PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 9824251-3 1998 Exposure to aniline is toxic because it produces methemoglobin. aniline 12-19 hemoglobin subunit gamma 2 Homo sapiens 49-62 9824251-4 1998 In humans, blood methemoglobin levels are often measured as an index of exposure to aniline. aniline 84-91 hemoglobin subunit gamma 2 Homo sapiens 17-30 9724514-2 1998 The miscoding properties of these arylamine adducts were established by analyzing fully extended products of primer extension reactions catalyzed by mammalian DNA polymerases alpha, beta, and delta. aniline 34-43 DNA polymerase alpha 1, catalytic subunit Homo sapiens 159-197 9760285-13 1998 The observed TPO-catalyzed oxidative demethylation of LMG to a primary arylamine also suggests a genotoxic mechanism for tumor formation is possible. aniline 71-80 thyroid peroxidase Homo sapiens 13-16 9784004-2 1998 Ciprofibrates (racemate and both enantiomers) bind to oxidized cytochrome P-450 in rat liver microsomes according type II like aniline or most probably as inversed type I, but less pronounced and with a general shift to the left. aniline 127-134 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 63-79 9705891-9 1998 The CYP2E1-specific inhibitors, diethyldithiocarbamate (DDC) and aniline, significantly reduced 6-OH CZX production by 80 and 35%, respectively. aniline 65-72 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 4-10 9610789-5 1998 The p53 mutation spectrum of these cyclophosphamide-associated bladder cancers differed significantly from patterns reported for sporadic (P = 0.020), smoking-related (0.043), and schistosomiasis-linked (P = 0.002) tumors but not arylamine-associated neoplasms (P = 0.860). aniline 230-239 tumor protein p53 Homo sapiens 4-7 9617978-5 1998 Moreover, CYP1A2 also contributes to metabolism of 17beta-estradiol and metabolic activation of environmental procarcinogens (e.g., arylamines in cigarette smoke). aniline 132-142 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 10-16 9608747-1 1998 N-Acetyltransferase (NAT), responsible for bioactivation and detoxification of arylamines, has been demonstrated to be widely distributed in many organisms ranging from humans to microorganisms. aniline 79-89 bromodomain containing 2 Homo sapiens 0-19 9608747-1 1998 N-Acetyltransferase (NAT), responsible for bioactivation and detoxification of arylamines, has been demonstrated to be widely distributed in many organisms ranging from humans to microorganisms. aniline 79-89 bromodomain containing 2 Homo sapiens 21-24 9608747-13 1998 These findings are very helpful for further investigating the role of arylamine NAT in this bacterial species. aniline 70-79 bromodomain containing 2 Homo sapiens 80-83 9605428-4 1998 CP-24879 (p-isopentoxyaniline), an aniline derivative, was identified as a mixed delta5/delta6 desaturase inhibitor during the screening of chemical and natural product libraries. aniline 22-29 fatty acid desaturase 1 Mus musculus 81-105 9875424-1 1998 Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. aniline 8-15 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 116-119 9875424-1 1998 Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. aniline 8-15 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 165-168 9569604-2 1998 The present report describes the immobilization of commercially available horseradish peroxidase on to zirconia-coated arylamine glass beads through diazotization and a new method for the discrete assay of urinary oxalate using both immobilized oxalate oxidase and peroxidase. aniline 119-128 prx7 Hordeum vulgare 86-96 9472690-5 1998 NAT2, a phase II detoxification enzyme, has been implicated in procarcinogen activation, namely from food contained arylamines, cigarette smoking, as well as environmental amines of various types. aniline 116-126 N-acetyltransferase 2 Homo sapiens 0-4 9577349-1 1998 BACKGROUND: Arylamine N-acetyltransferases in humans (NAT1 and NAT2) catalyse the acetylation of arylamines including food derived heterocyclic arylamine carcinogens. aniline 97-107 N-acetyltransferase 1 Homo sapiens 54-58 9577349-1 1998 BACKGROUND: Arylamine N-acetyltransferases in humans (NAT1 and NAT2) catalyse the acetylation of arylamines including food derived heterocyclic arylamine carcinogens. aniline 97-107 N-acetyltransferase 2 Homo sapiens 63-67 9511183-1 1998 Human N-acetyltransferase type 1 (NAT1) catalyses the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. aniline 85-94 N-acetyltransferase 1 Homo sapiens 6-32 9511183-1 1998 Human N-acetyltransferase type 1 (NAT1) catalyses the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. aniline 85-94 N-acetyltransferase 1 Homo sapiens 34-38 10592822-10 1997 This report is the first demonstration of acetyl CoA: arylamine NAT activity in S. aureus. aniline 54-63 AT695_RS04655 Staphylococcus aureus 64-67 9512925-8 1997 Furthermore, increased hydrogen peroxide formation, e.g. as a result of oxidative stress, would also be expected to enhance the metabolic activation of carcinogenic arylamines via the peroxygenase function of CYP1A2. aniline 165-175 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 209-215 9321764-1 1997 Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders, including lupus erythematosus and arylamine induced cancers. aniline 6-15 bromodomain containing 2 Homo sapiens 37-40 9321764-1 1997 Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders, including lupus erythematosus and arylamine induced cancers. aniline 6-15 N-acetyltransferase 1 Homo sapiens 88-92 9321764-1 1997 Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders, including lupus erythematosus and arylamine induced cancers. aniline 6-15 N-acetyltransferase 2 Homo sapiens 97-101 9321764-1 1997 Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders, including lupus erythematosus and arylamine induced cancers. aniline 6-15 N-acetyltransferase 2 Homo sapiens 149-153 18966880-0 1997 Immobilization of uricase to gas diffusion carbon felt by electropolymerization of aniline and its application as an enzyme reactor for uric acid sensor. aniline 83-90 urate oxidase (pseudogene) Homo sapiens 18-25 18966880-1 1997 Electropolymerizations of aniline and pyrrole solutions containing uricase at a neutral pH was performed to immobilize the enzyme on the surface of the gas diffusion carbon felt, and a selective uric acid sensor was fabricated by combining immobilized enzyme carbon felt and an oxygen electrode with oxygen gas permeable membrane. aniline 26-33 urate oxidase (pseudogene) Homo sapiens 67-74 9572394-1 1998 Multiple variant alleles of the human arylamine N-acetyltransferase genes, NAT1* and NAT2*, alter the capacity of individuals to metabolize arylamines by N-acetylation. aniline 140-150 N-acetyltransferase 1 Homo sapiens 75-79 9572394-1 1998 Multiple variant alleles of the human arylamine N-acetyltransferase genes, NAT1* and NAT2*, alter the capacity of individuals to metabolize arylamines by N-acetylation. aniline 140-150 N-acetyltransferase 2 Homo sapiens 85-89 9449220-10 1997 This is a first report suggesting that oral vitamin C may be involved in modifying the mutagenicity/carcinogenicity of ingested arylamines through enhancing the NAT activity of human enteric bacteria. aniline 128-138 bromodomain containing 2 Homo sapiens 161-164 9281311-5 1997 Upon reconstitution with rat NADPH-cytochrome P450 reductase and phospholipid, the Xenopus P450 catalyzed aniline hydroxylation and N-nitrosodimethylamine N-demethylation. aniline 106-113 cytochrome p450 oxidoreductase Rattus norvegicus 29-60 11669958-2 1997 The complexes Os(Por)(HNAr)(2) are prepared from the reactions of Os(Por)(N(2))(THF) with arylamines in aerobic tetrahydrofuran. aniline 90-100 cytochrome p450 oxidoreductase Homo sapiens 17-20 11669958-2 1997 The complexes Os(Por)(HNAr)(2) are prepared from the reactions of Os(Por)(N(2))(THF) with arylamines in aerobic tetrahydrofuran. aniline 90-100 cytochrome p450 oxidoreductase Homo sapiens 69-72 9296352-1 1997 The purpose of this study was to determine the molecular basis in the dog for an unusual and absolute deficiency in the activity of cytosolic N-acetyltransferase (NAT), an enzyme important for the metabolism of arylamine and hydrazine compounds. aniline 211-220 bromodomain containing 2 Homo sapiens 163-166 9152602-1 1997 Human cytochrome P450 (P450) 1B1 (CYP1B1) has recently been shown to be an important enzyme in the activation of diverse procarcinogens such as arylarenes, nitroarenes, and arylamines to reactive metabolites that cause DNA damage in the cells. aniline 173-183 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 6-32 9173883-1 1997 The arylamine N-acetyltransferases (NATs) NAT1 and NAT2 are responsible for the biotransformation of many arylamine and hydroxylamine xenobiotics. aniline 4-13 N-acetyltransferase 1 Homo sapiens 42-46 9173883-1 1997 The arylamine N-acetyltransferases (NATs) NAT1 and NAT2 are responsible for the biotransformation of many arylamine and hydroxylamine xenobiotics. aniline 4-13 N-acetyltransferase 2 Homo sapiens 51-55 9173883-6 1997 NAT1 or NAT2 singly substituted at Arg9 or Arg64 with Ala, Met, Gln or Lys exhibited unaltered Km values for arylamine acceptor substrates, but a marked loss of activity and stability. aniline 109-118 N-acetyltransferase 1 Homo sapiens 0-4 9173883-6 1997 NAT1 or NAT2 singly substituted at Arg9 or Arg64 with Ala, Met, Gln or Lys exhibited unaltered Km values for arylamine acceptor substrates, but a marked loss of activity and stability. aniline 109-118 N-acetyltransferase 2 Homo sapiens 8-12 9173883-7 1997 Finally, double replacement of Arg9/Arg64 with lysine in NAT1 altered the Km for arylamine substrates (decreased by 8-14-fold) and for acetyl-CoA (elevated 5-fold), and modified the pH-dependence of activity. aniline 81-90 N-acetyltransferase 1 Homo sapiens 57-61 9202739-1 1997 Conjugation of primary amino and hydroxylamino groups with acetate, catalyzed by acetyl CoA-dependent arylamine acetyltransferase (NAT) enzymes, may play an important role in the intricate series of metabolic pathways that produce or prevent toxicity following exposure to homo- and heterocyclic arylamine and hydrazine xenobiotics. aniline 102-111 bromodomain containing 2 Homo sapiens 131-134 9202739-9 1997 Because of the important toxicologic consequences of allelic variation in NAT1 and NAT2 function for the metabolic activation of arylamine and heterocyclic amine procarcinogens, further studies are needed to improve our understanding of the extent of NAT allelic variation, to determine the functional capacity of each variant gene product, and to develop accurate methods of detecting them in population and epidemiological studies. aniline 129-138 N-acetyltransferase 1 Homo sapiens 74-78 9202739-9 1997 Because of the important toxicologic consequences of allelic variation in NAT1 and NAT2 function for the metabolic activation of arylamine and heterocyclic amine procarcinogens, further studies are needed to improve our understanding of the extent of NAT allelic variation, to determine the functional capacity of each variant gene product, and to develop accurate methods of detecting them in population and epidemiological studies. aniline 129-138 N-acetyltransferase 2 Homo sapiens 83-87 9202739-9 1997 Because of the important toxicologic consequences of allelic variation in NAT1 and NAT2 function for the metabolic activation of arylamine and heterocyclic amine procarcinogens, further studies are needed to improve our understanding of the extent of NAT allelic variation, to determine the functional capacity of each variant gene product, and to develop accurate methods of detecting them in population and epidemiological studies. aniline 129-138 bromodomain containing 2 Homo sapiens 74-77 9202747-4 1997 Expression of rat acetyltransferases responsible for acetylation of the nitrogen and the oxygen of arylamine derivatives (i.e., acetyltransferases 1 and 2) in bacterial cells has now permitted experiments which demonstrate that these enzymes exhibit good affinities for and N-acetylation of the endogenous arylalkylamines derived from tryptophan, i.e., tryptamine, 5-hydroxytryptamine (serotonin) and 5-methoxytryptamine, the immediate metabolic precursor of melatonin. aniline 99-108 N-acetyltransferase 8 Rattus norvegicus 128-154 9152602-1 1997 Human cytochrome P450 (P450) 1B1 (CYP1B1) has recently been shown to be an important enzyme in the activation of diverse procarcinogens such as arylarenes, nitroarenes, and arylamines to reactive metabolites that cause DNA damage in the cells. aniline 173-183 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-40 9063569-2 1997 Aniline hydroxylation and N-nitrosodimethylamine demethylation, which are known to be catalyzed by CYP2E1, in liver microsomes were induced and suppressed by the treatment with isoniazid and the fasting, respectively. aniline 0-7 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 99-105 8960058-1 1997 Human arylamine N-acetyltransferase 1 (NAT1) has 290 amino acids and acetylates arylamines from acetyl coenzyme A. aniline 80-90 N-acetyltransferase 1 Homo sapiens 6-37 9023313-12 1997 Testosterone 6beta-hydroxylation (mediated by CYP3A4), 7-ethylresorufin O-deethylation (CYP1A2) and tolbutamide methyl hydroxylation (CYP2C9/10), but not aniline 4-hydroxylation (CYP2E1), were inhibited effectively by parathion. aniline 154-161 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 134-140 8960058-1 1997 Human arylamine N-acetyltransferase 1 (NAT1) has 290 amino acids and acetylates arylamines from acetyl coenzyme A. aniline 80-90 N-acetyltransferase 1 Homo sapiens 39-43 9156695-1 1996 The hepatic N-acetyltransferase enzyme encoded by the NAT2* gene locus is responsible for the human polymorphic acetylation of numerous arylamine or hydrazine-containing drugs and xenobiotics including AIDS-related therapeutic agents such as isoniazid and sulphonamides. aniline 136-145 N-acetyltransferase 2 Homo sapiens 54-58 9131254-7 1997 The acetylation polymorphism concerns the metabolism of a variety of arylamine and hydrazine drugs, as well as carcinogens by the cytosolic N-acetyltransferase NAT2. aniline 69-78 N-acetyltransferase 2 Homo sapiens 160-164 8781504-3 1996 Aniline reduced the activity of alcohol dehydrogenase in a noncompetitive manner, but had no effect on aldehyde dehydrogenase activity nor on reducing-equivalent transfer between the cytoplasm and mitochondria. aniline 0-7 aldo-keto reductase family 1 member A1 Rattus norvegicus 32-53 8781504-4 1996 The inhibition of alcohol dehydrogenase by aniline was associated with a decrease in the inhibitory effects of ethanol on glycolysis. aniline 43-50 aldo-keto reductase family 1 member A1 Rattus norvegicus 18-39 8807666-0 1996 NAT2*12A (803A-->G) codes for rapid arylamine n-acetylation in humans. aniline 39-48 N-acetyltransferase 2 Homo sapiens 0-4 8627536-7 1996 Cytochrome P-450 reactions attributed to P-450s other than CYP2D, such as aniline p-hydroxylation, the high Km system of MDMA demethylation and the N-demethylation of methamphetamine, benzphetamine, aminopyrine and erythromycin, all appeared to be minimally affected. aniline 74-81 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 8973193-4 1996 Comparative studies of the spectral interaction and inhibitory effects of twelve compounds related to 1 with CYP 2C9 showed that the aniline function of 1 is responsible for the formation of the iron-nitrogen bond of the 429 nm-absorbing complex and is necessary for the inhibitory effects of 1. aniline 133-140 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 109-116 8975762-5 1996 Induction of CYP2E1 was observed in both sexes, evidenced as increased activities of aniline and p-nitrophenol hydroxylases and increased CYP2E1 protein amount determined by immunoblot assay. aniline 85-92 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 13-19 8694855-0 1996 Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. aniline 84-91 cytochrome b5 type A Homo sapiens 17-30 8694855-0 1996 Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. aniline 84-91 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 135-154 8854220-5 1996 Due to the addition of isoflurane, the Vmax values for aniline hydroxylation evidently increased except in high isoflurane concentration (3.33 mM) and for aminopyrine N-demethylation the value was significantly low only in the presence of a high isoflurane concentration, whereas the K(m) values significantly decreased in aniline hydroxylation and increased in aminopyrine N-demethylation, and isoflurane also accelerated the rate of cytochrome P-450 reduction by NADPH. aniline 55-62 cytochrome P450 3A14 Cavia porcellus 435-451 8854220-6 1996 These results reflect the inhibition of aminopyrine N-demethylation and activation of aniline hydroxylation in the presence of isoflurane as a consequence of isoflurane-accelerated cytochrome P-450 reduction by NADPH and/or drug-enzyme binding properties, and may have implications on the metabolism of perioperatively administered drugs during isoflurane anaesthesia. aniline 86-93 cytochrome P450 3A14 Cavia porcellus 181-197 8819299-4 1996 Coumarin, 7-ethoxyresorufin, 7-benzyloxyresorufin, tolbutamide, aniline and diazepam were form-selective substrates towards CYP2A6, the CYP1A subfamily, CYP2B6, the CYP2C subfamily, CYP2E1 and the CYP3A subfamily respectively. aniline 64-71 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 124-130 8819299-4 1996 Coumarin, 7-ethoxyresorufin, 7-benzyloxyresorufin, tolbutamide, aniline and diazepam were form-selective substrates towards CYP2A6, the CYP1A subfamily, CYP2B6, the CYP2C subfamily, CYP2E1 and the CYP3A subfamily respectively. aniline 64-71 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 153-159 8819299-4 1996 Coumarin, 7-ethoxyresorufin, 7-benzyloxyresorufin, tolbutamide, aniline and diazepam were form-selective substrates towards CYP2A6, the CYP1A subfamily, CYP2B6, the CYP2C subfamily, CYP2E1 and the CYP3A subfamily respectively. aniline 64-71 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 182-188 8523409-2 1995 A series of 1-phenyl-3-(aminomethyl)pyrroles were prepared in two steps from aniline and their affinities for D2, D3, and D4 dopamine receptor subtypes determined. aniline 77-84 dopamine receptor D4 Homo sapiens 122-142 8542583-0 1996 p53 mutations in bladder tumors from arylamine-exposed workers. aniline 37-46 tumor protein p53 Homo sapiens 0-3 8542583-1 1996 In this study we compared the frequency and pattern of p53 mutations in 34 bladder tumors from people with high-level occupational exposure to arylamines to those in 30 bladder tumors from people without such exposure. aniline 143-153 tumor protein p53 Homo sapiens 55-58 8643688-2 1996 CYP1A2 substrates include aflatoxin B1, acetaminophen, and a variety of environmental arylamines. aniline 86-96 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 0-6 8845861-12 1996 NAT2 16A exhibited 500-to 1000-fold lower maximum velocities compared to NAT2 15 for N-acetylation of all arylamine and hydrazine substrates tested. aniline 106-115 arylamine N-acetyltransferase 2 Mesocricetus auratus 0-4 8845861-12 1996 NAT2 16A exhibited 500-to 1000-fold lower maximum velocities compared to NAT2 15 for N-acetylation of all arylamine and hydrazine substrates tested. aniline 106-115 arylamine N-acetyltransferase 2 Mesocricetus auratus 73-80 8634658-1 1995 Cigarette smoking is the major cause of bladder cancer in men in the United States, and the arylamines contained in cigarettes smoke, including 4-amino-biphenyl (4-ABP), are believed to play an important role in the induction of bladder cancer among smokers. aniline 92-102 amine oxidase copper containing 1 Homo sapiens 164-167 7782560-9 1995 3-Chloroaniline also was the only aniline compound to increase plasma ALT/GPT activity at 48 h. In the in vitro experiments, the ability of an aniline (10(-5) - 10(-3) M) to decrease organic ion accumulation in renal cortical slices from untreated rats was examined. aniline 8-15 glutamic--pyruvic transaminase Rattus norvegicus 74-77 7669073-1 1995 Arylamine N-acetyltransferase (NAT2) catalyses the N-acetylation of primary arylamine and hydrazine drugs and chemicals. aniline 76-85 N-acetyltransferase 2 Homo sapiens 31-35 7627960-1 1995 Human polymorphic N-acetyltransferase (NAT2) catalyzes the N-acetylation of arylamine carcinogens and the metabolic activation of N-hydroxyarylamine and N-hydroxyarylamide carcinogens by O- and N,O-acetylation, respectively. aniline 76-85 N-acetyltransferase 2 Homo sapiens 39-43 7627960-2 1995 Rapid and slow acetylator phenotype is regulated at the NAT2 locus, and each has been associated with differential risk to certain cancers relating to carcinogenic arylamine exposures. aniline 164-173 N-acetyltransferase 2 Homo sapiens 56-60 7627960-3 1995 We examined arylamine N-acetylation, N-hydroxyarylamine O-acetylation, and N-hydroxyarylamide N,O-acetylation catalytic activities of 16 different recombinant human NAT2 alleles expressed in an Escherichia coli JM105 expression system. aniline 12-21 N-acetyltransferase 2 Homo sapiens 165-169 7483672-10 1995 Sulphamethazine and other arylamines containing electron-withdrawing substituents inhibit TPO compound I-mediated reactions by reversible, mixed-type inhibition. aniline 26-36 thyroid peroxidase Homo sapiens 90-93 7616363-1 1995 The effects of pH and aniline trapping on the partitioning of the A-21 cyclic anhydride intermediate of human insulin into deamidated insulin and covalent dimer were investigated at low pH and 35 degrees C. Characterization of the covalent dimer was achieved by proteolytic cleavage and electrospray mass spectrometry and indicated that the deamidated A-21 asparagine of one insulin molecule and the B-1 phenylalanine residue of another are involved. aniline 22-29 insulin Homo sapiens 110-117 7616363-2 1995 Anhydride trapping with aniline at pH 4.0 provided evidence that the rate-limiting generation of a cyclic anhydride intermediate is involved in the formation of both deamidated and dimeric insulin. aniline 24-31 insulin Homo sapiens 189-196 7616363-3 1995 In the presence of aniline at pH 4.0 insulin formed two anilide products, A-21 N delta 2-phenylasparagine and N delta 2-phenylasparagine and N gamma 2-phenylaspartic acid human insulin at the expense of both desamido A-21 and covalent dimer formation, consistent with the formation of a common intermediate. aniline 19-26 insulin Homo sapiens 37-44 7616363-3 1995 In the presence of aniline at pH 4.0 insulin formed two anilide products, A-21 N delta 2-phenylasparagine and N delta 2-phenylasparagine and N gamma 2-phenylaspartic acid human insulin at the expense of both desamido A-21 and covalent dimer formation, consistent with the formation of a common intermediate. aniline 19-26 insulin Homo sapiens 177-184 7757072-4 1995 NAT is an enzymic activity involved in the metabolism of arylamines, and its "classical" polymorphism is due to multiple alleles at the NAT2 locus. aniline 57-67 bromodomain containing 2 Homo sapiens 0-3 7757072-4 1995 NAT is an enzymic activity involved in the metabolism of arylamines, and its "classical" polymorphism is due to multiple alleles at the NAT2 locus. aniline 57-67 N-acetyltransferase 2 Homo sapiens 136-140 7556113-1 1995 p-Aminophenol (PAP), a metabolite of aniline and acetaminophen, has been reported to be mutagenic in the L5178Y mouse lymphoma assay, but not in the CHO/HGPRT assay. aniline 37-44 mitochondrial ribosomal protein S30 Mus musculus 0-13 7749659-5 1995 Total amount of cytochrome P450 was reduced, as was its activity, assessed by the rates of hydroxylation of aniline and of demethylation of aminopyrine. aniline 108-115 cytochrome P-450 Oryctolagus cuniculus 16-31 7556113-1 1995 p-Aminophenol (PAP), a metabolite of aniline and acetaminophen, has been reported to be mutagenic in the L5178Y mouse lymphoma assay, but not in the CHO/HGPRT assay. aniline 37-44 mitochondrial ribosomal protein S30 Mus musculus 15-18 7588993-3 1995 Induction of CYP2E1 was shown by aniline or p-nitro-phenol hydroxylation as a result of ipriflavone treatment. aniline 33-40 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 13-19 7588993-4 1995 Aniline hydroxylation activity of CYP2E1 was induced by theophylline + ipriflavone (100 mg/kg) coadministration as well. aniline 0-7 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 34-40 7480023-0 1995 Metabolic activation of carcinogenic arylamines by rapid acetylator, slow acetylator, and chimeric recombinant Syrian hamster NAT2 allozymes. aniline 37-47 arylamine N-acetyltransferase 2 Mesocricetus auratus 126-130 8001235-8 1994 These results suggest that susceptibility to arylamine-induced bladder cancer might be influenced by both hepatic and bladder NAT and that the NAT genotype might be a useful biomarker for screening high risk individuals for bladder cancer resulting from exposure to arylamines. aniline 45-54 bromodomain containing 2 Homo sapiens 126-129 7915226-8 1994 Both the NAT2(191) and NAT2(341/803) mutant alleles expressed functional N-acetyltransferases capable of catalyzing both arylamine N-acetylation and the metabolic activation (via O-acetylation) of N-hydroxy-2-aminofluorene. aniline 121-130 N-acetyltransferase 2 Homo sapiens 9-13 7841336-7 1994 Additional results of the present study demonstrate that the apparent Michaelis constant Kms of the NADPH/oxygen-supported 4-hydroxylation of the anilines decreases with increasing hydrophobicity of the aniline derivatives. aniline 146-153 2,4-dienoyl-CoA reductase 1 Homo sapiens 100-105 8063807-2 1994 Microsomal arylacetamide deacetylase (DAC) competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens in many species and tissues. aniline 86-95 arylacetamide deacetylase Homo sapiens 11-36 8063807-2 1994 Microsomal arylacetamide deacetylase (DAC) competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens in many species and tissues. aniline 86-95 arylacetamide deacetylase Homo sapiens 38-41 8063807-3 1994 Activity determination and immunoblot analysis of DAC in human target tissues for arylamine carcinogens revealed that in extrahepatic tissues, additional enzymes are responsible for any deacetylation activity, whereas a single enzyme predominantly catalyzes this hydrolytic reaction in liver. aniline 82-91 arylacetamide deacetylase Homo sapiens 50-53 8055632-9 1994 The results suggest marked differences in substrate specificity of different UGT isozymes for arylamines and their N-hyroxy derivatives. aniline 94-104 UDP-galactose translocator Cricetulus griseus 77-80 8075152-5 1994 (ii) Cytochrome P-450 2E1-dependent activities (e.g., N,N-dimethylnitrosamine demethylation and aniline hydroxylation) were induced after treatment with ethylbenzene for one day; however, after 3 days of ethylbenzene treatment these activities returned to control levels. aniline 96-103 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 5-25 8035095-6 1994 In the current study we characterized the activity of human placental NAT and deacetylase toward the carcinogenic arylamine, 2-aminofluorene (AF) and its acetylated metabolite, 2-acetylaminofluorene (AAF). aniline 114-123 bromodomain containing 2 Homo sapiens 70-73 7915226-8 1994 Both the NAT2(191) and NAT2(341/803) mutant alleles expressed functional N-acetyltransferases capable of catalyzing both arylamine N-acetylation and the metabolic activation (via O-acetylation) of N-hydroxy-2-aminofluorene. aniline 121-130 N-acetyltransferase 2 Homo sapiens 23-27 8081359-1 1994 Human polymorphic N-acetyltransferase (NAT2) catalyzes the N-acetylation of arylamine drugs and carcinogens. aniline 76-85 N-acetyltransferase 2 Homo sapiens 39-43 8182542-4 1994 Arylamine N-acetyltransferase (NAT) catalyzes the acetyl CoA-dependent N-acetylation of primary arylamine and hydrazine substrates such as sulfamethazine, isoniazid, p-aminobenzoic acid as well as arylamine carcinogens such as 2-aminofluorene and benzidine. aniline 96-105 bromodomain containing 2 Homo sapiens 31-34 8182542-4 1994 Arylamine N-acetyltransferase (NAT) catalyzes the acetyl CoA-dependent N-acetylation of primary arylamine and hydrazine substrates such as sulfamethazine, isoniazid, p-aminobenzoic acid as well as arylamine carcinogens such as 2-aminofluorene and benzidine. aniline 197-206 bromodomain containing 2 Homo sapiens 31-34 8199304-7 1994 The aniline derivatives containing electron-donating substituents (e.g., p-CH3, p-OEt, p-Cl) were converted by LPO to colored products characteristic of one-electron oxidation. aniline 4-11 lactoperoxidase Homo sapiens 111-114 7937515-4 1994 Insulin in the presence of aniline at low pH formed two anilide products, A-21 N delta 2-phenyl asparagine and N delta 2-phenyl aspartic acid human insulin, at the expense of desamido A-21 formation, consistent with the partitioning of a common intermediate. aniline 27-34 insulin Homo sapiens 148-155 8291051-9 1994 These results show a specific and significant role for NAT2 acetylator genotype in formation of arylamine-hemoglobin adducts, which may reflect the relationship