PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33580518-0	2021	Three Salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2.	salvianolic acid	6-23	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	42-47
35136538-1	2022	Objective: To analyze the clinical observation of salvianolic acid combined with panax notoginseng saponins combined with basic nursing intervention on cerebral ischemia-reperfusion injury in rats and its effects on the expression of apoptosis-related proteins Bcl-2, Bax and caspase-3.	salvianolic acid	50-66	BCL2, apoptosis regulator	Rattus norvegicus	261-266
35136538-1	2022	Objective: To analyze the clinical observation of salvianolic acid combined with panax notoginseng saponins combined with basic nursing intervention on cerebral ischemia-reperfusion injury in rats and its effects on the expression of apoptosis-related proteins Bcl-2, Bax and caspase-3.	salvianolic acid	50-66	BCL2 associated X, apoptosis regulator	Rattus norvegicus	268-271
35136538-1	2022	Objective: To analyze the clinical observation of salvianolic acid combined with panax notoginseng saponins combined with basic nursing intervention on cerebral ischemia-reperfusion injury in rats and its effects on the expression of apoptosis-related proteins Bcl-2, Bax and caspase-3.	salvianolic acid	50-66	caspase 3	Rattus norvegicus	276-285
33580518-0	2021	Three Salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2.	salvianolic acid	6-23	angiotensin converting enzyme 2	Homo sapiens	110-114
33580518-8	2021	In conclusion, our study revealed that three Salvianolic acids can inhibit the entry of 2019-nCoV spike pseudovirus into ACE2h cells by binding to the RBD of the 2019-nCoV spike protein and ACE2 protein.	salvianolic acid	45-62	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	98-103
33580518-8	2021	In conclusion, our study revealed that three Salvianolic acids can inhibit the entry of 2019-nCoV spike pseudovirus into ACE2h cells by binding to the RBD of the 2019-nCoV spike protein and ACE2 protein.	salvianolic acid	45-62	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	172-177
30412748-3	2019	and salvianolic acids from Salvia miltiorhiza Bge., has been found to inhibit hepatocarcinogenesis via mediating transforming growth factor-beta (TGF-beta)/Smad signaling, especially Smad3 phosphorylation.	salvianolic acid	4-21	transforming growth factor beta 1	Homo sapiens	146-154
33580518-8	2021	In conclusion, our study revealed that three Salvianolic acids can inhibit the entry of 2019-nCoV spike pseudovirus into ACE2h cells by binding to the RBD of the 2019-nCoV spike protein and ACE2 protein.	salvianolic acid	45-62	angiotensin converting enzyme 2	Homo sapiens	121-125
32368011-0	2020	Salvianolic Acid Alleviated Blood-Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway.	salvianolic acid	0-16	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	137-140
32368011-0	2020	Salvianolic Acid Alleviated Blood-Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway.	salvianolic acid	0-16	Eph receptor B1	Rattus norvegicus	161-164
31872707-8	2019	There were significant differences in the major pharmacokinetic parameters of Sal B,FA and RA for intravenous infusion of salvianolic acids and Chuanxiong-extract or combined in rat plasma.	salvianolic acid	122-139	glycogen synthase kinase 3 beta	Rattus norvegicus	84-86
33421597-0	2021	Salvianolic Acids for Injection Alleviates Cerebral Ischemia/Reperfusion Injury by Switching M1/M2 Phenotypes and Inhibiting NLRP3 Inflammasome/Pyroptosis Axis in Microglia In Vivo and In Vitro.	salvianolic acid	0-17	NLR family, pyrin domain containing 3	Rattus norvegicus	125-130
