PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35454893-5	2022	TNTs are upregulated in malignant mesothelioma; we used this model to analyze the biophysical properties of TNTs in this 3D setting, including cell migration in relation to TNT dynamics, rate of TNT-mediated intercellular transport of cargo, and conformation of TNT-forming cells.	tnts	108-112	chromosome 16 open reading frame 82	Homo sapiens	173-176
34944949-6	2021	Moreover, using confocal fluorescence time-lapse microscopy, we show in 5637 cells that TNTs mediate the trafficking of RalA protein and transmembrane MHC class III protein leukocyte-specific transcript 1 (LST1).	tnts	88-92	RAS like proto-oncogene A	Homo sapiens	120-124
34944949-6	2021	Moreover, using confocal fluorescence time-lapse microscopy, we show in 5637 cells that TNTs mediate the trafficking of RalA protein and transmembrane MHC class III protein leukocyte-specific transcript 1 (LST1).	tnts	88-92	leukocyte specific transcript 1	Homo sapiens	173-204
34944949-6	2021	Moreover, using confocal fluorescence time-lapse microscopy, we show in 5637 cells that TNTs mediate the trafficking of RalA protein and transmembrane MHC class III protein leukocyte-specific transcript 1 (LST1).	tnts	88-92	leukocyte specific transcript 1	Homo sapiens	206-210
34944949-9	2021	In conclusion, our findings suggest that in the tumor microenvironment, RalGPS2 orchestrates the assembly of multimolecular complexes that drive the formation of TNTs.	tnts	162-166	Ral GEF with PH domain and SH3 binding motif 2	Homo sapiens	72-79
26220176-4	2015	Using 3-dimensional quantitative and qualitative confocal microscopy, we showed that TNTs contain green fluorescent protein (GFP)-early endosome antigen (EEA) 1, GFP Rab5, GFP Rab11, GFP Rab8, transferrin (Tf), and Tf receptor (Tf-R) fused to mCherry (Tf-RmCherry).	tnts	85-89	early endosome antigen 1	Mus musculus	130-160
26220176-4	2015	Using 3-dimensional quantitative and qualitative confocal microscopy, we showed that TNTs contain green fluorescent protein (GFP)-early endosome antigen (EEA) 1, GFP Rab5, GFP Rab11, GFP Rab8, transferrin (Tf), and Tf receptor (Tf-R) fused to mCherry (Tf-RmCherry).	tnts	85-89	RAB11A, member RAS oncogene family	Mus musculus	176-181
26220176-4	2015	Using 3-dimensional quantitative and qualitative confocal microscopy, we showed that TNTs contain green fluorescent protein (GFP)-early endosome antigen (EEA) 1, GFP Rab5, GFP Rab11, GFP Rab8, transferrin (Tf), and Tf receptor (Tf-R) fused to mCherry (Tf-RmCherry).	tnts	85-89	transferrin	Mus musculus	193-204
35454893-5	2022	TNTs are upregulated in malignant mesothelioma; we used this model to analyze the biophysical properties of TNTs in this 3D setting, including cell migration in relation to TNT dynamics, rate of TNT-mediated intercellular transport of cargo, and conformation of TNT-forming cells.	tnts	108-112	chromosome 16 open reading frame 82	Homo sapiens	195-198
35454893-5	2022	TNTs are upregulated in malignant mesothelioma; we used this model to analyze the biophysical properties of TNTs in this 3D setting, including cell migration in relation to TNT dynamics, rate of TNT-mediated intercellular transport of cargo, and conformation of TNT-forming cells.	tnts	108-112	chromosome 16 open reading frame 82	Homo sapiens	262-265
33866130-7	2021	"Moreover", based on the similarity of the processes of development of synaptic spines and TNT formation, we argue that TNTs in the brain predate synaptic transmission, being instrumental in the orchestration of the immature neuronal circuit.	tnts	120-124	troponin T1, slow skeletal type	Homo sapiens	91-94
35204813-8	2022	We found that HIV-C significantly increased the formation of TNTs between DCs or DC/CD4+ T-cell co-cultures compared to HIV-exposed DCs or co-cultures.	tnts	61-65	CD4 molecule	Homo sapiens	84-87
33722931-7	2021	RESULTS: Podocytes can form TNTs in a M-Sec-dependent manner.	tnts	28-32	tumor necrosis factor, alpha-induced protein 2	Mus musculus	38-43
33752184-6	2021	The conformation of the protein adsorbed to the substrates was analyzed at the molecular level by Fourier-transform infrared reflection absorption spectroscopy, which revealed that the BSA adsorbed on the polyzwitterion-modified TNTs adopted significantly different secondary structures from that on the virgin TNTs, whereas the conformation of the adsorbed Fib remained basically the same.	tnts	229-233	fibrinogen beta chain	Homo sapiens	358-361
33947577-4	2021	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.	tnts	133-137	interleukin 4	Rattus norvegicus	195-213
