PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33676639-2	2021	To detect NCL we used a modified AS1411 aptamer designated by AS1411-N5.	AGRO 100	33-39	nucleolin	Homo sapiens	10-13
33676639-2	2021	To detect NCL we used a modified AS1411 aptamer designated by AS1411-N5.	AGRO 100	62-68	nucleolin	Homo sapiens	10-13
33692623-5	2021	To enhance the ability of active targeting of this nanoparticle, we modified one side of the DNA nanostructure with aptamer as1411 (As-TDN-R), which can selectively recognize the nucleolin in the cytomembrane of tumor cells.	AGRO 100	124-130	nucleolin	Homo sapiens	179-188
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	98-104	nucleolin	Homo sapiens	5-8
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	98-104	MAX network transcriptional repressor	Homo sapiens	105-108
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	98-104	MAX network transcriptional repressor	Homo sapiens	143-146
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	98-104	MAX network transcriptional repressor	Homo sapiens	143-146
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	98-104	MAX network transcriptional repressor	Homo sapiens	143-146
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	136-142	nucleolin	Homo sapiens	5-8
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	136-142	MAX network transcriptional repressor	Homo sapiens	105-108
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	136-142	MAX network transcriptional repressor	Homo sapiens	143-146
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	136-142	MAX network transcriptional repressor	Homo sapiens	143-146
33548655-4	2021	When NCL passes through the PM nanochannels under a transmembrane voltage bias, it interacts with AS1411-Rox to form G-quadruplexes (G4-AS1411-Rox), resulting in the release of AS1411-Rox from the nanochannels surface and the decrease in PERS signal of the reporter Rox.	AGRO 100	136-142	MAX network transcriptional repressor	Homo sapiens	143-146
33296880-3	2021	In the current study, AS1411 and verapamil (VRP) conjugated bovine serum albumin (BSA) coated AgNPs (AgNPs@BSA-AS-VRP) were synthesized and characterized.	AGRO 100	22-28	albumin	Homo sapiens	67-80
33296880-9	2021	When AgNPs@BSA-AS and AgNPs@BSA-AS-VRP were mixed in a ratio of 19:1, the amount of intracellular nanoparticles increased greatly through AS1411-mediated active targeting and inhibition of P-gp activity.	AGRO 100	138-144	ATP binding cassette subfamily B member 1	Homo sapiens	189-193
33833512-0	2021	Nucleolin-Targeting AS1411 Aptamer-Modified Micelle for the Co-Delivery of Doxorubicin and miR-519c to Improve the Therapeutic Efficacy in Hepatocellular Carcinoma Treatment.	AGRO 100	20-26	nucleolin	Homo sapiens	0-9
33833512-0	2021	Nucleolin-Targeting AS1411 Aptamer-Modified Micelle for the Co-Delivery of Doxorubicin and miR-519c to Improve the Therapeutic Efficacy in Hepatocellular Carcinoma Treatment.	AGRO 100	20-26	microRNA 519c	Homo sapiens	91-99
33833512-3	2021	Materials and Methods: The AS1411 aptamer-functionalized micelles were constructed through an emulsion/solvent evaporation strategy for the simultaneous co-delivery of doxorubicin and miR-519c.	AGRO 100	27-33	microRNA 519c	Homo sapiens	184-192
33833512-5	2021	Results: The micelle was demonstrated to possess favorable cellular uptake and tumor penetration ability by specifically recognizing the nucleolin in an AS1411 aptamer-dependent manner.	AGRO 100	153-159	nucleolin	Homo sapiens	137-146
33586959-5	2021	After selective entry into cancer cells via nucleolin-mediated endocytosis, the overexpressed CTSB in lysosome could cleave Ce6-Pep and trigger the Ce6 moiety dissociation from AS1411-Ce6-CQDs, thus leading to the termination of FRET process, achieving the efficient ratiometric fluorescence response toward endogenous CTSB with a remarkably large emission wavelength shift of ~200 nm from NIR to blue emission region.	AGRO 100	177-183	nucleolin	Homo sapiens	44-53
33690196-2	2021	In this study, AS1411 aptamer-functionalised nucleolin-targeted doxorubicin-loaded lipid nanobubbles (AS1411-DOX-NBs) were constructed, and their physicochemical properties as well as anti-tumour and cardioprotective efficacies were systematically tested and evaluated.	AGRO 100	15-21	nucleolin	Mus musculus	45-54
33161975-1	2020	Taking advantage of the superior biocompatibility, good stability in a wide pH and temperature range, as well as its strong affinity with DNA of hydroxyapatite (HAp), tetrahedral DNA nanostructures (TDNs) conjugated with AS1411 aptamer (anti-nucleolin overexpressed on tumor cell membranes) were employed as affinity ligands to construct a novel mono-dispersed HAp based probe with Gd3+ doping (Apt-TDNs-GdHAp) for MR imaging.	AGRO 100	221-227	nucleolin	Homo sapiens	242-251
33557379-0	2021	Locking up the AS1411 Aptamer with a Flanking Duplex: Towards an Improved Nucleolin-Targeting.	AGRO 100	15-21	nucleolin	Homo sapiens	74-83
33557379-1	2021	We have designed AS1411-N6, a derivative of the nucleolin (NCL)-binding aptamer AS1411, by adding six nucleotides to the 5"-end that are complementary to nucleotides at the 3"-end forcing it into a stem-loop structure.	AGRO 100	17-23	nucleolin	Homo sapiens	48-57
33557379-1	2021	We have designed AS1411-N6, a derivative of the nucleolin (NCL)-binding aptamer AS1411, by adding six nucleotides to the 5"-end that are complementary to nucleotides at the 3"-end forcing it into a stem-loop structure.	AGRO 100	17-23	nucleolin	Homo sapiens	59-62
33188383-7	2020	Molecular analysis revealed that the enhanced anticancer potency was due to the synergic effect induced by the simultaneous activation of p53 by AS1411 and the inhibition of thymidylate synthase by FUdR, respectively, both of which were generated from the DNA nanoparticles.	AGRO 100	145-151	tumor protein p53	Homo sapiens	138-141
33324832-3	2020	In this study, we constructed AS1411 aptamer-based gold nanoparticles with appropriate size facilitating endocytosis and actively targeted drug delivery for gastric cancer cells via the specific AS1411-nucleolin interaction.	AGRO 100	30-36	nucleolin	Mus musculus	202-211
33324832-3	2020	In this study, we constructed AS1411 aptamer-based gold nanoparticles with appropriate size facilitating endocytosis and actively targeted drug delivery for gastric cancer cells via the specific AS1411-nucleolin interaction.	AGRO 100	195-201	nucleolin	Mus musculus	202-211
33586959-5	2021	After selective entry into cancer cells via nucleolin-mediated endocytosis, the overexpressed CTSB in lysosome could cleave Ce6-Pep and trigger the Ce6 moiety dissociation from AS1411-Ce6-CQDs, thus leading to the termination of FRET process, achieving the efficient ratiometric fluorescence response toward endogenous CTSB with a remarkably large emission wavelength shift of ~200 nm from NIR to blue emission region.	AGRO 100	177-183	cathepsin B	Homo sapiens	94-98
33586959-5	2021	After selective entry into cancer cells via nucleolin-mediated endocytosis, the overexpressed CTSB in lysosome could cleave Ce6-Pep and trigger the Ce6 moiety dissociation from AS1411-Ce6-CQDs, thus leading to the termination of FRET process, achieving the efficient ratiometric fluorescence response toward endogenous CTSB with a remarkably large emission wavelength shift of ~200 nm from NIR to blue emission region.	AGRO 100	177-183	progestagen associated endometrial protein	Homo sapiens	128-131
33586959-5	2021	After selective entry into cancer cells via nucleolin-mediated endocytosis, the overexpressed CTSB in lysosome could cleave Ce6-Pep and trigger the Ce6 moiety dissociation from AS1411-Ce6-CQDs, thus leading to the termination of FRET process, achieving the efficient ratiometric fluorescence response toward endogenous CTSB with a remarkably large emission wavelength shift of ~200 nm from NIR to blue emission region.	AGRO 100	177-183	cathepsin B	Homo sapiens	319-323
33586959-6	2021	Notably, the nanoprobe AS1411-Ce6-CQDs exhibited an excellent specificity for ratiometric fluorescent sensing of CTSB activity with an ultralow detection limit of 0.096 ng/mL, demonstrating its promising use for early precise cancer diagnosis in the near future.	AGRO 100	23-29	cathepsin B	Homo sapiens	113-117
33161975-1	2020	Taking advantage of the superior biocompatibility, good stability in a wide pH and temperature range, as well as its strong affinity with DNA of hydroxyapatite (HAp), tetrahedral DNA nanostructures (TDNs) conjugated with AS1411 aptamer (anti-nucleolin overexpressed on tumor cell membranes) were employed as affinity ligands to construct a novel mono-dispersed HAp based probe with Gd3+ doping (Apt-TDNs-GdHAp) for MR imaging.	AGRO 100	221-227	GRDX	Homo sapiens	382-385
32498876-0	2020	Aptamer AS1411 utilized for super-resolution imaging of nucleolin.	AGRO 100	8-14	nucleolin	Homo sapiens	56-65
32882423-9	2020	In addition, tagging the system with AS1411 DNA aptamer facilitated drug uptake into nucleolin positive colorectal cancer cells leading to higher cellular toxicity and apoptosis induction in C26 cells compared to nucleolin-negative CHO cell line.	AGRO 100	37-43	nucleolin	Mus musculus	85-94
32882423-9	2020	In addition, tagging the system with AS1411 DNA aptamer facilitated drug uptake into nucleolin positive colorectal cancer cells leading to higher cellular toxicity and apoptosis induction in C26 cells compared to nucleolin-negative CHO cell line.	AGRO 100	37-43	nucleolin	Mus musculus	213-222
32887113-5	2020	Aptamer AS1411 coupled to the PLNPs-PAMAM surface can specifically bind to the over-expressed nucleolin on the membrane of tumor cells and improve the intracellular accumulation of the nanoparticles.	AGRO 100	8-14	nucleolin	Homo sapiens	94-103
33096752-5	2020	The AS1411 derivatives were characterized by using circular dichroism and nuclear magnetic resonance spectroscopies and then investigated for their enzymatic resistance in serum and nuclear extract, as well as for their ability to bind nucleolin, inhibit topoisomerase I, and affect the viability of MCF-7 human breast adenocarcinoma cells.	AGRO 100	4-10	nucleolin	Homo sapiens	236-245
32447200-5	2020	At the next stage, AS1411 aptamer was conjugated onto the surface of MMP-2 responsive polymersomal formulation in order to provide guided drug delivery against nucleolin positive cells.	AGRO 100	19-25	matrix metallopeptidase 2	Mus musculus	69-74
32447200-5	2020	At the next stage, AS1411 aptamer was conjugated onto the surface of MMP-2 responsive polymersomal formulation in order to provide guided drug delivery against nucleolin positive cells.	AGRO 100	19-25	nucleolin	Mus musculus	160-169
32447200-8	2020	On the other hand, AS1411 aptamer-targeted MMP-2 responsive chimeric polymersomal formulation exhibited highest therapeutic index compared to other groups.	AGRO 100	19-25	matrix metallopeptidase 2	Mus musculus	43-48
32707287-4	2020	AS1411 is a G-quadruplex (G4) aptamer capable of tumor-specific recognition, since it binds to nucleolin, a multi-functional protein expressed in many different types of cancer cells.	AGRO 100	0-6	nucleolin	Mus musculus	95-104
32498876-5	2020	The emergence of aptamer AS1411 provides us a good choice to recognize the NCL without permeabilization owing to its superior cellular uptake and enhanced stability.	AGRO 100	25-31	nucleolin	Homo sapiens	75-78
32498876-6	2020	Therefore, we applied aptamer AS1411 to super-resolution imaging to visualize the distribution of NCL at a nanometer level.	AGRO 100	30-36	nucleolin	Homo sapiens	98-101
32247218-3	2020	The surface of nanofiber substrates was modified with the anti-adhesion molecule, bovine serum albumin (BSA) and the nucleolin aptamer AS1411, wherein, aptamer AS1411 specifically binds to the nucleolin protein overexpressed on the membrane surface of cancer cells.	AGRO 100	135-141	nucleolin	Bos taurus	117-126
32666304-1	2020	PURPOSE: To construct aptamer AS1411-functionalized targeted lipid nanobubbles that could simultaneously target abnormally highly expressed nucleolin (NCL) on tumor tissue and neovasculature.	AGRO 100	30-36	nucleolin	Homo sapiens	140-149
32666304-1	2020	PURPOSE: To construct aptamer AS1411-functionalized targeted lipid nanobubbles that could simultaneously target abnormally highly expressed nucleolin (NCL) on tumor tissue and neovasculature.	AGRO 100	30-36	nucleolin	Homo sapiens	151-154
32247218-3	2020	The surface of nanofiber substrates was modified with the anti-adhesion molecule, bovine serum albumin (BSA) and the nucleolin aptamer AS1411, wherein, aptamer AS1411 specifically binds to the nucleolin protein overexpressed on the membrane surface of cancer cells.	AGRO 100	135-141	nucleolin	Bos taurus	193-202
