PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33584305-7	2020	Moreover, mitotic cell death induced by the combined treatment was suppressed by the Mps1 inhibitor, reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	101-110	TTK protein kinase	Homo sapiens	85-89
33450295-0	2021	Reversine suppresses osteosarcoma cell growth through targeting BMP-Smad1/5/8-mediated angiogenesis.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	SMAD family member 1	Gallus gallus	68-77
33450295-10	2021	Lastly, qPCR and western blot analyses showed BMP-associated Smad1/5/8 signaling expressions were up-regulated by Reversine treatment.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	114-123	SMAD family member 1	Gallus gallus	61-70
32857324-4	2020	Reversine is a synthetic purine analog that acts as a multi-kinase inhibitor with anti-neoplastic activity by targeting AURKA and AURKB.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase A	Homo sapiens	120-125
33505802-0	2021	Reversine, a selective MPS1 inhibitor, induced autophagic cell death via diminished glucose uptake and ATP production in cholangiocarcinoma cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	TTK protein kinase	Homo sapiens	23-27
33505802-1	2021	Reversine is a selective inhibitor of mitotic kinase monopolar spindle 1 (MPS1) and has been reported as an anticancer agent in various cancers.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	TTK protein kinase	Homo sapiens	74-78
33505802-4	2021	Reversine also triggered apoptotic cell death by decreasing anti-apoptotic proteins, Bcl-XL and Mcl-1, increasing Bax pro-apoptotic protein and activating caspase-3 activity.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	BCL2 like 1	Homo sapiens	85-91
33505802-4	2021	Reversine also triggered apoptotic cell death by decreasing anti-apoptotic proteins, Bcl-XL and Mcl-1, increasing Bax pro-apoptotic protein and activating caspase-3 activity.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	96-101
33505802-4	2021	Reversine also triggered apoptotic cell death by decreasing anti-apoptotic proteins, Bcl-XL and Mcl-1, increasing Bax pro-apoptotic protein and activating caspase-3 activity.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	114-117
33505802-4	2021	Reversine also triggered apoptotic cell death by decreasing anti-apoptotic proteins, Bcl-XL and Mcl-1, increasing Bax pro-apoptotic protein and activating caspase-3 activity.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	caspase 3	Homo sapiens	155-164
33505802-5	2021	Moreover, reversine induced autophagic cell death by increasing LC3-II and Beclin 1 while decreasing p62.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	10-19	beclin 1	Homo sapiens	75-83
33505802-5	2021	Moreover, reversine induced autophagic cell death by increasing LC3-II and Beclin 1 while decreasing p62.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	10-19	nucleoporin 62	Homo sapiens	101-104
33505802-7	2021	Additionally, this study demonstrated for the first time that reversine could diminish the expression of Hypoxia-Inducible Factor 1- alpha (HIF-1alpha) and glucose transporter 1 (GLUT1), resulting in a reduction of glucose uptake and energy production in CCA cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	62-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-138
33505802-7	2021	Additionally, this study demonstrated for the first time that reversine could diminish the expression of Hypoxia-Inducible Factor 1- alpha (HIF-1alpha) and glucose transporter 1 (GLUT1), resulting in a reduction of glucose uptake and energy production in CCA cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	62-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-150
33505802-7	2021	Additionally, this study demonstrated for the first time that reversine could diminish the expression of Hypoxia-Inducible Factor 1- alpha (HIF-1alpha) and glucose transporter 1 (GLUT1), resulting in a reduction of glucose uptake and energy production in CCA cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	62-71	solute carrier family 2 member 1	Homo sapiens	156-177
33505802-7	2021	Additionally, this study demonstrated for the first time that reversine could diminish the expression of Hypoxia-Inducible Factor 1- alpha (HIF-1alpha) and glucose transporter 1 (GLUT1), resulting in a reduction of glucose uptake and energy production in CCA cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	62-71	solute carrier family 2 member 1	Homo sapiens	179-184
32857324-4	2020	Reversine is a synthetic purine analog that acts as a multi-kinase inhibitor with anti-neoplastic activity by targeting AURKA and AURKB.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase B	Homo sapiens	130-135
32456791-6	2020	In addition, the decreased ratio of LC3II/LC3I as well as elevated p62 expression were observed under reversine treatment, indicating the autophagy inhibition by reversine in HepG2 cell line.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	102-111	nucleoporin 62	Homo sapiens	67-70