29863652-0	2019	Total Salvianolic Acid Injection Prevents Ischemia/Reperfusion-Induced Myocardial Injury Via Antioxidant Mechanism Involving Mitochondrial Respiratory Chain Through the Upregulation of Sirtuin1 and Sirtuin3.	salvianolic acid	6-22	sirtuin 1	Rattus norvegicus	185-193
29863652-0	2019	Total Salvianolic Acid Injection Prevents Ischemia/Reperfusion-Induced Myocardial Injury Via Antioxidant Mechanism Involving Mitochondrial Respiratory Chain Through the Upregulation of Sirtuin1 and Sirtuin3.	salvianolic acid	6-22	sirtuin 3	Rattus norvegicus	198-206
29863652-2	2019	However, whether Total Salvianolic Acid Injection (TSI) protects against myocardial ischemia/reperfusion (I/R) injury through regulating Sirt1, Sirt3, and mitochondrial respiratory chain complexes is unclear.	salvianolic acid	23-39	sirtuin 1	Rattus norvegicus	137-142
29863652-2	2019	However, whether Total Salvianolic Acid Injection (TSI) protects against myocardial ischemia/reperfusion (I/R) injury through regulating Sirt1, Sirt3, and mitochondrial respiratory chain complexes is unclear.	salvianolic acid	23-39	sirtuin 3	Rattus norvegicus	144-149
30412748-3	2019	and salvianolic acids from Salvia miltiorhiza Bge., has been found to inhibit hepatocarcinogenesis via mediating transforming growth factor-beta (TGF-beta)/Smad signaling, especially Smad3 phosphorylation.	salvianolic acid	4-21	SMAD family member 3	Homo sapiens	183-188
30431688-0	2019	Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1-eNOS pathway.	salvianolic acid	0-16	sirtuin 1	Homo sapiens	108-113
30431688-4	2019	SA upregulated the expression levels of Bcl-2 and decreased the levels of Bax, cleaved caspase-3, and cleaved caspase-9.	salvianolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	40-45
30431688-4	2019	SA upregulated the expression levels of Bcl-2 and decreased the levels of Bax, cleaved caspase-3, and cleaved caspase-9.	salvianolic acid	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	74-77
30431688-4	2019	SA upregulated the expression levels of Bcl-2 and decreased the levels of Bax, cleaved caspase-3, and cleaved caspase-9.	salvianolic acid	0-2	caspase 9	Homo sapiens	110-119
30431688-5	2019	Furthermore, the expression levels of Sirtuin 1 (Sirt1) and p-endothelial nitric oxide synthase (eNOS) were markedly increased in response to SA treatment.	salvianolic acid	142-144	sirtuin 1	Homo sapiens	38-47
30431688-5	2019	Furthermore, the expression levels of Sirtuin 1 (Sirt1) and p-endothelial nitric oxide synthase (eNOS) were markedly increased in response to SA treatment.	salvianolic acid	142-144	sirtuin 1	Homo sapiens	49-54
30431688-8	2019	These findings suggest that SA can be used as a potential therapeutic to protect against high glucose-induced endothelial injury by modulating Sirt1-eNOS pathway.	salvianolic acid	28-30	sirtuin 1	Homo sapiens	143-148
30344681-9	2018	The contents of TNF-alpha, IL-6 and PGE2 in Salvianolic Acid-CIA group were obviously lower than those in the model group (P<0.01).	salvianolic acid	44-60	tumor necrosis factor	Rattus norvegicus	16-25
30502765-7	2018	Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC).	salvianolic acid	0-17	stearoyl-CoA desaturase	Homo sapiens	241-246
30502765-8	2018	For the molecular mechanisms, OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription (STAT)-3 was inhibited by salvianolic acids treatment.	salvianolic acid	153-170	signal transducer and activator of transcription 3	Homo sapiens	78-135
30502765-10	2018	Salvianolic acids reduced the upregulation of SREBP1 and TG induced by high glucose in LO2 cells.	salvianolic acid	0-17	sterol regulatory element binding transcription factor 1	Homo sapiens	46-52
30502765-0	2018	Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling.	salvianolic acid	0-17	signal transducer and activator of transcription 3	Rattus norvegicus	85-91
