PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2611263-1	1989	Xenopus transcription factor IIIA (TFIIIA) contains two tightly bound intrinsic Zn2+ ions that are released through treatment with either p-(hydroxymercuri)benzenesulfonate (PMPS) or diethyl pyrocarbonate (DEP) as monitored by the metallochromic indicator 4-(2-pyridylazo)resorcinol (PAR).	4-(2-pyridylazo)resorcinol	256-282	general transcription factor 3A L homeolog	Xenopus laevis	35-41
2611263-1	1989	Xenopus transcription factor IIIA (TFIIIA) contains two tightly bound intrinsic Zn2+ ions that are released through treatment with either p-(hydroxymercuri)benzenesulfonate (PMPS) or diethyl pyrocarbonate (DEP) as monitored by the metallochromic indicator 4-(2-pyridylazo)resorcinol (PAR).	4-(2-pyridylazo)resorcinol	284-287	general transcription factor 3A L homeolog	Xenopus laevis	35-41
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	4-(2-pyridylazo)resorcinol	42-45	poly (ADP-ribose) polymerase family, member 1	Mus musculus	147-152
3552036-0	1987	Effects of calcium ion on ternary complexes formed between 4-(2-pyridylazo)resorcinol and the two-zinc insulin hexamer.	4-(2-pyridylazo)resorcinol	59-85	insulin	Homo sapiens	103-110
18963641-1	1984	The ion-pair extraction equilibria of the iron(II) and iron(III) chelates of 4-(2-pyridylazo)resorcinol (PAR, H(2)L) are described.	4-(2-pyridylazo)resorcinol	77-103	jumping translocation breakpoint	Homo sapiens	105-108
6476384-4	1984	This problem has been avoided by extracting tissues with trichloroacetic acid, and measuring peroxide against catalase-treated blanks by its reaction with the complex of titanium(IV) with 4-(2-pyridylazo) resorcinol.	4-(2-pyridylazo)resorcinol	188-215	catalase	Homo sapiens	110-118
31911551-5	2020	We identified a novel posttranslational modification of 53BP1 by ADP-ribosylation that is targeted by a PAR-binding E3 ubiquitin ligase, RNF146, leading to 53BP1 polyubiquitination and degradation.	4-(2-pyridylazo)resorcinol	104-107	tumor protein p53 binding protein 1	Homo sapiens	56-61
31911551-5	2020	We identified a novel posttranslational modification of 53BP1 by ADP-ribosylation that is targeted by a PAR-binding E3 ubiquitin ligase, RNF146, leading to 53BP1 polyubiquitination and degradation.	4-(2-pyridylazo)resorcinol	104-107	ring finger protein 146	Homo sapiens	137-143
31911551-5	2020	We identified a novel posttranslational modification of 53BP1 by ADP-ribosylation that is targeted by a PAR-binding E3 ubiquitin ligase, RNF146, leading to 53BP1 polyubiquitination and degradation.	4-(2-pyridylazo)resorcinol	104-107	tumor protein p53 binding protein 1	Homo sapiens	156-161
30267646-9	2019	Under conditions of oxidative stress, ARH3-deficient cells showed increased cytosolic PAR accumulation and PARP-1 mediated cell death.	4-(2-pyridylazo)resorcinol	86-89	ADP-ribosylserine hydrolase	Mus musculus	38-42
31171201-4	2019	The second sensor, 4-(2-pyridylazo)-resorcinol-modified-TiO2NPs-based solid sensor (PAR@TiO2NPs), relies on the formation of a ternary complex between Ti(IV), PAR and H2O2.	4-(2-pyridylazo)resorcinol	19-46	jumping translocation breakpoint	Homo sapiens	84-87
31171201-4	2019	The second sensor, 4-(2-pyridylazo)-resorcinol-modified-TiO2NPs-based solid sensor (PAR@TiO2NPs), relies on the formation of a ternary complex between Ti(IV), PAR and H2O2.	4-(2-pyridylazo)resorcinol	19-46	jumping translocation breakpoint	Homo sapiens	159-162
30384244-1	2019	To advocate environment friendly detection idea, we adopted the green chemical method to synthesis the 1-(2 amino ethyl) piperidine functionalized polyacrylonitrile fiber (APF) and the chromogenic fiber 4-(2-pyridylazo) resorcinol (APF-PAR).	4-(2-pyridylazo)resorcinol	203-230	jumping translocation breakpoint	Homo sapiens	236-239
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	4-(2-pyridylazo)resorcinol	42-45	poly (ADP-ribose) polymerase family, member 1	Mus musculus	162-168
