PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16936200-4	2006	We demonstrate that the circulating form of halofenate, halofenic acid (HA), binds to and selectively modulates PPAR-gamma.	ha	72-74	peroxisome proliferator activated receptor gamma	Homo sapiens	112-122
20237495-7	2010	Furthermore, death ligand and diclofenac/HA-mediated apoptosis were blocked by the same caspase inhibitors, indicating related pathways.	ha	41-43	caspase 8	Homo sapiens	88-95
18501404-7	2008	The competitive effects of these ions on As(V) removal were in the order of PO(4)(3-), SiO(3)(2-), HA, HCO(3)(-), and Cl(-).	ha	99-101	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
12949055-8	2003	OPN increased HepG2 in vitro adhesion to hyaluronate (HA); excess soluble HA extinguished OPN-mediated HepG2 adhesion, indicating CD44 dependence.	ha	54-56	secreted phosphoprotein 1	Homo sapiens	0-3
15147796-2	2004	In order to identify the components responsible for this effect we investigated the potency of food derived genotoxic heterocyclic aromatic amines (HA) to induce CYP1A1 in vitro.	ha	148-150	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	162-168
10529137-1	1999	OBJECTIVE: To investigate the effects of hyaluronate (HA) on CD44 expression of infiltrating cells in vivo.	ha	54-56	CD44 molecule (Indian blood group)	Rattus norvegicus	61-65
12124794-2	2002	This study describes a novel basic fibroblast growth factor-2 (FGF-2) delivery system synthesized by the conjugation of a structure-stabilizing polymer, hyaluronate (HA), with a sulfated glycosaminoglycan, heparin (HP), that has inherent specific binding sites for members of the FGF family.	ha	166-168	fibroblast growth factor 2	Homo sapiens	35-61
12124794-2	2002	This study describes a novel basic fibroblast growth factor-2 (FGF-2) delivery system synthesized by the conjugation of a structure-stabilizing polymer, hyaluronate (HA), with a sulfated glycosaminoglycan, heparin (HP), that has inherent specific binding sites for members of the FGF family.	ha	166-168	fibroblast growth factor 2	Homo sapiens	63-68
12124794-2	2002	This study describes a novel basic fibroblast growth factor-2 (FGF-2) delivery system synthesized by the conjugation of a structure-stabilizing polymer, hyaluronate (HA), with a sulfated glycosaminoglycan, heparin (HP), that has inherent specific binding sites for members of the FGF family.	ha	166-168	fibroblast growth factor 2	Homo sapiens	63-66
11737075-2	2001	Furthermore, alveolar macrophages could produce IL-8 subsequent to CD44-hyaluronic acid (HA) interaction.	ha	89-91	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
11737075-2	2001	Furthermore, alveolar macrophages could produce IL-8 subsequent to CD44-hyaluronic acid (HA) interaction.	ha	89-91	CD44 molecule (Indian blood group)	Homo sapiens	67-71
10617906-6	2000	RESULTS: The concentration of HA in conditioned medium of HTF was significantly increased only after stimulation with PDGF-AA [10 and 100ng/ml], IL-1beta [1 and 10ng/ml] and TGF-beta1 [5ng/ml].	ha	30-32	interleukin 1 beta	Homo sapiens	145-153
10617906-6	2000	RESULTS: The concentration of HA in conditioned medium of HTF was significantly increased only after stimulation with PDGF-AA [10 and 100ng/ml], IL-1beta [1 and 10ng/ml] and TGF-beta1 [5ng/ml].	ha	30-32	transforming growth factor beta 1	Homo sapiens	174-183
11463496-4	2001	Hyaluronate (HA), a ligand of CD44, inhibited a number of lung metastases in a dose-dependent manner (0.5% HA, 3.0+/-1.1; 0.005% HA, 5.1+/-1.5; without HA, 8.6+/-1.7; N=10 for each; P<0.05, each group with HA versus the group without HA).	ha	13-15	CD44 antigen	Mus musculus	30-34
11316791-3	2001	At high cell density, merlin becomes hypo-phosphorylated and inhibits cell growth in response to hyaluronate (HA), a mucopolysaccharide that surrounds cells.	ha	110-112	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	22-28
7515923-3	1994	Here, we show that hyaluronate (HA), a CD44 ligand, in conjunction with CD3/TCR-mediated stimuli, is costimulatory for human peripheral blood T cell proliferation, for IL-2 production by Th clones, and for release of trypsin-like esterase by cytolytic T cell clones.	ha	32-34	CD44 molecule (Indian blood group)	Homo sapiens	39-43
