aryl hydrocarbon receptor	Homo sapiens	79-82
22867086-3	2012	Using recombinant human enzyme, we confirmed earlier reported inhibitory effects of the polyphenols on cytochrome P4501A1 (CYP1A1) activity, and inhibition of metabolic clearance of FICZ was documented in FICZ-treated immortalized human keratinocytes (HaCaT).	Polyphenols	88-99	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129
22867086-6	2012	To test the ability of the polyphenols to activate the AHR in the absence of FICZ, the cells were treated in medium, which in contrast to commercial batches of medium did not contain background levels of FICZ.	Polyphenols	27-38	aryl hydrocarbon receptor	Homo sapiens	55-58
23074906-1	2012	The results obtained from our previous study showed that the addition of a lychee fruit-derived low molecular form of polyphenol, Oligonol, provoked higher levels of lipolytic activity via the degradation of perilipin 1 in primary rat adipocytes.	Polyphenols	118-128	perilipin 1	Rattus norvegicus	208-219
22416799-5	2012	In 3T3-L1 adipocytes, treatment with green tea and its major polyphenol, (-)-epigallocatechin gallate, induced the expression of IGFBP-1 in a dose-dependent manner by Western blot.	Polyphenols	61-71	insulin-like growth factor binding protein 1	Mus musculus	129-136
22771471-0	2012	Enhanced antioxidant effect of prenylated polyphenols as Fyn inhibitor.	Polyphenols	42-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	57-60
22771471-11	2012	In conclusion, kazinols as multi-prenylated polyphenols possess increased antioxidant and cytoprotective activity, which depends on the activation of LKB1-AMPK pathway downstream of Fyn inhibition.	Polyphenols	44-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	182-185
22658952-10	2012	Our data also show that spermidine, a polyamine thought to reduce oxidative stress and to prolong survival, and EGCG, a green tea polyphenol, inhibit hGDH2 at lower concentrations than hGDH1.	Polyphenols	130-140	glutamate dehydrogenase 2	Homo sapiens	150-155
22744336-3	2012	In human tumors, honokiol (a polyphenol in herbal teas) has growth-inhibitory and proapoptotic effects associated with suppressed activation of STAT3.	Polyphenols	29-39	signal transducer and activator of transcription 3	Homo sapiens	144-149
22522122-0	2012	Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway.	Polyphenols	13-24	interleukin 6	Homo sapiens	64-77
23497651-4	2012	HDL capacity to bind with PON1 is possible under specific experimental conditions, such as oxidation, addition of polyphenols, or in diabetic patients with polyphenols doses.	Polyphenols	114-125	paraoxonase 1	Homo sapiens	26-30
23497651-4	2012	HDL capacity to bind with PON1 is possible under specific experimental conditions, such as oxidation, addition of polyphenols, or in diabetic patients with polyphenols doses.	Polyphenols	156-167	paraoxonase 1	Homo sapiens	26-30
22522122-0	2012	Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway.	Polyphenols	13-24	signal transducer and activator of transcription 3	Homo sapiens	78-83
22522122-4	2012	The objectives of the current study are to investigate the inhibitory effects of these polyphenols on angiogenesis triggered by an inflammatory cytokine (IL-6) and to determine the mechanisms underlying this action.	Polyphenols	87-98	interleukin 6	Homo sapiens	154-158
22522122-5	2012	We found that, among the tested polyphenols, apigenin and luteolin were the most potent angiogenesis inhibitors through their inhibitory effect on the inflammatory cytokine IL-6/STAT3 pathway.	Polyphenols	32-43	interleukin 6	Homo sapiens	173-177
22522122-7	2012	Interestingly, these polyphenols also modulated the expression of IL-6 signal transducing receptor (IL-6Ralpha) and the secretion of the extracellular matrix degrading enzyme MMP-2 as well as the expression of suppressor of cytokine signaling (SOCS3) protein.	Polyphenols	21-32	interleukin 6	Homo sapiens	66-70
22522122-7	2012	Interestingly, these polyphenols also modulated the expression of IL-6 signal transducing receptor (IL-6Ralpha) and the secretion of the extracellular matrix degrading enzyme MMP-2 as well as the expression of suppressor of cytokine signaling (SOCS3) protein.	Polyphenols	21-32	interleukin 6 receptor	Homo sapiens	100-110
22522122-7	2012	Interestingly, these polyphenols also modulated the expression of IL-6 signal transducing receptor (IL-6Ralpha) and the secretion of the extracellular matrix degrading enzyme MMP-2 as well as the expression of suppressor of cytokine signaling (SOCS3) protein.	Polyphenols	21-32	matrix metallopeptidase 2	Homo sapiens	175-180
22522122-7	2012	Interestingly, these polyphenols also modulated the expression of IL-6 signal transducing receptor (IL-6Ralpha) and the secretion of the extracellular matrix degrading enzyme MMP-2 as well as the expression of suppressor of cytokine signaling (SOCS3) protein.	Polyphenols	21-32	cytokine inducible SH2 containing protein	Homo sapiens	210-242
22522122-7	2012	Interestingly, these polyphenols also modulated the expression of IL-6 signal transducing receptor (IL-6Ralpha) and the secretion of the extracellular matrix degrading enzyme MMP-2 as well as the expression of suppressor of cytokine signaling (SOCS3) protein.	Polyphenols	21-32	suppressor of cytokine signaling 3	Homo sapiens	244-249
22860586-2	2012	Most studies on the mechanisms underlying these beneficial effects, among which the suppression of tissue factor (TF) synthesis in blood mononuclear cells (MNC) and vascular endothelium is a prominent one, have been performed with purified polyphenols, while little is known about the effect of fresh grapes which contain a multitude of phytochemicals whose interaction may lead to different cell responses.	Polyphenols	240-251	coagulation factor III, tissue factor	Homo sapiens	99-112
22715906-0	2012	Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling: possible involvement of Hsp90, Wnt/beta-catenin signaling and FOXO1.	Polyphenols	10-21	AKT serine/threonine kinase 1	Homo sapiens	76-79
22715906-0	2012	Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling: possible involvement of Hsp90, Wnt/beta-catenin signaling and FOXO1.	Polyphenols	10-21	catenin beta 1	Homo sapiens	126-138
22860586-7	2012	When selected purified polyphenols were tested, their ability to inhibit TF expression was markedly lower as compared to grape extracts, whereas a mixture of some representative polyphenols was much more efficient, supporting the occurrence of a synergistic effect.	Polyphenols	23-34	coagulation factor III, tissue factor	Homo sapiens	73-75
22860586-2	2012	Most studies on the mechanisms underlying these beneficial effects, among which the suppression of tissue factor (TF) synthesis in blood mononuclear cells (MNC) and vascular endothelium is a prominent one, have been performed with purified polyphenols, while little is known about the effect of fresh grapes which contain a multitude of phytochemicals whose interaction may lead to different cell responses.	Polyphenols	240-251	coagulation factor III, tissue factor	Homo sapiens	114-116
22676643-0	2012	Mulberry leaf polyphenol extract induced apoptosis involving regulation of adenosine monophosphate-activated protein kinase/fatty acid synthase in a p53-negative hepatocellular carcinoma cell.	Polyphenols	14-24	fatty acid synthase	Homo sapiens	124-143
22676643-0	2012	Mulberry leaf polyphenol extract induced apoptosis involving regulation of adenosine monophosphate-activated protein kinase/fatty acid synthase in a p53-negative hepatocellular carcinoma cell.	Polyphenols	14-24	tumor protein p53	Homo sapiens	149-152
22676643-3	2012	In this study, we aimed to detect the effect of the mulberry leaf polyphenol extract (MLPE) on inducing cell death in p53-negative (Hep3B) and p53-positive (Hep3B with transfected p53) hepatocellular carcinoma cells and also to clarify the role of p53 in MLPE-treated cells.	Polyphenols	66-76	tumor protein p53	Homo sapiens	118-121
22676643-3	2012	In this study, we aimed to detect the effect of the mulberry leaf polyphenol extract (MLPE) on inducing cell death in p53-negative (Hep3B) and p53-positive (Hep3B with transfected p53) hepatocellular carcinoma cells and also to clarify the role of p53 in MLPE-treated cells.	Polyphenols	66-76	tumor protein p53	Homo sapiens	143-146
22676643-3	2012	In this study, we aimed to detect the effect of the mulberry leaf polyphenol extract (MLPE) on inducing cell death in p53-negative (Hep3B) and p53-positive (Hep3B with transfected p53) hepatocellular carcinoma cells and also to clarify the role of p53 in MLPE-treated cells.	Polyphenols	66-76	tumor protein p53	Homo sapiens	143-146
22676643-3	2012	In this study, we aimed to detect the effect of the mulberry leaf polyphenol extract (MLPE) on inducing cell death in p53-negative (Hep3B) and p53-positive (Hep3B with transfected p53) hepatocellular carcinoma cells and also to clarify the role of p53 in MLPE-treated cells.	Polyphenols	66-76	tumor protein p53	Homo sapiens	143-146
22753716-8	2012	Our studies in vitro demonstrated that FAS might also be a molecular target for the antiproliferative activity of olive oil polyphenols in a metabolically defined subset of patients with colon cancer.	Polyphenols	124-135	fatty acid synthase	Homo sapiens	39-42
22086824-2	2012	Based on our previous data indicating that administration of a polyphenol-rich (PrB) blueberry extract (from wild Vaccinium angustifolium) is memory enhancing in healthy mice and in order to delineate the neuroprotective mechanisms, this study investigated the antioxidant effects of PrB in H2O2-induced oxidative damage, Abeta peptide fibrillogenesis and APP metabolism.	Polyphenols	63-73	RB transcriptional corepressor 1	Homo sapiens	80-83
22503922-0	2012	Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice.	Polyphenols	14-25	microRNA 122	Mus musculus	80-87
22503922-6	2012	The addition of polyphenols also resulted in changes in the expression of miR-103, miR-107 and miR-122.	Polyphenols	16-27	microRNA 107	Mus musculus	83-90
22503922-6	2012	The addition of polyphenols also resulted in changes in the expression of miR-103, miR-107 and miR-122.	Polyphenols	16-27	microRNA 122	Mus musculus	95-102
22552582-0	2012	Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases.	Polyphenols	10-21	tumor protein p53	Homo sapiens	31-34
22552582-3	2012	In this study, we demonstrate that green tea polyphenols (GTPs) and their major constituent, (-) epigallocatechin-3-gallate (EGCG), activate p53 through acetylation at the Lys373 and Lys382 residues by inhibiting class I HDACs in LNCaP human prostate cancer cells.	Polyphenols	45-56	tumor protein p53	Homo sapiens	141-144
21196065-9	2012	The GSPE mechanism may include a noncovalent interaction of polyphenols with proline residues in the proline-rich domain of tau, with Pin1 sites at P213 and P232 most seriously affected as judged by suppression of labeling.	Polyphenols	60-71	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	134-138
22349733-1	2012	Phenylalanine ammonia lyase (PAL) is the first entry enzyme of the phenylpropanoid pathway producing phenolics, widespread constituents of plant foods and beverages, including chlorogenic acids, polyphenols found at remarkably high levels in the coffee bean and long recognized as powerful antioxidants.	Polyphenols	195-206	phenylalanine ammonia-lyase	Solanum lycopersicum	29-32
22749181-7	2012	Green tea polyphenol supplementation increased percentage of fat-free mass, bone mineral density and strength, and GPX protein expression and decreased percentage of fat mass, serum insulin-like growth factor I, leptin, adiponectin, and proinflammatory cytokines in the obese rats.	Polyphenols	10-20	insulin-like growth factor 1	Rattus norvegicus	182-210
22743590-3	2012	In primary screening this semisynthetic halogenated polyphenol was identified to inhibit the activities of kinases ZAP-70 and Lck (IC50 0.34 microM and 16 microM, respectively), as well as hydrolase DPPIV (at 80 microM 41% inhibition).	Polyphenols	52-62	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	115-121
22743590-3	2012	In primary screening this semisynthetic halogenated polyphenol was identified to inhibit the activities of kinases ZAP-70 and Lck (IC50 0.34 microM and 16 microM, respectively), as well as hydrolase DPPIV (at 80 microM 41% inhibition).	Polyphenols	52-62	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	126-129
22743590-3	2012	In primary screening this semisynthetic halogenated polyphenol was identified to inhibit the activities of kinases ZAP-70 and Lck (IC50 0.34 microM and 16 microM, respectively), as well as hydrolase DPPIV (at 80 microM 41% inhibition).	Polyphenols	52-62	dipeptidyl peptidase 4	Homo sapiens	199-204
22620965-0	2012	Natural polyphenols as modulators of TTR amyloidogenesis: in vitro and in vivo evidences towards therapy.	Polyphenols	8-19	transthyretin	Mus musculus	37-40
22620965-1	2012	Several natural polyphenols have been reported to act on different amyloidogenic proteins inhibiting amyloid formation therefore we decided to test their effect on transthyretin (TTR) amyloid formation.	Polyphenols	16-27	transthyretin	Mus musculus	164-177
22620965-1	2012	Several natural polyphenols have been reported to act on different amyloidogenic proteins inhibiting amyloid formation therefore we decided to test their effect on transthyretin (TTR) amyloid formation.	Polyphenols	16-27	transthyretin	Mus musculus	179-182
29243592-5	2012	In four solvent fractions separated from ECK-E, hypnotic activity was proportional to contents of total phenols and total phlorotannins, known as seaweed polyphenols.	Polyphenols	154-165	Eph receptor A2	Mus musculus	41-46
22749181-7	2012	Green tea polyphenol supplementation increased percentage of fat-free mass, bone mineral density and strength, and GPX protein expression and decreased percentage of fat mass, serum insulin-like growth factor I, leptin, adiponectin, and proinflammatory cytokines in the obese rats.	Polyphenols	10-20	leptin	Rattus norvegicus	212-218
22749181-7	2012	Green tea polyphenol supplementation increased percentage of fat-free mass, bone mineral density and strength, and GPX protein expression and decreased percentage of fat mass, serum insulin-like growth factor I, leptin, adiponectin, and proinflammatory cytokines in the obese rats.	Polyphenols	10-20	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	220-231
22654783-1	2012	Resveratrol is a naturally occurring polyphenol that activates SIRT1, an NAD-dependent deacetylase.	Polyphenols	37-47	sirtuin 1	Mus musculus	63-68
22386654-9	2012	The expression of TNFalpha was reduced by both polyphenols in a dose-dependent manner, but more efficiently by Tyrosol.	Polyphenols	47-58	tumor necrosis factor	Homo sapiens	18-26
29025473-0	2012	Dietary polyphenols affect MUC5AC expression and ciliary movement in respiratory cells and nasal mucosa.	Polyphenols	8-19	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	27-33
22425031-0	2012	Structure-activity relationship of selected polyphenol derivatives as inhibitors of Bax/Bcl-xL interaction.	Polyphenols	44-54	BCL2 associated X, apoptosis regulator	Homo sapiens	84-87
22425031-0	2012	Structure-activity relationship of selected polyphenol derivatives as inhibitors of Bax/Bcl-xL interaction.	Polyphenols	44-54	BCL2 like 1	Homo sapiens	88-94
22425031-1	2012	This paper describes the synthesis of nine selected diaryl/heteroaryl-containing phenol and polyphenol derivatives which have been evaluated against Bax/Bcl-xL interaction in comparison with ABT-737.	Polyphenols	92-102	BCL2 associated X, apoptosis regulator	Homo sapiens	149-152
22425031-1	2012	This paper describes the synthesis of nine selected diaryl/heteroaryl-containing phenol and polyphenol derivatives which have been evaluated against Bax/Bcl-xL interaction in comparison with ABT-737.	Polyphenols	92-102	BCL2 like 1	Homo sapiens	153-159
22425031-3	2012	These preliminary results demonstrate that such polyphenol-derived molecules are attractive compounds regarding anticancer activity and that the phenol at position 3 is important regarding disruption of Bax/Bcl-xL interaction.	Polyphenols	48-58	BCL2 like 1	Homo sapiens	207-213
22178470-4	2012	The role of dietary polyphenols in regulation of SIRT1 in inflammaging is also discussed.	Polyphenols	20-31	sirtuin 1	Homo sapiens	49-54
22178470-8	2012	Polyphenols and its analogs have been shown to activate SIRT1 although they have anti-inflammatory and antioxidant properties.	Polyphenols	0-11	sirtuin 1	Homo sapiens	56-61
22493606-6	2012	DAF-12, which integrates TGF-beta and Insulin-like downstream signaling, and genetic players of the p38 MAPK pathway therefore seem to be crucial regulators for both polyphenols.	Polyphenols	166-177	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	0-6
22257159-0	2012	Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cdelta and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells.	Polyphenols	10-20	protein kinase C, delta	Mus musculus	95-116
22257159-0	2012	Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cdelta and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells.	Polyphenols	10-20	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	121-142
22388319-11	2012	Multiple mechanisms may contribute to the beneficial effects of the polyphenols, including a reduction in myocardial oxidative stress and related protein modifications, amelioration of insulin resistance, and increased plasma adiponectin.	Polyphenols	68-79	adiponectin, C1Q and collagen domain containing	Mus musculus	226-237
22381400-3	2012	We further studied the involvement of neuroprotective pathway protein AKT in green tea polyphenols protection against iAbeta-induced cytotoxicity on cultured rat primary prefrontal cortical neurons.	Polyphenols	87-98	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
22381400-4	2012	The results demonstrated that the content of p-AKT decreased significantly after iAbeta treatment, while administration of green tea polyphenols significantly inhibited the iAbeta-induced decrease in the content of p-AKT.	Polyphenols	133-144	AKT serine/threonine kinase 1	Rattus norvegicus	217-220
22381400-5	2012	Moreover, blockade of AKT signalling inhibited the protective effects of green tea polyphenols against iAbeta-induced neurotoxicity.	Polyphenols	83-94	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
22381400-6	2012	The results suggest that green tea polyphenols may play a protective effect on cultured rat primary prefrontal cortical neurons against iAbeta-induced cytotoxicity and AKT is involved in the green tea polyphenols-induced protective effects.	Polyphenols	201-212	AKT serine/threonine kinase 1	Rattus norvegicus	168-171
22613332-0	2012	[Effects of tea polyphenols on the expression of NF-kappaB, COX-2 and survivin in Lewis lung carcinoma xenografts in C57BL/6 mice].	Polyphenols	16-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
22613332-0	2012	[Effects of tea polyphenols on the expression of NF-kappaB, COX-2 and survivin in Lewis lung carcinoma xenografts in C57BL/6 mice].	Polyphenols	16-27	prostaglandin-endoperoxide synthase 2	Mus musculus	60-65
22613332-0	2012	[Effects of tea polyphenols on the expression of NF-kappaB, COX-2 and survivin in Lewis lung carcinoma xenografts in C57BL/6 mice].	Polyphenols	16-27	baculoviral IAP repeat-containing 5	Mus musculus	70-78
22613332-2	2012	The anti-angiogenic effect of tea polyphenols (TPs) on lung carcinoma was confirmed in our previous study.	Polyphenols	34-45	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	30-33
22257159-0	2012	Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cdelta and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells.	Polyphenols	10-20	ribosomal protein SA	Mus musculus	153-176
22442749-10	2012	Plant-derived polyphenols and flavonoids are identified as natural inhibitors of mTORC1 and exert anti-diabetic and anti-obesity effects.	Polyphenols	14-25	CREB regulated transcription coactivator 1	Mus musculus	81-87
22079166-9	2012	The atomic structure of the ECG-GDH complex and mutagenesis studies is directing structure-based drug design using these polyphenols as a base scaffold.	Polyphenols	121-132	glutamate dehydrogenase 1	Homo sapiens	32-35
22050122-0	2012	The effect of green tea polyphenols on macrophage migration inhibitory factor-associated steroid resistance.	Polyphenols	24-35	macrophage migration inhibitory factor	Homo sapiens	39-77
22279137-0	2012	Suppression of hypoxia-inducible factor-1alpha contributes to the antiangiogenic activity of red propolis polyphenols in human endothelial cells.	Polyphenols	106-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-46
22245592-0	2012	Involvement of SIRT1 in hypoxic down-regulation of c-Myc and beta-catenin and hypoxic preconditioning effect of polyphenols.	Polyphenols	112-123	sirtuin 1	Homo sapiens	15-20
22322600-10	2012	Our findings demonstrate, for the first time, that TA inhibits AT1R gene expression and cellular response, suggesting the observed protective effects of dietary polyphenols on cardiovascular conditions may be, in part, through inhibition of AT1R expression.	Polyphenols	161-172	angiotensin II receptor, type 1a	Rattus norvegicus	63-67
22322600-10	2012	Our findings demonstrate, for the first time, that TA inhibits AT1R gene expression and cellular response, suggesting the observed protective effects of dietary polyphenols on cardiovascular conditions may be, in part, through inhibition of AT1R expression.	Polyphenols	161-172	angiotensin II receptor, type 1a	Rattus norvegicus	241-245
24471056-7	2012	Taken together, these results suggest that polyphenols of Ecklonia cava (SPN) and dieckol reduce body weight gain and fat accumulation in HFD-induced obese mice, and that their hypolipidemic effect is related to the inhibition of adipogenesis of adipocytes and HMGCoA reductase activity.	Polyphenols	43-54	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	261-277
21967610-0	2012	Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor system.	Polyphenols	6-17	epidermal growth factor receptor	Homo sapiens	152-184
22252293-0	2012	Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-kappaB, p38MAPK and Akt inhibition.	Polyphenols	37-48	GLI family zinc finger 2	Homo sapiens	92-97
22252293-0	2012	Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-kappaB, p38MAPK and Akt inhibition.	Polyphenols	37-48	nuclear factor kappa B subunit 1	Homo sapiens	126-135
22252293-0	2012	Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-kappaB, p38MAPK and Akt inhibition.	Polyphenols	37-48	AKT serine/threonine kinase 1	Homo sapiens	149-152
22252293-6	2012	We further demonstrated that the unexpected increase in IL-6 secretion that occurred when quince polyphenols were associated with LPS treatment was partially responsible for the polyphenols-mediated inhibition of TNF-alpha secretion.	Polyphenols	97-108	tumor necrosis factor	Homo sapiens	213-222
22252293-6	2012	We further demonstrated that the unexpected increase in IL-6 secretion that occurred when quince polyphenols were associated with LPS treatment was partially responsible for the polyphenols-mediated inhibition of TNF-alpha secretion.	Polyphenols	178-189	tumor necrosis factor	Homo sapiens	213-222
22252293-7	2012	Biochemical analysis showed that quince polyphenols extract inhibited the LPS-mediated activation of three major cellular pro-inflammatory effectors, nuclear factor-kappa B (NF-kappaB), p38MAPK and Akt.	Polyphenols	40-51	nuclear factor kappa B subunit 1	Homo sapiens	174-183
22252293-7	2012	Biochemical analysis showed that quince polyphenols extract inhibited the LPS-mediated activation of three major cellular pro-inflammatory effectors, nuclear factor-kappa B (NF-kappaB), p38MAPK and Akt.	Polyphenols	40-51	AKT serine/threonine kinase 1	Homo sapiens	198-201
22074503-8	2012	Plant extracts clearly demonstrated effective AChE inhibitory activity (480 +- 98 and 490 +- 46 mug mL-1, respectively), that could be associated to polyphenols.	Polyphenols	149-160	L1 cell adhesion molecule	Mus musculus	100-104
22153697-2	2012	The present study was conducted to investigate the effects of grape polyphenols on LDLR gene expression in human hepatocyte models.	Polyphenols	68-79	low density lipoprotein receptor	Homo sapiens	83-87
22159297-0	2012	Lentil polyphenol extract prevents angiotensin II-induced hypertension, vascular remodelling and perivascular fibrosis.	Polyphenols	7-17	angiotensinogen	Rattus norvegicus	35-49
21419610-7	2012	Curcumin suppressed retinoic acid stimulated expression of ADAMTS-5, and both polyphenols suppressed basal expression of ADAMTS-5.	Polyphenols	78-89	ADAM metallopeptidase with thrombospondin type 1 motif 5	Bos taurus	121-129
21736590-3	2012	Infestation-dependent decreases in the abundance of key transcripts such as chloroplastic FeSOD, peroxisomal catalase 2, PR1 and JAZ1 preceded detectable leaf H(2)O(2) or polyphenol accumulation.	Polyphenols	171-181	catalase isozyme 1	Solanum tuberosum	109-119
23221717-4	2012	Polyphenols, including catechins, curcumin, resveratrol, silibinin, and sulfurous compound alpha-lipoic acid, were found to inhibit both HOCl- and human MPO-induced Cl-Guo formation dose-dependently.	Polyphenols	0-11	myeloperoxidase	Homo sapiens	153-156
22107329-4	2012	In this study, we investigated the binding modes of EGCG to HDC and DDC as a first step for designing new polyphenol-based HDC/DDC-specific inhibitors.	Polyphenols	106-116	histidine decarboxylase	Homo sapiens	60-63
22107329-4	2012	In this study, we investigated the binding modes of EGCG to HDC and DDC as a first step for designing new polyphenol-based HDC/DDC-specific inhibitors.	Polyphenols	106-116	dopa decarboxylase	Homo sapiens	68-71
22107329-4	2012	In this study, we investigated the binding modes of EGCG to HDC and DDC as a first step for designing new polyphenol-based HDC/DDC-specific inhibitors.	Polyphenols	106-116	histidine decarboxylase	Homo sapiens	123-126
22107329-4	2012	In this study, we investigated the binding modes of EGCG to HDC and DDC as a first step for designing new polyphenol-based HDC/DDC-specific inhibitors.	Polyphenols	106-116	dopa decarboxylase	Homo sapiens	127-130
22109835-0	2012	SNARE-wedging polyphenols as small molecular botox.	Polyphenols	14-25	small NF90 (ILF3) associated RNA E	Homo sapiens	0-5
22109835-3	2012	Recently, we have shown that several polyphenols inhibit neurotransmitter release from neuronal PC12 cells by interfering with SNARE complex formation.	Polyphenols	37-48	small NF90 (ILF3) associated RNA E	Homo sapiens	127-132
22101284-6	2012	Moreover, the reduction of intercellular adhesion molecule-1 (ICAM-1) expression in Caco-2 cells can be considered directly correlated to the mucosal anti-inflammatory effect induced by the hydrocortisone and natural polyphenols.	Polyphenols	217-228	intercellular adhesion molecule 1	Homo sapiens	27-60
22101284-6	2012	Moreover, the reduction of intercellular adhesion molecule-1 (ICAM-1) expression in Caco-2 cells can be considered directly correlated to the mucosal anti-inflammatory effect induced by the hydrocortisone and natural polyphenols.	Polyphenols	217-228	intercellular adhesion molecule 1	Homo sapiens	62-68
22950347-7	2012	Polyphenols activate and enhance endothelial nitric oxide synthase (eNOS) expression by several signaling pathways, increase glutathione (GSH), and inhibit ROS-producing enzymes such as NADPH and xanthine oxidases.	Polyphenols	0-11	nitric oxide synthase 3	Homo sapiens	33-66
23098466-4	2012	RESULTS: The results showed that tea polyphenols: (1) inhibited the expression of CD44 and CD54, two important adhesion molecules in the PG cells in a dose-dependent manner; (2) significantly blocked the adhesion of PG cells to EC cells not only in a state of rest but also when active; and (3) influenced CD44 and CD54 expression during the adhesion process of PG cells to EC cells.	Polyphenols	37-48	CD44 molecule (Indian blood group)	Homo sapiens	82-86
23098466-4	2012	RESULTS: The results showed that tea polyphenols: (1) inhibited the expression of CD44 and CD54, two important adhesion molecules in the PG cells in a dose-dependent manner; (2) significantly blocked the adhesion of PG cells to EC cells not only in a state of rest but also when active; and (3) influenced CD44 and CD54 expression during the adhesion process of PG cells to EC cells.	Polyphenols	37-48	intercellular adhesion molecule 1	Homo sapiens	91-95
23098466-4	2012	RESULTS: The results showed that tea polyphenols: (1) inhibited the expression of CD44 and CD54, two important adhesion molecules in the PG cells in a dose-dependent manner; (2) significantly blocked the adhesion of PG cells to EC cells not only in a state of rest but also when active; and (3) influenced CD44 and CD54 expression during the adhesion process of PG cells to EC cells.	Polyphenols	37-48	CD44 molecule (Indian blood group)	Homo sapiens	306-310
23098466-4	2012	RESULTS: The results showed that tea polyphenols: (1) inhibited the expression of CD44 and CD54, two important adhesion molecules in the PG cells in a dose-dependent manner; (2) significantly blocked the adhesion of PG cells to EC cells not only in a state of rest but also when active; and (3) influenced CD44 and CD54 expression during the adhesion process of PG cells to EC cells.	Polyphenols	37-48	intercellular adhesion molecule 1	Homo sapiens	315-319
23098466-5	2012	CONCLUSION: The data indicated that the blocking role of tea polyphenols in the adhesion of PG cells to EC cells is related to CD44 and CD54.	Polyphenols	61-72	CD44 molecule (Indian blood group)	Homo sapiens	127-131
23098466-5	2012	CONCLUSION: The data indicated that the blocking role of tea polyphenols in the adhesion of PG cells to EC cells is related to CD44 and CD54.	Polyphenols	61-72	intercellular adhesion molecule 1	Homo sapiens	136-140
22523472-4	2012	In this study, we evaluated the pharmacological targeting of Sirt1 by the diet-derived and antiinflammatory polyphenol resveratrol.	Polyphenols	108-118	sirtuin 1	Homo sapiens	61-66
22716122-0	2012	Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing.	Polyphenols	40-51	furin, paired basic amino acid cleaving enzyme	Homo sapiens	55-60
22716122-2	2012	This prompted investigations to identify PC inhibiting polyphenols that could affect IGF-1R-mediated tumorigenesis since pro-IGF-1R is bioactivated by PCs like furin.	Polyphenols	55-66	insulin like growth factor 1 receptor	Homo sapiens	85-91
22716122-2	2012	This prompted investigations to identify PC inhibiting polyphenols that could affect IGF-1R-mediated tumorigenesis since pro-IGF-1R is bioactivated by PCs like furin.	Polyphenols	55-66	insulin like growth factor 1 receptor	Homo sapiens	125-131
22716122-2	2012	This prompted investigations to identify PC inhibiting polyphenols that could affect IGF-1R-mediated tumorigenesis since pro-IGF-1R is bioactivated by PCs like furin.	Polyphenols	55-66	furin, paired basic amino acid cleaving enzyme	Homo sapiens	160-165
22716122-3	2012	Initial screening of polyphenols for their impact on in vitro cleavage of fluorogenic peptide substrate Pyr-RTKR-AMC by human furin (hfurin(573)) indeed revealed varying inhibitory effects.	Polyphenols	21-32	furin, paired basic amino acid cleaving enzyme	Homo sapiens	126-131
21807089-10	2012	The induction of immunosuppressive CD11b(+) Gr-1(+) cells by resveratrol during colitis is unique, and suggests an as-yet-unidentified mode of anti-inflammatory action of this plant polyphenol.	Polyphenols	182-192	integrin subunit alpha M	Homo sapiens	35-40
22202062-2	2012	Regulation of anti-tumor p53 functions by dietary plant polyphenols particularly black tea and its active component theaflavins has gained immense recognition from the point of view of both efficacy and safety.	Polyphenols	56-67	tumor protein p53	Homo sapiens	25-28
22611435-0	2012	Regulation of Proinflammatory Mediators via NF-kappaB and p38 MAPK-Dependent Mechanisms in RAW 264.7 Macrophages by Polyphenol Components Isolated from Korea Lonicera japonica THUNB.	Polyphenols	116-126	mitogen-activated protein kinase 14	Mus musculus	58-61
22611435-4	2012	Moreover, polyphenols inhibited nuclear translocation of NF-kappaB p65, phosphorylation/degradation of the inhibitor of kappaB, and phosphorylation of p38 MAPK, whereas the extracellular signal-regulated kinase and Janus N-terminal kinase were not affected.	Polyphenols	10-21	mitogen-activated protein kinase 14	Mus musculus	151-154
22611435-5	2012	These results indicate that polyphenol components isolated from Korea L. japonica T. should have anti-inflammatory effect on LPS-stimulated RAW 264.7 cells through the decrease of proinflammatory mediators expression by suppressing NF-kappaB and p38 MAPK activity.	Polyphenols	28-38	mitogen-activated protein kinase 14	Mus musculus	246-249
22754316-1	2012	The purpose of this study was to evaluate the antioxidant nature of tea polyphenol on S180 cells induced liver cancer in mice.	Polyphenols	72-82	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	68-71
22754316-3	2012	The antitumor activity of tea polyphenol has been determined in vivo in hepatocellular carcinoma mice after treatment of drug (50, 100, 150 mg/kg body weight) by gavage for 20 days.	Polyphenols	30-40	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	26-29
22754316-6	2012	These altered enzyme levels were ameliorated significantly by administration of tea polyphenol at the concentration of 50, 100, 150 mg/kg body weight in drug-treated animals.	Polyphenols	84-94	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	80-83
22754316-7	2012	These results indicate that the protective effect of tea polyphenol was associated with inhibition of MDA induced by S180 cells and to maintain the antioxidant enzyme levels.	Polyphenols	57-67	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	53-56
22186621-3	2012	Polyphenols in green tea, particularly epigallocatechin-3-gallate (EGCG), inhibit MMPs expression and activity.	Polyphenols	0-11	matrix metallopeptidase 2	Rattus norvegicus	82-86
21964320-7	2012	Green tea polyphenols also reduced serum corticosterone and ACTH levels in mice exposed to the FST.	Polyphenols	10-21	pro-opiomelanocortin-alpha	Mus musculus	60-64
23061908-0	2012	Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer.	Polyphenols	6-17	AKT serine/threonine kinase 1	Homo sapiens	26-29
23061908-0	2012	Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer.	Polyphenols	6-17	mechanistic target of rapamycin kinase	Homo sapiens	30-59
32092838-3	2012	Polyphenols in green tea, particularly epigallocatechin-3-gallate (EGCG), inhibit MMPs expression and activity.	Polyphenols	0-11	matrix metallopeptidase 2	Rattus norvegicus	82-86
23259067-9	2012	These results suggest that opposite effects of SIL on 1,25D-induced differentiation of HL60 and U937 cells may be determined by cell-type-specific signaling and transcriptional responses to this polyphenol resulting in differential modulation of RXRalpha expression.	Polyphenols	195-205	retinoid X receptor alpha	Homo sapiens	246-254
23285096-0	2012	Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms.	Polyphenols	10-21	tumor protein p53	Homo sapiens	29-32
23284772-9	2012	Both polyphenol and alkaloid fractions of areca nut were able to induce TGF-beta signaling and its downstream targets.	Polyphenols	5-15	transforming growth factor beta 1	Homo sapiens	72-80
23284772-11	2012	Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta.	Polyphenols	15-26	transforming growth factor beta 2	Homo sapiens	49-58
23284772-11	2012	Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta.	Polyphenols	15-26	thrombospondin 1	Homo sapiens	63-68
23284772-11	2012	Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta.	Polyphenols	15-26	transforming growth factor beta 1	Homo sapiens	49-57
23285096-0	2012	Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms.	Polyphenols	10-21	tumor protein p53	Homo sapiens	47-50
23284772-11	2012	Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta.	Polyphenols	15-26	transforming growth factor beta 1	Homo sapiens	90-98
23226522-6	2012	Our study shows a novel degradation path of beta-catenin protein in HeLa cells by Avenanthramide 2p (a polyphenol) and Triptolide (a diterpene triepoxide), respectively from oats and a Chinese medicinal plant.	Polyphenols	103-113	catenin beta 1	Homo sapiens	44-56
22253797-0	2012	Modulation of miRNA expression by dietary polyphenols in apoE deficient mice: a new mechanism of the action of polyphenols.	Polyphenols	111-122	apolipoprotein E	Mus musculus	57-61
22666419-0	2012	Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor.	Polyphenols	10-20	ribosomal protein SA	Homo sapiens	47-70
22347413-3	2012	Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3.	Polyphenols	19-30	insulin like growth factor 1	Homo sapiens	58-62
22347413-3	2012	Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3.	Polyphenols	19-30	insulin like growth factor binding protein 3	Homo sapiens	76-82
22540016-0	2012	The effect of enzymatically polymerised polyphenols on CD4 binding and cytokine production in murine splenocytes.	Polyphenols	40-51	CD4 antigen	Mus musculus	55-58
22540016-5	2012	Polymerised polyphenols induced several cytokines in murine splenocytes, with interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) being the most prominent.	Polyphenols	12-23	interferon gamma	Mus musculus	78-94
22540016-5	2012	Polymerised polyphenols induced several cytokines in murine splenocytes, with interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) being the most prominent.	Polyphenols	12-23	interferon gamma	Mus musculus	96-105
22540016-5	2012	Polymerised polyphenols induced several cytokines in murine splenocytes, with interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) being the most prominent.	Polyphenols	12-23	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	111-159
22540016-5	2012	Polymerised polyphenols induced several cytokines in murine splenocytes, with interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) being the most prominent.	Polyphenols	12-23	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	161-167
22540016-7	2012	Our results show that polymerised polyphenols increased IFN-gamma and GM-CSF production in splenocytes.	Polyphenols	34-45	interferon gamma	Mus musculus	56-65
22540016-7	2012	Our results show that polymerised polyphenols increased IFN-gamma and GM-CSF production in splenocytes.	Polyphenols	34-45	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	70-76
22540016-8	2012	In addition, the anti-CD4 neutralised monoclonal antibody (mAb) inhibited polymerised polyphenol-induced IFN-gamma and GM-CSF secretion.	Polyphenols	86-96	CD4 antigen	Mus musculus	22-25
22540016-8	2012	In addition, the anti-CD4 neutralised monoclonal antibody (mAb) inhibited polymerised polyphenol-induced IFN-gamma and GM-CSF secretion.	Polyphenols	86-96	interferon gamma	Mus musculus	105-114
22540016-8	2012	In addition, the anti-CD4 neutralised monoclonal antibody (mAb) inhibited polymerised polyphenol-induced IFN-gamma and GM-CSF secretion.	Polyphenols	86-96	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	119-125
22540016-9	2012	Moreover, polymerised polyphenols bound directly to a recombinant CD4 protein, and FACS analysis confirmed that interaction occurs between polymerised polyphenols and CD4 molecules expressed on the cell surface.	Polyphenols	22-33	CD4 antigen	Mus musculus	66-69
22540016-9	2012	Moreover, polymerised polyphenols bound directly to a recombinant CD4 protein, and FACS analysis confirmed that interaction occurs between polymerised polyphenols and CD4 molecules expressed on the cell surface.	Polyphenols	22-33	CD4 antigen	Mus musculus	167-170
22540016-9	2012	Moreover, polymerised polyphenols bound directly to a recombinant CD4 protein, and FACS analysis confirmed that interaction occurs between polymerised polyphenols and CD4 molecules expressed on the cell surface.	Polyphenols	151-162	CD4 antigen	Mus musculus	66-69
22540016-9	2012	Moreover, polymerised polyphenols bound directly to a recombinant CD4 protein, and FACS analysis confirmed that interaction occurs between polymerised polyphenols and CD4 molecules expressed on the cell surface.	Polyphenols	151-162	CD4 antigen	Mus musculus	167-170
22253797-0	2012	Modulation of miRNA expression by dietary polyphenols in apoE deficient mice: a new mechanism of the action of polyphenols.	Polyphenols	42-53	apolipoprotein E	Mus musculus	57-61
22253797-5	2012	The aim of this study was to investigate the impact of dietary supplementation with polyphenols at nutritional doses on miRNA expression in the livers of apolipoprotein E-deficient mice (apoE-/-) jointly with mRNA expression profiling.	Polyphenols	84-95	apolipoprotein E	Mus musculus	187-191
22253797-9	2012	We also observed that these polyphenols counteracted the modulation of miRNA expression induced by apoE mutation.	Polyphenols	28-39	apolipoprotein E	Mus musculus	99-103
22082235-3	2011	This study showed that epigallocatechin-3-gallate (EGCG), a natural polyphenol in green tea, is a potent inhibitor of MMP-2 expression.	Polyphenols	68-78	matrix metallopeptidase 2	Homo sapiens	118-123
22541285-5	2012	Epigallocatechin gallate, a green tea polyphenol, that modulates DYRK1A functioning has already shown preliminarily that this approach may prove useful in therapeutics.	Polyphenols	38-48	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	65-71
21196432-5	2011	Both strategies could use tyrosinase-mediated activation of quercetin, a dietary polyphenol that induces the expression of p53 and modulates reactive oxygen species.	Polyphenols	81-91	tyrosinase	Homo sapiens	26-36
22037513-2	2011	One important cellular pathway affected by polyphenols is the activation of the transcription factor Nrf2 via the electrophile response element, which mediates generation of phase 2 detoxifying enzymes.	Polyphenols	43-54	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
22037513-5	2011	Treatment of cells with either glutathione or metmyoglobin was found to decrease Nrf2 translocation and NQO1 activity induced by polyphenols by up to 40 and 60%, respectively.	Polyphenols	129-140	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
22037513-5	2011	Treatment of cells with either glutathione or metmyoglobin was found to decrease Nrf2 translocation and NQO1 activity induced by polyphenols by up to 40 and 60%, respectively.	Polyphenols	129-140	NAD(P)H quinone dehydrogenase 1	Homo sapiens	104-108
22037513-0	2011	Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones.	Polyphenols	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
21965273-0	2011	Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha.	Polyphenols	10-20	microRNA 210	Homo sapiens	82-89
21965273-0	2011	Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha.	Polyphenols	10-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
21196432-5	2011	Both strategies could use tyrosinase-mediated activation of quercetin, a dietary polyphenol that induces the expression of p53 and modulates reactive oxygen species.	Polyphenols	81-91	tumor protein p53	Homo sapiens	123-126
21810931-6	2011	This effect of the polyphenol was recapitulated in vitro, where RSV (10-80 muM) robustly inhibited iNOS protein induction and NO production in cytokine/LPS-treated L6 myocytes and 3T3-L1 adipocytes.	Polyphenols	19-29	nitric oxide synthase 2, inducible	Mus musculus	99-103
21452375-6	2011	Tea polyphenols also significantly decreased radiation-induced lipid peroxidation (malondialdehyde levels), elevated endogenous antioxidant enzymes (superoxide dismutase) and reduced the serum cytokines which were elevated in radiation-induced toxicity.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
21905751-6	2011	Additionally, the detection of urinary markers of gut microbial and phase II metabolism of nut polyphenols confirmed the understanding of their bioavailability and bioactivity as a priority area of research in the determination of the health effects derived from nut consumption.	Polyphenols	95-106	NUT midline carcinoma family member 1	Homo sapiens	91-94
21905751-6	2011	Additionally, the detection of urinary markers of gut microbial and phase II metabolism of nut polyphenols confirmed the understanding of their bioavailability and bioactivity as a priority area of research in the determination of the health effects derived from nut consumption.	Polyphenols	95-106	NUT midline carcinoma family member 1	Homo sapiens	263-266
21933112-4	2011	The strict regioselective patterns are highlighted for several SULT and UGT isoforms towards flavonoids, a large class of natural polyphenols.	Polyphenols	130-141	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	72-75
21787753-4	2011	Because IL-1 plays a crucial role in inflammation-associated carcinogenesis, we analyzed the biological effects of IL-1 and its modulation by the chemopreventive green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) in the human pancreatic adenocarcinoma cell line Colo357.	Polyphenols	172-182	interleukin 1 alpha	Homo sapiens	115-119
21733322-0	2011	Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors.	Polyphenols	96-106	C-C motif chemokine ligand 2	Homo sapiens	13-47
21733322-0	2011	Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors.	Polyphenols	96-106	macrophage migration inhibitory factor	Homo sapiens	52-90
21968503-13	2011	TGF-beta-inducible PAI-1 expression was attenuated by simvastatin and curcumin, a natural polyphenol.	Polyphenols	90-100	transforming growth factor beta 1	Homo sapiens	0-8
21968503-13	2011	TGF-beta-inducible PAI-1 expression was attenuated by simvastatin and curcumin, a natural polyphenol.	Polyphenols	90-100	serpin family E member 1	Homo sapiens	19-24
21742039-0	2011	Polyphenol rich botanicals used as food supplements interfere with EphA2-ephrinA1 system.	Polyphenols	0-10	EPH receptor A2	Homo sapiens	67-72
21742039-0	2011	Polyphenol rich botanicals used as food supplements interfere with EphA2-ephrinA1 system.	Polyphenols	0-10	ephrin A1	Homo sapiens	73-81
21970972-4	2011	Based on recent findings, one potential target for the antioxidant/antinflammatory properties of polyphenols is the heme oxygenase (HO)-1 pathway.	Polyphenols	97-108	heme oxygenase 1	Mus musculus	116-137
21936496-3	2011	Polyphenols identified in the date extract, such as chlorogenic acid, caffeic acid, pelargonin and ferulic acid, stimulated IFN-gamma mRNA expression significantly in mouse Peyer"s patch cell cultures.	Polyphenols	0-11	interferon gamma	Mus musculus	124-133
21936496-4	2011	Chlorogenic acid and caffeic acid also increased the number of IFN-gamma(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly.	Polyphenols	114-125	interferon gamma	Homo sapiens	150-159
21936496-4	2011	Chlorogenic acid and caffeic acid also increased the number of IFN-gamma(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly.	Polyphenols	114-125	integrin subunit alpha 2	Homo sapiens	162-167
21936496-4	2011	Chlorogenic acid and caffeic acid also increased the number of IFN-gamma(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly.	Polyphenols	114-125	integrin subunit alpha M	Homo sapiens	183-188
21499987-0	2011	Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders.	Polyphenols	39-50	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
22005428-6	2011	Compared with pre-study values, supplementation with citrus polyphenols resulted in lower plasma AGP and haptoglobin concentrations, while that with curcumin resulted in lower plasma AGP concentration.	Polyphenols	60-71	alpha-1-acid glycoprotein	Felis catus	97-100
22005428-6	2011	Compared with pre-study values, supplementation with citrus polyphenols resulted in lower plasma AGP and haptoglobin concentrations, while that with curcumin resulted in lower plasma AGP concentration.	Polyphenols	60-71	haptoglobin	Felis catus	105-116
21856773-8	2011	LMP1 oncogene, which is expressed in latency III phenotype, is involved with the higher resistance to the antiproliferative effect of resveratrol because siRNA-mediated inhibition of LMP1 greatly increased the sensitivity of latency III BL cells as well as that of lymphoblastoid cell lines to the polyphenol.	Polyphenols	298-308	PDZ and LIM domain 7	Homo sapiens	0-4
21267547-4	2011	In this communication, we have focused on the superiority of several classes of polyphenolic acetates to polyphenols in the modification of Cyt-P450-linked mixed function oxidases (MFOs) such as 7-ethoxyresorufin O-deethylase (EROD) and pentoxyresorufin O-dealkylase (PROD).	Polyphenols	105-116	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	140-148
21813650-3	2011	We have previously shown that two of the polyphenols from green tea (epigallocatechin gallate (EGCG) and epicatechin gallate (ECG)) inhibit GDH in vitro and that EGCG blocks GDH-mediated insulin secretion in wild type rat islets.	Polyphenols	41-52	glutamate dehydrogenase 1	Homo sapiens	140-143
21813650-3	2011	We have previously shown that two of the polyphenols from green tea (epigallocatechin gallate (EGCG) and epicatechin gallate (ECG)) inhibit GDH in vitro and that EGCG blocks GDH-mediated insulin secretion in wild type rat islets.	Polyphenols	41-52	glutamate dehydrogenase 1	Homo sapiens	174-177
21788573-8	2011	To define the role of PPARgamma in modulating polyphenol effects, small interfering RNA technique and PPARgamma antagonist were used to inhibit transcription factor activity.	Polyphenols	46-56	peroxisome proliferator activated receptor gamma	Homo sapiens	22-31
21788573-11	2011	It is interesting that PPARgamma inhibition counteracted the polyphenol-induced adiponectin and GLUT4 upregulations, suggesting a direct involvement of PPARgamma in this process.	Polyphenols	61-71	peroxisome proliferator activated receptor gamma	Homo sapiens	23-32
21788573-11	2011	It is interesting that PPARgamma inhibition counteracted the polyphenol-induced adiponectin and GLUT4 upregulations, suggesting a direct involvement of PPARgamma in this process.	Polyphenols	61-71	adiponectin, C1Q and collagen domain containing	Homo sapiens	80-91
21788573-11	2011	It is interesting that PPARgamma inhibition counteracted the polyphenol-induced adiponectin and GLUT4 upregulations, suggesting a direct involvement of PPARgamma in this process.	Polyphenols	61-71	solute carrier family 2 member 4	Homo sapiens	96-101
21788573-11	2011	It is interesting that PPARgamma inhibition counteracted the polyphenol-induced adiponectin and GLUT4 upregulations, suggesting a direct involvement of PPARgamma in this process.	Polyphenols	61-71	peroxisome proliferator activated receptor gamma	Homo sapiens	152-161
21293955-5	2011	In our study results, the mobile phone irradiation-induced increases in the content of active Bax were inhibited significantly by green tea polyphenols, while the contents of total Bax had no marked changes after the treatment of green tea polyphenols.	Polyphenols	140-151	BCL2 associated X, apoptosis regulator	Rattus norvegicus	94-97
21889055-2	2011	The total polyphenol and anthocyanin contents and the corresponding antioxidant activities were the highest at 13/10 C and 20/13 C, followed by 25/20 C and 30/25 C. The enzymatic activities of polyphenol oxidase (PPO) and phenylalanine ammonia-lyase (PAL) were also the highest at low day/night temperatures, but the peroxidase (POD) activity was decreased at low day/night temperatures and increased at high day/night temperatures.	Polyphenols	10-20	protoporphyrinogen oxidase	Homo sapiens	193-211
21654327-0	2011	High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice.	Polyphenols	32-42	sirtuin 1	Mus musculus	81-90
25214327-5	2011	Polyphenols decreased reactive oxygen species generation and increased the activity and the protein expression of the antioxidant enzymes catalase, superoxide dismutase, glutathione reductase and glutathione peroxidase.	Polyphenols	0-11	catalase	Homo sapiens	138-146
25214327-5	2011	Polyphenols decreased reactive oxygen species generation and increased the activity and the protein expression of the antioxidant enzymes catalase, superoxide dismutase, glutathione reductase and glutathione peroxidase.	Polyphenols	0-11	glutathione-disulfide reductase	Homo sapiens	170-191
21654327-0	2011	High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice.	Polyphenols	32-42	transformation related protein 53, pseudogene	Mus musculus	115-118
21654327-7	2011	These results indicate that high-fat diet increases and S17834 decreases the acetylation of p53 in lesion-prone aortic endothelial cells of normal mice independently of blood lipids, suggesting that the polyphenol may regulate endothelial cell p53 acetylation and apoptosis via local actions.	Polyphenols	203-213	transformation related protein 53, pseudogene	Mus musculus	92-95
21654327-1	2011	Our purpose was to determine if high-fat diet and treatment with a polyphenol regulate the acetylation of lysine-382 of p53, the site regulated by sirtuin-1, and apoptosis in the endothelium of the atherosclerotic lesion-prone mouse aortic arch.	Polyphenols	67-77	transformation related protein 53, pseudogene	Mus musculus	120-123
21654327-1	2011	Our purpose was to determine if high-fat diet and treatment with a polyphenol regulate the acetylation of lysine-382 of p53, the site regulated by sirtuin-1, and apoptosis in the endothelium of the atherosclerotic lesion-prone mouse aortic arch.	Polyphenols	67-77	sirtuin 1	Mus musculus	147-156
21861859-4	2011	In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1beta-induced inflammatory cytokines, TNFalpha, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes.	Polyphenols	59-69	interleukin 1 beta	Homo sapiens	109-117
21617900-5	2011	Three-m/o ATX mice were treated with the cardio-protective polyphenol catechin for 9 months.	Polyphenols	59-69	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	10-13
21756928-0	2011	Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFkappaB and AhR and EGFR-ERK pathway.	Polyphenols	6-17	nuclear factor kappa B subunit 1	Homo sapiens	144-152
21756928-0	2011	Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFkappaB and AhR and EGFR-ERK pathway.	Polyphenols	6-17	aryl hydrocarbon receptor	Homo sapiens	157-160
21756928-0	2011	Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFkappaB and AhR and EGFR-ERK pathway.	Polyphenols	6-17	epidermal growth factor receptor	Homo sapiens	165-169
21756928-0	2011	Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFkappaB and AhR and EGFR-ERK pathway.	Polyphenols	6-17	mitogen-activated protein kinase 1	Homo sapiens	170-173
21761876-1	2011	Polyphenols are known to induce vasodilatory function via activation of the redox-sensitive phosphatidylinositol-3 (PI3)/protein kinase B (Akt) pathway.	Polyphenols	0-11	AKT serine/threonine kinase 1	Homo sapiens	139-142
21548775-3	2011	One potential strategy to reduce inflammation and insulin resistance is consumption of polyphenol-rich foods like grapes or their by-products, which have anti-inflammatory properties.	Polyphenols	87-97	insulin	Homo sapiens	50-57
21861859-4	2011	In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1beta-induced inflammatory cytokines, TNFalpha, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes.	Polyphenols	59-69	tumor necrosis factor	Homo sapiens	150-158
21861859-4	2011	In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1beta-induced inflammatory cytokines, TNFalpha, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes.	Polyphenols	59-69	colony stimulating factor 2	Homo sapiens	166-214
21861859-5	2011	The use of green tea polyphenols may be beneficial as a therapeutic addition to biologics that control IL-1beta activity by increasing effectiveness and/or reducing dosage.	Polyphenols	21-32	interleukin 1 beta	Homo sapiens	103-111
21740906-0	2011	Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation.	Polyphenols	8-19	transthyretin	Homo sapiens	62-75
21740906-0	2011	Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation.	Polyphenols	8-19	transthyretin	Homo sapiens	77-80
21740906-2	2011	Herein, we studied modulation of transthyretin (TTR) fibrillogenesis by selected polyphenols.	Polyphenols	81-92	transthyretin	Homo sapiens	33-46
21740906-2	2011	Herein, we studied modulation of transthyretin (TTR) fibrillogenesis by selected polyphenols.	Polyphenols	81-92	transthyretin	Homo sapiens	48-51
21605053-7	2011	Indeed, polyphenols including resveratrol, EGCG and luteolin significantly inhibit the activation of the key apoptotic executioner, caspase-3 and are able to modulate mitogen-activated protein kinases known to play an important role in neuronal apoptosis.	Polyphenols	8-19	caspase 3	Homo sapiens	132-141
21385509-2	2011	Our aims were to determine whether the polyphenol resveratrol improves insulin sensitivity in type 2 diabetic patients and to gain some insight into the mechanism of its action.	Polyphenols	39-49	insulin	Homo sapiens	71-78
21605053-8	2011	Moreover, it has been reported that polyphenols may exert their anti-apoptotic action by inhibiting AIF release from mitochondria, thus providing new mechanism of action for polyphenols.	Polyphenols	36-47	apoptosis inducing factor mitochondria associated 1	Homo sapiens	100-103
21605053-5	2011	In particular, we have reported that polyphenols extracted from green tea (i.e. epigallocatechin gallate or EGCG) and red wine (i.e. resveratrol) block Abeta-induced hippocampal cell death, by at least partially inhibiting Abeta fibrillisation.	Polyphenols	37-48	amyloid beta precursor protein	Homo sapiens	152-157
21605053-5	2011	In particular, we have reported that polyphenols extracted from green tea (i.e. epigallocatechin gallate or EGCG) and red wine (i.e. resveratrol) block Abeta-induced hippocampal cell death, by at least partially inhibiting Abeta fibrillisation.	Polyphenols	37-48	amyloid beta precursor protein	Homo sapiens	223-228
21605053-8	2011	Moreover, it has been reported that polyphenols may exert their anti-apoptotic action by inhibiting AIF release from mitochondria, thus providing new mechanism of action for polyphenols.	Polyphenols	174-185	apoptosis inducing factor mitochondria associated 1	Homo sapiens	100-103
25214119-0	2011	Antimetastatic activity of polyphenol-rich extract of Ecklonia cava through the inhibition of the Akt pathway in A549 human lung cancer cells.	Polyphenols	27-37	AKT serine/threonine kinase 1	Homo sapiens	98-101
21550378-4	2011	In a previous study, we have shown that red wine polyphenol extract (PE) supplementation induces a decrease in plasma homocysteine level and an increase in hepatic Pon1 gene expression concomitant with an increase in hepatic and plasma Pon1 activity in a murine model of hyperhomocysteinemia.	Polyphenols	49-59	paraoxonase 1	Mus musculus	164-168
21550378-4	2011	In a previous study, we have shown that red wine polyphenol extract (PE) supplementation induces a decrease in plasma homocysteine level and an increase in hepatic Pon1 gene expression concomitant with an increase in hepatic and plasma Pon1 activity in a murine model of hyperhomocysteinemia.	Polyphenols	49-59	paraoxonase 1	Mus musculus	236-240
21966584-3	2011	Seeded aggregation of alpha-synuclein induced necrotic cell death, which was suppressed by the addition of various polyphenols.	Polyphenols	115-126	synuclein alpha	Homo sapiens	22-37
21620684-3	2011	OBJECTIVE: We compared effects of plant polyphenols (PPs) on the constitutive, UVA-, LPS-, or TNF-alpha-induced inflammatory responses in cultured normal human epidermal keratinocytes (NHEK) and immortalized HaCaT cells.	Polyphenols	40-51	tumor necrosis factor	Homo sapiens	94-103
21671331-4	2011	We find that eleven polyphenol aglycones of variable size and structure utilize the same remodeling pathway whereby Abeta oligomers are rapidly converted into large, off-pathway aggregates.	Polyphenols	20-30	amyloid beta precursor protein	Homo sapiens	116-121
21671331-5	2011	Strikingly, we find that glycosides of these polyphenols all utilize a distinct remodeling pathway in which Abeta oligomers are rapidly dissociated into soluble, disaggregated peptide.	Polyphenols	45-56	amyloid beta precursor protein	Homo sapiens	108-113
21671331-8	2011	Importantly, both classes of polyphenols fail to remodel nontoxic Abeta oligomers (which are indistinguishable in size and morphology to Abeta soluble oligomers) or promote aggregation of freshly disaggregated Abeta peptide; thus revealing that they are specific for remodeling toxic Abeta conformers.	Polyphenols	29-40	amyloid beta precursor protein	Homo sapiens	66-71
21317920-4	2011	We have previously shown that curcumin, a natural polyphenol, enhances paclitaxel-induced cytotoxicity in vitro through downregulation of nuclear factor (NF)-kappaB and Akt pathways.	Polyphenols	50-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	138-164
21354237-6	2011	We also propose that the NMA encoded multiple receptor conformations (MRC) of BACE1 elucidate the pharmacophoric feature necessary to inhibit the enzyme by a polyphenol, myricetin.	Polyphenols	158-168	beta-secretase 1	Homo sapiens	78-83
21574661-0	2011	Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.	Polyphenols	72-82	signal transducer and activator of transcription 1	Mus musculus	139-144
21574661-0	2011	Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.	Polyphenols	72-82	signal transducer and activator of transcription 3	Mus musculus	149-154
21932511-3	2011	Moreover, resveratrol (RSV), a plant derived polyphenol, was shown to increase SIRT1 catalytic activity and mimics many aspects of CR in all eukaryotes tested.	Polyphenols	45-55	sirtuin 1	Homo sapiens	79-84
21613676-1	2011	The aim of the study was to evaluate the effect of red wine polyphenols extract Provinols  on the development of cardiovascular injury in the model of carbon tetrachloride (CCl4) intoxication.	Polyphenols	60-71	C-C motif chemokine ligand 4	Rattus norvegicus	173-177
21613676-1	2011	The aim of the study was to evaluate the effect of red wine polyphenols extract Provinols  on the development of cardiovascular injury in the model of carbon tetrachloride (CCl4) intoxication.	Polyphenols	80-89	C-C motif chemokine ligand 4	Rattus norvegicus	173-177
21613676-8	2011	The results revealed beneficial effects of red wine polyphenols on vascular function injured by chronic CCl4 intoxication.	Polyphenols	52-63	C-C motif chemokine ligand 4	Rattus norvegicus	104-108
21255696-0	2011	Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts.	Polyphenols	10-20	C-X-C motif chemokine ligand 10	Homo sapiens	30-36
21255696-0	2011	Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts.	Polyphenols	10-20	oncostatin M	Homo sapiens	51-63
21442225-5	2011	This investigation is the first to report that Ddc-GAL4 transgenic flies chronically fed with polyphenols increase life span (P < 0.05 by log-rang test) and enhance movement abilities (P < 0.05 by chi(2) test) compared to untreated Ddc-GAL4 or treated with paraquat in 1% glucose.	Polyphenols	94-105	Dopa decarboxylase	Drosophila melanogaster	47-50
21442225-5	2011	This investigation is the first to report that Ddc-GAL4 transgenic flies chronically fed with polyphenols increase life span (P < 0.05 by log-rang test) and enhance movement abilities (P < 0.05 by chi(2) test) compared to untreated Ddc-GAL4 or treated with paraquat in 1% glucose.	Polyphenols	94-105	Dopa decarboxylase	Drosophila melanogaster	232-235
21466813-0	2011	Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells.	Polyphenols	46-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	103-109
21459323-5	2011	Hepatic activation of AMPK by the synthetic polyphenol S17834 protects against hepatic steatosis, hyperlipidemia, and accelerated atherosclerosis in diet-induced insulin-resistant LDL receptor-deficient mice in part through phosphorylation of SREBP-1c Ser372 and suppression of SREBP-1c- and -2-dependent lipogenesis.	Polyphenols	44-54	sterol regulatory element binding transcription factor 1	Mus musculus	243-251
21481816-2	2011	The 50% inhibition concentration values (IC(50)) for most of the tested polyphenols are between 8 and 480 muM for copper-mediated DNA damage prevention.	Polyphenols	72-83	latexin	Homo sapiens	106-109
21459323-3	2011	Ser372 phosphorylation of SREBP-1c by AMPK is necessary for inhibition of proteolytic processing and transcriptional activity of SREBP-1c in response to polyphenols and metformin.	Polyphenols	153-164	sterol regulatory element binding transcription factor 1	Mus musculus	26-34
21789892-0	2011	Tea polyphenol-induced neuron-like differentiation of mouse mesenchymal stem cells.	Polyphenols	4-14	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
21510884-0	2011	The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols.	Polyphenols	98-109	DNA methyltransferase 3 alpha	Homo sapiens	32-56
21510884-0	2011	The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols.	Polyphenols	98-109	DNA methyltransferase 3 alpha	Homo sapiens	58-64
21510884-3	2011	RESULTS: We studied the inhibition of DNA methyltransferase 3a by a series of dietary polyphenols from black tea such as theaflavins and thearubigins and chlorogenic acid derivatives from coffee.	Polyphenols	86-97	DNA methyltransferase 3 alpha	Homo sapiens	38-62
