PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31891999-4	2020	The method was validated with a correlation coefficient above 0.99, and a limit of detection and quantification of 0.01 mug L-1 and 0.15 mug L-1 respectively, which were determined by a linear curve at low 4-NP concentrations.	4-nonylphenol	206-210	immunoglobulin kappa variable 1-16	Homo sapiens	124-136
33957011-7	2021	We found that 4-NP, in a range of concentration from 50 to 100 muM, significantly reduced cell viability; it caused a partial block of proliferation and induced apoptosis with activation of caspase-3 and overexpression of p53.	4-nonylphenol	14-18	caspase 3	Homo sapiens	190-199
33957011-7	2021	We found that 4-NP, in a range of concentration from 50 to 100 muM, significantly reduced cell viability; it caused a partial block of proliferation and induced apoptosis with activation of caspase-3 and overexpression of p53.	4-nonylphenol	14-18	tumor protein p53	Homo sapiens	222-225
33957011-8	2021	Moreover, 4-NP induced-apoptosis seemed to involve both an ER-stress response, with the appearance of high level of GRP78, CHOP and the spliced XBP1, and a dysregulation of mitochondrial physiology, characterized by an overexpression of main markers of mitochondrial dynamics.	4-nonylphenol	10-14	heat shock protein family A (Hsp70) member 5	Homo sapiens	116-121
33957011-8	2021	Moreover, 4-NP induced-apoptosis seemed to involve both an ER-stress response, with the appearance of high level of GRP78, CHOP and the spliced XBP1, and a dysregulation of mitochondrial physiology, characterized by an overexpression of main markers of mitochondrial dynamics.	4-nonylphenol	10-14	DNA damage inducible transcript 3	Homo sapiens	123-127
33957011-8	2021	Moreover, 4-NP induced-apoptosis seemed to involve both an ER-stress response, with the appearance of high level of GRP78, CHOP and the spliced XBP1, and a dysregulation of mitochondrial physiology, characterized by an overexpression of main markers of mitochondrial dynamics.	4-nonylphenol	10-14	X-box binding protein 1	Homo sapiens	144-148
33026593-10	2021	Catalase activity in liver was significantly lower in 4-NP group only.	4-nonylphenol	54-58	catalase	Rattus norvegicus	0-8
31318310-7	2021	The pseudo-first-order rate constant was estimated as 1.648 x 10 -2 min-1 for the reduction of 4-NP using g-C3N4/Bi2S3 composite in 1 h reaction time.	4-nonylphenol	95-99	CD59 molecule (CD59 blood group)	Homo sapiens	68-73
32360618-0	2020	Molecular interactions of thyroxine binding globulin and thyroid hormone receptor with estrogenic compounds 4-nonylphenol, 4-tert-octylphenol and bisphenol A metabolite (MBP).	4-nonylphenol	108-121	serpin family A member 7	Homo sapiens	26-52
31891999-4	2020	The method was validated with a correlation coefficient above 0.99, and a limit of detection and quantification of 0.01 mug L-1 and 0.15 mug L-1 respectively, which were determined by a linear curve at low 4-NP concentrations.	4-nonylphenol	206-210	immunoglobulin kappa variable 1-16	Homo sapiens	124-127
31891999-6	2020	Eighty-three percent of samples had detectable concentrations of 4-NP with a maximum concentration of 12.61 mug L-1, 12.2 mug L-1 and 6.08 mug L-1 in recreational water, wastewater discharges and drinking water respectively.	4-nonylphenol	65-69	immunoglobulin kappa variable 1-16	Homo sapiens	112-115
31891999-6	2020	Eighty-three percent of samples had detectable concentrations of 4-NP with a maximum concentration of 12.61 mug L-1, 12.2 mug L-1 and 6.08 mug L-1 in recreational water, wastewater discharges and drinking water respectively.	4-nonylphenol	65-69	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
31891999-6	2020	Eighty-three percent of samples had detectable concentrations of 4-NP with a maximum concentration of 12.61 mug L-1, 12.2 mug L-1 and 6.08 mug L-1 in recreational water, wastewater discharges and drinking water respectively.	4-nonylphenol	65-69	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
31767456-0	2020	The steroid receptor coactivator 1 (SRC1) and 3 (SRC3) recruitment as a novel molecular initiating event of 4-n-nonylphenol in estrogen receptor alpha-mediated pathways.	4-nonylphenol	108-123	estrogen receptor 1	Homo sapiens	127-150
31767456-4	2020	In MCF7 cell proliferation (E-SCREEN) assay and MVLN cell assay, 4-n-NP showed significant estrogenic potency that involved an increase in estrogen receptor alpha (ERalpha), SRC1 and SRC3 transcript levels.	4-nonylphenol	65-71	estrogen receptor 1	Homo sapiens	139-162
31767456-0	2020	The steroid receptor coactivator 1 (SRC1) and 3 (SRC3) recruitment as a novel molecular initiating event of 4-n-nonylphenol in estrogen receptor alpha-mediated pathways.	4-nonylphenol	108-123	nuclear receptor coactivator 1	Homo sapiens	4-34
31767456-0	2020	The steroid receptor coactivator 1 (SRC1) and 3 (SRC3) recruitment as a novel molecular initiating event of 4-n-nonylphenol in estrogen receptor alpha-mediated pathways.	4-nonylphenol	108-123	nuclear receptor coactivator 1	Homo sapiens	36-40
31767456-0	2020	The steroid receptor coactivator 1 (SRC1) and 3 (SRC3) recruitment as a novel molecular initiating event of 4-n-nonylphenol in estrogen receptor alpha-mediated pathways.	4-nonylphenol	108-123	nuclear receptor coactivator 3	Homo sapiens	49-53
31767456-4	2020	In MCF7 cell proliferation (E-SCREEN) assay and MVLN cell assay, 4-n-NP showed significant estrogenic potency that involved an increase in estrogen receptor alpha (ERalpha), SRC1 and SRC3 transcript levels.	4-nonylphenol	65-71	estrogen receptor 1	Homo sapiens	164-171
31767456-4	2020	In MCF7 cell proliferation (E-SCREEN) assay and MVLN cell assay, 4-n-NP showed significant estrogenic potency that involved an increase in estrogen receptor alpha (ERalpha), SRC1 and SRC3 transcript levels.	4-nonylphenol	65-71	nuclear receptor coactivator 1	Homo sapiens	174-178
31767456-4	2020	In MCF7 cell proliferation (E-SCREEN) assay and MVLN cell assay, 4-n-NP showed significant estrogenic potency that involved an increase in estrogen receptor alpha (ERalpha), SRC1 and SRC3 transcript levels.	4-nonylphenol	65-71	nuclear receptor coactivator 3	Homo sapiens	183-187
31767456-5	2020	Moreover, 4-n-NP was found to induce estrogen response element (ERE)-mediated activity via ERalpha in MVLN cells.	4-nonylphenol	10-16	estrogen receptor 1	Homo sapiens	91-98
31767456-8	2020	This is the first report to investigate the novel MIE of SRCs recruitment in 4-n-NP-ERalpha-induced estrogenicity.	4-nonylphenol	77-83	estrogen receptor 1	Homo sapiens	84-91
31767456-9	2020	Overall, our results suggest that the action of 4-n-NP on estrogenic effects involves the following MIEs: the activation of ERalpha, the recruitment of SRC1 and SRC3, and the induction of ERE-mediated activity.	4-nonylphenol	48-54	estrogen receptor 1	Homo sapiens	124-131
31767456-9	2020	Overall, our results suggest that the action of 4-n-NP on estrogenic effects involves the following MIEs: the activation of ERalpha, the recruitment of SRC1 and SRC3, and the induction of ERE-mediated activity.	4-nonylphenol	48-54	nuclear receptor coactivator 1	Homo sapiens	152-156
31767456-9	2020	Overall, our results suggest that the action of 4-n-NP on estrogenic effects involves the following MIEs: the activation of ERalpha, the recruitment of SRC1 and SRC3, and the induction of ERE-mediated activity.	4-nonylphenol	48-54	nuclear receptor coactivator 3	Homo sapiens	161-165
32368982-0	2020	p-Nonylphenol Impairment of Osteogenic Differentiation of Mesenchymal Stem Cells was found to be due to Oxidative Stress and Down Regulation of RUNX2 and BMP.	4-nonylphenol	0-13	RUNX family transcription factor 2	Rattus norvegicus	144-149
