PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18388203-10	2008	The chemical insights gleaned from this work pave the foundation toward defining the molecular rules for the ARO/CYC cyclization specificity, whose rational control will be important for future endeavors in the engineered biosynthesis of novel anticancer and antibiotic aromatic polyketides.	Polyketides	279-290	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	109-112
18388203-10	2008	The chemical insights gleaned from this work pave the foundation toward defining the molecular rules for the ARO/CYC cyclization specificity, whose rational control will be important for future endeavors in the engineered biosynthesis of novel anticancer and antibiotic aromatic polyketides.	Polyketides	279-290	cytochrome c, somatic	Homo sapiens	113-116
17804731-4	2007	Here, using the potent ACC inhibitor soraphen A, a macrocyclic polyketide from myxobacteria, we show that ACC activity in cancer cells is essential for proliferation and survival.	Polyketides	63-73	acetyl-CoA carboxylase alpha	Homo sapiens	106-109
18855960-0	2008	Sequential asymmetric polyketide heterocyclization catalyzed by a single cytochrome P450 monooxygenase (AurH).	Polyketides	22-32	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	73-102
18059524-4	2007	Additionally, ACP homologues are key components in the production of secondary metabolites such as polyketides and nonribosomal peptides.	Polyketides	99-110	acyl carrier protein	Saccharomyces cerevisiae S288C	14-17
18283606-3	2008	New functions for PKS domains continue to be defined, such as the general control nonderepressible 5 (GCN5) N-acyltransferase strategy for polyketide chain initiation and the true identity of the elusive precursor for the methoxymalonylate extender unit.	Polyketides	139-149	lysine acetyltransferase 2A	Homo sapiens	66-100
18283606-3	2008	New functions for PKS domains continue to be defined, such as the general control nonderepressible 5 (GCN5) N-acyltransferase strategy for polyketide chain initiation and the true identity of the elusive precursor for the methoxymalonylate extender unit.	Polyketides	139-149	lysine acetyltransferase 2A	Homo sapiens	102-106
18065542-0	2008	A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra.	Polyketides	86-96	two component system response transcriptional positive regulator PhoP	Mycobacterium tuberculosis H37Rv	48-52
17620609-5	2007	Using rounds of mutagenesis coupled with in vivo screens for NRP production, we rapidly isolated variants of two different chimeric NRPSs with approximately 10-fold improvements in enzyme activity and product yield, including one that produces new derivatives of the potent NRP/polyketide antibiotic andrimid.	Polyketides	278-288	neuropilin 1	Homo sapiens	61-64
17620609-5	2007	Using rounds of mutagenesis coupled with in vivo screens for NRP production, we rapidly isolated variants of two different chimeric NRPSs with approximately 10-fold improvements in enzyme activity and product yield, including one that produces new derivatives of the potent NRP/polyketide antibiotic andrimid.	Polyketides	278-288	neuropilin 1	Homo sapiens	132-135
17049224-4	2006	First, substantial advances have been made in the development of inhibitors based on immunophilin ligand polyketides, which target the TOR-mediated pathways and can modulate processes including cell proliferation and cell-cycle arrest.	Polyketides	105-116	RAR related orphan receptor C	Homo sapiens	135-138
17482575-1	2007	As part of the pksX gene cluster of Bacillus subtilis strain 168, pksS has been preliminarily annotated as a cytochrome P450 homolog that hydroxylates the polyketide product of this cluster, which was recently shown to be involved in the biosynthesis of bacillaene and dihydrobacillaene.	Polyketides	155-165	cytochrome P450 of bacillaene metabolism	Bacillus subtilis subsp. subtilis str. 168	66-70
17488037-2	2007	The synthesis of the polyketide template utilized a diastereoselective syn-aldol, ortho-ester Claisen rearrangement followed by efficient conversion to a cyanide.	Polyketides	21-31	synemin	Homo sapiens	4-7
17518432-8	2007	This comparative discovery suggests that a cyclic peptide polyketide bridge, like that found in FK506 and rapamycin or a similar linkage, may significantly improve the binding affinity of structure-based Pin1 inhibitors.	Polyketides	58-68	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	204-208
16983083-9	2006	This evidence shows the formation of ACP-linked extender units for polyketide synthesis.	Polyketides	67-77	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	37-40