between acetylator genotype and the incidence of different cancers from arylamine exposures. aniline 96-105 arylamine N-acetyltransferase 2 Mesocricetus auratus 55-59 8199304-3 1994 SMZ and other primary arylamines inhibited iodination reactions catalyzed by thyroid peroxidase (TPO) and the closely related lactoperoxidase (LPO). aniline 22-32 thyroid peroxidase Homo sapiens 97-100 8199304-3 1994 SMZ and other primary arylamines inhibited iodination reactions catalyzed by thyroid peroxidase (TPO) and the closely related lactoperoxidase (LPO). aniline 22-32 lactoperoxidase Homo sapiens 126-141 8199304-3 1994 SMZ and other primary arylamines inhibited iodination reactions catalyzed by thyroid peroxidase (TPO) and the closely related lactoperoxidase (LPO). aniline 22-32 lactoperoxidase Homo sapiens 143-146 8199304-4 1994 Inhibition of LPO-catalyzed triiodide ion formation by SMZ and other primary arylamines was complex as both apparent Km and Vmax values were affected, but consistent with a rapid equilibrium binding mechanism. aniline 77-87 lactoperoxidase Homo sapiens 14-17 8312255-6 1994 The experimental results suggest that the AF- and ABP-modified duplexes adopt essentially identical major conformations, with each arylamine moiety being positioned in the major groove of a slightly disturbed B-type DNA duplex. aniline 131-140 amine oxidase, copper-containing 1 Mus musculus 50-53 8296319-7 1994 The similarities of P450- and Hb-mediated aniline hydroxylation using stable isotopes preclude their use as in vivo probes. aniline 42-49 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 20-32 7920698-5 1994 These results suggest that significant variation in the acetylation of arylamine substrates susceptible to the classical acetylator polymorphism is attributable to variation in NAT1 activity in the slow acetylator phenotype. aniline 71-80 N-acetyltransferase 1 Homo sapiens 177-181 7937515-4 1994 Insulin in the presence of aniline at low pH formed two anilide products, A-21 N delta 2-phenyl asparagine and N delta 2-phenyl aspartic acid human insulin, at the expense of desamido A-21 formation, consistent with the partitioning of a common intermediate. aniline 27-34 insulin Homo sapiens 0-7 8291051-9 1994 These results show a specific and significant role for NAT2 acetylator genotype in formation of arylamine-hemoglobin adducts, which may reflect the relationship between acetylator genotype and the incidence of different cancers from arylamine exposures. aniline 233-242 arylamine N-acetyltransferase 2 Mesocricetus auratus 55-59 8291057-13 1994 Both arylamine N-acetylation and N-hydroxyarylamine O-acetylation were clearly acetylator genotype-dependent when catalyzed by NAT2, and both were clearly acetylator genotype-independent when catalyzed by NAT1. aniline 5-14 arylamine N-acetyltransferase 2 Mesocricetus auratus 127-131 8291057-13 1994 Both arylamine N-acetylation and N-hydroxyarylamine O-acetylation were clearly acetylator genotype-dependent when catalyzed by NAT2, and both were clearly acetylator genotype-independent when catalyzed by NAT1. aniline 5-14 arylamine N-acetyltransferase 1 Mesocricetus auratus 205-209 8291057-14 1994 NAT2/NAT1 activity ratios varied with the particular arylamine substrate acetylated. aniline 53-62 arylamine N-acetyltransferase 2 Mesocricetus auratus 0-4 8291057-14 1994 NAT2/NAT1 activity ratios varied with the particular arylamine substrate acetylated. aniline 53-62 arylamine N-acetyltransferase 1 Mesocricetus auratus 5-9 8291057-17 1994 1.5/H-NAT2 congenic lines provide a new model for investigating the precise role of the NAT2 gene locus in arylamine metabolism and toxicity. aniline 107-116 arylamine N-acetyltransferase 2 Mesocricetus auratus 6-10 8291057-17 1994 1.5/H-NAT2 congenic lines provide a new model for investigating the precise role of the NAT2 gene locus in arylamine metabolism and toxicity. aniline 107-116 arylamine N-acetyltransferase 2 Mesocricetus auratus 88-92 8466518-1 1993 Polymorphic N-acetyltransferase (NAT2), which exists in the human liver and metabolizes a wide spectrum of arylamine, is encoded by one gene (NAT2). aniline 107-116 N-acetyltransferase 2 Homo sapiens 33-37 8353847-0 1993 Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. aniline 41-50 N-acetyltransferase 1 Homo sapiens 84-88 8353847-0 1993 Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. aniline 41-50 N-acetyltransferase 2 Homo sapiens 105-109 8353847-4 1993 In order to assess the relative ability of NAT1 and NAT2 to activate and deactivate arylamine carcinogens, we tested the capacity of recombinant human NAT1 and NAT2, expressed in Escherichia coli XA90 strains DMG100 and DMG200 respectively, to catalyze the N-acetylation (deactivation) and O-acetylation (activation) of a variety of carbocyclic and heterocyclic arylamine carcinogens. aniline 84-93 N-acetyltransferase 1 Homo sapiens 43-47 8353847-5 1993 Both NAT1 and NAT2 catalyzed the N-acetylation of each of the 17 arylamines tested. aniline 65-75 N-acetyltransferase 1 Homo sapiens 5-9 8353847-5 1993 Both NAT1 and NAT2 catalyzed the N-acetylation of each of the 17 arylamines tested. aniline 65-75 N-acetyltransferase 2 Homo sapiens 14-18 8353847-6 1993 Rates of N-acetylation by NAT1 and NAT2 were considerably lower for heterocyclic arylamines such as 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ), particularly those (e.g. IQ) with steric hindrance to the exocyclic amino group. aniline 81-91 N-acetyltransferase 1 Homo sapiens 26-30 8353847-6 1993 Rates of N-acetylation by NAT1 and NAT2 were considerably lower for heterocyclic arylamines such as 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ), particularly those (e.g. IQ) with steric hindrance to the exocyclic amino group. aniline 81-91 N-acetyltransferase 2 Homo sapiens 35-39 8353847-8 1993 NAT1/NAT2 activity ratios and clearance calculations suggest a significant role for the polymorphic NAT2 in the N-acetylation of carbocyclic arylamine carcinogens. aniline 141-150 N-acetyltransferase 1 Homo sapiens 0-4 8353847-8 1993 NAT1/NAT2 activity ratios and clearance calculations suggest a significant role for the polymorphic NAT2 in the N-acetylation of carbocyclic arylamine carcinogens. aniline 141-150 N-acetyltransferase 2 Homo sapiens 5-9 8353847-8 1993 NAT1/NAT2 activity ratios and clearance calculations suggest a significant role for the polymorphic NAT2 in the N-acetylation of carbocyclic arylamine carcinogens. aniline 141-150 N-acetyltransferase 2 Homo sapiens 100-104 8396914-1 1993 Many arylamine and hydrazine drugs and xenobiotics are acetylated by liver N-acetyltransferase (NAT; EC 2.3.1.5). aniline 5-14 bromodomain containing 2 Homo sapiens 75-94 8396914-1 1993 Many arylamine and hydrazine drugs and xenobiotics are acetylated by liver N-acetyltransferase (NAT; EC 2.3.1.5). aniline 5-14 bromodomain containing 2 Homo sapiens 96-99 8396914-8 1993 NAT has been characterized in immortalized human cell lines to assess their use in studies of the metabolism or arylamines in vitro. aniline 112-122 bromodomain containing 2 Homo sapiens 0-3 8466518-1 1993 Polymorphic N-acetyltransferase (NAT2), which exists in the human liver and metabolizes a wide spectrum of arylamine, is encoded by one gene (NAT2). aniline 107-116 N-acetyltransferase 2 Homo sapiens 142-146 8460938-7 1993 The monooxygenase activities of the purified human brain P450s were demonstrated with various substrates (aminopyrine, morphine, aniline, 7-ethoxycoumarin, and nifedipine) as examined in reconstituted systems consisting of purified human brain P450, purified rat brain NADPH cytochrome P450 reductase, deoxycholate, phospholipid, and NADPH. aniline 129-136 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 57-61 8382984-0 1993 Differential regulation of arylamine and arylalkylamine N-acetyltransferases in human retinoblastoma (Y-79) cells. aniline 27-36 RB transcriptional corepressor 1 Homo sapiens 86-100 8443210-5 1993 Both P-450ST-1 and -ST-2 catalyzed the metabolism of aniline, benzphetamine, p-nitroanisole, testosterone and aminopyrine. aniline 53-60 interleukin 1 receptor-like 1 Rattus norvegicus 5-24 8382984-3 1993 In contrast, treatment with butyrate showed a delayed (3-5 days) increase (3-5-fold) in arylamine NAT activity but not in arylalkylamine NAT activity. aniline 88-97 bromodomain containing 2 Homo sapiens 98-101 1306334-3 1992 Different P450 forms are responsible for activation of the various classes of chemical carcinogens including the arylamines, polycyclic aromatic hydrocarbons, nitrosamines and aflatoxins. aniline 113-123 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 10-14 8434128-5 1993 These results indicate that solvents frequently used to solubilize arylamines may have significant inhibitory activity towards NAT in vitro. aniline 67-77 N-acetyltransferase 1 Rattus norvegicus 127-130 1493607-9 1992 Based on these results it is concluded that the cytochrome P-450 dependent aromatic hydroxylation of monofluoroanilines does not proceed by hydrogen or electron abstraction from the aniline substrate to give an aniline-NH. aniline 111-118 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 48-64 1416970-8 1992 Kinetic parameters (Vmax and Km) of H2O2- and cumene hydroperoxide-dependent oxidation of benzphetamine and aniline in the presence of cytochrome P450 LM2 oligomers, monomers, and microsomes were determined. aniline 108-115 cytochrome P450 2B4 Oryctolagus cuniculus 135-154 1445245-4 1992 In a reconstituted system, ha P-450j showed relatively low catalytic activities towards 7-ethoxycoumarin, 7-ethoxyresorufin, aminopyrine, ethylmorphine and benzphetamine, whereas it catalysed the oxidation of aniline, acetone and thiobenzamide with a high catalytic-centre activity. aniline 209-216 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 30-36 1445245-8 1992 Thiobenzamide and diethyldithiocarbamate were found to be the most effective inhibitors of the ha-P-450j-dependent aniline hydroxylation. aniline 115-122 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 98-104 1383750-1 1992 Using an O-acetyltransferase-overexpressing strain Salmonella typhimurium NM2009 we measured the activities for metabolic activation of several carcinogenic arylamines to genotoxic products by rat liver microsomal cytochrome P-450 enzymes, and compared them with the activities obtained in the original tester strain Salmonella typhimurium TA1535/pSK1002 or the O-acetyltransferase-defective strain Salmonella typhimurium NM2000. aniline 157-167 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 214-230 1344831-4 1992 Omeprazole interacts with the cytochrome P-450 system in the liver: inhibition of several liver mono-oxygenases activities (inhibitory effect on diazepam, phenytoin and R-warfarin metabolism with prolonged elimination); induction of P-450 (IA1 and IA2) enzymes that may potentiate the hepatotoxic effect of phenacetin and acetaminophen or increase the tumorigenic effect of chemical carcinogens (polycyclic aromatic hydrocarbons, arylamines, aflatoxin). aniline 430-440 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 30-46 8442668-1 1993 The human N-acetylation polymorphism is a genetic trait phenotypically reflected by differences in N-acetyltransferase (NAT) activity with therapeutic agents (rapid and slow acetylation), but a genetic invariability in N-acetylation of some arylamine drugs is also known. aniline 241-250 bromodomain containing 2 Homo sapiens 99-118 8442668-1 1993 The human N-acetylation polymorphism is a genetic trait phenotypically reflected by differences in N-acetyltransferase (NAT) activity with therapeutic agents (rapid and slow acetylation), but a genetic invariability in N-acetylation of some arylamine drugs is also known. aniline 241-250 bromodomain containing 2 Homo sapiens 120-123 8425184-11 1993 A second isozyme (NAT1) also catalyzed the N-acetylation of each arylamine as well as the metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene to DNA adducts at rates that were independent of acetylator genotype. aniline 65-74 arylamine N-acetyltransferase 1 Mesocricetus auratus 18-22 8425184-15 1993 For each of the arylamines tested, both apparent Km and apparent Vmax were higher for NAT2 than NAT1. aniline 16-26 arylamine N-acetyltransferase 2 Mesocricetus auratus 86-90 8425184-15 1993 For each of the arylamines tested, both apparent Km and apparent Vmax were higher for NAT2 than NAT1. aniline 16-26 arylamine N-acetyltransferase 1 Mesocricetus auratus 96-100 1423830-8 1992 Quantitative differences in adduct formation between IQ and N-acetyl-IQ indicated that metabolic activation of these arylamines preferentially occurs by P4501A2-catalyzed N-hydroxylation followed by O-acetylation mediated through NAT1 and/or NAT2. aniline 117-127 N-acetyltransferase 1 Homo sapiens 230-234 1423830-8 1992 Quantitative differences in adduct formation between IQ and N-acetyl-IQ indicated that metabolic activation of these arylamines preferentially occurs by P4501A2-catalyzed N-hydroxylation followed by O-acetylation mediated through NAT1 and/or NAT2. aniline 117-127 N-acetyltransferase 2 Homo sapiens 242-246 1423839-3 1992 The activation of NDMA and NNN by liver microsomes was suggested to be catalyzed more actively by P450 2E1 than by other P450 enzymes because the activities were well correlated with NDMA N-demethylation and aniline p-hydroxylation in different human samples, and purified P450 2E1 had the highest activities in reconstituted monooxygenase systems. aniline 208-215 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 98-102 1423839-3 1992 The activation of NDMA and NNN by liver microsomes was suggested to be catalyzed more actively by P450 2E1 than by other P450 enzymes because the activities were well correlated with NDMA N-demethylation and aniline p-hydroxylation in different human samples, and purified P450 2E1 had the highest activities in reconstituted monooxygenase systems. aniline 208-215 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 121-125 1423839-3 1992 The activation of NDMA and NNN by liver microsomes was suggested to be catalyzed more actively by P450 2E1 than by other P450 enzymes because the activities were well correlated with NDMA N-demethylation and aniline p-hydroxylation in different human samples, and purified P450 2E1 had the highest activities in reconstituted monooxygenase systems. aniline 208-215 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 121-125 1441598-8 1992 NAT2 gene locus is the site of the human acetylation polymorphism, because its products NAT2A and NAT2B selectively acetylate "polymorphic" arylamine substrates (e.g. sulphamethazine), and since the liver content of these isozymes is markedly reduced in genetically slow acetylator subjects. aniline 140-149 N-acetyltransferase 2 Homo sapiens 0-4 1321442-1 1992 Flash photolysis has been used to effect electron transfer from tris(2,2"-bipyridyl)ruthenium(II) to cytochrome c oxidase in the presence of a sacrificial electron donor, aniline. aniline 171-178 cytochrome c, somatic Homo sapiens 101-113 24243047-5 1992 With model C-8 substituted arylamine adducts [N-(deoxyguanosin-8-yl)-4-aminobiphenyl, N-(deoxyadenosin--yl)-4-aminobiphenyl, and N-(deoxyguanosin-8-yl)-2-aminofluorene], nucleoside-specific and carcinogen-specific fragmentation have been observed in daughter ion spectra. aniline 27-36 homeobox C8 Homo sapiens 11-14 1356735-8 1992 These results imply that susceptibility of individuals to arylamine-induced bladder cancer might be associated with NAT activities in their target cells and that in vivo acetylator phenotyping could serve as a useful and relevant biochemical screening marker to assess the risk of developing bladder cancer. aniline 58-67 bromodomain containing 2 Homo sapiens 116-119 1895098-4 1991 Similarity of the liver enzymes and the pineal gland arylalkylamine N-acetyltransferase (AA-NAT) has been suggested, because pineal gland homogenates were shown to metabolize arylamine substrates as p-phenetidine, aniline, or phenylethylamine, and liver homogenates or partially purified liver enzyme preparations catalyzed the N-acetylation of serotonin. aniline 175-184 serotonin N-acetyltransferase Oryctolagus cuniculus 53-87 1553758-7 1992 These results suggest a significant role for myeloperoxidase in the bioactivation process, which contrasts with the proposed bioactivation mechanism of certain arylamine compounds. aniline 160-169 myeloperoxidase Homo sapiens 45-60 1441335-3 1992 Persons with a length of work over 10 years contacting with anilin and its derivatives showed a marked increase of B2-microglobulin in the blood serum as well a marked reduction of leucocyte number. aniline 60-66 major histocompatibility complex, class I, G Homo sapiens 115-131 1739422-7 1992 The Ki values (+/- SD) for inhibitors of microsomal coumarin 7-hydroxylase activity in vitro were: alpha-naphthoflavone, 46.9 +/- 19.8 nM; metyrapone, 0.8 +/- 0.9 microM; aniline, 12.3 +/- 8.2 microM; cimetidine, 70.9 +/- 27.9 microM; N-nitrosodimethylamine, 0.7 +/- 0.9 mM; and dimethyl sulfoxide, 7.9 +/- 1.9 mM. aniline 171-178 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 52-74 1605725-0 1992 Acetylator genotype-dependent N-acetylation of arylamines in vivo and in vitro by hepatic and extrahepatic organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus. aniline 47-57 arylamine N-acetyltransferase 2 Mesocricetus auratus 169-186 1759389-2 1991 Distinct increase of cytochrome P-450 catalytic activity with amidopyrine and benzo-a-pyrene as substrates of the I type was found after hypoxia, subsequent hyperoxia resulted in significant increase of amidopyrine and benzo-a-pyrene metabolism in liver and lung tissues and of aniline metabolism in liver tissue. aniline 278-285 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 21-37 1872889-4 1991 The second locus encodes an NAT which is termed polymorphic NAT (pNAT), has a distinct tissue distribution and is responsible for the difference in ability between individuals in acetylating certain arylamine (e.g. sulphamethazine) and hydrazine (e.g. isoniazid) drugs which are polymorphic substrates. aniline 199-208 bromodomain containing 2 Homo sapiens 28-31 1872889-4 1991 The second locus encodes an NAT which is termed polymorphic NAT (pNAT), has a distinct tissue distribution and is responsible for the difference in ability between individuals in acetylating certain arylamine (e.g. sulphamethazine) and hydrazine (e.g. isoniazid) drugs which are polymorphic substrates. aniline 199-208 N-acetyltransferase 2 Homo sapiens 48-63 1872889-4 1991 The second locus encodes an NAT which is termed polymorphic NAT (pNAT), has a distinct tissue distribution and is responsible for the difference in ability between individuals in acetylating certain arylamine (e.g. sulphamethazine) and hydrazine (e.g. isoniazid) drugs which are polymorphic substrates. aniline 199-208 N-acetyltransferase 2 Homo sapiens 65-69 1895098-4 1991 Similarity of the liver enzymes and the pineal gland arylalkylamine N-acetyltransferase (AA-NAT) has been suggested, because pineal gland homogenates were shown to metabolize arylamine substrates as p-phenetidine, aniline, or phenylethylamine, and liver homogenates or partially purified liver enzyme preparations catalyzed the N-acetylation of serotonin. aniline 175-184 serotonin N-acetyltransferase Oryctolagus cuniculus 89-95 1687018-3 1991 Formaldehyde production was inhibited by substrates and ligands for cytochrome P-450 such as aniline, p-nitrophenol, pyrazole, and 4-methylpyrazole, and inhibitors such as tryptamine, cimetidine, and miconazole. aniline 93-100 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 68-84 1895098-4 1991 Similarity of the liver enzymes and the pineal gland arylalkylamine N-acetyltransferase (AA-NAT) has been suggested, because pineal gland homogenates were shown to metabolize arylamine substrates as p-phenetidine, aniline, or phenylethylamine, and liver homogenates or partially purified liver enzyme preparations catalyzed the N-acetylation of serotonin. aniline 214-221 serotonin N-acetyltransferase Oryctolagus cuniculus 53-87 1895098-4 1991 Similarity of the liver enzymes and the pineal gland arylalkylamine N-acetyltransferase (AA-NAT) has been suggested, because pineal gland homogenates were shown to metabolize arylamine substrates as p-phenetidine, aniline, or phenylethylamine, and liver homogenates or partially purified liver enzyme preparations catalyzed the N-acetylation of serotonin. aniline 214-221 serotonin N-acetyltransferase Oryctolagus cuniculus 89-95 2054604-2 1991 Relatively high levels of arylamine NAT activity were detected in all areas examined. aniline 26-35 N-acetyltransferase 1 Rattus norvegicus 36-39 1750211-2 1991 Under these conditions cytochrome P-450 catalytic activity with aniline as a substrate was increased by 65-152% and with amidopyrine as a substrate--by 72-148%, respectively. aniline 64-71 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 23-39 2044184-2 1991 However, the present paper shows that aniline hydrochloride induces micronuclei in the bone marrow of male CRH mice 24 h after a single oral dose of 1000 mg/kg (in terms of free base) though not at the lower doses of 400 and 500 mg/kg. aniline 38-59 corticotropin releasing hormone Mus musculus 107-110 2015283-1 1991 Many arylamine and hydrazine drugs and xenobiotics are acetylated by N-acetyltransferase (NAT), a cytosolic enzymic activity which has a wide tissue distribution. aniline 5-14 bromodomain containing 2 Homo sapiens 69-88 2015283-1 1991 Many arylamine and hydrazine drugs and xenobiotics are acetylated by N-acetyltransferase (NAT), a cytosolic enzymic activity which has a wide tissue distribution. aniline 5-14 bromodomain containing 2 Homo sapiens 90-93 1996083-13 1991 In addition, the use of recombinant NAT1 and NAT2 will allow us to predict whether any given arylamine will be polymorphically acetylated in humans. aniline 93-102 N-acetyltransferase 1 Homo sapiens 36-40 1996083-13 1991 In addition, the use of recombinant NAT1 and NAT2 will allow us to predict whether any given arylamine will be polymorphically acetylated in humans. aniline 93-102 N-acetyltransferase 2 Homo sapiens 45-49 2054604-3 1991 Arylalkylamine NAT activity in these areas ranged from 2 to 5% of the arylamine NAT activity. aniline 70-79 N-acetyltransferase 1 Rattus norvegicus 15-18 2054604-3 1991 Arylalkylamine NAT activity in these areas ranged from 2 to 5% of the arylamine NAT activity. aniline 70-79 N-acetyltransferase 1 Rattus norvegicus 80-83 2054604-4 1991 The possibility that arylamine NAT may be involved in the control of kynurenine metabolism in the brain is discussed. aniline 21-30 N-acetyltransferase 1 Rattus norvegicus 31-34 1670761-1 1991 Enzymatic sulfation of N-hydroxylated arylamines by mammalian hepatic cytosol sulfotransferases (AST; EC 2.8.2.1) is an important metabolic step which generates ultimate carcinogens. aniline 38-48 solute carrier family 17 member 5 Homo sapiens 97-100 2048353-0 1991 [Prevention of reduced plasma fibronectin level in acute and chronic phenol and aniline poisoning in rats on vitamin-rich diet]. aniline 80-87 fibronectin 1 Rattus norvegicus 30-41 1673622-2 1991 N-acetyl transferase (NAT) catalyses the acetylation of arylamine and hydrazine drugs and other xenobiotics. aniline 56-65 bromodomain containing 2 Homo sapiens 0-20 1673622-2 1991 N-acetyl transferase (NAT) catalyses the acetylation of arylamine and hydrazine drugs and other xenobiotics. aniline 56-65 bromodomain containing 2 Homo sapiens 22-25 1673622-9 1991 It is concluded that U937 cells are a useful model for studying the metabolism of arylamines and hydrazines by human monomorphic N-acetyl transferase. aniline 82-92 bromodomain containing 2 Homo sapiens 129-149 2048353-3 1991 In acute aniline intoxication, fibronectin concentrations were decreased up to 120-130 mg/l during 4 days, later on its level became higher. aniline 9-16 fibronectin 1 Rattus norvegicus 31-42 2183778-0 1990 Inactivation of mutagenic heterocyclic and aryl amines by linoleic acid 13-monohydroperoxide and methemoglobin. aniline 43-54 hemoglobin subunit gamma 2 Homo sapiens 97-110 2257489-1 1990 A low molecular weight fraction (AG2) containing arylamine compounds has been isolated from venom of the spider Agelenopsis aperta. aniline 49-58 similar to LOC387763 protein Rattus norvegicus 33-36 2219123-1 1990 In rat liver microsomes, 2-methyl-1,4-naphthoquinone (menadione) inhibits cytochrome P450 (cyt P450)-mediated aniline-p-hydroxylation and aminopyrine-N-demethylation with Ki values of 12 and 14.5 microM, respectively. aniline 110-117 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 74-89 2219123-1 1990 In rat liver microsomes, 2-methyl-1,4-naphthoquinone (menadione) inhibits cytochrome P450 (cyt P450)-mediated aniline-p-hydroxylation and aminopyrine-N-demethylation with Ki values of 12 and 14.5 microM, respectively. aniline 110-117 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 91-99 2291963-3 1990 In this period affinity of the fluorescent probe ANS to microsomal membranes and affinity of the cytochrome P-450 to aniline was significantly decreased. aniline 117-124 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 97-113 2306278-5 1990 This reaction was sensitive to inhibition by carbon monoxide and was inhibited by compounds known to be effective substrates for P-450j, e.g. aniline, ethanol, pyrazole and 4-methylpyrazole. aniline 142-149 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 129-135 2134671-10 1990 These results indicate that the NAT phenotype, age and sex are all important determinants of arylamine-DNA adduct formation in mice. aniline 93-102 solute carrier family 38, member 3 Mus musculus 32-35 2322954-0 1990 The role of hydrophobicity and electronic factors in regulating alcohol inhibition of cytochrome P-450-mediated aniline hydroxylation. aniline 112-119 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 86-102 2322954-1 1990 The role of hydrophobicity and electronic factors in regulating alcohol inhibition of cytochrome P-450-mediated aniline p-hydroxylation has been investigated by the formulation of quantitative structure-activity relationships. aniline 112-119 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 86-102 2344458-2 1990 In this system cytochrome P-450 effectuates a steady-state demethylation of dimethylaniline and hydroxylation of aniline. aniline 84-91 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-31 2276339-5 1990 The Kcat/KM values, which indicate the efficiency of enzyme catalysis, for NADPH plus O2-, t-BuOOH, and CumOOH-dependent aniline hydroxylase from EtOH-fed rats were 102, 37, and 5 and from pair-fed rats were 68, 4, and 4 (nmol p-aminophenol/min/nmol cytochrome P-450)/mM aniline, respectively. aniline 121-128 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 250-266 34500150-4 2022 The catalytic performance of Pd@CTF-1 was demonstrated by the one-pot N-alkylation of benzaldehyde with aniline (or nitrobenzene) under mild reaction conditions, and Pd@CTF-1 exhibited a wide range of general applicability for N-alkylation reactions. aniline 104-111 cardiotrophin 1 Homo sapiens 32-37 24309420-11 2014 However, a slow acetylation phenotype or inhibition of NAT2 could lead to decreased N-acetylation and hence leading to an increased risk of side effects caused by this arylamine. aniline 168-177 N-acetyltransferase 2 Homo sapiens 55-59 34500150-4 2022 The catalytic performance of Pd@CTF-1 was demonstrated by the one-pot N-alkylation of benzaldehyde with aniline (or nitrobenzene) under mild reaction conditions, and Pd@CTF-1 exhibited a wide range of general applicability for N-alkylation reactions. aniline 104-111 cardiotrophin 1 Homo sapiens 169-174 34773126-9 2022 Our metabolic and detoxification mechanistic studies revealed significantly higher rates of N-acetylation, NAT-1 activity and higher detoxification of P2-P4 in keratinocytes, suggesting the importance of nucleophilic groups at the ortho position in PPD to reduce toxicity of aniline-based dyes on human skin cells. aniline 275-282 N-acetyltransferase 1 Homo sapiens 107-112 34390422-0 2021 Correction to: Switch-on effect on conformation-specific arylamine-DNA adduct by cyclometalated Ir(III) complexes. aniline 57-66 insulin receptor Homo sapiens 96-103 34282315-1 2021 A series of analogs of vegfrecine, a natural quinone vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, was synthesized via oxidative amination of 2,5-dihydroxybenzamide with functionalized arylamine followed by ammonolysis and substitution of the quinone ring. aniline 218-227 kinase insert domain receptor Homo sapiens 98-103 34270204-4 2021 The dynamically cross-linked chitosan (CS) and the flexible polyacrylamide network doped with polyaniline constitute the DN through the hydrogen bonds between the hydroxyl, amide, and aniline groups. aniline 184-191 citrate synthase Homo sapiens 39-41 34430302-6 2021 One-pot catalytic amination of cyclohexanone with aniline was performed efficiently in liquid phase on Pd/C. aniline 50-57 