32247218-3	2020	The surface of nanofiber substrates was modified with the anti-adhesion molecule, bovine serum albumin (BSA) and the nucleolin aptamer AS1411, wherein, aptamer AS1411 specifically binds to the nucleolin protein overexpressed on the membrane surface of cancer cells.	AGRO 100	160-166	nucleolin	Bos taurus	117-126
32247218-3	2020	The surface of nanofiber substrates was modified with the anti-adhesion molecule, bovine serum albumin (BSA) and the nucleolin aptamer AS1411, wherein, aptamer AS1411 specifically binds to the nucleolin protein overexpressed on the membrane surface of cancer cells.	AGRO 100	160-166	nucleolin	Bos taurus	193-202
32437399-8	2020	AS1411 binds nucleolin, which is over-expressed on the surface of cancer cells, and in addition to its tumor-targeting properties AS1411 has also been shown to induce anti-cancer effects.	AGRO 100	0-6	nucleolin	Homo sapiens	13-22
32587339-7	2020	Nucleolin siRNA treatment suppressed midkine-induced EGFR activation in vitro, and nucleolin inhibitor AS1411 suppressed proliferation and migration of PASMC induced by midkine.	AGRO 100	103-109	nucleolin	Homo sapiens	83-92
32587339-7	2020	Nucleolin siRNA treatment suppressed midkine-induced EGFR activation in vitro, and nucleolin inhibitor AS1411 suppressed proliferation and migration of PASMC induced by midkine.	AGRO 100	103-109	midkine	Mus musculus	169-176
32658190-3	2020	AS1411 is specifically bonded with targeted nucleolin receptors on cancer cells so that DOX targets cancer cells instead of healthy cells.	AGRO 100	0-6	nucleolin	Homo sapiens	44-53
32207496-2	2020	Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.	AGRO 100	20-26	nucleolin	Homo sapiens	31-40
31412132-7	2019	Blocking the RNA/DNA binding protein nucleolin with midkine reduced expression of IL-1beta/TNFalpha and the nucleolin inhibitor AS1411 reduced interleukin-6 release in adult mice cardiomyocytes.	AGRO 100	128-134	nucleolin	Mus musculus	37-46
32081668-0	2020	Corneal neovascularization is inhibited with nucleolin-binding aptamer, AS1411.	AGRO 100	72-78	nucleolin	Homo sapiens	45-54
32081668-5	2020	The major goal for this current study is to test the effect of AS1411, a NCL-binding DNA aptamer that has reached human clinical trials, on neovascularization in a murine model of VEGF-mediated CNV.	AGRO 100	63-69	nucleolin	Homo sapiens	73-76
32081668-5	2020	The major goal for this current study is to test the effect of AS1411, a NCL-binding DNA aptamer that has reached human clinical trials, on neovascularization in a murine model of VEGF-mediated CNV.	AGRO 100	63-69	vascular endothelial growth factor A	Mus musculus	180-184
32081668-7	2020	Mechanistic studies indicate that AS1411 reduces the VEGF-stimulated proliferation, migration, and tube formation of primary cells obtained from human limbus stroma (HLSC).	AGRO 100	34-40	vascular endothelial growth factor A	Homo sapiens	53-57
32081668-8	2020	AS1411 treatment also significantly reduced VEGF-stimulated induction of miR-21 and miR-221 in HLSC, suggesting a role for these pro-angiogenic miRNAs in mediating the effects of AS1411 in this system.	AGRO 100	0-6	vascular endothelial growth factor A	Homo sapiens	44-48
32081668-8	2020	AS1411 treatment also significantly reduced VEGF-stimulated induction of miR-21 and miR-221 in HLSC, suggesting a role for these pro-angiogenic miRNAs in mediating the effects of AS1411 in this system.	AGRO 100	0-6	microRNA 21	Homo sapiens	73-79
32081668-8	2020	AS1411 treatment also significantly reduced VEGF-stimulated induction of miR-21 and miR-221 in HLSC, suggesting a role for these pro-angiogenic miRNAs in mediating the effects of AS1411 in this system.	AGRO 100	0-6	microRNA 221	Homo sapiens	84-91
32081668-8	2020	AS1411 treatment also significantly reduced VEGF-stimulated induction of miR-21 and miR-221 in HLSC, suggesting a role for these pro-angiogenic miRNAs in mediating the effects of AS1411 in this system.	AGRO 100	179-185	vascular endothelial growth factor A	Homo sapiens	44-48
31855408-2	2020	Owing to the specific binding of AS1411 to nucleolin, which is overexpressed in tumor cell membranes and nuclei, an AS1411-decorated MB-delivery system leads to dramatically increased cell uptake of MBs for probing survivin mRNA and thus induces strong intracellular fluorescence emission in targeted tumorous cells and cell nuclei.	AGRO 100	33-39	nucleolin	Homo sapiens	43-52
31855408-2	2020	Owing to the specific binding of AS1411 to nucleolin, which is overexpressed in tumor cell membranes and nuclei, an AS1411-decorated MB-delivery system leads to dramatically increased cell uptake of MBs for probing survivin mRNA and thus induces strong intracellular fluorescence emission in targeted tumorous cells and cell nuclei.	AGRO 100	116-122	nucleolin	Homo sapiens	43-52
31412132-7	2019	Blocking the RNA/DNA binding protein nucleolin with midkine reduced expression of IL-1beta/TNFalpha and the nucleolin inhibitor AS1411 reduced interleukin-6 release in adult mice cardiomyocytes.	AGRO 100	128-134	nucleolin	Mus musculus	108-117
31412132-7	2019	Blocking the RNA/DNA binding protein nucleolin with midkine reduced expression of IL-1beta/TNFalpha and the nucleolin inhibitor AS1411 reduced interleukin-6 release in adult mice cardiomyocytes.	AGRO 100	128-134	interleukin 6	Mus musculus	143-156
31465736-6	2019	Furthermore, AS1411/SKN&DTX-M showed a strong inhibition against the formation of cancer stem cell-enriched U87 cell spheroids, in which the expression of CD133 was downregulated significantly.	AGRO 100	13-19	prominin 1	Mus musculus	159-164
31349496-2	2019	Functionalization of nanocapsules with AS1411 aptamer will enhance their recognition by tumor cells, due to the interaction with nucleolin, and subsequent endocytosis.	AGRO 100	39-45	nucleolin	Homo sapiens	129-138
31218573-7	2019	The nucleolin-blocking experiments unambiguously evidenced that the formed nanomedicine could target to the cell surface via the specific AS1411-nucleolin interaction, which increased the efficiency of cell uptake.	AGRO 100	138-144	nucleolin	Mus musculus	4-13
31336175-0	2019	AS1411-conjugated gold nanoparticles affect cell proliferation through a mechanism that seems independent of nucleolin.	AGRO 100	0-6	nucleolin	Homo sapiens	109-118
31336175-1	2019	G-rich oligonucleotide, AS1411, has been shown to interact with nucleolin and to inhibit cancer cell proliferation and tumor growth.	AGRO 100	24-30	nucleolin	Homo sapiens	64-73
31336175-4	2019	In this work, we show in several cell lines that optimized AS1411-conjugated gold nanoparticles (GNS-AS1411) inhibit nucleolin expression at the RNA and protein levels.	AGRO 100	59-65	nucleolin	Homo sapiens	117-126
31336175-4	2019	In this work, we show in several cell lines that optimized AS1411-conjugated gold nanoparticles (GNS-AS1411) inhibit nucleolin expression at the RNA and protein levels.	AGRO 100	101-107	nucleolin	Homo sapiens	117-126
31301466-4	2019	Herein, we have studied two quadruplex-forming DNA sequences derived from the nucleolin-targeted aptamer AS1411 as supramolecular carriers for the cancer-selective delivery of acridine orange derivatives (C3, C5 and C8) in cervical cancer cells.	AGRO 100	105-111	nucleolin	Mus musculus	78-87
31218573-7	2019	The nucleolin-blocking experiments unambiguously evidenced that the formed nanomedicine could target to the cell surface via the specific AS1411-nucleolin interaction, which increased the efficiency of cell uptake.	AGRO 100	138-144	nucleolin	Mus musculus	145-154
30241804-0	2018	Glutathione responsive chitosan-thiolated dextran conjugated miR-145 nanoparticles targeted with AS1411 aptamer for cancer treatment.	AGRO 100	97-103	microRNA 145	Homo sapiens	61-68
31072423-6	2019	Therefore, the simultaneous delivery of PTX and PLK1-targeted siRNA using AS1411 aptamer-functionalized liposome may have good potential clinical value for the therapy of breast cancer.	AGRO 100	74-80	polo like kinase 1	Homo sapiens	48-52
30731350-2	2019	In this immunosensor, the nucleolin-targeting aptamer AS1411 (CP) was used to specifically capture tumor cells, and a TSA-based signal enhancement system consisting of Pt NPs@HRP@CP composite as catalytic probe and tyramine functionalized infinite coordination polymer (ICPs@Tyr) as electroactive signal tag was applied to improve the detection sensitivity.	AGRO 100	54-60	nucleolin	Homo sapiens	26-35
32255035-6	2018	Further assembly of nucleolin-specific AS1411 aptamers conferred the nanosystem with target-specific recognition and accumulation abilities.	AGRO 100	39-45	nucleolin	Homo sapiens	20-29
30926271-1	2019	AS1411 is a 26-mer G-rich DNA aptamer which has been broadly employed in the field of targeted drug delivery, due to its capability to bind to nucleolin protein on the surface of cancer cells.	AGRO 100	0-6	nucleolin	Homo sapiens	143-152
30926271-2	2019	In this work, it has been shown for the first time that in addition to nucleolin, AS1411 aptamer could bind to copper ions (Cu2+) with high affinity and selectivity, affecting AS1411 usage in drug delivery systems as a targeting agent.	AGRO 100	176-182	nucleolin	Homo sapiens	71-80
30650243-3	2019	AS1411 is a DNA aptamer with high specificity and affinity for nucleolin and could integrate into liposomes by the modification of cholesterol.	AGRO 100	0-6	nucleolin	Homo sapiens	63-72
30650243-4	2019	The bispecific alpha-Gal liposomes surface-functionalized by alpha-Gal and AS1411 aptamer could recognize anti-Gal antibodies and nucleolin overexpressed by tumor cells simultaneously, followed by activating the immune system to attack the tumor cells, resulting in the lysis of the tumor cells by antibody dependent cell-mediated cytotoxicity.	AGRO 100	75-81	nucleolin	Homo sapiens	130-139
30650243-6	2019	This study suggests that the AS1411 modified alpha-Gal liposomes can recognize nucleolin-overexpressing tumor cells selectively, subsequently improve the effect of the immunotherapy with high specificity.	AGRO 100	29-35	nucleolin	Homo sapiens	79-88
30924334-2	2019	Here, we modified the DNA tetrahedron with a DNA aptamer (AS1411) as a DNA-based delivery system, which could bind to nucleolin for its cancer cell selectivity.	AGRO 100	58-64	nucleolin	Homo sapiens	118-127
30841428-3	2019	A selected aptamer - AS1411 - selective towards nucleolin, with a terminal thiol group was conjugated to HGNs.	AGRO 100	21-27	nucleolin	Homo sapiens	48-57
30241804-5	2018	Also, polyelectrolyte complexes (PECs) of TD-miR and chitosan were fabricated and decorated with anti nucleolin aptamer, AS1411 (apt-PEC).	AGRO 100	121-127	membrane associated ring-CH-type finger 8	Homo sapiens	45-48
30092457-2	2018	For sensitive and selective detection, the anodic pole of the bipolar electrode was modified with the AS1411 aptamer, a specific aptamer for the nucleolin, and treated by the secondary aptamer modified gold nanoparticles.	AGRO 100	102-108	nucleolin	Homo sapiens	145-154
30303006-6	2018	By further modifying with the nucleolin-targeting aptamer AS1411, this polymeric SNA could be specifically internalized into the tumor cells through nucleolin-mediated endocytosis and then interact with endogenous ATP to cause the release of therapeutics agents from long DNA concatamer via a structure switching, leading to the activation of the fluorescence and selective synergistic chemotherapy and photodynamic therapy.	AGRO 100	58-64	nucleolin	Homo sapiens	30-39
30303006-6	2018	By further modifying with the nucleolin-targeting aptamer AS1411, this polymeric SNA could be specifically internalized into the tumor cells through nucleolin-mediated endocytosis and then interact with endogenous ATP to cause the release of therapeutics agents from long DNA concatamer via a structure switching, leading to the activation of the fluorescence and selective synergistic chemotherapy and photodynamic therapy.	AGRO 100	58-64	nucleolin	Homo sapiens	149-158
30394201-2	2018	METHODS: AS1411 antinucleolin aptamer-decorated PEGylated poly(lactic-co-glycolic acid) nanoparticles containing CIS (Ap-CIS-NPs) and anti-miR-21 (Ap-anti-miR-21-NPs) were prepared, physicochemically investigated and their cancer-targeting ability was confirmed.	AGRO 100	9-15	microRNA 21	Homo sapiens	155-161
30464179-9	2018	We confirmed this by showing inhibition of cell proliferation in some pre-B ALLs by exposure to a NCL-specific aptamer AS1411.	AGRO 100	119-125	nucleolin	Homo sapiens	98-101
30303384-5	2018	Meanwhile, the inhibition of antiapoptotic protein B-cell lymphoma 2 (Bcl-2) expression by AS1411 allows for greatly improved PDT-induced cell apoptosis.	AGRO 100	91-97	BCL2 apoptosis regulator	Homo sapiens	51-68
