PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7811392-6	1994	A number of phenanthrene derivatives having a 9-hydroxy or 9-keto substituent, namely phenanthrenequinone, 6(5H)-phenanthridinone and 9-phenanthrol are potent inhibitors of bovine heart cAK (IC50 values 8, 10 and 10 microM, respectively) and of MLCK (IC50 values 6, 53 and 10 microM, respectively).	9-phenanthrol	134-147	myosin light chain kinase, smooth muscle	Bos taurus	245-249
34335274-15	2021	Application of 9-phenanthrol, both intracellularly and extracellularly, inhibited human TRPM4.	9-phenanthrol	15-28	transient receptor potential cation channel subfamily M member 4	Homo sapiens	88-93
34732535-7	2021	These oscillations were inhibited by two chemically-distinct blockers of TRPM4, 9-phenanthrol (9-pt) and 4-Chloro-2-((2-(2-chlorophenoxy)acetyl)amino)benzoic acid (CBA).	9-phenanthrol	80-93	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	73-78
34732535-7	2021	These oscillations were inhibited by two chemically-distinct blockers of TRPM4, 9-phenanthrol (9-pt) and 4-Chloro-2-((2-(2-chlorophenoxy)acetyl)amino)benzoic acid (CBA).	9-phenanthrol	95-99	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	73-78
34329682-4	2021	We found a significant Ca2+-activated cation current in PACs that was sensitive to the TRPM4 inhibitors 9-phenanthrol and CBA (4-Chloro-2-((2-(2-chlorophenoxy)acetyl)amino)benzoic acid).	9-phenanthrol	104-117	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	87-92
34335274-4	2021	Thus far, 9-phenanthrol is the most common pharmacological compound used to investigate TRPM4 function.	9-phenanthrol	10-23	transient receptor potential cation channel subfamily M member 4	Homo sapiens	88-93
34335274-17	2021	With intracellular 9-phenanthrol, we observed a tendency towards potentiation of mouse TRPM4 outward current at positive holding potentials.	9-phenanthrol	19-32	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	87-92
35099165-9	2022	FTMap underscores a conserved pocket in both TRPM4 and TRPM7, revealing a potential carvacrol binding site, and MCSA demonstrated that carvacrol shares a more than 85% similarity to 9-phenanthrol.	9-phenanthrol	182-195	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	45-50
35432302-6	2022	(Ca2+)i oscillations coincided with monovalent cation current that was suppressed by BAPTA, Ruthenium Red and the TRPM4 (Transient Receptor Potential Melastatin 4) channel inhibitor 9-phenanthrol.	9-phenanthrol	182-195	transient receptor potential cation channel subfamily M member 4	Homo sapiens	121-162
35432302-6	2022	(Ca2+)i oscillations coincided with monovalent cation current that was suppressed by BAPTA, Ruthenium Red and the TRPM4 (Transient Receptor Potential Melastatin 4) channel inhibitor 9-phenanthrol.	9-phenanthrol	182-195	transient receptor potential cation channel subfamily M member 4	Homo sapiens	114-119
35099165-9	2022	FTMap underscores a conserved pocket in both TRPM4 and TRPM7, revealing a potential carvacrol binding site, and MCSA demonstrated that carvacrol shares a more than 85% similarity to 9-phenanthrol.	9-phenanthrol	182-195	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	55-60
35163382-4	2022	TRPM4 function was tested with the TRPM4 antagonist 9-phenanthrol and the TRPM4 activator A23187 on the cardiovascular responses of the rat, in vivo and in isolated basilar, mesenteric, and skeletal muscle arteries.	9-phenanthrol	52-65	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	0-5
35163382-4	2022	TRPM4 function was tested with the TRPM4 antagonist 9-phenanthrol and the TRPM4 activator A23187 on the cardiovascular responses of the rat, in vivo and in isolated basilar, mesenteric, and skeletal muscle arteries.	9-phenanthrol	52-65	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	35-40
32001221-7	2020	The PACAP-induced current was inhibited by 30 muM 9-phenanthrol, a specific TRPM4 channel inhibitor, and abolished by replacement of external Na+ with N-methyl D-glucamine.	9-phenanthrol	52-63	adenylate cyclase activating polypeptide 1	Rattus norvegicus	4-9
35163382-5	2022	TRPM4 inhibition by 9-phenanthrol resulted in hypotension and a decreased heart rate in the rat.	9-phenanthrol	20-33	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	0-5