17312955-2	2006	The difficulties encountered in the synthesis of these series of polyketides are highlighted by the fact that only one total synthesis of PTX4 and PTX8 has been completed to date.	Polyketides	65-76	pentraxin 4	Homo sapiens	138-142
15611286-0	2004	Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells.	Polyketides	50-60	CD1c molecule	Homo sapiens	74-78
12183690-1	2002	The polyketides FK506 (tacrolimus) and FK520 (ascomycin) are potent immunosuppressants that function by inhibiting calcineurin phosphatase through formation of an FKBP12-FK506/520-calcineurin ternary complex.	Polyketides	4-15	FKBP prolyl isomerase 1A	Rattus norvegicus	163-169
15231999-9	2004	A Paterson anti-aldol process was used to incorporate the remaining two ketide stereogenic centers at C34 and C35.	Polyketides	72-78	migration and invasion enhancer 1	Homo sapiens	110-113
12696864-4	2003	Regardless of the stereochemistry, these C-glycosides served as acceptor for a subsequent glycosylation step to yield the novel urdamycins R and S with di-rhodinosyl side chains at C-9 of the polyketide moiety.	Polyketides	192-202	complement C9	Homo sapiens	181-184
11121076-0	2000	Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.	Polyketides	70-80	ATP synthase F1 subunit epsilon	Homo sapiens	95-110
11403625-0	2001	Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors.	Polyketides	112-122	acyl-CoA synthetase family member 3	Homo sapiens	40-62
11121076-1	2000	Recently, a family of polyketide inhibitors of F(0)F(1)-ATPase, including apoptolidin, ossamycin, and oligomycin, were shown to be among the top 0.1% most cell line selective cytotoxic agents of 37, 000 molecules tested against the 60 human cancer cell lines of the National Cancer Institute.	Polyketides	22-32	ATP synthase F1 subunit epsilon	Homo sapiens	47-62
10684659-4	2000	In the presence of an acyl carrier protein (ACP) and a malonyl-CoA:ACP malonyl transferase (MAT), this enzyme synthesizes a polyketide chain of defined length from malonyl-CoA.	Polyketides	124-134	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	22-42
10684659-4	2000	In the presence of an acyl carrier protein (ACP) and a malonyl-CoA:ACP malonyl transferase (MAT), this enzyme synthesizes a polyketide chain of defined length from malonyl-CoA.	Polyketides	124-134	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	44-47
10684659-4	2000	In the presence of an acyl carrier protein (ACP) and a malonyl-CoA:ACP malonyl transferase (MAT), this enzyme synthesizes a polyketide chain of defined length from malonyl-CoA.	Polyketides	124-134	acetyl-CoA acetyltransferase 1	Homo sapiens	55-90
10684659-4	2000	In the presence of an acyl carrier protein (ACP) and a malonyl-CoA:ACP malonyl transferase (MAT), this enzyme synthesizes a polyketide chain of defined length from malonyl-CoA.	Polyketides	124-134	acetyl-CoA acetyltransferase 1	Homo sapiens	92-95
10684659-9	2000	Malonyl-ACP alone is sufficient for kinetically and stoichiometrically efficient synthesis of polyketides by the wild-type KS-CLF, but not by heterodimers that carry the mutations listed above.	Polyketides	94-105	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	8-11
10684659-12	2000	A model is proposed for decarboxylative priming and extension of a polyketide chain by the KS, where C169 and H346 form a catalytic dyad for acyl chain attachment, H309 positions the malonyl-ACP in the active site and supports carbanion formation by interacting with the thioester carbonyl, and K341 enhances the rate of malonyl-ACP decarboxylation via electrostatic interaction.	Polyketides	67-77	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	191-194
10684659-12	2000	A model is proposed for decarboxylative priming and extension of a polyketide chain by the KS, where C169 and H346 form a catalytic dyad for acyl chain attachment, H309 positions the malonyl-ACP in the active site and supports carbanion formation by interacting with the thioester carbonyl, and K341 enhances the rate of malonyl-ACP decarboxylation via electrostatic interaction.	Polyketides	67-77	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	329-332
9219693-1	1997	A genetic block was introduced in the first condensation step of the polyketide biosynthetic pathway that leads to the formation of 6-deoxyerythronolide B (6-dEB), the macrocyclic precursor of erythromycin.	Polyketides	69-79	DebC	Drosophila melanogaster	158-161
9863632-11	1998	Tautomycin, a polyketide produced by the soil bacteria Streptomyces which inhibits serine/threonine phosphatases of the PP1/PP2A subgroup, was able to inhibit the endogenous phosphatase activity in a concentration-dependent form (Ki(app)=7.35 nM).	Polyketides	14-24	neuropeptide Y receptor Y4	Rattus norvegicus	120-123