phosducin Homo sapiens 103-107 35301062-4 2022 Using aniline as probe, we compared the enzyme kinetics of hepatic CYP2E1 between two groups. aniline 6-13 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 67-73 34123322-6 2021 1H NMR kinetic analysis of salt degradation has evidenced thermal degradation to methyl iodide and the parent aniline, consistent with a closed-shell SN2-centred degradative pathway, and methyl iodide being the key reactive species in applied methylation procedures. aniline 110-117 solute carrier family 38 member 5 Homo sapiens 150-153 35587543-5 2022 RESULTS: A glucose biosensor was constructed using polyaniline (PANI) and a recombinant enzyme from corn, Plant-produced manganese peroxidase (PPMP), with polymerization of aniline as a monomer in the presence of gold nanoparticles (AuNPs)- glucose oxidase (GOx), and bovine serum albumin (BSA). aniline 173-180 hydroxyacid oxidase 1 Homo sapiens 241-256 35587543-5 2022 RESULTS: A glucose biosensor was constructed using polyaniline (PANI) and a recombinant enzyme from corn, Plant-produced manganese peroxidase (PPMP), with polymerization of aniline as a monomer in the presence of gold nanoparticles (AuNPs)- glucose oxidase (GOx), and bovine serum albumin (BSA). aniline 173-180 hydroxyacid oxidase 1 Homo sapiens 258-261 35587543-5 2022 RESULTS: A glucose biosensor was constructed using polyaniline (PANI) and a recombinant enzyme from corn, Plant-produced manganese peroxidase (PPMP), with polymerization of aniline as a monomer in the presence of gold nanoparticles (AuNPs)- glucose oxidase (GOx), and bovine serum albumin (BSA). aniline 173-180 albumin Homo sapiens 275-288 35589718-4 2022 A turnover frequency of approximately 8000 h-1 that corresponds to an aniline productivity of 5.8 g h-1 is achieved with a bench-top flow module (nominal reservoir volume of 1 cm3), with a Pt1-MoS2 catalyst loading of 1.5 g (3.2 mg of Pt). aniline 70-77 zinc finger protein 77 Homo sapiens 189-192 35441182-8 2022 DFT calculations also reveal that apart from the one-electron transfer pathway between aniline and SPS, the two-electron transfer pathway is also likely to occur in the presence of phenol, resulting in the formation of PhNH+/PhN without producing PhNH2 + and PhNH . aniline 87-94 carbamoyl-phosphate synthase 1 Homo sapiens 225-228 35441182-9 2022 The produced PhNH+/PhN intermediates then couple with aniline, PhNH+, aminophenyl sulfate and its hydrolysate to form dimers, trimers, oligomers, and eventually OANIblue. aniline 56-63 carbamoyl-phosphate synthase 1 Homo sapiens 19-22 35212189-3 2022 The aniline para substituent and catechol within the amidoboronates tuned the rac5 /rac6 ratio; the rac6 isomer predominated for amidoboronates based on pyrocatechol, ranging from a ratio of 0 : 1 with electron-withdrawing Cl substituents to 0.5 : 0.5 for electron-donating NMe2 substituents. aniline 4-11 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 274-278 35353990-8 2022 Arylamine N-acetyltransferase activity was determined with selective substrates for NAT1 (p-aminobenzoic acid; PABA) and NAT2 (sulfamethazine; SMZ) in the presence and absence of a selective NAT1 inhibitor. aniline 0-9 N-acetyltransferase 1 Homo sapiens 84-88 35353990-8 2022 Arylamine N-acetyltransferase activity was determined with selective substrates for NAT1 (p-aminobenzoic acid; PABA) and NAT2 (sulfamethazine; SMZ) in the presence and absence of a selective NAT1 inhibitor. aniline 0-9 N-acetyltransferase 2 Homo sapiens 121-125 35417177-3 2022 To integrate these two features into one material, here, dual-dynamic covalent bonds (imines and boronic esters) and aniline trimer (ACAT) were incorporated into the styrene butadiene elastomer as dynamic cross-links. aniline 117-124 sterol O-acyltransferase 1 Homo sapiens 133-137 35356686-1 2022 This investigation is focused on the synthesis of two halo-functionalized crystalline Schiff base (imine) compounds: (E)-2-methoxy-6-(((3-(trifluoromethyl)phenyl)imino)methyl)phenol (MFIP) and (E)-1-(((2-fluorophenyl)imino)methyl)naphthalen-2-ol (FPIN) by the condensation reaction of substituted benzaldehydes and substituted aniline. aniline 327-334 cystatin 12, pseudogene Homo sapiens 117-122 35408491-3 2022 Under optimized pretreatment conditions, the linearity of the method ranged from 0.5 to 20 mug mL-1 for aniline, and the correlation coefficient was 0.999. aniline 104-111 L1 cell adhesion molecule Mus musculus 95-99 35124201-3 2022 Presented aniline-type conjugates exhibit significant cytotoxic activity in MV4-11 and EOL-1 cell lines which correlates with FLT3-ITD and PDGFRalpha inhibition. aniline 10-17 platelet derived growth factor receptor alpha Homo sapiens 139-149 35356686-1 2022 This investigation is focused on the synthesis of two halo-functionalized crystalline Schiff base (imine) compounds: (E)-2-methoxy-6-(((3-(trifluoromethyl)phenyl)imino)methyl)phenol (MFIP) and (E)-1-(((2-fluorophenyl)imino)methyl)naphthalen-2-ol (FPIN) by the condensation reaction of substituted benzaldehydes and substituted aniline. aniline 327-334 small nucleolar RNA, H/ACA box 73A Homo sapiens 193-198 2583181-15 1989 All the enzymes preferred arylamines to arylalkylamines, indicating that both p-NAT-3 and p-NAT-10 cDNAs encoded arylamine N-acetyltransferases. aniline 26-36 arylamine N-acetyltransferase, pineal gland isozyme NAT-3 Gallus gallus 78-85 35273499-1 2022 Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). aniline 76-85 N-acetyltransferase 1 Homo sapiens 6-37 35273499-1 2022 Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). aniline 76-85 N-acetyltransferase 1 Homo sapiens 39-43 2598935-13 1989 H2O2-dependent N-demethylation of benzphetamine and aniline p-hydroxylation by cytochrome P-450 LM2 did not depend on its state of aggregation. aniline 52-59 cytochrome P450 2B4 Oryctolagus cuniculus 79-99 2632083-2 1989 In vitro, M-1 and M-2, which are the beta-oxidized form and the reduced form of OZA, respectively, inhibited aminopyrine N-demethylation, aniline hydroxylation and testosterone hydroxylations in mouse hepatic microsomes and produced type II difference spectra in the same manner as OZA. aniline 138-145 UDP glucuronosyltransferase 2 family, polypeptide B5 Mus musculus 10-13 2632083-2 1989 In vitro, M-1 and M-2, which are the beta-oxidized form and the reduced form of OZA, respectively, inhibited aminopyrine N-demethylation, aniline hydroxylation and testosterone hydroxylations in mouse hepatic microsomes and produced type II difference spectra in the same manner as OZA. aniline 138-145 cholinergic receptor, muscarinic 2, cardiac Mus musculus 18-21 2583181-15 1989 All the enzymes preferred arylamines to arylalkylamines, indicating that both p-NAT-3 and p-NAT-10 cDNAs encoded arylamine N-acetyltransferases. aniline 26-36 N-acetyltransferase 10 Gallus gallus 92-98 2618079-4 1989 Exposure of aniline-metabolizing hepatocytes to p-chloro-mercuribenzoate (PCMB) or p-chloromercuribenzenesulphonic acid (PCMBS) resulted in decreased levels of cytochrome P-450, decreased glucuronidation of 4-aminophenol and increased levels of free 4-aminophenol. aniline 12-19 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 160-176 2618079-8 1989 Exposure of aniline-metabolizing hepatocytes to mersalyl, 2,2"-dithiodipyridine (DTP), 6,6"-carboxydipyridine disulphide (CPDS) or N-ethylmaleimide did not affect the biotransformation of aniline or cytochrome P-450 levels. aniline 12-19 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 199-215 2618079-13 1989 PCMB and PCMBS inhibited aniline metabolism, probably by binding to a cysteinyl-SH residue in cytochrome P-450 apoenzyme and "active sites" of UDP-glucuronyl transferases. aniline 25-32 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 94-110 2477842-1 1989 The dioxin-inducible cytochrome P(1)450 (Cyp1a1 gene) and P(3)450 (Cyp1a2 gene) enzymes have been implicated in the metabolism of numerous polycyclic hydrocarbons and arylamines, respectively. aniline 167-177 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 41-47 2477842-1 1989 The dioxin-inducible cytochrome P(1)450 (Cyp1a1 gene) and P(3)450 (Cyp1a2 gene) enzymes have been implicated in the metabolism of numerous polycyclic hydrocarbons and arylamines, respectively. aniline 167-177 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 67-73 2911085-0 1989 Selective mutagenic activation by cytochrome P3-450 of carcinogenic arylamines found in foods. aniline 68-78 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 34-51 2485128-10 1989 Myeloperoxidase appears to be much more important in the binding of acetaminophen to DNA than it is in the DNA binding of arylamines in general. aniline 122-132 myeloperoxidase Homo sapiens 0-15 2568902-3 1989 In this study, arylamine NAT activity was partially purified and characterized in inbred hamster urinary bladder cytosols of defined acetylator genotype. aniline 15-24 bromodomain containing 2 Homo sapiens 25-28 2568902-5 1989 Partial purification of hamster bladder cytosol by anion-exchange fast protein liquid chromatography yielded two NAT isozymes that catalyzed the N-acetylation of each of the arylamine substrates. aniline 174-183 bromodomain containing 2 Homo sapiens 113-116 2568902-9 1989 These results suggest a key role for a polymorphic NAT isozyme, regulated by the acetylator genotype and expressed in urinary bladder cytosol, in the initiation of bladder cancer via arylamine carcinogens. aniline 183-192 bromodomain containing 2 Homo sapiens 51-54 2750202-4 1989 After the removal of aniline, N-methylaniline and DMA, treatment of the media with either strong acid or beta-glucuronidase, resulted in the release of N-methylaniline, identified by chromatography and mass spectrometry. aniline 21-28 glucuronidase, beta Rattus norvegicus 105-123 2730881-1 1989 On the basis of optical difference spectra, lactoperoxidase (LPO) was shown to form a 1:1 complex with aromatic donor molecules: resorcinol, hydroquinone, phenol, p-cresol, guaiacol, aniline, and benzohydroxamic acid. aniline 183-190 lactoperoxidase Homo sapiens 44-59 2730881-1 1989 On the basis of optical difference spectra, lactoperoxidase (LPO) was shown to form a 1:1 complex with aromatic donor molecules: resorcinol, hydroquinone, phenol, p-cresol, guaiacol, aniline, and benzohydroxamic acid. aniline 183-190 lactoperoxidase Homo sapiens 61-64 2911085-2 1989 The purpose of this investigation was to determine the specificity of cytochromes P1-450 and P3-450 toward the metabolic activation of these arylamines. aniline 141-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-99 2911085-5 1989 Cytochrome P1-450 showed little or no activation of these arylamines but was the isoform predominantly responsible for the activation of the aromatic hydrocarbon benzo[a]pyrene-7,8-diol. aniline 58-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 11-17 2807635-1 1989 The effect of endotoxin in decreasing the cytochrome P-450-dependent metabolism of aniline, aminopyrine and ethoxycoumarin was examined in untreated rats, and in rats pretreated with either phenobarbital or 3-methylcholanthrene. aniline 83-90 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 42-58 2807635-11 1989 The data suggest that endotoxin may differentially affect the various isozymes of cytochrome P-450 associated with the metabolism of aniline, aminopyrine and ethoxycoumarin. aniline 133-140 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 82-98 2754757-0 1989 Effect of carbon monoxide on the cytochrome P-450-mediated metabolism of aniline and p-nitroanisole in the isolated perfused rabbit lung. aniline 73-80 cytochrome P-450 Oryctolagus cuniculus 33-49 3127944-5 1988 The degree of enhancement of CS2 metabolism by different alcohols paralleled the enhancement of nitroanisole O-demethylation and aniline hydroxylation, MFO activities associated with the ethanol-inducible isozyme of cytochrome P450. aniline 129-136 calsyntenin 2 Rattus norvegicus 29-32 3218159-7 1988 The high concentration of cytochrome P-450 (in the homogenate and microsomes) correlated with the acceleration of hydroxylation of standard substrates ethylmorphine and aniline. aniline 169-176 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 26-42 3148724-8 1988 When reconstituted with NADPH-cytochrome P-450 reductase and dilauroylphosphatidylcholine, cytochromes P-450b and P-450b* catalyzed the N-demethylation of benzphetamine and aminopyrine, the 4-hydroxylation of aniline, the O-dealkylation of 7-ethoxycoumarin, the 3-hydroxylation of hexobarbital, and the 6-hydroxylation of zoxazolamine. aniline 209-216 cytochrome p450 oxidoreductase Rattus norvegicus 24-56 3148724-8 1988 When reconstituted with NADPH-cytochrome P-450 reductase and dilauroylphosphatidylcholine, cytochromes P-450b and P-450b* catalyzed the N-demethylation of benzphetamine and aminopyrine, the 4-hydroxylation of aniline, the O-dealkylation of 7-ethoxycoumarin, the 3-hydroxylation of hexobarbital, and the 6-hydroxylation of zoxazolamine. aniline 209-216 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 103-109 3148724-8 1988 When reconstituted with NADPH-cytochrome P-450 reductase and dilauroylphosphatidylcholine, cytochromes P-450b and P-450b* catalyzed the N-demethylation of benzphetamine and aminopyrine, the 4-hydroxylation of aniline, the O-dealkylation of 7-ethoxycoumarin, the 3-hydroxylation of hexobarbital, and the 6-hydroxylation of zoxazolamine. aniline 209-216 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 114-120 3415646-3 1988 The oxidation of aniline or aminopyrine and the cytochrome P-450/oxygen-radical-independent oxidation of ethanol also displayed a biphasic response to the concentration of O2, reaching a maximum at 20% O2, which correlates with the dithionite-reducible CO-binding spectra of cytochrome P-450. aniline 17-24 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 275-291 3420813-1 1988 Content and catalytic activity of cytochrome P-450 were studied using amidopyrine as a substrate of the I type and aniline as a substrate of the II type. aniline 115-122 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-50 3358786-5 1988 Antibody to rabbit ethanol-inducible cytochrome P-450 (isozyme 3a) inhibited over 80% of the aniline (high affinity) and p-nitrophenol hydroxylase activities of microsomes from ethanol-treated hamsters. aniline 93-100 cytochrome P-450 Oryctolagus cuniculus 37-65 3358786-11 1988 This isozyme can be readily monitored by either high-affinity aniline or p-nitrophenol hydroxylation or by Western immunoblot analysis and appears to be the ethanol-inducible form of cytochrome P-450 in hamsters. aniline 62-69 cytochrome P450 2A3-like Mesocricetus auratus 183-199 3073025-0 1988 Inactivation of mutagenic heterocyclic and aryl amines by linoleic acid 13-monohydroperoxide and methemoglobin. aniline 43-54 hemoglobin subunit gamma 2 Homo sapiens 97-110 2485131-7 1988 Studies on the possible role of the granulocyte enzyme myeloperoxidase in the activation and binding of these arylamines were conducted in vitro and also through the use of azide, an inhibitor of myeloperoxidase activity in cells. aniline 110-120 myeloperoxidase Homo sapiens 55-70 2485131-7 1988 Studies on the possible role of the granulocyte enzyme myeloperoxidase in the activation and binding of these arylamines were conducted in vitro and also through the use of azide, an inhibitor of myeloperoxidase activity in cells. aniline 110-120 myeloperoxidase Homo sapiens 196-211 2485131-8 1988 The results indicate that myeloperoxidase probably plays only a limited role in causing the covalent binding of arylamines to nucleic acid in human granulocytes. aniline 112-122 myeloperoxidase Homo sapiens 26-41 2485131-9 1988 It is probable that other reactive oxygen species, which are not dependent upon myeloperoxidase for their production, are necessary for the bioactivation of some arylamines, especially for substrates such as 4-nitroaniline. aniline 162-172 myeloperoxidase Homo sapiens 80-95 3209851-9 1988 These congenic strains will be important in determining the role of the NAT genotype in susceptibility to arylamine-induced cancer and other disorders. aniline 106-115 solute carrier family 38, member 3 Mus musculus 72-75 3416296-6 1988 The hepatic microsomal NADPH-dependent metabolism of benzene was inhibited by compounds known to interact with the ethanol-inducible form of P-450 such as imidazole, ethanol, aniline, and acetone but was unaffected by addition of metyrapone. aniline 175-182 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 141-146 3043944-2 1988 The effect of omeprazole on the microsomal ethanol oxidizing system (MEOS) and, since ethanol-induced cytochrome P-450 reveals a high activity for aniline hydroxylation, on aniline hydroxylase (AH) has been investigated in rat liver microsomes. aniline 147-154 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 102-118 3043944-4 1988 These data give indirect evidence that the microsomal metabolism of both ethanol and aniline is mediated by different isoenzymes of cytochrome P-450 and that omeprazole exhibits a different affinity to both compounds. aniline 85-92 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 132-148 3126736-4 1988 Other pyrazoline derivatives such as BW 755C, but also, in a more general manner, different compounds containing phenol, aniline, hydrazine, hydroxylamine or hydrazide functions act as reducing substrates for decomposition of 13-HPOD by L1. aniline 121-128 seed linoleate 13S-lipoxygenase-1 Glycine max 237-239 3277033-5 1988 In addition, cytochrome P-450j-catalyzed enzymatic activities, aniline hydroxylation, and N-nitrosodimethylamine N-demethylation were increased by the diabetic state at this same time period. aniline 63-70 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 13-30 3337722-2 1988 These compounds inhibit oxidation and binding of the substrates of cytochrome P-450 (aminopyrine and aniline), inhibition being of a competitive character. aniline 101-108 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-83 3335529-9 1988 The catalytic activity of the pyrazole cytochrome P-450 was elevated with aniline and dimethylnitrosamine (low Km) but not with aminopyrine, benzphetamine, ethoxycoumarin, or ethoxyresorufin as substrates. aniline 74-81 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 39-55 2964867-4 1987 In the presence of tyrosinase, arylamines and o-aminophenols are converted to o-quinone imines, which are isolated as quinone anils or phenoxazones. aniline 31-41 tyrosinase Homo sapiens 19-29 2964867-8 1987 The enzymatic conversion of arylamines by tyrosinase is different from the typical ones: N-oxidation and ring hydroxylation without further oxidation. aniline 28-38 tyrosinase Homo sapiens 42-52 3675576-3 1987 In a reconstituted system, P-450-ALC oxidizes ethanol and aniline at turnover rates (12.2 and 7.3 nmol min-1, respectively) 10-fold greater than two other human P-450 isozymes (termed P-450-B and P-450-C) purified from the same liver. aniline 58-65 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 27-36 3675576-3 1987 In a reconstituted system, P-450-ALC oxidizes ethanol and aniline at turnover rates (12.2 and 7.3 nmol min-1, respectively) 10-fold greater than two other human P-450 isozymes (termed P-450-B and P-450-C) purified from the same liver. aniline 58-65 CD59 molecule (CD59 blood group) Homo sapiens 103-108 3691783-2 1987 A considerable depth of aniline metabolism inhibition following hepatic ischemia is related to reduced affinity of cytochrome P-450 to substrates of type II. aniline 24-31 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 115-131 3691783-4 1987 Administration of alpha-tocopherol in combination with lidocaine prevented a decrease of the rate of amidopyrine N-demethylation, the concentrations of cytochromes P-450, b5 and prevented a reduction of cytochrome P-450 affinity to aniline. aniline 232-239 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 203-219 3800390-9 1986 P-450ac also catalyzed the oxygenation of N-nitrosomethylethylamine and aniline and the activity was enhanced slightly by cytochrome b5. aniline 72-79 cytochrome b5 type A Rattus norvegicus 122-135 3308889-3 1987 One enzyme, termed RLM6, metabolizes aniline and acetol, but not testosterone, in a reconstituted system with NADPH-cytochrome P-450 reductase. aniline 37-44 cytochrome p450 oxidoreductase Rattus norvegicus 110-142 3308889-10 1987 The other form of cytochrome P-450, RLM5b, does not metabolize aniline and only poorly metabolizes acetol and testosterone. aniline 63-70 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 18-34 3621372-0 1987 Quantitative structure-activity relationships in a series of alcohols exhibiting inhibition of cytochrome P-450-mediated aniline hydroxylation. aniline 121-128 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 95-111 3441474-3 1987 The frequencies of cytochrome P-450-dependent biotransformations of substrates aminopyrine and aniline are also of different directions. aniline 95-102 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 19-35 3107803-0 1987 Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines. aniline 85-92 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 51-67 3493777-3 1987 Poor correlation was seen between P-450 HFLa level and the activity of benzphetamine N-demethylation or aniline hydroxylation. aniline 104-111 cytochrome P450 family 3 subfamily A member 7 Homo sapiens 34-44 3101674-2 1986 The presence of a very active cytochrome P-450-dependent drug-metabolizing system in the olfactory epithelium has been confirmed by using 7-ethoxycoumarin, 7-ethoxyresorufin, hexobarbitone and aniline as substrates, and the reasons for the marked activity of the cytochrome P-450 in this tissue have been investigated. aniline 193-200 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 30-46 3997827-7 1985 In contrast, cytochrome P-450j effectively catalyzes p-hydroxylation of aniline with a turnover of 12.7 nmol/min/nmol cytochrome P-450j. aniline 72-79 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 13-30 3011493-2 1986 Insulin decreases aniline binding with cytochrome P-450 and the rate of its p-hydroxylation (after 6, 12 hours), the content of cytochrome P-450 and the rate of NADP.H oxidation (after 12 hours), the rate of NAD.H oxidation (after 24 hours). aniline 18-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 39-55 3702151-0 1986 Effects of cytochrome b5 on aniline hydroxylation catalyzed by a reconstituted system containing acetone or 2,2"-bipyridine. aniline 28-35 cytochrome b5 type A Homo sapiens 11-24 4063403-1 1985 It has been shown that sodium azide, a catalase inhibitor, accelerates the inactivation of cytochrome P-450 in reactions of hydroxylation of type I substrates, e.g., dimethylaniline (DMA), aminopyrine (AP), benzphetamine (BPh), p-nitroanisole (p-Na) and type II substrates--aniline (AN). aniline 272-281 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 91-107 4016117-3 1985 The compounds inhibit oxidation and binding of cytochrome P-450 substrates of type I (naphthalene, aminopyrine) and of type II (aniline). aniline 128-135 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-63 3518633-3 1986 Both preparations of cytochrome P-450j have high catalytic activity in aniline hydroxylation, butanol oxidation, and N-nitrosodimethylamine demethylation with turnover numbers of 17-18, 37-46, and 15 nmol product/min/nmol of P-450, respectively. aniline 71-78 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 21-38 3518633-9 1986 Aniline hydroxylation catalyzed by the reconstituted system containing cytochrome P-450j is markedly inhibited (greater than 90%) by antibody to the rabbit protein. aniline 0-7 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 82-88 3997827-7 1985 In contrast, cytochrome P-450j effectively catalyzes p-hydroxylation of aniline with a turnover of 12.7 nmol/min/nmol cytochrome P-450j. aniline 72-79 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 24-30 4014668-1 1985 Simple and sensitive spectrophotometric and radiochemical procedures are described for the assay of acetyl-CoA:arylamine N-acetyltransferase (NAT; EC 2.3.1.5), which catalyzes the reaction acetyl-CoA + arylamine----N-acetylated arylamine + CoASH. aniline 111-120 bromodomain containing 2 Homo sapiens 142-145 3873242-6 1985 The results were interpreted as indicating that the distinct ethanol-inducible cytochrome P-450 isozyme, with a high specific activity toward aniline, undergoes a very rapid turnover in liver microsomes. aniline 142-149 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 79-95 4014668-3 1985 The spectrophotometric assay is characterized by two features: (i) NAT activity is measured by quantifying the disappearance of the arylamine substrate as reflected by decreasing Schiff"s base formation with dimethylaminobenzaldehyde. aniline 132-141 bromodomain containing 2 Homo sapiens 67-70 3158540-3 1985 The ability of nicotinamide and diethylnicotinamide to interact with cytochrome P-450 underlies their antagonism with respect to in-vitro metabolism of the substrates of both Type I (amidopyrine) and Type II (aniline) as well as with respect to the competition with CO for the common center of binding on the enzyme. aniline 209-216 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 69-85 2983185-2 1985 Reaction thermodynamics have been calculated for an oxene model for cytochrome P-450 oxidations of four related arylamines: aniline, p-hydroxyaniline, acetanilide, and acetaminophen, by both radical and nonradical mechanisms, using a semiempirical molecular orbital method (modified neglect of differential overlap). aniline 112-122 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-84 2983185-2 1985 Reaction thermodynamics have been calculated for an oxene model for cytochrome P-450 oxidations of four related arylamines: aniline, p-hydroxyaniline, acetanilide, and acetaminophen, by both radical and nonradical mechanisms, using a semiempirical molecular orbital method (modified neglect of differential overlap). aniline 124-131 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-84 2986860-6 1985 Myeloperoxidase and H2O2 also catalysed extensive binding of these arylamines to calf thymus DNA. aniline 67-77 myeloperoxidase Bos taurus 0-15 6485021-6 1984 The specific activity of cytochrome P-450 to hydroxylate aniline which is independent to the enzymic form of cytochrome P-450 was closely correlated with the viscosity status of the microsomal membrane. aniline 57-64 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 25-41 6517938-4 1984 The monkey P-450 was active in the mixed function oxidation of benzphetamine, aminopyrine, ethylmorphine, aniline and 7-ethoxycoumarin in the presence of rat liver NADPH-cytochrome P-450 reductase and DLPC. aniline 106-113 cytochrome p450 oxidoreductase Rattus norvegicus 164-196 6497392-1 1984 Antibodies to cytochrome P-450 isozyme 3a, the ethanol-inducible isozyme in rabbit liver, were used to determine the role of this enzyme in the microsomal oxidation of alcohols and the p-hydroxylation of aniline. aniline 204-211 cytochrome P450 2E1 Oryctolagus cuniculus 14-41 2983784-5 1985 The alkylating radical substrate analogs covalently bound to microsomal cytochrome P-450 in the vicinity of the active center, resulting in the inhibition of oxidation of type I and II substrates (e. g., aniline and naphthalene). aniline 204-211 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-88 3978021-9 1985 Coumarin 7-hydroxylase in human liver is inhibited by alpha-naphthoflavone, SKF 525A, metyrapone and aniline. aniline 101-108 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-22 2858384-2 1985 kg-1, twice a day for 7 days) reduced (p less than 0.05) the in vitro hepatic microsomal metabolism of ethylmorphine (EM) and hexobarbital (HB) by 59 and 33%; aniline (AN) metabolism and microsomal P-450 levels were unaltered but GH reduced (p less than 0.001) NADPH-cytochrome c reductase by 17%. aniline 159-166 gonadotropin releasing hormone receptor Rattus norvegicus 230-232 6439243-8 1984 The T1 data for the isolated subunits alpha 3+ and beta 3+4 would indicate that overall binding of aniline includes a component of direct aniline-heme ligation in each case. aniline 99-106 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 38-59 6439243-8 1984 The T1 data for the isolated subunits alpha 3+ and beta 3+4 would indicate that overall binding of aniline includes a component of direct aniline-heme ligation in each case. aniline 138-145 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 38-59 6485021-6 1984 The specific activity of cytochrome P-450 to hydroxylate aniline which is independent to the enzymic form of cytochrome P-450 was closely correlated with the viscosity status of the microsomal membrane. aniline 57-64 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 109-125 6548324-5 1984 This microsomal activity is probably mediated by cytochrome P-450 because the reduction is blocked by carbon monoxide and primary amines [aniline, n-octylamine, and 