21459323-3	2011	Ser372 phosphorylation of SREBP-1c by AMPK is necessary for inhibition of proteolytic processing and transcriptional activity of SREBP-1c in response to polyphenols and metformin.	Polyphenols	153-164	sterol regulatory element binding transcription factor 1	Mus musculus	129-137
21459323-5	2011	Hepatic activation of AMPK by the synthetic polyphenol S17834 protects against hepatic steatosis, hyperlipidemia, and accelerated atherosclerosis in diet-induced insulin-resistant LDL receptor-deficient mice in part through phosphorylation of SREBP-1c Ser372 and suppression of SREBP-1c- and -2-dependent lipogenesis.	Polyphenols	44-54	sterol regulatory element binding transcription factor 1	Mus musculus	278-294
20977430-0	2011	Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase.	Polyphenols	9-20	endothelin 1	Rattus norvegicus	64-76
21483037-3	2011	SIRT1 is one of the targets of resveratrol, a polyphenol that has been shown to increase lifespan and to protect animal models against high-calorie diet induced obesity and insulin resistance.	Polyphenols	46-56	sirtuin 1	Homo sapiens	0-5
21483037-3	2011	SIRT1 is one of the targets of resveratrol, a polyphenol that has been shown to increase lifespan and to protect animal models against high-calorie diet induced obesity and insulin resistance.	Polyphenols	46-56	insulin	Homo sapiens	173-180
20977430-1	2011	RWPs (red wine polyphenols) exert antihypertensive effects and improve endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O(2)( -) (superoxide anion).	Polyphenols	15-26	endothelin 1	Rattus norvegicus	125-129
20977430-1	2011	RWPs (red wine polyphenols) exert antihypertensive effects and improve endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O(2)( -) (superoxide anion).	Polyphenols	15-26	endothelin 1	Rattus norvegicus	131-143
21468567-3	2011	In the present study, we investigated the effect of (-)-epigallocatechin gallate (EGCG), the predominant green tea polyphenol, on the synthesis of osteocalcin in MC3T3-E1 cells.	Polyphenols	115-125	bone gamma-carboxyglutamate protein 2	Mus musculus	147-158
21329350-0	2011	Cinnamon polyphenol extract regulates tristetraprolin and related gene expression in mouse adipocytes.	Polyphenols	9-19	zinc finger protein 36	Mus musculus	38-53
21186270-2	2011	We hypothesized that a chronic treatment with the polyphenol catechin would prevent endothelial dysfunction, maintain CBF responses, and protect learning abilities in atherosclerotic (ATX) mice.	Polyphenols	50-60	diencephalon/mesencephalon homeobox 1	Mus musculus	184-187
21177307-0	2011	Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer.	Polyphenols	10-20	androgen receptor	Homo sapiens	33-50
19936622-0	2011	Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.	Polyphenols	26-37	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	51-67
19936622-0	2011	Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.	Polyphenols	26-37	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
19936622-0	2011	Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.	Polyphenols	26-37	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	122-125
21269399-3	2011	Resveratrol, a plant polyphenol, is reported to activate endothelial NO synthase (eNOS) through activation of sirtuin 1.	Polyphenols	21-31	sirtuin 1	Rattus norvegicus	110-119
21320497-0	2011	Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor.	Polyphenols	10-20	toll like receptor 2	Homo sapiens	57-61
21320497-0	2011	Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor.	Polyphenols	10-20	ribosomal protein SA	Homo sapiens	137-160
20652274-5	2011	RESULTS: In colon and liver of rats consuming polyphenol-free control juice, rather similar basic expressions were observed (relative GAPDH ratios ranging from 2 to 0.7 and 2.5-0.3, respectively).	Polyphenols	46-56	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	134-139
21149440-10	2011	Moreover, resveratrol, a plant polyphenol activator of SIRT1, increases FoxO1-dependent SIRT1 transcription activity and thus induces its expression.	Polyphenols	31-41	sirtuin 1	Homo sapiens	55-60
21370452-0	2011	Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced alpha9-nicotinic acetylcholine receptor upregulation in human breast cancer cells.	Polyphenols	4-14	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	86-125
21207142-1	2011	We investigated whether polyphenols modulate the expression and activity of the enzymes gelatinases A (MMP-2) and B (MMP-9), involved in the pathogenesis of multiple sclerosis (MS).	Polyphenols	24-35	matrix metallopeptidase 2	Rattus norvegicus	103-115
21207142-1	2011	We investigated whether polyphenols modulate the expression and activity of the enzymes gelatinases A (MMP-2) and B (MMP-9), involved in the pathogenesis of multiple sclerosis (MS).	Polyphenols	24-35	matrix metallopeptidase 9	Rattus norvegicus	117-122
21149440-10	2011	Moreover, resveratrol, a plant polyphenol activator of SIRT1, increases FoxO1-dependent SIRT1 transcription activity and thus induces its expression.	Polyphenols	31-41	forkhead box O1	Homo sapiens	72-77
21149440-10	2011	Moreover, resveratrol, a plant polyphenol activator of SIRT1, increases FoxO1-dependent SIRT1 transcription activity and thus induces its expression.	Polyphenols	31-41	sirtuin 1	Homo sapiens	88-93
21204551-2	2011	The oxidation products, flavan-3,4-diols and the corresponding C-4 ketones, are bioactive compounds and useful intermediates for the hemisynthesis of proanthocyanidins, plant polyphenols which provide beneficial health properties for humans.	Polyphenols	175-186	complement C4A (Rodgers blood group)	Homo sapiens	63-66
21163639-2	2011	The electrode was fabricated by entrapping glucose oxidase (GOx) and hexokinase (HEX) in a poly-phenol film on a Pt microelectrode.	Polyphenols	91-102	hydroxyacid oxidase 1	Homo sapiens	43-58
21163639-2	2011	The electrode was fabricated by entrapping glucose oxidase (GOx) and hexokinase (HEX) in a poly-phenol film on a Pt microelectrode.	Polyphenols	91-102	hydroxyacid oxidase 1	Homo sapiens	60-63
21163639-2	2011	The electrode was fabricated by entrapping glucose oxidase (GOx) and hexokinase (HEX) in a poly-phenol film on a Pt microelectrode.	Polyphenols	91-102	hexokinase 1	Homo sapiens	69-79
21163639-2	2011	The electrode was fabricated by entrapping glucose oxidase (GOx) and hexokinase (HEX) in a poly-phenol film on a Pt microelectrode.	Polyphenols	91-102	hexokinase 1	Homo sapiens	81-84
21434871-9	2011	Taken together, these results support a role for NADPH oxidase-mediated ROS production in the cytotoxic effects of Abeta, and demonstrate the therapeutic potential of EGCG and other dietary polyphenols in delaying onset or retarding the progression of AD.	Polyphenols	190-201	amyloid beta precursor protein	Homo sapiens	115-120
21190524-6	2011	In addition, this review will also highlight two new areas of development: 1) attenuation of Met signaling via multiple mechanisms of action targeting tumor cells and cells in the surrounding stroma using plant-derived polyphenols and 2) the induction by HGF of atypical lysosome trafficking, leading to increased protease secretion and tumor cell invasion.	Polyphenols	219-230	hepatocyte growth factor	Homo sapiens	255-258
21093416-8	2011	Certain drugs (e.g. hypolipemic and anti-diabetic compounds), dietary factors (antioxidants, polyphenols), and life-style factors (moderate alcohol consumption) appear to increase PON1 activity.	Polyphenols	93-104	paraoxonase 1	Homo sapiens	180-184
21204775-2	2011	Resveratrol (Rsv), a polyphenol that extends the lifespan of diverse species is an activator of SIRT1, a NAD(+) dependent deacetylating enzyme in mammalian cells.	Polyphenols	21-31	sirtuin 1	Homo sapiens	96-101
21099366-10	2011	Our findings suggest that the Nrf2/ARE pathway plays an important part in the cooperative induction of myeloid leukemia cell differentiation by 1,25D and a plant polyphenol.	Polyphenols	162-172	GA binding protein transcription factor subunit alpha	Homo sapiens	30-34
20952447-0	2011	ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington"s disease.	Polyphenols	22-33	Eph receptor B1	Rattus norvegicus	0-3
21437031-0	2011	Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells.	Polyphenols	21-32	fatty acid synthase	Homo sapiens	36-55
21487492-11	2011	It was concluded that polyphenols (72 mg/day), including serotonin derivatives, in the Saf-tea had both antioxidant and potential bone protecting effects in postmenopausal women without liver toxicity.	Polyphenols	22-33	FAS antisense RNA 1	Homo sapiens	87-90
20952447-4	2011	To test the hypothesis that pharmaceutical activation of ERK might be protective for HD, a polyphenol, fisetin, which was previously shown to activate the Ras-ERK cascade, was tested in three different models of HD: PC12 cells expressing mutant Httex1 under the control of an inducible promoter, Drosophila expressing mutant Httex1 and the R6/2 mouse model of HD.	Polyphenols	91-101	Eph receptor B1	Rattus norvegicus	57-60
20952447-6	2011	Prompted by this observation, we determined that the related polyphenol, resveratrol, also activates ERK and is protective in HD models.	Polyphenols	61-71	mitogen-activated protein kinase 1	Mus musculus	101-104
22254182-7	2011	We propose that control of eotaxin-1 expression and release by proinflammatory cytokines in HPAEC may be considered as an in vitro model for screening and discovering polyphenols with anti-inflammatory activities and cardioprotective potentials.	Polyphenols	167-178	C-C motif chemokine ligand 11	Homo sapiens	27-36
21261652-5	2011	The polyphenol resveratrol activates SIRT1 in an in vitro assay, and produces changes that resemble CR in vivo, including improvements in insulin sensitivity, endurance, and overall survival in obese mice.	Polyphenols	4-14	sirtuin 1	Mus musculus	37-42
21821919-0	2011	Polyphenols in alcoholic beverages activating constitutive androstane receptor CAR.	Polyphenols	0-11	CXADR pseudogene 1	Homo sapiens	79-82
21467630-3	2011	From the comprehensive screening of natural sources for inhibitors of spermidine-induced pro-PHBP autoactivation, we identified several compounds with a polyphenol feature.	Polyphenols	153-163	hyaluronan binding protein 2	Homo sapiens	93-97
21597194-1	2011	Chlorogenic acid (CQA) is one of the major polyphenols in apple and a good substrate for the polyphenol oxidase (PPO) in apple.	Polyphenols	43-54	polyphenol oxidase, chloroplastic	Malus domestica	113-116
22142871-1	2011	AIMS: The present study was carried out to investigate the antiatherosclerotic effect of antioxidant polyphenols from Phellinus baumii (PBE) in apolipoprotein E-deficient (apoE-/-) mice.	Polyphenols	101-112	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	Mus musculus	136-139
22142871-1	2011	AIMS: The present study was carried out to investigate the antiatherosclerotic effect of antioxidant polyphenols from Phellinus baumii (PBE) in apolipoprotein E-deficient (apoE-/-) mice.	Polyphenols	101-112	apolipoprotein E	Mus musculus	172-176
20883830-0	2011	Inhibition of 17beta-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John"s Wort and several natural polyphenols.	Polyphenols	132-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51
20883830-9	2011	The data suggest that risk of estrogen-mediated diseases might be not only influenced by CYP1A1 genotype-dependent activation but also its inhibition by natural polyphenols of our diet and drugs.	Polyphenols	161-172	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	89-95
21821919-1	2011	The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins.	Polyphenols	108-119	CXADR pseudogene 1	Homo sapiens	37-40
21821919-5	2011	Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR.	Polyphenols	96-107	CXADR pseudogene 1	Homo sapiens	6-9
21821919-5	2011	Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR.	Polyphenols	96-107	CXADR pseudogene 1	Homo sapiens	194-197
32272532-7	2011	The other polyphenols (rosmarinic acid, resveratrol, and epigallocatechin gallate at 10 - 30 muM) had no effect on SOCE and showed only a partial inhibition of the K+ currents.	Polyphenols	10-21	latexin	Homo sapiens	93-96
20861738-0	2011	The role of dietary polyphenols in tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis for cancer chemoprevention.	Polyphenols	20-31	TNF superfamily member 10	Homo sapiens	35-90
20861738-0	2011	The role of dietary polyphenols in tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis for cancer chemoprevention.	Polyphenols	20-31	TNF superfamily member 10	Homo sapiens	92-97
20861738-3	2011	In this review, we describe dietary polyphenols targeting the tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptotic pathway.	Polyphenols	36-47	TNF superfamily member 10	Homo sapiens	62-117
20861738-3	2011	In this review, we describe dietary polyphenols targeting the tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptotic pathway.	Polyphenols	36-47	TNF superfamily member 10	Homo sapiens	119-124
20861738-8	2011	There is a growing body of experimental evidence showing that polyphenols sensitize TRAIL-resistant cancer cells and markedly augment TRAIL-induced programmed death in cancer cells.	Polyphenols	62-73	TNF superfamily member 10	Homo sapiens	84-89
20861738-8	2011	There is a growing body of experimental evidence showing that polyphenols sensitize TRAIL-resistant cancer cells and markedly augment TRAIL-induced programmed death in cancer cells.	Polyphenols	62-73	TNF superfamily member 10	Homo sapiens	134-139
20861738-9	2011	These in-vitro and in-vivo studies indicate the significance of dietary polyphenols in cancer chemoprevention strategies through enhancing the apoptosis-inducing potential of TRAIL.	Polyphenols	72-83	TNF superfamily member 10	Homo sapiens	175-180
22181980-5	2011	Tea polyphenols are reported to have excellent chemopreventive properties against cancer.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
22181980-9	2011	Thus, tea polyphenols may prove effective in treating arsenic-induced carcinogenesis.	Polyphenols	10-21	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
22179005-5	2011	In addition, curcumin, a natural polyphenol derived from the plant Curcuma longa, effectively blocked Kv11.1 activity and also inhibited the proliferation of these cells.	Polyphenols	33-43	potassium voltage-gated channel modifier subfamily V member 2	Homo sapiens	102-108
22389857-5	2011	Although oral administration of tea polyphenols alone significantly decreased SBP in SHR at 2 and 4 hr, combined administration with Ameal failed to decrease SBP at the same time points.	Polyphenols	36-47	selenium binding protein 1	Homo sapiens	78-81
20943792-1	2010	BACKGROUND: Quercetin and trans-resveratrol (trans-RSV) are plant polyphenols reported to reduce inflammation or insulin resistance associated with obesity.	Polyphenols	66-77	insulin	Homo sapiens	113-120
21598179-0	2011	Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97).	Polyphenols	10-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	81-86
21598179-0	2011	Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97).	Polyphenols	10-20	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	91-96
21598179-8	2011	Polyphenol metabolites did not affect cell number but significantly upregulated GSTT2 expression and decreased COX-2.	Polyphenols	0-10	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	80-85
21598179-8	2011	Polyphenol metabolites did not affect cell number but significantly upregulated GSTT2 expression and decreased COX-2.	Polyphenols	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-116
21598179-11	2011	An upregulation of GSTT2 and downregulation of COX-2 could possibly contribute to the chemopreventive potential of polyphenols after degradation in the gut.	Polyphenols	115-126	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	19-24
21598179-11	2011	An upregulation of GSTT2 and downregulation of COX-2 could possibly contribute to the chemopreventive potential of polyphenols after degradation in the gut.	Polyphenols	115-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
21887248-0	2011	Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53.	Polyphenols	26-36	transformation related protein 53, pseudogene	Mus musculus	136-139
21041086-1	2010	The iron-ion catalyzed oxidation of the ethanol solution of rosmarinic acid, a potent antioxidant polyphenol of Lamiaceae (Labiatae) plants, afforded a highly tyrosinase-inhibitory active product.	Polyphenols	98-108	tyrosinase	Homo sapiens	159-169
21776820-0	2011	Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells.	Polyphenols	4-15	nuclear factor kappa B subunit 1	Homo sapiens	81-102
21776820-0	2011	Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells.	Polyphenols	4-15	AKT serine/threonine kinase 1	Homo sapiens	107-110
21776820-7	2011	Thus, we can conclude that tea polyphenols inhibit the growth of cervical cancer cells by inducing apoptosis and regulating NF-kappaB and Akt.	Polyphenols	31-42	nuclear factor kappa B subunit 1	Homo sapiens	124-133
21776820-7	2011	Thus, we can conclude that tea polyphenols inhibit the growth of cervical cancer cells by inducing apoptosis and regulating NF-kappaB and Akt.	Polyphenols	31-42	AKT serine/threonine kinase 1	Homo sapiens	138-141
22129860-9	2011	Red wine polyphenols have been suggested to improve the swallowing reflex by increasing TRPV1 response.	Polyphenols	9-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
20393885-1	2010	Recent reports describe the inhibition of human dihydrofolate reductase (hDHFR) by natural tea polyphenols.	Polyphenols	95-106	dihydrofolate reductase	Homo sapiens	48-71
20214496-2	2010	Lupin is a source of polyphenols, protein, and L-arginine, factors that may influence blood pressure via effects on oxidative stress and vascular function.	Polyphenols	21-32	5'-nucleotidase, cytosolic IIIA	Homo sapiens	0-5
20673376-3	2010	The present study was designed to determine whether a polyphenol extract (PPE), from red grapes, modulates liver fatty acid composition and desaturase activity indexes in rats fed a high-fat-high-sucrose (HFHS) diet, and to explore whether sirtuin-1 deacetylase activation was implicated in the effect of the PPE against liver steatosis.	Polyphenols	54-64	sirtuin 1	Rattus norvegicus	240-249
20730438-6	2010	DISCUSSION: The gene expression arrays and quantitative RT-PCR suggested that tea polyphenol inhibited the gene expression of metallothionein 2A (MT2A), transcription factor (MAFA), hairy and enhancer of split 1 (HES1), and jagged1 (JAG1) nearly twofold over controls.	Polyphenols	82-92	metallothionein 2A	Homo sapiens	126-144
20730438-6	2010	DISCUSSION: The gene expression arrays and quantitative RT-PCR suggested that tea polyphenol inhibited the gene expression of metallothionein 2A (MT2A), transcription factor (MAFA), hairy and enhancer of split 1 (HES1), and jagged1 (JAG1) nearly twofold over controls.	Polyphenols	82-92	metallothionein 2A	Homo sapiens	146-150
20730438-6	2010	DISCUSSION: The gene expression arrays and quantitative RT-PCR suggested that tea polyphenol inhibited the gene expression of metallothionein 2A (MT2A), transcription factor (MAFA), hairy and enhancer of split 1 (HES1), and jagged1 (JAG1) nearly twofold over controls.	Polyphenols	82-92	MAF bZIP transcription factor A	Homo sapiens	175-179
20730438-6	2010	DISCUSSION: The gene expression arrays and quantitative RT-PCR suggested that tea polyphenol inhibited the gene expression of metallothionein 2A (MT2A), transcription factor (MAFA), hairy and enhancer of split 1 (HES1), and jagged1 (JAG1) nearly twofold over controls.	Polyphenols	82-92	hes family bHLH transcription factor 1	Homo sapiens	182-211
20730438-6	2010	DISCUSSION: The gene expression arrays and quantitative RT-PCR suggested that tea polyphenol inhibited the gene expression of metallothionein 2A (MT2A), transcription factor (MAFA), hairy and enhancer of split 1 (HES1), and jagged1 (JAG1) nearly twofold over controls.	Polyphenols	82-92	hes family bHLH transcription factor 1	Homo sapiens	213-217
20730438-6	2010	DISCUSSION: The gene expression arrays and quantitative RT-PCR suggested that tea polyphenol inhibited the gene expression of metallothionein 2A (MT2A), transcription factor (MAFA), hairy and enhancer of split 1 (HES1), and jagged1 (JAG1) nearly twofold over controls.	Polyphenols	82-92	jagged canonical Notch ligand 1	Homo sapiens	224-231
20730438-6	2010	DISCUSSION: The gene expression arrays and quantitative RT-PCR suggested that tea polyphenol inhibited the gene expression of metallothionein 2A (MT2A), transcription factor (MAFA), hairy and enhancer of split 1 (HES1), and jagged1 (JAG1) nearly twofold over controls.	Polyphenols	82-92	jagged canonical Notch ligand 1	Homo sapiens	233-237
20730438-7	2010	It was also found that tea polyphenol inhibited the BAX and p38 genes with a more than twofold difference but did not significantly inhibited the NFkappaB pathway.	Polyphenols	27-37	BCL2 associated X, apoptosis regulator	Homo sapiens	52-55
20730438-7	2010	It was also found that tea polyphenol inhibited the BAX and p38 genes with a more than twofold difference but did not significantly inhibited the NFkappaB pathway.	Polyphenols	27-37	mitogen-activated protein kinase 14	Homo sapiens	60-63
20730438-9	2010	Tea polyphenol inhibited the gene expression of HES1, JAG1, MT2A, and MAFA but upregulated the gene expression of BAX and downregulated that of (P)38.	Polyphenols	4-14	hes family bHLH transcription factor 1	Homo sapiens	48-52
20730438-9	2010	Tea polyphenol inhibited the gene expression of HES1, JAG1, MT2A, and MAFA but upregulated the gene expression of BAX and downregulated that of (P)38.	Polyphenols	4-14	jagged canonical Notch ligand 1	Homo sapiens	54-58
20730438-9	2010	Tea polyphenol inhibited the gene expression of HES1, JAG1, MT2A, and MAFA but upregulated the gene expression of BAX and downregulated that of (P)38.	Polyphenols	4-14	metallothionein 2A	Homo sapiens	60-64
20730438-9	2010	Tea polyphenol inhibited the gene expression of HES1, JAG1, MT2A, and MAFA but upregulated the gene expression of BAX and downregulated that of (P)38.	Polyphenols	4-14	MAF bZIP transcription factor A	Homo sapiens	70-74
20730438-9	2010	Tea polyphenol inhibited the gene expression of HES1, JAG1, MT2A, and MAFA but upregulated the gene expression of BAX and downregulated that of (P)38.	Polyphenols	4-14	BCL2 associated X, apoptosis regulator	Homo sapiens	114-117
20936703-0	2010	Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species.	Polyphenols	10-21	nerve growth factor	Rattus norvegicus	47-66
20936703-3	2010	Using the PC12 cell model, we show here that unfractionated green tea polyphenols (GTPP) at low concentrations (0.1 mug/ml) potentiate the ability of low concentrations of NGF (2 ng/ml) to induce neuritogenesis at a level comparable to that induced by optimally high concentrations of NGF (50 ng/ml) alone.	Polyphenols	70-81	nerve growth factor	Rattus norvegicus	172-175
20936703-3	2010	Using the PC12 cell model, we show here that unfractionated green tea polyphenols (GTPP) at low concentrations (0.1 mug/ml) potentiate the ability of low concentrations of NGF (2 ng/ml) to induce neuritogenesis at a level comparable to that induced by optimally high concentrations of NGF (50 ng/ml) alone.	Polyphenols	70-81	nerve growth factor	Rattus norvegicus	285-288
20936703-5	2010	Among the polyphenols present in GTPP, epigallocatechin-3-gallate (EGCG) alone appreciably potentiated NGF-induced neurite outgrowth.	Polyphenols	10-21	nerve growth factor	Rattus norvegicus	103-106
20936703-11	2010	Taken together, these results show for the first time that GTPP potentiates NGF-induced neuritogenesis, likely through the involvement of sublethal levels of reactive oxygen species, and suggest that unfractionated GTPP is more effective in this respect than its fractionated polyphenols.	Polyphenols	276-287	nerve growth factor	Rattus norvegicus	76-79
20393885-1	2010	Recent reports describe the inhibition of human dihydrofolate reductase (hDHFR) by natural tea polyphenols.	Polyphenols	95-106	dihydrofolate reductase	Homo sapiens	73-78
22254000-4	2010	For example, their ability to activate ERK in neurons leads to a promotion of neuronal survival and cognitive enhancements, both of which influence the progression of Alzheimer"s disease, whilst ERK activation by polyphenols in vascular endothelial cells influences nitric oxide production, blood pressure and ultimately CVD risk.	Polyphenols	213-224	mitogen-activated protein kinase 1	Homo sapiens	39-42
20937024-10	2010	Genistein, alpha-difluoromethylornithine, toremifene, R-flurbiprofen, celecoxib, and green tea polyphenols have been shown to prevent prostate cancer development in TRAMP mice.	Polyphenols	95-106	tumor necrosis factor receptor superfamily, member 25	Mus musculus	165-170
20837173-4	2010	Adsorption of the polyphenols to cell surfaces and their accumulation within cells were assessed by detection of the H(2)O(2) precursor O(2)(-) produced by the compounds through reduction of cytochrome c and p-nitro-blue tetrazolium, respectively.	Polyphenols	18-29	cytochrome c, somatic	Homo sapiens	191-203
19962294-14	2010	These results demonstrate that EGCG, a green tea polyphenol, may reduce up-regulation of MMP-9 activity and neuronal damage following transient focal cerebral ischemia.	Polyphenols	49-59	matrix metallopeptidase 9	Mus musculus	89-94
19962294-15	2010	In addition to its antioxidant effect, MMP-9 inhibition might be a possible mechanism potentially involved in the neuroprotective effect of a green tea polyphenol, EGCG.	Polyphenols	152-162	matrix metallopeptidase 9	Mus musculus	39-44
22254000-4	2010	For example, their ability to activate ERK in neurons leads to a promotion of neuronal survival and cognitive enhancements, both of which influence the progression of Alzheimer"s disease, whilst ERK activation by polyphenols in vascular endothelial cells influences nitric oxide production, blood pressure and ultimately CVD risk.	Polyphenols	213-224	mitogen-activated protein kinase 1	Homo sapiens	195-198
20801100-4	2010	Our data shows a rapid formation of alpha-synuclein amyloid fibrils was stimulated by 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [BIMbF(3)Im], and these fibrils could be disaggregated by polyphenols such as epigallocatechin gallate (EGCG) and baicalein.	Polyphenols	206-217	synuclein alpha	Homo sapiens	36-51
20626032-1	2010	The polyphenol quercetin (Quer) represses expression of the cardiovascular disease risk factor plasminogen activator inhibitor-1 (PAI-1) in cultured endothelial cells (ECs).	Polyphenols	4-14	serpin family E member 1	Homo sapiens	95-128
20626032-1	2010	The polyphenol quercetin (Quer) represses expression of the cardiovascular disease risk factor plasminogen activator inhibitor-1 (PAI-1) in cultured endothelial cells (ECs).	Polyphenols	4-14	serpin family E member 1	Homo sapiens	130-135
20626032-7	2010	Quer-induced decreases in PAI-1 expression and reduced cell proliferation may contribute, at least in part, to the cardioprotective benefit associated with daily intake of polyphenols.	Polyphenols	172-183	serpin family E member 1	Homo sapiens	26-31
20946668-0	2010	Synergistic epigenetic reactivation of estrogen receptor-alpha (ERalpha) by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells.	Polyphenols	95-105	estrogen receptor 1	Homo sapiens	39-62
20946668-0	2010	Synergistic epigenetic reactivation of estrogen receptor-alpha (ERalpha) by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells.	Polyphenols	95-105	estrogen receptor 1	Homo sapiens	64-71
20946668-0	2010	Synergistic epigenetic reactivation of estrogen receptor-alpha (ERalpha) by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells.	Polyphenols	95-105	estrogen receptor 1	Homo sapiens	143-150
20109516-12	2010	Further, CRTAase was also found capable of transferring propionyl group from a propoxy derivative of polyphenol, 7,8-Dipropoxy-4-methylcoumarin (DPMC) to RP and concomitant autopropionylation of CR was encountered.	Polyphenols	101-111	calreticulin	Homo sapiens	9-11
20550744-0	2010	Cocoa polyphenols suppress TNF-alpha-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells.	Polyphenols	6-17	tumor necrosis factor	Mus musculus	27-36
20550744-0	2010	Cocoa polyphenols suppress TNF-alpha-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells.	Polyphenols	6-17	vascular endothelial growth factor A	Mus musculus	45-79
20550744-0	2010	Cocoa polyphenols suppress TNF-alpha-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells.	Polyphenols	6-17	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	105-130
20550744-0	2010	Cocoa polyphenols suppress TNF-alpha-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells.	Polyphenols	6-17	mitogen-activated protein kinase kinase 1	Mus musculus	142-183
20550744-0	2010	Cocoa polyphenols suppress TNF-alpha-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells.	Polyphenols	6-17	mitogen-activated protein kinase kinase 1	Mus musculus	185-189
20550744-4	2010	We tested whether cocoa polyphenol extract (CPE) inhibited TNF-alpha-induced VEGF expression in promotion-sensitive JB6 mouse epidermal cells.	Polyphenols	24-34	tumor necrosis factor	Mus musculus	59-68
20550744-4	2010	We tested whether cocoa polyphenol extract (CPE) inhibited TNF-alpha-induced VEGF expression in promotion-sensitive JB6 mouse epidermal cells.	Polyphenols	24-34	vascular endothelial growth factor A	Mus musculus	77-81
20606002-0	2010	O-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols.	Polyphenols	178-189	catechol-O-methyltransferase	Homo sapiens	55-83
20606002-7	2010	It was observed that there was a positive correlation (r = 0.760) between the sensitivity of the human placental COMT to heat inactivation and its sensitivity to inhibition by (-)-epigallocatechin-3-gallate (a well known tea polyphenol with COMT-inhibiting activity) but an inverse correlation (r = 0.544) between heat inactivation and inhibition by quercetin (another dietary COMT inhibitor).	Polyphenols	225-235	catechol-O-methyltransferase	Homo sapiens	113-117
20522783-3	2010	We establish that SphK1 is a downstream effector of the ERK/phospholipase D (PLD) pathway, which is inhibited by green tea and wine polyphenols.	Polyphenols	132-143	sphingosine kinase 1	Homo sapiens	18-23
20522783-3	2010	We establish that SphK1 is a downstream effector of the ERK/phospholipase D (PLD) pathway, which is inhibited by green tea and wine polyphenols.	Polyphenols	132-143	mitogen-activated protein kinase 1	Homo sapiens	56-59
20522783-3	2010	We establish that SphK1 is a downstream effector of the ERK/phospholipase D (PLD) pathway, which is inhibited by green tea and wine polyphenols.	Polyphenols	132-143	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	77-80
20522783-4	2010	Enforced expression of SphK1 impaired the ability of green tea and wine polyphenols, as well as pharmacological inhibitors of PLD and ERK activities, to induce apoptosis in PC-3 and C4-2B cells.	Polyphenols	72-83	sphingosine kinase 1	Homo sapiens	23-28
20522783-5	2010	The therapeutic efficacy of these polyphenols on tumor growth and the SphK1/S1P pathway were confirmed in animals using a heterotopic PC-3 tumor in place model.	Polyphenols	34-45	membrane bound transcription factor peptidase, site 1	Homo sapiens	76-79
20522783-6	2010	PC-3/SphK1 cells implanted in animals developed larger tumors and resistance to treatment with polyphenols.	Polyphenols	95-106	sphingosine kinase 1	Homo sapiens	5-10
20522783-8	2010	These results provide the first demonstration that the prosurvival, antiapoptotic SphK1/S1P pathway represents a target of dietary green tea and wine polyphenols in cancer.	Polyphenols	150-161	sphingosine kinase 1	Homo sapiens	82-87
20522783-8	2010	These results provide the first demonstration that the prosurvival, antiapoptotic SphK1/S1P pathway represents a target of dietary green tea and wine polyphenols in cancer.	Polyphenols	150-161	membrane bound transcription factor peptidase, site 1	Homo sapiens	88-91
21495460-12	2010	CONCLUSION: The APH-ammonium persulfate system can be used for spectrophotometric determination of total polyphenols in different systems.	Polyphenols	105-116	acylaminoacyl-peptide hydrolase	Homo sapiens	16-19
20450879-0	2010	Regulation of SIRT1 in cellular functions: role of polyphenols.	Polyphenols	51-62	sirtuin 1	Homo sapiens	14-19
20450879-3	2010	In addition, these polyphenols have also been shown to activate SIRT1 directly or indirectly in a variety of models.	Polyphenols	19-30	sirtuin 1	Homo sapiens	64-69
20450879-4	2010	Therefore, activation of SIRT1 by polyphenols is beneficial for regulation of calorie restriction, oxidative stress, inflammation, cellular senescence, autophagy/apoptosis, autoimmunity, metabolism, adipogenesis, circadian rhythm, skeletal muscle function, mitochondria biogenesis and endothelial dysfunction.	Polyphenols	34-45	sirtuin 1	Homo sapiens	25-30
20450879-5	2010	In this review, we describe the regulation of SIRT1 by dietary polyphenols in various cellular functions in response to environmental and pro-inflammatory stimuli.	Polyphenols	63-74	sirtuin 1	Homo sapiens	46-51
20633629-0	2010	Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2.	Polyphenols	23-34	mitogen activated protein kinase 3	Rattus norvegicus	108-114
20836978-0	2010	[Tea polyphenol inhibits colorectal cancer with microsatellite instability by regulating the expressions of HES1, JAG1, MT2A and MAFA].	Polyphenols	5-15	hes family bHLH transcription factor 1	Homo sapiens	108-112
19855084-1	2010	The goal of this study was to investigate the effect of epicatechin gallate (ECG), a component of green tea polyphenols, on the signal pathway for oxidative stress-induced intracellular reactive oxygen species (ROS) generation and MUC5AC overexpression in normal human nasal epithelial (NHNE) cells.	Polyphenols	108-119	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	231-237
21687829-0	2010	GREEN TEA POLYPHENOLS MEDIATED APOPTOSIS IN INTESTINAL EPITHELIAL CELLS BY A FADD-DEPENDENT PATHWAY.	Polyphenols	10-21	Fas associated via death domain	Homo sapiens	77-81
20458282-2	2010	Resveratrol, a food-derived polyphenol with antitumorigenic properties, can regulate the expression of cytochrome p450 1b1 (Cyp1b1), which may confer chemoresistance in various cancers.	Polyphenols	28-38	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	103-122
20458282-2	2010	Resveratrol, a food-derived polyphenol with antitumorigenic properties, can regulate the expression of cytochrome p450 1b1 (Cyp1b1), which may confer chemoresistance in various cancers.	Polyphenols	28-38	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	124-130
20692173-5	2010	The epicatechin based polyphenols 1 and 2 also showed inhibition of angiogenin-induced angiogenesis, as determined by chorioallantoic membrane (CAM) assay.	Polyphenols	22-33	angiogenin	Homo sapiens	68-78
20508968-3	2010	In this review, we provide an overview of the molecular mechanisms underlying sensitization to TRAIL-induced apoptosis by polyphenols.	Polyphenols	122-133	TNF superfamily member 10	Homo sapiens	95-100
20508968-6	2010	The large variety of polyphenol cellular targets could prove useful in circumventing TRAIL resistance.	Polyphenols	21-31	TNF superfamily member 10	Homo sapiens	85-90
20836978-0	2010	[Tea polyphenol inhibits colorectal cancer with microsatellite instability by regulating the expressions of HES1, JAG1, MT2A and MAFA].	Polyphenols	5-15	jagged canonical Notch ligand 1	Homo sapiens	114-118
20836978-0	2010	[Tea polyphenol inhibits colorectal cancer with microsatellite instability by regulating the expressions of HES1, JAG1, MT2A and MAFA].	Polyphenols	5-15	metallothionein 2A	Homo sapiens	120-124
20836978-0	2010	[Tea polyphenol inhibits colorectal cancer with microsatellite instability by regulating the expressions of HES1, JAG1, MT2A and MAFA].	Polyphenols	5-15	MAF bZIP transcription factor A	Homo sapiens	129-133
20836978-6	2010	The gene expression arrays and quantitative real-time PCR suggested that tea polyphenol inhibited the gene expressions of MT2A, MAFA, HES1 and JAG1 nearly two-fold over controls.	Polyphenols	77-87	metallothionein 2A	Homo sapiens	122-126
20836978-6	2010	The gene expression arrays and quantitative real-time PCR suggested that tea polyphenol inhibited the gene expressions of MT2A, MAFA, HES1 and JAG1 nearly two-fold over controls.	Polyphenols	77-87	MAF bZIP transcription factor A	Homo sapiens	128-132
20836978-6	2010	The gene expression arrays and quantitative real-time PCR suggested that tea polyphenol inhibited the gene expressions of MT2A, MAFA, HES1 and JAG1 nearly two-fold over controls.	Polyphenols	77-87	hes family bHLH transcription factor 1	Homo sapiens	134-138
20836978-6	2010	The gene expression arrays and quantitative real-time PCR suggested that tea polyphenol inhibited the gene expressions of MT2A, MAFA, HES1 and JAG1 nearly two-fold over controls.	Polyphenols	77-87	jagged canonical Notch ligand 1	Homo sapiens	143-147
20836978-7	2010	It was also found that tea polyphenol inhibited the BAX and p38 genes with a more than two-fold difference but did not significantly inhibit the nuclear factor-kappaB pathway.	Polyphenols	27-37	BCL2 associated X, apoptosis regulator	Homo sapiens	52-55
20836978-7	2010	It was also found that tea polyphenol inhibited the BAX and p38 genes with a more than two-fold difference but did not significantly inhibit the nuclear factor-kappaB pathway.	Polyphenols	27-37	mitogen-activated protein kinase 14	Homo sapiens	60-63
20836978-9	2010	Tea polyphenol inhibited the gene expressions of HES1, JAG1, MT2A and MAFA, up-regulated the gene expression of BAX and down-regulated that of P38.	Polyphenols	4-14	hes family bHLH transcription factor 1	Homo sapiens	49-53
20836978-9	2010	Tea polyphenol inhibited the gene expressions of HES1, JAG1, MT2A and MAFA, up-regulated the gene expression of BAX and down-regulated that of P38.	Polyphenols	4-14	jagged canonical Notch ligand 1	Homo sapiens	55-59
20836978-9	2010	Tea polyphenol inhibited the gene expressions of HES1, JAG1, MT2A and MAFA, up-regulated the gene expression of BAX and down-regulated that of P38.	Polyphenols	4-14	metallothionein 2A	Homo sapiens	61-65
20836978-9	2010	Tea polyphenol inhibited the gene expressions of HES1, JAG1, MT2A and MAFA, up-regulated the gene expression of BAX and down-regulated that of P38.	Polyphenols	4-14	MAF bZIP transcription factor A	Homo sapiens	70-74
20836978-9	2010	Tea polyphenol inhibited the gene expressions of HES1, JAG1, MT2A and MAFA, up-regulated the gene expression of BAX and down-regulated that of P38.	Polyphenols	4-14	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
20836978-9	2010	Tea polyphenol inhibited the gene expressions of HES1, JAG1, MT2A and MAFA, up-regulated the gene expression of BAX and down-regulated that of P38.	Polyphenols	4-14	mitogen-activated protein kinase 14	Homo sapiens	143-146
20700524-3	2010	The present study sought to determine whether (-)-epigallocatechin-3-gallate (EGCG), a common tea polyphenol, can serve as a naturally-occurring COMT inhibitor that also possesses neuroprotective actions.	Polyphenols	98-108	catechol-O-methyltransferase	Homo sapiens	145-149
20449727-2	2010	In addition, there is a growing list of natural compounds, mainly plant polyphenols that can modulate AhR function and downstream signaling with quite unknown consequences for cellular function.	Polyphenols	72-83	aryl hydrocarbon receptor	Homo sapiens	102-105
20584749-0	2010	Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target.	Polyphenols	29-39	nuclear factor kappa B subunit 1	Homo sapiens	72-83
20445555-9	2010	Further studies indicate that PKC-delta is required for calcium and green tea polyphenol-dependent regulation of end responses.	Polyphenols	78-88	protein kinase C delta	Homo sapiens	30-39
19517063-0	2010	Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
19517063-0	2010	Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice.	Polyphenols	4-15	prostaglandin-endoperoxide synthase 2	Mus musculus	24-40
19517063-0	2010	Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice.	Polyphenols	4-15	thymoma viral proto-oncogene 1	Mus musculus	103-106
19517063-3	2010	Tea (Camellia sinensis) and its bioactive polyphenols have been associated with prevention of human cancer for several organs.	Polyphenols	42-53	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
19517063-4	2010	Thus, intake of tea polyphenols seems to be a viable mean to control lung cancer burden.	Polyphenols	20-31	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	16-19
19517063-6	2010	RESULTS: Chemopreventive potential of tea polyphenols, was recorded as evident by, low incidence of alveologenic tumors in lungs of animals at tested doses (0.1% and 0.2% of both GTP and BTP) when compared with DEN (20 mg/kg b wt) treated animals.	Polyphenols	42-53	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	38-41
20528578-0	2010	The synthetic polyphenol tert-butyl-bisphenol inhibits myoglobin-induced dysfunction in cultured kidney epithelial cells.	Polyphenols	14-24	myoglobin	Canis lupus familiaris	55-64
20507262-1	2010	OBJECTIVE: To investigate the effects of resveratrol, a naturally occurring polyphenol, on the expression of vascular endothelial growth factor (VEGF) in human gingival fibroblast culture in response to vesicles and outer membrane proteins from periodontopathic bacteria.	Polyphenols	76-86	vascular endothelial growth factor A	Homo sapiens	145-149
20623641-10	2010	Together, these results suggest that green tea polyphenols with the R1 galloyl group prevent activation of the c-Met receptor by altering the structure or function of lipid rafts.	Polyphenols	47-58	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	111-116
20596647-0	2010	Inhibition of catechol-Omicron-methyltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG.	Polyphenols	135-145	catechol-O-methyltransferase	Homo sapiens	14-48
20596647-6	2010	This study supplements the previous findings that methylated (-)-EGCG is less bioactive and supports the notion that COMT inhibition may increase the anti-cancer properties of tea polyphenols and the combination may serve as a novel approach or supplemental treatment for breast cancer chemotherapy.	Polyphenols	180-191	catechol-O-methyltransferase	Homo sapiens	117-121
20565072-4	2010	A recent report showed that epigallocatechin 3-gallate (EGCG), the major polyphenol component of green tea, binds to TTR and suppresses TTR amyloid fibril formation.	Polyphenols	73-83	transthyretin	Homo sapiens	117-120
20548792-0	2010	Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor.	Polyphenols	51-61	ribosomal protein SA	Mus musculus	122-145
20461739-0	2010	Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts.	Polyphenols	4-15	interleukin 6	Homo sapiens	24-28
20461739-0	2010	Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts.	Polyphenols	4-15	TNF superfamily member 14	Homo sapiens	43-79
20548792-0	2010	Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor.	Polyphenols	94-104	ribosomal protein SA	Mus musculus	122-145
19856314-0	2010	Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells.	Polyphenols	61-72	glutathione S-transferase pi 1	Homo sapiens	99-104
20429690-2	2010	Resveratrol is a natural polyphenol that activates SIRT1, a novel cardioprotective and longevity factor having NAD(+)-dependent histone deacetylase activity.	Polyphenols	25-35	sirtuin 1	Rattus norvegicus	51-56
20506578-0	2010	Synergistic effects of tea polyphenols and ascorbic acid on human lung adenocarcinoma SPC-A-1 cells.	Polyphenols	27-38	proline rich protein gene cluster	Homo sapiens	86-89
20132809-8	2010	Three weeks after DSS removal, the polyphenol caused substantial reductions of the rise of pro-inflammatory cytokines, TNF-alpha and IL-1beta and an increase of the anti-inflammatory cytokine IL-10.	Polyphenols	35-45	tumor necrosis factor	Mus musculus	119-128
20441222-6	2010	By using in silico ligand docking and an array of in vitro assays, we have identified submicromolar (600 nM) N1L antagonists belonging to the family of polyphenols.	Polyphenols	152-163	putative virulence factor	Vaccinia virus	109-112
20441222-8	2010	We have also identified the natural polyphenol resveratrol as a moderate N1L inhibitor.	Polyphenols	36-46	putative virulence factor	Vaccinia virus	73-76
20349911-3	2010	In the present investigation, we demonstrated that 12-o-tetradecanoylphobor-13-acetate (TPA) and constitutively activated PKC alpha significantly increased migration and invasion of HepG2 cells, while treatment with water or polyphenol extracts of SN (SNWE or SNPE) attenuated TPA-induced migration and invasion.	Polyphenols	225-235	protein kinase C alpha	Homo sapiens	122-131
20349911-3	2010	In the present investigation, we demonstrated that 12-o-tetradecanoylphobor-13-acetate (TPA) and constitutively activated PKC alpha significantly increased migration and invasion of HepG2 cells, while treatment with water or polyphenol extracts of SN (SNWE or SNPE) attenuated TPA-induced migration and invasion.	Polyphenols	225-235	plasminogen activator, tissue type	Homo sapiens	88-91
20349911-0	2010	Polyphenol-rich extracts from Solanum nigrum attenuated PKC alpha-mediated migration and invasion of hepatocellular carcinoma cells.	Polyphenols	0-10	protein kinase C alpha	Homo sapiens	56-65
20132809-8	2010	Three weeks after DSS removal, the polyphenol caused substantial reductions of the rise of pro-inflammatory cytokines, TNF-alpha and IL-1beta and an increase of the anti-inflammatory cytokine IL-10.	Polyphenols	35-45	interleukin 1 beta	Mus musculus	133-141
20132809-8	2010	Three weeks after DSS removal, the polyphenol caused substantial reductions of the rise of pro-inflammatory cytokines, TNF-alpha and IL-1beta and an increase of the anti-inflammatory cytokine IL-10.	Polyphenols	35-45	interleukin 10	Mus musculus	192-197
20224869-5	2010	The polyphenol-induced NO formation is due to the redox-sensitive activation of the phosphatidylinositol3-kinase/Akt pathway leading to endothelial NO synthase (eNOS) activation subsequent to its phosphorylation on Ser 1177.	Polyphenols	4-14	AKT serine/threonine kinase 1	Homo sapiens	113-116
20438634-0	2010	Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols.	Polyphenols	108-119	ATP binding cassette subfamily B member 1	Homo sapiens	35-49
20224869-6	2010	Besides the phosphatidylinositol3-kinase/Akt pathway, polyphenols have also been shown to activate eNOS by increasing the intracellular free calcium concentration and by activating estrogen receptors in endothelial cells.	Polyphenols	54-65	AKT serine/threonine kinase 1	Homo sapiens	41-44
20707208-0	2010	[Protective activity of different concentration of tea polyphenols and its major compound EGCG against whole body irradiation-induced injury in mice].	Polyphenols	55-66	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	51-54
20707208-1	2010	OBJECTIVE: To evaluate the different concentrate of tea polyphenols (TP) and its compound for irradiation-protection and investigate its mechanism.	Polyphenols	56-67	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	52-55
20093625-9	2010	CONCLUSIONS: Specific dietary polyphenols, in particular quercetin and theaflavin, may attenuate atherosclerosis in ApoE(-/-) gene-knockout mice by alleviating inflammation, improving NO bioavailability, and inducing heme oxygenase-1.	Polyphenols	30-41	apolipoprotein E	Mus musculus	116-120
20385841-2	2010	Recently, we demonstrated that the polyphenol (-)-epi-gallocatechine gallate (EGCG) inhibits alpha-synuclein and amyloid-beta fibrillogenesis.	Polyphenols	35-45	synuclein alpha	Homo sapiens	93-108
20093625-0	2010	Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction.	Polyphenols	17-28	apolipoprotein E	Mus musculus	58-74
20093625-9	2010	CONCLUSIONS: Specific dietary polyphenols, in particular quercetin and theaflavin, may attenuate atherosclerosis in ApoE(-/-) gene-knockout mice by alleviating inflammation, improving NO bioavailability, and inducing heme oxygenase-1.	Polyphenols	30-41	heme oxygenase 1	Mus musculus	217-233
20080969-2	2010	The natural polyphenol resveratrol promotes anti-aging pathways via the activation of several metabolic sensors, including the AMP-activated protein kinase (AMPK).	Polyphenols	12-22	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	157-161
20480025-3	2010	In animal models and a limited number of human studies carried out so far, polyphenols and foods or beverages rich in polyphenols have attenuated postprandial glycemic responses and fasting hyperglycemia, and improved acute insulin secretion and insulin sensitivity.	Polyphenols	75-86	insulin	Homo sapiens	224-231
20480025-3	2010	In animal models and a limited number of human studies carried out so far, polyphenols and foods or beverages rich in polyphenols have attenuated postprandial glycemic responses and fasting hyperglycemia, and improved acute insulin secretion and insulin sensitivity.	Polyphenols	118-129	insulin	Homo sapiens	224-231
19762215-0	2010	Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients.	Polyphenols	18-29	paraoxonase 1	Homo sapiens	51-64
19762215-2	2010	Because diabetes is associated with increased oxidative stress, we hypothesized that a labeled recombinant PON1 (rePON1) would detect differences in HDL capacity to bind PON1 under specific experimental conditions, such as oxidation, addition of polyphenols, or in vivo dosing of diabetic patients with polyphenols.	Polyphenols	246-257	paraoxonase 1	Homo sapiens	107-111
19762215-2	2010	Because diabetes is associated with increased oxidative stress, we hypothesized that a labeled recombinant PON1 (rePON1) would detect differences in HDL capacity to bind PON1 under specific experimental conditions, such as oxidation, addition of polyphenols, or in vivo dosing of diabetic patients with polyphenols.	Polyphenols	246-257	paraoxonase 1	Homo sapiens	115-119
19762215-2	2010	Because diabetes is associated with increased oxidative stress, we hypothesized that a labeled recombinant PON1 (rePON1) would detect differences in HDL capacity to bind PON1 under specific experimental conditions, such as oxidation, addition of polyphenols, or in vivo dosing of diabetic patients with polyphenols.	Polyphenols	303-314	paraoxonase 1	Homo sapiens	107-111
19762215-2	2010	Because diabetes is associated with increased oxidative stress, we hypothesized that a labeled recombinant PON1 (rePON1) would detect differences in HDL capacity to bind PON1 under specific experimental conditions, such as oxidation, addition of polyphenols, or in vivo dosing of diabetic patients with polyphenols.	Polyphenols	303-314	paraoxonase 1	Homo sapiens	115-119
20336028-3	2010	Polyphenols can modulate TRAIL-mediated apoptosis in cancer cells.	Polyphenols	0-11	TNF superfamily member 10	Homo sapiens	25-30
20338103-0	2010	Dietary polyphenols affect MUC5AC expression and ciliary movement in respiratory cells and nasal mucosa.	Polyphenols	8-19	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	27-33
20061381-4	2010	Five potential PAI-1 inhibitors were identified, and all were polyphenolic compounds including two related, naturally occurring plant polyphenols that were structurally similar to compounds previously shown to provide cardiovascular benefit in vivo.	Polyphenols	134-145	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	15-20
20061381-10	2010	These data describe a novel family of high affinity PAI-1-inactivating compounds with improved characteristics and in vivo efficacy, and suggest that the known cardiovascular benefits of dietary polyphenols may derive in part from their inactivation of PAI-1.	Polyphenols	195-206	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	52-57
20061381-10	2010	These data describe a novel family of high affinity PAI-1-inactivating compounds with improved characteristics and in vivo efficacy, and suggest that the known cardiovascular benefits of dietary polyphenols may derive in part from their inactivation of PAI-1.	Polyphenols	195-206	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	253-258
20338103-8	2010	RESULTS: Minimal inhibitory concentration (MIC) of MUC5AC expression of each polyphenol was found as follows: [6]-gingerol, 1 microM; EGCG, 20 microM; quercetin, 40 microM; and curcumin, 10 microM.	Polyphenols	77-87	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	51-57
20185318-3	2010	All mammalian isozymes of human (h) or murine (m) origin hCA I-hCA XII, mCA XIII and hCA XIV were inhibited in the low micromolar or submicromolar range by these (poly)phenols (K(I)s in the range of 0.87-7.79 microM).	Polyphenols	162-175	carbonic anhydrase 13	Mus musculus	72-80
20148537-1	2010	We report the complexation of bovine serum albumin (BSA) with resveratrol, genistein, and curcumin, at physiological conditions, using constant protein concentration and various polyphenol contents.	Polyphenols	178-188	albumin	Homo sapiens	37-50
20117080-1	2010	Several rich sources of polyphenols stimulate the endothelial formation of nitric oxide (NO), a potent vasoprotecting factor, via the redox-sensitive activation of the PI3-kinase/Akt pathway leading to the phosphorylation of endothelial NO synthase (eNOS).	Polyphenols	24-35	AKT serine/threonine kinase 1	Homo sapiens	179-182
20074931-0	2010	Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1.	Polyphenols	9-20	tumor protein p73	Homo sapiens	145-148
20074931-0	2010	Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1.	Polyphenols	9-20	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	172-177
20099825-2	2010	This study tested a variety of polyphenols for their ability to modulate CAR activity.	Polyphenols	31-42	nuclear receptor subfamily 1 group I member 3	Homo sapiens	73-76
20070102-0	2010	Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of cyclin-dependent kinase.	Polyphenols	0-10	tumor protein p53	Homo sapiens	120-123
20097158-4	2010	Furthermore, both polyphenols intervene to prevent the formation of PDI-resistant polymeric misfolded protein forms that accumulate upon exposure to oxidative stress.	Polyphenols	18-29	prolyl 4-hydroxylase subunit beta	Homo sapiens	68-71
20056361-8	2010	Calorie restriction, polyphenols such as resveratrol, rapamycin, spermidine and angiotensin I converting enzyme inhibitor, are able to increase lifespan by modulation of branches of the longevity pathways.	Polyphenols	21-32	angiotensin I converting enzyme	Homo sapiens	80-111
20045338-0	2010	Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs.	Polyphenols	112-122	catechol-O-methyltransferase	Homo sapiens	61-89
20298168-6	2010	Polyphenols have also been shown to possess other anticancer properties such as specific cell-signaling actions that may stimulate the activity of the regulatory protein SIRT1.	Polyphenols	0-11	sirtuin 1	Homo sapiens	170-175
19895818-2	2010	Previous analyses have revealed that several polyphenols inhibit alpha-synuclein assembly with low micromolar IC(50) values, and that SDS-stable, noncytotoxic soluble alpha-synuclein oligomers are formed in their presence.	Polyphenols	45-56	synuclein alpha	Homo sapiens	65-80
20423306-5	2010	The activity of cancer inhibition generated from dietary polyphenols is associated with gene reactivation through demethylation in the promoters of methylation-silenced genes such as p16INK4a and retinoic acid receptor beta.	Polyphenols	57-68	cyclin dependent kinase inhibitor 2A	Homo sapiens	183-191
20955562-13	2010	In addition, we also demonstrate that polyphenol rich PE inhibited the IL-1beta-induced activation of MKK3, p38alpha-MAPK isoform and DNA binding activity of the transcription factor RUNX-2.	Polyphenols	38-48	interleukin 1 beta	Homo sapiens	71-79
20955562-13	2010	In addition, we also demonstrate that polyphenol rich PE inhibited the IL-1beta-induced activation of MKK3, p38alpha-MAPK isoform and DNA binding activity of the transcription factor RUNX-2.	Polyphenols	38-48	mitogen-activated protein kinase kinase 3	Homo sapiens	102-106
20955562-13	2010	In addition, we also demonstrate that polyphenol rich PE inhibited the IL-1beta-induced activation of MKK3, p38alpha-MAPK isoform and DNA binding activity of the transcription factor RUNX-2.	Polyphenols	38-48	mitogen-activated protein kinase 14	Homo sapiens	108-116
20955562-13	2010	In addition, we also demonstrate that polyphenol rich PE inhibited the IL-1beta-induced activation of MKK3, p38alpha-MAPK isoform and DNA binding activity of the transcription factor RUNX-2.	Polyphenols	38-48	RUNX family transcription factor 2	Homo sapiens	183-189
19941471-11	2010	Natural products continue to provide structurally complex, but highly original lead structures for drug discovery programs: polyphenols, quinones, and terpenoids showed to affect the Trx/TrxR system at different levels.	Polyphenols	124-135	thioredoxin	Homo sapiens	183-186
19941471-11	2010	Natural products continue to provide structurally complex, but highly original lead structures for drug discovery programs: polyphenols, quinones, and terpenoids showed to affect the Trx/TrxR system at different levels.	Polyphenols	124-135	peroxiredoxin 5	Homo sapiens	187-191
19941471-13	2010	Among polyphenols, curcumin and some flavonoids such as myricetin and quercetin, have been identified as potential anticancer agents with a mechanism of action that may be mediated by the Trx system.	Polyphenols	6-17	thioredoxin	Homo sapiens	188-191
20423306-5	2010	The activity of cancer inhibition generated from dietary polyphenols is associated with gene reactivation through demethylation in the promoters of methylation-silenced genes such as p16INK4a and retinoic acid receptor beta.	Polyphenols	57-68	retinoic acid receptor beta	Homo sapiens	196-223
20423306-6	2010	The effects of dietary polyphenols such as EGCG on DNMTs appear to have their direct inhibition by interaction with the catalytic site of the DNMT1 molecule, and may also influence methylation status indirectly through metabolic effects associated with energy metabolism.	Polyphenols	23-34	DNA methyltransferase 1	Homo sapiens	142-147
21525764-12	2010	As polyphenols have great potential to induce HO-1 expression, they may play an important role for future therapeutic strategies to protect liver from oxidative stress-dependent damage observed during chronic alcohol consumption.	Polyphenols	3-14	heme oxygenase 1	Homo sapiens	46-50
19883715-0	2010	Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity.	Polyphenols	22-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-70
19883715-3	2010	In this study, we systematically evaluated the inhibitory effects of 60 polyphenols and related compounds on human cytochrome P450 (CYP) 3A4 and CYP2C9 activity by in vitro assay to investigate whether some polyphenols induce drug interactions.	Polyphenols	72-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	115-140
19883715-3	2010	In this study, we systematically evaluated the inhibitory effects of 60 polyphenols and related compounds on human cytochrome P450 (CYP) 3A4 and CYP2C9 activity by in vitro assay to investigate whether some polyphenols induce drug interactions.	Polyphenols	72-83	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	145-151
20072929-3	2010	Current methods to evaluate the antioxidant potential of polyphenols are based on in vitro assay procedures (TEAC, ORAC, FRAP, DPPH).	Polyphenols	57-68	mechanistic target of rapamycin kinase	Homo sapiens	121-125
21191472-0	2010	Genetic Association Between the COMT Genotype and Urinary Levels of Tea Polyphenols and Their Metabolites among Daily Green Tea Drinkers.	Polyphenols	72-83	catechol-O-methyltransferase	Homo sapiens	32-36
21191472-2	2010	Recent study suggests a greater protective effect of green tea intake on breast cancer risk among women possessing the low-activity associated genotype of the catechol-O-methyltransferase (COMT), which may modulate the metabolism and excretion of tea polyphenols through urine.	Polyphenols	251-262	catechol-O-methyltransferase	Homo sapiens	159-187
21191472-2	2010	Recent study suggests a greater protective effect of green tea intake on breast cancer risk among women possessing the low-activity associated genotype of the catechol-O-methyltransferase (COMT), which may modulate the metabolism and excretion of tea polyphenols through urine.	Polyphenols	251-262	catechol-O-methyltransferase	Homo sapiens	189-193
21191472-3	2010	To determine the effect of COMT genotype on urinary excretion of tea polyphenol metabolites of daily green tea drinkers, a cross-sectional analysis was performed within the Shanghai Cohort Study, a population-based, prospective investigation of diet and cancer in 18,244men.	Polyphenols	69-79	catechol-O-methyltransferase	Homo sapiens	27-31
21191472-7	2010	Men possessing the homozygous low-activity associated COMT genotype (LL) exhibited statistically significantly lower urinary levels of individual as well as all of the five tea polyphenol metabolites under study relative to individuals possessing the wild type high-activity associated COMT genotype (HH)or the heterozygous variant genotype (HL).	Polyphenols	177-187	catechol-O-methyltransferase	Homo sapiens	54-58
21191472-9	2010	The present study demonstrated that men carrying low-activity associated COMT genotype excreted less tea polyphenols from urine, which suggests that they may retain more tea polyphenols in their bodies and derive greater health benefits from green tea intake.	Polyphenols	105-116	catechol-O-methyltransferase	Homo sapiens	73-77
21191472-9	2010	The present study demonstrated that men carrying low-activity associated COMT genotype excreted less tea polyphenols from urine, which suggests that they may retain more tea polyphenols in their bodies and derive greater health benefits from green tea intake.	Polyphenols	174-185	catechol-O-methyltransferase	Homo sapiens	73-77
20528747-0	2010	Black tea polyphenol (theaflavin) downregulates MMP-2 in human melanoma cell line A375 by involving multiple regulatory molecules.	Polyphenols	10-20	matrix metallopeptidase 2	Homo sapiens	48-53
19828881-3	2010	However, a multitude of plant-derived constituents, e.g., polyphenols that exhibit beneficial properties, have also been described as ligands for the AHR.	Polyphenols	58-69	aryl hydrocarbon receptor	Homo sapiens	150-153
19843076-1	2009	Resveratrol is a plant polyphenol capable of exerting beneficial metabolic effects which are thought to be mediated in large by the activation of the NAD(+)-dependent protein deacetylase SIRT1.	Polyphenols	23-33	sirtuin 1	Sus scrofa	187-192
20049322-0	2010	Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium.	Polyphenols	52-63	estrogen receptor 1 (alpha)	Mus musculus	0-23
20049322-3	2010	We hypothesized that alpha isoform of estrogen receptor (ERalpha) could be involved in the transduction of the vascular benefits of polyphenols.	Polyphenols	132-143	estrogen receptor 1 (alpha)	Mus musculus	57-64
20049322-5	2010	Indeed, Provinols, delphinidin and ERalpha agonists, 17-beta-estradiol and PPT, are able to induce endothelial vasodilatation in aorta from ERalpha Wild-Type but not from Knock-Out mice, by activation of nitric oxide (NO) pathway in endothelial cells.	Polyphenols	8-17	palmitoyl-protein thioesterase 1	Mus musculus	75-78
20049322-5	2010	Indeed, Provinols, delphinidin and ERalpha agonists, 17-beta-estradiol and PPT, are able to induce endothelial vasodilatation in aorta from ERalpha Wild-Type but not from Knock-Out mice, by activation of nitric oxide (NO) pathway in endothelial cells.	Polyphenols	8-17	estrogen receptor 1 (alpha)	Mus musculus	140-147
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	Polyphenols	78-87	estrogen receptor 1 (alpha)	Mus musculus	34-41
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	Polyphenols	78-87	Rous sarcoma oncogene	Mus musculus	128-131
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	Polyphenols	78-87	mitogen-activated protein kinase 3	Mus musculus	133-140
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	Polyphenols	78-87	nitric oxide synthase 3, endothelial cell	Mus musculus	142-146
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	Polyphenols	78-87	caveolin 1, caveolae protein	Mus musculus	148-158
20049322-8	2010	Most interestingly, the ability of short term oral administration of Provinols to decrease response to serotonin and to enhance sensitivity of the endothelium-dependent relaxation to acetylcholine, associated with concomitant increased NO production and decreased superoxide anions, was completely blunted in ERalpha deficient mice.	Polyphenols	69-78	estrogen receptor 1 (alpha)	Mus musculus	309-316
20049322-9	2010	CONCLUSIONS/SIGNIFICANCE: This study provides evidence that red wine polyphenols, especially delphinidin, exert their endothelial benefits via ERalpha activation.	Polyphenols	69-80	estrogen receptor 1 (alpha)	Mus musculus	143-150
20008854-2	2009	The natural polyphenol (-)-epigallocatechin-3-gallate blocks in vitro FASN activity and leads to apoptosis in breast cancer cells without any effects on carnitine palmitoyltransferase-1 (CPT-1) activity, and in vivo, does not decrease body weight.	Polyphenols	12-22	fatty acid synthase	Homo sapiens	70-74
19640694-3	2010	This study examines the regulation of uPA and PAI-1 by a natural polyphenol-rich compound, grape seed extract (GSE).	Polyphenols	65-75	plasminogen activator, urokinase	Homo sapiens	38-41