32368982-10	2020	Investigating the genes involved in the osteogenic differentiation of MSCs to osteoblast showed that the 2.5 microM of p-NP reduced the expression of the ALP, SMAD, BMP and RUNX2 genes.	4-nonylphenol	119-123	PDZ and LIM domain 3	Rattus norvegicus	154-157
32368982-10	2020	Investigating the genes involved in the osteogenic differentiation of MSCs to osteoblast showed that the 2.5 microM of p-NP reduced the expression of the ALP, SMAD, BMP and RUNX2 genes.	4-nonylphenol	119-123	RUNX family transcription factor 2	Rattus norvegicus	173-178
30954815-2	2019	Thus, this study aimed to understand the role of subsoil SOC in sorption processes of 4-n-nonylphenol (NP) and perfluorooctanoic acid (PFOA) as model pollutants.	4-nonylphenol	103-105	UBX domain protein 11	Homo sapiens	57-60
31310970-0	2019	Protective effect of p53 knockout on 4-nonylphenol-induced nephrotoxicity in medaka (Oryzias latipes).	4-nonylphenol	37-50	cellular tumor antigen p53	Oryzias latipes	21-24
31310970-3	2019	Therefore, the present study aimed to investigate the protective blocking effect of apoptosis (deficient P53 gene) on 4-nonylphenol (4-NP)-induced nephrotoxicity of medaka (Oryzias latipes).	4-nonylphenol	118-131	cellular tumor antigen p53	Oryzias latipes	105-108
31310970-3	2019	Therefore, the present study aimed to investigate the protective blocking effect of apoptosis (deficient P53 gene) on 4-nonylphenol (4-NP)-induced nephrotoxicity of medaka (Oryzias latipes).	4-nonylphenol	133-137	cellular tumor antigen p53	Oryzias latipes	105-108
31310970-7	2019	As p53 is an apoptotic inducer, some protection in p53-deficient medaka was found as nephrotoxic effects of 4-NP were minimized significantly.	4-nonylphenol	108-112	cellular tumor antigen p53	Oryzias latipes	3-6
31310970-7	2019	As p53 is an apoptotic inducer, some protection in p53-deficient medaka was found as nephrotoxic effects of 4-NP were minimized significantly.	4-nonylphenol	108-112	cellular tumor antigen p53	Oryzias latipes	51-54
31398569-7	2019	The first order reaction rate constant is 0.0332 min-1, 586.5, 202.4 and 31.9 times that on SnS2, CQDs-SnS2 and Pd-SnS2 in the condition of 20 mg L-1 4-NP and excess NaBH4, respectively.	4-nonylphenol	150-154	sodium voltage-gated channel alpha subunit 11	Homo sapiens	92-96
31398569-7	2019	The first order reaction rate constant is 0.0332 min-1, 586.5, 202.4 and 31.9 times that on SnS2, CQDs-SnS2 and Pd-SnS2 in the condition of 20 mg L-1 4-NP and excess NaBH4, respectively.	4-nonylphenol	150-154	sodium voltage-gated channel alpha subunit 11	Homo sapiens	103-107
31398569-7	2019	The first order reaction rate constant is 0.0332 min-1, 586.5, 202.4 and 31.9 times that on SnS2, CQDs-SnS2 and Pd-SnS2 in the condition of 20 mg L-1 4-NP and excess NaBH4, respectively.	4-nonylphenol	150-154	sodium voltage-gated channel alpha subunit 11	Homo sapiens	103-107
30954815-2	2019	Thus, this study aimed to understand the role of subsoil SOC in sorption processes of 4-n-nonylphenol (NP) and perfluorooctanoic acid (PFOA) as model pollutants.	4-nonylphenol	86-101	UBX domain protein 11	Homo sapiens	57-60
31144530-0	2019	4-Nonylphenol-enhanced EZH2 and RNF2 expression, H3K27me3 and H2AK119ub1 marks resulting in silencing of p21CDKN1A in vitro.	4-nonylphenol	0-13	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	23-27
30818265-4	2019	The degradation efficiency of 4-NP (85%) was achieved at pH 3.0 using an initial dosage of 3.33 g L-1 Fe3O4-BB and 2.3 x 10-5 M persulfate (PS) in a biochar-sediment system.	4-nonylphenol	30-34	immunoglobulin kappa variable 3-15	Homo sapiens	98-116
31144530-0	2019	4-Nonylphenol-enhanced EZH2 and RNF2 expression, H3K27me3 and H2AK119ub1 marks resulting in silencing of p21CDKN1A in vitro.	4-nonylphenol	0-13	ring finger protein 2	Homo sapiens	32-36
31144530-5	2019	Selective inhibition of RNF2 or EZH2 reverted the 4-NP action.	4-nonylphenol	50-54	ring finger protein 2	Homo sapiens	24-28
31144530-5	2019	Selective inhibition of RNF2 or EZH2 reverted the 4-NP action.	4-nonylphenol	50-54	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	32-36
30594011-5	2019	The limits of detection were approximately 0.011 mug L-1 of tetrabromobisphenol A and 0.017 mug L-1 of 4-nonylphenol.	4-nonylphenol	103-116	immunoglobulin kappa variable 1-16	Homo sapiens	96-99
28041982-4	2017	Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis.	4-nonylphenol	36-38	autophagy related 7	Rattus norvegicus	215-219
30090582-1	2018	Objective: To explore the effects of different dosages of 4-nonylphenol (4-NP) on the fatty acid synthesis and estrogen receptor alpha (ERalpha) expression in the livers of F1 and F2 rats.	4-nonylphenol	58-71	estrogen receptor 1	Rattus norvegicus	136-143
27087316-0	2017	4-Nonylphenol induces disruption of spermatogenesis associated with oxidative stress-related apoptosis by targeting p53-Bcl-2/Bax-Fas/FasL signaling.	4-nonylphenol	0-13	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	116-119
27087316-0	2017	4-Nonylphenol induces disruption of spermatogenesis associated with oxidative stress-related apoptosis by targeting p53-Bcl-2/Bax-Fas/FasL signaling.	4-nonylphenol	0-13	BCL2, apoptosis regulator	Rattus norvegicus	120-125
27087316-0	2017	4-Nonylphenol induces disruption of spermatogenesis associated with oxidative stress-related apoptosis by targeting p53-Bcl-2/Bax-Fas/FasL signaling.	4-nonylphenol	0-13	BCL2 associated X, apoptosis regulator	Rattus norvegicus	126-129
27087316-0	2017	4-Nonylphenol induces disruption of spermatogenesis associated with oxidative stress-related apoptosis by targeting p53-Bcl-2/Bax-Fas/FasL signaling.	4-nonylphenol	0-13	Fas ligand	Rattus norvegicus	134-138
28041982-0	2017	4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.	4-nonylphenol	0-13	mechanistic target of rapamycin kinase	Rattus norvegicus	47-51
28041982-0	2017	4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.	4-nonylphenol	0-13	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	89-93
29558393-6	2018	The results of the in vitro effects of commonly found EDCs, particularly Bisphenol A (BPA) and para-Nonylphenol (p-NP), indicate that these substances can alter hCG production and through this action could exert their fetal damage, suggesting that hCG could represent and become a potentially useful clinical biomarker of an inappropriate prenatal exposure to these substances.	4-nonylphenol	95-111	chorionic gonadotropin subunit beta 5	Homo sapiens	161-164
29558393-6	2018	The results of the in vitro effects of commonly found EDCs, particularly Bisphenol A (BPA) and para-Nonylphenol (p-NP), indicate that these substances can alter hCG production and through this action could exert their fetal damage, suggesting that hCG could represent and become a potentially useful clinical biomarker of an inappropriate prenatal exposure to these substances.	4-nonylphenol	95-111	chorionic gonadotropin subunit beta 5	Homo sapiens	248-251
29558393-6	2018	The results of the in vitro effects of commonly found EDCs, particularly Bisphenol A (BPA) and para-Nonylphenol (p-NP), indicate that these substances can alter hCG production and through this action could exert their fetal damage, suggesting that hCG could represent and become a potentially useful clinical biomarker of an inappropriate prenatal exposure to these substances.	4-nonylphenol	113-117	chorionic gonadotropin subunit beta 5	Homo sapiens	161-164