9739051-2	1998	CD44 on lymphocytes that has been "activated" to bind its principal ligand hyaluronate (HA) on endothelium can mediate the primary adhesion (rolling) of lymphocytes to vascular endothelial cells under conditions of physiologic shear stress, and this interaction is used for activated T cell extravasation into an inflamed site in vivo in mice (DeGrendele, H.C., P. Estess, L.J.	ha	88-90	CD44 antigen	Mus musculus	0-4
9634539-4	1998	This structural arrangement, which occurs within either the invariant region or the extracellular domain of the variant region, is important for CD44-mediated communication between extracellular matrix materials [ECM-hyaluronic acid (HA), collagen and fibronectin] and intracellular protein components (e.g cytoskeletal proteins and various regulatory enzymes).	ha	234-236	CD44 molecule (Indian blood group)	Homo sapiens	145-149
8680787-3	1996	OBJECTIVE: We sought to determine whether topical application of recombinant tissue plasminogen activator (tPA) compounded in 1% hyaluronate acid (HA) can be used safely in venous ulcers and whether it can accelerate healing.	ha	147-149	chromosome 20 open reading frame 181	Homo sapiens	77-105
7528778-2	1995	The principal known ligand for CD44 is the glycosaminoglycan hyaluronate, (HA), a major constituent of extracellular matrices.	ha	75-77	CD44 molecule (Indian blood group)	Homo sapiens	31-35
10199742-2	1999	METHODS: Because administration of the principal ligand of CD44, hyaluronate (HA), in soluble form, can inhibit CD44-HA interaction, we tested the effects of HA in vivo in an established model of chronic allograft rejection.	ha	78-80	CD44 molecule (Indian blood group)	Homo sapiens	59-63
10199742-2	1999	METHODS: Because administration of the principal ligand of CD44, hyaluronate (HA), in soluble form, can inhibit CD44-HA interaction, we tested the effects of HA in vivo in an established model of chronic allograft rejection.	ha	78-80	CD44 molecule (Indian blood group)	Homo sapiens	112-116
8674073-2	1996	The CD44 proteins carry amino acid sequence motifs that confer the ability to bind to the extracellular matrix component hyaluronate (HA).	ha	134-136	CD44 molecule (Indian blood group)	Rattus norvegicus	4-8
8093047-6	1994	A putative hyaluronate (HA)-binding motif which has recently been identified in CD44 antigen existed in the extracellular domain and intracellular amino terminus of CD38 antigen.	ha	24-26	CD44 molecule (Indian blood group)	Homo sapiens	80-84
8093047-6	1994	A putative hyaluronate (HA)-binding motif which has recently been identified in CD44 antigen existed in the extracellular domain and intracellular amino terminus of CD38 antigen.	ha	24-26	CD38 molecule	Homo sapiens	165-169
7515923-3	1994	Here, we show that hyaluronate (HA), a CD44 ligand, in conjunction with CD3/TCR-mediated stimuli, is costimulatory for human peripheral blood T cell proliferation, for IL-2 production by Th clones, and for release of trypsin-like esterase by cytolytic T cell clones.	ha	32-34	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	76-79
7515923-3	1994	Here, we show that hyaluronate (HA), a CD44 ligand, in conjunction with CD3/TCR-mediated stimuli, is costimulatory for human peripheral blood T cell proliferation, for IL-2 production by Th clones, and for release of trypsin-like esterase by cytolytic T cell clones.	ha	32-34	interleukin 2	Homo sapiens	168-172
34235861-3	2021	One of the MARGs, HA-(PEG 3 -DNP) 8 , showed the best capacity for clustering anti-DNP antibodies onto CD44-positive cancer cells and displayed potent in vitro anti-cancer activity by triggering complement dependent cytotoxicity (CDC) and antibody dependent cell-mediated cytotoxicity (ADCC).	ha	18-20	paternally expressed 3	Mus musculus	22-27
8472428-1	1993	Hyaluronate (HA) is linear unbranched polysaccharide consisting of repeating disaccharide units of (1-4)-D-glucuronic acid-beta-(1-3)-D-N-acetylglucosamine.	ha	13-15	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	123-132
1914415-1	1991	Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro.	ha	65-67	interleukin 1 alpha	Homo sapiens	0-13
1914415-1	1991	Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro.	ha	65-67	interleukin 1 alpha	Homo sapiens	15-19