19640694-3	2010	This study examines the regulation of uPA and PAI-1 by a natural polyphenol-rich compound, grape seed extract (GSE).	Polyphenols	65-75	serpin family E member 1	Homo sapiens	46-51
21189167-1	2010	The work is focused on clarifying the impact of diabetes and natural plant polyphenols contained in Pycnogenol  (PYC) on the activity and synthesis of Cu/Zn-SOD and synthesis of nNOS and eNOS in the cerebellum and cerebral cortex in rats with induced diabetes.	Polyphenols	75-86	superoxide dismutase 1	Rattus norvegicus	151-160
21189167-1	2010	The work is focused on clarifying the impact of diabetes and natural plant polyphenols contained in Pycnogenol  (PYC) on the activity and synthesis of Cu/Zn-SOD and synthesis of nNOS and eNOS in the cerebellum and cerebral cortex in rats with induced diabetes.	Polyphenols	75-86	nitric oxide synthase 1	Rattus norvegicus	178-182
19878655-5	2009	EA promoted Abeta fibril formation and significant oligomer loss, contrary to previous results that polyphenols inhibited Abeta aggregation.	Polyphenols	100-111	amyloid beta precursor protein	Homo sapiens	122-127
20054477-0	2009	Binding of natural and synthetic polyphenols to human dihydrofolate reductase.	Polyphenols	33-44	dihydrofolate reductase	Homo sapiens	54-77
19195865-0	2009	Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells.	Polyphenols	10-21	caveolin 1	Rattus norvegicus	36-46
19195865-0	2009	Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells.	Polyphenols	10-21	mitogen activated protein kinase 3	Rattus norvegicus	62-68
19195865-0	2009	Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells.	Polyphenols	10-21	mitogen activated protein kinase 14	Rattus norvegicus	73-80
19195865-3	2009	In this study, we investigated the effects of green tea polyphenols (GTPs) on endothelial Cav-1 expression and phosphorylation in vitro.	Polyphenols	56-67	caveolin 1	Rattus norvegicus	90-95
19672210-1	2009	OBJECTIVE: Green tea polyphenols (GTPs) are naturally occurring antioxidants acting through pathways that include reactive oxygen species and nuclear factor kappa B (NF-kappaB).	Polyphenols	21-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-164
19632288-1	2009	Many plant-derived compounds, including polyphenols, are able to affect the function of MDR-1/P-glycoprotein (P-gp ABCB1) multidrug transporter, leading to potential herb-drug interactions.	Polyphenols	40-51	phosphoglycolate phosphatase	Homo sapiens	110-114
19632288-8	2009	Our results demonstrate, for the first time, that M. indica and polyphenols derived may affect the activity of the multidrug transporter P-gp ABCB1, suggesting the possibility of herb-drug interactions to be explored in depth.	Polyphenols	64-75	phosphoglycolate phosphatase	Homo sapiens	137-141
19672210-1	2009	OBJECTIVE: Green tea polyphenols (GTPs) are naturally occurring antioxidants acting through pathways that include reactive oxygen species and nuclear factor kappa B (NF-kappaB).	Polyphenols	21-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	166-175
19670229-8	2009	Polyphenol treatments decreased cell proliferation and insulin-like growth factor-1 (IGF-1) protein expression in the prostate.	Polyphenols	0-10	insulin-like growth factor 1	Rattus norvegicus	55-83
19670229-8	2009	Polyphenol treatments decreased cell proliferation and insulin-like growth factor-1 (IGF-1) protein expression in the prostate.	Polyphenols	0-10	insulin-like growth factor 1	Rattus norvegicus	85-90
19450372-10	2009	Pure polyphenols, particularly quercetin, also reduced NADPH oxidase subunit expression, especially p47phox, in all cell types tested.	Polyphenols	5-16	neutrophil cytosolic factor 1	Homo sapiens	100-107
19753602-0	2009	Impact of apple polyphenols on GSTT2 gene expression, subsequent protection of DNA and modulation of proliferation using LT97 human colon adenoma cells.	Polyphenols	16-27	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	31-36
19713834-0	2009	Green tea polyphenols inhibit plasminogen activator inhibitor-1 expression and secretion in endothelial cells.	Polyphenols	10-21	serpin family E member 1	Bos taurus	30-63
19713834-4	2009	To determine the effect and molecular mechanism of green tea polyphenols (GTPs) on the regulation of PAI-1 expression in endothelial cells, bovine aortic endothelial cells were incubated with GTPs, and PAI-1 expressions were measured by western blot and enzyme-linked immunosorbent assay, respectively.	Polyphenols	61-72	serpin family E member 1	Bos taurus	101-106
19818314-0	2009	AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols.	Polyphenols	98-109	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-28
19743802-8	2009	To examine the reactivity of the catechol type polyphenols, such as flavonoids, to endogenous beta-actin, RL34 cells were coexposed to Bio-DPA and the flavonoids quercetin, (-)-epicatechin, and (-)-epicatechin gallate.	Polyphenols	47-58	POTE ankyrin domain family member F	Homo sapiens	94-104
19743802-10	2009	These results indicate that beta-actin is one of the major targets of protein modification by catechol type polyphenols and that Bio-DPA is an useful probe for understanding the redox regulation by dietary polyphenols.	Polyphenols	108-119	POTE ankyrin domain family member F	Homo sapiens	28-38
19743802-10	2009	These results indicate that beta-actin is one of the major targets of protein modification by catechol type polyphenols and that Bio-DPA is an useful probe for understanding the redox regulation by dietary polyphenols.	Polyphenols	206-217	POTE ankyrin domain family member F	Homo sapiens	28-38
19743802-11	2009	Furthermore, Keap1, a scaffold protein to the actin cytoskeleton controlling cytoprotective enzyme genes, was also identified as another plausible target of the catechol type polyphenols by oxidative modification of the intracellular sulfhydryls.	Polyphenols	175-186	kelch like ECH associated protein 1	Homo sapiens	13-18
19764065-10	2009	Our results provide confirmation that T84 cells could be used as model system to simulate the intestinal mucosa, and that polyphenols are able to increase the TER of C10-treated and -untreated T84 monolayers.	Polyphenols	122-133	homeobox C10	Homo sapiens	166-169
19753610-0	2009	GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage.	Polyphenols	40-51	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	0-5
19753610-3	2009	In addition to an antioxidant and antiproliferative activity, apple polyphenols have been shown to elevate expression of the phase II gene glutathione S-transferase T2 (GSTT2) in colon epithelial cells.	Polyphenols	68-79	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	169-174
19753610-8	2009	Our results causally link GSTT2 levels with protection from genotoxic stress, and provide evidence that the antigenotoxic effects of apple polyphenols in vitro are at least in part due to an induction of GSTT2 expression.	Polyphenols	139-150	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	204-209
19764065-6	2009	Exposure to C10 induced a decrease in TER that was reversible by incubation with polyphenols.	Polyphenols	81-92	homeobox C10	Homo sapiens	12-15
19502006-7	2009	The inhibition of nuclear factor-kappaB activation and subsequent expression of inducible nitric oxide synthase, adhesion molecules, and tumor necrosis factor-alpha by polyphenols is operative in ameliorating the sequelae of sepsis.	Polyphenols	168-179	tumor necrosis factor	Homo sapiens	137-164
19254115-0	2009	Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts.	Polyphenols	0-10	elastin	Homo sapiens	30-37
19616561-1	2009	The polyphenol (-)-epigallocatechin-3-gallate (EGCG) has recently attracted much research interest in the field of protein-misfolding diseases because of its potent anti-amyloid activity against amyloid-beta, alpha-synuclein and huntingtin, the amyloid-fibril-forming proteins involved in Alzheimer"s, Parkinson"s and Huntington"s diseases, respectively.	Polyphenols	4-14	synuclein alpha	Homo sapiens	209-224
19616561-1	2009	The polyphenol (-)-epigallocatechin-3-gallate (EGCG) has recently attracted much research interest in the field of protein-misfolding diseases because of its potent anti-amyloid activity against amyloid-beta, alpha-synuclein and huntingtin, the amyloid-fibril-forming proteins involved in Alzheimer"s, Parkinson"s and Huntington"s diseases, respectively.	Polyphenols	4-14	huntingtin	Homo sapiens	229-239
19722703-8	2009	Concentration-dependent correlations between enhanced NO level and endothelial nitric oxide synthase (eNOS) expression were demonstrated for the three polyphenols tested (resveratrol, ECg, and EGCg).	Polyphenols	151-162	nitric oxide synthase 3	Homo sapiens	67-100
19496785-5	2009	Western blot analyses showed that resveratrol (10 microM) and quercetin (25 microM) caused a reduction in phosphorylation of Akt, but this reduction was not sufficient by itself to mediate the effects of these polyphenols.	Polyphenols	210-221	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
19481143-7	2009	Next, marked down-regulation of protein kinase C beta-1 (PKC beta-1) and phosphorylated mitogen-activated protein kinase (p-MAPK) expression suggest that observed inhibitory effect of the polyphenol-rich SMAE on the Hcy-induced growth of rat A10 cells was realized via the PKC/p44/42 MAPK-dependent pathway.	Polyphenols	188-198	protein kinase C, beta	Rattus norvegicus	32-55
19393773-7	2009	In conclusion, CGA suppresses LPS-induced COX-2 expression via attenuating the activation of NF-kappaB and JNK/AP-1 signaling pathways suggesting that CGA, the polyphenol compound in our food, could exert anti-inflammatory effects through inhibiting PGE(2) production.	Polyphenols	160-170	cytochrome c oxidase II, mitochondrial	Mus musculus	42-47
19652885-7	2009	Molecular modelling studies, performed by in silico docking the polyphenols into the crystal structure of COX-1, suggested that all compounds form stable complexes into the COX-1 channel, with slightly different but functionally relevant interaction geometries.	Polyphenols	64-75	prostaglandin-endoperoxide synthase 1	Mus musculus	106-111
19652885-7	2009	Molecular modelling studies, performed by in silico docking the polyphenols into the crystal structure of COX-1, suggested that all compounds form stable complexes into the COX-1 channel, with slightly different but functionally relevant interaction geometries.	Polyphenols	64-75	prostaglandin-endoperoxide synthase 1	Mus musculus	173-178
19652885-10	2009	Gallic acid interactions with other polyphenols or aspirin at the level of platelet COX-1 might partly explain the complex, and possibly contrasting, effects of wine and other components of the Mediterranean diet on platelets and on the pharmacologic effect of low-dose aspirin.	Polyphenols	36-47	prostaglandin-endoperoxide synthase 1	Mus musculus	84-89
19625699-3	2009	Experimental studies indicate that grape polyphenols could reduce atherosclerosis by a number of mechanisms, including inhibition of oxidation of LDL and other favorable effects on cellular redox state, improvement of endothelial function, lowering blood pressure, inhibition of platelet aggregation, reducing inflammation, and activating novel proteins that prevent cell senescence, e.g. Sirtuin 1.	Polyphenols	41-52	sirtuin 1	Homo sapiens	389-398
19531491-4	2009	Subsequent studies demonstrated that wild-type and hyperinsulinemia/hyperammonemia forms of GDH are inhibited by the green tea polyphenols, epigallocatechin gallate and epicatechin gallate.	Polyphenols	127-138	glutamate dehydrogenase 1	Homo sapiens	92-95
19542563-0	2009	Solution structure of human cardiac troponin C in complex with the green tea polyphenol, (-)-epigallocatechin 3-gallate.	Polyphenols	77-87	troponin C1, slow skeletal and cardiac type	Homo sapiens	28-46
19722586-6	2009	BTP and TFDG had a similar effect in inhibiting the activity of pancreatic lipase when the total polyphenol amount was adjusted to the same.	Polyphenols	97-107	pancreatic lipase	Rattus norvegicus	64-81
19638461-0	2009	The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells.	Polyphenols	14-24	met proto-oncogene	Mus musculus	76-81
19638461-0	2009	The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells.	Polyphenols	14-24	epidermal growth factor receptor	Mus musculus	86-118
19406951-1	2009	The dietary polyphenol resveratrol (RES) exists as cis- and trans-isomers with known stereospecific and stereoselective glucuronidation at the 3 and 4" positions by distinct UGT1A isoforms.	Polyphenols	12-22	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	174-179
19406223-0	2009	Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549.	Polyphenols	58-69	tumor protein p53	Homo sapiens	93-96
20021964-0	2009	[High glucose and tea polyphenols on expression of matrix metalloproteinase-2 and extracellular matrix metalloproteinase inducer in human umbilical vein endothelial cells].	Polyphenols	22-33	matrix metallopeptidase 2	Homo sapiens	51-77
20021964-0	2009	[High glucose and tea polyphenols on expression of matrix metalloproteinase-2 and extracellular matrix metalloproteinase inducer in human umbilical vein endothelial cells].	Polyphenols	22-33	basigin (Ok blood group)	Homo sapiens	82-128
19481143-7	2009	Next, marked down-regulation of protein kinase C beta-1 (PKC beta-1) and phosphorylated mitogen-activated protein kinase (p-MAPK) expression suggest that observed inhibitory effect of the polyphenol-rich SMAE on the Hcy-induced growth of rat A10 cells was realized via the PKC/p44/42 MAPK-dependent pathway.	Polyphenols	188-198	protein kinase C, beta	Rattus norvegicus	57-67
19481143-7	2009	Next, marked down-regulation of protein kinase C beta-1 (PKC beta-1) and phosphorylated mitogen-activated protein kinase (p-MAPK) expression suggest that observed inhibitory effect of the polyphenol-rich SMAE on the Hcy-induced growth of rat A10 cells was realized via the PKC/p44/42 MAPK-dependent pathway.	Polyphenols	188-198	protein kinase C, beta	Rattus norvegicus	57-60
19481143-7	2009	Next, marked down-regulation of protein kinase C beta-1 (PKC beta-1) and phosphorylated mitogen-activated protein kinase (p-MAPK) expression suggest that observed inhibitory effect of the polyphenol-rich SMAE on the Hcy-induced growth of rat A10 cells was realized via the PKC/p44/42 MAPK-dependent pathway.	Polyphenols	188-198	mitogen activated protein kinase 3	Rattus norvegicus	277-280
19481143-7	2009	Next, marked down-regulation of protein kinase C beta-1 (PKC beta-1) and phosphorylated mitogen-activated protein kinase (p-MAPK) expression suggest that observed inhibitory effect of the polyphenol-rich SMAE on the Hcy-induced growth of rat A10 cells was realized via the PKC/p44/42 MAPK-dependent pathway.	Polyphenols	188-198	mitogen activated protein kinase 3	Rattus norvegicus	124-128
19556852-7	2009	Tea polyphenols treatment along with DMBA exposure resulted in upregulation of p53, and proapoptotic protein Bax, whereas enhanced expression of antiapoptotic proteins, Bcl-2 and survivin by DMBA were downregulated.	Polyphenols	4-15	transformation related protein 53, pseudogene	Mus musculus	79-82
19556852-7	2009	Tea polyphenols treatment along with DMBA exposure resulted in upregulation of p53, and proapoptotic protein Bax, whereas enhanced expression of antiapoptotic proteins, Bcl-2 and survivin by DMBA were downregulated.	Polyphenols	4-15	BCL2-associated X protein	Mus musculus	109-112
19542190-0	2009	Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro.	Polyphenols	4-15	kallikrein related peptidase 3	Homo sapiens	41-92
19556852-7	2009	Tea polyphenols treatment along with DMBA exposure resulted in upregulation of p53, and proapoptotic protein Bax, whereas enhanced expression of antiapoptotic proteins, Bcl-2 and survivin by DMBA were downregulated.	Polyphenols	4-15	B cell leukemia/lymphoma 2	Mus musculus	169-174
19542190-0	2009	Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro.	Polyphenols	4-15	vascular endothelial growth factor A	Homo sapiens	98-132
19556852-7	2009	Tea polyphenols treatment along with DMBA exposure resulted in upregulation of p53, and proapoptotic protein Bax, whereas enhanced expression of antiapoptotic proteins, Bcl-2 and survivin by DMBA were downregulated.	Polyphenols	4-15	baculoviral IAP repeat-containing 5	Mus musculus	179-187
19542190-0	2009	Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro.	Polyphenols	4-15	hepatocyte growth factor	Homo sapiens	68-92
19542190-0	2009	Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro.	Polyphenols	4-15	vascular endothelial growth factor A	Homo sapiens	216-250
19401153-3	2009	The present study investigated the possible inhibitory effects of red wine polyphenols on TNF-alpha-induced upregulation of MMP-9 and on the migratory phenotype of JB6 P+ mouse epidermal (JB6 P+) cells.	Polyphenols	75-86	tumor necrosis factor	Homo sapiens	90-99
19362588-0	2009	Polyphenol cytotoxicity induced by the bacterial toxin pyocyanin: role of NQO1.	Polyphenols	0-10	NAD(P)H quinone dehydrogenase 1	Homo sapiens	74-78
19362588-7	2009	On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Polyphenols	14-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	222-254
19362588-7	2009	On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Polyphenols	14-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	256-260
19375450-0	2009	Inhibition of ATPase activity of Escherichia coli ATP synthase by polyphenols.	Polyphenols	66-77	ATPase	Escherichia coli	14-20
19502746-2	2009	Because of their chemical structure as polyphenols, these compounds can behave as substrates of tyrosinase and peroxidase.	Polyphenols	39-50	tyrosinase	Homo sapiens	96-106
19415680-1	2009	Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2.	Polyphenols	15-25	sirtuin 1	Rattus norvegicus	77-81
19359525-0	2009	The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists.	Polyphenols	12-23	cannabinoid receptor 1	Homo sapiens	78-81
19359525-5	2009	Characteristic of inverse agonists, the polyphenols inhibit basal G-protein activity in membranes prepared from Chinese hamster ovary (CHO)-hCB1 cells or mouse brain that is reversed by a neutral CB1 antagonist.	Polyphenols	40-51	cannabinoid receptor 1	Homo sapiens	140-144
19359525-5	2009	Characteristic of inverse agonists, the polyphenols inhibit basal G-protein activity in membranes prepared from Chinese hamster ovary (CHO)-hCB1 cells or mouse brain that is reversed by a neutral CB1 antagonist.	Polyphenols	40-51	cannabinoid receptor 1 (brain)	Mus musculus	141-144
19359525-7	2009	In intact CHO-hCB1 cells, the polyphenols act as neutral antagonists, producing no effect when tested alone, whereas competitively antagonizing CB1 agonist mediated inhibition of adenylyl cyclase activity.	Polyphenols	30-41	cannabinoid receptor 1	Homo sapiens	14-18
19359525-7	2009	In intact CHO-hCB1 cells, the polyphenols act as neutral antagonists, producing no effect when tested alone, whereas competitively antagonizing CB1 agonist mediated inhibition of adenylyl cyclase activity.	Polyphenols	30-41	cannabinoid receptor 1 (brain)	Mus musculus	15-18
19359525-8	2009	Confirming their neutral antagonist profile in cells, the polyphenols similarly attenuate stimulation of adenylyl cyclase activity produced by a CB1 inverse agonist.	Polyphenols	58-69	cannabinoid receptor 1 (brain)	Mus musculus	145-148
19359525-9	2009	In mice, the polyphenols dose-dependently reverse acute hypothermia produced by a CB1 agonist.	Polyphenols	13-24	cannabinoid receptor 1 (brain)	Mus musculus	82-85
19359525-13	2009	Therefore, these polyphenols and their derivatives might be developed as novel, nontoxic CB1 therapeutics for obesity and/or drug dependence.	Polyphenols	17-28	cannabinoid receptor 1 (brain)	Mus musculus	89-92
19441815-7	2009	The A549 and CH27 cell lines treated with resveratrol, MR-3, and HMDB showed a time-dependent reduction of mitochondrial membrane potential, and the Bax/Bcl-2 ratio increased gradually with a higher concentration of polyphenols.	Polyphenols	216-227	BCL2 associated X, apoptosis regulator	Homo sapiens	149-152
19441815-7	2009	The A549 and CH27 cell lines treated with resveratrol, MR-3, and HMDB showed a time-dependent reduction of mitochondrial membrane potential, and the Bax/Bcl-2 ratio increased gradually with a higher concentration of polyphenols.	Polyphenols	216-227	BCL2 apoptosis regulator	Homo sapiens	153-158
19030989-5	2009	The mechanism of this destabilization could be a dynamic interaction between the polyphenol and the Abeta that could open the hydrophobic zipper and shift the reversible equilibrium "random coil&lt;--&gt;beta-sheet" to the disordered structure.	Polyphenols	81-91	amyloid beta precursor protein	Homo sapiens	100-105
19243669-7	2009	Polyphenols cited in the present review seem to be able to modulate the expression of transcription factors such as runt-related transcription factor-2 (Runx2) and Osterix, NF-kappaB and activator protein-1 (AP-1).	Polyphenols	0-11	RUNX family transcription factor 2	Homo sapiens	116-151
19243669-7	2009	Polyphenols cited in the present review seem to be able to modulate the expression of transcription factors such as runt-related transcription factor-2 (Runx2) and Osterix, NF-kappaB and activator protein-1 (AP-1).	Polyphenols	0-11	RUNX family transcription factor 2	Homo sapiens	153-158
19243669-7	2009	Polyphenols cited in the present review seem to be able to modulate the expression of transcription factors such as runt-related transcription factor-2 (Runx2) and Osterix, NF-kappaB and activator protein-1 (AP-1).	Polyphenols	0-11	Sp7 transcription factor	Homo sapiens	164-171
19243669-8	2009	It appears that polyphenols may act on cellular signalling such as mitogen-activated protein kinase (MAPK), bone morphogenetic protein (BMP), oestrogen receptor and osteoprotegerin/receptor activator of NF-kappaB ligand (OPG/RANKL) and thus may affect osteoblast functions.	Polyphenols	16-27	bone morphogenetic protein 1	Homo sapiens	108-134
19243669-8	2009	It appears that polyphenols may act on cellular signalling such as mitogen-activated protein kinase (MAPK), bone morphogenetic protein (BMP), oestrogen receptor and osteoprotegerin/receptor activator of NF-kappaB ligand (OPG/RANKL) and thus may affect osteoblast functions.	Polyphenols	16-27	bone morphogenetic protein 1	Homo sapiens	136-139
19243669-8	2009	It appears that polyphenols may act on cellular signalling such as mitogen-activated protein kinase (MAPK), bone morphogenetic protein (BMP), oestrogen receptor and osteoprotegerin/receptor activator of NF-kappaB ligand (OPG/RANKL) and thus may affect osteoblast functions.	Polyphenols	16-27	TNF receptor superfamily member 11b	Homo sapiens	221-224
19243669-8	2009	It appears that polyphenols may act on cellular signalling such as mitogen-activated protein kinase (MAPK), bone morphogenetic protein (BMP), oestrogen receptor and osteoprotegerin/receptor activator of NF-kappaB ligand (OPG/RANKL) and thus may affect osteoblast functions.	Polyphenols	16-27	TNF superfamily member 11	Homo sapiens	225-230
19014921-10	2009	In addition, treatment of CD-1 mice, another susceptible strain, with an anti-inflammatory polyphenol, resveratrol, protected mice against the acetaminophen-induced liver injury, and the mice with attenuated toxicity revealed lower expression of TNF-alpha and higher expression of IL-6.	Polyphenols	91-101	CD1 antigen complex	Mus musculus	26-30
19370779-0	2009	Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression.	Polyphenols	25-36	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	21-24
19322813-0	2009	Protection of dystrophic muscle cells with polyphenols from green tea correlates with improved glutathione balance and increased expression of 67LR, a receptor for (-)-epigallocatechin gallate.	Polyphenols	43-54	ribosomal protein SA	Mus musculus	143-147
19193929-0	2009	Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb.	Polyphenols	9-20	angiotensinogen	Rattus norvegicus	67-81
19426686-0	2009	A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis.	Polyphenols	12-22	TNF superfamily member 10	Homo sapiens	147-152
18656336-0	2009	Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
18656336-0	2009	Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.	Polyphenols	4-15	transformation related protein 53, pseudogene	Mus musculus	97-100
18656336-0	2009	Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.	Polyphenols	4-15	Harvey rat sarcoma virus oncogene	Mus musculus	122-127
18656336-0	2009	Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.	Polyphenols	4-15	cyclin D1	Mus musculus	139-148
18656336-2	2009	Progression of lung lesions was restricted at the hyperplastic stage by tea polyphenols.	Polyphenols	76-87	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	72-75
18656336-6	2009	The tea polyphenols inhibited inflammatory response in the lung lesions on the 9th week, when decreased expression of H-ras and c-myc and increased expression of bax were noted.	Polyphenols	8-19	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	4-7
18656336-6	2009	The tea polyphenols inhibited inflammatory response in the lung lesions on the 9th week, when decreased expression of H-ras and c-myc and increased expression of bax were noted.	Polyphenols	8-19	Harvey rat sarcoma virus oncogene	Mus musculus	118-123
18656336-6	2009	The tea polyphenols inhibited inflammatory response in the lung lesions on the 9th week, when decreased expression of H-ras and c-myc and increased expression of bax were noted.	Polyphenols	8-19	BCL2-associated X protein	Mus musculus	162-165
18656336-7	2009	Prolonged treatment (&gt;9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week).	Polyphenols	44-55	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	40-43
18656336-7	2009	Prolonged treatment (&gt;9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week).	Polyphenols	44-55	cyclin D1	Mus musculus	150-159
18656336-7	2009	Prolonged treatment (&gt;9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week).	Polyphenols	44-55	B cell leukemia/lymphoma 2	Mus musculus	182-187
18656336-7	2009	Prolonged treatment (&gt;9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week).	Polyphenols	44-55	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	229-232
18656336-7	2009	Prolonged treatment (&gt;9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week).	Polyphenols	44-55	transformation related protein 53, pseudogene	Mus musculus	276-279
18656336-7	2009	Prolonged treatment (&gt;9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week).	Polyphenols	44-55	cyclin-dependent kinase inhibitor 1B	Mus musculus	305-308
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	37-40
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	transformation related protein 53, pseudogene	Mus musculus	148-151
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	BCL2-associated X protein	Mus musculus	185-188
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	B cell leukemia/lymphoma 2	Mus musculus	190-195
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	transformed mouse 3T3 cell double minute 2	Mus musculus	197-201
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	203-206
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	cyclin-dependent kinase inhibitor 1B	Mus musculus	211-214
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	Harvey rat sarcoma virus oncogene	Mus musculus	227-232
18656336-8	2009	These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points.	Polyphenols	41-52	cyclin D1	Mus musculus	244-253
19370779-0	2009	Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression.	Polyphenols	25-36	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	121-136
19370779-1	2009	AIM: To investigate the hepatoprotective activity of tea polyphenols (TP) and its relation with cytochrome P450 (CYP450) expression in mice.	Polyphenols	57-68	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	53-56
19370779-1	2009	AIM: To investigate the hepatoprotective activity of tea polyphenols (TP) and its relation with cytochrome P450 (CYP450) expression in mice.	Polyphenols	57-68	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	96-111
19370779-1	2009	AIM: To investigate the hepatoprotective activity of tea polyphenols (TP) and its relation with cytochrome P450 (CYP450) expression in mice.	Polyphenols	57-68	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	113-119
19056430-0	2009	Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity.	Polyphenols	12-22	acetylcholinesterase	Mus musculus	115-135
19125328-7	2009	The author reviews the studies on the protecting effects of natural antioxidants on neurons in neurodegenerative diseases, especially summarized the results about protective effect of green tea polyphenols on neurons against apoptosis of cellular and animal PD models, and of genestine and nicotine on neurons against A beta-induced apoptosis of hippocampal neuronal and transgenic mouse AD models.	Polyphenols	194-205	amyloid beta (A4) precursor protein	Mus musculus	318-324
19403032-0	2009	[Effect of tea polyphenols on expression of nuclear factor kappa B].	Polyphenols	15-26	nuclear factor kappa B subunit 1	Rattus norvegicus	44-66
19056430-1	2009	The aim of this study was to examine the effect of a polyphenol-rich extract (PrB) of Vaccinium angustifolium (wild blueberries) introduced intraperitoneally (i.p.)	Polyphenols	53-63	RB transcriptional corepressor 1	Mus musculus	78-81
19056430-10	2009	supplementation with the blueberry extract concentrated in polyphenols, is closely related to higher brain antioxidant properties and inhibition of AChE activity.	Polyphenols	59-70	acetylcholinesterase	Mus musculus	148-152
19183551-5	2009	We show that the conformations of polyphenol-bound alpha-synuclein monomers and dimers differ from those of unbound monomers and resemble amyloid fibrils.	Polyphenols	34-44	synuclein alpha	Homo sapiens	51-66
19276266-0	2009	Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease.	Polyphenols	70-81	tumor necrosis factor receptor superfamily, member 25	Mus musculus	89-94
19053991-7	2009	The polyphenols were not cytotoxic and blocked N-formyl-methyl-leucyl-phenylalanine-induced myeloperoxidase release and activity in human neutrophils.	Polyphenols	4-15	myeloperoxidase	Homo sapiens	92-107
19455263-2	2009	Studies have reported the cyclooxygenase COX-2-inhibitory activity of this polyphenol; however, none of the studies have established its antiinflammatory activity in the rat cotton pellet granuloma pouch model, which mimics subchronic inflammation in humans.	Polyphenols	75-85	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	41-46
19403032-1	2009	OBJECTIVE: To investigate the effect of tea polyphenols (TP) on expression of nuclear factor kappa B (NF-kB) in rats with alcoholic liver diseases and in cells treated with alcohol.	Polyphenols	44-55	nuclear factor kappa B subunit 1	Rattus norvegicus	78-100
19403032-1	2009	OBJECTIVE: To investigate the effect of tea polyphenols (TP) on expression of nuclear factor kappa B (NF-kB) in rats with alcoholic liver diseases and in cells treated with alcohol.	Polyphenols	44-55	nuclear factor kappa B subunit 1	Rattus norvegicus	102-107
19059456-3	2009	In this study, we found that black tea extract (BTE) and theaflavins (TFs), the major black tea polyphenols, inhibited the purified TrxR1 with IC(50) 44 microg/ml and 21+/-1 microg/ml, respectively.	Polyphenols	96-107	thioredoxin reductase 1	Homo sapiens	132-137
19204829-5	2009	Simultaneous overexpression of phenylalanine ammonia lyase (PAL) and overexpression/silencing HQT could be used for the production of functional food with increased polyphenols.	Polyphenols	165-176	phenylalanine ammonia-lyase	Nicotiana tabacum	31-58
19027755-1	2009	The study set out to determine (a) whether DNA damage is elevated in mice that carry mutations in the amyloid precursor protein (APP695swe) and presenilin 1 (PSEN1-dE9) that predispose to Alzheimer"s disease (AD) relative to non-transgenic control mice, and (b) whether increasing the intake of dietary polyphenols from curcumin or grape seed extract could reduce genomic instability events in a transgenic mouse model for AD.	Polyphenols	303-314	presenilin 1	Mus musculus	158-163
19204829-5	2009	Simultaneous overexpression of phenylalanine ammonia lyase (PAL) and overexpression/silencing HQT could be used for the production of functional food with increased polyphenols.	Polyphenols	165-176	shikimate O-hydroxycinnamoyltransferase-like	Nicotiana tabacum	94-97
19434841-4	2009	We performed a flexible molecular docking analysis between a set of polyphenols previously demonstrated to have the highest binding affinity and both the constitutive (from deposited PDB structures) and homology modeled active subunits of the IFN-gamma inducible proteasome, to provide insight into the possible mechanism of interaction.	Polyphenols	68-79	interferon gamma	Homo sapiens	243-252
18752302-0	2009	Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia.	Polyphenols	10-20	matrix metallopeptidase 9	Mus musculus	100-105
19262011-7	2009	Therefore, we also investigated the effect of these polyphenols on phosphorylation of ERK in C2C12 myotubes.	Polyphenols	52-63	mitogen-activated protein kinase 1	Mus musculus	86-89
18752302-0	2009	Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia.	Polyphenols	10-20	carbonic anhydrase 1	Mus musculus	130-133
18752302-0	2009	Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia.	Polyphenols	10-20	carbonic anhydrase 2	Mus musculus	138-141
18752302-13	2009	These results demonstrate that the green tea polyphenol EGCG suppresses MMP-9 activation and reduces the development of delayed neuronal death after transient global cerebral ischemia in mouse brain.	Polyphenols	45-55	matrix metallopeptidase 9	Mus musculus	72-77
19074205-3	2009	Catechol-O-methyltransferase (COMT) catalyzes catechol estrogens and tea polyphenols.	Polyphenols	73-84	catechol-O-methyltransferase	Homo sapiens	0-28
19294520-3	2009	We recently reported that combined grape polyphenols at physiologically relevant concentrations are more effective than individual compounds at inhibition of ERalpha(-), ERbeta(+) MDA-MB-231 breast cancer cell proliferation, cell cycle progression, and primary mammary tumor growth (Schlachterman et al., Transl Oncol 1:19-27, 2008).	Polyphenols	41-52	estrogen receptor 1	Homo sapiens	158-165
19074205-3	2009	Catechol-O-methyltransferase (COMT) catalyzes catechol estrogens and tea polyphenols.	Polyphenols	73-84	catechol-O-methyltransferase	Homo sapiens	30-34
18844254-6	2009	Mangifera indica L. and Thalassia testudinum extracts, two natural polyphenol-rich extracts, diminished CYP1A1/2 and 3A4 activities, but not the CYP2D6 activity.	Polyphenols	67-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110
19183881-3	2009	leaves (ACK) that contained high amount of polyphenols showed significant antioxidant activity against diphenylpicrylhydrazyl (DPPH) radicals and TNF-alpha-generated reactive oxygen species.	Polyphenols	43-54	tyrosine kinase non receptor 2	Homo sapiens	8-11
19183881-3	2009	leaves (ACK) that contained high amount of polyphenols showed significant antioxidant activity against diphenylpicrylhydrazyl (DPPH) radicals and TNF-alpha-generated reactive oxygen species.	Polyphenols	43-54	tumor necrosis factor	Homo sapiens	146-155
18984652-9	2009	EDHF-mediated relaxation and hyperpolarization to acetylcholine and red wine polyphenols were significantly impaired in mesenteric arteries from angiotensin II-treated rats in comparison with control animals, whereas nitric oxide-mediated relaxation was unaltered.	Polyphenols	77-88	angiotensinogen	Rattus norvegicus	145-159
19294520-3	2009	We recently reported that combined grape polyphenols at physiologically relevant concentrations are more effective than individual compounds at inhibition of ERalpha(-), ERbeta(+) MDA-MB-231 breast cancer cell proliferation, cell cycle progression, and primary mammary tumor growth (Schlachterman et al., Transl Oncol 1:19-27, 2008).	Polyphenols	41-52	estrogen receptor 2	Homo sapiens	170-176
19082476-0	2009	Extra-virgin olive oil polyphenols inhibit HER2 (erbB-2)-induced malignant transformation in human breast epithelial cells: relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on the tyrosine kinase activity of HER2.	Polyphenols	23-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-47
19082476-0	2009	Extra-virgin olive oil polyphenols inhibit HER2 (erbB-2)-induced malignant transformation in human breast epithelial cells: relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on the tyrosine kinase activity of HER2.	Polyphenols	23-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	287-291
18637709-0	2009	Red wine polyphenols affect the collagen composition in the aorta after oxidative damage induced by chronic administration of CCl(4).	Polyphenols	9-20	C-C motif chemokine ligand 4	Homo sapiens	126-132
19155632-0	2009	eNOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries.	Polyphenols	29-39	nitric oxide synthase 3	Homo sapiens	0-4
19384583-1	2009	Polyphenols extracted from grape seeds are able to inhibit amyloid-beta (Abeta) aggregation, reduce Abeta production and protect against Abeta neurotoxicity in vitro.	Polyphenols	0-11	amyloid beta (A4) precursor protein	Mus musculus	73-78
19384583-1	2009	Polyphenols extracted from grape seeds are able to inhibit amyloid-beta (Abeta) aggregation, reduce Abeta production and protect against Abeta neurotoxicity in vitro.	Polyphenols	0-11	amyloid beta (A4) precursor protein	Mus musculus	100-105
19384583-9	2009	Conclusively, polyphenol-rich GSE prevents the Abeta deposition and attenuates the inflammation in the brain of a transgenic mouse model, and this thus is promising in delaying development of AD.	Polyphenols	14-24	amyloid beta (A4) precursor protein	Mus musculus	47-52
18637709-10	2009	This effect of polyphenols is most likely the result of their influence on MMP-1 and TIMP activities through which they positively influence the collagen types I and III content ratio in the vascular wall in favor of the type III collagen.	Polyphenols	15-26	matrix metallopeptidase 1	Homo sapiens	75-80
19440378-9	2009	Provinols enhanced NO bioavailability resulting from increased nitric oxide (NO) production through enhanced endothelial NO-synthase (eNOS) activity and reduced superoxide anion release via decreased expression of NADPH oxidase membrane sub-unit, Nox-1.	Polyphenols	0-9	NADPH oxidase 1	Rattus norvegicus	247-252
18637709-10	2009	This effect of polyphenols is most likely the result of their influence on MMP-1 and TIMP activities through which they positively influence the collagen types I and III content ratio in the vascular wall in favor of the type III collagen.	Polyphenols	15-26	TIMP metallopeptidase inhibitor 1	Homo sapiens	85-89
19035656-6	2008	Liver GST activity, however, was approximately 25% higher than controls for the freeze-dried whole blueberry, blueberry polyphenol, and 1% flavonoid groups.	Polyphenols	120-130	hematopoietic prostaglandin D synthase	Rattus norvegicus	6-9
18992738-8	2008	Other tea polyphenols, including theaflavin-3,3"-digallate (TF-3) and (-) epigallocatechin-3-gallate (EGCG), also induced the expression of RGS10 and RGS14, but not RGS4.	Polyphenols	10-21	regulator of G protein signaling 10	Homo sapiens	140-145
18992738-8	2008	Other tea polyphenols, including theaflavin-3,3"-digallate (TF-3) and (-) epigallocatechin-3-gallate (EGCG), also induced the expression of RGS10 and RGS14, but not RGS4.	Polyphenols	10-21	regulator of G protein signaling 14	Homo sapiens	150-155
18992738-8	2008	Other tea polyphenols, including theaflavin-3,3"-digallate (TF-3) and (-) epigallocatechin-3-gallate (EGCG), also induced the expression of RGS10 and RGS14, but not RGS4.	Polyphenols	10-21	regulator of G protein signaling 4	Homo sapiens	165-169
18992738-10	2008	These results showed for the first time that tea polyphenols can induce the expression of selective RGS genes and that the gallate moiety may be important in this induction.	Polyphenols	49-60	paired like homeodomain 2	Homo sapiens	100-103
19242551-0	2009	Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.	Polyphenols	10-21	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	75-81
19242551-7	2009	Epigallocatechin gallate (EGCG) - a member of a natural polyphenols family, found in great amount in green tea leaves - is a specific and safe DYRK1A inhibitor.	Polyphenols	56-67	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	143-149
17869316-0	2008	Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay.	Polyphenols	18-29	aryl hydrocarbon receptor	Homo sapiens	33-58
19094209-8	2008	Small interfering RNA-induced depletion of HER2 protein and lapatinib-induced blockade of HER2 tyrosine kinase activity both significantly prevented EVOO polyphenols-induced cytotoxicity.	Polyphenols	154-165	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-94
18490157-3	2008	Monitoring the levels of lipid and total polyphenols showed a reduction of 81% and 72% for lipids and of 75% and 76% for polyphenols in M1 and M2, respectively.	Polyphenols	41-52	myoregulin	Homo sapiens	136-145
18490157-3	2008	Monitoring the levels of lipid and total polyphenols showed a reduction of 81% and 72% for lipids and of 75% and 76% for polyphenols in M1 and M2, respectively.	Polyphenols	121-132	myoregulin	Homo sapiens	136-145
18479901-0	2008	Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor.	Polyphenols	12-23	androgen receptor	Homo sapiens	130-147
19083497-0	2008	Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity.	Polyphenols	24-34	arachidonate 5-lipoxygenase	Homo sapiens	105-119
17869316-2	2008	We investigated AhR activation by some vegetable constituents, including flavonoids, tannins, and related polyphenols, using an AhR-based in vitro bioassay for dioxins.	Polyphenols	106-117	aryl hydrocarbon receptor	Homo sapiens	16-19
17869316-7	2008	On the basis of these finding, we discuss the implications of polyphenols on the AhR-signaling pathway.	Polyphenols	62-73	aryl hydrocarbon receptor	Homo sapiens	81-84
18164321-10	2008	Again, non-infected and infected cells differed significantly in the NO response, while inhibition of IFN-gamma and/or LPS-induced NO production by the tested polyphenols strongly depended on the given time of exposure and the sequence of immunological stimuli.	Polyphenols	159-170	interferon gamma	Mus musculus	102-111
18958624-3	2008	Methanolic extract of E. stolonifera (MEE), which contains a high content of polyphenols, showed strong inhibition of alpha-glucosidase in vitro.	Polyphenols	77-88	sucrase-isomaltase	Homo sapiens	118-135
18164321-10	2008	Again, non-infected and infected cells differed significantly in the NO response, while inhibition of IFN-gamma and/or LPS-induced NO production by the tested polyphenols strongly depended on the given time of exposure and the sequence of immunological stimuli.	Polyphenols	159-170	toll-like receptor 4	Mus musculus	119-122
18930055-1	2008	We have examined polyphenols as potential inhibitors of UDP-glucose dehydrogenase (UGDH) activity.	Polyphenols	17-28	UDP-glucose 6-dehydrogenase	Homo sapiens	56-81
19063841-1	2008	OBJECTIVE: To study the anticancer effects of tea polyphenols on colorectal cancer with microsatellite instability (MSI) in nude mice and to explore its mechanism.	Polyphenols	50-61	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	46-49
19063841-4	2008	Then, the nude mice were divided into untreated group and 50, 75 and 100 mg/kg tea polyphenols groups.	Polyphenols	83-94	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	79-82
19063841-5	2008	The mice in tea polyphenols-treated groups were given intra-abdominal injection of 50, 75 and 100 mg/kg tea polyphenols respectively.	Polyphenols	16-27	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	12-15
19063841-5	2008	The mice in tea polyphenols-treated groups were given intra-abdominal injection of 50, 75 and 100 mg/kg tea polyphenols respectively.	Polyphenols	16-27	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	104-107
19063841-5	2008	The mice in tea polyphenols-treated groups were given intra-abdominal injection of 50, 75 and 100 mg/kg tea polyphenols respectively.	Polyphenols	108-119	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	12-15
19063841-8	2008	The study found that tea polyphenols could inhibit the tumor growth.	Polyphenols	25-36	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	21-24
19063841-11	2008	After using the tea polyphenols, the microsatellite tended to become stable.	Polyphenols	20-31	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	16-19
19063841-12	2008	CONCLUSION: Tea polyphenols can inhibit the mismatch-repair-gene deficient colorectal cancer in nude mice by down-regulating the microsatellite instability.	Polyphenols	16-27	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	12-15
18928297-3	2008	This paper investigates the suppression by a cacao polyphenol extract (CPE) of AhR transformation in vivo.	Polyphenols	51-61	aryl-hydrocarbon receptor	Mus musculus	79-82
18930055-1	2008	We have examined polyphenols as potential inhibitors of UDP-glucose dehydrogenase (UGDH) activity.	Polyphenols	17-28	UDP-glucose 6-dehydrogenase	Homo sapiens	83-87
18930055-3	2008	Western blot analysis showed that gallic acid and quercetin did not affect UGDH protein expression, suggesting that UGDH activity is inhibited by polyphenols at the post-translational level.	Polyphenols	146-157	UDP-glucose 6-dehydrogenase	Homo sapiens	116-120
19008647-2	2008	Recently, resveratrol and its analogues, which are polyphenols, have been reported to activate the deacetylase activity of SIRT1 in an in vitro assay and to expand the life-span of several species through Sir2 and the orthologs.	Polyphenols	51-62	sirtuin 1	Homo sapiens	123-128
19000313-3	2008	Numerous plant polyphenols have been shown to inhibit the activation of AP-1, which often is ascribed to the anti-oxidant properties of these natural products.	Polyphenols	15-26	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-76
19000313-4	2008	METHODS: In the present study, a library of substituted trans-stilbenes, including polyphenols, was screened for activity against the TPA-induced activation of AP-1 using the Panomics AP-1 Reporter 293 Stable Cell Line, which is designed for screening potential inhibitors or activators.	Polyphenols	83-94	plasminogen activator, tissue type	Homo sapiens	134-137
19000313-4	2008	METHODS: In the present study, a library of substituted trans-stilbenes, including polyphenols, was screened for activity against the TPA-induced activation of AP-1 using the Panomics AP-1 Reporter 293 Stable Cell Line, which is designed for screening potential inhibitors or activators.	Polyphenols	83-94	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-164
19008647-2	2008	Recently, resveratrol and its analogues, which are polyphenols, have been reported to activate the deacetylase activity of SIRT1 in an in vitro assay and to expand the life-span of several species through Sir2 and the orthologs.	Polyphenols	51-62	sirtuin 1	Homo sapiens	205-209
18840529-2	2008	In this study, we investigated whether the cottonseed polyphenol, -(-)gossypol, a BH3 mimetic, can reduce the expression of pro-survival, or increase the expression of pro-apoptotic, Bcl2 family proteins and thereby effectively sensitize otherwise resistant bladder cancer cells to the standard chemotherapeutic drugs gemcitabine, paclitaxel and carboplatin.	Polyphenols	54-64	BCL2 apoptosis regulator	Homo sapiens	183-187
18755807-2	2008	Resveratrol, a dietary polyphenol, has been identified as a potent activator for both SIRT1 and AMPK.	Polyphenols	23-33	sirtuin 1	Mus musculus	86-91
18808139-5	2008	Electrophoresis of proteins in combination with thiolysis analysis of tannins indicated proline-rich protein (PRP)-polyphenol complexes in precipitated fractions and also in the soluble ones with individual differences.	Polyphenols	115-125	complement component 4 binding protein alpha	Homo sapiens	88-108
18808139-5	2008	Electrophoresis of proteins in combination with thiolysis analysis of tannins indicated proline-rich protein (PRP)-polyphenol complexes in precipitated fractions and also in the soluble ones with individual differences.	Polyphenols	115-125	complement component 4 binding protein alpha	Homo sapiens	110-113
18672067-1	2008	Recent reports of the slow-tight binding inhibition of bovine liver dihydrofolate reductase (bDHFR) in the presence of polyphenols isolated from green tea leaves has spurred renewed interest in the biochemical properties of bDHFR.	Polyphenols	119-130	dihydrofolate reductase	Bos taurus	68-91
18722507-3	2008	Protective effects of green tea polyphenols on UV-C light irradiation-induced apoptosis in cortical neurons were demonstrated by testing the content of Bax, which is involved in cell death.	Polyphenols	32-43	BCL2 associated X, apoptosis regulator	Rattus norvegicus	152-155
18722507-4	2008	The expression of active Bax in cultured rat cortical neurons was inhibited significantly by green tea polyphenols compared to UV irradiation group tested by the immunoprecipitation assay and Western blot assay.	Polyphenols	103-114	BCL2 associated X, apoptosis regulator	Rattus norvegicus	25-28
18722507-6	2008	Our results demonstrated that the green tea polyphenols inhibited the active Bax expression, suggesting a neuroprotective effect of green tea polyphenols against the UV-C light irradiation-induced injury on cortical neurons.	Polyphenols	44-55	BCL2 associated X, apoptosis regulator	Rattus norvegicus	77-80
18722507-6	2008	Our results demonstrated that the green tea polyphenols inhibited the active Bax expression, suggesting a neuroprotective effect of green tea polyphenols against the UV-C light irradiation-induced injury on cortical neurons.	Polyphenols	142-153	BCL2 associated X, apoptosis regulator	Rattus norvegicus	77-80
18985801-6	2008	However, in recent years a possible novel aspect in the mode of action of these compounds has been suggested; that is, the ultimate stimulation of the heme oxygenase-1 (HO-1) pathway is likely to account for the established and powerful antioxidant/anti-inflammatory properties of these polyphenols.	Polyphenols	287-298	heme oxygenase 1	Homo sapiens	151-167
18985801-6	2008	However, in recent years a possible novel aspect in the mode of action of these compounds has been suggested; that is, the ultimate stimulation of the heme oxygenase-1 (HO-1) pathway is likely to account for the established and powerful antioxidant/anti-inflammatory properties of these polyphenols.	Polyphenols	287-298	heme oxygenase 1	Homo sapiens	169-173
18622895-2	2008	Some polyphenols have been shown to downregulate resistin expression in adipocytes.	Polyphenols	5-16	resistin	Homo sapiens	49-57
18852136-0	2008	Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism.	Polyphenols	8-19	BCL2 apoptosis regulator	Homo sapiens	105-110
18813848-0	2008	Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays.	Polyphenols	44-55	fatty acid synthase	Homo sapiens	84-103
18646006-3	2008	We sought to determine whether supplementation with polyphenol-rich Cynara cardunculus (wild artichoke, traditional component of the Mediterranean diet) modulates MMP-9 expression and activity in cell cultures.	Polyphenols	52-62	matrix metallopeptidase 9	Homo sapiens	163-168
18852136-9	2008	Antisense oligodeoxynucleotides to human superoxide dismutase 2 and/or ectopic bcl-2 overexpression avoided polyphenols and chemoradiotherapy-induced colorectal cancer elimination and showed that the mangano-type superoxide dismutase and Bcl-2 are key targets in the molecular mechanism activated by the combined application of t-PTER and QUER.	Polyphenols	108-119	BCL2 apoptosis regulator	Homo sapiens	79-84
18852136-9	2008	Antisense oligodeoxynucleotides to human superoxide dismutase 2 and/or ectopic bcl-2 overexpression avoided polyphenols and chemoradiotherapy-induced colorectal cancer elimination and showed that the mangano-type superoxide dismutase and Bcl-2 are key targets in the molecular mechanism activated by the combined application of t-PTER and QUER.	Polyphenols	108-119	BCL2 apoptosis regulator	Homo sapiens	238-243
18852136-9	2008	Antisense oligodeoxynucleotides to human superoxide dismutase 2 and/or ectopic bcl-2 overexpression avoided polyphenols and chemoradiotherapy-induced colorectal cancer elimination and showed that the mangano-type superoxide dismutase and Bcl-2 are key targets in the molecular mechanism activated by the combined application of t-PTER and QUER.	Polyphenols	108-119	phosphotriesterase related	Homo sapiens	330-334
18643978-0	2008	AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato: expression in fruit results in very high levels of both types of polyphenol.	Polyphenols	138-148	myb domain protein 12	Arabidopsis thaliana	0-7
19083478-7	2008	Analysis of gene expression showed that genes such as CDK2, FAS, LEF1, PRKCE, and PTGS2, belonging to the NFkappaB, phospholipase C, and calcium signaling pathways, were down-regulated in tumors that developed in grape polyphenol-treated mice.	Polyphenols	219-229	cyclin-dependent kinase 2	Mus musculus	54-58
19083478-7	2008	Analysis of gene expression showed that genes such as CDK2, FAS, LEF1, PRKCE, and PTGS2, belonging to the NFkappaB, phospholipase C, and calcium signaling pathways, were down-regulated in tumors that developed in grape polyphenol-treated mice.	Polyphenols	219-229	lymphoid enhancer binding factor 1	Mus musculus	65-69
19083478-7	2008	Analysis of gene expression showed that genes such as CDK2, FAS, LEF1, PRKCE, and PTGS2, belonging to the NFkappaB, phospholipase C, and calcium signaling pathways, were down-regulated in tumors that developed in grape polyphenol-treated mice.	Polyphenols	219-229	protein kinase C, epsilon	Mus musculus	71-76
19083478-7	2008	Analysis of gene expression showed that genes such as CDK2, FAS, LEF1, PRKCE, and PTGS2, belonging to the NFkappaB, phospholipase C, and calcium signaling pathways, were down-regulated in tumors that developed in grape polyphenol-treated mice.	Polyphenols	219-229	prostaglandin-endoperoxide synthase 2	Mus musculus	82-87
19083478-7	2008	Analysis of gene expression showed that genes such as CDK2, FAS, LEF1, PRKCE, and PTGS2, belonging to the NFkappaB, phospholipase C, and calcium signaling pathways, were down-regulated in tumors that developed in grape polyphenol-treated mice.	Polyphenols	219-229	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-114
18759451-3	2008	Our aim was to investigate the effects of Wonderful variety pomegranate juice (WPJ) and pomegranate polyphenol extract (WPOMxl) consumption on PON1 association with HDL in diabetic patients.	Polyphenols	100-110	paraoxonase 1	Homo sapiens	143-147
18694800-9	2008	This polyphenol, however, decreased the protein level of CYP1A1/1A2 and CYP1B1 isozymes enhanced by B[a]P. All phenolics, particularly resveratrol, significantly (by 129-174%) increased the activity of NQO1 in comparison with B[a]P-treated animals.	Polyphenols	5-15	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	57-63
18694800-9	2008	This polyphenol, however, decreased the protein level of CYP1A1/1A2 and CYP1B1 isozymes enhanced by B[a]P. All phenolics, particularly resveratrol, significantly (by 129-174%) increased the activity of NQO1 in comparison with B[a]P-treated animals.	Polyphenols	5-15	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	72-78
18694800-9	2008	This polyphenol, however, decreased the protein level of CYP1A1/1A2 and CYP1B1 isozymes enhanced by B[a]P. All phenolics, particularly resveratrol, significantly (by 129-174%) increased the activity of NQO1 in comparison with B[a]P-treated animals.	Polyphenols	5-15	NAD(P)H dehydrogenase, quinone 1	Mus musculus	202-206
18327875-6	2008	Curcumin is a polyphenol present in the spice turmeric, which can directly scavenge free radicals such as superoxide anion and nitric oxide and modulate important signaling pathways mediated via NF-kappaB and mitogen-activated protein kinase pathways.	Polyphenols	14-24	nuclear factor kappa B subunit 1	Homo sapiens	195-204
18611398-6	2008	The results showed that grape seed polyphenols catechin and Pc B(4) pretreatment would protect cardiomyocytes against doxorubicin-induced toxicity by decreasing reactive oxygen species generation as well as the number of apoptotic cells, preventing DNA fragmentation, regulating the expression levels of the pro-apoptotic protein Bax-alpha and the anti-apoptotic protein Bcl-2, and inhibiting apoptotic signaling pathways.	Polyphenols	35-46	BCL2 apoptosis regulator	Homo sapiens	371-376
18806962-3	2008	In this study, we investigated natural compounds that can overcome resistance to TRAIL, and found that butein, a polyphenol, exhibits significant synergism with TRAIL.	Polyphenols	113-123	TNF superfamily member 10	Homo sapiens	81-86
18806962-3	2008	In this study, we investigated natural compounds that can overcome resistance to TRAIL, and found that butein, a polyphenol, exhibits significant synergism with TRAIL.	Polyphenols	113-123	TNF superfamily member 10	Homo sapiens	161-166
18421014-3	2008	We demonstrate here that curcumin (diferuloylmethane), a dietary polyphenol, at nanomolar concentrations specifically restores cigarette smoke extract (CSE)- or oxidative stress-impaired HDAC2 activity and corticosteroid efficacy in vitro with an EC(50) of approximately 30 nM and 200 nM, respectively.	Polyphenols	65-75	histone deacetylase 2	Homo sapiens	187-192
18837911-7	2008	Induction of apoptosis was observed, after the treatment with tea polyphenols, as shown by increased DNA breakdown and activation of the apoptotic markers, cytochrome c, caspase 3, and poly-(ADP-ribose) polymerase.	Polyphenols	66-77	caspase 3	Rattus norvegicus	170-179
18837911-7	2008	Induction of apoptosis was observed, after the treatment with tea polyphenols, as shown by increased DNA breakdown and activation of the apoptotic markers, cytochrome c, caspase 3, and poly-(ADP-ribose) polymerase.	Polyphenols	66-77	poly (ADP-ribose) polymerase 1	Rattus norvegicus	185-213
18716168-0	2008	Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.	Polyphenols	137-147	insulin	Homo sapiens	30-37
18327875-7	2008	Polyphenols also down-regulate expression of pro-inflammatory mediators, matrix metalloproteinases, adhesion molecules, and growth factor receptor genes and they up-regulate HDAC2 in the lung.	Polyphenols	0-11	histone deacetylase 2	Homo sapiens	174-179
18787295-0	2008	Green tea polyphenol EGCG signaling pathway through the 67-kDa laminin receptor.	Polyphenols	10-20	ribosomal protein SA	Homo sapiens	56-79
18317887-0	2008	Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model.	Polyphenols	92-103	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	15-23
18665171-0	2008	Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells.	Polyphenols	21-31	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	57-61
18155512-3	2008	In this study, we examined the effect of (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced MUC5AC gene expression and secretion in NHNE cells.	Polyphenols	92-102	interleukin 1 beta	Homo sapiens	107-115
18624451-5	2008	In addition, tea polyphenols and diallyl trisulfide could increase glutathione S-transferase activity remarkably.	Polyphenols	17-28	glutathione S-transferase kappa 1	Homo sapiens	67-92
18636219-8	2008	CONCLUSIONS: The intervention with apple juice results in bioavailable concentrations of related polyphenols in the gut lumen, which could contribute to reduced genotoxicity, enhanced antigenotoxicity and favorable modulation of GSTT2 gene expression in some individuals.	Polyphenols	97-108	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	229-234
18511942-4	2008	The polyphenol (-)-epigallocatechin gallate efficiently inhibits the fibrillogenesis of both alpha-synuclein and amyloid-beta by directly binding to the natively unfolded polypeptides and preventing their conversion into toxic, on-pathway aggregation intermediates.	Polyphenols	4-14	synuclein alpha	Homo sapiens	93-108
18420994-1	2008	OBJECTIVE: Resveratrol (3,5,4"-trihydroxystilbene), a polyphenol found in red wine, is known to activate sirtuin1 (SIRT1), a longevity gene.	Polyphenols	54-64	sirtuin 1	Rattus norvegicus	105-113
18420994-1	2008	OBJECTIVE: Resveratrol (3,5,4"-trihydroxystilbene), a polyphenol found in red wine, is known to activate sirtuin1 (SIRT1), a longevity gene.	Polyphenols	54-64	sirtuin 1	Rattus norvegicus	115-120
18512968-2	2008	Because little is known about the protective role of natural antioxidants, such as polyphenols, for the myeloperoxidase-derived DNA damage, we screened the inhibitory effects of various phenolic antioxidants on the chlorination of the 2"-deoxycytidine residue by HOCl in vitro and found that green tea catechins, especially (-)-epicatechin gallate (ECg) and (-)-epigallocatechin gallate (EGCg), significantly inhibited the chlorination.	Polyphenols	83-94	myeloperoxidase	Homo sapiens	104-119
18496818-2	2008	It has been suggested that the tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) displays some antidiabetic effects, but the mechanism for EGCG insulin-enhancing effects is incompletely understood.	Polyphenols	35-45	insulin	Homo sapiens	147-154
18482975-2	2008	Because we have recently defined AMPK activation as a key mechanism for the beneficial effects of polyphenols on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in type 1 diabetic mice, we hypothesize that polyphenol-activated SIRT1 acts upstream of AMPK signaling and hepatocellular lipid metabolism.	Polyphenols	98-109	sirtuin 1	Mus musculus	243-248
18482975-2	2008	Because we have recently defined AMPK activation as a key mechanism for the beneficial effects of polyphenols on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in type 1 diabetic mice, we hypothesize that polyphenol-activated SIRT1 acts upstream of AMPK signaling and hepatocellular lipid metabolism.	Polyphenols	98-108	sirtuin 1	Mus musculus	243-248
18482975-3	2008	Here we show that polyphenols, including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser(428), and AMPK activity.	Polyphenols	18-29	sirtuin 1	Homo sapiens	99-104
18482975-3	2008	Here we show that polyphenols, including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser(428), and AMPK activity.	Polyphenols	18-29	serine/threonine kinase 11	Homo sapiens	127-131
18482975-3	2008	Here we show that polyphenols, including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser(428), and AMPK activity.	Polyphenols	18-28	sirtuin 1	Homo sapiens	99-104
18482975-3	2008	Here we show that polyphenols, including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser(428), and AMPK activity.	Polyphenols	18-28	serine/threonine kinase 11	Homo sapiens	127-131
18482975-4	2008	Polyphenols substantially prevent the impairment in phosphorylation of AMPK and its downstream target, ACC (acetyl-CoA carboxylase), elevation in expression of FAS (fatty acid synthase), and lipid accumulation in human HepG2 hepatocytes exposed to high glucose.	Polyphenols	0-11	fatty acid synthase	Homo sapiens	160-163
18482975-4	2008	Polyphenols substantially prevent the impairment in phosphorylation of AMPK and its downstream target, ACC (acetyl-CoA carboxylase), elevation in expression of FAS (fatty acid synthase), and lipid accumulation in human HepG2 hepatocytes exposed to high glucose.	Polyphenols	0-11	fatty acid synthase	Homo sapiens	165-184
18482975-5	2008	These effects of polyphenols are largely abolished by pharmacological and genetic inhibition of SIRT1, suggesting that the stimulation of AMPK and lipid-lowering effect of polyphenols depend on SIRT1 activity.	Polyphenols	17-28	sirtuin 1	Homo sapiens	96-101
18482975-5	2008	These effects of polyphenols are largely abolished by pharmacological and genetic inhibition of SIRT1, suggesting that the stimulation of AMPK and lipid-lowering effect of polyphenols depend on SIRT1 activity.	Polyphenols	17-28	sirtuin 1	Homo sapiens	194-199
18482975-5	2008	These effects of polyphenols are largely abolished by pharmacological and genetic inhibition of SIRT1, suggesting that the stimulation of AMPK and lipid-lowering effect of polyphenols depend on SIRT1 activity.	Polyphenols	172-183	sirtuin 1	Homo sapiens	96-101
18482975-5	2008	These effects of polyphenols are largely abolished by pharmacological and genetic inhibition of SIRT1, suggesting that the stimulation of AMPK and lipid-lowering effect of polyphenols depend on SIRT1 activity.	Polyphenols	172-183	sirtuin 1	Homo sapiens	194-199
18482975-8	2008	Moreover, LKB1, but not CaMKKbeta, is required for activation of AMPK by polyphenols and SIRT1.	Polyphenols	73-84	serine/threonine kinase 11	Homo sapiens	10-14
18482975-10	2008	Targeting SIRT1/LKB1/AMPK signaling by polyphenols may have potential therapeutic implications for dyslipidemia and accelerated atherosclerosis in diabetes and age-related diseases.	Polyphenols	39-50	sirtuin 1	Homo sapiens	10-15
18482975-10	2008	Targeting SIRT1/LKB1/AMPK signaling by polyphenols may have potential therapeutic implications for dyslipidemia and accelerated atherosclerosis in diabetes and age-related diseases.	Polyphenols	39-50	serine/threonine kinase 11	Homo sapiens	16-20