32226250-13	2020	Real-time PCR analysis showed that after addition of 600 nM of reversine significantly increased nanog expression compared to other treatments.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	63-72	Nanog homeobox	Homo sapiens	97-102
30976094-5	2019	Finally, we used the champion inhibitor (NH-23-C2) in reversine-treated HCT-116 colon cancer cells to selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	54-63	MDM2 proto-oncogene	Homo sapiens	162-167
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	matrix metallopeptidase 3	Homo sapiens	19-24
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	interleukin 6	Homo sapiens	26-30
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	mitogen-activated protein kinase 8	Homo sapiens	82-85
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	interleukin 1 beta	Homo sapiens	105-122
31470141-5	2019	We examined the preventive effects of reversine, a 2,6-disubstituted purine derivative, on cytokine and MMP-3 expression in human gingival fibroblasts (HGFs) stimulated with IL-lbeta.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	38-47	matrix metallopeptidase 3	Homo sapiens	104-109
30976094-0	2019	Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	68-77	caspase 2	Homo sapiens	21-30
30976094-0	2019	Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	68-77	MDM2 proto-oncogene	Homo sapiens	50-55
30976094-5	2019	Finally, we used the champion inhibitor (NH-23-C2) in reversine-treated HCT-116 colon cancer cells to selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	54-63	caspase 2	Homo sapiens	120-129
31289316-8	2019	Synergism experiments indicated that low dose of reversine had a potentiating effect under ruxolitinib treatment at low doses in SET2 cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	49-58	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	129-133
30976094-5	2019	Finally, we used the champion inhibitor (NH-23-C2) in reversine-treated HCT-116 colon cancer cells to selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	54-63	caspase 2	Homo sapiens	143-152
31244554-2	2019	Even though 2-(4-morpholinoanilino)-6-cyclohexylaminopurine (reversine) is an aurora kinase inhibitor, it also inhibits some cancer cells and human BRCA cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	12-59	BRCA1 DNA repair associated	Homo sapiens	148-152
31244554-2	2019	Even though 2-(4-morpholinoanilino)-6-cyclohexylaminopurine (reversine) is an aurora kinase inhibitor, it also inhibits some cancer cells and human BRCA cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	61-70	BRCA1 DNA repair associated	Homo sapiens	148-152
31244554-12	2019	Results: Reversine inhibits cell proliferation and induces cell apoptosis by modulating caspase-3 and bax/bcl-2 among the three cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	9-18	caspase 3	Homo sapiens	88-97
31244554-12	2019	Results: Reversine inhibits cell proliferation and induces cell apoptosis by modulating caspase-3 and bax/bcl-2 among the three cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	9-18	BCL2 associated X, apoptosis regulator	Homo sapiens	102-105
31244554-12	2019	Results: Reversine inhibits cell proliferation and induces cell apoptosis by modulating caspase-3 and bax/bcl-2 among the three cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	9-18	BCL2 apoptosis regulator	Homo sapiens	106-111
31244554-17	2019	The tumor-related proteins TGF-beta1, TIMP1, and MMP9 are partially suppressed by reversine but with different sensitivity in the three cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	82-91	transforming growth factor beta 1	Homo sapiens	27-36
31244554-17	2019	The tumor-related proteins TGF-beta1, TIMP1, and MMP9 are partially suppressed by reversine but with different sensitivity in the three cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	82-91	TIMP metallopeptidase inhibitor 1	Homo sapiens	38-43
31244554-17	2019	The tumor-related proteins TGF-beta1, TIMP1, and MMP9 are partially suppressed by reversine but with different sensitivity in the three cell lines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	82-91	matrix metallopeptidase 9	Homo sapiens	49-53
31244554-20	2019	Reversine contributes to anti-growth effect in BRCA cell lines, especially for TNBC, by modulating the aurora B.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	BRCA1 DNA repair associated	Homo sapiens	47-51
31244554-20	2019	Reversine contributes to anti-growth effect in BRCA cell lines, especially for TNBC, by modulating the aurora B.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase B	Homo sapiens	103-111
31083605-8	2019	These advances prompted us to study the potential sensitising effect of chitosan-based nanoparticles on breast cancer cells treated with reversine, which is a small molecule inhibitor of Mps1 and Aurora B that induces premature exit from mitosis, aneuploidy, and cell death, before and after exposure of the cancer cells to X-ray irradiation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	137-146	macrophage expressed 1	Homo sapiens	187-191
30953339-6	2019	Reversine-treated cells showed caspase-3/7 activation and increased apoptosis versus control cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	caspase 3	Homo sapiens	31-40