33277565-4	2020	TNT@MB was prepared by adsorbing methyl blue onto TNTs in acidic condition.	tnts	50-54	chromosome 16 open reading frame 82	Homo sapiens	0-3
33439005-4	2021	The hybrid nanostructure (Au/CdS QDs/TNTs) electrode exhibited about a 6-fold increase in sensitivity for both cholesterol (10,790 muA mM-1 cm-2) and H2O2 (78,833 muA mM-1 cm-2) in analyses compared to the pristine samples.	tnts	37-41	Mix1 homeobox-like 1 (Xenopus laevis)	Mus musculus	135-144
33439005-4	2021	The hybrid nanostructure (Au/CdS QDs/TNTs) electrode exhibited about a 6-fold increase in sensitivity for both cholesterol (10,790 muA mM-1 cm-2) and H2O2 (78,833 muA mM-1 cm-2) in analyses compared to the pristine samples.	tnts	37-41	Mix1 homeobox-like 1 (Xenopus laevis)	Mus musculus	167-176
32693732-6	2020	Macrophage response showed that IL-4 functionalized TNTs favored macrophage polarization towards an anti-inflammatory M2-phenotype.	tnts	52-56	interleukin 4	Homo sapiens	32-36
33003486-8	2020	Notably, secreted factors present in conditioned medium stimulated TNTs more potently when derived from Cx43-expressing cells than from KO cells.	tnts	67-71	gap junction protein alpha 1	Homo sapiens	104-108
32806259-6	2020	In contrast, protein levels of nitric oxide (NO) and proinflammatory cytokines (TNF-alpha and IL-1beta) from macrophages on Dex-filled TNTs, CHI-coated TNTs and CHI-coated Dex-filled TNTs were significantly lower, especially on CHI-coated Dex-filled TNTs surfaces compared to levels on titanium and TNTs.	tnts	135-139	tumor necrosis factor	Mus musculus	80-89
32806259-6	2020	In contrast, protein levels of nitric oxide (NO) and proinflammatory cytokines (TNF-alpha and IL-1beta) from macrophages on Dex-filled TNTs, CHI-coated TNTs and CHI-coated Dex-filled TNTs were significantly lower, especially on CHI-coated Dex-filled TNTs surfaces compared to levels on titanium and TNTs.	tnts	135-139	interleukin 1 alpha	Mus musculus	94-102
31756994-6	2019	The size and amount of the AuNPs could be controlled by the number of deposition cycles and the concentration of the gold salt solution.The modification of TNTs using AuNPs facilitated electron transfer, increased the corrosion resistance, and caused better adsorption properties for bovine serum albumin.	tnts	156-160	albumin	Homo sapiens	291-304
32467880-7	2019	Aim: The aim of this study was to determine whether EGF was required for macrophage induced tumor cell TNTs in an M-Sec dependent manner and what possible roles tumor cell TNTs play in tumor cell migration and invasion.	tnts	103-107	epidermal growth factor like 1	Rattus norvegicus	52-55
31298767-9	2020	We observed a significant increase in p16 expression in high-passage cells when TNT formation was inhibited, establishing the importance of TNTs in MSC spheroids.	tnts	140-144	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-41
30980873-4	2019	Interleukin (IL)-4, an anti-inflammatory cytokine, was loaded into titania nanotubes (TNTs) on the titanium surface.	tnts	86-90	interleukin 4	Homo sapiens	0-18
30980873-5	2019	Subsequently, sodium alginate (ALG) and chitosan (CS) were alternately assembled onto IL-4-loaded TNTs and cross-linked with genipin/calcium chloride, finally forming cross-linked PEM films.	tnts	98-102	interleukin 4	Homo sapiens	86-90
31127190-5	2019	Stress-induced chaperones clusterin and YB-1 localize within TNTs, are transported bi-directionally via TNTs and facilitate TNT formation in PI3K/AKT and Eps8-dependent manner.	tnts	61-65	AKT serine/threonine kinase 1	Homo sapiens	146-149
30936010-4	2019	Interleukin (IL)-4, an anti-inflammatory cytokine, was loaded into titania nanotubes (TNTs) on the titanium surface.	tnts	86-90	interleukin 4	Homo sapiens	0-18
30936010-5	2019	Subsequently, sodium alginate (ALG) and chitosan (CS) were alternately assembled onto IL-4-loaded TNTs and cross-linked with genipin/calcium chloride, finally forming cross-linked PEM films.	tnts	98-102	interleukin 4	Homo sapiens	86-90
33405609-9	2019	Besides, the hybrid nanosurface TNT/HA coating was found to improve the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells compared to pure TNTs.	tnts	163-167	troponin T1, skeletal, slow	Mus musculus	32-35
30443895-2	2019	The unconventional actin molecular motor protein Myosin-X (Myo10) is a known inducer of TNTs in neuronal cells, yet its role in other cell types has not been examined.	tnts	88-92	myosin X	Homo sapiens	49-57
30443895-2	2019	The unconventional actin molecular motor protein Myosin-X (Myo10) is a known inducer of TNTs in neuronal cells, yet its role in other cell types has not been examined.	tnts	88-92	myosin X	Homo sapiens	59-64