29558393-6	2018	The results of the in vitro effects of commonly found EDCs, particularly Bisphenol A (BPA) and para-Nonylphenol (p-NP), indicate that these substances can alter hCG production and through this action could exert their fetal damage, suggesting that hCG could represent and become a potentially useful clinical biomarker of an inappropriate prenatal exposure to these substances.	4-nonylphenol	113-117	chorionic gonadotropin subunit beta 5	Homo sapiens	248-251
28104344-0	2017	In vitro effect of 4-nonylphenol on human chorionic gonadotropin (hCG) stimulated hormone secretion, cell viability and reactive oxygen species generation in mice Leydig cells.	4-nonylphenol	19-32	chorionic gonadotropin subunit beta 5	Homo sapiens	42-70
28041982-4	2017	Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis.	4-nonylphenol	36-38	beclin 1	Rattus norvegicus	132-140
28041982-4	2017	Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis.	4-nonylphenol	36-38	autophagy related 3	Rattus norvegicus	203-207
28041982-4	2017	Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis.	4-nonylphenol	36-38	autophagy related 5	Rattus norvegicus	209-213
28041982-4	2017	Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis.	4-nonylphenol	36-38	autophagy related 12	Rattus norvegicus	224-229
28041982-4	2017	Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis.	4-nonylphenol	36-38	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	298-302
28041982-4	2017	Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis.	4-nonylphenol	36-38	TSC complex subunit 2	Rattus norvegicus	327-331
28041982-4	2017	Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis.	4-nonylphenol	36-38	mechanistic target of rapamycin kinase	Rattus norvegicus	332-336
27036933-0	2016	The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures.	4-nonylphenol	35-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	84-89
28920386-2	2016	In the present study, 4-nitrophenol(4-NP) and beta-estradiol were elected as substrates to determine activities of UGTs and UGT1A1 by UV and HPLC.	4-nonylphenol	36-40	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-130
27036933-3	2016	Environmental xenoestrogens, like bisphenol A (BPA) and p-nonylphenol (p-NP), mimic natural estrogens and can affect hormonal systems.	4-nonylphenol	56-69	purine nucleoside phosphorylase	Homo sapiens	71-75
25998160-7	2015	In addition, 4-nonylphenol induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1).	4-nonylphenol	13-26	caspase 3	Homo sapiens	74-83
26931663-0	2016	Reconstruction of the pollution history of alkylphenols (4-tert-octylphenol, 4-nonylphenol) in the Baltic Sea.	4-nonylphenol	77-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	106-109
26931663-1	2016	This paper reports the reconstruction of the pollution history of 4-tert-octylphenol (OP) and 4-nonylphenol (NP) in the Baltic Sea.	4-nonylphenol	94-107	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
26931663-1	2016	This paper reports the reconstruction of the pollution history of 4-tert-octylphenol (OP) and 4-nonylphenol (NP) in the Baltic Sea.	4-nonylphenol	109-111	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
26804764-0	2016	4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.	4-nonylphenol	0-13	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
26804764-0	2016	4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.	4-nonylphenol	0-13	mechanistic target of rapamycin kinase	Rattus norvegicus	111-115
26804764-0	2016	4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.	4-nonylphenol	0-13	mitogen-activated protein kinase 8	Rattus norvegicus	120-123
27550319-4	2016	Here, we show that very high concentrations of para-nonylphenol (50-100 muM) induce apoptosis in U937 human monocyte leukemia cells in a dose-dependent manner.	4-nonylphenol	47-63	latexin	Homo sapiens	72-75
27550319-8	2016	RESULTS: Treatment with > 50 muM para-nonylphenol induced apoptosis in U937 monocyte cells and MCF- 7 and MDA-MB231 human breast cancer cells.	4-nonylphenol	36-52	latexin	Homo sapiens	32-35
27550319-11	2016	Para-nonylphenol decreased the levels of activated AKT and increased the levels of activated JNK/SAPK at 15 min after treatment.	4-nonylphenol	0-16	AKT serine/threonine kinase 1	Homo sapiens	51-54
27550319-11	2016	Para-nonylphenol decreased the levels of activated AKT and increased the levels of activated JNK/SAPK at 15 min after treatment.	4-nonylphenol	0-16	mitogen-activated protein kinase 8	Homo sapiens	93-101
23771873-5	2015	Plasma VTG levels in 4-NP-treated fish were detected by sodium dodecyl sulfate polyacrylamide gel electrophoresis as a high molecular weight protein band of 180 KDa.	4-nonylphenol	21-25	LOC100136735	Oncorhynchus mykiss	7-10
25998160-7	2015	In addition, 4-nonylphenol induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1).	4-nonylphenol	13-26	heat shock protein family A (Hsp70) member 5	Homo sapiens	175-180
25998160-7	2015	In addition, 4-nonylphenol induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1).	4-nonylphenol	13-26	heat shock protein family A (Hsp70) member 5	Homo sapiens	182-214
25998160-7	2015	In addition, 4-nonylphenol induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1).	4-nonylphenol	13-26	X-box binding protein 1	Homo sapiens	234-238
25998160-7	2015	In addition, 4-nonylphenol induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of GRP78 (78 kDa glucose-regulated protein) and activation of XBP1 (X-box binding protein-1).	4-nonylphenol	13-26	X-box binding protein 1	Homo sapiens	240-263
25162503-1	2015	We aimed to investigate the effects and mechanisms of action of p-nonylphenol(p-NP) on uterine contractility in rats.	4-nonylphenol	64-77	purine nucleoside phosphorylase	Rattus norvegicus	78-82
25251932-4	2015	Accordingly, the AhR agonist 4-n-nonylphenol (NP) suppressed sensitization and induced Treg similar to UVR.	4-nonylphenol	29-44	aryl-hydrocarbon receptor	Mus musculus	17-20
25251932-4	2015	Accordingly, the AhR agonist 4-n-nonylphenol (NP) suppressed sensitization and induced Treg similar to UVR.	4-nonylphenol	46-48	aryl-hydrocarbon receptor	Mus musculus	17-20
25251932-7	2015	NP induced the release of IL-2 by DC that subsequently triggered the release of IL-10.	4-nonylphenol	0-2	interleukin 2	Mus musculus	26-30
25251932-7	2015	NP induced the release of IL-2 by DC that subsequently triggered the release of IL-10.	4-nonylphenol	0-2	interleukin 10	Mus musculus	80-85
24460192-8	2014	The effects of BPA and 4-NP on cell motility were inhibited by the Lpar1 or Lpar3 knockdown.	4-nonylphenol	23-27	lysophosphatidic acid receptor 1	Rattus norvegicus	67-72
24460192-8	2014	The effects of BPA and 4-NP on cell motility were inhibited by the Lpar1 or Lpar3 knockdown.	4-nonylphenol	23-27	lysophosphatidic acid receptor 3	Rattus norvegicus	76-81
23652795-7	2013	Conversely, activation of the AhR by the agonist 4-n-nonylphenol (NP) suppressed the induction of CHS and induced antigen-specific Tregs similar to UVR.	4-nonylphenol	49-64	aryl-hydrocarbon receptor	Mus musculus	30-33
23652795-7	2013	Conversely, activation of the AhR by the agonist 4-n-nonylphenol (NP) suppressed the induction of CHS and induced antigen-specific Tregs similar to UVR.	4-nonylphenol	66-68	aryl-hydrocarbon receptor	Mus musculus	30-33
24054583-5	2013	The response currents of the imprinted electrode exhibited a linear relationship toward 4-nonylphenol concentration ranging from 1.0 x 10(-11) to 1.0 x 10(-8) gm L(-1) with the detection limit of 3.5 x 10(-12) gm L(-1) (S/N=3).	4-nonylphenol	88-101	immunoglobulin kappa variable 1-16	Homo sapiens	162-167