30303384-5	2018	Meanwhile, the inhibition of antiapoptotic protein B-cell lymphoma 2 (Bcl-2) expression by AS1411 allows for greatly improved PDT-induced cell apoptosis.	AGRO 100	91-97	BCL2 apoptosis regulator	Homo sapiens	70-75
30568710-2	2018	AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect.	AGRO 100	0-6	nucleolin	Homo sapiens	57-66
30170359-1	2018	AS1411 is a nucleolin-binding aptamer which attracted great interest as active targeting ligand for the selective delivery of therapeutic agents to tumour cells.	AGRO 100	0-6	nucleolin	Homo sapiens	12-21
29864441-4	2018	A nucleolin binding aptamer, AS1411, was biotinylated and complexed with traptavidin and utilized as a platform for the delivery of GFP or X-linked inhibitor of apoptosis (XIAP) proteins by intravitreal injection in BALB/c mice.	AGRO 100	29-35	X-linked inhibitor of apoptosis	Mus musculus	139-170
29864441-4	2018	A nucleolin binding aptamer, AS1411, was biotinylated and complexed with traptavidin and utilized as a platform for the delivery of GFP or X-linked inhibitor of apoptosis (XIAP) proteins by intravitreal injection in BALB/c mice.	AGRO 100	29-35	X-linked inhibitor of apoptosis	Mus musculus	172-176
29864441-8	2018	Intravitreal injection of AS1411-directed GFP or XIAP complexes enabled delivery of these proteins into ganglion cells, photoreceptors and retinal pigment epithelium in vivo.	AGRO 100	26-32	X-linked inhibitor of apoptosis	Mus musculus	49-53
29864441-10	2018	A concomitant decrease in activity of Caspase 3/7 was observed in eyes injected with the AS1411-XIAP complex.	AGRO 100	89-95	caspase 3	Mus musculus	38-47
29864441-10	2018	A concomitant decrease in activity of Caspase 3/7 was observed in eyes injected with the AS1411-XIAP complex.	AGRO 100	89-95	X-linked inhibitor of apoptosis	Mus musculus	96-100
29325460-0	2018	Targeted delivery of melittin to cancer cells by AS1411 anti-nucleolin aptamer.	AGRO 100	49-55	melittin	Apis mellifera	21-29
29617556-3	2018	The CRISPR-Cas9 plasmid for CDK11 knockout was encapsulated in the core of the delivery system composed of protamine sulfate, calcium carbonate, and calcium phosphate by coprecipitation, and functional derivatives of carboxymethyl chitosan (biotinylated carboxymethyl chitosan with biotin ligands and aptamer-incorporated carboxymethyl chitosan with AS1411 ligands) were decorated on the nanovector surface by electrostatic interactions to form the dual-targeting delivery system.	AGRO 100	350-356	cyclin dependent kinase 11B	Homo sapiens	28-33
29617556-4	2018	On the basis of the tumor cell targeting capability of biotin and AS1411 ligands as well as the nuclear targeting of AS1411, the dual-targeting system can deliver the CRISPR-Cas9 plasmid into the nuclei of tumor cells to realize highly efficient genome editing, resulting in a dramatic decrease (>90%) in CDK11 protein together with the significant downregulation of other proteins involved in tumor development, including an ~90% decrease in MMP-9, >40% decrease in VEGF, and ~70% decrease in survivin.	AGRO 100	66-72	cyclin dependent kinase 11B	Homo sapiens	308-313
29617556-4	2018	On the basis of the tumor cell targeting capability of biotin and AS1411 ligands as well as the nuclear targeting of AS1411, the dual-targeting system can deliver the CRISPR-Cas9 plasmid into the nuclei of tumor cells to realize highly efficient genome editing, resulting in a dramatic decrease (>90%) in CDK11 protein together with the significant downregulation of other proteins involved in tumor development, including an ~90% decrease in MMP-9, >40% decrease in VEGF, and ~70% decrease in survivin.	AGRO 100	66-72	matrix metallopeptidase 9	Homo sapiens	446-451
29617556-4	2018	On the basis of the tumor cell targeting capability of biotin and AS1411 ligands as well as the nuclear targeting of AS1411, the dual-targeting system can deliver the CRISPR-Cas9 plasmid into the nuclei of tumor cells to realize highly efficient genome editing, resulting in a dramatic decrease (>90%) in CDK11 protein together with the significant downregulation of other proteins involved in tumor development, including an ~90% decrease in MMP-9, >40% decrease in VEGF, and ~70% decrease in survivin.	AGRO 100	66-72	vascular endothelial growth factor A	Homo sapiens	473-477
29617556-4	2018	On the basis of the tumor cell targeting capability of biotin and AS1411 ligands as well as the nuclear targeting of AS1411, the dual-targeting system can deliver the CRISPR-Cas9 plasmid into the nuclei of tumor cells to realize highly efficient genome editing, resulting in a dramatic decrease (>90%) in CDK11 protein together with the significant downregulation of other proteins involved in tumor development, including an ~90% decrease in MMP-9, >40% decrease in VEGF, and ~70% decrease in survivin.	AGRO 100	117-123	cyclin dependent kinase 11B	Homo sapiens	308-313
29617556-4	2018	On the basis of the tumor cell targeting capability of biotin and AS1411 ligands as well as the nuclear targeting of AS1411, the dual-targeting system can deliver the CRISPR-Cas9 plasmid into the nuclei of tumor cells to realize highly efficient genome editing, resulting in a dramatic decrease (>90%) in CDK11 protein together with the significant downregulation of other proteins involved in tumor development, including an ~90% decrease in MMP-9, >40% decrease in VEGF, and ~70% decrease in survivin.	AGRO 100	117-123	matrix metallopeptidase 9	Homo sapiens	446-451
29617556-4	2018	On the basis of the tumor cell targeting capability of biotin and AS1411 ligands as well as the nuclear targeting of AS1411, the dual-targeting system can deliver the CRISPR-Cas9 plasmid into the nuclei of tumor cells to realize highly efficient genome editing, resulting in a dramatic decrease (>90%) in CDK11 protein together with the significant downregulation of other proteins involved in tumor development, including an ~90% decrease in MMP-9, >40% decrease in VEGF, and ~70% decrease in survivin.	AGRO 100	117-123	vascular endothelial growth factor A	Homo sapiens	473-477
29554483-3	2018	Here, we demonstrated NCL/miR-221/NFkappaB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFkappaB/DNMT1 signaling pathway in AML.	AGRO 100	285-291	nucleolin	Homo sapiens	22-25
29554483-3	2018	Here, we demonstrated NCL/miR-221/NFkappaB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFkappaB/DNMT1 signaling pathway in AML.	AGRO 100	285-291	microRNA 221	Homo sapiens	26-33
29554483-3	2018	Here, we demonstrated NCL/miR-221/NFkappaB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFkappaB/DNMT1 signaling pathway in AML.	AGRO 100	285-291	nuclear factor kappa B subunit 1	Homo sapiens	34-42
29554483-3	2018	Here, we demonstrated NCL/miR-221/NFkappaB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFkappaB/DNMT1 signaling pathway in AML.	AGRO 100	285-291	DNA methyltransferase 1	Homo sapiens	43-48
29554483-3	2018	Here, we demonstrated NCL/miR-221/NFkappaB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFkappaB/DNMT1 signaling pathway in AML.	AGRO 100	285-291	nucleolin	Homo sapiens	342-345
29554483-3	2018	Here, we demonstrated NCL/miR-221/NFkappaB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFkappaB/DNMT1 signaling pathway in AML.	AGRO 100	285-291	microRNA 221	Homo sapiens	346-353
29554483-3	2018	Here, we demonstrated NCL/miR-221/NFkappaB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFkappaB/DNMT1 signaling pathway in AML.	AGRO 100	285-291	nuclear factor kappa B subunit 1	Homo sapiens	354-362
29554483-3	2018	Here, we demonstrated NCL/miR-221/NFkappaB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFkappaB/DNMT1 signaling pathway in AML.	AGRO 100	285-291	DNA methyltransferase 1	Homo sapiens	363-368
29325460-0	2018	Targeted delivery of melittin to cancer cells by AS1411 anti-nucleolin aptamer.	AGRO 100	49-55	nucleolin	Mus musculus	61-70
29325460-4	2018	Melittin was covalently attached to antinucleolin aptamer (AS1411) and its toxicity in A549 (nucleolin positive) and L929 (nucleolin negative) was studied using MTT and Annexin V flow cytometry methods.	AGRO 100	59-65	melittin	Apis mellifera	0-8
29325460-4	2018	Melittin was covalently attached to antinucleolin aptamer (AS1411) and its toxicity in A549 (nucleolin positive) and L929 (nucleolin negative) was studied using MTT and Annexin V flow cytometry methods.	AGRO 100	59-65	nucleolin	Mus musculus	40-49
29669200-3	2018	The three-way junction pocket DNA nanostructure is composed of three strands of AS1411 aptamer as both a therapeutic aptamer and nucleolin target, the potential biomarker of prostate (PC-3 cells) and breast (4T1 cells) cancers.	AGRO 100	80-86	nucleolin	Mus musculus	129-138
29465130-4	2018	In addition, the VEGF aptamer locking units were conjugated to the AS1411 aptamer sequence that binds to nucleolin receptors associated with cancer cells, resulting in the construction of cancer-cell targeted VEGF-responsive doxorubicin-loaded NMOFs.	AGRO 100	67-73	vascular endothelial growth factor A	Homo sapiens	17-21
29465130-4	2018	In addition, the VEGF aptamer locking units were conjugated to the AS1411 aptamer sequence that binds to nucleolin receptors associated with cancer cells, resulting in the construction of cancer-cell targeted VEGF-responsive doxorubicin-loaded NMOFs.	AGRO 100	67-73	vascular endothelial growth factor A	Homo sapiens	209-213
30396283-0	2018	Nucleolin Overexpression Confers Increased Sensitivity to the Anti-Nucleolin Aptamer, AS1411.	AGRO 100	86-92	nucleolin	Homo sapiens	0-9
28690315-9	2018	Moreover, combining nucleolin inhibitors: aptamer AS1411 or nucant N6L with doxorubicin reduced DLBCL cell survival.	AGRO 100	50-56	nucleolin	Homo sapiens	20-29
29310244-5	2018	Subsequently, after internalizing into cells, AS1411 aptamer moiety of nanocarrier bound to nucleolin selectively, then the whole nanocarrier targeted nucleus and released Dox into nucleus.	AGRO 100	46-52	nucleolin	Homo sapiens	92-101
29310244-7	2018	Versus free Dox, Dox-loaded MUC1-Td-AS1411 showed lower cytotoxicity to MUC1-negative HL-7702 cells (P < 0.01), approximately equal lethality to sensitive MCF-7 cells (P > 0.05) whereas more effective to doxorubicin-resistant MCF-7 cells (P < 0.01).	AGRO 100	36-42	mucin 1, cell surface associated	Homo sapiens	28-32
29310244-7	2018	Versus free Dox, Dox-loaded MUC1-Td-AS1411 showed lower cytotoxicity to MUC1-negative HL-7702 cells (P < 0.01), approximately equal lethality to sensitive MCF-7 cells (P > 0.05) whereas more effective to doxorubicin-resistant MCF-7 cells (P < 0.01).	AGRO 100	36-42	mucin 1, cell surface associated	Homo sapiens	72-76
29594749-2	2018	By taking advantage of the high affinity and specificity of the AS1411 aptamer for nucleolin, a signalling probe displacement electrochemical aptasensor was developed.	AGRO 100	64-70	nucleolin	Homo sapiens	83-92
29594749-9	2018	Graphical abstract HApNR-AuNP-AS1411 aptamer nanocomposite as an electrochemical sensing interface was immobilized on the gold electrode surface and conjugated to signaling c-DNA tagged with AgNPs for determination of surface nucleolin on MCF7 cancer cells.	AGRO 100	30-36	nucleolin	Homo sapiens	226-235
29250957-0	2018	Nucleolin-Targeting AS1411-Aptamer-Modified Graft Polymeric Micelle with Dual pH/Redox Sensitivity Designed To Enhance Tumor Therapy through the Codelivery of Doxorubicin/TLR4 siRNA and Suppression of Invasion.	AGRO 100	20-26	nucleolin	Mus musculus	0-9
29250957-0	2018	Nucleolin-Targeting AS1411-Aptamer-Modified Graft Polymeric Micelle with Dual pH/Redox Sensitivity Designed To Enhance Tumor Therapy through the Codelivery of Doxorubicin/TLR4 siRNA and Suppression of Invasion.	AGRO 100	20-26	toll-like receptor 4	Mus musculus	171-175
29352243-5	2018	The effect of the nucleolin-specific inhibitor GroA (AS1411) on ErbB2-positive breast cancer was tested in vivo, in a mouse xenograft model for breast cancer; as well as in vitro, alone and in combination with the ErbB2 kinase-inhibitor tyrphostin AG-825.	AGRO 100	53-59	nucleolin	Homo sapiens	18-27
29352243-5	2018	The effect of the nucleolin-specific inhibitor GroA (AS1411) on ErbB2-positive breast cancer was tested in vivo, in a mouse xenograft model for breast cancer; as well as in vitro, alone and in combination with the ErbB2 kinase-inhibitor tyrphostin AG-825.	AGRO 100	53-59	C-X-C motif chemokine ligand 1	Homo sapiens	47-51
29352243-5	2018	The effect of the nucleolin-specific inhibitor GroA (AS1411) on ErbB2-positive breast cancer was tested in vivo, in a mouse xenograft model for breast cancer; as well as in vitro, alone and in combination with the ErbB2 kinase-inhibitor tyrphostin AG-825.	AGRO 100	53-59	erb-b2 receptor tyrosine kinase 2	Mus musculus	64-69