30443895-3	2019	The Nef HIV-1 accessory protein is critical for HIV-1 pathogenesis and can self-disseminate in culture via TNTs.	tnts	107-111	Nef	Human immunodeficiency virus 1	4-7
30443895-6	2019	We demonstrate that Nef increases TNTs in a Myo10-dependent manner in macrophages and observed the transfer of Nef via TNTs from macrophages to T cells.	tnts	34-38	S100 calcium binding protein B	Homo sapiens	20-23
30443895-6	2019	We demonstrate that Nef increases TNTs in a Myo10-dependent manner in macrophages and observed the transfer of Nef via TNTs from macrophages to T cells.	tnts	34-38	myosin X	Homo sapiens	44-49
30443895-6	2019	We demonstrate that Nef increases TNTs in a Myo10-dependent manner in macrophages and observed the transfer of Nef via TNTs from macrophages to T cells.	tnts	119-123	S100 calcium binding protein B	Homo sapiens	20-23
30443895-6	2019	We demonstrate that Nef increases TNTs in a Myo10-dependent manner in macrophages and observed the transfer of Nef via TNTs from macrophages to T cells.	tnts	119-123	S100 calcium binding protein B	Homo sapiens	111-114
30443895-10	2019	We demonstrate that Nef transfer occurs via a cell-to-cell dependent mechanism that directly correlates with the presence of Myo10-dependent TNTs.	tnts	141-145	S100 calcium binding protein B	Homo sapiens	20-23
30443895-10	2019	We demonstrate that Nef transfer occurs via a cell-to-cell dependent mechanism that directly correlates with the presence of Myo10-dependent TNTs.	tnts	141-145	myosin X	Homo sapiens	125-130
31127190-5	2019	Stress-induced chaperones clusterin and YB-1 localize within TNTs, are transported bi-directionally via TNTs and facilitate TNT formation in PI3K/AKT and Eps8-dependent manner.	tnts	61-65	epidermal growth factor receptor pathway substrate 8	Homo sapiens	154-158
31127190-5	2019	Stress-induced chaperones clusterin and YB-1 localize within TNTs, are transported bi-directionally via TNTs and facilitate TNT formation in PI3K/AKT and Eps8-dependent manner.	tnts	104-108	AKT serine/threonine kinase 1	Homo sapiens	146-149
31127190-5	2019	Stress-induced chaperones clusterin and YB-1 localize within TNTs, are transported bi-directionally via TNTs and facilitate TNT formation in PI3K/AKT and Eps8-dependent manner.	tnts	104-108	epidermal growth factor receptor pathway substrate 8	Homo sapiens	154-158
30305100-8	2018	CONCLUSIONS: This finding suggests for the first time that loss of RASSF1A expression could be a potential biomarker for TNTs formation, such TNTs facilitating intercellular communication favoring multistep progression of bronchial epithelial cells toward overt malignancy.	tnts	142-146	Ras association domain family member 1	Homo sapiens	67-74
30808254-4	2019	TNT formation between MSCs and HUVECs could be induced by treating HUVECs with cytarabine (Ara-C), and human bone marrow mesenchymal stem cells (hBMMSCs) could transfer mitochondria to injured HUVECs through TNTs.	tnts	208-212	chromosome 16 open reading frame 82	Homo sapiens	0-3
30917314-6	2019	TNT formation requires the IL-10/STAT3 signaling pathway, and targeted inhibition of TNTs substantially reduces the enhancement of HIV-1 cell-to-cell transfer and overproduction in M(IL-10) macrophages.	tnts	85-89	interleukin 10	Homo sapiens	27-32
30917314-6	2019	TNT formation requires the IL-10/STAT3 signaling pathway, and targeted inhibition of TNTs substantially reduces the enhancement of HIV-1 cell-to-cell transfer and overproduction in M(IL-10) macrophages.	tnts	85-89	interleukin 10	Homo sapiens	183-188
30632067-6	2019	Furthermore depletion of cholesterol and ionizing radiation as a stress factor results in a complete loss of Hsp70-containing TNTs.	tnts	126-130	heat shock protein 1B	Mus musculus	109-114
30305100-6	2018	Indeed, the GEF-H1 inactivation induced by RASSF1A silencing, leads to Rab11 accumulation and subsequent exosome releasing, which in turn contribute to TNTs formation.	tnts	152-156	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	12-18
30039805-7	2018	Selective transport-inhibition analysis of two abundant motor proteins in these cell types demonstrated that actin-based non-muscle myosin 2A dominantly mediates intercellular MV-transport via TNTs, in contrast to the microtubule-based dynein, as shown by the unchanged transport after inhibition of the latter.	tnts	193-197	myosin heavy chain 14	Homo sapiens	132-138
