PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31393619-13	2019	Taken together, L-carnitine had a protective effect against CPB-induced MIRI in patients with RVHD, which might be related to its modulation of NF-kappaB and Nrf2 activities.	cpb	60-63	nuclear factor kappa B subunit 1	Homo sapiens	144-153
3718539-3	1986	The inhibitory effect of phosphate ions upon this activity of CPB (but not CPA) suggests that CPA may be responsible for the formation of free phenylalanine seen upon degradation of kinins in plasma or serum.	cpb	62-65	carboxypeptidase A1	Homo sapiens	94-97
831006-16	1977	These data suggest that the stress of CPB results in an outpouring of ADH (or vasopressin) to function as a pressor to produce an increase in peripheral resistance.	cpb	38-41	arginine vasopressin	Homo sapiens	78-89
2897826-8	1988	At the amino acid level, CPE has approximately 20% homology with bovine CPA and 17% homology with bovine CPB.	cpb	105-108	carboxypeptidase E	Bos taurus	25-28
2897826-9	1988	All of the amino acids in CPA and CPB that are thought to be essential for catalytic activity are present in CPE in comparable positions.	cpb	34-37	carboxypeptidase E	Bos taurus	109-112
2897826-10	1988	The homology of CPE with CPA and CPB suggests a common evolutionary origin for the three enzymes.	cpb	33-36	carboxypeptidase E	Bos taurus	16-19
31393619-13	2019	Taken together, L-carnitine had a protective effect against CPB-induced MIRI in patients with RVHD, which might be related to its modulation of NF-kappaB and Nrf2 activities.	cpb	60-63	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
31303066-4	2019	The left- and right-sided CEIC values, serum levels of S100, and serum NSE in the CPB group significantly increased from the beginning to the end of the operation (P < .05).	cpb	82-85	enolase 2	Homo sapiens	71-74
30993020-0	2019	Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.	cpb	111-114	hepatitis A virus cellular receptor 1	Homo sapiens	0-24
30993020-0	2019	Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.	cpb	111-114	hepatitis A virus cellular receptor 1	Homo sapiens	26-31
29997569-8	2018	Results: At the nominal significance level of 0.05, changes in S100beta and in NFH at 1 and 24 h post-CPB were associated with multiple SNPs involving several prospectively determined pathophysiologic pathways, but were not individually significant after multiple comparison adjustments.	cpb	102-105	S100 calcium binding protein B	Homo sapiens	63-71
29733959-7	2018	Among those differentially expressed proteins, several glucose metabolism-related enzymes, including glucose-6-phosphate dehydrogenase (G6PDH), pyruvate dehydrogenase phosphatase (PDP) and fumarate hydratase (FH), were up-regulated, while pyruvate dehydrogenase kinase (PDK) and enolase (ENO) were down-regulated at 24 h poi, suggesting that ISKNV enhanced glucose metabolism in CPB cells in early-stage infection.	cpb	379-382	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	136-141
29997569-8	2018	Results: At the nominal significance level of 0.05, changes in S100beta and in NFH at 1 and 24 h post-CPB were associated with multiple SNPs involving several prospectively determined pathophysiologic pathways, but were not individually significant after multiple comparison adjustments.	cpb	102-105	neurofilament heavy chain	Homo sapiens	79-82
29070816-2	2017	By analyzing longitudinal tumor biopsies from 17 metastatic melanoma patients treated with CPB therapies, we observed point mutations, deletions or loss of heterozygosity (LOH) in beta-2-microglobulin (B2M), an essential component of MHC class I antigen presentation, in 29.4% of patients with progressing disease.	cpb	91-94	beta-2-microglobulin	Homo sapiens	180-200
21273121-15	2011	CONCLUSION: Epicardial application and adjustment of the BACE Device can be performed safely without CPB with effective reduction in MR.	cpb	101-104	beta-secretase 1	Homo sapiens	57-61
29445737-1	2017	Objective: To investigate the effects of TLR3 and TLR9 signaling pathway on brain injury during CPB in rats pretreated with sevoflurane and its possible molecular mechanism.	cpb	96-99	toll-like receptor 3	Rattus norvegicus	41-45
29445737-1	2017	Objective: To investigate the effects of TLR3 and TLR9 signaling pathway on brain injury during CPB in rats pretreated with sevoflurane and its possible molecular mechanism.	cpb	96-99	toll-like receptor 9	Rattus norvegicus	50-54
29445737-9	2017	Compared with CPB group, TLR3 expression increased, and TLR9 and NF-kappaB decreased in Sev group.	cpb	14-17	kallikrein 1-related peptidase C9	Rattus norvegicus	88-91