30396283-0	2018	Nucleolin Overexpression Confers Increased Sensitivity to the Anti-Nucleolin Aptamer, AS1411.	AGRO 100	86-92	nucleolin	Homo sapiens	67-76
30396283-1	2018	AS1411 is an antiproliferative DNA aptamer, which binds the ubiquitous protein, nucleolin.	AGRO 100	0-6	nucleolin	Homo sapiens	80-89
30396283-2	2018	In this study, we show that constitutive overexpression of nucleolin confers increased sensitivity to the growth inhibitory effects of AS1411.	AGRO 100	135-141	nucleolin	Homo sapiens	59-68
30396283-4	2018	Nucleolin overexpressing cells demonstrate increased growth inhibition in response to the AS1411 treatment, which correlates with increased apoptosis and cell cycle arrest, when compared to non-transfected cells.	AGRO 100	90-96	nucleolin	Homo sapiens	0-9
30396283-5	2018	AS1411 induces nucleolin expression at the RNA and protein level in HeLa cells, suggesting a feedback loop with important implications for the clinical use of AS1411.	AGRO 100	0-6	nucleolin	Homo sapiens	15-24
30396283-5	2018	AS1411 induces nucleolin expression at the RNA and protein level in HeLa cells, suggesting a feedback loop with important implications for the clinical use of AS1411.	AGRO 100	159-165	nucleolin	Homo sapiens	15-24
29192701-3	2017	To achieve selective cancer cell targeting, complex 2 was covalently conjugated to aptamer AS1411, a DNA aptamer with strong binding affinity for nucleolin.	AGRO 100	91-97	nucleolin	Homo sapiens	146-155
28989617-7	2017	The AS1411 aptamer is conjugated to the locking units as the targeting unit for the nucleolin biomarker present in cancer cells.	AGRO 100	4-10	nucleolin	Homo sapiens	84-93
29246300-4	2017	They stabilized the G-quadruplex, remained highly resistant to serum degradation and specificity for nucleolin, further inhibited tumor cell growth, exhibited a stronger ability to influence the different phases of the tumor cell cycle, induced S-phase arrest, promoted the inhibition of DNA replication, and suppressed the unwound function of a large T antigen as powerful as AS1411.	AGRO 100	377-383	nucleolin	Homo sapiens	101-110
29246300-7	2017	The computational results further proved that FCL-II exhibits more structural advantages than AS1411 for binding to the target protein nucleolin, indicating its great potential in antitumor therapy.	AGRO 100	94-100	nucleolin	Homo sapiens	135-144
32264606-3	2017	The as-prepared AuNP@(AS1411-AgNCs)n nanocomposite shows strong near-infrared fluorescence emission and improved biostability, and carries a high density of AS1411-the first anticancer aptamer targeting nucleolin protein, which is over-expressed not only on the surface but also in the cytoplasm of cancer cells.	AGRO 100	22-28	nucleolin	Homo sapiens	203-212
32264606-4	2017	The synergy of multivalent AS1411-nucleolin binding promotes accumulation of the nanocomposite towards cancer cells and subsequent internalization in them.	AGRO 100	27-33	nucleolin	Homo sapiens	34-43
28991436-4	2017	AS1411 can specifically bind to nucleolin, which is overexpressed on the cell membrane of tumor cells.	AGRO 100	0-6	nucleolin	Homo sapiens	32-41
28991436-5	2017	Furthermore, AS1411 can inhibit NF-kappaB signaling and reduce the expression of bcl-2.	AGRO 100	13-19	BCL2 apoptosis regulator	Homo sapiens	81-86
28925950-2	2017	We studied the effects of re-purposing AS1411, an anti-cancer compound that binds cell surface NCL, as a possible novel strategy for RSV therapy in vitro and in vivo.	AGRO 100	39-45	nucleolin	Rattus norvegicus	95-98
28925950-5	2017	Intranasal administration of AS1411 (50 mg/kg) to RSV-infected mice and cotton rats was associated with partial reductions in lung viral titers, decreased virus-associated airway inflammation, and decreased IL-4/IFN-gamma ratios when compared to untreated, infected animals.	AGRO 100	29-35	interleukin 4	Rattus norvegicus	207-211
28925950-5	2017	Intranasal administration of AS1411 (50 mg/kg) to RSV-infected mice and cotton rats was associated with partial reductions in lung viral titers, decreased virus-associated airway inflammation, and decreased IL-4/IFN-gamma ratios when compared to untreated, infected animals.	AGRO 100	29-35	interferon gamma	Rattus norvegicus	212-221
28874822-2	2017	AS1411, a nucleolin aptamer, is wrapped around water-soluble carbon dots and used as a probe for the detection of several types of cancer cells.	AGRO 100	0-6	nucleolin	Homo sapiens	10-19
29071183-6	2017	The high density of AS1411-Au NPs on the surface of Au@PC NP enhances multivalent binding with nucleolin molecules on tumor cell membranes.	AGRO 100	20-26	nucleolin	Homo sapiens	95-104
28007579-7	2017	The mechanism underlying the cancer-targeting ability of AS1411 is not completely understood, but recent studies suggest a model that involves: (1) initial uptake by macropinocytosis, a form of endocytosis prevalent in cancer cells; (2) stimulation of macropinocytosis by a nucleolin-dependent mechanism resulting in further uptake; and (3) disruption of nucleolin-mediated trafficking and efflux leading to cargoes becoming trapped inside cancer cells.	AGRO 100	57-63	nucleolin	Homo sapiens	274-283
28007579-7	2017	The mechanism underlying the cancer-targeting ability of AS1411 is not completely understood, but recent studies suggest a model that involves: (1) initial uptake by macropinocytosis, a form of endocytosis prevalent in cancer cells; (2) stimulation of macropinocytosis by a nucleolin-dependent mechanism resulting in further uptake; and (3) disruption of nucleolin-mediated trafficking and efflux leading to cargoes becoming trapped inside cancer cells.	AGRO 100	57-63	nucleolin	Homo sapiens	355-364
28435471-5	2017	Tumor targeting was facilitated via AS1411 binding to nucleolin, which is highly expressed on the surface membrane of breast cancer cells.	AGRO 100	36-42	nucleolin	Homo sapiens	54-63
28248078-4	2017	The efficient interaction of AS1411 and the relevant receptor nucleolin caused the disintegration of the negative-charged AS1411 surface.	AGRO 100	29-35	nucleolin	Homo sapiens	62-71
28248078-4	2017	The efficient interaction of AS1411 and the relevant receptor nucleolin caused the disintegration of the negative-charged AS1411 surface.	AGRO 100	122-128	nucleolin	Homo sapiens	62-71
28248078-6	2017	On the basis of this synergistic effect, the UnTHCPSi-PEI-MTX@AS1411 (hydrodynamic diameter is 242 nm) were efficiently internalized by nucleolin-positive MDA-MB-231 breast cancer cells, with an efficiency around 5.8 times higher than that of nucleolin-negative cells (NIH 3T3 fibroblasts).	AGRO 100	62-68	nucleolin	Homo sapiens	136-145
28248078-6	2017	On the basis of this synergistic effect, the UnTHCPSi-PEI-MTX@AS1411 (hydrodynamic diameter is 242 nm) were efficiently internalized by nucleolin-positive MDA-MB-231 breast cancer cells, with an efficiency around 5.8 times higher than that of nucleolin-negative cells (NIH 3T3 fibroblasts).	AGRO 100	62-68	nucleolin	Homo sapiens	243-252
27840158-3	2017	The SWNT-PEG-PEI conjugate was covalently attached to AS1411 aptamer as the nucleolin ligand to target the co-delivery system to the tumor cells overexpressing nucleolin receptors on their surface.	AGRO 100	54-60	nucleolin	Homo sapiens	76-85
28126548-1	2017	In the current study camptothecin-loaded pegylated PAMAM dendrimer were synthesized and were functionalized with AS1411 anti-nucleolin aptamers for site-specific targeting against colorectal cancer cells which over expresses nucleolin receptors.	AGRO 100	113-119	nucleolin	Mus musculus	125-134
27988470-4	2017	The receptor nucleolin, highly expressed in glioblastoma U87 MG cells as well as neo-vascular endothelial cells, mediated the binding and endocytosis of AS1411-PGG-PTX nanoconjugates, leading to significantly enhanced uptake of AS1411-PGG-PTX nanoconjugates by tumor cells and three-dimension tumor spheroids, and intensive pro-apoptosis effect of AS1411-PGG-PTX nanoconjugates.	AGRO 100	153-159	nucleolin	Homo sapiens	13-22
27840158-3	2017	The SWNT-PEG-PEI conjugate was covalently attached to AS1411 aptamer as the nucleolin ligand to target the co-delivery system to the tumor cells overexpressing nucleolin receptors on their surface.	AGRO 100	54-60	nucleolin	Homo sapiens	160-169
28685471-3	2017	Aptamer AS1411 is known to be an excellent target for nucleolin and also known to treat several cancer types; and MMP-14 in cancer is involved in tumor angiogenesis, blood vessel re-organization, and metastasis.	AGRO 100	8-14	nucleolin	Homo sapiens	54-63
28685471-4	2017	In the proposed agent, AS1411 is selected as the cancer targeting molecule; and the unique property of GNPs of modulating fluorescence are utilized to allow the agent to trigger its fluorescence upon reacting with MMP-14, at an enhanced fluorescence level.	AGRO 100	23-29	matrix metallopeptidase 14	Homo sapiens	214-220
28685471-7	2017	In addition, successful conjugation of the nucleolin target AS1411 onto the GNP was confirmed and among the GNPs size range 5-30 nm tested, 10 nm GNPs showed the highest X-ray/CT enhancement.	AGRO 100	60-66	nucleolin	Homo sapiens	43-52
27907160-3	2016	Here we report that AS1411 induces cell apoptosis and cycle arrest, and inhibits cell viability by up-regulation of p53 and down-regulation of Bcl-2 and Akt1 in human glioma cells.	AGRO 100	20-26	AKT serine/threonine kinase 1	Homo sapiens	153-157
27907160-6	2016	Moreover, AS1411 treatment resulted in the G2/M cell cycle arrest in glioma cells, which was however abolished by overexpression of NCL.	AGRO 100	10-16	nucleolin	Homo sapiens	132-135
27907160-0	2016	AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin.	AGRO 100	0-6	tumor protein p53	Homo sapiens	69-72
27907160-0	2016	AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin.	AGRO 100	0-6	BCL2 apoptosis regulator	Homo sapiens	96-101
27907160-0	2016	AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin.	AGRO 100	0-6	AKT serine/threonine kinase 1	Homo sapiens	106-110
27907160-7	2016	Further, AS1411 induced cell apoptosis, which was prevented by silencing of p53 and overexpression of Bcl-2.	AGRO 100	9-15	tumor protein p53	Homo sapiens	76-79
27907160-0	2016	AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin.	AGRO 100	0-6	nucleolin	Homo sapiens	115-124
27907160-1	2016	AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers.	AGRO 100	0-6	nucleolin	Homo sapiens	13-22
27907160-1	2016	AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers.	AGRO 100	0-6	nucleolin	Homo sapiens	24-27
27907160-7	2016	Further, AS1411 induced cell apoptosis, which was prevented by silencing of p53 and overexpression of Bcl-2.	AGRO 100	9-15	BCL2 apoptosis regulator	Homo sapiens	102-107
27907160-3	2016	Here we report that AS1411 induces cell apoptosis and cycle arrest, and inhibits cell viability by up-regulation of p53 and down-regulation of Bcl-2 and Akt1 in human glioma cells.	AGRO 100	20-26	tumor protein p53	Homo sapiens	116-119
27907160-3	2016	Here we report that AS1411 induces cell apoptosis and cycle arrest, and inhibits cell viability by up-regulation of p53 and down-regulation of Bcl-2 and Akt1 in human glioma cells.	AGRO 100	20-26	BCL2 apoptosis regulator	Homo sapiens	143-148
27907160-8	2016	In addition, AS1411 inhibited the migration and invasion of glioma cells in an Akt1-dependent manner.	AGRO 100	13-19	AKT serine/threonine kinase 1	Homo sapiens	79-83
27399849-5	2016	Treatment with the nucleolin inhibitor GroA (AS1411) prevented these effects in vitro and in vivo.	AGRO 100	45-51	nucleolin	Homo sapiens	19-28
28028501-3	2016	In this study, AS1411 aptamer was conjugated to Fe3O4@Au nanoparticles for specific targeting of mouse mammary carcinoma (4T1) cells that overexpress nucleolin.	AGRO 100	15-21	nucleolin	Mus musculus	150-159
27399849-5	2016	Treatment with the nucleolin inhibitor GroA (AS1411) prevented these effects in vitro and in vivo.	AGRO 100	45-51	C-X-C motif chemokine ligand 1	Homo sapiens	39-43
26859550-1	2016	AS1411 is a g-quadruplex-forming aptamer capable of selectively entering cancer cells by nucleolin receptor-mediated uptake.	AGRO 100	0-6	nucleolin	Homo sapiens	89-98
27494117-0	2016	Modified AS1411 Aptamer Suppresses Hepatocellular Carcinoma by Up-Regulating Galectin-14.	AGRO 100	9-15	galectin 14	Homo sapiens	77-88
27494117-2	2016	AS1411 is an aptamer that binds to nucleolin, which is overexpressed in the cytoplasm and occurs on the surface of cancer cells.	AGRO 100	0-6	nucleolin	Homo sapiens	35-44
