PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33957677-5	2021	Quantitative real-time RT-PCR was applied to investigate the effect of WN or fluoxetine on the expression of serotonin receptors (ser-1, ser-4, ser-7) and serotonin transporter (mod-5).	withanone	71-73	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	130-135
33957677-9	2021	In silico analyses revealed high binding affinities of WN to Ser-1, Ser-4, Ser-7, and Mod-5.	withanone	55-57	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	61-66
33957677-9	2021	In silico analyses revealed high binding affinities of WN to Ser-1, Ser-4, Ser-7, and Mod-5.	withanone	55-57	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	68-73
33957677-9	2021	In silico analyses revealed high binding affinities of WN to Ser-1, Ser-4, Ser-7, and Mod-5.	withanone	55-57	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	75-80
33957677-9	2021	In silico analyses revealed high binding affinities of WN to Ser-1, Ser-4, Ser-7, and Mod-5.	withanone	55-57	Transporter	Caenorhabditis elegans	86-91
33957677-5	2021	Quantitative real-time RT-PCR was applied to investigate the effect of WN or fluoxetine on the expression of serotonin receptors (ser-1, ser-4, ser-7) and serotonin transporter (mod-5).	withanone	71-73	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	137-142
33957677-5	2021	Quantitative real-time RT-PCR was applied to investigate the effect of WN or fluoxetine on the expression of serotonin receptors (ser-1, ser-4, ser-7) and serotonin transporter (mod-5).	withanone	71-73	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	144-149
33957677-5	2021	Quantitative real-time RT-PCR was applied to investigate the effect of WN or fluoxetine on the expression of serotonin receptors (ser-1, ser-4, ser-7) and serotonin transporter (mod-5).	withanone	71-73	Transporter	Caenorhabditis elegans	178-183
33797339-5	2021	We found that among all withanolides, Withaferin-A, Withanone, Withanoside-IV and Withanoside-V significantly inhibited the ACE2 expression.	withanone	52-61	angiotensin converting enzyme 2	Homo sapiens	124-128
33460762-11	2021	The in vitro half-life of WN in RLM and HLM was found to be 59.63+-2.50 and 68.42+-2.19 min, respectively.	withanone	26-28	oxysterol binding protein 2	Homo sapiens	40-43
33460762-12	2021	CYP phenotyping results showed that WN was extensively metabolized by CYP 3A4 and1A2 enzymes in RLM and HLM.	withanone	36-38	peptidylprolyl isomerase G	Homo sapiens	0-3
33460762-12	2021	CYP phenotyping results showed that WN was extensively metabolized by CYP 3A4 and1A2 enzymes in RLM and HLM.	withanone	36-38	oxysterol binding protein 2	Homo sapiens	104-107
32469279-0	2022	Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells.	withanone	0-9	transmembrane serine protease 2	Homo sapiens	58-89
33737804-0	2021	Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model.	withanone	0-9	angiotensin converting enzyme 2	Homo sapiens	69-73
33737804-0	2021	Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model.	withanone	0-9	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	97-102
33737804-5	2021	Methods: Through molecular docking, molecular dynamic (MD) simulation and electrostatic energy calculation the plausible biochemical interactions between withanone and the ACE2-RBD complex were investigated.	withanone	154-163	angiotensin converting enzyme 2	Homo sapiens	172-176
33737804-7	2021	Withanone-enriched extract from W. somnifera was tested for its ability to ameliorate clinically relevant pathological features, modelled in humanized zebrafish through SARS-CoV-2 recombinant spike (S) protein induction.	withanone	0-9	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	192-197
33737804-7	2021	Withanone-enriched extract from W. somnifera was tested for its ability to ameliorate clinically relevant pathological features, modelled in humanized zebrafish through SARS-CoV-2 recombinant spike (S) protein induction.	withanone	0-9	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	169-170
33737804-8	2021	Results: Withanone bound efficiently at the interacting interface of the ACE2-RBD complex and destabilized it energetically.	withanone	9-18	angiotensin converting enzyme 2	Homo sapiens	73-77
33737804-10	2021	The two intrachain salt bridge interactions (K31-E35) and the interchain long-range ion-pair (K31-E484), at the ACE2-RBD interface were completely abolished by withanone, in the 50 ns simulation.	withanone	160-169	angiotensin converting enzyme 2	Homo sapiens	112-116
33737804-11	2021	In vitro binding assay experimentally validated that withanone efficiently inhibited (IC50=0.33 ng/mL) the interaction between ACE2 and RBD, in a dose-dependent manner.	withanone	53-62	angiotensin converting enzyme 2	Homo sapiens	127-131