29445737-11	2017	Conclusion: Sevoflurane intervention can activate TLR3 and TLR9 signaling pathway, upregulate TLR3 expression and downstream TRIF expression, decrease TLR9 expression, and downregulate downstream NF-kappaB expression in CPB rat models, thereby mitigating brain injury induced by inflammatory response during CPB.	cpb	220-223	toll-like receptor 3	Rattus norvegicus	50-54
29445737-11	2017	Conclusion: Sevoflurane intervention can activate TLR3 and TLR9 signaling pathway, upregulate TLR3 expression and downstream TRIF expression, decrease TLR9 expression, and downregulate downstream NF-kappaB expression in CPB rat models, thereby mitigating brain injury induced by inflammatory response during CPB.	cpb	220-223	toll-like receptor 9	Rattus norvegicus	59-63
29445737-11	2017	Conclusion: Sevoflurane intervention can activate TLR3 and TLR9 signaling pathway, upregulate TLR3 expression and downstream TRIF expression, decrease TLR9 expression, and downregulate downstream NF-kappaB expression in CPB rat models, thereby mitigating brain injury induced by inflammatory response during CPB.	cpb	220-223	toll-like receptor 3	Rattus norvegicus	94-98
27438067-11	2016	PB and CPB showed manageable toxicities in KRAS wild-type patients previously managed with standard treatment, including bevacizumab.	cpb	7-10	KRAS proto-oncogene, GTPase	Homo sapiens	43-47
25928274-12	2015	This study shows that FFP, rFVIIa, PCC and inhibition of TFPI correct thrombin generation in the plasma of patients who have undergone surgery requiring CPB.	cpb	153-156	tissue factor pathway inhibitor	Homo sapiens	57-61
25928274-12	2015	This study shows that FFP, rFVIIa, PCC and inhibition of TFPI correct thrombin generation in the plasma of patients who have undergone surgery requiring CPB.	cpb	153-156	coagulation factor II, thrombin	Homo sapiens	70-78
25191323-6	2014	The pattern of individual or simultaneous expression of homing markers (integrin alpha4beta7, CD62L, CXCR3, and CXCR4) suggested that CPB cells homed preferentially to the inflamed gut mucosa.	cpb	134-137	selectin L	Homo sapiens	94-99
25191323-6	2014	The pattern of individual or simultaneous expression of homing markers (integrin alpha4beta7, CD62L, CXCR3, and CXCR4) suggested that CPB cells homed preferentially to the inflamed gut mucosa.	cpb	134-137	C-X-C motif chemokine receptor 3	Homo sapiens	101-106
25191323-6	2014	The pattern of individual or simultaneous expression of homing markers (integrin alpha4beta7, CD62L, CXCR3, and CXCR4) suggested that CPB cells homed preferentially to the inflamed gut mucosa.	cpb	134-137	C-X-C motif chemokine receptor 4	Homo sapiens	112-117
23894368-7	2013	SBP gradient was -4+-3, 14+-9, 10+-4, 0+-11 mmHg in group P and -3+-3, 0+-1, -1+-9, -6+-4 mmHg in group N after induction, during discontinuation of CPB, at the end of surgery and 1 postoperative day respectively.	cpb	149-152	selenium binding protein 1	Homo sapiens	0-3
28223053-1	2017	BACKGROUND: We hypothesized that upregulation of inducible cyclooxygenase 2 (COX-2) contributes to altered coronary arteriolar reactivity early after cardioplegic arrest and cardiopulmonary bypass (CP/CPB) in patients with diabetes mellitus who are undergoing cardiac surgery.	cpb	201-204	prostaglandin-endoperoxide synthase 2	Homo sapiens	59-75
28223053-1	2017	BACKGROUND: We hypothesized that upregulation of inducible cyclooxygenase 2 (COX-2) contributes to altered coronary arteriolar reactivity early after cardioplegic arrest and cardiopulmonary bypass (CP/CPB) in patients with diabetes mellitus who are undergoing cardiac surgery.	cpb	201-204	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-82
28223053-8	2017	After CP/CPB, bradykinin-induced responses in all groups were inhibited by NS398, but this effect was more pronounced in the UDM patients (p < 0.05).	cpb	9-12	kininogen 1	Homo sapiens	14-24
28223053-10	2017	The post-CP/CPB protein levels of the inducible COX-2 were significantly increased compared with pre-CP/CPB values in all groups (p < 0.05), whereas this increase was higher with diabetes than with ND (p < 0.05).	cpb	12-15	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53
28223053-12	2017	CONCLUSIONS: Diabetes and CP/CPB are associated with upregulation in COX-2 expression in human coronary vasculature.	cpb	29-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
25852832-13	2015	Furthermore, using a bent tip needle under a 20  oblique fluoroscopic view, we could safely perform CPB with smaller parameter values.	cpb	100-103	TOR signaling pathway regulator	Homo sapiens	26-29
25277140-8	2014	At higher concentrations, CPB was a partial agonist (EC50 = 14.1 muM; I/Imax = 0.013).	cpb	26-29	latexin	Homo sapiens	65-68