35163382-9	2022	Finally, TRPM4 activation by the Ca2+ ionophore A23187 was competitively inhibited by 9-phenanthrol.	9-phenanthrol	86-99	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	9-14
35163382-13	2022	Furthermore, the Ca2+ ionophore A23187 was identified as the first high-affinity (nanomolar) direct activator of TRPM4, acting on the 9-phenanthrol binding site.	9-phenanthrol	134-147	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	113-118
33392831-6	2021	This arrhythmic change disappeared after treatment with the TRPM4 channel blocker 9-phenanthrol or CaMKII inhibitor KN-62.	9-phenanthrol	82-95	transient receptor potential cation channel subfamily M member 4	Homo sapiens	60-65
32410961-7	2020	Such intrinsic activity was completely blocked at all electrodes by both the INaP blocker riluzole as well as by the ICAN blocker flufenamic acid (FFA) and the more specific TRPM4 channel antagonist 9-phenanthrol.	9-phenanthrol	199-212	transient receptor potential cation channel subfamily M member 4	Homo sapiens	174-179
33994959-9	2021	This current was dependent on intracellular Ca2+ (I CAN ) and sensitive to 9-phenanthrol (9-Ph).	9-phenanthrol	75-88	carbonic anhydrase 2	Mus musculus	44-47
33047172-5	2020	A typical TRPM4 current was recorded on human cells (equal selectivity for Na+ and K+, activation by internal Ca2+, voltage sensitivity, conductance of 23.2 pS, inhibition by 9-phenanthrol (IC50 = 6.1 x 10-6 mol L-1)).	9-phenanthrol	175-188	transient receptor potential cation channel subfamily M member 4	Homo sapiens	10-15
32685852-0	2020	Probing the Interaction between Human Serum Albumin and 9-Hydroxyphenanthrene: A Spectroscopic and Molecular Docking Study.	9-phenanthrol	56-77	albumin	Homo sapiens	44-51
32685852-2	2020	Herein, multispectroscopic and molecular docking techniques were applied to investigate the molecular interaction of human serum albumin (HSA) with 9-hydroxyphenanthrene (9-OHPhe) under simulated physiological conditions.	9-phenanthrol	148-169	albumin	Homo sapiens	123-136
32001221-7	2020	The PACAP-induced current was inhibited by 30 muM 9-phenanthrol, a specific TRPM4 channel inhibitor, and abolished by replacement of external Na+ with N-methyl D-glucamine.	9-phenanthrol	52-63	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 4	Cavia porcellus	76-81
32065126-9	2020	Specifically, we show that the TRPM4 channel blocker 9-phenanthrol reduces voltage-step evoked cation currents recorded with the amphotericin-B perforated patch-clamp approach.	9-phenanthrol	53-66	transient receptor potential cation channel subfamily M member 4	Homo sapiens	31-36
31851526-0	2020	TRPM4 channel inhibitors 9-phenanthrol and glibenclamide differentially decrease guinea pig detrusor smooth muscle whole-cell cation currents and phasic contractions.	9-phenanthrol	25-38	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 4	Cavia porcellus	0-5
30153324-0	2018	The transient receptor potential melastatin 4 channel inhibitor 9-phenanthrol modulates cardiac sodium channel.	9-phenanthrol	64-77	transient receptor potential cation channel subfamily M member 4	Homo sapiens	33-45
31054354-8	2019	RESULTS: ATO induced HUVEC cells injury, the significant upregulation of TRPM4 in this process was inhibited by 9-phenanthrol or siRNA.	9-phenanthrol	112-125	transient receptor potential cation channel subfamily M member 4	Homo sapiens	73-78
31073979-6	2019	A TRPM4 blocker, 9-phenanthrol (9-Phe), was infused through an intraventricular catheter connected to a programmed subcutaneous pump to evaluate the contribution of TRPM4 to SAH outcomes.	9-phenanthrol	17-30	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	2-7
31073979-13	2019	Cortical and global CBFs were reduced after SAH, but were restored significantly by 9-Phe, implying that TRPM4 contributed to CBF reduction after SAH.	9-phenanthrol	84-89	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	105-110
30789900-6	2019	Patch-clamp and field recordings from the preBotC in mouse slices also showed an increase in the frequency and a decrease in the magnitude of preBotC neural bursts in the presence of Trpm4 antagonist 9-phenanthrol, whereas the Trpc3 antagonist pyrazole-3 (pyr-3) showed inconsistent effects on magnitude and no effect on frequency.	9-phenanthrol	200-213	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	183-188
