PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29740932-7	2018	The LKB1 inhibitor radicicol or knocking down LKB1 prevented autophagy improvement and the M1-to-M2 phenotype shift by T0070907.	monorden	19-28	serine/threonine kinase 11	Mus musculus	4-8
32231947-8	2018	Radicicol counteracted the effect of DON on cytokine secretion, indicating that Hsp90 plays a crucial role in DON-induced cytokine secretion in HL60 cells.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	80-85
29677383-3	2018	Here we report on the effect of the most prominent drug candidates, namely, radicicol, geldanamycin, derivatives of purine, and novobiocin, on Hsp90"s characteristic conformational dynamics and the binding of three interaction partners.	monorden	76-85	heat shock protein 90 alpha family class A member 1	Homo sapiens	143-148
29805488-9	2018	Furthermore, a number of gene-drug interactions, including between HSP90B1 and adenosine-5"-diphosphate and radicicol, were identified.	monorden	108-117	heat shock protein 90 beta family member 1	Homo sapiens	67-74
29660399-3	2018	We have found that H2O2 and radicicol treatment resulted in a significant increase (up to 40%) in the CacyBP/SIP level.	monorden	28-37	calcyclin binding protein	Mus musculus	102-108
29155206-6	2018	CoCl2 (50-100-150muM) was administered for 3 or 6h, alone or combined with Radicicol, that inhibits Cx43 translocation on mitochondria, to demonstrate the crucial role of mitochondrial Cx43 in the cardioprotection.	monorden	75-84	gap junction protein, alpha 1	Rattus norvegicus	100-104
29651431-7	2018	TLR5 mRNA expression was enhanced by both GA and VER155008, whereas cell surface expression of TLR5 was reduced by three different Hsp90 inhibitors, including GA, 17-(allylamino)-17-demethoxygeldanamycin, and radicicol, and an Hsp70 inhibitor.	monorden	209-218	toll like receptor 5	Homo sapiens	95-99
28779264-7	2017	We tested the effect of HSP90 inhibition by three structurally unrelated compounds (alvespimycin, luminespib, radicicol) and asserted its specificity in cells depleted of cytosolic HSP90 (by RNA interference).	monorden	110-119	heat shock protein 90 alpha family class A member 1	Homo sapiens	24-29
28641528-3	2018	Natural products like geldanamycin and radicicol are established Hsp90 inhibitors, but face limitations with toxicity and inactivity, by in vivo studies respectively.	monorden	39-48	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-70
26413502-11	2015	GSK3beta inhibition also reduced myocardial infarct size (41 +- 2%) with HSP90 inhibition by radicicol or DSG partially inhibiting SB216763-induced infarct size reduction (54 +- 3%, 47 +- 1%, resp.).	monorden	93-102	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	73-78
28306192-8	2017	Most significantly, resistant cells were also identified as cross-resistant towards structurally distinct HSP90 inhibitors such as radicicol and the second-generation HSP90 inhibitors CCT018159, VER50589 and AUY922.	monorden	131-140	heat shock protein 90 alpha family class A member 1	Homo sapiens	106-111
27563925-5	2016	HSP90 inhibitors radicicol and 17-DMAG inhibited contractility and reduced the migration of CAF in scratch assays.	monorden	17-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
27563925-5	2016	HSP90 inhibitors radicicol and 17-DMAG inhibited contractility and reduced the migration of CAF in scratch assays.	monorden	17-26	lysine acetyltransferase 2B	Homo sapiens	92-95
27205876-10	2016	Moreover, leptin-induced JAK2/STAT3 phosphorylation was markedly attenuated by the HSP90 inhibitors geldanamycin, radicicol and novobiocin.	monorden	114-123	leptin	Homo sapiens	10-16
27205876-10	2016	Moreover, leptin-induced JAK2/STAT3 phosphorylation was markedly attenuated by the HSP90 inhibitors geldanamycin, radicicol and novobiocin.	monorden	114-123	Janus kinase 2	Homo sapiens	25-29
27205876-10	2016	Moreover, leptin-induced JAK2/STAT3 phosphorylation was markedly attenuated by the HSP90 inhibitors geldanamycin, radicicol and novobiocin.	monorden	114-123	signal transducer and activator of transcription 3	Homo sapiens	30-35
27205876-10	2016	Moreover, leptin-induced JAK2/STAT3 phosphorylation was markedly attenuated by the HSP90 inhibitors geldanamycin, radicicol and novobiocin.	monorden	114-123	heat shock protein 90 alpha family class A member 1	Homo sapiens	83-88
27233944-7	2016	The Hsp90 inhibitor radicicol disrupts the heterocomplex and favors the partial cytoplasmic relocalization of hTERT in similar manner as the overexpression of the TPR-domain peptide of the immunophilin.	monorden	20-29	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
27233944-7	2016	The Hsp90 inhibitor radicicol disrupts the heterocomplex and favors the partial cytoplasmic relocalization of hTERT in similar manner as the overexpression of the TPR-domain peptide of the immunophilin.	monorden	20-29	telomerase reverse transcriptase	Homo sapiens	110-115
27059856-6	2016	Despite being monomeric, the N-terminal region of Smchd1 exhibits ATPase activity, which can be antagonized by the reaction product, ADP, or the Hsp90 inhibitor, radicicol, at a nanomolar concentration.	monorden	162-171	structural maintenance of chromosomes flexible hinge domain containing 1	Homo sapiens	50-56
27059856-6	2016	Despite being monomeric, the N-terminal region of Smchd1 exhibits ATPase activity, which can be antagonized by the reaction product, ADP, or the Hsp90 inhibitor, radicicol, at a nanomolar concentration.	monorden	162-171	heat shock protein 90 alpha family class A member 1	Homo sapiens	145-150
26475763-10	2015	Role of Hsp90 inhibition on signaling pathways was elucidated by using specific chemical inhibitor, radicicol.	monorden	100-109	heat shock protein 90 alpha family class A member 1	Homo sapiens	8-13
25957766-2	2015	Time- and dose dependent induction of HSPA6 (confirmed by qPCR and Western Blots) occurred also upon treatment with Radicicol, another HSP90 inhibitor.	monorden	116-125	heat shock protein family A (Hsp70) member 6	Homo sapiens	38-43
25957766-2	2015	Time- and dose dependent induction of HSPA6 (confirmed by qPCR and Western Blots) occurred also upon treatment with Radicicol, another HSP90 inhibitor.	monorden	116-125	heat shock protein 90 alpha family class A member 1	Homo sapiens	135-140
25680466-2	2015	Here, we identify a small molecule Hsp90 inhibitor radicicol that induces intracellular accumulation of cytotoxic clusterin variant.	monorden	51-60	heat shock protein 90 alpha family class A member 1	Homo sapiens	35-40
28758577-10	2017	We have further on structure-function relationship of HSP90 to understand its efficacy as a new target in AD and PD by utilizing new generation of HSP90 inhibitors such as geldanamycin and its derivatives, 17-AAG, 17-DMAG, IPI-504, radicicol and its derivatives.	monorden	232-241	heat shock protein 90 alpha family class A member 1	Homo sapiens	54-59
24512658-7	2014	Both the K(D) value obtained in saturation experiments with N-ethylcarboxamido-[3H]adenosine at 4 C, at the nanomolar range, and the inhibition constant of its binding by radicicol, the most specific GRP94 inhibitor, indicate that active receptor regions are exposed at the membrane surface.	monorden	171-180	heat shock protein 90 beta family member 1	Homo sapiens	200-205
24970820-4	2014	Little synergy was found between the effects of rapamycin and the Hsp90 inhibitor radicicol on yeast growth.	monorden	82-91	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	66-71
24166465-1	2014	BACKGROUND: We previously reported that radicicol (Hsp90 inhibitor) induced a reduction in the renal blood flow and glomerular filtration rate, in part due to a reduction in urinary NO2/NO3 excretion, suggesting that Hsp90 regulates renal vascular tone in physiological conditions.	monorden	40-49	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	51-56
24166465-1	2014	BACKGROUND: We previously reported that radicicol (Hsp90 inhibitor) induced a reduction in the renal blood flow and glomerular filtration rate, in part due to a reduction in urinary NO2/NO3 excretion, suggesting that Hsp90 regulates renal vascular tone in physiological conditions.	monorden	40-49	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	217-222
25202064-0	2014	Hsp70 inhibition potentiates radicicol-induced cell death in anaplastic thyroid carcinoma cells.	monorden	29-38	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
25202064-1	2014	BACKGROUND/AIM: The aim of the present study was to evaluate the effect of radicicol, an inhibitor of heat shock protein (hsp) 90, alone or in combination with hsp70 inhibition on survival of anaplastic thyroid carcinoma (ATC) cells.	monorden	75-84	heat shock protein 90 alpha family class A member 1	Homo sapiens	102-129
25202064-4	2014	In PIK3CA plasmid-transfected cells, compared to cells treated with radicicol-alone, cell viability increased and cellular death decreased.	monorden	68-77	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	3-9
25202064-5	2014	In cells treated with both radicicol and VER155008, compared to cells treated with radicicol-alone, cell viability further decreased and the percentage of dead cells further increased, with a parallel decrease of the protein levels of heat shock cognate 70, Akt and survivin.	monorden	27-36	AKT serine/threonine kinase 1	Homo sapiens	258-261
25202064-6	2014	CONCLUSION: Our results suggest that radicicol induces cell death mediated through PI3K/Akt signaling with modulation of hsp90 client proteins and hsp70 inhibition enhances radicicol-induced cell death with suppression of survivin in ATC cells.	monorden	37-46	AKT serine/threonine kinase 1	Homo sapiens	88-91
25202064-6	2014	CONCLUSION: Our results suggest that radicicol induces cell death mediated through PI3K/Akt signaling with modulation of hsp90 client proteins and hsp70 inhibition enhances radicicol-induced cell death with suppression of survivin in ATC cells.	monorden	37-46	heat shock protein 90 alpha family class A member 1	Homo sapiens	121-126
25202064-6	2014	CONCLUSION: Our results suggest that radicicol induces cell death mediated through PI3K/Akt signaling with modulation of hsp90 client proteins and hsp70 inhibition enhances radicicol-induced cell death with suppression of survivin in ATC cells.	monorden	37-46	heat shock protein family A (Hsp70) member 4	Homo sapiens	147-152
25202064-6	2014	CONCLUSION: Our results suggest that radicicol induces cell death mediated through PI3K/Akt signaling with modulation of hsp90 client proteins and hsp70 inhibition enhances radicicol-induced cell death with suppression of survivin in ATC cells.	monorden	173-182	AKT serine/threonine kinase 1	Homo sapiens	88-91
25202064-6	2014	CONCLUSION: Our results suggest that radicicol induces cell death mediated through PI3K/Akt signaling with modulation of hsp90 client proteins and hsp70 inhibition enhances radicicol-induced cell death with suppression of survivin in ATC cells.	monorden	173-182	heat shock protein family A (Hsp70) member 4	Homo sapiens	147-152
24435512-0	2014	Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90.	monorden	38-47	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	88-93
23763277-3	2013	We describe a robust and readily assayed proteomics fingerprint that AUY922 shares with the flagship Hsp90 inhibitors 17-DMAG and radicicol.	monorden	130-139	heat shock protein 90 alpha family class A member 1	Homo sapiens	101-106
24007880-5	2013	ADAM28 expression in v-src transformants was partially inhibited by treatment with inhibitors to Src kinase, mitogen-activated protein kinase kinase (MEK), phosphatidylinositol 3-kinase (PI3K), or mammalian target of rapamycin, and abrogated by v-Src kinase inhibitor, radicicol, or a mixture of MEK and PI3K inhibitors.	monorden	269-278	ADAM metallopeptidase domain 28	Homo sapiens	0-6
23946691-1	2013	Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta).	monorden	19-28	nitric oxide synthase 2, inducible	Mus musculus	84-115
23946691-0	2013	Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells.	monorden	0-9	nitric oxide synthase 2, inducible	Mus musculus	19-23
23946691-1	2013	Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta).	monorden	19-28	nitric oxide synthase 2, inducible	Mus musculus	117-121
23946691-1	2013	Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta).	monorden	19-28	tumor necrosis factor	Mus musculus	215-224
23946691-1	2013	Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta).	monorden	19-28	interferon gamma	Mus musculus	226-235
23946691-1	2013	Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta).	monorden	19-28	interleukin 1 beta	Mus musculus	241-249
23946691-2	2013	Treatment of MIN6N8a cells with radicicol inhibited CM-stimulated activation of NF-kappaB/Rel, which plays a critical role in iNOS transcription, in a dose-related manner.	monorden	32-41	nitric oxide synthase 2, inducible	Mus musculus	126-130
23946691-5	2013	Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking ERK1/2 signaling.	monorden	56-65	nitric oxide synthase 2, inducible	Mus musculus	75-79
23946691-5	2013	Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking ERK1/2 signaling.	monorden	56-65	mitogen-activated protein kinase 3	Mus musculus	108-114
23946691-6	2013	Due to the critical role that NO release plays in mediating destruction of pancreatic beta cells, the inhibitory effects of radicicol on iNOS expression suggest that radicicol may represent a useful anti-diabetic activity.	monorden	124-133	nitric oxide synthase 2, inducible	Mus musculus	137-141
23727383-2	2013	As adipocyte differentiation plays a critical role in obesity development, the present study investigated the effect of an Hsp90 inhibitor radicicol on the differentiation of 3T3-L1 preadipocytes and potential mechanisms.	monorden	139-148	heat shock protein 90 alpha family class A member 1	Homo sapiens	123-128
23922935-11	2013	When LKB1 was silenced with siRNA or the inhibitor radicicol, the effect of UA on AMPK activation was diminished.	monorden	51-60	serine/threonine kinase 11	Homo sapiens	5-9
23727383-5	2013	It was found that radicicol dose-dependently decreased intracellular fat accumulation through down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT element binding protein alpha (C/EBPalpha), fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	monorden	18-27	peroxisome proliferator activated receptor gamma	Homo sapiens	128-176
23727383-5	2013	It was found that radicicol dose-dependently decreased intracellular fat accumulation through down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT element binding protein alpha (C/EBPalpha), fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	monorden	18-27	peroxisome proliferator activated receptor gamma	Homo sapiens	178-187
23727383-5	2013	It was found that radicicol dose-dependently decreased intracellular fat accumulation through down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT element binding protein alpha (C/EBPalpha), fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	monorden	18-27	CCAAT enhancer binding protein alpha	Homo sapiens	230-240
23727383-5	2013	It was found that radicicol dose-dependently decreased intracellular fat accumulation through down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT element binding protein alpha (C/EBPalpha), fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	monorden	18-27	fatty acid synthase	Homo sapiens	243-262
23727383-5	2013	It was found that radicicol dose-dependently decreased intracellular fat accumulation through down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT element binding protein alpha (C/EBPalpha), fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	monorden	18-27	fatty acid synthase	Homo sapiens	264-267
23727383-5	2013	It was found that radicicol dose-dependently decreased intracellular fat accumulation through down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT element binding protein alpha (C/EBPalpha), fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	monorden	18-27	fatty acid binding protein 4	Homo sapiens	273-301
23727383-5	2013	It was found that radicicol dose-dependently decreased intracellular fat accumulation through down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT element binding protein alpha (C/EBPalpha), fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	monorden	18-27	fatty acid binding protein 4	Homo sapiens	303-308
23727383-7	2013	Radicicol redcued the phosphorylation of Akt while showing no effect on beta-catenin expression.	monorden	0-9	AKT serine/threonine kinase 1	Homo sapiens	41-44
23727383-8	2013	Radicicol decreased the phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).	monorden	0-9	pyruvate dehydrogenase kinase 1	Homo sapiens	43-78
23727383-8	2013	Radicicol decreased the phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).	monorden	0-9	pyruvate dehydrogenase kinase 1	Homo sapiens	80-84
23727383-9	2013	The results suggest that radicicol inhibited 3T3-L1 preadipocyte differentiation through affecting the PDK1/Akt pathway and subsequent inhibition of mitotic clonal expansion and the expression/activity of adipogenic transcriptional factors and their downstream adipogenic proteins.	monorden	25-34	pyruvate dehydrogenase kinase 1	Homo sapiens	103-107
23727383-9	2013	The results suggest that radicicol inhibited 3T3-L1 preadipocyte differentiation through affecting the PDK1/Akt pathway and subsequent inhibition of mitotic clonal expansion and the expression/activity of adipogenic transcriptional factors and their downstream adipogenic proteins.	monorden	25-34	AKT serine/threonine kinase 1	Homo sapiens	108-111
23496136-0	2013	Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.	monorden	52-61	heat shock protein 90 alpha family class A member 1	Homo sapiens	82-87
23138048-0	2013	Radicicol, an Hsp90 inhibitor, inhibits intestinal inflammation and leakage in abdominal sepsis.	monorden	0-9	heat shock protein, 3	Mus musculus	14-19
23138048-4	2013	MATERIALS AND METHODS: Male C57BL/6 mice were pretreated with radicicol (60 mg/kg), which is a specific inhibitor of Hsp90, prior to cecal ligation and puncture (CLP).	monorden	62-71	heat shock protein, 3	Mus musculus	117-122
23114515-5	2013	The hsp90 inhibitors 17-AAG and radicicol nevertheless caused a dose-dependent reduction in total human tau levels in transgenic larvae without specifically altering tau hyperphosphorylated at S396/S404.	monorden	32-41	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
23107115-5	2013	We established that a single amino acid exchange in the Leishmania Hsp90 renders that protein resistant to the inhibitor radicicol (RAD), yet does not interfere with its functionality.	monorden	121-130	heat shock protein 90 alpha family class A member 1	Homo sapiens	67-72
23344955-5	2013	Accumulation of membrane-bound alpha-synuclein was induced by the expression of a GTPase-deficient Rab3a mutant, by a dominant-negative GDP dissociation inhibitor mutant unable to recycle Rab3a off membranes, and by Hsp90 inhibitors, radicicol and geldanamycin, which are known to inhibit Rab3a dissociation from membranes.	monorden	234-243	synuclein alpha	Homo sapiens	31-46
22920907-3	2013	Previous reports have shown that many oncogenic proteins essential for cancer transformation are chaperoned by the Hsp90 complex, and some of these client proteins have been discovered by using Hsp90 inhibitors, such as geldanamycin (GA) and radicicol (RD).Thus far more than 200 client proteins have been identified.	monorden	242-251	heat shock protein 90 alpha family class A member 1	Homo sapiens	115-120
22920907-3	2013	Previous reports have shown that many oncogenic proteins essential for cancer transformation are chaperoned by the Hsp90 complex, and some of these client proteins have been discovered by using Hsp90 inhibitors, such as geldanamycin (GA) and radicicol (RD).Thus far more than 200 client proteins have been identified.	monorden	242-251	heat shock protein 90 alpha family class A member 1	Homo sapiens	194-199
22865487-5	2012	Radicicol and geldanamycin induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, an increase in Bax levels, the mitochondrial transmembrane potential loss, cytochrome c release, activation of caspases (-8, -9, and -3), cleavage of PARP-1, and an increase in the tumor suppressor p53 levels.	monorden	0-9	BH3 interacting domain death agonist	Homo sapiens	49-52
23350198-2	2012	It was found that nanomolar concentrations of inhibitors of the HSP90 activity (17AAG or radicicol) slowed down chaperone-dependent reactivation of a thermo-labile reporter (luciferase) in heat-stressed HeLa cells and slightly enhanced their death following incubation for 60 min at 43 degrees C. Herein, the inhibitors of HSP90 activity stimulated de novo induction of additional chaperones (HSP70 and HSP27) that significantly increased the intracellular HSP levels.	monorden	89-98	heat shock protein 90 alpha family class A member 1	Homo sapiens	64-69
23350198-2	2012	It was found that nanomolar concentrations of inhibitors of the HSP90 activity (17AAG or radicicol) slowed down chaperone-dependent reactivation of a thermo-labile reporter (luciferase) in heat-stressed HeLa cells and slightly enhanced their death following incubation for 60 min at 43 degrees C. Herein, the inhibitors of HSP90 activity stimulated de novo induction of additional chaperones (HSP70 and HSP27) that significantly increased the intracellular HSP levels.	monorden	89-98	heat shock protein 90 alpha family class A member 1	Homo sapiens	323-328
23350198-2	2012	It was found that nanomolar concentrations of inhibitors of the HSP90 activity (17AAG or radicicol) slowed down chaperone-dependent reactivation of a thermo-labile reporter (luciferase) in heat-stressed HeLa cells and slightly enhanced their death following incubation for 60 min at 43 degrees C. Herein, the inhibitors of HSP90 activity stimulated de novo induction of additional chaperones (HSP70 and HSP27) that significantly increased the intracellular HSP levels.	monorden	89-98	heat shock protein family A (Hsp70) member 4	Homo sapiens	393-398
23350198-2	2012	It was found that nanomolar concentrations of inhibitors of the HSP90 activity (17AAG or radicicol) slowed down chaperone-dependent reactivation of a thermo-labile reporter (luciferase) in heat-stressed HeLa cells and slightly enhanced their death following incubation for 60 min at 43 degrees C. Herein, the inhibitors of HSP90 activity stimulated de novo induction of additional chaperones (HSP70 and HSP27) that significantly increased the intracellular HSP levels.	monorden	89-98	heat shock protein family B (small) member 1	Homo sapiens	403-408
23350198-2	2012	It was found that nanomolar concentrations of inhibitors of the HSP90 activity (17AAG or radicicol) slowed down chaperone-dependent reactivation of a thermo-labile reporter (luciferase) in heat-stressed HeLa cells and slightly enhanced their death following incubation for 60 min at 43 degrees C. Herein, the inhibitors of HSP90 activity stimulated de novo induction of additional chaperones (HSP70 and HSP27) that significantly increased the intracellular HSP levels.	monorden	89-98	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-67
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	monorden	40-49	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	monorden	40-49	heat shock protein 90 alpha family class A member 1	Homo sapiens	236-241
22865487-5	2012	Radicicol and geldanamycin induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, an increase in Bax levels, the mitochondrial transmembrane potential loss, cytochrome c release, activation of caspases (-8, -9, and -3), cleavage of PARP-1, and an increase in the tumor suppressor p53 levels.	monorden	0-9	BCL2 apoptosis regulator	Homo sapiens	54-59
22865487-5	2012	Radicicol and geldanamycin induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, an increase in Bax levels, the mitochondrial transmembrane potential loss, cytochrome c release, activation of caspases (-8, -9, and -3), cleavage of PARP-1, and an increase in the tumor suppressor p53 levels.	monorden	0-9	BCL2 like 1	Homo sapiens	61-67