30502765-0	2018	Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling.	salvianolic acid	0-17	sterol regulatory element binding transcription factor 1	Rattus norvegicus	92-98
30502765-7	2018	Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC).	salvianolic acid	0-17	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	133-174
30502765-7	2018	Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC).	salvianolic acid	0-17	sterol regulatory element binding transcription factor 1	Homo sapiens	176-183
30502765-7	2018	Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC).	salvianolic acid	0-17	fatty acid synthase	Homo sapiens	185-204
30502765-7	2018	Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC).	salvianolic acid	0-17	fatty acid synthase	Homo sapiens	206-209
30502765-7	2018	Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC).	salvianolic acid	0-17	stearoyl-CoA desaturase	Homo sapiens	216-239
30344681-9	2018	The contents of TNF-alpha, IL-6 and PGE2 in Salvianolic Acid-CIA group were obviously lower than those in the model group (P<0.01).	salvianolic acid	44-60	interleukin 6	Rattus norvegicus	27-31
30344681-10	2018	The mRNA expression levels of TNF-alpha, IL-6 and PGE2 in the Salvianolic Acid-CIA group were markedly lower than those in the model group.	salvianolic acid	62-78	tumor necrosis factor	Rattus norvegicus	30-39
30344681-10	2018	The mRNA expression levels of TNF-alpha, IL-6 and PGE2 in the Salvianolic Acid-CIA group were markedly lower than those in the model group.	salvianolic acid	62-78	interleukin 6	Rattus norvegicus	41-45
29883664-2	2018	This study aimed to prepare the salvianolic acids and tanshinones dry powder for inhalation (SPI) to achieve pulmonary delivery for the treatment of IPF.	salvianolic acid	32-49	chromogranin A	Homo sapiens	93-96
30142530-0	2018	Activation of Nrf2 signaling by salvianolic acid C attenuates NF-kappaB mediated inflammatory response both in vivo and in vitro.	salvianolic acid	32-48	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
29795391-0	2018	Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.	salvianolic acid	0-17	purinergic receptor P2Y1	Homo sapiens	100-104
30038283-0	2018	Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.	salvianolic acid	19-36	purinergic receptor P2Y1	Homo sapiens	119-123
30038283-0	2018	Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.	salvianolic acid	19-36	purinergic receptor P2Y12	Homo sapiens	128-133
30026682-0	2018	Total Salvianolic Acid Balances Brain Functional Network Topology in Rat Hippocampi Overexpressing miR-30e.	salvianolic acid	6-22	microRNA 30e	Rattus norvegicus	99-106
29795391-0	2018	Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.	salvianolic acid	0-17	purinergic receptor P2Y12	Homo sapiens	109-114
29212498-0	2017	Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome.	salvianolic acid	0-16	NLR family, pyrin domain containing 3	Rattus norvegicus	144-149
29257241-6	2018	In conclusion, the results demonstrated that salvianolic acid B recovers cognitive deficits and angiogenesis in the cerebral small vessel disease rat model via STAT3/VEGF signaling pathway.	salvianolic acid	45-61	signal transducer and activator of transcription 3	Rattus norvegicus	160-165
29257241-6	2018	In conclusion, the results demonstrated that salvianolic acid B recovers cognitive deficits and angiogenesis in the cerebral small vessel disease rat model via STAT3/VEGF signaling pathway.	salvianolic acid	45-61	vascular endothelial growth factor A	Rattus norvegicus	166-170
29382534-0	2018	Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling.	salvianolic acid	0-16	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	69-75
29382534-0	2018	Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling.	salvianolic acid	0-16	mitogen-activated protein kinase 3	Homo sapiens	107-113