2,4-dichloro-6-phenylphenoxyethylamine (DPEA)]. aniline 138-145 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 49-65 6545996-1 1984 Short-term exposure of the control and phenobarbitone-treated rats to high ambient temperature caused a different response of the hepatic microsomal cytochrome P-450-dependent monooxygenase system participating in the oxidation of aniline, aminopyrine and p-nitroanisole. aniline 231-238 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 149-165 6466534-2 1984 In the present study RIF-1 clones have been exposed to nitrogen mustard, aniline mustard and chlorambucil, and to nitrosoureas BCNU, MeCCNU and chlorozotocin, in order to evaluate whether or not the different physiochemical and biological activities of these agents would affect the patterns of drug sensitivity obtained for melphalan and CCNU. aniline 73-80 replication timing regulatory factor 1 Mus musculus 21-26 6723577-11 1984 Difference spectral measurements using crude placental microsomes and cholate extracts of these microsomes show that binding of 4- cyclohexylaniline produces a type II spectral change; this is indicative of coordination of the arylamine to the heme-iron of the aromatase cytochrome P-450. aniline 227-236 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 282-287 6733159-1 1984 The effects of the phospholipid composition of rat liver microsomes on the differential binding spectra of cytochrome P-450 with type I and II substrates (hexobarbital and aniline) were studied. aniline 172-179 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 107-123 6611263-0 1984 Cytochrome P-450 metabolic-intermediate complex formation from p-aminobenzoic acid esters and other arylamines. aniline 100-110 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 6830852-3 1983 Caffeine addition (in vitro) to partially purified cytochrome P-450 altered the hexobarbital, aniline and ethylisocyanide induced spectral change, and decreased NADPH oxidation in presence of substrates aminopyrine and acetanilide. aniline 94-101 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 51-67 6661451-0 1983 [Comparative inhibitory analysis of aniline hydroxylation by cytochrome P-450 in NADPH-, hydroperoxide cumyl- and H2O2-dependent systems]. aniline 36-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 61-77 6622818-2 1983 Pretreatment of rats with 3,4-benzpyrene or phenobarbital increased the liver microsomal concentration of cytochrome P-450 (448) and the rate of aminopyrine and p-nitroanisole demethylation and of aniline hydroxylation whereas pretreatment cytochrome P-450 depressor agents such as cadmium or cobalt lowered the concentration of the hemoprotein and decreased the rate of the demethylation reactions. aniline 197-204 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 106-122 6609756-3 1984 Induction of aniline hydroxylase activity by ethanol was associated with marked increases in the turnover numbers of the more basic cytochrome P-450 containing fractions in a reconstituted aniline hydroxylation system. aniline 13-20 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 132-148 6696448-4 1984 Such a cytochrome b5-induced structural alteration of the reconstituted enzyme system is accompanied by an increase in affinity of 4-chloroaniline for cytochrome P-450, as measured in terms of cumene hydroperoxide-supported N-oxidation of the arylamine; the maximum velocity of the catalytic process remains unchanged. aniline 243-252 cytochrome b5 type A Homo sapiens 7-20 6696448-4 1984 Such a cytochrome b5-induced structural alteration of the reconstituted enzyme system is accompanied by an increase in affinity of 4-chloroaniline for cytochrome P-450, as measured in terms of cumene hydroperoxide-supported N-oxidation of the arylamine; the maximum velocity of the catalytic process remains unchanged. aniline 243-252 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 151-167 6416257-1 1983 Acetone stimulated NADPH-dependent aniline hydroxylation catalysed by cytochrome P-450 purified from phenobarbital-treated rats. aniline 35-42 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 70-86 6416257-3 1983 Cumene hydroperoxide-supported aniline hydroxylation catalysed by cytochrome P-450 was not increased by the addition of acetone at the concentration which stimulated NADPH-dependent aniline hydroxylation in the reconstituted system. aniline 31-38 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 66-82 6416257-3 1983 Cumene hydroperoxide-supported aniline hydroxylation catalysed by cytochrome P-450 was not increased by the addition of acetone at the concentration which stimulated NADPH-dependent aniline hydroxylation in the reconstituted system. aniline 182-189 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 66-82 6416257-4 1983 The NADPH-dependent cytochrome P-450 reduction was stimulated by acetone in the presence or absence of aniline. aniline 103-110 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 20-36 6888166-2 1983 The results indicate that the in vitro interaction of hexobarbital and SKF-525 A (type I binding compounds) with microsomal cytochrome p-450 inhibits the peroxidase activity while the in vitro interaction of aniline (type II binding compound) only slightly affect the peroxidase activity. aniline 208-215 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 124-140 6412716-3 1983 PCB P-448-H catalyzed the hydroxylation of aniline and O-dealkylations of p-alkoxy derivatives of aniline and nitrobenzene and 7-alkoxy derivatives of coumarin. aniline 43-50 pyruvate carboxylase Rattus norvegicus 0-3 6412716-3 1983 PCB P-448-H catalyzed the hydroxylation of aniline and O-dealkylations of p-alkoxy derivatives of aniline and nitrobenzene and 7-alkoxy derivatives of coumarin. aniline 43-50 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 4-9 6412716-3 1983 PCB P-448-H catalyzed the hydroxylation of aniline and O-dealkylations of p-alkoxy derivatives of aniline and nitrobenzene and 7-alkoxy derivatives of coumarin. aniline 98-105 pyruvate carboxylase Rattus norvegicus 0-3 6412716-3 1983 PCB P-448-H catalyzed the hydroxylation of aniline and O-dealkylations of p-alkoxy derivatives of aniline and nitrobenzene and 7-alkoxy derivatives of coumarin. aniline 98-105 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 4-9 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 48-55 pyruvate carboxylase Rattus norvegicus 128-131 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 48-55 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 132-139 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 48-55 pyruvate carboxylase Rattus norvegicus 165-168 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 48-55 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 132-137 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 48-55 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 207-223 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 48-55 pyruvate carboxylase Rattus norvegicus 165-168 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 102-109 pyruvate carboxylase Rattus norvegicus 128-131 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 102-109 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 132-139 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 102-109 pyruvate carboxylase Rattus norvegicus 165-168 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 102-109 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 132-137 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 102-109 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 207-223 6412716-4 1983 Among the activities measured, hydroxylation of aniline and O-dealkylation of p-alkoxy derivatives of aniline were catalyzed by PCB P-448-H more efficiently than by PCB P-448-L, which was a low spin form of cytochrome P-448 purified from liver microsomes of PCB-treated rats. aniline 102-109 pyruvate carboxylase Rattus norvegicus 165-168 7167977-2 1982 Treatment with Liv-52 (before or after CCl4 administration) markedly decreased, the CCl4-mediated reduction in aniline hydrochloride and p-aminopyrine N-demethylase activities, although the decrease in AHH activity could not be prevented. aniline 111-132 C-C motif chemokine ligand 4 Rattus norvegicus 84-88 6667340-6 1983 The present data suggest that the combination of aniline mustard glucuronide with glucose, could be effective in those tumours which have a high beta-glucuronidase activity and a lower tumour intracellular pH could be induced by glucose. aniline 49-56 beta-glucuronidase Bos taurus 145-163 7285242-8 1981 On the contrary, the absorbance magnitude between peak and trough in the aniline- or alcohol-induced difference spectrum of microsomes was enhanced by decreasing the pH, indicating easy complex formation of type II and reverse type I compounds with cytochrome P-450 in the acid rather than the alkaline region. aniline 73-80 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 249-265 7175744-1 1982 The activity of the pineal enzyme arylamine: N-acetyltransferase (NAT) was determined following direct stimulation of the preganglionic or post-ganglionic nerves of the superior cervical ganglia. aniline 34-43 N-acetyltransferase 1 Rattus norvegicus 45-64 7175744-1 1982 The activity of the pineal enzyme arylamine: N-acetyltransferase (NAT) was determined following direct stimulation of the preganglionic or post-ganglionic nerves of the superior cervical ganglia. aniline 34-43 N-acetyltransferase 1 Rattus norvegicus 66-69 6286157-1 1982 Cytochrome P-448 dependent microsomal N-hydroxylases are key enzymes in the metabolic activation of both arylamides and arylamines. aniline 120-130 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 0-16 7085677-7 1982 This cytochrome displays the highest activity of all of the rabbit isozymes in the oxidation of ethanol to acetaldehyde and the p-hydroxylation of aniline when reconstituted with NADPH-cytochrome P-450 reductase and phospholipid in the presence of NADPH and oxygen. aniline 147-154 NADPH--cytochrome P450 reductase Oryctolagus cuniculus 179-211 7085637-2 1982 Arylamine N-methyltransferase catalyzes the novel methylation of the ring nitrogen of tryptamine and pyrrole as well as a number of other arylamines including aniline and its derivatives. aniline 138-148 indolethylamine N-methyltransferase Homo sapiens 0-29 7085637-2 1982 Arylamine N-methyltransferase catalyzes the novel methylation of the ring nitrogen of tryptamine and pyrrole as well as a number of other arylamines including aniline and its derivatives. aniline 159-166 indolethylamine N-methyltransferase Homo sapiens 0-29 6811575-7 1982 In the reconstituted system containing cytochrome P-450 partially purified from p-nitroanisole- or NKK-105-treated rats, cytochrome b5 was required for the maximal activities of the demethylation reactions, but did not participate in aniline hydroxylation. aniline 234-241 cytochrome b5 type A Rattus norvegicus 121-134 6288047-4 1982 RJ inhibited the microsomal oxidation of substrates of cytochrome P-450 (aniline, aminopyrine and benzo [a]pyrene). aniline 73-80 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 55-71 6810958-1 1982 The low molecular weight analog of superoxide dismutase, th Cu(Lys)2 complex inhibits the oxidation of type I (piperidinoanthraquinone) and type II(aniline) substrates catalyzed by cytochrome P-450. aniline 148-155 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Homo sapiens 60-68 6810958-1 1982 The low molecular weight analog of superoxide dismutase, th Cu(Lys)2 complex inhibits the oxidation of type I (piperidinoanthraquinone) and type II(aniline) substrates catalyzed by cytochrome P-450. aniline 148-155 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 192-197 6285925-0 1982 Aniline is hydroxylated by the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism. aniline 0-7 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-47 7170869-1 1982 The interaction of highly purified cytochrome P-450 from bovine adrenal cortex mitochondria (cytochrome P-450scc) with N,N-dimethylaniline (DMA), aniline, N-dimethylcyclohexylamine and cumene hydroperoxide (CHP) has been investigated. aniline 131-138 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 93-112 7059462-2 1982 Experiments in rodent systems have demonstrated a marked anti-tumour effect of the drug aniline mustard (AM) on tumours with high levels of this enzyme (e.g. the plasmacytomas PC5 and PC6). aniline 88-95 proprotein convertase subtilisin/kexin type 5 Homo sapiens 176-179 7059462-2 1982 Experiments in rodent systems have demonstrated a marked anti-tumour effect of the drug aniline mustard (AM) on tumours with high levels of this enzyme (e.g. the plasmacytomas PC5 and PC6). aniline 88-95 proprotein convertase subtilisin/kexin type 5 Homo sapiens 184-187 7297957-1 1981 Hemoglobin and cytochrome P-450 have in common heme structure (i.e. protoporphyrin (IX), binding ability to molecular oxygen or carbon monoxide and enzyme-like activity (i.e. aniline hydroxylation; J.B.C. aniline 175-182 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-31 6788369-6 1981 The end product of aniline mustard metabolism, p-hydroxyaniline mustard O-glucuronide, may be more extensively activated by beta-glucuronidase in hormonally regressing than in growing or stationary tumors. aniline 19-26 glucuronidase, beta Rattus norvegicus 124-142 208787-0 1978 A model of cytochrome P-450; optical and EPR properties of a thiol-containing peptide-hemin system and its activity of aniline hydroxylation. aniline 119-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 11-27 7260191-2 1981 The results obtained suggest that the LM4 form of cytochrome P-450 is catalytically inactive during aniline oxidation and dimethylaniline demethylation in both cases. aniline 100-107 cytochrome P-450 Oryctolagus cuniculus 50-66 7260196-4 1981 The rates of cytochrome P-450 reduction and oxidation of dimethylaniline, aniline, p-nitroanisol and NAD(P)H, as well as those of oxygen uptake and lipid peroxidation do not depend on the bilayer viscosity. aniline 65-72 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 13-29 7413717-3 1980 Data suggest that enhancement of p-hydroxylation of aniline by acetone, malaoxon and paraoxon may result from inhibition of further metabolism of PAP by the microsomal cytochrome b5-dependent desaturase system. aniline 52-59 cytochrome b5 type A Homo sapiens 168-181 6086112-0 1980 [Effect of phospholipids on the activity of highly-purified liver microsome cytochrome P-450 in a reaction of aniline and naphthalene hydroxylation by hydroperoxides]. aniline 110-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-92 6272881-3 1981 In case of p-hydroxylation of aniline the inhibiting effect of the Cu-tyrosine complex is much more pronounced than its inactivating effect on cytochrome P-450. aniline 30-37 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 143-159 6272881-6 1981 In a soluble system containing isolated cytochrome P-450 and cumole hydroperoxide only the aniline p-hydroxylation reaction was found sensitive to the effect of superoxide dismutase. aniline 91-98 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56 6786276-1 1980 Apparent kinetic constant (NADPH) have been calculated for NADPH-cytochrome P450 reductase and parahydroxylase in the presence of aniline with hepatic microsomes from both phenobarbital pre-treated and untreated rats. aniline 130-137 cytochrome p450 oxidoreductase Rattus norvegicus 59-90 6786276-2 1980 The addition of NADH gave similar stimulation of both aniline parahydroxylation and NADPH-cytochrome P450 reductase activity in the presence of aniline. aniline 144-151 cytochrome p450 oxidoreductase Rattus norvegicus 84-115 6786276-3 1980 It is proposed that the increase in aniline metabolism with NADH is due to an increase in the NADPH-cytochrome P450 reductase activity which is rate limiting in microsomes from both phenobarbital and untreated rats. aniline 36-43 cytochrome p450 oxidoreductase Rattus norvegicus 94-125 7428105-1 1980 The in vitro inhibitor of mixed-function oxidation, 9-hydroxyellipticine, non-competitively inhibited the binding of the type II substrate, aniline, to cytochrome P-448 of hepatic microsomal preparations from rats pretreated with 3-methylcholanthrene. aniline 140-147 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 152-168 6252201-11 1980 Benzphetamine and aniline, added to oxidized P-450(1), cause Type I and Type II spectral changes, respectively, but the magnitudes of the changes are small in both cases. aniline 18-25 cytochrome P450 2C5 Oryctolagus cuniculus 45-53 7390998-9 1980 Reconstruction experiments using purified NADPH-cytochrome P-450 reductase and cytochrome P-450 were also carried out and it was confirmed that the reduction of nitrobenzene, nitrosobenzene, and phenylhydroxylamine to aniline could be effected by these two components. aniline 218-225 cytochrome p450 oxidoreductase Rattus norvegicus 42-74 7390998-9 1980 Reconstruction experiments using purified NADPH-cytochrome P-450 reductase and cytochrome P-450 were also carried out and it was confirmed that the reduction of nitrobenzene, nitrosobenzene, and phenylhydroxylamine to aniline could be effected by these two components. aniline 218-225 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 48-64 7390998-13 1980 Cytochrome P-450 is essential at least in the final step of nitrobenzene reduction to aniline. aniline 86-93 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 7384010-2 1980 The effect of the degree of albumin modification of the matrix on the catalytic activity of immobolized cytochrome P-450 has been studied in cumene hydroperoxide dependent aniline hydroxylation. aniline 172-179 cytochrome P-450 Oryctolagus cuniculus 104-120 7370330-1 1980 Thermal inactivation of cytochrome P-450 in different states (microsomes, highly purified and immobilized), characterized by the loss of catalytic activity in cumene hydroperoxide--dependent aniline hydroxylation has been studied in the temperature range 40-58 degrees C. The process of thermoinactivation is characterized by the first order rate constants. aniline 191-198 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-40 7227217-4 1980 The drug binding of either aniline or pentobarbital to cytochrome P-450 was also decreased. aniline 27-34 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 55-71 7227217-8 1980 This finding was further substantiated by the increase in pentobarbital and aniline binding to cytochrome P-450. aniline 76-83 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 95-111 519812-0 1979 A model system of cytochrome P-450: hydroxylation of aniline by iron- or hemin-thiol compound systems. aniline 53-60 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-34 229676-1 1979 The Cu(Lys)2 complex is shown to be an effective inhibitor of the oxidation of 3,4-benzpyrene and aniline in microsomes. aniline 98-105 aminoadipate-semialdehyde dehydrogenase Homo sapiens 4-12 517003-4 1979 Liposome-bound cytochrome P-450 has a higher dimethylaniline, aniline and p-nitroanisole hydroxylase activity than its soluble form. aniline 53-60 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-31 517012-4 1979 The acidic phospholipids, phosphatidylserine and phosphatidylinositol and total microsomal phospholipids containing the acidic lipid components activate cytochrome P-450 in the hydroxylation of aniline and naphthalene by CHP. aniline 194-201 cytochrome P-450 Oryctolagus cuniculus 153-169 743228-1 1978 Aniline azopigments B4, B5 and B6, derived from conjugates of bilirubin-IX alpha in human bile, and previously characterized as disaccharidic esters [Kuenzle (1970) Biochem. aniline 0-7 CD19 molecule Homo sapiens 20-33 32922-0 1978 [Spectral parameters of the cytochrome c and hemoglobin interaction with methanol and aniline]. aniline 86-93 cytochrome c, somatic Homo sapiens 28-40 32922-1 1978 At 20 degrees C, in a phosphate buffer, pH 5,8--8,0, methanol and aniline interactions with hemoglobin and cytochrome c were studied using the difference spectrophotometry method. aniline 66-73 cytochrome c, somatic Homo sapiens 107-119 722999-0 1978 Glutathione depletion by aniline analogs in vitro associated with liver microsomal cytochrome P-450. aniline 25-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 83-99 722999-1 1978 Enzymic depletion of glutathione (GSH) in vitro by aniline analogs was mostly dependent on the cytochrome P-450 level in liver microsomes. aniline 51-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 95-111 19154-0 1977 The nature of the rate-limiting step in aniline hydroxylation involving cytochrome p-450 rat liver microsomes. aniline 40-47 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 72-88 205493-2 1978 The difference spectrum of methemoglobin induced by aniline or aminopyrine was similar to type II, and that of oxidized cytochrome c induced by aniline was similar to type I. aniline 52-59 hemoglobin subunit gamma 2 Homo sapiens 27-40 205493-2 1978 The difference spectrum of methemoglobin induced by aniline or aminopyrine was similar to type II, and that of oxidized cytochrome c induced by aniline was similar to type I. aniline 144-151 cytochrome c, somatic Homo sapiens 120-132 205493-6 1978 Each of the reduced forms of hemoglobin or reduced cytochrome c showed a higher affinity to aminopyrine than to aniline. aniline 112-119 cytochrome c, somatic Homo sapiens 51-63 597513-2 1977 The reactions were characterized by the values of the aniline oxidation rate constants, k2=v/[E]0, where [E]0 is the initial concentration of cytochrome P--450: k1 2=1,60.10(8) exp (--13400/RT) sec-1., k2 2=1,66.10(9) exp (--14500/RT) sec-1., k3 2=6,83.10(9) exp (--15300/RT) sec-1. aniline 54-61 secretory blood group 1 Rattus norvegicus 194-199 597513-2 1977 The reactions were characterized by the values of the aniline oxidation rate constants, k2=v/[E]0, where [E]0 is the initial concentration of cytochrome P--450: k1 2=1,60.10(8) exp (--13400/RT) sec-1., k2 2=1,66.10(9) exp (--14500/RT) sec-1., k3 2=6,83.10(9) exp (--15300/RT) sec-1. aniline 54-61 secretory blood group 1 Rattus norvegicus 235-240 597513-2 1977 The reactions were characterized by the values of the aniline oxidation rate constants, k2=v/[E]0, where [E]0 is the initial concentration of cytochrome P--450: k1 2=1,60.10(8) exp (--13400/RT) sec-1., k2 2=1,66.10(9) exp (--14500/RT) sec-1., k3 2=6,83.10(9) exp (--15300/RT) sec-1. aniline 54-61 secretory blood group 1 Rattus norvegicus 235-240 19154-4 1977 The nature of aniline binding to cytochrome P-450 and that of the hydroxylating agent have been discussed. aniline 14-21 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 33-49 883972-0 1977 Kinetics of cumene hydroperoxide-dependent aniline hydroxylation involving cytochrome P-450 in microsomal and solubilized forms. aniline 43-50 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 86-91 931994-2 1976 Human hemoglobin was characterized as an enzyme in a reconstituted aniline hydroxylase system containing hemoglobin, NADPH, rat liver cytochrome P-450 reductase, aniline and atmospheric O2. aniline 67-74 cytochrome p450 oxidoreductase Rattus norvegicus 134-160 12746-5 1976 In the presence of 0.03-0.09% sodium deoxycholate the rate-limiting factor in p-hydroxylation of aniline is the content of cytochrome P-450. aniline 97-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 123-139 183127-0 1976 Inactivation of parathyroid hormone mRNA by treatment with periodate and aniline. aniline 73-80 parathyroid hormone Homo sapiens 16-35 956135-2 1976 During reduction of aniline and azide complexes with cytochrome P-450, an intermediate spectrum developed in the fast phase and changed to that of the reduced form in the slow phase. aniline 20-27 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-69 956135-7 1976 These results indicate that reduction of the aniline and azide complexes of cytochrome P-450 involves two steps: first reduction of cytochrome P-450 and then some changes in reduced state. aniline 45-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-92 956135-7 1976 These results indicate that reduction of the aniline and azide complexes of cytochrome P-450 involves two steps: first reduction of cytochrome P-450 and then some changes in reduced state. aniline 45-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 132-148 956135-8 1976 The aniline and cyanide difference spectra of reduced cytochrome P-450 showed peaks at 423 nm and 429 nm, respectively, while that of azide had a peak at 445 nm and a trough at 404 nm. aniline 4-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 54-70 1259750-0 1976 The cooperative interaction of aniline with methemoglobin. aniline 31-38 hemoglobin subunit gamma 2 Homo sapiens 44-57 983613-0 1976 The binding of hexobarbital and aniline to cytochrome P-450 of liver microsomes from control and phenobarbital-treated rats of different ages. aniline 32-39 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 43-59 983613-1 1976 The spectral changes due to the binding of hexobarbital and aniline to cytochrome P-450 of rat liver microsomes were investigated in 10-day- to 15-month-old rats. aniline 60-67 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 71-87 1032243-2 1976 A moderate increase was found in the amount of microsomal protein and cytochrome P 450, a marked increase in the metabolism of both aminopyrine (substrate of type I) and aniline (substrate of type II), together with an increase in the butylisocyanide-absorption maxima of both haemoproteins involved in the reaction. aniline 170-177 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 70-86 1246040-1 1976 The effect of aromatic nitro compounds on the oxidative metabolism of representative type I (hexobarbital and aminopyrene) and type II (aniline and zoxazolamine) substrates by cytochrome P-450 dependent liver enzymes was studied. aniline 136-143 cytochrome P-450 Oryctolagus cuniculus 176-192 934354-3 1976 The aniline, after acetylation, was identified as acetanilide by melting point, Rf-value in TCL as well as UV, IR, and NMR spectroscopy. aniline 4-11 ras homolog family member J Homo sapiens 92-95 822434-3 1976 Binding of aniline to microsomes from rats fed high levels of thiamin is decreased due to a decrease in cytochrome P-450. aniline 11-18 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 104-120 173534-9 1975 A second effect of aniline, a type II ligand of cytochrome P-450, was to remove the g = 6 signal, suggesting that it also interacts with cytochrome P-420. aniline 19-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-64 1201750-3 1975 On the basis of binding studies with ethyl isocyanide, degradation of cytochrome P-450 to P-420, redox potential, aniline binding, and relative rates of reduction by NADPH and NADH, it is suggested that the cytochrome P-450 system is analogous to that mammalian microsomes. aniline 114-121 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 207-223 1131251-0 1975 Purification of cytochrome P-450 from bovin adrenocortical mitochondria by an "aniline-sepharose" and the properties. aniline 79-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 16-32 168750-9 1975 The reconstituted enzyme system containing purified cytochrome P-450, purified NADPH-cytochrome P-450 reductase, and phosphatidylcholine retains the ability to catalyze the hydroxylation of drugs, fatty acids, hydrocarbons, and aniline in the presence of NADPH and molecular oxygen. aniline 228-235 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 52-68 168750-9 1975 The reconstituted enzyme system containing purified cytochrome P-450, purified NADPH-cytochrome P-450 reductase, and phosphatidylcholine retains the ability to catalyze the hydroxylation of drugs, fatty acids, hydrocarbons, and aniline in the presence of NADPH and molecular oxygen. aniline 228-235 cytochrome p450 oxidoreductase Rattus norvegicus 79-111 33949438-3 2021 The mechanisms for the formation of 1,4-DHP and 1,2-DHP were proposed based on the isolated intermediate named diethyl 4-((phenylamino)methylene)pent-2-enedioate generated by the Michael addition of aniline and ethyl propiolate. aniline 199-206 dihydropyrimidinase Homo sapiens 40-43 5615639-0 1967 [On the methemoglobin-forming ability of isopropylnitrate, metaxylidine and aniline]. aniline 76-83 hemoglobin subunit gamma 2 Homo sapiens 8-21 13961266-0 1963 [Methemoglobin poisonings by diapers stamped with fresh aniline dyes]. aniline 56-63 hemoglobin subunit gamma 2 Homo sapiens 1-14 12982321-0 1952 [Relation of methemoglobinemia to catalase in experimental aniline poisoning]. aniline 59-66 catalase Homo sapiens 34-42 14953219-0 1952 [Effects of the substitution of aniline by the methyl group on the formation of hemoglobin (methemoglobin) and the general toxicity of the compound]. aniline 32-39 hemoglobin subunit gamma 2 Homo sapiens 92-105 33831395-1 2021 Human NAT2 is a polymorphic pharmacogene encoding for N-acetyltransferase 2, a hepatic enzyme active towards arylamine and arylhydrazine drugs, including the