PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29684393-0	2018	Anti-pseudo-allergy effect of isoliquiritigenin is MRGPRX2-dependent.	isoliquiritigenin	30-47	MAS related GPR family member X2	Homo sapiens	51-58
30226314-8	2018	The mRNA and protein expression levels of MMP-2 and MMP-9 were decreased compared with control group (P<0.05 or P<0.01), and the expression levels in 80 mumol/L isoliquiritigenin group were lower than those in 20 mumol/L isoliquiritigenin group (P<0.05 or P<0.01).	isoliquiritigenin	167-184	matrix metallopeptidase 2	Homo sapiens	42-47
30226314-8	2018	The mRNA and protein expression levels of MMP-2 and MMP-9 were decreased compared with control group (P<0.05 or P<0.01), and the expression levels in 80 mumol/L isoliquiritigenin group were lower than those in 20 mumol/L isoliquiritigenin group (P<0.05 or P<0.01).	isoliquiritigenin	167-184	matrix metallopeptidase 9	Homo sapiens	52-57
30226314-8	2018	The mRNA and protein expression levels of MMP-2 and MMP-9 were decreased compared with control group (P<0.05 or P<0.01), and the expression levels in 80 mumol/L isoliquiritigenin group were lower than those in 20 mumol/L isoliquiritigenin group (P<0.05 or P<0.01).	isoliquiritigenin	227-244	matrix metallopeptidase 2	Homo sapiens	42-47
30226314-8	2018	The mRNA and protein expression levels of MMP-2 and MMP-9 were decreased compared with control group (P<0.05 or P<0.01), and the expression levels in 80 mumol/L isoliquiritigenin group were lower than those in 20 mumol/L isoliquiritigenin group (P<0.05 or P<0.01).	isoliquiritigenin	227-244	matrix metallopeptidase 9	Homo sapiens	52-57
30226314-9	2018	CONCLUSIONS: Isoliquiritigenin exhibits antitumor effects on glioma stem cells by inhibiting cell migration and invasion, which may be related to the down-regulation of MMP-2 and MMP-9.	isoliquiritigenin	13-30	matrix metallopeptidase 2	Homo sapiens	169-174
30226314-9	2018	CONCLUSIONS: Isoliquiritigenin exhibits antitumor effects on glioma stem cells by inhibiting cell migration and invasion, which may be related to the down-regulation of MMP-2 and MMP-9.	isoliquiritigenin	13-30	matrix metallopeptidase 9	Homo sapiens	179-184
29277717-9	2018	In addition, treatment with relatively high concentrations of isoliquiritigenin induced apoptosis, mainly associated with enhancing apoptosis regulator (Bax/Bcl-2) ratio.	isoliquiritigenin	62-79	BCL2 associated X, apoptosis regulator	Homo sapiens	153-156
29854090-0	2018	Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
29854090-0	2018	Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway.	isoliquiritigenin	0-17	heme oxygenase 1	Mus musculus	119-123
29277717-9	2018	In addition, treatment with relatively high concentrations of isoliquiritigenin induced apoptosis, mainly associated with enhancing apoptosis regulator (Bax/Bcl-2) ratio.	isoliquiritigenin	62-79	BCL2 apoptosis regulator	Homo sapiens	157-162
29277717-10	2018	Collectively, these findings indicate that isoliquiritigenin modulates cyclin B1-CDK1 for G2/M arrest, together with an alteration of cell cycle regulators and apoptotic factors in human prostate cancer cells.	isoliquiritigenin	43-60	cyclin B1	Homo sapiens	71-80
29277717-10	2018	Collectively, these findings indicate that isoliquiritigenin modulates cyclin B1-CDK1 for G2/M arrest, together with an alteration of cell cycle regulators and apoptotic factors in human prostate cancer cells.	isoliquiritigenin	43-60	cyclin dependent kinase 1	Homo sapiens	81-85
28887870-8	2018	Isoliquiritigenin, an inhibitor of NALP3, decreased the rate of wound repair in WT mice.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	35-40
29766025-0	2018	Isoliquiritigenin Inhibits IL-1beta-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes.	isoliquiritigenin	0-17	interleukin 1 beta	Rattus norvegicus	27-35
29766025-3	2018	In this study, the effect of isoliquiritigenin on IL-1beta-induced production of matrix metalloproteinase and nuclear factor kappaB (NF-kappaB) activation was analyzed.	isoliquiritigenin	29-46	interleukin 1 beta	Rattus norvegicus	50-58
29766025-8	2018	A 10-muM isoliquiritigenin treatment significantly inhibited IL-1beta-induced NF-kappaB activation and these MMPs production on chondrocytes.	isoliquiritigenin	9-26	interleukin 1 beta	Rattus norvegicus	61-69
29766025-8	2018	A 10-muM isoliquiritigenin treatment significantly inhibited IL-1beta-induced NF-kappaB activation and these MMPs production on chondrocytes.	isoliquiritigenin	9-26	matrix metallopeptidase 1	Rattus norvegicus	109-113
29936511-0	2018	Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion by Regulating the PI3K/Akt Signalling Pathway.	isoliquiritigenin	0-17	AKT serine/threonine kinase 1	Homo sapiens	102-105
29766025-9	2018	Injecting isoliquiritigenin into rat knee joint also inhibited IL-1beta-induced NF-kappaB activation and MMPs production in articular cartilage.	isoliquiritigenin	10-27	interleukin 1 beta	Rattus norvegicus	63-71
29766025-9	2018	Injecting isoliquiritigenin into rat knee joint also inhibited IL-1beta-induced NF-kappaB activation and MMPs production in articular cartilage.	isoliquiritigenin	10-27	matrix metallopeptidase 1	Rattus norvegicus	105-109
29766025-10	2018	Isoliquiritigenin treatment inhibited IL-1beta-induced MMPs production and NF-kappaB activation both in vitro and in vivo, suggesting a potential therapeutic role of isoliquiritigenin to treat osteoarthritis.	isoliquiritigenin	0-17	interleukin 1 beta	Rattus norvegicus	38-46
29766025-10	2018	Isoliquiritigenin treatment inhibited IL-1beta-induced MMPs production and NF-kappaB activation both in vitro and in vivo, suggesting a potential therapeutic role of isoliquiritigenin to treat osteoarthritis.	isoliquiritigenin	0-17	matrix metallopeptidase 1	Rattus norvegicus	55-59
29766025-10	2018	Isoliquiritigenin treatment inhibited IL-1beta-induced MMPs production and NF-kappaB activation both in vitro and in vivo, suggesting a potential therapeutic role of isoliquiritigenin to treat osteoarthritis.	isoliquiritigenin	166-183	interleukin 1 beta	Rattus norvegicus	38-46
29091873-0	2018	Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling.	isoliquiritigenin	26-43	AKT serine/threonine kinase 1	Homo sapiens	118-121
29091873-0	2018	Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling.	isoliquiritigenin	26-43	mechanistic target of rapamycin kinase	Homo sapiens	122-126
29270182-7	2017	The first key enzyme exclusively involved in glyceollin synthesis is chalcone reductase (CHR) which coacts with chalcone synthase for the production of isoliquiritigenin, the precursor for glyceollin biosynthesis.	isoliquiritigenin	152-169	chalcone reductase	Glycine max	69-87
29393276-0	2018	Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation.	isoliquiritigenin	0-17	interferon activated gene 208	Mus musculus	115-140
29393276-7	2018	Isoliquiritigenin also inhibited the indomethacin-induced increase in cleaved caspase-1 and mature IL-1beta protein levels, whereas it did not affect the mRNA expression of NLRP3, ASC, caspase-1, and IL-1beta.	isoliquiritigenin	0-17	caspase 1	Mus musculus	78-87
29393276-7	2018	Isoliquiritigenin also inhibited the indomethacin-induced increase in cleaved caspase-1 and mature IL-1beta protein levels, whereas it did not affect the mRNA expression of NLRP3, ASC, caspase-1, and IL-1beta.	isoliquiritigenin	0-17	interleukin 1 beta	Mus musculus	99-107
29393276-7	2018	Isoliquiritigenin also inhibited the indomethacin-induced increase in cleaved caspase-1 and mature IL-1beta protein levels, whereas it did not affect the mRNA expression of NLRP3, ASC, caspase-1, and IL-1beta.	isoliquiritigenin	0-17	interleukin 1 beta	Mus musculus	200-208
29393276-8	2018	Protection against intestinal damage in isoliquiritigenin-treated mice was completely abolished with exogenous IL-1beta.	isoliquiritigenin	40-57	interleukin 1 beta	Mus musculus	111-119
29393276-10	2018	Isoliquiritigenin prevents NSAID-induced small intestinal damage by inhibiting NLRP3 inflammasome activation.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	79-84
29371998-0	2018	Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway.	isoliquiritigenin	21-38	sirtuin 1	Mus musculus	99-104
29270182-7	2017	The first key enzyme exclusively involved in glyceollin synthesis is chalcone reductase (CHR) which coacts with chalcone synthase for the production of isoliquiritigenin, the precursor for glyceollin biosynthesis.	isoliquiritigenin	152-169	chalcone reductase	Glycine max	89-92
28899510-6	2017	RESULTS: A total of 62 compounds at 10 microM showed protective effects against CCl4 to improve cell viability from 52.5% to >60%, and compounds 5 (licoflavone A), 104 (3,4-didehydroglabridin), 107 (isoliquiritigenin), 108 (3,4,3",4"-tetrahydroxychalcone), and 111 (licochalcone B) showed the most potent activities, improving cell viability to >80%.	isoliquiritigenin	202-219	C-C motif chemokine ligand 4	Homo sapiens	80-84
28870684-5	2017	It was found that pretreatment with IsoLQ attenuates cisplatin-induced cell death, ROS production, and activation of caspase-3.	isoliquiritigenin	36-41	caspase 3	Homo sapiens	117-126
28870684-6	2017	IsoLQ also induced heme oxygenase-1 (HO-1) expression that may be associated with nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear translocation.	isoliquiritigenin	0-5	heme oxygenase 1	Homo sapiens	19-35
28870684-6	2017	IsoLQ also induced heme oxygenase-1 (HO-1) expression that may be associated with nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear translocation.	isoliquiritigenin	0-5	heme oxygenase 1	Homo sapiens	37-41
28870684-6	2017	IsoLQ also induced heme oxygenase-1 (HO-1) expression that may be associated with nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear translocation.	isoliquiritigenin	0-5	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
28870684-10	2017	These results suggest that IsoLQ has a protective effect on cisplatin-induced toxicity in LLC-PK1 cells, in part through induction of HO-1, without interfering with the antineoplastic activity of this agent in T24 cells.	isoliquiritigenin	27-32	heme oxygenase 1	Sus scrofa	134-138
29039445-0	2017	Isoliquiritigenin suppresses IL-1beta induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-kappaB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection.	isoliquiritigenin	0-17	interleukin 1 beta	Mus musculus	29-37
29163554-0	2017	Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-kappaB Pathway in Macrophages and in Acute Lung Injury.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-71
29163554-0	2017	Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-kappaB Pathway in Macrophages and in Acute Lung Injury.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	88-115
29163554-3	2017	Isoliquiritigenin (ISL), a flavonoid from the liquorice compound, is suggested to be a regulator of the above pathways, but the mechanisms of how the NLRP3/NF-kappaB pathway interacts with Nrf2 and its protective effects in ALI remain unknown.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	150-155
29163554-3	2017	Isoliquiritigenin (ISL), a flavonoid from the liquorice compound, is suggested to be a regulator of the above pathways, but the mechanisms of how the NLRP3/NF-kappaB pathway interacts with Nrf2 and its protective effects in ALI remain unknown.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	189-193
29163554-3	2017	Isoliquiritigenin (ISL), a flavonoid from the liquorice compound, is suggested to be a regulator of the above pathways, but the mechanisms of how the NLRP3/NF-kappaB pathway interacts with Nrf2 and its protective effects in ALI remain unknown.	isoliquiritigenin	19-22	NLR family, pyrin domain containing 3	Mus musculus	150-155
29163554-3	2017	Isoliquiritigenin (ISL), a flavonoid from the liquorice compound, is suggested to be a regulator of the above pathways, but the mechanisms of how the NLRP3/NF-kappaB pathway interacts with Nrf2 and its protective effects in ALI remain unknown.	isoliquiritigenin	19-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	189-193
28693160-1	2017	The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL).	isoliquiritigenin	183-200	cyclin dependent kinase 2	Homo sapiens	71-96
28970510-5	2017	Measurements using high-performance liquid chromatography (HPLC) showed that the activity of beta-glucuronidase could be increased by 2.66-fold via the addition of ISL to a beta-glucuronidase solution that contained GL at a 3:10 molar ratio of ISL to GL.	isoliquiritigenin	164-167	glucuronidase beta	Homo sapiens	93-111
28970510-5	2017	Measurements using high-performance liquid chromatography (HPLC) showed that the activity of beta-glucuronidase could be increased by 2.66-fold via the addition of ISL to a beta-glucuronidase solution that contained GL at a 3:10 molar ratio of ISL to GL.	isoliquiritigenin	164-167	glucuronidase beta	Homo sapiens	173-191
29212198-0	2017	Targeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulation.	isoliquiritigenin	54-71	heat shock protein 5	Mus musculus	81-86
29212198-4	2017	Treatment of isoliquiritigenin not only inhibited the self-renewal ability but also reduced the expression of CSC markers, including the ALDH1 and CD44.	isoliquiritigenin	13-30	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	137-142
29212198-4	2017	Treatment of isoliquiritigenin not only inhibited the self-renewal ability but also reduced the expression of CSC markers, including the ALDH1 and CD44.	isoliquiritigenin	13-30	CD44 antigen	Mus musculus	147-151
29212198-6	2017	Most importantly, we showed that isoliquiritigenin potentiated chemotherapy along with downregulated expression of an ABC transporter that is associated with drug resistance, ABCG2.	isoliquiritigenin	33-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	175-180
29212198-8	2017	Our results suggested that administration of isoliquiritigenin reduced the protein expression of mRNA and membrane GRP78, a critical mediator of tumor biology.	isoliquiritigenin	45-62	heat shock protein 5	Mus musculus	115-120
29212198-9	2017	Overexpression of GRP78 reversed the inhibitory effect of isoliquiritigenin on OSCC-CSCs.	isoliquiritigenin	58-75	heat shock protein 5	Mus musculus	18-23
28827662-0	2017	Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis.	isoliquiritigenin	0-17	microRNA 374a	Homo sapiens	28-36
28827662-0	2017	Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis.	isoliquiritigenin	0-17	phosphatase and tensin homolog	Homo sapiens	37-41
28827662-0	2017	Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis.	isoliquiritigenin	0-17	AKT serine/threonine kinase 1	Homo sapiens	42-45
28827662-6	2017	We also verified the anti-cancer effect of isoliquiritigenin on migration and invasion, and identified highly expressed miR-374a as one of the main microRNAs down-regulated by isoliquiritigenin treatment in breast cancer.	isoliquiritigenin	176-193	microRNA 374a	Homo sapiens	120-128
28827662-7	2017	Further study displayed that isoliquiritigenin increased PTEN expression through the decrease of miR-374a expression to inhibit the aberrant Akt signaling.	isoliquiritigenin	29-46	phosphatase and tensin homolog	Homo sapiens	57-61
28827662-7	2017	Further study displayed that isoliquiritigenin increased PTEN expression through the decrease of miR-374a expression to inhibit the aberrant Akt signaling.	isoliquiritigenin	29-46	microRNA 374a	Homo sapiens	97-105
28827662-7	2017	Further study displayed that isoliquiritigenin increased PTEN expression through the decrease of miR-374a expression to inhibit the aberrant Akt signaling.	isoliquiritigenin	29-46	AKT serine/threonine kinase 1	Homo sapiens	141-144
28827662-8	2017	Our findings suggest isoliquiritigenin as a novel anti-cancer candidate significantly regulating miR-374a/PTEN/Akt axis in microRNA-based breast cancer therapies.	isoliquiritigenin	21-38	microRNA 374a	Homo sapiens	97-105
28827662-8	2017	Our findings suggest isoliquiritigenin as a novel anti-cancer candidate significantly regulating miR-374a/PTEN/Akt axis in microRNA-based breast cancer therapies.	isoliquiritigenin	21-38	phosphatase and tensin homolog	Homo sapiens	106-110
28827662-8	2017	Our findings suggest isoliquiritigenin as a novel anti-cancer candidate significantly regulating miR-374a/PTEN/Akt axis in microRNA-based breast cancer therapies.	isoliquiritigenin	21-38	AKT serine/threonine kinase 1	Homo sapiens	111-114
28716056-1	2017	BACKGROUND: Isoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/AKT signaling pathway.	isoliquiritigenin	12-29	AKT serine/threonine kinase 1	Homo sapiens	120-123
28716056-1	2017	BACKGROUND: Isoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/AKT signaling pathway.	isoliquiritigenin	31-34	AKT serine/threonine kinase 1	Homo sapiens	120-123
28970510-4	2017	In this study, we identified that isoliquiritigenin (ISL), as one of chemical compositions from the total flavonoids glycyrrhiza (TFG), can significantly enhance beta-glucuronidase activity in vitro.	isoliquiritigenin	34-51	glucuronidase beta	Homo sapiens	162-180
28970510-4	2017	In this study, we identified that isoliquiritigenin (ISL), as one of chemical compositions from the total flavonoids glycyrrhiza (TFG), can significantly enhance beta-glucuronidase activity in vitro.	isoliquiritigenin	53-56	glucuronidase beta	Homo sapiens	162-180
28528294-0	2017	Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.	isoliquiritigenin	0-17	sirtuin 1	Mus musculus	86-91
28528294-2	2017	We have evaluated hyperglycaemia-induced alteration of SIRT1 signalling and the effect of isoliquiritigenin (ILQ) on SIRT1-directed AMP kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) signalling in peripheral nerves of streptozotocin (STZ) (55 mg/kg, ip)-induced diabetic rats and in high glucose (30 mM)-exposed neuro2a (N2A) cells.	isoliquiritigenin	90-107	sirtuin 1	Rattus norvegicus	117-122
28528294-2	2017	We have evaluated hyperglycaemia-induced alteration of SIRT1 signalling and the effect of isoliquiritigenin (ILQ) on SIRT1-directed AMP kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) signalling in peripheral nerves of streptozotocin (STZ) (55 mg/kg, ip)-induced diabetic rats and in high glucose (30 mM)-exposed neuro2a (N2A) cells.	isoliquiritigenin	90-107	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	132-142
28528294-2	2017	We have evaluated hyperglycaemia-induced alteration of SIRT1 signalling and the effect of isoliquiritigenin (ILQ) on SIRT1-directed AMP kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) signalling in peripheral nerves of streptozotocin (STZ) (55 mg/kg, ip)-induced diabetic rats and in high glucose (30 mM)-exposed neuro2a (N2A) cells.	isoliquiritigenin	90-107	PPARG coactivator 1 alpha	Rattus norvegicus	154-222
28560439-0	2017	Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway.	isoliquiritigenin	0-17	Janus kinase 2	Homo sapiens	124-128
28560439-0	2017	Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway.	isoliquiritigenin	0-17	signal transducer and activator of transcription 3	Homo sapiens	129-134
28693160-1	2017	The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL).	isoliquiritigenin	183-200	cyclin dependent kinase 2	Homo sapiens	98-102
28693160-1	2017	The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL).	isoliquiritigenin	202-205	cyclin dependent kinase 2	Homo sapiens	71-96
28693160-1	2017	The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL).	isoliquiritigenin	202-205	cyclin dependent kinase 2	Homo sapiens	98-102
