PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28229930-0	2017	Atrial natriuretic peptide: A novel mediator for TGF-beta1-induced epithelial-mesenchymal transition in 16HBE-14o and A549 cells.	16hbe	104-109	natriuretic peptide A	Homo sapiens	0-26
28400057-8	2017	The exposure of 16HBE to TSLP resulted in redistribution of E-cadherin.	16hbe	16-21	thymic stromal lymphopoietin	Mus musculus	25-29
28400057-8	2017	The exposure of 16HBE to TSLP resulted in redistribution of E-cadherin.	16hbe	16-21	cadherin 1	Mus musculus	60-70
28229930-0	2017	Atrial natriuretic peptide: A novel mediator for TGF-beta1-induced epithelial-mesenchymal transition in 16HBE-14o and A549 cells.	16hbe	104-109	transforming growth factor beta 1	Homo sapiens	49-58
24968834-5	2014	The 16HBE monolayer exposed to 0.1 ng/ml TSLP for 24 h showed the most obvious increase of TER and E-cadherin expression (P<0.05); FITC-DX fluorescence level was markedly decreased after TSLP exposure for 12 h and 24 h (P<0.05), and the effect was more obvious in 12 h group.	16hbe	4-9	thymic stromal lymphopoietin	Homo sapiens	41-45
27863410-6	2016	Significantly increased expression of STIM1 mRNA and protein was observed in 16HBE-benzo(a)pyrene (BaP) cells and in BaP-treated mice lung tissues compared with 16HBE-control cells and the control group, respectively.	16hbe	77-82	stromal interaction molecule 1	Mus musculus	38-43
27038884-10	2016	Furthermore, ISS from COPD patients reduced the nuclear levels of HDAC2 while increasing the activity of both Ac-His H3 (k9) and IKKalpha in stimulated 16HBE.	16hbe	152-157	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	129-137
24784499-9	2014	Pretreatment of 16HBE-14o cells with DHEA preserved the epithelial-like morphology, restored the expression of E-cadherin, and abolished the activation of a-SMA, and this effect is a PI3K-dependent mechanism.	16hbe	16-21	cadherin 1	Homo sapiens	111-121
24784499-9	2014	Pretreatment of 16HBE-14o cells with DHEA preserved the epithelial-like morphology, restored the expression of E-cadherin, and abolished the activation of a-SMA, and this effect is a PI3K-dependent mechanism.	16hbe	16-21	actin alpha 1, skeletal muscle	Homo sapiens	155-160
24968834-5	2014	The 16HBE monolayer exposed to 0.1 ng/ml TSLP for 24 h showed the most obvious increase of TER and E-cadherin expression (P<0.05); FITC-DX fluorescence level was markedly decreased after TSLP exposure for 12 h and 24 h (P<0.05), and the effect was more obvious in 12 h group.	16hbe	4-9	cadherin 1	Homo sapiens	99-109
24968834-5	2014	The 16HBE monolayer exposed to 0.1 ng/ml TSLP for 24 h showed the most obvious increase of TER and E-cadherin expression (P<0.05); FITC-DX fluorescence level was markedly decreased after TSLP exposure for 12 h and 24 h (P<0.05), and the effect was more obvious in 12 h group.	16hbe	4-9	thymic stromal lymphopoietin	Homo sapiens	190-194
21756783-7	2011	For 16HBE group, expression of PARP 1 and DNMT 1 were 141.0%, 158.0%, 167.0%, 239.0%, 149.0%, 82.9% and 108.0%, 117.0%, 125.0%, 162.0%, 275.0%, 233.0% comparing with the control group, whose difference also has statistical significance (t values were 11.45, 17.32, 32.24, 33.44, 20.21 and 9.87, P < 0.01).	16hbe	4-9	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
23969332-8	2013	16HBE treated with BDP or formoterol alone partially suppressed the effect of IL-17A or CSE on ROS, NT, and STAT-1 activation.	16hbe	0-5	interleukin 17A	Homo sapiens	78-84
23969332-8	2013	16HBE treated with BDP or formoterol alone partially suppressed the effect of IL-17A or CSE on ROS, NT, and STAT-1 activation.	16hbe	0-5	signal transducer and activator of transcription 1	Homo sapiens	108-114