30305100-6	2018	Indeed, the GEF-H1 inactivation induced by RASSF1A silencing, leads to Rab11 accumulation and subsequent exosome releasing, which in turn contribute to TNTs formation.	tnts	152-156	Ras association domain family member 1	Homo sapiens	43-50
30305100-6	2018	Indeed, the GEF-H1 inactivation induced by RASSF1A silencing, leads to Rab11 accumulation and subsequent exosome releasing, which in turn contribute to TNTs formation.	tnts	152-156	RAB11A, member RAS oncogene family	Homo sapiens	71-76
30305100-8	2018	CONCLUSIONS: This finding suggests for the first time that loss of RASSF1A expression could be a potential biomarker for TNTs formation, such TNTs facilitating intercellular communication favoring multistep progression of bronchial epithelial cells toward overt malignancy.	tnts	121-125	Ras association domain family member 1	Homo sapiens	67-74
29056612-5	2018	To investigate this possibility, drug-loaded double-layer sol-gel coatings were fabricated on TiO2 nanotubes (TNTs), which were used to modulate the switch from the M1 to the M2 phenotype by controlled release of interleukin (IL)-4.	tnts	110-114	interleukin 4	Homo sapiens	213-231
30040092-6	2018	For the combination of AgCl and TNTs, the SPR effect of Ag0 formed by UV light irradiation improved the separation of electron-hole pairs which was proved by the electrochemistry impedance spectra.	tnts	32-36	sepiapterin reductase	Homo sapiens	42-45
29524297-3	2018	Here, we report the loading of an immunomodulatory cytokine,IL-4, into TiO2 nanotubes (TNTs) followed by hydrogel coating on the TNTs for subsequent release of IL-4.	tnts	87-91	interleukin 4	Homo sapiens	60-64
29765077-8	2018	We subsequently considered thrombin as a physiological inducer of endothelial TNTs because it reduces junctional contact.	tnts	78-82	coagulation factor II, thrombin	Homo sapiens	27-35
29089438-5	2017	The stressed astrocytes respond by conspicuously sending out TNTs, enabling intercellular transfer of alpha-SYN to healthy astrocytes, which in return deliver mitochondria, indicating a TNT-mediated rescue mechanism.	tnts	61-65	synuclein alpha	Homo sapiens	102-111
29208460-4	2018	These cells produces thin membrane protrusions that displayed the characteristics of actin rich tunneling nanotubes (TNTs) and here we show that RalGPS2 is involved in the formation of these cellular protrusions.	tnts	117-121	Ral GEF with PH domain and SH3 binding motif 2	Homo sapiens	145-152
29208460-6	2018	Moreover, using a series of RalA mutants impaired in the interaction with different downstream components (Sec5, Exo84, RalBP1) we demonstrated that the interaction of RalA with Sec5 is required for TNTs formation.	tnts	199-203	RAS like proto-oncogene A	Homo sapiens	28-32
29208460-6	2018	Moreover, using a series of RalA mutants impaired in the interaction with different downstream components (Sec5, Exo84, RalBP1) we demonstrated that the interaction of RalA with Sec5 is required for TNTs formation.	tnts	199-203	exocyst complex component 2	Homo sapiens	107-111
29208460-6	2018	Moreover, using a series of RalA mutants impaired in the interaction with different downstream components (Sec5, Exo84, RalBP1) we demonstrated that the interaction of RalA with Sec5 is required for TNTs formation.	tnts	199-203	exocyst complex component 8	Homo sapiens	113-118
29208460-6	2018	Moreover, using a series of RalA mutants impaired in the interaction with different downstream components (Sec5, Exo84, RalBP1) we demonstrated that the interaction of RalA with Sec5 is required for TNTs formation.	tnts	199-203	ralA binding protein 1	Homo sapiens	120-126
29208460-6	2018	Moreover, using a series of RalA mutants impaired in the interaction with different downstream components (Sec5, Exo84, RalBP1) we demonstrated that the interaction of RalA with Sec5 is required for TNTs formation.	tnts	199-203	RAS like proto-oncogene A	Homo sapiens	168-172
29208460-6	2018	Moreover, using a series of RalA mutants impaired in the interaction with different downstream components (Sec5, Exo84, RalBP1) we demonstrated that the interaction of RalA with Sec5 is required for TNTs formation.	tnts	199-203	exocyst complex component 2	Homo sapiens	178-182
29208460-7	2018	Furthermore, we found that RalGPS2 interacts with the transmembrane MHC class III protein leukocyte specific transcript 1 (LST1) and RalA, leading to the formation of a complex which promotes TNTs generation.	tnts	192-196	Ral GEF with PH domain and SH3 binding motif 2	Homo sapiens	27-34
29208460-7	2018	Furthermore, we found that RalGPS2 interacts with the transmembrane MHC class III protein leukocyte specific transcript 1 (LST1) and RalA, leading to the formation of a complex which promotes TNTs generation.	tnts	192-196	leukocyte specific transcript 1	Homo sapiens	90-121