9485401-8	1998	Both of these hybrid proteins supported polyketide synthesis, suggesting that AT2 can perform its function from either subunit.	Polyketides	40-50	angiotensin II receptor type 2	Homo sapiens	78-81
9219693-2	1997	Exogenous addition of designed synthetic molecules to small-scale cultures of this null mutant resulted in highly selective multimilligram production of unnatural polyketides, including aromatic and ring-expanded variants of 6-dEB.	Polyketides	163-174	DebC	Drosophila melanogaster	227-230
8823171-7	1996	Remarkably however, the KS-1/KS-2 and the KS-2/ACP-2 mutant pairs could efficiently complement each other and catalyze polyketide formation.	Polyketides	119-129	zinc finger protein 382	Homo sapiens	24-28
8823171-7	1996	Remarkably however, the KS-1/KS-2 and the KS-2/ACP-2 mutant pairs could efficiently complement each other and catalyze polyketide formation.	Polyketides	119-129	acid phosphatase 2, lysosomal	Homo sapiens	47-52
8823171-12	1996	Finally, blocked systems, such as the KS-1 mutant described here, present a new strategy for the noncompetitive conversion of unnatural substrates into polyketides by modular PKSs.	Polyketides	152-163	zinc finger protein 382	Homo sapiens	38-42
34142621-0	2022	Alternatones A and B, two polyketides possessing novel skeletons from entophyte Alternaria alternate L-10.	Polyketides	26-37	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	101-105
8149967-2	1994	Screening of microbial metabolites for CD4-binding activity using an enzyme-linked immunosorbent assay based on the binding of the CD4-specific monoclonal antibody (mAb), anti-Leu3a, identified a family of compounds comprising several novel polyketides.	Polyketides	241-252	CD4 molecule	Homo sapiens	39-42
8149967-2	1994	Screening of microbial metabolites for CD4-binding activity using an enzyme-linked immunosorbent assay based on the binding of the CD4-specific monoclonal antibody (mAb), anti-Leu3a, identified a family of compounds comprising several novel polyketides.	Polyketides	241-252	CD4 molecule	Homo sapiens	131-134
34657428-1	2021	The total synthesis of geldanamycin, a well-known polyketide that exhibited potent anticancer activity by inhibiting Hsp90, was finished in 26 long linear steps with 2.65% overall yield.	Polyketides	50-60	heat shock protein 90 alpha family class A member 1	Homo sapiens	117-122
34142621-1	2022	On our ongoing searching for bioactive natural products derived from entophytes, two polyketides possessing novel skeletons, alternatones A-B (1-2), were identified from the culture of Alternaria alternate L-10.	Polyketides	85-96	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	206-210
32572277-4	2020	Using chemoproteomic platforms, we show that members of the manumycin family of polyketides, which bear multiple potentially reactive sites, target C374 of the putative E3 ligase UBR7 in breast cancer cells, and engage in molecular glue interactions with the neosubstrate tumor-suppressor TP53, leading to p53 transcriptional activation and cell death.	Polyketides	80-91	ubiquitin protein ligase E3 component n-recognin 7	Homo sapiens	179-183
34636382-1	2022	Correction for "Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis" by Rory F. Little et al., Nat.	Polyketides	44-54	bromodomain containing 2	Homo sapiens	121-124
35524051-0	2022	Engineering Modular Polyketide Biosynthesis in Streptomyces Using CRISPR/Cas: A Practical Guide.	Polyketides	20-30	BCAR1 scaffold protein, Cas family member	Homo sapiens	73-76
33006801-4	2021	The macrocyclic polyketide compounds exhibited wide-spectrum of anti-infective potential against clinically significant vancomycin-resistant Enterococcus faecalis (VREfs), methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Klebsiella pneumonia with minimum inhibitory concentration of about 1-3 microg mL-1 , insomuch as the antibiotics chloramphenicol and ampicillin were active at >= 6.25 microg mL-1 .	Polyketides	16-26	L1 cell adhesion molecule	Mus musculus	331-335
33006801-4	2021	The macrocyclic polyketide compounds exhibited wide-spectrum of anti-infective potential against clinically significant vancomycin-resistant Enterococcus faecalis (VREfs), methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Klebsiella pneumonia with minimum inhibitory concentration of about 1-3 microg mL-1 , insomuch as the antibiotics chloramphenicol and ampicillin were active at >= 6.25 microg mL-1 .	Polyketides	16-26	L1 cell adhesion molecule	Mus musculus	427-431