21726609-0	2011	The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide.	16hbe	35-40	microRNA 506	Homo sapiens	12-19
21756783-7	2011	For 16HBE group, expression of PARP 1 and DNMT 1 were 141.0%, 158.0%, 167.0%, 239.0%, 149.0%, 82.9% and 108.0%, 117.0%, 125.0%, 162.0%, 275.0%, 233.0% comparing with the control group, whose difference also has statistical significance (t values were 11.45, 17.32, 32.24, 33.44, 20.21 and 9.87, P < 0.01).	16hbe	4-9	DNA methyltransferase 1	Homo sapiens	42-48
21756783-8	2011	For 16HBE-shPARP1 group, expression of PARP 1 and DNMT 1 were 169.0%, 217.0%, 259.0%, 323.0%, 321.0%, 256.0% and 86.0%, 135.0%, 151.0%, 180.0%, 229.0%, 186.0% comparing with the control group, with statistical significance (t values were 9.06, 15.92, 22.68, 26.23, 37.19 and 21.15, P < 0.01).	16hbe	4-9	poly(ADP-ribose) polymerase 1	Homo sapiens	39-45
21756783-8	2011	For 16HBE-shPARP1 group, expression of PARP 1 and DNMT 1 were 169.0%, 217.0%, 259.0%, 323.0%, 321.0%, 256.0% and 86.0%, 135.0%, 151.0%, 180.0%, 229.0%, 186.0% comparing with the control group, with statistical significance (t values were 9.06, 15.92, 22.68, 26.23, 37.19 and 21.15, P < 0.01).	16hbe	4-9	DNA methyltransferase 1	Homo sapiens	50-56
20123007-6	2010	The mRNA expression and methylation status of PARP-1 in M-16HBE with or without treatment of the cytosine methylation inhibitor 5-aza-2"-deoxycytidine (5-aza) were detected by real-time PCR and methylation-specific PCR (MSP), respectively.	16hbe	58-63	poly(ADP-ribose) polymerase 1	Homo sapiens	46-52
19247804-5	2009	Compare with 16HBE, the PARP1-deficient cells were more sensitive to the damage caused by BaP.	16hbe	13-18	poly(ADP-ribose) polymerase 1	Homo sapiens	24-29
19247804-8	2009	According to results, we came to the conclusion that PARP1-deficient cells were more sensitive to BaP in contrast to normal 16HBE; DNA repair capacity in PARP1-deficient cells decreased significantly at the early stage of repair, but increased to the equivalent level of normal 16HBE in the later period.	16hbe	278-283	poly(ADP-ribose) polymerase 1	Homo sapiens	53-58
19247804-8	2009	According to results, we came to the conclusion that PARP1-deficient cells were more sensitive to BaP in contrast to normal 16HBE; DNA repair capacity in PARP1-deficient cells decreased significantly at the early stage of repair, but increased to the equivalent level of normal 16HBE in the later period.	16hbe	278-283	poly(ADP-ribose) polymerase 1	Homo sapiens	154-159
32771949-11	2020	In addition, PNS-R1 suppressed TNF-alpha/NF-kappaB pathway in both asthmatic mice and 16HBE.	16hbe	86-91	tumor necrosis factor	Mus musculus	31-40
18303620-2	2007	METHODS: The levels of HER2/neu mRNA and protein expressions, and its protein localization were examined in the malignant transformed 16HBE (16HBE-T) induced by 2.0 micromol/L anti-BPDE and untransformed control 16HBE (16HBE-N) using semi-quantitative RT-PCR, SYBR Green I Real time quantitative RT-PCR (QRT-PCR), western blot and immunocytochemical method respectively.	16hbe	134-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
18303620-2	2007	METHODS: The levels of HER2/neu mRNA and protein expressions, and its protein localization were examined in the malignant transformed 16HBE (16HBE-T) induced by 2.0 micromol/L anti-BPDE and untransformed control 16HBE (16HBE-N) using semi-quantitative RT-PCR, SYBR Green I Real time quantitative RT-PCR (QRT-PCR), western blot and immunocytochemical method respectively.	16hbe	141-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