29382534-0	2018	Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling.	salvianolic acid	0-16	mitogen-activated protein kinase 1	Homo sapiens	114-117
27915455-6	2017	Interestingly, we also found that the overexpression of AtEDT1 determined the accumulation of salvianolic acids, such as rosmarinic acid, lithospermic acid, salvianolic acid B, and total salvianolic acids due to the induction of the expression levels of salvianolic acid biosynthetic genes.	salvianolic acid	187-204	homeodomain GLABROUS 11	Arabidopsis thaliana	56-62
28887094-0	2017	Salvianolic Acids for Injection (SAFI) promotes functional recovery and neurogenesis via sonic hedgehog pathway after stroke in mice.	salvianolic acid	0-17	sonic hedgehog	Mus musculus	89-103
28771727-0	2017	Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice.	salvianolic acid	0-17	Janus kinase 2	Mus musculus	88-92
28771727-0	2017	Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice.	salvianolic acid	0-17	signal transducer and activator of transcription 3	Mus musculus	93-98
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	50-54	Janus kinase 2	Mus musculus	4-8
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	50-54	signal transducer and activator of transcription 3	Mus musculus	9-14
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	146-150	Janus kinase 2	Mus musculus	4-8
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	146-150	signal transducer and activator of transcription 3	Mus musculus	9-14
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	146-150	Janus kinase 2	Mus musculus	102-106
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	146-150	signal transducer and activator of transcription 3	Mus musculus	107-112
28771727-10	2017	In summary, these data suggest that Sals administration enhances cerebral angiogenesis and promotes neurological recovery after ischemic stroke, mediated by the activation of JAK2/STAT3 signaling pathway.	salvianolic acid	36-40	Janus kinase 2	Mus musculus	175-179
28771727-10	2017	In summary, these data suggest that Sals administration enhances cerebral angiogenesis and promotes neurological recovery after ischemic stroke, mediated by the activation of JAK2/STAT3 signaling pathway.	salvianolic acid	36-40	signal transducer and activator of transcription 3	Mus musculus	180-185
29224910-1	2017	AIMS: To explore the effect of salvianolic acid B (Sal B) on regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis (NASH).	salvianolic acid	31-47	sirtuin 3	Rattus norvegicus	75-80
29224910-1	2017	AIMS: To explore the effect of salvianolic acid B (Sal B) on regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis (NASH).	salvianolic acid	31-47	forkhead box O1	Rattus norvegicus	81-86
27915455-6	2017	Interestingly, we also found that the overexpression of AtEDT1 determined the accumulation of salvianolic acids, such as rosmarinic acid, lithospermic acid, salvianolic acid B, and total salvianolic acids due to the induction of the expression levels of salvianolic acid biosynthetic genes.	salvianolic acid	94-111	homeodomain GLABROUS 11	Arabidopsis thaliana	56-62
29187820-11	2017	In the compatibility of DHI and XI or DGI, salvianolic acids in DHI would be degraded, resulting in the reduction of original composition and generation of new components, and leading to the changes of biological activities.	salvianolic acid	43-60	desmoglein 1	Homo sapiens	38-41
27915455-6	2017	Interestingly, we also found that the overexpression of AtEDT1 determined the accumulation of salvianolic acids, such as rosmarinic acid, lithospermic acid, salvianolic acid B, and total salvianolic acids due to the induction of the expression levels of salvianolic acid biosynthetic genes.	salvianolic acid	94-110	homeodomain GLABROUS 11	Arabidopsis thaliana	56-62