35293722-7	2022	This study clearly establishes the NphE reaction product 8-AF as a common intermediate with a cryptic amino group for the biosynthesis of terpenoid-polyketide hybrid natural products.	Polyketides	148-158	cripto, FRL-1, cryptic family 1	Homo sapiens	94-101
32572277-4	2020	Using chemoproteomic platforms, we show that members of the manumycin family of polyketides, which bear multiple potentially reactive sites, target C374 of the putative E3 ligase UBR7 in breast cancer cells, and engage in molecular glue interactions with the neosubstrate tumor-suppressor TP53, leading to p53 transcriptional activation and cell death.	Polyketides	80-91	tumor protein p53	Homo sapiens	289-293
32572277-4	2020	Using chemoproteomic platforms, we show that members of the manumycin family of polyketides, which bear multiple potentially reactive sites, target C374 of the putative E3 ligase UBR7 in breast cancer cells, and engage in molecular glue interactions with the neosubstrate tumor-suppressor TP53, leading to p53 transcriptional activation and cell death.	Polyketides	80-91	tumor protein p53	Homo sapiens	306-309
27653519-1	2016	In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elongation, cyclization and product release.	Polyketides	23-33	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	57-77
31489170-4	2019	This method was applied to the synthesis of the C1-9 fragment of a polyketide natural product, mycinolide IV.	Polyketides	67-77	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	48-52
31045379-1	2019	Stereoselective tandem synthesis of syn-1,3-diol motifs, abundantly present in polyketide natural products and relevant pharmaceuticals, was achieved from homoallylic alcohols, alpha,beta-unsaturated ketones, and aldehydes.	Polyketides	79-89	synapsin I	Homo sapiens	36-41
32999280-2	2020	In the screen for bioactive inhibitors of the Otub1/c-Maf axis for MM treatment, nanchangmycin (Nam), a polyketide antibiotic, was identified to suppress c-Maf activity in the presence of Otub1.	Polyketides	104-114	OTU domain, ubiquitin aldehyde binding 1	Mus musculus	46-51
32567115-1	2020	Chlorocyclopropanes (CCPs) conjugated to alk-yn-enes occur in a unique family of polyketide natural products from marine sponges.	Polyketides	81-91	ALK receptor tyrosine kinase	Homo sapiens	41-44
31134799-1	2019	The scaffolds of polyketides are constructed via assembly of extender units based on malonyl-CoA and its derivatives that are substituted at the C2-position with diverse chemical functionality.	Polyketides	17-28	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	93-96
31134799-3	2019	Yet, a biosensor for the detection of malonyl-CoA derivatives has yet to be reported, severely restricting the application of high-throughput synthetic biology approaches to engineering extender unit biosynthesis and limiting the ability to dynamically regulate the biosynthesis of polyketide products that are dependent on such alpha-carboxyacyl-CoAs.	Polyketides	282-292	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	46-49
31134799-6	2019	This FapR promiscuity proved sufficient for the detection of the polyketide extender unit methylmalonyl-CoA in E. coli, providing the first reported genetically encoded biosensor for this important metabolite.	Polyketides	65-75	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	104-107
29740674-5	2018	Deacetylmycoepoxydiene (DA-MED), a cytotoxic natural polyketide, functions as a Rac1 agonist in p53-null NSCLC H1299 cells.	Polyketides	53-63	tumor protein p53	Homo sapiens	96-99
29535686-0	2018	Diversity of Gene Clusters for Polyketide and Nonribosomal Peptide Biosynthesis Revealed by Metagenomic Analysis of the Yellow Sea Sediment.	Polyketides	31-41	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
28960976-0	2017	Stereochemical Characterization of Polyketide Stereotriads Synthesized via Hydrogen-Mediated Asymmetric syn-Crotylation.	Polyketides	35-45	synemin	Homo sapiens	104-107
28960976-1	2017	The stereoselective access to stereotriads as important polyketide building blocks is reported on the basis of the Krische-type hydrogen-mediated syn-crotylation.	Polyketides	56-66	synemin	Homo sapiens	146-149
28960976-4	2017	This extension of the burgeoning transfer hydrogen methodology gives divergent asymmetric access to anti,syn and syn,syn polyketide stereotriads from the same alpha-chiral starting material and avoids potentially epimerizable aldehyde intermediates.	Polyketides	121-131	synemin	Homo sapiens	113-116