30518701-1	2019	Here, we investigated the effects of 9-hydroxyphenanthrene (9-phenanthrol), a potent and selective transient receptor potential melastatin 4 (TRPM4) channel blocker, on the resting membrane potential and cholinergic contractile responses to elucidate the functional role of TRPM4 channels in the contractile activities of mouse detrusor and ileal longitudinal smooth muscles.	9-phenanthrol	37-58	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	99-140
30153324-1	2018	BACKGROUND AND PURPOSE: 9-Phenanthrol, known as a specific inhibitor of the transient receptor potential melastatin 4 (TRMP4) channel, has been shown to modulate cardiac electrical activity and exert antiarrhythmic effects.	9-phenanthrol	24-37	transient receptor potential cation channel subfamily M member 4	Homo sapiens	105-117
30153324-10	2018	Further study revealed that 9-phenanthrol modulated the gating properties of cardiac sodium channels and dose-dependently inhibited INaL and peak sodium current (INaP ) in VMs with an IC50 of 18 and 71.5 muM respectively.	9-phenanthrol	28-41	NFKB inhibitor zeta	Homo sapiens	162-166
30153324-12	2018	CONCLUSIONS AND IMPLICATIONS: Our results indicate that 9-phenanthrol modulates the gating properties of cardiac sodium channels and inhibits INaL and INaP , which may contribute to its antiarrhythmic and cardioprotective effects.	9-phenanthrol	56-69	NFKB inhibitor zeta	Homo sapiens	151-155
28877214-12	2017	The actions of SUR1 and Trpm4 modulators were informative: like ghrelin, diazoxide, a SUR1 agonist, elevated [Ca2+]c and glibenclamide, a SUR1 antagonist, partially suppressed ghrelin action, while 9-phenanthrol and flufenamic acid, selective Trpm4 antagonists, blocked ghrelin actions on isolated neurons.	9-phenanthrol	198-211	ATP binding cassette subfamily C member 8	Homo sapiens	15-19
30054681-6	2018	Pharmacological block of TRPM4 with the antagonist, 9-Phenanthrol (30 muM) greatly reduced spontaneous phasic activity that developed after SCT, regardless of the presence or absence of the mucosa.	9-phenanthrol	52-65	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	25-30
29806985-0	2018	Transient receptor potential melastatin 4 channel inhibitor 9-phenanthrol inhibits K+ but not Ca2+ currents in canine ventricular myocytes.	9-phenanthrol	60-73	transient receptor potential cation channel subfamily M member 4	Canis lupus familiaris	0-41
29806985-1	2018	The role of transient receptor potential melastatin 4 (TRPM4) channels has been frequently tested using their inhibitor 9-phenanthrol in various cardiac preparations; however, the selectivity of the compound is uncertain.	9-phenanthrol	120-133	transient receptor potential cation channel subfamily M member 4	Canis lupus familiaris	12-53
29806985-1	2018	The role of transient receptor potential melastatin 4 (TRPM4) channels has been frequently tested using their inhibitor 9-phenanthrol in various cardiac preparations; however, the selectivity of the compound is uncertain.	9-phenanthrol	120-133	transient receptor potential cation channel subfamily M member 4	Canis lupus familiaris	55-60
29806985-9	2018	In conclusion, 9-phenanthrol is not selective to TRPM4 channels in canine ventricular myocardium; therefore, its application as a TRPM4 blocker can be appropriate only in expression systems but not in native cardiac cells.	9-phenanthrol	15-28	transient receptor potential cation channel subfamily M member 4	Canis lupus familiaris	130-135
29440991-10	2018	Our results show a specific localization of TRPM4 expression in neurons in the mPFC and that a 9-Phenanthrol sensitive current is active at resting membrane potential, suggesting specific functional roles in mPFC neurons during postnatal development and in adulthood.	9-phenanthrol	95-108	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	44-49
29440991-10	2018	Our results show a specific localization of TRPM4 expression in neurons in the mPFC and that a 9-Phenanthrol sensitive current is active at resting membrane potential, suggesting specific functional roles in mPFC neurons during postnatal development and in adulthood.	9-phenanthrol	95-108	complement factor properdin	Mus musculus	208-212