24054583-5	2013	The response currents of the imprinted electrode exhibited a linear relationship toward 4-nonylphenol concentration ranging from 1.0 x 10(-11) to 1.0 x 10(-8) gm L(-1) with the detection limit of 3.5 x 10(-12) gm L(-1) (S/N=3).	4-nonylphenol	88-101	immunoglobulin kappa variable 1-16	Homo sapiens	213-218
21598197-2	2011	A computer-aided docking study was conducted to explore in detail the binding interactions between the structurally unlikely environmental oestrogen 4-nonylphenol (4NP) and three of its metabolites with the human oestrogen receptor alpha (hERalpha).	4-nonylphenol	149-162	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	239-247
23719487-0	2013	Reproductive toxicity effects of 4-nonylphenol with known endocrine disrupting effects and induction of vitellogenin gene expression in silkworm, Bombyx mori.	4-nonylphenol	33-46	vitellogenin	Bombyx mori	104-116
23621474-9	2013	CONCLUSION: These results suggested that NP may disturb physiologic function of DCs through, in part, AhR-dependent mechanisms, supporting the importance of NP exposure on the regulation of DC functions and allergic inflammation.	4-nonylphenol	41-43	aryl-hydrocarbon receptor	Mus musculus	102-105
22414680-11	2012	The agonistic effect of progesterone on SULT1E1 mRNA was concentration-dependently antagonized by RU486 (mifepristone) and ZK137316 and, with lower potency, by 4-nonylphenol, bisphenol A and apigenin.	4-nonylphenol	160-173	sulfotransferase family 1E member 1	Homo sapiens	40-47
22278595-8	2012	GS/mPHP/Au hybrids are also used as efficient heterogeneous catalysts for the reduction of 4-NP, and demonstrate excellent catalytic performance.	4-nonylphenol	91-95	phosphohistidine phosphatase 1	Mus musculus	3-7
22056370-2	2011	Incubation of the cells with 4-NP at 10(-5)M and 10(-6)M striking decreased osteoblasts viability and phosphatidylserine (PS) exposure, measured by Annexin V, was greatly enhanced.	4-nonylphenol	29-33	annexin A5	Mus musculus	148-157
22056370-4	2011	Interestingly, treatment with 4-NP was also able to increase cleaved caspase 8 in parallel with the truncated active Bid (t-Bid) suggesting that 4-NP-mediated apoptosis depends on cross talk between the extrinsic and intrinsic pathways.	4-nonylphenol	30-34	caspase 8	Mus musculus	69-78
22056370-4	2011	Interestingly, treatment with 4-NP was also able to increase cleaved caspase 8 in parallel with the truncated active Bid (t-Bid) suggesting that 4-NP-mediated apoptosis depends on cross talk between the extrinsic and intrinsic pathways.	4-nonylphenol	30-34	BH3 interacting domain death agonist	Mus musculus	117-120
22056370-4	2011	Interestingly, treatment with 4-NP was also able to increase cleaved caspase 8 in parallel with the truncated active Bid (t-Bid) suggesting that 4-NP-mediated apoptosis depends on cross talk between the extrinsic and intrinsic pathways.	4-nonylphenol	30-34	BH3 interacting domain death agonist	Mus musculus	124-127
22056370-4	2011	Interestingly, treatment with 4-NP was also able to increase cleaved caspase 8 in parallel with the truncated active Bid (t-Bid) suggesting that 4-NP-mediated apoptosis depends on cross talk between the extrinsic and intrinsic pathways.	4-nonylphenol	145-149	caspase 8	Mus musculus	69-78
22056370-4	2011	Interestingly, treatment with 4-NP was also able to increase cleaved caspase 8 in parallel with the truncated active Bid (t-Bid) suggesting that 4-NP-mediated apoptosis depends on cross talk between the extrinsic and intrinsic pathways.	4-nonylphenol	145-149	BH3 interacting domain death agonist	Mus musculus	117-120
22056370-4	2011	Interestingly, treatment with 4-NP was also able to increase cleaved caspase 8 in parallel with the truncated active Bid (t-Bid) suggesting that 4-NP-mediated apoptosis depends on cross talk between the extrinsic and intrinsic pathways.	4-nonylphenol	145-149	BH3 interacting domain death agonist	Mus musculus	124-127
24278580-0	2011	Cell Growth of BG-1 Ovarian Cancer Cells was Promoted by 4-Tert-octylphenol and 4-Nonylphenol via Downregulation of TGF-beta Receptor 2 and Upregulation of c-myc.	4-nonylphenol	80-93	transforming growth factor beta 1	Homo sapiens	116-124
24278580-0	2011	Cell Growth of BG-1 Ovarian Cancer Cells was Promoted by 4-Tert-octylphenol and 4-Nonylphenol via Downregulation of TGF-beta Receptor 2 and Upregulation of c-myc.	4-nonylphenol	80-93	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	156-161
23416871-0	2013	Binding of the endocrine disruptors 4-tert-octylphenol and 4-nonylphenol to human serum albumin.	4-nonylphenol	59-72	albumin	Homo sapiens	82-95
23416871-2	2013	In this paper, to evaluate the toxicity of the alkylphenols at the protein level, the effects of 4-tert-octylphenol (OP) and 4-nonylphenol (NP) on human serum albumin (HSA) were characterized by molecular modeling, steady state and time-resolved fluorescence, ultraviolet-visible spectroscopy (UV-vis) and circular dichroism spectroscopy (CD).	4-nonylphenol	140-142	albumin	Homo sapiens	153-166
21598197-2	2011	A computer-aided docking study was conducted to explore in detail the binding interactions between the structurally unlikely environmental oestrogen 4-nonylphenol (4NP) and three of its metabolites with the human oestrogen receptor alpha (hERalpha).	4-nonylphenol	164-167	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	239-247
21598197-5	2011	This study has revealed unconventional interactions between the ligands and the hERalpha binding pocket that could explain the observed oestrogen-like behaviour of 4NP and suggests some of the metabolites of 4NP may also be oestrogenic.	4-nonylphenol	164-167	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	80-88
21598197-5	2011	This study has revealed unconventional interactions between the ligands and the hERalpha binding pocket that could explain the observed oestrogen-like behaviour of 4NP and suggests some of the metabolites of 4NP may also be oestrogenic.	4-nonylphenol	208-211	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	80-88
21348526-8	2011	Estrone, 17beta-estradiol, 9H-benz[de]anthracen-7-one, and 4-nonylphenol were identified as possible estrogenic and TTR-binding compounds.	4-nonylphenol	59-72	transthyretin	Homo sapiens	116-119
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	toll like receptor 10	Homo sapiens	129-135
20452023-0	2010	Simultaneous determination and assessment of 4-nonylphenol, bisphenol A and triclosan in tap water, bottled water and baby bottles.	4-nonylphenol	45-58	nuclear RNA export factor 1	Homo sapiens	89-92
20452023-5	2010	The highest concentrations in tap water for 4-NP, BPA and TCS were 1987, 317 and 14.5ng/L, respectively.	4-nonylphenol	44-48	nuclear RNA export factor 1	Homo sapiens	30-33
20452023-6	2010	Daily intakes of 4-NP, BPA and TCS of adults by drinking 2L of tap water were estimated to be 1410, 148 and 10 ng/day, respectively.	4-nonylphenol	17-21	nuclear RNA export factor 1	Homo sapiens	63-66
20534002-8	2010	Fluorescent recovery after photobleaching of hippocampal neurons showed that pregnenolone and agonistic EDCs enhanced, but that 4-nonylphenol inhibited the MAP2-mediated neurite outgrowth in a progesterone- or antagonistic EDC-reversible manner.	4-nonylphenol	128-141	microtubule associated protein 2	Homo sapiens	156-160
20452023-8	2010	Estimated daily intakes of 4-NP, BPA and TCS for infants were 705, 1340 and 5 ng/day, respectively, by drinking 1L of tap water from a baby bottle at 40 degrees C. This study showed that the exposure to the three compounds from drinking water is unlikely to pose a health risk.	4-nonylphenol	27-31	nuclear RNA export factor 1	Homo sapiens	118-121