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	4-(2-pyridylazo)resorcinol	42-45	poly (ADP-ribose) polymerase family, member 2	Mus musculus	170-176
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	4-(2-pyridylazo)resorcinol	42-45	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	Mus musculus	178-189
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	4-(2-pyridylazo)resorcinol	42-45	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	Mus musculus	195-206
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	4-(2-pyridylazo)resorcinol	42-45	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	Mus musculus	208-216
28507315-3	2017	The N-terminus of UL31 contains sequences resembling a poly (ADP-ribose) (PAR) binding motif suggesting that PAR interactions might mediate UL31 recruitment to damaged DNA.	4-(2-pyridylazo)resorcinol	74-77	interacts with nuclear egress membrane protein	Human alphaherpesvirus 2	18-22
28507315-3	2017	The N-terminus of UL31 contains sequences resembling a poly (ADP-ribose) (PAR) binding motif suggesting that PAR interactions might mediate UL31 recruitment to damaged DNA.	4-(2-pyridylazo)resorcinol	74-77	interacts with nuclear egress membrane protein	Human alphaherpesvirus 2	140-144
27019333-1	2016	Mercury complex of 4-(2-pyridylazo)resorcinol (PAR-2Hg(2+)), a halide-ion chemosensor, was prepared and its efficiency as a tool for high-throughput screening (HTS) of transition-metal-catalyzed coupling reactions was investigated.	4-(2-pyridylazo)resorcinol	19-45	F2R like trypsin receptor 1	Homo sapiens	47-52
23487309-9	2013	Furthermore, we demonstrate that afadin is required for Par complex formation.	4-(2-pyridylazo)resorcinol	56-59	afadin, adherens junction formation factor	Mus musculus	33-39
24684389-4	2014	The nuclear translocation of this otherwise beneficial mitochondrial protein, occasioned by poly (ADP-ribose) (PAR) produced through PARP overactivation, causes large-scale DNA fragmentation and chromatin condensation, leading to cell death.	4-(2-pyridylazo)resorcinol	111-114	poly(ADP-ribose) polymerase 1	Homo sapiens	133-137
24827373-0	2014	A novel 4-(2-pyridylazo) resorcinol functionalised magnetic nanosorbent for selective extraction of Cu(II) and Pb(II) ions from food and water samples.	4-(2-pyridylazo)resorcinol	8-35	submaxillary gland androgen regulated protein 3B	Homo sapiens	100-117
24827373-1	2014	This paper describes a novel sorbent based on 4-(2-pyridylazo) resorcinol functionalised magnetic nanoparticles and its application for the extraction and pre-concentration of trace amounts of Cu(II) and Pb(II) ions.	4-(2-pyridylazo)resorcinol	46-73	submaxillary gland androgen regulated protein 3B	Homo sapiens	193-210
22127459-7	2012	MK-4827 reduced PAR levels in tumors by 1 h after administration which persisted for up to 24 h. This long period of PARP inhibition potentially adds to the flexibility of design of future clinical trials.	4-(2-pyridylazo)resorcinol	16-19	poly(ADP-ribose) polymerase 1	Homo sapiens	117-121
19435594-2	2009	The procedure exploits differences in the visible absorption spectra of the chromophoric chelator 4-(2-pyridylazo)resorcinol (PAR) resulting from its complexation to Zn2+ and/or Co2+ ions and is based on the fit of experimental spectra to a linear addition of Beer-Lambert law.	4-(2-pyridylazo)resorcinol	98-124	complement C2	Homo sapiens	178-181
21840394-2	2012	The addition of polymers of adenosine diphosphate (ADP)-ribose (PAR), which are synthesized by PAR polymerases (PARPs) from nicotinamide adenine dinucleotide (NAD), is one such distinctive post-translational modification.	4-(2-pyridylazo)resorcinol	64-67	poly(ADP-ribose) polymerase 1	Homo sapiens	112-117
19666485-5	2009	Alc1 is rapidly recruited to nucleosomes in vitro and to chromatin in cells when Parp1 catalyzes PAR synthesis.	4-(2-pyridylazo)resorcinol	97-100	chromodomain helicase DNA binding protein 1 like	Homo sapiens	0-4
19666485-5	2009	Alc1 is rapidly recruited to nucleosomes in vitro and to chromatin in cells when Parp1 catalyzes PAR synthesis.	4-(2-pyridylazo)resorcinol	97-100	poly(ADP-ribose) polymerase 1	Homo sapiens	81-86