28610608-0	2017	Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-kappaB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Rattus norvegicus	139-144
28610608-0	2017	Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-kappaB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway.	isoliquiritigenin	0-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	182-186
28610608-2	2017	Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated antioxidant system, negatively regulate nuclear factor-kappaB (NF-kappaB) and nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathways, but its role and potential molecular mechanisms in the pathology following ICH remain unclear.	isoliquiritigenin	0-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-125
28610608-2	2017	Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated antioxidant system, negatively regulate nuclear factor-kappaB (NF-kappaB) and nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathways, but its role and potential molecular mechanisms in the pathology following ICH remain unclear.	isoliquiritigenin	0-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131
28610608-2	2017	Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated antioxidant system, negatively regulate nuclear factor-kappaB (NF-kappaB) and nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathways, but its role and potential molecular mechanisms in the pathology following ICH remain unclear.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Rattus norvegicus	220-271
28610608-2	2017	Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated antioxidant system, negatively regulate nuclear factor-kappaB (NF-kappaB) and nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathways, but its role and potential molecular mechanisms in the pathology following ICH remain unclear.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Rattus norvegicus	273-278
28012970-0	2017	Isoliquiritigenin inhibits TNF-alpha-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	27-36
28615942-0	2017	iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability.	isoliquiritigenin	61-78	interferon gamma inducible protein 47	Mus musculus	0-4
28410220-0	2017	Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3beta signaling.	isoliquiritigenin	25-42	CREB regulated transcription coactivator 2	Mus musculus	80-86
28410220-0	2017	Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3beta signaling.	isoliquiritigenin	25-42	AKT serine/threonine kinase 1	Homo sapiens	87-90
28410220-0	2017	Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3beta signaling.	isoliquiritigenin	25-42	glycogen synthase kinase 3 beta	Homo sapiens	91-99
28012970-0	2017	Isoliquiritigenin inhibits TNF-alpha-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells.	isoliquiritigenin	0-17	high mobility group box 1	Homo sapiens	56-81
28012970-0	2017	Isoliquiritigenin inhibits TNF-alpha-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells.	isoliquiritigenin	0-17	histone deacetylase 9	Homo sapiens	104-108
27869741-0	2016	Isoliquiritigenin Attenuates Atherogenesis in Apolipoprotein E-Deficient Mice.	isoliquiritigenin	0-17	apolipoprotein E	Mus musculus	46-62
26593436-6	2016	Moreover, isoLQ induced the activation of nuclear factor erythroid 2-related factor-2 (Nrf2), as indicated by an increase in its nuclear translocation and antioxidant response element-luciferase activity.	isoliquiritigenin	10-15	NFE2 like bZIP transcription factor 2	Homo sapiens	42-85
26593436-6	2016	Moreover, isoLQ induced the activation of nuclear factor erythroid 2-related factor-2 (Nrf2), as indicated by an increase in its nuclear translocation and antioxidant response element-luciferase activity.	isoliquiritigenin	10-15	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
26593436-10	2016	CONCLUSION: These findings are considered as scientific evidence that isoLQ in licorice has the function of being a hepatic protectant against oxidative damages through ERK-mediated Nrf2 activation.	isoliquiritigenin	70-75	mitogen-activated protein kinase 1	Homo sapiens	169-172
26593436-10	2016	CONCLUSION: These findings are considered as scientific evidence that isoLQ in licorice has the function of being a hepatic protectant against oxidative damages through ERK-mediated Nrf2 activation.	isoliquiritigenin	70-75	NFE2 like bZIP transcription factor 2	Homo sapiens	182-186
27880803-9	2016	We also found that the BMP agonist isoliquiritigenin (ISL) can partially rescue lower jaw formation and edn1 expression in wdr68 mutants.	isoliquiritigenin	35-52	endothelin 1	Danio rerio	104-108
27880803-9	2016	We also found that the BMP agonist isoliquiritigenin (ISL) can partially rescue lower jaw formation and edn1 expression in wdr68 mutants.	isoliquiritigenin	35-52	ddb1 and cul4 associated factor 7	Danio rerio	123-128
27880803-9	2016	We also found that the BMP agonist isoliquiritigenin (ISL) can partially rescue lower jaw formation and edn1 expression in wdr68 mutants.	isoliquiritigenin	54-57	endothelin 1	Danio rerio	104-108
27880803-9	2016	We also found that the BMP agonist isoliquiritigenin (ISL) can partially rescue lower jaw formation and edn1 expression in wdr68 mutants.	isoliquiritigenin	54-57	ddb1 and cul4 associated factor 7	Danio rerio	123-128
27770720-3	2016	Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2.	isoliquiritigenin	26-43	nitric oxide synthase 2	Homo sapiens	237-241
27770720-3	2016	Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2.	isoliquiritigenin	26-43	tumor necrosis factor	Homo sapiens	282-290
27770720-3	2016	Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2.	isoliquiritigenin	26-43	C-C motif chemokine ligand 2	Homo sapiens	295-299
26771170-0	2016	Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway.	isoliquiritigenin	0-17	mitogen-activated protein kinase 1	Mus musculus	95-99
27539609-0	2016	Isoliquiritigenin suppresses tumor necrosis factor-alpha-induced inflammation via peroxisome proliferator-activated receptor-gamma in intestinal epithelial cells.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	29-56
27539609-0	2016	Isoliquiritigenin suppresses tumor necrosis factor-alpha-induced inflammation via peroxisome proliferator-activated receptor-gamma in intestinal epithelial cells.	isoliquiritigenin	0-17	peroxisome proliferator activated receptor gamma	Homo sapiens	82-130
27681719-11	2016	In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels.	isoliquiritigenin	61-78	tumor protein p53	Homo sapiens	106-109
27681719-11	2016	In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels.	isoliquiritigenin	61-78	BCL2 associated X, apoptosis regulator	Homo sapiens	111-114
27681719-11	2016	In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels.	isoliquiritigenin	61-78	collagen type XI alpha 2 chain	Homo sapiens	171-175
29441915-0	2016	Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
29441915-9	2016	Pretreatment with isoliquiritigenin significantly prevented the triptolide-induced hepatotoxicity indicated by reduced activities of AST, ALT, ALP and LDH.	isoliquiritigenin	18-35	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	133-136
29441915-9	2016	Pretreatment with isoliquiritigenin significantly prevented the triptolide-induced hepatotoxicity indicated by reduced activities of AST, ALT, ALP and LDH.	isoliquiritigenin	18-35	glutamic pyruvic transaminase, soluble	Mus musculus	138-141
29441915-10	2016	Moreover, isoliquiritigenin pretreatment also prevented from triptolide-induced hepatotoxicity by inhibiting MDA and restoring the levels of GSH, GPx, SOD and CAT.	isoliquiritigenin	10-27	peroxiredoxin 6 pseudogene 2	Mus musculus	146-149
29441915-10	2016	Moreover, isoliquiritigenin pretreatment also prevented from triptolide-induced hepatotoxicity by inhibiting MDA and restoring the levels of GSH, GPx, SOD and CAT.	isoliquiritigenin	10-27	catalase	Mus musculus	159-162
29441915-12	2016	Furthermore, the results indicated that isoliquiritigenin pretreatment caused an increase in the protein expression of Nrf2.	isoliquiritigenin	40-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
29441915-13	2016	These results indicated that isoliquiritigenin could protect against triptolide-induced hepatotoxicity via activation of the Nrf2 pathway.	isoliquiritigenin	29-46	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
27980562-1	2016	Low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle (LMWH-ISL-SLN) was developed for injective application.	isoliquiritigenin	38-55	sarcolipin	Homo sapiens	98-101
27980562-8	2016	The in-vitro release experiments demonstrated isoliquiritigenin release from LMWH-ISL-SLN was in line with Weibull"s distribution law.	isoliquiritigenin	46-63	sarcolipin	Homo sapiens	86-89
27980562-10	2016	The pharmacokinetics results of LMWH-ISL-SLN showed that the area under the concentration-time curve (AUC0  )of LMWH-ISL-SLN was greater than that for the isoliquiritigenin solution in plasma.	isoliquiritigenin	155-172	sarcolipin	Homo sapiens	41-44
27273195-5	2016	Hesperetin and isoliquiritigenin, which showed antagonistic effects against both CRFR1 and 5-HT2CR, were distributed in the plasma and brain of male Sprague-Dawley rats after a single oral administration of RKT.	isoliquiritigenin	15-32	corticotropin releasing hormone receptor 1	Rattus norvegicus	81-86
27273195-5	2016	Hesperetin and isoliquiritigenin, which showed antagonistic effects against both CRFR1 and 5-HT2CR, were distributed in the plasma and brain of male Sprague-Dawley rats after a single oral administration of RKT.	isoliquiritigenin	15-32	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	91-98
27607416-14	2016	Inhibition of NLRP3 activation using 10 muM isoliquiritigenin significantly (P < 0.001) inhibited ox-LDL induced cytotoxicity.	isoliquiritigenin	44-61	NLR family pyrin domain containing 3	Homo sapiens	14-19
26771170-4	2016	Interestingly, the reduction of body weight and colon length, increase of diarrhea, bloody stool, DAI scores and MPO activity, and histologic disturbances in DSS-induced colitis were recovered by isoLQ treatment.	isoliquiritigenin	196-201	myeloperoxidase	Mus musculus	113-116
26771170-5	2016	Also, isoLQ treatment suppressed the phosphorylation of ERK1/2 and p38, and the activation of NK-kappaB compared to those in DSS-induced colitis mice.	isoliquiritigenin	6-11	mitogen-activated protein kinase 3	Mus musculus	56-62
26771170-5	2016	Also, isoLQ treatment suppressed the phosphorylation of ERK1/2 and p38, and the activation of NK-kappaB compared to those in DSS-induced colitis mice.	isoliquiritigenin	6-11	mitogen-activated protein kinase 14	Mus musculus	67-70
26771170-7	2016	All of these results suggested that isoLQ has potential activity to ameliorate the DSS-induced colitis through the inhibition of MAPK pathway.	isoliquiritigenin	36-41	mitogen-activated protein kinase 1	Mus musculus	129-133
26904149-0	2016	The Protective Effects of Isoliquiritigenin and Glycyrrhetinic Acid against Triptolide-Induced Oxidative Stress in HepG2 Cells Involve Nrf2 Activation.	isoliquiritigenin	26-43	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
26473469-4	2015	Licorice species could also induce NQO1, as they contain the Michael acceptors isoliquiritigenin (LigC) found in Glycyrrhiza glabra (GG), G. uralensis (GU), G. inflata (GI), and licochalcone A (LicA) which is only found in GI.	isoliquiritigenin	79-96	NAD(P)H dehydrogenase, quinone 1	Mus musculus	35-39
26626189-8	2016	Small food-derived inducers of the Nrf2/ARE pathway including l-sulforaphane from broccoli and isoliquiritigenin from licorice displayed promising protection of mitochondrial function in models of oxidative stress and neurodegenerative diseases and represent a novel approach to prevent and treat aging-associated neurodegenerative diseases.	isoliquiritigenin	95-112	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
26734591-0	2015	Isoliquiritigenin Inhibits Metastatic Breast Cancer Cell-induced Receptor Activator of Nuclear Factor Kappa-B Ligand/Osteoprotegerin Ratio in Human Osteoblastic Cells.	isoliquiritigenin	0-17	TNF superfamily member 11	Homo sapiens	65-116
26734591-0	2015	Isoliquiritigenin Inhibits Metastatic Breast Cancer Cell-induced Receptor Activator of Nuclear Factor Kappa-B Ligand/Osteoprotegerin Ratio in Human Osteoblastic Cells.	isoliquiritigenin	0-17	TNF receptor superfamily member 11b	Homo sapiens	117-132
26109306-0	2015	[Isoliquiritigenin relaxes the cerebral basilar artery by enhancing BKCa current in spontaneously hypertensive rat: role of sGC/cGMP].	isoliquiritigenin	1-18	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	68-72
26722447-8	2015	Finally, Caspase 3 activity detection results suggested that isoliquiritigenin could significantly increase the activity of Caspase 3 (P < 0.05).	isoliquiritigenin	61-78	caspase 3	Homo sapiens	9-18
26722447-8	2015	Finally, Caspase 3 activity detection results suggested that isoliquiritigenin could significantly increase the activity of Caspase 3 (P < 0.05).	isoliquiritigenin	61-78	caspase 3	Homo sapiens	124-133
26722447-9	2015	CONCLUSION: Isoliquiritigenin had a reversible inhibitory effect on TOP I activity, reduced the rate of single strand DNA unwinding in tumor cells, and thus played an important role in inducing the apoptosis of U87 glioma cells.	isoliquiritigenin	12-29	DNA topoisomerase I	Homo sapiens	68-73
26722447-1	2015	OBJECTIVE: To investigate the effect of isoliquiritigenin on the activity of DNA topoisomerase (TOP I) and its inhibitory effect on the growth of U87 glioma cells.	isoliquiritigenin	40-57	DNA topoisomerase I	Homo sapiens	96-101
26722447-2	2015	METHODS: This study investigated the inhibitory effect of isoliquiritigenin on the growth of U87 glioma cells and its cytotoxicity by MTT method and determined the effect of isoliquiritigenin on TOP I activity by agarose gel electrophoresis.	isoliquiritigenin	174-191	DNA topoisomerase I	Homo sapiens	195-200
26722447-3	2015	On this basis, we studied the interaction between isoliquiritigenin and TOP I and DNA.	isoliquiritigenin	50-67	DNA topoisomerase I	Homo sapiens	72-77
26722447-4	2015	Finally, we further discussed the effect of isoliquiritigenin on the activity of Caspase 3, the apoptosis protein of U87 glioma cells.	isoliquiritigenin	44-61	caspase 3	Homo sapiens	81-90
26722447-6	2015	Agarose gel electrophoresis showed that isoliquiritigenin had significant inhibitory effect on TOP I activity.	isoliquiritigenin	40-57	DNA topoisomerase I	Homo sapiens	95-100
26722447-7	2015	Molecular simulation results indicated that isoliquiritigenin took priority of binding to the active center of TOP I, and formed hydrogen bonds with the catalytic site Try723.	isoliquiritigenin	44-61	DNA topoisomerase I	Homo sapiens	111-116
26188513-0	2015	The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-alpha/JNK/IRS signaling.	isoliquiritigenin	14-31	tumor necrosis factor	Mus musculus	107-116
26188513-0	2015	The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-alpha/JNK/IRS signaling.	isoliquiritigenin	14-31	mitogen-activated protein kinase 8	Mus musculus	117-120
26188513-0	2015	The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-alpha/JNK/IRS signaling.	isoliquiritigenin	14-31	isoleucine-tRNA synthetase	Mus musculus	121-124
26101703-2	2015	Here we investigate how isoliquiritigenin (ISL), a natural antioxidant, inhibits the Nrf2-dependent antioxidant pathway and enhances the radiosensitivity of HepG2 cells and HepG2 xenografts.	isoliquiritigenin	24-41	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
25875506-6	2015	Isoliquiritigenin prevented the occurrence of gastric ulcers by indomethacin, which is associated with increased gastric mucous secretion because the pretreatment with isoliquiritigenin presumably counteracted the decreased cyclooxygenase 2 by indomethacin.	isoliquiritigenin	0-17	prostaglandin-endoperoxide synthase 2	Mus musculus	224-240
25875506-6	2015	Isoliquiritigenin prevented the occurrence of gastric ulcers by indomethacin, which is associated with increased gastric mucous secretion because the pretreatment with isoliquiritigenin presumably counteracted the decreased cyclooxygenase 2 by indomethacin.	isoliquiritigenin	168-185	prostaglandin-endoperoxide synthase 2	Mus musculus	224-240
26101703-2	2015	Here we investigate how isoliquiritigenin (ISL), a natural antioxidant, inhibits the Nrf2-dependent antioxidant pathway and enhances the radiosensitivity of HepG2 cells and HepG2 xenografts.	isoliquiritigenin	43-46	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
26315837-0	2015	Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.	isoliquiritigenin	0-17	interferon gamma	Homo sapiens	27-43
25557030-0	2015	A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation.	isoliquiritigenin	60-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
25557030-11	2015	Isoliquiritigenin significantly up-regulated the expression of Nrf2 and its downstream detoxification genes UDP-glucuronosyltransferase 1A1 (UGT1A1), glutamate cysteine ligase (GCL), multidrug resistance protein 2 (MRP2) and bile salt export pump (BSEP) in vitro and in vivo.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
25557030-12	2015	Additionally, isoliquiritigenin showed Nrf2-dependent transactivation of UGT1A1, GCLC and MRP2.	isoliquiritigenin	14-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
25557030-13	2015	CONCLUSIONS: Isoliquiritigenin, isolated from Glycyrrhiza uralensis, stimulates detoxification system via Nrf2 activation, which could be a potential protective mechanism of licorice.	isoliquiritigenin	13-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
25782036-0	2015	Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-beta toxicity in Caenorhabditis elegans.	isoliquiritigenin	38-55	amyloid beta precursor protein	Homo sapiens	67-79
25782036-6	2015	The number of amyloid-beta aggregates decreased by 30% after treatment with isoliquiritigenin, the methanol extract could reduce the number by 14%, liquiritigenin and glycyrrhizic acid by 15%, and the aglycon of glycyrrhizic acid, glycyrrhetinic acid, by 20%.	isoliquiritigenin	76-93	amyloid beta precursor protein	Homo sapiens	14-26
25450236-2	2015	This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury induced by CCl4 in rats.	isoliquiritigenin	49-66	C-C motif chemokine ligand 4	Rattus norvegicus	120-124
25450236-2	2015	This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury induced by CCl4 in rats.	isoliquiritigenin	68-73	C-C motif chemokine ligand 4	Rattus norvegicus	120-124
25782036-7	2015	Both extracts and isoliquiritigenin also showed significant activity against acute amyloid-beta toxicity in transgenic C. elegans that express human amyloid-beta peptides, delaying the paralysis in this model by 1.8 h and 1.1 h, respectively.	isoliquiritigenin	18-35	amyloid beta precursor protein	Homo sapiens	83-95
25782036-7	2015	Both extracts and isoliquiritigenin also showed significant activity against acute amyloid-beta toxicity in transgenic C. elegans that express human amyloid-beta peptides, delaying the paralysis in this model by 1.8 h and 1.1 h, respectively.	isoliquiritigenin	18-35	amyloid beta precursor protein	Homo sapiens	149-161
25450236-6	2015	In addition, pretreatment with isoLQ inhibited CCl4-induced reduction of cytochrome P450 2E1 protein and mRNA expression as well as activity in the liver.	isoliquiritigenin	31-36	C-C motif chemokine ligand 4	Rattus norvegicus	47-51