24842200-6	2014	During CPB, COP was reduced by 22% in the HES-group [(16.7 +- 3.9) vs (21.5 +- 2.2) mmHg, P < 0.05] while it was reduced by more than 50% of the pre-CPB value [10.7 +- 2.0 vs (22.7 +- 1.9) mmHg, P < 0.05] in the crystalloid group (P < 0.05 HES-group vs. crystalloid group).	cpb	7-10	caspase recruitment domain family member 16	Homo sapiens	12-15
24403353-10	2014	The TNF-alpha levels may be monitored to identify cyanotic patients at an increased risk of exhibiting augmented IR to CPB.	cpb	119-122	tumor necrosis factor	Homo sapiens	4-13
21921028-10	2011	These results suggest that CPO cleaves acidic amino acids from dietary proteins and peptides, thus complementing the actions of well known digestive carboxypeptidases CPA and CPB.	cpb	175-178	carboxypeptidase O	Homo sapiens	27-30
21156064-2	2010	Huntingtin expressed in immortalized neurons is cleaved near the N-terminus to form N-terminal polypeptides known as cleavage products A and B (cpA and cpB).	cpb	152-155	huntingtin	Mus musculus	0-10
21506142-5	2011	We report two patients with HIT who underwent successful CPB with heparin anticoagulation following plasma exchange (PE) to reduce heparin/PF4 antibody titers.	cpb	57-60	platelet factor 4	Homo sapiens	139-142
21156064-5	2010	RESULTS: Delivery of htt cDNA into the mouse striatum using adeno-associated virus or into primary cortical neurons using lentivirus generated cpA and cpB, indicating that neurons in brain and in vitro can form these fragments.	cpb	151-154	huntingtin	Mus musculus	21-24
21156064-11	2010	CONCLUSION: We show that cpA and cpB are produced from a larger huntingtin fragment in vivo in mouse brain and in primary neuron cultures.	cpb	33-36	huntingtin	Mus musculus	64-74
20533393-10	2010	These phenotypic changes were preceded by peak Hb-Hp levels observed at 2 h. CONCLUSION: We have shown for the first time, a phenotypic commitment of monocytes towards a protective CD14(pos)CD163(high)HLA-DR(low) population with increased intracellular HO-1 occurring in the circulation during the recovery phase of CPB.	cpb	316-319	CD14 molecule	Homo sapiens	181-185
20079914-5	2010	RESULTS: The post-CP/CPB contractile response of coronary arterioles to ET-1 was significantly decreased compared with the pre-CP/CPB responses.	cpb	21-24	endothelin 1	Homo sapiens	72-76
20079914-10	2010	CONCLUSION: CP/CPB decreases the contractile function of human coronary microvessels in responses to ET-1.	cpb	15-18	endothelin 1	Homo sapiens	101-105
18356657-5	2008	Compared with the conventional group, the mini-CPB group had lower levels of IL-8 on postoperative day 1 (8.3 +/- 6.4 vs. 19 +/- 11 pg/mL, p = 0.016) and of neutrophil elastase on postoperative days 1 (127 +/- 52 vs. 240 +/- 100 microg/L, p = 0.013) and 2 (107 +/- 17 vs. 170 +/- 45 micro/L, p = 0.0001).	cpb	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
19673331-11	2009	Blood ET-1 showed a figure of increasing as sICAM did (P < 0.05 or P < 0.01), and with a lower degree at 0.5-2 h after ending CPB in the treated group (P < 0.	cpb	132-135	endothelin 1	Homo sapiens	6-10
18706698-3	2008	We have recently shown that CPB is catalytically more efficient than plasma CPN, the major plasma anaphylatoxin inhibitor, in inhibiting bradykinin, activated complement C3a, C5a, and thrombin-cleaved osteopontin in vitro.	cpb	28-31	hemolytic complement	Mus musculus	175-178
18706698-3	2008	We have recently shown that CPB is catalytically more efficient than plasma CPN, the major plasma anaphylatoxin inhibitor, in inhibiting bradykinin, activated complement C3a, C5a, and thrombin-cleaved osteopontin in vitro.	cpb	28-31	coagulation factor II	Mus musculus	184-192
18706698-3	2008	We have recently shown that CPB is catalytically more efficient than plasma CPN, the major plasma anaphylatoxin inhibitor, in inhibiting bradykinin, activated complement C3a, C5a, and thrombin-cleaved osteopontin in vitro.	cpb	28-31	secreted phosphoprotein 1	Mus musculus	201-212
18706698-6	2008	Thus, our in vitro and in vivo data support the thesis that thrombin-activatable CPB has broad anti-inflammatory properties.	cpb	81-84	coagulation factor II	Mus musculus	60-68
18356657-5	2008	Compared with the conventional group, the mini-CPB group had lower levels of IL-8 on postoperative day 1 (8.3 +/- 6.4 vs. 19 +/- 11 pg/mL, p = 0.016) and of neutrophil elastase on postoperative days 1 (127 +/- 52 vs. 240 +/- 100 microg/L, p = 0.013) and 2 (107 +/- 17 vs. 170 +/- 45 micro/L, p = 0.0001).	cpb	47-50	elastase, neutrophil expressed	Homo sapiens	157-176
17418729-9	2007	Serum IL-6 and IL-10 concentrations increased after CPB when compared to the preoperative concentration.	cpb	52-55	interleukin 6	Homo sapiens	6-10
