PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27994550-5	2016	The aim of the present study was to evaluate anti-proliferative and apoptosis-inducing effect of TB on NSCLC (A549) cells, using MTT assay, morphological observation (DAPI staining), in situ terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, and annexin-V/PI flow cytometry.	theabrownin	97-99	annexin A5	Homo sapiens	271-280
33995088-4	2021	Surprisingly, TB significantly reduced the viabilities of HOG and U251 cells in a dose-dependent manner, which was accompanied by the upregulation of active-Casp-3, Bax, and PTEN; meanwhile, the antiapoptotic gene Bcl-2 was downregulated.	theabrownin	14-16	caspase 3	Homo sapiens	157-163
33995088-4	2021	Surprisingly, TB significantly reduced the viabilities of HOG and U251 cells in a dose-dependent manner, which was accompanied by the upregulation of active-Casp-3, Bax, and PTEN; meanwhile, the antiapoptotic gene Bcl-2 was downregulated.	theabrownin	14-16	BCL2 associated X, apoptosis regulator	Homo sapiens	165-168
33995088-4	2021	Surprisingly, TB significantly reduced the viabilities of HOG and U251 cells in a dose-dependent manner, which was accompanied by the upregulation of active-Casp-3, Bax, and PTEN; meanwhile, the antiapoptotic gene Bcl-2 was downregulated.	theabrownin	14-16	phosphatase and tensin homolog	Homo sapiens	174-178
33995088-4	2021	Surprisingly, TB significantly reduced the viabilities of HOG and U251 cells in a dose-dependent manner, which was accompanied by the upregulation of active-Casp-3, Bax, and PTEN; meanwhile, the antiapoptotic gene Bcl-2 was downregulated.	theabrownin	14-16	BCL2 apoptosis regulator	Homo sapiens	214-219
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	42-47
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	cyclin dependent kinase 2	Homo sapiens	59-63
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	cyclin dependent kinase 4	Homo sapiens	69-73
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	H3 histone pseudogene 16	Homo sapiens	94-97
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	dynactin subunit 6	Homo sapiens	102-105
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	tumor protein p53	Homo sapiens	142-145
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	H3 histone pseudogene 16	Homo sapiens	147-150
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	dynactin subunit 6	Homo sapiens	156-159
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	cyclin dependent kinase 2	Homo sapiens	59-62
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	0-2	cyclin A2	Homo sapiens	241-251
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	129-131	tumor protein p53	Homo sapiens	142-145
33995088-6	2021	TB treatment caused the downregulating of c-myc, cyclin D, CDK2, and CDK4 and upregulating of p21 and p27 in the HOG cell, while TB increased P53, p21, and p27 levels and decreased the levels of cell cycle regulator proteins such as CDK and cyclin A/B in the U251 cells.	theabrownin	129-131	H3 histone pseudogene 16	Homo sapiens	147-150
32982289-6	2020	SP600125 (JNK inhibitor) was in vivo and in vitro used to verify the regulatory role of the JNK signaling pathway in the anti-hepatic carcinoma mechanism of TB.	theabrownin	157-159	mitogen-activated protein kinase 8	Homo sapiens	92-95
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	71-75
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	BCL2 binding component 3	Homo sapiens	77-81
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	H3 histone pseudogene 16	Homo sapiens	83-86
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	BCL2 like 11	Homo sapiens	97-100
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	145-150
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	BCL2 associated X, apoptosis regulator	Homo sapiens	152-155
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	mitogen-activated protein kinase 8	Homo sapiens	172-175
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	196-201
32982289-8	2020	The molecular data showed that TB up-regulated the gene expressions of NOXA, PUMA, P21, Bax, and Bim and up-regulated the protein expressions of ASK-1, Bax, phosphorylated JNK, and phosphorylated c-Jun with down-regulation of Bcl-2.	theabrownin	31-33	BCL2 apoptosis regulator	Homo sapiens	226-231
32982289-10	2020	Furthermore, the JNK inhibitor significantly weakened TB"s effects both in vivo and in vitro and blocked the related molecular pathway.	theabrownin	54-56	mitogen-activated protein kinase 8	Homo sapiens	17-20
32982289-11	2020	Conclusion: TB exerts anti-proliferative, pro-apoptotic, and tumor-inhibitory effects on Huh7 cells through activation of the JNK signaling pathway.	theabrownin	12-14	mitogen-activated protein kinase 8	Homo sapiens	126-129