25450236-6	2015	In addition, pretreatment with isoLQ inhibited CCl4-induced reduction of cytochrome P450 2E1 protein and mRNA expression as well as activity in the liver.	isoliquiritigenin	31-36	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	73-92
25450236-7	2015	Moreover, isoLQ pretreatment reversed the decrease in hepatic antioxidant capacity induced by CCl4 as well as suppressed expression of tumor necrosis factor-alpha and cyclooxigenase-2 in the liver.	isoliquiritigenin	10-15	C-C motif chemokine ligand 4	Rattus norvegicus	94-98
25450236-7	2015	Moreover, isoLQ pretreatment reversed the decrease in hepatic antioxidant capacity induced by CCl4 as well as suppressed expression of tumor necrosis factor-alpha and cyclooxigenase-2 in the liver.	isoliquiritigenin	10-15	tumor necrosis factor	Rattus norvegicus	135-162
25450236-8	2015	These results suggest that isoLQ has a protective effect against CCl4-induced liver damage through induction of antioxidant and anti-inflammatory activities.	isoliquiritigenin	27-32	C-C motif chemokine ligand 4	Rattus norvegicus	65-69
26315837-0	2015	Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.	isoliquiritigenin	0-17	Janus kinase 1	Homo sapiens	124-128
26315837-0	2015	Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.	isoliquiritigenin	0-17	signal transducer and activator of transcription 1	Homo sapiens	129-134
26315837-0	2015	Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.	isoliquiritigenin	0-17	interferon regulatory factor 3	Homo sapiens	136-140
26315837-0	2015	Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.	isoliquiritigenin	0-17	MYD88 innate immune signal transduction adaptor	Homo sapiens	141-146
26315837-0	2015	Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.	isoliquiritigenin	0-17	mitogen-activated protein kinase 1	Homo sapiens	148-151
26315837-0	2015	Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.	isoliquiritigenin	0-17	mitogen-activated protein kinase 8	Homo sapiens	158-161
26315837-0	2015	Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.	isoliquiritigenin	0-17	AKT serine/threonine kinase 1	Homo sapiens	176-179
26315837-2	2015	The present study aimed to explore the effect of isoliquiritigenin (ISL) on the expression of genes induced by IFN-gamma in vitro, and to elucidate the underlying molecular mechanisms.	isoliquiritigenin	49-66	interferon gamma	Homo sapiens	111-120
25368326-0	2014	Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.	isoliquiritigenin	0-17	epidermal growth factor receptor	Homo sapiens	150-154
25918249-0	2015	Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation.	isoliquiritigenin	17-34	WNT inhibitory factor 1	Homo sapiens	114-118
25194164-0	2014	Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via beta-catenin/ABCG2 signaling.	isoliquiritigenin	17-34	heat shock protein family A (Hsp70) member 5	Homo sapiens	43-48
25194164-0	2014	Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via beta-catenin/ABCG2 signaling.	isoliquiritigenin	17-34	catenin beta 1	Homo sapiens	96-108
25194164-0	2014	Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via beta-catenin/ABCG2 signaling.	isoliquiritigenin	17-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	109-114
25194164-3	2014	In a pilot screening study, we found that the natural compound isoliquiritigenin (ISL) blocked beta-catenin transcription activity with the highest inhibition ratio.	isoliquiritigenin	63-80	catenin beta 1	Homo sapiens	95-107
25110319-0	2014	The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells.	isoliquiritigenin	23-40	aryl hydrocarbon receptor	Homo sapiens	73-76
23786711-0	2013	Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.	isoliquiritigenin	34-51	arachidonate 5-lipoxygenase	Homo sapiens	126-140
25094029-0	2014	Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.	isoliquiritigenin	48-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
25094029-3	2014	Here, we demonstrate that isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, inhibits human breast cancer metastasis by preventing anoikis resistance, migration and invasion through downregulating cyclooxygenase (COX)-2 and cytochrome P450 (CYP) 4A signaling.	isoliquiritigenin	26-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-230
25094029-3	2014	Here, we demonstrate that isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, inhibits human breast cancer metastasis by preventing anoikis resistance, migration and invasion through downregulating cyclooxygenase (COX)-2 and cytochrome P450 (CYP) 4A signaling.	isoliquiritigenin	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-230
23401151-5	2013	Moreover, treatment with licochalcone A and isoliquiritigenin as the active components, whose contents are increased by the roasting process, remarkably suppressed RANKL-induced osteoclast formation in BMMs, respectively.	isoliquiritigenin	44-61	TNF superfamily member 11	Homo sapiens	164-169
23881796-0	2013	Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation.	isoliquiritigenin	0-17	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
23165939-5	2013	Isoliquiritigenin, 7, 4"-dihydroxyflavone (7, 4"-DHF) and liquiritigenin significantly suppressed IL-4 and IL-5 production in a dose-dependent manner, 7, 4"-DHF being most potent.	isoliquiritigenin	0-17	interleukin 4	Mus musculus	98-102
25026504-0	2014	Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6.	isoliquiritigenin	0-17	interleukin 6	Mus musculus	148-152
25026296-0	2014	MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin.	isoliquiritigenin	136-153	microRNA 25	Homo sapiens	0-11
25026296-3	2014	Here, we report a novel function of isoliquiritigenin (ISL) as a natural inhibitor of autophagy-related miR-25 in killing drug-resistant breast cancer cells.	isoliquiritigenin	36-53	microRNA 25	Homo sapiens	104-110
25026296-3	2014	Here, we report a novel function of isoliquiritigenin (ISL) as a natural inhibitor of autophagy-related miR-25 in killing drug-resistant breast cancer cells.	isoliquiritigenin	55-58	microRNA 25	Homo sapiens	104-110
25076036-4	2014	Detection of the transcription of CHR1 gene using quantitative real-time PCR (qRT-PCR) showed that the expression of CHR1 gene in transformed plants decreased 60%-99% compared to the recipient soybean, while the content of isoliquiritigenin, the precursors of daidzein, decreased 38.7%.	isoliquiritigenin	223-240	chalcone reductase CHR6	Glycine max	34-38
24214831-0	2013	Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells.	isoliquiritigenin	0-17	SKI proto-oncogene	Homo sapiens	118-121
24214831-2	2013	Isoliquiritigenin which is a constituent of licorice (Glycyrrhiza inflata), a plant commonly used in traditional Uyghur medicine in Xinjiang, China, was studied for antiproliferative and apoptotic activity in human cervical cancer cells, Ca Ski, SiHa, HeLa, and C-33A.	isoliquiritigenin	0-17	SKI proto-oncogene	Homo sapiens	241-244
24214831-5	2013	In Ca Ski cells, isoliquiritigenin led to a downregulation of HPV16 E6 expression associated with an increase of p53 and p21 levels, enhanced expression of Bax and decreased expression of Bcl-2 and Bid proform triggering dissipation of the mitochondrial membrane potential, released cytochrome c to the cytosol followed by activation of caspase cascade with cleavage of caspase-9, caspase-3, and PARP.	isoliquiritigenin	17-34	SKI proto-oncogene	Homo sapiens	6-9
23747687-0	2013	Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer.	isoliquiritigenin	0-17	AKT serine/threonine kinase 1	Homo sapiens	145-148
23747687-2	2013	Here, we demonstrate that isoliquiritigenin, a flavonoid phytoestrogen from licorice, induces growth inhibition and apoptosis through downregulating multiple key enzymes in AA metabolic network and the deactivation of PI3K/Akt in human breast cancer.	isoliquiritigenin	26-43	AKT serine/threonine kinase 1	Homo sapiens	223-226
23747687-6	2013	Conversely, the addition of exogenous eicosanoids, including PGE2, LTB4 and a 20-HETE analog (WIT003), and caspase inhibitors, or overexpression of constitutively active Akt reversed isoliquiritigenin-induced apoptosis.	isoliquiritigenin	183-200	AKT serine/threonine kinase 1	Homo sapiens	170-173
23747687-7	2013	Notably, isoliquiritigenin induced growth inhibition and apoptosis of MDA-MB-231 human breast cancer xenografts in nude mice, together with decreased intratumoral levels of eicosanoids and phospho-Akt (Thr(308)).	isoliquiritigenin	9-26	thymoma viral proto-oncogene 1	Mus musculus	197-200
23747687-8	2013	Collectively, these data suggest that isoliquiritigenin induces growth inhibition and apoptosis through downregulating AA metabolic network and the deactivation of PI3K/Akt in human breast cancer.	isoliquiritigenin	38-55	AKT serine/threonine kinase 1	Homo sapiens	169-172
23786711-1	2013	A series of new isoliquiritigenin (ISL) derivatives were synthesized and evaluated as dual inhibitors for amyloid-beta (Abeta) aggregation and 5-lipoxygenase (5-LO).	isoliquiritigenin	16-33	arachidonate 5-lipoxygenase	Homo sapiens	143-157
23786711-1	2013	A series of new isoliquiritigenin (ISL) derivatives were synthesized and evaluated as dual inhibitors for amyloid-beta (Abeta) aggregation and 5-lipoxygenase (5-LO).	isoliquiritigenin	35-38	arachidonate 5-lipoxygenase	Homo sapiens	143-157
23861918-0	2013	Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway.	isoliquiritigenin	17-34	vascular endothelial growth factor A	Homo sapiens	78-82
23756052-0	2013	Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus.	isoliquiritigenin	16-33	proopiomelanocortin	Homo sapiens	93-113
23861918-0	2013	Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway.	isoliquiritigenin	17-34	kinase insert domain receptor	Homo sapiens	83-90
23861918-9	2013	In vivo studies further showed that ISL administration could inhibit breast cancer growth and neoangiogenesis accompanying with suppressed VEGF/VEGFR-2 signaling, elevated apoptosis ratio and little toxicity effects.	isoliquiritigenin	36-39	vascular endothelial growth factor A	Homo sapiens	139-143
23861918-9	2013	In vivo studies further showed that ISL administration could inhibit breast cancer growth and neoangiogenesis accompanying with suppressed VEGF/VEGFR-2 signaling, elevated apoptosis ratio and little toxicity effects.	isoliquiritigenin	36-39	kinase insert domain receptor	Homo sapiens	144-151
23596884-7	2013	RT-PCR was used for determining the effect of TFGR and isoliquiritigenins on intracellular inducible nitric oxide synthase iNOS, COX-2, IL-6 and PPAR-gamma.	isoliquiritigenin	55-73	nitric oxide synthase 2	Homo sapiens	123-127
23237733-4	2013	The results showed that 100muM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%, respectively.	isoliquiritigenin	34-51	UDP glucuronosyltransferase family 1 member A7	Homo sapiens	102-108
23237733-4	2013	The results showed that 100muM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%, respectively.	isoliquiritigenin	34-51	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	110-116
23237733-4	2013	The results showed that 100muM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%, respectively.	isoliquiritigenin	34-51	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	118-124
23237733-4	2013	The results showed that 100muM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%, respectively.	isoliquiritigenin	34-51	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	130-137
23237733-6	2013	All these results indicated the risk of clinical application of isoliquiritigenin on the drug-drug interaction and other possible diseases induced by the inhibition of isoliquiritigenin towards these UGT isoforms.	isoliquiritigenin	64-81	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	200-203
23237733-6	2013	All these results indicated the risk of clinical application of isoliquiritigenin on the drug-drug interaction and other possible diseases induced by the inhibition of isoliquiritigenin towards these UGT isoforms.	isoliquiritigenin	168-185	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	200-203
23237733-0	2013	Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation.	isoliquiritigenin	0-17	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	68-95
23237733-0	2013	Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation.	isoliquiritigenin	0-17	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	97-100
23237733-1	2013	Isoliquiritigenin, a herbal ingredient with chalcone structure, has been speculated to be able to inhibit one of the most drug-metabolizing enzymes (DMEs) UDP-glucuronosyltransferase (UGT).	isoliquiritigenin	0-17	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	155-182
23237733-1	2013	Isoliquiritigenin, a herbal ingredient with chalcone structure, has been speculated to be able to inhibit one of the most drug-metabolizing enzymes (DMEs) UDP-glucuronosyltransferase (UGT).	isoliquiritigenin	0-17	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	184-187
23237733-2	2013	Therefore, the aim of the present study was to investigate the inhibition of isoliquiritigenin towards important UGT isoforms in the liver and intestine, including UGT1A1, 1A3, 1A6, 1A7, 1A8, 1A9 and 1A10.	isoliquiritigenin	77-94	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	113-116
23237733-2	2013	Therefore, the aim of the present study was to investigate the inhibition of isoliquiritigenin towards important UGT isoforms in the liver and intestine, including UGT1A1, 1A3, 1A6, 1A7, 1A8, 1A9 and 1A10.	isoliquiritigenin	77-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	164-170
23237733-4	2013	The results showed that 100muM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%, respectively.	isoliquiritigenin	34-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	78-84
23237733-4	2013	The results showed that 100muM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%, respectively.	isoliquiritigenin	34-51	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	86-92
23237733-4	2013	The results showed that 100muM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%, respectively.	isoliquiritigenin	34-51	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	94-100
23596884-8	2013	Western blot was used for detecting the effect of TFGR and isoliquiritigenins on iNOS, COX-2 and MAPK signal transduction pathways.	isoliquiritigenin	59-77	nitric oxide synthase 2	Homo sapiens	81-85
23596884-8	2013	Western blot was used for detecting the effect of TFGR and isoliquiritigenins on iNOS, COX-2 and MAPK signal transduction pathways.	isoliquiritigenin	59-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	isoliquiritigenin	0-17	nitric oxide synthase 2	Homo sapiens	56-60
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	isoliquiritigenin	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	isoliquiritigenin	0-17	interleukin 1 beta	Homo sapiens	120-128
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	isoliquiritigenin	0-17	interleukin 6	Homo sapiens	133-137
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	isoliquiritigenin	0-17	peroxisome proliferator activated receptor gamma	Homo sapiens	179-189
22995316-6	2012	Microarray analysis showed that ISL-treated LCLs represented gene expression changes in cell cycle and p53 signaling pathway, having a potential as regulators in LCL survival and sensitivity to ISL-induced cytotoxicity.	isoliquiritigenin	32-35	tumor protein p53	Homo sapiens	103-106
22807119-9	2012	The regulatory role of JNK1 in PTP1B induction by a decrease in miR-122 level was strengthened by cell-based assays using isoliquiritigenin and liquiritigenin (components in Glycyrrhizae radix) as functional JNK inhibitors; JNK inhibition enabled cells to restore IR and IRS1/2 tyrosine phosphorylation and insulin signaling against tumor necrosis factor alpha, and prevented PTP1B induction.	isoliquiritigenin	122-139	mitogen-activated protein kinase 8	Mus musculus	23-26
22807119-9	2012	The regulatory role of JNK1 in PTP1B induction by a decrease in miR-122 level was strengthened by cell-based assays using isoliquiritigenin and liquiritigenin (components in Glycyrrhizae radix) as functional JNK inhibitors; JNK inhibition enabled cells to restore IR and IRS1/2 tyrosine phosphorylation and insulin signaling against tumor necrosis factor alpha, and prevented PTP1B induction.	isoliquiritigenin	122-139	mitogen-activated protein kinase 8	Mus musculus	23-27
22807119-9	2012	The regulatory role of JNK1 in PTP1B induction by a decrease in miR-122 level was strengthened by cell-based assays using isoliquiritigenin and liquiritigenin (components in Glycyrrhizae radix) as functional JNK inhibitors; JNK inhibition enabled cells to restore IR and IRS1/2 tyrosine phosphorylation and insulin signaling against tumor necrosis factor alpha, and prevented PTP1B induction.	isoliquiritigenin	122-139	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	31-36
22807119-9	2012	The regulatory role of JNK1 in PTP1B induction by a decrease in miR-122 level was strengthened by cell-based assays using isoliquiritigenin and liquiritigenin (components in Glycyrrhizae radix) as functional JNK inhibitors; JNK inhibition enabled cells to restore IR and IRS1/2 tyrosine phosphorylation and insulin signaling against tumor necrosis factor alpha, and prevented PTP1B induction.	isoliquiritigenin	122-139	microRNA 122	Mus musculus	64-71
22648519-0	2012	Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling.	isoliquiritigenin	0-17	interleukin 6	Homo sapiens	71-75
22648519-6	2012	Taken together, our findings suggested that ISL could inhibit the growth of MM via blocking IL-6 signaling and might serve as a promising therapeutic agent for treatment of MM.	isoliquiritigenin	44-47	interleukin 6	Homo sapiens	92-96
22422925-0	2012	Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner.	isoliquiritigenin	17-34	lymphocyte antigen 96	Mus musculus	80-84
22521613-3	2012	In the present study, we investigated the effects of isoliquiritigenin (ISL), a natural flavonoid isolated from licorice, on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced in vitro osteoclastogenesis and inflammation-mediated bone destruction in vivo.	isoliquiritigenin	53-70	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	125-175
22521613-3	2012	In the present study, we investigated the effects of isoliquiritigenin (ISL), a natural flavonoid isolated from licorice, on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced in vitro osteoclastogenesis and inflammation-mediated bone destruction in vivo.	isoliquiritigenin	53-70	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	177-182
22521613-3	2012	In the present study, we investigated the effects of isoliquiritigenin (ISL), a natural flavonoid isolated from licorice, on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced in vitro osteoclastogenesis and inflammation-mediated bone destruction in vivo.	isoliquiritigenin	72-75	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	125-175
22521613-3	2012	In the present study, we investigated the effects of isoliquiritigenin (ISL), a natural flavonoid isolated from licorice, on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced in vitro osteoclastogenesis and inflammation-mediated bone destruction in vivo.	isoliquiritigenin	72-75	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	177-182
22186622-10	2012	This study reveals a novel action of ISLQ as a potent CFTR inhibitor with therapeutic potential for treatment of cholera and polycystic kidney disease.	isoliquiritigenin	37-41	CF transmembrane conductance regulator	Homo sapiens	54-58