19025114-3	2008	We have recently shown that CPB is catalytically more efficient than plasma CPN, the major plasma anaphylatoxin inhibitor, in inhibiting bradykinin, activated complement C3a, C5a, and thrombin-cleaved osteopontin in vitro.	cpb	28-31	hemolytic complement	Mus musculus	175-178
19025114-3	2008	We have recently shown that CPB is catalytically more efficient than plasma CPN, the major plasma anaphylatoxin inhibitor, in inhibiting bradykinin, activated complement C3a, C5a, and thrombin-cleaved osteopontin in vitro.	cpb	28-31	coagulation factor II	Mus musculus	184-192
19025114-3	2008	We have recently shown that CPB is catalytically more efficient than plasma CPN, the major plasma anaphylatoxin inhibitor, in inhibiting bradykinin, activated complement C3a, C5a, and thrombin-cleaved osteopontin in vitro.	cpb	28-31	secreted phosphoprotein 1	Mus musculus	201-212
19025114-5	2008	Thus, our in vitro and in vivo data support the thesis that thrombin-activatable CPB has broad anti-inflammatory properties.	cpb	81-84	coagulation factor II	Mus musculus	60-68
18683667-3	2008	RESULTS: There was a very rapid upregulation of CD38 expression in "on-pump" patients, becoming significant at declamping of aorta (p<0.01) for myeloid cells and at the weaning from CPB (p<0.001) for lymphocytes.	cpb	185-188	CD38 molecule	Homo sapiens	48-52
17418729-9	2007	Serum IL-6 and IL-10 concentrations increased after CPB when compared to the preoperative concentration.	cpb	52-55	interleukin 10	Homo sapiens	15-20
17418729-11	2007	The IL-10 to IL-6 ratio was lower in the HLHS group preoperatively and immediately after CPB.	cpb	89-92	interleukin 10	Homo sapiens	4-9
17418729-11	2007	The IL-10 to IL-6 ratio was lower in the HLHS group preoperatively and immediately after CPB.	cpb	89-92	interleukin 6	Homo sapiens	13-17
16823956-11	2006	The numbers of CD34+CXCR4+ progenitor cells positively correlate with the plasma levels of SDF-1alpha post-CP/CPB, suggesting an important role of SDF-1alpha in progenitor cell mobilization.	cpb	110-113	C-X-C motif chemokine receptor 4	Homo sapiens	20-25
16823956-4	2006	The number of circulating CD34+CXCR4+ cells increased post-CP/CPB (442+/-53 versus 286+/-27; P=0.04 versus pre-CP/CPB), but not at POD4 (382+/-50; P=0.28 versus pre-CP/CPB).	cpb	62-65	CD34 molecule	Homo sapiens	26-30
16823956-4	2006	The number of circulating CD34+CXCR4+ cells increased post-CP/CPB (442+/-53 versus 286+/-27; P=0.04 versus pre-CP/CPB), but not at POD4 (382+/-50; P=0.28 versus pre-CP/CPB).	cpb	62-65	C-X-C motif chemokine receptor 4	Homo sapiens	31-36
16823956-4	2006	The number of circulating CD34+CXCR4+ cells increased post-CP/CPB (442+/-53 versus 286+/-27; P=0.04 versus pre-CP/CPB), but not at POD4 (382+/-50; P=0.28 versus pre-CP/CPB).	cpb	114-117	CD34 molecule	Homo sapiens	26-30
16823956-4	2006	The number of circulating CD34+CXCR4+ cells increased post-CP/CPB (442+/-53 versus 286+/-27; P=0.04 versus pre-CP/CPB), but not at POD4 (382+/-50; P=0.28 versus pre-CP/CPB).	cpb	114-117	C-X-C motif chemokine receptor 4	Homo sapiens	31-36
16823956-4	2006	The number of circulating CD34+CXCR4+ cells increased post-CP/CPB (442+/-53 versus 286+/-27; P=0.04 versus pre-CP/CPB), but not at POD4 (382+/-50; P=0.28 versus pre-CP/CPB).	cpb	114-117	CD34 molecule	Homo sapiens	26-30
16823956-4	2006	The number of circulating CD34+CXCR4+ cells increased post-CP/CPB (442+/-53 versus 286+/-27; P=0.04 versus pre-CP/CPB), but not at POD4 (382+/-50; P=0.28 versus pre-CP/CPB).	cpb	114-117	C-X-C motif chemokine receptor 4	Homo sapiens	31-36
16823956-6	2006	Plasma levels of vascular endothelial growth factor were similar post-CP/CPB (P=0.90 versus pre-CP/CPB) but increased at POD4 (220+/-40 pg/mL versus 134+/-26 pg/mL; P=0.04 versus pre-CP/CPB).	cpb	73-76	vascular endothelial growth factor A	Homo sapiens	17-51
16823956-6	2006	Plasma levels of vascular endothelial growth factor were similar post-CP/CPB (P=0.90 versus pre-CP/CPB) but increased at POD4 (220+/-40 pg/mL versus 134+/-26 pg/mL; P=0.04 versus pre-CP/CPB).	cpb	99-102	vascular endothelial growth factor A	Homo sapiens	17-51
16823956-6	2006	Plasma levels of vascular endothelial growth factor were similar post-CP/CPB (P=0.90 versus pre-CP/CPB) but increased at POD4 (220+/-40 pg/mL versus 134+/-26 pg/mL; P=0.04 versus pre-CP/CPB).	cpb	99-102	vascular endothelial growth factor A	Homo sapiens	17-51
16823956-7	2006	Serum levels of granulocyte-colony stimulating factor (G-CSF) increased early after CP/CPB as compared with pre-CP/CPB (265.0+/-41.7 versus 11.1+/-1.1 pg/mL; P<0.001) and returned to baseline at POD4 (P=0.84 versus pre-CP/CPB).	cpb	87-90	colony stimulating factor 3	Homo sapiens	16-53
