PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33340663-1	2021	In an in-house screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK.	pyrrolo(2, 3-b)pyridine	26-51	TRAF2 and NCK interacting kinase	Homo sapiens	98-102
33340663-0	2021	Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors.	pyrrolo(2, 3-b)pyridine	25-50	TRAF2 and NCK interacting kinase	Homo sapiens	71-75
2945856-5	1986	The GVH-induced hematopoietic defect required parental T cell recognition of both class I and class II H-2 alloantigens expressed by the F1 host.	pyrrolo(2, 3-b)pyridine	4-7	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	82-106
33744686-3	2021	Sulfonylurea derivatives have been reported as antidiabetic and anticancer agents, therefore, we synthesized and investigated series of sulfonylurea derivatives 1a-m possessing pyrrolo[2,3-b]pyridine core as inhibitors of NPP1 and NPP3 isozymes that are over-expressed in cancer and diabetes.	pyrrolo(2, 3-b)pyridine	177-199	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	222-226
33744686-3	2021	Sulfonylurea derivatives have been reported as antidiabetic and anticancer agents, therefore, we synthesized and investigated series of sulfonylurea derivatives 1a-m possessing pyrrolo[2,3-b]pyridine core as inhibitors of NPP1 and NPP3 isozymes that are over-expressed in cancer and diabetes.	pyrrolo(2, 3-b)pyridine	177-199	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	231-235
32340792-1	2020	Several pyrrolo[2,3-b]pyridine-based B-RAF inhibitors are well known and some of them are currently FDA approved as anticancer agents.	pyrrolo(2, 3-b)pyridine	8-30	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	37-42
32340792-2	2020	Based on the structure of these FDA approved V600EB-RAF inhibitors, two series of pyrrolo[2,3-b]pyridine scaffold were designed and synthesized in attempt to develop new potent V600EB-RAF inhibitors.	pyrrolo(2, 3-b)pyridine	82-104	zinc fingers and homeoboxes 2	Homo sapiens	52-55
32340792-2	2020	Based on the structure of these FDA approved V600EB-RAF inhibitors, two series of pyrrolo[2,3-b]pyridine scaffold were designed and synthesized in attempt to develop new potent V600EB-RAF inhibitors.	pyrrolo(2, 3-b)pyridine	82-104	zinc fingers and homeoboxes 2	Homo sapiens	184-187
26923692-0	2016	Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 1,2,3-triazole moiety as c-Met kinase inhibitors.	pyrrolo(2, 3-b)pyridine	19-41	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	87-92
31002441-4	2019	We present here a new series of pyrrolo[2,3-b]pyridine derivatives of our previously reported potent HNE inhibitors.	pyrrolo(2, 3-b)pyridine	32-54	elastase, neutrophil expressed	Homo sapiens	101-104
31002441-5	2019	Our results show that position 2 of the pyrrolo[2,3-b]pyridine scaffold must be unsubstituted, and modifications of this position resulted in loss of HNE inhibitory activity.	pyrrolo(2, 3-b)pyridine	40-62	elastase, neutrophil expressed	Homo sapiens	150-153
30385225-0	2018	1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors.	pyrrolo(2, 3-b)pyridine	0-25	elastase, neutrophil expressed	Homo sapiens	52-71
30385225-0	2018	1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors.	pyrrolo(2, 3-b)pyridine	0-25	elastase, neutrophil expressed	Homo sapiens	73-76
30385225-3	2018	Here, we report the synthesis and biological evaluation of a new series of HNE inhibitors with a pyrrolo[2,3-b]pyridine scaffold, which is an isomer of our previously reported indazoles, in order to assess how a shift of the nitrogen from position 2 to position 7 influences activity.	pyrrolo(2, 3-b)pyridine	97-119	elastase, neutrophil expressed	Homo sapiens	75-78
30385225-7	2018	Docking experiments showed that orientation of the active pyrrolo[2,3-b]pyridines in the HNE catalytic triad Ser195-His57-Asp102 correlated with effectiveness of the inhibitor interaction with the enzyme.	pyrrolo(2, 3-b)pyridine	58-81	elastase, neutrophil expressed	Homo sapiens	89-92