27494117-11	2016	In a microarray, AS1411 significantly enhanced galectin-14 expression.	AGRO 100	17-23	galectin 14	Homo sapiens	47-58
27494117-13	2016	Modified AS1411-aptamer suppressed HCC cell growth in vitro and in vivo by up-regulating galectin-14 expressions.	AGRO 100	9-15	galectin 14	Homo sapiens	89-100
26840019-4	2016	Herein we successfully achieved targeting CPC cells and avoiding exposure to healthy tissues for TP by nucleolin-specific aptamer (AS1411) mediated polymeric nanocarrier.	AGRO 100	131-137	nucleolin	Homo sapiens	103-112
27194215-2	2016	In this study, we performed chemical modification of 2"-deoxyinosine in AS1411, an anti-proliferative G-rich oligodeoxynucleotide aptamer, which binds selectively to the nucleolin protein.	AGRO 100	72-78	nucleolin	Homo sapiens	170-179
27194215-7	2016	Structural investigations of the FAN-1524dI/nucleolin complex structure, using molecular dynamics simulation, revealed the critical interactions involving nucleolin and 2"-dI incorporated AS1411 compared with AS1411 alone.	AGRO 100	188-194	nucleolin	Homo sapiens	44-53
27194215-7	2016	Structural investigations of the FAN-1524dI/nucleolin complex structure, using molecular dynamics simulation, revealed the critical interactions involving nucleolin and 2"-dI incorporated AS1411 compared with AS1411 alone.	AGRO 100	209-215	nucleolin	Homo sapiens	44-53
27194215-7	2016	Structural investigations of the FAN-1524dI/nucleolin complex structure, using molecular dynamics simulation, revealed the critical interactions involving nucleolin and 2"-dI incorporated AS1411 compared with AS1411 alone.	AGRO 100	209-215	nucleolin	Homo sapiens	155-164
26923800-7	2016	AS1411 is a G-quartet aptamer capable of targeting nucleolin.	AGRO 100	0-6	nucleolin	Homo sapiens	51-60
26923800-11	2016	Clinical relevance of AS1411 as a delivery vehicle was strongly indicated by demonstration of the presence of cell surface nucleolin on the photoreceptors, inner neurons and ganglion cells of human retina.	AGRO 100	22-28	nucleolin	Homo sapiens	123-132
27032748-3	2016	The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates the binding and uptake of AS1411.	AGRO 100	30-36	nucleolin	Homo sapiens	40-49
27032748-3	2016	The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates the binding and uptake of AS1411.	AGRO 100	30-36	nucleolin	Homo sapiens	51-54
27032748-3	2016	The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates the binding and uptake of AS1411.	AGRO 100	183-189	nucleolin	Homo sapiens	40-49
27032748-3	2016	The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates the binding and uptake of AS1411.	AGRO 100	183-189	nucleolin	Homo sapiens	51-54
27032748-11	2016	These findings, besides validating cell-surface-expressed NCL as an antiviral target, open the way for the possible use of AS1411 as a new potent and promisingly safe anti-HIV-1 agent.	AGRO 100	123-129	nucleolin	Homo sapiens	58-61
27039356-2	2016	In the present study, we have developed gemcitabine (GEM)-loaded AS1411 aptamer surface-decorated polyethylene glycol-poly(lactic-co-glycolic acid) nanopolymersome (Apt-GEM-NP) to target nucleolin-overexpressing non-small cell lung cancer (NSCLC; A549).	AGRO 100	65-71	nucleolin	Homo sapiens	187-196
27039356-8	2016	3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay clearly showed the enhanced cell proliferation inhibitory effect of AS1411-conjugated NP on account of the selective delivery of GEM to the nucleolin-overexpressing cancer cells.	AGRO 100	135-141	nucleolin	Homo sapiens	207-216
27039356-9	2016	Our results showed that AS1411 aptamer conjugation on the surface of NP could be a potential treatment strategy for A549 as a nucleolin-overexpressing cell line.	AGRO 100	24-30	nucleolin	Homo sapiens	126-135
26873366-10	2016	In this research, by taking advantage of the supermolecular interactions between amphiphilic graft polyphosphazene and cholesterol which was linked to aptamer AS1411, we prepared a targeted functional polymersome (PEP-DOX HCl-Ap) through a simple method with high loading of water soluble anti-cancer drug doxorubicin hydrochloride.	AGRO 100	159-165	prolyl endopeptidase	Mus musculus	214-217
26840019-5	2016	We conjugated AS1411 aptamer to carboxy terminated poly(ethylene glycol)-block-poly(d, l-lactide) (HOOC-PEG-PDLLA), then prepared AS1411-PEG-PDLLA micelle loading TP (AS-PPT) through solid dispersion technique.	AGRO 100	14-20	tachykinin precursor 1	Homo sapiens	170-173
26840019-6	2016	AS-PPT showed more antitumor activity than TP and equivalent specific binding ability with gemcitabine-resistant human pancreatic cancer cell (MIA PaCa-2) to AS1411 aptamer in vitro.	AGRO 100	158-164	tachykinin precursor 1	Homo sapiens	3-6
26523833-3	2015	AS1411 inhibits tumor cell growth by binding to nucleolin which is aberrantly expressed on the cell membrane of many tumors.	AGRO 100	0-6	nucleolin	Homo sapiens	48-57
26695322-3	2016	The interaction between nucleolin and AS1411 induced surface stress changes, resulting in a differential deflection between sensor and reference cantilevers.	AGRO 100	38-44	nucleolin	Homo sapiens	24-33
26558409-5	2015	Owing to the much stronger specific interaction of AS1411 and nucleolin, the presence of nucleolin could take Cy5.5-AS1411 apart from Fe3O4@PPY and restore the fluorescence of Cy5.5-AS1411.	AGRO 100	51-57	nucleolin	Homo sapiens	62-71
26558409-5	2015	Owing to the much stronger specific interaction of AS1411 and nucleolin, the presence of nucleolin could take Cy5.5-AS1411 apart from Fe3O4@PPY and restore the fluorescence of Cy5.5-AS1411.	AGRO 100	51-57	nucleolin	Homo sapiens	89-98
26558409-7	2015	Compared to nonseparation FRET inhibition, the separation of free Cy5.5-AS1411 from Cy5.5-AS1411-Fe3O4@PPY solution (the first magnetic separation, MS-1) had as high as 25-fold enhancement of the sensitivity, whereas further separation of the nucleolin-inducing far-between Fe3O4@PPY from the FRET inhibition solution (the second magnetic separation, MS-2) could further enhance the sensitivity to 35-fold.	AGRO 100	72-78	nucleolin	Homo sapiens	243-252
26142627-3	2015	Specially, the AS1411 initiates the hybridization of acrydite-modified oligonucleotides to form the hydrogels and the presence of the target protein nucleolin leads the gel to dissolve as a result of reducing the cross-linking density by competitive target-aptamer binding.	AGRO 100	15-21	nucleolin	Homo sapiens	149-158
26507179-2	2015	Here we synthesize the fluorescent gold nanoparticles conjugated with diatrizoic acid and nucleolin-targeted AS1411 aptamer.	AGRO 100	109-115	nucleolin	Mus musculus	90-99
26302208-5	2015	The pendant linear sequence is an aptamer, in this case AS1411, known to specifically bind nucleolin, typically overexpressed on the plasma membranes of tumor cells.	AGRO 100	56-62	nucleolin	Homo sapiens	91-100
27005093-0	2015	Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles: A dual-functional strategy for paclitaxel delivery.	AGRO 100	20-26	nucleolin	Homo sapiens	0-9
25911416-0	2015	Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation.	AGRO 100	42-48	nucleolin	Homo sapiens	73-82
26222682-5	2015	These Raman nanoprobes co-conjugated with AS1411 showed high affinity for tumor cells with overexpressed nucleolin and can be used for selective tumor cell screening and tissue imaging.	AGRO 100	42-48	nucleolin	Homo sapiens	105-114
26262951-4	2015	Here aptamer AS1411, which can recognize and bind overexpressed nucleolin on a cancer cell membrane, was chemically conjugated onto CMCs.	AGRO 100	13-19	nucleolin	Mus musculus	64-73
26045302-1	2015	AS1411 is a quadruplex-forming DNA oligonucleotide that functions as an aptamer to target nucleolin, a protein present on the surface of cancer cells.	AGRO 100	0-6	nucleolin	Mus musculus	90-99
26186684-7	2015	Benefiting from the high brightness of AS1411 enhanced DNA-AgNCs and the specific binding affinity of AS1411 for nucleolin, the AS1411 enhanced AgNCs can stain cancer cells for bioimaging.	AGRO 100	102-108	nucleolin	Homo sapiens	113-122
26186684-7	2015	Benefiting from the high brightness of AS1411 enhanced DNA-AgNCs and the specific binding affinity of AS1411 for nucleolin, the AS1411 enhanced AgNCs can stain cancer cells for bioimaging.	AGRO 100	102-108	nucleolin	Homo sapiens	113-122
25911416-0	2015	Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation.	AGRO 100	42-48	Rac family small GTPase 1	Homo sapiens	97-101
25911416-1	2015	AS1411 is a G-rich quadruplex-forming oligodeoxynucleotide that binds specifically to nucleolin, a protein found on the surface and in the cytoplasm of most malignant cells but absent from the surface/cytoplasm of most normal cells.	AGRO 100	0-6	nucleolin	Homo sapiens	86-95
25911416-3	2015	Previously, we showed that AS1411 is taken up in cancer cells by macropinocytosis (fluid phase endocytosis) and subsequently stimulates further macropinocytosis by a nucleolin-dependent mechanism.	AGRO 100	27-33	nucleolin	Homo sapiens	166-175
25911416-6	2015	In DU145 prostate cancer cells, AS1411 induced activation of EGFR, Akt, p38, and Rac1.	AGRO 100	32-38	epidermal growth factor receptor	Homo sapiens	61-65
25911416-6	2015	In DU145 prostate cancer cells, AS1411 induced activation of EGFR, Akt, p38, and Rac1.	AGRO 100	32-38	AKT serine/threonine kinase 1	Homo sapiens	67-70
25911416-6	2015	In DU145 prostate cancer cells, AS1411 induced activation of EGFR, Akt, p38, and Rac1.	AGRO 100	32-38	mitogen-activated protein kinase 14	Homo sapiens	72-75
25911416-6	2015	In DU145 prostate cancer cells, AS1411 induced activation of EGFR, Akt, p38, and Rac1.	AGRO 100	32-38	Rac family small GTPase 1	Homo sapiens	81-85
25911416-8	2015	On the other hand, activation of EGFR and Rac1 appeared to play a role in AS1411 activity in all cancer cell lines examined (DU145, MDA-MB-468, A549, LNCaP) and their inhibition significantly reduced AS1411-mediated macropinocytosis and AS1411 antiproliferative activity.	AGRO 100	74-80	epidermal growth factor receptor	Homo sapiens	33-37
25911416-8	2015	On the other hand, activation of EGFR and Rac1 appeared to play a role in AS1411 activity in all cancer cell lines examined (DU145, MDA-MB-468, A549, LNCaP) and their inhibition significantly reduced AS1411-mediated macropinocytosis and AS1411 antiproliferative activity.	AGRO 100	74-80	Rac family small GTPase 1	Homo sapiens	42-46
25911416-8	2015	On the other hand, activation of EGFR and Rac1 appeared to play a role in AS1411 activity in all cancer cell lines examined (DU145, MDA-MB-468, A549, LNCaP) and their inhibition significantly reduced AS1411-mediated macropinocytosis and AS1411 antiproliferative activity.	AGRO 100	200-206	epidermal growth factor receptor	Homo sapiens	33-37
25911416-8	2015	On the other hand, activation of EGFR and Rac1 appeared to play a role in AS1411 activity in all cancer cell lines examined (DU145, MDA-MB-468, A549, LNCaP) and their inhibition significantly reduced AS1411-mediated macropinocytosis and AS1411 antiproliferative activity.	AGRO 100	200-206	Rac family small GTPase 1	Homo sapiens	42-46
25911416-8	2015	On the other hand, activation of EGFR and Rac1 appeared to play a role in AS1411 activity in all cancer cell lines examined (DU145, MDA-MB-468, A549, LNCaP) and their inhibition significantly reduced AS1411-mediated macropinocytosis and AS1411 antiproliferative activity.	AGRO 100	200-206	epidermal growth factor receptor	Homo sapiens	33-37
25911416-8	2015	On the other hand, activation of EGFR and Rac1 appeared to play a role in AS1411 activity in all cancer cell lines examined (DU145, MDA-MB-468, A549, LNCaP) and their inhibition significantly reduced AS1411-mediated macropinocytosis and AS1411 antiproliferative activity.	AGRO 100	200-206	Rac family small GTPase 1	Homo sapiens	42-46
25911416-10	2015	Our results are consistent with a model whereby AS1411 binding to nucleolin leads to sustained activation of Rac1 and causes methuosis, a novel type of nonapoptotic cell death characterized by hyperstimulation of macropinocytosis.	AGRO 100	48-54	nucleolin	Homo sapiens	66-75
25911416-10	2015	Our results are consistent with a model whereby AS1411 binding to nucleolin leads to sustained activation of Rac1 and causes methuosis, a novel type of nonapoptotic cell death characterized by hyperstimulation of macropinocytosis.	AGRO 100	48-54	Rac family small GTPase 1	Homo sapiens	109-113
25172439-9	2014	It could be concluded that a facile high-fluorescence-strength QD conjugated with a DNA aptamer, AS1411, which can recognize the extracellular matrix protein nucleolin, can specifically target U87MG human glioblastoma cells.	AGRO 100	97-103	nucleolin	Homo sapiens	158-167