20096995-1	2010	A new wearable colorimetric fiber for heavy metal ion detection and adsorption has been synthesized by first aminating a commercially available polyacrylonitrile fiber with ethylenediamine and then covalently immobilizing 4-(2-pyridylazo)-1,3-benzenediol (PAR) on the modified fiber through a Mannich reaction.	4-(2-pyridylazo)resorcinol	222-254	jumping translocation breakpoint	Homo sapiens	256-259
19435594-2	2009	The procedure exploits differences in the visible absorption spectra of the chromophoric chelator 4-(2-pyridylazo)resorcinol (PAR) resulting from its complexation to Zn2+ and/or Co2+ ions and is based on the fit of experimental spectra to a linear addition of Beer-Lambert law.	4-(2-pyridylazo)resorcinol	126-129	complement C2	Homo sapiens	178-181
18267089-8	2008	We propose that RhoA/Rho-kinase inhibits PAR complex formation through PAR-3 phosphorylation, resulting in Rac1 inactivation.	4-(2-pyridylazo)resorcinol	41-44	ras homolog family member A	Homo sapiens	16-20
18267089-8	2008	We propose that RhoA/Rho-kinase inhibits PAR complex formation through PAR-3 phosphorylation, resulting in Rac1 inactivation.	4-(2-pyridylazo)resorcinol	41-44	par-3 family cell polarity regulator	Homo sapiens	71-76
18267089-8	2008	We propose that RhoA/Rho-kinase inhibits PAR complex formation through PAR-3 phosphorylation, resulting in Rac1 inactivation.	4-(2-pyridylazo)resorcinol	41-44	Rac family small GTPase 1	Homo sapiens	107-111
18451636-1	2008	BACKGROUND/AIMS: The aim of this study was to investigate the serotonin transporter (SERT), by means of the 3H-paroxetine ([3H]-Par) binding to platelet membranes, in patients affected by pathological gambling (PG), as compared with a similar group of healthy control subjects.	4-(2-pyridylazo)resorcinol	128-131	solute carrier family 6 member 4	Homo sapiens	85-89
17828454-3	2007	We found that massive PAR synthesis leads to down-regulation of ERK1/2 phosphorylation, Bax translocation to the mitochondria, release of cytochrome c and AIF and subsequently cell death.	4-(2-pyridylazo)resorcinol	22-25	mitogen-activated protein kinase 3	Homo sapiens	64-70
17828454-3	2007	We found that massive PAR synthesis leads to down-regulation of ERK1/2 phosphorylation, Bax translocation to the mitochondria, release of cytochrome c and AIF and subsequently cell death.	4-(2-pyridylazo)resorcinol	22-25	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91
17828454-3	2007	We found that massive PAR synthesis leads to down-regulation of ERK1/2 phosphorylation, Bax translocation to the mitochondria, release of cytochrome c and AIF and subsequently cell death.	4-(2-pyridylazo)resorcinol	22-25	cytochrome c, somatic	Homo sapiens	138-150
17828454-3	2007	We found that massive PAR synthesis leads to down-regulation of ERK1/2 phosphorylation, Bax translocation to the mitochondria, release of cytochrome c and AIF and subsequently cell death.	4-(2-pyridylazo)resorcinol	22-25	apoptosis inducing factor mitochondria associated 1	Homo sapiens	155-158
18451636-1	2008	BACKGROUND/AIMS: The aim of this study was to investigate the serotonin transporter (SERT), by means of the 3H-paroxetine ([3H]-Par) binding to platelet membranes, in patients affected by pathological gambling (PG), as compared with a similar group of healthy control subjects.	4-(2-pyridylazo)resorcinol	128-131	solute carrier family 6 member 4	Homo sapiens	62-83
16808486-3	2006	In this paper, the decomposition of Cd2+ complex with 4-(2-pyridylazo)resorcinol has been tested, and its decomposition kinetics has been studied.	4-(2-pyridylazo)resorcinol	54-80	CD2 molecule	Homo sapiens	36-39
16959535-2	2007	The method is based on the complex formation of Co(II) and Pd(II) with 4-(2-pyridylazo) resorcinol (PAR) in acidic media and in the presence of sodium dodecyl sulfate (SDS) as a micellizing agent.	4-(2-pyridylazo)resorcinol	71-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
