PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33596023-0 2021 Identification of HLA-A*0201-restricted CTL Epitopes for MLAA-34-specific Immunotherapy for Acute Monocytic Leukemia. mlaa 57-61 major histocompatibility complex, class I, A Homo sapiens 18-23 18592235-6 2009 Thus, we propose that MLAA-34 is a novel CAB39L"s splice variant associated with acute monocytic leukemia. mlaa 22-26 calcium binding protein 39 like Homo sapiens 41-47 14710187-0 2004 MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes. mlaa 0-4 MRE11 homolog, double strand break repair nuclease Homo sapiens 39-44 14710187-1 2004 We identify and characterize MlaA, a novel protein, which is found in a conserved operon with Mre11 and Rad50 in archaeal genomes. mlaa 29-33 MRE11 homolog, double strand break repair nuclease Homo sapiens 94-99 14710187-1 2004 We identify and characterize MlaA, a novel protein, which is found in a conserved operon with Mre11 and Rad50 in archaeal genomes. mlaa 29-33 RAD50 double strand break repair protein Homo sapiens 104-109 14710187-2 2004 MlaA is fused with Mre11 in Methanobacter thermoautotrophicus, suggesting the MlaA is functionally linked to the Mre11 complex. mlaa 0-4 MRE11 homolog, double strand break repair nuclease Homo sapiens 113-118 14710187-2 2004 MlaA is fused with Mre11 in Methanobacter thermoautotrophicus, suggesting the MlaA is functionally linked to the Mre11 complex. mlaa 78-82 MRE11 homolog, double strand break repair nuclease Homo sapiens 19-24 14710187-2 2004 MlaA is fused with Mre11 in Methanobacter thermoautotrophicus, suggesting the MlaA is functionally linked to the Mre11 complex. mlaa 78-82 MRE11 homolog, double strand break repair nuclease Homo sapiens 113-118 33596023-2 2021 Here, we sought to identify HLA-A*0201-restricted cytotoxic T-lymphocyte (CTL) epitope of MLAA-34 by reverse immunology. mlaa 90-94 major histocompatibility complex, class I, A Homo sapiens 28-33 33596023-3 2021 In all, 10 HLA-A*0201 restricted epitopes of MLAA-34 were predicted by bioinformatics. mlaa 45-49 major histocompatibility complex, class I, A Homo sapiens 11-16 33596023-4 2021 MLAA-34324-332, MLAA-34293-301, and MLAA-34236-244 showed the strongest HLA-A*0201-binding affinity. mlaa 0-4 major histocompatibility complex, class I, A Homo sapiens 72-77 33596023-7 2021 MLAA-34236-244-induced CTLs presented a stronger cytotoxic effect on THP-1 cells (HLA-A*0201+MLAA-34+) at various effector to target ratios. mlaa 0-4 major histocompatibility complex, class I, A Homo sapiens 82-87 33596023-14 2021 MLAA-34236-244 peptide (ILDRHNFAI) is an effective HLA-A*0201-restricted CTL epitope and that it may serve as a promising strategy in designing antigen-specific immunotherapy against MLAA-34-positive acute monocytic leukemia. mlaa 0-4 major histocompatibility complex, class I, A Homo sapiens 51-56 27910823-0 2016 Optimized MLAA for quantitative non-TOF PET/MR of the brain. mlaa 10-14 FEZ family zinc finger 2 Homo sapiens 36-39 33123268-0 2020 MLAA-34 knockdown shows enhanced antitumor activity via JAK2/STAT3 signaling pathway in acute monocytic leukemia. mlaa 0-4 Janus kinase 2 Homo sapiens 56-60 33123268-0 2020 MLAA-34 knockdown shows enhanced antitumor activity via JAK2/STAT3 signaling pathway in acute monocytic leukemia. mlaa 0-4 signal transducer and activator of transcription 3 Homo sapiens 61-66 33123268-4 2020 However, the relationship and interaction between MLAA-34 and JAK2/STAT3 has never been investigated in AML. mlaa 50-54 Janus kinase 2 Homo sapiens 62-66 33123268-4 2020 However, the relationship and interaction between MLAA-34 and JAK2/STAT3 has never been investigated in AML. mlaa 50-54 signal transducer and activator of transcription 3 Homo sapiens 67-72 33123268-5 2020 This study investigates and reports a novel relationship between MLAA-34 and JAK2/STAT3 pathway in AML both in vitro and in vivo. mlaa 65-69 Janus kinase 2 Homo sapiens 77-81 33123268-5 2020 This study investigates and reports a novel relationship between MLAA-34 and JAK2/STAT3 pathway in AML both in vitro and in vivo. mlaa 65-69 signal transducer and activator of transcription 3 Homo sapiens 82-87 33123268-6 2020 We constructed MLAA-34 knockdown vector and transfected U937 cells to observe its apoptotic activities in relation to JAK2/STAT3 signaling pathway in vitro and then in vivo in mouse model. mlaa 15-19 Janus kinase 2 Homo sapiens 118-122 33123268-6 2020 We constructed MLAA-34 knockdown vector and transfected U937 cells to observe its apoptotic activities in relation to JAK2/STAT3 signaling pathway in vitro and then in vivo in mouse model. mlaa 15-19 signal transducer and activator of transcription 3 Homo sapiens 123-128 33123268-13 2020 Correlation of MLAA-34 and JAK2/STAT3 was further confirmed in AML patients. mlaa 15-19 Janus kinase 2 Homo sapiens 27-31 33123268-13 2020 Correlation of MLAA-34 and JAK2/STAT3 was further confirmed in AML patients. mlaa 15-19 signal transducer and activator of transcription 3 Homo sapiens 32-37 33123268-15 2020 Thus we report a novel model of interaction mechanism between MLAA-34 and JAK2/STAT3 which can be utilized as a potential target for a novel therapeutic approach in AML. mlaa 62-66 Janus kinase 2 Homo sapiens 74-78 33123268-15 2020 Thus we report a novel model of interaction mechanism between MLAA-34 and JAK2/STAT3 which can be utilized as a potential target for a novel therapeutic approach in AML. mlaa 62-66 signal transducer and activator of transcription 3 Homo sapiens 79-84 31607299-6 2019 EMSA and ChIP experiments demonstrated that MZF-1 could directly bind to MLAA-34 promoter and play a regulatory role. mlaa 73-77 myeloid zinc finger 1 Homo sapiens 44-49 31607299-7 2019 In the over-expression test, the increase of MZF-1 could up-regulate the expression of MLAA-34 (P<0.05). mlaa 87-91 myeloid zinc finger 1 Homo sapiens 45-50 29059232-8 2017 In addition, MLAA-34 overexpression significantly increased the expression of nuclear beta-catenin protein in ATO-treated cells compared with HeLa cells treated only with ATO. mlaa 13-17 catenin beta 1 Homo sapiens 86-98 27910823-6 2016 In this study, a reconstruction technique based on a modified and optimized non-TOF MLAA is proposed for PET/MR brain imaging. mlaa 84-88 FEZ family zinc finger 2 Homo sapiens 80-83 27910823-9 2016 Because the non-TOF MLAA is used, a technique to reduce the cross-talk effect is proposed. mlaa 20-24 FEZ family zinc finger 2 Homo sapiens 16-19 26807175-8 2015 There were significant differences in the expression levels of beta-Catenin and TCF 4 between U937 cells and U937 with MLAA-34-siRNA cells group. mlaa 119-123 catenin beta 1 Homo sapiens 63-75