30953339-7	2019	FasL, a death ligand associated with extrinsic apoptotic signaling pathways, was significantly up-regulated by reversine treatment.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	111-120	Fas ligand	Homo sapiens	0-4
30953339-8	2019	Moreover, the caspase-8, a part of the extrinsic apoptotic pathway, was activated by reversine treatments.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	85-94	caspase 8	Homo sapiens	14-23
30953339-9	2019	Expressions of anti-apoptotic factors such as Bcl-2 and Bcl-xL, components of the mitochondria dependent intrinsic apoptosis pathway, significantly decreased following reversine treatment.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	168-177	BCL2 apoptosis regulator	Homo sapiens	46-51
30953339-9	2019	Expressions of anti-apoptotic factors such as Bcl-2 and Bcl-xL, components of the mitochondria dependent intrinsic apoptosis pathway, significantly decreased following reversine treatment.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	168-177	BCL2 like 1	Homo sapiens	56-62
30953339-10	2019	The expressions of pro-apoptotic factors such as BAX, BAD and caspase-9 increased by reversine treatments.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	85-94	BCL2 associated X, apoptosis regulator	Homo sapiens	49-52
30953339-10	2019	The expressions of pro-apoptotic factors such as BAX, BAD and caspase-9 increased by reversine treatments.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	85-94	caspase 9	Homo sapiens	62-71
30953339-12	2019	The Z-VAD-fmk significantly inhibited cell death through the suppression of caspase-3 expression in MG-63 cells treated with reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	125-134	caspase 3	Homo sapiens	76-85
31083605-8	2019	These advances prompted us to study the potential sensitising effect of chitosan-based nanoparticles on breast cancer cells treated with reversine, which is a small molecule inhibitor of Mps1 and Aurora B that induces premature exit from mitosis, aneuploidy, and cell death, before and after exposure of the cancer cells to X-ray irradiation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	137-146	aurora kinase B	Homo sapiens	196-204
30132867-5	2019	Reversine treatment promoted the expression of brown adipocyte marker genes, such as Prdm16 and UCP1, increasing the mitochondrial content, while decreasing the levels of miR-133a and white adipocyte marker genes.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	PR domain containing 16	Mus musculus	85-91
30864676-0	2019	Reversine induces cell cycle arrest and apoptosis via upregulation of the Fas and DR5 signaling pathways in human colorectal cancer cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	TNF receptor superfamily member 10b	Homo sapiens	82-85
30864676-10	2019	Reversine-induced apoptosis and cell cycle arrest were suppressed by inhibition of Fas and DR5 expression via siRNA.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	TNF receptor superfamily member 10b	Homo sapiens	91-94
30132867-5	2019	Reversine treatment promoted the expression of brown adipocyte marker genes, such as Prdm16 and UCP1, increasing the mitochondrial content, while decreasing the levels of miR-133a and white adipocyte marker genes.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	96-100
30132867-8	2019	Taken together, we found a novel way to promote browning of white adipocytes through downregulation of miR-133a followed by activation of Prdm16, with a synthetic chemical, reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	173-182	PR domain containing 16	Mus musculus	138-144
28726638-4	2017	Here we characterize the interactions of two such mutants, Mps1 C604Y and C604W, which raise resistance to two closely related compounds, NMS-P715 and its derivative Cpd-5, but not to the well characterized Mps1 inhibitor, reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	223-232	TTK protein kinase	Homo sapiens	59-63
30087398-0	2018	Reversine inhibits Colon Carcinoma Cell Migration by Targeting JNK1.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	mitogen-activated protein kinase 8	Homo sapiens	63-67
30087398-5	2018	A coupled kinase assay with bio-informatics approach identified the c-Jun N-terminal kinase (JNK) cascade as the main pathway inhibited by Reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	139-148	mitogen-activated protein kinase 8	Homo sapiens	68-91
30087398-5	2018	A coupled kinase assay with bio-informatics approach identified the c-Jun N-terminal kinase (JNK) cascade as the main pathway inhibited by Reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	139-148	mitogen-activated protein kinase 8	Homo sapiens	93-96
30087398-8	2018	These results highlight the impact of individual JNK isoforms in cancer cell metastasis and propose Reversine as a novel anti-cancer molecule for treatment of colon cancer patients.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	100-109	mitogen-activated protein kinase 8	Homo sapiens	49-52
30103421-7	2018	Therefore, our findings support a potential selective role of these structurally simplified, reversine-related molecules in p53-defective cancer cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	93-102	tumor protein p53	Homo sapiens	124-127