30119205-4	2018	Our in vitro studies showed that TB significantly suppressed RANKL-induced osteoclastogenesis and the expression of related marker proteins, including NFATc1, TRAP, c-Fos, and cathepsin K.	theabrownin	33-35	TNF superfamily member 11	Rattus norvegicus	61-66
30119205-4	2018	Our in vitro studies showed that TB significantly suppressed RANKL-induced osteoclastogenesis and the expression of related marker proteins, including NFATc1, TRAP, c-Fos, and cathepsin K.	theabrownin	33-35	nuclear factor of activated T-cells 1	Rattus norvegicus	151-157
30119205-4	2018	Our in vitro studies showed that TB significantly suppressed RANKL-induced osteoclastogenesis and the expression of related marker proteins, including NFATc1, TRAP, c-Fos, and cathepsin K.	theabrownin	33-35	tudor domain containing 7	Rattus norvegicus	159-163
30119205-4	2018	Our in vitro studies showed that TB significantly suppressed RANKL-induced osteoclastogenesis and the expression of related marker proteins, including NFATc1, TRAP, c-Fos, and cathepsin K.	theabrownin	33-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	165-170
30119205-4	2018	Our in vitro studies showed that TB significantly suppressed RANKL-induced osteoclastogenesis and the expression of related marker proteins, including NFATc1, TRAP, c-Fos, and cathepsin K.	theabrownin	33-35	cathepsin K	Rattus norvegicus	176-187
30119205-8	2018	Our study therefore demonstrated that TB can inhibit RANKL-induced osteoclastogenesis in vitro and prevent bone loss in ovariectomized rats.	theabrownin	38-40	TNF superfamily member 11	Rattus norvegicus	53-58
27994550-9	2016	The real time PCR assay demonstrated that TB down-regulated the expression of TOPO I, TOPO II, and BCL-2, and up-regulated the expression of E2F1, P53, GADD45, BAX, BIM, and CASP 3,7,8,9, which suggests an activation of P53-mediated apoptotic (caspase-dependent) pathway in response to TB treatment.	theabrownin	42-44	caspase 3	Homo sapiens	174-180
27994550-9	2016	The real time PCR assay demonstrated that TB down-regulated the expression of TOPO I, TOPO II, and BCL-2, and up-regulated the expression of E2F1, P53, GADD45, BAX, BIM, and CASP 3,7,8,9, which suggests an activation of P53-mediated apoptotic (caspase-dependent) pathway in response to TB treatment.	theabrownin	42-44	tumor protein p53	Homo sapiens	220-223
27994550-12	2016	Our results indicate that TB exhibits its anti-NSCLC activity via a P53-dependent mechanism, which may be a promising candidate of natural product for anti-cancer drug development in the treatment of NSCLC.	theabrownin	26-28	tumor protein p53	Homo sapiens	68-71
27994550-9	2016	The real time PCR assay demonstrated that TB down-regulated the expression of TOPO I, TOPO II, and BCL-2, and up-regulated the expression of E2F1, P53, GADD45, BAX, BIM, and CASP 3,7,8,9, which suggests an activation of P53-mediated apoptotic (caspase-dependent) pathway in response to TB treatment.	theabrownin	42-44	BCL2 apoptosis regulator	Homo sapiens	99-104
27994550-9	2016	The real time PCR assay demonstrated that TB down-regulated the expression of TOPO I, TOPO II, and BCL-2, and up-regulated the expression of E2F1, P53, GADD45, BAX, BIM, and CASP 3,7,8,9, which suggests an activation of P53-mediated apoptotic (caspase-dependent) pathway in response to TB treatment.	theabrownin	42-44	E2F transcription factor 1	Homo sapiens	141-145
27994550-9	2016	The real time PCR assay demonstrated that TB down-regulated the expression of TOPO I, TOPO II, and BCL-2, and up-regulated the expression of E2F1, P53, GADD45, BAX, BIM, and CASP 3,7,8,9, which suggests an activation of P53-mediated apoptotic (caspase-dependent) pathway in response to TB treatment.	theabrownin	42-44	tumor protein p53	Homo sapiens	147-150
27994550-9	2016	The real time PCR assay demonstrated that TB down-regulated the expression of TOPO I, TOPO II, and BCL-2, and up-regulated the expression of E2F1, P53, GADD45, BAX, BIM, and CASP 3,7,8,9, which suggests an activation of P53-mediated apoptotic (caspase-dependent) pathway in response to TB treatment.	theabrownin	42-44	growth arrest and DNA damage inducible alpha	Homo sapiens	152-158
27994550-9	2016	The real time PCR assay demonstrated that TB down-regulated the expression of TOPO I, TOPO II, and BCL-2, and up-regulated the expression of E2F1, P53, GADD45, BAX, BIM, and CASP 3,7,8,9, which suggests an activation of P53-mediated apoptotic (caspase-dependent) pathway in response to TB treatment.	theabrownin	42-44	BCL2 associated X, apoptosis regulator	Homo sapiens	160-163
20722930-7	2010	TB enhanced the activity of hepatic lipase and hormone-sensitive triglyceride lipase (HSL) and increased the HSL mRNA expression in liver tissue and epididymis tissue.	theabrownin	0-2	lipase C, hepatic type	Rattus norvegicus	28-42