28960976-4	2017	This extension of the burgeoning transfer hydrogen methodology gives divergent asymmetric access to anti,syn and syn,syn polyketide stereotriads from the same alpha-chiral starting material and avoids potentially epimerizable aldehyde intermediates.	Polyketides	121-131	synemin	Homo sapiens	113-116
27653519-1	2016	In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elongation, cyclization and product release.	Polyketides	23-33	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	79-82
27653519-4	2016	To further our understanding about how the ACP interacts with the product template (PT) domain that catalyzes polyketide cyclization, we developed the first mechanism-based crosslinkers for NR-PKSs.	Polyketides	110-120	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	43-46
27452503-3	2016	We here use modified biosynthesis for the generation of such a library of reduced polyketides to interfere with the oncogenic KRas pathway.	Polyketides	82-93	KRAS proto-oncogene, GTPase	Homo sapiens	126-130
27452503-5	2016	Structural and biophysical analyses revealed the nature of the interaction between the polyketides and KRas-interacting protein PDE6delta.	Polyketides	87-98	KRAS proto-oncogene, GTPase	Homo sapiens	103-107
28936328-2	2016	Biosynthesis is performed by polyketide synthases (PKSs), and the acyl carrier protein (ACP), a small acidic protein, that transports the growing polyketide chain and is essential for activity.	Polyketides	29-39	CPAT1	Homo sapiens	66-92
27399665-5	2016	This review summarizes the research findings on marine natural products and derivatives, mainly alkaloids, polyoxygenated sterols, polyketides, terpenoids, diketopiperazines, and peptides, with P-gp inhibitory activity highlighting the established structure-activity relationships.	Polyketides	131-142	ATP binding cassette subfamily B member 1	Homo sapiens	194-198
26976746-0	2016	Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.	Polyketides	14-24	synemin	Homo sapiens	54-57
26976746-3	2016	We demonstrate that by retaining a dimerization element present in LipPks1+TE, we are able to use a ketoreductase domain exchange to alter alpha-methyl group stereochemistry with unprecedented retention of activity and simultaneously achieve a novel alteration of polyketide product stereochemistry from anti to syn.	Polyketides	264-274	synemin	Homo sapiens	312-315
28936328-4	2016	These experiments were aimed at probing the ACP"s capacity to sequester a non-polar versus a phenolic aromatic ring (that more closely mimics a polyketide intermediate) as well as investigations with extended polyketide chain surrogates.	Polyketides	144-154	CPAT1	Homo sapiens	44-47
26714018-4	2015	Screening of compound libraries predicts targeting of NLRX1 by conjugated trienes, polyketides, prenol lipids, sterol lipids, and coenzyme A-containing fatty acids for activating the NLRX1 pathway.	Polyketides	83-94	NLR family member X1	Homo sapiens	54-59
26565618-3	2016	By screening a microbial extract library in a high content cell-based assay we detected the rare oligomycin class of Streptomyces polyketides as inhibitors of K-Ras PM localisation.	Polyketides	130-141	KRAS proto-oncogene, GTPase	Homo sapiens	159-164
26714018-4	2015	Screening of compound libraries predicts targeting of NLRX1 by conjugated trienes, polyketides, prenol lipids, sterol lipids, and coenzyme A-containing fatty acids for activating the NLRX1 pathway.	Polyketides	83-94	NLR family member X1	Homo sapiens	183-188
26631750-10	2015	This work completes the structural and functional characterization of mono- and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for engineered biosynthesis of new bioactive polyketides.	Polyketides	210-221	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	90-93
26631750-10	2015	This work completes the structural and functional characterization of mono- and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for engineered biosynthesis of new bioactive polyketides.	Polyketides	210-221	cytochrome c, somatic	Homo sapiens	94-98
25196242-3	2014	Further exploration with Sn(OTf)2 realized the rearrangement of a cross-aldehyde which tactically warrants the utility of the current approach to access complex polyketides.	Polyketides	161-172	POU class 2 homeobox 2	Homo sapiens	28-33
26631750-3	2015	The aromatase/cyclases (ARO/CYCs) are responsible for regiospecific cyclization of bacterial polyketides.	Polyketides	93-104	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	24-27
26631750-3	2015	The aromatase/cyclases (ARO/CYCs) are responsible for regiospecific cyclization of bacterial polyketides.	Polyketides	93-104	cytochrome c, somatic	Homo sapiens	28-32