28877214-12	2017	The actions of SUR1 and Trpm4 modulators were informative: like ghrelin, diazoxide, a SUR1 agonist, elevated [Ca2+]c and glibenclamide, a SUR1 antagonist, partially suppressed ghrelin action, while 9-phenanthrol and flufenamic acid, selective Trpm4 antagonists, blocked ghrelin actions on isolated neurons.	9-phenanthrol	198-211	transient receptor potential cation channel subfamily M member 4	Homo sapiens	24-29
29098165-0	2017	A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans.	9-phenanthrol	18-31	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	2-7
28214884-8	2017	Cell viability decreased upon treatment with both agents in a concentration-dependent manner, which could be partially reversed by 9-phenanthrol, a specific TRPM4 inhibitor.	9-phenanthrol	131-144	transient receptor potential cation channel subfamily M member 4	Homo sapiens	157-162
28214884-9	2017	Exogenous H2O2 induced apoptosis, enhanced cell migration, and increased the release of adhesion molecules, including ICAM-1, VCAM-1, and E-selectin, all of which were significantly attenuated upon treatment with 9-phenanthrol.	9-phenanthrol	213-226	intercellular adhesion molecule 1	Homo sapiens	118-124
28475214-12	2017	In patch-clamp experiments using native cerebral arterial myocytes, membrane stretch-induced cation currents were blocked by the TRPM4 inhibitor 9-phenanthrol in both groups.	9-phenanthrol	145-158	transient receptor potential cation channel subfamily M member 4	Homo sapiens	129-134
28214884-9	2017	Exogenous H2O2 induced apoptosis, enhanced cell migration, and increased the release of adhesion molecules, including ICAM-1, VCAM-1, and E-selectin, all of which were significantly attenuated upon treatment with 9-phenanthrol.	9-phenanthrol	213-226	vascular cell adhesion molecule 1	Homo sapiens	126-132
28214884-9	2017	Exogenous H2O2 induced apoptosis, enhanced cell migration, and increased the release of adhesion molecules, including ICAM-1, VCAM-1, and E-selectin, all of which were significantly attenuated upon treatment with 9-phenanthrol.	9-phenanthrol	213-226	selectin E	Homo sapiens	138-148
29098165-3	2017	This channel is inhibited by 9-phenanthrol, which also inhibits the TMEM16a Cl- channel, and activates the Ca2+-activated K+ channel, Kca3.1.	9-phenanthrol	29-42	anoctamin 1	Rattus norvegicus	68-75
29098165-3	2017	This channel is inhibited by 9-phenanthrol, which also inhibits the TMEM16a Cl- channel, and activates the Ca2+-activated K+ channel, Kca3.1.	9-phenanthrol	29-42	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	134-140
29098165-9	2017	Inhibition of the GLP-1-induced insulin secretion by 20 muM and 30 muM 9-phenanthrol was 65% and 94%, respectively.	9-phenanthrol	71-84	glucagon	Rattus norvegicus	18-23
26548780-1	2016	KEY POINTS: The transient receptor potential melastatin 4 (TRPM4) inhibitor 9-phenanthrol reduces action potential duration in rabbit Purkinje fibres but not in ventricle.	9-phenanthrol	76-89	transient receptor potential cation channel subfamily M member 4	Homo sapiens	59-64
27246103-5	2016	Pharmacological inhibition of Sur1 (glibenclamide), Trpm4 (9-phenanthrol), or gene silencing of Abcc8 or Trpm4 reduced Nos2 upregulation.	9-phenanthrol	59-72	nitric oxide synthase 2	Rattus norvegicus	119-123
27956381-6	2016	The channel was inhibited by a specific TRPM4 inhibitor, 9-phenanthrol.	9-phenanthrol	57-70	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	40-45
26791488-9	2016	Patch-clamp experiments showed that 9-phenanthrol, a selective TRPM4 channel inhibitor, significantly decreased the transient inward cation currents and voltage step-induced whole cell currents in freshly isolated human DSM cells.	9-phenanthrol	36-49	transient receptor potential cation channel subfamily M member 4	Homo sapiens	63-68
26548780-8	2016	Intracellular microelectrodes recorded Purkinje fibre activity and the TRPM4 inhibitor 9-phenanthrol was applied to unmask potential TRPM4 contributions to the action potential.	9-phenanthrol	87-100	transient receptor potential cation channel subfamily M member 4	Homo sapiens	71-76