29208460-7	2018	Furthermore, we found that RalGPS2 interacts with the transmembrane MHC class III protein leukocyte specific transcript 1 (LST1) and RalA, leading to the formation of a complex which promotes TNTs generation.	tnts	192-196	leukocyte specific transcript 1	Homo sapiens	123-127
29208460-7	2018	Furthermore, we found that RalGPS2 interacts with the transmembrane MHC class III protein leukocyte specific transcript 1 (LST1) and RalA, leading to the formation of a complex which promotes TNTs generation.	tnts	192-196	RAS like proto-oncogene A	Homo sapiens	133-137
29189162-11	2018	Drugs that inhibit TnT-formation such as metformin and everolimus can be targeted towards TnTs in the management of cancer growth, proliferation, tumor invasion and metastasis.	tnts	90-94	chromosome 16 open reading frame 82	Homo sapiens	19-22
29319002-3	2018	The novel MoS2 QDs@TNT photocatalysts showed excellent photocatalytic activity with a decolorization rate of 92% or approximately 3.5 times more than that of pure TNTs for the high initial concentration of methylene blue solution (20 mg l-1) within 40 min under visible-light irradiation.	tnts	163-167	troponin T1, slow skeletal type	Homo sapiens	19-22
29089438-11	2017	The stressed astrocytes respond by sending out TNTs, enabling intercellular transfer of alpha-SYN to healthy astrocytes.	tnts	47-51	synuclein alpha	Homo sapiens	88-97
28790434-8	2017	Interestingly we also detected a change in the ability of the osteoclast precursors to form tunneling nanotubes (TNTs), which suggests that MYO10 may regulate the presence of TNTs through its interaction with the cytoskeletal proteins.	tnts	113-117	myosin X	Homo sapiens	140-145
28819224-6	2017	We found that formation of TNTs required the activity and differential localization of Cdc42 and Rac1.	tnts	27-31	cell division cycle 42	Homo sapiens	87-92
28819224-6	2017	We found that formation of TNTs required the activity and differential localization of Cdc42 and Rac1.	tnts	27-31	Rac family small GTPase 1	Homo sapiens	97-101
28790434-8	2017	Interestingly we also detected a change in the ability of the osteoclast precursors to form tunneling nanotubes (TNTs), which suggests that MYO10 may regulate the presence of TNTs through its interaction with the cytoskeletal proteins.	tnts	175-179	myosin X	Homo sapiens	140-145
28423494-3	2017	In this study, we have identified TnTs in tumor cells derived from squamous cell carcinomas (SCC) cultured under bi-dimensional and tri-dimensional conditions and also in human SCC tissues.	tnts	34-38	serpin family B member 3	Homo sapiens	93-96
28423494-3	2017	In this study, we have identified TnTs in tumor cells derived from squamous cell carcinomas (SCC) cultured under bi-dimensional and tri-dimensional conditions and also in human SCC tissues.	tnts	34-38	serpin family B member 3	Homo sapiens	177-180
28423494-7	2017	Finally, FAK-deficient cells transfer lysosomes/autophagosomes to FAK-proficient cells via TnTs which may represent a novel mechanism to adapt to the stress elicited by impaired FAK signaling.	tnts	91-95	protein tyrosine kinase 2	Homo sapiens	9-12
28423494-7	2017	Finally, FAK-deficient cells transfer lysosomes/autophagosomes to FAK-proficient cells via TnTs which may represent a novel mechanism to adapt to the stress elicited by impaired FAK signaling.	tnts	91-95	protein tyrosine kinase 2	Homo sapiens	66-69
28423494-7	2017	Finally, FAK-deficient cells transfer lysosomes/autophagosomes to FAK-proficient cells via TnTs which may represent a novel mechanism to adapt to the stress elicited by impaired FAK signaling.	tnts	91-95	protein tyrosine kinase 2	Homo sapiens	66-69
28005071-7	2016	Meanwhile, downregulation of Rab8a or Rab11a in cultured SCs inhibited the formation of functional TNTs and vesicle transfer and led to decrease in cell migration, increase in SCs apoptosis.	tnts	99-103	RAB8A, member RAS oncogene family	Rattus norvegicus	29-34
27801976-6	2017	Although the TNT field is still in a nascent stage, we propose that TNTs can be investigated as novel targets for drug-based treatment of cancer and other diseases.	tnts	68-72	chromosome 16 open reading frame 82	Homo sapiens	13-16
28005071-9	2016	Overall, our results suggested that the gene of Rab8a or Rab11a might be involved in the formation of TNTs structures in the peripheral nerve system, while TNTs structures were likely to affect peripheral nerve regeneration through the regulation of neural cell communications.	tnts	102-106	RAB8A, member RAS oncogene family	Rattus norvegicus	48-53