27915455-8	2017	Our results demonstrated that the overexpression of AtEDT1 significantly increased the accumulation of salvianolic acids in S. miltiorrhiza.	salvianolic acid	103-120	homeodomain GLABROUS 11	Arabidopsis thaliana	52-58
28251987-9	2017	In conclusion, Salvianolic acid B maintains the mitochondrial structure stabilization and functional integrity by up-regulating mortalin, which may be associated with increased mitofusin factor Mfn1 and reduced mitofission factor hFis1.	salvianolic acid	15-31	mitofusin 1	Homo sapiens	194-198
28251987-9	2017	In conclusion, Salvianolic acid B maintains the mitochondrial structure stabilization and functional integrity by up-regulating mortalin, which may be associated with increased mitofusin factor Mfn1 and reduced mitofission factor hFis1.	salvianolic acid	15-31	fission, mitochondrial 1	Homo sapiens	230-235
28920383-1	2016	This paper was aimed to investigate the microRNA associated with multidrug resistance gene MDR1 of salvianolic acid A reversal in lung cance.	salvianolic acid	99-115	ATP binding cassette subfamily B member 1	Homo sapiens	91-95
28713492-9	2017	The meta-analysis of six studies showed significant effects of salvianolic acid on increasing VEGF expression compared with the control group (P < 0.01).	salvianolic acid	63-79	vascular endothelial growth factor A	Homo sapiens	94-98
29908115-0	2016	[Salvianolic acid A alleviate the brain damage in rats after cerebral ischemia-reperfusion through Nrf2/HO-1 pathway].	salvianolic acid	1-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	99-103
29908115-0	2016	[Salvianolic acid A alleviate the brain damage in rats after cerebral ischemia-reperfusion through Nrf2/HO-1 pathway].	salvianolic acid	1-17	heme oxygenase 1	Rattus norvegicus	104-108
28920383-10	2016	So the author considered that salvianolic acid A down lung cancer multidrug resistance gene MDR1 is likely to be affected by the miRNA expression and regulation of target genes, to further clarify the traditional Chinese medicine to reverse multi-drug resistant mechanism provides the experimental basis.	salvianolic acid	30-46	ATP binding cassette subfamily B member 1	Homo sapiens	92-96
28875648-1	2016	Salvianolic acid A (SAA), one of the major active water-soluble salvianolic acids of traditional Chinese medicine Salvia miltiorrhiza Bunge, has been reported to be effective on anti-myocardial ischemia, anti-oxidation and anti-thrombus.	salvianolic acid	64-81	serum amyloid A1	Canis lupus familiaris	20-23
27485523-7	2016	In addition, the amount of salvianolic acids and tanshinones was significantly elevated in AtDREB1A transgenic S. miltiorrhiza roots, and most of the genes in the related biosynthetic pathways were up-regulated.	salvianolic acid	27-44	dehydration response element B1A	Arabidopsis thaliana	91-99
27455249-9	2016	Interestingly, co-administering an inhibitor of the PI3K/AKT pathway blunted the effects of SA.	salvianolic acid	92-94	AKT serine/threonine kinase 1	Homo sapiens	57-60
27455249-10	2016	SA represents a potential treatment option for cerebral infarction by up-regulating mtCx43 through the PI3K/AKT pathway.	salvianolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	108-111
27303297-0	2016	Salvianolic Acid B Restored Impaired Barrier Function via Downregulation of MLCK by microRNA-1 in Rat Colitis Model.	salvianolic acid	0-16	myosin light chain kinase 3	Rattus norvegicus	76-80
27303297-0	2016	Salvianolic Acid B Restored Impaired Barrier Function via Downregulation of MLCK by microRNA-1 in Rat Colitis Model.	salvianolic acid	0-16	microRNA 1	Rattus norvegicus	84-94
27398138-0	2016	JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention.	salvianolic acid	114-130	mitogen-activated protein kinase 8	Rattus norvegicus	0-3