18303620-2	2007	METHODS: The levels of HER2/neu mRNA and protein expressions, and its protein localization were examined in the malignant transformed 16HBE (16HBE-T) induced by 2.0 micromol/L anti-BPDE and untransformed control 16HBE (16HBE-N) using semi-quantitative RT-PCR, SYBR Green I Real time quantitative RT-PCR (QRT-PCR), western blot and immunocytochemical method respectively.	16hbe	141-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-31
18303620-2	2007	METHODS: The levels of HER2/neu mRNA and protein expressions, and its protein localization were examined in the malignant transformed 16HBE (16HBE-T) induced by 2.0 micromol/L anti-BPDE and untransformed control 16HBE (16HBE-N) using semi-quantitative RT-PCR, SYBR Green I Real time quantitative RT-PCR (QRT-PCR), western blot and immunocytochemical method respectively.	16hbe	141-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
18303620-2	2007	METHODS: The levels of HER2/neu mRNA and protein expressions, and its protein localization were examined in the malignant transformed 16HBE (16HBE-T) induced by 2.0 micromol/L anti-BPDE and untransformed control 16HBE (16HBE-N) using semi-quantitative RT-PCR, SYBR Green I Real time quantitative RT-PCR (QRT-PCR), western blot and immunocytochemical method respectively.	16hbe	141-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-31
18303620-2	2007	METHODS: The levels of HER2/neu mRNA and protein expressions, and its protein localization were examined in the malignant transformed 16HBE (16HBE-T) induced by 2.0 micromol/L anti-BPDE and untransformed control 16HBE (16HBE-N) using semi-quantitative RT-PCR, SYBR Green I Real time quantitative RT-PCR (QRT-PCR), western blot and immunocytochemical method respectively.	16hbe	141-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
18303620-2	2007	METHODS: The levels of HER2/neu mRNA and protein expressions, and its protein localization were examined in the malignant transformed 16HBE (16HBE-T) induced by 2.0 micromol/L anti-BPDE and untransformed control 16HBE (16HBE-N) using semi-quantitative RT-PCR, SYBR Green I Real time quantitative RT-PCR (QRT-PCR), western blot and immunocytochemical method respectively.	16hbe	141-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-31
18303620-6	2007	The activity of HER2/neu oncogene might play an important role in the malignant transformed 16HBE induced by anti-BPDE.	16hbe	92-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	16-24
34476934-9	2021	PRMT5 was enhanced in cigarette smoke extract-induced 16HBE.	16hbe	54-59	protein arginine methyltransferase 5	Homo sapiens	0-5
34476934-10	2021	Knockdown of PRMT5 increased cell viability of cigarette smoke extract-induced 16HBE, and attenuated cigarette smoke extract-induced increase of IL-6, IL-8, TNF-alpha, and IL-1beta.	16hbe	79-84	protein arginine methyltransferase 5	Homo sapiens	13-18
34476934-11	2021	Up-regulation of C-X-C Motif Chemokine 10 (CXCL10) in cigarette smoke extract-induced 16HBE was restored by knockdown of PRMT5.	16hbe	86-91	C-X-C motif chemokine ligand 10	Homo sapiens	17-41
34476934-11	2021	Up-regulation of C-X-C Motif Chemokine 10 (CXCL10) in cigarette smoke extract-induced 16HBE was restored by knockdown of PRMT5.	16hbe	86-91	C-X-C motif chemokine ligand 10	Homo sapiens	43-49
34476934-11	2021	Up-regulation of C-X-C Motif Chemokine 10 (CXCL10) in cigarette smoke extract-induced 16HBE was restored by knockdown of PRMT5.	16hbe	86-91	protein arginine methyltransferase 5	Homo sapiens	121-126
34476934-13	2021	Moreover, PRMT5 silence-induced increase of cell viability in cigarette smoke extract-induced 16HBE was reversed by over-expression of CXCL10.	16hbe	94-99	protein arginine methyltransferase 5	Homo sapiens	10-15