22644857-0	2012	Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Abeta(25-35)-induced neurotoxicity in cultured rat cortical neurons.	isoliquiritigenin	67-84	amyloid beta precursor protein	Rattus norvegicus	89-94
22644857-6	2012	Isoliquiritigenin (1-20 muM), isolated from GR as an active component, inhibited Abeta (25-35)-induced neuronal apoptotic death, elevation of [Ca(2+)](i), ROS generation, and the change of apoptosis-associated proteins in cultured cortical neurons, suggesting that the neuroprotective effect of GR may be, at least partly, attributable to this compound.	isoliquiritigenin	0-17	amyloid beta precursor protein	Rattus norvegicus	81-86
22644857-7	2012	These results suggest that GR and isoliquiritigenin prevent Abeta (25-35)-induced neuronal apoptotic death by interfering with the increases of [Ca(2+)](i) and ROS, and GR may have a possible therapeutic role for preventing the progression of neurodegenerative disease such as Alzheimer"s disease.	isoliquiritigenin	34-51	amyloid beta precursor protein	Rattus norvegicus	60-65
21956714-0	2012	Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells.	isoliquiritigenin	40-57	mechanistic target of rapamycin kinase	Homo sapiens	0-29
22186622-6	2012	Apical Cl(-) current analysis of T84 cell monolayers indicated that ISLQ blocked mainly the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels, but not other unidentified cAMP-dependent Cl(-) channels.	isoliquiritigenin	68-72	CF transmembrane conductance regulator	Homo sapiens	92-143
21079875-5	2011	We applied this surface modification to proteomic screening of potential tyrosinase inhibitors with a small-molecule microarray and identified 2,4,4"-trihydroxychalcone as a new small-molecule binder to tyrosinase.	isoliquiritigenin	143-168	tyrosinase	Homo sapiens	73-83
22186622-6	2012	Apical Cl(-) current analysis of T84 cell monolayers indicated that ISLQ blocked mainly the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels, but not other unidentified cAMP-dependent Cl(-) channels.	isoliquiritigenin	68-72	CF transmembrane conductance regulator	Homo sapiens	145-149
32092841-10	2012	This study reveals a novel action of ISLQ as a potent CFTR inhibitor with therapeutic potential for treatment of cholera and polycystic kidney disease.	isoliquiritigenin	37-41	CF transmembrane conductance regulator	Canis lupus familiaris	54-58
21222511-1	2011	According to the structural characteristics of isoliquiritigenin from Glycyrrhiza uralensis, a series of hydroxychalcones has been designed, synthesized and evaluated for their in vitro inhibitory activities of beta-secretase (BACE1).	isoliquiritigenin	47-64	beta-secretase 1	Homo sapiens	227-232
21079875-5	2011	We applied this surface modification to proteomic screening of potential tyrosinase inhibitors with a small-molecule microarray and identified 2,4,4"-trihydroxychalcone as a new small-molecule binder to tyrosinase.	isoliquiritigenin	143-168	tyrosinase	Homo sapiens	203-213
20701936-4	2010	Here, biochemical evidence is reported that isoliquiritigenin, one of the major ingredients derived from licorice root, inhibits LPS-induced TLR4 dimerization resulting in inhibition of nuclear factor-kappa B and interferon regulatory factor 3 activation, and cyclooxygenase-2 and inducible nitric oxide synthase expression.	isoliquiritigenin	44-61	toll like receptor 4	Homo sapiens	141-145
20840863-0	2010	Inhibition of liver X receptor-alpha-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition.	isoliquiritigenin	68-85	nuclear receptor subfamily 1, group H, member 3	Mus musculus	14-36
20840863-0	2010	Inhibition of liver X receptor-alpha-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition.	isoliquiritigenin	68-85	mitogen-activated protein kinase 8	Mus musculus	136-140
20701936-4	2010	Here, biochemical evidence is reported that isoliquiritigenin, one of the major ingredients derived from licorice root, inhibits LPS-induced TLR4 dimerization resulting in inhibition of nuclear factor-kappa B and interferon regulatory factor 3 activation, and cyclooxygenase-2 and inducible nitric oxide synthase expression.	isoliquiritigenin	44-61	interferon regulatory factor 3	Homo sapiens	213-243
20701936-4	2010	Here, biochemical evidence is reported that isoliquiritigenin, one of the major ingredients derived from licorice root, inhibits LPS-induced TLR4 dimerization resulting in inhibition of nuclear factor-kappa B and interferon regulatory factor 3 activation, and cyclooxygenase-2 and inducible nitric oxide synthase expression.	isoliquiritigenin	44-61	prostaglandin-endoperoxide synthase 2	Homo sapiens	260-276
20456427-10	2010	Isoliquiritigenin treatment (10-100 micromol/L for 24 h) markedly inhibited the proliferation of both C4-2 and LNCaP prostate cancer cells in a dose-dependent manner.	isoliquiritigenin	0-17	CDK5 regulatory subunit associated protein 1	Homo sapiens	102-106
20026081-0	2010	AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress.	isoliquiritigenin	37-54	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	0-4
20484154-0	2010	Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase.	isoliquiritigenin	122-139	mechanistic target of rapamycin kinase	Homo sapiens	0-29
20484154-0	2010	Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase.	isoliquiritigenin	122-139	mitogen-activated protein kinase 1	Homo sapiens	211-248
20026081-0	2010	AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress.	isoliquiritigenin	37-54	glycogen synthase kinase 3 beta	Homo sapiens	14-22
20026081-1	2010	Isoliquiritigenin (ILQ), a flavonoid compound originated from Glycyrrhiza species, is known to activate SIRT1.	isoliquiritigenin	0-17	sirtuin 1	Homo sapiens	104-109
20026081-1	2010	Isoliquiritigenin (ILQ), a flavonoid compound originated from Glycyrrhiza species, is known to activate SIRT1.	isoliquiritigenin	19-22	sirtuin 1	Homo sapiens	104-109
20146476-11	2010	HG induced SMAD4 expression of HRMC and obliterated antagonistic SMAD7, whereas isoliquiritigenin suppressed induction of TGF-beta RII and TGF-beta RI with blunting their downstream SMAD signaling.	isoliquiritigenin	80-97	transforming growth factor beta receptor 2	Homo sapiens	122-134
20356041-0	2010	Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1.	isoliquiritigenin	0-17	TIR domain containing adaptor molecule 1	Homo sapiens	113-117
20356041-0	2010	Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1.	isoliquiritigenin	0-17	TANK binding kinase 1	Homo sapiens	183-187
20033868-0	2010	The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line.	isoliquiritigenin	23-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-90
20033868-3	2010	Isoliquiritigenin (ILN), a flavonoid isolated from licorice (the rhizomes of GLYCYRRHIZA GLABRA, a member of the bean plant family), is known to be a potential suppressor of COX-2 expression.	isoliquiritigenin	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
20356041-4	2010	To evaluate the therapeutic potential of isoliquiritigenin (ILG), we examined its effect on signal transduction via the TRIF-dependent pathway of TLRs.	isoliquiritigenin	41-58	TIR domain containing adaptor molecule 1	Homo sapiens	120-124
20146476-0	2010	Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation.	isoliquiritigenin	0-17	transforming growth factor beta 1	Homo sapiens	38-47
20146476-11	2010	HG induced SMAD4 expression of HRMC and obliterated antagonistic SMAD7, whereas isoliquiritigenin suppressed induction of TGF-beta RII and TGF-beta RI with blunting their downstream SMAD signaling.	isoliquiritigenin	80-97	transforming growth factor beta receptor 1	Homo sapiens	122-133
20146476-0	2010	Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation.	isoliquiritigenin	0-17	SMAD family member 4	Homo sapiens	48-52
20146476-12	2010	The results demonstrate that the bioactive isoliquiritigenin in licorice diminished mesangial matrix accumulation in response to ambient HG through retarding TGF-beta1-SMAD signaling transduction.	isoliquiritigenin	43-60	transforming growth factor beta 1	Homo sapiens	158-167
20146476-5	2010	The present study was to investigate whether nontoxic isoliquiritigenin inhibited high glucose (HG)-induced mesangial fibrosis by retarding formation of type IV collagen as well as CTGF in human mesangial cells (HRMC).	isoliquiritigenin	54-71	cellular communication network factor 2	Homo sapiens	181-185
20146476-12	2010	The results demonstrate that the bioactive isoliquiritigenin in licorice diminished mesangial matrix accumulation in response to ambient HG through retarding TGF-beta1-SMAD signaling transduction.	isoliquiritigenin	43-60	SMAD family member 4	Homo sapiens	168-172
20146476-7	2010	Exposure of cells to HG caused marked increases in collagen secretion and CTGF expression, which was dose-dependently reversed by isoliquiritigenin at the transcriptional levels.	isoliquiritigenin	130-147	cellular communication network factor 2	Homo sapiens	74-78
18824345-0	2009	Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling.	isoliquiritigenin	0-17	mitogen-activated protein kinase 8	Homo sapiens	108-111
20146476-8	2010	Additionally, isoliquiritigenin boosted HG-plummeted type matrix metalloproteinase-1 (MT-1 MMP) expression and dampened HG-elevated tissue inhibitor of MMP-2 (TIMP-2) expression, facilitating the degradation of mesangial matrix.	isoliquiritigenin	14-31	matrix metallopeptidase 14	Homo sapiens	86-94
20146476-8	2010	Additionally, isoliquiritigenin boosted HG-plummeted type matrix metalloproteinase-1 (MT-1 MMP) expression and dampened HG-elevated tissue inhibitor of MMP-2 (TIMP-2) expression, facilitating the degradation of mesangial matrix.	isoliquiritigenin	14-31	TIMP metallopeptidase inhibitor 2	Homo sapiens	132-157
20146476-8	2010	Additionally, isoliquiritigenin boosted HG-plummeted type matrix metalloproteinase-1 (MT-1 MMP) expression and dampened HG-elevated tissue inhibitor of MMP-2 (TIMP-2) expression, facilitating the degradation of mesangial matrix.	isoliquiritigenin	14-31	TIMP metallopeptidase inhibitor 2	Homo sapiens	159-165
20146476-9	2010	Isoliquiritigenin inhibited HG-upregulated CTGF and TIMP-2 expression via disturbing TGF-beta1 signaling in HRMC, as evidenced by TGF-beta receptor I kinase (TGF-beta RI) inhibitor.	isoliquiritigenin	0-17	cellular communication network factor 2	Homo sapiens	43-47
20146476-9	2010	Isoliquiritigenin inhibited HG-upregulated CTGF and TIMP-2 expression via disturbing TGF-beta1 signaling in HRMC, as evidenced by TGF-beta receptor I kinase (TGF-beta RI) inhibitor.	isoliquiritigenin	0-17	TIMP metallopeptidase inhibitor 2	Homo sapiens	52-58
20146476-9	2010	Isoliquiritigenin inhibited HG-upregulated CTGF and TIMP-2 expression via disturbing TGF-beta1 signaling in HRMC, as evidenced by TGF-beta receptor I kinase (TGF-beta RI) inhibitor.	isoliquiritigenin	0-17	transforming growth factor beta 1	Homo sapiens	85-94
20146476-9	2010	Isoliquiritigenin inhibited HG-upregulated CTGF and TIMP-2 expression via disturbing TGF-beta1 signaling in HRMC, as evidenced by TGF-beta receptor I kinase (TGF-beta RI) inhibitor.	isoliquiritigenin	0-17	transforming growth factor beta receptor 1	Homo sapiens	130-156
20146476-9	2010	Isoliquiritigenin inhibited HG-upregulated CTGF and TIMP-2 expression via disturbing TGF-beta1 signaling in HRMC, as evidenced by TGF-beta receptor I kinase (TGF-beta RI) inhibitor.	isoliquiritigenin	0-17	transforming growth factor beta receptor 1	Homo sapiens	158-169
20146476-10	2010	HG-activated SMAD2 through autocrine TGF-beta signaling was repealed by > or =10 microM isoliquiritigenin.	isoliquiritigenin	91-108	SMAD family member 2	Homo sapiens	13-18
20146476-10	2010	HG-activated SMAD2 through autocrine TGF-beta signaling was repealed by > or =10 microM isoliquiritigenin.	isoliquiritigenin	91-108	transforming growth factor beta 1	Homo sapiens	37-45
19809799-0	2009	Suppression of the TRIF-dependent signaling pathway of toll-like receptors by isoliquiritigenin in RAW264.7 macrophages.	isoliquiritigenin	78-95	TIR domain containing adaptor molecule 1	Homo sapiens	19-23
20068129-1	2010	Isoliquiritigenin (2",4",4-trihydroxychalcone; ILG), a chalcone found in licorice root and many other plants, has shown potential chemopreventive activity through induction of phase II enzymes such as quinone reductase-1 in murine hepatoma cells.	isoliquiritigenin	0-17	NAD(P)H dehydrogenase, quinone 1	Mus musculus	201-220
20068129-1	2010	Isoliquiritigenin (2",4",4-trihydroxychalcone; ILG), a chalcone found in licorice root and many other plants, has shown potential chemopreventive activity through induction of phase II enzymes such as quinone reductase-1 in murine hepatoma cells.	isoliquiritigenin	19-45	NAD(P)H dehydrogenase, quinone 1	Mus musculus	201-220
18653743-6	2008	UGT1A1 and UGT1A10 converted isoliquiritigenin to the next most abundant phase 2 metabolite, isoliquiritigenin 2"-O-glucuronide (MG4), with Km values of 2.98+/-0.8 and 25.8+/-1.3 microM, respectively.	isoliquiritigenin	29-46	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
19065667-5	2009	In the present study the licorice flavonoid isoliquiritigenin (ILN) was shown to be an aromatase inhibitor in recombinant protein and MCF-7 cells stably transfected with CYP19 (MCF-7aro).	isoliquiritigenin	44-61	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	170-175
19065667-5	2009	In the present study the licorice flavonoid isoliquiritigenin (ILN) was shown to be an aromatase inhibitor in recombinant protein and MCF-7 cells stably transfected with CYP19 (MCF-7aro).	isoliquiritigenin	63-66	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	170-175
19536869-0	2009	Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells.	isoliquiritigenin	33-50	ATM serine/threonine kinase	Homo sapiens	129-132
19536869-0	2009	Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells.	isoliquiritigenin	33-50	tumor protein p53	Homo sapiens	133-136
19132888-11	2009	Liquiritigenin, isoliquiritigenin, and 7,4"-dihydroxyflavone were more effective than liquiritin, isoononin, and glycyrrhizin in suppressing eotaxin secretion.	isoliquiritigenin	16-33	C-C motif chemokine ligand 11	Homo sapiens	141-148
19132888-12	2009	A concentration-response study showed the IC(50) concentrations of liquiritigenin, isoliquiritigenin, and 7,4"-dihydroxyflavone were 4.2, 0.92, and 0.21 microg/mL, respectively, demonstrating that Glycyrrhiza flavonoids inhibit eotaxin-1 secretion in vitro.	isoliquiritigenin	83-100	C-C motif chemokine ligand 11	Homo sapiens	228-237
19133826-6	2008	We identified three drug enhancers of migration, two of which, Papaverine and Isoliquiritigenin, specifically enhance the kit(ts) migration defect, while 8-DPAT affected both melanocyte migration and survival.	isoliquiritigenin	78-95	KIT proto-oncogene, receptor tyrosine kinase a	Danio rerio	122-125
18653743-6	2008	UGT1A1 and UGT1A10 converted isoliquiritigenin to the next most abundant phase 2 metabolite, isoliquiritigenin 2"-O-glucuronide (MG4), with Km values of 2.98+/-0.8 and 25.8+/-1.3 microM, respectively.	isoliquiritigenin	29-46	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	11-18
19568915-4	2008	Here, we show for the first time that isoliquiritigenin overcomes TRAIL resistance in colon cancer HT29 cells.	isoliquiritigenin	38-55	TNF superfamily member 10	Homo sapiens	66-71
19568915-10	2008	Furthermore, the apoptosis induced by isoliquiritigenin and TRAIL was blocked by a dominant negative form of the TRAIL receptor.	isoliquiritigenin	38-55	TNF superfamily member 10	Homo sapiens	113-118
19568915-12	2008	Isoliquiritigenin increased the amount of DR5 protein among TRAIL receptors.	isoliquiritigenin	0-17	TNF receptor superfamily member 10b	Homo sapiens	42-45
19568915-12	2008	Isoliquiritigenin increased the amount of DR5 protein among TRAIL receptors.	isoliquiritigenin	0-17	TNF superfamily member 10	Homo sapiens	60-65
19568915-14	2008	CONCLUSIONS: Our results suggest that isoliquiritigenin has the potential to overcome resistance to TRAIL in cancer cells and its chemopreventive effects may depend on TRAIL function.	isoliquiritigenin	38-55	TNF superfamily member 10	Homo sapiens	100-105
19568915-14	2008	CONCLUSIONS: Our results suggest that isoliquiritigenin has the potential to overcome resistance to TRAIL in cancer cells and its chemopreventive effects may depend on TRAIL function.	isoliquiritigenin	38-55	TNF superfamily member 10	Homo sapiens	168-173
18495107-7	2008	Inhibition of dopamine release by isoliquiritigenin resulted in attenuation of the expression of c-Fos, an immediately early gene induced by cocaine.	isoliquiritigenin	34-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-102
18462716-7	2008	Isoliquiritigenin significantly increased intracellular cGMP level in cultured TSMCs and inhibited the activity of phosphodiesterase (PDE) 5 in human platelets.	isoliquiritigenin	0-17	phosphodiesterase 5A	Homo sapiens	134-140
18439428-12	2008	Components of rikkunshito, 3,3",4",5,6,7,8-heptamethoxyflavone, hesperidin, and iso-liquiritigenin showed a 5-HT2B-antagonistic effect in vitro, and oral administration of rikkunshito suppressed the cisplatin-induced decrease in the plasma acylated-ghrelin level.	isoliquiritigenin	80-98	5-hydroxytryptamine receptor 2B	Rattus norvegicus	108-114
18439428-12	2008	Components of rikkunshito, 3,3",4",5,6,7,8-heptamethoxyflavone, hesperidin, and iso-liquiritigenin showed a 5-HT2B-antagonistic effect in vitro, and oral administration of rikkunshito suppressed the cisplatin-induced decrease in the plasma acylated-ghrelin level.	isoliquiritigenin	80-98	ghrelin and obestatin prepropeptide	Rattus norvegicus	249-256
17276410-0	2007	Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	79-88
18295200-0	2008	Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages.	isoliquiritigenin	0-17	nitric oxide synthase 2, inducible	Mus musculus	88-92
18295200-0	2008	Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages.	isoliquiritigenin	0-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-146
18563666-1	2008	We evaluated whether the antiproliferative effects of isoliquiritigenin (ISL) on rat hepatic stellate cells (HSCs) are related to the induction of heme oxygenase 1 (HO-1) expression.	isoliquiritigenin	54-71	heme oxygenase 1	Rattus norvegicus	147-163
18563666-1	2008	We evaluated whether the antiproliferative effects of isoliquiritigenin (ISL) on rat hepatic stellate cells (HSCs) are related to the induction of heme oxygenase 1 (HO-1) expression.	isoliquiritigenin	54-71	heme oxygenase 1	Rattus norvegicus	165-169
18563666-1	2008	We evaluated whether the antiproliferative effects of isoliquiritigenin (ISL) on rat hepatic stellate cells (HSCs) are related to the induction of heme oxygenase 1 (HO-1) expression.	isoliquiritigenin	73-76	heme oxygenase 1	Rattus norvegicus	147-163
18563666-1	2008	We evaluated whether the antiproliferative effects of isoliquiritigenin (ISL) on rat hepatic stellate cells (HSCs) are related to the induction of heme oxygenase 1 (HO-1) expression.	isoliquiritigenin	73-76	heme oxygenase 1	Rattus norvegicus	165-169
17259331-5	2007	At nontoxic > or =10 microM, isoliquiritigenin blocked the induction of VCAM-1 and E-selectin on activated HUVEC and markedly interfered with THP-1 monocyte adhesion to TNF-alpha-activated endothelial cells.	isoliquiritigenin	32-49	vascular cell adhesion molecule 1	Homo sapiens	75-81
17259331-5	2007	At nontoxic > or =10 microM, isoliquiritigenin blocked the induction of VCAM-1 and E-selectin on activated HUVEC and markedly interfered with THP-1 monocyte adhesion to TNF-alpha-activated endothelial cells.	isoliquiritigenin	32-49	selectin E	Homo sapiens	86-96