29925769-3	2018	Recently, three potential small-molecule inhibitors of Mps1 (i.e., reversine, NMS-P715, and its derivative Cpd-5) were reported for the C604Y mutation that exhibit significant resistance to NMS-P715 and Cpd-5, but retain affinity for reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	67-76	TTK protein kinase	Homo sapiens	55-59
29925769-3	2018	Recently, three potential small-molecule inhibitors of Mps1 (i.e., reversine, NMS-P715, and its derivative Cpd-5) were reported for the C604Y mutation that exhibit significant resistance to NMS-P715 and Cpd-5, but retain affinity for reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	234-243	TTK protein kinase	Homo sapiens	55-59
29341262-0	2018	Reversine inhibits MMP-1 and MMP-3 expressions by suppressing of ROS/MAPK/AP-1 activation in UV-stimulated human keratinocytes and dermal fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	matrix metallopeptidase 1	Homo sapiens	19-24
29341262-0	2018	Reversine inhibits MMP-1 and MMP-3 expressions by suppressing of ROS/MAPK/AP-1 activation in UV-stimulated human keratinocytes and dermal fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	matrix metallopeptidase 3	Homo sapiens	29-34
29341262-0	2018	Reversine inhibits MMP-1 and MMP-3 expressions by suppressing of ROS/MAPK/AP-1 activation in UV-stimulated human keratinocytes and dermal fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-78
29341262-3	2018	We examined the preventive effects of reversine on MMP-1 and MMP-3 expressions in NHEKs and NHDFs exposed to UVB irradiation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	38-47	matrix metallopeptidase 1	Homo sapiens	51-56
29341262-3	2018	We examined the preventive effects of reversine on MMP-1 and MMP-3 expressions in NHEKs and NHDFs exposed to UVB irradiation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	38-47	matrix metallopeptidase 3	Homo sapiens	61-66
29341262-5	2018	The mechanism underlying the MMP inhibitory effects of reversine occurred via the suppression of UVB-induced ROS generation and MAPK/AP-1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	55-64	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	133-137
27734224-7	2016	Reversine inhibited the activation of HSCs through TGF-beta signaling pathway and degraded extracellular matrix protein collagen-I.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	transforming growth factor beta 1	Homo sapiens	51-59
28415765-8	2017	Finally, we confirm that the reference compound reversine is a TTK inhibitor and like NTRC 0066-0, inhibits the proliferation of patient-derived colorectal cancer organoids.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	48-57	TTK protein kinase	Homo sapiens	63-66
28463842-10	2017	The effects of each, Ca2+ loading, energy depletion and oxidative stress on annexin-V-binding were significantly blunted in the presence of reversine (1-10 microM).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	140-149	annexin A5	Homo sapiens	76-85
27699881-4	2016	Mps1 kinase inhibitors include reversine (2-(4-morpholinoanilino)-6-cyclohexylaminopurine), a promiscuous compound first recognized as an inhibitor of the Aurora B mitotic kinase.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	31-40	TTK protein kinase	Homo sapiens	0-4
27699881-4	2016	Mps1 kinase inhibitors include reversine (2-(4-morpholinoanilino)-6-cyclohexylaminopurine), a promiscuous compound first recognized as an inhibitor of the Aurora B mitotic kinase.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	31-40	aurora kinase B	Homo sapiens	155-163
27699881-4	2016	Mps1 kinase inhibitors include reversine (2-(4-morpholinoanilino)-6-cyclohexylaminopurine), a promiscuous compound first recognized as an inhibitor of the Aurora B mitotic kinase.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	42-89	TTK protein kinase	Homo sapiens	0-4
27699881-4	2016	Mps1 kinase inhibitors include reversine (2-(4-morpholinoanilino)-6-cyclohexylaminopurine), a promiscuous compound first recognized as an inhibitor of the Aurora B mitotic kinase.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	42-89	aurora kinase B	Homo sapiens	155-163
27699881-6	2016	Structural comparison of reversine bound to Mps1 and Aurora B, indicates a similar binding pose for the purine moiety of reversine making three conserved hydrogen bonds to the protein main chain, explaining the observed promiscuity of this inhibitor.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	25-34	TTK protein kinase	Homo sapiens	44-48
27699881-6	2016	Structural comparison of reversine bound to Mps1 and Aurora B, indicates a similar binding pose for the purine moiety of reversine making three conserved hydrogen bonds to the protein main chain, explaining the observed promiscuity of this inhibitor.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	25-34	aurora kinase B	Homo sapiens	53-61