25417796-5	2015	In addition, there is a remarkable affinity interaction between the AS1411 aptamer and the nucleolin protein on the cancer cell surface.	AGRO 100	68-74	nucleolin	Homo sapiens	91-100
25673264-1	2015	AS1411, a 26-base guanine-rich oligonucleotide aptamer, has high affinity to nucleolin, mainly on tumor cell surfaces.	AGRO 100	0-6	nucleolin	Mus musculus	77-86
23679916-0	2013	Nucleolin targeting AS1411 modified protein nanoparticle for antitumor drugs delivery.	AGRO 100	20-26	nucleolin	Homo sapiens	0-9
24242861-0	2014	A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma.	AGRO 100	20-26	nucleolin	Homo sapiens	36-45
24242861-2	2014	AS1411, a DNA aptamer targeting nucleolin (a protein which is overexpressed in many tumor types), was evaluated in patients with metastatic, clear-cell, renal cell carcinoma (RCC) who had failed treatment with >=1 prior tyrosine kinase inhibitor.	AGRO 100	0-6	nucleolin	Homo sapiens	32-41
24373858-1	2014	INTRODUCTION: AS1411 is a 26-base guanine-rich oligonucleotide aptamer shown binding to surface nucleolin, a protein over-expressed in multiple cancer cells, thus AS1411 labeled with a PET isotope can be explored as a potential diagnostic imaging agent.	AGRO 100	14-20	nucleolin	Homo sapiens	96-105
24373858-1	2014	INTRODUCTION: AS1411 is a 26-base guanine-rich oligonucleotide aptamer shown binding to surface nucleolin, a protein over-expressed in multiple cancer cells, thus AS1411 labeled with a PET isotope can be explored as a potential diagnostic imaging agent.	AGRO 100	163-169	nucleolin	Homo sapiens	96-105
24156476-2	2014	In this study, AS1411 (AP), a DNA aptamer specifically binding to nucleolin that is overexpressed on the plasma membrane of breast cancer (BC) cells, was exploited as the targeting ligand of a nanoparticle-based drug delivery system.	AGRO 100	15-21	nucleolin	Homo sapiens	66-75
24274270-3	2014	Using HeLa cells over expressing nucleolin as representative cancer cells, the formed NAANPs can target to the cell surface via the specific AS1411-nucleolin interaction, which can discriminate the cancer cells from normal ones (e.g. HEK293) unambiguously.	AGRO 100	141-147	nucleolin	Homo sapiens	33-42
24274270-3	2014	Using HeLa cells over expressing nucleolin as representative cancer cells, the formed NAANPs can target to the cell surface via the specific AS1411-nucleolin interaction, which can discriminate the cancer cells from normal ones (e.g. HEK293) unambiguously.	AGRO 100	141-147	nucleolin	Homo sapiens	148-157
24159374-5	2013	Liposomes were prepared containing doxorubicin as a payload, and functionalized with AS1411, a DNA aptamer with strong binding affinity for nucleolin.	AGRO 100	85-91	nucleolin	Homo sapiens	140-149
24159374-8	2013	This study suggests that AS1411 aptamer-functionalized liposomes can recognize nucleolin overexpressed on MCF-7 cell surface, and therefore enable drug delivery with high specificity and selectivity.	AGRO 100	25-31	nucleolin	Homo sapiens	79-88
25142997-10	2014	CONCLUSION: AS1411 may induce the apoptosis of A549/T cells through inhibiting the AKT-ERK pathways.	AGRO 100	12-18	AKT serine/threonine kinase 1	Homo sapiens	83-86
25142997-10	2014	CONCLUSION: AS1411 may induce the apoptosis of A549/T cells through inhibiting the AKT-ERK pathways.	AGRO 100	12-18	mitogen-activated protein kinase 1	Homo sapiens	87-90
24486214-0	2014	Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas.	AGRO 100	48-54	nucleolin	Mus musculus	0-9
24486214-4	2014	AS1411, an aptamer showing specific binding to nucleolin, was conjugated to PEGylated cationic liposome as the targeting probe ASLP (AS1411-PEG-liposome).	AGRO 100	0-6	nucleolin	Mus musculus	47-56
24486214-10	2014	These results suggested that the new nucleolin-targeted siRNA delivery system by AS1411 may have the potential for the treatment of melanoma.	AGRO 100	81-87	nucleolin	Mus musculus	37-46
23679916-2	2013	To improve the antitumor efficacy, we developed a nucleolin targeted protein nanoparticle (NTPN) delivery system in which human serum albumin (HSA) was used as drug carrier and a DNA aptamer named AS1411, which had high affinity to nucleolin, was used as a bullet.	AGRO 100	197-203	nucleolin	Homo sapiens	50-59
23679916-2	2013	To improve the antitumor efficacy, we developed a nucleolin targeted protein nanoparticle (NTPN) delivery system in which human serum albumin (HSA) was used as drug carrier and a DNA aptamer named AS1411, which had high affinity to nucleolin, was used as a bullet.	AGRO 100	197-203	nucleolin	Homo sapiens	232-241
23845492-3	2013	Meanwhile, a nano-bio-probe was constructed by coupling of nucleolin aptamer AS1411 (Apt2) to CdTe quantum dots (QDs) which were homogeneously coated on the surfaces of monodispersed silica nanoparticles (SiO2 NPs).	AGRO 100	77-83	nucleolin	Homo sapiens	59-68
23845492-3	2013	Meanwhile, a nano-bio-probe was constructed by coupling of nucleolin aptamer AS1411 (Apt2) to CdTe quantum dots (QDs) which were homogeneously coated on the surfaces of monodispersed silica nanoparticles (SiO2 NPs).	AGRO 100	77-83	lysophospholipase 2	Homo sapiens	85-89
23845492-4	2013	The nano-bio-probe displayed similar optical and electrochemical performances to free CdTe QDs, and remained high affinity to nucleolin overexpressed cells through the interaction between AS1411 and nucleolin protein.	AGRO 100	188-194	nucleolin	Homo sapiens	126-135
23845492-4	2013	The nano-bio-probe displayed similar optical and electrochemical performances to free CdTe QDs, and remained high affinity to nucleolin overexpressed cells through the interaction between AS1411 and nucleolin protein.	AGRO 100	188-194	nucleolin	Homo sapiens	199-208
22973579-14	2004	AS1411 is a G-rich DNA aptamer that exhibits high binding affinity to nucleolin, a highly expressed protein in the plasma membrane of cancer cells including the C6 glioma cells (6, 7).	AGRO 100	0-6	nucleolin	Homo sapiens	70-79
23421130-4	2012	The as-prepared QDs were then conjugated with the AS1411 aptamer recognizing the nucleolin overexpressed on cancer cell surface.	AGRO 100	50-56	nucleolin	Homo sapiens	81-90
22840709-2	2012	In the presence of potassium ion, AS1411 folded to G-quadruplex structure, binded fluorescent ligand (PPIX) with fluorescent enhancement, and targeted the nucleolin overexpressed by cancer cells.	AGRO 100	34-40	nucleolin	Homo sapiens	155-164
22703281-4	2012	We investigated the ability of the nucleolin aptamer (AS1411) to internalize into multiple cancer cell types and observed that it internalizes into a wide variety of cancer cells and migrates to the nucleus.	AGRO 100	54-60	nucleolin	Homo sapiens	35-44
22973579-0	2004	Indotricarbocyanine-loaded AS1411 DNA aptamer- and TGN peptide-modified poly(ethylene glycol)-poly(epsilon-caprolactone) nanoparticles Indotricarbocyanine (DiR)-loaded AS1411 DNA aptamer- and TGN peptide-modified poly(ethylene glycol)-poly(epsilon-caprolactone) (PEG-PCL) nanoparticles, abbreviated as DiR-AsTNP, is a cascade delivery system synthesized by Gao et al.	AGRO 100	27-33	arginine vasopressin receptor 2	Homo sapiens	156-159
22973579-0	2004	Indotricarbocyanine-loaded AS1411 DNA aptamer- and TGN peptide-modified poly(ethylene glycol)-poly(epsilon-caprolactone) nanoparticles Indotricarbocyanine (DiR)-loaded AS1411 DNA aptamer- and TGN peptide-modified poly(ethylene glycol)-poly(epsilon-caprolactone) (PEG-PCL) nanoparticles, abbreviated as DiR-AsTNP, is a cascade delivery system synthesized by Gao et al.	AGRO 100	27-33	arginine vasopressin receptor 2	Homo sapiens	302-305
21256585-2	2011	By taking advantages of AS1411 high binding affinity and specificity to the overexpressed nucleolin on the cancer cell surface, our developed electrochemical aptasensor can distinguish cancer cells and normal ones and detect as low as one thousand cells.	AGRO 100	24-30	nucleolin	Homo sapiens	90-99
22265525-2	2012	AS1411 (a G-quadruplex that can bind nucleolin overexpressed in cancer cells) is used as the main model template to prove the synthesis protocol and its potential application.	AGRO 100	0-6	nucleolin	Homo sapiens	37-46
22265525-4	2012	It is found that after formation of the silver nanocluster, AS1411 still keeps its structure and is able to bind with nucleolin in cancer cell.	AGRO 100	60-66	nucleolin	Homo sapiens	118-127
22693611-7	2012	Functional interaction between COUP-TFII and nucleolin was indicated by studies showing that siRNA knockdown of nucleolin and an oligonucleotide aptamer that targets nucleolin, AS1411, inhibited endogenous COUP-TFII-stimulated RARB2 expression in MCF-7 and T47D cells.	AGRO 100	177-183	nuclear receptor subfamily 2 group F member 2	Homo sapiens	31-40
22693611-7	2012	Functional interaction between COUP-TFII and nucleolin was indicated by studies showing that siRNA knockdown of nucleolin and an oligonucleotide aptamer that targets nucleolin, AS1411, inhibited endogenous COUP-TFII-stimulated RARB2 expression in MCF-7 and T47D cells.	AGRO 100	177-183	nucleolin	Homo sapiens	45-54
22693611-7	2012	Functional interaction between COUP-TFII and nucleolin was indicated by studies showing that siRNA knockdown of nucleolin and an oligonucleotide aptamer that targets nucleolin, AS1411, inhibited endogenous COUP-TFII-stimulated RARB2 expression in MCF-7 and T47D cells.	AGRO 100	177-183	nucleolin	Homo sapiens	112-121
22693611-7	2012	Functional interaction between COUP-TFII and nucleolin was indicated by studies showing that siRNA knockdown of nucleolin and an oligonucleotide aptamer that targets nucleolin, AS1411, inhibited endogenous COUP-TFII-stimulated RARB2 expression in MCF-7 and T47D cells.	AGRO 100	177-183	nucleolin	Homo sapiens	112-121
22693611-7	2012	Functional interaction between COUP-TFII and nucleolin was indicated by studies showing that siRNA knockdown of nucleolin and an oligonucleotide aptamer that targets nucleolin, AS1411, inhibited endogenous COUP-TFII-stimulated RARB2 expression in MCF-7 and T47D cells.	AGRO 100	177-183	nuclear receptor subfamily 2 group F member 2	Homo sapiens	206-215
21788069-2	2011	We developed a nanoparticulate drug delivery system decorated with AS1411 (Ap), a DNA aptamer specifically binding to nucleolin which was highly expressed in the plasma membrane of both cancer cells and endothelial cells in angiogenic blood vessels, as the targeting ligand to facilitate anti-glioma delivery of paclitaxel (PTX).	AGRO 100	67-73	nucleolin	Rattus norvegicus	118-127
21989776-4	2011	Furthermore, fluorescence imaging using CdTe/CdSe QDs conjugated with the AS1411 aptamer (targeting nucleolin) probe in cancer cells was reported, and the CdTe/CdSe QDs were also successfully applied for the fluorescence imaging of living animals.	AGRO 100	74-80	nucleolin	Homo sapiens	100-109
21071077-4	2011	Fluorescence, radioisotope, and magnetic resonance analysis demonstrated that the SMART cancer probe simultaneously targeting the nucleolin, integrin alpha(v)beta(3) and Tnc proteins had dramatically enhanced specificity and signal intensity when used to target cancers from C6, NPA, DU145, HeLa and A549 cells when compared with single cancer probes conjugated with AS1411, RGD or TTA1 targeting a single cancer biomarker.	AGRO 100	367-373	nucleolin	Homo sapiens	130-139
21071077-4	2011	Fluorescence, radioisotope, and magnetic resonance analysis demonstrated that the SMART cancer probe simultaneously targeting the nucleolin, integrin alpha(v)beta(3) and Tnc proteins had dramatically enhanced specificity and signal intensity when used to target cancers from C6, NPA, DU145, HeLa and A549 cells when compared with single cancer probes conjugated with AS1411, RGD or TTA1 targeting a single cancer biomarker.	AGRO 100	367-373	integrin subunit alpha V	Homo sapiens	141-165
21071077-4	2011	Fluorescence, radioisotope, and magnetic resonance analysis demonstrated that the SMART cancer probe simultaneously targeting the nucleolin, integrin alpha(v)beta(3) and Tnc proteins had dramatically enhanced specificity and signal intensity when used to target cancers from C6, NPA, DU145, HeLa and A549 cells when compared with single cancer probes conjugated with AS1411, RGD or TTA1 targeting a single cancer biomarker.	AGRO 100	367-373	tenascin C	Homo sapiens	170-173
20460757-6	2010	Fluorescein isothiocyanate (FITC)-AS1411 was more rapidly incorporated into MKN-45 and AGS than into MKN-1 cells, based on varying amounts of cell surface nucleolin.	AGRO 100	34-40	nucleolin	Homo sapiens	155-164
20140822-0	2010	AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia.	AGRO 100	0-7	nucleolin	Homo sapiens	60-69
20140822-3	2010	Instead, AS-1411 appears to bind to nucleolin specifically, and is subsequently internalized into the tumor cell.	AGRO 100	9-16	nucleolin	Homo sapiens	36-45
