PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32683181-4	2020	We successfully engineered high affinity ERRalpha agonism into a chemical scaffold that displays selective ERRbeta/gamma agonist activity (GSK4716), providing novel ERRalpha/beta/gamma pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors.	GSK 4716	139-146	estrogen related receptor alpha	Homo sapiens	41-49
33612148-5	2021	Interestingly, GSK5182 increased ERRgamma protein levels much as does GSK4716, which is an ERRgamma agonist.	GSK 4716	70-77	estrogen related receptor gamma	Homo sapiens	91-99
32897058-5	2020	Here, we describe a novel dual ERRalpha/gamma inverse agonist, SLU-PP-1072, derived from the GSK4716 ERRgamma agonist scaffold that is distinct from the XCT790 scaffold.	GSK 4716	93-100	estrogen related receptor alpha	Homo sapiens	31-39
32897058-5	2020	Here, we describe a novel dual ERRalpha/gamma inverse agonist, SLU-PP-1072, derived from the GSK4716 ERRgamma agonist scaffold that is distinct from the XCT790 scaffold.	GSK 4716	93-100	estrogen related receptor gamma	Homo sapiens	101-109
32683181-4	2020	We successfully engineered high affinity ERRalpha agonism into a chemical scaffold that displays selective ERRbeta/gamma agonist activity (GSK4716), providing novel ERRalpha/beta/gamma pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors.	GSK 4716	139-146	estrogen related receptor alpha	Homo sapiens	107-120
32683181-4	2020	We successfully engineered high affinity ERRalpha agonism into a chemical scaffold that displays selective ERRbeta/gamma agonist activity (GSK4716), providing novel ERRalpha/beta/gamma pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors.	GSK 4716	139-146	estrogen related receptor alpha	Homo sapiens	165-178
32173553-5	2020	The ERRgamma agonist GSK4716 increased DAT and TH expression, and the ERRgamma inverse agonist GSK5182 attenuated the retinoic acid-induced upregulation of DAT and TH in differentiated SH-SY5Y cells.	GSK 4716	21-28	tyrosine hydroxylase	Homo sapiens	47-49
32173553-0	2020	Regulation of dopaminergic neuronal phenotypes by the estrogen-related receptor gamma ligand GSK4716 via the activation of CREB signaling.	GSK 4716	93-100	estrogen related receptor gamma	Homo sapiens	54-85
32173553-5	2020	The ERRgamma agonist GSK4716 increased DAT and TH expression, and the ERRgamma inverse agonist GSK5182 attenuated the retinoic acid-induced upregulation of DAT and TH in differentiated SH-SY5Y cells.	GSK 4716	21-28	solute carrier family 6 member 3	Homo sapiens	156-159
32173553-0	2020	Regulation of dopaminergic neuronal phenotypes by the estrogen-related receptor gamma ligand GSK4716 via the activation of CREB signaling.	GSK 4716	93-100	cAMP responsive element binding protein 1	Homo sapiens	123-127
32173553-5	2020	The ERRgamma agonist GSK4716 increased DAT and TH expression, and the ERRgamma inverse agonist GSK5182 attenuated the retinoic acid-induced upregulation of DAT and TH in differentiated SH-SY5Y cells.	GSK 4716	21-28	tyrosine hydroxylase	Homo sapiens	164-166
32173553-5	2020	The ERRgamma agonist GSK4716 increased DAT and TH expression, and the ERRgamma inverse agonist GSK5182 attenuated the retinoic acid-induced upregulation of DAT and TH in differentiated SH-SY5Y cells.	GSK 4716	21-28	solute carrier family 6 member 3	Homo sapiens	39-42
32173553-6	2020	We found that biphasic activation of the protein kinase A/cyclic AMP response element-binding (CREB) protein signaling pathway was involved in the GSK4716-induced increase in the DAergic phenotype in SH-SY5Y cells.	GSK 4716	147-154	cAMP responsive element binding protein 1	Homo sapiens	95-99
32173553-7	2020	CREB signaling activated as early as 3 h after GSK4716 treatment in an ERRgamma-independent manner, but increased following ERRgamma activation after 3 days.	GSK 4716	47-54	cAMP responsive element binding protein 1	Homo sapiens	0-4