23475158-3	2013	The inhibition rate of reversine and aspirin on cervical cancer cell lines" (HeLa and U14) was determined by MTT method, cell cycle of HeLa and U14 cells was analyzed by FACS, mitochondrial membrane potential of HeLa and U14 was detected using a JC-1 kit.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	23-32	small nucleolar RNA, C/D box 14A	Homo sapiens	86-89
27447890-4	2016	In the present study, we explored the cellular effects of reversine, an AURKA and AURKB inhibitor, in the BCR-ABL1+ K562 cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	58-67	aurora kinase A	Homo sapiens	72-77
27447890-4	2016	In the present study, we explored the cellular effects of reversine, an AURKA and AURKB inhibitor, in the BCR-ABL1+ K562 cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	58-67	aurora kinase B	Homo sapiens	82-87
27447890-4	2016	In the present study, we explored the cellular effects of reversine, an AURKA and AURKB inhibitor, in the BCR-ABL1+ K562 cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	58-67	BCR activator of RhoGEF and GTPase	Homo sapiens	106-114
27447890-5	2016	Our results indicate that reversine reduces AURKA and AURKB expression, leads to reduction of cell viability and increased apoptosis in a dose- and time-dependent manner, as well as, induces mitotic catastrophe in K562 cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	26-35	aurora kinase A	Homo sapiens	44-49
27447890-5	2016	Our results indicate that reversine reduces AURKA and AURKB expression, leads to reduction of cell viability and increased apoptosis in a dose- and time-dependent manner, as well as, induces mitotic catastrophe in K562 cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	26-35	aurora kinase B	Homo sapiens	54-59
26722217-5	2016	However, molecular and cellular experiments suggested that reversine treatment enhanced selectively the expression of pluripotent marker gene Oct4 and mesenchymal marker genes CD29, CD44 and CD73, but Sox2 and Nanog were not detected.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	59-68	POU domain, class 5, transcription factor 1	Bos taurus	142-146
26722217-5	2016	However, molecular and cellular experiments suggested that reversine treatment enhanced selectively the expression of pluripotent marker gene Oct4 and mesenchymal marker genes CD29, CD44 and CD73, but Sox2 and Nanog were not detected.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	59-68	CD44 molecule	Bos taurus	182-186
26722217-5	2016	However, molecular and cellular experiments suggested that reversine treatment enhanced selectively the expression of pluripotent marker gene Oct4 and mesenchymal marker genes CD29, CD44 and CD73, but Sox2 and Nanog were not detected.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	59-68	SRY-box transcription factor 2	Bos taurus	201-205
26722217-5	2016	However, molecular and cellular experiments suggested that reversine treatment enhanced selectively the expression of pluripotent marker gene Oct4 and mesenchymal marker genes CD29, CD44 and CD73, but Sox2 and Nanog were not detected.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	59-68	homeobox protein NANOG	Bos taurus	210-215
22926505-7	2014	Apoptosis in reversine-treated cells was exhibited with PARP cleavage and caspase-3 and caspase-8 activation, but not caspase-9 activation, indicating that caspase-dependent apoptosis mediated by an extrinsic pathway took place in reversine-treated cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	13-22	poly(ADP-ribose) polymerase 1	Homo sapiens	56-60
22926505-7	2014	Apoptosis in reversine-treated cells was exhibited with PARP cleavage and caspase-3 and caspase-8 activation, but not caspase-9 activation, indicating that caspase-dependent apoptosis mediated by an extrinsic pathway took place in reversine-treated cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	13-22	caspase 3	Homo sapiens	74-83
22926505-7	2014	Apoptosis in reversine-treated cells was exhibited with PARP cleavage and caspase-3 and caspase-8 activation, but not caspase-9 activation, indicating that caspase-dependent apoptosis mediated by an extrinsic pathway took place in reversine-treated cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	13-22	caspase 8	Homo sapiens	88-97
24169345-8	2013	The inhibitory effect of reversine on FA turnover accounted for a large part on its capacity to interfere with FAK function on regulating its downstream targets.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	25-34	PTK2 protein tyrosine kinase 2	Mus musculus	111-114
26387481-6	2016	In addition, the assumption was supported by the fact that model efflux inhibitors of Pgp and Mrps such as reversine 205 and MK571 significantly inhibited the efflux of toxicants and increased the toxicity of Cd and BNF in zebrafish embryos.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	107-116	phosphoglycolate phosphatase	Danio rerio	86-89
24151075-5	2013	In the presence of reversine, exogenous C-MAD2 does not localize to unattached kinetochores but is still incorporated into the MCC.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	19-28	mitotic arrest deficient 2 like 1	Homo sapiens	42-46