26168137-1	2015	The Sfp-type 4"-phosphopantetheinyl transferase Ppt1 is required for activation of nonribosomal peptide synthetases, including alpha-aminoadipate reductase (AAR) for lysine biosynthesis and polyketide synthases, enzymes that biosynthesize peptide and polyketide secondary metabolites, respectively.	Polyketides	190-200	plastid phosphate/phosphoenolpyruvate translocator 1	Zea mays	48-52
25824639-1	2015	The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS).	Polyketides	4-14	threonyl-tRNA synthetase 1	Homo sapiens	179-203
25824639-1	2015	The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS).	Polyketides	4-14	threonyl-tRNA synthetase 1	Homo sapiens	205-210
26605048-5	2015	Subsequent experiments demonstrate that the products of medaka PKS, most likely polyketides or their derivatives, act as nucleation facilitators in otolith mineralization.	Polyketides	80-91	polyketide synthase 1	Oryzias latipes	63-66
26136222-2	2015	These polyketides were shown to possess antimicrobial effects and inhibitory activity towards the protease human leucocyte elastase (HLE).	Polyketides	6-17	elastase, neutrophil expressed	Homo sapiens	133-136
26048582-3	2015	Stilbene synthase-like (STS) enzymes are unique in the type III PKS class as they possess a hydrogen bonding network, furnishing them with thioesterase-like properties, resulting in aldol condensation of the polyketide intermediates formed.	Polyketides	208-218	stilbene synthase 3	Vitis vinifera	0-22
25415974-0	2014	ABCG26-mediated polyketide trafficking and hydroxycinnamoyl spermidines contribute to pollen wall exine formation in Arabidopsis.	Polyketides	16-26	ABC-2 type transporter family protein	Arabidopsis thaliana	0-6
25415974-9	2014	We propose a model where ABCG26-exported polyketides traffic from tapetal cells to form the sporopollenin backbone, in coordination with the trafficking of additional constituents, prior to tapetum programmed cell death.	Polyketides	41-52	ABC-2 type transporter family protein	Arabidopsis thaliana	25-31
24568283-4	2014	Here, we report the identification and characterization of three oxygenases from the fumagillin biosynthetic pathway, including a multifunctional cytochrome P450 monooxygenase, a hydroxylating nonheme-iron-dependent dioxygenase, and an ABM family monooxygenase for oxidative cleavage of the polyketide moiety.	Polyketides	291-301	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	146-175
25078432-2	2014	The synthesis of the malonyl-CoA building block, catalyzed by acetyl-CoA carboxylase (Acc1), is considered a limiting step to achieving high titers of polyketides and fatty acids in Saccharomyces cerevisiae.	Polyketides	151-162	acetyl-CoA carboxylase ACC1	Saccharomyces cerevisiae S288C	86-90
24597618-1	2014	The phytotoxic fungal polyketides lasiodiplodin and resorcylide inhibit human blood coagulation factor XIIIa, mineralocorticoid receptors, and prostaglandin biosynthesis.	Polyketides	22-33	coagulation factor XIII A chain	Homo sapiens	84-108
24875924-1	2014	polyketides as modulators of K-Ras localisation.	Polyketides	0-11	KRAS proto-oncogene, GTPase	Canis lupus familiaris	29-34
23978092-0	2013	Complexity generation in fungal polyketide biosynthesis: a spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin.	Polyketides	32-42	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	78-82
24660171-4	2014	Polyketide production was restored upon complementation with an intact copy of the scoT gene.	Polyketides	0-10	3-oxoacid CoA-transferase 1	Homo sapiens	83-87
22799266-4	2012	This finding supports a model according to which the ACP-bound polyketide intermediate is transferred back to the KS domain on the opposite PKS strand.	Polyketides	63-73	CPAT1	Homo sapiens	53-56
23820629-0	2013	Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.	Polyketides	11-22	nuclear receptor subfamily 1 group I member 2	Homo sapiens	76-79
23055407-0	2012	Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species.	Polyketides	72-82	cripto, FRL-1, cryptic family 1	Homo sapiens	64-71
22796259-0	2012	Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-kappaB pathways.	Polyketides	25-35	tumor protein p53	Homo sapiens	90-93
23499795-2	2013	Dalesconols B, also termed as TL2, is a newly found polyketide from a mantis-associated fungus and has been reported to exert potent immunosuppressive effects.	Polyketides	52-62	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	30-33
23550886-1	2013	Pantetheine and its corresponding disulfide pantethine play a key role in metabolism as building blocks of coenzyme A (CoA), an essential cofactor utilized in ~4% of primary metabolism and central to fatty acid, polyketide, and nonribosomal peptide synthases.	Polyketides	212-222	outer membrane porin F	Escherichia coli str. K-12 substr. MG1655	107-117