26548780-8	2016	Intracellular microelectrodes recorded Purkinje fibre activity and the TRPM4 inhibitor 9-phenanthrol was applied to unmask potential TRPM4 contributions to the action potential.	9-phenanthrol	87-100	transient receptor potential cation channel subfamily M member 4	Homo sapiens	133-138
26548780-11	2016	TRPM4-like single channel activity (conductance = 23.8 pS; equal permeability for Na(+) and K(+); sensitivity to voltage, Ca(2+) and 9-phenanthrol) was observed in 43% of patches from Purkinje cells but not from ventricular cells (0/16).	9-phenanthrol	133-146	transient receptor potential cation channel subfamily M member 4	Homo sapiens	0-5
25323322-0	2015	TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery.	9-phenanthrol	16-29	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	0-5
25573456-0	2015	9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels.	9-phenanthrol	0-13	anoctamin 1	Homo sapiens	56-63
25573456-3	2015	9-Phenanthrol, a putative selective TRPM4 channel inhibitor, abolishes myogenic tone in cerebral arteries, suggesting that either TRPM4 is essential for pressure-induced depolarization, upstream of activation of other ion channels or that 9-phenanthrol is non-selective.	9-phenanthrol	0-13	transient receptor potential cation channel subfamily M member 4	Homo sapiens	36-41
25573456-3	2015	9-Phenanthrol, a putative selective TRPM4 channel inhibitor, abolishes myogenic tone in cerebral arteries, suggesting that either TRPM4 is essential for pressure-induced depolarization, upstream of activation of other ion channels or that 9-phenanthrol is non-selective.	9-phenanthrol	0-13	transient receptor potential cation channel subfamily M member 4	Homo sapiens	130-135
25573456-4	2015	Here, we tested the hypothesis that 9-phenanthrol is also a TMEM16A channel blocker, an ion channel for which few inhibitors have been identified.	9-phenanthrol	36-49	anoctamin 1	Homo sapiens	60-67
25573456-6	2015	KEY RESULTS: 9-Phenanthrol blocked myocyte TMEM16A currents activated by either intracellular Ca(2+) or Eact , a TMEM16A channel activator.	9-phenanthrol	13-26	anoctamin 1	Homo sapiens	43-50
25573456-6	2015	KEY RESULTS: 9-Phenanthrol blocked myocyte TMEM16A currents activated by either intracellular Ca(2+) or Eact , a TMEM16A channel activator.	9-phenanthrol	13-26	anoctamin 1	Homo sapiens	113-120
25573456-8	2015	9-Phenanthrol reduced arterial myocyte TMEM16A currents with an IC50 of ~12 muM.	9-phenanthrol	0-13	anoctamin 1	Homo sapiens	39-46
25573456-9	2015	Cell-attached patch recordings indicated that 9-phenanthrol reduced single rTMEM16A channel open probability and mean open time, and increased mean closed time without affecting the amplitude.	9-phenanthrol	46-59	anoctamin 1	Rattus norvegicus	75-83
25573456-10	2015	CONCLUSIONS AND IMPLICATIONS: These data identify 9-phenanthrol as a novel TMEM16A channel blocker and provide an explanation for the previous observation that 9-phenanthrol abolishes myogenic tone when both TRPM4 and TMEM16A channels contribute to this response.	9-phenanthrol	50-63	anoctamin 1	Homo sapiens	75-82
25573456-10	2015	CONCLUSIONS AND IMPLICATIONS: These data identify 9-phenanthrol as a novel TMEM16A channel blocker and provide an explanation for the previous observation that 9-phenanthrol abolishes myogenic tone when both TRPM4 and TMEM16A channels contribute to this response.	9-phenanthrol	50-63	transient receptor potential cation channel subfamily M member 4	Homo sapiens	208-213
25573456-10	2015	CONCLUSIONS AND IMPLICATIONS: These data identify 9-phenanthrol as a novel TMEM16A channel blocker and provide an explanation for the previous observation that 9-phenanthrol abolishes myogenic tone when both TRPM4 and TMEM16A channels contribute to this response.	9-phenanthrol	50-63	anoctamin 1	Homo sapiens	218-225
25573456-10	2015	CONCLUSIONS AND IMPLICATIONS: These data identify 9-phenanthrol as a novel TMEM16A channel blocker and provide an explanation for the previous observation that 9-phenanthrol abolishes myogenic tone when both TRPM4 and TMEM16A channels contribute to this response.	9-phenanthrol	160-173	anoctamin 1	Homo sapiens	218-225
25573456-11	2015	9-Phenanthrol may be a promising candidate from which to develop TMEM16A channel-specific inhibitors.	9-phenanthrol	0-13	anoctamin 1	Homo sapiens	65-72