27398138-0	2016	JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention.	salvianolic acid	114-130	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
25943027-3	2015	Here, the study showed that Sal A had antiapoptotic effects on the TNF-alpha/D-GalN-treated LO2 cells.	salvianolic acid	28-33	tumor necrosis factor	Homo sapiens	67-76
26591687-1	2015	OBJECTIVE: To investigate the effect of salvianolic acid A and C component molecules, which are involved in drug compatibility, on inflammatory cytokine expression that affects human chemokine ligand 5 (CCL5) and chemokine ligand 10 (CXCL10) levels in rats with unilateral ureteral obstruction (UUO).	salvianolic acid	40-56	C-C motif chemokine ligand 5	Homo sapiens	203-207
26591687-1	2015	OBJECTIVE: To investigate the effect of salvianolic acid A and C component molecules, which are involved in drug compatibility, on inflammatory cytokine expression that affects human chemokine ligand 5 (CCL5) and chemokine ligand 10 (CXCL10) levels in rats with unilateral ureteral obstruction (UUO).	salvianolic acid	40-56	C-X-C motif chemokine ligand 10	Homo sapiens	234-240
26591687-9	2015	RESULTS: In the salvianolic acid A and salvianolic acid C treatment groups, serum Cr and urine NAG levels were significantly lower than in the model group (both P < 0.05).	salvianolic acid	16-32	O-GlcNAcase	Rattus norvegicus	95-98
25943027-8	2015	In summary, Sal A attenuates TNF-alpha- and D-GalN-induced both ER stress and mitochondrial-dependent apoptosis by suppression of Bax/Bcl-2 ratio and prevention of calcium release, which support the notion that Sal A could be developed into a novel hepatic protectant.	salvianolic acid	12-17	BCL2 associated X, apoptosis regulator	Homo sapiens	130-133
25943027-8	2015	In summary, Sal A attenuates TNF-alpha- and D-GalN-induced both ER stress and mitochondrial-dependent apoptosis by suppression of Bax/Bcl-2 ratio and prevention of calcium release, which support the notion that Sal A could be developed into a novel hepatic protectant.	salvianolic acid	12-17	BCL2 apoptosis regulator	Homo sapiens	134-139
25943027-3	2015	Here, the study showed that Sal A had antiapoptotic effects on the TNF-alpha/D-GalN-treated LO2 cells.	salvianolic acid	28-33	galanin and GMAP prepropeptide	Homo sapiens	79-83
25943027-7	2015	Furthermore, the decreased levels of Bax/Bcl-2 ratio and calcium release were measured in Sal A-treated cells.	salvianolic acid	90-95	BCL2 associated X, apoptosis regulator	Homo sapiens	37-40
25943027-7	2015	Furthermore, the decreased levels of Bax/Bcl-2 ratio and calcium release were measured in Sal A-treated cells.	salvianolic acid	90-95	BCL2 apoptosis regulator	Homo sapiens	41-46
25943027-8	2015	In summary, Sal A attenuates TNF-alpha- and D-GalN-induced both ER stress and mitochondrial-dependent apoptosis by suppression of Bax/Bcl-2 ratio and prevention of calcium release, which support the notion that Sal A could be developed into a novel hepatic protectant.	salvianolic acid	12-17	tumor necrosis factor	Homo sapiens	29-38
25943027-8	2015	In summary, Sal A attenuates TNF-alpha- and D-GalN-induced both ER stress and mitochondrial-dependent apoptosis by suppression of Bax/Bcl-2 ratio and prevention of calcium release, which support the notion that Sal A could be developed into a novel hepatic protectant.	salvianolic acid	12-17	galanin and GMAP prepropeptide	Homo sapiens	46-50
26176734-0	2015	Salvianolic acid A reverses the paclitaxel resistance and inhibits the migration and invasion abilities of human breast cancer cells by inactivating transgelin 2.	salvianolic acid	0-16	transgelin 2	Homo sapiens	149-161
25956064-0	2015	Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-gamma and LXRalpha.	salvianolic acid	0-16	ATP binding cassette subfamily A member 1	Homo sapiens	31-36