anti-tubercular antibiotic isoniazid. aniline 109-118 N-acetyltransferase 2 Macaca mulatta 6-10 5568572-0 1971 Aniline derivatives as substrates for ceruloplasmin. aniline 0-7 ceruloplasmin Homo sapiens 38-51 5451632-0 1970 Method for in vitro determination of methemoglobin production induced by aniline derivatives. aniline 73-80 hemoglobin subunit gamma 2 Homo sapiens 37-50 34039986-3 2021 Herein, using a wet-chemical method, we successfully achieved a mesoporous graphitic carbon nitride (mpg-C3N4) supported dual-atom Pt2 catalyst, which exhibited excellent catalytic performance for the highly selective hydrogenation of nitrobenzene to aniline. aniline 251-258 N-methylpurine DNA glycosylase Homo sapiens 101-104 33949438-3 2021 The mechanisms for the formation of 1,4-DHP and 1,2-DHP were proposed based on the isolated intermediate named diethyl 4-((phenylamino)methylene)pent-2-enedioate generated by the Michael addition of aniline and ethyl propiolate. aniline 199-206 dihydropyrimidinase Homo sapiens 52-55 33619857-1 2021 Gut microorganisms metabolize azobenzene compounds (Ph1-N=N-Ph2) into free aniline products (Ph1-NH2 + H2N-Ph2), a process that has been largely investigated to reduce dyes residues in the textile industry. aniline 75-82 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 52-55 33397596-5 2021 Optimal quantitative sensing of miR-141 was achieved via the first example of an electrochemical oligonucleotide-templated reaction (EOTR), whereby two PNA probes - functionalized with an aniline and a 1,4-catechol respectively - preferentially react with each other upon simultaneous hybridization to the same RNA target strand, serving here as a template. aniline 188-195 microRNA 141 Homo sapiens 32-39 33550182-5 2021 Molecular docking suggested that 6u formed direct hydrogen bond interactions with Ser75 and Gln61 in PDK1, and meanwhile the aniline skeleton in 6u was sandwiched by the conserved hydrophobic residues Phe78 and Phe65, which contribute to the biochemical activity improvement. aniline 125-132 pyruvate dehydrogenase kinase 1 Homo sapiens 101-105 33360139-8 2021 However, TOC indicated that aniline was not completely mineralized in the process. aniline 28-35 rhomboid 5 homolog 2 Homo sapiens 9-12 33619857-1 2021 Gut microorganisms metabolize azobenzene compounds (Ph1-N=N-Ph2) into free aniline products (Ph1-NH2 + H2N-Ph2), a process that has been largely investigated to reduce dyes residues in the textile industry. aniline 75-82 polyhomeotic homolog 2 Homo sapiens 60-63 33619857-1 2021 Gut microorganisms metabolize azobenzene compounds (Ph1-N=N-Ph2) into free aniline products (Ph1-NH2 + H2N-Ph2), a process that has been largely investigated to reduce dyes residues in the textile industry. aniline 75-82 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 93-96 33619857-1 2021 Gut microorganisms metabolize azobenzene compounds (Ph1-N=N-Ph2) into free aniline products (Ph1-NH2 + H2N-Ph2), a process that has been largely investigated to reduce dyes residues in the textile industry. aniline 75-82 polyhomeotic homolog 2 Homo sapiens 107-110 33665266-7 2021 However, the results of electrolytes sodium-potassium tartrate (Na-K tartrate) and benzoic acid in alcohol-water (BAW) are reported for the polymerization of aniline onto MS [11]. aniline 158-165 TANK binding kinase 1 Homo sapiens 64-68 33444019-0 2021 Reactivity Trends in the Gas-Phase Addition of Acetylene to the N-Protonated Aryl Radical Cations of Pyridine, Aniline, and Benzonitrile. aniline 111-118 gastrin Homo sapiens 25-28 33348591-5 2020 The possibility of fused isoxazoles synthesis via the intramolecular nucleophilic substitution of a protonated NMe2 group in the aniline and naphthalene series is predicted. aniline 129-136 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 111-115 33537010-2 2020 Arylamine N-acetyltransferases (NAT, E.C. aniline 0-9 bromodomain containing 2 Homo sapiens 32-35 33537010-4 2020 In this research, to evaluate the effect of NAT on acetyl group transformation in arylamine antibiotics, we first used sequence alignment to study the structure of V. vulnificus NAT [(VIBVN)NAT]. aniline 82-91 bromodomain containing 2 Homo sapiens 44-47 33537010-4 2020 In this research, to evaluate the effect of NAT on acetyl group transformation in arylamine antibiotics, we first used sequence alignment to study the structure of V. vulnificus NAT [(VIBVN)NAT]. aniline 82-91 bromodomain containing 2 Homo sapiens 178-181 33537010-4 2020 In this research, to evaluate the effect of NAT on acetyl group transformation in arylamine antibiotics, we first used sequence alignment to study the structure of V. vulnificus NAT [(VIBVN)NAT]. aniline 82-91 bromodomain containing 2 Homo sapiens 178-181 33537010-13 2020 These results showed that (VIBVN)NAT could acetylate various aromatic amine substrates and contribute to arylamine antibiotic resistance in V. vulnificus. aniline 105-114 bromodomain containing 2 Homo sapiens 33-36 33451036-2 2021 The sensor was based on a carbon paste electrode (CPE) modified with electroactive polyimide (EPI) synthesized using aniline tetramer (ACAT) decorated with reduced nanoparticles (NPs) of Au, Pt, and Ag. aniline 117-124 sterol O-acyltransferase 1 Homo sapiens 135-139 33074119-1 2020 Herein, we report the synthesis of novel 2-substituted styrylquinazolines conjugated with aniline or sulfonamide moieties, anticipated to act as potent anticancer therapeutic agents through preferential EGFR inhibition. aniline 90-97 epidermal growth factor receptor Homo sapiens 203-207 31910058-1 2020 Reducted arylamine N-acetyltransferase (NAT1) in breast cancers is associated with poor patient survival. aniline 9-18 N-acetyltransferase 1 Homo sapiens 40-44 33083237-1 2020 Recent reports suggest that arylamine N-acetyltransferases (NAT1 and/or NAT2) serve important roles in regulation of energy utility and insulin sensitivity. aniline 28-37 N-acetyltransferase 1 Rattus norvegicus 60-64 32972253-4 2020 Docking studies suggested that the formation of a salt bridge between the nitrogen of the aniline moiety with ASP678 of the Mer kinase domain as well as an interaction with the hinge region that most kinase inhibitors have in common would be essential to retain activity. aniline 90-97 MER proto-oncogene, tyrosine kinase Homo sapiens 124-127 33074312-5 2020 Our hydrochloric acid/aniline assay revealed that the karyopherin Mtr10 mediates retrograde import of tRNAPhe, constitutively and in response to amino acid deprivation, whereas the Hsp70 protein Ssa2 mediates import specifically in the latter. aniline 22-29 Mtr10p Saccharomyces cerevisiae S288C 66-71 32521073-2 2020 This synthetic approach is used here to gradually transform a new bimetallic MOF, composed of Pd and Fe as metal components, via the in situ generation of aniline under mild conditions. aniline 155-162 lysine acetyltransferase 8 Homo sapiens 77-80 32843329-5 2020 Rat liver tritosomes and cathepsin B yielded IGN-P1 aniline, sulfonated IGN-P1 (s-IGN-P1) aniline and a lysine conjugate of IGN-P1 (IGN-P1-Lys) aniline as catabolites. aniline 52-59 cathepsin B Rattus norvegicus 25-36 33083237-1 2020 Recent reports suggest that arylamine N-acetyltransferases (NAT1 and/or NAT2) serve important roles in regulation of energy utility and insulin sensitivity. aniline 28-37 N-acetyltransferase 2 Rattus norvegicus 72-76 32971766-0 2020 Preparation of PP-g-(AA-MAH) Fibers Using Suspension Grafting and Melt-Blown Spinning and its Adsorption for Aniline. aniline 109-116 serglycin Homo sapiens 15-19 33533423-2 2020 Compounds 4-carboxy benzylidene-4-X-aniline (X = H, F, Cl, Br, CH3, OCH3) 1a-6a were synthesized by the reaction of aniline and its substituted derivatives with 4-formylbenzoic acid. aniline 36-43 chromosome 12 open reading frame 73 Homo sapiens 59-61 31816129-0 2020 Eosin Y-catalyzed photo-induced direct C(sp2)-H bond azo coupling of imidazo-heteroarenes and anilines with aryl diazonium salts. aniline 94-102 Sp2 transcription factor Homo sapiens 39-44 32497306-0 2020 Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2. aniline 57-66 N-acetyltransferase 2 Homo sapiens 87-91 32497306-2 2020 NAT2 has previously been classified as an arylamine N-acetyltransferase that mainly converts aromatic amines, hydroxylamines and hydrazines. aniline 42-51 N-acetyltransferase 2 Homo sapiens 0-4 32212372-4 2020 The chemical interaction between the acidic CO 2 molecule and the basic amino group of aniline renders enhanced CO 2 separation from O 2 . aniline 87-94 complement C2 Homo sapiens 44-48 32212372-4 2020 The chemical interaction between the acidic CO 2 molecule and the basic amino group of aniline renders enhanced CO 2 separation from O 2 . aniline 87-94 complement C2 Homo sapiens 112-116 32555504-1 2020 Human arylamine N-acetyltransferase 1 (NAT1), present in all tissues, is classically described as a phase-II xenobiotic metabolizing enzyme but can also catalyze the hydrolysis of acetyl-Coenzyme A (acetyl-CoA) in the absence of an arylamine substrate using folate as a cofactor. aniline 6-15 N-acetyltransferase 1 Homo sapiens 39-43 32429662-3 2020 Crucially, docking studies demonstrated that the m-chlorine-substituted aniline fragment occupied a hydrophobic subpocket enclosed by side chains of Val191, Tyr194, Val270, and Lys273, which creatively identify a new key anchoring point for the development of new MAGL inhibitors. aniline 72-79 monoglyceride lipase Homo sapiens 264-268 32423674-4 2020 of aniline-modified GOx was 20 x 10-2 min-1, or 3.7 times smaller than for the native GOx, while the kinact for benzoate-modified GOx was 26 x 10-2 min-1, or 2.8 times smaller than for the native GOx at the same temperature. aniline 3-10 hydroxyacid oxidase 1 Homo sapiens 20-23 32423674-4 2020 of aniline-modified GOx was 20 x 10-2 min-1, or 3.7 times smaller than for the native GOx, while the kinact for benzoate-modified GOx was 26 x 10-2 min-1, or 2.8 times smaller than for the native GOx at the same temperature. aniline 3-10 hydroxyacid oxidase 1 Homo sapiens 86-89 32423674-4 2020 of aniline-modified GOx was 20 x 10-2 min-1, or 3.7 times smaller than for the native GOx, while the kinact for benzoate-modified GOx was 26 x 10-2 min-1, or 2.8 times smaller than for the native GOx at the same temperature. aniline 3-10 hydroxyacid oxidase 1 Homo sapiens 86-89 32423674-4 2020 of aniline-modified GOx was 20 x 10-2 min-1, or 3.7 times smaller than for the native GOx, while the kinact for benzoate-modified GOx was 26 x 10-2 min-1, or 2.8 times smaller than for the native GOx at the same temperature. aniline 3-10 hydroxyacid oxidase 1 Homo sapiens 86-89 32423674-5 2020 Furthermore, at 240 MPa and 80.0 C, the kinact of the aniline-modified GOx was 69 times smaller than the kinact of native GOx (1530 x 10-2 min-1) at 0.1 MPa and 80.0 C. Similar results were obtained for benzoate-modified GOx. aniline 55-62 hydroxyacid oxidase 1 Homo sapiens 72-75 32423674-5 2020 Furthermore, at 240 MPa and 80.0 C, the kinact of the aniline-modified GOx was 69 times smaller than the kinact of native GOx (1530 x 10-2 min-1) at 0.1 MPa and 80.0 C. Similar results were obtained for benzoate-modified GOx. aniline 55-62 hydroxyacid oxidase 1 Homo sapiens 123-126 32423674-5 2020 Furthermore, at 240 MPa and 80.0 C, the kinact of the aniline-modified GOx was 69 times smaller than the kinact of native GOx (1530 x 10-2 min-1) at 0.1 MPa and 80.0 C. Similar results were obtained for benzoate-modified GOx. aniline 55-62 hydroxyacid oxidase 1 Homo sapiens 123-126 32423674-6 2020 At each temperature in this study (25-69.1 C), the catalytic activity of the native, aniline-, or benzoate-modified GOx increased with HHP, and reached a maximum at around 180 MPa. aniline 86-93 hydroxyacid oxidase 1 Homo sapiens 117-120 32423674-7 2020 At 180 MPa and 69.1 C, aniline-modified GOx produced the fastest catalytic rate, followed by benzoate-modified GOx, and then native GOx. aniline 24-31 hydroxyacid oxidase 1 Homo sapiens 41-44 32423674-7 2020 At 180 MPa and 69.1 C, aniline-modified GOx produced the fastest catalytic rate, followed by benzoate-modified GOx, and then native GOx. aniline 24-31 hydroxyacid oxidase 1 Homo sapiens 112-115 32423674-7 2020 At 180 MPa and 69.1 C, aniline-modified GOx produced the fastest catalytic rate, followed by benzoate-modified GOx, and then native GOx. aniline 24-31 hydroxyacid oxidase 1 Homo sapiens 112-115 32293634-1 2020 An I2-mediated synthesis of phenanthridines via intramolecular sp3 C-H amination of readily accessible aniline precursors is reported. aniline 103-110 Sp3 transcription factor Homo sapiens 63-66 31895247-12 2020 These results suggest refinement of the exposure limit and safety for arylamine carcinogens according to NAT2 genotype. aniline 70-79 N-acetyltransferase 2 Homo sapiens 105-109 31594345-1 2019 We report experimental observations of aniline (A) cations and He2 + when aniline is doped into ionized helium droplets. aniline 74-81 sperm associated antigen 11A Homo sapiens 63-66 32129076-0 2020 Cu(II)-Catalyzed Ortho C(sp2)-H Diarylamination of Arylamines To Synthesize Triarylamines. aniline 51-61 Sp2 transcription factor Homo sapiens 0-28 30873875-5 2019 Second, surface oxidative graft copolymerization of aniline was accomplished using the -NH2 moieties on the Fe3O4/PSt-NH2 as the anchoring sites. aniline 52-59 sulfotransferase family 1A member 1 Homo sapiens 114-117 31520338-2 2019 Protonated aniline prototropic tautomerization and nucleophilic substitution (SN1) to produce phenol with traces of water in the IMMS cell are reported. aniline 11-18 solute carrier family 38 member 3 Homo sapiens 78-81 31580376-1 2019 We reported a new method that visible light along with cercosporin, one of the naturally occurring perylenequinonoid pigments with excellent properties of photosensitization, photocatalyzed sp3 (C-H) activation for the synthesis of pyrrolo[3,4-c]quinolones through the annulation of anilines and maleimides under mild conditions. aniline 283-291 Sp3 transcription factor Homo sapiens 190-193 31871760-1 2019 The title compound, C14H12BrNO2, was synthesized by the condensation reaction of 2,3-di-hydroxy-benzaldehyde and 2-bromo-3-methyl-aniline. aniline 113-137 NLR family pyrin domain containing 12 Homo sapiens 20-31 31603317-8 2019 The reactive oxidants produced at 30 mA (or 60 mA/L) could degrade about 47% of 10 muM aniline and 34% of sulfanilamide within 6 h of Fe EC treatment. aniline 87-94 myelin and lymphocyte protein, T cell differentiation protein Mus musculus 47-51 31603317-8 2019 The reactive oxidants produced at 30 mA (or 60 mA/L) could degrade about 47% of 10 muM aniline and 34% of sulfanilamide within 6 h of Fe EC treatment. aniline 87-94 latexin Homo sapiens 83-86 31594345-3 2019 When aniline encounters the charged droplets, some are ionized via charge transfer, while others can remain neutral in the presence of He2 + when the mass-to-charge ratio (m/z) of the droplet is sufficiently large. aniline 5-12 sperm associated antigen 11A Homo sapiens 135-138 31483622-7 2019 Three QSAR models were developed, which were capable of predicting the reaction rate constants of Cl2 - with TrOCs bearing phenol, alkoxy benzene, and aniline groups. aniline 151-158 endogenous retrovirus group W member 5 Homo sapiens 98-101 31184191-0 2019 Copper-Catalyzed Electrophilic Ortho C(sp2)-H Amination of Aryl Amines: Dramatic Reactivity of Bicyclic System. aniline 59-70 Sp2 transcription factor Homo sapiens 37-42 31254350-1 2019 OBJECTIVE: N-Acetyltransferase 2 (NAT2) is a phase II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines and aromatic amines. aniline 130-140 N-acetyltransferase 2 Homo sapiens 11-32 31254350-1 2019 OBJECTIVE: N-Acetyltransferase 2 (NAT2) is a phase II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines and aromatic amines. aniline 130-140 N-acetyltransferase 2 Homo sapiens 34-38 31358821-1 2019 Human NAT1 gene for N-acetyltransferase 1 modulates xenobiotic metabolism of arylamine drugs and mutagens. aniline 77-86 N-acetyltransferase 1 Homo sapiens 6-10 31358821-1 2019 Human NAT1 gene for N-acetyltransferase 1 modulates xenobiotic metabolism of arylamine drugs and mutagens. aniline 77-86 N-acetyltransferase 1 Homo sapiens 20-41 31460023-2 2019 Capitalizing on the condensation reaction approach, the desired products were formed using a mixture of p-phenylendiamine and aniline with BCl3, followed by the addition of an aryl lithium derivative. aniline 126-133 BCL3 transcription coactivator Homo sapiens 139-143 31137814-5 2019 When the position of cinnamic acid moiety was placed at 4" carbon of aniline ring, PPARgamma agonist activity was completely abolished. aniline 69-76 peroxisome proliferator activated receptor gamma Homo sapiens 83-92 30085361-2 2019 The monodisperse PIL microspheres are first prepared via dispersion polymerization and then PANI is coated via low-temperature interfacial polymerization of aniline on the surface of hydrophobic PIL microspheres without additional modification. aniline 157-164 serpin family A member 2 (gene/pseudogene) Homo sapiens 17-20 30085361-2 2019 The monodisperse PIL microspheres are first prepared via dispersion polymerization and then PANI is coated via low-temperature interfacial polymerization of aniline on the surface of hydrophobic PIL microspheres without additional modification. aniline 157-164 serpin family A member 2 (gene/pseudogene) Homo sapiens 195-198 31649828-4 2019 In the case of aniline coupling reactions employing DBU, the resting state was a DBU-bound oxidative addition complex, LPd(DBU)(Ar)X, and the reaction was found to be inhibited by base. aniline 15-22 acyl-CoA synthetase bubblegum family member 1 Homo sapiens 119-122 30784748-3 2019 After 12 min with DBD plasma treatment, 90.2% removal efficiency was achieved at aniline concentration of 100 mg L-1 with an applied voltage of 3.0 kV and pH 8.43. aniline 81-88 immunoglobulin kappa variable 1-16 Homo sapiens 113-116 30562660-0 2019 Efficient removal of aniline by micro-scale zinc-copper (mZn/Cu) bimetallic particles in acidic solution: An oxidation degradation mechanism via radicals. aniline 21-28 mitochondrial calcium uniporter Mus musculus 61-63 31133770-5 2019 Overall, these studies demonstrate that proximal ligand substitution provides a promising strategy to tune the reactivity of myoglobin-based carbene and nitrene transfer catalysts and provide a first, proof-of-principle demonstration of the viability of pyridine-, thiophene-, and aniline-based unnatural amino acids for metalloprotein engineering. aniline 281-288 myoglobin Homo sapiens 125-134 30754020-3 2019 With the dosage of 0.5 g L-1 ZVI and 2 mM H2O2, aniline, Sb and Cr can be removed completely at pH 3. aniline 48-55 immunoglobulin kappa variable 3-15 Homo sapiens 25-38 30562660-1 2019 Micro-scale zinc-copper (mZn/Cu) bimetallic particles were prepared via precipitating Cu on the surface of Zn and were for the first time applied in the aniline degradation. aniline 153-160 mitochondrial calcium uniporter Mus musculus 29-31 30562660-1 2019 Micro-scale zinc-copper (mZn/Cu) bimetallic particles were prepared via precipitating Cu on the surface of Zn and were for the first time applied in the aniline degradation. aniline 153-160 mitochondrial calcium uniporter Mus musculus 86-88 30562660-2 2019 The results showed that the degradation efficiency of aniline was greatly related to the theoretical Cu mass loading and the initial pH. aniline 54-61 mitochondrial calcium uniporter Mus musculus 101-103 30562660-3 2019 The optimal Cu loading and initial pH for the destruction of aniline were determined as 60.45 wt% and 3, respectively. aniline 61-68 mitochondrial calcium uniporter Mus musculus 12-14 30562660-5 2019 The degradation of aniline by mZn, mCu, and mZn + mCu was <5% within 75 min. aniline 19-26 mitochondrial calcium uniporter Mus musculus 35-38 30562660-5 2019 The degradation of aniline by mZn, mCu, and mZn + mCu was <5% within 75 min. aniline 19-26 mitochondrial calcium uniporter Mus musculus 50-53 30562660-6 2019 However, 97% of aniline (10 mg L-1) was decomposed and 47% of TOC was removed by mZn/Cu, both of which were more than three times as much as those by mFe/Cu. aniline 16-23 immunoglobulin kappa variable 1-16 Homo sapiens 31-34 30562660-9 2019 Our findings suggested that mZn/Cu is a potential approach for aniline removal, which is different from the other bimetallic systems reported in the previous studies mainly as the reductive degradation. aniline 63-70 mitochondrial calcium uniporter Mus musculus 32-34 30525603-2 2019 Initial studies of androgen receptor (AR) antagonist (1) and agonist (2) propanamides yielded a tertiary aniline (3) with novel SARD activity but poor metabolic stability. aniline 105-112 androgen receptor Homo sapiens 19-36 31459398-6 2019 The ASC composed of aniline tetramer/WDG sheet exhibited high areal capacitance (62.2 mF/cm2), volumetric capacitance (207.4 F/cm3), and good cycling stability (97.2% after 2000 cycles and 90.4% after 10 000 cycles). aniline 20-27 PYD and CARD domain containing Homo sapiens 4-7 30881618-2 2019 The aim of this study was the bioisosteric replacement of benzene, methoxybenzene and aniline moieties of known potent GluN2B selective NMDA receptor antagonists by a thiophene ring. aniline 86-93 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 119-125 30592610-3 2019 In this study, we report a simple method to cross-link ENR with dodecanedioic acids (DAs) through esterification reaction, and during the cross-linking process, a little aniline trimer (ACAT, a kind of oligoaniline) was added at the same time. aniline 170-177 acetyl-CoA acetyltransferase 1 Homo sapiens 186-190 30081786-3 2019 Elevated expression of cyclins, cyclin-dependent kinases (CDKs) and phosphorylation of pRB protein along with increases in A, B and CDK1 as a cell cycle regulatory proteins cyclins, and reduce in CDK inhibitors (p21 and p27) could be critical in cell cycle regulation, which contributes to tumorigenic response after aniline exposure. aniline 317-324 cyclin-dependent kinase 1 Rattus norvegicus 132-136 30081786-4 2019 Aniline-induced splenic toxicity is correlated to oxidative DNA damage and initiation of DNA glycosylases expression (OGG1, NEIL1/2, NTH1, APE1 and PNK) for removal of oxidative DNA lesions in rat. aniline 0-7 8-oxoguanine DNA glycosylase Rattus norvegicus 118-122 30081786-4 2019 Aniline-induced splenic toxicity is correlated to oxidative DNA damage and initiation of DNA glycosylases expression (OGG1, NEIL1/2, NTH1, APE1 and PNK) for removal of oxidative DNA lesions in rat. aniline 0-7 nei-like DNA glycosylase 1 Rattus norvegicus 124-131 30081786-4 2019 Aniline-induced splenic toxicity is correlated to oxidative DNA damage and initiation of DNA glycosylases expression (OGG1, NEIL1/2, NTH1, APE1 and PNK) for removal of oxidative DNA lesions in rat. aniline 0-7 nth-like DNA glycosylase 1 Rattus norvegicus 133-137 30525603-2 2019 Initial studies of androgen receptor (AR) antagonist (1) and agonist (2) propanamides yielded a tertiary aniline (3) with novel SARD activity but poor metabolic stability. aniline 105-112 androgen receptor Homo sapiens 38-40 29964355-2 2018 NAT1 can also hydrolyze acetyl-coenzyme A (acetyl-CoA) in the absence of an arylamine substrate. aniline 76-85 N-acetyltransferase 1 Homo sapiens 0-4 29946589-0 2018 Rhodium-catalyzed oxidative C-H/C-H cross-coupling of aniline with heteroarene: N-nitroso group enabled mild conditions. aniline 54-61 churchill domain containing 1 Homo sapiens 28-35 30230334-0 2018 Highly Efficient Tuning of Ferromagnetic Spin Interactions in High-Spin Arylamine Structures by Incorporation of Spin Bearing Carbazole Units. aniline 72-81 spindlin 1 Homo sapiens 41-45 30230334-0 2018 Highly Efficient Tuning of Ferromagnetic Spin Interactions in High-Spin Arylamine Structures by Incorporation of Spin Bearing Carbazole Units. aniline 72-81 spindlin 1 Homo sapiens 67-71 30230334-0 2018 Highly Efficient Tuning of Ferromagnetic Spin Interactions in High-Spin Arylamine Structures by Incorporation of Spin Bearing Carbazole Units. aniline 72-81 spindlin 1 Homo sapiens 67-71 30230334-1 2018 Arylamine moieties oxidized to radical cations are considered promising spin bearing units in high-spin-type compounds. aniline 0-9 spindlin 1 Homo sapiens 72-76 30230334-1 2018 Arylamine moieties oxidized to radical cations are considered promising spin bearing units in high-spin-type compounds. aniline 0-9 spindlin 1 Homo sapiens 99-103 30221524-0 2018 Chiral Aniline Synthesis via Stereospecific C(sp3)-C(sp2) Coupling of Boronic Esters with Aryl Hydrazines. aniline 7-14 Sp2 transcription factor Homo sapiens 51-56 30149019-1 2018 N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. aniline 73-82 N-acetyltransferase 2 Homo sapiens 0-21 30149019-1 2018 N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. aniline 73-82 N-acetyltransferase 2 Homo sapiens 23-27 30102416-3 2018 The aim of this study is to investigate the effect of a novel Sig-1R agonist, aniline derivative compound (Comp-AD), on the ER stress response following ischemic stroke. aniline 78-85 sigma non-opioid intracellular receptor 1 Mus musculus 62-68 30261640-1 2018 In this study a cationic surfactant, cetyltrimethylammonium bromide (CTAB), was used as a soft template for in situ chemical polymerization of aniline on the surface of microcrystalline cellulose (MCC). aniline 143-150 MCC regulator of WNT signaling pathway Homo sapiens 197-200 29505746-1 2018 N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. aniline 153-163 N-acetyltransferase 2 Homo sapiens 0-21 29745962-1 2018 An efficient Fe(NO3)3 9H2O promoted ortho-nitration reaction of aniline derivatives has been developed. aniline 64-71 NBL1, DAN family BMP antagonist Homo sapiens 16-19 29505746-1 2018 N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. aniline 153-163 N-acetyltransferase 2 Homo sapiens 23-27 29505746-1 2018 N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. aniline 153-163 glutathione S-transferase kappa 1 Homo sapiens 61-65 29525435-0 2018 Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups. aniline 80-87 delta/notch like EGF repeat containing Homo sapiens 54-57 29525435-2 2018 Along this line, starting from PLK1-BRD4 dual inhibitor BI-2536, we discovered a new series of dihydroquinoxalin-2(1H)-one with aniline and indoline WPF binders as selective BRD4 inhibitors. aniline 128-135 polo like kinase 1 Homo sapiens 31-35 29525435-2 2018 Along this line, starting from PLK1-BRD4 dual inhibitor BI-2536, we discovered a new series of dihydroquinoxalin-2(1H)-one with aniline and indoline WPF binders as selective BRD4 inhibitors. aniline 128-135 bromodomain containing 4 Homo sapiens 36-40 29525435-2 2018 Along this line, starting from PLK1-BRD4 dual inhibitor BI-2536, we discovered a new series of dihydroquinoxalin-2(1H)-one with aniline and indoline WPF binders as selective BRD4 inhibitors. aniline 128-135 bromodomain containing 4 Homo sapiens 174-178 29623974-6 2018 For the Pd(0)-catalyzed intramolecular hydroamination of aniline-tethered MCP, the intramolecular nucleophilic attack of the amine moiety to C3/C4 of the corresponding metallacyclobutane intermediate is preferable to generate a cyclic intermediate. aniline 57-64 capping actin protein, gelsolin like Homo sapiens 74-77 29408119-0 2018 Removal of aniline from air and water by polymers of intrinsic microporosity (PIM-1) electrospun ultrafine fibers. aniline 11-18 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 78-83 29408119-1 2018 This research aims to investigate the possibility of electrospun fibers from Polymers of Intrinsic Microporosity (PIM-1) as an alternative adsorbent for aniline removal from both air and aqueous solution. aniline 153-160 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 114-119 29408119-3 2018 While electrospun PIM-1 nanofibrous mat can adsorb 871 mg g-1 aniline from air, it can also adsorb 78 +- 5.4 mg g-1 aniline from aqueous environment when 50 mg L-1 aniline solution is used. aniline 62-69 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 18-23 29408119-3 2018 While electrospun PIM-1 nanofibrous mat can adsorb 871 mg g-1 aniline from air, it can also adsorb 78 +- 5.4 mg g-1 aniline from aqueous environment when 50 mg L-1 aniline solution is used. aniline 116-123 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 18-23 29408119-5 2018 Langmuir and Freundlich isotherm models have been studied and Langmuir model found more appropriate for aniline adsorption on electrospun PIM-1 fibers. aniline 104-111 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 138-143 29256251-2 2018 A catalytic amount of aniline as a transient directing group was efficient for the ruthenium-catalyzed ortho-C(sp2)-H alkylation of benzaldehyde with maleimide. aniline 22-29 Sp2 transcription factor Homo sapiens 109-114 29587473-2 2018 Herein, an easily obtained catalyst system composed of zinc acetate and aniline was explored to mediate the fast ROP of gamma-benzyl-l-glutamate-N-carboxyanhydride (BLG-NCA) monomer, to produce poly(gamma-benzyl-l-glutamates) (PBLGs) with