25836769-3	2015	Our previous study showed that 9-phenanthrol (9-Phe), a specific inhibitor of the TRPM4 channel, preserves cardiac contractile function and protects the heart from I/R injury-related infarction in the excised rat heart.	9-phenanthrol	31-44	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	82-87
25836769-3	2015	Our previous study showed that 9-phenanthrol (9-Phe), a specific inhibitor of the TRPM4 channel, preserves cardiac contractile function and protects the heart from I/R injury-related infarction in the excised rat heart.	9-phenanthrol	46-51	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	82-87
25836769-4	2015	Accordingly, we hypothesized that TRPM4 channels are involved in the 9-Phe-mediated cardioprotection against ROS-induced injury.	9-phenanthrol	69-74	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	34-39
25836769-10	2015	These results suggest that the cardioprotective effects of 9-Phe are mediated through the inhibition of the TRPM4 channels.	9-phenanthrol	59-64	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	108-113
25323322-2	2015	As TRPM4 channels are present throughout the vasculature, we investigated their potential role in non-myogenic resistance arteries using the TRPM4 inhibitor 9-phenanthrol.	9-phenanthrol	157-170	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	3-8
25323322-5	2015	KEY RESULTS: The TRPM4 inhibitor 9-phenanthrol reversibly hyperpolarized mesenteric arteries to circa EK and blocked alpha1 -adrenoceptor-mediated vasoconstriction.	9-phenanthrol	33-46	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	17-22
25323322-7	2015	In mesenteric and cerebral artery smooth muscle, 9-phenanthrol hyperpolarization was effectively blocked by the KCa 3.1 inhibitor TRAM-34.	9-phenanthrol	49-62	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	112-119
25323322-10	2015	CONCLUSIONS AND IMPLICATIONS: These data reveal a previously unrecognized action of the TRPM4 inhibitor 9-phenanthrol - the ability to act as an activator of EC KCa 3.1 channels.	9-phenanthrol	104-117	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	88-93
25323322-10	2015	CONCLUSIONS AND IMPLICATIONS: These data reveal a previously unrecognized action of the TRPM4 inhibitor 9-phenanthrol - the ability to act as an activator of EC KCa 3.1 channels.	9-phenanthrol	104-117	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	161-168
24043570-5	2014	Blocking TRPM4 with 9-phenanthrol greatly enhanced tube formation on Matrigel.	9-phenanthrol	20-33	transient receptor potential cation channel subfamily M member 4	Homo sapiens	9-14
25099756-6	2014	In addition, 9-phenanthrol substantially attenuated purinergic ligand-induced membrane depolarization and constriction of PAs, and inhibited ligand-evoked TRPM4 channel activation in isolated PA myocytes.	9-phenanthrol	13-26	transient receptor potential cation channel subfamily M member 4	Homo sapiens	155-160
25099756-4	2014	Here, we report that in vivo suppression of TRPM4 (transient receptor potential) channel expression, or inhibition of TRPM4 channels with 9-phenanthrol substantially reduced myogenic tone of isolated PAs, supporting a key role of TRPM4 channels in PA myogenic tone development.	9-phenanthrol	138-151	transient receptor potential cation channel subfamily M member 4	Homo sapiens	118-123
25099756-4	2014	Here, we report that in vivo suppression of TRPM4 (transient receptor potential) channel expression, or inhibition of TRPM4 channels with 9-phenanthrol substantially reduced myogenic tone of isolated PAs, supporting a key role of TRPM4 channels in PA myogenic tone development.	9-phenanthrol	138-151	transient receptor potential cation channel subfamily M member 4	Homo sapiens	118-123
25047048-7	2014	Next, endogenous TRPM4b-mediated currents were electrophysiologically characterized by application of glutamate and 9-phenanthrol, a TRPM4b specific antagonist in HT-22 cells which originated from mouse hippocampal neurons.	9-phenanthrol	116-129	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	17-23
24433510-0	2014	The TRPM4 channel inhibitor 9-phenanthrol.	9-phenanthrol	28-41	transient receptor potential cation channel subfamily M member 4	Homo sapiens	4-9