22865487-5	2012	Radicicol and geldanamycin induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, an increase in Bax levels, the mitochondrial transmembrane potential loss, cytochrome c release, activation of caspases (-8, -9, and -3), cleavage of PARP-1, and an increase in the tumor suppressor p53 levels.	monorden	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
22865487-5	2012	Radicicol and geldanamycin induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, an increase in Bax levels, the mitochondrial transmembrane potential loss, cytochrome c release, activation of caspases (-8, -9, and -3), cleavage of PARP-1, and an increase in the tumor suppressor p53 levels.	monorden	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	247-253
22865487-5	2012	Radicicol and geldanamycin induced a decrease in Bid, Bcl-2, Bcl-xL and survivin protein levels, an increase in Bax levels, the mitochondrial transmembrane potential loss, cytochrome c release, activation of caspases (-8, -9, and -3), cleavage of PARP-1, and an increase in the tumor suppressor p53 levels.	monorden	0-9	tumor protein p53	Homo sapiens	295-298
22851178-9	2012	Platelet P2X1 receptor-, but not P2Y1 receptor-, mediated increases in intracellular calcium were reduced by 40-45% following HSP90 inhibition with geldanamycin or radicicol.	monorden	164-173	purinergic receptor P2X 1	Homo sapiens	9-22
22496241-6	2012	Inhibition of Hsp90 by its specific inhibitors, radicicol or 17-N-allylamino-17-demethoxygeldanamycin, destabilized OGT in primary endothelial cell cultures and enhanced its degradation by the proteasome.	monorden	48-57	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-19
22016308-9	2012	Co-incubation of rings with radicicol and estradiol produced an ER-dependent increase in the relaxation response to SNP of both normal and asthmatic ASM.	monorden	28-37	H19 imprinted maternally expressed transcript	Homo sapiens	149-152
22016308-10	2012	Estrogen-induced relaxation of ASM was abolished by overnight incubation with radicicol and this was associated with reduced expression of ERbeta.	monorden	78-87	H19 imprinted maternally expressed transcript	Homo sapiens	31-34
22016308-10	2012	Estrogen-induced relaxation of ASM was abolished by overnight incubation with radicicol and this was associated with reduced expression of ERbeta.	monorden	78-87	estrogen receptor 2	Homo sapiens	139-145
24280675-2	2012	Hsp90 has been considered as a therapeutic target for cancers and three classes of Hsp90 inhibitors have been developed: (1) benzoquinone ansamycin and its derivatives, (2) radicicol and its derivates, and (3) small synthetic inhibitors.	monorden	173-182	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
24280675-2	2012	Hsp90 has been considered as a therapeutic target for cancers and three classes of Hsp90 inhibitors have been developed: (1) benzoquinone ansamycin and its derivatives, (2) radicicol and its derivates, and (3) small synthetic inhibitors.	monorden	173-182	heat shock protein 90 alpha family class A member 1	Homo sapiens	83-88
22496241-6	2012	Inhibition of Hsp90 by its specific inhibitors, radicicol or 17-N-allylamino-17-demethoxygeldanamycin, destabilized OGT in primary endothelial cell cultures and enhanced its degradation by the proteasome.	monorden	48-57	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	116-119
21368131-5	2011	In contrast, the HSP90 inhibitor radicicol, lacking a bezoquinone moiety, has no measurable effect on cationic current and is less effective in influencing intercellular Ca(2+) concentration.	monorden	33-42	heat shock protein 90 alpha family class A member 1	Homo sapiens	17-22
21465483-7	2012	Moreover, the Hsp90 inhibitor radicicol (RA) prevents accumulation of ubiquitinated caALK5 and phospho-Hsp27 in the cytoskeletal fraction and restore the decreased EC permeability induced by caALK5.	monorden	30-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-19
21465483-7	2012	Moreover, the Hsp90 inhibitor radicicol (RA) prevents accumulation of ubiquitinated caALK5 and phospho-Hsp27 in the cytoskeletal fraction and restore the decreased EC permeability induced by caALK5.	monorden	30-39	heat shock protein family B (small) member 1	Homo sapiens	103-108
21465483-7	2012	Moreover, the Hsp90 inhibitor radicicol (RA) prevents accumulation of ubiquitinated caALK5 and phospho-Hsp27 in the cytoskeletal fraction and restore the decreased EC permeability induced by caALK5.	monorden	41-43	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-19
21465483-7	2012	Moreover, the Hsp90 inhibitor radicicol (RA) prevents accumulation of ubiquitinated caALK5 and phospho-Hsp27 in the cytoskeletal fraction and restore the decreased EC permeability induced by caALK5.	monorden	41-43	heat shock protein family B (small) member 1	Homo sapiens	103-108
21357526-7	2011	The hsp90 inhibitor radicicol or coexpression of an ATPase-defective hsp90 blocked heme insertion into apo-iNOS by 90 and 75%, respectively.	monorden	20-29	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
21357526-7	2011	The hsp90 inhibitor radicicol or coexpression of an ATPase-defective hsp90 blocked heme insertion into apo-iNOS by 90 and 75%, respectively.	monorden	20-29	nitric oxide synthase 2	Homo sapiens	107-111
21439943-3	2011	To verify these observations, we examined whether another Hsp90 inhibitor radicicol (RA) affected P-bodies and stress granules.	monorden	74-83	heat shock protein 90 alpha family class A member 1	Homo sapiens	58-63
22215907-3	2012	Investigators established Hsp90"s druggability using the natural products geldanamycin and radicicol, which mimic the unusual ATP structure adopted in the chaperone"s N-terminal nucleotide-binding pocket and cause potent and selective blockade of ATP binding/hydrolysis, inhibit chaperone function, deplete oncogenic clients, and show antitumor activity.	monorden	91-100	heat shock protein 90 alpha family class A member 1	Homo sapiens	26-31
21800052-0	2012	Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	27-32
21800052-0	2012	Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.	monorden	0-9	TNF superfamily member 10	Homo sapiens	43-48
21800052-5	2012	To assess the ability of an inhibitor of Hsp90 inhibitor radicicol to promote apoptosis, we investigated the effect of radicicol on TRAIL-induced apoptosis in the human epithelial ovarian carcinoma cell lines OVCAR-3 and SK-OV-3.	monorden	119-128	TNF superfamily member 10	Homo sapiens	132-137
21800052-7	2012	Radicicol enhanced TRAIL-induced apoptosis-related protein activation, nuclear damage and cell death.	monorden	0-9	TNF superfamily member 10	Homo sapiens	19-24
21800052-8	2012	These results suggest that radicicol may potentiate the apoptotic effect of TRAIL on ovarian carcinoma cell lines by increasing the activation of the caspase-8- and Bid-dependent pathway and the mitochondria-mediated apoptotic pathway, leading to caspase activation.	monorden	27-36	TNF superfamily member 10	Homo sapiens	76-81
21800052-8	2012	These results suggest that radicicol may potentiate the apoptotic effect of TRAIL on ovarian carcinoma cell lines by increasing the activation of the caspase-8- and Bid-dependent pathway and the mitochondria-mediated apoptotic pathway, leading to caspase activation.	monorden	27-36	caspase 8	Homo sapiens	150-168
21800052-9	2012	Radicicol may confer a benefit in the TRAIL treatment of epithelial ovarian adenocarcinoma.	monorden	0-9	TNF superfamily member 10	Homo sapiens	38-43
21932796-2	2011	A series of resorcylic acid macrolactams, nitrogen analogues of the naturally occurring macrolactone radicicol, have been prepared by chemical synthesis and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents.	monorden	101-110	heat shock protein 90 alpha family class A member 1	Homo sapiens	184-205
21932796-2	2011	A series of resorcylic acid macrolactams, nitrogen analogues of the naturally occurring macrolactone radicicol, have been prepared by chemical synthesis and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents.	monorden	101-110	heat shock protein 90 alpha family class A member 1	Homo sapiens	207-212
21430289-7	2011	Radicicol, another Hsp90 inhibitor whose structure is different from that of geldanamycin, also blocked iNOS mRNA transcription.	monorden	0-9	heat shock protein, 3	Mus musculus	19-24
21430289-7	2011	Radicicol, another Hsp90 inhibitor whose structure is different from that of geldanamycin, also blocked iNOS mRNA transcription.	monorden	0-9	nitric oxide synthase 2, inducible	Mus musculus	104-108
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	monorden	179-188	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	74-78
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	monorden	179-188	serine/threonine kinase 11	Rattus norvegicus	102-106
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	monorden	179-188	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	130-134
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	monorden	179-188	serine/threonine kinase 11	Rattus norvegicus	193-197
21145921-4	2011	Treatment with three distinct HSP90 inhibitors, radicicol, macbecin and 17-DMAG significantly enhanced alpha(2C)-AR cell surface levels at 37 C, but these inhibitors had no effect at 30 C. Similar results were obtained after decreasing the HSP90 cellular levels using specific siRNA.	monorden	48-57	adrenoceptor alpha 2C	Homo sapiens	103-115
21145921-4	2011	Treatment with three distinct HSP90 inhibitors, radicicol, macbecin and 17-DMAG significantly enhanced alpha(2C)-AR cell surface levels at 37 C, but these inhibitors had no effect at 30 C. Similar results were obtained after decreasing the HSP90 cellular levels using specific siRNA.	monorden	48-57	heat shock protein 90 alpha family class A member 1	Homo sapiens	240-245
20961859-1	2010	Resorcylic acid lactones are fungal polyketides that display diverse biological activities, with the potent Hsp90 inhibitor radicicol being an important representative member.	monorden	124-133	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	108-113
21850170-6	2011	STI1 (K434R) and the homologous yeast variant K470R were able to rescue yeast growth-inhibition by the HSP90-inhibitor radicicol.	monorden	119-128	Hsp90 cochaperone STI1	Saccharomyces cerevisiae S288C	0-4
20943306-0	2010	Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms.	monorden	18-27	heat shock protein 90 alpha family class A member 1	Homo sapiens	45-56
20943306-1	2010	Radicicol is a natural antibiotic that specifically inhibits chaperone Hsp90 activity and binds to its active site with nanomolar affinity.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	71-76
20943306-3	2010	Here we present a detailed thermodynamic description of radicicol binding to human Hsp90 and yeast Hsc82 studied by isothermal titration calorimetry and thermal shift assay.	monorden	56-65	heat shock protein 90 alpha family class A member 1	Homo sapiens	83-88
20943306-3	2010	Here we present a detailed thermodynamic description of radicicol binding to human Hsp90 and yeast Hsc82 studied by isothermal titration calorimetry and thermal shift assay.	monorden	56-65	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	99-104
20943306-8	2010	The intrinsic enthalpy of radicicol binding to Hsc82 was -46.7 kJ/mol, to Hsp90alpha -70.7 kJ/mol, and to Hsp90beta was -66.8 kJ/mol.	monorden	26-35	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	47-52
20943306-8	2010	The intrinsic enthalpy of radicicol binding to Hsc82 was -46.7 kJ/mol, to Hsp90alpha -70.7 kJ/mol, and to Hsp90beta was -66.8 kJ/mol.	monorden	26-35	heat shock protein 90 alpha family class A member 1	Homo sapiens	74-84
20943306-8	2010	The intrinsic enthalpy of radicicol binding to Hsc82 was -46.7 kJ/mol, to Hsp90alpha -70.7 kJ/mol, and to Hsp90beta was -66.8 kJ/mol.	monorden	26-35	heat shock protein 90 alpha family class B member 1	Homo sapiens	106-115
20841485-4	2010	Both LATS1 and LATS2 were depleted from cells treated with the HSP90 inhibitors 17-allylamino-17-demethoxygeldanamycin (17-AAG), radicicol, and PU-H71.	monorden	129-138	large tumor suppressor kinase 1	Homo sapiens	5-10
20841485-4	2010	Both LATS1 and LATS2 were depleted from cells treated with the HSP90 inhibitors 17-allylamino-17-demethoxygeldanamycin (17-AAG), radicicol, and PU-H71.	monorden	129-138	large tumor suppressor kinase 2	Homo sapiens	15-20
20534344-3	2010	Unique proteome patterns were observed in HeLa cells treated with the HSP90 inhibitor geldanamycin, and were similar to the patterns induced by radicicol, a structurally different HSP90 inhibitor.	monorden	144-153	heat shock protein 90 alpha family class A member 1	Homo sapiens	70-75
20675372-7	2010	Inhibition of Hsp90 chaperone function by either geldanamycin or radicicol resulted in a decrease in LIS1 levels.	monorden	65-74	platelet activating factor acetylhydrolase 1b regulatory subunit 1	Homo sapiens	101-105
20661961-1	2010	A series of resorcylic acid macrolactones, analogues of the natural product radicicol has been prepared by chemical synthesis, and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents.	monorden	76-85	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	158-179
20661961-1	2010	A series of resorcylic acid macrolactones, analogues of the natural product radicicol has been prepared by chemical synthesis, and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents.	monorden	76-85	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	181-186
20661961-4	2010	Co-crystallization of one of the new macrolactones with the N-terminal domain of yeast Hsp90 confirms that it binds in a similar way to the natural product radicicol and to our previous synthetic analogues, but that the introduction of the additional hydroxymethyl substituent appears to result in an unexpected change in conformation of the macrocyclic ring.	monorden	156-165	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	87-92
20122975-13	2010	Application of geldanamycin, radicicol, quercetin or KNK 437 in combination with aldosterone blocks development of tubules by disturbing the contact between MR and heat shock proteins 90 and 70.	monorden	29-38	nuclear receptor subfamily 3 group C member 2	Homo sapiens	157-159
19948165-6	2010	Radicicol and 17-allylamino-17-demethoxygeldanamycin (17-AAG) at non-cytotoxic doses targeted cell-surface HSP90 in OPCs.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	107-112
19948165-7	2010	Thus, 0.01 nM 17-AAG or 10 nM radicicol competed with the anti-HSP90 antibodies for binding to cell-surface HSP90.	monorden	30-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-68
19948165-7	2010	Thus, 0.01 nM 17-AAG or 10 nM radicicol competed with the anti-HSP90 antibodies for binding to cell-surface HSP90.	monorden	30-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	108-113
19948165-10	2010	The present results show that, despite OPCs being very sensitive to HSP90 inhibitors, low and non-cytotoxic doses of 17-AAG and radicicol protect oligodendrocytes from anti-HSP90 antibody attack.	monorden	128-137	heat shock protein 90 alpha family class A member 1	Homo sapiens	173-178
20479121-4	2010	Hsp104"s tetratricopeptide repeat (TPR) interaction motif was dispensable for curing; however, cells expressing Sti1 defective in Hsp70 or Hsp90 interaction cured less efficiently, and the Hsp90 inhibitor radicicol abolished curing, implying that Sti1 acts in curing through Hsp70 and Hsp90 interactions.	monorden	205-214	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	189-194
20479121-4	2010	Hsp104"s tetratricopeptide repeat (TPR) interaction motif was dispensable for curing; however, cells expressing Sti1 defective in Hsp70 or Hsp90 interaction cured less efficiently, and the Hsp90 inhibitor radicicol abolished curing, implying that Sti1 acts in curing through Hsp70 and Hsp90 interactions.	monorden	205-214	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	189-194
20519952-2	2010	It is possible to selectively inhibit Hsp90 using natural products such as geldanamycin (GA) or radicicol (RD), which have served as prototypes for development of synthetic Hsp90 inhibitors.	monorden	96-105	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	38-43
20519952-2	2010	It is possible to selectively inhibit Hsp90 using natural products such as geldanamycin (GA) or radicicol (RD), which have served as prototypes for development of synthetic Hsp90 inhibitors.	monorden	96-105	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	173-178
20552022-5	2010	METHODOLOGY/PRINCIPAL FINDINGS: In MTT assays, small cell lung cancer cells showed a biphasic response to the Hsp90 inhibitors geldanamycin and radicicol, with low concentrations causing proliferation arrest and high concentrations causing cell death.	monorden	144-153	heat shock protein 90 alpha family class A member 1	Homo sapiens	110-115
20138026-8	2010	We have used this strain to demonstrate that significant levels of resistance to the Hsp90 inhibitors radicicol and 17-allylamino-demethoxygeldanamycin (17-AAG) are generated as a result of the same single point mutation within the native Hsp90 of yeast (A107N), the human Hsp90alpha (A121N) and the human Hsp90beta (A116N).	monorden	102-111	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	85-90
20138026-8	2010	We have used this strain to demonstrate that significant levels of resistance to the Hsp90 inhibitors radicicol and 17-allylamino-demethoxygeldanamycin (17-AAG) are generated as a result of the same single point mutation within the native Hsp90 of yeast (A107N), the human Hsp90alpha (A121N) and the human Hsp90beta (A116N).	monorden	102-111	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	239-244
20138026-8	2010	We have used this strain to demonstrate that significant levels of resistance to the Hsp90 inhibitors radicicol and 17-allylamino-demethoxygeldanamycin (17-AAG) are generated as a result of the same single point mutation within the native Hsp90 of yeast (A107N), the human Hsp90alpha (A121N) and the human Hsp90beta (A116N).	monorden	102-111	heat shock protein 90 alpha family class A member 1	Homo sapiens	273-283
20138026-8	2010	We have used this strain to demonstrate that significant levels of resistance to the Hsp90 inhibitors radicicol and 17-allylamino-demethoxygeldanamycin (17-AAG) are generated as a result of the same single point mutation within the native Hsp90 of yeast (A107N), the human Hsp90alpha (A121N) and the human Hsp90beta (A116N).	monorden	102-111	heat shock protein 90 alpha family class B member 1	Homo sapiens	306-315
20534344-3	2010	Unique proteome patterns were observed in HeLa cells treated with the HSP90 inhibitor geldanamycin, and were similar to the patterns induced by radicicol, a structurally different HSP90 inhibitor.	monorden	144-153	heat shock protein 90 alpha family class A member 1	Homo sapiens	180-185
20237203-10	2010	Radicicol and geldanamycin probably exerted their actions through interactions with Hsc82.	monorden	0-9	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	84-89
19962400-4	2010	Radicicol, a direct inhibitor of heat shock protein 90 (Hsp90) and an indirect inhibitor of steroid hormone receptor signaling, was used to determine the functional utility of this yeast reporter system.	monorden	0-9	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	33-54
19962400-4	2010	Radicicol, a direct inhibitor of heat shock protein 90 (Hsp90) and an indirect inhibitor of steroid hormone receptor signaling, was used to determine the functional utility of this yeast reporter system.	monorden	0-9	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	56-61
19408974-11	2010	Similar effects were observed when cells were treated with radicicol, another hsp90 inhibitor.	monorden	59-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	78-83
20093793-2	2010	Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein.	monorden	0-9	heat shock protein 86, pseudogene 1	Mus musculus	13-18
20093793-2	2010	Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein.	monorden	0-9	heat shock protein 1B	Mus musculus	76-81
20093793-4	2010	Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein.	monorden	23-32	heat shock protein 1B	Mus musculus	82-87
20093793-5	2010	Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol.	monorden	18-27	heat shock protein 1B	Mus musculus	60-65
20093793-5	2010	Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol.	monorden	117-126	heat shock protein 1B	Mus musculus	60-65
20093793-6	2010	Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury.	monorden	69-78	heat shock protein 1B	Mus musculus	52-57
19920922-11	2009	For instance, one cluster gathers three types of proteins (HSP90, topoisomerase VI, and BCK) which all bind the drug radicicol.	monorden	117-126	heat shock protein 90 alpha family class A member 1	Homo sapiens	59-64
19920922-11	2009	For instance, one cluster gathers three types of proteins (HSP90, topoisomerase VI, and BCK) which all bind the drug radicicol.	monorden	117-126	creatine kinase B	Homo sapiens	88-91
19492825-1	2009	Previously, we reported the Hsp90 inhibitory activity of radamide, an open chain amide chimera of geldanamycin and radicicol.	monorden	115-124	heat shock protein 90 alpha family class A member 1	Homo sapiens	28-33
19748980-3	2009	In this study, we tested the effect of 17-allylaminogeldanamycin and radicicol, drugs targeting the heat shock protein-90 (HSP-90) chaperone protein and displaying antimyeloma activity, on the expression of NKG2D and DNAM-1 ligands in human myeloma cell lines.	monorden	69-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	100-121
19748980-3	2009	In this study, we tested the effect of 17-allylaminogeldanamycin and radicicol, drugs targeting the heat shock protein-90 (HSP-90) chaperone protein and displaying antimyeloma activity, on the expression of NKG2D and DNAM-1 ligands in human myeloma cell lines.	monorden	69-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	123-129
19748980-3	2009	In this study, we tested the effect of 17-allylaminogeldanamycin and radicicol, drugs targeting the heat shock protein-90 (HSP-90) chaperone protein and displaying antimyeloma activity, on the expression of NKG2D and DNAM-1 ligands in human myeloma cell lines.	monorden	69-78	killer cell lectin like receptor K1	Homo sapiens	207-212
19754360-7	2009	Several direct inhibitors of HSP90 have been developed, and they are classified into four groups: benzoquinon ansamycines and their derivatives, radicicol and its derivates, small synthetic inhibitors and a final group of other inhibitors.	monorden	145-154	heat shock protein 90 alpha family class A member 1	Homo sapiens	29-34
19856365-1	2009	The pochoximes, based on the radicicol pharmacophore, are potent inhibitors of heat shock protein 90 (HSP90) that retain their activity in vivo.	monorden	29-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	79-100
19856365-1	2009	The pochoximes, based on the radicicol pharmacophore, are potent inhibitors of heat shock protein 90 (HSP90) that retain their activity in vivo.	monorden	29-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	102-107
19856365-4	2009	Cocrystal structures of pochoximes A and B with HSP90 show that pochoximes bind to a different conformation of HSP90 than radicicol and provide a rationale for the enhanced affinity of the pochoximes relative to radicicol and the pochonins.	monorden	122-131	heat shock protein 90 alpha family class A member 1	Homo sapiens	48-53
19856365-4	2009	Cocrystal structures of pochoximes A and B with HSP90 show that pochoximes bind to a different conformation of HSP90 than radicicol and provide a rationale for the enhanced affinity of the pochoximes relative to radicicol and the pochonins.	monorden	212-221	heat shock protein 90 alpha family class A member 1	Homo sapiens	48-53
19856365-4	2009	Cocrystal structures of pochoximes A and B with HSP90 show that pochoximes bind to a different conformation of HSP90 than radicicol and provide a rationale for the enhanced affinity of the pochoximes relative to radicicol and the pochonins.	monorden	212-221	heat shock protein 90 alpha family class A member 1	Homo sapiens	111-116
19482409-0	2009	The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts.	monorden	28-37	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	4-9