28005071-7	2016	Meanwhile, downregulation of Rab8a or Rab11a in cultured SCs inhibited the formation of functional TNTs and vesicle transfer and led to decrease in cell migration, increase in SCs apoptosis.	tnts	99-103	RAB11a, member RAS oncogene family	Rattus norvegicus	38-44
28005071-9	2016	Overall, our results suggested that the gene of Rab8a or Rab11a might be involved in the formation of TNTs structures in the peripheral nerve system, while TNTs structures were likely to affect peripheral nerve regeneration through the regulation of neural cell communications.	tnts	102-106	RAB11a, member RAS oncogene family	Rattus norvegicus	57-63
28005071-9	2016	Overall, our results suggested that the gene of Rab8a or Rab11a might be involved in the formation of TNTs structures in the peripheral nerve system, while TNTs structures were likely to affect peripheral nerve regeneration through the regulation of neural cell communications.	tnts	156-160	RAB8A, member RAS oncogene family	Rattus norvegicus	48-53
26297738-6	2015	A combination of TNT-disrupting conditions allows us to analyze the functional importance of TNTs in an ex vivo model.	tnts	93-97	chromosome 16 open reading frame 82	Homo sapiens	17-20
27809932-4	2016	We show that the microtubule-associated protein Tau, a key player in Alzheimer"s disease, is a bona fide constituent of TNTs.	tnts	120-124	microtubule associated protein tau	Homo sapiens	17-51
26808243-2	2016	In this study, with titanate nanotubes (TNTs) as catalyst support, a novel CoFe2O4/TNTs hybrid was constructed by an impregnation-calcination method.	tnts	40-44	troponin T1, slow skeletal type	Homo sapiens	75-87
27550960-4	2016	Following transfer through TNTs, alpha-synuclein fibrils are able to seed soluble alpha-synuclein aggregation in the cytosol of acceptor cells.	tnts	27-31	synuclein alpha	Homo sapiens	33-48
27550960-4	2016	Following transfer through TNTs, alpha-synuclein fibrils are able to seed soluble alpha-synuclein aggregation in the cytosol of acceptor cells.	tnts	27-31	synuclein alpha	Homo sapiens	82-97
26090090-3	2015	Specifically, we hypothesize that TNTs can influence cell proliferation of preosteoblasts through cell adhesion and related modulation of FAK and RhoA.	tnts	34-38	PTK2 protein tyrosine kinase 2	Mus musculus	138-141
26172304-10	2015	TNTs-like structure and exosomes supply the routes for the transfer of TDP-43 aggregates, and selective inhibition of their over-generations may interrupt the progression of TDP-43 proteinopathy.	tnts	0-4	TAR DNA binding protein	Homo sapiens	71-77
26090090-3	2015	Specifically, we hypothesize that TNTs can influence cell proliferation of preosteoblasts through cell adhesion and related modulation of FAK and RhoA.	tnts	34-38	ras homolog family member A	Mus musculus	146-150
26090090-7	2015	The expression of FAK was 86.2% down regulated superimposition of TNTs topography.	tnts	66-70	PTK2 protein tyrosine kinase 2	Mus musculus	18-21
26090090-11	2015	These findings not only support our hypothesis, but suggest that RhoA might be critically involved in TNTs mediated cell proliferation.	tnts	102-106	ras homolog family member A	Mus musculus	65-69
25130443-5	2014	RESULTS: We found Rab11 and tetraspanins, especially CD81, all along T-cells TNTs, whereas Rab4 and Rab35 were absent from these structures.	tnts	77-81	RAB11A, member RAS oncogene family	Homo sapiens	18-23
25186209-3	2015	Upon coculture with cystinotic fibroblasts, macrophages produced tunneling nanotubes (TNTs) allowing transfer of cystinosin-bearing lysosomes into Ctns-deficient cells, which exploited the same route to retrogradely transfer cystine-loaded lysosomes to macrophages, providing a bidirectional correction mechanism.	tnts	86-90	cystinosin, lysosomal cystine transporter	Homo sapiens	113-123
25186209-3	2015	Upon coculture with cystinotic fibroblasts, macrophages produced tunneling nanotubes (TNTs) allowing transfer of cystinosin-bearing lysosomes into Ctns-deficient cells, which exploited the same route to retrogradely transfer cystine-loaded lysosomes to macrophages, providing a bidirectional correction mechanism.	tnts	86-90	cystinosin, lysosomal cystine transporter	Homo sapiens	147-151
25130443-5	2014	RESULTS: We found Rab11 and tetraspanins, especially CD81, all along T-cells TNTs, whereas Rab4 and Rab35 were absent from these structures.	tnts	77-81	CD81 molecule	Homo sapiens	53-57
24929208-6	2014	miR-19a was also transported via TnTs connecting transfected K7M2 cells and nontransfected stromal MC3T3 murine osteoblast cells.	tnts	33-37	microRNA 19a	Mus musculus	0-7