17259331-5	2007	At nontoxic > or =10 microM, isoliquiritigenin blocked the induction of VCAM-1 and E-selectin on activated HUVEC and markedly interfered with THP-1 monocyte adhesion to TNF-alpha-activated endothelial cells.	isoliquiritigenin	32-49	GLI family zinc finger 2	Homo sapiens	145-150
17259331-5	2007	At nontoxic > or =10 microM, isoliquiritigenin blocked the induction of VCAM-1 and E-selectin on activated HUVEC and markedly interfered with THP-1 monocyte adhesion to TNF-alpha-activated endothelial cells.	isoliquiritigenin	32-49	tumor necrosis factor	Homo sapiens	172-181
17259331-6	2007	Isoliquiritigenin abolished TNF-alpha-induced mRNA accumulation of VCAM-1 and E-selectin.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	28-37
17259331-6	2007	Isoliquiritigenin abolished TNF-alpha-induced mRNA accumulation of VCAM-1 and E-selectin.	isoliquiritigenin	0-17	vascular cell adhesion molecule 1	Homo sapiens	67-73
17259331-6	2007	Isoliquiritigenin abolished TNF-alpha-induced mRNA accumulation of VCAM-1 and E-selectin.	isoliquiritigenin	0-17	selectin E	Homo sapiens	78-88
17259331-7	2007	Additionally, immunocytochemical staining revealed that isoliquiritigenin attenuated PECAM-1 expression induced by TNF-alpha.	isoliquiritigenin	56-73	platelet and endothelial cell adhesion molecule 1	Homo sapiens	85-92
17259331-7	2007	Additionally, immunocytochemical staining revealed that isoliquiritigenin attenuated PECAM-1 expression induced by TNF-alpha.	isoliquiritigenin	56-73	tumor necrosis factor	Homo sapiens	115-124
17259331-9	2007	Isoliquiritigenin downregulated CAM proteins in TNF-alpha-activated HUVEC at the transcriptional levels by blocking degradation of IkappaBalpha and nuclear translocation of NF-kappaB.	isoliquiritigenin	0-17	tumor necrosis factor	Homo sapiens	48-57
17259331-9	2007	Isoliquiritigenin downregulated CAM proteins in TNF-alpha-activated HUVEC at the transcriptional levels by blocking degradation of IkappaBalpha and nuclear translocation of NF-kappaB.	isoliquiritigenin	0-17	NFKB inhibitor alpha	Homo sapiens	131-143
17259331-9	2007	Isoliquiritigenin downregulated CAM proteins in TNF-alpha-activated HUVEC at the transcriptional levels by blocking degradation of IkappaBalpha and nuclear translocation of NF-kappaB.	isoliquiritigenin	0-17	nuclear factor kappa B subunit 1	Homo sapiens	173-182
17259331-10	2007	These results demonstrate that the induction blockade of VCAM-1 and E-selectin by isoliquiritigenin was directly mediated by its interference with the CAM mRNA transcription through NF-kappaB-dependent mechanisms under inflammatory conditions.	isoliquiritigenin	82-99	vascular cell adhesion molecule 1	Homo sapiens	57-63
17259331-10	2007	These results demonstrate that the induction blockade of VCAM-1 and E-selectin by isoliquiritigenin was directly mediated by its interference with the CAM mRNA transcription through NF-kappaB-dependent mechanisms under inflammatory conditions.	isoliquiritigenin	82-99	selectin E	Homo sapiens	68-78
17259331-10	2007	These results demonstrate that the induction blockade of VCAM-1 and E-selectin by isoliquiritigenin was directly mediated by its interference with the CAM mRNA transcription through NF-kappaB-dependent mechanisms under inflammatory conditions.	isoliquiritigenin	82-99	nuclear factor kappa B subunit 1	Homo sapiens	182-191
16517140-7	2006	Isoliquiritigenin induced the release of cytochrome c and Smac/Diablo from the mitochondria into the cytoplasm (P<.05).	isoliquiritigenin	0-17	cytochrome c, somatic	Homo sapiens	41-53
17049118-0	2006	Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation.	isoliquiritigenin	45-62	Janus kinase 2	Rattus norvegicus	100-104
17049118-0	2006	Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation.	isoliquiritigenin	45-62	signal transducer and activator of transcription 3	Rattus norvegicus	105-110
17049118-1	2006	AIM: To examine whether isoliquiritigenin (ISL) can attenuate myocardial ischemiareperfusion (MI/R) injury in rats by inducing metallothionein (MT) through activation of janus kinase 2 (JAK 2)/signal transducers and activators of transcription 3 (STAT 3) pathway.	isoliquiritigenin	24-41	Janus kinase 2	Rattus norvegicus	170-184
17049118-1	2006	AIM: To examine whether isoliquiritigenin (ISL) can attenuate myocardial ischemiareperfusion (MI/R) injury in rats by inducing metallothionein (MT) through activation of janus kinase 2 (JAK 2)/signal transducers and activators of transcription 3 (STAT 3) pathway.	isoliquiritigenin	24-41	Janus kinase 2	Rattus norvegicus	186-191
17049118-1	2006	AIM: To examine whether isoliquiritigenin (ISL) can attenuate myocardial ischemiareperfusion (MI/R) injury in rats by inducing metallothionein (MT) through activation of janus kinase 2 (JAK 2)/signal transducers and activators of transcription 3 (STAT 3) pathway.	isoliquiritigenin	43-46	Janus kinase 2	Rattus norvegicus	170-184
16517140-8	2006	Isoliquiritigenin dose-dependently increased the levels of cleaved caspase-9, caspase-7, caspase-3 and poly(ADP-ribose) polymerase (P<.05).	isoliquiritigenin	0-17	caspase 7	Homo sapiens	78-87
16517140-8	2006	Isoliquiritigenin dose-dependently increased the levels of cleaved caspase-9, caspase-7, caspase-3 and poly(ADP-ribose) polymerase (P<.05).	isoliquiritigenin	0-17	caspase 3	Homo sapiens	89-98
16517140-7	2006	Isoliquiritigenin induced the release of cytochrome c and Smac/Diablo from the mitochondria into the cytoplasm (P<.05).	isoliquiritigenin	0-17	diablo IAP-binding mitochondrial protein	Homo sapiens	58-62
16517140-8	2006	Isoliquiritigenin dose-dependently increased the levels of cleaved caspase-9, caspase-7, caspase-3 and poly(ADP-ribose) polymerase (P<.05).	isoliquiritigenin	0-17	poly(ADP-ribose) polymerase 1	Homo sapiens	103-130
16517140-7	2006	Isoliquiritigenin induced the release of cytochrome c and Smac/Diablo from the mitochondria into the cytoplasm (P<.05).	isoliquiritigenin	0-17	diablo IAP-binding mitochondrial protein	Homo sapiens	63-69
16517140-8	2006	Isoliquiritigenin dose-dependently increased the levels of cleaved caspase-9, caspase-7, caspase-3 and poly(ADP-ribose) polymerase (P<.05).	isoliquiritigenin	0-17	caspase 9	Homo sapiens	67-76
16562858-5	2006	One of them, isoliquiritigenin (1), isolated from tonka bean, was shown to be a monofunctional inducer by having similar quinone reductase inducing ability in wild-type Hepa 1c1c7 cells and two mutant cell lines.	isoliquiritigenin	13-30	crystallin, zeta	Mus musculus	121-138
16675659-2	2006	In this study, isoliquiritigenin showed selective H(2) histamine receptor (H(2)R) antagonistic effect and remarkably reduced several H(2)R-mediated physiological responses.	isoliquiritigenin	15-32	histamine receptor H2	Homo sapiens	50-80
16399234-3	2006	Herbal flavonoid isoliquiritigenin (ILTG) has previously been reported to be a strong suppresser of the COX-2 pathway as well as an inducer of apoptosis.	isoliquiritigenin	17-34	prostaglandin-endoperoxide synthase 2	Mus musculus	104-109
12706007-5	2003	Further, we investigated the effects of isoliquiritigenin on the GADD153 mRNA and protein expression, and promoter activity.	isoliquiritigenin	40-57	DNA damage inducible transcript 3	Homo sapiens	65-72
16399234-0	2006	Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells.	isoliquiritigenin	72-89	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
17473376-0	2006	Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells.	isoliquiritigenin	0-17	erb-b2 receptor tyrosine kinase 3	Homo sapiens	33-38
17473376-0	2006	Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells.	isoliquiritigenin	19-22	erb-b2 receptor tyrosine kinase 3	Homo sapiens	33-38
15878356-0	2005	Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells.	isoliquiritigenin	0-17	tumor protein p53	Homo sapiens	66-69
15132774-0	2004	Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development.	isoliquiritigenin	0-17	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	68-87
15050731-0	2004	Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin.	isoliquiritigenin	91-108	cyclin dependent kinase inhibitor 1A	Homo sapiens	35-38
15050731-0	2004	Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin.	isoliquiritigenin	91-108	cyclin dependent kinase inhibitor 1A	Homo sapiens	39-43
15050731-0	2004	Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin.	isoliquiritigenin	91-108	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-48
15050731-5	2004	Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21(CIP1/WAF1), a universal inhibitor of cyclin-dependent kinases.	isoliquiritigenin	87-104	cyclin dependent kinase inhibitor 1A	Homo sapiens	132-135
15050731-5	2004	Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21(CIP1/WAF1), a universal inhibitor of cyclin-dependent kinases.	isoliquiritigenin	87-104	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-140
15050731-5	2004	Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21(CIP1/WAF1), a universal inhibitor of cyclin-dependent kinases.	isoliquiritigenin	87-104	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-145
12706007-8	2003	Isoliquiritigenin enhanced the expression of GADD153 mRNA and protein associated with cell cycle arrest.	isoliquiritigenin	0-17	DNA damage inducible transcript 3	Homo sapiens	45-52
12706007-9	2003	Further, isoliquiritigenin stimulated transcriptional activity of GADD153 promoter dose-dependently.	isoliquiritigenin	9-26	DNA damage inducible transcript 3	Homo sapiens	66-73
12706007-10	2003	CONCLUSION: These findings suggest that isoliquiritigenin is a candidate agent for the treatment of prostate cancer and GADD153 may play an important role in isoliquiritigenin-induced cell cycle arrest and cell growth inhibition.	isoliquiritigenin	158-175	DNA damage inducible transcript 3	Homo sapiens	120-127
12590456-8	2003	The effects of glabrene and isoliquiritigenin on tyrosinase activity were dose-dependent and correlated to their ability to inhibit melanin formation in melanocytes.	isoliquiritigenin	28-45	tyrosinase	Homo sapiens	49-59
12590456-9	2003	This is the first study indicating that glabrene and isoliquiritigenin exert varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, suggesting that isoflavenes and chalcones may serve as candidates for skin-lightening agents.	isoliquiritigenin	53-70	tyrosinase	Homo sapiens	110-120
12590456-0	2003	Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots.	isoliquiritigenin	13-30	tyrosinase	Homo sapiens	34-44
11301853-3	2001	Sanguinarine chloride (5) and isoliquiritigenin (13) were capable of lowering the levels of both ICAM-1 and VCAM-1.	isoliquiritigenin	30-47	intercellular adhesion molecule 1	Mus musculus	97-103
12590456-6	2003	Results indicated that glabrene and isoliquiritigenin (2",4",4-trihydroxychalcone) in the licorice extract can inhibit both mono- and diphenolase tyrosinase activities.	isoliquiritigenin	36-53	tyrosinase	Homo sapiens	146-156
12590456-6	2003	Results indicated that glabrene and isoliquiritigenin (2",4",4-trihydroxychalcone) in the licorice extract can inhibit both mono- and diphenolase tyrosinase activities.	isoliquiritigenin	55-81	tyrosinase	Homo sapiens	146-156
12589938-2	2002	The chalcone isoliquiritigenin (ISL) is a component of licorice extract exhibiting either antitumorigenic activity or estrogen receptor (ER) alpha-dependent growth promoting effects on breast cancer cells.	isoliquiritigenin	32-35	estrogen receptor 1	Homo sapiens	118-146
11595510-4	2001	Results indicated that glabrene and isoliquiritigenin, (2",4",4-three hydroxy chalcone) (ILC) in the licorice extract can bind to the human ER with higher affinity (IC50, 1 and 0.5 microM) than glabridin (IC50, 5 microM).	isoliquiritigenin	36-53	estrogen receptor 1	Homo sapiens	140-142
11301853-3	2001	Sanguinarine chloride (5) and isoliquiritigenin (13) were capable of lowering the levels of both ICAM-1 and VCAM-1.	isoliquiritigenin	30-47	vascular cell adhesion molecule 1	Mus musculus	108-114
11501051-5	2000	RESULTS: Liquiritigenin and isoliquiritigenin were found to be inhibitory against both MAO A and B in a dose-dependent manner.	isoliquiritigenin	28-45	monoamine oxidase A	Rattus norvegicus	87-98
11501051-1	2000	AIM: To study the inhibition of liquiritigenin (1) and isoliquiritigenin (2) isolated from Sinofranchetia chinensis on rat monoamine oxidase A and B (MAO A and B).	isoliquiritigenin	55-72	monoamine oxidase A	Rattus norvegicus	123-148
11501051-6	2000	IC50 (95% of confidence limits) of liquiritigenin and isoliquiritigenin were 32 (26-36) and 13.9 (12.8-15.6) mumol/L for the inhibition of MAO A, and 104.6 (89.0-118.9) and 47.2 (39.5-54.5) mumol/L for that of MAO B, respectively.	isoliquiritigenin	54-71	monoamine oxidase A	Rattus norvegicus	139-144
11501051-1	2000	AIM: To study the inhibition of liquiritigenin (1) and isoliquiritigenin (2) isolated from Sinofranchetia chinensis on rat monoamine oxidase A and B (MAO A and B).	isoliquiritigenin	55-72	monoamine oxidase A	Rattus norvegicus	150-161
11501051-6	2000	IC50 (95% of confidence limits) of liquiritigenin and isoliquiritigenin were 32 (26-36) and 13.9 (12.8-15.6) mumol/L for the inhibition of MAO A, and 104.6 (89.0-118.9) and 47.2 (39.5-54.5) mumol/L for that of MAO B, respectively.	isoliquiritigenin	54-71	monoamine oxidase B	Rattus norvegicus	210-215
11501051-7	2000	Lineweaver-Burk transformation of the MAO A inhibition data indicated that the inhibition was non-competitive for both liquiritigenin and isoliquiritigenin whereas their inhibition of MAO B was of mixed type.	isoliquiritigenin	138-155	monoamine oxidase A	Rattus norvegicus	38-43
11501051-8	2000	Regarding MAO A inhibition, the Ki values of liquiritigenin and isoliquiritigenin were 31.5 mumol/L and 14.3 mumol/L, respectively.	isoliquiritigenin	64-81	monoamine oxidase A	Rattus norvegicus	10-15
11501051-9	2000	As to the inhibition of MAO B, the Ki and KI data for liquiritigenin were 164.7 and 15.2 mumol/L, and those for isoliquiritigenin were 62.2 and 9.3 mumol/L, respectively.	isoliquiritigenin	112-129	monoamine oxidase B	Rattus norvegicus	24-29
9178653-3	1997	The effect of isoliquiritigenin (100 microM) on I(Ca) was diminished by Rp-cAMPS (30 microM).	isoliquiritigenin	14-31	calmodulin 2, pseudogene 1	Rattus norvegicus	75-80
11055382-10	2000	Isoliquiritigenin did not affect Bcl-2 expression, but butein down-regulated Bcl-2 expression.	isoliquiritigenin	0-17	B cell leukemia/lymphoma 2	Mus musculus	77-82
11055382-12	2000	It was supposed that isoliquiritigenin induces apoptosis in B16 cells by a mechanism involving inhibition of glucose transmembrane transport and promotion of Bax expression.	isoliquiritigenin	21-38	BCL2-associated X protein	Mus musculus	158-161
1899810-1	1991	A topical application of a chalcone derivative, 4,2",4"-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice.	isoliquiritigenin	48-74	ornithine decarboxylase, structural 1	Mus musculus	115-138
1555643-0	1992	Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice.	isoliquiritigenin	24-41	aldo-keto reductase family 1 member B	Homo sapiens	46-62
1555643-1	1992	The mechanism was studied by which isoliquiritigenin, a new aldose reductase inhibitor purified from licorice (Glycyrrhizae radix), inhibits platelet aggregation.	isoliquiritigenin	35-52	aldo-keto reductase family 1 member B	Homo sapiens	60-76
1555643-6	1992	Isoliquiritigenin appears to be the only aldose reductase inhibitor with a significant anti-platelet action.	isoliquiritigenin	0-17	aldo-keto reductase family 1 member B	Homo sapiens	41-57
1555643-7	1992	Since the hyperaggregability of platelets has been implicated in the pathogenesis of diabetic complications, isoliquiritigenin may offer a unique benefit as an aldose reductase inhibitor.	isoliquiritigenin	109-126	aldo-keto reductase family 1 member B	Homo sapiens	160-176
9105881-3	1997	The effects developed faster with YC-1 than with isoliquiritigenin, and the effects of YC-1 were potentiated by isoliquiritigenin (10 microM).	isoliquiritigenin	112-129	glutathione S-transferase alpha 1	Rattus norvegicus	87-91
24202070-2	1993	The coaction of a reductase with chalcone synthase (CHS) has been established in soybean cells to be responsible for the synthesis of 6"-deoxychalcone.	isoliquiritigenin	134-150	chalcone reductase CHR1	Glycine max	18-27
24202070-2	1993	The coaction of a reductase with chalcone synthase (CHS) has been established in soybean cells to be responsible for the synthesis of 6"-deoxychalcone.	isoliquiritigenin	134-150	chalcone synthase	Glycine max	33-50
24202070-2	1993	The coaction of a reductase with chalcone synthase (CHS) has been established in soybean cells to be responsible for the synthesis of 6"-deoxychalcone.	isoliquiritigenin	134-150	chalcone synthase	Glycine max	52-55
24202070-6	1993	These results indicate that in G. echinata, too, synthesis of 6"-deoxychalcone is likely to be performed by the coaction of the reductase and CHS.	isoliquiritigenin	62-78	chalcone reductase CHR1	Glycine max	128-137
24202070-6	1993	These results indicate that in G. echinata, too, synthesis of 6"-deoxychalcone is likely to be performed by the coaction of the reductase and CHS.	isoliquiritigenin	62-78	chalcone synthase	Glycine max	142-145
1536573-1	1992	The cDNA for the reductase involved in the biosynthesis of 6"-deoxychalcone (4,2",4"-trihydroxychalcone), the first specific intermediate in the pathway to soybean phytoalexins, was cloned into the expression vector pKK233-2 and transformed into Escherichia coli.	isoliquiritigenin	59-75	chalcone reductase CHR1	Glycine max	17-26
1536573-1	1992	The cDNA for the reductase involved in the biosynthesis of 6"-deoxychalcone (4,2",4"-trihydroxychalcone), the first specific intermediate in the pathway to soybean phytoalexins, was cloned into the expression vector pKK233-2 and transformed into Escherichia coli.	isoliquiritigenin	77-103	chalcone reductase CHR1	Glycine max	17-26
1899810-1	1991	A topical application of a chalcone derivative, 4,2",4"-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice.	isoliquiritigenin	48-74	ornithine decarboxylase, structural 1	Mus musculus	140-143
1899810-1	1991	A topical application of a chalcone derivative, 4,2",4"-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice.	isoliquiritigenin	76-93	ornithine decarboxylase, structural 1	Mus musculus	115-138
1899810-1	1991	A topical application of a chalcone derivative, 4,2",4"-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice.	isoliquiritigenin	76-93	ornithine decarboxylase, structural 1	Mus musculus	140-143
1899810-4	1991	Isoliquiritigenin also inhibited epidermal ODC induction and skin tumor promotion caused by 7-bromomethylbenz[alpha]anthracene (BrMBA), a non-TPA type of tumor-promoting agent, in DMBA-initiated mice.	isoliquiritigenin	0-17	ornithine decarboxylase, structural 1	Mus musculus	43-46
34968927-0	2022	Isoliquiritigenin prevents Doxorubicin-induced hepatic damage in rats by upregulating and activating SIRT1.	isoliquiritigenin	0-17	sirtuin 1	Rattus norvegicus	101-106
33793806-0	2021	Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury.	isoliquiritigenin	0-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	56-60
33793806-0	2021	Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury.	isoliquiritigenin	0-17	caspase 3	Rattus norvegicus	61-70
2118267-0	1990	Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix.	isoliquiritigenin	0-17	aldo-keto reductase family 1 member B1	Rattus norvegicus	25-41