18400024-9	2008	CONCLUSIONS: PBP-2 was observed to be the most potent polymeric polyphenol fraction and PBP-4 and PBP-5 showed only marginal activity, whereas PBP-1 and PBP-3 displayed intermediate efficacies.	Polyphenols	64-74	phosphatidylethanolamine binding protein 2	Mus musculus	13-18
18400024-9	2008	CONCLUSIONS: PBP-2 was observed to be the most potent polymeric polyphenol fraction and PBP-4 and PBP-5 showed only marginal activity, whereas PBP-1 and PBP-3 displayed intermediate efficacies.	Polyphenols	64-74	phosphatidylethanolamine binding protein 1	Mus musculus	13-16
18419748-1	2008	BACKGROUND: Wine polyphenol quercetin upregulates tissue-type plasminogen activator (t-PA) transcription in cultured human umbilical cord vein endothelial cells (HUVECs).	Polyphenols	17-27	plasminogen activator, tissue type	Homo sapiens	50-83
18419748-1	2008	BACKGROUND: Wine polyphenol quercetin upregulates tissue-type plasminogen activator (t-PA) transcription in cultured human umbilical cord vein endothelial cells (HUVECs).	Polyphenols	17-27	plasminogen activator, tissue type	Homo sapiens	85-89
18457947-0	2008	Enterodiol and enterolactone, two major diet-derived polyphenol metabolites have different impact on ERalpha transcriptional activation in human breast cancer cells.	Polyphenols	53-63	estrogen receptor 1	Homo sapiens	101-108
18522021-5	2008	The extent of MS2 reduction was significantly (P &lt; 0.05) decreased when the H2O2 spray was delivered at 10 or 25 degrees C compared with 50 degrees C. In the course of aerobic storage at 4 degrees C, lettuce treated with UV light and H2O2 (10 or 25 degrees C) developed discoloration (polyphenol accumulation) within 6 days.	Polyphenols	288-298	MS2	Homo sapiens	14-17
18424588-0	2008	Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages.	Polyphenols	9-19	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	97-116
18082923-0	2008	Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG.	Polyphenols	90-100	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
18646540-0	2008	[Inhibitory effect of tea polyphenols and EGCG on cultured hypertrophic myocyte induced by Ang II].	Polyphenols	26-37	angiogenin	Rattus norvegicus	91-94
18646540-1	2008	OBJECTIVE: To observe the potential effect of tea polyphenols and EGCG on cultured hypertrophic myocyte induced by Ang II.	Polyphenols	50-61	angiotensinogen	Rattus norvegicus	115-121
18646540-5	2008	But all those in tea polyphenols and EGCG group decreased in a dose-dependent manner, when compared to Ang II group.	Polyphenols	21-32	angiotensinogen	Rattus norvegicus	103-109
18646540-7	2008	CONCLUSIONS: Tea polyphenols and EGCG can effectively inhibit hypertrophy of cultured neonatal rat heart myocytes induced by Ang II.	Polyphenols	17-28	angiotensinogen	Rattus norvegicus	125-131
18467956-4	2008	The objective of this study was to examine whether the polyphenol compound curcumin has the capacity to block progestin-induced secretion of VEGF from T47-D human breast cancer cells.	Polyphenols	55-65	vascular endothelial growth factor A	Homo sapiens	141-145
18433082-5	2008	With data-dependent MS/MS analysis by collecting the MS2 and MS3 spectra of the most intense ions in the sample, we identified more than twenty metabolites of tea polyphenols from human urine samples.	Polyphenols	163-174	MS2	Homo sapiens	53-56
18433082-5	2008	With data-dependent MS/MS analysis by collecting the MS2 and MS3 spectra of the most intense ions in the sample, we identified more than twenty metabolites of tea polyphenols from human urine samples.	Polyphenols	163-174	MS3	Homo sapiens	61-64
18361748-7	2008	In plasma, we observed a positive correlation among SOD and CAT activities, resveratrol, and all anthocyanin contents, suggesting that these polyphenols may be, at least in part, responsible for this increased antioxidant defense.	Polyphenols	141-152	catalase	Rattus norvegicus	60-63
17498718-4	2008	Dealcoholized red wine and polyphenols-stripped red wine induced similar increase in FRAP values which represented nearly half the effect of the original red wine.	Polyphenols	27-38	mechanistic target of rapamycin kinase	Homo sapiens	85-89
17998943-0	2008	Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis.	Polyphenols	10-20	TNF superfamily member 10	Homo sapiens	77-82
18157146-1	2008	We report the anticarcinogenic, anti-aging polyphenol resveratrol activates the radio- and chemo-inducible cancer gene therapy vector Ad.Egr.TNF, a replication-deficient adenovirus that expresses human tumor necrosis factor alpha (TNF-alpha) under control of the Egr-1 promoter.	Polyphenols	43-53	tumor necrosis factor	Homo sapiens	141-144
18063583-1	2008	The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases.	Polyphenols	113-123	ribosomal protein SA pseudogene 11	Homo sapiens	10-26
18607509-1	2008	Grape polyphenols can act as antioxidants, antiangiogenics, and selective estrogen receptor (ER) modifiers and are therefore especially relevant for gynecological cancers such as breast cancer.	Polyphenols	6-17	estrogen receptor 1 (alpha)	Mus musculus	74-91
18607509-1	2008	Grape polyphenols can act as antioxidants, antiangiogenics, and selective estrogen receptor (ER) modifiers and are therefore especially relevant for gynecological cancers such as breast cancer.	Polyphenols	6-17	estrogen receptor 1 (alpha)	Mus musculus	93-95
18063583-1	2008	The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases.	Polyphenols	113-123	ribosomal protein SA pseudogene 11	Homo sapiens	28-32
18234131-0	2008	Chromium and polyphenols from cinnamon improve insulin sensitivity.	Polyphenols	13-24	insulin	Homo sapiens	47-54
18234131-1	2008	Naturally-occurring compounds that have been shown to improve insulin sensitivity include Cr and polyphenols found in cinnamon (Cinnamomon cassia).	Polyphenols	97-108	insulin	Homo sapiens	62-69
18234131-5	2008	It has also been shown that cinnamon polyphenols improve insulin sensitivity in in vitro, animal and human studies.	Polyphenols	37-48	insulin	Homo sapiens	57-64
18991694-5	2008	Results will demonstrate that in cells both the expression of p38 and ERK1/2 augments in the presence of red wine polyphenols, but their expression drops in the presence of polyphenols plus lipopolysaccharides (LPS).	Polyphenols	114-125	mitogen-activated protein kinase 1	Homo sapiens	62-65
17997062-4	2008	AIM OF THE STUDY: To determine whether a methanol extract of Theobroma cacao L. (Sterculiaceae) beans enriched for polyphenols could inhibit CGRP expression, both an in vitro and an in vivo approach was taken.	Polyphenols	115-126	calcitonin-related polypeptide alpha	Rattus norvegicus	141-145
17984116-0	2008	Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade.	Polyphenols	33-44	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
18005251-0	2008	Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1a.	Polyphenols	10-21	forkhead box O1	Homo sapiens	100-106
18537614-2	2008	Diverse classes of chemical compounds including nucleotide analogues, adenosine analogues, aminobenzoic derivatives, polyphenols, hydrazines, phthalides, disulfides and antisenses are being discovered and evaluated as DNMT inhibitors targeting DNA hypermethylation.	Polyphenols	117-128	DNA methyltransferase 1	Homo sapiens	218-222
18991694-4	2008	In particular, we have investigated the involvement of polyphenols in the activation of p38 and ERK1/2 molecules belonging to the MAPK kinase family and on the expression of I kappaB alpha and p65/NF kappaB.	Polyphenols	55-66	mitogen-activated protein kinase 1	Homo sapiens	88-91
18991694-4	2008	In particular, we have investigated the involvement of polyphenols in the activation of p38 and ERK1/2 molecules belonging to the MAPK kinase family and on the expression of I kappaB alpha and p65/NF kappaB.	Polyphenols	55-66	mitogen-activated protein kinase 3	Homo sapiens	96-102
18991694-5	2008	Results will demonstrate that in cells both the expression of p38 and ERK1/2 augments in the presence of red wine polyphenols, but their expression drops in the presence of polyphenols plus lipopolysaccharides (LPS).	Polyphenols	114-125	mitogen-activated protein kinase 3	Homo sapiens	70-76
18991694-5	2008	Results will demonstrate that in cells both the expression of p38 and ERK1/2 augments in the presence of red wine polyphenols, but their expression drops in the presence of polyphenols plus lipopolysaccharides (LPS).	Polyphenols	173-184	mitogen-activated protein kinase 1	Homo sapiens	62-65
17962980-8	2008	A series of polyphenols were screened and a subset was shown to increase full-length SMN expression from SMN2.	Polyphenols	12-23	survival of motor neuron 1, telomeric	Homo sapiens	85-88
17962980-8	2008	A series of polyphenols were screened and a subset was shown to increase full-length SMN expression from SMN2.	Polyphenols	12-23	survival of motor neuron 2, centromeric	Homo sapiens	105-109
17827443-1	2007	Certain polyphenols inhibit the activity of aromatase, a critical enzyme in estrogen synthesis that is coded by the CYP19A1 gene.	Polyphenols	8-19	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	116-123
18354258-0	2008	Angiotensin II induces the vascular expression of VEGF and MMP-2 in vivo: preventive effect of red wine polyphenols.	Polyphenols	104-115	angiotensinogen	Rattus norvegicus	0-14
18354258-1	2008	OBJECTIVE: Previous investigations have indicated that angiotensin II (Ang II)-induced hypertension and endothelial dysfunction are prevented by intake of red wine polyphenols (RWPs).	Polyphenols	164-175	angiotensinogen	Rattus norvegicus	55-69
18354258-1	2008	OBJECTIVE: Previous investigations have indicated that angiotensin II (Ang II)-induced hypertension and endothelial dysfunction are prevented by intake of red wine polyphenols (RWPs).	Polyphenols	164-175	angiotensinogen	Rattus norvegicus	71-77
19544670-0	2008	Inhibition of Nm23H2 gene product (NDPK-B) by angiostatin, polyphenols and nucleoside analogs.	Polyphenols	59-70	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	14-20
19544670-0	2008	Inhibition of Nm23H2 gene product (NDPK-B) by angiostatin, polyphenols and nucleoside analogs.	Polyphenols	59-70	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	35-41
18437986-4	2008	RESULTS: Three depigmenting agents showed an inhibition effect on the tyrosinase activity of melanocytes and reduced significantly melanin content in the pigmented skin equivalent model, in which the tea polyphenols had the strongest effect, and then was the aloesin.	Polyphenols	204-215	tyrosinase	Homo sapiens	70-80
18437986-6	2008	CONCLUSIONS: All the three depigmenting agents showed a concentration dependent suppression effect on the tyrosinase activity and formation of melanin, in which the tea polyphenols was the strongest effect( P &lt;0.05).	Polyphenols	169-180	tyrosinase	Homo sapiens	106-116
18946510-6	2008	Applying a whole blood assay, IC(50) values of pro-inflammatory cytokine release (TNF-alpha, IL-6, IL-8, IL-1beta) were found to be positively correlated with the K(i)-values of the aforementioned polyphenols.	Polyphenols	197-208	tumor necrosis factor	Homo sapiens	82-91
18946510-6	2008	Applying a whole blood assay, IC(50) values of pro-inflammatory cytokine release (TNF-alpha, IL-6, IL-8, IL-1beta) were found to be positively correlated with the K(i)-values of the aforementioned polyphenols.	Polyphenols	197-208	interleukin 6	Homo sapiens	93-97
18946510-6	2008	Applying a whole blood assay, IC(50) values of pro-inflammatory cytokine release (TNF-alpha, IL-6, IL-8, IL-1beta) were found to be positively correlated with the K(i)-values of the aforementioned polyphenols.	Polyphenols	197-208	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
18946510-6	2008	Applying a whole blood assay, IC(50) values of pro-inflammatory cytokine release (TNF-alpha, IL-6, IL-8, IL-1beta) were found to be positively correlated with the K(i)-values of the aforementioned polyphenols.	Polyphenols	197-208	interleukin 1 beta	Homo sapiens	105-113
17827443-2	2007	Consumption of polyphenol-rich foods and beverages, thus, may interact with CYP19A1 genetic polymorphisms in the development of endometrial cancer.	Polyphenols	15-25	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	76-83
17827443-9	2007	The authors" findings suggest that tea polyphenols may modify the effect of CYP19A1 genetic polymorphisms on the development of endometrial cancer.	Polyphenols	39-50	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	76-83
17628008-2	2007	For example, dietary polyphenols, such as soy isoflavones genistein and daidzein, modulate the activity of the estrogen receptors (ERs)-alpha and ERbeta.	Polyphenols	21-32	estrogen receptor 2 (beta)	Mus musculus	146-152
18089804-0	2007	Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype.	Polyphenols	10-21	REL proto-oncogene, NF-kB subunit	Homo sapiens	50-55
18089804-0	2007	Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype.	Polyphenols	10-21	aryl hydrocarbon receptor	Homo sapiens	81-106
18089804-0	2007	Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype.	Polyphenols	10-21	snail family transcriptional repressor 2	Homo sapiens	108-112
17910019-0	2007	Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols.	Polyphenols	106-117	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	76-85
17716620-2	2007	In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts.	Polyphenols	39-50	tyrosinase	Homo sapiens	124-134
17716620-2	2007	In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts.	Polyphenols	39-50	tyrosinase	Homo sapiens	209-219
17724029-0	2007	Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5"-AMP-activated protein kinase.	Polyphenols	47-57	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	102-133
18059161-10	2007	Focussed microarray analysis and reverse transcriptase polymerase chain reaction and zymogram analysis revealed inhibition of MMP-9 expression by polyphenol treatment.	Polyphenols	146-156	matrix metallopeptidase 9	Homo sapiens	126-131
18059161-11	2007	Furthermore, AKT was found to be inhibited both at the RNA and protein level by polyphenol treatment.	Polyphenols	80-90	AKT serine/threonine kinase 1	Homo sapiens	13-16
17623866-0	2007	Inhibition of Ribonuclease A by polyphenols present in green tea.	Polyphenols	32-43	ribonuclease A family member 1, pancreatic	Homo sapiens	14-28
17623866-3	2007	The dissociation constants range from 50-150 microM for the RNase A-polyphenol complexes as determined by ultraviolet (UV) and circular dichroism (CD) studies.	Polyphenols	68-78	ribonuclease A family member 1, pancreatic	Homo sapiens	60-67
17499741-2	2007	We determined the effect of the polyphenol, resveratrol, on CCR2 and the mechanisms involved.	Polyphenols	32-42	C-C motif chemokine receptor 2	Homo sapiens	60-64
18173118-3	2007	The Eap and Trolox equivalent antioxidant capacity (TEAC) values were found to correlate for polyphenols, which react with the ABTS cation radical in two steps.	Polyphenols	93-104	glutamyl aminopeptidase	Homo sapiens	4-7
17825902-0	2007	Grape polyphenols affect mRNA expression of PGHS-2, TIS11b and FOXO3 in endometrium of heifers under ACTH-induced stress.	Polyphenols	6-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-50
17825902-0	2007	Grape polyphenols affect mRNA expression of PGHS-2, TIS11b and FOXO3 in endometrium of heifers under ACTH-induced stress.	Polyphenols	6-17	ZFP36 ring finger protein like 1	Homo sapiens	52-58
17825902-0	2007	Grape polyphenols affect mRNA expression of PGHS-2, TIS11b and FOXO3 in endometrium of heifers under ACTH-induced stress.	Polyphenols	6-17	forkhead box O3	Homo sapiens	63-68
17825902-0	2007	Grape polyphenols affect mRNA expression of PGHS-2, TIS11b and FOXO3 in endometrium of heifers under ACTH-induced stress.	Polyphenols	6-17	proopiomelanocortin	Homo sapiens	101-105
17825902-5	2007	Moreover, the effect of grape polyphenols in endometrium of heifers, under adrenocorticotropic hormone challenge, is evaluated in terms of transcriptional patterns of genes related to inflammation, oxidative stress and endometrial functions.	Polyphenols	30-41	proopiomelanocortin	Homo sapiens	75-102
17825902-14	2007	An interesting role of polyphenols in modulating the expression levels of PGHS-2 in endometrial tissue and on the activation of TIS11b and SOD2 through c-AMP-dependent signalling was suggested.	Polyphenols	23-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-80
17825902-14	2007	An interesting role of polyphenols in modulating the expression levels of PGHS-2 in endometrial tissue and on the activation of TIS11b and SOD2 through c-AMP-dependent signalling was suggested.	Polyphenols	23-34	ZFP36 ring finger protein like 1	Homo sapiens	128-134
17825902-14	2007	An interesting role of polyphenols in modulating the expression levels of PGHS-2 in endometrial tissue and on the activation of TIS11b and SOD2 through c-AMP-dependent signalling was suggested.	Polyphenols	23-34	superoxide dismutase 2	Homo sapiens	139-143
17825902-14	2007	An interesting role of polyphenols in modulating the expression levels of PGHS-2 in endometrial tissue and on the activation of TIS11b and SOD2 through c-AMP-dependent signalling was suggested.	Polyphenols	23-34	cathelicidin antimicrobial peptide	Homo sapiens	152-157
17560706-11	2007	Thus, it is concluded that the inhibition of oxidative mutagenicity of Bz by plant polyphenols could be due to an inhibitory effect of plant polyphenols on the bioactivating enzymes such as cytochrome P-450 and peroxidase and the chelation of iron present in the cytochrome P-450 in the S9 mix.	Polyphenols	83-94	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	190-221
17560706-11	2007	Thus, it is concluded that the inhibition of oxidative mutagenicity of Bz by plant polyphenols could be due to an inhibitory effect of plant polyphenols on the bioactivating enzymes such as cytochrome P-450 and peroxidase and the chelation of iron present in the cytochrome P-450 in the S9 mix.	Polyphenols	141-152	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	190-221
18476390-0	2007	Bees wax polyphenols as suppressor of CC1--induced oxidative stress in rats.	Polyphenols	9-20	Cardiac cell morphology QTL 1	Rattus norvegicus	38-41
17560072-0	2007	Developing a high-throughput system for the screening of cytochrome P450 1A1--inhibitory polyphenols.	Polyphenols	89-100	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	57-76
17658484-0	2007	Prodelphinidin B-4 3"-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway.	Polyphenols	39-49	prostaglandin-endoperoxide synthase 2	Mus musculus	84-89
17658484-0	2007	Prodelphinidin B-4 3"-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway.	Polyphenols	39-49	nitric oxide synthase 2, inducible	Mus musculus	94-98
17658484-0	2007	Prodelphinidin B-4 3"-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway.	Polyphenols	39-49	mitogen-activated protein kinase kinase kinase 7	Mus musculus	125-129
17540733-0	2007	Differential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenols.	Polyphenols	97-108	integrin subunit alpha M	Homo sapiens	27-32
17540733-2	2007	Earlier studies have demonstrated a role for green tea polyphenols in down-regulating CD11b on CD8(+) T cells and monocytes.	Polyphenols	55-66	integrin subunit alpha M	Homo sapiens	86-91
17540733-2	2007	Earlier studies have demonstrated a role for green tea polyphenols in down-regulating CD11b on CD8(+) T cells and monocytes.	Polyphenols	55-66	CD8a molecule	Homo sapiens	95-98
17540733-9	2007	The APP-induced down-regulation of CD11b on monocytes was inhibited by an anti-CD11b mAb, consistent with previous studies showing that polyphenols bind CD11b.	Polyphenols	136-147	integrin subunit alpha M	Homo sapiens	35-40
17540733-9	2007	The APP-induced down-regulation of CD11b on monocytes was inhibited by an anti-CD11b mAb, consistent with previous studies showing that polyphenols bind CD11b.	Polyphenols	136-147	integrin subunit alpha M	Homo sapiens	79-84
17540733-9	2007	The APP-induced down-regulation of CD11b on monocytes was inhibited by an anti-CD11b mAb, consistent with previous studies showing that polyphenols bind CD11b.	Polyphenols	136-147	integrin subunit alpha M	Homo sapiens	79-84
17785825-4	2007	Natural polyphenols are compounds reported to have therapeutic properties in diseases involving IL-4 and STAT6.	Polyphenols	8-19	interleukin 4	Homo sapiens	96-100
17785825-4	2007	Natural polyphenols are compounds reported to have therapeutic properties in diseases involving IL-4 and STAT6.	Polyphenols	8-19	signal transducer and activator of transcription 6	Homo sapiens	105-110
17597382-0	2007	Transport of a cancer chemopreventive polyphenol, resveratrol: interaction with serum albumin and hemoglobin.	Polyphenols	38-48	albumin	Homo sapiens	80-93
17081606-0	2007	Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg.	Polyphenols	110-120	ELAV like RNA binding protein 1	Homo sapiens	14-17
17081606-0	2007	Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg.	Polyphenols	110-120	matrix metallopeptidase 9	Homo sapiens	22-27
19070082-8	2007	However, simultaneous intubations of some of the rat with 10 mg or 20 mg mL(-1) of T. occidentalis leaf extract (free soluble or bound polyphenols) along side with the acetaminophen caused a significant decrease (p&lt;0.05) in serum ALP, GOT and GPT (except those intubated with bound polyphenols).	Polyphenols	135-146	glutamic--pyruvic transaminase	Rattus norvegicus	246-249
17602962-0	2007	Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase.	Polyphenols	0-11	endothelin 1	Rattus norvegicus	76-88
17636939-0	2007	Interaction of different polyphenols with bovine serum albumin (BSA) and human salivary alpha-amylase (HSA) by fluorescence quenching.	Polyphenols	25-36	albumin	Homo sapiens	49-68
17636939-0	2007	Interaction of different polyphenols with bovine serum albumin (BSA) and human salivary alpha-amylase (HSA) by fluorescence quenching.	Polyphenols	25-36	amylase alpha 1A	Homo sapiens	79-101
17521618-1	2007	Previous studies could demonstrate, that the naturally occuring polyphenol resveratrol inhibits cell growth of colon carcinoma cells at least in part by inhibition of protooncogene ornithine decarboxylase (ODC).	Polyphenols	64-74	ornithine decarboxylase 1	Homo sapiens	181-204
17620095-0	2007	Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model.	Polyphenols	10-20	caspase 14	Mus musculus	29-39
17620095-3	2007	We recently reported that human psoriatic tissues lack normal expression of caspase 14 [J Dermatol Sci37 (2005) 61], and caspase 14 is induced by EGCG, a green tea polyphenol (GTP), in exponentially growing normal human epidermal keratinocytes (NHEK) [J Pharmacol Exp Ther315 (2005) 805].	Polyphenols	164-174	caspase 14	Homo sapiens	121-131
17498676-5	2007	In this review, we highlight that NO and reactive oxygen radicals may mediate dietary polyphenol induced activation of Nrf2, which in turn triggers antioxidant response element (ARE) driven transcription of phase II detoxifying and antioxidant defense enzymes in vascular cells.	Polyphenols	86-96	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
17521618-1	2007	Previous studies could demonstrate, that the naturally occuring polyphenol resveratrol inhibits cell growth of colon carcinoma cells at least in part by inhibition of protooncogene ornithine decarboxylase (ODC).	Polyphenols	64-74	ornithine decarboxylase 1	Homo sapiens	206-209
17637191-6	2007	The findings also suggested that the presence of a large number of galloyl groups in polyphenols strengthens the interaction with regulatory regions in P-gp.	Polyphenols	85-96	ATP binding cassette subfamily B member 1	Homo sapiens	152-156
17381962-0	2007	Carob pulp preparation rich in insoluble dietary fibre and polyphenols increases plasma glucose and serum insulin responses in combination with a glucose load in humans.	Polyphenols	59-70	insulin	Homo sapiens	106-113
17381962-10	2007	In conclusion, we showed that polyphenol-rich carob fibre, administered within a water-glucose solution, increases postprandial glucose and insulin responses, suggesting a deterioration in glycaemic control.	Polyphenols	30-40	insulin	Homo sapiens	140-147
17293380-0	2007	Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1.	Polyphenols	30-41	sulfotransferase family 1A member 1	Homo sapiens	63-90
17539658-0	2007	Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.	Polyphenols	4-14	fatty acid synthase	Homo sapiens	81-100
17539658-0	2007	Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.	Polyphenols	4-14	AKT serine/threonine kinase 1	Homo sapiens	185-188
17503833-0	2007	Interactions between a non glycosylated human proline-rich protein and flavan-3-ols are affected by protein concentration and polyphenol/protein ratio.	Polyphenols	126-136	complement component 4 binding protein alpha	Homo sapiens	46-66
16970955-0	2007	Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fat-enriched diet.	Polyphenols	29-40	C-C motif chemokine ligand 2	Homo sapiens	121-126
16970955-8	2007	Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release.	Polyphenols	54-65	nuclear factor kappa B subunit 1	Homo sapiens	93-102
16970955-8	2007	Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release.	Polyphenols	54-65	C-C motif chemokine ligand 2	Homo sapiens	128-133
16970955-9	2007	CONCLUSION: Consumption of moderate amounts of alcoholic drinks containing polyphenols decreases NF-kappaB activation in PBMCs and MCP-1 plasma levels during a fat-enriched diet.	Polyphenols	75-86	nuclear factor kappa B subunit 1	Homo sapiens	97-106
16970955-9	2007	CONCLUSION: Consumption of moderate amounts of alcoholic drinks containing polyphenols decreases NF-kappaB activation in PBMCs and MCP-1 plasma levels during a fat-enriched diet.	Polyphenols	75-86	C-C motif chemokine ligand 2	Homo sapiens	131-136
17499812-3	2007	In the present study, we report that black tea polyphenol, Theaflavins (TF)-induced apoptosis in human prostate carcinoma, LNCaP cells is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-kappa B activity, causing a change in the ratio of pro-and antiapoptotic proteins leading to apoptosis.	Polyphenols	47-57	tumor protein p53	Homo sapiens	204-207
17499812-3	2007	In the present study, we report that black tea polyphenol, Theaflavins (TF)-induced apoptosis in human prostate carcinoma, LNCaP cells is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-kappa B activity, causing a change in the ratio of pro-and antiapoptotic proteins leading to apoptosis.	Polyphenols	47-57	nuclear factor kappa B subunit 1	Homo sapiens	231-241
17363366-0	2007	Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.	Polyphenols	38-48	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	172-175
17227956-1	2007	Epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea, may augment metabolic and vascular actions of insulin.	Polyphenols	45-55	insulin	Homo sapiens	116-123
17478321-2	2007	We have shown that alcohol and individual polyphenols modulate EC fibrinolytic protein (t-PA, u-PA, PAI-1, u-PAR and Annexin-II) expression at the cellular, molecular, and gene levels to sustain increased fibrinolytic activity.	Polyphenols	42-53	promotion susceptibility QTL 1	Mus musculus	88-92
17478321-2	2007	We have shown that alcohol and individual polyphenols modulate EC fibrinolytic protein (t-PA, u-PA, PAI-1, u-PAR and Annexin-II) expression at the cellular, molecular, and gene levels to sustain increased fibrinolytic activity.	Polyphenols	42-53	proline-rich acidic protein 1	Mus musculus	94-98
17478321-2	2007	We have shown that alcohol and individual polyphenols modulate EC fibrinolytic protein (t-PA, u-PA, PAI-1, u-PAR and Annexin-II) expression at the cellular, molecular, and gene levels to sustain increased fibrinolytic activity.	Polyphenols	42-53	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	100-105
17478321-2	2007	We have shown that alcohol and individual polyphenols modulate EC fibrinolytic protein (t-PA, u-PA, PAI-1, u-PAR and Annexin-II) expression at the cellular, molecular, and gene levels to sustain increased fibrinolytic activity.	Polyphenols	42-53	plasminogen activator, urokinase receptor	Mus musculus	107-112
17478321-2	2007	We have shown that alcohol and individual polyphenols modulate EC fibrinolytic protein (t-PA, u-PA, PAI-1, u-PAR and Annexin-II) expression at the cellular, molecular, and gene levels to sustain increased fibrinolytic activity.	Polyphenols	42-53	annexin A2	Mus musculus	117-127
17215118-1	2007	Three amperometric biosensors based on immobilization of tyrosinase on a new Sonogel-Carbon electrode for detection of phenols and polyphenols are described.	Polyphenols	131-142	tyrosinase	Homo sapiens	57-67
17258915-5	2007	Furthermore, tea polyphenols transduced the apoptosis signal via generation of reactive oxygen species and decrease in the Bcl-2/Bax ratio thereby inducing mitochondrial permeability transition with consequent activation of caspase-3.	Polyphenols	17-28	BCL2 apoptosis regulator	Homo sapiens	123-128
17258915-5	2007	Furthermore, tea polyphenols transduced the apoptosis signal via generation of reactive oxygen species and decrease in the Bcl-2/Bax ratio thereby inducing mitochondrial permeability transition with consequent activation of caspase-3.	Polyphenols	17-28	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
17258915-5	2007	Furthermore, tea polyphenols transduced the apoptosis signal via generation of reactive oxygen species and decrease in the Bcl-2/Bax ratio thereby inducing mitochondrial permeability transition with consequent activation of caspase-3.	Polyphenols	17-28	caspase 3	Homo sapiens	224-233
17637178-10	2007	Whereas most unmethylated polyphenols, such as curcumin and quercetin, have very poor bioavailability, the high metabolic stability of the methoxylated flavones studied here suggests that these CYP1B1 inhibitors may also be effective in-vivo.	Polyphenols	26-37	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	194-200
17458979-3	2007	However, polyphenols, except for procyanidin, in AP (i.e., catechins, chalcones, and phenol carboxylic acids) showed weak inhibitory activities on pancreatic lipase.	Polyphenols	9-20	pancreatic lipase	Homo sapiens	147-164
17070989-6	2007	Polyphenol treatment decreased ROS generation and downregulated MMP-9 expression.	Polyphenols	0-10	matrix metallopeptidase 9	Mus musculus	64-69
17070989-8	2007	Our data suggest, that polyphenols inhibit cell shedding and invasion by their anti-oxidative capacity and downregulation of MMP-9 expression.	Polyphenols	23-34	matrix metallopeptidase 9	Mus musculus	125-130
17293380-7	2007	For all polyphenols investigated, "normal-activity" SULT1A1*1 allozyme had significantly greater Vmax estimates than SULT1E1, and allele-specific differences in SULT1A1-mediated sulfation were observed.	Polyphenols	8-19	sulfotransferase family 1A member 1	Homo sapiens	52-59
17485788-1	2007	AIM: To examine the anti-inflammatory effects of green tea polyphenols on oxLDL-mediated TNFalpha expression and NF-KB activation in the human umbilical vein endothelial cells (HUVECs).	Polyphenols	59-70	tumor necrosis factor	Homo sapiens	89-97
17427262-0	2007	Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells.	Polyphenols	6-17	epidermal growth factor receptor	Homo sapiens	54-86
17134953-3	2007	The aim of this study was to investigate whether resveratrol (RES), an antioxidant polyphenol of red wine, can influence the activity of PPARalpha in the rat hepatoma cell line McArdle-RH7777.	Polyphenols	83-93	peroxisome proliferator activated receptor alpha	Rattus norvegicus	137-146
17372168-2	2007	We hypothesized that in vivo stabilization of aortic elastin with pentagalloyl glucose (PGG), an elastin-binding polyphenol, would interfere with AAA development.	Polyphenols	113-123	elastin	Rattus norvegicus	53-60
17372168-2	2007	We hypothesized that in vivo stabilization of aortic elastin with pentagalloyl glucose (PGG), an elastin-binding polyphenol, would interfere with AAA development.	Polyphenols	113-123	elastin	Rattus norvegicus	97-104
17485788-2	2007	METHODS: We postulate that green tea polyphenols regulate TNF-alpha gene expression by modulating NF-KB activation through their inhibition effect on IKB Kinase (IKK) activity and as scavenger of free radicals.	Polyphenols	37-48	tumor necrosis factor	Homo sapiens	58-67
17485788-3	2007	Pretreatment of green tea polyphenols reduced oxLDL-induced production of proinflammatory cytokine TNF-alpha and NF-KB activation in dose dependent manner (p &lt; 0.05).	Polyphenols	26-37	tumor necrosis factor	Homo sapiens	99-108
17485788-6	2007	The effect of green tea polyphenols on TNF-alpha expression were determined by Mann-Whitney test.	Polyphenols	24-35	tumor necrosis factor	Homo sapiens	39-48
17485788-9	2007	In this study, green tea polyphenols showed significant effects on the inhibition of TNF-alpha through NF-KB activation pathway in HUVECs with oxidized LDL.	Polyphenols	25-36	tumor necrosis factor	Homo sapiens	85-94
17523930-3	2007	Cacao bean and cola nut are popular edible plants that contain polyphenols and xanthine derivatives.	Polyphenols	63-74	NUT midline carcinoma, family member 1	Mus musculus	20-23
16860979-9	2007	CEACAM1, with a significant regulatory role on cell proliferation of particular interest at early stages of cancer development, may be a potential target for chemoprevention by food components such as those present in polyphenol-rich fruits.	Polyphenols	218-228	CEA cell adhesion molecule 1	Homo sapiens	0-7
17164435-4	2007	To investigate whether green tea polyphenols have an effect on the regulation of adiponectin, we measured expression and secretion levels of adiponectin protein after treatment of each green tea polyphenols in 3T3-L1 adipocytes.	Polyphenols	33-44	adiponectin, C1Q and collagen domain containing	Mus musculus	81-92
17369354-1	2007	Green tea polyphenol, epigallocatechin-3-gallate (EGCG) differentially regulates the cellular growth of cancer cells in a p53-dependent manner through apoptosis and/or cell cycle arrest.	Polyphenols	10-20	transformation related protein 53, pseudogene	Mus musculus	122-125
17372258-4	2007	We showed that the tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), is a small-molecule inhibitor of IGF-IR activity (IC50 of 14 micromol/L).	Polyphenols	23-33	insulin like growth factor 1 receptor	Homo sapiens	107-113
17374166-0	2007	The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases.	Polyphenols	109-120	interleukin 6	Homo sapiens	4-17
17364504-0	2007	Green tea polyphenols reduce autoimmune symptoms in a murine model for human Sjogren"s syndrome and protect human salivary acinar cells from TNF-alpha-induced cytotoxicity.	Polyphenols	10-21	tumor necrosis factor	Homo sapiens	141-150
17316549-0	2007	Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes.	Polyphenols	21-32	zinc finger protein 36	Mus musculus	58-73
17316549-0	2007	Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes.	Polyphenols	21-32	insulin receptor	Mus musculus	75-91
17332308-7	2007	In vivo, combination treatment with green tea polyphenols and celecoxib resulted in enhanced (a) tumor growth inhibition, (b) lowering of prostate-specific antigen levels, (c) lowering of insulin-like growth factor-I levels, and (d) circulating levels of serum insulin-like growth factor binding protein-3 compared with results of single-agent treatment.	Polyphenols	46-57	insulin like growth factor binding protein 3	Homo sapiens	261-305
17379280-12	2007	Polyphenols repress EC PAI-1 expression, in part, by activating ERK and JNK signaling pathways and this repression is at transcriptional levels.	Polyphenols	0-11	mitogen-activated protein kinase 8	Homo sapiens	72-75
17364965-0	2007	Inhibition of ozone-induced SP-A oxidation by plant polyphenols.	Polyphenols	52-63	surfactant protein A1	Homo sapiens	28-32
17364965-3	2007	In the present study, eight plant polyphenols (three flavonoids, three hydroxycinnamic acids, and two hydroxybenzoic acids) known as strong antioxidants, were tested for their ability to inhibit ozone-induced SP-A oxidation as a mechanism for chemoprevention against lung damage.	Polyphenols	34-45	surfactant protein A1	Homo sapiens	209-213
17364965-9	2007	The results indicate that inhibition of SP-A oxidation by plant polyphenols may be a mechanism accounting for the protective activity of natural antioxidants against the effects of ozone exposure on lungs.	Polyphenols	64-75	surfactant protein A1	Homo sapiens	40-44
17278969-0	2007	Activation of endothelial nitric oxide synthase by red wine polyphenols: impact of grape cultivars, growing area and the vinification process.	Polyphenols	60-71	nitric oxide synthase 3	Homo sapiens	14-47
17278969-3	2007	The aim of the present study was to elucidate the impact of grape cultivars, growing area and the vinification/fermentation process on the ability of red wine polyphenol extracts to increase human endothelial nitric oxide synthase (eNOS) promotor and enzyme activity.	Polyphenols	159-169	nitric oxide synthase 3	Homo sapiens	197-230
17278969-3	2007	The aim of the present study was to elucidate the impact of grape cultivars, growing area and the vinification/fermentation process on the ability of red wine polyphenol extracts to increase human endothelial nitric oxide synthase (eNOS) promotor and enzyme activity.	Polyphenols	159-169	nitric oxide synthase 3	Homo sapiens	232-236
17278969-4	2007	METHODS: We produced polyphenol extracts from a variety of red wines from all over the world and tested their influence on eNOS promotor activity by a luciferase reporter gene assay.	Polyphenols	21-31	nitric oxide synthase 3	Homo sapiens	123-127
17135264-0	2007	Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.	Polyphenols	30-40	B cell leukemia/lymphoma 2	Mus musculus	49-54
17135264-3	2007	However, the molecular mechanism(s) linking polyphenol signaling and bcl-2 expression are unknown.	Polyphenols	44-54	B cell leukemia/lymphoma 2	Mus musculus	69-74
16862172-0	2007	Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells.	Polyphenols	10-20	nuclear factor kappa B subunit 1	Homo sapiens	72-81
17223694-5	2007	Dimer formation does not prevent tight binding of ligands to the hydrophobic cleft of BCL-xL; however, binding of a BID BH3-peptide or a polyphenol drug, gossypol, to BCL-xL significantly slowed monomer-dimer interconversion and is an example of the control of BCL protein oligomerization by ligand binding.	Polyphenols	137-147	BCL2 like 1	Homo sapiens	167-173
17049256-4	2007	In particular, this routine assay was used to examine the effects of stilbenes, a well-known polyphenol class, as inhibitors of Abeta fibril formation.	Polyphenols	93-103	amyloid beta precursor protein	Homo sapiens	128-133
17014826-2	2007	It is the first investigation of the effect of a green tea polyphenol, (-)-epigallocatechin gallate (EGCG), on the PGE(2)-producing microsomal prostaglandin E synthase 1 (mPGES-1) expression in the lung alveolar type II pneumocytes, A549 cells as an epithelial model.	Polyphenols	59-69	prostaglandin E synthase	Homo sapiens	132-169
17014826-2	2007	It is the first investigation of the effect of a green tea polyphenol, (-)-epigallocatechin gallate (EGCG), on the PGE(2)-producing microsomal prostaglandin E synthase 1 (mPGES-1) expression in the lung alveolar type II pneumocytes, A549 cells as an epithelial model.	Polyphenols	59-69	prostaglandin E synthase	Mus musculus	171-178
17317271-0	2007	Glucuronide transport across the endoplasmic reticulum membrane is inhibited by epigallocatechin gallate and other green tea polyphenols.	Polyphenols	125-136	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	121-124
17182830-1	2007	Certain dietary polyphenols, such as (-)-epigallocatechin 3-gallate (EGCG) from green tea and genistein from soybean, have been demonstrated to inhibit DNA methyltransferases (DNMT) in vitro.	Polyphenols	16-27	DNA methyltransferase 1	Homo sapiens	176-180
17182830-5	2007	Catechol polyphenols may indirectly inhibit DNMT by generating S-adenosyl-L-homocysteine on their methylation by S-adenosyl-L-methionine.	Polyphenols	9-20	DNA methyltransferase 1	Homo sapiens	44-48
17189836-0	2007	Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector?	Polyphenols	21-32	membrane bound transcription factor peptidase, site 1	Homo sapiens	14-17
17189836-0	2007	Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector?	Polyphenols	21-32	nuclear factor kappa B subunit 1	Homo sapiens	73-81
17189837-0	2007	Inhibition of S1P-induced angiogenesis, metastasis and inflammation by dietary polyphenols.	Polyphenols	79-90	membrane bound transcription factor peptidase, site 1	Homo sapiens	14-17
17174037-1	2007	BACKGROUND: The aim of our study has to evaluate the antiproliferative effect of polyphenols and sterols extracted from the virgin argan oil on three human prostatic cell lines (DU145, LNCaP, and PC3).	Polyphenols	81-92	chromobox 8	Homo sapiens	196-199
17683969-1	2007	We demonstrate that the tea polyphenol, epigallocatechin-3-gallate, is an efficient inhibitor of human dihydrofolate reductase.	Polyphenols	28-38	dihydrofolate reductase	Homo sapiens	103-126
17379280-0	2007	Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection.	Polyphenols	0-11	serpin family E member 1	Homo sapiens	25-30
17379280-3	2007	This study determined whether polyphenols (catechin and quercetin) activated kinase-signaling cascades that suppress PAI-1 expression and whether this suppression is at the transcription level in human coronary artery endothelial cells (ECs) remains unresolved.	Polyphenols	30-41	serpin family E member 1	Homo sapiens	117-122
17379280-8	2007	These polyphenols activated EC p38 and ERK1/2 within 2.5 and 5 min, respectively, while maximal JNK activation occurred at 10-15 min.	Polyphenols	6-17	mitogen-activated protein kinase 1	Homo sapiens	31-34
17379280-8	2007	These polyphenols activated EC p38 and ERK1/2 within 2.5 and 5 min, respectively, while maximal JNK activation occurred at 10-15 min.	Polyphenols	6-17	mitogen-activated protein kinase 3	Homo sapiens	39-45
17379280-10	2007	Inhibitors of ERK or JNK prevented polyphenol repression of EC PAI-1 gene expression.	Polyphenols	35-45	mitogen-activated protein kinase 3	Homo sapiens	14-17
17379280-10	2007	Inhibitors of ERK or JNK prevented polyphenol repression of EC PAI-1 gene expression.	Polyphenols	35-45	mitogen-activated protein kinase 8	Homo sapiens	21-24
17379280-10	2007	Inhibitors of ERK or JNK prevented polyphenol repression of EC PAI-1 gene expression.	Polyphenols	35-45	serpin family E member 1	Homo sapiens	63-68
17379280-12	2007	Polyphenols repress EC PAI-1 expression, in part, by activating ERK and JNK signaling pathways and this repression is at transcriptional levels.	Polyphenols	0-11	serpin family E member 1	Homo sapiens	23-28
17379280-12	2007	Polyphenols repress EC PAI-1 expression, in part, by activating ERK and JNK signaling pathways and this repression is at transcriptional levels.	Polyphenols	0-11	mitogen-activated protein kinase 3	Homo sapiens	64-67
17379280-13	2007	Thus MAPK seem to play an important role in polyphenol-induce repression of PAI-1 expression in ECs.	Polyphenols	44-54	mitogen-activated protein kinase 3	Homo sapiens	5-9
17379280-13	2007	Thus MAPK seem to play an important role in polyphenol-induce repression of PAI-1 expression in ECs.	Polyphenols	44-54	serpin family E member 1	Homo sapiens	76-81
17341611-5	2006	Besides small peptides and oligonucleotides, numerous small molecules have been identified as blockers of STAT3 activation, including synthetic molecules (e.g., AG 490, decoy peptides, and oligonucleotides) and plant polyphenols (e.g., curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, EGCG, and cucurbitacin).	Polyphenols	217-228	signal transducer and activator of transcription 3	Homo sapiens	106-111
17177569-0	2006	Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols.	Polyphenols	113-124	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
17147439-7	2006	All four polyphenols had higher relative affinities for proline-rich proteins than for bovine serum albumin.	Polyphenols	9-20	albumin	Homo sapiens	94-107
17131458-0	2006	Intervention with polyphenol-rich fruit juices results in an elevation of glutathione S-transferase P1 (hGSTP1) protein expression in human leucocytes of healthy volunteers.	Polyphenols	18-28	glutathione S-transferase pi 1	Homo sapiens	74-102
17157668-0	2006	Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: Potential for HIV-1 therapy.	Polyphenols	35-45	CD4 molecule	Homo sapiens	90-93
17131458-0	2006	Intervention with polyphenol-rich fruit juices results in an elevation of glutathione S-transferase P1 (hGSTP1) protein expression in human leucocytes of healthy volunteers.	Polyphenols	18-28	glutathione S-transferase pi 1	Homo sapiens	104-110
17131458-2	2006	We investigated the hypothesis that polyphenols enhance expression of glutathione S-transferases (GSTs), which increases carcinogen detoxification and thereby provides protection against oxidative stress.	Polyphenols	36-47	glutathione S-transferase mu 1	Homo sapiens	98-102
17131458-14	2006	In vivo, however, we observed a delayed enhancement of hGSTP1, which could be associated with an initial repression of oxidative DNA damage in leucocytes from human subjects, consuming juices with high levels of polyphenols.	Polyphenols	212-223	glutathione S-transferase pi 1	Homo sapiens	55-61
17016632-11	2006	Tea extracts and polyphenols significantly altered the oxidative status of G6PD-deficient erythrocytes in vitro as demonstrated by the decrease of GSH, and increased GSSG, methemoglobin and plasma hemoglobin.	Polyphenols	17-28	hemoglobin subunit gamma 2	Homo sapiens	172-185
16934760-2	2006	A number of plant polyphenols including curcumin, a yellow compound in the spice turmeric, have been shown to inhibit the activation of AP-1.	Polyphenols	18-29	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
16921400-1	2006	BACKGROUND AND PURPOSE: Red wine polyphenols (RWPs) inhibit the expression of vascular endothelial growth factor (VEGF), a major pro-angiogenic and pro-atherosclerotic factor, in vascular smooth muscle cells (VSMCs).	Polyphenols	33-44	vascular endothelial growth factor A	Homo sapiens	78-112
16682945-6	2006	Nutrients, which are considered to be chemoprotective with respect to colon cancer development, including butyrate, green tea and apple polyphenols, had the capacity to elevate transcription of endogenous DEP-1 mRNA and expression of DEP-1 protein.	Polyphenols	136-147	protein tyrosine phosphatase receptor type J	Homo sapiens	205-210
16682945-6	2006	Nutrients, which are considered to be chemoprotective with respect to colon cancer development, including butyrate, green tea and apple polyphenols, had the capacity to elevate transcription of endogenous DEP-1 mRNA and expression of DEP-1 protein.	Polyphenols	136-147	protein tyrosine phosphatase receptor type J	Homo sapiens	234-239
17250449-0	2006	Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression.	Polyphenols	10-21	cytochrome c oxidase II, mitochondrial	Mus musculus	103-108
17250449-0	2006	Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression.	Polyphenols	10-21	caspase 3	Mus musculus	126-135
16921400-1	2006	BACKGROUND AND PURPOSE: Red wine polyphenols (RWPs) inhibit the expression of vascular endothelial growth factor (VEGF), a major pro-angiogenic and pro-atherosclerotic factor, in vascular smooth muscle cells (VSMCs).	Polyphenols	33-44	vascular endothelial growth factor A	Homo sapiens	114-118
16822492-0	2006	Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase.	Polyphenols	9-20	angiotensinogen	Rattus norvegicus	29-43
16890209-0	2006	Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea.	Polyphenols	119-129	MYD88 innate immune signal transduction adaptor	Homo sapiens	15-20
16890209-0	2006	Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea.	Polyphenols	119-129	TIR domain containing adaptor molecule 1	Homo sapiens	26-30
16968061-5	2006	A polyphenol-rich apple juice extract (AE02) was found to effectively inhibit the kinase activity of GSK3beta, immunoprecipitated from HT29 cells.	Polyphenols	2-12	glycogen synthase kinase 3 beta	Homo sapiens	101-109
16964415-5	2006	Here, we report that, while methylation has no effect on nucleophilic susceptibility of (-)-EGCG and (-)-ECG, it may disrupt the ability of these polyphenols to interact with Thr 1 of the proteasome beta5 subunit.	Polyphenols	146-157	thyroid hormone receptor beta	Homo sapiens	175-180
16893904-3	2006	Here, we demonstrate that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) potently inhibits the aggregation of mutant htt exon 1 protein in a dose-dependent manner.	Polyphenols	40-50	huntingtin	Homo sapiens	133-136
16822492-2	2006	This study examined whether red wine polyphenols prevent the angiotensin II (Ang II)-induced hypertension and endothelial dysfunction in rats, and, if so, to elucidate the underlying mechanism.	Polyphenols	37-48	angiotensinogen	Rattus norvegicus	61-75
16822492-2	2006	This study examined whether red wine polyphenols prevent the angiotensin II (Ang II)-induced hypertension and endothelial dysfunction in rats, and, if so, to elucidate the underlying mechanism.	Polyphenols	37-48	angiotensinogen	Rattus norvegicus	77-83
16822492-9	2006	Intake of red wine polyphenols prevented the Ang II-induced hypertension and endothelial dysfunction and normalized vascular superoxide anion production and NADPH oxidase subunit expression.	Polyphenols	19-30	angiotensinogen	Rattus norvegicus	45-51
16822492-11	2006	CONCLUSION: Intake of red wine polyphenols prevents Ang II-induced hypertension and endothelial dysfunction.	Polyphenols	31-42	angiotensinogen	Rattus norvegicus	52-58
15991261-6	2006	Aqueous black tea extract was given as a pretreatment to group IV mice at a dose of 200 mg ml(-1) polyphenols before the pesticide dose, which significantly decreased the levels of lipid peroxidation and significantly elevated the activities of SOD, CAT, GSH, total thiol, GPx, GR and GST in liver to levels similar to the controls.	Polyphenols	98-109	catalase	Mus musculus	250-253
16926505-1	2006	Phenolic acids such as p-coumaric acid and microbial metabolites of poorly absorbed polyphenols are absorbed by the monocarboxylic acid transporter (MCT)-mediated transport system which is identical to the fluorescein/H(+) cotransport system.	Polyphenols	84-95	solute carrier family 16 member 1	Homo sapiens	116-147
16926505-1	2006	Phenolic acids such as p-coumaric acid and microbial metabolites of poorly absorbed polyphenols are absorbed by the monocarboxylic acid transporter (MCT)-mediated transport system which is identical to the fluorescein/H(+) cotransport system.	Polyphenols	84-95	solute carrier family 16 member 1	Homo sapiens	149-152
16873680-0	2006	Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice.	Polyphenols	0-11	low density lipoprotein receptor	Mus musculus	118-130
16873680-2	2006	In HepG2 hepatocytes, polyphenols, including resveratrol (a major polyphenol in red wine), apigenin, and S17834 (a synthetic polyphenol), increased phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), and they increased activity of AMPK with 200 times the potency of metformin.	Polyphenols	22-33	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	167-171
16873680-2	2006	In HepG2 hepatocytes, polyphenols, including resveratrol (a major polyphenol in red wine), apigenin, and S17834 (a synthetic polyphenol), increased phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), and they increased activity of AMPK with 200 times the potency of metformin.	Polyphenols	22-33	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	260-264
16873680-2	2006	In HepG2 hepatocytes, polyphenols, including resveratrol (a major polyphenol in red wine), apigenin, and S17834 (a synthetic polyphenol), increased phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), and they increased activity of AMPK with 200 times the potency of metformin.	Polyphenols	22-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	167-171
16873680-2	2006	In HepG2 hepatocytes, polyphenols, including resveratrol (a major polyphenol in red wine), apigenin, and S17834 (a synthetic polyphenol), increased phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), and they increased activity of AMPK with 200 times the potency of metformin.	Polyphenols	22-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	260-264
16873680-3	2006	The polyphenols also prevented the lipid accumulation that occurred in HepG2 cells exposed to high glucose, and their ability to do so was mimicked and abrogated, respectively, by overexpression of constitutively active and dominant-negative AMPK mutants.	Polyphenols	4-15	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	242-246
16873680-5	2006	These studies 1) reveal that inactivation of hepatic AMPK is a key event in the pathogenesis of hyperlipidemia in diabetes, 2) point to a novel mechanism of action of polyphenols to lower lipids by activating AMPK, and 3) emphasize a new therapeutic avenue to benefit hyperlipidemia and atherosclerosis specifically in diabetes via activating AMPK.	Polyphenols	167-178	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	53-57
16873680-5	2006	These studies 1) reveal that inactivation of hepatic AMPK is a key event in the pathogenesis of hyperlipidemia in diabetes, 2) point to a novel mechanism of action of polyphenols to lower lipids by activating AMPK, and 3) emphasize a new therapeutic avenue to benefit hyperlipidemia and atherosclerosis specifically in diabetes via activating AMPK.	Polyphenols	167-178	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	209-213
16873680-5	2006	These studies 1) reveal that inactivation of hepatic AMPK is a key event in the pathogenesis of hyperlipidemia in diabetes, 2) point to a novel mechanism of action of polyphenols to lower lipids by activating AMPK, and 3) emphasize a new therapeutic avenue to benefit hyperlipidemia and atherosclerosis specifically in diabetes via activating AMPK.	Polyphenols	167-178	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	209-213
16819905-8	2006	These findings suggest that cocoa tea has hypolipemic activity, which may be due to the suppression of digestive lipase activity by the polyphenols contained within the tea.	Polyphenols	136-147	lipase	Theobroma cacao	113-119
16819906-0	2006	Acute effect of tea, wine, beer, and polyphenols on ecto-alkaline phosphatase activity in human vascular smooth muscle cells.	Polyphenols	37-48	tripartite motif containing 33	Homo sapiens	52-56
16819906-0	2006	Acute effect of tea, wine, beer, and polyphenols on ecto-alkaline phosphatase activity in human vascular smooth muscle cells.	Polyphenols	37-48	alkaline phosphatase, placental	Homo sapiens	57-77
16819906-7	2006	All polyphenols tested inhibited ecto-ALP activity, in a concentration-dependent way.	Polyphenols	4-15	tripartite motif containing 33	Homo sapiens	33-37
16819906-7	2006	All polyphenols tested inhibited ecto-ALP activity, in a concentration-dependent way.	Polyphenols	4-15	alkaline phosphatase, placental	Homo sapiens	38-41
16819906-8	2006	Teas, wines, and beers also inhibited ecto-ALP activity, largely according to their polyphenol content.	Polyphenols	84-94	tripartite motif containing 33	Homo sapiens	38-42
16819906-8	2006	Teas, wines, and beers also inhibited ecto-ALP activity, largely according to their polyphenol content.	Polyphenols	84-94	alkaline phosphatase, placental	Homo sapiens	43-46
16819906-11	2006	Although more studies must be done, the inhibition of AALTR ecto-ALP activity by polyphenolic compounds and polyphenol-containing beverages may contribute to their cardiovascular protective effects.	Polyphenols	81-91	tripartite motif containing 33	Homo sapiens	60-64
16819906-11	2006	Although more studies must be done, the inhibition of AALTR ecto-ALP activity by polyphenolic compounds and polyphenol-containing beverages may contribute to their cardiovascular protective effects.	Polyphenols	81-91	alkaline phosphatase, placental	Homo sapiens	65-68
16484233-10	2006	Most importantly, western blotting showed all three polyphenols dramatically reducing BaP-induced CYP1A1 protein expression.	Polyphenols	52-63	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-104
16858288-11	2006	Treatment of quarter-size grafts with radical scavenging C. sinenesis polyphenols (20 microg/ml) increased BrdU labeling and weight gain to 35% and 56%, respectively, reversed inhibition of CyD1 expression, c-Jun phosphorylation, and AP-1 activation in quarter-size grafts compared to half-size grafts, and restored ATP levels to 75%.	Polyphenols	70-81	cyclin D1	Rattus norvegicus	190-194
15991261-6	2006	Aqueous black tea extract was given as a pretreatment to group IV mice at a dose of 200 mg ml(-1) polyphenols before the pesticide dose, which significantly decreased the levels of lipid peroxidation and significantly elevated the activities of SOD, CAT, GSH, total thiol, GPx, GR and GST in liver to levels similar to the controls.	Polyphenols	98-109	hematopoietic prostaglandin D synthase	Mus musculus	285-288
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Polyphenols	76-86	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16463383-0	2006	Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene.	Polyphenols	10-20	DNA damage inducible transcript 3	Homo sapiens	117-124
16815818-3	2006	Green tea polyphenol, epigallocatechin gallate, quercetin, and rutin can reduce the co-oxidation reaction speed of tested compounds mediated by soybean lipoxygenase and the production of oxidative products and free radical intermediates.	Polyphenols	10-20	linoleate 9S-lipoxygenase-4	Glycine max	152-164
16678799-5	2006	Curcumin, a polyphenol found in the plant Curcuma longa, has been shown to suppress the activation of NF-kappaB induced by various pro-inflammatory stimuli by inhibiting IKKbeta kinase activity in MyD88-dependent pathway.	Polyphenols	12-22	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	170-177
16813520-13	2006	Treatment with the plant polyphenol resveratrol as well as isonicotinamide, both of which activate Sirt1, blocked adipocyte development and increased the expression of osteoblast markers.	Polyphenols	25-35	sirtuin 1	Rattus norvegicus	99-104
16772435-0	2006	Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro.	Polyphenols	16-27	low density lipoprotein receptor	Homo sapiens	71-83
16772435-1	2006	Red grape juice (RGJ) polyphenols have been shown to reduce circulating levels of LDL cholesterol and to increase LDL receptor activity.	Polyphenols	22-33	low density lipoprotein receptor	Homo sapiens	114-126
16603228-0	2006	SIRT1 stimulation by polyphenols is affected by their stability and metabolism.	Polyphenols	21-32	sirtuin 1	Homo sapiens	0-5
16603228-2	2006	Dietary polyphenols, abundant in vegetables, fruits, cereals, wine and tea, were reported to stimulate the deacetylase activity of recombinant SIRT1 protein and could therefore be potential regulators of aging associated processes.	Polyphenols	8-19	sirtuin 1	Homo sapiens	143-148
16603228-8	2006	This study shows that the stimulation of SIRT1 is strongly affected by polyphenol stability and metabolism, therefore extrapolation of in vitro SIRT1 stimulation results to physiological effects should be done with caution.	Polyphenols	71-81	sirtuin 1	Homo sapiens	41-46
16733047-2	2006	Previous study reported that the neuroprotective effects of green tea polyphenols against MPP(+)-induced neurotoxicity were related to its inhibitory effect on MPP(+) uptake via DAT in dopaminergic cells.	Polyphenols	70-81	solute carrier family 6 member 3	Rattus norvegicus	178-181
16772446-0	2006	Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
16772446-2	2006	The objective of this study was to determine the bioavailability and bioactivity of tea polyphenols (PP) and theaflavins in human serum and human and mouse tissues.	Polyphenols	88-99	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	84-87
16755003-0	2006	Inhibition of IL-8 production by green tea polyphenols in human nasal fibroblasts and A549 epithelial cells.	Polyphenols	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16624814-1	2006	Recently, we have shown that green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) exerts a beneficial role on reducing brain Abeta levels, resulting in mitigation of cerebral amyloidosis in a mouse model of Alzheimer disease.	Polyphenols	39-49	amyloid beta (A4) precursor protein	Mus musculus	131-136
16527409-3	2006	NMR and molecular modeling studies were performed to investigate the influence of the bulk, flexibility and hydrophobicity of polyphenols on the association with bradykinin, the peptide model.	Polyphenols	126-137	kininogen 1	Homo sapiens	162-172
16755003-8	2006	Tea polyphenols were very effective in the inhibition of IL-8 production.	Polyphenols	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
16755003-11	2006	Production of IL-8 after stimulation by proinflammatory cytokines in both nasal fibroblasts and bronchial epithelial cells was significantly blocked by pretreatment with green tea polyphenols.	Polyphenols	180-191	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16243419-4	2006	Compared with untreated control group, polyphenols (100 microg/ml) reduced the expression of Bcl-2 whereas those of Bax and Caspase-3 were increased.	Polyphenols	39-50	BCL2 apoptosis regulator	Homo sapiens	93-98
16770007-10	2006	This effect, resulting in NO-mediated platelet glycoprotein GpIIb/IIIa down-regulation, could provide a novel mechanism through which polyphenols reduce cardiovascular disease.	Polyphenols	134-145	integrin subunit alpha 2b	Homo sapiens	60-65
16639703-3	2006	The proposed method permits the identification of hop polyphenols (flavonoids glycosides and chalcones), bitter acids (alpha-acids and beta-acids), and their oxidation products.	Polyphenols	54-65	HOP homeobox	Homo sapiens	50-53
16243419-5	2006	The Caspase-3 activity in the polyphenols treated group was significantly increased compared to those in control group (P&lt;0.05).	Polyphenols	30-41	caspase 3	Homo sapiens	4-13
16601672-4	2006	Results of a pulse and chase experiment showed that pretreatment with both polyphenols enhanced biostability of tropoelastin and newly deposited elastin.	Polyphenols	75-86	elastin	Homo sapiens	112-124
16601672-4	2006	Results of a pulse and chase experiment showed that pretreatment with both polyphenols enhanced biostability of tropoelastin and newly deposited elastin.	Polyphenols	75-86	elastin	Homo sapiens	117-124
16601672-5	2006	Results of in vitro assays indicated that both polyphenols bound to purified elastin and significantly decreased its proteolytic degradation by elastolytic enzymes belonging to the serine proteinase, cysteine proteinase, and metallo-proteinase families.	Polyphenols	47-58	elastin	Homo sapiens	77-84
16698588-0	2006	Tea polyphenols inhibit expressions of iNOS and TNF-alpha and prevent lipopolysaccharide-induced liver injury in rats.	Polyphenols	4-15	nitric oxide synthase 2	Rattus norvegicus	39-43
16681381-3	2006	Several polyphenols, phenothiazines, porphyrins, polyene macrolides, and Congo red and its derivatives, BSB and FSB, inhibited alpha-synuclein filament assembly with IC(50) values in the low micromolar range.	Polyphenols	8-19	synuclein alpha	Homo sapiens	127-142
15975707-0	2006	The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells.	Polyphenols	8-19	telomerase reverse transcriptase	Homo sapiens	66-98
15975707-0	2006	The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells.	Polyphenols	8-19	telomerase reverse transcriptase	Homo sapiens	100-105
16698588-0	2006	Tea polyphenols inhibit expressions of iNOS and TNF-alpha and prevent lipopolysaccharide-induced liver injury in rats.	Polyphenols	4-15	tumor necrosis factor	Rattus norvegicus	48-57
16698588-1	2006	BACKGROUND: Tea polyphenols have been shown to protect against carbon tetrachloride (CCl4)-induced liver injury, liver fibrosis, hepatic ischemia-reperfusion injury.	Polyphenols	16-27	C-C motif chemokine ligand 4	Rattus norvegicus	85-89
16698588-9	2006	Pretreatment with tea polyphenols attenuated LPS-induced liver injury, and blunted the rises of serum TNF-alpha levels and lipid peroxidation and the induction of expressions of TNF-alpha, iNOS in the liver.	Polyphenols	22-33	tumor necrosis factor	Rattus norvegicus	102-111
16698588-9	2006	Pretreatment with tea polyphenols attenuated LPS-induced liver injury, and blunted the rises of serum TNF-alpha levels and lipid peroxidation and the induction of expressions of TNF-alpha, iNOS in the liver.	Polyphenols	22-33	tumor necrosis factor	Rattus norvegicus	178-187
16698588-9	2006	Pretreatment with tea polyphenols attenuated LPS-induced liver injury, and blunted the rises of serum TNF-alpha levels and lipid peroxidation and the induction of expressions of TNF-alpha, iNOS in the liver.	Polyphenols	22-33	nitric oxide synthase 2	Rattus norvegicus	189-193
16698588-10	2006	CONCLUSION: Tea polyphenols prevent LPS-induced liver injury, and the mechanisms may involve the reduction of serum TNF-alpha levels and lipid peroxidation and the suppression of TNF-alpha, iNOS expressions in the liver.	Polyphenols	16-27	tumor necrosis factor	Rattus norvegicus	116-125