controllable molecular weights and narrow dispersity. aniline 72-79 CEA cell adhesion molecule 4 Homo sapiens 169-172 29587473-3 2018 Considering the excellent cooperative action of zinc acetate and a broad scope of aniline derivatives with different functional groups to control ROP of BLG-NCA, this method may offer a useful platform enabling the rapid generation of end-functionalized PBLG and block copolymers for numerous biomedical applications. aniline 82-89 CEA cell adhesion molecule 4 Homo sapiens 157-160 28816452-2 2017 In this transformation, the initial aerobic oxidation of the relatively active sp3 C-H bonds triggered the following intramolecular cyclization, in which the aniline group was employed as a removable auxiliary group to enable the consecutive process. aniline 158-165 Sp3 transcription factor Homo sapiens 79-82 29169673-1 2018 A novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP, compound 35 (GNE-207), has been identified through SAR investigations focused on optimizing al bicyclic heteroarene to replace the aniline present in the published GNE-272 series. aniline 209-216 CREB binding protein Homo sapiens 73-76 29169673-1 2018 A novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP, compound 35 (GNE-207), has been identified through SAR investigations focused on optimizing al bicyclic heteroarene to replace the aniline present in the published GNE-272 series. aniline 209-216 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Homo sapiens 91-94 28971668-4 2017 Species of O2 - were identified as primary radicals that triggered the spin-transfer from the triplet state of O2 to the aminobenzene ring of luminol by the aids of Au NCs, leading to an efficient phosphorescence. aniline 121-133 spindlin 1 Homo sapiens 71-75 28984450-8 2017 A base-catalyzed reaction pathway is elucidated for the conversion of Cd(PTC)2 to CdS, which includes phenylisothiocyanate and aniline as intermediates, and 1,3-diphenylthiourea as a final product. aniline 127-134 patched 2 Homo sapiens 73-78 28972750-3 2017 We report here the first low-valent, high-spin chromium-catalyzed cleavage of C(aryl)-N bonds in electronically neutral aniline derivatives at room temperature. aniline 120-127 spindlin 1 Homo sapiens 42-46 28742929-2 2017 In [Cu(N LH2 )]2+ the copper ion lies in an octahedral geometry with the aniline groups coordinated in equatorial positions. aniline 73-80 LIM homeobox 2 Homo sapiens 9-12 29180287-1 2018 Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the acetylation of arylamine carcinogens. aniline 80-89 N-acetyltransferase 1 Homo sapiens 0-31 29180287-1 2018 Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the acetylation of arylamine carcinogens. aniline 80-89 N-acetyltransferase 1 Homo sapiens 33-37 29180287-1 2018 Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the acetylation of arylamine carcinogens. aniline 80-89 N-acetyltransferase 2 Homo sapiens 46-50 29180287-2 2018 Single nucleotide polymorphisms in the NAT2 coding exon present in NAT2 haplotypes encode allozymes with reduced N-acetyltransferase activity towards the N-acetylation of arylamine carcinogens and the O-acetylation of their N-hydroxylated metabolites. aniline 171-180 N-acetyltransferase 2 Homo sapiens 39-43 29180287-2 2018 Single nucleotide polymorphisms in the NAT2 coding exon present in NAT2 haplotypes encode allozymes with reduced N-acetyltransferase activity towards the N-acetylation of arylamine carcinogens and the O-acetylation of their N-hydroxylated metabolites. aniline 171-180 N-acetyltransferase 2 Homo sapiens 67-71 29180287-3 2018 NAT2 acetylator phenotype modifies urinary bladder cancer risk following exposures to arylamine carcinogens such as 4-aminobiphenyl. aniline 86-95 N-acetyltransferase 2 Homo sapiens 0-4 28513914-3 2017 Proline and acid groups appended to catalytic fibers of two self-sorting hydrogelators compete for the Mannich reaction between aniline, benzaldehyde, and cyclohexanone to give low overall selectivity (anti/syn 77:23). aniline 128-135 synemin Homo sapiens 207-210 28436824-3 2017 In this work, a novel microbial electrolysis cell with bipolar membrane was integrated with Fenton reaction (MEC-Fenton) for efficient treatment of real wastewater containing a high concentration (4460 +- 52 mg L-1) of aniline. aniline 219-226 C-C motif chemokine ligand 28 Homo sapiens 109-112 28436824-6 2017 The applicability of bipolar membrane MEC-Fenton system was successfully demonstrated with actual aniline wastewater. aniline 98-105 C-C motif chemokine ligand 28 Homo sapiens 38-41 28463034-5 2017 Microarray and/or qPCR analyses showed that aniline exposure led to significantly decreased miRNA expression of let-7a, miR-24, miR-34c, miR-100, miR-125b, and greatly increased miR-181a. aniline 44-51 microRNA 34c Rattus norvegicus 128-135 28463034-5 2017 Microarray and/or qPCR analyses showed that aniline exposure led to significantly decreased miRNA expression of let-7a, miR-24, miR-34c, miR-100, miR-125b, and greatly increased miR-181a. aniline 44-51 microRNA 100 Rattus norvegicus 137-144 28463034-7 2017 Furthermore, remarkably enhanced expression of CDKs like CDK1, CDK2, CDK4, CDK6, especially p-CDK1 and p-CDK2 as well as alternations in the expression of pRB, p27, and CDC25A in the spleens of aniline-treated rats was also observed. aniline 194-201 cell division cycle 25A Rattus norvegicus 169-175 28776992-6 2017 Although aniline and pyridine derivatives interact with His342, benzonitriles conferred the best rat and human nNOS inhibition. aniline 9-16 nitric oxide synthase 1 Homo sapiens 111-115 28466599-3 2017 Pyrolysis of a nanocubic prussian blue analogue precursor (Km Mnx [Co(CN)6 ]y n H2 O) embedded in a bisphenol A and aniline-based pBO led to the formation of a N-doped carbon matrix modified with Mnx Coy Oz nanocubes. aniline 117-124 keratin 86 Homo sapiens 62-65 28621545-0 2017 Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp2-H/Csp3-Csp3 Activation. aniline 65-75 regulator of calcineurin 2 Homo sapiens 80-84 28466599-3 2017 Pyrolysis of a nanocubic prussian blue analogue precursor (Km Mnx [Co(CN)6 ]y n H2 O) embedded in a bisphenol A and aniline-based pBO led to the formation of a N-doped carbon matrix modified with Mnx Coy Oz nanocubes. aniline 117-124 keratin 86 Homo sapiens 197-200 30108853-0 2017 Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-kappaB) pathway and cell proliferation. aniline 26-33 nuclear factor kappa B subunit 1 Homo sapiens 116-138 30108853-0 2017 Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-kappaB) pathway and cell proliferation. aniline 26-33 nuclear factor kappa B subunit 1 Homo sapiens 140-149 30108853-1 2017 A series of inhibitors of NF-kappaB based on ursolic acid (UA) derivatives containing functionalized aniline or amide side chains were synthesized and evaluated for inhibition of NF-kappaB as well as their antitumor effects. aniline 101-108 nuclear factor kappa B subunit 1 Homo sapiens 26-35 30108853-6 2017 Thus, the rational design of UA derivatives with functionalized aniline or amide side chains offers significant potential for the discovery of a new class of NF-kappaB inhibitors with the ability to induce apoptosis and reverse multidrug resistance in the NCI-H460 lung adenocarcinoma cell line. aniline 64-71 nuclear factor kappa B subunit 1 Homo sapiens 158-167 28371253-4 2017 We used neutron diffraction to determine the positions of the hydrogen atoms in the ligands aniline and 2-aminopyridine bound to the archetypical serine protease trypsin. aniline 92-99 coagulation factor II, thrombin Homo sapiens 146-161 27567250-2 2017 The immunosensor has been constructed by immobilization of NGAL capture antibodies to electropolymerized aniline deposited on top of an electrosprayed graphene/polyaniline (G/PANI) modified screen printed carbon electrode. aniline 105-112 lipocalin 2 Homo sapiens 59-63 27641970-8 2017 The thermal stability of GOx increased by 8 C with aniline modification, while it decreased by 0.9 C upon modification with benzoate. aniline 51-58 hydroxyacid oxidase 1 Homo sapiens 25-28 27853051-1 2017 Since NAT2 single-nucleotide polymorphisms (SNPs) are responsible for the efficacy of arylamines and hydrazine drugs, defining the effects of these SNPs in various ethnicities is an important factor in the development of personalized medicine. aniline 86-96 N-acetyltransferase 2 Homo sapiens 6-10 28213709-5 2017 The superior adsorption characteristics of MIL-53(Al)-1 were preserved over a wide pH range (4-9), at high concentration of ionic strengths, and in the presence of coexisting compounds (anions, cations, phenol, aniline, and humic acid). aniline 211-218 ephrin A5 Homo sapiens 43-55 27722531-1 2016 The doubly acid-functionalised aniline PhN[(CH2)3B(C6F5)2]2 shows rapidly exchanging boron acid groups at the central base function and is an active frustrated Lewis pair due to cooperative hydride binding by both Lewis acids. aniline 31-38 carbamoyl-phosphate synthase 1 Homo sapiens 39-42 27614324-2 2017 Herein, a practical and green hydrothermal method was applied to fabricate terephthalic acid and pyromellitic acid intercalated layered double hydroxides (LDH) (named as TAL and PAL) for aniline efficient removal. aniline 187-194 transaldolase 1 Homo sapiens 170-173 27614324-3 2017 The sorption of aniline on LDH-based materials were investigated at different experimental conditions, and the results indicated that aniline sorption on LDH, TAL and PAL were strongly dependent on pH and independent of ionic strength. aniline 134-141 transaldolase 1 Homo sapiens 159-162 27614324-4 2017 The maximum sorption capacities of aniline on TAL and PAL at pH 5.0 and 293K were 90.4 and 130.0mg/g, respectively, which were significantly higher than that of aniline on LDH (52.6mg/g). aniline 35-42 transaldolase 1 Homo sapiens 46-49 27614324-4 2017 The maximum sorption capacities of aniline on TAL and PAL at pH 5.0 and 293K were 90.4 and 130.0mg/g, respectively, which were significantly higher than that of aniline on LDH (52.6mg/g). aniline 161-168 transaldolase 1 Homo sapiens 46-49 27614324-6 2017 The interactions of aniline with TAL and PAL were mainly dominated by hydrogen bonds and electrostatic interactions. aniline 20-27 transaldolase 1 Homo sapiens 33-36 27983649-1 2016 Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives (16a-p)) were designed and prepared via the introduction of a nitroimidazole group in the piperidine side chain and modification on the aniline moiety of vandetanib. aniline 306-313 epidermal growth factor receptor Homo sapiens 14-46 28474630-1 2016 BACKGROUND & OBJECTIVES: The N-acetyltransferase 2 (NAT2) gene encodes an enzyme which both activates and deactivates arylamine and other drugs and carcinogens. aniline 122-131 N-acetyltransferase 2 Homo sapiens 33-54 28474630-1 2016 BACKGROUND & OBJECTIVES: The N-acetyltransferase 2 (NAT2) gene encodes an enzyme which both activates and deactivates arylamine and other drugs and carcinogens. aniline 122-131 N-acetyltransferase 2 Homo sapiens 56-60 27711874-3 2016 In comparison with gold NPs supported by a non-ionic analogue from the Yamamoto reaction of tetrakis(4-bromophenyl)methane (Au@POP-TPM), Au@Im-POP-2 exhibits high catalytic activity, good selectivity of aniline and superior recyclability in nitrobenzene reduction. aniline 203-210 pyrin domain containing 2 Homo sapiens 143-148 27754691-2 2016 The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C(sp2)-N bond under mild conditions. aniline 58-68 Sp2 transcription factor Homo sapiens 109-114 27916916-5 2016 Levels of ROS and MDA were significantly increased and levels of GSH and CAT, activity of SOD, and mitochondrial membrane potential in hepatocytes were significantly decreased by aniline compared with the negative control group. aniline 179-186 catalase Homo sapiens 73-76 27005699-4 2016 By introducing a CF3-group at the 4-position of the benzylamine moiety, combined with a fluorine atom at the 3-position of the aniline ring, we generated Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate (RL648_81), a new KCNQ2/3-specific activator that is >15 times more potent and also more selective than retigabine. aniline 127-134 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 249-254 31457120-5 2016 While precisely manipulating the nanocomposite formation, we observed efficient visible-light-driven photocatalytic application of graphene-stacked SnS2 NDs in the quantitative synthesis of aniline (99.9% yield, absolute selectivity) from nitrobenzene (>99.9% conversion), in the reduction of toxic Cr(VI) to nontoxic Cr(III), and in the degradation of mutagenic organic dyes. aniline 190-197 sodium voltage-gated channel alpha subunit 11 Homo sapiens 148-152 27102572-8 2016 Analysis of substituent patterns suggested that EGFR-inhibitors with small aniline substituents in the 4-position of the quinazoline ring were more effective than inhibitors with large substituents in that position. aniline 75-82 epidermal growth factor receptor Homo sapiens 48-52 27497348-2 2016 The maximum adsorption capacity of aniline for the studied AC was from 138.9 to 257.9 mg g(-1) at 296.15 K and it was observed to be strongly related to the textural properties of the AC, mainly with the BET surface area and the micropore volume. aniline 35-42 delta/notch like EGF repeat containing Homo sapiens 204-207 27499251-0 2016 Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. aniline 30-37 G protein-coupled receptor 88 Homo sapiens 52-57 27499251-0 2016 Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. aniline 30-37 propionyl-CoA carboxylase subunit alpha Homo sapiens 68-72 27499251-4 2016 Early structure-activity relationship (SAR) studies suggested that the aniline moiety of 2-PCCA is a suitable site for diverse modifications. aniline 71-78 propionyl-CoA carboxylase subunit alpha Homo sapiens 91-95 27497234-5 2016 In comparison with human CYP2E1, camel CYP2E1 more efficiently binds to small toxins as aniline, benzene, catechol, amides, butadiene, toluene and acrylamide. aniline 88-95 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 25-31 27497234-5 2016 In comparison with human CYP2E1, camel CYP2E1 more efficiently binds to small toxins as aniline, benzene, catechol, amides, butadiene, toluene and acrylamide. aniline 88-95 cytochrome P450 2E1 Camelus bactrianus 39-45 27440500-1 2016 The doubly Lewis-acid functionalised aniline PhN[(CH2)3B(C6F5)2]2 features two competing boron functions in fast exchange for binding to the central Lewis base. aniline 37-44 carbamoyl-phosphate synthase 1 Homo sapiens 45-48 27136043-3 2016 METHODS: NAT2 haplotypes comprising SNPs rs1801279, rs1041983, rs1801280, rs1799929, rs1799930, rs1208 and rs1799931 were assigned according to the arylamine N-acetyltransferases database. aniline 148-157 N-acetyltransferase 2 Homo sapiens 9-13 27131125-5 2016 While both periodate oxidation and aniline-catalyzed oxime ligation (PAL) and galactose oxidase and aniline-catalyzed oxime ligation (GAL) can be used to monitor neuraminidase activity toward glycans in microtiter plates, only GAL accurately measured neuraminidase activity toward glycans displayed on a commercial glass slide microarray. aniline 35-42 neuraminidase 1 Homo sapiens 162-175 27131125-5 2016 While both periodate oxidation and aniline-catalyzed oxime ligation (PAL) and galactose oxidase and aniline-catalyzed oxime ligation (GAL) can be used to monitor neuraminidase activity toward glycans in microtiter plates, only GAL accurately measured neuraminidase activity toward glycans displayed on a commercial glass slide microarray. aniline 100-107 neuraminidase 1 Homo sapiens 162-175 27131125-5 2016 While both periodate oxidation and aniline-catalyzed oxime ligation (PAL) and galactose oxidase and aniline-catalyzed oxime ligation (GAL) can be used to monitor neuraminidase activity toward glycans in microtiter plates, only GAL accurately measured neuraminidase activity toward glycans displayed on a commercial glass slide microarray. aniline 100-107 neuraminidase 1 Homo sapiens 251-264 27004891-0 2016 Determination of the solid surface critical exponent beta1 from contact-angle variation on approach to a wetting transition: Cyclohexane/aniline/quartz. aniline 137-144 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 53-58 26876861-2 2016 PANI nanofillers (one-dimentional tubes and three-dimentional particles) were synthesized via oxidative polymerization of aniline in aqueous media and, then, embedded in the HEC matrix. aniline 122-129 synaptophysin-like protein Mus musculus 0-4 26865481-0 2016 Coupling of bio-PRB and enclosed in-well aeration system for remediation of nitrobenzene and aniline in groundwater. aniline 93-100 RB transcriptional corepressor 1 Homo sapiens 16-19 26865481-1 2016 A laboratory-scale bio-permeable reactive barrier (bio-PRB) was constructed and combined with enclosed in-well aeration system to treat nitrobenzene (NB) and aniline (AN) in groundwater. aniline 158-165 RB transcriptional corepressor 1 Homo sapiens 55-58 26829280-1 2016 With the aim of overcoming gefitinib resistance, a series of novel quinazoline derivatives bearing an adamantyl group on the aniline ring were synthesized as potent epidermal growth factor receptor (EGFR) inhibitors. aniline 125-132 epidermal growth factor receptor Homo sapiens 165-197 26829280-1 2016 With the aim of overcoming gefitinib resistance, a series of novel quinazoline derivatives bearing an adamantyl group on the aniline ring were synthesized as potent epidermal growth factor receptor (EGFR) inhibitors. aniline 125-132 epidermal growth factor receptor Homo sapiens 199-203 26769627-1 2015 A new G-quadruplex (G-4)-directing alkylating agent BMVC-C3M was designed and synthesized to integrate 3,6-bis(1-methyl-4-vinylpyridinium iodide)carbazole (BMVC) with aniline mustard. aniline 167-174 chromosome 6 open reading frame 47 Homo sapiens 20-23 26473334-4 2016 In a systematic study, we investigated the influence of the alkoxy substitution in ortho position of the aniline moiety in pi-conjugated aniline-1,2,3-triazole-coumarin-fluoroionophores 4, 5 and 6 [R=MeO (4), EtO (5) and iPrO (6)] towards the K(+) -complex stability and K(+) /Na(+) selectivity. aniline 105-112 RUNX1 partner transcriptional co-repressor 1 Homo sapiens 209-212 26368826-1 2015 A rearrangement reaction of 1,2-cyclopropanated sugars with alkylamines or arylamines promoted by Zn(OTf)2 is described. aniline 75-85 POU class 2 homeobox 2 Homo sapiens 101-106 26102013-3 2015 HL-60 cells contain abundant amounts of myeloperoxidase (MPO), a hemoprotein, which catalyzes one-electron oxidation of arylamines using H2O2 as a cofactor. aniline 120-130 myeloperoxidase Homo sapiens 40-55 26444694-3 2015 In this context, different arylamine dye-based electron donor moieties (TRA, CRA and PyRA) were successfully synthesized and well characterized using (1)H-NMR, (13)C-NMR and EI-MS spectrometry. aniline 27-36 T cell receptor alpha locus Homo sapiens 72-75 26444694-3 2015 In this context, different arylamine dye-based electron donor moieties (TRA, CRA and PyRA) were successfully synthesized and well characterized using (1)H-NMR, (13)C-NMR and EI-MS spectrometry. aniline 27-36 myotubularin related protein 11 Homo sapiens 77-80 26469213-0 2015 Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. aniline 18-25 nitric oxide synthase 1 Homo sapiens 93-123 26259604-5 2015 Here, we show through steroidogenic profiling that exposure to aniline led to increased levels of the Delta4 steroids, suggesting that the activity of CYP21 was decreased. aniline 63-70 delta like canonical Notch ligand 4 Homo sapiens 102-108 26259604-5 2015 Here, we show through steroidogenic profiling that exposure to aniline led to increased levels of the Delta4 steroids, suggesting that the activity of CYP21 was decreased. aniline 63-70 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 151-156 26102013-3 2015 HL-60 cells contain abundant amounts of myeloperoxidase (MPO), a hemoprotein, which catalyzes one-electron oxidation of arylamines using H2O2 as a cofactor. aniline 120-130 myeloperoxidase Homo sapiens 57-60 26102013-4 2015 Previous studies have shown that arylamine metabolism by MPO results in protein radical formation. aniline 33-42 myeloperoxidase Homo sapiens 57-60 26305174-1 2015 A Rh(II)/chiral phosphoric acid cocatalyzed four-component reaction of indoles, 3-diazooxindoles, arylamines, and ethyl glyoxylate is developed, offering an extremely efficient strategy for the construction of 3,3-disubstituted 3-indol-3"-yloxindoles with excellent diastereoselectivities and high to excellent enantioselectivities. aniline 98-108 Rh blood group D antigen Homo sapiens 2-8 32262779-0 2015 Preparation of a cobalt mono-substituted silicotungstic acid doped with aniline for the selective adsorption of ovalbumin. aniline 72-79 ovalbumin (SERPINB14) Gallus gallus 112-121 26222195-2 2015 In humans, cytochrome P450 1A2 is the major enzyme metabolizing environmental arylamines or heterocyclic amines into carcinogens. aniline 78-88 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 11-30 25991687-5 2015 Periodate oxidation and aniline-catalyzed oxime ligation technology was applied with subsequent quantitative liquid chromatography-tandem MS to generate a data set describing the surface proteome of primary human naive CD4(+) T cells and to monitor dynamic changes during the early phase of activation. aniline 24-31 CD4 molecule Homo sapiens 219-222 26192324-4 2015 Despite our demonstration that cell proliferation was associated with deregulation of G1 phase cyclins and increased expression of G1 phase cyclin-dependent kinases (CDKs), molecular mechanisms, especially the regulation of G2 phase and contribution of epigenetic mechanisms in aniline-induced splenic cellular proliferation remain largely unclear. aniline 278-285 cyclin-dependent kinase 1 Rattus norvegicus 166-170 26192324-7 2015 Aniline treatment resulted in significant increases in cell cycle regulatory proteins, including cyclins A, B and CDK1, particularly phosphor-CDK1, and decreases in CDK inhibitors p21 and p27, which could promote the splenocytes to go through G2/M transition. aniline 0-7 cyclin-dependent kinase 1 Rattus norvegicus 114-118 26192324-7 2015 Aniline treatment resulted in significant increases in cell cycle regulatory proteins, including cyclins A, B and CDK1, particularly phosphor-CDK1, and decreases in CDK inhibitors p21 and p27, which could promote the splenocytes to go through G2/M transition. aniline 0-7 cyclin-dependent kinase 1 Rattus norvegicus 142-146 26192324-7 2015 Aniline treatment resulted in significant increases in cell cycle regulatory proteins, including cyclins A, B and CDK1, particularly phosphor-CDK1, and decreases in CDK inhibitors p21 and p27, which could promote the splenocytes to go through G2/M transition. aniline 0-7 KRAS proto-oncogene, GTPase Rattus norvegicus 180-183 26192324-7 2015 Aniline treatment resulted in significant increases in cell cycle regulatory proteins, including cyclins A, B and CDK1, particularly phosphor-CDK1, and decreases in CDK inhibitors p21 and p27, which could promote the splenocytes to go through G2/M transition. aniline 0-7 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 188-191 26192324-8 2015 Our data also showed upregulation of tumor markers Trx-1 and Ref-1 in rats treated with aniline. aniline 88-95 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 61-66 26168740-2 2015 NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. aniline 105-115 N-acetyltransferase 1 Homo sapiens 0-4 25877134-0 2015 Trio catalysis merging enamine, bronsted Acid, and metal lewis Acid catalysis: asymmetric three-component aza-diels-alder reaction of substituted cinnamaldehydes, cyclic ketones, and arylamines. aniline 183-193 trio Rho guanine nucleotide exchange factor Homo sapiens 0-4 25877134-1 2015 A trio catalyst system, composed of arylamine, BINOL-derived phosphoric acid, and Y(OTf)3 , enables the combination of enamine catalysis with both hard metal Lewis acid catalysis and Bronsted acid catalysis for the first time. aniline 36-45 trio Rho guanine nucleotide exchange factor Homo sapiens 2-6 24909677-1 2014 A knowledge-based library of 2,3-dichlorophenylsulfonyl derivatives of commercially available aryl amines was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme. aniline 94-105 C-C motif chemokine receptor 4 Homo sapiens 144-148 25798622-6 2015 NAT2 acetylates arylamine and hydrazine drugs and carcinogens, but predicted acetylator NAT2 phenotypes were not associated with insulin sensitivity. aniline 16-25 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 0-4 25690452-3 2015 The present study utilized [(18) F]-labeled aniline as intermediate in [(18) F]-radiolabeling chemistry for the facile radiosynthesis of 4-amino-N-(3-chloro-4-fluorophenyl)-N"-hydroxy-1,2,5-oxadiazole-3-carboximidamide ([(18) F]IDO5L) as indoleamine 2,3-dioxygenase 1 (IDO1) targeted tracer. aniline 44-51 indoleamine 2,3-dioxygenase 1 Homo sapiens 238-267 25690452-3 2015 The present study utilized [(18) F]-labeled aniline as intermediate in [(18) F]-radiolabeling chemistry for the facile radiosynthesis of 4-amino-N-(3-chloro-4-fluorophenyl)-N"-hydroxy-1,2,5-oxadiazole-3-carboximidamide ([(18) F]IDO5L) as indoleamine 2,3-dioxygenase 1 (IDO1) targeted tracer. aniline 44-51 indoleamine 2,3-dioxygenase 1 Homo sapiens 269-273 25711163-1 2015 The nickel-catalyzed amination of aryl chlorides to form primary arylamines occurs with ammonia or ammonium sulfate and a well-defined single-component nickel(0) precatalyst containing a Josiphos ligand and an eta(2)-bound benzonitrile ligand. aniline 65-75 endothelin receptor type A Homo sapiens 210-213 25682008-5 2015 After analysis, the results indicated that three Gst Delta genes (Gst D2, Gst D5 and Gst D6) were found to show a peak of up-regulated transcriptional response at 6-8h of exposure of aniline. aniline 183-190 Glutathione S transferase D2 Drosophila melanogaster 66-72 25682008-5 2015 After analysis, the results indicated that three Gst Delta genes (Gst D2, Gst D5 and Gst D6) were found to show a peak of up-regulated transcriptional response at 6-8h of exposure of aniline. aniline 183-190 Glutathione S transferase D5 Drosophila melanogaster 74-80 25682008-5 2015 After analysis, the results indicated that three Gst Delta genes (Gst D2, Gst D5 and Gst D6) were found to show a peak of up-regulated transcriptional response at 6-8h of exposure of aniline. aniline 183-190 Glutathione S transferase D6 Drosophila melanogaster 85-91 25623286-1 2015 An azide (-N3) group attached at the -ortho carbon atom to the aniline moiety of 2-anilino-4,6-di-tert-butylphenol formed a diradical-containing Co(II) complex via inter-ligand azo (N=N) bond formation. aniline 63-70 mitochondrially encoded cytochrome c oxidase II Homo sapiens 145-151 25557011-0 2015 Correction: Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates. aniline 74-83 myoglobin Homo sapiens 12-21 25557011-1 2015 Correction for "Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates" by Gopeekrishnan Sreenilayam et al., Chem. aniline 78-87 myoglobin Homo sapiens 16-25 25124116-3 2014 Structural modification of parent quinazoline scaffolds by introducing substituents on aniline displayed potent inhibitory activities toward EphA2. aniline 87-94 EPH receptor A2 Homo sapiens 141-146 26377014-8 2015 As the aniline ring was substituted by a strong electron-withdrawing group (e.g., NO(2), COCH(3), or CF(3)) at the para position, a characteristic phenolate anion was obtained, which was derived from the Smiles rearrangement reaction initiated by the oxygen anion through a four-membered ring transition state. aniline 7-14 cochlin Homo sapiens 89-93 25804257-6 2015 The inhibitor sulfaphenazole, in addition to the previously studied aniline, increased the barrier height for electron transfer and thereby makes CYP2C9 reduction more difficult and inhibits metabolism. aniline 68-75 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 146-152 25504318-0 2015 Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates. aniline 62-71 myoglobin Homo sapiens 0-9 25504318-1 2015 Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of alpha-diazo esters into the N-H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope. aniline 143-153 myoglobin Homo sapiens 51-60 25363163-2 2014 The samples were characterized by SEM, TEM, XRD, TPD, and BET and were employed for fixation of CO2 on aniline to produce pharmaceutically important acetanilide under mild reaction conditions (150 C and 150 Psi CO2 pressure). aniline 103-110 delta/notch like EGF repeat containing Homo sapiens 58-61 25432241-7 2014 All three exhibited diminished activity towards "(MOUSE)NAT2-specific" arylamines but were more active against hydrazines than (MOUSE)NAT1*1. aniline 71-81 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 56-60 25305687-1 2014 The interactions of gefitinib (Iressa) in EGFR are hydrogen bonding and van der Waals forces through quinazoline and aniline rings. aniline 117-124 epidermal growth