23550886-1	2013	Pantetheine and its corresponding disulfide pantethine play a key role in metabolism as building blocks of coenzyme A (CoA), an essential cofactor utilized in ~4% of primary metabolism and central to fatty acid, polyketide, and nonribosomal peptide synthases.	Polyketides	212-222	outer membrane porin F	Escherichia coli str. K-12 substr. MG1655	119-122
23297231-1	2013	The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1).	Polyketides	4-14	exportin 1	Homo sapiens	104-136
23297231-1	2013	The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1).	Polyketides	4-14	exportin 1	Homo sapiens	138-142
22934537-3	2012	Biochemical characterization of a library of 13 oxygenated polyketides isolated from the marine sponge Plakinastrella mamillaris allowed the discovery of gracilioether B and plakilactone C as selective PPARgamma ligands in transactivation assays.	Polyketides	59-70	peroxisome proliferator activated receptor gamma	Homo sapiens	202-211
22616796-3	2012	Aetheramides which contain a unique polyketide moiety and two amino acid residues potently inhibited HIV-1 infection with IC(50) values of ~0.015 muM.	Polyketides	36-46	latexin	Homo sapiens	146-149
22361940-3	2012	In addition, we provide an in vitro acyltransferase activity analysis that establishes proof of principle for the competency of PapA5 to utilize diol-containing polyketide compounds of mycobacterial origin as acyl-acceptor substrates.	Polyketides	161-171	PAPA5	Homo sapiens	128-133
22822354-4	2012	Antifungal, cytotoxic, and PTP1B inhibitory activities of these polyketides were evaluated.	Polyketides	64-75	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	27-32
22361940-4	2012	Overall, the results reported herein are in line with a model in which PapA5 catalyses the acylation of diol-containing polyketides to form PGLs.	Polyketides	120-131	PAPA5	Homo sapiens	71-76
22229794-4	2012	Covalent tethering of the 2-methyl-3-ketobutyryl thioester substrate to the NANS ACP1 domain derived from the natural upstream PKS module of the nanchangmycin synthase significantly enhanced both the stereospecificity and the kinetic efficiency of the sequential polyketide chain translocation and condensation reactions catalyzed by the ketosynthase domain of NANS module 2.	Polyketides	263-273	N-acetylneuraminate synthase	Homo sapiens	76-80
22432862-3	2012	Especially important in aromatic polyketide biosynthesis is the regiospecific cyclization of a linear, preassembled polyketide chain catalyzed by aromatase/cyclase (ARO/CYC), which serves as a key control point in aromatic ring formation.	Polyketides	33-43	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	165-168
22432862-3	2012	Especially important in aromatic polyketide biosynthesis is the regiospecific cyclization of a linear, preassembled polyketide chain catalyzed by aromatase/cyclase (ARO/CYC), which serves as a key control point in aromatic ring formation.	Polyketides	33-43	cytochrome c, somatic	Homo sapiens	169-172
22432862-3	2012	Especially important in aromatic polyketide biosynthesis is the regiospecific cyclization of a linear, preassembled polyketide chain catalyzed by aromatase/cyclase (ARO/CYC), which serves as a key control point in aromatic ring formation.	Polyketides	116-126	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	165-168
22432862-3	2012	Especially important in aromatic polyketide biosynthesis is the regiospecific cyclization of a linear, preassembled polyketide chain catalyzed by aromatase/cyclase (ARO/CYC), which serves as a key control point in aromatic ring formation.	Polyketides	116-126	cytochrome c, somatic	Homo sapiens	169-172
22229794-4	2012	Covalent tethering of the 2-methyl-3-ketobutyryl thioester substrate to the NANS ACP1 domain derived from the natural upstream PKS module of the nanchangmycin synthase significantly enhanced both the stereospecificity and the kinetic efficiency of the sequential polyketide chain translocation and condensation reactions catalyzed by the ketosynthase domain of NANS module 2.	Polyketides	263-273	acid phosphatase 1	Homo sapiens	81-85
22229794-4	2012	Covalent tethering of the 2-methyl-3-ketobutyryl thioester substrate to the NANS ACP1 domain derived from the natural upstream PKS module of the nanchangmycin synthase significantly enhanced both the stereospecificity and the kinetic efficiency of the sequential polyketide chain translocation and condensation reactions catalyzed by the ketosynthase domain of NANS module 2.	Polyketides	263-273	N-acetylneuraminate synthase	Homo sapiens	145-167