20436506-2	2010	This study aimed to use a computerized docking approach to examine the interactions between the human AR and phyto-oestrogens (genistein, daidzein, and flavone) and xeno-oestrogens (bisphenol A, 4-nonylphenol, dichlorodiphenyl trichloroethane [DDT], diethylstilbestrol [DES]).	4-nonylphenol	195-208	androgen receptor	Homo sapiens	102-104
20436506-10	2010	Another two xeno-oestrogens, 4-nonylphenol and DDT, although they fit within the binding domain of AR, showed weak affinity (-6.4 and -6.7 kcal mol(-1), respectively).	4-nonylphenol	29-42	androgen receptor	Homo sapiens	99-101
20436506-12	2010	The xeno-oestrogens DDT and 4-nonylphenol bind only weakly to AR.	4-nonylphenol	28-41	androgen receptor	Homo sapiens	62-64
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	interleukin 5	Homo sapiens	157-161
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	interleukin 6	Homo sapiens	163-167
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	interleukin 23 subunit alpha	Homo sapiens	177-183
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	C-X-C motif chemokine receptor 2	Homo sapiens	185-191
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	interleukin 1 receptor associated kinase 2	Homo sapiens	224-230
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	TNF receptor superfamily member 1A	Homo sapiens	233-263
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	TNF receptor superfamily member 1A	Homo sapiens	265-269
22371766-4	2010	RESULTS: It was determined that 4-NP significantly up-regulated proinflammatory cytokine expression (toll-like-receptor [TLR]-6, TLR-10, interleukin [IL]-1, IL-5, IL-6, IL-17C, IL-23A, IL-8RB, IL-receptor-associated-kinase [IRAK-2], tumor-necrosis-factor-receptor [TNFR]-5, and TNFR-10).	4-nonylphenol	32-36	TNF receptor superfamily member 1A	Homo sapiens	278-282
22371766-6	2010	Simultaneously, 4-NP down-regulated the expression of anti-inflammatory cytokines (IL-4 and IL-10), while estrogen up-regulated them.	4-nonylphenol	16-20	interleukin 4	Homo sapiens	83-87
22371766-6	2010	Simultaneously, 4-NP down-regulated the expression of anti-inflammatory cytokines (IL-4 and IL-10), while estrogen up-regulated them.	4-nonylphenol	16-20	interleukin 10	Homo sapiens	92-97
16386813-1	2006	The present study examined the antioxidant effects of angiotensin-converting enzyme inhibitor (ACE), imidaprilat, on para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum, using a microdialysis technique.	4-nonylphenol	117-133	angiotensin I converting enzyme	Rattus norvegicus	54-93
17950039-5	2008	After exposure of K. marmoratus to endocrine disrupting chemicals (EDCs) such as bisphenol A, 4-nonylphenol, and 4-tert-octylphenol, Km-p53 expression was significantly increased within 3 h of exposure in juveniles.	4-nonylphenol	94-107	cellular tumor antigen p53	Kryptolebias marmoratus	136-139
18162324-3	2008	Here we report that p-nonylphenol, one of the EDCs, induced apoptosis with up-regulation of glucose-regulated protein 78 (GRP78) expression and activation of caspase-12, which are involved in endoplasmic reticulum (ER) stress specific phenomena, in NGF-treated neuronally differentiated PC12 cells.	4-nonylphenol	20-33	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	92-120
18162324-3	2008	Here we report that p-nonylphenol, one of the EDCs, induced apoptosis with up-regulation of glucose-regulated protein 78 (GRP78) expression and activation of caspase-12, which are involved in endoplasmic reticulum (ER) stress specific phenomena, in NGF-treated neuronally differentiated PC12 cells.	4-nonylphenol	20-33	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	122-127
18162324-3	2008	Here we report that p-nonylphenol, one of the EDCs, induced apoptosis with up-regulation of glucose-regulated protein 78 (GRP78) expression and activation of caspase-12, which are involved in endoplasmic reticulum (ER) stress specific phenomena, in NGF-treated neuronally differentiated PC12 cells.	4-nonylphenol	20-33	caspase 12	Rattus norvegicus	158-168
18162324-5	2008	Intriguingly, we also discovered that decreased phosphorylation of ERK1/2 was induced by p-nonylphenol in the presence of NGF, whereas p-nonylphenol alone did not induce phosphorylation of ERK1/2.	4-nonylphenol	89-102	mitogen activated protein kinase 3	Rattus norvegicus	67-73
18162324-6	2008	These lines of evidence suggest that p-nonylphenol can induce ER stress-mediated apoptosis via increased intracellular Ca(2+) concentration, and can reduce ERK1/2 phosphorylation to attenuate the cell survival effect of NGF, in neuronally differentiated PC12 cells.	4-nonylphenol	37-50	mitogen activated protein kinase 3	Rattus norvegicus	156-162
17356815-4	2007	NP-G and OP-G were deconjugated, becoming free 4-nonylphenol (NP) and 4-tert-octylphenol (OP).	4-nonylphenol	47-60	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	0-13
17304841-3	2006	The result showed that the recombinant gene yeast had steroid specificity and dose-respond curve for progesterone with EC50 value of 0.5 nmol/L; The estrogenic chemicals pentachlorophenol and p-nonylphenol inhibited the activity of hPR in the yeast which had IC50 values of 2.4 micromol/L and 3.7 micromol/L, respectively.	4-nonylphenol	192-205	haptoglobin-related protein	Homo sapiens	232-235
16790488-1	2006	p-Nonylphenol (p-NP) is a metabolite of alkylphenol ethoxylates used as surfactants in the manufacturing industry.	4-nonylphenol	0-13	purine nucleoside phosphorylase	Homo sapiens	15-19
16705041-0	2006	Effects of 4-n-nonylphenol and tamoxifen on salmon gonadotropin-releasing hormone, estrogen receptor, and vitellogenin gene expression in juvenile rainbow trout.	4-nonylphenol	11-26	LOC100136735	Oncorhynchus mykiss	106-118
16759644-1	2006	To uncover the effect of estrogenic chemicals [4-nonylphenol (NP) and bisphenol A (BisA)] on the expression of androgen receptor (AR) and estrogen receptors (ERalpha and ERbeta) in the hermaphroditic fish Rivulus marmoratus, we cloned the full length of the cDNAs encoding AR, ERalpha, and ERbeta from gonadal tissue of R. marmoratus and analyzed the modulation of expression of these genes following exposure to estrogenic chemicals using real-time RT-PCR.	4-nonylphenol	47-60	estrogen receptor	Kryptolebias marmoratus	158-165
16759644-1	2006	To uncover the effect of estrogenic chemicals [4-nonylphenol (NP) and bisphenol A (BisA)] on the expression of androgen receptor (AR) and estrogen receptors (ERalpha and ERbeta) in the hermaphroditic fish Rivulus marmoratus, we cloned the full length of the cDNAs encoding AR, ERalpha, and ERbeta from gonadal tissue of R. marmoratus and analyzed the modulation of expression of these genes following exposure to estrogenic chemicals using real-time RT-PCR.	4-nonylphenol	47-60	estrogen receptor 2a	Kryptolebias marmoratus	170-176
16759644-1	2006	To uncover the effect of estrogenic chemicals [4-nonylphenol (NP) and bisphenol A (BisA)] on the expression of androgen receptor (AR) and estrogen receptors (ERalpha and ERbeta) in the hermaphroditic fish Rivulus marmoratus, we cloned the full length of the cDNAs encoding AR, ERalpha, and ERbeta from gonadal tissue of R. marmoratus and analyzed the modulation of expression of these genes following exposure to estrogenic chemicals using real-time RT-PCR.	4-nonylphenol	62-64	estrogen receptor	Kryptolebias marmoratus	158-165