factor receptor Homo sapiens 42-46 24928356-1 2014 N-acetyltransferase (NAT2) is a phase-II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines, aromatic amines and hydrazines. aniline 117-127 N-acetyltransferase 2 Homo sapiens 21-25 25343551-1 2014 AIMS AND BACKGROUND: Cytochrome P450 (CYP) 1A1 enzyme plays an important role in the metabolism of carcinogens, such as polycyclic aromatic hydrocarbons, nitroaromatics and arylamines. aniline 173-183 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-46 24737104-6 2014 However, the copolymers with the aniline pentamer in the leucoemeraldine state had significantly lower CMCs than the copolymers with the aniline pentamer in the emeraldine state. aniline 33-40 G protein signaling modulator 2 Homo sapiens 103-107 25037918-3 2014 Elaboration of the pyrazole-based ureas provided remarkably potent irreversible inhibitors of fatty acid amide hydrolase (FAAH, apparent Ki=100-200 pM) complementary to those previously disclosed enlisting electron-deficient aniline-based ureas. aniline 225-232 fatty acid amide hydrolase Homo sapiens 122-126 25005845-1 2014 N-Acetyltransferase 2 (NAT2) is a polymorphic gene encoding the enzyme that metabolizes arylamine and hydrazine moieties. aniline 88-97 N-acetyltransferase 2 Homo sapiens 0-21 25005845-1 2014 N-Acetyltransferase 2 (NAT2) is a polymorphic gene encoding the enzyme that metabolizes arylamine and hydrazine moieties. aniline 88-97 N-acetyltransferase 2 Homo sapiens 23-27 24927757-0 2014 Ferromagnetic Spin Coupling through the 3,4"-Biphenyl Moiety in Arylamine Oligomers-Experimental and Computational Study. aniline 64-73 spindlin 1 Homo sapiens 14-18 24811756-2 2014 Glucose oxidase (GOx) was used as an effective catalyst producing hydrogen peroxide, in the presence of glucose, for the oxidative polymerization of aniline under ambient conditions. aniline 149-156 hydroxyacid oxidase 1 Homo sapiens 0-15 24811756-2 2014 Glucose oxidase (GOx) was used as an effective catalyst producing hydrogen peroxide, in the presence of glucose, for the oxidative polymerization of aniline under ambient conditions. aniline 149-156 hydroxyacid oxidase 1 Homo sapiens 17-20 24785981-3 2014 The enzymatic oxidation products of beta2-agonists with phenolic groups exhibited different color transitions based on the different substituent groups on the aromatic ring, whereas beta2-agonists with the aniline group or the resorcinol group remained colorless. aniline 206-213 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 36-41 24785981-3 2014 The enzymatic oxidation products of beta2-agonists with phenolic groups exhibited different color transitions based on the different substituent groups on the aromatic ring, whereas beta2-agonists with the aniline group or the resorcinol group remained colorless. aniline 206-213 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 182-187 24345333-0 2014 CYP2E1 hydroxylation of aniline involves negative cooperativity. aniline 24-31 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 24330598-3 2014 Compounds A2, A8, and A9 exhibited potent Bcr-Abl inhibitory activity, suggesting that aniline containing halogen substituents might be important for biological activity. aniline 87-94 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 42-49 24701913-6 2014 Based on this comparative study, the effective order for aniline rejection is: HR98PP > NF97 > DESAL3B > SEPA-MS05 > NF99HF. aniline 57-64 extra spindle pole bodies like 1, separase Homo sapiens 114-118 24440299-2 2014 Previously described aniline 2 had suboptimal efficacy in signaling assays using cynomolgus monkey (cyno) GPR119 making evaluation of the target in preclinical models difficult. aniline 21-28 glucose-dependent insulinotropic receptor Macaca fascicularis 106-112 24764957-1 2014 In the title mol-ecule, C14H17NO, the 5,5-di-methyl-cyclo-hex-2-enone moiety is attached to an aniline group, the dihedral angle subtended [54.43 (3) ] indicating a significant twist. aniline 95-102 hematopoietically expressed homeobox Homo sapiens 58-61 24345333-8 2014 Scaled modeling of in vitro CYP2E1 metabolism of aniline to in vivo clearance, especially at low aniline levels, led to significant deviations from the traditional model based on non-cooperative, Michaelis-Menten kinetics. aniline 97-104 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 28-34 24345333-9 2014 These findings provide a critical mechanistic perspective on the potential importance of CYP2E1 in the metabolic activation and elimination of aniline as well as the first experimental evidence of a negatively cooperative metabolic reaction catalyzed by CYP2E1. aniline 143-150 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 89-95 24345333-9 2014 These findings provide a critical mechanistic perspective on the potential importance of CYP2E1 in the metabolic activation and elimination of aniline as well as the first experimental evidence of a negatively cooperative metabolic reaction catalyzed by CYP2E1. aniline 143-150 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 254-260 24345333-1 2014 CYP2E1 plays a role in the metabolic activation and elimination of aniline, yet there are conflicting reports on its mechanism of action, and hence relevance, in aniline metabolism. aniline 67-74 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 24345333-1 2014 CYP2E1 plays a role in the metabolic activation and elimination of aniline, yet there are conflicting reports on its mechanism of action, and hence relevance, in aniline metabolism. aniline 162-169 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 24345333-2 2014 Based on our work with similar compounds, we hypothesized that aniline binds two CYP2E1 sites during metabolism resulting in cooperative reaction kinetics and tested this hypothesis through rigorous in vitro studies. aniline 63-70 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 81-87 24345333-4 2014 Mechanistically, the data were best explained through a two-binding site cooperative model in which aniline binds with high affinity (K(s)=30 muM) followed by a second weaker binding event (K(ss)=1100 uM) resulting in a threefold increase in the oxidation rate. aniline 100-107 latexin Homo sapiens 142-145 24345333-6 2014 Inhibitor phenotyping experiments with human liver microsomes validated the central role for CYP2E1 in aniline hydroxylation and indicated minor roles for CYP2A6 and CYP2C9. aniline 103-110 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 93-99 24345333-8 2014 Scaled modeling of in vitro CYP2E1 metabolism of aniline to in vivo clearance, especially at low aniline levels, led to significant deviations from the traditional model based on non-cooperative, Michaelis-Menten kinetics. aniline 49-56 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 28-34 24369964-2 2014 Different directing groups, such as pyridine, pyrimidine, pyrazole, and N-OMe oxime, can be employed in this C-H amidation process, providing valuable N-carbamate-protected arylamines (e.g., Cbz, Moz, Ac, Boc, and Fmoc). aniline 173-183 lysine acetyltransferase 6A Homo sapiens 196-199 24369964-2 2014 Different directing groups, such as pyridine, pyrimidine, pyrazole, and N-OMe oxime, can be employed in this C-H amidation process, providing valuable N-carbamate-protected arylamines (e.g., Cbz, Moz, Ac, Boc, and Fmoc). aniline 173-183 BOC cell adhesion associated, oncogene regulated Homo sapiens 205-208 24465076-0 2014 Equilibrium Study of Pd(dba)2 and P(OPh)3 in the Pd-Catalyzed Allylation of Aniline by Allyl Alcohol. aniline 76-83 DBA2 Homo sapiens 21-29 24304177-1 2013 An unexpected cascade reaction of 2-aminobenzaldehydes with arylamines catalyzed by scandium pentafluorobenzoate [Sc(Pfb)3] was reported as a facile strategy for the efficient synthesis of a novel class of polycyclic ring-fused aminals N-substituted-6,7,11b,13-tetrahydro-6,12-[1,2]benzenoquinazolino[3,4-a]quinazolin-13-amines 1. aniline 60-70 keratin 75 Homo sapiens 117-120 24347068-3 2014 Among the three Ir/CNF samples, Ir/CNF-T showed an excellent catalytic activity and chemoselectivity towards hydrogenation of functionalized nitroarenes and imines; the corresponding aniline derivatives were obtained with high turnover numbers at ambient temperature under 10 tm of H2 , and the catalyst is reusable. aniline 183-190 NPHS1 adhesion molecule, nephrin Homo sapiens 19-22 24269511-4 2014 SAR and docking studies allowed the identification of pharmacophoric groups for both kinases and demonstrated the importance of a hydrogen bond donor at the para position of the aniline moiety for interaction with conserved Glu and Asp amino acids in EGFR and VEGFR-2 binding sites. aniline 178-185 epidermal growth factor receptor Homo sapiens 251-255 24269511-4 2014 SAR and docking studies allowed the identification of pharmacophoric groups for both kinases and demonstrated the importance of a hydrogen bond donor at the para position of the aniline moiety for interaction with conserved Glu and Asp amino acids in EGFR and VEGFR-2 binding sites. aniline 178-185 kinase insert domain receptor Homo sapiens 260-267 24266650-3 2013 We show that both coordinated anilido groups of the neutral Co(II) complex can be protonated into aniline form. aniline 98-105 mitochondrially encoded cytochrome c oxidase II Homo sapiens 60-66 24184213-8 2013 On the aniline ring at position 4 of the quinazoline moiety substituents like NO2, CN, CF3 led to very high BCRP inhibition potencies. aniline 7-14 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 108-112 24231331-5 2013 The results showed that their lnk" values followed the order: benzene < toluene < phenol < chlorobenzene < bromobenzene < aniline < sulfamethoxazole < sulfadiazine sulfadimidine. aniline 137-144 SH2B adaptor protein 3 Homo sapiens 30-33 23287855-4 2013 In vitro analysis suggested that the purified CYP102A5 metabolizes typical substrates of human CYP2C9, CYP2D6, CYP2E1, and CYP3A4, such as coumarin, propranolol, aniline, chlorzoxazone, p-nitrophenol, and nifedipine. aniline 162-169 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 95-101 24121341-9 2013 The result revealed that the orientation of ANS binding to FABP3 is completely opposite to that of ANS binding to FABP4, and the substitution of valine in FABP4 to leucine in FABP3 may result in greater steric hindrance between the side-chain of Leu115 and the aniline ring of ANS. aniline 261-268 fatty acid binding protein 3 Homo sapiens 59-64 24121341-9 2013 The result revealed that the orientation of ANS binding to FABP3 is completely opposite to that of ANS binding to FABP4, and the substitution of valine in FABP4 to leucine in FABP3 may result in greater steric hindrance between the side-chain of Leu115 and the aniline ring of ANS. aniline 261-268 fatty acid binding protein 4 Homo sapiens 155-160 24121341-9 2013 The result revealed that the orientation of ANS binding to FABP3 is completely opposite to that of ANS binding to FABP4, and the substitution of valine in FABP4 to leucine in FABP3 may result in greater steric hindrance between the side-chain of Leu115 and the aniline ring of ANS. aniline 261-268 fatty acid binding protein 3 Homo sapiens 175-180 24041549-1 2013 In this paper, a facile and efficient method is reported to prepare polyaniline/carbon nanofiber (PANI/CNF) hybrid films by in situ chemical polymerization of aniline. aniline 72-79 NPHS1 adhesion molecule, nephrin Homo sapiens 103-106 24041549-2 2013 The various morphologies and microstructures of PANI/CNF hybrid films can be controlled by adjusting the concentration of aniline and different acids as the protonation reagent, and the formation mechanism is illustrated in this study. aniline 122-129 NPHS1 adhesion molecule, nephrin Homo sapiens 53-56 24319536-2 2013 Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved in the metabolism of carcinogens, such as arylamines and heterocyclic amines, implicated in bladder cancer. aniline 191-201 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-19 24319536-2 2013 Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved in the metabolism of carcinogens, such as arylamines and heterocyclic amines, implicated in bladder cancer. aniline 191-201 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 21-27 24319536-2 2013 Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved in the metabolism of carcinogens, such as arylamines and heterocyclic amines, implicated in bladder cancer. aniline 191-201 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-61 24319536-2 2013 Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved in the metabolism of carcinogens, such as arylamines and heterocyclic amines, implicated in bladder cancer. aniline 191-201 NAD(P)H quinone dehydrogenase 1 Homo sapiens 63-67 24319536-2 2013 Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved in the metabolism of carcinogens, such as arylamines and heterocyclic amines, implicated in bladder cancer. aniline 191-201 N-acetyltransferase 1 Homo sapiens 74-94 24319536-2 2013 Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved in the metabolism of carcinogens, such as arylamines and heterocyclic amines, implicated in bladder cancer. aniline 191-201 N-acetyltransferase 1 Homo sapiens 96-100 23287855-4 2013 In vitro analysis suggested that the purified CYP102A5 metabolizes typical substrates of human CYP2C9, CYP2D6, CYP2E1, and CYP3A4, such as coumarin, propranolol, aniline, chlorzoxazone, p-nitrophenol, and nifedipine. aniline 162-169 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 103-109 23287855-4 2013 In vitro analysis suggested that the purified CYP102A5 metabolizes typical substrates of human CYP2C9, CYP2D6, CYP2E1, and CYP3A4, such as coumarin, propranolol, aniline, chlorzoxazone, p-nitrophenol, and nifedipine. aniline 162-169 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 111-117 23287855-4 2013 In vitro analysis suggested that the purified CYP102A5 metabolizes typical substrates of human CYP2C9, CYP2D6, CYP2E1, and CYP3A4, such as coumarin, propranolol, aniline, chlorzoxazone, p-nitrophenol, and nifedipine. aniline 162-169 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 123-129 23686094-4 2013 The CCNH torsional angles in the m-PDA and p-PDA isomers were calculated to be about 25-26 as compared to 20 in aniline. aniline 114-121 cyclin H Homo sapiens 4-8 23873588-6 2013 The consequence is that typical bases like aniline or formamide lead to BeX2 complexes that are stronger acids than phosphoric or chloric acids. aniline 43-50 brain expressed X-linked 2 Homo sapiens 72-76 23802889-0 2013 Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter. aniline 19-26 solute carrier family 18 member A3 Rattus norvegicus 76-111 23352893-9 2013 Likewise, Western blot analysis showed that protein expression of NTH1 and APE1 in the nuclear extracts of spleen from aniline-treated rats was 1.9- and 2.7-fold higher than the controls, respectively. aniline 119-126 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 75-79 23578993-9 2013 Cytochrome P450 2E1 (CYP 450 2E1), activity was determined as hydroxylation of aniline in liver microsomes. aniline 79-86 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 0-19 23602960-1 2013 Benzylidene anilines with p-substituted styryl groups substituted on the aniline ring, p-X-PhCH=NPhCH=CHPh-p-Y (X=NMe2, OMe, Me, H, Cl, F, CN, or NO2; Y=NMe2, OMe, Me, H, Cl, or CN) have been studied photochemically in ethanol. aniline 12-19 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 114-118 23602960-1 2013 Benzylidene anilines with p-substituted styryl groups substituted on the aniline ring, p-X-PhCH=NPhCH=CHPh-p-Y (X=NMe2, OMe, Me, H, Cl, F, CN, or NO2; Y=NMe2, OMe, Me, H, Cl, or CN) have been studied photochemically in ethanol. aniline 12-19 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 153-157 23710622-5 2013 It contained a methylcyclohexyl derivative of 4-aminophenylalanine, and its cocrystal structure with gp120 revealed the cyclohexane ring buried within the gp120 hydrophobic core but able to assume multiple orientations in the binding pocket, and the aniline nitrogen potentially providing a focus for further improvement. aniline 250-257 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 101-106 23659855-1 2013 A series of CCR1 antagonists based upon spirocyclic compounds 1b and 2b were synthesised in which substituted aniline moiety was replaced with substituted benzamides. aniline 110-117 C-C motif chemokine receptor 1 Homo sapiens 12-16 23614840-0 2013 Sc(OTf)3-catalyzed three-component cyclization of arylamines, beta,gamma-unsaturated alpha-ketoesters, and 1,3-dicarbonyl compounds for the synthesis of highly substituted 1,4-dihydropyridines and tetrahydropyridines. aniline 50-60 POU class 5 homeobox 1 Homo sapiens 0-8 23614840-1 2013 A Sc(OTf)3-catalyzed three-component cyclization reaction of arylamines, beta,gamma-unsaturated alpha-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center. aniline 61-71 POU class 5 homeobox 1 Homo sapiens 2-10 23542318-2 2013 The results showed that Shewanella/AQS-PUF significantly accelerated nitrobenzene bio-reduction (95.6%) and aniline formation (94.3%) with nitrobenzene removal rate up to 0.13 mM h(-1). aniline 108-115 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 39-42 23425124-8 2013 Our results show that mPDA can release and label 15 times more protein than aniline can in 3 h. Then, using the new catalyst, ciliary neurotrophic factor, a protein with therapeutic potential, was successfully labeled with a fluorophore in only 5 min. aniline 76-83 ciliary neurotrophic factor Homo sapiens 126-153 23352893-0 2013 Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure. aniline 80-87 nth-like DNA glycosylase 1 Rattus norvegicus 42-46 23352893-0 2013 Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure. aniline 80-87 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 51-55 23352893-2 2013 Earlier, we have shown that aniline exposure leads to oxidative DNA damage and up-regulation of OGG1 and NEIL1/2 DNA glycosylases in rat spleen. aniline 28-35 8-oxoguanine DNA glycosylase Rattus norvegicus 96-100 23352893-2 2013 Earlier, we have shown that aniline exposure leads to oxidative DNA damage and up-regulation of OGG1 and NEIL1/2 DNA glycosylases in rat spleen. aniline 28-35 nei-like DNA glycosylase 1 Rattus norvegicus 105-110 23352893-3 2013 However, the contribution of endonuclease III homolog 1 (NTH1) and apurinic/apyrimidinic endonuclease 1 (APE1) in the repair of aniline-induced oxidative DNA damage in the spleen is not known. aniline 128-135 nth-like DNA glycosylase 1 Rattus norvegicus 57-61 23352893-3 2013 However, the contribution of endonuclease III homolog 1 (NTH1) and apurinic/apyrimidinic endonuclease 1 (APE1) in the repair of aniline-induced oxidative DNA damage in the spleen is not known. aniline 128-135 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 67-103 23352893-3 2013 However, the contribution of endonuclease III homolog 1 (NTH1) and apurinic/apyrimidinic endonuclease 1 (APE1) in the repair of aniline-induced oxidative DNA damage in the spleen is not known. aniline 128-135 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 105-109 23352893-7 2013 Aniline treatment led to significant increases in NTH1- and APE1-mediated BER activity in the nuclear extracts of spleen of aniline-treated rats compared to the controls. aniline 0-7 nth-like DNA glycosylase 1 Rattus norvegicus 50-54 23352893-7 2013 Aniline treatment led to significant increases in NTH1- and APE1-mediated BER activity in the nuclear extracts of spleen of aniline-treated rats compared to the controls. aniline 0-7 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 60-64 23352893-7 2013 Aniline treatment led to significant increases in NTH1- and APE1-mediated BER activity in the nuclear extracts of spleen of aniline-treated rats compared to the controls. aniline 124-131 nth-like DNA glycosylase 1 Rattus norvegicus 50-54 23352893-7 2013 Aniline treatment led to significant increases in NTH1- and APE1-mediated BER activity in the nuclear extracts of spleen of aniline-treated rats compared to the controls. aniline 124-131 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 60-64 23352893-8 2013 NTH1 and APE1 mRNA expression in the spleen showed 2.9- and 3.2-fold increases, respectively, in aniline-treated rats compared to the controls. aniline 97-104 nth-like DNA glycosylase 1 Rattus norvegicus 0-4 23352893-8 2013 NTH1 and APE1 mRNA expression in the spleen showed 2.9- and 3.2-fold increases, respectively, in aniline-treated rats compared to the controls. aniline 97-104 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 9-13 23352893-9 2013 Likewise, Western blot analysis showed that protein expression of NTH1 and APE1 in the nuclear extracts of spleen from aniline-treated rats was 1.9- and 2.7-fold higher than the controls, respectively. aniline 119-126 nth-like DNA glycosylase 1 Rattus norvegicus 66-70 22867529-1 2013 We report here the design and synthesis of a series of 4-anilinoquinazoline derivatives, of which 7 compounds were crystallographically characterized, as epidermal growth factor receptor (EGFR) inhibitors by modifications on the aniline ring or at the 6-alkoxy site of the 6,7-dimethoxy-4-anilinoquinazoline pharmacophore. aniline 229-236 epidermal growth factor receptor Homo sapiens 154-186 22867529-1 2013 We report here the design and synthesis of a series of 4-anilinoquinazoline derivatives, of which 7 compounds were crystallographically characterized, as epidermal growth factor receptor (EGFR) inhibitors by modifications on the aniline ring or at the 6-alkoxy site of the 6,7-dimethoxy-4-anilinoquinazoline pharmacophore. aniline 229-236 epidermal growth factor receptor Homo sapiens 188-192 23352893-10 2013 Immunohistochemistry indicated that aniline treatment also led to stronger immunoreactivity for both NTH1 and APE1 in the spleens, confined to the red pulp areas. aniline 36-43 nth-like DNA glycosylase 1 Rattus norvegicus 101-105 23352893-10 2013 Immunohistochemistry indicated that aniline treatment also led to stronger immunoreactivity for both NTH1 and APE1 in the spleens, confined to the red pulp areas. aniline 36-43 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 110-114 23352893-11 2013 These results, thus, show that aniline exposure is associated with induction of NTH1 and APE1 in the spleen. aniline 31-38 nth-like DNA glycosylase 1 Rattus norvegicus 80-84 23352893-11 2013 These results, thus, show that aniline exposure is associated with induction of NTH1 and APE1 in the spleen. aniline 31-38 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 89-93 23352893-13 2013 These findings thus identify a novel mechanism through which NTH1 and APE1 may regulate the repair of oxidative DNA damage in aniline-induced splenic toxicity. aniline 126-133 nth-like DNA glycosylase 1 Rattus norvegicus 61-65 23352893-13 2013 These findings thus identify a novel mechanism through which NTH1 and APE1 may regulate the repair of oxidative DNA damage in aniline-induced splenic toxicity. aniline 126-133 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 70-74 23421678-0 2013 SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. aniline 18-25 fibroblast growth factor 2 Mus musculus 77-107 24900567-2 2013 By using aminopyrazoles as aniline bioisosteres, we discovered a novel series of LRRK2 inhibitors. aniline 27-34 leucine rich repeat kinase 2 Homo sapiens 81-86 23336999-7 2013 The activity of CYP2H and CYP3A37, enzymes involved in biotransformation in chicken, was detected by aminopyrine N-demethylation and aniline-hydroxylation assays from the microsomal suspensions. aniline 133-140 cytochrome P450 family 3 subfamily A member 5 Gallus gallus 26-33 23476457-2 2013 Further, the N-H bond is syn to the ortho-nitro group in the sulfonyl benzene ring and also syn to both the ortho- and meta-Cl atoms in the aniline ring. aniline 140-147 synemin Homo sapiens 25-28 23476457-2 2013 Further, the N-H bond is syn to the ortho-nitro group in the sulfonyl benzene ring and also syn to both the ortho- and meta-Cl atoms in the aniline ring. aniline 140-147 synemin Homo sapiens 92-95 23862618-4 2013 Similarly, quinolines possessing aniline moiety at C-4, aryl group at C-8 and oxazole ring at C-5 showed PDE4 inhibition. aniline 33-40 complement C4A (Rodgers blood group) Homo sapiens 51-54 23862618-4 2013 Similarly, quinolines possessing aniline moiety at C-4, aryl group at C-8 and oxazole ring at C-5 showed PDE4 inhibition. aniline 33-40 phosphodiesterase 4A Homo sapiens 105-109 22947025-2 2012 The anti-aflatoxin B 1 antibody was physically immobilized on gold electrodes by UV polymerization of aniline at a fixed wavelength. aniline 102-109 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 19-22 22927210-3 2012 We synthesized a new series of N-(anilinoalkyl)amides bearing 3-arylalkyloxy or 3-alkyloxy substituents at the aniline ring, looking for new potent and MT1-selective ligands. aniline 111-118 metallothionein 1I, pseudogene Homo sapiens 152-155 22905002-1 2012 In the title compound, C(12)H(9)ClN(2)O(4)S, the N-H bond in the -SO(2)-NH- segment is syn to both the ortho-nitro group in the sulfonyl-benzene ring and the ortho-Cl atom in the aniline ring. aniline 179-186 synemin Homo sapiens 87-90 23002367-8 2012 Microsomal hydroxylase activity of the cytochrome P450 2E1 (CYP2E1)-containing enzyme was measured with aniline as the substrate, and CYP2E1 expression in the liver tissue and microsome was determined by immunohistochemistry and Western blotting respectively. aniline 104-111 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 39-58 23002367-8 2012 Microsomal hydroxylase activity of the cytochrome P450 2E1 (CYP2E1)-containing enzyme was measured with aniline as the substrate, and CYP2E1 expression in the liver tissue and microsome was determined by immunohistochemistry and Western blotting respectively. aniline 104-111 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 60-66 23157194-1 2012 Sulfonamide antimicrobials (sulfamethoxazole) contain an arylamine group, oxidized by CYP2C9 to the hydroxylamine with subsequent auto-oxidation to a highly reactive [-nitroso-] intermediate is a necessary (if not sufficient) cause of drug hypersensitivity. aniline 57-66 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 86-92 21837760-2 2012 NAT1 catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. aniline 32-42 N-acetyltransferase 1 Homo sapiens 0-4 22010219-1 2012 Human arylamine N-acetyltransferase 1 (NAT1) is a phase II cytosolic enzyme responsible for the activation or deactivation of many arylamine compounds including pharmaceuticals and environmental carcinogens. aniline 6-15 N-acetyltransferase 1 Homo sapiens 39-43 22137356-2 2012 Acetylation catalysed by the NAT2 is an important process in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. aniline 85-95 N-acetyltransferase 2 Homo sapiens 29-33 21571786-7 2012 Though the girl"s raised methemoglobin levels may be explained by her history of exposure to aniline dyes, the temporal association of her methemoglobinemia related symptoms with chloroquine administration cannot be ignored. aniline 93-100 hemoglobin subunit gamma 2 Homo sapiens 25-38 22261221-5 2012 The adsorption of aniline becomes BET-type, regardless of the mobile phase composition in the tested range of the surface coverage of octadecyl ligands. aniline 18-25 delta/notch like EGF repeat containing Homo sapiens 34-37 21480221-1 2012 Cytochrome P450 1A2 (CYP1A2) is hypothesized to catalyze the activation of arylamines, known human bladder carcinogens present in cigarette smoke. aniline 75-85 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-19 21480221-1 2012 Cytochrome P450 1A2 (CYP1A2) is hypothesized to catalyze the activation of arylamines, known human bladder carcinogens present in cigarette smoke. aniline 75-85 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 21-27 22238126-8 2012 Significantly diminished interactions were seen for the aniline of APV bound in PR1 (M) and PR2 relative to the strong hydrogen bonds observed in PR1, consistent with 15- and 19-fold weaker inhibition, respectively. aniline 56-63 transmembrane protein 37 Homo sapiens 80-83 22114069-1 2012 N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. aniline 56-66 N-acetyltransferase 1 Homo sapiens 0-21 22114069-1 2012 N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. aniline 56-66 N-acetyltransferase 1 Homo sapiens 23-27 22114069-1 2012 N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. aniline 114-124 N-acetyltransferase 1 Homo sapiens 0-21 22114069-1 2012 N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. aniline 114-124 N-acetyltransferase 1 Homo sapiens 23-27 22010219-4 2012 NAT1*14B is associated with higher frequency of smoking-induced lung cancer and is the most common "slow acetylator" arylamine NAT1 genetic variant. aniline 117-126 N-acetyltransferase 1 Homo sapiens 0-4 22010219-4 2012 NAT1*14B is associated with higher frequency of smoking-induced lung cancer and is the most common "slow