PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23267165-4	2013	Mesothelin positivity was defined as >2.0 nM, L1CAM as >10 ng/ml, afamin as <45 mg/l and CA125 as >35 U/ml, respectively.	afamin	72-78	mesothelin	Homo sapiens	0-10
28680266-5	2017	The phylogenetic analysis of vertebrate albumin family implied an evolutionary relationship between members of serum albumin, alpha-fetoprotein, vitamin D-binding protein, and afamin.	afamin	176-182	albumin	Homo sapiens	111-124
26902720-4	2016	Wnt3a forms a 1:1 complex with afamin, which remains soluble in aqueous buffer after isolation, and can induce signaling in various cellular systems including the intestical stem cell growth assay.	afamin	31-37	Wnt family member 3A	Homo sapiens	0-5
26902720-5	2016	By co-expressing with afamin, biologically active afamin-Wnt complex can be easily obtained in large quantity.	afamin	22-28	Wnt family member 3	Homo sapiens	57-60
26902720-5	2016	By co-expressing with afamin, biologically active afamin-Wnt complex can be easily obtained in large quantity.	afamin	50-56	Wnt family member 3	Homo sapiens	57-60
26902720-6	2016	As afamin can also solubilize Wnt5a, Wnt3, and many more Wnt subtypes, afamin complexation will open a way to put various Wnt ligands and their signaling mechanisms under a thorough biochemical scrutiny that had been difficult for years.	afamin	3-9	Wnt family member 5A	Homo sapiens	30-35
26902720-6	2016	As afamin can also solubilize Wnt5a, Wnt3, and many more Wnt subtypes, afamin complexation will open a way to put various Wnt ligands and their signaling mechanisms under a thorough biochemical scrutiny that had been difficult for years.	afamin	3-9	Wnt family member 3	Homo sapiens	37-41
26902720-6	2016	As afamin can also solubilize Wnt5a, Wnt3, and many more Wnt subtypes, afamin complexation will open a way to put various Wnt ligands and their signaling mechanisms under a thorough biochemical scrutiny that had been difficult for years.	afamin	3-9	Wnt family member 3	Homo sapiens	30-33
26902720-6	2016	As afamin can also solubilize Wnt5a, Wnt3, and many more Wnt subtypes, afamin complexation will open a way to put various Wnt ligands and their signaling mechanisms under a thorough biochemical scrutiny that had been difficult for years.	afamin	3-9	Wnt family member 3	Homo sapiens	37-40
26902720-6	2016	As afamin can also solubilize Wnt5a, Wnt3, and many more Wnt subtypes, afamin complexation will open a way to put various Wnt ligands and their signaling mechanisms under a thorough biochemical scrutiny that had been difficult for years.	afamin	71-77	Wnt family member 5A	Homo sapiens	30-35
26902720-6	2016	As afamin can also solubilize Wnt5a, Wnt3, and many more Wnt subtypes, afamin complexation will open a way to put various Wnt ligands and their signaling mechanisms under a thorough biochemical scrutiny that had been difficult for years.	afamin	71-77	Wnt family member 3	Homo sapiens	30-33
25208973-0	2014	Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome.	afamin	0-6	insulin	Homo sapiens	48-55
25208973-1	2014	BACKGROUND: High plasma concentrations of the vitamin E-binding protein afamin have been previously shown to be associated with insulin resistance and metabolic syndrome.	afamin	72-78	insulin	Homo sapiens	128-135
25208973-2	2014	We set out to determine whether the concentration of afamin in the serum of women with polycystic ovarian syndrome (PCOS) is elevated in relation to the presence and severity of insulin resistance (IR).	afamin	53-59	insulin	Homo sapiens	178-185
25208973-10	2014	On univariate analyses, afamin serum concentrations significantly correlated with BMI, triglycerides, HOMA Index, and AUC-Insulin.	afamin	24-30	insulin	Homo sapiens	122-129
24928911-8	2014	In patients with PCOS, afamin correlated significantly with homeostatic model assessment-insulin resistance (HOMA-IR), fasting glucose, BMI, FTI, and SHBG (P<0.001), but in a multivariate linear model, only HOMA-IR remained significantly associated with afamin (P=0.001).	afamin	23-29	sex hormone binding globulin	Homo sapiens	150-154
29522788-9	2019	The urinary afamin to creatinine ratio (Afa/Cre) was significantly higher in patients who progressed to a more severe DN stage or had early renal decline than in patients who did not.	afamin	12-18	AFA	Homo sapiens	40-43