1832659-1	1991	Quantitative biosynthetic studies with cultures highly enriched for glial fibrillary acidic protein (GFAP+) cells of neonatal mammalian brain demonstrated production of four proteoglycans: hyaluronate (HA), heparan sulphate (HS), chondroitin sulphate (CS), and dermatan sulphate (DS).	ha	202-204	glial fibrillary acidic protein	Homo sapiens	68-99
34970150-3	2021	We focus on the role of cytotoxic human amylin (hA) aggregates in the pathogenesis of T2DM, and how polyphenols can ameliorate this process by suppressing or modifying their formation.	ha	48-50	islet amyloid polypeptide	Homo sapiens	40-46
34118005-0	2021	Sorption of Se(IV) from aqueous solution by wheat bran-hydroxyapatite (HA) composite.	ha	71-73	squalene epoxidase	Homo sapiens	12-18
34235861-3	2021	One of the MARGs, HA-(PEG 3 -DNP) 8 , showed the best capacity for clustering anti-DNP antibodies onto CD44-positive cancer cells and displayed potent in vitro anti-cancer activity by triggering complement dependent cytotoxicity (CDC) and antibody dependent cell-mediated cytotoxicity (ADCC).	ha	18-20	CD44 antigen	Mus musculus	103-107
34421636-6	2021	R MAX to potassium, NA, and PHE were lower in HA-NBSH when compared with LA-NBSH and potency results were similar.	ha	46-48	protein max	Ovis aries	2-5
35379124-2	2022	OBJECTIVE: To explore the hub genes and potential mechanisms of HA and NA PCOS through bioinformatics analysis.	ha	64-66	ELAV like RNA binding protein 2	Homo sapiens	26-29
32944844-5	2020	METHODS: In the present study, we used the carboxylated graphene oxide (CGO) conjugated with trimethyl chitosan (TMC) and hyaluronate (HA) nanoparticles (NPs) loaded with HIF-1alpha-siRNA and Dinaciclib, the CDK inhibitor, for silencing HIF-1alpha and blockade of CDKs in CD44-expressing cancer cells and evaluated the impact of combination therapy on proliferation, metastasis, apoptosis, and tumor growth.	ha	135-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
32969286-6	2021	The liver-specific functions, such as urea and albumin synthesis, and CYP1A2 and CYP3A4 activities from encapsulated cells were increased in the HA-SA-CS microcapsules compared to the SA-CS microcapsules.	ha	145-147	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
32969286-6	2021	The liver-specific functions, such as urea and albumin synthesis, and CYP1A2 and CYP3A4 activities from encapsulated cells were increased in the HA-SA-CS microcapsules compared to the SA-CS microcapsules.	ha	145-147	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
33609543-1	2021	The present study aimed to investigate the invitro preconditioning of adipose-derived mesenchymal stem cells (ADMSCs) with CD44-targeted hyalournic acid (HA) on ischemic kidney injury in rats.	ha	154-156	CD44 molecule (Indian blood group)	Rattus norvegicus	123-127
33187133-3	2020	These dots thus prepared ( 10 nm in diameter) enabled extensive cellular interactions such as hyaluronate (HA)-mediated CD44 receptor binding, ALN-mediated bone targeting, and cRGD-mediated tumor integrin alphavbeta3 binding, thus improving their tumor targeting efficiency, especially for metastasized MDA-MB-231 tumors.	ha	107-109	CD44 molecule (Indian blood group)	Homo sapiens	120-124
35422895-7	2022	We then established a cellular model of oxygen glucose deprivation (OGD) in vitro, and knockdown of FUNDC1 attenuated the protective effect of HA exposed on cardiomyocyte mitochondria and increased cardiomyocyte apoptosis.	ha	143-145	FUN14 domain containing 1	Mus musculus	100-106
33663157-4	2021	Poly lactic-co-glycolic acid (PLGA)-Wnt3a-hyaluronic acid (HA) hydrogel was injected locally into the gingival sulcus of mice with experimental periodontitis.	ha	59-61	wingless-type MMTV integration site family, member 3A	Mus musculus	36-41
32944844-5	2020	METHODS: In the present study, we used the carboxylated graphene oxide (CGO) conjugated with trimethyl chitosan (TMC) and hyaluronate (HA) nanoparticles (NPs) loaded with HIF-1alpha-siRNA and Dinaciclib, the CDK inhibitor, for silencing HIF-1alpha and blockade of CDKs in CD44-expressing cancer cells and evaluated the impact of combination therapy on proliferation, metastasis, apoptosis, and tumor growth.	ha	135-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	237-247