19482409-1	2009	We determine the binding mode of a macrocyclic radicicol-like oxime to yeast HSP90 by combining computer simulations and experimental measurements.	monorden	47-56	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	77-82
19482409-6	2009	We find that the most likely binding mode of the oxime to yeast HSP90 is very similar to the known structure of the radicicol-HSP90 complex.	monorden	116-125	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	64-69
19482409-6	2009	We find that the most likely binding mode of the oxime to yeast HSP90 is very similar to the known structure of the radicicol-HSP90 complex.	monorden	116-125	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	126-131
19410458-1	2009	Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores.	monorden	79-88	heat shock protein 90 alpha family class A member 1	Homo sapiens	36-57
19410458-1	2009	Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores.	monorden	79-88	heat shock protein 90 alpha family class A member 1	Homo sapiens	59-64
19447629-0	2009	Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.	monorden	50-59	Wnt family member 5A	Homo sapiens	76-82
19494268-4	2009	Inactivation of HSP90 function using geldanamycin or radicicol inhibited MHC class II presentation of exogenous and endogenous GAD, but did not perturb the presentation of several other intra- and extracellular Ags.	monorden	53-62	heat shock protein 90 alpha family class A member 1	Homo sapiens	16-21
19494268-4	2009	Inactivation of HSP90 function using geldanamycin or radicicol inhibited MHC class II presentation of exogenous and endogenous GAD, but did not perturb the presentation of several other intra- and extracellular Ags.	monorden	53-62	glutamate decarboxylase 1	Homo sapiens	127-130
19236053-2	2009	Highly selective Hsp90 inhibitors, including the natural antibiotics geldanamycin (GdA) and radicicol (RAD), inactivate this essential molecular chaperone by occupying its nucleotide binding site.	monorden	92-101	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	17-22
19293389-4	2009	17Beta-estradiol produced a concentration-dependent relaxation of endothelium-denuded porcine coronary arteries in vitro, and this response was attenuated by inhibiting Hsp90 function with 1 microM geldanamycin (GA) or 100 microg/ml radicicol (RAD).	monorden	233-242	heat shock protein 90 alpha family class A member 1	Homo sapiens	169-174
19293389-4	2009	17Beta-estradiol produced a concentration-dependent relaxation of endothelium-denuded porcine coronary arteries in vitro, and this response was attenuated by inhibiting Hsp90 function with 1 microM geldanamycin (GA) or 100 microg/ml radicicol (RAD).	monorden	244-247	heat shock protein 90 alpha family class A member 1	Homo sapiens	169-174
19320098-8	2009	Upon exposure of the set of Hsp90 test strains to the two Hsp90 inhibitors radicicol (Rd) and geldanamycin (GA), we found that the strain with Pf Hsp90 is relatively more sensitive to GA than to Rd compared to the strains with human Hsp90"s.	monorden	75-84	heat shock protein 90 alpha family class A member 1	Homo sapiens	28-33
19162015-5	2009	Geldanamycin, 17-AAG and another chemically unrelated HSP90 inhibitor, radicicol, were extremely cytotoxic for OPCs.	monorden	71-80	heat shock protein 90 alpha family class A member 1	Homo sapiens	54-59
19320098-8	2009	Upon exposure of the set of Hsp90 test strains to the two Hsp90 inhibitors radicicol (Rd) and geldanamycin (GA), we found that the strain with Pf Hsp90 is relatively more sensitive to GA than to Rd compared to the strains with human Hsp90"s.	monorden	75-84	heat shock protein 90 alpha family class A member 1	Homo sapiens	58-63
19320098-8	2009	Upon exposure of the set of Hsp90 test strains to the two Hsp90 inhibitors radicicol (Rd) and geldanamycin (GA), we found that the strain with Pf Hsp90 is relatively more sensitive to GA than to Rd compared to the strains with human Hsp90"s.	monorden	75-84	heat shock protein 90 alpha family class A member 1	Homo sapiens	58-63
19320098-8	2009	Upon exposure of the set of Hsp90 test strains to the two Hsp90 inhibitors radicicol (Rd) and geldanamycin (GA), we found that the strain with Pf Hsp90 is relatively more sensitive to GA than to Rd compared to the strains with human Hsp90"s.	monorden	75-84	heat shock protein 90 alpha family class A member 1	Homo sapiens	58-63
18726712-6	2009	The proliferation of NPCs induced by hypoxia was inhibited after GA treatment for 24 h. Another HSP90 inhibitor, radicicol, had the same effect on NPCs as GA.	monorden	113-122	heat shock protein 90 alpha family class A member 1	Homo sapiens	96-101
19136580-7	2009	Hsp90 antagonism with radicicol induced greatest constriction in PRA from 12-day-old piglets.	monorden	22-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
19582223-0	2009	Measurement of nanomolar dissociation constants by titration calorimetry and thermal shift assay - radicicol binding to Hsp90 and ethoxzolamide binding to CAII.	monorden	99-108	heat shock protein 90 alpha family class A member 1	Homo sapiens	120-125
18573269-8	2008	Additionally, radicicol significantly increased the number of NCAM-positive satellite cells in the gastrocnemius at one day post-CTX injury.	monorden	14-23	neuronal cell adhesion molecule	Mus musculus	62-66
19103144-7	2009	Second, specific protection from exogenous protease of FKBP12 by FK506 and Hsp90 fragments by radicicol were observed.	monorden	94-103	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	55-61
18945937-8	2009	Inhibition of Hsp-90 with geldanamycin (2 microM) or Radicicol (20 microM) mitigated (0.45 +/- 0.04-fold and 0.93 +/- 0.16-fold, respectively) HG induced-IKKbeta activity (2.5 +/- 0.42-fold).	monorden	53-62	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	154-161
18992226-5	2008	These effects were all reversed by pretreatment with AMPK inhibitor Compound C or LKB1 destabilizer radicicol.	monorden	100-109	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	53-57
18992226-5	2008	These effects were all reversed by pretreatment with AMPK inhibitor Compound C or LKB1 destabilizer radicicol.	monorden	100-109	serine/threonine kinase 11	Homo sapiens	82-86
18636417-1	2008	We previously reported that radicicol (Rad) and geldanamycin (Geld), heat shock protein 90 (Hsp90) inhibitors, potentiate neurite growth of cultured sensory neurons from chick embryo.	monorden	28-37	heat shock protein, 2	Mus musculus	69-90
18636417-1	2008	We previously reported that radicicol (Rad) and geldanamycin (Geld), heat shock protein 90 (Hsp90) inhibitors, potentiate neurite growth of cultured sensory neurons from chick embryo.	monorden	28-37	heat shock protein, 2	Mus musculus	92-97
18667483-10	2008	HSP90 inhibition with radicicol produced a fall in RBF and GFR that was associated with a significant reduction of UNO2/NO3V.	monorden	22-31	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	0-5
18808717-8	2008	Treatment of the yeast with the specific HSP90 inhibitors geldanamycin and radicicol inhibited growth at 2 and 10 microM, respectively.	monorden	75-84	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	41-46
18358234-2	2008	In this work we show that the level of Sgt1 is increased in HEp-2 cells exposed to heat shock or radicicol.	monorden	97-106	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone	Homo sapiens	39-43
19850986-0	2008	Radicicol-mediated inhibition of Bcr-Abl in K562 cells induced p38-MAPK dependent erythroid differentiation and PU.1 down-regulation.	monorden	0-9	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	33-40
18440021-0	2008	The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ.	monorden	20-29	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
18440021-3	2008	Using crystallographic approaches, we show that radicicol (an Hsp90 inhibitor) binds and interacts specifically with residues in the ATP-binding pocket of PhoQ.	monorden	48-57	heat shock protein 90 alpha family class A member 1	Homo sapiens	62-67
18440021-4	2008	The interaction between radicicol and PhoQcat demonstrates significant similarities as well as differences compared to AMPPNP (a non-hydrolyzable ATP analog) bound to PhoQcat and radicicol bound to Hsp90.	monorden	24-33	heat shock protein 90 alpha family class A member 1	Homo sapiens	198-203
18440021-4	2008	The interaction between radicicol and PhoQcat demonstrates significant similarities as well as differences compared to AMPPNP (a non-hydrolyzable ATP analog) bound to PhoQcat and radicicol bound to Hsp90.	monorden	179-188	heat shock protein 90 alpha family class A member 1	Homo sapiens	198-203
18313664-4	2008	Various pre- and clinical studies have revealed that heat shock protein 90 (HSP90) inhibitors, such as geldanamycin and radicicol, are promising drugs in the treatment of different malignant processes.	monorden	120-129	heat shock protein 90 alpha family class A member 1	Homo sapiens	53-74
18313664-4	2008	Various pre- and clinical studies have revealed that heat shock protein 90 (HSP90) inhibitors, such as geldanamycin and radicicol, are promising drugs in the treatment of different malignant processes.	monorden	120-129	heat shock protein 90 alpha family class A member 1	Homo sapiens	76-81
18313664-6	2008	Our findings indicate that geldanamycin and radicicol increased HSP70 and HSP27 expression analyzed by western blotting.	monorden	44-53	heat shock protein family A (Hsp70) member 4	Homo sapiens	64-69
18313664-6	2008	Our findings indicate that geldanamycin and radicicol increased HSP70 and HSP27 expression analyzed by western blotting.	monorden	44-53	heat shock protein family B (small) member 1	Homo sapiens	74-79
18245267-5	2008	Pretreatment with the hsp90 inhibitor, radicicol, prevented the decrease in TER, maintained VE-cadherin and beta-catenin expression, and inhibited activation of pp60(Src) and phosphorylation of paxillin.	monorden	39-48	heat shock protein 86, pseudogene 1	Mus musculus	22-27
18245267-5	2008	Pretreatment with the hsp90 inhibitor, radicicol, prevented the decrease in TER, maintained VE-cadherin and beta-catenin expression, and inhibited activation of pp60(Src) and phosphorylation of paxillin.	monorden	39-48	cadherin 5	Mus musculus	92-103
18245267-5	2008	Pretreatment with the hsp90 inhibitor, radicicol, prevented the decrease in TER, maintained VE-cadherin and beta-catenin expression, and inhibited activation of pp60(Src) and phosphorylation of paxillin.	monorden	39-48	catenin (cadherin associated protein), beta 1	Mus musculus	108-120
18245267-5	2008	Pretreatment with the hsp90 inhibitor, radicicol, prevented the decrease in TER, maintained VE-cadherin and beta-catenin expression, and inhibited activation of pp60(Src) and phosphorylation of paxillin.	monorden	39-48	Rous sarcoma oncogene	Mus musculus	166-169
18245267-7	2008	Increased paxillin phosphorylation and decreased expression of beta-catenin and VE-cadherin were also observed in mouse lungs 12 h after intraperitoneal endotoxin and attenuated in mice pretreated with radicicol.	monorden	202-211	catenin (cadherin associated protein), beta 1	Mus musculus	63-75
18245267-7	2008	Increased paxillin phosphorylation and decreased expression of beta-catenin and VE-cadherin were also observed in mouse lungs 12 h after intraperitoneal endotoxin and attenuated in mice pretreated with radicicol.	monorden	202-211	cadherin 5	Mus musculus	80-91
18175893-3	2008	Radicicol alleviated analogous physiological effects due to the expression of a constitutively active form of calcineurin or overexpression of Swe1, the negative regulatory kinase of the Cdc28-Clb complex.	monorden	0-9	tyrosine protein kinase SWE1	Saccharomyces cerevisiae S288C	143-147
18175893-3	2008	Radicicol alleviated analogous physiological effects due to the expression of a constitutively active form of calcineurin or overexpression of Swe1, the negative regulatory kinase of the Cdc28-Clb complex.	monorden	0-9	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	187-192
18175893-4	2008	Western blot analysis indicated that radicicol inhibited Ca(2+)-induced accumulation of Swe1 and Cln2.	monorden	37-46	tyrosine protein kinase SWE1	Saccharomyces cerevisiae S288C	88-92
18175893-4	2008	Western blot analysis indicated that radicicol inhibited Ca(2+)-induced accumulation of Swe1 and Cln2.	monorden	37-46	cyclin CLN2	Saccharomyces cerevisiae S288C	97-101
19850986-0	2008	Radicicol-mediated inhibition of Bcr-Abl in K562 cells induced p38-MAPK dependent erythroid differentiation and PU.1 down-regulation.	monorden	0-9	mitogen-activated protein kinase 14	Homo sapiens	63-66
19850986-3	2008	Here, we used natural product Radicicol (Rad), a macrocyclic antifungal, as an Hsp90 inhibitor to investigate the effect of Bcr-Abl inactivation on erythroid gene expression and subsequently on the transcription factors involved in their regulation.	monorden	30-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	79-84
19568319-2	2008	Utilizing our chimera approach, which encompasses the quinone moiety of geldanamycin and the resorcinol moiety of radicicol, molecules have been produced that are highly effective inhibitors of the Hsp90 protein folding machinery.	monorden	114-123	heat shock protein 90 alpha family class A member 1	Homo sapiens	198-203
17928289-8	2007	The ACL inhibitor radicicol also curtailed GIIS.	monorden	18-27	ATP citrate lyase	Rattus norvegicus	4-7
17827253-7	2007	Conversely, the exposure of PAECs isolated from fetal lambs to the HSP90 inhibitor radicicol led to significant decreases in eNOS-HSP90 interactions, decreased shear-stimulated NO generation, and increased NOS-dependent superoxide production indicative of eNOS uncoupling.	monorden	83-92	heat shock protein 90 alpha family class A member 1	Homo sapiens	67-72
17827253-7	2007	Conversely, the exposure of PAECs isolated from fetal lambs to the HSP90 inhibitor radicicol led to significant decreases in eNOS-HSP90 interactions, decreased shear-stimulated NO generation, and increased NOS-dependent superoxide production indicative of eNOS uncoupling.	monorden	83-92	NOS type III	Ovis aries	125-129
17827253-7	2007	Conversely, the exposure of PAECs isolated from fetal lambs to the HSP90 inhibitor radicicol led to significant decreases in eNOS-HSP90 interactions, decreased shear-stimulated NO generation, and increased NOS-dependent superoxide production indicative of eNOS uncoupling.	monorden	83-92	heat shock protein 90 alpha family class A member 1	Homo sapiens	130-135
17827253-7	2007	Conversely, the exposure of PAECs isolated from fetal lambs to the HSP90 inhibitor radicicol led to significant decreases in eNOS-HSP90 interactions, decreased shear-stimulated NO generation, and increased NOS-dependent superoxide production indicative of eNOS uncoupling.	monorden	83-92	NOS type III	Ovis aries	256-260
17764690-3	2007	Hydrogen-exchange mass spectrometry was used to study the structural and conformational changes undergone by full-length human Hsp90beta in solution upon binding of the kinase-specific co-chaperone Cdc37 and two Hsp90 ATPase inhibitors: Radicicol and the first-generation anticancer drug DMAG.	monorden	237-246	heat shock protein 90 alpha family class B member 1	Homo sapiens	127-136
17764690-3	2007	Hydrogen-exchange mass spectrometry was used to study the structural and conformational changes undergone by full-length human Hsp90beta in solution upon binding of the kinase-specific co-chaperone Cdc37 and two Hsp90 ATPase inhibitors: Radicicol and the first-generation anticancer drug DMAG.	monorden	237-246	heat shock protein 90 alpha family class A member 1	Homo sapiens	127-132
17681020-0	2007	Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.	monorden	231-240	heat shock protein 90 alpha family class A member 1	Homo sapiens	75-80
17525289-5	2007	17-AAG and radicicol also induced splicing of XBP1, with the induction of CHOP and activation of ATF6, whereas bortezomib resulted in the induction of CHOP and activation of ATF6 with minimal effects on XBP1.	monorden	11-20	X-box binding protein 1	Homo sapiens	46-50
17525289-5	2007	17-AAG and radicicol also induced splicing of XBP1, with the induction of CHOP and activation of ATF6, whereas bortezomib resulted in the induction of CHOP and activation of ATF6 with minimal effects on XBP1.	monorden	11-20	DNA damage inducible transcript 3	Homo sapiens	74-78
17525289-5	2007	17-AAG and radicicol also induced splicing of XBP1, with the induction of CHOP and activation of ATF6, whereas bortezomib resulted in the induction of CHOP and activation of ATF6 with minimal effects on XBP1.	monorden	11-20	activating transcription factor 6	Homo sapiens	97-101
17513464-5	2007	We review the various classes of HSP90 inhibitor that have been developed, including the natural products geldanamycin and radicicol and also the purine scaffold and pyrazole/isoxazole class of synthetic small molecule inhibitors.	monorden	123-132	heat shock protein 90 alpha family class A member 1	Homo sapiens	33-38
17681020-0	2007	Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.	monorden	231-240	heat shock protein 90 alpha family class B member 1	Homo sapiens	176-185
17681020-0	2007	Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.	monorden	231-240	heat shock protein 90 alpha family class A member 1	Homo sapiens	75-80
17681020-7	2007	Remarkably, whereas expression of Hsp90beta as the sole Hsp90 of yeast rendered cells highly sensitive to the Hsp90 inhibitor radicicol, comparable expression of Hsp90alpha did not.	monorden	126-135	heat shock protein 90 alpha family class B member 1	Homo sapiens	34-43
17681020-7	2007	Remarkably, whereas expression of Hsp90beta as the sole Hsp90 of yeast rendered cells highly sensitive to the Hsp90 inhibitor radicicol, comparable expression of Hsp90alpha did not.	monorden	126-135	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	34-39
17681020-7	2007	Remarkably, whereas expression of Hsp90beta as the sole Hsp90 of yeast rendered cells highly sensitive to the Hsp90 inhibitor radicicol, comparable expression of Hsp90alpha did not.	monorden	126-135	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	56-61
17683942-2	2007	We have determined structures of human PDK1 or PDK3 bound to the inhibitors AZD7545, dichloroacetate (DCA), and radicicol.	monorden	112-121	pyruvate dehydrogenase kinase 1	Homo sapiens	39-43
17683942-2	2007	We have determined structures of human PDK1 or PDK3 bound to the inhibitors AZD7545, dichloroacetate (DCA), and radicicol.	monorden	112-121	pyruvate dehydrogenase kinase 3	Homo sapiens	47-51
17337508-6	2007	Hsp90 inhibition with GA or RA reduced ACh-mediated dilation, abolished the ACh-stimulated increase in cGMP, and reduced eNOS:Hsp90 coprecipitation.	monorden	28-30	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
17337508-6	2007	Hsp90 inhibition with GA or RA reduced ACh-mediated dilation, abolished the ACh-stimulated increase in cGMP, and reduced eNOS:Hsp90 coprecipitation.	monorden	28-30	heat shock protein 90 alpha family class A member 1	Homo sapiens	126-131
17401665-0	2007	Effect of radicicol infusion on the Src tyrosine kinase activity of rat hippocampus before and after training in an inhibitory avoidance task.	monorden	10-19	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	36-39
17401665-3	2007	Previous work showed that intra-hippocampal infusion of the Src-PTK inhibitor radicicol inhibits memory acquisition, consolidation, and retrieval of one-trial step-down inhibitory avoidance task.	monorden	78-87	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	60-63
17401665-5	2007	Radicicol (0.5 microg/ml) was infused into the CA1 region of the hippocampus of rats trained in a one-trial step-down inhibitory avoidance task.	monorden	0-9	carbonic anhydrase 1	Rattus norvegicus	47-50
17401665-6	2007	Radicicol infused 15 min before training decreased Src-PTK activity, as measured 0, 1.5, and 24 h after training, and impaired memory acquisition of the task.	monorden	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	51-54
17401665-9	2007	Radicicol infused into CA1 10 min prior to retrieval testing inhibited hippocampal Src-PTK activity, as measured immediately after the test session.	monorden	0-9	carbonic anhydrase 1	Rattus norvegicus	23-26
17401665-9	2007	Radicicol infused into CA1 10 min prior to retrieval testing inhibited hippocampal Src-PTK activity, as measured immediately after the test session.	monorden	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	83-86
17683942-8	2007	Finally, radicicol inhibits kinase activity by binding directly to the ATP-binding pocket of PDK3, similar to Hsp90 and Topo VI from the same ATPase/kinase superfamily.	monorden	9-18	pyruvate dehydrogenase kinase 3	Homo sapiens	93-97
17683942-8	2007	Finally, radicicol inhibits kinase activity by binding directly to the ATP-binding pocket of PDK3, similar to Hsp90 and Topo VI from the same ATPase/kinase superfamily.	monorden	9-18	heat shock protein 90 alpha family class A member 1	Homo sapiens	110-115
17337278-0	2007	Protective effect of radicicol against LPS/IFN-gamma-induced neuronal cell death in rat cortical neuron-glia cultures.	monorden	21-30	interferon gamma	Rattus norvegicus	43-52
17337278-2	2007	Radicicol potently prevented the loss of neuronal cell bodies and neurites from LPS/IFN-gamma-induced neurotoxicity in rat cortical neuron-glia cultures with an EC(50) value of 0.09 microM.	monorden	0-9	interferon gamma	Rattus norvegicus	80-93
17337278-3	2007	Radicicol inhibited the LPS/IFN-gamma-induced expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO) in microglia.	monorden	0-9	interferon gamma	Rattus norvegicus	24-37
17337278-3	2007	Radicicol inhibited the LPS/IFN-gamma-induced expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO) in microglia.	monorden	0-9	nitric oxide synthase 2	Rattus norvegicus	60-91
17337278-3	2007	Radicicol inhibited the LPS/IFN-gamma-induced expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO) in microglia.	monorden	0-9	nitric oxide synthase 2	Rattus norvegicus	93-97
17337278-4	2007	Additionally, radicicol decreased the LPS/IFN-gamma-induced release of tumor necrosis factor-alpha (TNF-alpha) in the cultures.	monorden	14-23	interferon gamma	Rattus norvegicus	38-51
17337278-4	2007	Additionally, radicicol decreased the LPS/IFN-gamma-induced release of tumor necrosis factor-alpha (TNF-alpha) in the cultures.	monorden	14-23	tumor necrosis factor	Rattus norvegicus	71-98
17337278-4	2007	Additionally, radicicol decreased the LPS/IFN-gamma-induced release of tumor necrosis factor-alpha (TNF-alpha) in the cultures.	monorden	14-23	tumor necrosis factor	Rattus norvegicus	100-109
17337278-5	2007	The inhibitory potency of radicicol against the production of NO and TNF-alpha was well correlated with the protection of neurons.	monorden	26-35	tumor necrosis factor	Rattus norvegicus	69-78
17337278-6	2007	These results suggest that the protective effect of radicicol against LPS/IFN-gamma-induced neuronal cell death in neuron-glia cultures is mediated via the inhibition of TNF-alpha release, as well as the suppression of iNOS expression in microglia.	monorden	52-61	interferon gamma	Rattus norvegicus	74-83
17337278-6	2007	These results suggest that the protective effect of radicicol against LPS/IFN-gamma-induced neuronal cell death in neuron-glia cultures is mediated via the inhibition of TNF-alpha release, as well as the suppression of iNOS expression in microglia.	monorden	52-61	tumor necrosis factor	Rattus norvegicus	170-179
17337278-6	2007	These results suggest that the protective effect of radicicol against LPS/IFN-gamma-induced neuronal cell death in neuron-glia cultures is mediated via the inhibition of TNF-alpha release, as well as the suppression of iNOS expression in microglia.	monorden	52-61	nitric oxide synthase 2	Rattus norvegicus	219-223
17114002-0	2006	Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.	monorden	139-148	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-19
17332351-6	2007	X-ray crystallographic structures of the NH(2)-terminal domain of yeast Hsp90 complexed with CCT018159 or its analogues showed binding properties similar to radicicol.	monorden	157-166	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	72-77