24936158-3	2014	The experimental results show that the CdS QD-sensitized TNTs (CdS/TNTs) do not only increase the light absorption of the P3HT:PCBM layer but also reduce the charge recombination in the P3HT:PCBM layer.	tnts	57-61	CDP-diacylglycerol synthase 1	Homo sapiens	63-66
24936158-3	2014	The experimental results show that the CdS QD-sensitized TNTs (CdS/TNTs) do not only increase the light absorption of the P3HT:PCBM layer but also reduce the charge recombination in the P3HT:PCBM layer.	tnts	67-71	CDP-diacylglycerol synthase 1	Homo sapiens	39-42
24936158-1	2014	We report that the efficiency of ITO/nc-TiO2/P3HT:PCBM/MoO3/Ag inverted polymer solar cells (PSCs) can be improved by dispersing CdS quantum dot (QD)-sensitized TiO2 nanotube arrays (TNTs) in poly (3-hexylthiophene) and [6,6]-phenyl-C61-butyric acid methyl ester (P3HT:PCBM) layer.	tnts	183-187	CDP-diacylglycerol synthase 1	Homo sapiens	129-132
24936158-2	2014	The CdS QDs are deposited on the TNTs by a chemical bath deposition method.	tnts	33-37	CDP-diacylglycerol synthase 1	Homo sapiens	4-7
24936158-3	2014	The experimental results show that the CdS QD-sensitized TNTs (CdS/TNTs) do not only increase the light absorption of the P3HT:PCBM layer but also reduce the charge recombination in the P3HT:PCBM layer.	tnts	67-71	CDP-diacylglycerol synthase 1	Homo sapiens	63-66
24936158-3	2014	The experimental results show that the CdS QD-sensitized TNTs (CdS/TNTs) do not only increase the light absorption of the P3HT:PCBM layer but also reduce the charge recombination in the P3HT:PCBM layer.	tnts	57-61	CDP-diacylglycerol synthase 1	Homo sapiens	39-42
24936158-4	2014	The dependence of device performances on cycles of CdS deposition on the TNTs was investigated.	tnts	73-77	CDP-diacylglycerol synthase 1	Homo sapiens	51-54
24936158-5	2014	A high power conversion efficiency (PCE) of 3.52% was achieved for the inverted PSCs with 20 cyclic depositions of CdS on TNTs, which showed a 34% increase compared to the ITO/nc-TiO2/P3HT:PCBM/MoO3/Ag device without the CdS/TNTs.	tnts	122-126	CDP-diacylglycerol synthase 1	Homo sapiens	115-118
24936158-5	2014	A high power conversion efficiency (PCE) of 3.52% was achieved for the inverted PSCs with 20 cyclic depositions of CdS on TNTs, which showed a 34% increase compared to the ITO/nc-TiO2/P3HT:PCBM/MoO3/Ag device without the CdS/TNTs.	tnts	225-229	CDP-diacylglycerol synthase 1	Homo sapiens	115-118
22222095-4	2012	TNTs and TiO2 nanoparticles were coated onto FTO glass by the screen printing method.	tnts	0-4	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	45-48
23886947-3	2013	Here, we study the role of the unconventional molecular motor myosin-X (Myo10) in the formation of functional TNTs within neuronal CAD cells.	tnts	110-114	myosin X	Homo sapiens	62-70
23886947-3	2013	Here, we study the role of the unconventional molecular motor myosin-X (Myo10) in the formation of functional TNTs within neuronal CAD cells.	tnts	110-114	myosin X	Homo sapiens	72-77
23868059-5	2013	Next, we determined by measuring fluorescence recovery after photobleaching that GFP-H-Ras diffuses freely in the membrane of TNTs that form spontaneously between B and T cells during coculturing.	tnts	126-130	HRas proto-oncogene, GTPase	Homo sapiens	81-90
23868059-6	2013	Importantly, by 4D time-lapse imaging, we showed that GFP-H-Ras-enriched PM patches accumulate at the junction between TNTs and the T-cell body and subsequently transfer to the T-cell surface.	tnts	119-123	HRas proto-oncogene, GTPase	Homo sapiens	54-63
23868059-9	2013	In summary, our data indicate that TNTs connecting B and T cells provide a hitherto undescribed route for the transfer of PM patches containing, for example, H-Ras from B to T cells.	tnts	35-39	HRas proto-oncogene, GTPase	Homo sapiens	158-163
23623413-1	2013	Unlike the complex reaction of grafting amino groups using harmful organic solvents, we proposed an environmental friendly method for effective amino grafting on titanate nanotubes (TNTs) with 2-Bromoethylamine hydrobromide (2-Bh) through a two-step SN2 reaction in pure water solution.	tnts	182-186	solute carrier family 38 member 5	Homo sapiens	250-253
23623413-4	2013	The adsorption isotherm of Cr(VI) onto TNTs-RNH2 well fits Langmuir model with maximal adsorption capacity of 69.1 mg/g, which is almost five times larger than that of fresh TNTs.	tnts	39-43	NLR family pyrin domain containing 4	Homo sapiens	44-48