16759644-1	2006	To uncover the effect of estrogenic chemicals [4-nonylphenol (NP) and bisphenol A (BisA)] on the expression of androgen receptor (AR) and estrogen receptors (ERalpha and ERbeta) in the hermaphroditic fish Rivulus marmoratus, we cloned the full length of the cDNAs encoding AR, ERalpha, and ERbeta from gonadal tissue of R. marmoratus and analyzed the modulation of expression of these genes following exposure to estrogenic chemicals using real-time RT-PCR.	4-nonylphenol	62-64	estrogen receptor 2a	Kryptolebias marmoratus	170-176
16759644-1	2006	To uncover the effect of estrogenic chemicals [4-nonylphenol (NP) and bisphenol A (BisA)] on the expression of androgen receptor (AR) and estrogen receptors (ERalpha and ERbeta) in the hermaphroditic fish Rivulus marmoratus, we cloned the full length of the cDNAs encoding AR, ERalpha, and ERbeta from gonadal tissue of R. marmoratus and analyzed the modulation of expression of these genes following exposure to estrogenic chemicals using real-time RT-PCR.	4-nonylphenol	62-64	estrogen receptor	Kryptolebias marmoratus	277-284
16759644-1	2006	To uncover the effect of estrogenic chemicals [4-nonylphenol (NP) and bisphenol A (BisA)] on the expression of androgen receptor (AR) and estrogen receptors (ERalpha and ERbeta) in the hermaphroditic fish Rivulus marmoratus, we cloned the full length of the cDNAs encoding AR, ERalpha, and ERbeta from gonadal tissue of R. marmoratus and analyzed the modulation of expression of these genes following exposure to estrogenic chemicals using real-time RT-PCR.	4-nonylphenol	62-64	estrogen receptor 2a	Kryptolebias marmoratus	290-296
20300630-7	2010	The levels of expression of two of these three ER genes, the esr1 and esr2a were altered in organs such as liver, intestine, brain and testis in response to ligand (E2, diethylstilbestrol or 4-nonylphenol).	4-nonylphenol	191-204	estrogen receptor 1	Danio rerio	61-65
20300630-7	2010	The levels of expression of two of these three ER genes, the esr1 and esr2a were altered in organs such as liver, intestine, brain and testis in response to ligand (E2, diethylstilbestrol or 4-nonylphenol).	4-nonylphenol	191-204	estrogen receptor 2a	Danio rerio	70-75
20300630-9	2010	The conclusions are i) estrogen receptor genes are expressed during early development ii) altered expression of esr genes in response to ligand is dependent on the cellular context; iii) the estrogenic ligand 4-nonylphenol, a manufactured compound commonly found in sewage of water treatment plants, acts as an agonist of the estrogen receptor during development and has both agonist and antagonist properties in tissues of adult fish.	4-nonylphenol	209-222	MYC binding protein 2	Danio rerio	112-115
20954072-0	2010	Upregulation of cyclooxygenase-2 by 4-nonylphenol is mediated through the cyclic amp response element activation pathway.	4-nonylphenol	36-49	prostaglandin-endoperoxide synthase 2	Mus musculus	16-32
19463694-4	2009	Treatment with OP, NP and BPA induced a significant increase in GH gene expression at high and medium doses at 24h.	4-nonylphenol	19-21	gonadotropin releasing hormone receptor	Rattus norvegicus	64-66
16697460-0	2006	The environmental estrogen, 4-nonylphenol modulates brain estrogen-receptor- and aromatase (CYP19) isoforms gene expression patterns in Atlantic salmon (Salmo salar).	4-nonylphenol	28-41	aromatase	Salmo salar	92-97
16716392-0	2006	Cloning of Ki-ras and Ha-ras cDNAs from the hermaphroditic fish Rivulus marmoratus (Cyprinodontiformes, Rivulidae) and its expression after exposure to 4-nonylphenol.	4-nonylphenol	152-165	KRAS proto-oncogene, GTPase	Homo sapiens	11-17
16716392-6	2006	Following 4-NP exposure (300 microg/L), the Rm Ki-ras long form in the liver was significantly expressed, while it was expressed moderately in the ovaries.	4-nonylphenol	10-14	KRAS proto-oncogene, GTPase	Homo sapiens	47-53
16716392-8	2006	In relation to these modulations after 4-NP exposure, we searched the Rm Ha- and Ki-ras promoter regions and found several ERE-half sites, that may be involved in the modulation of ras gene expression following 4-NP exposure.	4-nonylphenol	39-43	KRAS proto-oncogene, GTPase	Homo sapiens	81-87
16707107-9	2006	The brain aromatase rm-cyp19b gene was up-regulated in the brain after 4-nonylphenol (4-NP)-exposure, while the ovarian aromatase rm-cyp19a gene was significantly down-regulated in the gonad.	4-nonylphenol	71-84	brain aromatase-like	Kryptolebias marmoratus	23-29
16707107-9	2006	The brain aromatase rm-cyp19b gene was up-regulated in the brain after 4-nonylphenol (4-NP)-exposure, while the ovarian aromatase rm-cyp19a gene was significantly down-regulated in the gonad.	4-nonylphenol	86-90	brain aromatase-like	Kryptolebias marmoratus	23-29
16046237-5	2006	The rates of apoptosis of the 4-nonylphenol-treated thymocytes increased significantly at 4 and 6 h, which were determined by analysis of hypodiploid cells and FITC-Annexin V and PI double staining.	4-nonylphenol	30-43	annexin A5	Mus musculus	165-174
16386813-1	2006	The present study examined the antioxidant effects of angiotensin-converting enzyme inhibitor (ACE), imidaprilat, on para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum, using a microdialysis technique.	4-nonylphenol	117-133	angiotensin I converting enzyme	Rattus norvegicus	95-98
16406821-0	2006	The xenoestrogen 4-nonylphenol modulates hepatic gene expression of pregnane X receptor, aryl hydrocarbon receptor, CYP3A and CYP1A1 in juvenile Atlantic salmon (Salmo salar).	4-nonylphenol	17-30	aryl hydrocarbon receptor	Salmo salar	89-114
16046237-8	2006	These results suggest that 4-nonylphenol induces thymocyte apoptosis via caspase-3 activation and mitochondrial depolarization.	4-nonylphenol	27-40	caspase 3	Mus musculus	73-82
16406821-0	2006	The xenoestrogen 4-nonylphenol modulates hepatic gene expression of pregnane X receptor, aryl hydrocarbon receptor, CYP3A and CYP1A1 in juvenile Atlantic salmon (Salmo salar).	4-nonylphenol	17-30	cytochrome P450 3A27	Salmo salar	116-121
16406821-0	2006	The xenoestrogen 4-nonylphenol modulates hepatic gene expression of pregnane X receptor, aryl hydrocarbon receptor, CYP3A and CYP1A1 in juvenile Atlantic salmon (Salmo salar).	4-nonylphenol	17-30	cytochrome P450, family 1, subfamily A	Salmo salar	126-132
16169144-4	2005	We investigated BPA, 4-octylphenol (OP) and 4-nonylphenol (NP) for their agonistic and antagonistic activities by the AR reporter gene assay.	4-nonylphenol	44-57	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	118-120
17033158-6	2006	The expression of progesterone receptor mRNA in the anterior pituitary was significantly increased by either NP, OP, bisphenol A, or estradiol, but bisphenol A was less effective.	4-nonylphenol	109-111	progesterone receptor	Rattus norvegicus	18-39
16393665-8	2006	With E2, as well as 4-nonylphenol and the fluorotelomer alcohols, we observed up-regulation of trefoil factor 1, progesterone receptor, and PDZK1 and down-regulation of ERBB2 gene expression.	4-nonylphenol	20-33	progesterone receptor	Homo sapiens	113-134
16393665-8	2006	With E2, as well as 4-nonylphenol and the fluorotelomer alcohols, we observed up-regulation of trefoil factor 1, progesterone receptor, and PDZK1 and down-regulation of ERBB2 gene expression.	4-nonylphenol	20-33	PDZ domain containing 1	Homo sapiens	140-145
16393665-8	2006	With E2, as well as 4-nonylphenol and the fluorotelomer alcohols, we observed up-regulation of trefoil factor 1, progesterone receptor, and PDZK1 and down-regulation of ERBB2 gene expression.	4-nonylphenol	20-33	erb-b2 receptor tyrosine kinase 2	Homo sapiens	169-174