20722930-7	2010	TB enhanced the activity of hepatic lipase and hormone-sensitive triglyceride lipase (HSL) and increased the HSL mRNA expression in liver tissue and epididymis tissue.	theabrownin	0-2	lipase E, hormone sensitive type	Rattus norvegicus	47-84
20722930-7	2010	TB enhanced the activity of hepatic lipase and hormone-sensitive triglyceride lipase (HSL) and increased the HSL mRNA expression in liver tissue and epididymis tissue.	theabrownin	0-2	lipase E, hormone sensitive type	Rattus norvegicus	86-89
20722930-7	2010	TB enhanced the activity of hepatic lipase and hormone-sensitive triglyceride lipase (HSL) and increased the HSL mRNA expression in liver tissue and epididymis tissue.	theabrownin	0-2	lipase E, hormone sensitive type	Rattus norvegicus	109-112
35271947-6	2022	The in vivo efficacy of TB on p53-deficient NSCLC (H1299) cells and p53-wild type NSCLC (A549) cells NSCLC cells were determined, and its mechanism of action was explored.	theabrownin	24-26	tumor protein p53	Homo sapiens	30-33
34581185-5	2021	Mechanistically, TB was shown to efficiently promote thermogenesis by stimulating the AMPK-PGC1alpha pathway with an increase in uncoupling protein 1 (UCP1).	theabrownin	17-19	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	91-100
34581185-5	2021	Mechanistically, TB was shown to efficiently promote thermogenesis by stimulating the AMPK-PGC1alpha pathway with an increase in uncoupling protein 1 (UCP1).	theabrownin	17-19	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	129-149
34581185-5	2021	Mechanistically, TB was shown to efficiently promote thermogenesis by stimulating the AMPK-PGC1alpha pathway with an increase in uncoupling protein 1 (UCP1).	theabrownin	17-19	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	151-155
34581185-6	2021	Conclusively, these findings suggest that long-term consumption of TB can enhance BAT activity and WAT browning by activating the AMPK-PGC1alpha pathway and modulating SCFAs; meanwhile, SCFAs regulating TB improved inflammatory disorder in HFD-fed mice.	theabrownin	67-69	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	135-144
35078476-10	2022	Moreover, by using JNK-siRNA, we found JNK as a bypass regulator in TB"s mechanism.	theabrownin	68-70	mitogen-activated protein kinase 8	Homo sapiens	19-22
35078476-10	2022	Moreover, by using JNK-siRNA, we found JNK as a bypass regulator in TB"s mechanism.	theabrownin	68-70	mitogen-activated protein kinase 8	Homo sapiens	39-42
35078476-11	2022	CONCLUSIONS: To sum up, TB exerted tumor-inhibitory, pro-senescent and pro-apoptotic effects on SK-Hep-1 cells through ATM-Chk2-p53 signaling axis in accompany with JNK bypass regulation.	theabrownin	24-26	ATM serine/threonine kinase	Homo sapiens	119-122
35078476-11	2022	CONCLUSIONS: To sum up, TB exerted tumor-inhibitory, pro-senescent and pro-apoptotic effects on SK-Hep-1 cells through ATM-Chk2-p53 signaling axis in accompany with JNK bypass regulation.	theabrownin	24-26	checkpoint kinase 2	Homo sapiens	123-127
35078476-11	2022	CONCLUSIONS: To sum up, TB exerted tumor-inhibitory, pro-senescent and pro-apoptotic effects on SK-Hep-1 cells through ATM-Chk2-p53 signaling axis in accompany with JNK bypass regulation.	theabrownin	24-26	tumor protein p53	Homo sapiens	128-131
35078476-11	2022	CONCLUSIONS: To sum up, TB exerted tumor-inhibitory, pro-senescent and pro-apoptotic effects on SK-Hep-1 cells through ATM-Chk2-p53 signaling axis in accompany with JNK bypass regulation.	theabrownin	24-26	mitogen-activated protein kinase 8	Homo sapiens	165-168
35078476-12	2022	This is the first report on the pro-senescent effect and multi-target (p53 and JNK) mechanism of TB on HCC cells, providing new insights into the underlying mechanisms of TB"s anti-HCC efficacy.	theabrownin	97-99	tumor protein p53	Homo sapiens	71-74
35078476-12	2022	This is the first report on the pro-senescent effect and multi-target (p53 and JNK) mechanism of TB on HCC cells, providing new insights into the underlying mechanisms of TB"s anti-HCC efficacy.	theabrownin	97-99	mitogen-activated protein kinase 8	Homo sapiens	79-82
35078476-12	2022	This is the first report on the pro-senescent effect and multi-target (p53 and JNK) mechanism of TB on HCC cells, providing new insights into the underlying mechanisms of TB"s anti-HCC efficacy.	theabrownin	171-173	tumor protein p53	Homo sapiens	71-74
35078476-12	2022	This is the first report on the pro-senescent effect and multi-target (p53 and JNK) mechanism of TB on HCC cells, providing new insights into the underlying mechanisms of TB"s anti-HCC efficacy.	theabrownin	171-173	mitogen-activated protein kinase 8	Homo sapiens	79-82