23475158-8	2013	The inhibition rate of cells in the combination group (10 mumol/L reversine, 10 mmol/L aspirin) increased significantly in comparison to that when the drugs were used alone (P < 0.05); moreover, this combination could synergistically inhibit the proliferation of five cervical cancer cell lines (HeLa, U14, Siha, Caski and C33A).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	66-75	small nucleolar RNA, C/D box 14C	Mus musculus	305-308
22592527-6	2012	Videomicroscopy-based cell fate profiling revealed that, in response to high-dose reversine, TP53 (-/-)  (but not TP53 (+/+) ) cells undergo several consecutive rounds of abortive mitosis, resulting in the generation of hyperpolyploid cells that are prone to succumb to apoptosis upon the activation of mitotic catastrophe.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	82-91	tumor protein p53	Homo sapiens	93-97
22519969-4	2012	Treatment with reversine resulted in a significant increase in the expression of the STRO-1 antigen, a marker of mesenchymal stem/progenitor cells: from 0.6%+-0.5% cells in untreated RAW cells to 19.0%+-8.6% in treated cells, but there was no increase in the expression of SH-2 (CD105), an earlier marker of mesenchymal stem cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	15-24	sperm hammerhead 2	Mus musculus	273-277
22519969-4	2012	Treatment with reversine resulted in a significant increase in the expression of the STRO-1 antigen, a marker of mesenchymal stem/progenitor cells: from 0.6%+-0.5% cells in untreated RAW cells to 19.0%+-8.6% in treated cells, but there was no increase in the expression of SH-2 (CD105), an earlier marker of mesenchymal stem cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	15-24	endoglin	Mus musculus	279-284
22477067-6	2012	Reversine induced apoptosis in PDTC cells with caspase-3 and caspase-8 activation, but not caspase-9.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	caspase 3	Homo sapiens	47-56
22477067-6	2012	Reversine induced apoptosis in PDTC cells with caspase-3 and caspase-8 activation, but not caspase-9.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	caspase 8	Homo sapiens	61-70
22592527-1	2012	Reversine is a small synthetic molecule that inhibits multiple mitotic kinases, including MPS1 as well as Aurora kinase A and B (AURKA and AURKB).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	TTK protein kinase	Homo sapiens	90-94
22592527-1	2012	Reversine is a small synthetic molecule that inhibits multiple mitotic kinases, including MPS1 as well as Aurora kinase A and B (AURKA and AURKB).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase A	Homo sapiens	106-127
22592527-7	2012	In line with this notion, the depletion of anti-apoptotic proteins of the BCL-2 family sensitized TP53 (-/-)  cells to the toxic effects of high-dose reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	150-159	BCL2 apoptosis regulator	Homo sapiens	74-79
22592527-1	2012	Reversine is a small synthetic molecule that inhibits multiple mitotic kinases, including MPS1 as well as Aurora kinase A and B (AURKA and AURKB).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase A	Homo sapiens	129-134
22592527-1	2012	Reversine is a small synthetic molecule that inhibits multiple mitotic kinases, including MPS1 as well as Aurora kinase A and B (AURKA and AURKB).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase B	Homo sapiens	139-144
22592527-7	2012	In line with this notion, the depletion of anti-apoptotic proteins of the BCL-2 family sensitized TP53 (-/-)  cells to the toxic effects of high-dose reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	150-159	tumor protein p53	Homo sapiens	98-102
22592527-3	2012	We found that low doses (~0.5 microM) of reversine, which selectively inhibit MPS1 and hence impair the spindle assembly checkpoint, kill human TP53 (-/-)  colon carcinoma cells less efficiently than their wild-type counterparts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	41-50	TTK protein kinase	Homo sapiens	78-82
22592527-9	2012	Altogether, these results suggest that p53-deficient cells are particularly sensitive to the simultaneous inhibition of multiple kinases, including MPS1, as it occurs in response to high-dose reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	192-201	tumor protein p53	Homo sapiens	39-42
22592527-9	2012	Altogether, these results suggest that p53-deficient cells are particularly sensitive to the simultaneous inhibition of multiple kinases, including MPS1, as it occurs in response to high-dose reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	192-201	TTK protein kinase	Homo sapiens	148-152
22592527-3	2012	We found that low doses (~0.5 microM) of reversine, which selectively inhibit MPS1 and hence impair the spindle assembly checkpoint, kill human TP53 (-/-)  colon carcinoma cells less efficiently than their wild-type counterparts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	41-50	tumor protein p53	Homo sapiens	144-148
19947906-8	2010	In chondrogenic media, cells pretreated with reversine exhibited marked increase in the induction of aggrecan, collagen types II, IX, and XI, and versican.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	45-54	versican	Homo sapiens	146-154