17260968-5	2007	Although the hsp90 inhibitor radicicol delayed nuclear translocation, it did not prevent complete nuclear accumulation of MR at longer incubation times (t0.5 = 30-40 min).	monorden	29-38	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	13-18
17279252-1	2007	While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products.	monorden	104-113	heat shock protein 90 alpha family class A member 1	Homo sapiens	140-145
16959221-0	2006	The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase.	monorden	45-54	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
17323946-0	2007	Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol.	monorden	121-130	heat shock protein 90 alpha family class A member 1	Homo sapiens	84-89
17323946-4	2007	Geldanamycin and radicicol are structurally different macrocycles determined by X-ray crystallography to bind to a common site on the cellular chaperone heat shock protein 90 (Hsp90).	monorden	17-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	153-174
17323946-4	2007	Geldanamycin and radicicol are structurally different macrocycles determined by X-ray crystallography to bind to a common site on the cellular chaperone heat shock protein 90 (Hsp90).	monorden	17-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	176-181
16679377-8	2006	Treatment with radicicol had no effect on 20-HETE-induced relaxation of pulmonary arteries, consistent with an absence of effect on association of Hsp90 to eNOS, whereas radicicol partially blocked VEGF-evoked relaxations, possibly secondary to effects on endpoints other than Hsp90 association with eNOS.	monorden	170-179	vascular endothelial growth factor A	Bos taurus	198-202
17073714-5	2006	Numerous classes of Hsp90 inhibitors have recently been developed, such as the anasamysin geldanamycin and derivatives 17-AAG and 17-DMAG; the macrolide radicicol and derivatives; purine-scaffold derivatives; pyrazoles; and shepherdins that bind to the N-terminal high-affinity ATP-binding domain of Hsp90.	monorden	153-162	heat shock protein 90 alpha family class A member 1	Homo sapiens	20-25
16995666-2	2006	Previous studies have demonstrated that the natural products, radicicol and geldanamycin, are potent inhibitors of the Hsp90 N-terminal ATP binding site.	monorden	62-71	heat shock protein 90 alpha family class A member 1	Homo sapiens	119-124
16995666-3	2006	The cocrystal structures of these molecules bound to Hsp90 have been determined, and through molecular modeling and superimposition of these ligands, hybrids of radicicol and geldanamycin have been designed.	monorden	161-170	heat shock protein 90 alpha family class A member 1	Homo sapiens	53-58
16995666-4	2006	A series of macrocylic chimeras of radicicol and geldanamycin and the corresponding seco-agents have been prepared and evaluated for both antiproliferative activity and their ability to induce Hsp90-dependent client protein degradation.	monorden	35-44	heat shock protein 90 alpha family class A member 1	Homo sapiens	193-198
16950627-4	2006	Two other Hsp90 inhibitors, 17-allylamino-17-demethoxygeldanamycin (17-AAG) and radicicol, and pyrrolidine dithiocarbamate induced robust expression of Hsp70 and Hsp40 in motor neurons, but at cytotoxic concentrations.	monorden	80-89	heat shock protein 90 alpha family class A member 1	Homo sapiens	10-15
16950627-4	2006	Two other Hsp90 inhibitors, 17-allylamino-17-demethoxygeldanamycin (17-AAG) and radicicol, and pyrrolidine dithiocarbamate induced robust expression of Hsp70 and Hsp40 in motor neurons, but at cytotoxic concentrations.	monorden	80-89	heat shock protein family A (Hsp70) member 4	Homo sapiens	152-157
16950627-4	2006	Two other Hsp90 inhibitors, 17-allylamino-17-demethoxygeldanamycin (17-AAG) and radicicol, and pyrrolidine dithiocarbamate induced robust expression of Hsp70 and Hsp40 in motor neurons, but at cytotoxic concentrations.	monorden	80-89	DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1	Homo sapiens	162-167
16806077-3	2006	The use of this system for the identification and characterization of HIF-1 effectors was first validated by showing that two chemical Hsp90 inhibitors, geldanamycin and radicicol, impaired the activity of HIF-1 in yeast.	monorden	170-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-75
16806077-3	2006	The use of this system for the identification and characterization of HIF-1 effectors was first validated by showing that two chemical Hsp90 inhibitors, geldanamycin and radicicol, impaired the activity of HIF-1 in yeast.	monorden	170-179	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	135-140
16513847-6	2006	An enhanced loss of E47 cell viability was also observed using two different inhibitors of Hsp90, herbimycin A and radicicol.	monorden	115-124	heat shock protein 90 alpha family class A member 1	Homo sapiens	91-96
16489110-8	2006	Similarly to their effects on NO-donor-induced relaxation, 15-h exposure to RA, but not to GA, decreased hsp90-bound sGC protein expression and NTG-stimulated cGMP formation in aortic rings, whereas RA more than GA reduced SNN-stimulated cGMP formation.	monorden	76-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	105-110
16489110-9	2006	We conclude that RA, much more so than GA, selectively inhibits sGC-dependent relaxations of aortic rings by reducing sGC expression, disrupting sGC-hsp90 complex formation and decreasing cGMP formation.	monorden	17-19	heat shock protein 90 alpha family class A member 1	Homo sapiens	149-154
16806077-3	2006	The use of this system for the identification and characterization of HIF-1 effectors was first validated by showing that two chemical Hsp90 inhibitors, geldanamycin and radicicol, impaired the activity of HIF-1 in yeast.	monorden	170-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	206-211
16687576-4	2006	ER-to-Golgi traffic is inhibited by the Hsp90-specific inhibitors geldanamycin (GA), 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), and radicicol.	monorden	154-163	heat shock protein 90 alpha family class A member 1	Homo sapiens	40-45
16385570-7	2006	The Hsp90 inhibitors geldanamycin, 17-AAG (17-allylamino-17-demethoxygeldanamycin) and radicicol significantly enhanced the activity of the topoisomerase II poisons etoposide and mitoxantrone in vitro and in vivo.	monorden	87-96	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
16495214-4	2006	We found that low concentrations of the specific Hsp90 inhibitors, geldanamycin and radicicol, completely blocked the translocation of FGF-1 and FGF-2 to the cytosol and the nucleus.	monorden	84-93	heat shock protein 90 alpha family class A member 1	Homo sapiens	49-54
16495214-4	2006	We found that low concentrations of the specific Hsp90 inhibitors, geldanamycin and radicicol, completely blocked the translocation of FGF-1 and FGF-2 to the cytosol and the nucleus.	monorden	84-93	fibroblast growth factor 1	Homo sapiens	135-140
16495214-4	2006	We found that low concentrations of the specific Hsp90 inhibitors, geldanamycin and radicicol, completely blocked the translocation of FGF-1 and FGF-2 to the cytosol and the nucleus.	monorden	84-93	fibroblast growth factor 2	Homo sapiens	145-150
16499313-0	2006	Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.	monorden	93-102	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	11-16
16464590-1	2006	Radicicol and geldanamycin are potent inhibitors of the Hsp90 protein folding machinery, which is an emerging target for the development of cancer chemotherapeutics.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	56-61
16291818-3	2006	Histological analysis showed that the muscles from both HSP70 and wild-type mice treated with radicicol (a HSP inducer) had decreased necrosis after cryolesioning compared with controls.	monorden	94-103	heat shock protein 1B	Mus musculus	56-61
16499313-2	2006	Bioassay-guided fractionation of extracts active in these assays derived from Chaetomium chiversii and Paraphaeosphaeria quadriseptata furnished the Hsp90 inhibitors radicicol (1) and monocillin I (2), respectively.	monorden	166-175	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	149-154
16499313-4	2006	Radicicol and monocillin I were also evaluated in a solid-phase competition assay for their ability to bind Hsp90 and to deplete cellular levels of two known Hsp90 client proteins with relevance to breast cancer, estrogen receptor (ER), and the type 1 insulin-like growth factor receptor (IGF-1R).	monorden	0-9	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	108-113
16499313-4	2006	Radicicol and monocillin I were also evaluated in a solid-phase competition assay for their ability to bind Hsp90 and to deplete cellular levels of two known Hsp90 client proteins with relevance to breast cancer, estrogen receptor (ER), and the type 1 insulin-like growth factor receptor (IGF-1R).	monorden	0-9	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	158-163
16499313-6	2006	Isolation of radicicol and monocillin I in this study provides evidence that we have developed an effective strategy for discovering natural product-based Hsp90 inhibitors with potential anticancer activity.	monorden	13-22	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	155-160
16842153-7	2006	These studies rapidly enhanced our understanding of Hsp90 function and led to the identification of radicicol as a structurally distinct Hsp90 inhibitor.	monorden	100-109	heat shock protein 90 alpha family class A member 1	Homo sapiens	137-142
16321010-3	2005	This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.	monorden	43-52	heat shock protein 90 alpha family class A member 1	Homo sapiens	94-99
16049054-6	2006	Inhibition of Hsp90 by two specific inhibitors, geldanamycin or radicicol, did not affect total amounts of ClC-2 but did reduce plasma membrane channel abundance.	monorden	64-73	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-19
16173045-1	2006	Both geldanamycin (GA) and radicicol (RA) are HSP90 binding agents that possess antitumour activities.	monorden	27-36	heat shock protein 90 alpha family class A member 1	Homo sapiens	46-51
16173045-1	2006	Both geldanamycin (GA) and radicicol (RA) are HSP90 binding agents that possess antitumour activities.	monorden	38-40	heat shock protein 90 alpha family class A member 1	Homo sapiens	46-51
16920739-0	2006	Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol.	monorden	72-81	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-66
16920739-3	2006	Recently, it was found that radicicol, a drug known to block Hsp90 function, also inhibits the archaeal type IIB topoisomerase topo VI.	monorden	28-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-66
16920739-4	2006	Here, we use X-ray crystallography to show that despite low sequence identity ( approximately 10-12%) between topo VI and Hsp90, radicicol binds to the ATPase sites of these two enzymes in an equivalent manner.	monorden	129-138	heat shock protein 90 alpha family class A member 1	Homo sapiens	122-127
16331994-3	2005	We show here that treatment of transformed human skin fibroblasts stably expressing CYP2E1 with the hsp90 inhibitor radicicol results in CYP2E1 degradation that is inhibited by the proteasome inhibitor lactacystin.	monorden	116-125	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	84-90
16331994-3	2005	We show here that treatment of transformed human skin fibroblasts stably expressing CYP2E1 with the hsp90 inhibitor radicicol results in CYP2E1 degradation that is inhibited by the proteasome inhibitor lactacystin.	monorden	116-125	heat shock protein 90 alpha family class A member 1	Homo sapiens	100-105
16331994-3	2005	We show here that treatment of transformed human skin fibroblasts stably expressing CYP2E1 with the hsp90 inhibitor radicicol results in CYP2E1 degradation that is inhibited by the proteasome inhibitor lactacystin.	monorden	116-125	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	137-143
16842154-4	2006	Recent work has produced improved radicicol analogues that show promising Hsp90 inhibitory activity in vitro.	monorden	34-43	heat shock protein 90 alpha family class A member 1	Homo sapiens	74-79
16842156-3	2006	Hsp90 has an ATPase domain that is necessary for its Hsp chaperone function, and X-ray crystallography has shown that natural product inhibitors (geldanamycin, radicicol) of Hsp90 function bind to this domain.	monorden	160-169	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
16842156-3	2006	Hsp90 has an ATPase domain that is necessary for its Hsp chaperone function, and X-ray crystallography has shown that natural product inhibitors (geldanamycin, radicicol) of Hsp90 function bind to this domain.	monorden	160-169	heat shock protein 90 alpha family class A member 1	Homo sapiens	174-179
16273226-0	2005	Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin.	monorden	73-82	mutL homolog 1	Homo sapiens	12-16
16273226-0	2005	Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin.	monorden	73-82	heat shock protein 90 alpha family class A member 1	Homo sapiens	57-62
16273226-6	2005	This indicates that the presence of MLH1 protein aggravates the radicicol-imposed increase in sensitivity of cells to cisplatin but not to oxaliplatin.	monorden	64-73	mutL homolog 1	Homo sapiens	36-40
16273226-2	2005	An experimental approach was designed to determine whether the presence or absence of MLH1 affects the potential of radicicol to increase the sensitivity of tumor cells to cisplatin and oxaliplatin, and whether perhaps radicicol increases sensitivity to cisplatin specifically in cisplatin-resistant, MLH1-deficient cells.	monorden	116-125	mutL homolog 1	Homo sapiens	86-90
16273226-3	2005	Radicicol is a novel specific inhibitor for heat shock protein 90 (HSP90) and structurally unrelated to geldanamycin.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	44-65
16273226-3	2005	Radicicol is a novel specific inhibitor for heat shock protein 90 (HSP90) and structurally unrelated to geldanamycin.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	67-72
16273226-4	2005	Clonogenic data demonstrated that sublethal concentrations of radicicol increased the sensitivity to cisplatin and to oxaliplatin in both MLH1-proficient cells and MLH1-deficient cells.	monorden	62-71	mutL homolog 1	Homo sapiens	138-142
16024662-6	2005	The physiological importance of the hsp90/sGC interaction was investigated by treating rat smooth muscle cells with the hsp90 inhibitors radicicol and geldanamycin (GA) and determining both sGC activity and protein levels.	monorden	137-146	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	36-41
16024662-6	2005	The physiological importance of the hsp90/sGC interaction was investigated by treating rat smooth muscle cells with the hsp90 inhibitors radicicol and geldanamycin (GA) and determining both sGC activity and protein levels.	monorden	137-146	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	42-45
16024662-6	2005	The physiological importance of the hsp90/sGC interaction was investigated by treating rat smooth muscle cells with the hsp90 inhibitors radicicol and geldanamycin (GA) and determining both sGC activity and protein levels.	monorden	137-146	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	120-125
15930315-9	2005	In addition to 17-AAG, other Hsp90 inhibitors, such as radicicol and herbimycin A, also enhanced osteoclastogenesis.	monorden	55-64	heat shock protein, 3	Mus musculus	29-34
15890922-4	2005	Treatment of FHV-infected Drosophila S2 cells with the Hsp90-specific inhibitor geldanamycin or radicicol potently suppressed the production of infectious virions and the accumulation of protein A and genomic, subgenomic, and template viral RNA.	monorden	96-105	protein A;protein B1	Flock House virus	187-196
15901158-2	2005	The antitumor antibiotics radicicol and geldanamycin are potent inhibitors of the Hsp90 protein folding machinery.	monorden	26-35	heat shock protein 90 alpha family class A member 1	Homo sapiens	82-87
15782129-6	2005	We also examined the effect of Radicicol (RA), a drug with higher affinity than GA for HSP90.	monorden	42-44	heat shock protein 90 alpha family class A member 1	Homo sapiens	87-92
15782129-7	2005	RA displays uPA activity inhibition at nanomolar levels, but not at lower concentrations, indicating that HSP90 is not likely the fM-GAi molecular target.	monorden	0-2	plasminogen activator, urokinase	Homo sapiens	12-15
15737995-6	2005	Both geldanamycin and radicicol, two structurally different Hsp90 inhibitors, selectively reduced serine 1179-phosphorylated eNOS, leading to decreased enzyme activity.	monorden	22-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	60-65
15737995-6	2005	Both geldanamycin and radicicol, two structurally different Hsp90 inhibitors, selectively reduced serine 1179-phosphorylated eNOS, leading to decreased enzyme activity.	monorden	22-31	nitric oxide synthase 3	Homo sapiens	125-129
15843522-7	2005	In addition, radicicol, an inhibitor of heat shock protein 90 (Hsp90), and rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), blocked IL-2-induced hTERT activity and nuclear translocation of hTERT but not hTERT mRNA expression.	monorden	13-22	heat shock protein 90 alpha family class A member 1	Homo sapiens	40-61
15843522-7	2005	In addition, radicicol, an inhibitor of heat shock protein 90 (Hsp90), and rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), blocked IL-2-induced hTERT activity and nuclear translocation of hTERT but not hTERT mRNA expression.	monorden	13-22	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-68
15843522-7	2005	In addition, radicicol, an inhibitor of heat shock protein 90 (Hsp90), and rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), blocked IL-2-induced hTERT activity and nuclear translocation of hTERT but not hTERT mRNA expression.	monorden	13-22	interleukin 2	Homo sapiens	152-156
15843522-7	2005	In addition, radicicol, an inhibitor of heat shock protein 90 (Hsp90), and rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), blocked IL-2-induced hTERT activity and nuclear translocation of hTERT but not hTERT mRNA expression.	monorden	13-22	telomerase reverse transcriptase	Homo sapiens	165-170
15843522-7	2005	In addition, radicicol, an inhibitor of heat shock protein 90 (Hsp90), and rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), blocked IL-2-induced hTERT activity and nuclear translocation of hTERT but not hTERT mRNA expression.	monorden	13-22	telomerase reverse transcriptase	Homo sapiens	209-214
15843522-7	2005	In addition, radicicol, an inhibitor of heat shock protein 90 (Hsp90), and rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), blocked IL-2-induced hTERT activity and nuclear translocation of hTERT but not hTERT mRNA expression.	monorden	13-22	telomerase reverse transcriptase	Homo sapiens	209-214
15358769-2	2004	We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 binding to the p21 promoter sequence.	monorden	29-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-68
15744362-3	2004	In contrast, radicicol, an inhibitor of Hsp90, inhibited fMLP-induced oxidative burst in time and concentration-dependent manner where IC50 value for 30 min pre-incubation was 16.5 +/- 3.5 microM radicicol.	monorden	13-22	heat shock protein 90 alpha family class A member 1	Homo sapiens	40-45
15744362-3	2004	In contrast, radicicol, an inhibitor of Hsp90, inhibited fMLP-induced oxidative burst in time and concentration-dependent manner where IC50 value for 30 min pre-incubation was 16.5 +/- 3.5 microM radicicol.	monorden	13-22	formyl peptide receptor 1	Homo sapiens	57-61
15744362-3	2004	In contrast, radicicol, an inhibitor of Hsp90, inhibited fMLP-induced oxidative burst in time and concentration-dependent manner where IC50 value for 30 min pre-incubation was 16.5 +/- 3.5 microM radicicol.	monorden	196-205	heat shock protein 90 alpha family class A member 1	Homo sapiens	40-45
15744362-3	2004	In contrast, radicicol, an inhibitor of Hsp90, inhibited fMLP-induced oxidative burst in time and concentration-dependent manner where IC50 value for 30 min pre-incubation was 16.5 +/- 3.5 microM radicicol.	monorden	196-205	formyl peptide receptor 1	Homo sapiens	57-61
15501584-2	2004	As shown by immunofluorescence staining and immunoblot analysis, the Hsp90 inhibitor radicicol induced a rapid (within hours) depletion of estrogen receptor-alpha (ER) in MCF-7 and IBEP-2 breast carcinoma cells.	monorden	85-94	heat shock protein 90 alpha family class A member 1	Homo sapiens	69-74
15501584-2	2004	As shown by immunofluorescence staining and immunoblot analysis, the Hsp90 inhibitor radicicol induced a rapid (within hours) depletion of estrogen receptor-alpha (ER) in MCF-7 and IBEP-2 breast carcinoma cells.	monorden	85-94	estrogen receptor 1	Homo sapiens	139-162
15583003-9	2005	Blockade of endothelial NOS (eNOS) activation using geldanamycin and radicicol, inhibitors of heat shock protein 90, in endothelium-intact arteries suppressed both LPS-induced relaxation and LPS-induced iNOS expression (9.0 +/- 8.0% and 2.0 +/- 6.2%, respectively).	monorden	69-78	nitric oxide synthase 3	Homo sapiens	12-27
15583003-9	2005	Blockade of endothelial NOS (eNOS) activation using geldanamycin and radicicol, inhibitors of heat shock protein 90, in endothelium-intact arteries suppressed both LPS-induced relaxation and LPS-induced iNOS expression (9.0 +/- 8.0% and 2.0 +/- 6.2%, respectively).	monorden	69-78	toll-like receptor 4	Mus musculus	164-167
15583003-9	2005	Blockade of endothelial NOS (eNOS) activation using geldanamycin and radicicol, inhibitors of heat shock protein 90, in endothelium-intact arteries suppressed both LPS-induced relaxation and LPS-induced iNOS expression (9.0 +/- 8.0% and 2.0 +/- 6.2%, respectively).	monorden	69-78	toll-like receptor 4	Mus musculus	191-194
15583003-9	2005	Blockade of endothelial NOS (eNOS) activation using geldanamycin and radicicol, inhibitors of heat shock protein 90, in endothelium-intact arteries suppressed both LPS-induced relaxation and LPS-induced iNOS expression (9.0 +/- 8.0% and 2.0 +/- 6.2%, respectively).	monorden	69-78	nitric oxide synthase 2	Homo sapiens	203-207
15962764-0	2005	Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor.	monorden	59-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-21
15962764-0	2005	Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor.	monorden	59-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	23-28
15962764-0	2005	Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor.	monorden	59-68	androgen receptor	Homo sapiens	189-206
15962764-5	2005	Radicicol was used as one of the known Hsp90 chaperone complex inhibitors, and the cells were incubated in the presence of this compound at a concentration of 500 nM.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	39-44
15358769-2	2004	We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 binding to the p21 promoter sequence.	monorden	29-38	tumor protein p53	Homo sapiens	98-101
15358769-2	2004	We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 binding to the p21 promoter sequence.	monorden	29-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	117-120
15239664-2	2004	Inhibition of the ATPase activity of Hsp90 by natural products (e.g., 17-allylaminogeldanamycin or radicicol) leads to the ubiquitination of oncogenic client proteins such as Her-2, Raf-1, and p-Akt followed by their proteasomal degradation.	monorden	99-108	heat shock protein 90 alpha family class A member 1	Homo sapiens	37-42
15475476-6	2004	Here, the authors present the development of a homogenous assay based on 2-dimensional fluorescence intensity distribution analysis of tetramethyl-rhodamine (TAMRA)-labeled radicicol bound to Hsp90beta.	monorden	173-182	heat shock protein 90 alpha family class B member 1	Homo sapiens	192-201
15364548-11	2004	Furthermore, the addition of the hsp90 inhibitors geldanamycin, herbimycin, and radicicol had no effect on the turnover of CYP2E1, differentiating the degradation of CYP2E1 from other substrates for proteasome-dependent degradation.	monorden	80-89	heat shock protein 90 alpha family class A member 1	Homo sapiens	33-38
15117720-3	2004	In an attempt to increase the HSPs in cardiac tissue, we used the compound radicicol that activates HSP expression by binding to the HSP 90 kDa (HSP90).	monorden	75-84	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	133-143