16169144-4	2005	We investigated BPA, 4-octylphenol (OP) and 4-nonylphenol (NP) for their agonistic and antagonistic activities by the AR reporter gene assay.	4-nonylphenol	59-61	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	118-120
16617682-8	2005	Furthermore non-halogenated compounds among these phenolic compounds, such as BPA, p-octylphenol, and p-nonylphenol, showed inhibitory effects on the isomerase activity of PDI.	4-nonylphenol	102-115	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	172-175
15234545-13	2004	These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR.	4-nonylphenol	27-42	negative elongation factor complex member C/D, Th1l	Mus musculus	81-84
16402549-0	2005	Metabolism of 4-n-nonylphenol by non-modified and CYP1A1- and CYP1A2-transgenic cell cultures of tobacco.	4-nonylphenol	14-29	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	62-68
15792627-6	2005	Western blots and testosterone 6beta-hydroxylation indicated that CYP3A was increased 50% by 4-NP, but was not affected by SJW.	4-nonylphenol	93-97	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-71
16013040-3	2005	4-Nonylphenol (4-NP) is an environmental estrogen that also can activate the pregnane-X receptor (PXR) and induce P-450 enzymes responsible for the production of E3.	4-nonylphenol	0-13	nuclear receptor subfamily 1, group I, member 2	Mus musculus	77-96
16013040-3	2005	4-Nonylphenol (4-NP) is an environmental estrogen that also can activate the pregnane-X receptor (PXR) and induce P-450 enzymes responsible for the production of E3.	4-nonylphenol	0-13	nuclear receptor subfamily 1, group I, member 2	Mus musculus	98-101
16013040-3	2005	4-Nonylphenol (4-NP) is an environmental estrogen that also can activate the pregnane-X receptor (PXR) and induce P-450 enzymes responsible for the production of E3.	4-nonylphenol	15-19	nuclear receptor subfamily 1, group I, member 2	Mus musculus	77-96
16013040-3	2005	4-Nonylphenol (4-NP) is an environmental estrogen that also can activate the pregnane-X receptor (PXR) and induce P-450 enzymes responsible for the production of E3.	4-nonylphenol	15-19	nuclear receptor subfamily 1, group I, member 2	Mus musculus	98-101
16023680-8	2005	We exposed R. marmoratus to 4-nonylphenol, and found a small induction of CYP1A mRNA in the treated animals.	4-nonylphenol	28-41	cytochrome P450 1A1	Kryptolebias marmoratus	74-79
15526264-8	2004	Target chemical analyses showed that the water, sediment, and serum samples tested positive for p-nonylphenol (p-NP).	4-nonylphenol	96-109	purine nucleoside phosphorylase	Homo sapiens	111-115
15234545-8	2004	In both systems, 1-10 microM of p-n-nonylphenol suppressed Th1 development and enhanced Th2 development, whereas estrogen by itself failed to affect Th1/Th2 development.	4-nonylphenol	32-47	negative elongation factor complex member C/D, Th1l	Mus musculus	59-62
15234545-13	2004	These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR.	4-nonylphenol	27-42	heart and neural crest derivatives expressed 2	Mus musculus	109-112
15234545-8	2004	In both systems, 1-10 microM of p-n-nonylphenol suppressed Th1 development and enhanced Th2 development, whereas estrogen by itself failed to affect Th1/Th2 development.	4-nonylphenol	32-47	heart and neural crest derivatives expressed 2	Mus musculus	88-91
15234545-13	2004	These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR.	4-nonylphenol	27-42	progesterone receptor	Mus musculus	189-193
15234545-13	2004	These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR.	4-nonylphenol	27-42	nuclear receptor subfamily 3, group C, member 1	Mus musculus	199-202
15081833-11	2004	The alkylphenolic compounds (4-octylphenol and 4-nonylphenol) displayed some ability to displace 3H-E2 binding from ERalpha and beta at high concentrations, but dieldrin and atrazine had little binding activity for both ER subtypes and endosulfan for ERbeta.	4-nonylphenol	47-60	estrogen receptor	Ictalurus punctatus	116-132
15081833-11	2004	The alkylphenolic compounds (4-octylphenol and 4-nonylphenol) displayed some ability to displace 3H-E2 binding from ERalpha and beta at high concentrations, but dieldrin and atrazine had little binding activity for both ER subtypes and endosulfan for ERbeta.	4-nonylphenol	47-60	estrogen receptor beta	Ictalurus punctatus	251-257
14664910-5	2003	In cortical neurons, BPA and NP significantly inhibited the increase in caspase-3 activity, while E2 did not.	4-nonylphenol	29-31	caspase 3	Rattus norvegicus	72-81
15009642-5	2004	Furthermore, an exposure to 4-nonylphenol led to the accumulation of cells at the G2/M phase interface and down-regulated the protein levels of cyclin A and B1, which are the major regulatory proteins at the G2 to M transition of the cell cycle.	4-nonylphenol	28-41	cyclin A2	Homo sapiens	144-159
15064160-5	2004	Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase inhibitor, diphenyl iodonium chloride and the myeloperoxidase inhibitor sodium azide (NaN3) showed remarkable inhibitory effects on ROS generation induced by NP, but an inhibitor against mitochondrial respiratory function, potassium cyanide (KCN), did not exhibit significant effect.	4-nonylphenol	236-238	myeloperoxidase	Homo sapiens	124-139
14763995-0	2004	p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats.	4-nonylphenol	0-13	progesterone receptor	Rattus norvegicus	77-98
12062158-9	2002	The highest dose of NP (125 mg/kg BW) significantly induced Pit-1 mRNA in males (P<0.01).	4-nonylphenol	20-22	pituitary-specific positive transcription factor 1	Salmo salar	60-65
14709801-11	2003	Only NPH at a dose likely too high to be of any physiological relevance induced a severe cytotoxicity in an ERalpha-independent manner as ascertained in HeLa cells.	4-nonylphenol	5-8	estrogen receptor 1	Homo sapiens	108-115
12919000-5	2003	Comparative studies showed that MWNTs were superior to C18 for the extraction of the more polar analyte bisphenol A and at least as effective as C18 for the extraction of 4-n-nonylphenol and 4-tert-octylphenol.	4-nonylphenol	171-186	Bardet-Biedl syndrome 9	Homo sapiens	145-148
12547330-1	2003	In this study, we tested phenolic compounds such as bisphenol A (BPA), 4-nonylphenol (NP), 4-octylphenol (OP) and 4-propylphenol (PP) by using glucose-6-phosphate dehydrogenase (G6PD) in estrogen sensitive human breast cancer cells (MCF-7 cells) and glutathione peroxidase (GPx) in female immature Sprague-Dawley (SD) rats.	4-nonylphenol	71-84	glucose-6-phosphate dehydrogenase	Homo sapiens	143-176
14709801-0	2003	The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells.	4-nonylphenol	38-51	estrogen receptor 1	Homo sapiens	72-95
12709020-4	2003	Both BPA and NP significantly enhanced IL-4 production in keyhole limpet haemocyanin (KLH)-primed CD4+ T cells in a concentration-dependent manner.	4-nonylphenol	13-15	interleukin 4	Mus musculus	39-43
12709020-5	2003	Treatment with BPA or NP in vivo resulted in significant increase of IL-4 production in CD4+ T cells and of antigen-specific immunoglobulin E (IgE) levels in the sera of KLH-primed mice.	4-nonylphenol	22-24	interleukin 4	Mus musculus	69-73
12709020-8	2003	The enhancement of IL-4 production by BPA or NP was significantly reduced by nitrendipine, a blocker of Ca2+ influx, and by FK506, a calcineurin inhibitor.	4-nonylphenol	45-47	interleukin 4	Mus musculus	19-23
11936222-7	2002	4-t-Octylphenol and 4-nonylphenol inhibited the binding of E2 to the ER of MCF-7 cells in a competitive ER binding assay.	4-nonylphenol	20-33	estrogen receptor 1	Homo sapiens	69-71