16823956-7	2006	Serum levels of granulocyte-colony stimulating factor (G-CSF) increased early after CP/CPB as compared with pre-CP/CPB (265.0+/-41.7 versus 11.1+/-1.1 pg/mL; P<0.001) and returned to baseline at POD4 (P=0.84 versus pre-CP/CPB).	cpb	87-90	colony stimulating factor 3	Homo sapiens	55-60
16823956-8	2006	The circulating CD34+CXCR4+ cells were positively correlated with plasma levels of SDF-1alpha early after CP/CPB (r=0.56, P<0.01), but not at other times.	cpb	109-112	CD34 molecule	Homo sapiens	16-20
16823956-8	2006	The circulating CD34+CXCR4+ cells were positively correlated with plasma levels of SDF-1alpha early after CP/CPB (r=0.56, P<0.01), but not at other times.	cpb	109-112	C-X-C motif chemokine receptor 4	Homo sapiens	21-26
16823956-10	2006	CONCLUSIONS: Exposure to CP/CPB leads to an increase in circulating CD34+CXCR4+ progenitor cells, which is associated with increased myocardial SDF-1alpha expression.	cpb	28-31	CD34 molecule	Homo sapiens	68-72
16823956-10	2006	CONCLUSIONS: Exposure to CP/CPB leads to an increase in circulating CD34+CXCR4+ progenitor cells, which is associated with increased myocardial SDF-1alpha expression.	cpb	28-31	C-X-C motif chemokine receptor 4	Homo sapiens	73-78
17211353-4	2006	The aim of the study was to investigate if cardiopulmonary bypss (CPB) leads to more circulating HSP-70, on the basis of comparison dynamics of plasma concentration HSP-70 in 8 men undergoing procedures with the use of CPB (coronary artery bypass grafting, CABG group) and 8 men undergoing off-pump surgery (OPCAB group).	cpb	66-69	heat shock protein family A (Hsp70) member 4	Homo sapiens	97-103
17211353-4	2006	The aim of the study was to investigate if cardiopulmonary bypss (CPB) leads to more circulating HSP-70, on the basis of comparison dynamics of plasma concentration HSP-70 in 8 men undergoing procedures with the use of CPB (coronary artery bypass grafting, CABG group) and 8 men undergoing off-pump surgery (OPCAB group).	cpb	66-69	heat shock protein family A (Hsp70) member 4	Homo sapiens	165-171
17211353-11	2006	CONCLUSIONS: The use of CPB leads to significant more release of HSP-70 into the circulation.	cpb	24-27	heat shock protein family A (Hsp70) member 4	Homo sapiens	65-71
17670550-4	2006	The primary outcome measure was release of cardiac Troponin I (cTnI), measured at 6 time points from pre- to 72 h after the end of CPB.	cpb	131-134	troponin I3, cardiac type	Homo sapiens	43-61
16755443-3	2006	Thus, we hypothesized that eNOS gene polymorphism could influence perioperative hemodynamics and catecholamine support in patients undergoing cardiac surgery with CPB.	cpb	163-166	nitric oxide synthase 3	Homo sapiens	27-31
16140032-3	2005	In the present study, a metabolic flux model was constructed for two recombinant S. cerevisiae strains: TMB3001 and CPB.CR4 which in addition to xylose metabolism have a modulated redox metabolism, i.e. ammonia assimilation was shifted from being NADPH to NADH dependent by deletion of gdh1 and over-expression of GDH2.	cpb	116-119	glutamate dehydrogenase (NADP(+)) GDH1	Saccharomyces cerevisiae S288C	286-290
16505984-2	2006	The electrochemical behaviors of CAT and HQ in aqueous CPB and SDBS micellar solutions have been studied by cyclic voltammetry.	cpb	55-58	catalase	Homo sapiens	33-36
16505984-3	2006	The oxidation peak potentials shift negatively, the reduction peak potentials shift positively, and the peak currents increase in the presence of CPB for both CAT and HQ.	cpb	146-149	catalase	Homo sapiens	159-162
16505984-5	2006	The electrochemical kinetic parameters for CAT and HQ in aqueous CPB and SDBS micellar solutions were also determined by chronocoulometry (CC) and chronoamperometry (CA).	cpb	65-68	catalase	Homo sapiens	43-46
16505984-7	2006	It was found that the oxidation peak potential waves of CAT and HQ were separated by 100 mV in the presence of CPB in 0.10 M PBS (pH 6.8).	cpb	111-114	catalase	Homo sapiens	56-59
16823956-11	2006	The numbers of CD34+CXCR4+ progenitor cells positively correlate with the plasma levels of SDF-1alpha post-CP/CPB, suggesting an important role of SDF-1alpha in progenitor cell mobilization.	cpb	110-113	CD34 molecule	Homo sapiens	15-19
16427874-6	2006	The C3a value was also lower at 2 hours later in the off-pump group than in the CPB group.	cpb	80-83	complement C3	Homo sapiens	4-7