30385225-8	2018	Thus, the pyrrolo[2,3-b]pyridine scaffold represents a novel scaffold for the development of potent HNE inhibitors.	pyrrolo(2, 3-b)pyridine	10-32	elastase, neutrophil expressed	Homo sapiens	100-103
28279528-0	2017	Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.	pyrrolo(2, 3-b)pyridine	28-53	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	100-103
28279528-1	2017	In a pursuit to identify reversible and selective BTK inhibitors, two series based on 7H-pyrrolo[2,3-d]pyrimidine and 1H-pyrrolo[2,3-b]pyridine as the hinge binding core, have been identified.	pyrrolo(2, 3-b)pyridine	118-143	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	50-53
26964675-0	2016	Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.	pyrrolo(2, 3-b)pyridine	83-108	steroid sulfatase	Homo sapiens	116-120
32155989-3	2020	In this study, we discovered a novel 1H-pyrrolo[2,3-b]pyridine derivative B10 as a GSK-3beta inhibitor that features with a quinolin-8-ol moiety to target the metal dyshomeostasis of AD.	pyrrolo(2, 3-b)pyridine	37-62	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	74-77
32155989-3	2020	In this study, we discovered a novel 1H-pyrrolo[2,3-b]pyridine derivative B10 as a GSK-3beta inhibitor that features with a quinolin-8-ol moiety to target the metal dyshomeostasis of AD.	pyrrolo(2, 3-b)pyridine	37-62	glycogen synthase kinase 3 alpha	Homo sapiens	83-92
31658862-0	2019	Prediction of cytotoxic activity of a series of 1H-pyrrolo[2,3-b]pyridine derivatives as possible inhibitors of c-Met using molecular fingerprints.	pyrrolo(2, 3-b)pyridine	48-73	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	112-117
31136173-4	2019	Because AAK1 is a promising antiviral drug target, we have embarked on an optimization campaign of a previously identified 7-azaindole analogue, yielding novel pyrrolo[2,3- b]pyridines with high AAK1 affinity.	pyrrolo(2, 3-b)pyridine	160-184	AP2 associated kinase 1	Homo sapiens	8-12
31136173-4	2019	Because AAK1 is a promising antiviral drug target, we have embarked on an optimization campaign of a previously identified 7-azaindole analogue, yielding novel pyrrolo[2,3- b]pyridines with high AAK1 affinity.	pyrrolo(2, 3-b)pyridine	160-184	AP2 associated kinase 1	Homo sapiens	195-199
29331754-0	2018	Synthesis and bioevaluation and doking study of 1H-pyrrolo[2,3-b]pyridine derivatives bearing aromatic hydrazone moiety as c-Met inhibitors.	pyrrolo(2, 3-b)pyridine	48-73	steroid sulfatase	Homo sapiens	120-124
26950400-0	2016	Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors.	pyrrolo(2, 3-b)pyridine	47-72	steroid sulfatase	Homo sapiens	116-120
26950400-1	2016	Five novel 1H-pyrrolo[2,3-b]pyridine or 1H-pyrazolo[3,4-b]pyridine derivatives, with a methylene, sulfur, sulfoxide or cyclopropyl group as a linker, were designed, synthesized and biologically evaluated against c-Met and ALK.	pyrrolo(2, 3-b)pyridine	11-36	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	212-217
26950400-1	2016	Five novel 1H-pyrrolo[2,3-b]pyridine or 1H-pyrazolo[3,4-b]pyridine derivatives, with a methylene, sulfur, sulfoxide or cyclopropyl group as a linker, were designed, synthesized and biologically evaluated against c-Met and ALK.	pyrrolo(2, 3-b)pyridine	11-36	ALK receptor tyrosine kinase	Homo sapiens	222-225
26923692-1	2016	A series of novel pyrrolo[2,3-b]pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities and antiproliferative activities against 4 cancer cell lines (HT-29, A549, MCF-7, and PC-3) in vitro.	pyrrolo(2, 3-b)pyridine	18-40	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	135-140
26810712-0	2016	Design, synthesis, and docking studies of phenylpicolinamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.	pyrrolo(2, 3-b)pyridine	81-106	steroid sulfatase	Homo sapiens	114-118
26059596-2	2015	To identify JAK inhibitors, we focused on the 1H-pyrrolo[2,3-b]pyridine derivative 3, which exhibited moderate JAK3 and JAK1 inhibitory activities.	pyrrolo(2, 3-b)pyridine	46-71	Janus kinase 3	Homo sapiens	111-115