24433510-3	2014	In addition, 9-phenanthrol modulates a variety of physiological processes through TRPM4 current inhibition and thus exerts beneficial effects in several pathological conditions.	9-phenanthrol	13-26	transient receptor potential cation channel subfamily M member 4	Homo sapiens	82-87
23831210-5	2013	Here, we show by Fura2 Ca-imaging that pharmacological inhibition of TRPM4 in HL-1 mouse cardiac myocytes by 9-phenanthrol (10 muM) and flufenamic acid (10 and 100 muM) decreases Ca2+ oscillations followed by an overall increase in [Ca2+]i.	9-phenanthrol	109-122	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	69-74
24037125-0	2013	Control of urinary bladder smooth muscle excitability by the TRPM4 channel modulator 9-phenanthrol.	9-phenanthrol	85-98	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	61-66
24037125-4	2013	For the first time, we utilized the selective TRPM4 channel inhibitor, 9-phenanthrol, to investigate TRPM4 channel functional effects in DSM at both cellular and tissue levels in rodents.	9-phenanthrol	71-84	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	46-51
24037125-4	2013	For the first time, we utilized the selective TRPM4 channel inhibitor, 9-phenanthrol, to investigate TRPM4 channel functional effects in DSM at both cellular and tissue levels in rodents.	9-phenanthrol	71-84	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	101-106
23954346-7	2013	RESULTS: In the spontaneously beating mouse atrium, superfusion of the TRPM4-specific inhibitor 9-phenanthrol produced a concentration-dependent reduction in AP rate (maximal reduction = 62% that of control; EC50 = 8 x 10(-6) mol L(-1)) without affecting other AP parameters.	9-phenanthrol	96-109	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	71-76
23831210-8	2013	Furthermore, by on-cell voltage clamp we show that 9-phenanthrol reversibly inhibits membrane current; by fluorescence immunohistochemistry we demonstrate that HL-1 cells display punctate surface labeling with TRPM4 antibody; and by immunoblotting using this antibody we show these cells express a 130-150 kDa protein, as expected for TRPM4.	9-phenanthrol	51-64	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	210-215
23831210-8	2013	Furthermore, by on-cell voltage clamp we show that 9-phenanthrol reversibly inhibits membrane current; by fluorescence immunohistochemistry we demonstrate that HL-1 cells display punctate surface labeling with TRPM4 antibody; and by immunoblotting using this antibody we show these cells express a 130-150 kDa protein, as expected for TRPM4.	9-phenanthrol	51-64	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	335-340
23831210-9	2013	We conclude that 9-phenanthrol inhibits TRPM4 ion channels in HL-1 cells, which in turn decreases Ca2+ oscillations followed by a compensatory increase in [Ca2+]i from an intracellular store other than the sarcoplasmic reticulum.	9-phenanthrol	17-30	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	40-45
23936231-3	2013	Thus, the aim of this study was to examine the possible cardioprotective effect of 9-phenanthrol, a specific inhibitor of TRPM4.	9-phenanthrol	83-96	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	122-127
23416167-8	2013	Similarly, the TRPM4-inhibitor 9-phenanthrol reversibly reduced the duration of AP with an EC50 at 21x10(-6)mol L(-1), which is similar to that reported for TRPM4 current inhibition in HEK-293 cells.	9-phenanthrol	31-44	transient receptor potential cation channel subfamily M member 4	Homo sapiens	15-20
23416167-8	2013	Similarly, the TRPM4-inhibitor 9-phenanthrol reversibly reduced the duration of AP with an EC50 at 21x10(-6)mol L(-1), which is similar to that reported for TRPM4 current inhibition in HEK-293 cells.	9-phenanthrol	31-44	transient receptor potential cation channel subfamily M member 4	Homo sapiens	157-162
23416167-11	2013	Moreover, atria from Trpm4(-/-) mice exhibited an AP that was 20% shorter than that of atria from littermate control mice, and the effect of 9-phenanthrol on AP was abolished in the Trpm4(-/-) mice.	9-phenanthrol	141-154	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	21-26