16140032-3	2005	In the present study, a metabolic flux model was constructed for two recombinant S. cerevisiae strains: TMB3001 and CPB.CR4 which in addition to xylose metabolism have a modulated redox metabolism, i.e. ammonia assimilation was shifted from being NADPH to NADH dependent by deletion of gdh1 and over-expression of GDH2.	cpb	116-119	glutamate dehydrogenase (NAD(+))	Saccharomyces cerevisiae S288C	314-318
16042874-7	2005	The plasma level of NSE increased more significantly in the CHD group than in the RHD group 20 minutes after CPB and it returned to the normal level 24 hours after CPB in the CHD group but remained at a high level in the RHD group (P < 0.01).	cpb	109-112	enolase 2	Homo sapiens	20-23
16042874-7	2005	The plasma level of NSE increased more significantly in the CHD group than in the RHD group 20 minutes after CPB and it returned to the normal level 24 hours after CPB in the CHD group but remained at a high level in the RHD group (P < 0.01).	cpb	164-167	enolase 2	Homo sapiens	20-23
15936311-10	2005	CONCLUSION: Compared with cTn-I and CK-MB, H-FABP is an earlier and potentially useful marker in the rapid evaluation of myocardial damage following valve replacement surgery with CPB.	cpb	180-183	fatty acid binding protein 3	Homo sapiens	43-49
15613277-7	2005	Increase of TNF-alpha, interleukin-10 and soluble TNF-receptor I after CPB may be involved in the pathogenesis of stroke after CPB.	cpb	71-74	tumor necrosis factor	Homo sapiens	12-21
15995588-7	2005	RESULTS: During the course of the operation, CD11b molecule expression on neutrophils showed a slight elevation at the start of CPB (876.5+/-104.8 mean fluorescence intensity, MFI, vs. 768.1+/-178.2; p = 0.0047), followed by a significant decrease to 689.01+/-166.7 MFI after completion of the procedure.	cpb	128-131	integrin subunit alpha M	Homo sapiens	45-50
15995588-8	2005	The expression of CD11b molecule on neutrophils measured at the end of CPB inversely correlated with the duration of CPB (r = -0.68, p = 0.00059).	cpb	71-74	integrin subunit alpha M	Homo sapiens	18-23
15995588-8	2005	The expression of CD11b molecule on neutrophils measured at the end of CPB inversely correlated with the duration of CPB (r = -0.68, p = 0.00059).	cpb	117-120	integrin subunit alpha M	Homo sapiens	18-23
15995588-9	2005	The expression of CD16 antigen dropped significantly at the start of CPB (1164.6+/-307.3 MFI vs. 1327.4+/-345.3 MFI; p = 0.0007) and remained decreased until the end of CPB (814.0+/-198.1 MFI).	cpb	69-72	Fc gamma receptor IIIa	Homo sapiens	18-22
15995588-9	2005	The expression of CD16 antigen dropped significantly at the start of CPB (1164.6+/-307.3 MFI vs. 1327.4+/-345.3 MFI; p = 0.0007) and remained decreased until the end of CPB (814.0+/-198.1 MFI).	cpb	169-172	Fc gamma receptor IIIa	Homo sapiens	18-22
15613277-7	2005	Increase of TNF-alpha, interleukin-10 and soluble TNF-receptor I after CPB may be involved in the pathogenesis of stroke after CPB.	cpb	127-130	tumor necrosis factor	Homo sapiens	12-21
15613277-7	2005	Increase of TNF-alpha, interleukin-10 and soluble TNF-receptor I after CPB may be involved in the pathogenesis of stroke after CPB.	cpb	127-130	interleukin 10	Homo sapiens	23-37
11347983-8	2001	IL-8 and IL-10 levels were significantly higher in the CPB than in the off-pump patients after reperfusion (p=0.006 and 0.001 respectively).	cpb	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15644260-4	2005	Life cycle assessment or LCA will be introduced in this paper as a useful tool to compare the environmental performance of both EPS and CPB throughout their life cycle stages.	cpb	136-139	clathrin light chain A	Homo sapiens	25-28
15370104-8	2004	In conclusion, we have demonstrated that normal preoperative TEG-MA does not preclude clopidogrel-induced ADP receptor blockade; however, TEG can be a reliable monitor for CPB-induced platelet dysfunction related to GPIIb/IIIa.	cpb	172-175	integrin subunit alpha 2b	Homo sapiens	216-221
12702906-3	2003	RESULTS: A normal cortisol response to corticotropin-releasing hormone (CRH) stimulation was demonstrated in 57.6% of CPA patients, 31.1% of CPB patients and 20% of CPC patients, while basal levels of adrenocorticotropic hormone (ACTH) and cortisol in cirrhotics were comparable to those in controls.	cpb	141-144	corticotropin releasing hormone	Homo sapiens	39-70
12702906-3	2003	RESULTS: A normal cortisol response to corticotropin-releasing hormone (CRH) stimulation was demonstrated in 57.6% of CPA patients, 31.1% of CPB patients and 20% of CPC patients, while basal levels of adrenocorticotropic hormone (ACTH) and cortisol in cirrhotics were comparable to those in controls.	cpb	141-144	corticotropin releasing hormone	Homo sapiens	72-75