2118267-4	1990	Among these, GU-17, identified as isoliquiritigenin, had the most potent aldose reductase inhibiting activity.	isoliquiritigenin	13-18	aldo-keto reductase family 1 member B1	Rattus norvegicus	73-89
2118267-4	1990	Among these, GU-17, identified as isoliquiritigenin, had the most potent aldose reductase inhibiting activity.	isoliquiritigenin	34-51	aldo-keto reductase family 1 member B1	Rattus norvegicus	73-89
2118267-5	1990	Isoliquiritigenin inhibited rat lens aldose reductase with an IC50 of 3.2 x 10(-7) M, using DL-glyceraldehyde as a substrate.	isoliquiritigenin	0-17	aldo-keto reductase family 1 member B1	Rattus norvegicus	37-53
33799801-0	2021	Isoliquiritigenin Reverses Epithelial-Mesenchymal Transition Through Modulation of the TGF-beta/Smad Signaling Pathway in Endometrial Cancer.	isoliquiritigenin	0-17	transforming growth factor alpha	Homo sapiens	87-95
34968927-1	2022	This study evaluated if the hepatic protective effect of Isoliquiritigenin (ISL) against doxorubicin (DOX)-treated rats involves upregulating sirtuin-1 (SIRT1) signaling.	isoliquiritigenin	57-74	sirtuin 1	Rattus norvegicus	142-151
34968927-1	2022	This study evaluated if the hepatic protective effect of Isoliquiritigenin (ISL) against doxorubicin (DOX)-treated rats involves upregulating sirtuin-1 (SIRT1) signaling.	isoliquiritigenin	57-74	sirtuin 1	Rattus norvegicus	153-158
34968927-1	2022	This study evaluated if the hepatic protective effect of Isoliquiritigenin (ISL) against doxorubicin (DOX)-treated rats involves upregulating sirtuin-1 (SIRT1) signaling.	isoliquiritigenin	76-79	sirtuin 1	Rattus norvegicus	142-151
34968927-1	2022	This study evaluated if the hepatic protective effect of Isoliquiritigenin (ISL) against doxorubicin (DOX)-treated rats involves upregulating sirtuin-1 (SIRT1) signaling.	isoliquiritigenin	76-79	sirtuin 1	Rattus norvegicus	153-158
34924130-0	2022	Renoprotective effect of isoliquiritigenin on cisplatin-induced acute kidney injury through inhibition of FPR2 in macrophage.	isoliquiritigenin	25-42	formyl peptide receptor 2	Homo sapiens	106-110
34785106-0	2022	Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1alpha to alleviate alcoholic liver injury.	isoliquiritigenin	0-17	PPARG coactivator 1 alpha	Homo sapiens	59-69
34655849-11	2021	Furthermore, drug response analysis implied that AGT expression was associated with isoliquiritigenins (ISL).	isoliquiritigenin	84-102	angiotensinogen	Homo sapiens	49-52
34655849-11	2021	Furthermore, drug response analysis implied that AGT expression was associated with isoliquiritigenins (ISL).	isoliquiritigenin	104-107	angiotensinogen	Homo sapiens	49-52
34120019-2	2021	Further studies obtained the optimized isoliquiritigenin derivative SMU-B14, which can inhibit Pam3CSK4 triggered toll-like receptor 2 (TLR2) signaling with low toxicity and high potency.	isoliquiritigenin	39-56	toll like receptor 2	Homo sapiens	114-134
34794890-1	2021	OBJECTIVE: To investigate whether pyroptosis is induced by Porphyromonas gingivalis-lipopolysaccharide (P. gingivalis-LPS)/ adenosine triphosphate (ATP) through NF-kappaB/NLRP3/GSDMD signaling in human gingival fibroblasts (HGFs) and whether isoliquiritigenin (ISL) alleviates pyroptosis by inhibition of NF-kappaB/NLRP3/GSDMD signals.	isoliquiritigenin	242-259	nuclear factor kappa B subunit 1	Homo sapiens	305-314
34794890-1	2021	OBJECTIVE: To investigate whether pyroptosis is induced by Porphyromonas gingivalis-lipopolysaccharide (P. gingivalis-LPS)/ adenosine triphosphate (ATP) through NF-kappaB/NLRP3/GSDMD signaling in human gingival fibroblasts (HGFs) and whether isoliquiritigenin (ISL) alleviates pyroptosis by inhibition of NF-kappaB/NLRP3/GSDMD signals.	isoliquiritigenin	242-259	NLR family pyrin domain containing 3	Homo sapiens	315-320
34794890-1	2021	OBJECTIVE: To investigate whether pyroptosis is induced by Porphyromonas gingivalis-lipopolysaccharide (P. gingivalis-LPS)/ adenosine triphosphate (ATP) through NF-kappaB/NLRP3/GSDMD signaling in human gingival fibroblasts (HGFs) and whether isoliquiritigenin (ISL) alleviates pyroptosis by inhibition of NF-kappaB/NLRP3/GSDMD signals.	isoliquiritigenin	242-259	gasdermin D	Homo sapiens	321-326
34805144-4	2021	Moreover, according to the CMAP database, we identified isoliquiritigenin (ISL) as an agent to inhibit ITGB3.	isoliquiritigenin	56-73	cystatin F	Homo sapiens	27-31
34805144-4	2021	Moreover, according to the CMAP database, we identified isoliquiritigenin (ISL) as an agent to inhibit ITGB3.	isoliquiritigenin	56-73	integrin subunit beta 3	Homo sapiens	103-108
34805144-4	2021	Moreover, according to the CMAP database, we identified isoliquiritigenin (ISL) as an agent to inhibit ITGB3.	isoliquiritigenin	75-78	cystatin F	Homo sapiens	27-31
34805144-4	2021	Moreover, according to the CMAP database, we identified isoliquiritigenin (ISL) as an agent to inhibit ITGB3.	isoliquiritigenin	75-78	integrin subunit beta 3	Homo sapiens	103-108
34794890-0	2021	Isoliquiritigenin alleviates P. gingivalis-LPS/ATP-induced pyroptosis by inhibiting NF-kappaB/ NLRP3/GSDMD signals in human gingival fibroblasts.	isoliquiritigenin	0-17	nuclear factor kappa B subunit 1	Homo sapiens	84-93
34794890-0	2021	Isoliquiritigenin alleviates P. gingivalis-LPS/ATP-induced pyroptosis by inhibiting NF-kappaB/ NLRP3/GSDMD signals in human gingival fibroblasts.	isoliquiritigenin	0-17	NLR family pyrin domain containing 3	Homo sapiens	95-100
34794890-0	2021	Isoliquiritigenin alleviates P. gingivalis-LPS/ATP-induced pyroptosis by inhibiting NF-kappaB/ NLRP3/GSDMD signals in human gingival fibroblasts.	isoliquiritigenin	0-17	gasdermin D	Homo sapiens	101-106
34555641-0	2021	Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1alpha/ Nrf2 pathway to reduce oxidative stress and inflammatory response.	isoliquiritigenin	0-17	PPARG coactivator 1 alpha	Homo sapiens	87-97
34555641-0	2021	Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1alpha/ Nrf2 pathway to reduce oxidative stress and inflammatory response.	isoliquiritigenin	0-17	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
34120019-2	2021	Further studies obtained the optimized isoliquiritigenin derivative SMU-B14, which can inhibit Pam3CSK4 triggered toll-like receptor 2 (TLR2) signaling with low toxicity and high potency.	isoliquiritigenin	39-56	toll like receptor 2	Homo sapiens	136-140
35634373-9	2022	Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4.	isoliquiritigenin	189-206	dipeptidyl peptidase 4	Homo sapiens	82-87
35589023-0	2022	The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-kappaB and MAPK signaling pathways.	isoliquiritigenin	23-40	notch 1	Mus musculus	108-114
35589023-0	2022	The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-kappaB and MAPK signaling pathways.	isoliquiritigenin	23-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
35489326-0	2022	Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.	isoliquiritigenin	0-17	caveolin 1	Danio rerio	52-62
35489326-5	2022	HYPOTHESIS/PURPOSE: To explore the regulatory mechanism of isoliquiritigenin (ISL) in the process of liver fibrosis and the relationship between Cav-1 and ferroptosis.	isoliquiritigenin	59-76	caveolin 1	Danio rerio	145-150
35489326-5	2022	HYPOTHESIS/PURPOSE: To explore the regulatory mechanism of isoliquiritigenin (ISL) in the process of liver fibrosis and the relationship between Cav-1 and ferroptosis.	isoliquiritigenin	78-81	caveolin 1	Danio rerio	145-150
35583127-5	2022	In this study, the effect of isoliquiritigenin on AGE-induced renal proximal tubular fibrosis was determined in cultured HK-2 cell line.	isoliquiritigenin	29-46	renin binding protein	Homo sapiens	50-53
35583127-7	2022	However, treatment with 200 nM of isoliquiritigenin considerably inhibited the TEMT and suppressed the TGFbeta/STAT3 mechanism to inhibit collagen secretion.	isoliquiritigenin	34-51	transforming growth factor alpha	Homo sapiens	103-110
35583127-7	2022	However, treatment with 200 nM of isoliquiritigenin considerably inhibited the TEMT and suppressed the TGFbeta/STAT3 mechanism to inhibit collagen secretion.	isoliquiritigenin	34-51	signal transducer and activator of transcription 3	Homo sapiens	111-116
35583127-8	2022	Therefore, isoliquiritigenin effectively suppressed AGE-induced renal tubular fibrosis.	isoliquiritigenin	11-28	renin binding protein	Homo sapiens	52-55
35634373-1	2022	With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate the interaction mechanisms between them, a pannel of 70 structurally diverse flavonoids was used to evaluate their inhibitory activities against DPP-4, among which myricetin, hyperoside, narcissoside, cyanidin 3-O-glucoside, and isoliquiritigenin showed higher inhibitory activities in a concentration-dependent manner.	isoliquiritigenin	367-384	dipeptidyl peptidase 4	Homo sapiens	117-122
35634373-9	2022	Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4.	isoliquiritigenin	189-206	dipeptidyl peptidase 4	Homo sapiens	247-252
35634373-9	2022	Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4.	isoliquiritigenin	189-206	dipeptidyl peptidase 4	Homo sapiens	420-425
35082510-6	2022	Studies have shown that a variety of active components found in Glycyrrhiza, such as licochalcone A, echinatin, isoliquiritigenin, and glycyrrhizin, produce a wide range of anti-inflammatory effects by discouraging NLRP3 inflammasome activation.	isoliquiritigenin	112-129	NLR family pyrin domain containing 3	Homo sapiens	215-220
35140620-9	2022	The results of BCA indicated that Gastrodin, Liquiritin, Hesperidin, Isoliquiritin, Hesperetin, and Isoliquiritigenin might be the active constituents to activate ROS and suppress hs-CRP as determined by spectrum-effect relationships.	isoliquiritigenin	100-117	C-reactive protein	Homo sapiens	183-186
35517984-0	2022	Isoliquiritigenin Ameliorates Ischemia-Induced Myocardial Injury via Modulating the Nrf2/HO-1 Pathway in Mice.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
35517984-0	2022	Isoliquiritigenin Ameliorates Ischemia-Induced Myocardial Injury via Modulating the Nrf2/HO-1 Pathway in Mice.	isoliquiritigenin	0-17	heme oxygenase 1	Mus musculus	89-93
35517984-12	2022	However, the administration of ML385 not only suppressed the Nrf2/HO-1 activation, the anti-oxidant and anti-inflammatory effects induced by ISL, but also attenuated the beneficial role of ISL on reducing infarct size and improving cardiac function in the mouse with AMI.	isoliquiritigenin	141-144	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65
35517984-12	2022	However, the administration of ML385 not only suppressed the Nrf2/HO-1 activation, the anti-oxidant and anti-inflammatory effects induced by ISL, but also attenuated the beneficial role of ISL on reducing infarct size and improving cardiac function in the mouse with AMI.	isoliquiritigenin	141-144	heme oxygenase 1	Mus musculus	66-70
35041255-0	2022	Activation of PGC-1alpha via isoliquiritigenin-induced downregulation of miR-138-5p alleviates nonalcoholic fatty liver disease.	isoliquiritigenin	29-46	PPARG coactivator 1 alpha	Homo sapiens	14-24
35114453-0	2022	Isoliquiritigenin alleviates diabetic symptoms via activating AMPK and inhibiting mTORC1 signaling in diet-induced diabetic mice.	isoliquiritigenin	0-17	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	62-66
33404688-3	2021	In an autopatch-clamp study, isoliquiritigenin inhibited the currents of Nav1.1, Nav1.3, Nav1.6, Nav1.7, and Nav1.8 in a channel expression system.	isoliquiritigenin	29-46	sodium voltage-gated channel alpha subunit 1	Homo sapiens	73-79
35114453-0	2022	Isoliquiritigenin alleviates diabetic symptoms via activating AMPK and inhibiting mTORC1 signaling in diet-induced diabetic mice.	isoliquiritigenin	0-17	CREB regulated transcription coactivator 1	Mus musculus	82-88
2500065-0	1989	Phytoalexin synthesis in soybean cells: elicitor induction of reductase involved in biosynthesis of 6"-deoxychalcone.	isoliquiritigenin	100-116	chalcone reductase CHR1	Glycine max	62-71
2500065-1	1989	Chromatofocusing on Mono P proved to be an efficient purification procedure for the NADPH-dependent reductase from soybean (Glycine max L.) cell cultures which acts together with chalcone synthase in the biosynthesis of 2",4",4-trihydroxychalcone (6"-deoxychalcone).	isoliquiritigenin	220-246	chalcone reductase CHR1	Glycine max	100-109
2500065-1	1989	Chromatofocusing on Mono P proved to be an efficient purification procedure for the NADPH-dependent reductase from soybean (Glycine max L.) cell cultures which acts together with chalcone synthase in the biosynthesis of 2",4",4-trihydroxychalcone (6"-deoxychalcone).	isoliquiritigenin	248-264	chalcone reductase CHR1	Glycine max	100-109
2500065-3	1989	Addition of pure soybean reductase to cell-free extracts from stimulated cell cultures of parsley and bean (Phaseolus vulgaris) and from young flowers of Dahlia variabilis caused in each case synthesis of 6"-deoxychalcone.	isoliquiritigenin	205-221	chalcone reductase CHR1	Glycine max	25-34
2500065-12	1989	The results indicate a parallel induction of de novo synthesis of reductase and CHS which coact in synthesis of 6"-deoxychalcone.	isoliquiritigenin	112-128	chalcone reductase CHR1	Glycine max	66-75
2500065-12	1989	The results indicate a parallel induction of de novo synthesis of reductase and CHS which coact in synthesis of 6"-deoxychalcone.	isoliquiritigenin	112-128	chalcone synthase 3	Glycine max	80-83
33404688-3	2021	In an autopatch-clamp study, isoliquiritigenin inhibited the currents of Nav1.1, Nav1.3, Nav1.6, Nav1.7, and Nav1.8 in a channel expression system.	isoliquiritigenin	29-46	sodium voltage-gated channel alpha subunit 3	Homo sapiens	81-87
33288747-0	2020	Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism.	isoliquiritigenin	0-17	sirtuin 1	Rattus norvegicus	116-121
33404688-3	2021	In an autopatch-clamp study, isoliquiritigenin inhibited the currents of Nav1.1, Nav1.3, Nav1.6, Nav1.7, and Nav1.8 in a channel expression system.	isoliquiritigenin	29-46	sodium voltage-gated channel alpha subunit 8	Homo sapiens	89-95
33404688-3	2021	In an autopatch-clamp study, isoliquiritigenin inhibited the currents of Nav1.1, Nav1.3, Nav1.6, Nav1.7, and Nav1.8 in a channel expression system.	isoliquiritigenin	29-46	sodium voltage-gated channel alpha subunit 9	Homo sapiens	97-103
33404688-3	2021	In an autopatch-clamp study, isoliquiritigenin inhibited the currents of Nav1.1, Nav1.3, Nav1.6, Nav1.7, and Nav1.8 in a channel expression system.	isoliquiritigenin	29-46	sodium voltage-gated channel alpha subunit 10	Homo sapiens	109-115
33860590-0	2021	Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis.	isoliquiritigenin	18-35	IQ motif containing GTPase activating protein 2	Homo sapiens	94-100
33860590-0	2021	Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis.	isoliquiritigenin	18-35	cAMP responsive element binding protein 1	Homo sapiens	101-105
33860590-0	2021	Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis.	isoliquiritigenin	18-35	sirtuin 1	Homo sapiens	106-111
33860590-4	2021	ISO treatment successfully ameliorated fatty acid-induced cellular lipid accumulation and improved nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) by increasing PPARalpha-dependent lipid oxidation and decreasing SREBPs-dependent lipid synthesis.	isoliquiritigenin	0-3	peroxisome proliferator activated receptor alpha	Homo sapiens	194-203
33860590-6	2021	Knockdown of SIRT1 resulted in the reversal of ISO beneficiary effects suggesting that the lipid-lowering activity of ISO was regulated by SIRT1 expression.	isoliquiritigenin	47-50	sirtuin 1	Homo sapiens	13-18
33860590-6	2021	Knockdown of SIRT1 resulted in the reversal of ISO beneficiary effects suggesting that the lipid-lowering activity of ISO was regulated by SIRT1 expression.	isoliquiritigenin	118-121	sirtuin 1	Homo sapiens	13-18
33860590-6	2021	Knockdown of SIRT1 resulted in the reversal of ISO beneficiary effects suggesting that the lipid-lowering activity of ISO was regulated by SIRT1 expression.	isoliquiritigenin	118-121	sirtuin 1	Homo sapiens	139-144
33860590-7	2021	To identify the direct target of ISO, limited proteolysis combined with mass spectrometry (LiP-SMap) strategy was applied and IQGAP2 was identified as the direct target for ISO in regulating lipid homeostasis.	isoliquiritigenin	33-36	IQ motif containing GTPase activating protein 2	Homo sapiens	126-132
33860590-7	2021	To identify the direct target of ISO, limited proteolysis combined with mass spectrometry (LiP-SMap) strategy was applied and IQGAP2 was identified as the direct target for ISO in regulating lipid homeostasis.	isoliquiritigenin	173-176	IQ motif containing GTPase activating protein 2	Homo sapiens	126-132
33860590-8	2021	In the presence of ISO, both mRNA and protein levels of SIRT1 were increased; however, this effect was abolished by blocking IQGAP2 expression using siRNA.	isoliquiritigenin	19-22	sirtuin 1	Homo sapiens	56-61
33860590-8	2021	In the presence of ISO, both mRNA and protein levels of SIRT1 were increased; however, this effect was abolished by blocking IQGAP2 expression using siRNA.	isoliquiritigenin	19-22	IQ motif containing GTPase activating protein 2	Homo sapiens	125-131
33860590-11	2021	Thus, we not only demonstrated the molecular basis of ISO in regulating lipid metabolism but also exhibited for the first time a novel IQGAP2-CREB-SIRT1 axis in treating NAFLD/NASH.	isoliquiritigenin	54-57	IQ motif containing GTPase activating protein 2	Homo sapiens	135-141
33860590-11	2021	Thus, we not only demonstrated the molecular basis of ISO in regulating lipid metabolism but also exhibited for the first time a novel IQGAP2-CREB-SIRT1 axis in treating NAFLD/NASH.	isoliquiritigenin	54-57	cAMP responsive element binding protein 1	Homo sapiens	142-146
33860590-11	2021	Thus, we not only demonstrated the molecular basis of ISO in regulating lipid metabolism but also exhibited for the first time a novel IQGAP2-CREB-SIRT1 axis in treating NAFLD/NASH.	isoliquiritigenin	54-57	sirtuin 1	Homo sapiens	147-152
33642990-0	2021	Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-beta42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-kappaB Signaling.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-133
33642990-0	2021	Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-beta42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-kappaB Signaling.	isoliquiritigenin	0-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
33502699-0	2021	Synergistic anticancer effect of docosahexaenoic acid and isoliquiritigenin on human colorectal cancer cells through ROS-mediated regulation of the JNK and cytochrome c release.	isoliquiritigenin	58-75	mitogen-activated protein kinase 8	Homo sapiens	148-151
33502699-0	2021	Synergistic anticancer effect of docosahexaenoic acid and isoliquiritigenin on human colorectal cancer cells through ROS-mediated regulation of the JNK and cytochrome c release.	isoliquiritigenin	58-75	cytochrome c, somatic	Homo sapiens	156-168
33641651-0	2021	Isoliquiritigenin Suppresses EMT-Induced Metastasis in Triple-Negative Breast Cancer through miR-200c/C-JUN/[Formula: see text]-Catenin.	isoliquiritigenin	0-17	microRNA 200c	Homo sapiens	93-101
33641651-0	2021	Isoliquiritigenin Suppresses EMT-Induced Metastasis in Triple-Negative Breast Cancer through miR-200c/C-JUN/[Formula: see text]-Catenin.	isoliquiritigenin	0-17	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-107