32469279-0	2022	Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells.	withanone	0-9	transmembrane serine protease 2	Homo sapiens	91-98
30808373-5	2019	METHODS: We used bioinformatics and molecular docking tools to investigate the structural changes between the wild type and mutant p53 proteins (p53V143A, p53R249S, p53R273H and p53Y220C) and explored the therapeutic potential of Withaferin A and Withanone for restoration of wild type p53 function in cancer cells.	withanone	247-256	tumor protein p53	Homo sapiens	131-134
32431217-0	2021	Withanone and Caffeic Acid Phenethyl Ester are Predicted to Interact with Main Protease (Mpro) of SARS-CoV-2 and Inhibit its Activity.	withanone	0-9	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	89-93
33244909-11	2020	With respect to functionality, the basal Parker Scale median (EP) for the WN group was 9 (RIC6-9) and for MN was 5 (RIC3-9) p 0.001, 6 months (RIC3-6) and 4 (RIC2-6) p 0.001 and 12 months 6 (RIC4-7) and 3 (RIC2-6) p 0.001.	withanone	74-76	RIC8 guanine nucleotide exchange factor A	Homo sapiens	90-96
30808373-12	2019	Using human cell lines containing specific p53 mutant proteins, we demonstrated that Withaferin A, Withanone and the extract rich in these withanolides caused restoration of wild type p53 function in mutant p53Y220C cells.	withanone	99-108	tumor protein p53	Homo sapiens	43-46
30808373-12	2019	Using human cell lines containing specific p53 mutant proteins, we demonstrated that Withaferin A, Withanone and the extract rich in these withanolides caused restoration of wild type p53 function in mutant p53Y220C cells.	withanone	99-108	tumor protein p53	Homo sapiens	184-187
29108796-3	2018	Withanone (WS-2), a compound isolated from root extract of Withania somnifera at doses administered orally/day to wistar rats for duration of 21 days showed significant improvement in the cognitive skill by inhibiting amyloid beta-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1 beta, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both beta- and gamma- secretase enzymatic activity.	withanone	0-9	tumor necrosis factor	Rattus norvegicus	304-313
29108796-3	2018	Withanone (WS-2), a compound isolated from root extract of Withania somnifera at doses administered orally/day to wistar rats for duration of 21 days showed significant improvement in the cognitive skill by inhibiting amyloid beta-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1 beta, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both beta- and gamma- secretase enzymatic activity.	withanone	0-9	interleukin 1 alpha	Rattus norvegicus	315-324
29108796-3	2018	Withanone (WS-2), a compound isolated from root extract of Withania somnifera at doses administered orally/day to wistar rats for duration of 21 days showed significant improvement in the cognitive skill by inhibiting amyloid beta-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1 beta, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both beta- and gamma- secretase enzymatic activity.	withanone	0-9	interleukin 6	Rattus norvegicus	326-330
29108796-3	2018	Withanone (WS-2), a compound isolated from root extract of Withania somnifera at doses administered orally/day to wistar rats for duration of 21 days showed significant improvement in the cognitive skill by inhibiting amyloid beta-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1 beta, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both beta- and gamma- secretase enzymatic activity.	withanone	0-9	mast cell protease 1-like 1	Rattus norvegicus	332-337
22155302-0	2012	Withanone binds to mortalin and abrogates mortalin-p53 complex: computational and experimental evidence.	withanone	0-9	tumor protein p53	Homo sapiens	51-54
22155302-5	2012	We found that withanone could bind to mortalin in a region, earlier predicted critical for binding to p53.	withanone	14-23	tumor protein p53	Homo sapiens	102-105
22155302-8	2012	We also demonstrate the experimental evidence of abrogation of mortalin-p53 complex by withanone resulting in nuclear translocation and functional reactivation of p53 in human cancer cells.	withanone	87-96	tumor protein p53	Homo sapiens	72-75
22155302-8	2012	We also demonstrate the experimental evidence of abrogation of mortalin-p53 complex by withanone resulting in nuclear translocation and functional reactivation of p53 in human cancer cells.	withanone	87-96	tumor protein p53	Homo sapiens	163-166
21573189-6	2011	Withanone protects cells from MAA-induced toxicity by suppressing the ROS levels, DNA and mitochondrial damage, and induction of cell defense signaling pathways including Nrf2 and proteasomal degradation.	withanone	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	171-175