25956064-0	2015	Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-gamma and LXRalpha.	salvianolic acid	0-16	peroxisome proliferator activated receptor gamma	Homo sapiens	79-89
25956064-0	2015	Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-gamma and LXRalpha.	salvianolic acid	0-16	nuclear receptor subfamily 1 group H member 3	Homo sapiens	94-102
25555594-0	2015	Effective dose of the combination of salvianolic acids and tanshinones against inflammatory injury in human umbilical vein endothelial cells injured by thrombin.	salvianolic acid	37-54	coagulation factor II, thrombin	Homo sapiens	152-160
25555594-2	2015	METHODS: Thrombin (50 U/mL) was incubated in human umbilical vein endothelia cells (HUVECs) with 50 and 100 mug/L (1:0, 0:1, 3:1, 2:1, 1:1, and 1:2) salvianolic acids and tanshinones or without the components of Danshen extract.	salvianolic acid	149-166	coagulation factor II, thrombin	Homo sapiens	9-17
21117944-4	2011	Praeruptorin A and C, salvianolic acid B, sodium danshensu, protocatechuic aldehyde, cryptotanshinone, emodin, morin, and tanshinone IIA significantly transactivated the CYP3A4 reporter gene construct in either HepG2 or Huh7 cells.	salvianolic acid	22-38	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	170-176
24702968-0	2014	Role of NADPH oxidase in total salvianolic acid injection attenuating ischemia-reperfusion impaired cerebral microcirculation and neurons: implication of AMPK/Akt/PKC.	salvianolic acid	31-47	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
24702968-0	2014	Role of NADPH oxidase in total salvianolic acid injection attenuating ischemia-reperfusion impaired cerebral microcirculation and neurons: implication of AMPK/Akt/PKC.	salvianolic acid	31-47	protein kinase C, gamma	Rattus norvegicus	163-166
24462865-0	2014	Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1.	salvianolic acid	0-16	angiotensinogen	Rattus norvegicus	48-62
24462865-0	2014	Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1.	salvianolic acid	0-16	poly (ADP-ribose) polymerase 1	Rattus norvegicus	101-107
24816457-0	2014	Salvianolic acid B maintained stem cell pluripotency and increased proliferation rate by activating Jak2-Stat3 combined with EGFR-Erk1/2 pathways.	salvianolic acid	0-16	Janus kinase 2	Homo sapiens	100-104
24816457-0	2014	Salvianolic acid B maintained stem cell pluripotency and increased proliferation rate by activating Jak2-Stat3 combined with EGFR-Erk1/2 pathways.	salvianolic acid	0-16	signal transducer and activator of transcription 3	Homo sapiens	105-110
24816457-0	2014	Salvianolic acid B maintained stem cell pluripotency and increased proliferation rate by activating Jak2-Stat3 combined with EGFR-Erk1/2 pathways.	salvianolic acid	0-16	epidermal growth factor receptor	Homo sapiens	125-129
24816457-0	2014	Salvianolic acid B maintained stem cell pluripotency and increased proliferation rate by activating Jak2-Stat3 combined with EGFR-Erk1/2 pathways.	salvianolic acid	0-16	mitogen-activated protein kinase 3	Homo sapiens	130-136
23201927-0	2013	Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway.	salvianolic acid	27-43	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
22986787-0	2012	Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway.	salvianolic acid	0-16	ras homolog family member A	Rattus norvegicus	131-135
24769256-0	2014	Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.	salvianolic acid	0-16	sirtuin 1	Rattus norvegicus	79-84
24769256-0	2014	Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.	salvianolic acid	0-16	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	111-114
23725837-7	2013	RESULTS: Salvianolic acid at 0.4, 0.8 mg L(-1), the same as notoginseng triterpenes, increased VEGF content in EA-hy926 cells.	salvianolic acid	9-25	vascular endothelial growth factor A	Homo sapiens	95-99