16698588-10	2006	CONCLUSION: Tea polyphenols prevent LPS-induced liver injury, and the mechanisms may involve the reduction of serum TNF-alpha levels and lipid peroxidation and the suppression of TNF-alpha, iNOS expressions in the liver.	Polyphenols	16-27	tumor necrosis factor	Rattus norvegicus	179-188
16698588-10	2006	CONCLUSION: Tea polyphenols prevent LPS-induced liver injury, and the mechanisms may involve the reduction of serum TNF-alpha levels and lipid peroxidation and the suppression of TNF-alpha, iNOS expressions in the liver.	Polyphenols	16-27	nitric oxide synthase 2	Rattus norvegicus	190-194
16508969-0	2006	Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis.	Polyphenols	10-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-77
16506855-6	2006	Treatment of J774A.1 macrophages with PBP (10 or 50 micromol/L of total polyphenols) significantly decreased both cellular total peroxide content and Ox-LDL uptake.	Polyphenols	72-83	dedicator of cyto-kinesis 3	Mus musculus	38-41
16278067-1	2006	The aim of this study was to determine, at the mRNA and protein levels, whether tea polyphenols (TPs) affect the expression of the human telomerase reverse transcriptase (hTERT) gene in the Tca8113 cancerous cell line.	Polyphenols	84-95	telomerase reverse transcriptase	Homo sapiens	171-176
16608395-5	2006	Among the most potent and effective inhibitors of tNOX are naturally occurring polyphenols exemplified by the principal green tea catechin (-)-epigallocatechin gallate (EGCg) and the vanilloid capsaicin.	Polyphenols	79-90	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	50-54
16476731-0	2006	Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.	Polyphenols	10-21	glutamate dehydrogenase 1	Homo sapiens	63-86
16476731-4	2006	Here we report the effects of green tea polyphenols on GDH and insulin secretion.	Polyphenols	40-51	glutamate dehydrogenase 1	Homo sapiens	55-58
16539659-2	2006	Here we analyzed the effect of the main polyphenol constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), which possesses metal-chelating and radical-scavenging properties, on the regulation of the iron metabolism-related proteins APP and transferrin receptor (TfR).	Polyphenols	40-50	transferrin receptor	Homo sapiens	249-269
16539659-2	2006	Here we analyzed the effect of the main polyphenol constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), which possesses metal-chelating and radical-scavenging properties, on the regulation of the iron metabolism-related proteins APP and transferrin receptor (TfR).	Polyphenols	40-50	transferrin receptor	Homo sapiens	271-274
16381670-7	2006	Cotreatment of the oral tissue with dietary polyphenols, including resveratrol and quercetin, and BaP, resulted in significant inhibition of the BaP-DNA binding.	Polyphenols	44-55	prohibitin 2	Homo sapiens	145-148
16354769-0	2006	Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols.	Polyphenols	142-153	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
16354769-0	2006	Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols.	Polyphenols	142-153	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	26-31
16354769-11	2006	Results suggest that signaling through p38 mitogen-activated protein kinase, NF-kappaB, and Nrf2 as well as other unidentified molecules is involved in HO-1 induction by hemin and both polyphenols, but cell-specific factors also play a role, particularly with respect to EGCG.	Polyphenols	185-196	mitogen-activated protein kinase 14	Homo sapiens	39-42
16354769-0	2006	Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols.	Polyphenols	142-153	nuclear factor kappa B subunit 1	Homo sapiens	37-58
16354769-11	2006	Results suggest that signaling through p38 mitogen-activated protein kinase, NF-kappaB, and Nrf2 as well as other unidentified molecules is involved in HO-1 induction by hemin and both polyphenols, but cell-specific factors also play a role, particularly with respect to EGCG.	Polyphenols	185-196	nuclear factor kappa B subunit 1	Homo sapiens	77-86
16354769-11	2006	Results suggest that signaling through p38 mitogen-activated protein kinase, NF-kappaB, and Nrf2 as well as other unidentified molecules is involved in HO-1 induction by hemin and both polyphenols, but cell-specific factors also play a role, particularly with respect to EGCG.	Polyphenols	185-196	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
17225566-1	2006	Resveratrol (trans-3,4",5-trihydroxystilbene, CAS 501-36-0), a natural antioxidant and polyphenol found in grapes and wine, has been found to pharmacologically precondition the heart in nitric oxide (NO)-dependent manner.	Polyphenols	87-97	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	46-49
16611409-3	2006	(-)-gossypol, the negative enantiomer of a cottonseed polyphenol, binds to Bcl-x(L) and was recently been shown to inhibit HNSCC proliferation in vitro.	Polyphenols	54-64	BCL2 like 1	Homo sapiens	75-83
16263304-1	2006	In the present investigation, an attempt has been made to study the interaction of chosen polyphenols (tannic, ellagic and gallic acids) with calf thymus DNA and bovine serum albumin (BSA) employing spectrofluorimetric technique.	Polyphenols	90-101	albumin	Bos taurus	169-182
16458188-0	2006	Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis.	Polyphenols	132-143	vascular endothelial growth factor A	Homo sapiens	43-77
16404707-4	2006	Our findings suggest that a bioactive polyphenol from green tea, (-)-epigallocatechin-3-gallate (EGCG), acts to increase involucrin gene expression, suggesting that EGCG treatment enhances normal human keratinocyte differentiation.	Polyphenols	38-48	involucrin	Homo sapiens	121-131
16404708-4	2006	The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways.	Polyphenols	109-120	fatty acid synthase	Homo sapiens	65-84
16404708-4	2006	The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways.	Polyphenols	109-120	epidermal growth factor receptor	Homo sapiens	171-175
16404708-4	2006	The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways.	Polyphenols	109-120	AKT serine/threonine kinase 1	Homo sapiens	181-184
16394499-0	2006	Inhibitory effects of polyphenols on p-glycoprotein-mediated transport.	Polyphenols	22-33	ATP binding cassette subfamily B member 1	Homo sapiens	37-51
17473375-2	2006	In this study, we compared the efficacy of some polyphenols on the activation level of a cytoprotective heme oxygenase-1 (HO-1) gene in RAW264.7 mouse macrophage cells using quantitative real-time RT-PCR.	Polyphenols	48-59	heme oxygenase 1	Mus musculus	104-120
17473375-2	2006	In this study, we compared the efficacy of some polyphenols on the activation level of a cytoprotective heme oxygenase-1 (HO-1) gene in RAW264.7 mouse macrophage cells using quantitative real-time RT-PCR.	Polyphenols	48-59	heme oxygenase 1	Mus musculus	122-126
16394499-2	2006	It has been revealed that flavonoids and other polyphenols inhibit P-gp activity.	Polyphenols	47-58	ATP binding cassette subfamily B member 1	Homo sapiens	67-71
16394499-3	2006	Due to their inhibitory activities of polyphenols on P-gp function and their physiological safety, they are possible candidates for modulators of MDR.	Polyphenols	38-49	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
16394499-5	2006	Determining the structure-activity relationships is also meaningful because the intake of dietary polyphenols may also alter drug pharmacokinetics and pharmacodynamics via inhibition of P-gp-mediated drug efflux in tissues such as the intestinal epithelium, blood-brain barrier, hepatocytes and renal tubular cells.	Polyphenols	98-109	ATP binding cassette subfamily B member 1	Homo sapiens	186-190
16611078-0	2006	Inhibition of fatty acid synthase by polyphenols.	Polyphenols	37-48	fatty acid synthase	Homo sapiens	14-33
16611078-15	2006	From these results, a common model for polyphenol inhibitor of FAS is conceived.	Polyphenols	39-49	fatty acid synthase	Homo sapiens	63-66
16611078-3	2006	It is found that tea polyphenols inhibit FAS in both reversible and irreversible manners.	Polyphenols	21-32	fatty acid synthase	Homo sapiens	41-44
16352457-5	2006	The reverse-transcriptase polymerase chain reaction and reporter assay technology, employed in this study, revealed that the major component of green tea polyphenols, epigallocatechin-3-gallate had the inherent capacity to down-regulate TACO gene transcription within human macrophages through its ability to inhibit Sp1 transcription factor.	Polyphenols	154-165	coronin 1A	Homo sapiens	237-241
17105432-4	2006	Recently, various compounds such as curcumin, nicotine and wine-related polyphenols have been reported to inhibit the formation, extension of fAbeta, as well as destabilize preformed fAbeta at pH 7.5 at 37 degrees C in vitro.	Polyphenols	72-83	fumarylacetoacetate hydrolase	Mus musculus	142-148
17105432-4	2006	Recently, various compounds such as curcumin, nicotine and wine-related polyphenols have been reported to inhibit the formation, extension of fAbeta, as well as destabilize preformed fAbeta at pH 7.5 at 37 degrees C in vitro.	Polyphenols	72-83	fumarylacetoacetate hydrolase	Mus musculus	183-189
16083304-0	2006	Red wine polyphenols prevent endothelial damage induced by CCl4 administration.	Polyphenols	9-20	C-C motif chemokine ligand 4	Homo sapiens	59-63
16329824-8	2005	The Western-blotting assay showed that hTERT protein was also decreased by tea polyphenols compared to control group.	Polyphenols	79-90	telomerase reverse transcriptase	Homo sapiens	39-44
16428296-0	2005	Structure-activity relationship of polyphenols that inhibit fatty acid synthase.	Polyphenols	35-46	fatty acid synthase	Homo sapiens	60-79
16428296-2	2005	Here, using nordihydroguaiaretic acid (NDGA), with two phenyl rings connected by a four-carbon chain, as a representative, the structural basis for the inhibition of animal fatty acid synthase (FAS) by polyphenols was investigated.	Polyphenols	202-213	fatty acid synthase	Homo sapiens	173-192
16428296-2	2005	Here, using nordihydroguaiaretic acid (NDGA), with two phenyl rings connected by a four-carbon chain, as a representative, the structural basis for the inhibition of animal fatty acid synthase (FAS) by polyphenols was investigated.	Polyphenols	202-213	fatty acid synthase	Homo sapiens	194-197
16428296-8	2005	A structure-activity relationship study indicated that a biphenyl core exists in all FAS polyphenol inhibitors.	Polyphenols	89-99	fatty acid synthase	Homo sapiens	85-88
16428296-9	2005	Thus, we propose a common model possibly shared by all FAS polyphenol inhibitors.	Polyphenols	59-69	fatty acid synthase	Homo sapiens	55-58
16084102-1	2005	A series of compounds combining the beta-lactam and polyphenol scaffold have been prepared and evaluated for inhibition of human leukocyte elastase and matrix metallo-proteases MMP-2 and MMP-9.	Polyphenols	52-62	matrix metallopeptidase 2	Homo sapiens	177-182
16084102-1	2005	A series of compounds combining the beta-lactam and polyphenol scaffold have been prepared and evaluated for inhibition of human leukocyte elastase and matrix metallo-proteases MMP-2 and MMP-9.	Polyphenols	52-62	matrix metallopeptidase 9	Homo sapiens	187-192
15956028-0	2005	Provinol prevents CsA-induced nephrotoxicity by reducing reactive oxygen species, iNOS, and NF-kB expression.	Polyphenols	0-8	nitric oxide synthase 2	Rattus norvegicus	82-86
15956028-0	2005	Provinol prevents CsA-induced nephrotoxicity by reducing reactive oxygen species, iNOS, and NF-kB expression.	Polyphenols	0-8	nuclear factor kappa B subunit 1	Rattus norvegicus	92-97
16329824-9	2005	CONCLUSIONS: Tea polyphenols could inhibit the proliferation of Tca8113 cells and expression of the hTERT mRNA and protein in Tca8113 cell lines.	Polyphenols	17-28	telomerase reverse transcriptase	Homo sapiens	100-105
16140266-1	2005	(-)-Epigallocatechin-3-O-gallate (EGCG), a major green tea polyphenol, has previously exhibited a suppressive effect on the expression of the high-affinity IgE receptor (FcepsilonRI).	Polyphenols	59-69	Fc epsilon receptor Ia	Homo sapiens	170-181
16156793-6	2005	Furthermore, most of the polyphenols showed direct inhibition of MRP1-mediated [3H]dinitrophenyl S-glutathione and MRP4-mediated [3H]cGMP transport in inside-out vesicles prepared from human erythrocytes.	Polyphenols	25-36	ATP binding cassette subfamily C member 1	Homo sapiens	65-69
15955639-5	2005	As these PPs have been reported to be metabolized in Caco-2 cells into substrates of MRP-2, we hypothesize that PPs and/or metabolites could impair the OTA efflux, previously proposed to be mediated by the MRP-2, through competitive inhibition for the pump.	Polyphenols	9-12	ATP binding cassette subfamily C member 2	Homo sapiens	85-90
15955639-5	2005	As these PPs have been reported to be metabolized in Caco-2 cells into substrates of MRP-2, we hypothesize that PPs and/or metabolites could impair the OTA efflux, previously proposed to be mediated by the MRP-2, through competitive inhibition for the pump.	Polyphenols	9-12	ATP binding cassette subfamily C member 2	Homo sapiens	206-211
15955639-5	2005	As these PPs have been reported to be metabolized in Caco-2 cells into substrates of MRP-2, we hypothesize that PPs and/or metabolites could impair the OTA efflux, previously proposed to be mediated by the MRP-2, through competitive inhibition for the pump.	Polyphenols	112-115	ATP binding cassette subfamily C member 2	Homo sapiens	85-90
15955639-5	2005	As these PPs have been reported to be metabolized in Caco-2 cells into substrates of MRP-2, we hypothesize that PPs and/or metabolites could impair the OTA efflux, previously proposed to be mediated by the MRP-2, through competitive inhibition for the pump.	Polyphenols	112-115	ATP binding cassette subfamily C member 2	Homo sapiens	206-211
15905203-0	2005	Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.	Polyphenols	132-143	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	26-32
15905203-7	2005	In an extension to other polyphenols, the structural analog 3",4"-DMF, in contrast to DMF, inhibited the expression of CYP1B1 both at the mRNA and protein levels.	Polyphenols	25-36	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	119-125
16392704-1	2005	To study the effects of the intake of green tea and polyphenols, which are a component of green tea, on insulin resistance and systemic inflammation, a randomized controlled trial was conducted on 66 patients aged 32-73 y (53 males and 13 females) with borderline diabetes or diabetes.	Polyphenols	52-63	insulin	Homo sapiens	104-111
16392704-7	2005	Within the intervention group, changes in insulin level tended to be associated with changes in polyphenol intake.	Polyphenols	96-106	insulin	Homo sapiens	42-49
16392704-10	2005	The positive correlation between the level of polyphenol intake and insulin level warrants further studies on the effect of green tea on insulin resistance.	Polyphenols	46-56	insulin	Homo sapiens	68-75
16156793-3	2005	This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5.	Polyphenols	55-66	ATP binding cassette subfamily C member 1	Homo sapiens	190-194
15908056-0	2005	Effects of polyphenols on human Th1 and Th2 cytokine production.	Polyphenols	11-22	negative elongation factor complex member C/D	Homo sapiens	32-35
16270650-0	2005	The polyphenols quercetin and catechin synergize in inhibiting platelet CD40L expression.	Polyphenols	4-15	CD40 ligand	Homo sapiens	72-77
16111645-4	2005	Inhibitors of cytochromes P-450, alpha-naphthoflavone and izoniazide, decreased the cytotoxicity of several polyphenols, whereas 3,5-dinitrocatechol, an inhibitor of catechol-o-methyltransferase (COMT), increased it.	Polyphenols	108-119	catechol-O-methyltransferase	Homo sapiens	196-200
16111645-8	2005	Depending on the examined system, this parallelism may be distorted due to the cytochrome P-450 and COMT-catalyzed transformation of polyphenols.	Polyphenols	133-144	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-95
16111645-8	2005	Depending on the examined system, this parallelism may be distorted due to the cytochrome P-450 and COMT-catalyzed transformation of polyphenols.	Polyphenols	133-144	catechol-O-methyltransferase	Homo sapiens	100-104
16023083-8	2005	Consequently, the expression of all NF-kappaB-regulated gene products, were downregulated by the polyphenol leading to the suppression of proliferation, cell cycle arrest at the G1/S phase of the cell cycle and induction of apoptosis as indicated by caspase activation, PARP cleavage, and annexin V staining.	Polyphenols	97-107	collagen type XI alpha 2 chain	Homo sapiens	270-274
16023083-8	2005	Consequently, the expression of all NF-kappaB-regulated gene products, were downregulated by the polyphenol leading to the suppression of proliferation, cell cycle arrest at the G1/S phase of the cell cycle and induction of apoptosis as indicated by caspase activation, PARP cleavage, and annexin V staining.	Polyphenols	97-107	annexin A5	Homo sapiens	289-298
15860507-5	2005	In addition, the polyphenol triggered the phosphorylation of c-JUN (Ser63 and Ser73) and induced c-JUN/c-FOS, thereby increasing the DNA binding activity of activator protein-1 (AP-1), as shown by an AP-1 luciferase reporter assay.	Polyphenols	17-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-66
15860507-5	2005	In addition, the polyphenol triggered the phosphorylation of c-JUN (Ser63 and Ser73) and induced c-JUN/c-FOS, thereby increasing the DNA binding activity of activator protein-1 (AP-1), as shown by an AP-1 luciferase reporter assay.	Polyphenols	17-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
15860507-5	2005	In addition, the polyphenol triggered the phosphorylation of c-JUN (Ser63 and Ser73) and induced c-JUN/c-FOS, thereby increasing the DNA binding activity of activator protein-1 (AP-1), as shown by an AP-1 luciferase reporter assay.	Polyphenols	17-27	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
15860507-5	2005	In addition, the polyphenol triggered the phosphorylation of c-JUN (Ser63 and Ser73) and induced c-JUN/c-FOS, thereby increasing the DNA binding activity of activator protein-1 (AP-1), as shown by an AP-1 luciferase reporter assay.	Polyphenols	17-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-176
15860507-5	2005	In addition, the polyphenol triggered the phosphorylation of c-JUN (Ser63 and Ser73) and induced c-JUN/c-FOS, thereby increasing the DNA binding activity of activator protein-1 (AP-1), as shown by an AP-1 luciferase reporter assay.	Polyphenols	17-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-182
15860507-5	2005	In addition, the polyphenol triggered the phosphorylation of c-JUN (Ser63 and Ser73) and induced c-JUN/c-FOS, thereby increasing the DNA binding activity of activator protein-1 (AP-1), as shown by an AP-1 luciferase reporter assay.	Polyphenols	17-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	200-204
15860507-9	2005	Further, (-)-epicatechin-3-gallate (25 and 100 microM) and green tea polyphenols (33 and 132 microg/ml) induced pro-MMP-7 expression, whereas (-)-epicatechin and (-)-epigallocatechin (100 microM each) did not.	Polyphenols	69-80	matrix metallopeptidase 7	Homo sapiens	116-121
16156793-3	2005	This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5.	Polyphenols	55-66	ATP binding cassette subfamily C member 4	Homo sapiens	196-200
16156793-3	2005	This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5.	Polyphenols	55-66	ATP binding cassette subfamily C member 5	Homo sapiens	205-209
16156793-4	2005	At nontoxic concentrations, several of the polyphenols were able to modulate MRP1-, MRP4- and MRP5-mediated drug resistance, though to varying extents.	Polyphenols	43-54	ATP binding cassette subfamily C member 1	Homo sapiens	77-81
16156793-4	2005	At nontoxic concentrations, several of the polyphenols were able to modulate MRP1-, MRP4- and MRP5-mediated drug resistance, though to varying extents.	Polyphenols	43-54	ATP binding cassette subfamily C member 4	Homo sapiens	84-88
16156793-4	2005	At nontoxic concentrations, several of the polyphenols were able to modulate MRP1-, MRP4- and MRP5-mediated drug resistance, though to varying extents.	Polyphenols	43-54	ATP binding cassette subfamily C member 5	Homo sapiens	94-98
16156793-6	2005	Furthermore, most of the polyphenols showed direct inhibition of MRP1-mediated [3H]dinitrophenyl S-glutathione and MRP4-mediated [3H]cGMP transport in inside-out vesicles prepared from human erythrocytes.	Polyphenols	25-36	ATP binding cassette subfamily C member 4	Homo sapiens	115-119
15885676-5	2005	The thrombin-induced activation of secreted MMP-2 was abolished by GTE and the green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG).	Polyphenols	89-100	coagulation factor II, thrombin	Homo sapiens	4-12
16156793-5	2005	The polyphenols also reversed resistance to NSC251820, a compound that appears to be a good substrate for MRP4, as predicted by data-mining studies.	Polyphenols	4-15	ATP binding cassette subfamily C member 4	Homo sapiens	106-110
15802301-4	2005	Experimental data showed that green tea polyphenols could inhibit angiotensin II-induced reactive oxygen species production.	Polyphenols	40-51	angiotensinogen	Homo sapiens	66-80
15802301-5	2005	We reasoned that if this is one of the mechanisms by which green tea polyphenols protect against human breast cancer, then their effect should be more prominent among women possessing high-activity ACE genotype than women with low-activity ACE genotype.	Polyphenols	69-80	angiotensin I converting enzyme	Homo sapiens	198-201
15885676-5	2005	The thrombin-induced activation of secreted MMP-2 was abolished by GTE and the green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG).	Polyphenols	89-100	matrix metallopeptidase 2	Homo sapiens	44-49
15990587-10	2005	Nutritional antioxidants, such as polyphenols, increase PON1 mRNA expression and activity, by an aryl hydrocarbon receptor-dependent mechanism.	Polyphenols	34-45	paraoxonase 1	Homo sapiens	56-60
15665048-7	2005	Results showed that treatment of TEVM with Provinols significantly potentiated the contractile responses induced by histamine and bradykinin.	Polyphenols	43-52	kininogen 1	Homo sapiens	130-140
16329491-6	2005	The result shows that NIR is feasible and superior in analyzing the content of caffeine in tea polyphenol.	Polyphenols	95-105	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	22-25
15759309-3	2005	The protein tyrosine kinase activity of an EGFR preparation was effectively inhibited by the polyphenol-rich apple juice extract.	Polyphenols	93-103	epidermal growth factor receptor	Homo sapiens	43-47
15930455-7	2005	In the human monocyte cell line, THP-1, OVW reduced LPS-induced TNF-alpha production by 50% at a concentration of 0.5 g/L (equivalent to approximately 0.03 g/L simple and polyphenols).	Polyphenols	171-182	GLI family zinc finger 2	Homo sapiens	33-38
15895994-4	2005	In this work, we have determined a complete kinetic scheme to explain the slow-binding inhibition and the pH effects observed during the inhibition of bovine liver DHFR by these tea polyphenols.	Polyphenols	182-193	dihydrofolate reductase	Bos taurus	164-168
15823585-0	2005	Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity.	Polyphenols	70-81	matrix metallopeptidase 2	Homo sapiens	105-134
15749705-2	2005	Resveratrol, a polyphenol found in wines and thought to harbor major health benefits, was reported to be an activator of Sir2 enzymes in vivo and in vitro.	Polyphenols	15-25	sirtuin 2	Homo sapiens	121-125
15475053-3	2005	The aim of our studies was to develop novel tissue-processing techniques targeted specifically at elastin stabilization by using tannic acid (TA), a plant polyphenol capable of protecting elastin from digestion by specific enzymes.	Polyphenols	155-165	elastin	Rattus norvegicus	98-105
15475053-3	2005	The aim of our studies was to develop novel tissue-processing techniques targeted specifically at elastin stabilization by using tannic acid (TA), a plant polyphenol capable of protecting elastin from digestion by specific enzymes.	Polyphenols	155-165	elastin	Rattus norvegicus	188-195
15661805-2	2005	In this study, we report that ellagic acid (EA), a natural polyphenol found in fruits and nuts, inhibits VEGF-induced phosphorylation of VEGFR-2 in endothelial cell (EC) as well as PDGF-induced phosphorylation of PDGFR in smooth muscle cells, leading to the inhibition of downstream signaling triggered by these receptors.	Polyphenols	59-69	vascular endothelial growth factor A	Homo sapiens	105-109
15913331-0	2005	Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro.	Polyphenols	33-44	pancreatic lipase	Homo sapiens	48-65
15913331-1	2005	Fifty-four polyphenols isolated from tea leaves were evaluated for their inhibitory activities against pancreatic lipase, the key enzyme of lipid absorption in the gut.	Polyphenols	11-22	pancreatic lipase	Homo sapiens	103-120
15781239-2	2005	We reported previously that nordihydroguaiaretic acid (NDGA) and wine-related polyphenol, myricetin (Myr), inhibit fAbeta formation from Abeta and destabilize preformed fAbeta in vitro.	Polyphenols	78-88	FA complementation group B	Homo sapiens	115-121
15781239-2	2005	We reported previously that nordihydroguaiaretic acid (NDGA) and wine-related polyphenol, myricetin (Myr), inhibit fAbeta formation from Abeta and destabilize preformed fAbeta in vitro.	Polyphenols	78-88	FA complementation group B	Homo sapiens	169-175
15661808-3	2005	Our previous study has shown that quercetin, one of the main polyphenols, can effectively inhibit the expression and function of the AR.	Polyphenols	61-72	androgen receptor	Homo sapiens	133-135
15661813-1	2005	The objective of this study was to examine the ability of dietary polyphenols to inhibit cytochrome P450 (CYP) 1A1 expression and activity and benzo[a]pyrene (BaP) DNA binding, with the main emphasis on prevention of chemical-induced hepatic carcinogenesis.	Polyphenols	66-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	89-114
15661813-5	2005	Second, we screened 25 polyphenols with highly varying chemical structures for maximum ability to inhibit CYP1A1 activity in the Hep G2 cells.	Polyphenols	23-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	106-112
15795424-0	2005	Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity.	Polyphenols	13-24	apolipoprotein E	Mus musculus	66-82
15759309-6	2005	However, as to be expected from the final concentration of these potential EGFR inhibitors in the original polyphenol-rich extract, a synthetic mixture of the apple juice constituents identified and available so far, including both proanthocyanidins and the quercetin glycosides, showed only marginal inhibitory effects on the EGFR.	Polyphenols	107-117	epidermal growth factor receptor	Homo sapiens	75-79
15759309-7	2005	These results permit the assumption that yet unknown constituents contribute substantially to the potent EGFR-inhibitory properties of polyphenol-rich apple juice extract.	Polyphenols	135-145	epidermal growth factor receptor	Homo sapiens	105-109
15623569-0	2005	Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery.	Polyphenols	9-19	AKT serine/threonine kinase 1	Homo sapiens	115-118
15781612-1	2005	A naturally occurring gallated polyphenol isolated from green tea leaves, (-)-epigallocatechin gallate (EGCG), has been shown to be an inhibitor of dihydrofolate reductase (DHFR) activity in vitro at concentrations found in the serum and tissues of green tea drinkers (0.1-1.0 micromol/L).	Polyphenols	31-41	dihydrofolate reductase	Homo sapiens	148-171
15781612-1	2005	A naturally occurring gallated polyphenol isolated from green tea leaves, (-)-epigallocatechin gallate (EGCG), has been shown to be an inhibitor of dihydrofolate reductase (DHFR) activity in vitro at concentrations found in the serum and tissues of green tea drinkers (0.1-1.0 micromol/L).	Polyphenols	31-41	dihydrofolate reductase	Homo sapiens	173-177
15769121-8	2005	These results indicate that polyphenols-induced vasorelaxation may also be sustained by smooth muscle PDE inhibition by anthocyanins present in red wines and grapes.	Polyphenols	28-39	aldehyde dehydrogenase 7 family member A1	Homo sapiens	102-105
15769132-9	2005	Results from storage tests seem to relate PPO activity with color changes associated with browning and lycopene degradation, because lycopene is an antioxidant agent that reconstitutes the polyphenols oxidized by the action of PPO.	Polyphenols	189-200	polyphenol oxidase B, chloroplastic	Solanum lycopersicum	42-45
15769132-9	2005	Results from storage tests seem to relate PPO activity with color changes associated with browning and lycopene degradation, because lycopene is an antioxidant agent that reconstitutes the polyphenols oxidized by the action of PPO.	Polyphenols	189-200	polyphenol oxidase B, chloroplastic	Solanum lycopersicum	227-230
15469417-2	2005	Glucose uptake by some members of the GLUT family, mainly GLUT1, is inhibited by flavonoids, the natural polyphenols present in fruits, vegetables and wine.	Polyphenols	105-116	glutaminase	Rattus norvegicus	38-42
15469417-2	2005	Glucose uptake by some members of the GLUT family, mainly GLUT1, is inhibited by flavonoids, the natural polyphenols present in fruits, vegetables and wine.	Polyphenols	105-116	solute carrier family 2 member 1	Rattus norvegicus	58-63
15537824-0	2005	Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14.	Polyphenols	10-20	cyclin dependent kinase inhibitor 1C	Homo sapiens	113-116
15703815-10	2005	Similar reactivation of MGMT gene by dietary polyphenols, (-)-epigallocatechin-3-gallate and genistein, has also been observed.	Polyphenols	45-56	O-6-methylguanine-DNA methyltransferase	Homo sapiens	24-28
15703815-11	2005	The results suggest that the DNA hypermethylation of MGMT is an important mechanism for MGMT gene silencing in the development of ESCC, and this epigenetic event may be prevented or reversed by these polyphenols for the prevention of carcinogenesis.	Polyphenols	200-211	O-6-methylguanine-DNA methyltransferase	Homo sapiens	53-57
15703815-11	2005	The results suggest that the DNA hypermethylation of MGMT is an important mechanism for MGMT gene silencing in the development of ESCC, and this epigenetic event may be prevented or reversed by these polyphenols for the prevention of carcinogenesis.	Polyphenols	200-211	O-6-methylguanine-DNA methyltransferase	Homo sapiens	88-92
15537824-0	2005	Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14.	Polyphenols	10-20	cyclin dependent kinase inhibitor 1C	Homo sapiens	117-121
15537824-0	2005	Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14.	Polyphenols	10-20	caspase 14	Homo sapiens	126-136
15652768-1	2005	This study investigated for the first time the effects of the cis isomer of RESV (c-RESV), a polyphenol present in red wine, on an array of genes whose expression is controlled by nuclear factor kappa B (NF-kappaB) and whose transcriptional activation is critical in a number of pathologies (including some cardiovascular diseases).	Polyphenols	93-103	nuclear factor kappa B subunit 1	Homo sapiens	180-202
15800392-7	2005	Inhibitory activities of plant extracts towards cytokine activated NF-kappaB and AP-1 depend to some extent on the order of addition of IL-1 and plant extract to the cell culture, but the mechanism of action of extract components is not clear: although plant polyphenols may participate they are unlikely to be the only mediators, and MAP kinases were found generally not involved in down-regulation of transcription factors activity by plant extracts.	Polyphenols	259-270	interleukin 1 alpha	Homo sapiens	136-140
15740983-2	2005	Especially red wine is a rich source of polyphenols, and we have previously shown that French red wine upregulates eNOS, a protective enzyme in the cardiovascular system.	Polyphenols	40-51	nitric oxide synthase 3	Homo sapiens	115-119
15550455-0	2005	The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols.	Polyphenols	163-174	signal transducer and activator of transcription 1	Mus musculus	65-70
15652768-1	2005	This study investigated for the first time the effects of the cis isomer of RESV (c-RESV), a polyphenol present in red wine, on an array of genes whose expression is controlled by nuclear factor kappa B (NF-kappaB) and whose transcriptional activation is critical in a number of pathologies (including some cardiovascular diseases).	Polyphenols	93-103	nuclear factor kappa B subunit 1	Homo sapiens	204-213
15713891-9	2005	Our results show that the natural polyphenol inhibitor of Bcl-2/Bcl-xL, (-)-gossypol, can radiosensitize prostate cancer in vitro and in vivo without augmenting toxicity.	Polyphenols	34-44	BCL2 apoptosis regulator	Homo sapiens	58-63
15713891-9	2005	Our results show that the natural polyphenol inhibitor of Bcl-2/Bcl-xL, (-)-gossypol, can radiosensitize prostate cancer in vitro and in vivo without augmenting toxicity.	Polyphenols	34-44	BCL2 like 1	Homo sapiens	64-70
15626591-5	2005	This review highlights the importance of C/EBP beta and NF-kappa B in COX-2 transcriptional activation by proinflammatory mediators and as targets of inhibition by endogenous molecules such as melatonin and natural products including salicylate and polyphenols.	Polyphenols	249-260	CCAAT enhancer binding protein beta	Homo sapiens	41-51
15626591-5	2005	This review highlights the importance of C/EBP beta and NF-kappa B in COX-2 transcriptional activation by proinflammatory mediators and as targets of inhibition by endogenous molecules such as melatonin and natural products including salicylate and polyphenols.	Polyphenols	249-260	prostaglandin-endoperoxide synthase 2	Homo sapiens	70-75
15694706-4	2005	Indeed, there is recent evidence that coffee increases production of the incretin hormone glucagon-like peptide-1 (GLP-1), possibly owing to an inhibitory effect of chlorogenic acid (CGA -- the chief polyphenol in coffee) on glucose absorption.	Polyphenols	200-210	glucagon like peptide 1 receptor	Homo sapiens	115-120
15656669-4	2005	We have attempted to enrich the cellular TRX content in Saccharomyces cerevisiae, and found that green tea extract (Sunphenon), which is rich in catechins (polyphenols), activates the Yap1 transcription factor, leading to the induction of TRX2, a target of Yap1.	Polyphenols	156-167	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	184-188
15656669-4	2005	We have attempted to enrich the cellular TRX content in Saccharomyces cerevisiae, and found that green tea extract (Sunphenon), which is rich in catechins (polyphenols), activates the Yap1 transcription factor, leading to the induction of TRX2, a target of Yap1.	Polyphenols	156-167	thioredoxin TRX2	Saccharomyces cerevisiae S288C	239-243
15656669-4	2005	We have attempted to enrich the cellular TRX content in Saccharomyces cerevisiae, and found that green tea extract (Sunphenon), which is rich in catechins (polyphenols), activates the Yap1 transcription factor, leading to the induction of TRX2, a target of Yap1.	Polyphenols	156-167	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	257-261
16173528-5	2005	The tyrosinase inhibition effect, which is related to the skin-whitening effect, showed a 45.2% and 42.9% in the irradiated and the non-irradiated polyphenols, respectively, at a 100 ppm level.	Polyphenols	147-158	tyrosinase	Homo sapiens	4-14
15375010-3	2005	Administration of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) in the drinking water significantly decreased both tumor number and total tumor burden compared with untreated ODC/Ras mice without decreasing the elevated polyamine levels present in the ODC/Ras mice.	Polyphenols	32-42	ornithine decarboxylase, structural 1	Mus musculus	192-195
15375010-3	2005	Administration of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) in the drinking water significantly decreased both tumor number and total tumor burden compared with untreated ODC/Ras mice without decreasing the elevated polyamine levels present in the ODC/Ras mice.	Polyphenols	32-42	ornithine decarboxylase, structural 1	Mus musculus	269-272
15694706-4	2005	Indeed, there is recent evidence that coffee increases production of the incretin hormone glucagon-like peptide-1 (GLP-1), possibly owing to an inhibitory effect of chlorogenic acid (CGA -- the chief polyphenol in coffee) on glucose absorption.	Polyphenols	200-210	chromogranin A	Homo sapiens	183-186
15662752-18	2004	Several nutritional polyphenols (the secondary metabolites of plants) are COX2 and/or LOX inhibitors and iNOS activators.	Polyphenols	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
16399395-8	2005	Other coffee components such as polyphenols and K/C-free coffee are also capable of increasing GST and partially of inhibiting NAT, although to a somewhat lesser extent.	Polyphenols	32-43	glutathione S-transferase kappa 1	Homo sapiens	95-98
16399395-8	2005	Other coffee components such as polyphenols and K/C-free coffee are also capable of increasing GST and partially of inhibiting NAT, although to a somewhat lesser extent.	Polyphenols	32-43	bromodomain containing 2	Homo sapiens	127-130
15862030-5	2005	RESULTS: Tea polyphenols and tea pigments induced the appearance of DNA-LADDER; Western blot analysis demonstrated that Bcl-2 expression was significantly inhibited and the expression of Bax was significantly induced by tea polyphenols and tea pigments.	Polyphenols	13-24	BCL2 apoptosis regulator	Homo sapiens	120-125
15862030-5	2005	RESULTS: Tea polyphenols and tea pigments induced the appearance of DNA-LADDER; Western blot analysis demonstrated that Bcl-2 expression was significantly inhibited and the expression of Bax was significantly induced by tea polyphenols and tea pigments.	Polyphenols	13-24	BCL2 associated X, apoptosis regulator	Homo sapiens	187-190
15862030-5	2005	RESULTS: Tea polyphenols and tea pigments induced the appearance of DNA-LADDER; Western blot analysis demonstrated that Bcl-2 expression was significantly inhibited and the expression of Bax was significantly induced by tea polyphenols and tea pigments.	Polyphenols	224-235	BCL2 apoptosis regulator	Homo sapiens	120-125
15862030-5	2005	RESULTS: Tea polyphenols and tea pigments induced the appearance of DNA-LADDER; Western blot analysis demonstrated that Bcl-2 expression was significantly inhibited and the expression of Bax was significantly induced by tea polyphenols and tea pigments.	Polyphenols	224-235	BCL2 associated X, apoptosis regulator	Homo sapiens	187-190
16091006-0	2005	Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells.	Polyphenols	10-21	plasminogen activator, urokinase	Homo sapiens	44-75
16091006-0	2005	Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells.	Polyphenols	10-21	plasminogen activator, urokinase	Homo sapiens	77-80
15541362-0	2004	Green tea polyphenols as inhibitors of ribonuclease A.	Polyphenols	10-21	ribonuclease pancreatic	Bos taurus	39-53
15662752-18	2004	Several nutritional polyphenols (the secondary metabolites of plants) are COX2 and/or LOX inhibitors and iNOS activators.	Polyphenols	20-31	lysyl oxidase	Homo sapiens	86-89
15574782-0	2004	Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer.	Polyphenols	30-41	insulin-like growth factor 1	Mus musculus	51-79
15659813-4	2004	In this study, we have investigated the possible protective effects of formulated polyphenol oligomers (Oligonol) derived from grape seed extracts on Abeta-induced oxidative cell death.	Polyphenols	82-92	amyloid beta precursor protein	Rattus norvegicus	150-155
15574782-1	2004	We earlier demonstrated that oral infusion of green tea polyphenols inhibits development and progression of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) model.	Polyphenols	56-67	dermatopontin	Mus musculus	176-181
15574782-3	2004	In this study, we examined the role of IGF/IGFBP-3 signaling and its downstream and other associated events during chemoprevention of prostate cancer by green tea polyphenols in TRAMP mice.	Polyphenols	163-174	dermatopontin	Mus musculus	178-183
15574782-5	2004	Continuous green tea polyphenol infusion for 24 weeks to these mice resulted in substantial reduction in the levels of IGF-I and significant increase in the levels of IGFBP-3 in the dorso-lateral prostate.	Polyphenols	21-31	insulin-like growth factor 1	Mus musculus	119-124
15574782-5	2004	Continuous green tea polyphenol infusion for 24 weeks to these mice resulted in substantial reduction in the levels of IGF-I and significant increase in the levels of IGFBP-3 in the dorso-lateral prostate.	Polyphenols	21-31	insulin-like growth factor binding protein 3	Mus musculus	167-174
15574782-7	2004	Furthermore, green tea polyphenol infusion resulted in marked inhibition of markers of angiogenesis and metastasis most notably vascular endothelial growth factor, urokinase plasminogen activator, and matrix metalloproteinases 2 and 9.	Polyphenols	23-33	matrix metallopeptidase 2	Mus musculus	164-234
15574782-8	2004	Based on our data, we suggest that IGF-I/IGFBP-3 signaling pathway is a prime pathway for green tea polyphenol-mediated inhibition of prostate cancer that limits the progression of cancer through inhibition of angiogenesis and metastasis.	Polyphenols	100-110	insulin-like growth factor 1	Mus musculus	35-40
15574782-8	2004	Based on our data, we suggest that IGF-I/IGFBP-3 signaling pathway is a prime pathway for green tea polyphenol-mediated inhibition of prostate cancer that limits the progression of cancer through inhibition of angiogenesis and metastasis.	Polyphenols	100-110	insulin-like growth factor binding protein 3	Mus musculus	41-48
15571176-5	2004	Wine polyphenols have antioxidant properties and favorably influence endothelial function, in particular by stimulating nitric oxide-mediated vasodilation and inhibiting the endothelin-1 pathway.	Polyphenols	5-16	endothelin 1	Homo sapiens	174-186
15533050-4	2004	Here, we demonstrate efficient inhibition of amyloid formation of the type 2 diabetes-related human islet amyloid polypeptide (hIAPP) by a modified aromatic peptide fragment and a small aromatic polyphenol molecule.	Polyphenols	195-205	islet amyloid polypeptide	Homo sapiens	127-132
15533050-10	2004	In line with this notion, we demonstrate remarkable inhibition of hIAPP fibril formation and cytotoxicity toward pancreatic beta-cells by a small polyphenol molecule, the nontoxic phenol red compound.	Polyphenols	146-156	islet amyloid polypeptide	Homo sapiens	66-71
15231486-0	2004	Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4.	Polyphenols	10-20	interferon gamma	Homo sapiens	100-109
15490320-7	2004	In showing predominant stimulation of infected cells and the induction especially of IFN-gamma, a cytokine that plays a central role in antimicrobial macrophage and T cell regulation, these data provide the basis for an immunological concept of gallic acid and possibly other plant polyphenols for their beneficial effects in various infectious conditions.	Polyphenols	282-293	interferon gamma	Mus musculus	85-94
15369802-1	2004	Resveratrol, a polyphenol found in red wine, was recently suggested to act as an irreversible, mechanism-based inactivator of cytochrome P450 3A4 (CYP3A4).	Polyphenols	15-25	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-145
15369802-1	2004	Resveratrol, a polyphenol found in red wine, was recently suggested to act as an irreversible, mechanism-based inactivator of cytochrome P450 3A4 (CYP3A4).	Polyphenols	15-25	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	147-153
15369802-9	2004	These results support the role of lipophilicity in the interaction of polyphenols with CYP3A4.	Polyphenols	70-81	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-93
15478205-0	2004	Reversal of LPS-induced immobility in mice by green tea polyphenols: possible COX-2 mechanism.	Polyphenols	56-67	cytochrome c oxidase II, mitochondrial	Mus musculus	78-83
15327830-2	2004	Further studies showed that these two polyphenols caused an increase in expression of c-Jun as well as its phosphorylated form in a dose-dependent manner in prostatic cell lines.	Polyphenols	38-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-91
15350128-4	2004	The unique active-site pocket in QR2 could potentially bind other natural polyphenols such as flavonoids, as proven by the high affinity exhibited by quercetin toward QR2.	Polyphenols	74-85	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	33-36
15350128-4	2004	The unique active-site pocket in QR2 could potentially bind other natural polyphenols such as flavonoids, as proven by the high affinity exhibited by quercetin toward QR2.	Polyphenols	74-85	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	167-170
15447839-3	2004	The purpose of this study was to determine the effects of green tea polyphenols on the proliferation and p44/42 mitogen-activated protein kinase (MAPK) activity in rat VSMCs simulated by native LDL.	Polyphenols	68-79	mitogen activated protein kinase 3	Rattus norvegicus	105-108
15447839-7	2004	LDL significantly enhanced the p44/42 MAPK activity, an effect obviously inhibited by green tea polyphenols (at 100 microg/ml).	Polyphenols	96-107	mitogen activated protein kinase 3	Rattus norvegicus	31-34
15447839-8	2004	These results suggest that green tea polyphenols can inhibit high levels of LDL-induced proliferation of phosphorylated p44/42 MAPK expression in rat VSMCs.	Polyphenols	37-48	mitogen activated protein kinase 3	Rattus norvegicus	120-123
15341993-7	2004	The inhibitory effect of black tea polyphenols on hormone-resistant breast cancer cells suppressed the basal receptor tyrosine phosphorylation in HER2/neu-overexpressing MCF-7 cells.	Polyphenols	35-46	erb-b2 receptor tyrosine kinase 2	Homo sapiens	146-150
15341993-7	2004	The inhibitory effect of black tea polyphenols on hormone-resistant breast cancer cells suppressed the basal receptor tyrosine phosphorylation in HER2/neu-overexpressing MCF-7 cells.	Polyphenols	35-46	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-154
15133034-0	2004	Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase.	Polyphenols	57-68	hydroxysteroid 17-beta dehydrogenase 8	Homo sapiens	90-94
15203283-1	2004	We recently reported that resveratrol, a grape-derived polyphenol, in vitro induces the apoptosis of leukemic B-cells and simultaneously inhibits the production of endogenous nitric oxide (NO) through inducible NO synthase (iNOS) down-regulation.	Polyphenols	55-65	nitric oxide synthase 2	Homo sapiens	201-222
15249422-0	2004	Red wine polyphenols induce EDHF-mediated relaxations in porcine coronary arteries through the redox-sensitive activation of the PI3-kinase/Akt pathway.	Polyphenols	9-20	AKT serine/threonine kinase 1	Homo sapiens	140-143
15133034-6	2004	A panel of other plant polyphenols was screened for FabG/FabI inhibition and antibacterial activity.	Polyphenols	23-34	hydroxysteroid 17-beta dehydrogenase 8	Homo sapiens	52-56
15047179-2	2004	Here we show that plant-derived polyphenols that interact with P-glycoprotein can also modulate the activity of the recently discovered ABC transporter, breast cancer resistance protein (BCRP/ABCG2).	Polyphenols	32-43	ATP-binding protein	Lactococcus lactis	136-151
15044435-0	2004	Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function.	Polyphenols	10-20	involucrin	Homo sapiens	59-69
15044435-3	2004	We have reported previously that (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol antioxidant, stimulates expression of the keratinocyte differentiation marker, involucrin (hINV), via a Ras, MEKK1, MEK3, p38delta signaling cascade (Balasubramanian, S., Efimova, T., and Eckert, R. L. (2002) J. Biol.	Polyphenols	84-94	involucrin	Homo sapiens	174-184
15158750-0	2004	Direct inhibition of the ubiquitin-proteasome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor.	Polyphenols	89-100	sterol regulatory element binding transcription factor 2	Homo sapiens	144-187
15158750-0	2004	Direct inhibition of the ubiquitin-proteasome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor.	Polyphenols	89-100	low density lipoprotein receptor	Homo sapiens	192-204
15169886-0	2004	Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism.	Polyphenols	8-19	aryl hydrocarbon receptor	Homo sapiens	65-90
15169886-9	2004	These observations provide a molecular mechanism for the regulation of the cardioprotective enzyme PON-1 by polyphenols.	Polyphenols	108-119	paraoxonase 1	Homo sapiens	99-104
15363298-0	2004	[Reversal of multidrug resistance of MCF-7/ADR in nude mice by grape seed polyphenol].	Polyphenols	74-84	aldo-keto reductase family 1 member B	Homo sapiens	43-46
15363298-1	2004	OBJECTIVE: To study the reversing effect of Grape seed polyphenol (GSP) on multidrug resistance of MCF-7/ADR cell in vivo.	Polyphenols	55-65	aldo-keto reductase family 1 member B	Homo sapiens	105-108
15169886-0	2004	Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism.	Polyphenols	8-19	paraoxonase 1	Homo sapiens	29-42
15113942-0	2004	Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells.	Polyphenols	48-58	interleukin 1 beta	Homo sapiens	69-78
15113942-9	2004	Therefore, the green tea polyphenol EGCG is a potent inhibitor of IL-1 beta signal transduction in vitro.	Polyphenols	25-35	interleukin 1 beta	Homo sapiens	66-75
14718582-7	2004	Antioxidant polyphenols (luteolin and resveratrol) mimicked the effects of DHPs and showed structural similarity to DHPs.	Polyphenols	12-23	deoxyhypusine synthase	Homo sapiens	75-79
14718582-7	2004	Antioxidant polyphenols (luteolin and resveratrol) mimicked the effects of DHPs and showed structural similarity to DHPs.	Polyphenols	12-23	deoxyhypusine synthase	Homo sapiens	116-120
15202862-3	2004	METHODS: Tea polyphenols were co-incubated with bovine carotid artery endothelial cells (BCAECs) in vitro and intracellular NADPH oxidase subunits p22phox and p67phox, SOD-1, and catalase protein were detected using Western blot method.	Polyphenols	13-24	neutrophil cytosolic factor 2	Bos taurus	159-166
15107579-1	2004	In the present experiment, we studied the action of buckwheat polyphenol (BWP, from Fagopyrum esculentum MOENCH) in a repeated cerebral ischemia model, which induced a strong and long-lasting impairment of spatial memory in 8-arm radial maze with hippocampal CA1 cell death in rats.	Polyphenols	62-72	carbonic anhydrase 1	Rattus norvegicus	259-262
15202862-3	2004	METHODS: Tea polyphenols were co-incubated with bovine carotid artery endothelial cells (BCAECs) in vitro and intracellular NADPH oxidase subunits p22phox and p67phox, SOD-1, and catalase protein were detected using Western blot method.	Polyphenols	13-24	superoxide dismutase [Cu-Zn]	Bos taurus	168-187
15202862-4	2004	RESULTS: Tea polyphenols of 0.4 microg/mL and 4.0 microg/mL (from either green tea or black tea) down-regulated NADPH oxidase p22phox and p67phox expressions in a dose-negative manner (P &lt; 0.05), and up-regulated the expressions of catalase (P &lt; 0.05).	Polyphenols	13-24	cytochrome b-245 alpha chain	Bos taurus	126-133
15202862-4	2004	RESULTS: Tea polyphenols of 0.4 microg/mL and 4.0 microg/mL (from either green tea or black tea) down-regulated NADPH oxidase p22phox and p67phox expressions in a dose-negative manner (P &lt; 0.05), and up-regulated the expressions of catalase (P &lt; 0.05).	Polyphenols	13-24	neutrophil cytosolic factor 2	Bos taurus	138-145
15202862-4	2004	RESULTS: Tea polyphenols of 0.4 microg/mL and 4.0 microg/mL (from either green tea or black tea) down-regulated NADPH oxidase p22phox and p67phox expressions in a dose-negative manner (P &lt; 0.05), and up-regulated the expressions of catalase (P &lt; 0.05).	Polyphenols	13-24	catalase	Bos taurus	235-243
14705020-3	2004	Compounds with strong antioxidative and free radical scavenging properties, such as polyphenols, could be effective in blocking PUFA activities, and natural flavonoids possess such qualities.	Polyphenols	84-95	pumilio RNA binding family member 3	Homo sapiens	128-132
15129760-10	2004	RT-PCR and Western blot analysis of the islets indicated that Bcl-2 levels increased by 2.5-fold and BAX levels decreased by twofold in cultures supplemented with polyphenol.	Polyphenols	163-173	BCL2 apoptosis regulator	Homo sapiens	62-67
15129760-10	2004	RT-PCR and Western blot analysis of the islets indicated that Bcl-2 levels increased by 2.5-fold and BAX levels decreased by twofold in cultures supplemented with polyphenol.	Polyphenols	163-173	BCL2 associated X, apoptosis regulator	Homo sapiens	101-104
15129760-11	2004	This resulted in BAX/Bcl-2 ratios that were lower in polyphenol-supplemented cultures than with control cultures.	Polyphenols	53-63	BCL2 associated X, apoptosis regulator	Homo sapiens	17-20
15129760-11	2004	This resulted in BAX/Bcl-2 ratios that were lower in polyphenol-supplemented cultures than with control cultures.	Polyphenols	53-63	BCL2 apoptosis regulator	Homo sapiens	21-26
14569057-0	2004	Roles of catalase and hydrogen peroxide in green tea polyphenol-induced chemopreventive effects.	Polyphenols	53-63	catalase	Homo sapiens	9-17
15456641-6	2004	In the present study, we provide evidence of the ability of different natural polyphenols and of folic acid derivatives to inhibit the biotransformation of alcohol to acetaldehyde by rat breast cytosolic XOR.	Polyphenols	78-89	xanthine dehydrogenase	Rattus norvegicus	204-207
14746923-0	2004	Green tea polyphenol (-)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats.	Polyphenols	10-20	nitric oxide synthase 1	Rattus norvegicus	82-86
14704129-0	2004	Inhibitory effect of tea polyphenols on transforming growth factor-beta1 expression in rat with cyclosporine A-induced chronic nephrotoxicity.	Polyphenols	25-36	transforming growth factor, beta 1	Rattus norvegicus	40-72
14704129-1	2004	AIM: To investigate the inhibitory effect of tea polyphenols (TP) on the transforming growth factor-beta1 (TGF-beta1) expression in rat model of cyclosporine A (CsA)-induced chronic nephrotoxicity.	Polyphenols	49-60	transforming growth factor, beta 1	Rattus norvegicus	73-105
14704129-1	2004	AIM: To investigate the inhibitory effect of tea polyphenols (TP) on the transforming growth factor-beta1 (TGF-beta1) expression in rat model of cyclosporine A (CsA)-induced chronic nephrotoxicity.	Polyphenols	49-60	transforming growth factor, beta 1	Rattus norvegicus	107-116
15134489-0	2004	Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy.	Polyphenols	62-73	BCL2 apoptosis regulator	Homo sapiens	29-34
14636833-8	2003	We propose that polyphenols may affect redox-sensitive signal transduction pathway since APC function of PD 98059, MEK inhibitor-pretreated A20 were similarly abrogated.	Polyphenols	16-27	uncharacterized protein LOC107759629	Nicotiana tabacum	140-143
15342215-8	2004	Augmented respiratory burst of neutrophils in response to thrombin-activated platelets was also inhibited by the two polyphenols as was neutrophil migration toward thrombin-induced supernatants of platelets.	Polyphenols	117-128	coagulation factor II, thrombin	Homo sapiens	58-66
15342215-8	2004	Augmented respiratory burst of neutrophils in response to thrombin-activated platelets was also inhibited by the two polyphenols as was neutrophil migration toward thrombin-induced supernatants of platelets.	Polyphenols	117-128	coagulation factor II, thrombin	Homo sapiens	164-172
15342215-10	2004	Both polyphenols inhibited thrombin-induced MAPK, JNK and focal adhesion kinase activities in endothelial cells.	Polyphenols	5-16	coagulation factor II, thrombin	Homo sapiens	27-35
15342215-10	2004	Both polyphenols inhibited thrombin-induced MAPK, JNK and focal adhesion kinase activities in endothelial cells.	Polyphenols	5-16	mitogen-activated protein kinase 8	Homo sapiens	50-53
15342215-12	2004	Moreover, the polyphenols protect endothelial adenosine nucleotide metabolism when downregulated by thrombin.	Polyphenols	14-25	coagulation factor II, thrombin	Homo sapiens	100-108
14681684-0	2003	Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice.	Polyphenols	120-130	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-106
14664511-3	2003	After content analysis, it was found that CF-H is mainly composed of polyphenols including flavonoids (6.9%), procyanidins (2.2%), (+)-catechin (0.5%), and (-)-epicatechin (0.2%).	Polyphenols	69-80	complement component factor h	Mus musculus	42-46
14690873-4	2003	These studies have shown that both ethanol and non-alcoholic components of alcoholic beverages, mainly polyphenols, reduce intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin expression of vascular endothelium, as well as monocyte adhesion to this endothelium.	Polyphenols	103-114	intercellular adhesion molecule 1	Homo sapiens	123-156
14690873-4	2003	These studies have shown that both ethanol and non-alcoholic components of alcoholic beverages, mainly polyphenols, reduce intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin expression of vascular endothelium, as well as monocyte adhesion to this endothelium.	Polyphenols	103-114	intercellular adhesion molecule 1	Homo sapiens	158-164
14690873-4	2003	These studies have shown that both ethanol and non-alcoholic components of alcoholic beverages, mainly polyphenols, reduce intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin expression of vascular endothelium, as well as monocyte adhesion to this endothelium.	Polyphenols	103-114	vascular cell adhesion molecule 1	Homo sapiens	167-200
14690873-4	2003	These studies have shown that both ethanol and non-alcoholic components of alcoholic beverages, mainly polyphenols, reduce intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin expression of vascular endothelium, as well as monocyte adhesion to this endothelium.	Polyphenols	103-114	vascular cell adhesion molecule 1	Homo sapiens	202-208
14690873-4	2003	These studies have shown that both ethanol and non-alcoholic components of alcoholic beverages, mainly polyphenols, reduce intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin expression of vascular endothelium, as well as monocyte adhesion to this endothelium.	Polyphenols	103-114	selectin E	Homo sapiens	214-224
15033756-0	2003	The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols.	Polyphenols	148-159	nitric oxide synthase 2	Homo sapiens	4-25
15033756-1	2003	Downregulation of iNOS and NO is a pathway common for flavones and polyphenols, two distinct families of phytoalexins.	Polyphenols	67-78	nitric oxide synthase 2	Homo sapiens	18-22
14616033-0	2003	Is the C-terminal region of bradykinin the binding site of polyphenols?	Polyphenols	59-70	kininogen 1	Homo sapiens	28-38
14633667-0	2003	Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.	Polyphenols	4-14	DNA methyltransferase 1	Homo sapiens	55-76
14974735-6	2003	OPN was comparable to polyphenols such as (+)-catechin, rutin and gallic acid in the antioxidative activity against linoleic acid peroxidation, and was an effective DPPH radical scavenger, though the DPPH radical-scavenging activity of OPN was somewhat lower than that of the polyphenols.	Polyphenols	22-33	secreted phosphoprotein 1	Homo sapiens	0-3
14974735-6	2003	OPN was comparable to polyphenols such as (+)-catechin, rutin and gallic acid in the antioxidative activity against linoleic acid peroxidation, and was an effective DPPH radical scavenger, though the DPPH radical-scavenging activity of OPN was somewhat lower than that of the polyphenols.	Polyphenols	276-287	secreted phosphoprotein 1	Homo sapiens	0-3
14633667-3	2003	We report herein that (-)-epigallocatechin-3-gallate (EGCG), the major polyphenol from green tea, can inhibit DNMT activity and reactivate methylation-silenced genes in cancer cells.	Polyphenols	71-81	DNA methyltransferase 1	Homo sapiens	110-114
14572614-4	2003	The elevated expression of PP-activated receptors alpha (PPARalpha) in HepG2 cells induced by FF was also decreased by treatment with green tea polyphenols.	Polyphenols	144-155	peroxisome proliferator activated receptor alpha	Homo sapiens	57-66
14612239-1	2003	An oolong tea polyphenol (OTF6) has been shown to possess a strong anti-glucosyltransferase (GTF) activity and inhibit experimental dental caries in rats infected with mutans streptococci.	Polyphenols	14-24	POU class 3 homeobox 1	Rattus norvegicus	26-30
14612239-7	2003	These results indicate that OTF6, a polymeric polyphenol specific for oolong tea is able to reduce glucan synthesis by inhibiting the GBD of S. mutans GTFB.	Polyphenols	46-56	POU class 3 homeobox 1	Rattus norvegicus	28-32
14612555-5	2003	Because catechol-containing tea polyphenols are very rapidly O-methylated by human catechol-O-methyltransferase (COMT), we are interested in determining whether the association between tea intake and breast cancer differed in women according to COMT genotype.	Polyphenols	32-43	catechol-O-methyltransferase	Homo sapiens	83-111
14612555-5	2003	Because catechol-containing tea polyphenols are very rapidly O-methylated by human catechol-O-methyltransferase (COMT), we are interested in determining whether the association between tea intake and breast cancer differed in women according to COMT genotype.	Polyphenols	32-43	catechol-O-methyltransferase	Homo sapiens	113-117
14610487-0	2003	Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding.	Polyphenols	52-62	CD4 molecule	Homo sapiens	73-76
14610487-0	2003	Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding.	Polyphenols	52-62	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	97-102
12865094-1	2003	The tannins are natural polyphenols, able to precipitate water-soluble alkaloids and possess an inhibitory action on the angiotensin converting enzyme (ACE).	Polyphenols	24-35	angiotensin I converting enzyme	Rattus norvegicus	152-155
14521957-4	2003	The reported ability of (-)-epigallocatechin gallate (EGCG), a polyphenol, to down-regulate the expression of hnRNP A2/B1, a trans-activating factor that encourages the use of intron-distal 5(") splice sites, prompted an evaluation of its effect on the IKBKAP transcript in FD-derived cells.	Polyphenols	63-73	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	110-121
14521957-4	2003	The reported ability of (-)-epigallocatechin gallate (EGCG), a polyphenol, to down-regulate the expression of hnRNP A2/B1, a trans-activating factor that encourages the use of intron-distal 5(") splice sites, prompted an evaluation of its effect on the IKBKAP transcript in FD-derived cells.	Polyphenols	63-73	elongator acetyltransferase complex subunit 1	Homo sapiens	253-259
12951464-0	2003	Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.	Polyphenols	31-42	matrix metallopeptidase 14	Homo sapiens	46-86
12951464-0	2003	Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.	Polyphenols	31-42	matrix metallopeptidase 14	Homo sapiens	88-95
12911627-7	2003	Further research showed that co-incubation of green tea polyphenols and SNP caused loss of mitochondrial membrane potential, depletion of intracellular GSH and accumulation of reactive oxygen species, and exacerbated NO-induced neuronal apoptosis via a Bcl-2 sensitive pathway.	Polyphenols	56-67	BCL2 apoptosis regulator	Homo sapiens	253-258
14710821-6	2003	Following the optimization of the paste composition, PPO-based carbon paste biosensors were prepared and presented excellent analytical properties toward catechol detection with a sensitivity of 4.7 A M(-1) cm(-2) and a response time lower than 20 s. The resulting biosensors were finally applied to the determination of epicatechin and ferulic acid as flavonol and polyphenol model, respectively.	Polyphenols	366-376	protoporphyrinogen oxidase	Homo sapiens	53-56
14512804-8	2003	In addition, the mechanism of GT chemoprevention may be different from that of GT components, such as polyphenols that reduce CYP1As activity.	Polyphenols	102-113	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	126-130
12918531-0	2003	Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells.	Polyphenols	9-20	nitric oxide synthase 3	Homo sapiens	29-62
12877923-0	2003	Size exclusion chromatographic analysis of polyphenol-serum albumin complexes.	Polyphenols	43-53	albumin	Homo sapiens	54-67
12842182-4	2003	Probing intestinal microsomes with antibodies to CYP2E1 revealed the presence of a single band in the cytochrome P450 region whose intensity was lower in the polyphenol-treated animals.	Polyphenols	158-168	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	49-55
12818727-2	2003	As resveratrol and polyphenols from red wine were reported to inhibit cytochrome P450 (CYP) activities, this led us to investigate the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities.	Polyphenols	19-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-85
14705880-0	2003	Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells.	Polyphenols	6-16	cyclin A2	Homo sapiens	145-165
12818727-2	2003	As resveratrol and polyphenols from red wine were reported to inhibit cytochrome P450 (CYP) activities, this led us to investigate the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities.	Polyphenols	19-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	87-90
12811578-9	2003	These results underline the divergent pathways involved in the downregulation of VEGF and IL-8 by polyphenols in activated keratinocytes.	Polyphenols	98-109	vascular endothelial growth factor A	Homo sapiens	81-85
12811578-9	2003	These results underline the divergent pathways involved in the downregulation of VEGF and IL-8 by polyphenols in activated keratinocytes.	Polyphenols	98-109	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
