PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32915407-5	2021	Notably, the level of lipocalin-2 (Lcn 2), a trigger factor of inflammation, was remarkably elevated in the plasma and lung tissues of KD rats; increased Lcn 2 levels following LCWE stimulation may result from polymorphonuclear neutrophils (PMNs).	lcwe	177-181	lipocalin 2	Rattus norvegicus	22-33
34026693-5	2021	Compared with control WT mice, LCWE-injected miR-223-deficient mice (miR223 -/y ) developed more severe coronary arteritis and aortitis, as well as more pronounced abdominal aorta aneurysms and dilations.	lcwe	31-35	microRNA 223	Mus musculus	45-52
34026693-5	2021	Compared with control WT mice, LCWE-injected miR-223-deficient mice (miR223 -/y ) developed more severe coronary arteritis and aortitis, as well as more pronounced abdominal aorta aneurysms and dilations.	lcwe	31-35	microRNA 223	Mus musculus	69-75
33897686-9	2021	Results: STAT3 was highly expressed and phosphorylated in cardiac tissue of LCWE-injected mice, and reduced following anakinra treatment.	lcwe	76-80	signal transducer and activator of transcription 3	Mus musculus	9-14
33897686-11	2021	IL-6 serum levels were enhanced in LCWE-injected mice and normalized by anakinra.	lcwe	35-39	interleukin 6	Mus musculus	0-4
32915407-5	2021	Notably, the level of lipocalin-2 (Lcn 2), a trigger factor of inflammation, was remarkably elevated in the plasma and lung tissues of KD rats; increased Lcn 2 levels following LCWE stimulation may result from polymorphonuclear neutrophils (PMNs).	lcwe	177-181	lipocalin 2	Rattus norvegicus	35-40
32915407-5	2021	Notably, the level of lipocalin-2 (Lcn 2), a trigger factor of inflammation, was remarkably elevated in the plasma and lung tissues of KD rats; increased Lcn 2 levels following LCWE stimulation may result from polymorphonuclear neutrophils (PMNs).	lcwe	177-181	lipocalin 2	Rattus norvegicus	154-159
31099056-7	2019	Both MRI and echocardiographic studies on LCWE-injected KD mice demonstrated that IL-1Ra pretreatment results in an improved ejection fraction and a normalized left ventricular function.	lcwe	42-46	interleukin 1 receptor antagonist	Mus musculus	82-88
31758701-6	2020	Furthermore, serum nerve growth factor (NGF) was significantly elevated in LCWE-injected mice, similar to children with KD vasculitis, associated with increased neural remodeling of the myocardium.	lcwe	75-79	nerve growth factor	Mus musculus	19-38
31758701-6	2020	Furthermore, serum nerve growth factor (NGF) was significantly elevated in LCWE-injected mice, similar to children with KD vasculitis, associated with increased neural remodeling of the myocardium.	lcwe	75-79	nerve growth factor	Mus musculus	40-43
31758701-8	2020	Thus, similar to clinical KD, the LCWE-induced KD vasculitis mouse model also exhibits electrophysiological abnormalities and cardiac neuronal remodeling, and these changes can be prevented by blocking IL-1 signaling.	lcwe	34-38	interleukin 1 complex	Mus musculus	202-206
27696768-9	2017	CONCLUSION: The LCWE-induced murine model of KD vasculitis mimics many histologic features of the disease in humans, such as the presence of CD8+ T cells and LMP in coronary artery lesions as well as epicardial coronary arteritis.	lcwe	16-20	CD8a molecule	Homo sapiens	141-144
25450976-4	2015	Endothelial dysfunction associated with increased vascular cell adhesion protein 1 (VCAM-1) expression and endothelial-leukocyte adhesion was observed during coronary arteritis in mice treated with LCWE.	lcwe	198-202	vascular cell adhesion molecule 1	Mus musculus	50-82
25450976-4	2015	Endothelial dysfunction associated with increased vascular cell adhesion protein 1 (VCAM-1) expression and endothelial-leukocyte adhesion was observed during coronary arteritis in mice treated with LCWE.	lcwe	198-202	vascular cell adhesion molecule 1	Mus musculus	84-90
25450976-10	2015	In vivo, treatment of mice with cathepsin B inhibitor also abolished LCWE-induced inflammasome activation in coronary arterial endothelium.	lcwe	69-73	cathepsin B	Mus musculus	32-43
22633994-4	2013	We found that LCWE induced in vitro macrophage activation with increased production of IL-6, TNF-alpha, and MCP-1, concomitantly with Syk activation, and dectin-1 and TLR2 enhancement.	lcwe	14-18	interleukin 6	Mus musculus	87-91
22633994-4	2013	We found that LCWE induced in vitro macrophage activation with increased production of IL-6, TNF-alpha, and MCP-1, concomitantly with Syk activation, and dectin-1 and TLR2 enhancement.	lcwe	14-18	tumor necrosis factor	Mus musculus	93-102
22633994-4	2013	We found that LCWE induced in vitro macrophage activation with increased production of IL-6, TNF-alpha, and MCP-1, concomitantly with Syk activation, and dectin-1 and TLR2 enhancement.	lcwe	14-18	mast cell protease 1	Mus musculus	108-113
22633994-4	2013	We found that LCWE induced in vitro macrophage activation with increased production of IL-6, TNF-alpha, and MCP-1, concomitantly with Syk activation, and dectin-1 and TLR2 enhancement.	lcwe	14-18	spleen tyrosine kinase	Mus musculus	134-137
22633994-4	2013	We found that LCWE induced in vitro macrophage activation with increased production of IL-6, TNF-alpha, and MCP-1, concomitantly with Syk activation, and dectin-1 and TLR2 enhancement.	lcwe	14-18	C-type lectin domain family 7, member a	Mus musculus	154-162
22361326-9	2012	Injection of recombinant IL-1beta into caspase-1-deficient mice restored the ability of LCWE to cause coronary lesions in response to LCWE.	lcwe	88-92	interleukin 1 beta	Mus musculus	25-33
22361326-9	2012	Injection of recombinant IL-1beta into caspase-1-deficient mice restored the ability of LCWE to cause coronary lesions in response to LCWE.	lcwe	88-92	caspase 1	Mus musculus	39-48