12527621-3	2003	We hypothesized that Na(+)/H(+) exchanger inhibition with a selective inhibitor (EMD 87580) would decrease myocardial edema and improve myocardial performance after CPB/CPA.	cpb	165-168	solute carrier family 9 member A1	Canis lupus familiaris	21-41
12417066-4	2002	TNF-alpha increased more significantly in the patients with CPB than in those without CPB after operation [(4.10 +/- 0.71) pg/ml vs. (1.34 +/- 0.29) pg/ml, P < 0.05)].	cpb	60-63	tumor necrosis factor	Homo sapiens	0-9
12417066-4	2002	TNF-alpha increased more significantly in the patients with CPB than in those without CPB after operation [(4.10 +/- 0.71) pg/ml vs. (1.34 +/- 0.29) pg/ml, P < 0.05)].	cpb	86-89	tumor necrosis factor	Homo sapiens	0-9
12417066-6	2002	CRP was higher in the CAD patients with CPB than in the control group after operation [(12.89 +/- 0.29) pg/ml vs. (12.00 +/- 0.31) pg/ml, P < 0.05].	cpb	40-43	C-reactive protein	Homo sapiens	0-3
12658745-10	2002	The activity of caspase-3 and the content of lipid peroxide in LV myocardium in CPB group were also significantly increased after CPB.	cpb	80-83	caspase 3	Canis lupus familiaris	16-25
12658745-10	2002	The activity of caspase-3 and the content of lipid peroxide in LV myocardium in CPB group were also significantly increased after CPB.	cpb	130-133	caspase 3	Canis lupus familiaris	16-25
12658745-12	2002	Moreover, the CPB-induced myocyte apoptosis was associated with upregulation of expressions of bax and bad proteins, activation of caspase-3 and increase of oxidative stress.	cpb	14-17	BCL2 associated X, apoptosis regulator	Canis lupus familiaris	95-98
12658745-12	2002	Moreover, the CPB-induced myocyte apoptosis was associated with upregulation of expressions of bax and bad proteins, activation of caspase-3 and increase of oxidative stress.	cpb	14-17	caspase 3	Canis lupus familiaris	131-140
11575835-6	2001	In group OD, pHi was significantly decreased at OD10 (7.35 +/- 0.03 at CPB30 vs. 7.23 +/- 0.07 at OD10, p < 0.05) but recovered by the end of CPB (7.32 +/- 0.02).	cpb	71-74	glucose-6-phosphate isomerase	Homo sapiens	13-16
15649795-2	2005	In Tris-NaOH (pH = 10.93) buffer, the RLS of rutin-cetylpyridine bromide (CPB) system can be greatly enhanced by protein, including bovine serum albumin (BSA) and human serum albumin (HSA).	cpb	74-77	albumin	Homo sapiens	139-158
15649795-2	2005	In Tris-NaOH (pH = 10.93) buffer, the RLS of rutin-cetylpyridine bromide (CPB) system can be greatly enhanced by protein, including bovine serum albumin (BSA) and human serum albumin (HSA).	cpb	74-77	albumin	Homo sapiens	139-152
12970258-14	2003	Myocardial MKP-1 gene expression increased post-C/CPB (3.0+/-0.8, post/pre-C/CPB ratio, P<0.05, n=5).	cpb	50-53	dual specificity phosphatase 1	Homo sapiens	11-16
12970258-14	2003	Myocardial MKP-1 gene expression increased post-C/CPB (3.0+/-0.8, post/pre-C/CPB ratio, P<0.05, n=5).	cpb	77-80	dual specificity phosphatase 1	Homo sapiens	11-16
12970258-18	2003	The ERK1/2 signal transduction pathway in part mediates coronary microvascular dysfunction after C/CPB in humans.	cpb	99-102	mitogen-activated protein kinase 3	Homo sapiens	4-10
11789776-5	2001	RESULTS: The plasma levels of neutrophil elastase and IL-8 were inhibited in the C groups at 2 hours after CPB termination.	cpb	107-110	elastase, neutrophil expressed	Homo sapiens	30-49
11347983-8	2001	IL-8 and IL-10 levels were significantly higher in the CPB than in the off-pump patients after reperfusion (p=0.006 and 0.001 respectively).	cpb	55-58	interleukin 10	Homo sapiens	9-14
12212211-4	2000	RESULTS: A significant(P < 0.05) increase of TNF-alpha occurred in all three groups at 2 and 24 hours after CPB termination when compared with the same group at baseline.	cpb	111-114	tumor necrosis factor	Homo sapiens	48-57
11246985-9	2001	The expression of TF and IL-1 beta, however, was not significantly different in group A, B and C. These findings indicate that thrombin function intimately participates in the development of pulmonary ischemia-reperfusion injury during CPB.	cpb	236-239	prothrombin	Oryctolagus cuniculus	127-135
11246985-10	2001	In addition, the anti-thrombin treatment would be an effective therapeutical tool for the prevention of not only activation of extrinsic coagulation pathway but also its sequential inflammatory and circulatory disturbance in ischemia-reperfusion injury of lung during CPB.	cpb	268-271	prothrombin	Oryctolagus cuniculus	22-30
12212211-5	2000	In Group A, TNF-alpha level was significantly lower than that in group C(P < 0.05) at 24 hours after CPB, but not in group B(P > 0.05).	cpb	104-107	tumor necrosis factor	Homo sapiens	12-21