15117720-3	2004	In an attempt to increase the HSPs in cardiac tissue, we used the compound radicicol that activates HSP expression by binding to the HSP 90 kDa (HSP90).	monorden	75-84	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	145-150
15117720-7	2004	We also show that radicicol induction of the HSP and cardioprotection is dependent on the inhibition of HSP90 in cardiomyocytes.	monorden	18-27	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	104-109
15117720-9	2004	Therefore, compounds, such as radicicol and its possible derivatives that inhibit the function of HSP90 in the cell may represent potentially useful cardioprotective agents.	monorden	30-39	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	98-103
15265741-2	2004	The natural products geldanamycin (GM) and radicicol (RD) are known inhibitors of Hsp90, and their derivatives are being developed for the treatment of various cancers.	monorden	43-52	heat shock protein 90 alpha family class A member 1	Homo sapiens	82-87
15239664-2	2004	Inhibition of the ATPase activity of Hsp90 by natural products (e.g., 17-allylaminogeldanamycin or radicicol) leads to the ubiquitination of oncogenic client proteins such as Her-2, Raf-1, and p-Akt followed by their proteasomal degradation.	monorden	99-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	175-180
15239664-2	2004	Inhibition of the ATPase activity of Hsp90 by natural products (e.g., 17-allylaminogeldanamycin or radicicol) leads to the ubiquitination of oncogenic client proteins such as Her-2, Raf-1, and p-Akt followed by their proteasomal degradation.	monorden	99-108	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	182-187
15236592-6	2004	We report that apo-GRP94 undergoes a time- and temperature-dependent tertiary conformational change that exposes a site(s) of protein-protein interaction; ATP, ADP, and radicicol markedly suppress this conformational change.	monorden	169-178	heat shock protein 90 beta family member 1	Homo sapiens	19-24
15271357-5	2004	In support of this model, we show that radicicol binds equally well to both wild-type HSP90 and the Ser113 mutant, whereas the binding of GA to the Ser113 mutant is decreased significantly from its binding to wild-type HSP90.	monorden	39-48	heat shock protein 90 alpha family class A member 1	Homo sapiens	86-91
15077173-3	2004	Inhibition by the Hsp90 ATPase inhibitors, geldanamycin (GA) and radicicol (RC), revealed that Hsp90 controls IKKs at two levels, inducibility of enzymatic activity and biogenesis, which can be discriminated by short- and long-time GA incubation, respectively.	monorden	65-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	18-23
15077173-3	2004	Inhibition by the Hsp90 ATPase inhibitors, geldanamycin (GA) and radicicol (RC), revealed that Hsp90 controls IKKs at two levels, inducibility of enzymatic activity and biogenesis, which can be discriminated by short- and long-time GA incubation, respectively.	monorden	65-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	95-100
15360086-0	2004	Radicicol potentiates heat-induced cell killing in a human oesophageal cancer cell line: the Hsp90 chaperone complex as a new molecular target for enhancement of thermosensitivity.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	93-98
15360086-1	2004	PURPOSE: To examine the ability of a heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, to modify thermal response and heat-induced cell killing, and to clarify the underlining mechanisms.	monorden	96-105	heat shock protein 90 alpha family class A member 1	Homo sapiens	37-58
15360086-1	2004	PURPOSE: To examine the ability of a heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, to modify thermal response and heat-induced cell killing, and to clarify the underlining mechanisms.	monorden	96-105	heat shock protein 90 alpha family class A member 1	Homo sapiens	60-65
15360086-5	2004	RESULTS: Radicicol in combination with heat synergistically potentiated heat-induced cellular killing despite an increase in the expression of Hsp72 and Hsp27 caused by radicicol.	monorden	9-18	heat shock protein family A (Hsp70) member 1A	Homo sapiens	143-148
15360086-5	2004	RESULTS: Radicicol in combination with heat synergistically potentiated heat-induced cellular killing despite an increase in the expression of Hsp72 and Hsp27 caused by radicicol.	monorden	9-18	heat shock protein family B (small) member 1	Homo sapiens	153-158
15360086-5	2004	RESULTS: Radicicol in combination with heat synergistically potentiated heat-induced cellular killing despite an increase in the expression of Hsp72 and Hsp27 caused by radicicol.	monorden	169-178	heat shock protein family A (Hsp70) member 1A	Homo sapiens	143-148
15360086-5	2004	RESULTS: Radicicol in combination with heat synergistically potentiated heat-induced cellular killing despite an increase in the expression of Hsp72 and Hsp27 caused by radicicol.	monorden	169-178	heat shock protein family B (small) member 1	Homo sapiens	153-158
15360086-6	2004	Heat alone activated Raf-1 and p42/p44 extracellular signal-regulated kinase (Erk), and heat in combination with radicicol inhibited the activation of Raf-1 and p42/p44 Erk through reduced binding of Raf-1 to Hsp90.	monorden	113-122	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	151-156
15360086-6	2004	Heat alone activated Raf-1 and p42/p44 extracellular signal-regulated kinase (Erk), and heat in combination with radicicol inhibited the activation of Raf-1 and p42/p44 Erk through reduced binding of Raf-1 to Hsp90.	monorden	113-122	cyclin dependent kinase 20	Homo sapiens	161-164
15360086-6	2004	Heat alone activated Raf-1 and p42/p44 extracellular signal-regulated kinase (Erk), and heat in combination with radicicol inhibited the activation of Raf-1 and p42/p44 Erk through reduced binding of Raf-1 to Hsp90.	monorden	113-122	mitogen-activated protein kinase 1	Homo sapiens	169-172
15360086-6	2004	Heat alone activated Raf-1 and p42/p44 extracellular signal-regulated kinase (Erk), and heat in combination with radicicol inhibited the activation of Raf-1 and p42/p44 Erk through reduced binding of Raf-1 to Hsp90.	monorden	113-122	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	151-156
15360086-6	2004	Heat alone activated Raf-1 and p42/p44 extracellular signal-regulated kinase (Erk), and heat in combination with radicicol inhibited the activation of Raf-1 and p42/p44 Erk through reduced binding of Raf-1 to Hsp90.	monorden	113-122	heat shock protein 90 alpha family class A member 1	Homo sapiens	209-214
15360086-8	2004	CONCLUSIONS: The Hsp90 chaperone complex inhibitor, radicicol, potentiated heat-induced cellular killing, and inhibition of p42/p44 Erk and Akt activation rather than modification of Hsp expression might be involved in enhancing cellular thermosensitivity.	monorden	52-61	heat shock protein 90 alpha family class A member 1	Homo sapiens	17-22
15360086-8	2004	CONCLUSIONS: The Hsp90 chaperone complex inhibitor, radicicol, potentiated heat-induced cellular killing, and inhibition of p42/p44 Erk and Akt activation rather than modification of Hsp expression might be involved in enhancing cellular thermosensitivity.	monorden	52-61	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	17-20
15212536-1	2004	A program currently ongoing in our laboratory envisions natural macrolide radicicol-based inhibitors targeting the molecular chaperone Hsp90.	monorden	74-83	heat shock protein 90 alpha family class A member 1	Homo sapiens	135-140
15004035-7	2004	By using a temperature-sensitive mutant of p53 where cytoplasmic-nuclear movement occurs by shift to permissive temperature, we show that p53 movement is impeded when p53 binding to hsp90 is inhibited by the hsp90 inhibitor radicicol.	monorden	224-233	tumor protein p53	Homo sapiens	43-46
15004035-7	2004	By using a temperature-sensitive mutant of p53 where cytoplasmic-nuclear movement occurs by shift to permissive temperature, we show that p53 movement is impeded when p53 binding to hsp90 is inhibited by the hsp90 inhibitor radicicol.	monorden	224-233	tumor protein p53	Homo sapiens	138-141
15004035-7	2004	By using a temperature-sensitive mutant of p53 where cytoplasmic-nuclear movement occurs by shift to permissive temperature, we show that p53 movement is impeded when p53 binding to hsp90 is inhibited by the hsp90 inhibitor radicicol.	monorden	224-233	tumor protein p53	Homo sapiens	138-141
15004035-7	2004	By using a temperature-sensitive mutant of p53 where cytoplasmic-nuclear movement occurs by shift to permissive temperature, we show that p53 movement is impeded when p53 binding to hsp90 is inhibited by the hsp90 inhibitor radicicol.	monorden	224-233	heat shock protein 90 alpha family class A member 1	Homo sapiens	182-187
15004035-7	2004	By using a temperature-sensitive mutant of p53 where cytoplasmic-nuclear movement occurs by shift to permissive temperature, we show that p53 movement is impeded when p53 binding to hsp90 is inhibited by the hsp90 inhibitor radicicol.	monorden	224-233	heat shock protein 90 alpha family class A member 1	Homo sapiens	208-213
14754890-3	2004	The best predicted site was on the opposite face of the beta sheet from the pan-HSP90 radicicol-binding pocket, in close proximity to a deep hydrophobic pocket.	monorden	86-95	heat shock protein 90 alpha family class A member 1	Homo sapiens	80-85
15152036-7	2004	Using the hsp90-specific inhibitors radicicol and geldanamycin, we show that hsp90 is required for the constitutive trafficking of AMPA receptors into synapses during their continuous cycling between synaptic and nonsynaptic sites.	monorden	36-45	heat shock protein 90 alpha family class A member 1	Homo sapiens	10-15
15152036-7	2004	Using the hsp90-specific inhibitors radicicol and geldanamycin, we show that hsp90 is required for the constitutive trafficking of AMPA receptors into synapses during their continuous cycling between synaptic and nonsynaptic sites.	monorden	36-45	heat shock protein 90 alpha family class A member 1	Homo sapiens	77-82
14670946-7	2004	Ligand-dependent nuclear translocation of the wild-type receptor and misfolding and aggregation of the K632A/K633A mutant are blocked by radicicol, an Hsp90 inhibitor.	monorden	137-146	heat shock protein 90 alpha family class A member 1	Homo sapiens	151-156
14967193-2	2004	Hsp90 inhibitors geldanamycin (GA) and radicicol (Rad) have been studied as anti-inflammatory agents; however, their effects on glucocorticoid-mediated anti-inflammatory mechanism are not known.	monorden	39-48	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
14967193-2	2004	Hsp90 inhibitors geldanamycin (GA) and radicicol (Rad) have been studied as anti-inflammatory agents; however, their effects on glucocorticoid-mediated anti-inflammatory mechanism are not known.	monorden	50-53	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
15051534-4	2004	Inhibitors of HSP90 ATPase activity including the benzoquinone ansamycins, geldanamycin and 17-allylamino-17-demethoxygeldanamycin, and radicicol have been described.	monorden	136-145	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	14-19
15051534-8	2004	The known HSP90 inhibitors geldanamycin and radicicol gave IC(50) values of 4.8 and 0.9 microM respectively, which compare with values found using the conventional coupled-enzyme assay.	monorden	44-53	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	10-15
12970348-5	2003	The high resolution crystal structures at 1.75-2.1 A of the N-terminal and adjacent charged domains of GRP94 in complex with N-ethylcarboxamidoadenosine, radicicol, and 2-chlorodideoxyadenosine reveals a structural mechanism for ligand discrimination among hsp90 family members.	monorden	154-163	heat shock protein 90 beta family member 1	Homo sapiens	103-108
15346879-2	2004	The present study showed that the HSP90-binding agents, geldanamycin, herbimycin A and radicicol, inhibited the murine thymocyte apoptosis induced by dexamethasone and was accompanied by the inhibition of the reduction of the mitochondrial transmembrane potential (delta psi m).	monorden	87-96	heat shock protein, 3	Mus musculus	34-39
15062560-4	2004	Hsp90 inhibitors; geldanamycin (GA) and radicicol (Rad), significantly accelerated nuclear export of GR after withdrawal of ligands including dexamethasone, corticosterone and RU486.	monorden	40-49	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
15062560-4	2004	Hsp90 inhibitors; geldanamycin (GA) and radicicol (Rad), significantly accelerated nuclear export of GR after withdrawal of ligands including dexamethasone, corticosterone and RU486.	monorden	40-49	nuclear receptor subfamily 3 group C member 1	Homo sapiens	101-103
15062560-4	2004	Hsp90 inhibitors; geldanamycin (GA) and radicicol (Rad), significantly accelerated nuclear export of GR after withdrawal of ligands including dexamethasone, corticosterone and RU486.	monorden	51-54	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
15062560-4	2004	Hsp90 inhibitors; geldanamycin (GA) and radicicol (Rad), significantly accelerated nuclear export of GR after withdrawal of ligands including dexamethasone, corticosterone and RU486.	monorden	51-54	nuclear receptor subfamily 3 group C member 1	Homo sapiens	101-103
14622256-2	2003	The antibiotics geldanamycin and radicicol act as highly selective inhibitors of in vivo Hsp90 function through their ability to bind within the ADP/ATP binding pocket of the chaperone.	monorden	33-42	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	89-94
14645686-7	2003	AhR complexes containing Hsc82 were preferentially sensitive to the effects of low concentrations of the N-terminal inhibitors radicicol and herbimycin A.	monorden	127-136	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	25-30
14529382-6	2003	The "druggability" of Hsp90 was confirmed by the discovery that the natural products geldanamycin and radicicol, which have anticancer activity, exert their biological effects by inhibiting the essential ATPase activity associated with the N-terminal domain of the protein.	monorden	102-111	heat shock protein 90 alpha family class A member 1	Homo sapiens	22-27
14529384-1	2003	The currently used Hsp90 inhibitors, geldanamycin, herbimycin A and radicicol, were isolated many years ago from Streptomyces and fungi originally for their antiprotozoal activity, herbicidal activity and antifungal activity, respectively.	monorden	68-77	heat shock protein 90 alpha family class A member 1	Homo sapiens	19-24
14529387-3	2003	In a study of mechanisms of action, it was revealed that radicicol depletes the Hsp90 client signaling molecules in cells, and thus inhibit the signal transduction pathway.	monorden	57-66	heat shock protein 90 alpha family class A member 1	Homo sapiens	80-85
14529387-4	2003	In addition, direct binding of radicicol to the N-terminal ATP/ADP binding site of Hsp90 was shown, and thus radicicol has been recognized as a structurally unique antibiotic that binds and inhibits the molecular chaperone Hsp90.	monorden	31-40	heat shock protein 90 alpha family class A member 1	Homo sapiens	83-88
14529387-4	2003	In addition, direct binding of radicicol to the N-terminal ATP/ADP binding site of Hsp90 was shown, and thus radicicol has been recognized as a structurally unique antibiotic that binds and inhibits the molecular chaperone Hsp90.	monorden	31-40	heat shock protein 90 alpha family class A member 1	Homo sapiens	223-228
14529387-4	2003	In addition, direct binding of radicicol to the N-terminal ATP/ADP binding site of Hsp90 was shown, and thus radicicol has been recognized as a structurally unique antibiotic that binds and inhibits the molecular chaperone Hsp90.	monorden	109-118	heat shock protein 90 alpha family class A member 1	Homo sapiens	83-88
14529387-4	2003	In addition, direct binding of radicicol to the N-terminal ATP/ADP binding site of Hsp90 was shown, and thus radicicol has been recognized as a structurally unique antibiotic that binds and inhibits the molecular chaperone Hsp90.	monorden	109-118	heat shock protein 90 alpha family class A member 1	Homo sapiens	223-228
14529388-3	2003	The ansamycins (geldanamycin and herbimycin) and the unrelated natural product radicicol were found to bind to the N-terminal pocket of Hsp90 and inhibit its function.	monorden	79-88	heat shock protein 90 alpha family class A member 1	Homo sapiens	136-141
14499638-4	2003	Treatments of low doses of radicicol to RAW 264.7 cells that undergo osteoclastic differentiation in the presence of RANKL enhanced the RANKL-induced gene expression of integrin beta3 without any effect on the expression of integrin alphav, which was constitutively high.	monorden	27-36	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	117-122
14499638-4	2003	Treatments of low doses of radicicol to RAW 264.7 cells that undergo osteoclastic differentiation in the presence of RANKL enhanced the RANKL-induced gene expression of integrin beta3 without any effect on the expression of integrin alphav, which was constitutively high.	monorden	27-36	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	136-141
14499638-4	2003	Treatments of low doses of radicicol to RAW 264.7 cells that undergo osteoclastic differentiation in the presence of RANKL enhanced the RANKL-induced gene expression of integrin beta3 without any effect on the expression of integrin alphav, which was constitutively high.	monorden	27-36	integrin beta 3	Mus musculus	169-183
12842893-4	2003	Inhibition of Hsp90 by geldanamycin, radicicol, cisplatin, and novobiocin induced a significant acceleration of detergent- and hypotonic shock-induced cell lysis.	monorden	37-46	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-19
12842893-5	2003	The concentration and time dependence of cell lysis acceleration was in agreement with the Hsp90 inhibition characteristics of the N-terminal inhibitors, geldanamycin and radicicol.	monorden	171-180	heat shock protein 90 alpha family class A member 1	Homo sapiens	91-96
12964162-0	2003	NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol.	monorden	120-129	heat shock protein 90 alpha family class A member 1	Homo sapiens	66-71
12441346-3	2003	Inhibition of HSP90, a chaperone for many kinases, by geldanamycin or radicicol shifted the response of L929sA cells to TNF from necrosis to apoptosis.	monorden	70-79	heat shock protein 86, pseudogene 2	Mus musculus	14-19
12678776-6	2003	Benzoquinone ansamycin binding to Hsp90 led to the identification of radicicol as an additional Hsp90 inhibitor.	monorden	69-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	34-39
12678776-6	2003	Benzoquinone ansamycin binding to Hsp90 led to the identification of radicicol as an additional Hsp90 inhibitor.	monorden	69-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	96-101
12773056-1	2003	Radicicol (1), a macrocyclic antifungal antibiotic, is the lead compound of a novel class of heat shock protein 90 (Hsp90) inhibitors that result in the inhibition or degradation of Hsp90-associated proteins, such as v-src and Raf-1 kinases.	monorden	0-9	heat shock protein, 3	Mus musculus	93-114
12773056-1	2003	Radicicol (1), a macrocyclic antifungal antibiotic, is the lead compound of a novel class of heat shock protein 90 (Hsp90) inhibitors that result in the inhibition or degradation of Hsp90-associated proteins, such as v-src and Raf-1 kinases.	monorden	0-9	heat shock protein, 3	Mus musculus	116-121
12773056-1	2003	Radicicol (1), a macrocyclic antifungal antibiotic, is the lead compound of a novel class of heat shock protein 90 (Hsp90) inhibitors that result in the inhibition or degradation of Hsp90-associated proteins, such as v-src and Raf-1 kinases.	monorden	0-9	heat shock protein, 3	Mus musculus	182-187
12773056-1	2003	Radicicol (1), a macrocyclic antifungal antibiotic, is the lead compound of a novel class of heat shock protein 90 (Hsp90) inhibitors that result in the inhibition or degradation of Hsp90-associated proteins, such as v-src and Raf-1 kinases.	monorden	0-9	v-raf-leukemia viral oncogene 1	Mus musculus	227-232
12729599-6	2003	Geldanamycin, ADP, ATP, and radicicol-all known to bind to the ATP domain of Hsp90-competed with [3H]AAG for binding to hHsp90alpha9-236, showing K(d) values in good agreement with reported values.	monorden	28-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	77-82
12820659-1	2003	In all species studied to date, the function of heat shock protein 90 (Hsp90), a ubiquitous and evolutionarily conserved molecular chaperone, is inhibited selectively by the natural product drugs geldanamycin (GA) and radicicol.	monorden	218-227	heat shock protein 90 alpha family class A member 1	Homo sapiens	48-69
12820659-1	2003	In all species studied to date, the function of heat shock protein 90 (Hsp90), a ubiquitous and evolutionarily conserved molecular chaperone, is inhibited selectively by the natural product drugs geldanamycin (GA) and radicicol.	monorden	218-227	heat shock protein 90 alpha family class A member 1	Homo sapiens	71-76
12441346-3	2003	Inhibition of HSP90, a chaperone for many kinases, by geldanamycin or radicicol shifted the response of L929sA cells to TNF from necrosis to apoptosis.	monorden	70-79	tumor necrosis factor	Mus musculus	120-123
12471035-8	2003	Geldanamycin and radicicol, two chemically unrelated inhibitors of Hsp90, decreased the expression of EGFRvIII in glioblastoma cells.	monorden	17-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	67-72
12391259-0	2002	Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol.	monorden	203-212	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-100
12391259-0	2002	Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol.	monorden	203-212	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	101-147
12391259-4	2002	Our results indicate that the 90-kDa heat-shock protein (Hsp90) inhibitor radicicol reduces the hypoxia-induced expression of both endogenous vascular endothelial growth factor (VEGF) and HRE-driven reporter plasmids.	monorden	74-83	heat shock protein 90 alpha family class A member 1	Homo sapiens	57-62
12391259-4	2002	Our results indicate that the 90-kDa heat-shock protein (Hsp90) inhibitor radicicol reduces the hypoxia-induced expression of both endogenous vascular endothelial growth factor (VEGF) and HRE-driven reporter plasmids.	monorden	74-83	vascular endothelial growth factor A	Homo sapiens	142-176
12391259-4	2002	Our results indicate that the 90-kDa heat-shock protein (Hsp90) inhibitor radicicol reduces the hypoxia-induced expression of both endogenous vascular endothelial growth factor (VEGF) and HRE-driven reporter plasmids.	monorden	74-83	vascular endothelial growth factor A	Homo sapiens	178-182
12391259-6	2002	However, this dose of radicicol significantly reduces HRE binding by the HIF-1alpha/Arnt heterodimer.	monorden	22-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83
12391259-6	2002	However, this dose of radicicol significantly reduces HRE binding by the HIF-1alpha/Arnt heterodimer.	monorden	22-31	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	84-88
12391259-7	2002	Our results, the first to show that radicicol specifically inhibits the interaction between the HIF-1alpha/Arnt heterodimer and HRE, suggest that Hsp90 modulates the conformation of the HIF-1alpha/Arnt heterodimer, making it suitable for interaction with HRE.	monorden	36-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-106
12391259-7	2002	Our results, the first to show that radicicol specifically inhibits the interaction between the HIF-1alpha/Arnt heterodimer and HRE, suggest that Hsp90 modulates the conformation of the HIF-1alpha/Arnt heterodimer, making it suitable for interaction with HRE.	monorden	36-45	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	107-111
12391259-7	2002	Our results, the first to show that radicicol specifically inhibits the interaction between the HIF-1alpha/Arnt heterodimer and HRE, suggest that Hsp90 modulates the conformation of the HIF-1alpha/Arnt heterodimer, making it suitable for interaction with HRE.	monorden	36-45	heat shock protein 90 alpha family class A member 1	Homo sapiens	146-151
