PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34531248-10	2021	mtROS activates Nrf2 in a glycolysis-dependent manner, inducing activation of autophagy, glutaminolysis, mTORC1, and p62/SQSTM1.	mtros	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
28224704-6	2017	Using NP cells established from healthy tissues, our in vitro study revealed that AGEs induced an inflammatory response in NP cells and a degenerative phenotype in a NLRP3-inflammasome-dependent manner related to the receptor for AGEs (RAGE)/NF-kappaB pathway and mitochondrial damage induced by mitochondrial reactive oxygen species (mtROS) generation, mitochondrial permeability transition pore (mPTP) activation and calcium mobilization.	mtros	335-340	NLR family pyrin domain containing 3	Homo sapiens	166-171
28224704-6	2017	Using NP cells established from healthy tissues, our in vitro study revealed that AGEs induced an inflammatory response in NP cells and a degenerative phenotype in a NLRP3-inflammasome-dependent manner related to the receptor for AGEs (RAGE)/NF-kappaB pathway and mitochondrial damage induced by mitochondrial reactive oxygen species (mtROS) generation, mitochondrial permeability transition pore (mPTP) activation and calcium mobilization.	mtros	335-340	long intergenic non-protein coding RNA 914	Homo sapiens	236-240
33763153-10	2021	As a result, the production of mitochondrial reactive oxygen species (mtROS) in the Leptin group was significantly increased (P<0.01), but following treatment with mitoQ, this overproduction of mtROS was significantly decreased to normal levels (P<0.01).	mtros	70-75	leptin	Homo sapiens	84-90
29169180-2	2017	We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen species (mtROS)-mediated activation of the Nlrp3 inflammasome.	mtros	138-143	NLR family, pyrin domain containing 3	Mus musculus	172-177
34559222-8	2021	Here, we demonstrated that CXCL4 production is dependent on the overproduction of mitochondrial reactive oxygen species (mtROS) (p = 0.0079) leading to stabilization of HIF-2alpha (p = 0.029).	mtros	121-126	platelet factor 4	Homo sapiens	27-32
34559222-8	2021	Here, we demonstrated that CXCL4 production is dependent on the overproduction of mitochondrial reactive oxygen species (mtROS) (p = 0.0079) leading to stabilization of HIF-2alpha (p = 0.029).	mtros	121-126	endothelial PAS domain protein 1	Homo sapiens	169-179
34531248-10	2021	mtROS activates Nrf2 in a glycolysis-dependent manner, inducing activation of autophagy, glutaminolysis, mTORC1, and p62/SQSTM1.	mtros	0-5	CREB regulated transcription coactivator 1	Mus musculus	105-111
34531248-10	2021	mtROS activates Nrf2 in a glycolysis-dependent manner, inducing activation of autophagy, glutaminolysis, mTORC1, and p62/SQSTM1.	mtros	0-5	nucleoporin 62	Mus musculus	117-120
34531248-10	2021	mtROS activates Nrf2 in a glycolysis-dependent manner, inducing activation of autophagy, glutaminolysis, mTORC1, and p62/SQSTM1.	mtros	0-5	sequestosome 1	Homo sapiens	121-127
34413791-4	2021	The activation of JNK under hypoxic conditions was dependent on overproduction of mitochondrial reactive oxygen species (mtROS) in cardiomyocytes, and mitochondrial division was identified as the upstream inducer of mtROS overproduction.	mtros	121-126	mitogen-activated protein kinase 8	Homo sapiens	18-21
34413791-4	2021	The activation of JNK under hypoxic conditions was dependent on overproduction of mitochondrial reactive oxygen species (mtROS) in cardiomyocytes, and mitochondrial division was identified as the upstream inducer of mtROS overproduction.	mtros	216-221	mitogen-activated protein kinase 8	Homo sapiens	18-21
35179568-8	2022	Taken together, the present study reveals that mtROS-induced eNOS monomerization is closely associated with the impaired TFEB-autophagic flux axis leading to endothelial dysfunction in diabetic mice.	mtros	47-52	nitric oxide synthase 3, endothelial cell	Mus musculus	61-65
35179568-8	2022	Taken together, the present study reveals that mtROS-induced eNOS monomerization is closely associated with the impaired TFEB-autophagic flux axis leading to endothelial dysfunction in diabetic mice.	mtros	47-52	transcription factor EB	Mus musculus	121-125