16959535-2	2007	The method is based on the complex formation of Co(II) and Pd(II) with 4-(2-pyridylazo) resorcinol (PAR) in acidic media and in the presence of sodium dodecyl sulfate (SDS) as a micellizing agent.	4-(2-pyridylazo)resorcinol	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
17239974-4	2007	Using the method of competition with the Zn2+ chelator 4-(2-pyridylazo)-resorcinol, an apparent Kd of 25 nM has been determined for Zn2+ binding to S100A2.	4-(2-pyridylazo)resorcinol	55-82	S100 calcium binding protein A2	Homo sapiens	148-154
16341850-1	2006	A novel and low-cost optical sensor for the naked eye detection of Cd2+ in aqueous media based on mesoporous silica containing 4-(2-pyridylazo)resorcinol (PAR) as a probe molecule anchored by N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride (TMAC) was prepared.	4-(2-pyridylazo)resorcinol	127-153	CD2 molecule	Homo sapiens	67-70
16341850-1	2006	A novel and low-cost optical sensor for the naked eye detection of Cd2+ in aqueous media based on mesoporous silica containing 4-(2-pyridylazo)resorcinol (PAR) as a probe molecule anchored by N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride (TMAC) was prepared.	4-(2-pyridylazo)resorcinol	155-158	CD2 molecule	Homo sapiens	67-70
14753768-7	2004	In the case of transition metals, the trace residues were leached with 10 mM HCl and after separation on a mixed bed analytical column (IonPac CS5) were detected by spectrophotometry after post column derivatisation using 4-(2-pyridylazo)resorcinol (PAR).	4-(2-pyridylazo)resorcinol	222-248	chorionic somatomammotropin hormone like 1	Homo sapiens	143-146
15286792-3	2004	Both phosphatidylinositol 3,4,5-trisphosphate and the evolutionarily conserved Par complex (comprising Par3, Par6 and an atypical PKC (aPKC) such as PKClambda or PKCzeta) are involved in axon specification.	4-(2-pyridylazo)resorcinol	79-82	par-3 family cell polarity regulator	Rattus norvegicus	103-107
14753768-7	2004	In the case of transition metals, the trace residues were leached with 10 mM HCl and after separation on a mixed bed analytical column (IonPac CS5) were detected by spectrophotometry after post column derivatisation using 4-(2-pyridylazo)resorcinol (PAR).	4-(2-pyridylazo)resorcinol	250-253	chorionic somatomammotropin hormone like 1	Homo sapiens	143-146
9585535-7	1998	Thus, MMP-3 removes a functional NH2-terminal u-PAR-binding domain from u-PA without affecting its enzymatic properties.	4-(2-pyridylazo)resorcinol	48-51	matrix metallopeptidase 3	Homo sapiens	6-11
12621128-5	2003	The intranuclear accumulation of PAR in cells preceded a positive terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick-end labeling, suggesting that PARP activation may actually contribute to delayed cell death.	4-(2-pyridylazo)resorcinol	33-36	DNA nucleotidylexotransferase	Rattus norvegicus	66-103
12621128-5	2003	The intranuclear accumulation of PAR in cells preceded a positive terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick-end labeling, suggesting that PARP activation may actually contribute to delayed cell death.	4-(2-pyridylazo)resorcinol	33-36	DNA nucleotidylexotransferase	Rattus norvegicus	105-108
12621128-5	2003	The intranuclear accumulation of PAR in cells preceded a positive terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick-end labeling, suggesting that PARP activation may actually contribute to delayed cell death.	4-(2-pyridylazo)resorcinol	33-36	poly (ADP-ribose) polymerase 1	Rattus norvegicus	166-170
9629569-6	1998	These findings suggest that [3H]-PAR in human resting lymphocytes specifically labels the 5-HT transporter.	4-(2-pyridylazo)resorcinol	33-36	solute carrier family 6 member 4	Homo sapiens	90-106
12195707-7	2002	These results demonstrate that regulation of COX-2 induction is an important functional response of HUVEC to PAR activation and suggest that PARs promote sustained upregulation of prostanoid production in human endothelium.	4-(2-pyridylazo)resorcinol	109-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