32920133-13	2021	We found that Nrf2 promotes a cell antioxidant response and is a key common target in the response to treatment with isoliquiritigenin (ISL), pterostilbene (PTE) and quercetin (QUE), the highly absorbed active ingredients in the formula.	isoliquiritigenin	117-134	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
32920133-13	2021	We found that Nrf2 promotes a cell antioxidant response and is a key common target in the response to treatment with isoliquiritigenin (ISL), pterostilbene (PTE) and quercetin (QUE), the highly absorbed active ingredients in the formula.	isoliquiritigenin	136-139	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
32699958-0	2020	Isoliquiritigenin downregulates miR-195 and attenuates oxidative stress and inflammation in STZ-induced retinal injury.	isoliquiritigenin	0-17	microRNA 195	Rattus norvegicus	32-39
33271769-0	2020	Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition.	isoliquiritigenin	0-17	mitogen-activated protein kinase 8	Homo sapiens	90-93
32985258-0	2020	The effects and mechanisms of isoliquiritigenin loaded nanoliposomes regulated AMPK/mTOR mediated glycolysis in colorectal cancer.	isoliquiritigenin	30-47	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	79-83
32985258-0	2020	The effects and mechanisms of isoliquiritigenin loaded nanoliposomes regulated AMPK/mTOR mediated glycolysis in colorectal cancer.	isoliquiritigenin	30-47	mechanistic target of rapamycin kinase	Homo sapiens	84-88
32699958-7	2020	Oral administration of ISL (20 mg/kg/day) to diabetic rats for 8 weeks improved diabetes-induced retinal injury via down-regulation of miR-195, restoration of retinal SIRT-1 level, attenuation of oxidative stress, inflammation, and endothelial damage as well as preservation of retinal normal histology and ultrastructure.	isoliquiritigenin	23-26	microRNA 195	Rattus norvegicus	135-142
32699958-7	2020	Oral administration of ISL (20 mg/kg/day) to diabetic rats for 8 weeks improved diabetes-induced retinal injury via down-regulation of miR-195, restoration of retinal SIRT-1 level, attenuation of oxidative stress, inflammation, and endothelial damage as well as preservation of retinal normal histology and ultrastructure.	isoliquiritigenin	23-26	sirtuin 1	Rattus norvegicus	167-173
32328171-0	2020	Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression.	isoliquiritigenin	0-17	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	55-60
32867185-0	2020	Isoliquiritigenin Derivatives Inhibit RANKL-Induced Osteoclastogenesis by Regulating p38 and NF-kappaB Activation in RAW 264.7 Cells.	isoliquiritigenin	0-17	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	38-43
32867185-0	2020	Isoliquiritigenin Derivatives Inhibit RANKL-Induced Osteoclastogenesis by Regulating p38 and NF-kappaB Activation in RAW 264.7 Cells.	isoliquiritigenin	0-17	mitogen-activated protein kinase 14	Mus musculus	85-88
32867185-0	2020	Isoliquiritigenin Derivatives Inhibit RANKL-Induced Osteoclastogenesis by Regulating p38 and NF-kappaB Activation in RAW 264.7 Cells.	isoliquiritigenin	0-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-102
31896010-0	2020	Isoliquiritigenin triggers developmental toxicity and oxidative stress-mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway.	isoliquiritigenin	0-17	nfe2 like bZIP transcription factor 2a	Danio rerio	122-126
31896010-10	2020	The expressions pattern of apoptosis-related genes Bad, Cyto c, Caspase-9, Caspase-3 and Bax/Bcl-2 indicated that the oxidative stress-induced apoptosis triggered by ISL suggest involvement of Nrf2-HO1/JNK-ERK/mitochondrion pathways.	isoliquiritigenin	166-169	caspase 9, apoptosis-related cysteine peptidase	Danio rerio	64-73
31896010-10	2020	The expressions pattern of apoptosis-related genes Bad, Cyto c, Caspase-9, Caspase-3 and Bax/Bcl-2 indicated that the oxidative stress-induced apoptosis triggered by ISL suggest involvement of Nrf2-HO1/JNK-ERK/mitochondrion pathways.	isoliquiritigenin	166-169	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	75-84
31896010-10	2020	The expressions pattern of apoptosis-related genes Bad, Cyto c, Caspase-9, Caspase-3 and Bax/Bcl-2 indicated that the oxidative stress-induced apoptosis triggered by ISL suggest involvement of Nrf2-HO1/JNK-ERK/mitochondrion pathways.	isoliquiritigenin	166-169	BCL2 associated X, apoptosis regulator a	Danio rerio	89-92
31896010-10	2020	The expressions pattern of apoptosis-related genes Bad, Cyto c, Caspase-9, Caspase-3 and Bax/Bcl-2 indicated that the oxidative stress-induced apoptosis triggered by ISL suggest involvement of Nrf2-HO1/JNK-ERK/mitochondrion pathways.	isoliquiritigenin	166-169	BCL2 apoptosis regulator a	Danio rerio	93-98
31896010-10	2020	The expressions pattern of apoptosis-related genes Bad, Cyto c, Caspase-9, Caspase-3 and Bax/Bcl-2 indicated that the oxidative stress-induced apoptosis triggered by ISL suggest involvement of Nrf2-HO1/JNK-ERK/mitochondrion pathways.	isoliquiritigenin	166-169	nfe2 like bZIP transcription factor 2a	Danio rerio	193-197
32341639-0	2020	Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway.	isoliquiritigenin	0-17	C-type lectin domain family 4 member E	Homo sapiens	87-93
32341639-0	2020	Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway.	isoliquiritigenin	0-17	spleen associated tyrosine kinase	Homo sapiens	94-97
32341639-0	2020	Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway.	isoliquiritigenin	0-17	nuclear factor kappa B subunit 1	Homo sapiens	98-108
32726604-0	2020	Isoliquiritigenin protects against angiotensin II-induced fibrogenesis by inhibiting NF-kappaB/PPARgamma inflammatory pathway in human Tenon"s capsule fibroblasts.	isoliquiritigenin	0-17	angiotensinogen	Homo sapiens	35-49
32726604-0	2020	Isoliquiritigenin protects against angiotensin II-induced fibrogenesis by inhibiting NF-kappaB/PPARgamma inflammatory pathway in human Tenon"s capsule fibroblasts.	isoliquiritigenin	0-17	peroxisome proliferator activated receptor gamma	Homo sapiens	95-104
32726604-1	2020	PURPOSE: To examine the protective effects of Isoliquiritigenin (ISL) in angiotensin II (ANG II)-induced inflammation and fibrosis on Human Tenon"s capsule Fibroblasts (HTFs) and Mouse Peritoneal Macrophages (MPMs).	isoliquiritigenin	46-63	angiotensinogen	Homo sapiens	73-87
32726604-1	2020	PURPOSE: To examine the protective effects of Isoliquiritigenin (ISL) in angiotensin II (ANG II)-induced inflammation and fibrosis on Human Tenon"s capsule Fibroblasts (HTFs) and Mouse Peritoneal Macrophages (MPMs).	isoliquiritigenin	65-68	angiotensinogen	Homo sapiens	73-87
32726604-1	2020	PURPOSE: To examine the protective effects of Isoliquiritigenin (ISL) in angiotensin II (ANG II)-induced inflammation and fibrosis on Human Tenon"s capsule Fibroblasts (HTFs) and Mouse Peritoneal Macrophages (MPMs).	isoliquiritigenin	65-68	angiotensinogen	Homo sapiens	89-95
32726604-7	2020	RESULTS: Pre-treatment with ISL (10 or 20 muM) dose-dependently decreased the mRNA levels of TNF-alpha, IL-6, ICAM-1, and COX-2 induced by ANG II (1 mug/ml) in both MPMs and HTFs.	isoliquiritigenin	28-31	tumor necrosis factor	Homo sapiens	93-102
32726604-7	2020	RESULTS: Pre-treatment with ISL (10 or 20 muM) dose-dependently decreased the mRNA levels of TNF-alpha, IL-6, ICAM-1, and COX-2 induced by ANG II (1 mug/ml) in both MPMs and HTFs.	isoliquiritigenin	28-31	interleukin 6	Homo sapiens	104-108
32726604-7	2020	RESULTS: Pre-treatment with ISL (10 or 20 muM) dose-dependently decreased the mRNA levels of TNF-alpha, IL-6, ICAM-1, and COX-2 induced by ANG II (1 mug/ml) in both MPMs and HTFs.	isoliquiritigenin	28-31	intercellular adhesion molecule 1	Homo sapiens	110-116
32726604-7	2020	RESULTS: Pre-treatment with ISL (10 or 20 muM) dose-dependently decreased the mRNA levels of TNF-alpha, IL-6, ICAM-1, and COX-2 induced by ANG II (1 mug/ml) in both MPMs and HTFs.	isoliquiritigenin	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
32726604-7	2020	RESULTS: Pre-treatment with ISL (10 or 20 muM) dose-dependently decreased the mRNA levels of TNF-alpha, IL-6, ICAM-1, and COX-2 induced by ANG II (1 mug/ml) in both MPMs and HTFs.	isoliquiritigenin	28-31	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	139-145
32707499-0	2020	Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFkappaB balance and NLRP3 expression.	isoliquiritigenin	21-38	sirtuin 1	Rattus norvegicus	95-110
32707499-0	2020	Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFkappaB balance and NLRP3 expression.	isoliquiritigenin	21-38	NLR family, pyrin domain containing 3	Rattus norvegicus	123-128
32707499-10	2020	ISLQ administration preserved renal function and architecture, restored Sirt1 and renal oxidant-antioxidant balance, dampened inflammation and attenuated collagen accumulation.	isoliquiritigenin	0-4	sirtuin 1	Rattus norvegicus	72-77
32736296-14	2020	ISL treatment increased the expression of E-cadherin, and decreased the expression of N-cadherin, Slug and Snail.	isoliquiritigenin	0-3	cadherin 1	Homo sapiens	42-52
32736296-14	2020	ISL treatment increased the expression of E-cadherin, and decreased the expression of N-cadherin, Slug and Snail.	isoliquiritigenin	0-3	cadherin 2	Homo sapiens	86-96
32736296-14	2020	ISL treatment increased the expression of E-cadherin, and decreased the expression of N-cadherin, Slug and Snail.	isoliquiritigenin	0-3	snail family transcriptional repressor 2	Homo sapiens	98-102
32736296-14	2020	ISL treatment increased the expression of E-cadherin, and decreased the expression of N-cadherin, Slug and Snail.	isoliquiritigenin	0-3	snail family transcriptional repressor 1	Homo sapiens	107-112
32992605-7	2020	IsoLQ pretreatment in CP-treated cells induces expression of glucose-related proteins 78 and 94 kDa (GRP78 and GRP94, respectively), attenuates CP-induced cell death, decreases reactive oxygen species (ROS) production, and prevents the decrease in glutathione/glutathione disulfide (GSH/GSSG) ratio, free thiols levels, and glutathione reductase (GR) activity.	isoliquiritigenin	0-5	heat shock protein family A (Hsp70) member 5	Sus scrofa	101-106
32992605-7	2020	IsoLQ pretreatment in CP-treated cells induces expression of glucose-related proteins 78 and 94 kDa (GRP78 and GRP94, respectively), attenuates CP-induced cell death, decreases reactive oxygen species (ROS) production, and prevents the decrease in glutathione/glutathione disulfide (GSH/GSSG) ratio, free thiols levels, and glutathione reductase (GR) activity.	isoliquiritigenin	0-5	heat shock protein 90 beta family member 1	Sus scrofa	111-116
32992605-7	2020	IsoLQ pretreatment in CP-treated cells induces expression of glucose-related proteins 78 and 94 kDa (GRP78 and GRP94, respectively), attenuates CP-induced cell death, decreases reactive oxygen species (ROS) production, and prevents the decrease in glutathione/glutathione disulfide (GSH/GSSG) ratio, free thiols levels, and glutathione reductase (GR) activity.	isoliquiritigenin	0-5	glutathione-disulfide reductase	Sus scrofa	324-345
32992605-7	2020	IsoLQ pretreatment in CP-treated cells induces expression of glucose-related proteins 78 and 94 kDa (GRP78 and GRP94, respectively), attenuates CP-induced cell death, decreases reactive oxygen species (ROS) production, and prevents the decrease in glutathione/glutathione disulfide (GSH/GSSG) ratio, free thiols levels, and glutathione reductase (GR) activity.	isoliquiritigenin	0-5	glutathione-disulfide reductase	Sus scrofa	101-103
32638014-0	2020	Isoliquiritigenin inhibits TGF-beta1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells.	isoliquiritigenin	0-17	transforming growth factor beta 1	Homo sapiens	27-36
32638014-0	2020	Isoliquiritigenin inhibits TGF-beta1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells.	isoliquiritigenin	0-17	AKT serine/threonine kinase 1	Homo sapiens	96-99
32638014-0	2020	Isoliquiritigenin inhibits TGF-beta1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells.	isoliquiritigenin	0-17	mechanistic target of rapamycin kinase	Homo sapiens	100-104
32190688-0	2020	Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest.	isoliquiritigenin	0-17	epidermal growth factor receptor	Homo sapiens	78-82
32296334-0	2020	Isoliquiritigenin Derivative Regulates miR-374a/BAX Axis to Suppress Triple-Negative Breast Cancer Tumorigenesis and Development.	isoliquiritigenin	0-17	microRNA 374a	Homo sapiens	39-47
32296334-0	2020	Isoliquiritigenin Derivative Regulates miR-374a/BAX Axis to Suppress Triple-Negative Breast Cancer Tumorigenesis and Development.	isoliquiritigenin	0-17	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51
32190688-6	2020	Exposure to isoliquiritigenin substantially decreased EGF-induced EGFR activation and its downstream Akt and ERK1/2 signaling pathway.	isoliquiritigenin	12-29	epidermal growth factor receptor	Homo sapiens	66-70
32190688-6	2020	Exposure to isoliquiritigenin substantially decreased EGF-induced EGFR activation and its downstream Akt and ERK1/2 signaling pathway.	isoliquiritigenin	12-29	AKT serine/threonine kinase 1	Homo sapiens	101-104
32190688-6	2020	Exposure to isoliquiritigenin substantially decreased EGF-induced EGFR activation and its downstream Akt and ERK1/2 signaling pathway.	isoliquiritigenin	12-29	mitogen-activated protein kinase 3	Homo sapiens	109-115
32117796-7	2020	Linarin, sinensetin, cedar acid, isoliquiritigenin, sinigrin, luteolin, chlorogenic acid, orientin, epigoitrin, and rupestonic acid exhibited significant effects on TNF-alpha expression, which is almost consistent with predicted results.	isoliquiritigenin	33-50	tumor necrosis factor	Homo sapiens	165-174
32141447-0	2020	Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-kappaB and NLRP3 pathways in carrageenan-induced pleurisy.	isoliquiritigenin	0-17	kelch-like ECH-associated protein 1	Mus musculus	88-94
32141447-0	2020	Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-kappaB and NLRP3 pathways in carrageenan-induced pleurisy.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
32141447-0	2020	Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-kappaB and NLRP3 pathways in carrageenan-induced pleurisy.	isoliquiritigenin	0-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
32141447-0	2020	Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-kappaB and NLRP3 pathways in carrageenan-induced pleurisy.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	141-146
31004603-14	2019	Overall, isoliquiritigenin was confirmed to be a potent anti-nasopharyngeal carcinoma compound both in vitro and in vivo, and accomplished by regulation of miR-32/LATS2/Wnt.	isoliquiritigenin	9-26	large tumor suppressor kinase 2	Homo sapiens	163-168
31785162-0	2020	Isoliquiritigenin inhibits melanogenesis, melanocyte dendricity and melanosome transport by regulating ERK-mediated MITF degradation.	isoliquiritigenin	0-17	mitogen-activated protein kinase 1	Homo sapiens	103-106
31785162-0	2020	Isoliquiritigenin inhibits melanogenesis, melanocyte dendricity and melanosome transport by regulating ERK-mediated MITF degradation.	isoliquiritigenin	0-17	melanocyte inducing transcription factor	Homo sapiens	116-120
31785162-2	2020	It has been reported that ISL inhibited melanogenesis by suppressing the tyrosinase activity in human melanocytes.	isoliquiritigenin	26-29	tyrosinase	Homo sapiens	73-83
31785162-6	2020	Our results suggested that ISL suppressed basal and alpha-MSH-, ACTH- and UV-induced melanin synthesis, in addition to inhibiting melanocyte dendricity and melanosome transport.	isoliquiritigenin	27-30	proopiomelanocortin	Homo sapiens	52-61
31785162-7	2020	ISL played these roles mainly by activating the ERK pathway.	isoliquiritigenin	0-3	mitogen-activated protein kinase 1	Homo sapiens	48-51
31860659-0	2019	In vitro activity and In vivo efficacy of Isoliquiritigenin against Staphylococcus xylosus ATCC 700404 by IGPD target.	isoliquiritigenin	42-59	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	106-110
31860659-9	2019	The results indicated that the activity of IGPD and its histidine content decreased significantly under 1/2 MIC (40 mug/mL) ISL, and the expression of IGPD gene (hisB) and IGPD protein was significantly down-regulated.	isoliquiritigenin	124-127	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	43-47
31860659-10	2019	Furthermore, Bio-layer interferometry experiments showed that ISL directly interacted with IGPD protein (with strong affinity; KD = 234 muM).	isoliquiritigenin	62-65	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	91-95
31860659-12	2019	In vivo tests revealed that, ISL significantly reduced TNF-alpha and IL-6 levels, mitigated the destruction of the mammary glands and reversed the production of inflammatory cells in mice.	isoliquiritigenin	29-32	tumor necrosis factor	Mus musculus	55-64
31860659-12	2019	In vivo tests revealed that, ISL significantly reduced TNF-alpha and IL-6 levels, mitigated the destruction of the mammary glands and reversed the production of inflammatory cells in mice.	isoliquiritigenin	29-32	interleukin 6	Mus musculus	69-73
31860659-13	2019	The results of the study suggest that, ISL may inhibit S. xylosus growth by acting on IGPD, which can be used as a target protein to treat infections caused by S. xylosus.	isoliquiritigenin	39-42	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	86-90
31462456-0	2019	Isoliquiritigenin, an Orally Available Natural FLT3 Inhibitor from Licorice, Exhibits Selective Anti-Acute Myeloid Leukemia Efficacy In Vitro and In Vivo.	isoliquiritigenin	0-17	fms related receptor tyrosine kinase 3	Homo sapiens	47-51
31438982-0	2019	Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1.	isoliquiritigenin	42-59	prostaglandin E synthase	Mus musculus	21-28
31438982-0	2019	Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1.	isoliquiritigenin	42-59	AKT serine/threonine kinase 1	Homo sapiens	82-85
31438982-0	2019	Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1.	isoliquiritigenin	42-59	nuclear paraspeckle assembly transcript 1	Homo sapiens	152-157
31840737-0	2020	Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway.	isoliquiritigenin	0-17	cyclin D1	Homo sapiens	102-111
31840737-0	2020	Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway.	isoliquiritigenin	0-17	AKT serine/threonine kinase 1	Homo sapiens	121-124
31840737-8	2020	Mechanistic analysis revealed that ISL inhibited cyclin D1 and up-regulated the proteins P21, P27 that negatively regulate the cell cycle.	isoliquiritigenin	35-38	cyclin D1	Homo sapiens	49-58
31840737-8	2020	Mechanistic analysis revealed that ISL inhibited cyclin D1 and up-regulated the proteins P21, P27 that negatively regulate the cell cycle.	isoliquiritigenin	35-38	H3 histone pseudogene 16	Homo sapiens	89-92
31840737-8	2020	Mechanistic analysis revealed that ISL inhibited cyclin D1 and up-regulated the proteins P21, P27 that negatively regulate the cell cycle.	isoliquiritigenin	35-38	interferon alpha inducible protein 27	Homo sapiens	94-97
31840737-10	2020	In addition, phosphatidylinositol 3"-kinase/protein kinase B (PI3K/AKT) signal pathway was suppressed by ISL treatment, and the epithelial marker E-cadherin was up-regulated when the mesenchymal markers Vimentin and N-cadherin were down-regulated.	isoliquiritigenin	105-108	protein tyrosine kinase 2 beta	Homo sapiens	44-60
31840737-10	2020	In addition, phosphatidylinositol 3"-kinase/protein kinase B (PI3K/AKT) signal pathway was suppressed by ISL treatment, and the epithelial marker E-cadherin was up-regulated when the mesenchymal markers Vimentin and N-cadherin were down-regulated.	isoliquiritigenin	105-108	AKT serine/threonine kinase 1	Homo sapiens	67-70