23416167-11	2013	Moreover, atria from Trpm4(-/-) mice exhibited an AP that was 20% shorter than that of atria from littermate control mice, and the effect of 9-phenanthrol on AP was abolished in the Trpm4(-/-) mice.	9-phenanthrol	141-154	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	182-187
23283997-6	2013	9-Hydroxyphenanthrene (9-phenanthrol), a novel selective inhibitor of TRPM4 channels, was used to examine their role in DSM function.	9-phenanthrol	0-21	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	70-75
23283997-6	2013	9-Hydroxyphenanthrene (9-phenanthrol), a novel selective inhibitor of TRPM4 channels, was used to examine their role in DSM function.	9-phenanthrol	23-36	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	70-75
23283997-8	2013	Real-time DSM live-cell Ca(2+) imaging showed that selective inhibition of TRPM4 channels with 9-phenanthrol (30 muM) significantly reduced the intracellular Ca(2+) levels.	9-phenanthrol	95-108	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	75-80
21565835-8	2011	Pharmacological inhibition of TRPM4 with 9-phenanthrol or glibenclamide protects endothelium against LPS exposure for 48 h. Furthermore, TRPM4-like currents increase in cells pre-treated with LPS and inhibited with glibenclamide.	9-phenanthrol	41-54	transient receptor potential cation channel subfamily M member 4	Homo sapiens	30-35
22014185-0	2012	Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle.	9-phenanthrol	52-65	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	0-41
22014185-5	2012	The aim of this study was to investigate the possible anti-arrhythmic effect of 9-phenanthrol, a TRPM4 inhibitor in a murine heart model of hypoxia and re-oxygenation-induced EADs.	9-phenanthrol	80-93	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	97-102
22014185-14	2012	9-Phenanthrol abolished EADs, which strongly suggests the involvement of TRPM4 in the generation of EAD.	9-phenanthrol	0-13	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	73-78
21565835-8	2011	Pharmacological inhibition of TRPM4 with 9-phenanthrol or glibenclamide protects endothelium against LPS exposure for 48 h. Furthermore, TRPM4-like currents increase in cells pre-treated with LPS and inhibited with glibenclamide.	9-phenanthrol	41-54	transient receptor potential cation channel subfamily M member 4	Homo sapiens	137-142
20427713-7	2010	TICC activity was attenuated by the TRPM4 blockers fluflenamic acid and 9-phenanthrol.	9-phenanthrol	72-85	transient receptor potential cation channel subfamily M member 4	Homo sapiens	36-41
18297105-0	2008	9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.	9-phenanthrol	0-13	transient receptor potential cation channel subfamily M member 4	Homo sapiens	29-34
18297105-9	2008	In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50).	9-phenanthrol	13-26	CF transmembrane conductance regulator	Homo sapiens	70-74
18297105-9	2008	In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50).	9-phenanthrol	13-26	transient receptor potential cation channel subfamily M member 4	Homo sapiens	113-118
18297105-13	2008	CONCLUSIONS AND IMPLICATIONS: We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5.	9-phenanthrol	42-55	transient receptor potential cation channel subfamily M member 4	Homo sapiens	61-66
20826763-3	2010	A recent study shows that the tricyclic compound 9-phenanthrol inhibits TRPM4, but not the related channel TRPM5.	9-phenanthrol	49-62	transient receptor potential cation channel subfamily M member 4	Homo sapiens	72-77
20826763-5	2010	Patch-clamp electrophysiology revealed that 9-phenanthrol blocks native TRPM4 currents in freshly isolated smooth muscle cells in a concentration-dependent manner (IC(50) = 10.6 muM).	9-phenanthrol	44-57	transient receptor potential cation channel subfamily M member 4	Homo sapiens	72-77
20826763-5	2010	Patch-clamp electrophysiology revealed that 9-phenanthrol blocks native TRPM4 currents in freshly isolated smooth muscle cells in a concentration-dependent manner (IC(50) = 10.6 muM).	9-phenanthrol	44-57	latexin	Homo sapiens	178-181
20826763-8	2010	Using intracellular microelectrodes to record smooth muscle membrane potential in isolated cerebral arteries pressurized to 70 mmHg, we found that 9-phenanthrol (30 muM) reversibly hyperpolarized the membrane from ~-40 mV to ~-70 mV.	9-phenanthrol	147-160	latexin	Homo sapiens	165-168