32173553-8	2020	Protein kinase A inhibitor H-89 attenuated GSK4716-induced DAT and TH upregulation.	GSK 4716	43-50	solute carrier family 6 member 3	Homo sapiens	59-62
32173553-9	2020	In primary cultured DAergic neurons, GSK4716 increased neurite length and the number of DAT and TH-double-positive (DAT+TH+) neurons compared to that in control cells.	GSK 4716	37-44	solute carrier family 6 member 3	Homo sapiens	88-91
32173553-9	2020	In primary cultured DAergic neurons, GSK4716 increased neurite length and the number of DAT and TH-double-positive (DAT+TH+) neurons compared to that in control cells.	GSK 4716	37-44	solute carrier family 6 member 3	Homo sapiens	116-119
31491697-5	2019	All of the tested chemicals could bind to ERRgamma with the Kd (dissociation constant) values ranging from not available (NA) to 3.2 muM 4"-OH-PCB 12 showed the highest binding affinity with Kd value of 3.2 muM, which was comparable to that of a synthetic ERRgamma agonist GSK4716.	GSK 4716	273-280	estrogen related receptor gamma	Homo sapiens	42-50
22457827-7	2012	Conversely, stimulation of ERRbeta with a selective agonist (GSK4716) in a TAL cell line stimulated NKCC2 expression.	GSK 4716	61-68	estrogen related receptor, beta	Mus musculus	27-34
22457827-7	2012	Conversely, stimulation of ERRbeta with a selective agonist (GSK4716) in a TAL cell line stimulated NKCC2 expression.	GSK 4716	61-68	solute carrier family 12, member 1	Mus musculus	100-105
19631715-2	2010	Natural ligands have not been identified, however, recent reports have demonstrated the synthetic phenolic acyl hydrazone, GSK4716, functions as a selective ERRbeta/gamma agonist.	GSK 4716	123-130	estrogen related receptor beta	Homo sapiens	157-170
19631715-4	2010	Treatment of differentiated skeletal muscle cells with the ERRbeta/gamma agonist (GSK4716) produced a significant increase in the expression of GRalpha (isoform D) protein.	GSK 4716	82-89	estrogen related receptor beta	Homo sapiens	59-72
16990259-7	2006	The observed agonist-bound state contains the ERRgamma LBD, a ligand (GSK4716), and the RIP140 peptide and reveals an unexpected rearrangement of the phenol-binding residues.	GSK 4716	70-77	estrogen related receptor gamma	Homo sapiens	46-54
18776219-9	2008	In addition, the ERRgamma agonist GSK4716 induced miR-433 and miR-127 expression both in vitro and in vivo, respectively.	GSK 4716	34-41	microRNA 433	Mus musculus	50-57
18776219-9	2008	In addition, the ERRgamma agonist GSK4716 induced miR-433 and miR-127 expression both in vitro and in vivo, respectively.	GSK 4716	34-41	microRNA 127	Mus musculus	62-69
16990259-7	2006	The observed agonist-bound state contains the ERRgamma LBD, a ligand (GSK4716), and the RIP140 peptide and reveals an unexpected rearrangement of the phenol-binding residues.	GSK 4716	70-77	nuclear receptor interacting protein 1	Homo sapiens	88-94
16990259-9	2006	In contrast to the conventional mechanism of nuclear receptor ligand activation, activation of ERRgamma by GSK4716 does not appear to involve a major rearrangement or significant stabilization of the C-terminal helix.	GSK 4716	107-114	estrogen related receptor gamma	Homo sapiens	95-103
15857113-2	2005	GSK4716 (3) and GSK9089 (4) show binding to ERRgamma with remarkable selectivity over the classical estrogen receptors.	GSK 4716	0-7	estrogen related receptor gamma	Homo sapiens	44-52
16515477-7	2006	The phenolic acyl hydrazones GSK4716 and GSK9089 act as selective agonists of ERRbeta and ERRgamma.	GSK 4716	29-36	estrogen related receptor beta	Homo sapiens	78-85
16515477-7	2006	The phenolic acyl hydrazones GSK4716 and GSK9089 act as selective agonists of ERRbeta and ERRgamma.	GSK 4716	29-36	estrogen related receptor gamma	Homo sapiens	90-98