12840208-0	2003	Tomato and soy polyphenols reduce insulin-like growth factor-I-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase.	Polyphenols	15-26	insulin-like growth factor 1	Rattus norvegicus	34-62
12840208-1	2003	We examined the ability of polyphenols from tomatoes and soy (genistein, quercetin, kaempferol, biochanin A, daidzein and rutin) to modulate insulin-like growth factor-I (IGF-I)-induced in vitro proliferation and apoptotic resistance in the AT6.3 rat prostate cancer cell line.	Polyphenols	27-38	insulin-like growth factor 1	Rattus norvegicus	141-169
12840208-3	2003	Polyphenols exhibited different abilities to modulate IGF-I-induced proliferation, cell cycle progression (flow cytometry) and apoptosis (Annexin V/propidium iodide and terminal deoxynucleotidyltransferase-mediated deoxyuridine 5"-triphosphate nick end labeling).	Polyphenols	0-11	insulin-like growth factor 1	Rattus norvegicus	54-59
12840208-1	2003	We examined the ability of polyphenols from tomatoes and soy (genistein, quercetin, kaempferol, biochanin A, daidzein and rutin) to modulate insulin-like growth factor-I (IGF-I)-induced in vitro proliferation and apoptotic resistance in the AT6.3 rat prostate cancer cell line.	Polyphenols	27-38	insulin-like growth factor 1	Rattus norvegicus	171-176
12840208-3	2003	Polyphenols exhibited different abilities to modulate IGF-I-induced proliferation, cell cycle progression (flow cytometry) and apoptosis (Annexin V/propidium iodide and terminal deoxynucleotidyltransferase-mediated deoxyuridine 5"-triphosphate nick end labeling).	Polyphenols	0-11	annexin A5	Rattus norvegicus	138-147
12771038-0	2003	Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin.	Polyphenols	23-34	mitogen-activated protein kinase 1	Mus musculus	167-171
12840208-11	2003	Several polyphenols suppressed phosphorylation of AKT and ERK1/2, and more potently inhibited IRS-1 tyrosyl phosphorylation after IGF-I exposure.	Polyphenols	8-19	AKT serine/threonine kinase 1	Rattus norvegicus	50-53
12840208-11	2003	Several polyphenols suppressed phosphorylation of AKT and ERK1/2, and more potently inhibited IRS-1 tyrosyl phosphorylation after IGF-I exposure.	Polyphenols	8-19	mitogen activated protein kinase 3	Rattus norvegicus	58-64
12840208-11	2003	Several polyphenols suppressed phosphorylation of AKT and ERK1/2, and more potently inhibited IRS-1 tyrosyl phosphorylation after IGF-I exposure.	Polyphenols	8-19	insulin receptor substrate 1	Rattus norvegicus	94-99
12840208-11	2003	Several polyphenols suppressed phosphorylation of AKT and ERK1/2, and more potently inhibited IRS-1 tyrosyl phosphorylation after IGF-I exposure.	Polyphenols	8-19	insulin-like growth factor 1	Rattus norvegicus	130-135
12840208-12	2003	In summary, polyphenols from soy and tomato products may counteract the ability of IGF-I to stimulate proliferation and prevent apoptosis via inhibition of multiple intracellular signaling pathways involving tyrosine kinase activity.	Polyphenols	12-23	insulin-like growth factor 1	Rattus norvegicus	83-88
12771038-10	2003	Together, for the first time a cream based formulation of green tea polyphenols was tested in this study to explore the possibility of its use for the humans, and the data obtained from this in vivo study further suggest that GTP could be useful in attenuation of solar UVB light-induced oxidative stress-mediated and MAPK-caused skin disorders in humans.	Polyphenols	68-79	mitogen-activated protein kinase 1	Mus musculus	318-322
12672508-0	2003	Conjugation of chlorambucil with GSH by GST purified from human colon adenocarcinoma cells and its inhibition by plant polyphenols.	Polyphenols	119-130	glutathione S-transferase kappa 1	Homo sapiens	40-43
12716753-3	2003	The present investigation was initiated to evaluate whether a carbohydrate-restricted, low-iron-available, polyphenol-enriched (CR-LIPE) diet may delay and improve the outcome of diabetic nephropathy to a greater extent than standard protein restriction.	Polyphenols	107-117	lipase E, hormone sensitive type	Homo sapiens	131-135
12797479-3	2003	The aim of this study was to compare the capacity of natural polyphenols (PP) from Vitis vinifera and Olea europea at protecting LDL against oxidation brought about by Cu2+, oxygen-centered radical-generating AAPH, or peroxynitrite-generating SIN-1 in vitro systems, or at impairing superoxide production in promonocyte cells (THP-1) conveniently differentiated into adherent macrophages.	Polyphenols	61-72	MAPK associated protein 1	Homo sapiens	243-248
12797479-3	2003	The aim of this study was to compare the capacity of natural polyphenols (PP) from Vitis vinifera and Olea europea at protecting LDL against oxidation brought about by Cu2+, oxygen-centered radical-generating AAPH, or peroxynitrite-generating SIN-1 in vitro systems, or at impairing superoxide production in promonocyte cells (THP-1) conveniently differentiated into adherent macrophages.	Polyphenols	61-72	GLI family zinc finger 2	Homo sapiens	327-332
12672508-7	2003	The plant polyphenols namely tannic acid, butein, quercetin, morin, 2-hydroxychalcone and 2"-hydroxychalcone at 40 microM inhibited the GST-mediated conjugation of CMB with GSH by 38 to 62%.	Polyphenols	10-21	glutathione S-transferase kappa 1	Homo sapiens	136-139
12747740-5	2003	With respect to MDA formation, an apparent IC50 of 5.12 microM was calculated for C-3-G (the polyphenol resveratrol used for comparison showed an apparent IC50 of 38.43 microM).	Polyphenols	93-103	Rap guanine nucleotide exchange factor 1	Homo sapiens	82-87
12670496-0	2003	In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1.	Polyphenols	45-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	108-114
12670496-3	2003	We compared the effects of 11 representative natural polyphenols, which normally occur in food, on different activities of CYP1A1, namely epoxidation of 7,8-dihydrodiol-benzo[a]pyrene, the terminal step in the activation leading to the ultimate carcinogenic diolepoxides, hydroxylation of benzo[a]pyrene, and EROD.	Polyphenols	53-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129
12670496-5	2003	The results demonstrate that the inhibitory effects of dietary polyphenols on CYP1A1 activity depend on both the structure of the inhibitor and the type of the reaction and substrate used in the assay.	Polyphenols	63-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	78-84
12694877-12	2003	In addition, the finding that MA enhances TGF-beta gene expression suggests that this polyphenol might also be of value in the prevention of cancer, autoimmune disorders, atherosclerosis and coronary heart disease.	Polyphenols	86-96	transforming growth factor, beta 1	Rattus norvegicus	42-50
12670191-5	2003	Moreover, in rats given green tea polyphenol the SOD and catalase activities suppressed by excessive arginine administration increased dose-dependently, implying the biological defense system was augmented as a result of free radical scavenging.	Polyphenols	34-44	catalase	Rattus norvegicus	57-65
12654468-0	2003	Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants.	Polyphenols	36-46	PCNA clamp associated factor	Rattus norvegicus	134-160
12514805-0	2003	Microfluidic peroxidase biochip for polyphenol synthesis.	Polyphenols	36-46	peroxidase	Glycine max	13-23
12820420-0	2003	Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis.	Polyphenols	10-20	caspase 3	Homo sapiens	70-79
12820420-2	2003	We previously reported that green tea polyphenol-induced apoptosis involved Apaf-1 accumulation and caspase 3 activation in the cytosol.	Polyphenols	38-48	apoptotic peptidase activating factor 1	Homo sapiens	76-82
12820420-2	2003	We previously reported that green tea polyphenol-induced apoptosis involved Apaf-1 accumulation and caspase 3 activation in the cytosol.	Polyphenols	38-48	caspase 3	Homo sapiens	100-109
12820420-5	2003	The results demonstrated that, while the mitochondrial function gradually declined to insignificant levels, caspase 3 null cells did not undergo apoptosis, which suggested that green tea polyphenol-induced apoptosis is a mitochondria-targeted, caspase 3-executed mechanism.	Polyphenols	187-197	caspase 3	Homo sapiens	108-117
12820420-5	2003	The results demonstrated that, while the mitochondrial function gradually declined to insignificant levels, caspase 3 null cells did not undergo apoptosis, which suggested that green tea polyphenol-induced apoptosis is a mitochondria-targeted, caspase 3-executed mechanism.	Polyphenols	187-197	caspase 3	Homo sapiens	244-253
12939992-3	2003	The adsorption amount of caffine is 2.65 mg.g-1 with 7.5% adsorption ratio when 100 mL of 0.71 g.L-1 caffine is adsorbed on polyamide resine, but the adsorption amount of tea polyphenol is up to 148.13 mg.g-1 with 85% adsorption ratio when 700 mL of 1.98 g.L-1 tea polyphenol is adsorbed on polyamide resine.	Polyphenols	175-185	immunoglobulin kappa variable 1-16	Homo sapiens	97-100
12875608-6	2003	The biological properties of green tea polyphenols reported in the literature include antioxidant actions, free radical scavenging, iron-chelating properties, (3)H-dopamine and (3)H-methyl-4-phenylpyridine uptake inhibition, catechol-O-methyltransferase activity reduction, protein kinase C or extracellular signal-regulated kinases signal pathway activation, and cell survival/cell cycle gene modulation.	Polyphenols	39-50	catechol-O-methyltransferase	Homo sapiens	225-253
12495785-2	2003	Our studies have demonstrated that polyphenols extracted from green tea (GT) can inhibit the uptake of 3H-dopamine (3H-DA) and 1-methyl-4-phenylpyridinium (MPP(+)) by DA transporters (DAT) and partially protect embryonic rat mesencephalic dopaminergic (DAergic) neurons from MPP(+)-induced injury.	Polyphenols	35-46	solute carrier family 6 member 3	Rattus norvegicus	167-182
12495785-2	2003	Our studies have demonstrated that polyphenols extracted from green tea (GT) can inhibit the uptake of 3H-dopamine (3H-DA) and 1-methyl-4-phenylpyridinium (MPP(+)) by DA transporters (DAT) and partially protect embryonic rat mesencephalic dopaminergic (DAergic) neurons from MPP(+)-induced injury.	Polyphenols	35-46	solute carrier family 6 member 3	Rattus norvegicus	184-187
12495785-6	2003	Incubation with 50 microM MPP(+) resulted in a significant loss of tyrosine-hydroxylase (TH)-positive cells in the primary embryonic mesencephalic cultures, while pretreatment with polyphenols (10 to 30 microg/ml) or mazindol (10 microM), a classical DAT inhibitor, significantly attenuated MPP(+)-induced loss of TH-positive cells.	Polyphenols	181-192	solute carrier family 6 member 3	Rattus norvegicus	251-254
12495785-7	2003	These results suggest that GT polyphenols have inhibitory effects on DAT, through which they block MPP(+) uptake and protect DAergic neurons against MPP(+)-induced injury.	Polyphenols	30-41	solute carrier family 6 member 3	Rattus norvegicus	69-72
12931129-0	2003	Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects.	Polyphenols	79-90	fatty acid synthase	Homo sapiens	15-34
14769533-8	2003	Recently, it has been shown that green tea polyphenols, when given to TRAMP, a transgenic mouse model that mimics progressive forms of human prostate cancer, exert remarkable preventive effects against prostate cancer development.	Polyphenols	43-54	tumor necrosis factor receptor superfamily, member 25	Mus musculus	70-75
12507586-3	2003	In this study we evaluated the role of epigallocatechin-3-gallate (EGCG), a green tea polyphenol which mimics its anti-inflammatory effects, in modulating the IL-1beta-induced activation of MAPK"s in human chondrocytes.	Polyphenols	86-96	interleukin 1 beta	Homo sapiens	159-167
12931129-5	2003	The expression of FAS was also suppressed by the tea polyphenol (-)-epigallocatechin 3-gallate (EGCG), theaflavin (TF-1), TF-2 and theaflavin 3,3"-digallate(TF-3) at both protein and mRNA levels that may lead to the inhibition of cell lipogenesis and proliferation.	Polyphenols	53-63	fatty acid synthase	Homo sapiens	18-21
12931129-8	2003	These findings suggest that tea polyphenols suppress FAS expression by downregulating EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway, and tea and tea polyphenols might induce hypolipidemic and antiproliferative effects by suppressing FAS.	Polyphenols	32-43	fatty acid synthase	Homo sapiens	53-56
12931129-8	2003	These findings suggest that tea polyphenols suppress FAS expression by downregulating EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway, and tea and tea polyphenols might induce hypolipidemic and antiproliferative effects by suppressing FAS.	Polyphenols	32-43	epidermal growth factor	Homo sapiens	86-89
12931129-8	2003	These findings suggest that tea polyphenols suppress FAS expression by downregulating EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway, and tea and tea polyphenols might induce hypolipidemic and antiproliferative effects by suppressing FAS.	Polyphenols	32-43	AKT serine/threonine kinase 1	Homo sapiens	104-107
12931129-8	2003	These findings suggest that tea polyphenols suppress FAS expression by downregulating EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway, and tea and tea polyphenols might induce hypolipidemic and antiproliferative effects by suppressing FAS.	Polyphenols	32-43	fatty acid synthase	Homo sapiens	242-245
12553041-0	2002	Induction of p57 is required for cell survival when exposed to green tea polyphenols.	Polyphenols	73-84	cyclin dependent kinase inhibitor 1C	Homo sapiens	13-16
12494303-10	2002	Plasma-free epigallocatechin gallate concentration remained at the pre-study level; however, the plasma FRAP value decreased significantly at 7 days after the withdrawal of tea polyphenol extract.	Polyphenols	177-187	mechanistic target of rapamycin kinase	Homo sapiens	104-108
12553041-2	2002	We recently reported that green tea polyphenols potently induced a cyclin-dependent kinase inhibitor, p57/(KIP2), only in normal human epithelial cells.	Polyphenols	36-47	cyclin dependent kinase inhibitor 1C	Homo sapiens	102-105
12553041-2	2002	We recently reported that green tea polyphenols potently induced a cyclin-dependent kinase inhibitor, p57/(KIP2), only in normal human epithelial cells.	Polyphenols	36-47	cyclin dependent kinase inhibitor 1C	Homo sapiens	107-111
12553041-4	2002	It was demonstrated that, in the cells that lack p57 induction, green tea polyphenols induced Apaf-1 expression along with caspase 3 activation, leading to apoptosis.	Polyphenols	74-85	cyclin dependent kinase inhibitor 1C	Homo sapiens	49-52
12553041-4	2002	It was demonstrated that, in the cells that lack p57 induction, green tea polyphenols induced Apaf-1 expression along with caspase 3 activation, leading to apoptosis.	Polyphenols	74-85	apoptotic peptidase activating factor 1	Homo sapiens	94-100
12553041-4	2002	It was demonstrated that, in the cells that lack p57 induction, green tea polyphenols induced Apaf-1 expression along with caspase 3 activation, leading to apoptosis.	Polyphenols	74-85	caspase 3	Homo sapiens	123-132
12553041-5	2002	In contrast, cells with polyphenol-inducible p57 maintained constant levels of Apaf-1 and proliferating cell nuclear antigen (PCNA), with basal caspase 3 activity.	Polyphenols	24-34	cyclin dependent kinase inhibitor 1C	Homo sapiens	45-48
12553041-5	2002	In contrast, cells with polyphenol-inducible p57 maintained constant levels of Apaf-1 and proliferating cell nuclear antigen (PCNA), with basal caspase 3 activity.	Polyphenols	24-34	apoptotic peptidase activating factor 1	Homo sapiens	79-85
12553041-5	2002	In contrast, cells with polyphenol-inducible p57 maintained constant levels of Apaf-1 and proliferating cell nuclear antigen (PCNA), with basal caspase 3 activity.	Polyphenols	24-34	proliferating cell nuclear antigen	Homo sapiens	90-124
12553041-5	2002	In contrast, cells with polyphenol-inducible p57 maintained constant levels of Apaf-1 and proliferating cell nuclear antigen (PCNA), with basal caspase 3 activity.	Polyphenols	24-34	proliferating cell nuclear antigen	Homo sapiens	126-130
12553041-5	2002	In contrast, cells with polyphenol-inducible p57 maintained constant levels of Apaf-1 and proliferating cell nuclear antigen (PCNA), with basal caspase 3 activity.	Polyphenols	24-34	caspase 3	Homo sapiens	144-153
12553041-6	2002	Retroviral-transfected, p57-expressing oral carcinoma cells showed significant resistance to green tea polyphenol-induced apoptosis.	Polyphenols	103-113	cyclin dependent kinase inhibitor 1C	Homo sapiens	24-27
12553041-7	2002	Our results suggest that p57/KIP2 is a determinant pro-survival factor for cell protection from green tea polyphenol-induced apoptosis.	Polyphenols	106-116	cyclin dependent kinase inhibitor 1C	Homo sapiens	25-28
12553041-7	2002	Our results suggest that p57/KIP2 is a determinant pro-survival factor for cell protection from green tea polyphenol-induced apoptosis.	Polyphenols	106-116	cyclin dependent kinase inhibitor 1C	Homo sapiens	29-33
12433185-12	2002	TF-3 and other tea polyphenols also inhibited strongly the activities of xanthine oxidase, cyclooxygenase, EGF-receptor tyrosine kinase and protein kinase C. These results suggest that TF-3 and other tea polyphenols may exert their cancer chemoprevention through suppressing tumor promotion and inflammation by blocking signal transduction.	Polyphenols	19-30	xanthine dehydrogenase	Mus musculus	73-89
12494882-6	2002	Additionally, tea polyphenols inhibit the activities of many tumor-associated protein kinases, including epidermal growth factor receptor, vascular endothelial growth factor receptor, platelet-derived growth factor receptor, mitogen-activated protein kinase, and IkB kinase.	Polyphenols	18-29	epidermal growth factor receptor	Homo sapiens	105-137
12470903-5	2002	Among the various agents, (-)-epigallocatechin gallate (EGCG) and green tea polyphenols inhibited TNF-alpha gene expression in the cells induced by tumor promoter, mediated through inhibition of NF-kappaB activation.	Polyphenols	76-87	tumor necrosis factor	Homo sapiens	98-107
12481898-8	2002	Polyphenol-driven apoptosis in chronic leukemic B cells was shown to correlate with an activation of caspase 3, a drop in the mitochondrial transmembrane potential, a reduction in the expression of the anti-apoptotic protein bcl-2, as well as a reduction in the expression of the inducible nitric oxide synthase (iNOS).	Polyphenols	0-10	caspase 3	Homo sapiens	101-110
12238566-0	2002	A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium.	Polyphenols	20-30	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
12238566-3	2002	Herein we determined the effects of epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, on tumor necrosis factor-alpha (TNF-alpha)-mediated expression of the IL-8 gene in A549 cells.	Polyphenols	91-101	tumor necrosis factor	Homo sapiens	106-133
12238566-3	2002	Herein we determined the effects of epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, on tumor necrosis factor-alpha (TNF-alpha)-mediated expression of the IL-8 gene in A549 cells.	Polyphenols	91-101	tumor necrosis factor	Homo sapiens	135-144
12238566-3	2002	Herein we determined the effects of epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, on tumor necrosis factor-alpha (TNF-alpha)-mediated expression of the IL-8 gene in A549 cells.	Polyphenols	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12481898-8	2002	Polyphenol-driven apoptosis in chronic leukemic B cells was shown to correlate with an activation of caspase 3, a drop in the mitochondrial transmembrane potential, a reduction in the expression of the anti-apoptotic protein bcl-2, as well as a reduction in the expression of the inducible nitric oxide synthase (iNOS).	Polyphenols	0-10	BCL2 apoptosis regulator	Homo sapiens	225-230
12481898-8	2002	Polyphenol-driven apoptosis in chronic leukemic B cells was shown to correlate with an activation of caspase 3, a drop in the mitochondrial transmembrane potential, a reduction in the expression of the anti-apoptotic protein bcl-2, as well as a reduction in the expression of the inducible nitric oxide synthase (iNOS).	Polyphenols	0-10	nitric oxide synthase 2	Homo sapiens	280-311
12481898-8	2002	Polyphenol-driven apoptosis in chronic leukemic B cells was shown to correlate with an activation of caspase 3, a drop in the mitochondrial transmembrane potential, a reduction in the expression of the anti-apoptotic protein bcl-2, as well as a reduction in the expression of the inducible nitric oxide synthase (iNOS).	Polyphenols	0-10	nitric oxide synthase 2	Homo sapiens	313-317
12572356-6	2002	The result of RT-PCR analysis demonstrated that Cdk4 was significantly inhibited by tea polyphenols and tea pigments.	Polyphenols	88-99	cyclin dependent kinase 4	Homo sapiens	48-52
12237322-0	2002	Inhibition of bcl-x(l) phosphorylation by tea polyphenols or epigallocatechin-3-gallate is associated with prostate cancer cell apoptosis.	Polyphenols	46-57	BCL2 like 1	Homo sapiens	14-19
12237322-4	2002	Treatment with tea polyphenols or the major tea component epigallocatechin-3-gallate blocked expression of the hyper-, but not hypophosphorylated Bcl-X(L) in mitochondria, accompanied by cytochrome c release, caspase activation, and apoptosis.	Polyphenols	19-30	BCL2 like 1	Homo sapiens	146-154
12237322-4	2002	Treatment with tea polyphenols or the major tea component epigallocatechin-3-gallate blocked expression of the hyper-, but not hypophosphorylated Bcl-X(L) in mitochondria, accompanied by cytochrome c release, caspase activation, and apoptosis.	Polyphenols	19-30	cytochrome c, somatic	Homo sapiens	187-199
12572356-5	2002	Western blot analysis showed tea polyphenols and tea pigments significantly inhibited the expression of cyclin D1 protein and induced higher expression of P21WAFI/CIPI protein.	Polyphenols	33-44	cyclin D1	Homo sapiens	104-113
12123743-1	2002	Flavanols--a class of plant polyphenols abundant in tea leaves and grape seeds and skins--have been found to inhibit some matrix-proteases instrumental in inflammation and cancer invasion, such as leukocyte elastase (LE) and gelatinases.	Polyphenols	28-39	elastase, neutrophil expressed	Homo sapiens	197-215
12270851-0	2002	Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells.	Polyphenols	9-20	nitric oxide synthase 3	Homo sapiens	29-62
12270851-3	2002	This study examines the influence of red wine polyphenols on the regulation of endothelial nitric oxide synthase (eNOS) expression and subsequent NO synthesis, focusing on the putative long-lasting antiatherosclerotic effects of red wine.	Polyphenols	46-57	nitric oxide synthase 3	Homo sapiens	79-112
12270851-3	2002	This study examines the influence of red wine polyphenols on the regulation of endothelial nitric oxide synthase (eNOS) expression and subsequent NO synthesis, focusing on the putative long-lasting antiatherosclerotic effects of red wine.	Polyphenols	46-57	nitric oxide synthase 3	Homo sapiens	114-118
12270851-7	2002	Furthermore, we found an increased human eNOS promotor activity (up to 2-fold) in response to red wine polyphenols (18 hours, 100 to 600 microg/mL), as demonstrated by a luciferase reporter gene assay.	Polyphenols	103-114	nitric oxide synthase 3	Homo sapiens	41-45
12270851-9	2002	Increased active eNOS levels may antagonize the development of endothelial dysfunction and atherosclerosis, a hypothesis that supports the view that red wine indeed may have long-term protective cardiovascular properties mediated by its polyphenols.	Polyphenols	237-248	nitric oxide synthase 3	Homo sapiens	17-21
12221251-4	2002	Here, we show that the total polyphenol pool isolated from a red wine (varity Lemberger, vintage 1998) at micromolar concentrations inhibited the proliferation of transformed colon epithelial cells HT 29 clone 19A induced by epidermal growth factor (EGF).	Polyphenols	29-39	epidermal growth factor	Homo sapiens	225-248
12221251-4	2002	Here, we show that the total polyphenol pool isolated from a red wine (varity Lemberger, vintage 1998) at micromolar concentrations inhibited the proliferation of transformed colon epithelial cells HT 29 clone 19A induced by epidermal growth factor (EGF).	Polyphenols	29-39	epidermal growth factor	Homo sapiens	250-253
12221251-6	2002	Stress activated c-Jun N-terminal kinases 1/2 (JNK) and p38 MAPK were significantly activated by red wine polyphenols (6 mmol/L).	Polyphenols	106-117	mitogen-activated protein kinase 8	Homo sapiens	17-51
12221251-8	2002	In contrast, activation of extracellular signal regulated kinase (ERK) 1/2 by EGF (1 nmol/L) was significantly inhibited by red wine polyphenols (6 mmol/L).	Polyphenols	133-144	mitogen-activated protein kinase 1	Homo sapiens	27-74
12221251-8	2002	In contrast, activation of extracellular signal regulated kinase (ERK) 1/2 by EGF (1 nmol/L) was significantly inhibited by red wine polyphenols (6 mmol/L).	Polyphenols	133-144	epidermal growth factor	Homo sapiens	78-81
12221251-9	2002	This signaling pattern, activation of JNK 1/2 and p38 MAPK and inhibition of ERK 1/2, is typical for antiproliferative compounds, indicating that red wine polyphenols may inhibit the proliferation of colon carcinoma cells by modulating MAPK intracellular signal transduction pathways.	Polyphenols	155-166	mitogen-activated protein kinase 8	Homo sapiens	38-45
12221251-9	2002	This signaling pattern, activation of JNK 1/2 and p38 MAPK and inhibition of ERK 1/2, is typical for antiproliferative compounds, indicating that red wine polyphenols may inhibit the proliferation of colon carcinoma cells by modulating MAPK intracellular signal transduction pathways.	Polyphenols	155-166	mitogen-activated protein kinase 3	Homo sapiens	77-84
12209512-3	2002	In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced production of NO in primary human osteoarthritis (OA) chondrocytes.	Polyphenols	95-105	interleukin 1 beta	Homo sapiens	110-118
12193058-0	2002	Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells.	Polyphenols	35-45	endothelin 1	Bos taurus	62-74
12193058-3	2002	Here we show that an extract of red wine polyphenols causes a concentration-dependent inhibition of endothelin-1 synthesis in cultured bovine aortic endothelial cells.	Polyphenols	41-52	endothelin 1	Bos taurus	100-112
12123743-1	2002	Flavanols--a class of plant polyphenols abundant in tea leaves and grape seeds and skins--have been found to inhibit some matrix-proteases instrumental in inflammation and cancer invasion, such as leukocyte elastase (LE) and gelatinases.	Polyphenols	28-39	elastase, neutrophil expressed	Homo sapiens	217-219
12411199-5	2002	RESULTS: Cyclin D1, Cdk4 and PCNA expressions were significantly inhibited, and the expression of P21(WAF1/CIP1) and GADD45 were significantly induced by tea polyphenols and tea pigments treatments.	Polyphenols	158-169	cyclin D1	Rattus norvegicus	9-18
12143244-0	2002	Suppressive effects of tea polyphenol and conformational changes with receptor for advanced glycation end products (RAGE) expression in human hepatoma cells.	Polyphenols	27-37	advanced glycosylation end-product specific receptor	Homo sapiens	116-120
12393936-2	2002	Previously, one of our laboratories reported that natural ester bond-containing green tea polyphenols (GTPs), such as (-)-epigallocatechin-3-gallate [(-)-EGCG] and (-)-gallocatechin-3-gallate [(-)-GCG], are potent and specific proteasome inhibitors.	Polyphenols	90-101	glucagon	Homo sapiens	155-158
12411199-5	2002	RESULTS: Cyclin D1, Cdk4 and PCNA expressions were significantly inhibited, and the expression of P21(WAF1/CIP1) and GADD45 were significantly induced by tea polyphenols and tea pigments treatments.	Polyphenols	158-169	cyclin-dependent kinase 4	Rattus norvegicus	20-24
12411199-5	2002	RESULTS: Cyclin D1, Cdk4 and PCNA expressions were significantly inhibited, and the expression of P21(WAF1/CIP1) and GADD45 were significantly induced by tea polyphenols and tea pigments treatments.	Polyphenols	158-169	proliferating cell nuclear antigen	Rattus norvegicus	29-33
12411199-5	2002	RESULTS: Cyclin D1, Cdk4 and PCNA expressions were significantly inhibited, and the expression of P21(WAF1/CIP1) and GADD45 were significantly induced by tea polyphenols and tea pigments treatments.	Polyphenols	158-169	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	98-111
12411199-5	2002	RESULTS: Cyclin D1, Cdk4 and PCNA expressions were significantly inhibited, and the expression of P21(WAF1/CIP1) and GADD45 were significantly induced by tea polyphenols and tea pigments treatments.	Polyphenols	158-169	growth arrest and DNA-damage-inducible, alpha	Rattus norvegicus	117-123
12059144-1	2002	Twelve edible plant extracts rich in polyphenols were screened for their potential to inhibit oxidation of low-density lipoprotein (LDL) in vitro and to modulate LDL receptor (LDLr) activity in cultured HepG2 cells.	Polyphenols	37-48	low density lipoprotein receptor	Homo sapiens	162-174
12059144-1	2002	Twelve edible plant extracts rich in polyphenols were screened for their potential to inhibit oxidation of low-density lipoprotein (LDL) in vitro and to modulate LDL receptor (LDLr) activity in cultured HepG2 cells.	Polyphenols	37-48	low density lipoprotein receptor	Homo sapiens	176-180
12049789-4	2002	To investigate the interaction, an NMR study was carried out on the binding of a representative polyphenol, penta-O-galloyl-D-glucopyranose, to a nonapeptide hormone, bradykinin (BDK), where proline accounts for 30% of residues.	Polyphenols	96-106	kininogen 1	Homo sapiens	167-177
12049789-4	2002	To investigate the interaction, an NMR study was carried out on the binding of a representative polyphenol, penta-O-galloyl-D-glucopyranose, to a nonapeptide hormone, bradykinin (BDK), where proline accounts for 30% of residues.	Polyphenols	96-106	kininogen 1	Homo sapiens	179-182
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Polyphenols	67-78	angiotensinogen	Rattus norvegicus	90-104
12161102-0	2002	Green tea polyphenol blocks h(2)o(2)-induced interleukin-8 production from human alveolar epithelial cells.	Polyphenols	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
12161102-4	2002	In the present study, we found that green tea polyphenol significantly inhibited IL-8 production induced by hydrogen peroxide (H(2)O(2)) in human lung alveolar epithelial cells (A549 line).	Polyphenols	46-56	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
12161102-6	2002	We further investigated the effect of green tea polyphenol on these protein kinases, and demonstrated that H(2)O(2)-induced phosphorylation of JNK and p38 but not p44/42 was inhibited by green tea polyphenol in A549 cells.	Polyphenols	48-58	mitogen-activated protein kinase 8	Homo sapiens	143-146
12161102-6	2002	We further investigated the effect of green tea polyphenol on these protein kinases, and demonstrated that H(2)O(2)-induced phosphorylation of JNK and p38 but not p44/42 was inhibited by green tea polyphenol in A549 cells.	Polyphenols	48-58	mitogen-activated protein kinase 14	Homo sapiens	151-154
12161102-6	2002	We further investigated the effect of green tea polyphenol on these protein kinases, and demonstrated that H(2)O(2)-induced phosphorylation of JNK and p38 but not p44/42 was inhibited by green tea polyphenol in A549 cells.	Polyphenols	197-207	mitogen-activated protein kinase 8	Homo sapiens	143-146
12161102-6	2002	We further investigated the effect of green tea polyphenol on these protein kinases, and demonstrated that H(2)O(2)-induced phosphorylation of JNK and p38 but not p44/42 was inhibited by green tea polyphenol in A549 cells.	Polyphenols	197-207	mitogen-activated protein kinase 14	Homo sapiens	151-154
12161102-7	2002	We speculate that green tea polyphenol may inhibit H(2)O(2)-induced IL-8 production from A549 cells through inactivation of JNK and p38.	Polyphenols	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
12161102-7	2002	We speculate that green tea polyphenol may inhibit H(2)O(2)-induced IL-8 production from A549 cells through inactivation of JNK and p38.	Polyphenols	28-38	mitogen-activated protein kinase 8	Homo sapiens	124-127
12161102-7	2002	We speculate that green tea polyphenol may inhibit H(2)O(2)-induced IL-8 production from A549 cells through inactivation of JNK and p38.	Polyphenols	28-38	mitogen-activated protein kinase 14	Homo sapiens	132-135
12053219-2	2002	Epigallocatechin-3-gallate (EGCG) is a representative polyphenol that inhibits the activity of the cyclin-dependent kinases of cdk2 and cdk4.	Polyphenols	54-64	cyclin dependent kinase 2	Homo sapiens	127-131
12053219-2	2002	Epigallocatechin-3-gallate (EGCG) is a representative polyphenol that inhibits the activity of the cyclin-dependent kinases of cdk2 and cdk4.	Polyphenols	54-64	cyclin dependent kinase 4	Homo sapiens	136-140
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Polyphenols	67-78	angiotensinogen	Rattus norvegicus	106-112
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Polyphenols	67-78	mitogen-activated protein kinase 8	Rattus norvegicus	195-218
12004708-8	2002	These data suggest that the chemopreventive effects of green tea polyphenols may involve a p57 mediated survival pathway in normal epithelial cells, while oral carcinoma cells undergo an apoptotic pathway.	Polyphenols	65-76	cyclin dependent kinase inhibitor 1C	Homo sapiens	91-94
12015158-5	2002	Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium.	Polyphenols	19-30	tumor necrosis factor	Homo sapiens	44-52
12015158-5	2002	Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium.	Polyphenols	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
12015158-5	2002	Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium.	Polyphenols	19-30	C-C motif chemokine ligand 2	Homo sapiens	116-121
12015158-5	2002	Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium.	Polyphenols	19-30	intercellular adhesion molecule 1	Homo sapiens	126-132
11923588-0	2002	Grape polyphenols inhibit chronic ethanol-induced COX-2 mRNA expression in rat brain.	Polyphenols	6-17	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	50-55
11906973-9	2002	The RWPC-induced increase in [Ca(2+)](i) was decreased by exposure to ryanodine (30 microM), whereas Provinols and delphinidin-induced increases in [Ca(2+)](i) were decreased by bradykinin (0.1 microM) and thapsigargin (1 microM) pre-treatment.	Polyphenols	101-110	kininogen 1	Bos taurus	178-188
11829627-0	2002	Novel polyphenol molecule isolated from licorice root (Glycrrhiza glabra) induces apoptosis, G2/M cell cycle arrest, and Bcl-2 phosphorylation in tumor cell lines.	Polyphenols	6-16	BCL2 apoptosis regulator	Homo sapiens	121-126
11853888-0	2002	Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols.	Polyphenols	76-87	ATP binding cassette subfamily B member 1	Homo sapiens	39-53
11807963-1	2002	Tea pigments are oxidized products of polyphenols derived from tea leaves (Camellia sinensis).	Polyphenols	38-49	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
11807963-1	2002	Tea pigments are oxidized products of polyphenols derived from tea leaves (Camellia sinensis).	Polyphenols	38-49	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	63-66
11853888-2	2002	In this study, we investigated the effects of green tea polyphenols (GTPs) and their principal catechins on the function of P-glycoprotein (P-gp), which is involved in the multidrug resistance phenotype of cancer cells.	Polyphenols	56-67	ATP binding cassette subfamily B member 1	Homo sapiens	124-138
11853888-2	2002	In this study, we investigated the effects of green tea polyphenols (GTPs) and their principal catechins on the function of P-glycoprotein (P-gp), which is involved in the multidrug resistance phenotype of cancer cells.	Polyphenols	56-67	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
12224378-7	2002	These antioxidative and antiatherogenic effects of pomegranate polyphenols were demonstrated in vitro, as well as in vivo in humans and in atherosclerotic apolipoprotein E deficient mice.	Polyphenols	63-74	apolipoprotein E	Homo sapiens	155-171
11698415-0	2002	Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes.	Polyphenols	10-20	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	39-44
11754570-0	2002	Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures.	Polyphenols	10-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	111-130
11698415-0	2002	Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes.	Polyphenols	10-20	mitogen-activated protein kinase kinase 3	Homo sapiens	46-50
11698415-0	2002	Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes.	Polyphenols	10-20	mitogen-activated protein kinase 14	Homo sapiens	56-59
11698415-0	2002	Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes.	Polyphenols	10-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-99
11698415-0	2002	Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes.	Polyphenols	10-20	involucrin	Homo sapiens	117-127
11756245-0	2002	Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells.	Polyphenols	10-21	insulin like growth factor 1	Homo sapiens	30-35
11756245-0	2002	Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells.	Polyphenols	10-21	AKT serine/threonine kinase 1	Homo sapiens	62-65
11756245-5	2002	Pre-treatment of PrEC and Du145 cells with doses as low as 20 microg/ml of a mixture of black tea polyphenols (BTP) substantially reduced IGF-I-mediated Akt phosphorylation.	Polyphenols	98-109	insulin like growth factor 1	Homo sapiens	138-143
11756245-5	2002	Pre-treatment of PrEC and Du145 cells with doses as low as 20 microg/ml of a mixture of black tea polyphenols (BTP) substantially reduced IGF-I-mediated Akt phosphorylation.	Polyphenols	98-109	AKT serine/threonine kinase 1	Homo sapiens	153-156
11756245-8	2002	Our results indicate that polyphenols from black tea inhibit the IGF-I signal transduction pathway, which has been linked to increased prostate cancer incidence in human populations and, therefore, provide further support for the potential of BTP to prevent prostate cancer.	Polyphenols	26-37	insulin like growth factor 1	Homo sapiens	65-70
12416263-3	2002	Topical application of these polyphenols onto the mouse resulted in inhibition of TPA-induced ear edema and skin epidermal ODC activity.	Polyphenols	29-40	ornithine decarboxylase, structural 1	Mus musculus	123-126
11911242-4	2001	The results showed that the most potent green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), induced p57 in normal keratinocytes in a dosage- and time-dependent manner, while the levels of p57 protein in oral carcinoma cells were unaltered.	Polyphenols	50-60	cyclin dependent kinase inhibitor 1C	Homo sapiens	109-112
11843182-0	2001	Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase.	Polyphenols	0-11	arachidonate 15-lipoxygenase	Homo sapiens	46-61
11911242-0	2001	Chemopreventive effects of green tea polyphenols correlate with reversible induction of p57 expression.	Polyphenols	37-48	cyclin dependent kinase inhibitor 1C	Homo sapiens	88-91
11911242-3	2001	In this study, Western blot analysis combined with cycloheximide treatment was used to examine the effects of green tea polyphenols on the expression levels of p57, a cyclin-dependent kinase and apoptosis inhibitor, in normal human keratinocytes and in the oral carcinoma cell lines SCC25 and OSC2.	Polyphenols	120-131	cyclin dependent kinase inhibitor 1C	Homo sapiens	160-163
11591714-0	2001	Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated phosphatidylinositol 3-kinase-dependent pathway.	Polyphenols	29-40	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	72-101
11591714-1	2001	In this study, we investigated the effect of tea polyphenols, (-)-epigallocatechin-3-gallate or theaflavins, on UVB-induced phosphatidylinositol 3-kinase (PI3K) activation in mouse epidermal JB6 Cl 41 cells.	Polyphenols	49-60	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	124-153
11591714-3	2001	Furthermore, UVB-induced activation of Akt and ribosomal p70 S6 kinase (p70 S6-K), PI3K downstream effectors, were also attenuated by the polyphenols.	Polyphenols	138-149	thymoma viral proto-oncogene 1	Mus musculus	39-42
11591714-3	2001	Furthermore, UVB-induced activation of Akt and ribosomal p70 S6 kinase (p70 S6-K), PI3K downstream effectors, were also attenuated by the polyphenols.	Polyphenols	138-149	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	57-70
11591714-3	2001	Furthermore, UVB-induced activation of Akt and ribosomal p70 S6 kinase (p70 S6-K), PI3K downstream effectors, were also attenuated by the polyphenols.	Polyphenols	138-149	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	72-80
11591714-7	2001	Interestingly, UVB-induced p70 S6-K activation was directly blocked by the addition of (-)-epigallocatechin-3-gallate or theaflavins, whereas these polyphenols showed only a weak inhibition on UVB-induced Akt activation.	Polyphenols	148-159	thymoma viral proto-oncogene 1	Mus musculus	205-208
11780762-2	2001	The metabolic O-methylation of several catechol-containing tea polyphenols by rat liver cytosolic catechol-O-methyltransferase (COMT) has been studied.	Polyphenols	63-74	catechol-O-methyltransferase	Rattus norvegicus	98-126
11780762-2	2001	The metabolic O-methylation of several catechol-containing tea polyphenols by rat liver cytosolic catechol-O-methyltransferase (COMT) has been studied.	Polyphenols	63-74	catechol-O-methyltransferase	Rattus norvegicus	128-132
11780762-12	2001	In summary, the results showed that several catechol-containing tea polyphenols were rapidly O-methylated by rat liver cytosolic COMT.	Polyphenols	68-79	catechol-O-methyltransferase	Rattus norvegicus	129-133
11780762-13	2001	These observations raise the possibility that some of the biological effects of tea polyphenols may be exerted by their O-methylated products or may result from their potential inhibition of the COMT-catalysed O-methylation of endogenous catecholamines and catechol oestrogens.	Polyphenols	84-95	catechol-O-methyltransferase	Rattus norvegicus	195-199
11911242-4	2001	The results showed that the most potent green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), induced p57 in normal keratinocytes in a dosage- and time-dependent manner, while the levels of p57 protein in oral carcinoma cells were unaltered.	Polyphenols	50-60	cyclin dependent kinase inhibitor 1C	Homo sapiens	197-200
11911242-6	2001	The data suggest that the chemopreventive effects of green tea polyphenols may involve p57-mediated cell cycle regulation in normal epithelial cells.	Polyphenols	63-74	cyclin dependent kinase inhibitor 1C	Homo sapiens	87-90
11558561-6	2001	The TNF-inducing potential of the polyphenols producing 50% lysis in murine L929 cells ranged from absent to 138 U/ml at the host cell subtoxic concentration of 50 microg/ml.	Polyphenols	34-45	tumor necrosis factor	Mus musculus	4-7
11518657-13	2001	The multidrug resistance reversion mechanism of tea polyphenol seems to be its inhibition of the activity of P-glycoprotein.	Polyphenols	52-62	ATP binding cassette subfamily B member 1	Homo sapiens	109-123
11502884-2	2001	We previously showed that green tea polyphenols inhibited endotoxin-mediated tumor necrosis factor-alpha (TNF alpha) production by blocking NF-kappa B activation.	Polyphenols	36-47	tumor necrosis factor	Rattus norvegicus	106-115
11502884-5	2001	IEC-6 cells pretreated with an extract of green tea polyphenols (GrTPs; 0--0.4 mg/ml) had diminished TNF alpha-induced IKK and NF-kappa B activity.	Polyphenols	52-63	tumor necrosis factor	Rattus norvegicus	101-110
11504910-0	2001	Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols.	Polyphenols	82-93	tumor necrosis factor receptor superfamily, member 25	Mus musculus	41-46
11374875-0	2001	Green tea polyphenols: novel irreversible inhibitors of dopa decarboxylase.	Polyphenols	10-21	dopa decarboxylase	Homo sapiens	56-74
11435526-0	2001	Green tea polyphenol extract attenuates inflammation in interleukin-2-deficient mice, a model of autoimmunity.	Polyphenols	10-20	interleukin 2	Mus musculus	56-69
11522280-0	2001	Do wine polyphenols modulate p53 gene expression in human cancer cell lines?	Polyphenols	8-19	tumor protein p53	Homo sapiens	29-32
11522280-8	2001	CONCLUSIONS: The observed p53 concentration changes upon stimulation by polyphenols are relatively small, do not follow a uniform pattern in the four cell lines tested, and do not exhibit a dose-response effect.	Polyphenols	72-83	tumor protein p53	Homo sapiens	26-29
11374875-6	2001	Taken together, these findings indicate the active site nature of the interaction of DDC with both polyphenols.	Polyphenols	99-110	dopa decarboxylase	Homo sapiens	85-88
11302173-2	2001	Apples lacking PPO activity might be useful not only for the food industry but also for studies of the metabolism of polyphenols and the function of PPO.	Polyphenols	117-128	polyphenol oxidase, chloroplastic	Malus domestica	15-18
11275421-9	2001	The increase in NQO1 transcription in response to quercetin suggests that dietary plant polyphenols can stimulate transcription of phase II detoxifying systems, potentially through an ARE-dependent mechanism.	Polyphenols	88-99	NAD(P)H quinone dehydrogenase 1	Homo sapiens	16-20
12525092-3	2001	Furthermore, tea polyphenols and tea pigments induced the expression of p21WAF1 protein, inhibited the expression of Bcl-2 protein and induced the expression of Bax protein.	Polyphenols	17-28	BCL2, apoptosis regulator	Rattus norvegicus	117-122
12525092-3	2001	Furthermore, tea polyphenols and tea pigments induced the expression of p21WAF1 protein, inhibited the expression of Bcl-2 protein and induced the expression of Bax protein.	Polyphenols	17-28	BCL2 associated X, apoptosis regulator	Rattus norvegicus	161-164
12525092-4	2001	It is concluded that GST-P was significantly inhibited by tea polyphenols and tea pigments and inhibition of cell proliferation and induction of apoptosis may be the two important mechanisms.	Polyphenols	62-73	glutathione S-transferase pi 1	Rattus norvegicus	21-26
11245257-0	2001	NMR and simulated annealing investigations of bradykinin in presence of polyphenols.	Polyphenols	72-83	kininogen 1	Homo sapiens	46-56
11245257-8	2001	Thus, the biological activities of bradykinin in the presence of polyphenols could be affected.	Polyphenols	65-76	kininogen 1	Homo sapiens	35-45
11020457-0	2000	Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway.	Polyphenols	34-45	nitric oxide synthase 2, inducible	Mus musculus	100-131
11194183-1	2000	Procyanidin B-2 is a polyphenol compound we have identified in apple which acts as a hair-growing factor in the murine model both in vitro and in vivo.	Polyphenols	21-31	immunoglobulin kappa variable 5-2	Homo sapiens	12-15
11244570-7	2001	Double-stranded RNA (dsRNA) and polyphenols of natural origin stimulate IFN production in different populations of immunocytes.	Polyphenols	32-43	interferon alpha 1	Homo sapiens	72-75
11156183-8	2000	To elucidate the mechanisms of green tea polyphenol-induced apoptosis, we measured the activation of an important cell death protein, caspase-3 induced by EGCG, and found that caspase-3 was activated in a dose- and time-dependent manner.	Polyphenols	41-51	caspase 3	Homo sapiens	134-143
11156183-8	2000	To elucidate the mechanisms of green tea polyphenol-induced apoptosis, we measured the activation of an important cell death protein, caspase-3 induced by EGCG, and found that caspase-3 was activated in a dose- and time-dependent manner.	Polyphenols	41-51	caspase 3	Homo sapiens	176-185
11020457-5	2000	The polyphenols quercetin and resveratrol at a micromolar range suppressed iNOS gene expression and NO production, as determined by reverse transcription-polymerase chain reaction and nitrite assay.	Polyphenols	4-15	nitric oxide synthase 2, inducible	Mus musculus	75-79
11008129-5	2000	The inhibitory potency of resveratrol against PKD is in line with the potency of resveratrol observed in cellular systems and with its potency against other purified enzymes and binding proteins that are implicated in the cancer chemopreventive activity of the polyphenol.	Polyphenols	261-271	protein kinase D1	Homo sapiens	46-49
11103814-8	2000	Among the tea polyphenols tested, TF-2 and, to a lesser degree, (-)-epigallocatechin gallate inhibited cyclooxygenase (Cox)-2 gene expression.	Polyphenols	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-125
11023547-5	2000	These polyphenols blocked TPA-induced phosphorylation of IkappaBalpha at Ser32 in the same concentration range.	Polyphenols	6-17	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	57-69
11041245-2	2000	It was found that (i) both bLF and hLF are GL-binding proteins; (ii) purified both proteins function as phosphate acceptors of CK-II; and (iii) this phosphorylation is completely inhibited by two polyphenol-containing anti-oxidant compounds (quercetin and epigallocatechin gallate) at I microm, whereas a glycyrrhetinic acid derivative (oGA) inhibits it at one tenth the concentration of GL.	Polyphenols	196-206	HLF transcription factor, PAR bZIP family member	Homo sapiens	35-38
11051231-0	2000	Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA.	Polyphenols	10-20	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
11051231-1	2000	Cancer chemopreventive effects of polyphenols from green tea (GTP) in mouse models of photocarcinogenesis are established.	Polyphenols	34-45	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	57-60
10950844-0	2000	O-Methylation of tea polyphenols catalyzed by human placental cytosolic catechol-O-methyltransferase.	Polyphenols	21-32	catechol-O-methyltransferase	Homo sapiens	72-100
11052778-0	2000	Decreased superoxide anion production in cultured human promonocyte cells (THP-1) due to polyphenol mixtures from olive oil processing wastewaters.	Polyphenols	89-99	GLI family zinc finger 2	Homo sapiens	75-80
10950844-1	2000	In the present study, we evaluated the metabolic O-methylation of several catechol-containing tea polyphenols by human placental catechol-O-methyltransferase (COMT).	Polyphenols	98-109	catechol-O-methyltransferase	Homo sapiens	129-157
10950844-1	2000	In the present study, we evaluated the metabolic O-methylation of several catechol-containing tea polyphenols by human placental catechol-O-methyltransferase (COMT).	Polyphenols	98-109	catechol-O-methyltransferase	Homo sapiens	159-163
10950844-7	2000	In summary, several catechol-containing tea polyphenols are rapidly O-methylated by human placental cytosolic COMT.	Polyphenols	44-55	catechol-O-methyltransferase	Homo sapiens	110-114
12725062-9	2000	Both tea polyphenols and tea pigments inhibited the over expression of GST Pi in the rats treated with DEN/PH/CCl4.	Polyphenols	9-20	C-C motif chemokine ligand 4	Rattus norvegicus	110-114
10837321-0	2000	Tea polyphenols: prevention of cancer and optimizing health.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
10837321-6	2000	Because the epidemiologic studies and research findings in laboratory animals have shown the chemopreventive potential of tea polyphenols in cancer, the usefulness of tea polyphenols for humans should be evaluated in clinical trials.	Polyphenols	126-137	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	122-125
10837321-9	2000	The usefulness of tea polyphenols may be extended by combining them with other consumer products such as food items and vitamin supplements.	Polyphenols	22-33	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	18-21
10918309-5	2000	Larvae from polyphenol-rich habitats had a higher tolerance for polyphenols and higher midgut cytochrome P450 and esterase activities than larvae from polyphenol-poor habitats.	Polyphenols	12-22	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	105-122
11070355-4	2000	In fact, both polyphenols could serve as substrates for EST.	Polyphenols	14-25	sulfotransferase family 1E member 1	Homo sapiens	56-59
10942531-7	2000	Because the transcription factor AP-1 is important in the process of tumor promotion, the inhibitory effect of these polyphenols on AP-1 activation may further explain the anti-tumor promotion action of these tea constituents.	Polyphenols	117-128	jun proto-oncogene	Mus musculus	33-37
10942531-7	2000	Because the transcription factor AP-1 is important in the process of tumor promotion, the inhibitory effect of these polyphenols on AP-1 activation may further explain the anti-tumor promotion action of these tea constituents.	Polyphenols	117-128	jun proto-oncogene	Mus musculus	132-136
10806303-0	2000	Growth factor-dependent induction of p21(CIP1) by the green tea polyphenol, epigallocatechin gallate.	Polyphenols	64-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	37-40
10806303-0	2000	Growth factor-dependent induction of p21(CIP1) by the green tea polyphenol, epigallocatechin gallate.	Polyphenols	64-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-45
10806303-2	2000	Here, we show that the major polyphenol in green tea, epigallocatechin gallate (EGCG), inhibits S phase entry in epidermal growth factor (EGF) - stimulated MCF10A breast epithelial cells when provided in G0 or mid G1, but not when provided after the late G1 restriction point.	Polyphenols	29-39	epidermal growth factor	Homo sapiens	113-136
10806303-2	2000	Here, we show that the major polyphenol in green tea, epigallocatechin gallate (EGCG), inhibits S phase entry in epidermal growth factor (EGF) - stimulated MCF10A breast epithelial cells when provided in G0 or mid G1, but not when provided after the late G1 restriction point.	Polyphenols	29-39	epidermal growth factor	Homo sapiens	138-141
10660664-0	2000	Green tea extract and its polyphenols markedly inhibit luminol-dependent chemiluminescence activated by peroxynitrite or SIN-1.	Polyphenols	26-37	MAPK associated protein 1	Homo sapiens	121-126
10644043-0	2000	Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3"-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages.	Polyphenols	127-138	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-63
11237202-0	2000	Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression.	Polyphenols	39-50	tumor necrosis factor	Mus musculus	74-83
11237202-1	2000	Among various biochemical and biological activities of tea polyphenols, we believe inhibition of the expression and release of tumor necrosis factor-alpha (TNF-alpha) is crucial, since our study with TNF-alpha-deficient mice has revealed that TNF-alpha is an essential factor in tumor promotion.	Polyphenols	59-70	tumor necrosis factor	Mus musculus	127-154
11237202-1	2000	Among various biochemical and biological activities of tea polyphenols, we believe inhibition of the expression and release of tumor necrosis factor-alpha (TNF-alpha) is crucial, since our study with TNF-alpha-deficient mice has revealed that TNF-alpha is an essential factor in tumor promotion.	Polyphenols	59-70	tumor necrosis factor	Mus musculus	156-165
11237202-1	2000	Among various biochemical and biological activities of tea polyphenols, we believe inhibition of the expression and release of tumor necrosis factor-alpha (TNF-alpha) is crucial, since our study with TNF-alpha-deficient mice has revealed that TNF-alpha is an essential factor in tumor promotion.	Polyphenols	59-70	tumor necrosis factor	Mus musculus	200-209
11237202-1	2000	Among various biochemical and biological activities of tea polyphenols, we believe inhibition of the expression and release of tumor necrosis factor-alpha (TNF-alpha) is crucial, since our study with TNF-alpha-deficient mice has revealed that TNF-alpha is an essential factor in tumor promotion.	Polyphenols	59-70	tumor necrosis factor	Mus musculus	200-209
10889455-1	2000	French maritime pine (Pinus maritima) bark extract (PBE) is a polyphenol-rich food supplement patented under the name of Pycnogenol and known to have strong antioxidant activity and different beneficial effects on human health.	Polyphenols	62-72	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	52-55
10773882-0	2000	Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells.	Polyphenols	4-15	androgen receptor	Homo sapiens	52-69
10773882-3	2000	The tea polyphenol, EGCG, inhibited LNCaP cell growth and the expression of androgen regulated PSA and hK2 genes.	Polyphenols	8-18	RBPJ pseudogene 3	Homo sapiens	103-106
10773882-5	2000	Immunoblotting detected a decrease in androgen receptor protein with treatments of the tea polyphenols EGCG, GCG and theaflavins.	Polyphenols	91-102	androgen receptor	Homo sapiens	38-55
10773882-10	2000	In conclusion, we have described a new property of tea polyphenols that inhibits androgen action by repressing the transcription of the androgen receptor gene.	Polyphenols	55-66	androgen receptor	Homo sapiens	136-153
10679280-0	2000	Green tea polyphenols: novel and potent inhibitors of squalene epoxidase.	Polyphenols	10-21	squalene epoxidase	Rattus norvegicus	54-72
10999444-2	2000	It was found that tea polyphenol had the effect of increasing the activity of superoxide dismutase (SOD) in the brain of the housefly only at the 60th day in the experimental period whereas Lu-Duo-Wei showed more obvious effects on SOD than tea polyphenol irrespective of experimental days.	Polyphenols	22-32	superoxide dismutase	Musca domestica	78-98
10999444-2	2000	It was found that tea polyphenol had the effect of increasing the activity of superoxide dismutase (SOD) in the brain of the housefly only at the 60th day in the experimental period whereas Lu-Duo-Wei showed more obvious effects on SOD than tea polyphenol irrespective of experimental days.	Polyphenols	22-32	superoxide dismutase	Musca domestica	100-103
10999444-2	2000	It was found that tea polyphenol had the effect of increasing the activity of superoxide dismutase (SOD) in the brain of the housefly only at the 60th day in the experimental period whereas Lu-Duo-Wei showed more obvious effects on SOD than tea polyphenol irrespective of experimental days.	Polyphenols	22-32	superoxide dismutase	Musca domestica	232-235
10706406-3	2000	Three polyphenol-containing anti-oxidant compounds [catechin, epigallocatechin gallate (EGCG) and quercetin] inhibited CK-II activity (phosphorylation of these ribosomal P proteins) in a dose-dependent manner in vitro.	Polyphenols	6-16	casein kinase 2 alpha 1	Homo sapiens	119-124
10493515-0	1999	Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.	Polyphenols	95-106	HRas proto-oncogene, GTPase	Homo sapiens	110-115
10786933-0	2000	Cancer chemoprevention by tea polyphenols.	Polyphenols	30-41	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	26-29
10786933-3	2000	The inhibitory effects of tea against carcinogenesis have been attributed to the biologic activities of the polyphenol fraction in tea.	Polyphenols	108-118	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	26-29
10786933-3	2000	The inhibitory effects of tea against carcinogenesis have been attributed to the biologic activities of the polyphenol fraction in tea.	Polyphenols	108-118	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	131-134
10786933-4	2000	This review summarizes experimental data on chemopreventive effects of tea polyphenols in various tumor bioassay systems.	Polyphenols	75-86	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	71-74
10786933-5	2000	Many laboratory studies have demonstrated the inhibitory effects of green tea polyphenols, especially (-)-epigallocatechin-3-gallate (EGCG), on carcinogenesis in animals models.	Polyphenols	78-89	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	74-77
10786933-6	2000	The majority of these studies have been conducted in mouse skin tumor models, where tea polyphenols were used either as oral feeding in drinking water or in direct local application.	Polyphenols	88-99	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	84-87
10786933-7	2000	Most studies used 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet (UV) radiation as the tumor promoter and found anticarcinogenic effects caused by green tea polyphenols.	Polyphenols	168-179	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	164-167
10786933-11	2000	The molecular mechanisms of the cancer chemopreventive effects of tea polyphenols are not completely understood.	Polyphenols	70-81	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	66-69
10786933-12	2000	They are most likely related to the mechanisms of biochemical actions of tea polyphenols, which include antioxidative activities, modulation of xenobiotic metabolite enzymes and inhibition of tumor promotion.	Polyphenols	77-88	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	73-76
10786933-13	2000	In addition, we have also proposed that tea polyphenols function as cancer chemopreventive agents through modulation of mitotic signal transduction.	Polyphenols	44-55	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	40-43
10470285-7	1999	Thus, EGCG and other tea polyphenols may interact with various transcription factors, in addition to AP-1 and NF-kappa B, in nuclei of various cells, resulting in inhibition of TNF-alpha gene expression and TNF-alpha release.	Polyphenols	25-36	nuclear factor kappa B subunit 1	Homo sapiens	110-120
10469619-6	1999	Based on these results, we directed our efforts to separate and identify the individual polyphenols present in GSP and assess their antioxidant activity in terms of inhibition of epidermal lipid peroxidation.	Polyphenols	88-99	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	111-114
10469619-7	1999	Employing HPLC followed by comparison with authentic standards for retention times in HPLC profiles, physiochemical properties and spectral analysis, nine individual polyphenols were identified as catechin, epicatechin, procyanidins B1-B5 and C1 and procyanidin B5-3"-gallate.	Polyphenols	166-177	integrin beta 5	Mus musculus	233-245
10470285-7	1999	Thus, EGCG and other tea polyphenols may interact with various transcription factors, in addition to AP-1 and NF-kappa B, in nuclei of various cells, resulting in inhibition of TNF-alpha gene expression and TNF-alpha release.	Polyphenols	25-36	tumor necrosis factor	Homo sapiens	177-186
10470285-4	1999	Various tea polyphenols derived from green tea and black tea induced growth inhibition and apoptosis of human stomach cancer cell line KATO III, and inhibition of tumor necrosis factor-alpha (TNF-alpha) release from the cells, in the order of (-)-epicatechin gallate (ECG), EGCG, (-)-epigallocatechin (EGC), teaflavins (TF) and (-)-epicatechin (EC).	Polyphenols	12-23	tumor necrosis factor	Homo sapiens	163-190
10470285-4	1999	Various tea polyphenols derived from green tea and black tea induced growth inhibition and apoptosis of human stomach cancer cell line KATO III, and inhibition of tumor necrosis factor-alpha (TNF-alpha) release from the cells, in the order of (-)-epicatechin gallate (ECG), EGCG, (-)-epigallocatechin (EGC), teaflavins (TF) and (-)-epicatechin (EC).	Polyphenols	12-23	tumor necrosis factor	Homo sapiens	192-201
10470285-7	1999	Thus, EGCG and other tea polyphenols may interact with various transcription factors, in addition to AP-1 and NF-kappa B, in nuclei of various cells, resulting in inhibition of TNF-alpha gene expression and TNF-alpha release.	Polyphenols	25-36	tumor necrosis factor	Homo sapiens	207-216
9720210-0	1998	Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells.	Polyphenols	28-38	RB transcriptional corepressor like 2	Rattus norvegicus	73-78
9892181-2	1999	(-)-Epicatechin enhanced apoptosis, growth inhibition of PC-9 cells, and inhibition of tumor necrosis factor-alpha release from BALB/c-3T3 cells by EGCG and other tea polyphenols with a galloyl moiety in a dose-dependent manner.	Polyphenols	167-178	tumor necrosis factor	Homo sapiens	87-114
9868178-12	1998	At a dose of 0.5 g green tea polyphenols/kg body wt, serum TNFalpha was reduced by 80% of control.	Polyphenols	29-40	tumor necrosis factor	Mus musculus	59-67
9868178-14	1998	We conclude that the anti-inflammatory mechanism of green tea polyphenols is mediated at least in part through down-regulation of TNFalpha gene expression by blocking NF-KB activation.	Polyphenols	62-73	tumor necrosis factor	Mus musculus	130-138
10230625-0	1999	Immunostimulation by plant polyphenols: a relationship between tumor necrosis factor-alpha production and tannin structure.	Polyphenols	27-38	tumor necrosis factor	Homo sapiens	63-90
10223207-1	1999	Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells.	Polyphenols	71-81	epidermal growth factor receptor	Homo sapiens	156-194
10223207-1	1999	Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells.	Polyphenols	71-81	epidermal growth factor	Homo sapiens	181-184
10223207-5	1999	In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively.	Polyphenols	44-54	epidermal growth factor	Homo sapiens	104-107
10223207-5	1999	In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively.	Polyphenols	44-54	epidermal growth factor	Mus musculus	166-169
10800471-0	1999	Functional properties of hop polyphenols.	Polyphenols	29-40	HOP homeobox	Homo sapiens	25-28
9868178-6	1998	We postulated that green tea polyphenols regulate TNFalpha gene expression by modulating NF-KB activation through their antioxidant properties.	Polyphenols	29-40	tumor necrosis factor	Mus musculus	50-58
9331105-0	1997	Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.	Polyphenols	99-110	jun proto-oncogene	Mus musculus	37-56