32944844-5	2020	METHODS: In the present study, we used the carboxylated graphene oxide (CGO) conjugated with trimethyl chitosan (TMC) and hyaluronate (HA) nanoparticles (NPs) loaded with HIF-1alpha-siRNA and Dinaciclib, the CDK inhibitor, for silencing HIF-1alpha and blockade of CDKs in CD44-expressing cancer cells and evaluated the impact of combination therapy on proliferation, metastasis, apoptosis, and tumor growth.	ha	135-137	cyclin dependent kinase 1	Homo sapiens	264-268
32944844-5	2020	METHODS: In the present study, we used the carboxylated graphene oxide (CGO) conjugated with trimethyl chitosan (TMC) and hyaluronate (HA) nanoparticles (NPs) loaded with HIF-1alpha-siRNA and Dinaciclib, the CDK inhibitor, for silencing HIF-1alpha and blockade of CDKs in CD44-expressing cancer cells and evaluated the impact of combination therapy on proliferation, metastasis, apoptosis, and tumor growth.	ha	135-137	CD44 molecule (Indian blood group)	Homo sapiens	272-276
29679806-4	2018	Next, hyaluronic (HA) was coated on the surface of the mpg-C3N4 via an amide linkage to construct the tumor-targeting HAase/CAT dual activatable and mpg-C3N4/HMME response photosensitizer delivery system (HA@mpg-C3N4-HMME/CAT).	ha	18-20	catalase	Homo sapiens	124-127
32544101-3	2020	In mice with hHER2-high livers, both the high-affinity (HA) and low-affinity (LA) CARTs caused lethal liver damage due to immunotoxicity.	ha	56-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-18
32563474-10	2020	Humid acid (HA) could slightly promote the absorption of CIP by SMD2.	ha	12-14	small nuclear ribonucleoprotein D2 polypeptide	Homo sapiens	64-68
32681257-4	2020	Our results showed that YGL suppressed CCl4-induced upregulation of collagen IV (Col IV), type HI precollagen (PCHI), hyaluronuc acid (HA) and laminin (LN), which are implicated in liver fibrosis.	ha	135-137	C-C motif chemokine ligand 4	Rattus norvegicus	39-43
29679806-4	2018	Next, hyaluronic (HA) was coated on the surface of the mpg-C3N4 via an amide linkage to construct the tumor-targeting HAase/CAT dual activatable and mpg-C3N4/HMME response photosensitizer delivery system (HA@mpg-C3N4-HMME/CAT).	ha	18-20	catalase	Homo sapiens	222-225
27775884-3	2016	Here, to improve the transdermal delivery efficiency, EGF was conjugated to hyaluronate (HA), which was formulated into a patch-type film for skin wound healing.	ha	89-91	epidermal growth factor	Homo sapiens	54-57
29616250-2	2018	Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells.	ha	67-69	epidermal growth factor	Homo sapiens	6-29
29616250-2	2018	Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells.	ha	67-69	epidermal growth factor	Homo sapiens	31-34
28597662-1	2017	Chitosan/hyaluronic acid (HA) nanoparticles can be used to deliver an RNA/DNA cargo to cells overexpressing HA receptors such as CD44.	ha	26-28	CD44 molecule	Canis lupus familiaris	129-133
23932502-2	2013	In this work, dexamethasone (Dexa) was loaded in Flt1 peptide-hyaluronic acid (HA) conjugate nanoparticles to overcome the limitation of corticosteroid resistance for the treatment of neutrophilic pulmonary inflammation.	ha	79-81	FMS-like tyrosine kinase 1	Mus musculus	49-53
26117979-4	2015	CD44 is a cell-surface glycoprotein, which binds to its ligand--hyaluronic acid (HA)--and regulates crucial processes such as cell differentiation, proliferation and migration.	ha	81-83	CD44 molecule (Indian blood group)	Homo sapiens	0-4
24503496-1	2013	BACKGROUND/AIMS: The aim of our study was to reveal the role of CD44-Hyaluronic acid (HA) in the homing and improving renal function of systemically transplanted MSCs in chronic renal failure.	ha	86-88	CD44 molecule (Indian blood group)	Rattus norvegicus	64-68
22169245-2	2012	Addition of 5mg/L of Humic acid sodium (HA), Suwannee River NOM (SRNOM) and Nordic Reservoir NOM (NRNOM) all accelerated the photodegradation of 2,4",5-trichlorobiphenyl (PCB 31) significantly, with a pseudo-first-order rate constant of 0.0933, 0.0651 and 0.0486 in the initial 12h, respectively.	ha	40-42	pyruvate carboxylase	Homo sapiens	171-174
21461916-1	2011	Collagen-hydroxyapatite (HA) scaffolds for the non-viral delivery of a plasmid encoding the osteoinductive protein bone morphogenetic protein (BMP)-7 were developed.	ha	25-27	bone morphogenetic protein 7	Homo sapiens	115-149