18968540-1	2002	The sequential simplex algorithm was used to optimize the ion-pair reversed phase high performance liquid chromatographic (IP-RPHPLC) analysis of 4-(2-pyridylazo)resorcinol (PAR) chelates of Co(II), Ni(II) and Cr(III).	4-(2-pyridylazo)resorcinol	146-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
18967724-1	1999	A colorimetric flow injection-system for the determination of Cu(II) in waters based on complexation reaction with 4-(2-pyridylazo)-resorcinol, usually termed PAR, is described.	4-(2-pyridylazo)resorcinol	115-142	jumping translocation breakpoint	Homo sapiens	159-162
34391789-2	2022	There is growing evidence suggesting that poly (ADP-ribose) polymerase 1 (PARP-1) hyperactivation is involved in various neurodegenerative disorders, including PD, and that poly (ADP-ribose) (PAR)-dependent cell death is responsible for neuronal loss.	4-(2-pyridylazo)resorcinol	192-195	poly(ADP-ribose) polymerase 1	Homo sapiens	42-72
9579661-6	1998	When p-hydroxymercuriphenyl sulfonate was used, nine sulfhydryl groups were detectable and the release of 1 mol of zinc per mole of CDA subunit was revealed by the metal indicator dye 4-(2-pyridylazo)resorcinol.	4-(2-pyridylazo)resorcinol	184-210	cytidine deaminase	Homo sapiens	132-135
8633785-9	1995	The ANN method was also used to resolve mixtures of Fe(III), Co(II), and Zn(II) by displacement from their EGTA complexes with 4-(2-pyridylazo)resorcinol (PAR) using a stopped-flow injection assembly including a diode array detector.	4-(2-pyridylazo)resorcinol	127-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
8633785-9	1995	The ANN method was also used to resolve mixtures of Fe(III), Co(II), and Zn(II) by displacement from their EGTA complexes with 4-(2-pyridylazo)resorcinol (PAR) using a stopped-flow injection assembly including a diode array detector.	4-(2-pyridylazo)resorcinol	155-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
34708032-2	2021	PARP1 functions by adding ADP-ribose polymers (PAR) to proteins including itself, using NAD+ as a donor.	4-(2-pyridylazo)resorcinol	47-50	poly(ADP-ribose) polymerase 1	Homo sapiens	0-5
34577191-1	2021	A monolithic rod of polyurethane foam-(4-(2-pyridylazo) resorcinol) (PUF-PAR) as a simple chemical sensor for lead assays with smartphone detection and image processing was developed.	4-(2-pyridylazo)resorcinol	38-67	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	69-72
2116409-2	1990	The release of Zn2+ from transcription factor IIIA (TFIIIA) was examined with the metallochromic indicator 4-(2-pyridylazo)resorcinol (PAR) in the absence and presence of p-hydroxymercuriphenylsulfonate (PMPS).	4-(2-pyridylazo)resorcinol	107-133	general transcription factor 3A L homeolog	Xenopus laevis	52-58
2116409-2	1990	The release of Zn2+ from transcription factor IIIA (TFIIIA) was examined with the metallochromic indicator 4-(2-pyridylazo)resorcinol (PAR) in the absence and presence of p-hydroxymercuriphenylsulfonate (PMPS).	4-(2-pyridylazo)resorcinol	135-138	general transcription factor 3A L homeolog	Xenopus laevis	52-58
2116409-3	1990	With 0.5 mM PAR, approximately 5 eq of Zn2+ were released from TFIIIA, but no Zn2+ release was detected from the 7 S ribonucleoprotein.	4-(2-pyridylazo)resorcinol	12-15	general transcription factor 3A L homeolog	Xenopus laevis	63-69
2116409-7	1990	The kinetic data of PAR and 5,5"-dithiobis-(2-nitrobenzoic acid) reactions with TFIIIA were similar, and the spectral changes were characterized by at least three exponential terms.	4-(2-pyridylazo)resorcinol	20-23	general transcription factor 3A L homeolog	Xenopus laevis	80-86
34391789-2	2022	There is growing evidence suggesting that poly (ADP-ribose) polymerase 1 (PARP-1) hyperactivation is involved in various neurodegenerative disorders, including PD, and that poly (ADP-ribose) (PAR)-dependent cell death is responsible for neuronal loss.	4-(2-pyridylazo)resorcinol	192-195	poly(ADP-ribose) polymerase 1	Homo sapiens	74-80