22229794-4	2012	Covalent tethering of the 2-methyl-3-ketobutyryl thioester substrate to the NANS ACP1 domain derived from the natural upstream PKS module of the nanchangmycin synthase significantly enhanced both the stereospecificity and the kinetic efficiency of the sequential polyketide chain translocation and condensation reactions catalyzed by the ketosynthase domain of NANS module 2.	Polyketides	263-273	N-acetylneuraminate synthase	Homo sapiens	361-365
20136099-1	2010	Acyl (peptidyl) carrier protein (ACP or PCP) is a crucial component involved in the transfer of thiol ester-bound intermediates during the biosynthesis of primary and secondary metabolites such as fatty acids, polyketides, and nonribosomal peptides.	Polyketides	210-221	CPAT1	Homo sapiens	33-36
21870821-3	2011	The aromatase/cyclases (ARO/CYCs) are an important component of the type II polyketide synthase (PKS) and help fold the polyketide for regiospecific cyclizations of the first ring and/or aromatization, promoting two commonly observed first-ring cyclization patterns for the bacterial type II PKSs: C7-C12 and C9-C14.	Polyketides	76-86	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	24-27
21870821-3	2011	The aromatase/cyclases (ARO/CYCs) are an important component of the type II polyketide synthase (PKS) and help fold the polyketide for regiospecific cyclizations of the first ring and/or aromatization, promoting two commonly observed first-ring cyclization patterns for the bacterial type II PKSs: C7-C12 and C9-C14.	Polyketides	76-86	cytochrome c, somatic	Homo sapiens	28-32
21870821-6	2011	In this work, we present the 2.4 A crystal structure of ZhuI, a C7-C12-specific first-ring ARO/CYC from the type II PKS pathway responsible for the production of the R1128 polyketides.	Polyketides	172-183	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	91-94
21870821-6	2011	In this work, we present the 2.4 A crystal structure of ZhuI, a C7-C12-specific first-ring ARO/CYC from the type II PKS pathway responsible for the production of the R1128 polyketides.	Polyketides	172-183	cytochrome c, somatic	Homo sapiens	95-98
21138727-3	2011	To demonstrate, we characterized the binding of polyketide ligands based on the mTOR inhibitor rapamycin to the cellular immunophilin FKBP12.	Polyketides	48-58	mechanistic target of rapamycin kinase	Homo sapiens	80-84
21138727-3	2011	To demonstrate, we characterized the binding of polyketide ligands based on the mTOR inhibitor rapamycin to the cellular immunophilin FKBP12.	Polyketides	48-58	FKBP prolyl isomerase 1A	Homo sapiens	121-140
21627316-3	2011	Whereas reactions conducted using conventional heating require 48 h, microwave irradiation enables full conversion in only 4 h. Finally, as illustrated in the conversion of adduct 4a to compounds 6a and 6b, diastereoselective hydroboration-Suzuki cross-coupling with aryl and vinyl halides followed by Fleming-Tamao oxidation enables generation of anti,syn-stereotriads found in numerous polyketide natural products.	Polyketides	388-398	synemin	Homo sapiens	353-356
19492384-1	2009	Discriminating elimination: A new method for the synthesis of methyl-branched trisubstituted Z olefins, a structural motif in many polyketides with anticancer activity, relies on an (-)OH-induced decarboxylative Grob-type fragmentation (see scheme; Ms = mesyl).	Polyketides	131-142	C-X-C motif chemokine ligand 2	Homo sapiens	212-216
19405532-4	2009	Here we report the characterization of LnmK from the leinamycin biosynthetic machinery as a bifunctional acyltransferase/decarboxylase (AT/DC) that derives propionyl-S-ACP from methylmalonyl-CoA, accounting for the missing link of the beta-ethyl or propionyl branch in polyketide biosynthesis.	Polyketides	269-279	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	168-171
18666307-5	2008	Herein we report a method that provides insight into both substrate specificity and compatibility of protein-protein interactions between the acyl carrier protein (ACP) and ketosynthase (KS) domains involved in fatty acid and polyketide biosynthesis.	Polyketides	226-236	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	142-162
18666307-5	2008	Herein we report a method that provides insight into both substrate specificity and compatibility of protein-protein interactions between the acyl carrier protein (ACP) and ketosynthase (KS) domains involved in fatty acid and polyketide biosynthesis.	Polyketides	226-236	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	164-167