34476934-13	2021	Moreover, PRMT5 silence-induced increase of cell viability in cigarette smoke extract-induced 16HBE was reversed by over-expression of CXCL10.	16hbe	94-99	C-X-C motif chemokine ligand 10	Homo sapiens	135-141
34476934-14	2021	CONCLUSION: Knockdown of PRMT5 promoted cell viability of cigarette smoke extract-induced 16HBE, and reduced inflammation through down-regulation of CXCL10.	16hbe	90-95	protein arginine methyltransferase 5	Homo sapiens	25-30
34125980-0	2021	Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis.	16hbe	170-175	lung cancer associated transcript 1	Homo sapiens	34-40
33301441-0	2020	Retinoic acid improves baseline barrier function and attenuates TNF-alpha-induced barrier leak in human bronchial epithelial cell culture model, 16HBE 14o.	16hbe	145-150	tumor necrosis factor	Homo sapiens	64-73
33301441-5	2020	RA was also effective in alleviating TNF-alpha-induced 16HBE barrier leak, attenuating 60% of the TNF-alpha-induced leak to 14C-mannitol and 80% of the leak to 14C-inulin.	16hbe	55-60	tumor necrosis factor	Homo sapiens	37-46
32571119-7	2020	Furthermore, miR-92a blocked interleukin (IL)-13-induced MUC5AC luciferase activity in 16HBE.	16hbe	87-92	interleukin 13	Mus musculus	29-48
32571119-7	2020	Furthermore, miR-92a blocked interleukin (IL)-13-induced MUC5AC luciferase activity in 16HBE.	16hbe	87-92	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	57-63
32985670-9	2020	Investigating the dependence of 16HBE TER on transcellular ion conductance, inhibition of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel with GlyH-101 produced a large decrease in short circuit current (Isc) and a slight increase in TER, but no significant change in Jm.	16hbe	32-37	CF transmembrane conductance regulator	Homo sapiens	94-145
32985670-9	2020	Investigating the dependence of 16HBE TER on transcellular ion conductance, inhibition of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel with GlyH-101 produced a large decrease in short circuit current (Isc) and a slight increase in TER, but no significant change in Jm.	16hbe	32-37	CF transmembrane conductance regulator	Homo sapiens	147-151
33035699-12	2020	Overexpressed ORMDL3 enhanced migration and viability, decreased E-cadherin level, increased the levels of IL-33and Vimentin, and promoted the phosphorylation of NF-kappaB and MAPK/ERK in Dex-treated 16HBE-14o cells, thus reversing the effect of Dex treatment.	16hbe	200-205	ORMDL sphingolipid biosynthesis regulator 3	Homo sapiens	14-20
33035699-13	2020	However, siRNA-IL-33 inhibited viability and migration, increased E-cadherin level, decreased Vimentin level, and suppressed the phosphorylation of NF-kappaB and MAPK/ERK, thus reversing the effect of overexpressed ORMDL3 in Dex-treated 16HBE-14o cells.	16hbe	237-242	nuclear factor kappa B subunit 1	Homo sapiens	148-157
18953964-2	2008	This study was to explore the role of ginkgolide B in inhibiting the synthesis of IL-8 induced by 4-HNE in 16HBE.	16hbe	107-112	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18242599-4	2008	Additionally, we tested the IL-8-mediated neutrophil chemotactic activity of 16HBE supernatants stimulated with acetylcholine in the presence or absence of tiotropium.	16hbe	77-82	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
33928340-8	2021	Notably, the oncogenic transformation of 16HBE leads to decreased linc01125 in cells but increased linc01125 in cell-derived exosomes.	16hbe	41-46	chromosome 2 open reading frame 92	Homo sapiens	66-75
33928340-8	2021	Notably, the oncogenic transformation of 16HBE leads to decreased linc01125 in cells but increased linc01125 in cell-derived exosomes.	16hbe	41-46	chromosome 2 open reading frame 92	Homo sapiens	99-108