23725837-8	2013	Expression of VEGF protein in the salvianolic acid at 1.2 mg L(-1) group, was up-regulated as compared with notoginseng triterpenes group (P < 0.05).	salvianolic acid	34-50	vascular endothelial growth factor A	Homo sapiens	14-18
23725837-9	2013	CONCLUSION: Salvianolic acid and notoginseng triterpenes can promote EA-hy926 cell proliferation, angiogenesis and expression of VEGF protein.	salvianolic acid	12-28	vascular endothelial growth factor A	Homo sapiens	129-133
20882408-8	2011	Salvianolic acid A reduced the content of malondialdehyde and increased the activities of superoxide dismutase, catalase and glutathione peroxidase in hippocampus.	salvianolic acid	0-16	catalase	Mus musculus	112-120
20349720-1	2010	OBJECTIVE: To investigate the mechanism of salvianolic acid B (Sal B) action against liver fibrosis through preventing lipid peroxidation and regulating MMP-2 activity in liver.	salvianolic acid	43-59	matrix metallopeptidase 2	Rattus norvegicus	153-158
12425809-0	2002	Effects of salvianolic acid-B on TGF-beta 1 stimulated hepatic stellate cell activation and its intracellular signaling.	salvianolic acid	11-27	transforming growth factor, beta 1	Rattus norvegicus	33-43
19431100-0	2009	Cardioprotection and matrix metalloproteinase-9 regulation of salvianolic acids on myocardial infarction in rats.	salvianolic acid	62-79	matrix metallopeptidase 9	Rattus norvegicus	21-47
19431100-6	2009	Furthermore, treatment with SA significantly downregulated the mRNA expression level and activity of matrix metalloproteinase-9 (MMP-9), but did not regulate the tissue inhibitor of metalloproteinase-1 (TIMP-1) expression level at the infarct area.	salvianolic acid	28-30	matrix metallopeptidase 9	Rattus norvegicus	101-127
19431100-6	2009	Furthermore, treatment with SA significantly downregulated the mRNA expression level and activity of matrix metalloproteinase-9 (MMP-9), but did not regulate the tissue inhibitor of metalloproteinase-1 (TIMP-1) expression level at the infarct area.	salvianolic acid	28-30	matrix metallopeptidase 9	Rattus norvegicus	129-134
18457363-7	2008	550 mg/kg/day SA or NG for 5 days could significantly inhibit ADP-induced platelet aggregation of PRP.	salvianolic acid	14-16	proline rich protein 2-like 1	Rattus norvegicus	98-101
18457363-8	2008	Moreover, combination of SA and NG at a ratio of 5:1 had a synergistic effect on platelet aggregation of PRP.	salvianolic acid	25-27	proline rich protein 2-like 1	Rattus norvegicus	105-108
17244260-5	2007	In addition, salvianolic acid A treatment remarkably reduced intrahepatic tumour necrosis factor-alpha concentrations and caspase-3 activities as compared with the CCl(4)-treated rats.	salvianolic acid	13-29	caspase 3	Rattus norvegicus	122-131
15706878-3	2004	RESULT: Water-soluble fractions, total salvianolic acids and salvianolic acid B markedly decreased ACE activity of rabbit lung tissue.	salvianolic acid	39-56	angiotensin-converting enzyme	Oryctolagus cuniculus	99-102
12222659-1	2002	This study was conducted to observe the effect of salvianolic acids (SA) on regional cerebral blood flow (rCBF) in rats and on platelet aggregation in vitro and in vivo.	salvianolic acid	50-67	CCAAT/enhancer binding protein zeta	Rattus norvegicus	106-110
12222659-1	2002	This study was conducted to observe the effect of salvianolic acids (SA) on regional cerebral blood flow (rCBF) in rats and on platelet aggregation in vitro and in vivo.	salvianolic acid	69-71	CCAAT/enhancer binding protein zeta	Rattus norvegicus	106-110
12222659-12	2002	The results suggest that SA could improve rCBF in the ischemic hemisphere and inhibit platelet aggregation in rats.	salvianolic acid	25-27	CCAAT/enhancer binding protein zeta	Rattus norvegicus	42-46