23623413-6	2013	The wide adsorption pH range was due to much larger point of zero charge (8.2) and electrostatic attraction between positively charged TNTs-RNH2 and Cr(VI) with different speciations.	tnts	135-139	NLR family pyrin domain containing 4	Homo sapiens	140-144
24759528-8	2014	The results showed that the yield of hydrogen with CdS/TNTs + WO3 was much higher than with CdS/TiO2 + WO3.	tnts	55-59	CDP-diacylglycerol synthase 1	Homo sapiens	51-54
23229356-6	2013	These studies have revealed key molecules for their induction and/or formation; HIV Nef and M-Sec can induce the formation of TNTs in coordination with the remodeling of the actin cytoskeleton and vesicle trafficking.	tnts	126-130	S100 calcium binding protein B	Homo sapiens	84-87
22103195-5	2011	The ion-exchanged TNT showed the highest photocatalytic activity among the TNTs tested in this study, but it was lower than that of P25.	tnts	75-79	chromosome 16 open reading frame 82	Homo sapiens	18-21
22457742-17	2012	Immunolabelling for Cx43 showed that this gap junction protein is interposed at one end of 44% of TNTs between ARPE-19 cells.	tnts	98-102	gap junction protein alpha 1	Homo sapiens	20-24
16474882-1	2005	TiO2 nanotubes (TNTs) with large aspect ratio and large specific surface area were prepared from P25 (Nippon Aerosil) and applied to dye-sensitized titanium dioxide solar cells (DSSCs).	tnts	16-20	tubulin polymerization promoting protein	Homo sapiens	97-100
20855598-6	2010	Several lines of evidence implicate a role for gap junctions in this long-distance electrical coupling: punctate connexin 43 immunoreactivity was frequently detected at one end of TNTs, and electrical coupling was voltage-sensitive and inhibited by meclofenamic acid, a gap-junction blocker.	tnts	180-184	gap junction protein, alpha 1	Rattus norvegicus	113-124
19198598-4	2009	Here we show that TNTs allow transfer of exogenous and endogenous PrP(Sc) between infected and naive neuronal CAD cells.	tnts	18-22	prion protein	Mus musculus	66-69
19198598-5	2009	Significantly, transfer of endogenous PrP(Sc) aggregates was detected exclusively when cells chronically infected with the 139A mouse prion strain were connected to mouse CAD cells by means of TNTs, identifying TNTs as an efficient route for PrP(Sc) spreading in neuronal cells.	tnts	193-197	prion protein	Mus musculus	38-41
19198598-5	2009	Significantly, transfer of endogenous PrP(Sc) aggregates was detected exclusively when cells chronically infected with the 139A mouse prion strain were connected to mouse CAD cells by means of TNTs, identifying TNTs as an efficient route for PrP(Sc) spreading in neuronal cells.	tnts	193-197	prion protein	Mus musculus	242-245
19198598-5	2009	Significantly, transfer of endogenous PrP(Sc) aggregates was detected exclusively when cells chronically infected with the 139A mouse prion strain were connected to mouse CAD cells by means of TNTs, identifying TNTs as an efficient route for PrP(Sc) spreading in neuronal cells.	tnts	211-215	prion protein	Mus musculus	38-41
19198598-5	2009	Significantly, transfer of endogenous PrP(Sc) aggregates was detected exclusively when cells chronically infected with the 139A mouse prion strain were connected to mouse CAD cells by means of TNTs, identifying TNTs as an efficient route for PrP(Sc) spreading in neuronal cells.	tnts	211-215	prion protein	Mus musculus	242-245
19198598-6	2009	In addition, we detected the transfer of labelled PrP(Sc) from bone marrow-derived dendritic cells to primary neurons connected through TNTs.	tnts	136-140	prion protein	Mus musculus	50-53
19198598-8	2009	We therefore propose that TNTs are involved in the spreading of PrP(Sc) within neurons in the CNS and from the peripheral site of entry to the PNS by neuroimmune interactions with dendritic cells.	tnts	26-30	prion protein	Mus musculus	64-67
16474882-3	2005	The evaluation of dye adsorption and the photo-injected electron transport such as electron diffusion coefficient (D) and electron lifetime (tau) in TNTs electrodes revealed that the higher efficiency resulted from increase of electron density with keeping much longer tau in TNTs electrodes than in P25 electrodes.	tnts	149-153	tubulin polymerization promoting protein	Homo sapiens	300-303
16474882-3	2005	The evaluation of dye adsorption and the photo-injected electron transport such as electron diffusion coefficient (D) and electron lifetime (tau) in TNTs electrodes revealed that the higher efficiency resulted from increase of electron density with keeping much longer tau in TNTs electrodes than in P25 electrodes.	tnts	276-280	tubulin polymerization promoting protein	Homo sapiens	300-303