12391259-7	2002	Our results, the first to show that radicicol specifically inhibits the interaction between the HIF-1alpha/Arnt heterodimer and HRE, suggest that Hsp90 modulates the conformation of the HIF-1alpha/Arnt heterodimer, making it suitable for interaction with HRE.	monorden	36-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	186-196
12391259-7	2002	Our results, the first to show that radicicol specifically inhibits the interaction between the HIF-1alpha/Arnt heterodimer and HRE, suggest that Hsp90 modulates the conformation of the HIF-1alpha/Arnt heterodimer, making it suitable for interaction with HRE.	monorden	36-45	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	197-201
12391259-8	2002	Furthermore, we demonstrate that radicicol reduces hypoxia-induced VEGF expression to decrease hypoxia-induced angiogenesis.	monorden	33-42	vascular endothelial growth factor A	Homo sapiens	67-71
12189140-0	2002	Radicicol-sensitive peptide binding to the N-terminal portion of GRP94.	monorden	0-9	heat shock protein 90 beta family member 1	Homo sapiens	65-70
12530016-7	2002	CONCLUSION: Since geldanamycin and radicicol are specific inhibitors of the ATPase in HSP90, the present result implies that ATPase activity in HSP90 plays some role in this apoptosis.	monorden	35-44	dynein axonemal heavy chain 8	Homo sapiens	76-82
12145695-4	2002	The treatment with HA or another Hsp90 inhibitor, radicicol, induced selective apoptosis in TDFLT3-transformed 32D cells (TDFLT3/32D).	monorden	50-59	heat shock protein 86, pseudogene 2	Mus musculus	33-38
12130680-0	2002	Inhibition of branched-chain alpha-keto acid dehydrogenase kinase and Sln1 yeast histidine kinase by the antifungal antibiotic radicicol.	monorden	127-136	branched chain keto acid dehydrogenase kinase	Homo sapiens	14-65
12130680-0	2002	Inhibition of branched-chain alpha-keto acid dehydrogenase kinase and Sln1 yeast histidine kinase by the antifungal antibiotic radicicol.	monorden	127-136	histidine kinase	Saccharomyces cerevisiae S288C	70-74
12130680-4	2002	The antifungal antibiotic radicicol (Monorden) has been shown to bind to the Bergerat fold of HSP90 and to inhibit its ATPase activity.	monorden	26-35	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	94-99
12130680-5	2002	The structural similarity between the Bergerat fold of HSP90 and bacterial two-component histidine kinases prompted our inquiry into whether radicicol could be a potential inhibitor of histidine kinase-like proteins.	monorden	141-150	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	55-60
12130680-7	2002	On the basis of structural homology, we tested radicicol as a potential inhibitor of Sln1 and branched-chain alpha-keto acid dehydrogenase kinase (BCKDHK) and propose a mechanism of inhibition of these kinases.	monorden	47-56	histidine kinase	Saccharomyces cerevisiae S288C	85-89
12130680-7	2002	On the basis of structural homology, we tested radicicol as a potential inhibitor of Sln1 and branched-chain alpha-keto acid dehydrogenase kinase (BCKDHK) and propose a mechanism of inhibition of these kinases.	monorden	47-56	branched chain keto acid dehydrogenase kinase	Homo sapiens	94-145
11923316-2	2002	We have discovered that inhibition of hsp90 by radicicol or geldanamycin nearly prevents the heme-mediated activation and assembly of heme-deficient apo-nNOS in insect cells.	monorden	47-56	heat shock protein 90 alpha family class A member 1	Homo sapiens	38-43
11923316-2	2002	We have discovered that inhibition of hsp90 by radicicol or geldanamycin nearly prevents the heme-mediated activation and assembly of heme-deficient apo-nNOS in insect cells.	monorden	47-56	nitric oxide synthase 1	Homo sapiens	153-157
12530016-7	2002	CONCLUSION: Since geldanamycin and radicicol are specific inhibitors of the ATPase in HSP90, the present result implies that ATPase activity in HSP90 plays some role in this apoptosis.	monorden	35-44	heat shock protein 90 alpha family class A member 1	Homo sapiens	86-91
12530016-7	2002	CONCLUSION: Since geldanamycin and radicicol are specific inhibitors of the ATPase in HSP90, the present result implies that ATPase activity in HSP90 plays some role in this apoptosis.	monorden	35-44	dynein axonemal heavy chain 8	Homo sapiens	125-131
12530016-7	2002	CONCLUSION: Since geldanamycin and radicicol are specific inhibitors of the ATPase in HSP90, the present result implies that ATPase activity in HSP90 plays some role in this apoptosis.	monorden	35-44	heat shock protein 90 alpha family class A member 1	Homo sapiens	144-149
11911945-0	2002	Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90.	monorden	0-9	estrogen receptor 1	Homo sapiens	56-73
11960322-1	2002	Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v-Src, Bcr-Abl, Raf-1, ErbB2, some growth factor receptors and steroid receptors.	monorden	36-45	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-72
11960322-1	2002	Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v-Src, Bcr-Abl, Raf-1, ErbB2, some growth factor receptors and steroid receptors.	monorden	36-45	heat shock protein 90 alpha family class A member 1	Homo sapiens	74-79
11960322-1	2002	Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v-Src, Bcr-Abl, Raf-1, ErbB2, some growth factor receptors and steroid receptors.	monorden	36-45	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	134-141
11960322-1	2002	Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v-Src, Bcr-Abl, Raf-1, ErbB2, some growth factor receptors and steroid receptors.	monorden	36-45	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	143-148
11960322-1	2002	Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v-Src, Bcr-Abl, Raf-1, ErbB2, some growth factor receptors and steroid receptors.	monorden	36-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	150-155
11779851-2	2002	Screening of drugs that could interfere with the Akt signaling pathway revealed that Hsp90 inhibitors (e.g. geldanamycin, radicicol, and its analogues) induced Akt dephosphorylation, which resulted in Akt inactivation and apoptosis of the cells.	monorden	122-131	AKT serine/threonine kinase 1	Homo sapiens	49-52
11779851-2	2002	Screening of drugs that could interfere with the Akt signaling pathway revealed that Hsp90 inhibitors (e.g. geldanamycin, radicicol, and its analogues) induced Akt dephosphorylation, which resulted in Akt inactivation and apoptosis of the cells.	monorden	122-131	heat shock protein 90 alpha family class A member 1	Homo sapiens	85-90
11779851-2	2002	Screening of drugs that could interfere with the Akt signaling pathway revealed that Hsp90 inhibitors (e.g. geldanamycin, radicicol, and its analogues) induced Akt dephosphorylation, which resulted in Akt inactivation and apoptosis of the cells.	monorden	122-131	AKT serine/threonine kinase 1	Homo sapiens	160-163
11779851-2	2002	Screening of drugs that could interfere with the Akt signaling pathway revealed that Hsp90 inhibitors (e.g. geldanamycin, radicicol, and its analogues) induced Akt dephosphorylation, which resulted in Akt inactivation and apoptosis of the cells.	monorden	122-131	AKT serine/threonine kinase 1	Homo sapiens	160-163
11867746-7	2002	Inhibitors of heat shock protein 90 (hsp90), radicicol and geldanamycin, induced degradation of p53 and suppressed p53-induced apoptosis in normal thymocytes and myeloid leukemic cells.	monorden	45-54	tumor protein p53	Homo sapiens	96-99
11867746-7	2002	Inhibitors of heat shock protein 90 (hsp90), radicicol and geldanamycin, induced degradation of p53 and suppressed p53-induced apoptosis in normal thymocytes and myeloid leukemic cells.	monorden	45-54	tumor protein p53	Homo sapiens	115-118
11911945-4	2002	Here, we report that radicicol, an Hsp90-specific inhibitor, repressed estrogen-dependent transactivation of the ER as measured by pS2 gene transcription and a reporter gene encoding an estrogen-responsive element.	monorden	21-30	heat shock protein 90 alpha family class A member 1	Homo sapiens	35-40
11911945-4	2002	Here, we report that radicicol, an Hsp90-specific inhibitor, repressed estrogen-dependent transactivation of the ER as measured by pS2 gene transcription and a reporter gene encoding an estrogen-responsive element.	monorden	21-30	estrogen receptor 1	Homo sapiens	113-115
11911945-4	2002	Here, we report that radicicol, an Hsp90-specific inhibitor, repressed estrogen-dependent transactivation of the ER as measured by pS2 gene transcription and a reporter gene encoding an estrogen-responsive element.	monorden	21-30	taste 2 receptor member 64 pseudogene	Homo sapiens	131-134
11911945-5	2002	Furthermore, we showed that radicicol induced rapid degradation of ERalpha, while the amount of ubiquitinated ERalpha was increased.	monorden	28-37	estrogen receptor 1	Homo sapiens	67-74
11911945-7	2002	These results suggest that radicicol disrupts the ER-Hsp90 heterodimeric complex, thereby generating ERalpha that is susceptible to ubiquitin/proteasome-induced degradation.	monorden	27-36	heat shock protein 90 alpha family class A member 1	Homo sapiens	53-58
11911945-7	2002	These results suggest that radicicol disrupts the ER-Hsp90 heterodimeric complex, thereby generating ERalpha that is susceptible to ubiquitin/proteasome-induced degradation.	monorden	27-36	estrogen receptor 1	Homo sapiens	101-108
11772336-3	2002	The natural product HSP90 inhibitors geldanamycin and radicicol exert their antitumour effect by inhibiting the intrinsic ATPase activity of HSP90, resulting in degradation of HSP90 client proteins via the ubiquitin proteosome pathway.	monorden	54-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	20-25
11772336-3	2002	The natural product HSP90 inhibitors geldanamycin and radicicol exert their antitumour effect by inhibiting the intrinsic ATPase activity of HSP90, resulting in degradation of HSP90 client proteins via the ubiquitin proteosome pathway.	monorden	54-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	141-146
11772336-3	2002	The natural product HSP90 inhibitors geldanamycin and radicicol exert their antitumour effect by inhibiting the intrinsic ATPase activity of HSP90, resulting in degradation of HSP90 client proteins via the ubiquitin proteosome pathway.	monorden	54-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	141-146
11562079-0	2001	Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1.	monorden	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
11749701-0	2001	A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts.	monorden	2-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-87
11749701-0	2001	A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts.	monorden	2-11	vascular endothelial growth factor A	Homo sapiens	92-126
11749701-1	2001	A novel oxime derivative of radicicol, KF58333, binds to the heat shock protein 90 (Hsp90) and destabilizes its associated signaling molecules.	monorden	28-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-82
11749701-1	2001	A novel oxime derivative of radicicol, KF58333, binds to the heat shock protein 90 (Hsp90) and destabilizes its associated signaling molecules.	monorden	28-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	84-89
11749701-7	2001	These findings indicate that the antitumor activity of this radicicol derivative may be partly mediated by decreasing VEGF secretion from tumor cells and inhibiting tumor angiogenesis.	monorden	60-69	vascular endothelial growth factor A	Homo sapiens	118-122
11707594-3	2001	Geldanamycin and radicicol, ATP-competitive inhibitors of the chaperone HSP90, also inhibit the cleavage of in vitro-synthesized NS2/3.	monorden	17-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	72-77
11707594-3	2001	Geldanamycin and radicicol, ATP-competitive inhibitors of the chaperone HSP90, also inhibit the cleavage of in vitro-synthesized NS2/3.	monorden	17-26	NS2	Homo sapiens	129-134
11553639-9	2001	Inhibition of Hsp90 activity with geldanamycin or radicicol resulted in rapid degradation of newly synthesized GERp95.	monorden	50-59	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	14-19
11553639-9	2001	Inhibition of Hsp90 activity with geldanamycin or radicicol resulted in rapid degradation of newly synthesized GERp95.	monorden	50-59	argonaute RISC catalytic component 2	Rattus norvegicus	111-117
11686693-1	2001	Radicicol (1) exhibits potent anticancer properties in vitro, which are likely to be mediated through its high affinity (20 nM) for the molecular chaperone Hsp90.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	156-161
11714635-0	2001	Radicicol suppresses transformation and restores tropomyosin-2 expression in both ras- and MEK-transformed cells without inhibiting the Raf/MEK/ERK signaling cascade.	monorden	0-9	mitogen-activated protein kinase kinase 7	Homo sapiens	91-94
11714635-3	2001	Here we demonstrate that radicicol induces cell spreading, suppresses anchorage-independent cell growth, and increases the expression of the high-molecular weight tropomyosin isoform TM-2 in cells stably expressing a constitutively active form of MEK-1 as well as in ras-transformed cells.	monorden	25-34	mitogen-activated protein kinase kinase 1	Homo sapiens	247-252
11714635-5	2001	In contrast, low concentrations of radicicol significantly inhibited activator protein (AP-1) and serum response factor (SRF)-mediated transcription.	monorden	35-44	serum response factor	Homo sapiens	98-119
11714635-5	2001	In contrast, low concentrations of radicicol significantly inhibited activator protein (AP-1) and serum response factor (SRF)-mediated transcription.	monorden	35-44	serum response factor	Homo sapiens	121-124
11714635-7	2001	Our observation that low concentrations of radicicol block transcriptional activities mediated by AP-1 and SRF suggests that interference with signaling upstream of these transcription factors may contribute to the reverting effects of the drug.	monorden	43-52	serum response factor	Homo sapiens	107-110
11500428-3	2001	Pretreatment with any of the three Hsp90 inhibitors geldanamycin, radicicol, and herbimycin A resulted in a dose-dependent suppression of cytokine production from the spleen cells and macrophages and of NO from macrophages stimulated with CpG ODN or E. coli DNA.	monorden	66-75	heat shock protein, 2	Mus musculus	35-40
11562079-6	2001	Treatment of radicicol to THP-1 cells produced a strong inhibition of NF-KB and AP-1, while NF-IL6 was not significantly affected by radicicol.	monorden	13-22	GLI family zinc finger 2	Homo sapiens	26-31
11562079-6	2001	Treatment of radicicol to THP-1 cells produced a strong inhibition of NF-KB and AP-1, while NF-IL6 was not significantly affected by radicicol.	monorden	13-22	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-84
11562079-7	2001	Western blot analysis showed that radicicol inhibited the phosphorylation and phosphotransferase activities of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38.	monorden	34-43	mitogen-activated protein kinase 1	Homo sapiens	111-157
11562079-7	2001	Western blot analysis showed that radicicol inhibited the phosphorylation and phosphotransferase activities of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38.	monorden	34-43	mitogen-activated protein kinase 3	Homo sapiens	159-165
11562079-7	2001	Western blot analysis showed that radicicol inhibited the phosphorylation and phosphotransferase activities of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38.	monorden	34-43	mitogen-activated protein kinase 1	Homo sapiens	171-174
11562079-9	2001	Collectively, this series of experiments indicates that radicicol inhibits IL-8 gene expression by blocking ERK1/2 and p38 signaling.	monorden	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
11562079-9	2001	Collectively, this series of experiments indicates that radicicol inhibits IL-8 gene expression by blocking ERK1/2 and p38 signaling.	monorden	56-65	mitogen-activated protein kinase 3	Homo sapiens	108-114
11562079-9	2001	Collectively, this series of experiments indicates that radicicol inhibits IL-8 gene expression by blocking ERK1/2 and p38 signaling.	monorden	56-65	mitogen-activated protein kinase 1	Homo sapiens	119-122
11730806-9	2001	The protein kinase C inhibitor Ro 31-8220 (0.1 microM), the Raf-1 inhibitor radicicol (10 microM), and the MAPK kinase inhibitor PD 098059 (10 microM) abolished mitogenic effects of Ang II and 5-HT, and also their synergistic interaction.	monorden	76-85	RAF proto-oncogene serine/threonine-protein kinase	Oryctolagus cuniculus	60-65
11730806-9	2001	The protein kinase C inhibitor Ro 31-8220 (0.1 microM), the Raf-1 inhibitor radicicol (10 microM), and the MAPK kinase inhibitor PD 098059 (10 microM) abolished mitogenic effects of Ang II and 5-HT, and also their synergistic interaction.	monorden	76-85	angiogenin	Oryctolagus cuniculus	182-185
11800023-1	2001	PURPOSE: Radicicol is a novel hsp90 antagonist, distinct from the chemically unrelated benzoquinone ansamycin compounds, geldanamycin and herbimycin.	monorden	9-18	heat shock protein 90 alpha family class A member 1	Homo sapiens	30-35
11800023-2	2001	Both geldanamycin and radicicol bind in the aminoterminal nucleotide-binding pocket of hsp90, destabilizing the hsp90 client proteins, many of which are essential for tumor cell growth.	monorden	22-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	87-92
11800023-2	2001	Both geldanamycin and radicicol bind in the aminoterminal nucleotide-binding pocket of hsp90, destabilizing the hsp90 client proteins, many of which are essential for tumor cell growth.	monorden	22-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	112-117
11800023-7	2001	Direct binding activity to hsp90 was assessed by hsp90-binding assays using geldanamycin or radicicol beads.	monorden	92-101	heat shock protein 90 alpha family class A member 1	Homo sapiens	27-32
11800023-7	2001	Direct binding activity to hsp90 was assessed by hsp90-binding assays using geldanamycin or radicicol beads.	monorden	92-101	heat shock protein 90 alpha family class A member 1	Homo sapiens	49-54
11562079-0	2001	Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1.	monorden	39-48	mitogen-activated protein kinase 3	Homo sapiens	87-93
11562079-0	2001	Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1.	monorden	39-48	mitogen-activated protein kinase 1	Homo sapiens	98-101
11562079-0	2001	Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1.	monorden	39-48	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	153-157
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	monorden	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	monorden	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	monorden	13-22	GLI family zinc finger 2	Homo sapiens	114-119
11473354-7	2001	Natural inhibitors of the ATPase activity, like geldanamycin and radicicol, block the processing of Hsp90 substrate proteins.	monorden	65-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	100-105
11360191-7	2001	In addition, UCS15A appeared to differ from src-destabilizing agents such as herbimycin and radicicol that destabilize src by interfering with Hsp90.	monorden	92-101	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	119-122
11448926-5	2001	We found that interaction of the Hsp90-binding drugs geldanamycin and radicicol with the chaperone destabilizes these hormone receptors in a ligand-independent manner, leading to profound and prolonged depletion of their levels in breast cancer cells cultured in vitro.	monorden	70-79	heat shock protein 90 alpha family class A member 1	Homo sapiens	33-38
11267999-4	2001	Accordingly, ERK1/2 phosphorylation induced by UTP was inhibited by the PI3K inhibitors, wortmannin and LY294002, and the c-src inhibitors, radicicol and PP2, but not by inhibitors of protein kinase C (PKC).	monorden	140-149	mitogen-activated protein kinase 3	Homo sapiens	13-19
11587362-9	2001	Another HSP90 inhibitor, radicicol, also induced apoptosis selectively in transformed 32D cells.	monorden	25-34	heat shock protein 86, pseudogene 2	Mus musculus	8-13
11447118-7	2001	A short-term exposure of cells to the Hsp90 inhibitors GA or radicicol not only derepresses PKR, but also activates the Raf-MAPK pathway.	monorden	61-70	heat shock protein 90 alpha family class A member 1	Homo sapiens	38-43
11447118-7	2001	A short-term exposure of cells to the Hsp90 inhibitors GA or radicicol not only derepresses PKR, but also activates the Raf-MAPK pathway.	monorden	61-70	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	92-95
11360191-7	2001	In addition, UCS15A appeared to differ from src-destabilizing agents such as herbimycin and radicicol that destabilize src by interfering with Hsp90.	monorden	92-101	heat shock protein 90 alpha family class A member 1	Homo sapiens	143-148
10955818-2	2000	Over the past 5 years, the antitumor antibiotics geldanamycin and radicicol have become recognized as selective Hsp90-binding agents (HBA) with a novel ability to alter the activity of many of the receptors, kinases, and transcription factors involved in these cancer-associated pathways.	monorden	66-75	heat shock protein, 3	Mus musculus	112-117
11347901-0	2001	Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins.	monorden	57-66	nuclear receptor subfamily 3 group C member 1	Homo sapiens	30-53
11347901-1	2001	Radicicol (RAD) and the benzoquinone ansamycin geldanamycin (GA) are potential anticancer drugs known to inhibit heat shock protein 90 (hsp90) and, therefore, the activation of proteins dependent on its function such as proto-oncogenic kinases and nuclear receptors.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	113-134
11347901-1	2001	Radicicol (RAD) and the benzoquinone ansamycin geldanamycin (GA) are potential anticancer drugs known to inhibit heat shock protein 90 (hsp90) and, therefore, the activation of proteins dependent on its function such as proto-oncogenic kinases and nuclear receptors.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	136-141
11306353-2	2001	Occupancy of this pocket by several natural products (geldanamycin (GM) and radicicol) alters Hsp90 function and results in the degradation of a subset of proteins (i.e. steroid receptors, Her2, Raf).	monorden	76-85	heat shock protein 90 alpha family class A member 1	Homo sapiens	94-99
11306353-2	2001	Occupancy of this pocket by several natural products (geldanamycin (GM) and radicicol) alters Hsp90 function and results in the degradation of a subset of proteins (i.e. steroid receptors, Her2, Raf).	monorden	76-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	189-193
11306353-2	2001	Occupancy of this pocket by several natural products (geldanamycin (GM) and radicicol) alters Hsp90 function and results in the degradation of a subset of proteins (i.e. steroid receptors, Her2, Raf).	monorden	76-85	zinc fingers and homeoboxes 2	Homo sapiens	195-198
10979978-0	2000	Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex.	monorden	27-36	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	193-200
10979978-0	2000	Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex.	monorden	27-36	heat shock protein 90 alpha family class A member 1	Homo sapiens	206-211
10979978-2	2000	Radicicol, a macrocyclic antifungal antibiotic, binds to the N-terminal of heat shock protein 90 (Hsp90) and destabilizes Hsp90-associated proteins such as Raf-1.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	75-96
10979978-2	2000	Radicicol, a macrocyclic antifungal antibiotic, binds to the N-terminal of heat shock protein 90 (Hsp90) and destabilizes Hsp90-associated proteins such as Raf-1.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	98-103
10979978-2	2000	Radicicol, a macrocyclic antifungal antibiotic, binds to the N-terminal of heat shock protein 90 (Hsp90) and destabilizes Hsp90-associated proteins such as Raf-1.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	122-127
10979978-2	2000	Radicicol, a macrocyclic antifungal antibiotic, binds to the N-terminal of heat shock protein 90 (Hsp90) and destabilizes Hsp90-associated proteins such as Raf-1.	monorden	0-9	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	156-161
11007781-0	2000	Radicicol binds and inhibits mammalian ATP citrate lyase.	monorden	0-9	ATP citrate lyase	Homo sapiens	39-56
11007781-7	2000	Interaction between BR-1 and ATP citrate lyase was blocked by radicicol but not by herbimycin A that interacts with Hsp90.	monorden	62-71	C-X-C motif chemokine ligand 11	Homo sapiens	20-24