32980394-9	2020	Taken together, these findings suggest that L-NRF1 protects mBM-MSCs from arsenite-induced cytotoxicity via suppressing mtROS in addition to facilitating cellular arsenic efflux.	mtros	120-125	nuclear respiratory factor 1	Mus musculus	46-50
35172900-10	2022	Compared with HCs, peripheral CD56dimCD57+ NK cells from SLE patients exhibited altered phenotypes, increased endogenous apoptosis and higher levels of mtROS and ROS.	mtros	152-157	neural cell adhesion molecule 1	Homo sapiens	30-41
35128564-11	2022	In addition, Nox2 inhibitor or mtROS scavenging prevented oxalate-induced cell injury, reversed by an inhibitor of Nox4/1.	mtros	31-36	NADPH oxidase 4	Rattus norvegicus	115-119
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	interleukin 1 alpha	Homo sapiens	26-34
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	NLR family pyrin domain containing 3	Homo sapiens	58-63
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	caspase 1	Homo sapiens	64-73
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	interleukin 1 alpha	Homo sapiens	74-82
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
33774476-8	2021	Moreover, the elevation of NOX4 induces oxidative stress by mitochondrial ROS (mtROS) production, mitochondrial fragmentation, and inhibition of cellular antioxidant process in human astrocytes.	mtros	79-84	NADPH oxidase 4	Homo sapiens	27-31
33307168-9	2021	Moreover, TPA induced opposite phenotypical changes of HCCs, G1 cell cycle arrest, and cell migration, which were prevented by mtROS scavengers and depletion of PKCdelta and HSP60.	mtros	127-132	holocytochrome c synthase	Homo sapiens	55-59
32849646-0	2020	Retraction: The Increase in IL-1beta in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome.	mtros	130-135	interleukin 1 alpha	Homo sapiens	28-36
32849646-0	2020	Retraction: The Increase in IL-1beta in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome.	mtros	130-135	NLR family pyrin domain containing 3	Homo sapiens	163-168
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	mtros	78-83	interleukin 1 beta	Mus musculus	107-115
30829051-8	2019	Upregulation of PGC-1alpha inhibited, whereas PGC-1alpha depletion promoted beta-glycerophosphate-induced mtROS production and calcium deposition.	mtros	106-111	PPARG coactivator 1 alpha	Homo sapiens	46-56
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	mtros	78-83	NLR family, pyrin domain containing 3	Mus musculus	163-206
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	mtros	78-83	NLR family, pyrin domain containing 3	Mus musculus	208-213
30640127-4	2019	Here, we investigated whether HSP22 protects the vascular endothelium from hyperglycemia-induced injury by reducing mtROS production.	mtros	116-121	heat shock protein family B (small) member 8	Homo sapiens	30-35
30538804-8	2018	The beta3-AR/UCP2 axis induces a strong reduction of mitochondrial activity by reducing ATP synthesis and mitochondrial reactive oxygen species (mtROS) content.	mtros	145-150	adrenoceptor beta 3	Homo sapiens	4-12
30500459-6	2019	In further studies, TrxR2 in the mitochondria was alternatively inhibited, which contributed to MtROS accumulation further attenuated PI3K/Akt signaling pathway.	mtros	96-101	thioredoxin reductase 2	Homo sapiens	20-25
30538804-8	2018	The beta3-AR/UCP2 axis induces a strong reduction of mitochondrial activity by reducing ATP synthesis and mitochondrial reactive oxygen species (mtROS) content.	mtros	145-150	uncoupling protein 2	Homo sapiens	13-17
29859240-5	2018	Moreover, H2S exerted its protective effects by lowering the generation of mitochondrial reactive oxygen species (mtROS).	mtros	114-119	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	10-13
29654945-6	2018	FOXO1 inhibition relieved alterations in mitochondrial networks and significantly suppressed the overproduction of mitochondrial reactive oxygen species (mtROS) induced by high glucose in ECs.	mtros	154-159	forkhead box O1	Homo sapiens	0-5