12061770-0	2002	Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha expression by 4-nonylphenol in macrophages.	4-nonylphenol	93-106	tumor necrosis factor	Mus musculus	51-78
12061770-4	2002	In contrast, NP inhibited lipopolysaccharide (LPS)-induced NO and TNF-alpha production, and the levels of iNOS and TNF-alpha mRNA in a dose-dependent manner.	4-nonylphenol	13-15	tumor necrosis factor	Mus musculus	66-75
12061770-4	2002	In contrast, NP inhibited lipopolysaccharide (LPS)-induced NO and TNF-alpha production, and the levels of iNOS and TNF-alpha mRNA in a dose-dependent manner.	4-nonylphenol	13-15	nitric oxide synthase 2, inducible	Mus musculus	106-110
12061770-4	2002	In contrast, NP inhibited lipopolysaccharide (LPS)-induced NO and TNF-alpha production, and the levels of iNOS and TNF-alpha mRNA in a dose-dependent manner.	4-nonylphenol	13-15	tumor necrosis factor	Mus musculus	115-124
12061770-0	2002	Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha expression by 4-nonylphenol in macrophages.	4-nonylphenol	93-106	nitric oxide synthase 2, inducible	Mus musculus	15-46
11936222-7	2002	4-t-Octylphenol and 4-nonylphenol inhibited the binding of E2 to the ER of MCF-7 cells in a competitive ER binding assay.	4-nonylphenol	20-33	estrogen receptor 1	Homo sapiens	104-106
10746942-7	2000	As expected, the binding affinities for the estrogen receptor ranged from high to low, as reflected by Ki concentrations of 0.4 nM for 17-beta-estradiol and ethynyl estradiol, and 0.05-65 microM for 4-tert-octyphenol, 4-nonylphenol, and methoxychlor.	4-nonylphenol	218-231	estrogen receptor 1	Rattus norvegicus	44-61
11248424-0	2001	Suppression of CYP1A1 expression by 4-nonylphenol in murine Hepa-1c1c7 cells.	4-nonylphenol	36-49	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	15-21
11248424-1	2001	This study investigated the effects that 4-nonylphenol (NP) has on CYP1A1 expression in Hepa-1c1c7 cell cultures.	4-nonylphenol	41-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	67-73
11248424-1	2001	This study investigated the effects that 4-nonylphenol (NP) has on CYP1A1 expression in Hepa-1c1c7 cell cultures.	4-nonylphenol	56-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	67-73
11112451-1	2000	Much attention has focused on environmental estrogenic chemicals such as para-nonylphenol which disrupt various tissues via the estrogen receptor.	4-nonylphenol	73-89	estrogen receptor 1	Homo sapiens	128-145
11112451-9	2000	Our results suggest that para-nonylphenol suppressed 92 kDa gelatinase secretion via the estrogen receptor, however, para-nonylphenol interacts with the estrogen receptor in a manner distinct from estradiol.	4-nonylphenol	25-41	estrogen receptor 1	Homo sapiens	89-106
11112451-9	2000	Our results suggest that para-nonylphenol suppressed 92 kDa gelatinase secretion via the estrogen receptor, however, para-nonylphenol interacts with the estrogen receptor in a manner distinct from estradiol.	4-nonylphenol	117-133	estrogen receptor 1	Homo sapiens	153-170
10492896-7	1999	In Danio rerio oral application of 40 micrograms 4-nonylphenol/fish per day during a 3-week exposure period caused a major increase of serum vitellogenin.	4-nonylphenol	49-62	LOC100136735	Oncorhynchus mykiss	141-153
10406482-6	1999	In this study, 4-nonylphenol and 4-tertoctylphenol, two alkylphenols used as surfactants in many commercial products, and bisphenol A and O-hydroxybiphenyl, widely used in the plastics industry, were identified as potent hSHBG-ligands.	4-nonylphenol	15-28	sex hormone binding globulin	Homo sapiens	221-226
10492906-0	1999	Induction of hepatic estrogen receptor in juvenile Atlantic salmon in vivo by the environmental estrogen, 4-nonylphenol.	4-nonylphenol	106-119	estrogen receptor	Salmo salar	21-38
10492906-8	1999	Various studies have also shown that NP competitively inhibits the binding of 17 beta-estradiol (E2) to ER.	4-nonylphenol	37-39	estrogen receptor	Salmo salar	104-106
9827029-0	1998	Vitellogenin in Zoarces viviparus: purification, quantification by ELISA and induction by estradiol-17 beta and 4-nonylphenol.	4-nonylphenol	112-125	vitellogenin	Oryctolagus cuniculus	0-12
10197616-9	1999	Specifically, P450 3A4 was responsible for the formation of 3-hydroxy-1nitropyrene from 1-NP and the formation of trans-9,10-dihydro-9,10dihydroxy-4-nitropyrene, 9(10)-hydroxy-4-nitropyrene, and 4-aminopyrene from 4-NP.	4-nonylphenol	214-218	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	14-18
9827029-8	1998	A marked effect of exposure to ambient 4-nonylphenol was observed by significant dose-dependent increases in the level of plasma vitellogenin of the pregnant fish as well as of embryos exposed in vitro.	4-nonylphenol	39-52	vitellogenin	Oryctolagus cuniculus	129-141
34444624-5	2021	The resultant novel BRET-based on the ERalpha dimerization assay was used to identify the binding affinity of 17beta-estradiol (E2), 17alpha-estradiol, corticosterone, diethylhexyl phthalate, bisphenol A, and 4-nonylphenol with ERalpha by measuring the corresponding BRET signals.	4-nonylphenol	209-222	estrogen receptor 1	Homo sapiens	38-45
9189707-3	1997	Immunochemical analysis of plasma from Atlantic salmon (Salmo salar) exposed to 4-nonylphenol (NP) or to effluent from oil refinery treatment plant (ORTP), shows that NP and ORTP effluent induces Vtg and zona radiata proteins (Zrp) in a dose-dependent manner.	4-nonylphenol	80-93	vitellogenin	Salmo salar	196-199
8954930-5	1996	However, the estrogenic chemicals p-nonylphenol and 4-tert-octyphenol, and pentachlorophenol, effectively inhibited the activity of the hPR in yeast.	4-nonylphenol	34-47	haptoglobin-related protein	Homo sapiens	136-139
34553387-12	2022	Additionally, 4-NP downregulated beta-catenin expression in C3H/10T1/2 adipocytes.	4-nonylphenol	14-18	catenin (cadherin associated protein), beta 1	Mus musculus	33-45
34444624-5	2021	The resultant novel BRET-based on the ERalpha dimerization assay was used to identify the binding affinity of 17beta-estradiol (E2), 17alpha-estradiol, corticosterone, diethylhexyl phthalate, bisphenol A, and 4-nonylphenol with ERalpha by measuring the corresponding BRET signals.	4-nonylphenol	209-222	estrogen receptor 1	Homo sapiens	228-235
34084133-4	2021	Here, we found that 4-NP can result in male reproductive impairment and reduce androgen receptor (AR) protein levels in rat sertoli cells in vitro and in vivo.	4-nonylphenol	20-24	androgen receptor	Rattus norvegicus	79-96
34084133-4	2021	Here, we found that 4-NP can result in male reproductive impairment and reduce androgen receptor (AR) protein levels in rat sertoli cells in vitro and in vivo.	4-nonylphenol	20-24	androgen receptor	Rattus norvegicus	98-100
35190616-3	2022	Especially, six compounds, including 4f-h and 4n-p, exhibited cytotoxicity equal or superior to positive control PAC-1, the first procaspase-3 activating compound.	4-nonylphenol	46-50	caspase 3	Homo sapiens	130-142
35502944-2	2022	Previously, we reported that exposure to 17alpha-methyltestosterone, bisphenol A, or 4-nonylphenol induces changes in expression of gonadal soma-derived factor (gsdf) gene accompanied by disruption of gonadal differentiation in Japanese medaka (Oryzias latipes).	4-nonylphenol	85-98	gonadal somatic cell derived factor	Oryzias latipes	132-159
35502944-2	2022	Previously, we reported that exposure to 17alpha-methyltestosterone, bisphenol A, or 4-nonylphenol induces changes in expression of gonadal soma-derived factor (gsdf) gene accompanied by disruption of gonadal differentiation in Japanese medaka (Oryzias latipes).	4-nonylphenol	85-98	gonadal somatic cell derived factor	Oryzias latipes	161-165