9438575-2	1998	The crude preparation (OTE) of oolong tea polyphenols showed the most prominent effect on caries reduction in SPF rats when OTE was administered in the drinking water beginning 1 day prior to the inoculation of S. sobrinus 6715, when compared with chromatographically isolated polyphenol fractions (OTF1 and OTF6) of OTE.	Polyphenols	42-52	POU class 2 homeobox 1	Rattus norvegicus	299-303
9438575-2	1998	The crude preparation (OTE) of oolong tea polyphenols showed the most prominent effect on caries reduction in SPF rats when OTE was administered in the drinking water beginning 1 day prior to the inoculation of S. sobrinus 6715, when compared with chromatographically isolated polyphenol fractions (OTF1 and OTF6) of OTE.	Polyphenols	42-52	POU class 3 homeobox 1	Rattus norvegicus	308-312
9374426-0	1997	Inhibition of glutathione reductase by plant polyphenols.	Polyphenols	45-56	glutathione-disulfide reductase	Homo sapiens	14-35
9374426-1	1997	The effects of forty-one plant polyphenols on the activity of glutathione reductase (GSH-RD) were studied.	Polyphenols	31-42	glutathione-disulfide reductase	Homo sapiens	62-83
9659588-0	1998	Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression.	Polyphenols	12-23	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	8-11
9659588-8	1998	Growth inhibition by various tea polyphenols has been demonstrated in human lung H661 and H1299 cells.	Polyphenols	33-44	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	29-32
9438575-2	1998	The crude preparation (OTE) of oolong tea polyphenols showed the most prominent effect on caries reduction in SPF rats when OTE was administered in the drinking water beginning 1 day prior to the inoculation of S. sobrinus 6715, when compared with chromatographically isolated polyphenol fractions (OTF1 and OTF6) of OTE.	Polyphenols	42-53	POU class 2 homeobox 1	Rattus norvegicus	299-303
9438575-2	1998	The crude preparation (OTE) of oolong tea polyphenols showed the most prominent effect on caries reduction in SPF rats when OTE was administered in the drinking water beginning 1 day prior to the inoculation of S. sobrinus 6715, when compared with chromatographically isolated polyphenol fractions (OTF1 and OTF6) of OTE.	Polyphenols	42-53	POU class 3 homeobox 1	Rattus norvegicus	308-312
10682639-0	1998	[The antioxidative mechanisms of tea polyphenols in inhibiting tumor promotion by TPA].	Polyphenols	37-48	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	33-36
10682639-0	1998	[The antioxidative mechanisms of tea polyphenols in inhibiting tumor promotion by TPA].	Polyphenols	37-48	promotion susceptibility QTL 1	Mus musculus	82-85
10682639-1	1998	In the mouse study, topical application of green tea polyphenols (GTP) significantly inhibited TPA-induced increasing of epidermal ornithine decarboxylase (ODC) and increased the activities of several antioxidant enzymes (CAT, GR and GST).	Polyphenols	53-64	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	49-52
10682639-1	1998	In the mouse study, topical application of green tea polyphenols (GTP) significantly inhibited TPA-induced increasing of epidermal ornithine decarboxylase (ODC) and increased the activities of several antioxidant enzymes (CAT, GR and GST).	Polyphenols	53-64	promotion susceptibility QTL 1	Mus musculus	95-98
10682639-1	1998	In the mouse study, topical application of green tea polyphenols (GTP) significantly inhibited TPA-induced increasing of epidermal ornithine decarboxylase (ODC) and increased the activities of several antioxidant enzymes (CAT, GR and GST).	Polyphenols	53-64	ornithine decarboxylase, structural 1	Mus musculus	131-154
10682639-1	1998	In the mouse study, topical application of green tea polyphenols (GTP) significantly inhibited TPA-induced increasing of epidermal ornithine decarboxylase (ODC) and increased the activities of several antioxidant enzymes (CAT, GR and GST).	Polyphenols	53-64	ornithine decarboxylase, structural 1	Mus musculus	156-159
9125123-6	1997	The catechin polyphenols were also found to offer protection from peroxynitrite-induced modification of critical amino acids of apolipoprotein B-100 of LDL which contribute towards its surface charge.	Polyphenols	13-24	apolipoprotein B	Homo sapiens	128-148
9281609-2	1997	We investigated the effect of various tea polyphenols and caffeine on the induction of NO synthase (NOS) in thioglycollate-elicited and lipopolysaccharide (LPS)-activated peritoneal macrophages.	Polyphenols	42-53	nitric oxide synthase 2	Homo sapiens	87-98
9255971-3	1997	Ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, was inhibited by 10-20% by these polyphenol compounds.	Polyphenols	114-124	ornithine decarboxylase 1	Homo sapiens	0-23
9255971-3	1997	Ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, was inhibited by 10-20% by these polyphenol compounds.	Polyphenols	114-124	ornithine decarboxylase 1	Homo sapiens	25-28
9230122-6	1997	The glutathione S-transferase (GST) activity of the cancer cells, measured with 1-chloro-2,4-dinitrobenzene, was also inhibited by the polyphenols.	Polyphenols	135-146	glutathione S-transferase kappa 1	Homo sapiens	4-29
9230122-6	1997	The glutathione S-transferase (GST) activity of the cancer cells, measured with 1-chloro-2,4-dinitrobenzene, was also inhibited by the polyphenols.	Polyphenols	135-146	glutathione S-transferase kappa 1	Homo sapiens	31-34
9310136-0	1997	Mechanisms of growth inhibition of human lung cancer cell line, PC-9, by tea polyphenols.	Polyphenols	77-88	proprotein convertase subtilisin/kexin type 9	Homo sapiens	64-68
9255589-10	1997	They are most likely related to the biochemical actions of the tea polyphenols, which include antioxidative activities and inhibition of cell proliferation and of tumor promotion-related activities.	Polyphenols	67-78	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	63-66
9255589-12	1997	The bioavailability and pharmacokinetics of tea polyphenols are being studied in animals and humans to provide a basis for more quantitative analyses on the effect of tea on carcinogenesis.	Polyphenols	48-59	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	44-47
9154941-3	1997	In order to characterize the interaction, NMR studies were performed which involved titrating a series of polyphenols into a synthetic 19-residue PRP fragment.	Polyphenols	106-117	prion protein	Homo sapiens	146-149
9154941-5	1997	Measurement of dissociation constants indicates that the larger and more complex polyphenols interact more strongly with the PRP fragment; the order of binding affinity was determined as procyanidin dimer B-2 &gt; pentagalloylglucose &gt; trigalloylglucose &gt;&gt; proanthocyanidin monomer (-)-epicatechin approximately propyl gallate.	Polyphenols	81-92	prion protein	Homo sapiens	125-128
9154941-7	1997	The more complex polyphenols interact with the PRP fragment in a multidentate fashion; moreover, they self-associate or stack when bound.	Polyphenols	17-28	prion protein	Homo sapiens	47-50
9154941-8	1997	Thus, a model is proposed in which multiple polyphenol/polyphenol and polyphenol/PRP interactions act cooperatively to achieve precipitation.	Polyphenols	44-54	prion protein	Homo sapiens	81-84
8697942-0	1995	[Inhibition of colorectal carcinoma induced by 1, 2-dimethylhydrazine in mice with tea polyphenols].	Polyphenols	87-98	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	83-86
9591194-3	1997	This article summarizes experimental data on chemopreventive effects of tea polyphenols in different tumor bioassay systems.	Polyphenols	76-87	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	72-75
9591194-9	1997	Several epicatechin derivatives (polyphenols) present in green tea have been shown to possess anticarcinogenic activity; the most active is (-)-epigallocatechin-3-gallate, which is also the major constituent of GTP.	Polyphenols	33-44	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	63-66
9591194-12	1997	These properties of tea polyphenols make them effective chemopreventive agents against the initiation, promotion, and progression stages of multistage carcinogenesis.	Polyphenols	24-35	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	20-23
21544351-7	1996	Evidence has also accumulated showing that tea polyphenols prevent tumor promoter- and ultraviolet B-induced inflammatory responses in murine skin.	Polyphenols	47-58	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	43-46
7665919-0	1995	Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols.	Polyphenols	187-198	interleukin 1 alpha	Mus musculus	111-130
7595929-4	1995	Each polyphenol inhibited NADPH-cytochrome P450 reductase activity as measured by reduction of cytochrome C.	Polyphenols	5-15	cytochrome p450 oxidoreductase	Homo sapiens	26-57
7655336-5	1995	The samples were incubated with a mixture of beta-glucuronidase and sulfatase to generate the free form of tea polyphenols.	Polyphenols	111-122	arylsulfatase family member H	Homo sapiens	68-77
7595929-4	1995	Each polyphenol inhibited NADPH-cytochrome P450 reductase activity as measured by reduction of cytochrome C.	Polyphenols	5-15	cytochrome c, somatic	Homo sapiens	95-107
21556548-8	1995	These results indicate that the triphenol structure of the B ring is essential for the E1A-3Y1 cell-specific toxicity of tea polyphenols, and that the decrease in catalase activity is partially responsible for the higher sensitivity of E1A-3Y1 cells against the polyphenols.	Polyphenols	125-136	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	87-90
33794330-7	2021	The polyphenols are able to modulate several inflammation-associated cell signaling pathways, namely nuclear factor-kappa beta (NF-kappaB), mitogen activated protein kinases (MAPKs), Wnt/beta-catenin and phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt) via selective actions on various components of the networks.	Polyphenols	4-15	nuclear factor kappa B subunit 1	Homo sapiens	128-137
21556548-8	1995	These results indicate that the triphenol structure of the B ring is essential for the E1A-3Y1 cell-specific toxicity of tea polyphenols, and that the decrease in catalase activity is partially responsible for the higher sensitivity of E1A-3Y1 cells against the polyphenols.	Polyphenols	262-273	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	236-239
8513446-0	1993	In vitro effects of natural plant polyphenols on the proliferation of normal and abnormal human lymphocytes and their secretions of interleukin-2.	Polyphenols	34-45	interleukin 2	Homo sapiens	132-145
21573520-0	1993	Cytotoxic and cytostatic effects of polyphenols against rat 3y1 fibroblasts transformed by e1a gene of human adenovirus-type-12.	Polyphenols	36-47	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	91-94
21573520-7	1993	These results suggest that the selective toxicity of polyphenols against Ad12-3Y1 and E1A-3Y1 cells is not related to their oxidation velocity but other factors such as the activity of active oxygen-scavenging enzymes.	Polyphenols	53-64	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	86-89
1614996-2	1992	Since tea contains several polyphenols and since several other naturally occurring dietary polyphenols have shown antimutagenic effects in bacteria and anticarcinogenic effects in animal bioassay systems, we studied whether polyphenols extracted from Chinese green tea (GTP) also possess antimutagenic and anticarcinogenic effects.	Polyphenols	27-38	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
21556548-0	1995	E1a-3y1 cell-specific toxicity of tea polyphenols and their killing mechanism.	Polyphenols	38-49	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	0-3
8010991-1	1994	Several novel naturally occurring flavonoids and other polyphenols exerted varying degrees of concentration-dependent inhibition on uncharacterized rat liver glutathione S-transferase (EC 2.5.1.18, GST) isoforms.	Polyphenols	55-66	hematopoietic prostaglandin D synthase	Rattus norvegicus	158-183
2032222-0	1991	Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo.	Polyphenols	95-106	ornithine decarboxylase, structural 1	Mus musculus	37-60
2032222-8	1991	The ability of TA to inhibit by 85% the ODC marker of skin tumor promotion suggests that TA and other polyphenols may be effective not only against tumor initiation and complete carcinogenesis but also against the promotion phase of tumorigenesis.	Polyphenols	102-113	ornithine decarboxylase, structural 1	Mus musculus	40-43
16668224-0	1991	Wound-induced deposition of polyphenols in transgenic plants overexpressing peroxidase.	Polyphenols	28-39	peroxidase N1	Nicotiana tabacum	76-86
16668224-10	1991	This suggests that the availability of peroxidase rather than substrate may delay polyphenol deposition in wounded tissue.	Polyphenols	82-92	peroxidase N1	Nicotiana tabacum	39-49
1953697-0	1991	Lipoxygenase-inhibitory action of antiviral polymeric oxidation products of polyphenols.	Polyphenols	76-87	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	0-12
1953697-1	1991	Various polymeric oxidation products of polyphenols strongly inhibited the purified lipoxygenase of rabbit reticulocytes, whereas the prostaglandin H synthase of sheep vesicular gland was only weakly inhibited.	Polyphenols	40-51	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	84-96
33794330-7	2021	The polyphenols are able to modulate several inflammation-associated cell signaling pathways, namely nuclear factor-kappa beta (NF-kappaB), mitogen activated protein kinases (MAPKs), Wnt/beta-catenin and phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt) via selective actions on various components of the networks.	Polyphenols	4-15	catenin beta 1	Homo sapiens	187-199
33794330-7	2021	The polyphenols are able to modulate several inflammation-associated cell signaling pathways, namely nuclear factor-kappa beta (NF-kappaB), mitogen activated protein kinases (MAPKs), Wnt/beta-catenin and phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt) via selective actions on various components of the networks.	Polyphenols	4-15	protein tyrosine kinase 2 beta	Homo sapiens	238-254
33794330-7	2021	The polyphenols are able to modulate several inflammation-associated cell signaling pathways, namely nuclear factor-kappa beta (NF-kappaB), mitogen activated protein kinases (MAPKs), Wnt/beta-catenin and phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt) via selective actions on various components of the networks.	Polyphenols	4-15	AKT serine/threonine kinase 1	Homo sapiens	261-264
33805467-0	2021	Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound.	Polyphenols	105-115	AKT serine/threonine kinase 1	Homo sapiens	10-13
33805996-8	2021	Some known "oxidative stress modulators", such as melatonin and polyphenols, are suggested to play an important role in the prevention and treatment of cancer, where the activation of NRF2 is reported as a possible underlying mechanism.	Polyphenols	64-75	NFE2 like bZIP transcription factor 2	Homo sapiens	184-188
33808148-4	2021	Indeed, it was found in keratinocytes that carotenoids and polyphenols inhibit UVB-induced NFkappaB activity and release of cytokine IL-6.	Polyphenols	59-70	nuclear factor kappa B subunit 1	Homo sapiens	91-99
33808148-4	2021	Indeed, it was found in keratinocytes that carotenoids and polyphenols inhibit UVB-induced NFkappaB activity and release of cytokine IL-6.	Polyphenols	59-70	interleukin 6	Homo sapiens	133-137
33804820-10	2021	), and curcumin, a polyphenol derived from rhizomes of Curcuma longa L. In this review, the unique function of the CISD2-elevating effect of alpha-ESA and curcumin are particularly emphasized, and these natural compounds are expected to serve as a potential therapeutic target for CNS injuries and diseases.	Polyphenols	19-29	CDGSH iron sulfur domain 2	Homo sapiens	115-120
33806197-2	2021	A recently designed, synthesized and tested hybrid compound between the AChE inhibitor galantamine (GAL) and the antioxidant polyphenol curcumin (CU) showed high AChE inhibition in vitro.	Polyphenols	125-135	acetylcholinesterase	Mus musculus	162-166
33805092-4	2021	Several studies collectively suggests that the intake of polyphenols and their major food sources may exert beneficial effects on improving insulin resistance and related diabetes risk factors, such as inflammation and oxidative stress.	Polyphenols	57-68	insulin	Homo sapiens	140-147
33802972-4	2021	Polyphenols have multiple mechanisms of action and have been reported to decrease cell proliferation, arrest cell cycle and induce apoptosis via the activation of caspase (3, 8 and 9); the loss of mitochondrial membrane potential and the release of cytochrome c.	Polyphenols	0-11	caspase 3	Homo sapiens	163-182
33806914-0	2021	Insight into Inhibitory Mechanism of PDE4D by Dietary Polyphenols Using Molecular Dynamics Simulations and Free Energy Calculations.	Polyphenols	54-65	phosphodiesterase 4D	Homo sapiens	37-42
33806914-4	2021	In the present study, a thorough computational investigation consisting of molecular docking, molecular dynamics (MD) simulations, and binding free energy calculations based on the linear response approximation (LRA) method was performed to study dietary polyphenols as potential PDE4D inhibitors.	Polyphenols	255-266	phosphodiesterase 4D	Homo sapiens	280-285
33806914-9	2021	The uncovered molecular inhibitory mechanisms of four investigated natural polyphenols, curcumin, 6-gingerol, capsaicin, and resveratrol, form the basis for the design of novel PDE4D inhibitors for the treatment of Alzheimer"s disease with a potentially wider therapeutic window and fewer adverse side effects.	Polyphenols	75-86	phosphodiesterase 4D	Homo sapiens	177-182
33808759-0	2021	Anti-Inflammatory Effects of a Polyphenol, Catechin-7,4"-O-Digallate, from Woodfordia uniflora by Regulating NF-kappaB Signaling Pathway in Mouse Macrophages.	Polyphenols	31-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	109-118
33802972-4	2021	Polyphenols have multiple mechanisms of action and have been reported to decrease cell proliferation, arrest cell cycle and induce apoptosis via the activation of caspase (3, 8 and 9); the loss of mitochondrial membrane potential and the release of cytochrome c.	Polyphenols	0-11	cytochrome c, somatic	Homo sapiens	249-261
33802972-5	2021	Polyphenols have been shown to suppress activation of transcription factors, including NF-kB and STAT3.	Polyphenols	0-11	signal transducer and activator of transcription 3	Homo sapiens	97-102
33803136-7	2021	Interestingly, representative PPEP polyphenols mediated the induction of Nrf2 target genes cell-autonomously in adipocytes, suggesting that this induction may be related to the specific polyphenol content of PPEP.	Polyphenols	35-46	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
33803136-7	2021	Interestingly, representative PPEP polyphenols mediated the induction of Nrf2 target genes cell-autonomously in adipocytes, suggesting that this induction may be related to the specific polyphenol content of PPEP.	Polyphenols	35-45	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
33232763-0	2021	Tea polyphenols inhibit the growth and virulence of ETEC K88.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
33762947-2	2021	Salvianolic acid A (SAA), a natural polyphenol extract of Salvia miltiorrhiza Bunge (Danshen in China), is known to be cardioprotective.	Polyphenols	36-46	serum amyloid A cluster	Mus musculus	20-23
33232763-4	2021	Tea polyphenols have numerous important biological functions, including antibacterial, antiviral, antioxidative, anti-inflammatory, and antihypertensive effects.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
33232763-6	2021	Pretreating with tea polyphenols attenuated the symptoms induced by ETEC K88.	Polyphenols	21-32	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	17-20
33232763-7	2021	Furthermore, in a cell adherence assay, tea polyphenols inhibited ETEC K88 adherence to IPEC-J2 cells.	Polyphenols	44-55	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	40-43
33232763-7	2021	Furthermore, in a cell adherence assay, tea polyphenols inhibited ETEC K88 adherence to IPEC-J2 cells.	Polyphenols	44-55	ETEC	Sus scrofa	66-70
33232763-9	2021	However, when cells were pretreated with tea polyphenols, claudin-1 mRNA and protein levels were higher than those in cells without pretreatment upon cell infection with ETEC K88.	Polyphenols	45-56	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	41-44
33232763-9	2021	However, when cells were pretreated with tea polyphenols, claudin-1 mRNA and protein levels were higher than those in cells without pretreatment upon cell infection with ETEC K88.	Polyphenols	45-56	claudin 1	Sus scrofa	58-67
33232763-9	2021	However, when cells were pretreated with tea polyphenols, claudin-1 mRNA and protein levels were higher than those in cells without pretreatment upon cell infection with ETEC K88.	Polyphenols	45-56	ETEC	Sus scrofa	170-174
33232763-10	2021	TLR2 mRNA levels were also higher following cell infection with ETEC K88 when cells were pretreated with tea polyphenols.	Polyphenols	109-120	TLR2	Sus scrofa	0-4
33766446-0	2021	Polyphenol treatments increase elastin and collagen deposition by human dermal fibroblasts; Implications to improve skin health.	Polyphenols	0-10	elastin	Homo sapiens	31-38
33766446-6	2021	OBJECTIVE: We hypothesize that polyphenols may help coacervate cell secreted TE due to its elastin binding property and increase insoluble elastin in human dermal fibroblasts (HDFs).	Polyphenols	31-42	elastin	Homo sapiens	91-98
33232763-10	2021	TLR2 mRNA levels were also higher following cell infection with ETEC K88 when cells were pretreated with tea polyphenols.	Polyphenols	109-120	ETEC	Sus scrofa	64-68
33766446-6	2021	OBJECTIVE: We hypothesize that polyphenols may help coacervate cell secreted TE due to its elastin binding property and increase insoluble elastin in human dermal fibroblasts (HDFs).	Polyphenols	31-42	elastin	Homo sapiens	139-146
33232763-10	2021	TLR2 mRNA levels were also higher following cell infection with ETEC K88 when cells were pretreated with tea polyphenols.	Polyphenols	109-120	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	105-108
33766446-7	2021	Increase in TE production by short term UV exposure may further improve elastin deposition by polyphenols.	Polyphenols	94-105	elastin	Homo sapiens	72-79
33766446-9	2021	RESULTS: Polyphenols increased insoluble elastin deposition several folds as compared to control untreated cells.	Polyphenols	9-20	elastin	Homo sapiens	41-48
33232763-11	2021	These data revealed that tea polyphenols could increase the barrier integrity of IPEC-J2 cells by upregulating expression of claudin-1 through activation of TLR2.	Polyphenols	29-40	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	25-28
33766446-12	2021	When polyphenols were introduced with UVA exposure, insoluble elastin deposition was further enhanced in HDFs (30-45-fold increase).	Polyphenols	5-16	elastin	Homo sapiens	62-69
33232763-11	2021	These data revealed that tea polyphenols could increase the barrier integrity of IPEC-J2 cells by upregulating expression of claudin-1 through activation of TLR2.	Polyphenols	29-40	claudin 1	Sus scrofa	125-134
33766446-15	2021	CONCLUSIONS: Polyphenols in combination with short exposure to UVA light increase extracellular matrix deposition of elastin and collagen and may improve skin properties.	Polyphenols	13-24	elastin	Homo sapiens	117-124
33232763-11	2021	These data revealed that tea polyphenols could increase the barrier integrity of IPEC-J2 cells by upregulating expression of claudin-1 through activation of TLR2.	Polyphenols	29-40	TLR2	Sus scrofa	157-161
33232763-12	2021	Tea polyphenols had beneficial effects on epithelial barrier function.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
33232763-13	2021	Therefore, tea polyphenols could be used as a novel strategy to control and treat pig infections caused by ETEC K88.	Polyphenols	15-26	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	11-14
32795580-0	2020	Date palm (Phoenix dactylifera L.) fruit"s polyphenols as potential inhibitors for human amylin fibril formation and toxicity in type 2 diabetes.	Polyphenols	43-54	islet amyloid polypeptide	Homo sapiens	89-95
33589649-19	2021	In our comparison studies, we show that percepta has the most potent ability to disaggregate/reduce Abeta 1-42 fibrils and tau protein paired helical/straight filaments as demonstrated by a variety of methods most likely due to the specific polyphenol content in PTI-00703 cat"s claw (i.e. polyphenols and proanthocyanidins) as we have previously shown (Snow et al.	Polyphenols	241-251	cathepsin S	Mus musculus	273-278
32795580-4	2020	METHOD: In this study, we used a broad biophysical approach, using cell biology techniques and bioinformatic tools, to demonstrate that various polyphenols from date palm (Phoenix dactylifera L.) fruit significantly inhibited hIAPP aggregation and cytotoxicity.	Polyphenols	144-155	islet amyloid polypeptide	Homo sapiens	226-231
32795580-5	2020	RESULT: Our results suggest that all of the polyphenols showed inhibitory effects, albeit varied, on the formation of toxic hIAPP amyloids.	Polyphenols	44-55	islet amyloid polypeptide	Homo sapiens	124-129
32795580-6	2020	Correlation between cell viability assay, permeabilization of synthetic phospholipid vesicles tests, and ANS florescence measurements, revealed that both classes of polyphenols protected INS-1E cells from the toxicity of amylin aggregates.	Polyphenols	165-176	islet amyloid polypeptide	Rattus norvegicus	221-227
33591473-8	2021	An increase in the activity of SOD, POX and polyphenols content, with the most pronounced changes in POX activity and polyphenols concentration, could minimize the cellular damage caused by flooding.	Polyphenols	118-129	superoxide dismutase	Zea mays	31-34
32795580-7	2020	Docking results showed that the used polyphenols physically interacted with both hIAPP amyloidogenic region (residues Ser20-Ser29) and the non-amyloidogenic regions via hydrophobic and hydrogen interactions, thus reducing aggregation levels.	Polyphenols	37-48	islet amyloid polypeptide	Homo sapiens	81-86
34890728-0	2022	Polyphenols extracted from Enteromorpha clathrata alleviates inflammation in lipopolysaccharide-induced RAW 264.7 cells by inhibiting the MAPKs/NF-kappaB signaling pathways.	Polyphenols	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-153
23554028-7	2013	The results obtained, other than confirming the anti-oxidant properties of cocoa, demonstrate that cocoa polyphenols triggers neuroprotection by activating BDNF survival pathway, both on Abeta plaque treated cells and on Abeta oligomers treated cells, resulting in the counteraction of neurite dystrophy.	Polyphenols	105-116	brain derived neurotrophic factor	Homo sapiens	156-160
20368373-1	2009	BACKGROUND: Tea polyphenols, as both insulin potentiating factors and antioxidants, are postulated to act in preventing the metabolic syndrome, which is characterized by insulin resistance, dyslipidemia, and increased oxidative stress.	Polyphenols	16-27	insulin	Homo sapiens	37-44
20368373-1	2009	BACKGROUND: Tea polyphenols, as both insulin potentiating factors and antioxidants, are postulated to act in preventing the metabolic syndrome, which is characterized by insulin resistance, dyslipidemia, and increased oxidative stress.	Polyphenols	16-27	insulin	Homo sapiens	170-177
34953246-7	2022	This study provided a novel enzyme-induced approach to modulate the physicochemical properties of SPI binding polyphenol.	Polyphenols	110-120	chromogranin A	Homo sapiens	98-101
33233211-0	2020	Effect of polyphenols on HER2-positive breast cancer and related miRNAs: Epigenomic regulation.	Polyphenols	10-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	25-29
33233211-6	2020	Evidence has shown that dietary polyphenols modulate HER2-positive breast cancer-associated microRNAs, resulting in a reduction of tumor growth and metastatic potential, and chemosensitivity restoration without displaying toxicity-derived adverse effects.	Polyphenols	32-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
33233211-7	2020	These beneficial properties make polyphenols a potential therapeutic approach for HER2-positive breast cancer patients in the clinical setting, alone or in combination with conventional therapies.	Polyphenols	33-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-86
34890728-9	2022	CONCLUSIONS: These findings indicated for the first time the correlation between the anti-inflammatory activity of ECPs and NF-kappaB and MAPK signaling pathways, suggesting that polyphenol-enriched organic fraction of E. clathrata could be potential candidate as therapeutic agent for treating inflammatory diseases.	Polyphenols	179-189	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	124-133
34896434-0	2022	Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways.	Polyphenols	6-16	AKT serine/threonine kinase 1	Homo sapiens	142-145
34929315-5	2022	Herein, we review the hormetic effects of polyphenols and nanoincapsulated-polyphenols in chemoprevention and treatment of brain tumors via activation or inhibition of Nrf2/vitagenes to suppress carcinogenesis in the early stages and inhibit its progression.	Polyphenols	42-53	NFE2 like bZIP transcription factor 2	Homo sapiens	168-172
34929315-5	2022	Herein, we review the hormetic effects of polyphenols and nanoincapsulated-polyphenols in chemoprevention and treatment of brain tumors via activation or inhibition of Nrf2/vitagenes to suppress carcinogenesis in the early stages and inhibit its progression.	Polyphenols	75-86	NFE2 like bZIP transcription factor 2	Homo sapiens	168-172
34775124-3	2022	Here, we designed a theranostic nanoplatform, named FCS/GCS, by incorporating amphiphilic polymer skeletal (P-SS-D), cinnamaldehyde prodrug (CA-OH) and iron ions (Fe3+)/gadolinium ions (Gd3+) via chelation reactions between Fe3+/Gd3+ and polyphenols.	Polyphenols	238-249	GRDX	Homo sapiens	186-189
34775124-3	2022	Here, we designed a theranostic nanoplatform, named FCS/GCS, by incorporating amphiphilic polymer skeletal (P-SS-D), cinnamaldehyde prodrug (CA-OH) and iron ions (Fe3+)/gadolinium ions (Gd3+) via chelation reactions between Fe3+/Gd3+ and polyphenols.	Polyphenols	238-249	GRDX	Homo sapiens	229-232
34399273-0	2022	Number of galloyl moiety and intramolecular bonds in galloyl-based polyphenols affect their interaction with alpha-glucosidase.	Polyphenols	67-78	sucrase-isomaltase	Homo sapiens	109-126
34399273-5	2022	All polyphenols that had inhibitory effects quenched alpha-glucosidase fluorescence in a static mode through forming a polyphenol-enzyme complex.	Polyphenols	4-15	sucrase-isomaltase	Homo sapiens	53-70
34399273-5	2022	All polyphenols that had inhibitory effects quenched alpha-glucosidase fluorescence in a static mode through forming a polyphenol-enzyme complex.	Polyphenols	119-129	sucrase-isomaltase	Homo sapiens	53-70
34749194-0	2022	Biomimetic polyphenol-coated nanoparticles by Co-assembly of mTOR inhibitor and photosensitizer for synergistic chemo-photothermal therapy.	Polyphenols	11-21	mechanistic target of rapamycin kinase	Homo sapiens	61-65
34815622-4	2022	Epigallocatechin-3-gallate - a polyphenol from tea - effectively has been shown to inhibit the activity of SARS-CoV-2 as it blocked binding of coronavirus 2 to human angiotensin converting enzyme 2, decreased the expression of inflammatory factors in the blood, including tumor necrosis factor-alpha and interleukin-6, and significantly increased the overall fertilization efficiency in animals.	Polyphenols	31-41	angiotensin converting enzyme 2	Homo sapiens	166-197
34815622-4	2022	Epigallocatechin-3-gallate - a polyphenol from tea - effectively has been shown to inhibit the activity of SARS-CoV-2 as it blocked binding of coronavirus 2 to human angiotensin converting enzyme 2, decreased the expression of inflammatory factors in the blood, including tumor necrosis factor-alpha and interleukin-6, and significantly increased the overall fertilization efficiency in animals.	Polyphenols	31-41	tumor necrosis factor	Homo sapiens	272-299
34815622-4	2022	Epigallocatechin-3-gallate - a polyphenol from tea - effectively has been shown to inhibit the activity of SARS-CoV-2 as it blocked binding of coronavirus 2 to human angiotensin converting enzyme 2, decreased the expression of inflammatory factors in the blood, including tumor necrosis factor-alpha and interleukin-6, and significantly increased the overall fertilization efficiency in animals.	Polyphenols	31-41	interleukin 6	Homo sapiens	304-317
34802178-0	2022	Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention.	Polyphenols	36-47	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	10-14
34802178-5	2022	Recent studies indicate that AMPK also plays an important role in cancer prevention and regulating cancer-related genes and pathways, and dietary polyphenols can significantly regulate AMPK activity.	Polyphenols	146-157	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	29-33
34802178-5	2022	Recent studies indicate that AMPK also plays an important role in cancer prevention and regulating cancer-related genes and pathways, and dietary polyphenols can significantly regulate AMPK activity.	Polyphenols	146-157	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	185-189
34802178-6	2022	In this review, we systemically summarized the progress of dietary polyphenols preventing carcinogenesis via AMPK pathway.	Polyphenols	67-78	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	109-113
34802178-8	2022	AMPK pathway modulated by different dietary polyphenols affects pathways and target genes were summarized.	Polyphenols	44-55	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
34802178-9	2022	Dietary polyphenols exert anti-cancer effect through the target molecules regulated by AMPK, which broadens our understanding of polyphenols anti-cancer mechanisms and provides value reference for the investigators of the novel field.	Polyphenols	8-19	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	87-91
34802178-9	2022	Dietary polyphenols exert anti-cancer effect through the target molecules regulated by AMPK, which broadens our understanding of polyphenols anti-cancer mechanisms and provides value reference for the investigators of the novel field.	Polyphenols	129-140	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	87-91
34896434-0	2022	Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways.	Polyphenols	6-16	vascular endothelial growth factor A	Homo sapiens	151-155
34979103-4	2022	This study establishes the ability of the polyphenol compound epigallocatechin gallate, a principal component of green tea, to facilitate the extracellular formation of elastin fibers in vascular smooth muscle cells derived from human induced pluripotent stem cells.	Polyphenols	42-52	elastin	Homo sapiens	169-176
34785822-0	2022	Dietary polyphenols mitigate SARS-CoV-2 main protease (Mpro) - Molecular Dynamics, Molecular Mechanics, and Density Functional Theory Investigations.	Polyphenols	8-19	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	55-59
34785822-3	2022	In this study, the inhibitory potential of fifty (50) dietary polyphenols against Coronavirus (SARS-CoV-2) main protease (Mpro) was conducted using Autodock Vina Molecular docking tool.	Polyphenols	62-73	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	122-126
34863710-0	2022	The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-kappaB pathway exert anti-inflammatory activity in ischemic stroke.	Polyphenols	12-25	toll like receptor 4	Homo sapiens	70-74
34863710-0	2022	The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-kappaB pathway exert anti-inflammatory activity in ischemic stroke.	Polyphenols	12-25	nuclear factor kappa B subunit 1	Homo sapiens	75-84
34863710-11	2022	Thus, this review focuses on the anti-inflammatory properties of dietary (poly)phenols and discusses their effects on the polarization of microglia through modulating TLR4/NF-kappaB signaling pathway in the ischemic stroke.	Polyphenols	74-86	toll like receptor 4	Homo sapiens	167-171
34863710-11	2022	Thus, this review focuses on the anti-inflammatory properties of dietary (poly)phenols and discusses their effects on the polarization of microglia through modulating TLR4/NF-kappaB signaling pathway in the ischemic stroke.	Polyphenols	74-86	nuclear factor kappa B subunit 1	Homo sapiens	172-181
34688163-6	2022	Hence, this study could be a reminiscent aspect in understanding the inhibitory role of key polyphenols against the mutant TTR aggregates, which could be an aid towards structure-based drug design in the upcoming research era on familial amyloid disorders.	Polyphenols	92-103	transthyretin	Homo sapiens	123-126
34825416-1	2022	Ample evidence highlights the potential benefits of polyphenols in health status especially in obesity-related metabolic disorders such as insulin resistance, type 2 diabetes, and cardiovascular diseases.	Polyphenols	52-63	insulin	Homo sapiens	139-146
34896434-0	2022	Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways.	Polyphenols	6-16	mechanistic target of rapamycin kinase	Homo sapiens	146-150
34959709-0	2021	Mulberry Leaf Polyphenol Extract and Rutin Induces Autophagy Regulated by p53 in Human Hepatoma HepG2 Cells.	Polyphenols	14-24	tumor protein p53	Homo sapiens	74-77
34943127-4	2021	Previous studies have shown that dietary carotenoids and polyphenols activate the cell"s antioxidant defense system by increasing antioxidant response element/Nrf2 (ARE/Nrf2) transcriptional activity and reducing the inflammatory response.	Polyphenols	57-68	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163
34943127-4	2021	Previous studies have shown that dietary carotenoids and polyphenols activate the cell"s antioxidant defense system by increasing antioxidant response element/Nrf2 (ARE/Nrf2) transcriptional activity and reducing the inflammatory response.	Polyphenols	57-68	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
34959709-3	2021	We previously revealed that apoptosis was mediated in p53-negative Hep3B cells, and mulberry leaf polyphenol extract (MLPE) induced autophagy in p53-transfected Hep3B cells.	Polyphenols	98-108	tumor protein p53	Homo sapiens	145-148
34944521-0	2021	In Silico Approaches to Identify Polyphenol Compounds as alpha-Glucosidase and alpha-Amylase Inhibitors against Type-II Diabetes.	Polyphenols	33-43	sucrase-isomaltase	Homo sapiens	57-74
34943092-4	2021	It was found that chia seeds are a rich source of bioactive ingredients with beneficial effects on human health-especially polyphenols.	Polyphenols	123-134	chitinase acidic	Homo sapiens	18-22
34924813-2	2021	It was found that the level of metastasis-associated gene 1 (MTA1)/histone deacetylase 1 (HDAC1) protein complex was downregulated by polyphenols in several human disorders.	Polyphenols	134-145	metastasis associated 1	Homo sapiens	31-59
34970150-6	2021	Polyphenols may exert antidiabetic effects via their ability to inhibit hA aggregation, and to modulate oxidative stress, inflammation, and other pathways that are beta-cell-protective or insulin-sensitizing.	Polyphenols	0-11	insulin	Homo sapiens	188-195
34948195-5	2021	The present study aimed to assess the role of Ellagic acid (EA), a polyphenol found in many fruits, on alpha-syn aggregation and toxicity.	Polyphenols	67-77	synuclein alpha	Homo sapiens	103-112
34940045-8	2021	PAP+ gel on used on polyphenol stains was superior to 6% HP.	Polyphenols	20-30	PDGFA associated protein 1	Homo sapiens	0-3
34924813-2	2021	It was found that the level of metastasis-associated gene 1 (MTA1)/histone deacetylase 1 (HDAC1) protein complex was downregulated by polyphenols in several human disorders.	Polyphenols	134-145	metastasis associated 1	Homo sapiens	61-65
34944489-4	2021	The goal of this investigation was to evaluate the effect of the polyphenol epigallocatechin-3-gallate (EGCG) on cholinergic-like neurons (ChLNs) bearing the mutation E280A in PRESENILIN 1 (PSEN1 E280A).	Polyphenols	65-75	presenilin 1	Homo sapiens	190-195
34924813-2	2021	It was found that the level of metastasis-associated gene 1 (MTA1)/histone deacetylase 1 (HDAC1) protein complex was downregulated by polyphenols in several human disorders.	Polyphenols	134-145	histone deacetylase 1	Homo sapiens	90-95
34959345-0	2021	Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity.	Polyphenols	11-22	ATP binding cassette subfamily B member 1	Homo sapiens	26-40
34944489-8	2021	Although EGCG did not reduce (e)Abeta42, the polyphenol reversed Ca2+ influx dysregulation as a response to acetylcholine (ACh) stimuli in PSEN1 E280A ChLNs, inhibited the activation of transcription factor NF-kappaB, and reduced the secretion of pro-inflammatory IL-6 in wild-type astrocyte-like cells (ALCs) when exposed to mutant ChLNs culture supernatant.	Polyphenols	45-55	presenilin 1	Homo sapiens	139-144
34944489-8	2021	Although EGCG did not reduce (e)Abeta42, the polyphenol reversed Ca2+ influx dysregulation as a response to acetylcholine (ACh) stimuli in PSEN1 E280A ChLNs, inhibited the activation of transcription factor NF-kappaB, and reduced the secretion of pro-inflammatory IL-6 in wild-type astrocyte-like cells (ALCs) when exposed to mutant ChLNs culture supernatant.	Polyphenols	45-55	nuclear factor kappa B subunit 1	Homo sapiens	207-216
34944489-8	2021	Although EGCG did not reduce (e)Abeta42, the polyphenol reversed Ca2+ influx dysregulation as a response to acetylcholine (ACh) stimuli in PSEN1 E280A ChLNs, inhibited the activation of transcription factor NF-kappaB, and reduced the secretion of pro-inflammatory IL-6 in wild-type astrocyte-like cells (ALCs) when exposed to mutant ChLNs culture supernatant.	Polyphenols	45-55	interleukin 6	Homo sapiens	264-268
34946521-0	2021	Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp).	Polyphenols	0-11	rna dependent rna polymerase	None	50-78
34946521-0	2021	Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp).	Polyphenols	0-11	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	80-84
34946521-2	2021	Our previous study revealed the inhibitory mechanisms of polyphenols against DNA polymerase alpha and HIV reverse transcriptase to show that polyphenols can block DNA elongation by competing with the incoming NTPs.	Polyphenols	57-68	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	77-97
34946521-2	2021	Our previous study revealed the inhibitory mechanisms of polyphenols against DNA polymerase alpha and HIV reverse transcriptase to show that polyphenols can block DNA elongation by competing with the incoming NTPs.	Polyphenols	141-152	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	77-97
34946521-3	2021	Here we applied computational approaches to examine if some polyphenols can also inhibit RNA polymerase (RdRp) in SARS-CoV-2, and we identified some better candidates than remdesivir, the FDA-approved drug against RdRp, in terms of estimated binding affinities.	Polyphenols	60-71	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	105-109
34959345-13	2021	Generally, our data demonstrate diverse interactions of the tested polyphenols with Pgp.	Polyphenols	67-78	ATP binding cassette subfamily B member 1	Homo sapiens	84-87
34959345-14	2021	Our results also call attention to the potential risks of drug-drug interactions (DDIs) associated with the consumption of dietary polyphenols concurrently with chemotherapy treatment involving Pgp substrate/inhibitor drugs.	Polyphenols	131-142	ATP binding cassette subfamily B member 1	Homo sapiens	194-197
34959345-0	2021	Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity.	Polyphenols	11-22	ATP binding cassette subfamily B member 1	Homo sapiens	42-47
34959345-5	2021	Previous studies have shown that certain polyphenols interact with human Pgp.	Polyphenols	41-52	ATP binding cassette subfamily B member 1	Homo sapiens	73-76
34959345-6	2021	We tested the effect of 15 polyphenols of sour cherry origin on the basal and verapamil-stimulated ATPase activity of Pgp, calcein-AM and daunorubicin transport as well as on the conformation of Pgp using the conformation sensitive UIC2 mAb.	Polyphenols	27-38	ATP binding cassette subfamily B member 1	Homo sapiens	118-121
34737813-0	2021	Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.	Polyphenols	4-15	mitogen-activated protein kinase kinase kinase 10	Mus musculus	88-91
34737813-0	2021	Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.	Polyphenols	4-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96
34737813-0	2021	Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.	Polyphenols	4-15	kelch-like ECH-associated protein 1	Mus musculus	110-115
34737813-0	2021	Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.	Polyphenols	4-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
34737813-0	2021	Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells.	Polyphenols	4-15	heme oxygenase 1	Mus musculus	121-125
34227035-10	2021	Then, we performed a literature survey to provide protective mechanisms for the TRKB signalling pathway activation, mediated through polyphenols.	Polyphenols	133-144	neurotrophic receptor tyrosine kinase 2	Homo sapiens	80-84
34835123-7	2021	We further show direct evidence of the effectiveness of these protocols by utilizing them to test the effectiveness of the polyphenol drug, Rottlerin, at inhibiting Zika virus infection and death of neuronal cell lines.	Polyphenols	123-133	rottlerin	None	140-149
34673854-0	2021	Protective action of pomegranate peel polyphenols in type 2 diabetic rats via the translocation of Nrf2 and FoxO1 regulated by the PI3K/Akt pathway.	Polyphenols	38-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	99-103
34829115-8	2021	CHS-LPP film packaging effectively inhibited the browning of fresh-cut apple and the reduction of polyphenol content in apple juice caused by polyphenol oxidase (PPO)-mediated oxidation during storage.	Polyphenols	98-108	polyphenol oxidase, chloroplastic	Malus domestica	142-160
34829115-8	2021	CHS-LPP film packaging effectively inhibited the browning of fresh-cut apple and the reduction of polyphenol content in apple juice caused by polyphenol oxidase (PPO)-mediated oxidation during storage.	Polyphenols	98-108	polyphenol oxidase, chloroplastic	Malus domestica	162-165
34673854-0	2021	Protective action of pomegranate peel polyphenols in type 2 diabetic rats via the translocation of Nrf2 and FoxO1 regulated by the PI3K/Akt pathway.	Polyphenols	38-49	forkhead box O1	Rattus norvegicus	108-113
34673854-0	2021	Protective action of pomegranate peel polyphenols in type 2 diabetic rats via the translocation of Nrf2 and FoxO1 regulated by the PI3K/Akt pathway.	Polyphenols	38-49	AKT serine/threonine kinase 1	Rattus norvegicus	136-139
34829046-0	2021	Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation.	Polyphenols	34-44	kelch-like ECH-associated protein 1	Mus musculus	93-98
34597024-4	2021	In this study, different types of polyphenols, including gallic acid (GA), tannic acid (TA), and cyanidin-3-O-glucoside (C3G), were individually used to synthesize the grafted MCC-g-polyphenol conjugates by the free-radical grafting method.	Polyphenols	182-192	Rap guanine nucleotide exchange factor 1	Homo sapiens	121-124
34829046-0	2021	Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation.	Polyphenols	34-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
34768882-7	2021	Based on these findings, it can be concluded that this polyphenol may provide effective protection against BP-3-induced disturbances in skin cells, which may have important clinical implications.	Polyphenols	55-65	BP3	Homo sapiens	107-111
34795590-2	2021	Coffee peel (CP) preparations are consumed as beverages, and their total polyphenol or flavonoid content and their effect on oxidative stress-induced human mesenchymal stem cells (hMSCs) are poorly understood.	Polyphenols	73-83	carboxypeptidase E	Homo sapiens	13-15
34411613-0	2021	Nanoparticle impregnated self-supporting protein gel for enhanced reduction in oxidative stress: A molecular dynamics insight for lactoferrin-polyphenol interaction.	Polyphenols	142-152	lactotransferrin	Rattus norvegicus	130-141
34778638-3	2021	In addition, our previous work suggested that a number of natural monomeric and oligomeric polyphenols interact with OXER1, acting similar to testosterone.	Polyphenols	91-102	oxoeicosanoid receptor 1	Homo sapiens	117-122
34744708-5	2021	We describe the protein modifications induced by these polyphenols and their effect on the central elements of several signaling pathways including PI3K, Akt, mTOR, RAS, and MAPK and particularly those affecting the tumor suppressor p53 protein.	Polyphenols	55-66	AKT serine/threonine kinase 1	Homo sapiens	154-157
34744708-5	2021	We describe the protein modifications induced by these polyphenols and their effect on the central elements of several signaling pathways including PI3K, Akt, mTOR, RAS, and MAPK and particularly those affecting the tumor suppressor p53 protein.	Polyphenols	55-66	mechanistic target of rapamycin kinase	Homo sapiens	159-163
34744708-5	2021	We describe the protein modifications induced by these polyphenols and their effect on the central elements of several signaling pathways including PI3K, Akt, mTOR, RAS, and MAPK and particularly those affecting the tumor suppressor p53 protein.	Polyphenols	55-66	tumor protein p53	Homo sapiens	233-236
34744708-6	2021	Modifications of p53 induced by these polyphenols regulate p53 gene expression and protein levels and posttranslational modifications such as phosphorylation, acetylation, and ubiquitination that influence stability, subcellular location, activation of new transcriptional targets, and the role of p53 in response to DNA damage, apoptosis control, cell- cycle regulation, senescence, and cell fate.	Polyphenols	38-49	tumor protein p53	Homo sapiens	17-20
34744708-6	2021	Modifications of p53 induced by these polyphenols regulate p53 gene expression and protein levels and posttranslational modifications such as phosphorylation, acetylation, and ubiquitination that influence stability, subcellular location, activation of new transcriptional targets, and the role of p53 in response to DNA damage, apoptosis control, cell- cycle regulation, senescence, and cell fate.	Polyphenols	38-49	tumor protein p53	Homo sapiens	59-62
34600650-7	2021	Early-life grape polyphenols supplementation also promoted the bloom of goblet cells and mucin 2, which benefitted both Akkermansia growth and colonic barrier.	Polyphenols	17-28	mucin 2	Mus musculus	89-96
34600650-8	2021	Moreover, the grape polyphenols-modulated bone morphogenetic protein (BMP), Notch and Wnt3 pathways triggered the bloom of goblet cells in GPs-administrated postweaning mice, and the increase in lactate could modulate those pathways.	Polyphenols	20-31	wingless-type MMTV integration site family, member 3	Mus musculus	86-90
34623753-0	2021	Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification.	Polyphenols	6-16	glutathione peroxidase 4	Mus musculus	116-120
34419542-3	2021	The hydrophobic polyphenol curcumin is shown to inhibit NF-kappaB and hence CR.	Polyphenols	16-26	nuclear factor kappa B subunit 1	Homo sapiens	56-65
34770980-5	2021	Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-kappaB), and c-Jun N-terminal kinases (JNK)).	Polyphenols	0-11	interleukin 1 alpha	Homo sapiens	160-171
34770980-5	2021	Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-kappaB), and c-Jun N-terminal kinases (JNK)).	Polyphenols	0-11	tumor necrosis factor	Homo sapiens	174-195
34770980-5	2021	Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-kappaB), and c-Jun N-terminal kinases (JNK)).	Polyphenols	0-11	tumor necrosis factor	Homo sapiens	197-200
34770980-5	2021	Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-kappaB), and c-Jun N-terminal kinases (JNK)).	Polyphenols	0-11	nuclear factor kappa B subunit 1	Homo sapiens	264-273
34770980-5	2021	Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-kappaB), and c-Jun N-terminal kinases (JNK)).	Polyphenols	0-11	mitogen-activated protein kinase 8	Homo sapiens	280-304
34770980-5	2021	Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-kappaB), and c-Jun N-terminal kinases (JNK)).	Polyphenols	0-11	mitogen-activated protein kinase 8	Homo sapiens	306-309
34768872-0	2021	PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols.	Polyphenols	64-75	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
34768872-6	2021	This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes.	Polyphenols	209-220	poly(ADP-ribose) polymerase 1	Homo sapiens	36-42
34768872-6	2021	This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes.	Polyphenols	209-220	poly(ADP-ribose) polymerase 1	Homo sapiens	240-246
34768872-6	2021	This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes.	Polyphenols	209-220	poly(ADP-ribose) polymerase 1	Homo sapiens	277-281
34768833-0	2021	Polyphenol Metabolite Pyrogallol-O-Sulfate Decreases Microglial Activation and VEGF in Retinal Pigment Epithelium Cells and Diabetic Mouse Retina.	Polyphenols	0-10	vascular endothelial growth factor A	Mus musculus	79-83
34586788-1	2021	Severe acute respiratory syndrome coronavirus (SARS-CoV-2) main protease (Mpro) inhibitors are considered as potential treatments for coronavirus disease 2019, and dietary polyphenols show promise in SARS-CoV-2 Mpro inhibition based on in silico studies.	Polyphenols	172-183	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	211-215
34520942-0	2021	Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of TH1 and TH2 cells.	Polyphenols	0-11	negative elongation factor complex member C/D	Homo sapiens	131-134
34733158-0	2021	Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways.	Polyphenols	27-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	180-184
34733158-0	2021	Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways.	Polyphenols	27-37	heme oxygenase 1	Rattus norvegicus	185-189
34679726-9	2021	In addition, a moderate decrease in SGK1 phosphorylation at Ser422 was observed in polyphenol-treated cells.	Polyphenols	83-93	serum/glucocorticoid regulated kinase 1	Homo sapiens	36-40
34679725-2	2021	Small heterodimer partner-interacting leucine zipper protein (SMILE), a polyphenol-inducible transcriptional co-repressor, regulates hepatic gluconeogenesis and lipogenesis.	Polyphenols	72-82	CREB/ATF bZIP transcription factor	Homo sapiens	0-60
34679725-2	2021	Small heterodimer partner-interacting leucine zipper protein (SMILE), a polyphenol-inducible transcriptional co-repressor, regulates hepatic gluconeogenesis and lipogenesis.	Polyphenols	72-82	CREB/ATF bZIP transcription factor	Homo sapiens	62-67
34650665-6	2021	Dihydromyricetin, as a bioactive polyphenol, has been used for anti-inflammatory, antitumor, and improving insulin sensitivity.	Polyphenols	33-43	insulin	Homo sapiens	107-114
34480268-0	2021	Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases.	Polyphenols	35-46	renin binding protein	Homo sapiens	74-77
34480268-5	2021	To exert their functions, polyphenols target various molecular mechanisms and signaling pathways, such as mTOR, NF-kappaB, and Wnt/beta-catenin.	Polyphenols	26-37	mechanistic target of rapamycin kinase	Homo sapiens	106-110
34480268-5	2021	To exert their functions, polyphenols target various molecular mechanisms and signaling pathways, such as mTOR, NF-kappaB, and Wnt/beta-catenin.	Polyphenols	26-37	catenin beta 1	Homo sapiens	131-143
34480268-9	2021	Herein, we review the studies dealing with the role of polyphenols in targeting the Wnt signaling pathways in aging processes and age-associated diseases, including cancer, diabetes, Alzheimer"s disease, osteoporosis, and Parkinson"s disease.	Polyphenols	55-66	renin binding protein	Homo sapiens	130-133
34534897-8	2021	RESULTS: Compared to the control diet, the PR-diet increased serum metabolites related to polyphenols and methylxanthine intake.	Polyphenols	90-101	transmembrane protein 37	Homo sapiens	43-45
34652225-0	2021	Advance in dietary polyphenols as dipeptidyl peptidase-IV inhibitors to alleviate type 2 diabetes mellitus: aspects from structure-activity relationship and characterization methods.	Polyphenols	19-30	dipeptidyl peptidase 4	Homo sapiens	34-57
34652225-2	2021	Dietary polyphenols have attracted attention as dipeptidyl peptidase-IV (DPP-IV) inhibitors and indirectly improve insulin secretion.	Polyphenols	8-19	dipeptidyl peptidase 4	Homo sapiens	48-71
34652225-2	2021	Dietary polyphenols have attracted attention as dipeptidyl peptidase-IV (DPP-IV) inhibitors and indirectly improve insulin secretion.	Polyphenols	8-19	dipeptidyl peptidase 4	Homo sapiens	73-79
34652225-2	2021	Dietary polyphenols have attracted attention as dipeptidyl peptidase-IV (DPP-IV) inhibitors and indirectly improve insulin secretion.	Polyphenols	8-19	insulin	Homo sapiens	115-122
34652225-3	2021	The DPP-IV inhibitory activities of dietary polyphenols depend on their structural diversity.	Polyphenols	44-55	dipeptidyl peptidase 4	Homo sapiens	4-10
34652225-4	2021	Screening methods that can be used to rapidly and accurately identify potential polyphenol DPP-IV inhibitors are urgently needed.	Polyphenols	80-90	dipeptidyl peptidase 4	Homo sapiens	91-97
34652225-5	2021	This review focuses on the relationship between the structures of dietary polyphenols and their DPP-IV inhibitory effects.	Polyphenols	74-85	dipeptidyl peptidase 4	Homo sapiens	96-102
34652225-6	2021	Different characterization methods used for polyphenols as DPP-IV inhibitors have been summarized and compared.	Polyphenols	44-55	dipeptidyl peptidase 4	Homo sapiens	59-65
34652225-8	2021	Various combinations of methods, such as in-vitro enzymatic inhibition, ex-vivo/in-vivo enzymatic inhibition, cell-based in situ, and in-silico virtual screening, are used to evaluate the DPP-IV inhibitory effects of dietary polyphenols.	Polyphenols	225-236	dipeptidyl peptidase 4	Homo sapiens	188-194
34681584-0	2021	Molecular Mechanism of Food-Derived Polyphenols on PD-L1 Dimerization: A Molecular Dynamics Simulation Study.	Polyphenols	36-47	CD274 molecule	Sus scrofa	51-56
34681584-2	2021	The food-derived polyphenols curcumin (CC), resveratrol (RSV) and epigallocatechin gallate (EGCG) have anticancer immunologic functions, which, recently, have been proposed to act via the downregulation of PD-L1 expression.	Polyphenols	17-28	CD274 molecule	Sus scrofa	206-211
34693047-6	2021	The effects of licorice-derived flavonoid oil-Glavonoid, a natural substance that includes glabridin and several polyphenols-on stabilizing the TTR tetramer must still be elucidated.	Polyphenols	113-124	transthyretin	Homo sapiens	144-147
34520942-4	2021	Accordingly, polyphenols modulate the TH1/TH2 ratio, the secretion of multiple cytokines, the levels of antibodies, and therefore could contribute to recovering the state of health in these diseases.	Polyphenols	13-24	negative elongation factor complex member C/D	Homo sapiens	38-41
34520942-5	2021	In this review, we summarize the current knowledge on the effects of polyphenols in modulating the humoral response in cancer, infectious and allergic diseases and in autoimmunity by affecting the activity of TH1 and TH2 cells.	Polyphenols	69-80	negative elongation factor complex member C/D	Homo sapiens	209-212
34535900-0	2021	Inhibitory properties of polyphenols in Malus "Winter Red" crabapple fruit on alpha-glucosidase and alpha-amylase using improved methods.	Polyphenols	25-36	sucrase-isomaltase	Homo sapiens	78-95
34535900-1	2021	To explore the inhibitory activity of polyphenols on alpha-glucosidase and alpha-amylase, 16 polyphenols were isolated, identified, and quantified in an edible Malus "Winter Red" crabapple fruit.	Polyphenols	38-49	sucrase-isomaltase	Homo sapiens	53-70
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	Polyphenols	60-71	sucrase-isomaltase	Homo sapiens	194-211
34383255-3	2021	The objective of the study was to examine the potential role of chlorogenic acid (CGA), a polyphenol known for anti-inflammatory effect, in the treatment of experimental AP in mice.	Polyphenols	90-100	LIM homeobox protein 2	Mus musculus	170-172
34081254-0	2021	Downregulation of Hyaluronic acid-CD44 signaling pathway in cervical cancer cell by natural polyphenols Plumbagin, Pongapin and Karanjin.	Polyphenols	92-103	CD44 molecule (Indian blood group)	Homo sapiens	34-38
34346156-3	2021	It has been previously shown that polyphenols from wine and grape extracts possess vasodilator activities, due to the increased expression and phosphorylation of the endothelial nitric oxide synthase (eNOS), and consequent vasodilator nitric oxide (NO) production.	Polyphenols	34-45	nitric oxide synthase 3	Homo sapiens	166-199
34346156-3	2021	It has been previously shown that polyphenols from wine and grape extracts possess vasodilator activities, due to the increased expression and phosphorylation of the endothelial nitric oxide synthase (eNOS), and consequent vasodilator nitric oxide (NO) production.	Polyphenols	34-45	nitric oxide synthase 3	Homo sapiens	201-205
34358533-1	2021	Polyphenols are chemopreventive through the induction of nuclear factor erythroid 2 related factor 2 (Nrf2)-mediated proteins and anti-inflammatory pathways.	Polyphenols	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	57-100
34358533-1	2021	Polyphenols are chemopreventive through the induction of nuclear factor erythroid 2 related factor 2 (Nrf2)-mediated proteins and anti-inflammatory pathways.	Polyphenols	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
34661026-0	2021	Green and Efficient Extraction Approach for Polyphenol Recovery from Lotus Seedpods (Receptaculum Nelumbinis): Gas-Assisted Combined with Glycerol.	Polyphenols	44-54	gastrin	Homo sapiens	111-114
34461423-0	2021	Anthocyanin-enriched polyphenols from Hibiscus syriacus L. (Malvaceae) exert anti-osteoporosis effects by inhibiting GSK-3beta and subsequently activating beta-catenin.	Polyphenols	21-32	glycogen synthase kinase 3 alpha b	Danio rerio	117-126
34461423-0	2021	Anthocyanin-enriched polyphenols from Hibiscus syriacus L. (Malvaceae) exert anti-osteoporosis effects by inhibiting GSK-3beta and subsequently activating beta-catenin.	Polyphenols	21-32	catenin (cadherin-associated protein), beta 1	Danio rerio	155-167
34661026-1	2021	In this paper, the gas-assisted combined with glycerol extraction (GAGE) for polyphenol recovery from lotus seedpods (LSPs) was modeled and optimized.	Polyphenols	77-87	gastrin	Homo sapiens	19-22
34569409-3	2021	Among the 44 studied compounds, 37 polyphenols show interaction with the catalytic dyad of the Mpro protease and 18 polyphenols have a higher binding affinity than that of the Mpro protease inhibitor (N3), indicating their high probability of binding at ACE2: SARS-CoV-2 interface.	Polyphenols	35-46	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	95-99
34621313-0	2021	Therapeutic Effects of Polyphenols on the Treatment of Colorectal Cancer by Regulating Wnt beta-Catenin Signaling Pathway.	Polyphenols	23-34	catenin beta 1	Homo sapiens	91-103
34569409-3	2021	Among the 44 studied compounds, 37 polyphenols show interaction with the catalytic dyad of the Mpro protease and 18 polyphenols have a higher binding affinity than that of the Mpro protease inhibitor (N3), indicating their high probability of binding at ACE2: SARS-CoV-2 interface.	Polyphenols	35-46	angiotensin converting enzyme 2	Homo sapiens	254-258
34569409-3	2021	Among the 44 studied compounds, 37 polyphenols show interaction with the catalytic dyad of the Mpro protease and 18 polyphenols have a higher binding affinity than that of the Mpro protease inhibitor (N3), indicating their high probability of binding at ACE2: SARS-CoV-2 interface.	Polyphenols	116-127	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	95-99
34569409-3	2021	Among the 44 studied compounds, 37 polyphenols show interaction with the catalytic dyad of the Mpro protease and 18 polyphenols have a higher binding affinity than that of the Mpro protease inhibitor (N3), indicating their high probability of binding at ACE2: SARS-CoV-2 interface.	Polyphenols	116-127	angiotensin converting enzyme 2	Homo sapiens	254-258
34569409-6	2021	Estimation of total number of intermolecular hydrogen bonds and binding free energy confirmed the stability of these Mpro-polyphenol complexes over Mpro-curcumin complex.	Polyphenols	122-132	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	117-121
34569409-6	2021	Estimation of total number of intermolecular hydrogen bonds and binding free energy confirmed the stability of these Mpro-polyphenol complexes over Mpro-curcumin complex.	Polyphenols	122-132	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	148-152
34569409-7	2021	Based on the greater binding affinity of polyphenols of pomegranate peel towards Mpro as compared to that of curcumin, pomegranate peel may be considered in any herbal medicinal formulation or may be incorporated into daily diets for prevention of COVID-19.Communicated by Ramaswamy H. Sarma.	Polyphenols	41-52	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	81-85
34553653-0	2021	Harnessing polyphenol power by targeting eNOS for vascular diseases.	Polyphenols	11-21	nitric oxide synthase 3	Homo sapiens	41-45
34587932-3	2021	Tea polyphenols may inhibit DNMT activity.	Polyphenols	4-15	DNA methyltransferase 1	Homo sapiens	28-32