33080424-11	2021	In conclusion, this study revealed a new mechanism by which the miR-140-5p/TLR4 signaling pathway mediated the inflammatory response of 16HBE cells induced by PM2.5.	16hbe	136-141	microRNA 140	Homo sapiens	64-71
33080424-11	2021	In conclusion, this study revealed a new mechanism by which the miR-140-5p/TLR4 signaling pathway mediated the inflammatory response of 16HBE cells induced by PM2.5.	16hbe	136-141	toll like receptor 4	Homo sapiens	75-79
32771949-11	2020	In addition, PNS-R1 suppressed TNF-alpha/NF-kappaB pathway in both asthmatic mice and 16HBE.	16hbe	86-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	41-50
32833955-8	2020	16HBE cells were utilized to explore the effect of QXT or hydrogen peroxide (H2O2) on the expression of E-cadherin in vitro.	16hbe	0-5	cadherin 1	Homo sapiens	104-114
30289508-7	2019	Interference with linc00152 expression led to G1/S arrest and inhibition of proliferation of 16HBE-M and H1299 cells.	16hbe	93-98	cytoskeleton regulator RNA	Homo sapiens	18-27
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	16hbe	129-134	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	16hbe	129-134	interleukin 1 alpha	Homo sapiens	58-66
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	16hbe	129-134	nuclear factor kappa B subunit 1	Homo sapiens	81-90
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	16hbe	199-204	nuclear factor kappa B subunit 1	Homo sapiens	52-61
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	16hbe	199-204	microRNA 498	Homo sapiens	101-108
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	16hbe	199-204	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	16hbe	199-204	interleukin 1 alpha	Homo sapiens	163-171
29543496-7	2018	In addition, pretreatment of 16HBE cells with miR-21 inhibitor significantly inhibited autophagy activity and decreased apoptosis, indicating that miR-21 is involved in CSE-induced autophagy and apoptosis.	16hbe	29-34	microRNA 21	Homo sapiens	46-52
29656209-7	2018	RESULTS: The results showed that RAGE inhibition or RAGE knockdown decreased beta-catenin nuclear accumulation and the expression of relevant beta-catenin targeted genes (VEGF, MMP9, TGF-beta1) in the TDI-induced murine asthma model and TDI-HSA-treated 16HBE cells, respectively.	16hbe	253-258	advanced glycosylation end product-specific receptor	Mus musculus	33-37
29656209-7	2018	RESULTS: The results showed that RAGE inhibition or RAGE knockdown decreased beta-catenin nuclear accumulation and the expression of relevant beta-catenin targeted genes (VEGF, MMP9, TGF-beta1) in the TDI-induced murine asthma model and TDI-HSA-treated 16HBE cells, respectively.	16hbe	253-258	advanced glycosylation end product-specific receptor	Mus musculus	52-56
29543496-7	2018	In addition, pretreatment of 16HBE cells with miR-21 inhibitor significantly inhibited autophagy activity and decreased apoptosis, indicating that miR-21 is involved in CSE-induced autophagy and apoptosis.	16hbe	29-34	microRNA 21	Homo sapiens	147-153
29543496-7	2018	In addition, pretreatment of 16HBE cells with miR-21 inhibitor significantly inhibited autophagy activity and decreased apoptosis, indicating that miR-21 is involved in CSE-induced autophagy and apoptosis.	16hbe	29-34	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	169-172
28784314-4	2017	Levels of CLU and NRP2 were significant elevated in both culture supernatant of T-16HBE-C1 cells and sera of T-16HBE-C1 cells xenografted nude mice compared with control.	16hbe	82-87	clusterin	Mus musculus	10-13
28784314-4	2017	Levels of CLU and NRP2 were significant elevated in both culture supernatant of T-16HBE-C1 cells and sera of T-16HBE-C1 cells xenografted nude mice compared with control.	16hbe	82-87	neuropilin 2	Mus musculus	18-22