11007781-7	2000	Interaction between BR-1 and ATP citrate lyase was blocked by radicicol but not by herbimycin A that interacts with Hsp90.	monorden	62-71	ATP citrate lyase	Homo sapiens	29-46
11007781-10	2000	The activity of rat liver ATP citrate lyase was inhibited by radicicol and BR-1 but not by BR-6.	monorden	61-70	ATP citrate lyase	Rattus norvegicus	26-43
11007781-11	2000	Kinetic analysis demonstrated that radicicol was a non-competitive inhibitor of ATP citrate lyase with K(i) values for citrate and ATP of 13 and 7 microm, respectively.	monorden	35-44	ATP citrate lyase	Homo sapiens	80-97
10945979-3	2000	The anti-tumor agents geldanamycin and radicicol bind specifically at this site and induce destabilization of Hsp90-dependent client proteins.	monorden	39-48	heat shock protein 90 alpha family class A member 1	Homo sapiens	110-115
10945979-4	2000	We recently demonstrated that the gyrase inhibitor novobiocin also interacts with Hsp90, altering the affinity of the chaperone for geldanamycin and radicicol and causing in vitro and in vivo depletion of key regulatory Hsp90-dependent kinases including v-Src, Raf-1, and p185(ErbB2).	monorden	149-158	heat shock protein 90 alpha family class A member 1	Homo sapiens	82-87
10900231-0	2000	Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages.	monorden	0-9	nitric oxide synthase 2	Homo sapiens	35-66
10900231-0	2000	Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages.	monorden	0-9	mitogen-activated protein kinase 14	Homo sapiens	79-82
10900231-1	2000	We show that radicicol, a fungal antibiotic, produces a marked inhibition of p38 kinase, nuclear factor-kappaB/Rel (NF-kappaB/Rel), and inducible nitric-oxide synthase (iNOS) transcription by the macrophage line RAW 264.7 in response to lipopolysaccharide (LPS).	monorden	13-22	nuclear factor kappa B subunit 1	Homo sapiens	77-125
10900231-1	2000	We show that radicicol, a fungal antibiotic, produces a marked inhibition of p38 kinase, nuclear factor-kappaB/Rel (NF-kappaB/Rel), and inducible nitric-oxide synthase (iNOS) transcription by the macrophage line RAW 264.7 in response to lipopolysaccharide (LPS).	monorden	13-22	nitric oxide synthase 2	Homo sapiens	136-167
10900231-1	2000	We show that radicicol, a fungal antibiotic, produces a marked inhibition of p38 kinase, nuclear factor-kappaB/Rel (NF-kappaB/Rel), and inducible nitric-oxide synthase (iNOS) transcription by the macrophage line RAW 264.7 in response to lipopolysaccharide (LPS).	monorden	13-22	nitric oxide synthase 2	Homo sapiens	169-173
10900231-2	2000	Treatment of RAW 264.7 with radicicol inhibited LPS-stimulated p38 kinase phosphorylation in a dose-related manner.	monorden	28-37	mitogen-activated protein kinase 14	Homo sapiens	63-66
10900231-6	2000	LPS-induced loss of inhibitory proteins IkappaB-alpha and IkappaB-beta and translocation of p65, c-Rel, and p50 was inhibited by radicicol.	monorden	129-138	NFKB inhibitor alpha	Homo sapiens	40-53
10900231-6	2000	LPS-induced loss of inhibitory proteins IkappaB-alpha and IkappaB-beta and translocation of p65, c-Rel, and p50 was inhibited by radicicol.	monorden	129-138	NFKB inhibitor beta	Homo sapiens	58-70
10900231-6	2000	LPS-induced loss of inhibitory proteins IkappaB-alpha and IkappaB-beta and translocation of p65, c-Rel, and p50 was inhibited by radicicol.	monorden	129-138	RELA proto-oncogene, NF-kB subunit	Homo sapiens	92-95
10900231-6	2000	LPS-induced loss of inhibitory proteins IkappaB-alpha and IkappaB-beta and translocation of p65, c-Rel, and p50 was inhibited by radicicol.	monorden	129-138	REL proto-oncogene, NF-kB subunit	Homo sapiens	97-102
10900231-6	2000	LPS-induced loss of inhibitory proteins IkappaB-alpha and IkappaB-beta and translocation of p65, c-Rel, and p50 was inhibited by radicicol.	monorden	129-138	nuclear factor kappa B subunit 1	Homo sapiens	108-111
10900231-7	2000	Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking p38 kinase signaling.	monorden	56-65	nitric oxide synthase 2	Homo sapiens	75-79
10900231-7	2000	Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking p38 kinase signaling.	monorden	56-65	mitogen-activated protein kinase 14	Homo sapiens	108-111
10900231-8	2000	Due to the critical role that NO release plays in mediating inflammatory responses, the inhibitory effects of radicicol on iNOS suggest that this potent antifungal agent may represent a useful anti-inflammatory agent.	monorden	110-119	nitric oxide synthase 2	Homo sapiens	123-127
10816560-7	2000	bis-ANS activation of GRP94 function was efficiently blocked by radicicol, an established inhibitory ligand for the adenosine nucleotide binding pocket.	monorden	64-73	heat shock protein 90 beta family member 1	Homo sapiens	22-27
10816561-6	2000	NECA binding to GRP94 was efficiently blocked by geldanamycin and radicicol.	monorden	66-75	heat shock protein 90 beta family member 1	Homo sapiens	16-21
10816561-8	2000	In contrast, GRP94 bound radicicol at a stoichiometry of 2 mol of radicicol/mol of GRP94 dimer.	monorden	25-34	heat shock protein 90 beta family member 1	Homo sapiens	13-18
10816561-8	2000	In contrast, GRP94 bound radicicol at a stoichiometry of 2 mol of radicicol/mol of GRP94 dimer.	monorden	25-34	heat shock protein 90 beta family member 1	Homo sapiens	83-88
11005382-13	2000	Treatment of Hepa-1 cells with the hsp90-binding benzoquinone ansamycin, geldanamycin, and the macrocyclic antifungal compound radicicol resulted in AhR but not XAP2 or FKBP52 turnover.	monorden	127-136	aryl-hydrocarbon receptor	Mus musculus	149-152
10816560-3	2000	The N-terminal domain of eukaryotic Hsp90 proteins contains a conserved adenosine nucleotide binding pocket that also serves as the binding site for the Hsp90 inhibitors geldanamycin and radicicol.	monorden	187-196	heat shock protein 90 alpha family class A member 1	Homo sapiens	36-41
10816560-3	2000	The N-terminal domain of eukaryotic Hsp90 proteins contains a conserved adenosine nucleotide binding pocket that also serves as the binding site for the Hsp90 inhibitors geldanamycin and radicicol.	monorden	187-196	heat shock protein 90 alpha family class A member 1	Homo sapiens	153-158
11005382-13	2000	Treatment of Hepa-1 cells with the hsp90-binding benzoquinone ansamycin, geldanamycin, and the macrocyclic antifungal compound radicicol resulted in AhR but not XAP2 or FKBP52 turnover.	monorden	127-136	aryl-hydrocarbon receptor-interacting protein	Mus musculus	161-165
11005382-13	2000	Treatment of Hepa-1 cells with the hsp90-binding benzoquinone ansamycin, geldanamycin, and the macrocyclic antifungal compound radicicol resulted in AhR but not XAP2 or FKBP52 turnover.	monorden	127-136	FK506 binding protein 4	Mus musculus	169-175
10793137-4	2000	Using specific inhibitors of Hsp90, geldanamycin and radicicol, we found that functional Hsp90 is essential for the stability of newly synthesized, but not mature, Lck.	monorden	53-62	heat shock protein 90 alpha family class A member 1	Homo sapiens	89-94
10655441-2	2000	Two unrelated antibiotics, geldanamycin and radicicol, bind specifically to an atypical nucleotide-binding pocket of Hsp90, a site that shares homology with the adenosine triphosphate (ATP)-binding domain of bacterial DNA gyrase B.	monorden	44-53	heat shock protein, 2	Mus musculus	117-122
10652318-9	2000	In addition, TRAP1 exhibited ATPase activity that was inhibited by both geldanamycin and radicicol.	monorden	89-98	TNF receptor associated protein 1	Homo sapiens	13-18
10092503-0	1999	A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner.	monorden	2-11	mitogen-activated protein kinase 14	Homo sapiens	93-96
10478836-2	1999	Radicicol, an antifungal antibiotic that inhibits various signal transduction proteins such as v-src, ras, Raf-1, and mos, was found to bind to Hsp90, thus making it the prototype of a second class of Hsp90 inhibitors, distinct from the chemically unrelated benzoquinone ansamycins.	monorden	0-9	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	107-112
10478836-2	1999	Radicicol, an antifungal antibiotic that inhibits various signal transduction proteins such as v-src, ras, Raf-1, and mos, was found to bind to Hsp90, thus making it the prototype of a second class of Hsp90 inhibitors, distinct from the chemically unrelated benzoquinone ansamycins.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	144-149
10478836-2	1999	Radicicol, an antifungal antibiotic that inhibits various signal transduction proteins such as v-src, ras, Raf-1, and mos, was found to bind to Hsp90, thus making it the prototype of a second class of Hsp90 inhibitors, distinct from the chemically unrelated benzoquinone ansamycins.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	201-206
10478836-6	1999	Radicicol binds more strongly to Hsp90 than to Grp94, the Hsp90 homolog that resides in the endoplasmic reticulum.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	33-38
10478836-6	1999	Radicicol binds more strongly to Hsp90 than to Grp94, the Hsp90 homolog that resides in the endoplasmic reticulum.	monorden	0-9	heat shock protein 90 beta family member 1	Homo sapiens	47-52
10478836-6	1999	Radicicol binds more strongly to Hsp90 than to Grp94, the Hsp90 homolog that resides in the endoplasmic reticulum.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	58-63
10478836-7	1999	In contrast to Hsp90, binding of radicicol to Grp94 requires both the N-terminal ATP/ADP-binding domain as well as the adjacent negatively charged region.	monorden	33-42	heat shock protein 90 beta family member 1	Homo sapiens	46-51
10478836-9	1999	Thus, the radicicol-binding site appears to be specific to and is conserved in all members of the Hsp90 family of molecular chaperones from bacteria to mammals, but is not present in other molecular chaperones with nucleotide-binding domains.	monorden	10-19	heat shock protein 90 alpha family class A member 1	Homo sapiens	98-103
10383157-0	1999	KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.	monorden	37-46	heat shock protein 90 alpha family class A member 1	Homo sapiens	111-116
10383157-1	1999	Radicicol, a macrocyclic antifungal antibiotic, has been shown to bind to the heat shock protein 90 (Hsp90) chaperone, interfering with its function.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	78-99
10383157-1	1999	Radicicol, a macrocyclic antifungal antibiotic, has been shown to bind to the heat shock protein 90 (Hsp90) chaperone, interfering with its function.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	101-106
15687592-1	2000	Several natural product antibiotics, including herbimycin, geldanamycin, and radicicol, bind to an amino terminal nucleotide binding pocket in the heat shock protein Hsp90.	monorden	77-86	heat shock protein 90 alpha family class A member 1	Homo sapiens	166-171
10092503-6	1999	Recently, radicicol was reported as an inhibitor of activated-Ras-induced ERK activation.	monorden	10-19	mitogen-activated protein kinase 1	Homo sapiens	74-77
9672245-0	1998	Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.	monorden	11-20	heat shock protein 90 alpha family class A member 1	Homo sapiens	55-60
9925731-0	1999	Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.	monorden	94-103	heat shock protein 90 alpha family class A member 1	Homo sapiens	39-44
9925731-1	1999	The cellular activity of several regulatory and signal transduction proteins, which depend on the Hsp90 molecular chaperone for folding, is markedly decreased by geldanamycin and by radicicol (monorden).	monorden	182-191	heat shock protein 90 alpha family class A member 1	Homo sapiens	98-103
9925731-2	1999	We now show that these unrelated compounds both bind to the N-terminal ATP/ADP-binding domain of Hsp90, with radicicol displaying nanomolar affinity, and both inhibit the inherent ATPase activity of Hsp90 which is essential for its function in vivo.	monorden	109-118	heat shock protein 90 alpha family class A member 1	Homo sapiens	97-102
9925731-2	1999	We now show that these unrelated compounds both bind to the N-terminal ATP/ADP-binding domain of Hsp90, with radicicol displaying nanomolar affinity, and both inhibit the inherent ATPase activity of Hsp90 which is essential for its function in vivo.	monorden	109-118	heat shock protein 90 alpha family class A member 1	Homo sapiens	199-204
9925731-3	1999	Crystal structure determinations of Hsp90 N-terminal domain complexes with geldanamycin and radicicol identify key aspects of their nucleotide mimicry and suggest a rational basis for the design of novel antichaperone drugs.	monorden	92-101	heat shock protein 90 alpha family class A member 1	Homo sapiens	36-41
9579582-4	1998	Pretreatment of cells with Src or the Src-like PTK inhibitor herbimycin A or radicicol, alleviated dose-dependently the growth-inhibitory activity of IFN-alpha2a against v-src-transformed cells, suggesting that IFNs may share a common inhibitory pathway with Src PTK inhibitors.	monorden	77-86	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	38-41
9579582-4	1998	Pretreatment of cells with Src or the Src-like PTK inhibitor herbimycin A or radicicol, alleviated dose-dependently the growth-inhibitory activity of IFN-alpha2a against v-src-transformed cells, suggesting that IFNs may share a common inhibitory pathway with Src PTK inhibitors.	monorden	77-86	interferon alpha 2	Homo sapiens	150-160
9579582-4	1998	Pretreatment of cells with Src or the Src-like PTK inhibitor herbimycin A or radicicol, alleviated dose-dependently the growth-inhibitory activity of IFN-alpha2a against v-src-transformed cells, suggesting that IFNs may share a common inhibitory pathway with Src PTK inhibitors.	monorden	77-86	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	172-175
9579582-4	1998	Pretreatment of cells with Src or the Src-like PTK inhibitor herbimycin A or radicicol, alleviated dose-dependently the growth-inhibitory activity of IFN-alpha2a against v-src-transformed cells, suggesting that IFNs may share a common inhibitory pathway with Src PTK inhibitors.	monorden	77-86	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	38-41
9632140-0	1998	Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol.	monorden	84-93	heat shock protein 86, pseudogene 1	Mus musculus	36-41
9632140-6	1998	This was confirmed by demonstrating the ability of radicicol to specifically bind purified human HSP90.	monorden	51-60	heat shock protein 90 alpha family class A member 1	Homo sapiens	97-102
9632140-8	1998	Taken together with other studies the present observations suggest that the anti-transformation effects of radicicol may be mediated, at least in part, by the association of radicicol with HSP90 and the consequent dissociation of the Raf/HSP90 complex leading to the attenuation of the Ras/MAP kinase signal transduction pathway.	monorden	107-116	heat shock protein 86, pseudogene 1	Mus musculus	189-194
9632140-8	1998	Taken together with other studies the present observations suggest that the anti-transformation effects of radicicol may be mediated, at least in part, by the association of radicicol with HSP90 and the consequent dissociation of the Raf/HSP90 complex leading to the attenuation of the Ras/MAP kinase signal transduction pathway.	monorden	107-116	heat shock protein 86, pseudogene 1	Mus musculus	238-243
9632140-8	1998	Taken together with other studies the present observations suggest that the anti-transformation effects of radicicol may be mediated, at least in part, by the association of radicicol with HSP90 and the consequent dissociation of the Raf/HSP90 complex leading to the attenuation of the Ras/MAP kinase signal transduction pathway.	monorden	174-183	heat shock protein 86, pseudogene 1	Mus musculus	189-194
10048975-7	1999	CDDP resistance in v-src-transfected cells was reversed, if not completely, by either herbimycin A or radicicol, specific inhibitors of Src-family PTKs, suggesting that Src tyrosine kinase activity induces CDDP resistance.	monorden	102-111	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	21-24
10048975-7	1999	CDDP resistance in v-src-transfected cells was reversed, if not completely, by either herbimycin A or radicicol, specific inhibitors of Src-family PTKs, suggesting that Src tyrosine kinase activity induces CDDP resistance.	monorden	102-111	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	136-139
10048975-7	1999	CDDP resistance in v-src-transfected cells was reversed, if not completely, by either herbimycin A or radicicol, specific inhibitors of Src-family PTKs, suggesting that Src tyrosine kinase activity induces CDDP resistance.	monorden	102-111	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	169-172
9651388-9	1998	The radicicol analog itself did not inhibit ICE, but markedly, and very rapidly depleted intracellular levels of 31-kDa proIL-1beta.	monorden	4-13	interleukin 1 beta	Homo sapiens	120-131
9672245-3	1998	We now show that radicicol, a macrocyclic antifungal structurally unrelated to geldanamycin, also specifically binds to Hsp90.	monorden	17-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	120-125
9672245-5	1998	Radicicol, as does geldanamycin, also inhibits the binding of the accessory protein p23 to Hsp90, and interferes with assembly of the mature progesterone receptor complex.	monorden	0-9	prostaglandin E synthase 3	Homo sapiens	84-87
9672245-5	1998	Radicicol, as does geldanamycin, also inhibits the binding of the accessory protein p23 to Hsp90, and interferes with assembly of the mature progesterone receptor complex.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	91-96
9672245-6	1998	Radicicol does not deplete cells of Hsp90, but rather increases synthesis as well as the steady-state level of this protein, similar to a stress response.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	36-41
9672245-7	1998	Finally, radicicol depletes SKBR3 cells of p185erbB2, Raf-1 and mutant p53, similar to geldanamycin.	monorden	9-18	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-52
9672245-7	1998	Finally, radicicol depletes SKBR3 cells of p185erbB2, Raf-1 and mutant p53, similar to geldanamycin.	monorden	9-18	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	54-59
9672245-7	1998	Finally, radicicol depletes SKBR3 cells of p185erbB2, Raf-1 and mutant p53, similar to geldanamycin.	monorden	9-18	tumor protein p53	Homo sapiens	71-74
9672245-8	1998	Radicicol thus represents a structurally unique antibiotic, and the first non-benzoquinone ansamycin, capable of binding to Hsp90 and interfering with its function.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	124-129
8980876-1	1996	A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) secretion from THP-1 cells.	monorden	2-11	interleukin 1 beta	Homo sapiens	55-73
9422737-3	1998	Radicicol, an antifungal antibiotic, was found to inhibit the K-ras signaling pathway reconstituted in yeast.	monorden	0-9	KRAS proto-oncogene, GTPase	Rattus norvegicus	62-67
9422737-4	1998	In K-ras-transformed, rat epithelial, and K-ras-activated, human pancreatic carcinoma cell lines, radicicol inhibited K-Ras-induced hyperphosphorylation of Erk2.	monorden	98-107	KRAS proto-oncogene, GTPase	Rattus norvegicus	3-8
9422737-4	1998	In K-ras-transformed, rat epithelial, and K-ras-activated, human pancreatic carcinoma cell lines, radicicol inhibited K-Ras-induced hyperphosphorylation of Erk2.	monorden	98-107	KRAS proto-oncogene, GTPase	Rattus norvegicus	42-47
9422737-4	1998	In K-ras-transformed, rat epithelial, and K-ras-activated, human pancreatic carcinoma cell lines, radicicol inhibited K-Ras-induced hyperphosphorylation of Erk2.	monorden	98-107	KRAS proto-oncogene, GTPase	Homo sapiens	118-123
9422737-4	1998	In K-ras-transformed, rat epithelial, and K-ras-activated, human pancreatic carcinoma cell lines, radicicol inhibited K-Ras-induced hyperphosphorylation of Erk2.	monorden	98-107	mitogen-activated protein kinase 1	Homo sapiens	156-160
9422737-6	1998	These results suggest that radicicol disrupts the K-Ras-activated signaling pathway by selectively depleting Raf kinase and raises the possibility that pharmacological destabilization of Raf kinase could be a new and powerful approach for the treatment of K-ras-activated human cancers.	monorden	27-36	KRAS proto-oncogene, GTPase	Homo sapiens	50-55
9422737-6	1998	These results suggest that radicicol disrupts the K-Ras-activated signaling pathway by selectively depleting Raf kinase and raises the possibility that pharmacological destabilization of Raf kinase could be a new and powerful approach for the treatment of K-ras-activated human cancers.	monorden	27-36	KRAS proto-oncogene, GTPase	Homo sapiens	256-261
9399650-5	1997	Screening of cellular proteins enhanced in response to radicicol by two-dimensional gel electrophoresis suggested that the amount of gelsolin, an actin regulatory protein, was distinctly increased upon radicicol treatment.	monorden	202-211	gelsolin	Homo sapiens	133-141
9399650-6	1997	Western blot and Northern blot analyses showed that radicicol enhanced transcription of the gelsolin gene in human carcinoma cell lines, as a result of which the amount of gelsolin was increased several folds.	monorden	52-61	gelsolin	Homo sapiens	92-100
9399650-6	1997	Western blot and Northern blot analyses showed that radicicol enhanced transcription of the gelsolin gene in human carcinoma cell lines, as a result of which the amount of gelsolin was increased several folds.	monorden	52-61	gelsolin	Homo sapiens	172-180
9399650-7	1997	Injection with an anti-gelsolin antibody into cells and successive treatment with radicicol resulted in approximately 80% reduction of the number of flat cells with stress fibers in comparison with controls treated with an irrelevant antibody.	monorden	82-91	gelsolin	Homo sapiens	23-31
8930398-0	1996	Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells.	monorden	0-9	Rous sarcoma oncogene	Mus musculus	59-62
8930398-0	1996	Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells.	monorden	0-9	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	73-78
8930398-0	1996	Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells.	monorden	0-9	Rous sarcoma oncogene	Mus musculus	123-126
8930398-2	1996	This study examines the effects of radicicol, a Src tyrosine kinase inhibitor, upon both the phosphorylation of Sam68 and mitotic progression in Src-transformed mouse fibroblasts.	monorden	35-44	Rous sarcoma oncogene	Mus musculus	48-51
8930398-2	1996	This study examines the effects of radicicol, a Src tyrosine kinase inhibitor, upon both the phosphorylation of Sam68 and mitotic progression in Src-transformed mouse fibroblasts.	monorden	35-44	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	112-117
8930398-2	1996	This study examines the effects of radicicol, a Src tyrosine kinase inhibitor, upon both the phosphorylation of Sam68 and mitotic progression in Src-transformed mouse fibroblasts.	monorden	35-44	Rous sarcoma oncogene	Mus musculus	145-148
8930398-3	1996	Radicicol reversibly inhibits the mitosis-specific tyrosine phosphorylation of Sam68 in vivo, as determined by antiphosphotyrosine immunoblotting.	monorden	0-9	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	79-84
8930398-4	1996	Radicicol inhibits the tyrosine phosphorylation of both free and Src-associated Sam68, suggesting the presence of two intracellular pools of tyrosine phosphorylated Sam68 in mitotic cells.	monorden	0-9	Rous sarcoma oncogene	Mus musculus	65-68
8930398-4	1996	Radicicol inhibits the tyrosine phosphorylation of both free and Src-associated Sam68, suggesting the presence of two intracellular pools of tyrosine phosphorylated Sam68 in mitotic cells.	monorden	0-9	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	80-85
8930398-4	1996	Radicicol inhibits the tyrosine phosphorylation of both free and Src-associated Sam68, suggesting the presence of two intracellular pools of tyrosine phosphorylated Sam68 in mitotic cells.	monorden	0-9	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	165-170
8930398-7	1996	Radicicol mediated inhibition of Sam68 tyrosine phosphorylation, and its concurrent ability to block mitotic exit suggests the possibility of a significant role for Src kinase and this unique mitotic substrate, Sam68, in cell cycle regulation.	monorden	0-9	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	33-38