20140822-5	2010	Because of the multifunctional nature of nucleolin, it is probable that many secondary targets are affected following treatment with AS-1411.	AGRO 100	133-140	nucleolin	Homo sapiens	41-50
20861190-0	2010	A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism.	AGRO 100	39-45	nucleolin	Homo sapiens	106-115
20861190-4	2010	Previously, we proposed a model where cell surface nucleolin serves as the receptor for AS1411, leading to selective uptake in cancer cells.	AGRO 100	88-94	nucleolin	Homo sapiens	51-60
20861190-11	2010	Our results are inconsistent with the previous mechanistic model but confirm that nucleolin plays a role in mediating AS1411 effects.	AGRO 100	118-124	nucleolin	Homo sapiens	82-91
20571027-11	2010	This suggests that the degradation of bcl-2 mRNA induced by AS1411 results from both interference with nucleolin protection of bcl-2 mRNA and recruitment of the exosome by AUF1.	AGRO 100	60-66	BCL2 apoptosis regulator	Homo sapiens	38-43
20571027-11	2010	This suggests that the degradation of bcl-2 mRNA induced by AS1411 results from both interference with nucleolin protection of bcl-2 mRNA and recruitment of the exosome by AUF1.	AGRO 100	60-66	nucleolin	Homo sapiens	103-112
20571027-11	2010	This suggests that the degradation of bcl-2 mRNA induced by AS1411 results from both interference with nucleolin protection of bcl-2 mRNA and recruitment of the exosome by AUF1.	AGRO 100	60-66	BCL2 apoptosis regulator	Homo sapiens	127-132
20571027-11	2010	This suggests that the degradation of bcl-2 mRNA induced by AS1411 results from both interference with nucleolin protection of bcl-2 mRNA and recruitment of the exosome by AUF1.	AGRO 100	60-66	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	172-176
20460757-7	2010	We think that AS1411 first binds to nucleolin on the cell surface and that the binding complex is then incorporated into the cells.	AGRO 100	14-20	nucleolin	Homo sapiens	36-45
18059017-6	2008	Furthermore, a novel G-rich oligonucleotide, AS1411 that binds the post-transcriptional regulator nucleolin induced BMP2 exclusively in infected cells.	AGRO 100	45-51	nucleolin	Homo sapiens	98-107
20008986-3	2010	METHODS: A cobalt-ferrite nanoparticle surrounded by fluorescent rhodamine (designated MF) within a silica shell matrix was synthesized with the AS1411 aptamer (MF-AS1411) that targets nucleolin (a cellular membrane protein highly expressed in cancer) using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide (EDC).	AGRO 100	145-151	nucleolin	Mus musculus	185-194
19657047-0	2009	Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells.	AGRO 100	67-73	nucleolin	Homo sapiens	16-25
19657047-2	2009	AS1411 binds to nucleolin, a protein that is overexpressed in the cytoplasm and on the plasma membrane of some tumor cells compared with normal cells.	AGRO 100	0-6	nucleolin	Homo sapiens	16-25
19657047-3	2009	Studies were performed to determine whether cell surface nucleolin is a receptor for AS1411 in the acute myeloid leukemia cell line MV4-11.	AGRO 100	85-91	nucleolin	Homo sapiens	57-66
19657047-7	2009	Anti-nucleolin antibody inhibited binding of fluorescein isothiocyanate (FITC)-AS1411 to plasma membrane nucleolin 56 +/- 10% SE (P < 0.01) compared with cells incubated with FITC-AS1411 only.	AGRO 100	79-85	nucleolin	Homo sapiens	5-14
19657047-7	2009	Anti-nucleolin antibody inhibited binding of fluorescein isothiocyanate (FITC)-AS1411 to plasma membrane nucleolin 56 +/- 10% SE (P < 0.01) compared with cells incubated with FITC-AS1411 only.	AGRO 100	79-85	nucleolin	Homo sapiens	105-114
19657047-10	2009	Partial knockdown of plasma membrane and cytosolic nucleolin in MCF-7 cells resulted in a 3-fold decrease in AS1411 uptake.	AGRO 100	109-115	nucleolin	Homo sapiens	51-60
18059017-6	2008	Furthermore, a novel G-rich oligonucleotide, AS1411 that binds the post-transcriptional regulator nucleolin induced BMP2 exclusively in infected cells.	AGRO 100	45-51	bone morphogenetic protein 2	Homo sapiens	116-120
18381443-2	2008	Furthermore, we examined the efficacy of the aptamer AS1411 in targeting nucleolin and inducing bcl-2 mRNA instability and cytotoxicity in these cells.	AGRO 100	53-59	nucleolin	Homo sapiens	73-82
18381443-2	2008	Furthermore, we examined the efficacy of the aptamer AS1411 in targeting nucleolin and inducing bcl-2 mRNA instability and cytotoxicity in these cells.	AGRO 100	53-59	BCL2 apoptosis regulator	Homo sapiens	96-101
18381443-4	2008	This selectivity of AS1411 was related to a greater uptake of AS1411 into the cytoplasm of MCF-7 cells compared with MCF-10A cells and to a 4-fold higher level of cytoplasmic nucleolin in MCF-7 cells.	AGRO 100	20-26	nucleolin	Homo sapiens	175-184
18381443-6	2008	Similarly, AS1411 (10 micromol/L) decreased the half-life of bcl-2 mRNA in MCF-7 and MDA-MB-231 cells to 1.0 and 1.2 hours, respectively.	AGRO 100	11-17	BCL2 apoptosis regulator	Homo sapiens	61-66
18381443-8	2008	AS1411 also inhibited the binding of nucleolin to the instability element AU-rich element 1 of bcl-2 mRNA in a cell-free system and in MCF-7 cells.	AGRO 100	0-6	nucleolin	Homo sapiens	37-46
18381443-8	2008	AS1411 also inhibited the binding of nucleolin to the instability element AU-rich element 1 of bcl-2 mRNA in a cell-free system and in MCF-7 cells.	AGRO 100	0-6	BCL2 apoptosis regulator	Homo sapiens	95-100
18381443-9	2008	Together, the results suggest that AS1411 acts as a molecular decoy by competing with bcl-2 mRNA for binding to cytoplasmic nucleolin in these breast cancer cell lines.	AGRO 100	35-41	BCL2 apoptosis regulator	Homo sapiens	86-91
18381443-9	2008	Together, the results suggest that AS1411 acts as a molecular decoy by competing with bcl-2 mRNA for binding to cytoplasmic nucleolin in these breast cancer cell lines.	AGRO 100	35-41	nucleolin	Homo sapiens	124-133
18381443-10	2008	This interferes with the stabilization of bcl-2 mRNA by nucleolin and may be one mechanism by which AS1411 induces tumor cell death.	AGRO 100	100-106	BCL2 apoptosis regulator	Homo sapiens	42-47
18381443-10	2008	This interferes with the stabilization of bcl-2 mRNA by nucleolin and may be one mechanism by which AS1411 induces tumor cell death.	AGRO 100	100-106	nucleolin	Homo sapiens	56-65
17974993-0	2007	AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin.	AGRO 100	0-6	protein arginine methyltransferase 5	Homo sapiens	55-91
17974993-0	2007	AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin.	AGRO 100	0-6	nucleolin	Homo sapiens	96-105
17974993-1	2007	AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin.	AGRO 100	0-6	nucleolin	Homo sapiens	68-77
17974993-3	2007	We have proposed that AS1411 inhibits cancer cell proliferation by affecting the activities of certain nucleolin-containing complexes.	AGRO 100	22-28	nucleolin	Homo sapiens	103-112
17974993-4	2007	Here, we report that protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes the formation of symmetrical dimethylarginine (sDMA), is a nucleolin-associated protein whose localization and activity are altered by AS1411.	AGRO 100	227-233	protein arginine methyltransferase 5	Homo sapiens	21-57
17974993-4	2007	Here, we report that protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes the formation of symmetrical dimethylarginine (sDMA), is a nucleolin-associated protein whose localization and activity are altered by AS1411.	AGRO 100	227-233	protein arginine methyltransferase 5	Homo sapiens	59-64
17974993-4	2007	Here, we report that protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes the formation of symmetrical dimethylarginine (sDMA), is a nucleolin-associated protein whose localization and activity are altered by AS1411.	AGRO 100	227-233	nucleolin	Homo sapiens	151-160
17974993-5	2007	Levels of PRMT5 were found to be decreased in the nucleus of AS1411-treated DU145 human prostate cancer cells, but increased in the cytoplasm.	AGRO 100	61-67	protein arginine methyltransferase 5	Homo sapiens	10-15
17974993-7	2007	Treatment with AS1411 altered levels of PRMT5 activity (assessed by sDMA levels) in accord with changes in its localization.	AGRO 100	15-21	protein arginine methyltransferase 5	Homo sapiens	40-45
17974993-8	2007	In addition, our data indicate that nucleolin itself is a substrate for PRMT5 and that distribution of sDMA-modified nucleolin is altered by AS1411.	AGRO 100	141-147	nucleolin	Homo sapiens	117-126
17974993-9	2007	Because histone arginine methylation by PRMT5 causes transcriptional repression, we also examined expression of selected PRMT5 target genes in AS1411-treated cells.	AGRO 100	143-149	protein arginine methyltransferase 5	Homo sapiens	121-126
17974993-11	2007	We conclude that nucleolin is a novel binding partner and substrate for PRMT5, and that AS1411 causes relocalization of the nucleolin-PRMT5 complex from the nucleus to the cytoplasm.	AGRO 100	88-94	nucleolin	Homo sapiens	17-26
17974993-11	2007	We conclude that nucleolin is a novel binding partner and substrate for PRMT5, and that AS1411 causes relocalization of the nucleolin-PRMT5 complex from the nucleus to the cytoplasm.	AGRO 100	88-94	protein arginine methyltransferase 5	Homo sapiens	72-77
17974993-11	2007	We conclude that nucleolin is a novel binding partner and substrate for PRMT5, and that AS1411 causes relocalization of the nucleolin-PRMT5 complex from the nucleus to the cytoplasm.	AGRO 100	88-94	nucleolin	Homo sapiens	124-133
17974993-11	2007	We conclude that nucleolin is a novel binding partner and substrate for PRMT5, and that AS1411 causes relocalization of the nucleolin-PRMT5 complex from the nucleus to the cytoplasm.	AGRO 100	88-94	protein arginine methyltransferase 5	Homo sapiens	134-139
17974993-12	2007	Consequently, the nuclear activity of PRMT5 is decreased, leading to derepression of some PRMT5 target genes, which may contribute to the biological effects of AS1411.	AGRO 100	160-166	protein arginine methyltransferase 5	Homo sapiens	38-43
17974993-12	2007	Consequently, the nuclear activity of PRMT5 is decreased, leading to derepression of some PRMT5 target genes, which may contribute to the biological effects of AS1411.	AGRO 100	160-166	protein arginine methyltransferase 5	Homo sapiens	90-95
34517616-4	2021	In this work, target exosomes were first captured by CD63 aptamers modified on magnetic beads (MBs) and then combined with AS1411 aptamer, which shows high binding affinity to nucleolin when forming stable G-quadruplex structure.	AGRO 100	123-129	CD63 molecule	Homo sapiens	53-57
16891465-0	2006	AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.	AGRO 100	0-7	nuclear factor kappa B subunit 1	Homo sapiens	31-52
16891465-0	2006	AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.	AGRO 100	0-7	nuclear factor kappa B subunit 1	Homo sapiens	54-63
16891465-0	2006	AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.	AGRO 100	0-7	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	91-120
16891465-0	2006	AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.	AGRO 100	0-7	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	122-126
16891465-0	2006	AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.	AGRO 100	0-7	nucleolin	Homo sapiens	132-141
16891465-5	2006	Here, we report that AGRO100 also associates with nuclear factor-kappaB (NF-kappaB) essential modulator (NEMO), which is a regulatory subunit of the inhibitor of kappaB (IkappaB) kinase (IKK) complex, and also called IKKgamma.	AGRO 100	21-28	nuclear factor kappa B subunit 1	Homo sapiens	50-71
16891465-5	2006	Here, we report that AGRO100 also associates with nuclear factor-kappaB (NF-kappaB) essential modulator (NEMO), which is a regulatory subunit of the inhibitor of kappaB (IkappaB) kinase (IKK) complex, and also called IKKgamma.	AGRO 100	21-28	nuclear factor kappa B subunit 1	Homo sapiens	73-82
16891465-5	2006	Here, we report that AGRO100 also associates with nuclear factor-kappaB (NF-kappaB) essential modulator (NEMO), which is a regulatory subunit of the inhibitor of kappaB (IkappaB) kinase (IKK) complex, and also called IKKgamma.	AGRO 100	21-28	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	105-109
16891465-5	2006	Here, we report that AGRO100 also associates with nuclear factor-kappaB (NF-kappaB) essential modulator (NEMO), which is a regulatory subunit of the inhibitor of kappaB (IkappaB) kinase (IKK) complex, and also called IKKgamma.	AGRO 100	21-28	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	187-190