1552659-7	1992	Level of C3a increased significantly 10 min after initiation of CPB, and gradually increased till immediately after the end of CPB, when the level was maximum (4625 +/- 560 ng.ml-1) among 7 points.	cpb	64-67	complement C3	Homo sapiens	9-12
12845731-8	2000	It is concluded that the immunity depression after CPB is associated with low level of IL-2 and high level of sIL-2R and aprotinin can ameliorate the situation.	cpb	51-54	interleukin 2	Homo sapiens	87-91
10232597-13	1999	to sham-operated and castrated Cpb:WU rats resulted in 2- and 38-fold increases in ODC activity, respectively, in the ventral prostate.	cpb	31-34	ornithine decarboxylase 1	Rattus norvegicus	83-86
10072808-4	1997	RESULTS: In 19 VSD patients with CPB, SatPC/TPL was significantly decreased from 48% to 34% (t = 2.737, P < 0.05), SatPC/TP decreased from 64 to 33 mg/g (t = 3.011, P < 0.01), and SP-A from 23 to 11mg/g (t = 2.987, P < 0.01).	cpb	33-36	surfactant protein A1	Homo sapiens	186-190
8662763-13	1996	The complex between human alpha2M and plasma CPB dissociated during SDS-polyacrylamide gel electrophoresis and transverse urea gel electrophoresis suggesting that the interaction was noncovalent and depended on the tertiary structure of the native alpha2M molecule.	cpb	45-48	alpha-2-macroglobulin	Homo sapiens	26-33
8662763-13	1996	The complex between human alpha2M and plasma CPB dissociated during SDS-polyacrylamide gel electrophoresis and transverse urea gel electrophoresis suggesting that the interaction was noncovalent and depended on the tertiary structure of the native alpha2M molecule.	cpb	45-48	alpha-2-macroglobulin	Homo sapiens	248-255
7699821-4	1995	IL-8 increased significantly after the start of CPB and reached a peak at 10 minutes after release of the aortic cross-clamp, remaining significantly elevated until 10 minutes after the end of CPB (P < 0.05).	cpb	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7699821-4	1995	IL-8 increased significantly after the start of CPB and reached a peak at 10 minutes after release of the aortic cross-clamp, remaining significantly elevated until 10 minutes after the end of CPB (P < 0.05).	cpb	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7699821-7	1995	This study demonstrates elevated TNF alpha and IL-8 levels during CPB followed by increases of the neutrophil and the granulocyte elastase, which may be of importance in the systemic inflammatory response to CPB, especially in the development of postperfusion lung injury.	cpb	66-69	tumor necrosis factor	Homo sapiens	33-42
7699821-7	1995	This study demonstrates elevated TNF alpha and IL-8 levels during CPB followed by increases of the neutrophil and the granulocyte elastase, which may be of importance in the systemic inflammatory response to CPB, especially in the development of postperfusion lung injury.	cpb	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
10537578-8	1998	However, significant reduction in CTD (p = 0.05) was seen in the aminocaproic acid patients who were treated with ATIII pre-CPB or within the first 20 minutes of CPB.	cpb	124-127	CTD	Homo sapiens	34-37
10537578-8	1998	However, significant reduction in CTD (p = 0.05) was seen in the aminocaproic acid patients who were treated with ATIII pre-CPB or within the first 20 minutes of CPB.	cpb	124-127	serpin family C member 1	Homo sapiens	114-119
8562836-3	1995	The collagen binding assay employs the affinity of the high-molecular-weight multimers of vWF to collagen and was used in this study to demonstrate differences in the multimeric composition of vWF during and after CPB.	cpb	214-217	von Willebrand factor	Homo sapiens	193-196
7944696-4	1994	Increases were found in beta-thromboglobulin and platelet factor 4 concentrations at 10 (p < 0.03) and 30 minutes (p < 0.001) of CPB, respectively, and continuing throughout CPB (p < 0.001) for both groups versus values measured before incision.	cpb	135-138	pro-platelet basic protein	Homo sapiens	24-44
7944696-4	1994	Increases were found in beta-thromboglobulin and platelet factor 4 concentrations at 10 (p < 0.03) and 30 minutes (p < 0.001) of CPB, respectively, and continuing throughout CPB (p < 0.001) for both groups versus values measured before incision.	cpb	180-183	pro-platelet basic protein	Homo sapiens	24-44
1552659-7	1992	Level of C3a increased significantly 10 min after initiation of CPB, and gradually increased till immediately after the end of CPB, when the level was maximum (4625 +/- 560 ng.ml-1) among 7 points.	cpb	127-130	complement C3	Homo sapiens	9-12
1552659-12	1992	C3a increased significantly from 10 min after initiation of CPB to 120 min after end of CPB, but C5a was not detected at all during the whole course.	cpb	60-63	complement C3	Homo sapiens	0-3