8930398-7	1996	Radicicol mediated inhibition of Sam68 tyrosine phosphorylation, and its concurrent ability to block mitotic exit suggests the possibility of a significant role for Src kinase and this unique mitotic substrate, Sam68, in cell cycle regulation.	monorden	0-9	Rous sarcoma oncogene	Mus musculus	165-168
8930398-7	1996	Radicicol mediated inhibition of Sam68 tyrosine phosphorylation, and its concurrent ability to block mitotic exit suggests the possibility of a significant role for Src kinase and this unique mitotic substrate, Sam68, in cell cycle regulation.	monorden	0-9	KH domain containing, RNA binding, signal transduction associated 1	Mus musculus	211-216
9399650-0	1997	Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression.	monorden	47-56	gelsolin	Homo sapiens	84-92
9399650-5	1997	Screening of cellular proteins enhanced in response to radicicol by two-dimensional gel electrophoresis suggested that the amount of gelsolin, an actin regulatory protein, was distinctly increased upon radicicol treatment.	monorden	55-64	gelsolin	Homo sapiens	133-141
8980876-1	1996	A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) secretion from THP-1 cells.	monorden	2-11	interleukin 1 beta	Homo sapiens	75-84
8980876-1	1996	A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) secretion from THP-1 cells.	monorden	2-11	tumor necrosis factor	Homo sapiens	120-129
8980876-2	1996	If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1 beta but also induced an extremely rapid degradation of IL-1 beta, IL-6 and TNF-alpha mRNA to undetectable levels within 5-8 h. This degradation is independent of translation and of the signal inducing transcription.	monorden	72-81	interleukin 1 beta	Homo sapiens	129-138
8980876-2	1996	If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1 beta but also induced an extremely rapid degradation of IL-1 beta, IL-6 and TNF-alpha mRNA to undetectable levels within 5-8 h. This degradation is independent of translation and of the signal inducing transcription.	monorden	72-81	interleukin 1 beta	Homo sapiens	190-199
8980876-2	1996	If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1 beta but also induced an extremely rapid degradation of IL-1 beta, IL-6 and TNF-alpha mRNA to undetectable levels within 5-8 h. This degradation is independent of translation and of the signal inducing transcription.	monorden	72-81	interleukin 6	Homo sapiens	201-205
8980876-2	1996	If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1 beta but also induced an extremely rapid degradation of IL-1 beta, IL-6 and TNF-alpha mRNA to undetectable levels within 5-8 h. This degradation is independent of translation and of the signal inducing transcription.	monorden	72-81	tumor necrosis factor	Homo sapiens	210-219
8824562-5	1996	Herbimycin A and radicicol, which have been reported to block Src function, suppressed the growth of v-src-transformed NRK and HAG-1 cells on the non-adhesive polyHEMA-surface at concentrations significantly lower than on plastic.	monorden	17-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	62-65
8824562-5	1996	Herbimycin A and radicicol, which have been reported to block Src function, suppressed the growth of v-src-transformed NRK and HAG-1 cells on the non-adhesive polyHEMA-surface at concentrations significantly lower than on plastic.	monorden	17-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	103-106
8824562-5	1996	Herbimycin A and radicicol, which have been reported to block Src function, suppressed the growth of v-src-transformed NRK and HAG-1 cells on the non-adhesive polyHEMA-surface at concentrations significantly lower than on plastic.	monorden	17-26	Nik related kinase	Homo sapiens	119-122
8824562-5	1996	Herbimycin A and radicicol, which have been reported to block Src function, suppressed the growth of v-src-transformed NRK and HAG-1 cells on the non-adhesive polyHEMA-surface at concentrations significantly lower than on plastic.	monorden	17-26	thioredoxin domain containing 12	Homo sapiens	127-132
7624124-0	1995	Suppression of RAS and MOS transformation by radicicol.	monorden	45-54	Moloney sarcoma oncogene	Mus musculus	23-26
7624124-2	1995	Radicicol (UCS1006), an antifungal antibiotic, had the ability to suppress transformation by ras and mos oncogenes in a rapid, reversible and dose-dependent manner.	monorden	0-9	Moloney sarcoma oncogene	Mus musculus	101-104
7624124-7	1995	These results suggest that agents such as radicicol can suppress transformation by diverse oncogenes such as src, ras and mos at least in part by inhibiting the function of key signal transduction intermediates such as MAP kinase and GAP-associated p62.	monorden	42-51	Rous sarcoma oncogene	Mus musculus	109-112
7624124-7	1995	These results suggest that agents such as radicicol can suppress transformation by diverse oncogenes such as src, ras and mos at least in part by inhibiting the function of key signal transduction intermediates such as MAP kinase and GAP-associated p62.	monorden	42-51	Moloney sarcoma oncogene	Mus musculus	122-125
7624124-7	1995	These results suggest that agents such as radicicol can suppress transformation by diverse oncogenes such as src, ras and mos at least in part by inhibiting the function of key signal transduction intermediates such as MAP kinase and GAP-associated p62.	monorden	42-51	nucleoporin 62	Mus musculus	249-252
7890656-6	1995	We report here that radicicol, a fungal antibiotic, is a potent protein tyrosine kinase inhibitor, and that it inhibits the expression of COX-2 without affecting COX-1 expression in lipopolysaccharide (LPS)-stimulated macrophages with the IC50 value of 27 nM.	monorden	20-29	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	138-143
8537316-5	1995	These results rule out the possibility that the morphological reversion by radicicol is due to direct or indirect inhibition of the p21ras function.	monorden	75-84	HRas proto-oncogene, GTPase	Homo sapiens	132-138
7890656-7	1995	Radicicol inhibited tyrosine phosphorylation of p53/56lyn, a Src family tyrosine kinase and one of the major tyrosine-phosphorylated proteins in LPS-stimulated macrophages.	monorden	0-9	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	48-51
7890656-8	1995	Radicicol also inhibited COX-2 expression in vivo in glomeruli of rats with experimental glomerulonephritis induced by the anti-glomerular basement membrane antibodies, in which COX-2 expression is known to be enhanced.	monorden	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	25-30
7890656-8	1995	Radicicol also inhibited COX-2 expression in vivo in glomeruli of rats with experimental glomerulonephritis induced by the anti-glomerular basement membrane antibodies, in which COX-2 expression is known to be enhanced.	monorden	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	178-183
7890656-14	1995	The magnitude of the inhibition of COX-2 protein synthesis by radicicol was much greater than that of the steady state levels of COX-2 mRNA.	monorden	62-71	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	35-40
7890656-15	1995	These results suggest that radicicol inhibits COX-2 expression mainly at post-transcriptional steps.	monorden	27-36	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	46-51
34262899-8	2021	The inhibition of Hsp90 ATPase activity by either geldanamycin or radicicol decreases the protein stability of filamin A.	monorden	66-75	heat shock protein 90 alpha family class A member 1	Homo sapiens	18-23
7521842-0	1994	Enhanced cell differentiation when RB is hypophosphorylated and down-regulated by radicicol, a SRC-kinase inhibitor.	monorden	82-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	95-98
7521842-1	1994	Radicicol, an inhibitor of src or src-like kinases, causes hypophosphorylation and down-regulation of the RB retinoblastoma tumor suppressor protein in HL-60 human promyelocytic leukemia cells.	monorden	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-30
7521842-1	1994	Radicicol, an inhibitor of src or src-like kinases, causes hypophosphorylation and down-regulation of the RB retinoblastoma tumor suppressor protein in HL-60 human promyelocytic leukemia cells.	monorden	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	34-37
1368339-0	1992	Radicicol, an agent inducing the reversal of transformed phenotypes of src-transformed fibroblasts.	monorden	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	71-74
34769027-6	2021	In fact, our results demonstrate that in the presence of radicicol, an inhibitor of Cx43 translocation to mitochondria, the cytoprotective effects of diazoxide disappear.	monorden	57-66	gap junction protein, alpha 1	Rattus norvegicus	84-88
34262899-8	2021	The inhibition of Hsp90 ATPase activity by either geldanamycin or radicicol decreases the protein stability of filamin A.	monorden	66-75	filamin A	Homo sapiens	111-120
35420390-4	2022	In cells lacking Mlp1, the Hsp90 inhibitor radicicol was found to inhibit the Slt2-mediated catalytic activation of Rlm1, but not the noncatalytic activation of Swi4/Swi6.	monorden	43-52	Mlp1p	Saccharomyces cerevisiae S288C	17-21
34221862-3	2021	The first discovered Hsp90 inhibitors, geldanamycin and radicicol, function by competitively binding to Hsp90"s N-terminal binding site and inhibiting its ATPase activity.	monorden	56-65	heat shock protein 90 alpha family class A member 1	Homo sapiens	21-26
34221862-3	2021	The first discovered Hsp90 inhibitors, geldanamycin and radicicol, function by competitively binding to Hsp90"s N-terminal binding site and inhibiting its ATPase activity.	monorden	56-65	heat shock protein 90 alpha family class A member 1	Homo sapiens	104-109
33802597-3	2021	Given the need to maximize treatment efficacy, the objective of this study was to use isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic techniques to identify proteins in human lung adenocarcinoma cell lines whose basal abundances were correlated with response to HSP90 inhibitors (geldanamycin and radicicol derivatives).	monorden	326-335	heat shock protein 90 alpha family class A member 1	Homo sapiens	291-296
33802597-5	2021	Likewise, rhotekin (RTKN) and decaprenyl diphosphate synthase subunit 2 (PDSS2) were correlated with sensitivity and resistance to radicicol derivatives.	monorden	131-140	rhotekin	Homo sapiens	10-18
33802597-5	2021	Likewise, rhotekin (RTKN) and decaprenyl diphosphate synthase subunit 2 (PDSS2) were correlated with sensitivity and resistance to radicicol derivatives.	monorden	131-140	rhotekin	Homo sapiens	20-24
33802597-5	2021	Likewise, rhotekin (RTKN) and decaprenyl diphosphate synthase subunit 2 (PDSS2) were correlated with sensitivity and resistance to radicicol derivatives.	monorden	131-140	decaprenyl diphosphate synthase subunit 2	Homo sapiens	30-71
33802597-5	2021	Likewise, rhotekin (RTKN) and decaprenyl diphosphate synthase subunit 2 (PDSS2) were correlated with sensitivity and resistance to radicicol derivatives.	monorden	131-140	decaprenyl diphosphate synthase subunit 2	Homo sapiens	73-78
35569376-5	2022	Either inhibitor of SLC6A14 (alpha-methyltryptophan) or of HSP90 (radicicol) had the cytotoxic effect, when added alone, while treatment with both compounds had a synergistic effect.	monorden	66-75	heat shock protein 90 alpha family class A member 1	Homo sapiens	59-64
35420390-4	2022	In cells lacking Mlp1, the Hsp90 inhibitor radicicol was found to inhibit the Slt2-mediated catalytic activation of Rlm1, but not the noncatalytic activation of Swi4/Swi6.	monorden	43-52	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	27-32
35420390-4	2022	In cells lacking Mlp1, the Hsp90 inhibitor radicicol was found to inhibit the Slt2-mediated catalytic activation of Rlm1, but not the noncatalytic activation of Swi4/Swi6.	monorden	43-52	Rlm1p	Saccharomyces cerevisiae S288C	116-120
32497199-5	2020	Consistently, other HSP90 inhibitors, including Radicicol, 17-DMAG and 17-AAG, all ameliorated pyroptosis in THP-1 cells by suppressing the inflammasome/Caspase-1/GSDMD signal pathway in pyroptosis.	monorden	48-57	heat shock protein 90 alpha family class A member 1	Homo sapiens	20-25
35311465-5	2022	Then, radicicol, an inhibitor of LKB1 pathway, was used to determine the role of NR4A1 in hepatocyte H/R injury by regulating LKB1.	monorden	6-15	serine/threonine kinase 11	Rattus norvegicus	33-37
35311465-5	2022	Then, radicicol, an inhibitor of LKB1 pathway, was used to determine the role of NR4A1 in hepatocyte H/R injury by regulating LKB1.	monorden	6-15	serine/threonine kinase 11	Rattus norvegicus	126-130
35311465-12	2022	Moreover, NR4A1 depletion conspicuously promoted cell viability, inhibited oxidative stress as well as inflammation, and induced apoptosis and autophagy in H/R-stimulated BRL-3A cells, which were reversed after radicicol intervention.	monorden	211-220	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	10-15
33903104-5	2021	As a result, we identified radicicol, a heat-shock protein 90 (Hsp90) inhibitor that effectively suppressed CHIKV replication by blocking the synthesis of both positive- and negative-strand viral RNA as well as expression of viral proteins.	monorden	27-36	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-68
33343615-5	2020	Experiments with zebrafish ZF4 cells showed that two differentially expressed genes atg9b and psmd12 were up-regulated by radicicol treatment and provided protective roles for cells under cold stress, indicating that up-regulation of autophagy and proteasome function contributes to enhanced cold tolerance.	monorden	122-131	autophagy related 9B	Danio rerio	84-89
33343615-5	2020	Experiments with zebrafish ZF4 cells showed that two differentially expressed genes atg9b and psmd12 were up-regulated by radicicol treatment and provided protective roles for cells under cold stress, indicating that up-regulation of autophagy and proteasome function contributes to enhanced cold tolerance.	monorden	122-131	proteasome 26S subunit, non-ATPase 12	Danio rerio	94-100
33077554-6	2020	Based on this evidence, we engineered a "chimeric" nano-therapeutic tool comprising taxanes and a cholesterol-tethered Hsp90 inhibitor, radicicol, which targets the tumor, reduces tolerance, and optimally re-primes NK cells via prolonged induction of NK-activating ligand receptors via temporal control of drug release in vitro and in vivo.	monorden	136-145	heat shock protein 90 alpha family class A member 1	Homo sapiens	119-124
32934719-2	2020	The original structures of geldanamycin and radicicol, which are known natural heat shock protein (HSP) inhibitors, were deeply modified because both of them exhibit several drawbacks, such as poor solubility, hepatotoxicity, intrinsic chemical instability or deprivation of the in vivo activity.	monorden	44-53	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	79-97
32934719-2	2020	The original structures of geldanamycin and radicicol, which are known natural heat shock protein (HSP) inhibitors, were deeply modified because both of them exhibit several drawbacks, such as poor solubility, hepatotoxicity, intrinsic chemical instability or deprivation of the in vivo activity.	monorden	44-53	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	99-102
32497199-5	2020	Consistently, other HSP90 inhibitors, including Radicicol, 17-DMAG and 17-AAG, all ameliorated pyroptosis in THP-1 cells by suppressing the inflammasome/Caspase-1/GSDMD signal pathway in pyroptosis.	monorden	48-57	caspase 1	Homo sapiens	153-162
32705166-5	2020	Rat H9c2 cardiomyoblasts were treated with Doxo in the absence or presence of radicicol, an inhibitor of Hsp90, the molecular chaperone involved in Cx43 translocation to the mitochondria that underlies its role in cardioprotection.	monorden	78-87	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	105-110
32705166-5	2020	Rat H9c2 cardiomyoblasts were treated with Doxo in the absence or presence of radicicol, an inhibitor of Hsp90, the molecular chaperone involved in Cx43 translocation to the mitochondria that underlies its role in cardioprotection.	monorden	78-87	gap junction protein, alpha 1	Rattus norvegicus	148-152
31326539-5	2019	Treatment with radicicol and VER155008, specific inhibitors of HSP90 and HSP70, respectively, attenuated these interactions and strongly reduced transporter presence at the cell surface, what resulted from the diminished level of the total transporter protein.	monorden	15-24	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-68
32599261-7	2020	Our data showed that inhibition of Cx43 translocation to mitochondria, obtained by radicicol pre-treatment, significantly increases cytosolic and mitochondrial superoxide formation, mitochondrial membrane depolarization and the consequent apoptosis induced by Trastuzumab.	monorden	83-92	gap junction protein, alpha 1	Rattus norvegicus	35-39
31632669-7	2019	In the liver, wild type (KF809856) and two splice variants of ANGPTL8 mRNA (KF809857 and KF809858) were found to be expressed.	monorden	76-84	angiopoietin like 8	Homo sapiens	62-69
31632669-7	2019	In the liver, wild type (KF809856) and two splice variants of ANGPTL8 mRNA (KF809857 and KF809858) were found to be expressed.	monorden	89-97	angiopoietin like 8	Homo sapiens	62-69
31632669-8	2019	The expression level of the splice variant KF809858, which produces a short form of ANGPTL8, accounted for <1% of ANGPTL8 in the liver.	monorden	43-51	angiopoietin like 8	Homo sapiens	84-91
31632669-8	2019	The expression level of the splice variant KF809858, which produces a short form of ANGPTL8, accounted for <1% of ANGPTL8 in the liver.	monorden	43-51	angiopoietin like 8	Homo sapiens	117-124
30488774-2	2019	The structure feature of 1a was different from our previously reported FTO inhibitors (radicicol, N-CDPCB and CHTB); the Cl and diol group in structure motif is critical for inhibitors to bind to FTO.	monorden	87-96	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	71-74
32295059-0	2020	Understanding the Hsp90 N-terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922).	monorden	136-145	heat shock protein 90 alpha family class A member 1	Homo sapiens	18-23
32295059-0	2020	Understanding the Hsp90 N-terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922).	monorden	155-164	heat shock protein 90 alpha family class A member 1	Homo sapiens	18-23
32295059-4	2020	Radicicol (RD) and its derivative, resorcinylic isoxazole amine NVP-AUY922 (NVP), have shown promising pharmacodynamics against Hsp90 activity.	monorden	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	128-133
31326539-5	2019	Treatment with radicicol and VER155008, specific inhibitors of HSP90 and HSP70, respectively, attenuated these interactions and strongly reduced transporter presence at the cell surface, what resulted from the diminished level of the total transporter protein.	monorden	15-24	heat shock protein family A (Hsp70) member 4	Homo sapiens	73-78
31298844-0	2019	An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol.	monorden	80-89	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	21-26
31298844-3	2019	This nitrogen-atom augmented radicicol derivative was found to be PTP1B selective relative to other highly homologous nonreceptor PTPs.	monorden	29-38	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	66-71
30612081-0	2019	Radicicol rescues yeast cell death triggered by expression of human alpha-synuclein and its A53T mutant, but not by human betaA4 peptide and proapoptotic protein bax.	monorden	0-9	synuclein alpha	Homo sapiens	68-83
30612081-3	2019	We have isolated radicicol, an Hsp90 inhibitor, from a fungus occurring in the crevices of marble rocks of Central India.	monorden	17-26	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	31-36
30612081-4	2019	Radicicol, which was found to be a strong antioxidant, was tested for its ability to rescue yeast cells from death induced by expression of wild-type alpha-synuclein, its more toxic A53T mutant, and betaA4.	monorden	0-9	synuclein alpha	Homo sapiens	150-165
30612081-8	2019	Our results indicate that radicicol specifically targets aggregated/misfolded alpha-synuclein"s toxicity and opens up the possibility of using multiple yeast assays to screen natural product libraries for compounds that would unambiguously target alpha-synuclein aggregation/misfolding.	monorden	26-35	synuclein alpha	Homo sapiens	78-93
30612081-8	2019	Our results indicate that radicicol specifically targets aggregated/misfolded alpha-synuclein"s toxicity and opens up the possibility of using multiple yeast assays to screen natural product libraries for compounds that would unambiguously target alpha-synuclein aggregation/misfolding.	monorden	26-35	synuclein alpha	Homo sapiens	247-262
30063141-0	2018	Identification of Natural Compound Radicicol as a Potent FTO Inhibitor.	monorden	35-44	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	57-60
30483129-11	2018	Moreover, the present study reveals that combination of radicicol, VER-155008, cyclosporine A, and FK506, which are specific pharmacological inhibitors of Hsp90, Hsp70, Cyps, and FKBPs, respectively, resulted in a stronger inhibition of intoxication of cells with C2 toxin compared to application of the single inhibitors.	monorden	56-65	heat shock protein 90 alpha family class A member 1	Homo sapiens	155-160
30483129-11	2018	Moreover, the present study reveals that combination of radicicol, VER-155008, cyclosporine A, and FK506, which are specific pharmacological inhibitors of Hsp90, Hsp70, Cyps, and FKBPs, respectively, resulted in a stronger inhibition of intoxication of cells with C2 toxin compared to application of the single inhibitors.	monorden	56-65	heat shock protein family A (Hsp70) member 4	Homo sapiens	162-167
30063141-2	2018	Virtual screening and similarity search in combination with bioactivity assay lead to the identification of the natural compound radicicol as a potent FTO inhibitor, which exhibits a dose-dependent inhibition of FTO demethylation activity with an IC50 value of 16.04 muM.	monorden	129-138	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	151-154
30063141-2	2018	Virtual screening and similarity search in combination with bioactivity assay lead to the identification of the natural compound radicicol as a potent FTO inhibitor, which exhibits a dose-dependent inhibition of FTO demethylation activity with an IC50 value of 16.04 muM.	monorden	129-138	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	212-215
30063141-3	2018	Further ITC experiments show that the binding between radicicol and FTO was mainly entropy-driven.	monorden	54-63	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	68-71
30063141-4	2018	Crystal structure analysis reveals that radicicol adopts an L-shaped conformation in the FTO binding site and occupies the same position as N-CDPCB, a previously identified small molecular inhibitor of FTO.	monorden	40-49	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	89-92
30063141-4	2018	Crystal structure analysis reveals that radicicol adopts an L-shaped conformation in the FTO binding site and occupies the same position as N-CDPCB, a previously identified small molecular inhibitor of FTO.	monorden	40-49	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	202-205
30063141-5	2018	Unexpectedly, however, the 1,3-diol group conserved in radicicol and N-CDPCB assumes strikingly different orientations for interaction with FTO.	monorden	55-64	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	140-143
30063141-6	2018	The identification of radicicol as an FTO inhibitor and revelation of its recognition mechanism not only opens the possibility of developing new therapeutic strategies for treatment of leukemia but also provide clues for elucidation of the acting mechanisms of radicicol, which is a possible clinical candidate worth in-depth study.	monorden	22-31	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	38-41
30063141-6	2018	The identification of radicicol as an FTO inhibitor and revelation of its recognition mechanism not only opens the possibility of developing new therapeutic strategies for treatment of leukemia but also provide clues for elucidation of the acting mechanisms of radicicol, which is a possible clinical candidate worth in-depth study.	monorden	261-270	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	38-41