16891465-5	2006	Here, we report that AGRO100 also associates with nuclear factor-kappaB (NF-kappaB) essential modulator (NEMO), which is a regulatory subunit of the inhibitor of kappaB (IkappaB) kinase (IKK) complex, and also called IKKgamma.	AGRO 100	21-28	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	217-225
16891465-7	2006	We found that treatment of cancer cells with AGRO100 inhibits IKK activity and reduces phosphorylation of IkappaBalpha in response to tumor necrosis factor-alpha stimulation.	AGRO 100	45-52	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	62-65
16891465-7	2006	We found that treatment of cancer cells with AGRO100 inhibits IKK activity and reduces phosphorylation of IkappaBalpha in response to tumor necrosis factor-alpha stimulation.	AGRO 100	45-52	NFKB inhibitor alpha	Homo sapiens	106-118
16891465-7	2006	We found that treatment of cancer cells with AGRO100 inhibits IKK activity and reduces phosphorylation of IkappaBalpha in response to tumor necrosis factor-alpha stimulation.	AGRO 100	45-52	tumor necrosis factor	Homo sapiens	134-161
16891465-8	2006	Using a reporter gene assay, we showed that AGRO100 blocks both tumor necrosis factor-alpha-induced and constitutive NF-kappaB activity in human cancer cell lines derived from cervical, prostate, breast, and lung carcinomas.	AGRO 100	44-51	tumor necrosis factor	Homo sapiens	64-91
16891465-8	2006	Using a reporter gene assay, we showed that AGRO100 blocks both tumor necrosis factor-alpha-induced and constitutive NF-kappaB activity in human cancer cell lines derived from cervical, prostate, breast, and lung carcinomas.	AGRO 100	44-51	nuclear factor kappa B subunit 1	Homo sapiens	117-126
16891465-10	2006	Our studies suggest that abrogation of NF-kappaB activity may contribute to the anticancer effects of AGRO100 and that nucleolin may play a previously unknown role in regulating the NF-kappaB pathway.	AGRO 100	102-109	nuclear factor kappa B subunit 1	Homo sapiens	39-48
26368850-7	2015	AS1411 is a previously described G-quartet oligonucleotide that has been shown to bind nucleolin.	AGRO 100	0-6	nucleolin	Homo sapiens	87-96
34871712-4	2022	Subsequently, the attachment of AS1411 aptamer via covalent bond led to the formation of the final product beta-CD-(PCL-PAEMA)21/AS1411/CPT.	AGRO 100	32-38	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	107-114
34871712-4	2022	Subsequently, the attachment of AS1411 aptamer via covalent bond led to the formation of the final product beta-CD-(PCL-PAEMA)21/AS1411/CPT.	AGRO 100	129-135	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	107-114
34871712-8	2022	The in vivo experiments revealed the fact that beta-CD-(PCL-PAEMA)21/AS1411/CPT micelles showed high tumor inhibitory potential in comparison with free CPT.	AGRO 100	69-75	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	47-54
34884955-0	2021	AS1411 Nucleolin-Specific Binding Aptamers Reduce Pathological Angiogenesis through Inhibition of Nucleolin Phosphorylation.	AGRO 100	0-6	nucleolin	Rattus norvegicus	7-16
34884955-0	2021	AS1411 Nucleolin-Specific Binding Aptamers Reduce Pathological Angiogenesis through Inhibition of Nucleolin Phosphorylation.	AGRO 100	0-6	nucleolin	Rattus norvegicus	98-107
34884955-3	2021	The aim of the present study is to test the effect of the AS1411, an antiangiogenic nucleolin-binding aptamer, using in vivo, ex vivo and in vitro models of angiogenesis and propose a mechanistic insight.	AGRO 100	58-64	nucleolin	Rattus norvegicus	84-93
34884955-5	2021	Importantly, phosphorylated NCL protein was significantly abolished in HUVEC in the presence of AS1411 without affecting NFkappaB phosphorylation and -21 and 221-angiomiRs, suggesting that the antiangiogenic properties of this molecule are partially mediated by a down regulation in NCL phosphorylation.	AGRO 100	96-102	nucleolin	Rattus norvegicus	28-31
34884955-5	2021	Importantly, phosphorylated NCL protein was significantly abolished in HUVEC in the presence of AS1411 without affecting NFkappaB phosphorylation and -21 and 221-angiomiRs, suggesting that the antiangiogenic properties of this molecule are partially mediated by a down regulation in NCL phosphorylation.	AGRO 100	96-102	nucleolin	Rattus norvegicus	283-286
34517616-4	2021	In this work, target exosomes were first captured by CD63 aptamers modified on magnetic beads (MBs) and then combined with AS1411 aptamer, which shows high binding affinity to nucleolin when forming stable G-quadruplex structure.	AGRO 100	123-129	nucleolin	Homo sapiens	176-185
34517616-5	2021	Then the free myc monomer can spontaneously assemble into higher order G-wire superstructures on the allosteric AS1411, and resulting enhanced fluorescence signal, which can realize sensitive and specific analysis of the target exosomes.	AGRO 100	112-118	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-17
34586789-4	2021	Our results demonstrate that the cellular uptake and the tumor-specific accumulation of ZIPP-Apt:DOX/siHSPs were significantly increased due to the AS1411-nucleolin affinity and further confirmed that the simultaneous depletion of HSP70 and HSP90 sensitized magnetic hyperthermia and chemotherapy-induced cell death both in vitro and in vivo.	AGRO 100	148-154	heat shock protein family A (Hsp70) member 4	Homo sapiens	231-236
34884745-3	2021	The chimera was composed of the AS1411 anti-nucleolin aptamer for cancer cell targeting and the ATP aptamer for loading and triggering the release of doxorubicin in cells.	AGRO 100	32-38	nucleolin	Homo sapiens	44-53
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	nucleolin	Homo sapiens	17-26
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	T-box transcription factor 3	Homo sapiens	126-130
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	nucleolin	Homo sapiens	135-144
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	T-box transcription factor 3	Homo sapiens	209-213
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	nucleolin	Homo sapiens	214-223
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	249-255
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	257-264
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	270-276
34873487-7	2021	Importantly, the nucleolin targeting aptamer, AS1411, exhibits selective anti-cancer activity in these cells and mislocalizes TBX3 and nucleolin to the cytoplasm which correlates with the re-expression of the TBX3/nucleolin target tumor suppressors CDKN1A (p21CIP1) and CDKN2A (p14ARF).	AGRO 100	46-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	278-284
34873487-8	2021	Our findings provide the first evidence that TBX3 requires nucleolin to promote features of sarcomagenesis and that disruption of the oncogenic TBX3-nucleolin interaction by AS1411 may be a novel approach for treating sarcomas.	AGRO 100	174-180	T-box transcription factor 3	Homo sapiens	144-148
34873487-8	2021	Our findings provide the first evidence that TBX3 requires nucleolin to promote features of sarcomagenesis and that disruption of the oncogenic TBX3-nucleolin interaction by AS1411 may be a novel approach for treating sarcomas.	AGRO 100	174-180	nucleolin	Homo sapiens	149-158
34586789-4	2021	Our results demonstrate that the cellular uptake and the tumor-specific accumulation of ZIPP-Apt:DOX/siHSPs were significantly increased due to the AS1411-nucleolin affinity and further confirmed that the simultaneous depletion of HSP70 and HSP90 sensitized magnetic hyperthermia and chemotherapy-induced cell death both in vitro and in vivo.	AGRO 100	148-154	heat shock protein 90 alpha family class A member 1	Homo sapiens	241-246
34542145-6	2021	Intracellular uptake and cytotoxicity experiments confirmed that the nanocarrier DNA-BSA1@DOX had accurate targeting and efficient treatment towards cancer cells due to the high affinity and specificity of AS1411 to nucleolin, which is overexpressed in cancer cells.	AGRO 100	206-212	nucleolin	Homo sapiens	216-225
34382270-12	2021	Furthermore, due to the specific binding between AS1411 and nucleolin up-expressed in cancer cells, the AS-nFAp:Gd/Tb possessed excellent AS1411-targeted fluorescence and MRI imaging properties.	AGRO 100	49-55	nucleolin	Homo sapiens	60-69
34382270-12	2021	Furthermore, due to the specific binding between AS1411 and nucleolin up-expressed in cancer cells, the AS-nFAp:Gd/Tb possessed excellent AS1411-targeted fluorescence and MRI imaging properties.	AGRO 100	138-144	nucleolin	Homo sapiens	60-69
34439193-7	2021	In this work, we used AS1411-AuNPs as a carrier for an acridine orange derivative (C8) or Imiquimod (IQ).	AGRO 100	22-28	homeobox C8	Homo sapiens	82-86
35040831-4	2022	The multi-AS1411 activable probe based on the strand displacement strategy was constructed using multiple copies of the structure-switching AS1411 aptamer (bearing a short poly-A tail) linked together using the poly-T long chain (as a scaffold) which was synthesized by Terminal Deoxynucleotidyl Transferase (TDT)-mediated extension.	AGRO 100	10-16	DNA nucleotidylexotransferase	Homo sapiens	270-307
35040831-4	2022	The multi-AS1411 activable probe based on the strand displacement strategy was constructed using multiple copies of the structure-switching AS1411 aptamer (bearing a short poly-A tail) linked together using the poly-T long chain (as a scaffold) which was synthesized by Terminal Deoxynucleotidyl Transferase (TDT)-mediated extension.	AGRO 100	10-16	DNA nucleotidylexotransferase	Homo sapiens	309-312
35040831-4	2022	The multi-AS1411 activable probe based on the strand displacement strategy was constructed using multiple copies of the structure-switching AS1411 aptamer (bearing a short poly-A tail) linked together using the poly-T long chain (as a scaffold) which was synthesized by Terminal Deoxynucleotidyl Transferase (TDT)-mediated extension.	AGRO 100	140-146	DNA nucleotidylexotransferase	Homo sapiens	270-307
35040831-4	2022	The multi-AS1411 activable probe based on the strand displacement strategy was constructed using multiple copies of the structure-switching AS1411 aptamer (bearing a short poly-A tail) linked together using the poly-T long chain (as a scaffold) which was synthesized by Terminal Deoxynucleotidyl Transferase (TDT)-mediated extension.	AGRO 100	140-146	DNA nucleotidylexotransferase	Homo sapiens	309-312
34723284-4	2021	AS1411 is a synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows a considerably high affinity for NCL, therefore, being capable of inducing growth inhibition in a variety of tumor cells.	AGRO 100	0-6	nucleolin	Homo sapiens	133-136
34723284-5	2021	The high affinity and specificity of AS1411 towards NCL make it a suitable targeting tool, which can be used for the functionalization of therapeutic payloaddelivery nanosystems to selectively target tumor cells.	AGRO 100	37-43	nucleolin	Homo sapiens	52-55
34723284-6	2021	This review explores the advances in NCL-targeting cancer therapy through AS1411-functionalized delivery nanosystems for the selective delivery of a broad spectrum of therapeutic agents.	AGRO 100	74-80	nucleolin	Homo sapiens	37-40
35549176-5	2022	The reactive end-group was then used for the oriented conjugation with AS1411, a DNA aptamer that recognizes nucleolin with high affinity.	AGRO 100	71-77	nucleolin	Homo sapiens	109-118
35364257-6	2022	In addition, the CD/siRNA delivery system mediated by the aptamer AS1411 effectively silenced the expression of Fragile X mental retardation protein (FMRP) and successfully inhibited the migration and invasive propensity of hepatocellular carcinoma (HCC) cells.	AGRO 100	66-72	fragile X messenger ribonucleoprotein 1	Homo sapiens	112-148
35364257-6	2022	In addition, the CD/siRNA delivery system mediated by the aptamer AS1411 effectively silenced the expression of Fragile X mental retardation protein (FMRP) and successfully inhibited the migration and invasive propensity of hepatocellular carcinoma (HCC) cells.	AGRO 100	66-72	fragile X messenger ribonucleoprotein 1	Homo sapiens	150-154
35074639-8	2022	Moreover, the connection of Zidovudine (ZDV) and AS1411 through molecular recognition of nucleobases further optimized the nanoparticles with high affinity to nucleolin which overexpressed on tumor cell membrane, thereby inducing the specific accumulation of nanoparticles in tumor sites.	AGRO 100	49-55	nucleolin	Homo sapiens	159-168
34951442-3	2022	The co-loaded 3A-TDN/DT displayed a targeted uptake by HeLa cancer cells through the high affinity and specificity between AS1411 and nucleolin, a protein overexpressed on many types of cancer cells.	AGRO 100	123-129	nucleolin	Homo sapiens	134-143
35128412-4	2022	One such aptamer is AS1411, a nucleolin targeting, G-quadruplex forming, DNA aptamer.	AGRO 100	20-26	nucleolin	Homo sapiens	30-39