22283874-10	2012	In addition, reversine could inhibit Akt/mTORC1 signaling pathway, accounting for its ability to induce autophagy.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	13-22	AKT serine/threonine kinase 1	Homo sapiens	37-40
22283874-10	2012	In addition, reversine could inhibit Akt/mTORC1 signaling pathway, accounting for its ability to induce autophagy.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	13-22	CREB regulated transcription coactivator 1	Mus musculus	41-47
20624901-0	2010	Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	120-129	TTK protein kinase	Homo sapiens	23-27
18974773-2	2009	Reversine is also a potent inhibitor of Aurora B, a protein kinase required for mitotic chromosome segregation, spindle checkpoint function, cytokinesis and histone H3 phosphorylation, raising the possibility that the dedifferentiation capability of reversine is mediated through the inhibition of Aurora B.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase C	Mus musculus	40-48
18974773-2	2009	Reversine is also a potent inhibitor of Aurora B, a protein kinase required for mitotic chromosome segregation, spindle checkpoint function, cytokinesis and histone H3 phosphorylation, raising the possibility that the dedifferentiation capability of reversine is mediated through the inhibition of Aurora B.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase C	Mus musculus	298-306
18974773-2	2009	Reversine is also a potent inhibitor of Aurora B, a protein kinase required for mitotic chromosome segregation, spindle checkpoint function, cytokinesis and histone H3 phosphorylation, raising the possibility that the dedifferentiation capability of reversine is mediated through the inhibition of Aurora B.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	250-259	aurora kinase C	Mus musculus	40-48
18974773-2	2009	Reversine is also a potent inhibitor of Aurora B, a protein kinase required for mitotic chromosome segregation, spindle checkpoint function, cytokinesis and histone H3 phosphorylation, raising the possibility that the dedifferentiation capability of reversine is mediated through the inhibition of Aurora B.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	250-259	aurora kinase C	Mus musculus	298-306
17490611-0	2007	Reversine stimulates adipocyte differentiation and downregulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	thymoma viral proto-oncogene 1	Mus musculus	65-68
17490611-0	2007	Reversine stimulates adipocyte differentiation and downregulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	73-80
17566101-5	2007	Inhibition of MEK1 and nonmuscle myosin II heavy chain results in altered cell cycle and changes in histone acetylation status, but other factors also may contribute to the activity of reversine, including activation of the PI3K signaling pathway.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	185-194	mitogen-activated protein kinase kinase 1	Homo sapiens	14-18
34188712-2	2021	Reversine, a synthetic purine analog, is a multikinase inhibitor that targets aurora kinase A (AURKA) and aurora kinase B (AURKB).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase A	Homo sapiens	78-93
34188712-2	2021	Reversine, a synthetic purine analog, is a multikinase inhibitor that targets aurora kinase A (AURKA) and aurora kinase B (AURKB).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase A	Homo sapiens	95-100
34188712-2	2021	Reversine, a synthetic purine analog, is a multikinase inhibitor that targets aurora kinase A (AURKA) and aurora kinase B (AURKB).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase B	Homo sapiens	106-121
34188712-2	2021	Reversine, a synthetic purine analog, is a multikinase inhibitor that targets aurora kinase A (AURKA) and aurora kinase B (AURKB).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase B	Homo sapiens	123-128
34188712-7	2021	Reversine reduced the viability and clonogenicity in a dose- and/or time-dependent manner in all glioma cells, with HOG (high AURKB-expression) and T98G (high AURKA-expression) cells being more sensitive compared with U251MG cells (low AURKA- and AURKB-expression).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase B	Homo sapiens	126-131
34188712-7	2021	Reversine reduced the viability and clonogenicity in a dose- and/or time-dependent manner in all glioma cells, with HOG (high AURKB-expression) and T98G (high AURKA-expression) cells being more sensitive compared with U251MG cells (low AURKA- and AURKB-expression).	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	aurora kinase A	Homo sapiens	159-164
18483302-3	2008	These effects of reversine are due to the inhibition of Aurora A and B, two related kinases that are implicated in several aspects of mitosis and that are frequently amplified and overexpressed in human tumors.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	17-26	aurora kinase A	Homo sapiens	56-70
33817258-0	2020	Reversine and herbal Xiang-Sha-Liu-Jun-Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-kappaB/caspase signaling pathway.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	118-122