17654119-1	2007	We hypothesize that the structure of the heme binding site of paralogous albuminoids alpha-fetoprotein and serum albumin has evolved from the ancestor vitamin D binding protein through the "phylogenetic intermediate" afamin, the most recently discovered albuminoid.	afamin	217-223	alpha fetoprotein	Homo sapiens	85-102
17654119-1	2007	We hypothesize that the structure of the heme binding site of paralogous albuminoids alpha-fetoprotein and serum albumin has evolved from the ancestor vitamin D binding protein through the "phylogenetic intermediate" afamin, the most recently discovered albuminoid.	afamin	217-223	albumin	Homo sapiens	107-120
17654119-1	2007	We hypothesize that the structure of the heme binding site of paralogous albuminoids alpha-fetoprotein and serum albumin has evolved from the ancestor vitamin D binding protein through the "phylogenetic intermediate" afamin, the most recently discovered albuminoid.	afamin	217-223	GC vitamin D binding protein	Homo sapiens	151-176
22749887-0	2012	Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway.	afamin	0-6	thymoma viral proto-oncogene 1	Mus musculus	93-96
22749887-8	2012	Afamin activated Akt in preosteoblasts, and pretreatment with Akt inhibitor significantly blocked afamin-stimulated preosteoblast migration.	afamin	0-6	thymoma viral proto-oncogene 1	Mus musculus	17-20
22749887-8	2012	Afamin activated Akt in preosteoblasts, and pretreatment with Akt inhibitor significantly blocked afamin-stimulated preosteoblast migration.	afamin	98-104	thymoma viral proto-oncogene 1	Mus musculus	62-65
22749887-10	2012	In addition, we identified afamin as one of osteoclast-derived chemokines that affect preosteoblasts through the activation of the Akt-signaling pathway.	afamin	27-33	thymoma viral proto-oncogene 1	Mus musculus	131-134
16489915-2	2006	It is a member of the albuminoid gene superfamily, which consists of AFP, serum albumin, vitamin D binding protein, and alpha-albumin (afamin).	afamin	135-141	afamin	Homo sapiens	120-133
30991357-3	2019	Serum concentrations of afamin are altered in conditions of oxidative stress like insulin resistance (IR) and correlate with the gold standard of IR determination, the HOMA index.	afamin	24-30	insulin	Homo sapiens	82-89
29522788-7	2019	Among them, the levels of afamin, CD44 antigen, and lysosome-associated membrane glycoprotein 2, which have not previously been implicated in DN, were significantly associated with both the urinary albumin to creatinine ratio (ACR) and eGFR.	afamin	26-32	epidermal growth factor receptor	Homo sapiens	236-240
30247793-1	2018	BACKGROUND: Afamin is a plasma vitamin E-binding glycoprotein partially associated with ApoA1-containing high-density lipoprotein (HDL) subfractions.	afamin	12-18	apolipoprotein A1	Homo sapiens	88-93
29587878-2	2018	BACKGROUND: In search of potential early biomarkers for timely prediction of gestational diabetes mellitus (GDM), we focused on afamin, a vitamin E-binding protein in human plasma.. Afamin plays a role in anti-apoptotic cellular processes related to oxidative stress and is associated with insulin resistance and other features of metabolic syndrome.	afamin	128-134	insulin	Homo sapiens	290-297
29587878-2	2018	BACKGROUND: In search of potential early biomarkers for timely prediction of gestational diabetes mellitus (GDM), we focused on afamin, a vitamin E-binding protein in human plasma.. Afamin plays a role in anti-apoptotic cellular processes related to oxidative stress and is associated with insulin resistance and other features of metabolic syndrome.	afamin	182-188	insulin	Homo sapiens	290-297
29441788-8	2018	Because antibody fragments can work as artificial chaperones by stabilizing the structure of proteins and consequently enhance the chance for successful crystallization, we incubated a Fab fragment of the monoclonal anti-afamin antibody N14 with human afamin and obtained a stoichiometric complex.	afamin	221-227	FA complementation group B	Homo sapiens	185-188
29441788-8	2018	Because antibody fragments can work as artificial chaperones by stabilizing the structure of proteins and consequently enhance the chance for successful crystallization, we incubated a Fab fragment of the monoclonal anti-afamin antibody N14 with human afamin and obtained a stoichiometric complex.	afamin	252-258	FA complementation group B	Homo sapiens	185-188
28877915-3	2017	We thus investigated whether afamin concentrations are associated with prediabetes, type 2 diabetes, and insulin resistance (IR).	afamin	29-35	insulin	Homo sapiens	105-112