31840737-10	2020	In addition, phosphatidylinositol 3"-kinase/protein kinase B (PI3K/AKT) signal pathway was suppressed by ISL treatment, and the epithelial marker E-cadherin was up-regulated when the mesenchymal markers Vimentin and N-cadherin were down-regulated.	isoliquiritigenin	105-108	vimentin	Homo sapiens	203-211
31840737-10	2020	In addition, phosphatidylinositol 3"-kinase/protein kinase B (PI3K/AKT) signal pathway was suppressed by ISL treatment, and the epithelial marker E-cadherin was up-regulated when the mesenchymal markers Vimentin and N-cadherin were down-regulated.	isoliquiritigenin	105-108	cadherin 2	Homo sapiens	216-226
31037573-0	2019	Neuroprotective and anti-inflammatory effects of isoliquiritigenin in kainic acid-induced epileptic rats via the TLR4/MYD88 signaling pathway.	isoliquiritigenin	49-66	toll-like receptor 4	Rattus norvegicus	113-117
31037573-0	2019	Neuroprotective and anti-inflammatory effects of isoliquiritigenin in kainic acid-induced epileptic rats via the TLR4/MYD88 signaling pathway.	isoliquiritigenin	49-66	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	118-123
31004603-0	2019	Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.	isoliquiritigenin	0-17	microRNA 32	Homo sapiens	73-79
31004603-0	2019	Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.	isoliquiritigenin	0-17	large tumor suppressor kinase 2	Homo sapiens	80-85
31004603-5	2019	In addition, isoliquiritigenin promoted nasopharyngeal carcinoma cell apoptosis, with the up-regulations of Bax, Caspase-3 and Caspase-9 and the down-regulation of Bcl-2.	isoliquiritigenin	13-30	BCL2 associated X, apoptosis regulator	Homo sapiens	108-111
31004603-5	2019	In addition, isoliquiritigenin promoted nasopharyngeal carcinoma cell apoptosis, with the up-regulations of Bax, Caspase-3 and Caspase-9 and the down-regulation of Bcl-2.	isoliquiritigenin	13-30	caspase 3	Homo sapiens	113-122
31004603-5	2019	In addition, isoliquiritigenin promoted nasopharyngeal carcinoma cell apoptosis, with the up-regulations of Bax, Caspase-3 and Caspase-9 and the down-regulation of Bcl-2.	isoliquiritigenin	13-30	caspase 9	Homo sapiens	127-136
31004603-5	2019	In addition, isoliquiritigenin promoted nasopharyngeal carcinoma cell apoptosis, with the up-regulations of Bax, Caspase-3 and Caspase-9 and the down-regulation of Bcl-2.	isoliquiritigenin	13-30	BCL2 apoptosis regulator	Homo sapiens	164-169
31004603-6	2019	Meanwhile, isoliquiritigenin suppressed nasopharyngeal carcinoma cells migration and invasion with the down-regulation of matrix metalloproteinases (MMP)-2 and MMP-9.	isoliquiritigenin	11-28	matrix metallopeptidase 2	Homo sapiens	122-155
31004603-6	2019	Meanwhile, isoliquiritigenin suppressed nasopharyngeal carcinoma cells migration and invasion with the down-regulation of matrix metalloproteinases (MMP)-2 and MMP-9.	isoliquiritigenin	11-28	matrix metallopeptidase 9	Homo sapiens	160-165
31004603-7	2019	Furthermore, the expression of miR-32 was up-regulated in the nasopharyngeal carcinoma tissues, while isoliquiritigenin could significantly down-regulate the expression of miR-32.	isoliquiritigenin	102-119	microRNA 32	Homo sapiens	172-178
31004603-9	2019	However, isoliquiritigenin treatment dramatically inhibited the effect of miR-32.	isoliquiritigenin	9-26	microRNA 32	Homo sapiens	74-80
31004603-11	2019	And isoliquiritigenin increased the expression of LATS2, while silencing of LATS2 promoted the nasopharyngeal carcinoma cells growth.	isoliquiritigenin	4-21	large tumor suppressor kinase 2	Homo sapiens	50-55
29943151-0	2019	Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-kappaB.	isoliquiritigenin	21-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
31004603-13	2019	Finally, CNE2 cells transplanted xenografts tumor model in nude mice were performed and it suggested that isoliquiritigenin could inhibit the development of xenografts nude mice, along with the decrease of tumor volume and the expression of miR-32 and LATS2.	isoliquiritigenin	106-123	microRNA 32	Mus musculus	241-247
31004603-13	2019	Finally, CNE2 cells transplanted xenografts tumor model in nude mice were performed and it suggested that isoliquiritigenin could inhibit the development of xenografts nude mice, along with the decrease of tumor volume and the expression of miR-32 and LATS2.	isoliquiritigenin	106-123	large tumor suppressor 2	Mus musculus	252-257
31004603-14	2019	Overall, isoliquiritigenin was confirmed to be a potent anti-nasopharyngeal carcinoma compound both in vitro and in vivo, and accomplished by regulation of miR-32/LATS2/Wnt.	isoliquiritigenin	9-26	microRNA 32	Homo sapiens	156-162
31083310-8	2019	NF-kappaB translocation from cytoplasm to nucleus was observed after LPS stimulation for 2 h and was attenuated by extracts of Glycyrrhiza glabra and Eriobotrya japonica, as well as by 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid.	isoliquiritigenin	213-230	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
31444000-2	2019	Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels.	isoliquiritigenin	0-17	CF transmembrane conductance regulator	Homo sapiens	144-148
31444000-2	2019	Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels.	isoliquiritigenin	19-23	CF transmembrane conductance regulator	Homo sapiens	144-148
31083310-7	2019	LPS upregulated gene expressions of NF-kappaB subunits and of ICAM-1, TNF-alpha, iNOS, and COX-2 within 8 h, which could be decreased by 18beta glycyrrhetinic acid, isoliquiritigenin and ursolic acid similarly to the anti-inflammatory drug dexamethasone.	isoliquiritigenin	165-182	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	36-45
31083310-7	2019	LPS upregulated gene expressions of NF-kappaB subunits and of ICAM-1, TNF-alpha, iNOS, and COX-2 within 8 h, which could be decreased by 18beta glycyrrhetinic acid, isoliquiritigenin and ursolic acid similarly to the anti-inflammatory drug dexamethasone.	isoliquiritigenin	165-182	intercellular adhesion molecule 1	Mus musculus	62-68
31354498-0	2019	Corrigendum: Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling.	isoliquiritigenin	13-30	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
30698296-0	2019	Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest via ROS-mediated MAPK/STAT3/NF-kappaB pathways in human hepatocellular carcinoma cells.	isoliquiritigenin	22-39	mitogen-activated protein kinase 1	Homo sapiens	97-101
30698296-0	2019	Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest via ROS-mediated MAPK/STAT3/NF-kappaB pathways in human hepatocellular carcinoma cells.	isoliquiritigenin	22-39	signal transducer and activator of transcription 3	Homo sapiens	102-107
30698296-0	2019	Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest via ROS-mediated MAPK/STAT3/NF-kappaB pathways in human hepatocellular carcinoma cells.	isoliquiritigenin	22-39	nuclear factor kappa B subunit 1	Homo sapiens	108-117
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	isoliquiritigenin	41-58	intercellular adhesion molecule 1	Mus musculus	111-117
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	isoliquiritigenin	41-58	tumor necrosis factor	Mus musculus	119-128
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	isoliquiritigenin	41-58	cytochrome c oxidase II, mitochondrial	Mus musculus	130-135
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	isoliquiritigenin	41-58	nitric oxide synthase 2, inducible	Mus musculus	141-145
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	isoliquiritigenin	41-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	173-182
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	isoliquiritigenin	41-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	210-219
30637601-0	2019	Correction to: Isoliquiritigenin Provides Protection and Attenuates Oxidative Stress-Induced Injuries via the Nrf2-ARE Signaling Pathway After Traumatic Brain Injury.	isoliquiritigenin	15-32	NFE2 like bZIP transcription factor 2	Homo sapiens	110-114
32269833-7	2019	Here we show that ISLQ has potent cytotoxic effects on SK-N-BE(2) and IMR-32 human NB cells, which carry amplification of the MYCN gene, the main prognostic marker of poor survival in NB.	isoliquiritigenin	18-22	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	126-130
32269833-11	2019	This study provides proof-of-principle that ISLQ is a potent cytotoxin for MYCN-amplified human NB cells.	isoliquiritigenin	44-48	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	75-79
30565859-0	2019	Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4.	isoliquiritigenin	64-81	bromodomain containing 4	Homo sapiens	110-114
30565859-3	2019	Using X-ray crystallographic screening, we identified the BRD4 inhibitory activity of isoliquiritigenin (ISL), a natural chalcone found in licorice.	isoliquiritigenin	86-103	bromodomain containing 4	Homo sapiens	58-62
30565859-3	2019	Using X-ray crystallographic screening, we identified the BRD4 inhibitory activity of isoliquiritigenin (ISL), a natural chalcone found in licorice.	isoliquiritigenin	105-108	bromodomain containing 4	Homo sapiens	58-62
30684867-3	2019	Thioflavin-T assay indicated trihydroxy chalcones inhibited Abeta aggregation better.	isoliquiritigenin	29-49	amyloid beta precursor protein	Homo sapiens	60-65
30668421-0	2019	Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1.	isoliquiritigenin	0-17	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	111-116
30783039-11	2019	Isoliquiritigenin also reduced the level of proinflammatory cytokines and Bax and increased Bcl-2 and Bcl-xL in TBI rats.	isoliquiritigenin	0-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	74-77
30805086-0	2019	Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells.	isoliquiritigenin	0-17	CDGSH iron sulfur domain 1	Homo sapiens	80-88
30805086-2	2019	In the current study, we found that isoliquiritigenin (ISL), one of the components of the root of Glycyrrhiza glabra L., could decrease the expression of mitoNEET in A375 melanoma cells.	isoliquiritigenin	36-53	CDGSH iron sulfur domain 1	Homo sapiens	154-162
30783039-11	2019	Isoliquiritigenin also reduced the level of proinflammatory cytokines and Bax and increased Bcl-2 and Bcl-xL in TBI rats.	isoliquiritigenin	0-17	BCL2, apoptosis regulator	Rattus norvegicus	92-97
30783039-11	2019	Isoliquiritigenin also reduced the level of proinflammatory cytokines and Bax and increased Bcl-2 and Bcl-xL in TBI rats.	isoliquiritigenin	0-17	Bcl2-like 1	Rattus norvegicus	102-108
30340829-0	2018	Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines and oxidative stress-induced apoptosis via Nrf2 and NF-kappaB pathways.	isoliquiritigenin	0-17	angiotensinogen	Homo sapiens	33-39
30662657-2	2018	Isoliquiritigenin (ISL) as a small molecular from licorice, is able to inhibit the expression of HMGB1.	isoliquiritigenin	0-17	high mobility group box 1	Homo sapiens	97-102
30662657-2	2018	Isoliquiritigenin (ISL) as a small molecular from licorice, is able to inhibit the expression of HMGB1.	isoliquiritigenin	19-22	high mobility group box 1	Homo sapiens	97-102
30339814-0	2018	Isoliquiritigenin-mediated p62/SQSTM1 induction regulates apoptotic potential through attenuation of caspase-8 activation in colorectal cancer cells.	isoliquiritigenin	0-17	sequestosome 1	Homo sapiens	27-30
30339814-0	2018	Isoliquiritigenin-mediated p62/SQSTM1 induction regulates apoptotic potential through attenuation of caspase-8 activation in colorectal cancer cells.	isoliquiritigenin	0-17	sequestosome 1	Homo sapiens	31-37
30339814-0	2018	Isoliquiritigenin-mediated p62/SQSTM1 induction regulates apoptotic potential through attenuation of caspase-8 activation in colorectal cancer cells.	isoliquiritigenin	0-17	caspase 8	Homo sapiens	101-110
30339814-6	2018	In a p62/SQSTM1 siRNA transfection study, ISL-induced p62/SQSTM1 expression attenuated ISL-mediated apoptosis by reducing caspase-8 activation.	isoliquiritigenin	42-45	sequestosome 1	Homo sapiens	5-8
30339814-6	2018	In a p62/SQSTM1 siRNA transfection study, ISL-induced p62/SQSTM1 expression attenuated ISL-mediated apoptosis by reducing caspase-8 activation.	isoliquiritigenin	42-45	sequestosome 1	Homo sapiens	9-15
30339814-6	2018	In a p62/SQSTM1 siRNA transfection study, ISL-induced p62/SQSTM1 expression attenuated ISL-mediated apoptosis by reducing caspase-8 activation.	isoliquiritigenin	42-45	sequestosome 1	Homo sapiens	54-57
30339814-6	2018	In a p62/SQSTM1 siRNA transfection study, ISL-induced p62/SQSTM1 expression attenuated ISL-mediated apoptosis by reducing caspase-8 activation.	isoliquiritigenin	42-45	sequestosome 1	Homo sapiens	58-64
30339814-6	2018	In a p62/SQSTM1 siRNA transfection study, ISL-induced p62/SQSTM1 expression attenuated ISL-mediated apoptosis by reducing caspase-8 activation.	isoliquiritigenin	42-45	caspase 8	Homo sapiens	122-131
30339814-9	2018	Our results demonstrate that ISL-induced p62/SQSTM1 upregulation affects ISL-mediated apoptotic potential through attenuation of caspase-8 activation in CRC cells.	isoliquiritigenin	29-32	sequestosome 1	Homo sapiens	41-44
30339814-9	2018	Our results demonstrate that ISL-induced p62/SQSTM1 upregulation affects ISL-mediated apoptotic potential through attenuation of caspase-8 activation in CRC cells.	isoliquiritigenin	29-32	sequestosome 1	Homo sapiens	45-51
30339814-9	2018	Our results demonstrate that ISL-induced p62/SQSTM1 upregulation affects ISL-mediated apoptotic potential through attenuation of caspase-8 activation in CRC cells.	isoliquiritigenin	29-32	caspase 8	Homo sapiens	129-138
30339814-9	2018	Our results demonstrate that ISL-induced p62/SQSTM1 upregulation affects ISL-mediated apoptotic potential through attenuation of caspase-8 activation in CRC cells.	isoliquiritigenin	73-76	sequestosome 1	Homo sapiens	41-44
30339814-9	2018	Our results demonstrate that ISL-induced p62/SQSTM1 upregulation affects ISL-mediated apoptotic potential through attenuation of caspase-8 activation in CRC cells.	isoliquiritigenin	73-76	sequestosome 1	Homo sapiens	45-51
30446968-0	2018	Isoliquiritigenin Provides Protection and Attenuates Oxidative Stress-Induced Injuries via the Nrf2-ARE Signaling Pathway After Traumatic Brain Injury.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
30464238-5	2018	Selected bioactives, sulforaphane, apigenin, isoliquiritigenin and luteolin, inhibited one or more interleukin-1-induced metalloproteinases implicated in OA (MMP1, MMP13, ADAMTS4, ADAMTS5).	isoliquiritigenin	45-62	matrix metallopeptidase 1	Homo sapiens	158-162
30464238-5	2018	Selected bioactives, sulforaphane, apigenin, isoliquiritigenin and luteolin, inhibited one or more interleukin-1-induced metalloproteinases implicated in OA (MMP1, MMP13, ADAMTS4, ADAMTS5).	isoliquiritigenin	45-62	matrix metallopeptidase 13	Homo sapiens	164-169
30464238-5	2018	Selected bioactives, sulforaphane, apigenin, isoliquiritigenin and luteolin, inhibited one or more interleukin-1-induced metalloproteinases implicated in OA (MMP1, MMP13, ADAMTS4, ADAMTS5).	isoliquiritigenin	45-62	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	171-178
30464238-10	2018	The combination of sulforaphane and isoliquiritigenin was synergistic for inhibiting MMP13 gene expression in chondrocytes.	isoliquiritigenin	36-53	matrix metallopeptidase 13	Homo sapiens	85-90
30340829-0	2018	Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines and oxidative stress-induced apoptosis via Nrf2 and NF-kappaB pathways.	isoliquiritigenin	0-17	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
30344755-0	2018	Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells.	isoliquiritigenin	0-17	AKT serine/threonine kinase 1	Homo sapiens	77-80
30171855-0	2018	Isoliquiritigenin inhibits mouse S180 tumors with a new mechanism that regulates autophagy by GSK-3beta/TNF-alpha pathway.	isoliquiritigenin	0-17	glycogen synthase kinase 3 beta	Mus musculus	94-103
30171855-0	2018	Isoliquiritigenin inhibits mouse S180 tumors with a new mechanism that regulates autophagy by GSK-3beta/TNF-alpha pathway.	isoliquiritigenin	0-17	tumor necrosis factor	Mus musculus	104-113
30275324-5	2018	By screening, we identified three molecules isolated from medicinal plants, andrographolide, oridonin, and isoliquiritigenin, which induced HBD3 production in human colonic epithelial cells.	isoliquiritigenin	107-124	defensin beta 103B	Homo sapiens	140-144
30275324-9	2018	Interestingly, stimulating cells with a combination of andrographolide and isoliquiritigenin synergistically enhanced HBD3 induction 10-fold more than observed with each molecule alone.	isoliquiritigenin	75-92	defensin beta 103B	Homo sapiens	118-122
30093114-6	2018	Ingredients of G. uralensis such as licochalcone A (LicoA), isoliquiritigenin, and liquiritigenin induced UCP1 expression in 3T3-L1 adipocytes.	isoliquiritigenin	60-77	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	106-110
29979476-4	2018	Chalcone reductase (CHR) is a key enzyme mediating 5-deoxyisoflavonoid biosynthesis because it catalyzes the production of 6"-deoxychalcone through its effects on the chalcone synthase (CHS)-catalyzed reaction.	isoliquiritigenin	123-139	chalcone reductase	Glycine max	0-18
29979476-4	2018	Chalcone reductase (CHR) is a key enzyme mediating 5-deoxyisoflavonoid biosynthesis because it catalyzes the production of 6"-deoxychalcone through its effects on the chalcone synthase (CHS)-catalyzed reaction.	isoliquiritigenin	123-139	chalcone reductase	Glycine max	20-23
29979476-8	2018	In the in vitro assays, the ratio of CHR products (6"-deoxychalcone) to total CHS products (R value) was dependent on GmCHR5 and CHS concentrations, with higher concentrations resulting in higher R values (i.e. approaching 90%).	isoliquiritigenin	51-67	chalcone reductase	Glycine max	37-40
30294270-0	2018	Isoliquiritigenin Inhibits Cigarette Smoke-Induced COPD by Attenuating Inflammation and Oxidative Stress via the Regulation of the Nrf2 and NF-kappaB Signaling Pathways.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
30294270-0	2018	Isoliquiritigenin Inhibits Cigarette Smoke-Induced COPD by Attenuating Inflammation and Oxidative Stress via the Regulation of the Nrf2 and NF-kappaB Signaling Pathways.	isoliquiritigenin	0-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	140-149
30174606-0	2018	Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling.	isoliquiritigenin	0-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
30066879-0	2018	Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway.	isoliquiritigenin	0-17	AKT serine/threonine kinase 1	Homo sapiens	110-113
30066879-0	2018	Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway.	isoliquiritigenin	0-17	mechanistic target of rapamycin kinase	Homo sapiens	114-118
30048666-0	2018	Isoliquiritigenin attenuates glutamate-induced mitochondrial fission via calcineurin-mediated Drp1 dephosphorylation in HT22 hippocampal neuron cells.	isoliquiritigenin	0-17	collapsin response mediator protein 1	Mus musculus	94-98
29654430-0	2018	Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-gamma.	isoliquiritigenin	22-39	toll-like receptor 4	Mus musculus	43-46
29654430-0	2018	Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-gamma.	isoliquiritigenin	22-39	peroxisome proliferator activated receptor gamma	Mus musculus	87-97
30081934-0	2018	Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling.	isoliquiritigenin	0-17	microRNA 301b	Homo sapiens	64-72
30081934-0	2018	Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling.	isoliquiritigenin	0-17	leucine rich repeats and immunoglobulin like domains 1	Homo sapiens	73-78