33817258-4	2020	Reversine alleviated the liver index and AST level and improved TAA-induced pathological changes but decreased TAA-induced collagen deposition, and alpha-smooth muscle actin and transforming growth factor-beta1 expression.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	41-44
33817258-4	2020	Reversine alleviated the liver index and AST level and improved TAA-induced pathological changes but decreased TAA-induced collagen deposition, and alpha-smooth muscle actin and transforming growth factor-beta1 expression.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	actin gamma 2, smooth muscle	Rattus norvegicus	148-173
33817258-4	2020	Reversine alleviated the liver index and AST level and improved TAA-induced pathological changes but decreased TAA-induced collagen deposition, and alpha-smooth muscle actin and transforming growth factor-beta1 expression.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	transforming growth factor, beta 1	Rattus norvegicus	178-210
33817258-5	2020	Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1beta, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-kappaB (p65) phosphorylation and caspase 1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	76-80
33817258-5	2020	Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1beta, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-kappaB (p65) phosphorylation and caspase 1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	interleukin 17A	Rattus norvegicus	82-102
33817258-5	2020	Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1beta, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-kappaB (p65) phosphorylation and caspase 1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	interleukin 22	Rattus norvegicus	104-109
33817258-5	2020	Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1beta, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-kappaB (p65) phosphorylation and caspase 1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	interleukin 1 alpha	Rattus norvegicus	111-119
33817258-5	2020	Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1beta, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-kappaB (p65) phosphorylation and caspase 1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	interleukin 6	Rattus norvegicus	121-125
33817258-5	2020	Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1beta, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-kappaB (p65) phosphorylation and caspase 1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	synaptotagmin 1	Rattus norvegicus	278-281
33817258-5	2020	Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1beta, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-kappaB (p65) phosphorylation and caspase 1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	caspase 1	Rattus norvegicus	303-312
33817258-6	2020	Meanwhile, XSLJZD protected TAA-injured liver without increasing fibrosis and enhanced the regulating effect of reversine on RelA, IL-17A, IL-1beta, and MCP-1 cytokines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	112-121	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	125-129
33817258-6	2020	Meanwhile, XSLJZD protected TAA-injured liver without increasing fibrosis and enhanced the regulating effect of reversine on RelA, IL-17A, IL-1beta, and MCP-1 cytokines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	112-121	interleukin 17A	Rattus norvegicus	131-137
33817258-6	2020	Meanwhile, XSLJZD protected TAA-injured liver without increasing fibrosis and enhanced the regulating effect of reversine on RelA, IL-17A, IL-1beta, and MCP-1 cytokines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	112-121	interleukin 1 alpha	Rattus norvegicus	139-147
33817258-6	2020	Meanwhile, XSLJZD protected TAA-injured liver without increasing fibrosis and enhanced the regulating effect of reversine on RelA, IL-17A, IL-1beta, and MCP-1 cytokines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	112-121	mast cell protease 1-like 1	Rattus norvegicus	153-158
34903321-8	2022	Moreover, the inhibition of aurora kinase A by siRNAs and inhibitors (reversine and VX-680) suppressed TPA-induced cell invasion, migration, and EMT in SW480 human colon cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	70-79	aurora kinase A	Homo sapiens	28-43
34306198-0	2021	Reversine inhibits proliferation, invasion and migration and induces cell apoptosis in gastric cancer cells by downregulating TTK.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	TTK protein kinase	Homo sapiens	126-129
34306198-9	2021	Rev-treated cells exhibited reduced matrix metalloproteinase (MMP)2/9 expression and increased apoptosis compared with those in control cells.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-3	matrix metallopeptidase 2	Homo sapiens	36-69
34967265-8	2022	SPRY2, downstream of miR-21-5p, participated in HBC progression with reversine.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	69-78	sprouty RTK signaling antagonist 2	Homo sapiens	0-5
34967265-9	2022	Overall, our study proved that combining the miR-21-5p inhibitor with reversine produced a synergistic effect by regulating SPRY2, thereby limiting HBC progression.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	70-79	sprouty RTK signaling antagonist 2	Homo sapiens	124-129