26741853-1	2016	From four molecules, inspired by the structural features of fascaplysin, with an interesting potential to inhibit cyclin-dependent kinases (CDKs), we designed a new series of tri-heterocyclic derivatives based on 1H-pyrrolo[2,3-b]pyridine (7-azaindole) and triazole heterocycles.	pyrrolo(2, 3-b)pyridine	213-238	cyclin dependent kinase 2	Homo sapiens	140-144
26059596-2	2015	To identify JAK inhibitors, we focused on the 1H-pyrrolo[2,3-b]pyridine derivative 3, which exhibited moderate JAK3 and JAK1 inhibitory activities.	pyrrolo(2, 3-b)pyridine	46-71	Janus kinase 1	Homo sapiens	120-124
26169764-0	2015	Pyrrolo[2,3-b]pyridine derivatives as potent Bruton"s tyrosine kinase inhibitors.	pyrrolo(2, 3-b)pyridine	0-22	Bruton tyrosine kinase	Homo sapiens	45-69
26169764-1	2015	A series of pyrrolo[2,3-b]pyridine-based derivatives were designed as potent Bruton"s tyrosine kinase (BTK) inhibitors by using a scaffold-hopping strategy.	pyrrolo(2, 3-b)pyridine	12-34	Bruton tyrosine kinase	Homo sapiens	77-101
25786493-2	2015	Here, we describe a series of 1H-pyrrolo[2,3-b]pyridine derivatives as novel immunomodulators targeting JAK3 for use in treating immune diseases such as organ transplantation.	pyrrolo(2, 3-b)pyridine	30-55	Janus kinase 3	Homo sapiens	104-108
26169764-1	2015	A series of pyrrolo[2,3-b]pyridine-based derivatives were designed as potent Bruton"s tyrosine kinase (BTK) inhibitors by using a scaffold-hopping strategy.	pyrrolo(2, 3-b)pyridine	12-34	Bruton tyrosine kinase	Homo sapiens	103-106
25786493-3	2015	In the chemical modification of compound 6, the introduction of a carbamoyl group to the C5-position and substitution of a cyclohexylamino group at the C4-position of the 1H-pyrrolo[2,3-b]pyridine ring led to a large increase in JAK3 inhibitory activity.	pyrrolo(2, 3-b)pyridine	171-196	Janus kinase 3	Homo sapiens	229-233
25099343-0	2014	Discovery of a novel class of diacylglycerol acyltransferase 2 inhibitors with a 1H-pyrrolo[2,3-b]pyridine core.	pyrrolo(2, 3-b)pyridine	81-106	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	30-62
25099343-2	2014	Here, using an in vitro screen of 20000 molecules, we identified a class of compounds with a substituted 1H-pyrrolo[2,3-b]pyridine core which proved to be potent and selective inhibitors of human DGAT2.	pyrrolo(2, 3-b)pyridine	105-130	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	196-201
23294348-4	2013	The establishment of highly substituted unprecedented 1H-pyrrolo[2,3-b]pyridine derivatizations provided compounds with submicromolar cellular FAK inhibition potential.	pyrrolo(2, 3-b)pyridine	54-79	protein tyrosine kinase 2	Homo sapiens	143-146
24900635-1	2013	Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo[2,3-b]pyridines, and furo[2,3-d]pyrimidines, all of the type II class recognizing a DLG-out inactive conformation, were identified from screening of our in-house kinase focused sets.	pyrrolo(2, 3-b)pyridine	83-106	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	21-25
19555113-2	2009	In this paper, we describe synthesis and structure-activity relationships of new 1H-pyrrolo[2,3-b]pyridine derivatives identified as inhibitors of Cdc7 kinase.	pyrrolo(2, 3-b)pyridine	81-106	cell division cycle 7	Homo sapiens	147-151
15943483-1	2005	Two new classes of tricyclic-based corticotropin-releasing factor (CRF(1)) receptor-1 antagonists were designed by constraining known 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine ligands.	pyrrolo(2, 3-b)pyridine	134-159	corticotropin releasing hormone	Rattus norvegicus	35-65
8959843-4	1996	Severe tissue injury of GvH-susceptible target organs in the setting of simultaneous SB and BMTx was associated with significant changes in recruitment and tissue distribution of NKR-P1+ cells during the GvH-related proliferative immune response.	pyrrolo(2, 3-b)pyridine	24-27	killer cell lectin like receptor B1	Homo sapiens	179-185
15465327-0	2004	Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging.	pyrrolo(2, 3-b)pyridine	49-74	dopamine receptor D4	Mus musculus	91-111