34553653-7	2021	This article will focus on in vitro as well as in vivo and clinical studies evidences of the polyphenols with eNOS modulating activity against vascular disease condition while their molecular mechanism will also be discussed.	Polyphenols	93-104	nitric oxide synthase 3	Homo sapiens	110-114
34564516-0	2021	Construction of Loose Positively Charged NF Membrane by Layer-by-Layer Grafting of Polyphenol and Polyethyleneimine on the PES/Fe Substrate for Dye/Salt Separation.	Polyphenols	83-93	pescadillo ribosomal biogenesis factor 1	Homo sapiens	123-126
34574337-4	2021	While GBF and PF have a higher protein content (41-47%), MF has a significant fiber content (19.9%) as well as a higher polyphenol content (474.77 mg GAE/g) and antioxidant capacities.	Polyphenols	120-130	Kruppel like factor 6	Homo sapiens	6-9
34499500-4	2021	The binding between soy proteins and tea polyphenols could significantly impair in vitro gastric digestion of soymilk by decreasing pepsin diffusivity from 91.3 to 70.3 mum2/s and DH from 17.13 to 13.93% with 1.2 mg/g TPE addition.	Polyphenols	41-52	trafficking protein particle complex subunit 1	Homo sapiens	169-173
34229395-2	2021	Compared with zero-valent iron-loaded biochar (C-nZVI-BC) prepared by the traditional chemical liquid phase synthesis method, G-nZVI-BC containing tea polyphenols further improved dispersibility of Fe0 on biochar, prevented nZVI agglomeration on BC, and promoted PNP degradation.	Polyphenols	151-162	purine nucleoside phosphorylase	Homo sapiens	263-266
34572736-10	2021	Finally, we discuss their potential use in combination with chemotherapies, and, using RSV as a model, we propose polyphenols as adjuvants to enhance the efficacy of anti-PD-1/anti-PD-L1 immunotherapies.	Polyphenols	114-125	programmed cell death 1	Homo sapiens	171-175
34572736-10	2021	Finally, we discuss their potential use in combination with chemotherapies, and, using RSV as a model, we propose polyphenols as adjuvants to enhance the efficacy of anti-PD-1/anti-PD-L1 immunotherapies.	Polyphenols	114-125	CD274 molecule	Homo sapiens	181-186
34246969-0	2021	Pomegranate peel extract polyphenols attenuate the SARS-CoV-2 S-glycoprotein binding ability to ACE2 Receptor: In silico and in vitro studies.	Polyphenols	25-36	angiotensin converting enzyme 2	Homo sapiens	96-100
34482478-0	2021	Structure-based identification of galectin-1 selective modulators in dietary food polyphenols: a pharmacoinformatics approach.	Polyphenols	82-93	galectin 1	Homo sapiens	34-44
34482478-5	2021	The extensive computational techniques include potential drug binding site recognition on galectin-1, binding affinity predictions of ~ 500 polyphenols, molecular docking, and dynamic simulations of galectin-1 with selective dietary polyphenol modulators, followed by the estimation of binding free energy for the identification of dietary polyphenol-based galectin-1 modulators.	Polyphenols	233-243	galectin 1	Homo sapiens	199-209
34482478-7	2021	Thereafter, the intermolecular interactions of the polyphenol compounds with galectin-1 were critically explored through the extra-precision docking technique.	Polyphenols	51-61	galectin 1	Homo sapiens	77-87
34482478-9	2021	The docking analyses indicated the high interaction affinity of different amino acids at the CRD region of galectin-1 with the proposed five polyphenols.	Polyphenols	141-152	galectin 1	Homo sapiens	107-117
34482478-11	2021	Also, the conserved residue (His44, Asn46, Arg48, Val59, Asn61, Trp68, Glu71, and Arg73) associations suggest high affinity and selectivity of polyphenols toward galectin-1 protein.	Polyphenols	143-154	galectin 1	Homo sapiens	162-172
34574195-2	2021	Significant differences in bitter acid, oil and polyphenol content were observed for hop samples according to their origin.	Polyphenols	48-58	HOP homeobox	Homo sapiens	85-88
34146850-2	2021	This study investigated the effects of polyphenols from Pterocarpus santalinus hydroalcoholic extract (PSHE) against gamma radiation-induced derangements via the upregulation of Nrf2.	Polyphenols	39-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-182
34126350-0	2021	Olive polyphenols attenuate TNF-alpha-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.	Polyphenols	6-17	tumor necrosis factor	Mus musculus	28-37
34126350-0	2021	Olive polyphenols attenuate TNF-alpha-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.	Polyphenols	6-17	colony stimulating factor 1 (macrophage)	Mus musculus	49-54
34126350-0	2021	Olive polyphenols attenuate TNF-alpha-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.	Polyphenols	6-17	interleukin 6	Mus musculus	59-63
34126350-0	2021	Olive polyphenols attenuate TNF-alpha-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.	Polyphenols	6-17	thymoma viral proto-oncogene 1	Mus musculus	105-108
34126350-0	2021	Olive polyphenols attenuate TNF-alpha-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.	Polyphenols	6-17	mitogen-activated protein kinase 3	Mus musculus	113-116
34126350-0	2021	Olive polyphenols attenuate TNF-alpha-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.	Polyphenols	6-17	cyclin-dependent kinase 20	Mus musculus	117-120
34563040-6	2021	As a result, ERF1-F3 was abundant in total polyphenols and flavonoids contents with diverse active ingredients.	Polyphenols	43-54	eukaryotic translation termination factor 1	Mus musculus	13-17
34329684-4	2021	In this study, we performed virtual screening to target the presumed inhibitor-binding pocket and identified a highly effective TMEM16A inhibitor, Theaflavin (TF: a tea polyphenol in black tea).	Polyphenols	169-179	anoctamin 1, calcium activated chloride channel	Mus musculus	128-135
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Polyphenols	216-226	interleukin 10	Mus musculus	121-126
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Polyphenols	216-226	interleukin 10	Mus musculus	137-142
34803452-5	2021	The binding energy values of these polyphenols to the SARS-CoV-2 spike and ACE-2 protein were calculated separately with a molecular docking study using the AutoDock 4.2.6 program.	Polyphenols	35-46	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	65-70
34803452-5	2021	The binding energy values of these polyphenols to the SARS-CoV-2 spike and ACE-2 protein were calculated separately with a molecular docking study using the AutoDock 4.2.6 program.	Polyphenols	35-46	angiotensin converting enzyme 2	Homo sapiens	75-80
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Polyphenols	6-16	interleukin 10	Mus musculus	121-126
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Polyphenols	216-226	interleukin 2	Mus musculus	143-147
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Polyphenols	6-16	interleukin 10	Mus musculus	137-142
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Polyphenols	6-16	interleukin 2	Mus musculus	143-147
34097996-0	2021	Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo.	Polyphenols	114-124	monoamine oxidase A	Homo sapiens	13-32
34346218-2	2021	Thus, in this study, we aimed to identify polyphenols that inhibited ASBT activity and to elucidate their mechanism.	Polyphenols	42-53	solute carrier family 10 member 2	Homo sapiens	69-73
34346218-4	2021	Of the 39 polyphenols examined, theaflavin (TF)-3-gallate (TF2A) and theaflavin-3"-gallate (TF2B) have been found to significantly reduce TC uptake in Caco-2 cells to 37.4 +- 2.8 and 33.8 +- 4.0%, respectively, of that in the untreated cells.	Polyphenols	10-21	general transcription factor IIB	Homo sapiens	92-96
34572974-0	2021	Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme.	Polyphenols	24-35	insulin	Homo sapiens	39-46
34572974-0	2021	Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme.	Polyphenols	24-35	insulin degrading enzyme	Homo sapiens	66-90
34572974-6	2021	Our results show that the two polyphenols affect the IDE-dependent degradation of insulin in different ways: EGCG inhibits IDE while resveratrol has no effect.	Polyphenols	30-41	insulin degrading enzyme	Homo sapiens	53-56
34572974-6	2021	Our results show that the two polyphenols affect the IDE-dependent degradation of insulin in different ways: EGCG inhibits IDE while resveratrol has no effect.	Polyphenols	30-41	insulin	Homo sapiens	82-89
34572974-6	2021	Our results show that the two polyphenols affect the IDE-dependent degradation of insulin in different ways: EGCG inhibits IDE while resveratrol has no effect.	Polyphenols	30-41	insulin degrading enzyme	Homo sapiens	123-126
34572974-7	2021	These findings suggest that polyphenols provide a path for developing therapeutic strategies that can selectively target IDE substrate specificity.	Polyphenols	28-39	insulin degrading enzyme	Homo sapiens	121-124
34097996-0	2021	Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo.	Polyphenols	114-124	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
34400737-0	2021	Targeting ROS/NF-kappaB sigaling pathway by the seedless black Vitis vinifera polyphenols in CCl4-intoxicated kidney, lung, brain, and spleen in rats.	Polyphenols	78-89	C-C motif chemokine ligand 4	Homo sapiens	93-97
34369228-11	2021	Grape polyphenols reduced fructosamine and methylglyoxal (MGO) concentrations, and increased endogenous secretory RAGE (esRAGE) gene expression but did not affect the serum concentration.	Polyphenols	6-17	advanced glycosylation end-product specific receptor	Homo sapiens	114-118
34338516-0	2021	Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function.	Polyphenols	45-56	aryl hydrocarbon receptor	Homo sapiens	60-85
34338516-3	2021	In this perspective, we discuss how cellular metabolism may alter the net effect of polyphenols on AhR, thus potentially reconciling some of the conflicting observations reported in the literature.	Polyphenols	84-95	aryl hydrocarbon receptor	Homo sapiens	99-102
34157569-3	2021	Prior studies have suggested that amide derivatives of ferulic acid, a natural polyphenol, may combat multiple AD pathologies, though its impact on Abeta aggregation is controversial.	Polyphenols	79-89	amyloid beta precursor protein	Homo sapiens	148-153
34413929-7	2021	The supplement with 0.2 g/L tea polyphenols in the drinking water also had a good effect in alleviating the heat stress damage of the myocardial cells of hens at 38 C. Accordingly, light pathological lesions and downregulation of the myocardial injury-related indicators (LDH, CK, CK-MB, and TNF-alpha) were shown.	Polyphenols	32-43	tumor necrosis factor	Rattus norvegicus	292-301
34361052-0	2021	Polyphenol Containing Sorghum Brans Exhibit an Anti-Cancer Effect in Apc Min/+ Mice Treated with Dextran Sodium Sulfate.	Polyphenols	0-10	APC, WNT signaling pathway regulator	Mus musculus	69-72
34149875-3	2021	The present study revealed that the natural product hydroxytyrosol (HT), which exhibits a polyphenol scaffold, is a potent inhibitor of TrxR1.	Polyphenols	90-100	thioredoxin reductase 1	Homo sapiens	136-141
34149875-6	2021	HT can serve as polyphenol scaffold to develop novel TrxR1 inhibitors for CRC treatment in the future.	Polyphenols	16-26	thioredoxin reductase 1	Homo sapiens	53-58
34361023-6	2021	This versatile polyphenol exerts its anti-aging effects by intervening in various pathologies and multi-signaling systems, including sirtuin type 1, AMP-activated protein kinase, and nuclear factor-kappaB.	Polyphenols	15-25	sirtuin 1	Homo sapiens	133-147
34272733-5	2021	Moreover, CAT treatment inhibited the activities of polyphenol oxidase, peroxidase, and phenylalanine ammonia lyase and reduced phenol accumulation.	Polyphenols	52-62	LOC102577773	Solanum tuberosum	10-13
34361774-2	2021	The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-kappaB and PPAR-gamma receptor.	Polyphenols	9-19	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
34361774-2	2021	The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-kappaB and PPAR-gamma receptor.	Polyphenols	9-19	nuclear factor kappa B subunit 1	Homo sapiens	280-289
34361774-2	2021	The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-kappaB and PPAR-gamma receptor.	Polyphenols	9-19	peroxisome proliferator activated receptor gamma	Homo sapiens	294-304
34361562-5	2021	These properties of the extracted polyphenols in interaction with the main serum proteins in the human metabolism (human serum albumin (HSA), alpha-beta-globulin (alpha-beta G) and fibrinogen (Fgn)), showed that kiwifruit was more reactive than persimmon.	Polyphenols	34-45	albumin	Homo sapiens	121-134
34264653-4	2021	The levels of cis-4-octenedioic acid, 2-amino-heptanoic acid, indoleacrylic acid, and 2-amino-3-methyl-1-butanol in polyphenol treatments were significantly lower compared to those in the control group (P < 0.05), which delayed the formation of micromolecule of acids and alcohols associated with spoilage and inhibited the protein and lipid oxidation and degradation.	Polyphenols	116-126	suppressor of cytokine signaling 6	Homo sapiens	14-19
34360703-4	2021	Much less is known about the 5-lipoxygenase (5-LOX) pathway as a target of dietary (poly)phenols.	Polyphenols	83-96	arachidonate 5-lipoxygenase	Homo sapiens	29-43
34360703-4	2021	Much less is known about the 5-lipoxygenase (5-LOX) pathway as a target of dietary (poly)phenols.	Polyphenols	83-96	arachidonate 5-lipoxygenase	Homo sapiens	45-50
34360703-5	2021	This systematic review aimed to summarize how dietary (poly)phenols target the 5-LOX pathway in preclinical and human studies.	Polyphenols	54-67	arachidonate 5-lipoxygenase	Homo sapiens	79-84
34360703-9	2021	Therefore, increasing the number of studies targeting the 5-LOX pathway would largely expand our knowledge on the anti-inflammatory mechanisms of (poly)phenols.	Polyphenols	146-159	arachidonate 5-lipoxygenase	Homo sapiens	58-63
34361562-5	2021	These properties of the extracted polyphenols in interaction with the main serum proteins in the human metabolism (human serum albumin (HSA), alpha-beta-globulin (alpha-beta G) and fibrinogen (Fgn)), showed that kiwifruit was more reactive than persimmon.	Polyphenols	34-45	fibrinogen beta chain	Homo sapiens	181-191
34356363-5	2021	A total of 42 compounds were identified, including stilbenes, flavonoids, and phenolic acids, and a complex of (epi)catechin with beta-CD was detected, confirming the interaction between polyphenols and cyclodextrin.	Polyphenols	187-198	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	130-137
34299605-0	2021	Polyphenol-Enriched Blueberry Preparation Controls Breast Cancer Stem Cells by Targeting FOXO1 and miR-145.	Polyphenols	0-10	forkhead box O1	Homo sapiens	89-94
34299605-0	2021	Polyphenol-Enriched Blueberry Preparation Controls Breast Cancer Stem Cells by Targeting FOXO1 and miR-145.	Polyphenols	0-10	microRNA 145	Homo sapiens	99-106
34243819-5	2021	Polyphenols in red wine and coffee may stimulate AcAld formation by acting as pro-oxidants in the presence of Heme/Mb/Meat.	Polyphenols	0-11	myoglobin	Homo sapiens	115-117
34269666-11	2021	In this review, the main natural compounds that are derived from alkaloids, flavonoids, terpene, and polyphenols as promising TNF-alpha inhibitors will be discussed.	Polyphenols	101-112	tumor necrosis factor	Homo sapiens	126-135
34299519-0	2021	Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin.	Polyphenols	76-86	curcumin	None	88-96
34371836-7	2021	We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1.	Polyphenols	83-93	RELA proto-oncogene, NF-kB subunit	Homo sapiens	121-125
34359469-5	2021	The interactions between the cereal polyphenols and the intestinal epithelium allow the modulation of intestinal barrier function through antioxidant, anti-inflammatory activity and mucin production thereby improving intestinal health.	Polyphenols	36-47	LOC100508689	Homo sapiens	182-187
34371836-7	2021	We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1.	Polyphenols	83-93	signal transducer and activator of transcription 1	Homo sapiens	133-138
34299400-15	2021	The inhibition of kallikrein and activated FXII represents a unique polyphenol-independent anti-inflammatory mechanism of action for the black tea.	Polyphenols	68-78	kallikrein related peptidase 4	Homo sapiens	18-28
34371836-7	2021	We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1.	Polyphenols	83-93	sirtuin 1	Homo sapiens	148-153
34371836-7	2021	We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1.	Polyphenols	83-93	nuclear factor kappa B subunit 1	Homo sapiens	126-131
34276660-7	2021	Finally, we outline future directions of foodomics techniques to investigate GI protective effects of polyphenols.	Polyphenols	102-113	G protein subunit alpha i1	Homo sapiens	77-79
34276660-8	2021	Foodomics based on the combination of several analytical platforms and data processing for genomics, transcriptomics, proteomics and metabolomics studies, provides abundant data and a more comprehensive understanding of the interactions between polyphenols and the GI tract at the molecular level.	Polyphenols	245-256	G protein subunit alpha i1	Homo sapiens	265-267
34276660-9	2021	This contribution provides a basis for further exploring the protective mechanisms of polyphenols on the GI system.	Polyphenols	86-97	G protein subunit alpha i1	Homo sapiens	105-107
34257824-5	2021	Dietary intake of flavonoids, a C15 group of polyphenols, is known to inhibit cancer progression and assist DNA repair through p53-mediated mechanisms in human cells via their antioxidant activities.	Polyphenols	45-56	tumor protein p53	Homo sapiens	127-130
34257824-7	2021	Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis.	Polyphenols	6-17	tumor protein p53	Homo sapiens	49-52
34257824-7	2021	Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis.	Polyphenols	6-17	tumor protein p53	Homo sapiens	106-109
34257824-7	2021	Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis.	Polyphenols	6-17	tumor protein p53	Homo sapiens	178-181
34200683-10	2021	The LR8-treated grapes had higher titratable acidity, while those in the LR4 treatment had higher  Brix and extractable anthocyanin and polyphenol content.	Polyphenols	136-146	transmembrane protein 176B	Homo sapiens	4-7
34124904-0	2021	Apple Polyphenol Extract Improves High-Fat Diet-Induced Hepatic Steatosis by Regulating Bile Acid Synthesis and Gut Microbiota in C57BL/6 Male Mice.	Polyphenols	6-16	glucosidase beta 2	Mus musculus	88-97
34138966-5	2021	Here, we provide experimental evidence that, among 56 tested polyphenols, including plant extracts, brazilin, theaflavin-3,3"-digallate, and curcumin displayed the highest binding with the receptor-binding domain of spike protein, inhibiting viral attachment to the human angiotensin-converting enzyme 2 receptor, and thus cellular entry of pseudo-typed SARS-CoV-2 virions.	Polyphenols	61-72	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	216-221
34207896-8	2021	These preliminary findings show that dietary polyphenols modulate inflammatory and apoptotic activities in rabbit ovary, regulating cyclooxygenase-2 and BAX expression, thus suggesting a functional involvement of these dietary compounds in mammalian reproduction.	Polyphenols	45-56	prostaglandin-endoperoxide synthase 2	Homo sapiens	132-148
34199888-9	2021	In this regard, certain polyphenols, like the flavonoids mentioned before, have been shown to improve the stability, expression, regeneration and folding of rhodopsin mutants in experimental in vitro studies.	Polyphenols	24-35	rhodopsin	Homo sapiens	157-166
34207896-8	2021	These preliminary findings show that dietary polyphenols modulate inflammatory and apoptotic activities in rabbit ovary, regulating cyclooxygenase-2 and BAX expression, thus suggesting a functional involvement of these dietary compounds in mammalian reproduction.	Polyphenols	45-56	BCL2 associated X, apoptosis regulator	Homo sapiens	153-156
34199888-11	2021	We anticipate that polyphenol compounds can be used to target visual photoreceptor proteins, such as rhodopsin, in a way that has only been recently proposed and that these can be used in novel approaches for the treatment of retinal degenerative diseases like retinitis pigmentosa; however, studies in this field are limited and further research is needed in order to properly characterize the effects of these compounds on retinal degenerative diseases through the proposed mechanisms.	Polyphenols	19-29	rhodopsin	Homo sapiens	101-110
34093575-5	2021	The results show that TCH polyphenols can significantly restore the levels of ALT and AST, and TCH intervention can significantly improve the pathological changes of liver tissue in alcohol-exposed mice.	Polyphenols	26-37	glutamic pyruvic transaminase, soluble	Mus musculus	78-81
34129203-2	2021	Mangiferin (MA), a polyphenol compound, has been reported to activate Nrf2/antioxidant-responsive element (ARE) signaling pathway.	Polyphenols	19-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74
34093189-9	2021	Therefore, the ingestion of dietary supplements, food or beverages containing secondary metabolites e.g., polyphenols or terpenoids may alter the bioavailability, therapeutic efficacy and safety of the drugs that are P-gp substrates.	Polyphenols	106-117	phosphoglycolate phosphatase	Homo sapiens	217-221
34093575-5	2021	The results show that TCH polyphenols can significantly restore the levels of ALT and AST, and TCH intervention can significantly improve the pathological changes of liver tissue in alcohol-exposed mice.	Polyphenols	26-37	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	86-89
34065292-5	2021	Our results show that weak antioxidant activity of ADL and ADM in opposition to their high polyphenol, 83.01 mg and 46.4 mg expressed in gallic acid equivalent (GAE)/g of dry weight (DW), respectively, and flavonoid contents 13.12 mg and 4.25 mg expressed in quercetin equivalent (QE)/g dry weight (DW), respectively.	Polyphenols	91-101	adenylosuccinate lyase	Mus musculus	51-54
34069461-0	2021	Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer.	Polyphenols	0-11	CD274 molecule	Homo sapiens	34-39
34069461-0	2021	Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer.	Polyphenols	0-11	programmed cell death 1	Homo sapiens	40-44
34069461-0	2021	Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer.	Polyphenols	0-11	CD274 molecule	Homo sapiens	73-78
34069461-11	2021	In BC, polyphenols were found to downregulate PD-L1 expression.	Polyphenols	7-18	CD274 molecule	Homo sapiens	46-51
34068281-2	2021	Certain polyphenols bind directly to NRH-quinone oxidoreductase 2 (NQO2) and inhibit its activity.	Polyphenols	8-19	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	37-65
34069133-0	2021	Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-kappaB Dependent and Independent Pathways: Protective Effects of Polyphenols.	Polyphenols	163-174	NADPH oxidase 1	Homo sapiens	86-90
34069133-0	2021	Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-kappaB Dependent and Independent Pathways: Protective Effects of Polyphenols.	Polyphenols	163-174	nuclear factor kappa B subunit 1	Homo sapiens	95-104
34069133-10	2021	These data indicated that polyphenols prevented PM-induced migration and cytokine secretion via blocking the ROS-dependent NF-kappaB signaling pathway in VSMCs.	Polyphenols	26-37	nuclear factor kappa B subunit 1	Homo sapiens	123-132
34068281-2	2021	Certain polyphenols bind directly to NRH-quinone oxidoreductase 2 (NQO2) and inhibit its activity.	Polyphenols	8-19	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	67-71
34068815-0	2021	The Effects of Marine Algal Polyphenols, Phlorotannins, on Skeletal Muscle Growth in C2C12 Muscle Cells via Smad and IGF-1 Signaling Pathways.	Polyphenols	28-39	insulin-like growth factor 1	Mus musculus	117-122
34068636-1	2021	The polyphenols curcumin (CU) and ferulic acid (FA) are able to inhibit the aggregation of amyloid-beta (Abeta) peptide with different strengths.	Polyphenols	4-15	amyloid beta precursor protein	Homo sapiens	91-103
34067427-2	2021	The aim of this analysis was to evaluate the association of the levels of immunoglobulin A (IgA) with the prevention of influenza infections and with the polyphenols contained in Okinawan vegetables.	Polyphenols	154-165	CD79a molecule	Homo sapiens	74-90
34068636-1	2021	The polyphenols curcumin (CU) and ferulic acid (FA) are able to inhibit the aggregation of amyloid-beta (Abeta) peptide with different strengths.	Polyphenols	4-15	amyloid beta precursor protein	Homo sapiens	105-110
34507643-3	2021	The polyphenol-enriched products are mainly from fruits and vegetables, including fruits in whole, juice, puree, jam, and the powder of dried fruits, pomace, and peels.	Polyphenols	4-14	F11 receptor	Homo sapiens	113-116
34632164-5	2021	On the one hand, PPh can be considered as plasticizers for PCL, on the other hand, they can act as coupling agent in composite materials, improving their mechanical performance.	Polyphenols	17-20	PHD finger protein 1	Homo sapiens	59-62
34792007-10	2021	Finally, Moroccan propolis had a potent antioxidant activity which may be due to the richness in polyphenols content (90.91 mg EAG/1 g of extract).	Polyphenols	97-108	potassium voltage-gated channel subfamily H member 1	Rattus norvegicus	127-132
34632164-7	2021	What is important is that the aforementioned properties and kinetics of PPh release can be modulated by the use of various concentrations of PPh, and by the modification of PCL matrix with sol-gel-derived BG particles, capable of binding PPh.	Polyphenols	72-75	PHD finger protein 1	Homo sapiens	173-176
34632164-7	2021	What is important is that the aforementioned properties and kinetics of PPh release can be modulated by the use of various concentrations of PPh, and by the modification of PCL matrix with sol-gel-derived BG particles, capable of binding PPh.	Polyphenols	238-241	PHD finger protein 1	Homo sapiens	173-176
34632164-8	2021	The films containing the lowest concentration of PPh exhibited cytocompatibility, significantly increased alkaline phosphatase activity and the expression of bone extracellular matrix proteins (osteocalcin and osteopontin) in human normal osteoblasts, while they reduced intracellular reactive oxygen species production in macrophages.	Polyphenols	49-52	bone gamma-carboxyglutamate protein	Homo sapiens	194-205
34632164-8	2021	The films containing the lowest concentration of PPh exhibited cytocompatibility, significantly increased alkaline phosphatase activity and the expression of bone extracellular matrix proteins (osteocalcin and osteopontin) in human normal osteoblasts, while they reduced intracellular reactive oxygen species production in macrophages.	Polyphenols	49-52	secreted phosphoprotein 1	Homo sapiens	210-221
35357518-6	2022	The findings of this review confirm that polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins are capable of modulating FOXO1 and associated signaling pathways, and they are potential therapeutic agents for NAFLD and related complications.	Polyphenols	41-52	forkhead box O1	Homo sapiens	132-137
35217462-3	2022	We observed that particle size, zeta-potential, and polyphenol bound equivalents of SPI increased significantly after non-covalent modification with catechin.	Polyphenols	52-62	chromogranin A	Homo sapiens	84-87
35218127-9	2022	Although polyphenols reportedly inhibit the NF-kappaB signaling pathway, phosphorylation of NF-kappaB p65 was observed.	Polyphenols	9-20	nuclear factor kappa B subunit 1	Homo sapiens	44-53
35460827-2	2022	To study the anti-inflammatory influence of jujube peel polyphenols in lipopolysaccharide (LPS) induced RAW 264.7 cells through mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and nuclear erythroid 2-related factor 2 (Nrf2) signaling pathways.	Polyphenols	56-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	169-191
35351574-16	2022	CONCLUSION: These results suggest that DI-HET is effective against NAFLD by activation of the SIRT-1/p-LKB-1/AMPK signaling pathway via polyphenols present in the extract.	Polyphenols	136-147	sirtuin 1	Homo sapiens	94-100
35351574-16	2022	CONCLUSION: These results suggest that DI-HET is effective against NAFLD by activation of the SIRT-1/p-LKB-1/AMPK signaling pathway via polyphenols present in the extract.	Polyphenols	136-147	serine/threonine kinase 11	Homo sapiens	103-108
35351574-16	2022	CONCLUSION: These results suggest that DI-HET is effective against NAFLD by activation of the SIRT-1/p-LKB-1/AMPK signaling pathway via polyphenols present in the extract.	Polyphenols	136-147	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	109-113
35364308-0	2022	Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (Mpro) inhibitors to unveil a hope against COVID-19.	Polyphenols	66-77	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	110-114
35460827-4	2022	Meanwhile, jujube peel polyphenols attenuated the generation of TNF-alpha, IL-1beta, IL-6, NO and PGE2 by inhibiting MAPK and NF-kappaB signaling pathways.	Polyphenols	23-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	126-135
35460827-2	2022	To study the anti-inflammatory influence of jujube peel polyphenols in lipopolysaccharide (LPS) induced RAW 264.7 cells through mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and nuclear erythroid 2-related factor 2 (Nrf2) signaling pathways.	Polyphenols	56-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	193-202
35460827-5	2022	Additionally, jujube peel polyphenol activate Nrf2 from the cytoplasm to the nucleus, regulate antioxidant enzymes and pro-inflammatory cytokines, and reduce oxidative stress and inflammatory responses.	Polyphenols	26-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
35460827-6	2022	Results obtained from this study suggest that jujube peel polyphenols may alleviate oxidative stress and inflammation by inhibiting MAPK and NF-kappaB and activating Nrf2 signaling pathways.	Polyphenols	58-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	141-150
35460827-6	2022	Results obtained from this study suggest that jujube peel polyphenols may alleviate oxidative stress and inflammation by inhibiting MAPK and NF-kappaB and activating Nrf2 signaling pathways.	Polyphenols	58-69	nuclear factor, erythroid derived 2, like 2	Mus musculus	166-170
35460827-2	2022	To study the anti-inflammatory influence of jujube peel polyphenols in lipopolysaccharide (LPS) induced RAW 264.7 cells through mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and nuclear erythroid 2-related factor 2 (Nrf2) signaling pathways.	Polyphenols	56-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	208-244
35460827-2	2022	To study the anti-inflammatory influence of jujube peel polyphenols in lipopolysaccharide (LPS) induced RAW 264.7 cells through mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and nuclear erythroid 2-related factor 2 (Nrf2) signaling pathways.	Polyphenols	56-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	246-250
35608915-4	2022	RESULTS: We ascertained the relationship between the skin colour of "Glera rosa" and the polymorphisms in the Myb-gene transcription factors involved in the polyphenols biosynthesis.	Polyphenols	157-168	MYB proto-oncogene, transcription factor	Homo sapiens	110-113
34998155-0	2022	Improving foam performance using colloidal protein-polyphenol complexes: Lactoferrin and tannic acid.	Polyphenols	51-61	lactotransferrin	Bos taurus	73-84
35412073-2	2022	Among the prominent polyphenols contained in citrus fruits and primarily in grapefruit, the flavonoid naringenin is known to be a blocker of the human ether-a-go-go related gene (hERG) potassium channel.	Polyphenols	20-31	ETS transcription factor ERG	Homo sapiens	179-183
35595310-13	2022	CONCLUSIONS: There is a clinically modest effect of dietary polyphenols intervention in HbA1c, proteinuria, GFR, MDA, and C-reactive protein levels in patients with DN.	Polyphenols	60-71	C-reactive protein	Homo sapiens	122-140
35411358-2	2022	Whereafter, increasingly more efforts have been contributed to finding Nrf2-activators, especially from dietary polyphenols.	Polyphenols	112-123	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
35411358-6	2022	Moreover, most polyphenols work through the phosphorylation of Nrf2.	Polyphenols	15-26	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
35587161-0	2022	Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases.	Polyphenols	8-19	advanced glycosylation end-product specific receptor	Homo sapiens	66-70
35630763-8	2022	Moreover, these polyphenols can manage the inflammation via various mechanisms, in particular the inhibition of the transcriptional factor Nf-kappaB.	Polyphenols	16-27	nuclear factor kappa B subunit 1	Homo sapiens	139-148
35625907-0	2022	Natural Polyphenols, 1,2,3,4,6-O-Pentagalloyglucose and Proanthocyanidins, as Broad-Spectrum Anticoronaviral Inhibitors Targeting Mpro and RdRp of SARS-CoV-2.	Polyphenols	8-19	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	130-134
35625907-0	2022	Natural Polyphenols, 1,2,3,4,6-O-Pentagalloyglucose and Proanthocyanidins, as Broad-Spectrum Anticoronaviral Inhibitors Targeting Mpro and RdRp of SARS-CoV-2.	Polyphenols	8-19	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	139-143
35595186-1	2022	Polyphenols are tremendously effective in eliminating the amyloid-beta aggregations, the main hallmark of Alzheimer"s disease.	Polyphenols	0-11	amyloid beta precursor protein	Homo sapiens	58-70
35421887-0	2022	Effects of red raspberry polyphenols and metabolites on the biomarkers of inflammation and insulin resistance in type 2 diabetes: a pilot study.	Polyphenols	25-36	insulin	Homo sapiens	91-98
35631233-2	2022	SIRT1 activators include polyphenols and vitamins, the antioxidant properties of which are well-known.	Polyphenols	25-36	sirtuin 1	Homo sapiens	0-5
35635447-3	2022	Therefore, it is beneficial for cells to increase their antioxidant defense in response to detrimental insults, either by activating an antioxidant pathway like Keap1/Nrf2 or by improving redox scavengers (vitamins A, C, and E, beta-carotene, and polyphenols, among others).	Polyphenols	247-258	kelch like ECH associated protein 1	Homo sapiens	161-166
35635447-3	2022	Therefore, it is beneficial for cells to increase their antioxidant defense in response to detrimental insults, either by activating an antioxidant pathway like Keap1/Nrf2 or by improving redox scavengers (vitamins A, C, and E, beta-carotene, and polyphenols, among others).	Polyphenols	247-258	NFE2 like bZIP transcription factor 2	Homo sapiens	167-171
35578732-4	2022	Two polyphenols dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) were recently reported as SARS-CoV-2 Mpro inhibitors.	Polyphenols	4-15	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	101-105
35485931-0	2022	The Ameliorating Effects of Apple Polyphenol Extract on High-Fat-Diet-Induced Hepatic Steatosis Are SIRT1-Dependent: Evidence from Hepatic-Specific SIRT1 Heterozygous Mutant C57BL/6 Mice.	Polyphenols	34-44	sirtuin 1	Mus musculus	100-105
35485931-0	2022	The Ameliorating Effects of Apple Polyphenol Extract on High-Fat-Diet-Induced Hepatic Steatosis Are SIRT1-Dependent: Evidence from Hepatic-Specific SIRT1 Heterozygous Mutant C57BL/6 Mice.	Polyphenols	34-44	sirtuin 1	Mus musculus	148-153
35538570-7	2022	Also there was significant negative associations between stilbenes intake and cholesterol (CHOL) level (P-value = 0.03), other polyphenols intake and triglyceride (TG) ((P-value = 0.01), lignan intake and homeostasis model assessment insulin resistance (HOMA-IR) (P-value = 0.03).	Polyphenols	127-138	insulin	Homo sapiens	234-241
35471225-0	2022	Tea polyphenols alleviate the adverse effects of diabetes on oocyte quality.	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
35471225-3	2022	Polyphenols are the most abundant bioactive components of green tea.	Polyphenols	0-11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	64-67
35441186-4	2022	Our results showed that the existence of the galloyl moiety in the structure of polyphenols was necessary for their inhibition of adipogenic differentiation, which could help to delay cells from entering the G2/M phase as well as to hinder the MCE process in the early stage of differentiation and the downstream PPARgamma and C/EBPalpha related MAPK signaling pathway, probably via binding to IR and disturbing the alpha-helix in its conformation.	Polyphenols	80-91	peroxisome proliferator activated receptor gamma	Homo sapiens	313-322
35471225-4	2022	It is reported that tea polyphenols have many health functions, for instance anti-oxidation, anti-inflammation, anti-obesity, and anti-diabetes.	Polyphenols	24-35	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	20-23
35471225-5	2022	Thus, we hypothesize that tea polyphenols may play a crucial role in alleviating adverse effects of diabetes on oocyte quality.	Polyphenols	30-41	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	26-29
35471225-6	2022	In the present study, we researched the effects of tea polyphenols on diabetic oocyte maturation in vitro.	Polyphenols	55-66	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	51-54
35471225-8	2022	However, tea polyphenols significantly increased the oocyte maturation rate, and reduced the incidence of abnormal spindle assembly and chromosome segregation.	Polyphenols	13-24	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	9-12
35471225-9	2022	Tea polyphenols also obviously decreased the reactive oxygen species (ROS) levels in diabetic oocytes, and increased the expression of antioxidant genes (Sod1 and Sod2).	Polyphenols	4-15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
35471225-9	2022	Tea polyphenols also obviously decreased the reactive oxygen species (ROS) levels in diabetic oocytes, and increased the expression of antioxidant genes (Sod1 and Sod2).	Polyphenols	4-15	superoxide dismutase 1, soluble	Mus musculus	154-158
35471225-9	2022	Tea polyphenols also obviously decreased the reactive oxygen species (ROS) levels in diabetic oocytes, and increased the expression of antioxidant genes (Sod1 and Sod2).	Polyphenols	4-15	superoxide dismutase 2, mitochondrial	Mus musculus	163-167
35471225-10	2022	Abnormal mitochondrial membrane potential was also alleviated in diabetic oocytes, and the expression of genes regulating mitochondrial fusion (Opa1, Mfn1 and Mfn2) and fission (Drp1) was significantly increased while tea polyphenols were added.	Polyphenols	222-233	OPA1, mitochondrial dynamin like GTPase	Mus musculus	144-148
35471225-10	2022	Abnormal mitochondrial membrane potential was also alleviated in diabetic oocytes, and the expression of genes regulating mitochondrial fusion (Opa1, Mfn1 and Mfn2) and fission (Drp1) was significantly increased while tea polyphenols were added.	Polyphenols	222-233	mitofusin 1	Mus musculus	150-154
35441186-4	2022	Our results showed that the existence of the galloyl moiety in the structure of polyphenols was necessary for their inhibition of adipogenic differentiation, which could help to delay cells from entering the G2/M phase as well as to hinder the MCE process in the early stage of differentiation and the downstream PPARgamma and C/EBPalpha related MAPK signaling pathway, probably via binding to IR and disturbing the alpha-helix in its conformation.	Polyphenols	80-91	CCAAT enhancer binding protein alpha	Homo sapiens	327-337
35471225-10	2022	Abnormal mitochondrial membrane potential was also alleviated in diabetic oocytes, and the expression of genes regulating mitochondrial fusion (Opa1, Mfn1 and Mfn2) and fission (Drp1) was significantly increased while tea polyphenols were added.	Polyphenols	222-233	collapsin response mediator protein 1	Mus musculus	178-182
35471225-10	2022	Abnormal mitochondrial membrane potential was also alleviated in diabetic oocytes, and the expression of genes regulating mitochondrial fusion (Opa1, Mfn1 and Mfn2) and fission (Drp1) was significantly increased while tea polyphenols were added.	Polyphenols	222-233	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	218-221
35441186-4	2022	Our results showed that the existence of the galloyl moiety in the structure of polyphenols was necessary for their inhibition of adipogenic differentiation, which could help to delay cells from entering the G2/M phase as well as to hinder the MCE process in the early stage of differentiation and the downstream PPARgamma and C/EBPalpha related MAPK signaling pathway, probably via binding to IR and disturbing the alpha-helix in its conformation.	Polyphenols	80-91	insulin receptor	Homo sapiens	394-396
35471225-11	2022	Meanwhile, tea polyphenols reduced DNA damage in diabetic oocytes which may be mediated by the increased expression of Rad51, related to DNA damage repair.	Polyphenols	15-26	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	11-14
35275634-3	2022	In this study, transmission electron microscopy results demonstrate the existence of CDs in herbal tea, while Fourier transform infrared and X-ray photoelectron spectroscopy results suggest the participation of polyphenol in herbal tea CD (H-CD) formation.	Polyphenols	211-221	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	232-235
35471225-11	2022	Meanwhile, tea polyphenols reduced DNA damage in diabetic oocytes which may be mediated by the increased expression of Rad51, related to DNA damage repair.	Polyphenols	15-26	RAD51 recombinase	Mus musculus	119-124
35471225-12	2022	Our results suggest that tea polyphenols would, at least partially, restore the adverse effects of diabetes mellitus on oocyte quality.	Polyphenols	29-40	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	25-28
35527362-12	2022	DG-SDH formulated at a ratio of 3:2 (DG-SDH (3:2)) produced the highest content of polysaccharides, polyphenols, and flavonoids.	Polyphenols	100-111	serine dehydratase	Homo sapiens	3-6
35527362-12	2022	DG-SDH formulated at a ratio of 3:2 (DG-SDH (3:2)) produced the highest content of polysaccharides, polyphenols, and flavonoids.	Polyphenols	100-111	serine dehydratase	Homo sapiens	40-43
35571253-0	2022	The Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer.	Polyphenols	23-34	bone morphogenetic protein receptor type 2	Homo sapiens	10-14
35451223-3	2022	The Ac-beta-CD-DHA based nanoparticles are coated by an iron-containing polyphenol network.	Polyphenols	72-82	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	7-14
35566228-1	2022	It is recognized that minor dietary components polyphenols have anticancer effects on digestive tract, lung, leukemia, and other cancers, while polyphenols also can covalently or noncovalently interact with major dietary components proteins such as casein, soybean proteins, whey proteins, and bovine serum albumin.	Polyphenols	47-58	albumin	Homo sapiens	301-314
35566228-1	2022	It is recognized that minor dietary components polyphenols have anticancer effects on digestive tract, lung, leukemia, and other cancers, while polyphenols also can covalently or noncovalently interact with major dietary components proteins such as casein, soybean proteins, whey proteins, and bovine serum albumin.	Polyphenols	144-155	albumin	Homo sapiens	301-314
35566228-2	2022	Thus, whether the noncovalent interaction between the molecules of two polyphenols (quercetin and fisetin) and two proteins (bovine serum albumin and casein) has positive or negative impact on anticancer activities of the polyphenols against human gastric adenocarcinoma AGS cells was assessed in this study.	Polyphenols	71-82	albumin	Homo sapiens	132-145
35566228-2	2022	Thus, whether the noncovalent interaction between the molecules of two polyphenols (quercetin and fisetin) and two proteins (bovine serum albumin and casein) has positive or negative impact on anticancer activities of the polyphenols against human gastric adenocarcinoma AGS cells was assessed in this study.	Polyphenols	222-233	albumin	Homo sapiens	132-145
35627221-2	2022	In particular, cigarette smoke and tea polyphenols may influence DNMT3B mRNA expression by regulating microRNA (miR)-29b expression.	Polyphenols	39-50	DNA methyltransferase 3 beta	Homo sapiens	65-71
35627221-2	2022	In particular, cigarette smoke and tea polyphenols may influence DNMT3B mRNA expression by regulating microRNA (miR)-29b expression.	Polyphenols	39-50	microRNA 29b-1	Homo sapiens	102-120
35247420-0	2022	Role of polyphenols in combating Type 2 Diabetes and insulin resistance.	Polyphenols	8-19	insulin	Homo sapiens	53-60
35247420-7	2022	Several polyphenols such as resveratrol, epigallocatechin-3-gallate (EGCG) and quercetin enhanced glucose uptake in the muscles and adipocytes by translocating GLUT4 to plasma membrane mainly by the activation of the AMP-activated protein kinase (AMPK) pathway.	Polyphenols	8-19	solute carrier family 2 member 4	Homo sapiens	160-165
35247420-8	2022	This review provides an insight into the protective role of polyphenols in T2D, highlighting the aspects of insulin resistance.	Polyphenols	60-71	insulin	Homo sapiens	108-115
35373729-12	2022	Transcription factors, such as MEF2A, MYB or HNF1A, could have their activity modulated by mate consumption either by direct interaction with polyphenol metabolites or by interactions of metabolites with cell signaling proteins, like p38 or ERK1/2, that could modulate transcription factor activity and regulate expression of genes observed.	Polyphenols	142-152	myocyte enhancer factor 2A	Homo sapiens	31-36
35458686-6	2022	We also explain how polyphenols, which are attracting attention as aggregation inhibitors of Abeta peptides, interact with Abeta.	Polyphenols	20-31	amyloid beta precursor protein	Homo sapiens	93-98
35458686-6	2022	We also explain how polyphenols, which are attracting attention as aggregation inhibitors of Abeta peptides, interact with Abeta.	Polyphenols	20-31	amyloid beta precursor protein	Homo sapiens	123-128
35373729-12	2022	Transcription factors, such as MEF2A, MYB or HNF1A, could have their activity modulated by mate consumption either by direct interaction with polyphenol metabolites or by interactions of metabolites with cell signaling proteins, like p38 or ERK1/2, that could modulate transcription factor activity and regulate expression of genes observed.	Polyphenols	142-152	MYB proto-oncogene, transcription factor	Homo sapiens	38-41
35373729-12	2022	Transcription factors, such as MEF2A, MYB or HNF1A, could have their activity modulated by mate consumption either by direct interaction with polyphenol metabolites or by interactions of metabolites with cell signaling proteins, like p38 or ERK1/2, that could modulate transcription factor activity and regulate expression of genes observed.	Polyphenols	142-152	HNF1 homeobox A	Homo sapiens	45-50
35379147-7	2022	CONCLUSION: Although the specific molecular targets, bioavailability, route of administration, and dosages of some of these natural compounds need to be determined, polyphenols and their combinations represent a very promising and safe strategy to be considered for use against Leishmania spp and Trypanosoma spp.	Polyphenols	165-176	histocompatibility minor 13	Homo sapiens	309-312
35453298-1	2022	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin.	Polyphenols	114-125	aryl hydrocarbon receptor	Homo sapiens	31-34
35419162-10	2022	In addition, we summarized the research advances of phytochemicals, including polyphenols, terpenoids, natural pigments, and otherwise, in the activation of Nrf2 signaling and their potential therapies for TBI.	Polyphenols	78-89	NFE2 like bZIP transcription factor 2	Homo sapiens	157-161
35464168-3	2022	UVA exposure increased the gene expression of IL-1alpha, the mRNA levels of MMP-1, and hence, the levels of MMP-1 protein in HaCaT cells, whereas cells treated with lotus polyphenol (LP) normalized these values to the control.	Polyphenols	171-181	interleukin 1 alpha	Homo sapiens	46-55
35464168-3	2022	UVA exposure increased the gene expression of IL-1alpha, the mRNA levels of MMP-1, and hence, the levels of MMP-1 protein in HaCaT cells, whereas cells treated with lotus polyphenol (LP) normalized these values to the control.	Polyphenols	171-181	matrix metallopeptidase 1	Homo sapiens	76-81
35464168-3	2022	UVA exposure increased the gene expression of IL-1alpha, the mRNA levels of MMP-1, and hence, the levels of MMP-1 protein in HaCaT cells, whereas cells treated with lotus polyphenol (LP) normalized these values to the control.	Polyphenols	171-181	matrix metallopeptidase 1	Homo sapiens	108-113
35202987-8	2022	These results contribute to a better understanding of the polyphenols" immunomodulatory properties, meaning they could induce tolerogenic antigen-presenting cells, which could polarize T cells to a Treg profile and decrease the activity of CD4+ and CD8+ T effector cells.	Polyphenols	58-69	CD4 antigen	Mus musculus	240-243
35180456-7	2022	Altered gravity also reduced the activity of polyphenol oxidase and covalently bound peroxidase.	Polyphenols	45-55	peroxidase N1	Nicotiana tabacum	85-95
35408611-0	2022	Potential Therapeutic Target Protein Tyrosine Phosphatase-1B for Modulation of Insulin Resistance with Polyphenols and Its Quantitative Structure-Activity Relationship.	Polyphenols	103-114	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	29-60
35408611-0	2022	Potential Therapeutic Target Protein Tyrosine Phosphatase-1B for Modulation of Insulin Resistance with Polyphenols and Its Quantitative Structure-Activity Relationship.	Polyphenols	103-114	insulin	Homo sapiens	79-86
35408611-4	2022	This article deals with the screening of a database of polyphenols against PTP1B activity for the identification of a potential inhibitor.	Polyphenols	55-66	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	75-80
35408611-7	2022	The second objective emphasized the binding potential of the selected polyphenols against the activity of PTP1B using molecular docking, molecular dynamic (MD) simulation and free energy estimation.	Polyphenols	70-81	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	106-111
35408611-11	2022	The results demonstrated that the identified polyphenol, silydianin, could act as a promising natural PTP1B inhibitor that can modulate the insulin resistance.	Polyphenols	45-55	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	102-107
35408611-11	2022	The results demonstrated that the identified polyphenol, silydianin, could act as a promising natural PTP1B inhibitor that can modulate the insulin resistance.	Polyphenols	45-55	insulin	Homo sapiens	140-147
35321703-5	2022	polyphenols (ILTPs) on human lung cancer cell line A549 (A549 cells) by regulating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway.	Polyphenols	0-11	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	87-116
35321703-5	2022	polyphenols (ILTPs) on human lung cancer cell line A549 (A549 cells) by regulating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway.	Polyphenols	0-11	protein tyrosine kinase 2 beta	Homo sapiens	117-133
35321703-5	2022	polyphenols (ILTPs) on human lung cancer cell line A549 (A549 cells) by regulating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway.	Polyphenols	0-11	AKT serine/threonine kinase 1	Homo sapiens	140-143
35453301-0	2022	Blueberry Polyphenols Increase Nitric Oxide and Attenuate Angiotensin II-Induced Oxidative Stress and Inflammatory Signaling in Human Aortic Endothelial Cells.	Polyphenols	10-21	angiotensinogen	Homo sapiens	58-72
35138518-0	2022	Tea Polyphenols Attenuates Inflammation via Reducing Lipopolysaccharides Level and Inhibiting TLR4/NF-kappaB Pathway in Obese Mice.	Polyphenols	4-15	toll-like receptor 4	Mus musculus	94-98
35337137-0	2022	New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds.	Polyphenols	35-46	sirtuin 1	Rattus norvegicus	50-59
35255883-7	2022	When the concentration of polyphenols reached 0.1 mg/mL of polyphenols, the scavenging activity of free radical basically reached its maximum, with values of 94.10%, 83.34% and 95.42% for DPPH, ABTS+ and  OH scavenging.	Polyphenols	26-37	thrombopoietin	Mus musculus	53-55
35255883-7	2022	When the concentration of polyphenols reached 0.1 mg/mL of polyphenols, the scavenging activity of free radical basically reached its maximum, with values of 94.10%, 83.34% and 95.42% for DPPH, ABTS+ and  OH scavenging.	Polyphenols	59-70	thrombopoietin	Mus musculus	53-55
35289676-5	2022	Polyphenols can modulate miRNA (miR) expression, with these dietary polyphenols shown to downregulate tumor-promoting miR-21.	Polyphenols	0-11	microRNA 21	Homo sapiens	118-124
35289676-5	2022	Polyphenols can modulate miRNA (miR) expression, with these dietary polyphenols shown to downregulate tumor-promoting miR-21.	Polyphenols	68-79	microRNA 21	Homo sapiens	118-124
35138518-0	2022	Tea Polyphenols Attenuates Inflammation via Reducing Lipopolysaccharides Level and Inhibiting TLR4/NF-kappaB Pathway in Obese Mice.	Polyphenols	4-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
35326124-0	2022	Polyphenol Rich Forsythia suspensa Extract Alleviates DSS-Induced Ulcerative Colitis in Mice through the Nrf2-NLRP3 Pathway.	Polyphenols	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-109
35326124-0	2022	Polyphenol Rich Forsythia suspensa Extract Alleviates DSS-Induced Ulcerative Colitis in Mice through the Nrf2-NLRP3 Pathway.	Polyphenols	0-10	NLR family, pyrin domain containing 3	Mus musculus	110-115
35104489-7	2022	Nutraceuticals belonging to the chemical category polyphenols, alkaloids, terpenoids, flavonoids, tannins have the potential to combat the NF-kappaB pathway.	Polyphenols	50-61	nuclear factor kappa B subunit 1	Homo sapiens	139-148
35250385-6	2022	Polyphenols and flavonoids, secondary metabolites in CCE that regulate the NF-kappaB pathway, may be responsible for its anti-inflammatory activity.	Polyphenols	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
35217709-2	2022	This study investigated how the extraction of polyphenols (which have antioxidant activity) from distillery stillage was affected by solvent type and concentration, extraction time, and method of extraction (conventional solid-liquid extraction, CSLE; ultrasound-assisted extraction, UAE; microwave-assisted extraction, MAE).	Polyphenols	46-57	solute carrier family 6 member 1	Homo sapiens	320-323
35217709-8	2022	With MAE and UAE, polyphenols were recovered more efficiently, with 2.1 times and 1.5 times higher antioxidant activity, and with 15 times and 9 times shorter extraction times, respectively, than with CSLE; thus, they can be considered "green" alternatives to CSLE.	Polyphenols	18-29	solute carrier family 6 member 1	Homo sapiens	5-8
35284456-0	2022	Green Tea Polyphenols Upregulate the Nrf2 Signaling Pathway and Suppress Oxidative Stress and Inflammation Markers in D-Galactose-Induced Liver Aging in Mice.	Polyphenols	10-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	37-41
35133795-0	2022	Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Block Pyroptosis in Endotoxin-Induced Sepsis.	Polyphenols	55-66	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	51-54
35133795-3	2022	Here we reported drug-free tea polyphenols nanoparticles (TPNs) with intrinsic broad-spectrum RONS scavenging and pyroptosis-blocking activities to treat endotoxin (LPS)-induced sepsis in mice.	Polyphenols	31-42	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	27-30
35133795-4	2022	The RONS scavenging activities originated from the polyphenols-derived structure, while the pyroptosis blockage was achieved by inhibiting gasdermin D (GSDMD) mediating the pore formation and membrane rupture, showing multifunctionalities for sepsis therapy.	Polyphenols	51-62	gasdermin D	Mus musculus	139-150
35133795-4	2022	The RONS scavenging activities originated from the polyphenols-derived structure, while the pyroptosis blockage was achieved by inhibiting gasdermin D (GSDMD) mediating the pore formation and membrane rupture, showing multifunctionalities for sepsis therapy.	Polyphenols	51-62	gasdermin D	Mus musculus	152-157
35401920-0	2022	Painful Diabetic Neuropathy Is Associated with Compromised Microglial IGF-1 Signaling Which Can Be Rescued by Green Tea Polyphenol EGCG in Mice.	Polyphenols	120-130	insulin-like growth factor 1	Mus musculus	70-75
35209219-4	2022	Subsequently, a dietary polyphenol, chlorogenic acid, was loaded into the mesopores of MSN (denoted as MSN-His6@CGA), realizing the potential of its anti-inflammatory properties.	Polyphenols	24-34	moesin	Homo sapiens	87-90
35209219-4	2022	Subsequently, a dietary polyphenol, chlorogenic acid, was loaded into the mesopores of MSN (denoted as MSN-His6@CGA), realizing the potential of its anti-inflammatory properties.	Polyphenols	24-34	moesin	Homo sapiens	103-115
35208997-4	2022	The valuable biological properties of chia seeds are related to their rich chemical composition, with particularly high content of polyunsaturated fatty acids, essential amino acids, polyphenols, as well as vitamins and bioelements.	Polyphenols	183-194	chitinase acidic	Homo sapiens	38-42
35267282-4	2022	Physicochemical analysis proved that rose hip pulp and the prepared nectars were valuable sources of polyphenols and ascorbic acid with high antioxidant activity.	Polyphenols	101-112	hedgehog interacting protein	Homo sapiens	42-45
35112849-0	2022	Omics Analyses of Intestinal Microbiota and Hypothalamus Clock Genes in Circadian Disturbance Model Mice Fed with Green Tea Polyphenols.	Polyphenols	124-135	circadian locomotor output cycles kaput	Mus musculus	57-62
35112849-0	2022	Omics Analyses of Intestinal Microbiota and Hypothalamus Clock Genes in Circadian Disturbance Model Mice Fed with Green Tea Polyphenols.	Polyphenols	124-135	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	120-123
35112849-1	2022	Green tea polyphenols (GTP) have similar activities as prebiotics, which effectively regulate the structure of intestinal flora and affect their metabolic pathways.	Polyphenols	10-21	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	6-9
35277012-0	2022	Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease.	Polyphenols	13-24	sirtuin 1	Homo sapiens	36-41
35178129-0	2022	Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP.	Polyphenols	0-10	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	131-136
35178129-8	2022	The activation of which is in a dose- and time-dependent manner, while the activated polyphenol extracts have the effects to stimulate Tat-independent HIV-1 transcription.	Polyphenols	85-95	tyrosine aminotransferase	Homo sapiens	135-138
35178129-9	2022	The mechanism shows that polyphenol extracts from grape seeds and apple can stimulate P-TEFb"s release from 7SK snRNP to induce HIV gene transcription.	Polyphenols	25-35	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	112-117
35164310-1	2022	Twelve polyphenols from three distinct families (dihydroflavonols, flavan-3-ols, and flavanones) were studied as potential substrates of anthocyanidin synthase from Vitis vinifera (VvANS).	Polyphenols	7-18	leucoanthocyanidin dioxygenase	Vitis vinifera	181-186
35277012-3	2022	Nevertheless, in vitro and in vivo studies and clinical trials with humans show that the SIRT1-activating compounds derived from natural sources, such as polyphenols found in fruits, vegetables, and plants, including resveratrol, quercetin, and isoflavones, can prevent disease and be part of treatments for a wide variety of diseases.	Polyphenols	154-165	sirtuin 1	Homo sapiens	89-94
35277012-4	2022	Here, we summarize the roles of SIRT1 and NAD+ metabolism in renal pathophysiology and provide an overview of polyphenols that have the potential to restore SIRT1 and NAD+ metabolism in renal diseases.	Polyphenols	110-121	sirtuin 1	Homo sapiens	157-162
35163520-0	2022	Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-beta1 and NGF-beta Attenuate pKAL-Induced Anticancer Effects via NF-kappaB p65 Upregulation.	Polyphenols	90-101	transforming growth factor beta 1	Homo sapiens	144-153
35063742-3	2022	Polyphenol ellagic acid loaded core-shell PLN (EA-PLN(C/S)) was characterized of favorable physicochemical properties in simulated gastric- and intestinal fluids, including high drug loading capacity, slow drug release and prolonged stability.	Polyphenols	0-10	phospholamban	Mus musculus	42-45
35023169-0	2022	Polyphenols extracted from Shanxi-aged vinegar exert hypolipidemic effects on OA-induced HepG2 cells via the PPARalpha-LXRalpha-ABCA1 pathway.	Polyphenols	0-11	ATP binding cassette subfamily A member 1	Homo sapiens	128-133
35066238-2	2022	The purpose of this study was to investigate whether supplementation of chilled semen extender with green tea polyphenols together with alpha-tocopherol would provide synergistic effects to prolong sperm survival and maintain IZUMO1 protein stability in cat spermatozoa.	Polyphenols	110-121	izumo sperm-egg fusion 1	Homo sapiens	226-232
35066238-8	2022	Sperm IZUMO1 protein was markedly conserved by supplementation of 5 microg/ml alpha-tocopherol together with 0.75 mg/ml green tea polyphenols up to 12 days in cold storage.	Polyphenols	130-141	izumo sperm-egg fusion 1	Homo sapiens	6-12
35066238-9	2022	These findings indicate that green tea polyphenols and alpha-tocopherol have protective effects on the preservation of sperm characteristics and IZUMO1 protein integrity of cat epididymal sperm during long-term chilling.	Polyphenols	39-50	izumo sperm-egg fusion 1	Homo sapiens	145-151
35019268-8	2022	Our thrombin-responsive, polyphenol-based NPs represent a promising platform for advanced drug delivery applications, with potential to improve thrombolytic therapies.	Polyphenols	25-35	coagulation factor II, thrombin	Homo sapiens	4-12
35204100-7	2022	Further, we noted that purified polyphenols and polyphenol-rich substances or extracts exert anti-inflammatory and/or antioxidative effects, which inhibit RANKL/RANK binding via the NF-kappaB pathway, resulting in the suppression of osteoclastogenesis.	Polyphenols	32-43	TNF superfamily member 11	Homo sapiens	155-160
35146014-0	2021	Green Tea Polyphenols Alleviate Hydrogen Peroxide-Induced Oxidative Stress, Inflammation, and Apoptosis in Bovine Mammary Epithelial Cells by Activating ERK1/2-NFE2L2-HMOX1 Pathways.	Polyphenols	10-21	mitogen-activated protein kinase 3	Bos taurus	153-159
35146014-0	2021	Green Tea Polyphenols Alleviate Hydrogen Peroxide-Induced Oxidative Stress, Inflammation, and Apoptosis in Bovine Mammary Epithelial Cells by Activating ERK1/2-NFE2L2-HMOX1 Pathways.	Polyphenols	10-21	NFE2 like bZIP transcription factor 2	Bos taurus	160-166
35146014-0	2021	Green Tea Polyphenols Alleviate Hydrogen Peroxide-Induced Oxidative Stress, Inflammation, and Apoptosis in Bovine Mammary Epithelial Cells by Activating ERK1/2-NFE2L2-HMOX1 Pathways.	Polyphenols	10-21	heme oxygenase 1	Bos taurus	167-172
35204100-7	2022	Further, we noted that purified polyphenols and polyphenol-rich substances or extracts exert anti-inflammatory and/or antioxidative effects, which inhibit RANKL/RANK binding via the NF-kappaB pathway, resulting in the suppression of osteoclastogenesis.	Polyphenols	32-43	nuclear factor kappa B subunit 1	Homo sapiens	182-191
35204100-7	2022	Further, we noted that purified polyphenols and polyphenol-rich substances or extracts exert anti-inflammatory and/or antioxidative effects, which inhibit RANKL/RANK binding via the NF-kappaB pathway, resulting in the suppression of osteoclastogenesis.	Polyphenols	48-58	TNF superfamily member 11	Homo sapiens	155-160
35204100-7	2022	Further, we noted that purified polyphenols and polyphenol-rich substances or extracts exert anti-inflammatory and/or antioxidative effects, which inhibit RANKL/RANK binding via the NF-kappaB pathway, resulting in the suppression of osteoclastogenesis.	Polyphenols	48-58	nuclear factor kappa B subunit 1	Homo sapiens	182-191
35056649-8	2022	All tested polyphenols increased the SOD activity in cells co-incubated with etoposide.	Polyphenols	11-22	superoxide dismutase 1	Homo sapiens	37-40
34975302-0	2022	Mulberry polyphenol extracts attenuated senescence through inhibition of Ras/ERK via promoting Ras degradation in VSMC.	Polyphenols	9-19	mitogen-activated protein kinase 1	Homo sapiens	77-80
34978320-6	2022	Ten preclinical studies have found that prunes and/or their polyphenol extracts decrease malondialdehyde and nitric oxide secretion, increase antioxidant enzyme expression, or suppress NF-kappaB activation and pro-inflammatory cytokine production.	Polyphenols	60-70	nuclear factor kappa B subunit 1	Homo sapiens	185-194
34525916-4	2022	RESULTS: Polyphenols exert beneficial effects in NAFLD, with positive outcomes being related to body weight gain, insulin resistance, liver fat accumulation, oxidative stress, pro-inflammatory status, mitochondrial dysfunction and ER stress.	Polyphenols	9-20	insulin	Homo sapiens	114-121
34525916-5	2022	Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway.	Polyphenols	308-319	peroxisome proliferator activated receptor alpha	Homo sapiens	76-86
34525916-5	2022	Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway.	Polyphenols	308-319	fibroblast growth factor 21	Homo sapiens	87-92
34525916-5	2022	Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway.	Polyphenols	308-319	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	93-97
34525916-5	2022	Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway.	Polyphenols	308-319	PPARG coactivator 1 alpha	Homo sapiens	98-108
34525916-6	2022	Besides, polyphenols downregulate NF-kappaB, suppressing the pro-inflammatory state developed in NAFLD and upregulate liver Nrf2, increasing the cellular antioxidant potential.	Polyphenols	9-20	nuclear factor kappa B subunit 1	Homo sapiens	34-43