acetylator" arylamine NAT1 genetic variant. aniline 117-126 N-acetyltransferase 1 Homo sapiens 127-131 22219998-1 2011 In the title compound, C(12)H(7)Cl(4)NO(2)S, the N-H bond in the C-SO(2)-NH-C segment is syn with respect to the ortho-Cl atom of the sulfonyl-benzene ring and one of the meta-Cl atoms of the aniline ring. aniline 192-199 synemin Homo sapiens 89-92 22077825-4 2011 Here, we performed molecular dynamics simulations and free energy calculations on human CYP2E1 to examine the structural differences between the substrate-free and the enzymes with one and two aniline molecules bound. aniline 193-200 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 88-94 22026725-6 2011 At pH 1, where SMT(+) is predominant and the surface is positive, a major driving force is pi-pi electron donor-acceptor interaction of the protonated aniline ring with the pi-electron rich graphene surface, referred to as pi(+)-pi EDA, rather than ordinary electrostatic cation exchange. aniline 151-158 ectodysplasin A Homo sapiens 232-235 22619954-1 2011 The efficiency and the mechanism of aniline degradation by an electrochemical oxidation process using a Ti/SnO2-Sb2O5 electrode as the anode and a graphite electrode as the cathode, were studied in two aqueous electrolytes with/without Fe2+. aniline 36-43 strawberry notch homolog 1 Homo sapiens 107-110 21708182-11 2011 Furthermore, aniline exposure led to significantly increased iNOS mRNA and protein expression in the spleen, suggesting its role in increased reactive nitrogen species formation and contribution to increased nitrated proteins. aniline 13-20 nitric oxide synthase 2 Rattus norvegicus 61-65 22124984-0 2011 Formation of ionized arylamines upon electron ionization of N-aryl-methyl-isoxazole-4-carboxamides: correlation with Hammett"s constants and arylamine pKb"s mass spectra of arylmethylisoxazolecarboxamides. aniline 21-31 AKT serine/threonine kinase 1 Homo sapiens 151-154 22124984-0 2011 Formation of ionized arylamines upon electron ionization of N-aryl-methyl-isoxazole-4-carboxamides: correlation with Hammett"s constants and arylamine pKb"s mass spectra of arylmethylisoxazolecarboxamides. aniline 21-30 AKT serine/threonine kinase 1 Homo sapiens 151-154 21859124-3 2011 The method is validated by the example of the (13)C-KIE on the hydroamination of styrene with aniline, catalyzed by phosphine-ligated palladium triflates. aniline 94-101 casein kinase 1 epsilon Homo sapiens 50-55 21321790-3 2011 Acetylation catalyzed by NAT2 is an important process in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. aniline 81-91 N-acetyltransferase 2 Homo sapiens 25-29 20683028-2 2010 Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestradiol. aniline 122-132 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 21447608-1 2011 Cytochrome b(5) (b5) and NADH cytochrome b(5) reductase (b5R) detoxify reactive hydroxylamine (NHOH) metabolites of known arylamine and heterocyclic amine mammary carcinogens. aniline 122-131 cytochrome b5 type A Homo sapiens 0-15 21447608-1 2011 Cytochrome b(5) (b5) and NADH cytochrome b(5) reductase (b5R) detoxify reactive hydroxylamine (NHOH) metabolites of known arylamine and heterocyclic amine mammary carcinogens. aniline 122-131 glycoprotein hormone subunit beta 5 Homo sapiens 17-19 21447608-1 2011 Cytochrome b(5) (b5) and NADH cytochrome b(5) reductase (b5R) detoxify reactive hydroxylamine (NHOH) metabolites of known arylamine and heterocyclic amine mammary carcinogens. aniline 122-131 cytochrome b5 type A Homo sapiens 30-45 21447608-1 2011 Cytochrome b(5) (b5) and NADH cytochrome b(5) reductase (b5R) detoxify reactive hydroxylamine (NHOH) metabolites of known arylamine and heterocyclic amine mammary carcinogens. aniline 122-131 cytochrome b5 reductase 3 Homo sapiens 57-60 21317369-1 2011 Human arylamine N-acetyltransferase 2 (NAT2) mediates the biotransformation of arylamine drugs and procarcinogens into either innocuous or reactive DNA-damaging metabolites and is expressed predominantly in liver. aniline 6-15 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 39-43 21317369-10 2011 Overall, the hNAT2(tg)Nat1/2(-/-) mouse mimics human expression of NAT2 and may thus be of value in clarifying the role of human NAT2 in arylamine clearance, detoxification, and bioactivation. aniline 137-146 N-acetyltransferase 2 Homo sapiens 13-18 21070798-6 2011 Aniline treatment resulted in significant increases in splenocyte proliferation, based on cell counts, cell proliferation markers including proliferating cell nuclear antigen (PCNA), nuclear Ki67 protein (Ki67) and minichromosome maintenance (MCM), MTT assay and flow cytometric analysis. aniline 0-7 proliferating cell nuclear antigen Rattus norvegicus 140-174 21070798-6 2011 Aniline treatment resulted in significant increases in splenocyte proliferation, based on cell counts, cell proliferation markers including proliferating cell nuclear antigen (PCNA), nuclear Ki67 protein (Ki67) and minichromosome maintenance (MCM), MTT assay and flow cytometric analysis. aniline 0-7 proliferating cell nuclear antigen Rattus norvegicus 176-180 21070798-7 2011 Western blot analysis of splenocyte proteins from aniline-treated rats showed significantly increased expression of cyclins D1, D2, D3 and E, as compared to the controls. aniline 50-57 cyclin D1 Rattus norvegicus 116-140 21070798-8 2011 Similarly, real-time PCR analysis showed significantly increased mRNA expression for cyclins D1, D2, D3 and E in the spleens of aniline-treated rats. aniline 128-135 cyclin D1 Rattus norvegicus 85-109 21070798-10 2011 Our data suggest that increased expression of cyclins, CDKs and phosphorylation of pRB protein could be critical in cell proliferation, and may contribute to aniline-induced tumorigenic response in the spleen. aniline 158-165 cyclin dependent kinase 2 Rattus norvegicus 55-59 21070798-10 2011 Our data suggest that increased expression of cyclins, CDKs and phosphorylation of pRB protein could be critical in cell proliferation, and may contribute to aniline-induced tumorigenic response in the spleen. aniline 158-165 RB transcriptional corepressor 1 Rattus norvegicus 83-86 21125689-2 2011 These catalysts in the presence of nonracemic imine as an additive provided beta-amino alcohol in excellent yield (99%) and chiral purity (enantiomeric excess (ee) up to 99%) for the ARO of meso-stilbene oxide with aniline. aniline 215-222 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 183-186 21196222-8 2011 The autoxidation of o-phenylenediamine and several arylamine metabolites is accelerated in the presence of SOD or manganese, resulting in the enhancement of metal-mediated DNA damage. aniline 51-60 superoxide dismutase 1 Homo sapiens 107-110 20430842-9 2010 Our results suggest a significant role of NAT2 acetylation polymorphism in arylamine-induced cancers and are consistent with differential cancer risk and/or drug efficacy/toxicity in intermediate compared with rapid or slow NAT2 acetylator phenotypes. aniline 75-84 N-acetyltransferase 2 Homo sapiens 42-46 20549723-1 2010 An iron-based metal-organic framework, [Fe(BTC)] (BTC: 1,3,5-benzenetricarboxylate) is an efficient catalyst in the ring opening of styrene oxide with alcohols and aniline under mild reaction conditions. aniline 164-171 betacellulin Homo sapiens 43-46 20549723-1 2010 An iron-based metal-organic framework, [Fe(BTC)] (BTC: 1,3,5-benzenetricarboxylate) is an efficient catalyst in the ring opening of styrene oxide with alcohols and aniline under mild reaction conditions. aniline 164-171 betacellulin Homo sapiens 50-53 21543076-6 2011 High precision of the extraction with RSD values of 4.5-5.8% and low LOD value in a range of 0.009-0.081mug L-1 for all aniline compounds were achieved. aniline 120-127 immunoglobulin kappa variable 1-16 Homo sapiens 108-111 21529816-0 2011 Chromatographic studies of unusual on-column degradations of aniline compounds on XBridge Shield RP18 column in high pH aqueous mobile phase. aniline 61-68 pre-mRNA processing factor 3 Homo sapiens 97-101 21529816-1 2011 This paper reports unusual on-column degradations of aniline compounds on Waters XBridge Shield RP18 column when ammonium hydroxide in water and acetonitrile were used as mobile phases in liquid chromatography. aniline 53-60 pre-mRNA processing factor 3 Homo sapiens 96-100 21501579-2 2011 Diethyl and dibutyl [alpha-anilino-(quinolin-2-ylmethyl)]phosphonates (L1, L2) act as N,N-chelate ligands through the quinoline and aniline nitrogens giving complexes cis-[Pd(L1/L2)X(2)] (X Cl, Br) (1-4). aniline 132-139 CD274 molecule Homo sapiens 172-177 21441027-2 2011 Optimization of our bis-anilino-pyrimidine series of EphB4 kinase inhibitors led to the discovery of compound 12 which incorporates a key m-hydroxymethylene group on the C4 aniline. aniline 173-180 EPH receptor B4 Homo sapiens 53-58 21145906-0 2011 Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity. aniline 49-56 nei-like DNA glycosylase 1 Rattus norvegicus 13-18 21145906-0 2011 Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity. aniline 49-56 nei-like DNA glycosylase 2 Rattus norvegicus 23-28 21145906-3 2011 The base excision repair (BER) pathway is the major mechanism for the repair of oxidative DNA base lesions, and we have shown an up-regulation of 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase involved in the removal of 8-hydroxy-2"-deoxyguanosine (8-OHdG) adducts, following aniline exposure. aniline 291-298 8-oxoguanine DNA glycosylase Rattus norvegicus 146-172 21145906-3 2011 The base excision repair (BER) pathway is the major mechanism for the repair of oxidative DNA base lesions, and we have shown an up-regulation of 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase involved in the removal of 8-hydroxy-2"-deoxyguanosine (8-OHdG) adducts, following aniline exposure. aniline 291-298 8-oxoguanine DNA glycosylase Rattus norvegicus 174-178 21145906-5 2011 However, contribution of NEIL1/2 in the repair of aniline-induced oxidative DNA damage in the spleen is not known. aniline 50-57 nei-like DNA glycosylase 1 Rattus norvegicus 25-32 21145906-9 2011 Aniline treatment led to a 1.25-fold increase in the NEIL1/2-associated BER activity in the nuclear extracts of spleen compared to the controls. aniline 0-7 nei-like DNA glycosylase 1 Rattus norvegicus 53-58 21145906-10 2011 Real-time PCR analysis for NEIL1 and NEIL2 mRNA expression in the spleen revealed 2.7- and 3.9-fold increases, respectively, in aniline-treated rats compared to controls. aniline 128-135 nei-like DNA glycosylase 1 Rattus norvegicus 27-32 21145906-10 2011 Real-time PCR analysis for NEIL1 and NEIL2 mRNA expression in the spleen revealed 2.7- and 3.9-fold increases, respectively, in aniline-treated rats compared to controls. aniline 128-135 nei-like DNA glycosylase 2 Rattus norvegicus 37-42 21145906-11 2011 Likewise, Western blot analysis showed that protein expression of NEIL1 and NEIL2 in the nuclear extract of spleens from aniline-treated rats was 2.0- and 3.8-fold higher than controls, respectively. aniline 121-128 nei-like DNA glycosylase 1 Rattus norvegicus 66-71 21145906-11 2011 Likewise, Western blot analysis showed that protein expression of NEIL1 and NEIL2 in the nuclear extract of spleens from aniline-treated rats was 2.0- and 3.8-fold higher than controls, respectively. aniline 121-128 nei-like DNA glycosylase 2 Rattus norvegicus 76-81 21145906-12 2011 Aniline treatment also led to stronger immunoreactivity for NEIL1 and NEIL2 in the spleens, confined to the red pulp areas. aniline 0-7 nei-like DNA glycosylase 1 Rattus norvegicus 60-65 21145906-12 2011 Aniline treatment also led to stronger immunoreactivity for NEIL1 and NEIL2 in the spleens, confined to the red pulp areas. aniline 0-7 nei-like DNA glycosylase 2 Rattus norvegicus 70-75 21145906-13 2011 These studies, thus, show that aniline-induced oxidative stress is associated with an induction of NEIL1/2. aniline 31-38 nei-like DNA glycosylase 1 Rattus norvegicus 99-106 21347396-1 2011 Arylamine N-acetyltransferase-1 (NAT1) is an enzyme that catalyzes the biotransformation of arylamine and hydrazine substrates. aniline 92-101 N-acetyltransferase 1 Homo sapiens 0-31 21347396-1 2011 Arylamine N-acetyltransferase-1 (NAT1) is an enzyme that catalyzes the biotransformation of arylamine and hydrazine substrates. aniline 92-101 N-acetyltransferase 1 Homo sapiens 33-37 21177105-1 2011 A novel series of 5-((4-aminopiperidin-1-yl)methyl)-pyrrolo[2,1-f][1,2,4]triazin-4-amines with small aniline substituents at the C4 position were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. aniline 101-108 epidermal growth factor receptor Homo sapiens 165-169 21177105-1 2011 A novel series of 5-((4-aminopiperidin-1-yl)methyl)-pyrrolo[2,1-f][1,2,4]triazin-4-amines with small aniline substituents at the C4 position were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. aniline 101-108 erb-b2 receptor tyrosine kinase 2 Homo sapiens 174-178 20683028-2 2010 Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestradiol. aniline 122-132 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 20683028-2 2010 Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestradiol. aniline 122-132 N-acetyltransferase 2 Homo sapiens 33-53 20683028-2 2010 Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestradiol. aniline 122-132 N-acetyltransferase 2 Homo sapiens 55-59 20683028-2 2010 Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestradiol. aniline 122-132 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 158-164 21587870-1 2010 In the title compound, C(12)H(8)Cl(3)NO(2)S, the conformation of the N-H bond in the C-SO(2)-NH-C segment is syn to the ortho-Cl in the aniline ring. aniline 136-143 synemin Homo sapiens 109-112 20433335-2 2010 The arylamine, 4-aminobiphenyl (4-ABP), has been identified as a human carcinogen. aniline 4-13 amine oxidase copper containing 1 Homo sapiens 34-37 20438078-3 2010 That is, aldehyde-substituted guests within the CdL(2) host become "stable" in the aniline phase and vice versa. aniline 83-90 Cornelia de Lange syndrome 2 Homo sapiens 48-53 20408528-1 2010 The CuX (X = I, Br, Cl, CN)-mediated cyclization-halogenation and cyclization-cyanation reactions of beta-hydroxyalkynes and o-alkynylphenol and -aniline derivatives give rise to 3-halo- and 3-cyanofuro[3,2-b]pyrroles, 3-iodo-, 3-bromo-, and 3-cyanobenzofurans, and 3-cyanoindoles, respectively. aniline 146-153 cut like homeobox 1 Homo sapiens 4-7 20199096-4 2010 Immunoassay experiments using the immuno-spin-trapping technique were performed, which evaluated the potency of different aromatic amines containing the aniline substructure to generate the MPO*. aniline 153-160 myeloperoxidase Homo sapiens 190-194 20199096-6 2010 Several physicochemical parameters for aniline derivatives were used to derive quantitative structure-activity relationship equations, which showed that the Hammett constant (sigma) best correlated with the MPO* formation for all aniline derivatives. aniline 39-46 myeloperoxidase Homo sapiens 207-210 20199096-6 2010 Several physicochemical parameters for aniline derivatives were used to derive quantitative structure-activity relationship equations, which showed that the Hammett constant (sigma) best correlated with the MPO* formation for all aniline derivatives. aniline 230-237 myeloperoxidase Homo sapiens 207-210 20199096-10 2010 Interestingly, we found that only those aniline derivatives that produced a phenyl radical also formed MPO*. aniline 40-47 myeloperoxidase Homo sapiens 103-106 20165802-0 2010 Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil. aniline 83-90 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 120-124 20050608-14 2010 In 0.1 M BSA, PAN molecules produced by small overpotential (eta < 100 mV) could assume linear chains or 3D aggregates, depending on [aniline]. aniline 137-144 endothelin receptor type A Homo sapiens 61-64 20233944-7 2010 However, mild to moderate anti-CNPase staining extended to the swollen cytoplasm of the oligodendroglia in the aniline-treated rats from day 2 to day 4. aniline 111-118 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 31-37 20233944-11 2010 The reduction in CNPase expression may contribute to the changes in the myelin morphology observed in aniline intoxication. aniline 102-109 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 17-23 20060283-1 2010 A novel catechol biosensor was described based on the immobilization of polyphenol oxidase (PPO) into polyaniline (PANI), which was easily constructed by direct electropolymerization of aniline in a solution containing ionic liquid, 1-ethyl-3-methylimidazolium ethyl sulfate (EMIES). aniline 106-113 protoporphyrinogen oxidase Homo sapiens 72-90 20060283-1 2010 A novel catechol biosensor was described based on the immobilization of polyphenol oxidase (PPO) into polyaniline (PANI), which was easily constructed by direct electropolymerization of aniline in a solution containing ionic liquid, 1-ethyl-3-methylimidazolium ethyl sulfate (EMIES). aniline 106-113 protoporphyrinogen oxidase Homo sapiens 92-95 20028072-5 2009 Correspondingly, the formation rate for the reduction product aniline was 1.14 +/- 0.03 mol m(-3) TCC d(-1). aniline 62-69 sideroflexin 1 Homo sapiens 98-101 19969074-0 2010 Up-regulation of heme oxygenase-1 in rat spleen after aniline exposure. aniline 54-61 heme oxygenase 1 Rattus norvegicus 17-33 19969074-6 2010 Aniline exposure led to significant increases in HO-1 mRNA expression in the spleen (2-and 2.4-fold at days 4 and 7, respectively) with corresponding increases in protein expression, as confirmed by ELISA and Western blot analysis. aniline 0-7 heme oxygenase 1 Rattus norvegicus 49-53 19969074-9 2010 The increase in HO-1 expression was associated with increases in total iron (2.4-and 2.7-fold), free iron (1.9-and 3.5-fold), and ferritin levels (1.9-and 2.1-fold) at 4 and 7 days of aniline exposure. aniline 184-191 heme oxygenase 1 Rattus norvegicus 16-20 19969074-10 2010 Our data suggest that HO-1 up-regulation in aniline-induced splenic toxicity could be a contributing pro-oxidant mechanism, mediated through iron release, and leading to oxidative damage. aniline 44-51 heme oxygenase 1 Rattus norvegicus 22-26 20609902-7 2010 With the use of this method, we found that conversion of the Sec residue at the active site of GPx1 to DHA occurred during aging of red blood cells (RBCs) in vivo as well as in RBCs exposed to H(2)O(2) generated either externally by glucose oxidase or internally as a result of aniline-induced Hb autoxidation. aniline 278-285 glutathione peroxidase 1 Homo sapiens 95-99 21387795-11 2010 First of them regards a 21-year-old woman with the methemoglobin level of 38.3% induced by accidental inhalation exposure to aniline. aniline 125-132 hemoglobin subunit gamma 2 Homo sapiens 51-64 19842618-1 2009 Human arylamine N-acetyltransferases (NATs) are expressed as two polymorphic isoforms, NAT1 and NAT2, that have toxicologically significant functions in the detoxification of xenobiotic arylamines by N-acetylation and in the bioactivation of N-arylhydroxylamines by O-acetylation. aniline 186-196 N-acetyltransferase 1 Homo sapiens 87-91 19842618-1 2009 Human arylamine N-acetyltransferases (NATs) are expressed as two polymorphic isoforms, NAT1 and NAT2, that have toxicologically significant functions in the detoxification of xenobiotic arylamines by N-acetylation and in the bioactivation of N-arylhydroxylamines by O-acetylation. aniline 186-196 N-acetyltransferase 2 Homo sapiens 96-100 19842618-3 2009 On the basis of earlier studies with hamster NAT1, hamster NAT2, and human NAT1, we proposed that human NAT2 would be more susceptible than NAT1 to inactivation by N-arylhydroxamic acid metabolites of arylamines. aniline 201-211 N-acetyltransferase 1 Homo sapiens 75-79 19842618-3 2009 On the basis of earlier studies with hamster NAT1, hamster NAT2, and human NAT1, we proposed that human NAT2 would be more susceptible than NAT1 to inactivation by N-arylhydroxamic acid metabolites of arylamines. aniline 201-211 N-acetyltransferase 2 Homo sapiens 104-108 19842618-3 2009 On the basis of earlier studies with hamster NAT1, hamster NAT2, and human NAT1, we proposed that human NAT2 would be more susceptible than NAT1 to inactivation by N-arylhydroxamic acid metabolites of arylamines. aniline 201-211 N-acetyltransferase 1 Homo sapiens 75-79 19842618-11 2009 Because of its wide distribution in human tissues and its early expression in developing tissues, the apparent high sensitivity of intracellular NAT1 to inactivation by reactive metabolites of environmental arylamines may have important toxicological consequences. aniline 207-217 N-acetyltransferase 1 Homo sapiens 145-149 20028072-6 2009 Nitrobenzene removal and aniline formation rates were significantly enhanced when the BES was supplied with power, reaching 8.57 +/- 0.03 and 6.68 +/- 0.03 mol m(-3) TCC d(-1), respectively, at an energy consumption of 17.06 +/- 0.16 W m(-3) TCC (current density at 59.5 A m(-3) TCC). aniline 25-32 sideroflexin 1 Homo sapiens 166-169 19570609-1 2009 Three different polymers P1, P2 and P3 (P1 containing both beta-CD and -COOH, P2 containing beta-CD and P3 containing -COOH) were synthesized and applied to adsorption toward aniline, 1-naphthylamine and methylene blue. aniline 175-182 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) Homo sapiens 25-38 18608262-1 2009 INTRODUCTION: p-Chloroaniline is more potent at producing methemoglobin than aniline in animal models. aniline 22-29 hemoglobin subunit gamma 2 Homo sapiens 58-71 21583652-3 2009 The conformation of the N-H bond is syn to the 3-chloro group in the substituted aniline ring. aniline 81-88 synemin Homo sapiens 36-39 21583670-1 2009 The conformation of the N-H bond in the structure of the title compound, C(8)H(7)BrClNO, is syn to the 2-chloro substituent in the aniline ring and anti to both the C=O and C-Br bonds in the side chain, similar to that observed in 2-chloro-N-(2-chloro-phen-yl)acetamide. aniline 131-138 synemin Homo sapiens 92-95 19673510-1 2009 The electropolymerization of aniline-functionalized carbon nanotubes (CNTs) and thioaniline-modified glucose oxidase (GOx) on a thioaniline monolayer-modified Au electrode yields a CNTs/GOx composite cross-linked by the redox-active bis-aniline units. aniline 29-36 hydroxyacid oxidase 1 Homo sapiens 186-189 19683030-10 2009 Thiopronin concentration-dependently inhibited CYP2E1-dependent aniline hydroxylation, and the Dixon plots suggest that thiopronin is a competitive inhibitor of CYP2E1. aniline 64-71 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 47-53 19774253-1 2009 In situ STM imaging of Au(100) electrode in 1 M HClO4 + 0.03 M aniline revealed highly ordered aniline adlattices of (2 radical 2 x 4 radical 2)R45 degrees and (radical 10 x radical 10)R18 degrees and polyaniline molecules exhibiting wiggling conformations at potentials negative and positive of 0.95 V (vs. reversible hydrogen electrode), respectively. aniline 63-70 sulfotransferase family 1A member 3 Homo sapiens 8-11 19774253-1 2009 In situ STM imaging of Au(100) electrode in 1 M HClO4 + 0.03 M aniline revealed highly ordered aniline adlattices of (2 radical 2 x 4 radical 2)R45 degrees and (radical 10 x radical 10)R18 degrees and polyaniline molecules exhibiting wiggling conformations at potentials negative and positive of 0.95 V (vs. reversible hydrogen electrode), respectively. aniline 95-102 sulfotransferase family 1A member 3 Homo sapiens 8-11 19846948-14 2009 We hypothesize that arylesterase activity of PON1 would help the formation of free-radical type arylamine derivates on the bladder epithelial surface, so that secondary metabolites of paraoxon or related chemicals and biotransformed intermediates of arylamines might be involved in formation of bladder carcinoma. aniline 96-105 paraoxonase 1 Homo sapiens 45-49 19459732-6 2009 Treatment of mice with AF significantly and dose-dependently reduced CYP2E1-dependent aniline hydroxylation and CYP2E1 protein levels. aniline 86-93 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 69-75 19151371-1 2009 When positioned opposite to a dA in a DNA duplex, the prototype arylamine-DNA adduct [N-(2"-deoxyguanosin-yl)-7-fluoro-2-aminofluorene (FAF)] adopts the so-called "wedge" (W) conformation, in which the carcinogen resides in the minor groove of the duplex. aniline 64-73 ubiquitin specific peptidase 9 X-linked Homo sapiens 136-139 18976900-1 2009 A novel polyaniline-ionic liquid-carbon nanofiber (PANI-IL-CNF) composite was greenly prepared by in situ one-step electropolymerization of aniline in the presence of IL and CNF for fabrication of amperometric biosensors. aniline 12-19 NPHS1 adhesion molecule, nephrin Homo sapiens 59-62 18976900-1 2009 A novel polyaniline-ionic liquid-carbon nanofiber (PANI-IL-CNF) composite was greenly prepared by in situ one-step electropolymerization of aniline in the presence of IL and CNF for fabrication of amperometric biosensors. aniline 12-19 NPHS1 adhesion molecule, nephrin Homo sapiens 167-177 19208477-0 2009 Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors. aniline 28-35 epidermal growth factor receptor Homo sapiens 81-85 19208477-0 2009 Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors. aniline 28-35 erb-b2 receptor tyrosine kinase 2 Homo sapiens 86-92 19208477-1 2009 Aniline "headgroups" were synthesized and incorporated into an alkynyl thienopyrimidine series of EGFR and ErbB-2 inhibitors. aniline 0-7 epidermal growth factor receptor Homo sapiens 98-102 19208477-1 2009 Aniline "headgroups" were synthesized and incorporated into an alkynyl thienopyrimidine series of EGFR and ErbB-2 inhibitors. aniline 0-7 erb-b2 receptor tyrosine kinase 2 Homo sapiens 107-113 18680467-1 2008 Arylamine N-acetyltransferase 2 (NAT2) modifies drug efficacy/toxicity and cancer risk due to its role in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. aniline 142-151 N-acetyltransferase 2 Homo sapiens 0-31 20183529-1 2009 N-Acetyltransferases (NAT) are key enzymes in the conjugation of certain drugs and other xenobiotics with an arylamine structure. aniline 109-118 bromodomain containing 2 Homo sapiens 0-20 20183529-1 2009 N-Acetyltransferases (NAT) are key enzymes in the conjugation of certain drugs and other xenobiotics with an arylamine structure. aniline 109-118 bromodomain containing 2 Homo sapiens 22-25 18842621-9 2009 These studies clearly show NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in rat mammary epithelial cell cultures to be subject to downregulation by the arylamine carcinogen ABP. aniline 209-218 N-acetyltransferase 2 Rattus norvegicus 27-31 18842621-9 2009 These studies clearly show NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in rat mammary epithelial cell cultures to be subject to downregulation by the arylamine carcinogen ABP. aniline 209-218 glutamate receptor interacting protein 2 Rattus norvegicus 230-233 18793663-7 2008 DNA repair activity, measured as OGG1 base excision repair (BER) activity, increased by approximately 1.3 fold in the nuclear protein extracts (NE) and approximately 1.2 fold in the mitochondrial protein extracts (ME) of spleens from aniline-treated rats as compared to the controls. aniline 234-241 8-oxoguanine DNA glycosylase Rattus norvegicus 33-37 18793663-8 2008 Real-time PCR analysis for OGG1 mRNA expression in the spleen revealed a 2-fold increase in expression in aniline-treated rats than the controls. aniline 106-113 8-oxoguanine DNA glycosylase Rattus norvegicus 27-31 18793663-9 2008 Likewise, OGG1 protein expression in the NEs of spleens from aniline-treated rats was approximately 1.5 fold higher, whereas in the MEs it was approximately 1.3 fold higher than the controls. aniline 61-68 8-oxoguanine DNA glycosylase Rattus norvegicus 10-14 18793663-10 2008 Aniline treatment also led to stronger immunostaining for both 8-OHdG and OGG1 in the spleens, confined to the red pulp areas. aniline 0-7 8-oxoguanine DNA glycosylase Rattus norvegicus 74-78 18975893-7 2008 It was observed by atomic force microscopy (AFM) that the PANI-modified PET surface exhibits higher size irregularity and surface roughness, which further indicated that a much greater number of aniline molecules can be reactively bonded to and distributed along the grafted AAc chains and that the PANI-g-PAAc-g-PET surface resulting from the sequential oxidative graft copolymerization can possess higher electrical conductivity. aniline 195-202 glycine-N-acyltransferase Homo sapiens 275-278 18613668-11 2008 In contrast, ion pair 5 does not spontaneously undergo remetalation of the naphthyl moiety; it reacts with NMe2Ph leading to [MeHf{N(-),N}NMe2C6H4][B(C6F5)4] (7) through ortho-metalation of the aniline. aniline 194-201 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 107-111 18420242-5 2008 Significant increases in both NF-kappaB and AP-1 binding activity was observed in the nuclear extracts of splenocytes from aniline-treated rats as determined by ELISAs, and supported by Western blot data showing increases in p-IkappaBalpha, p-p65 and p-c-Jun. aniline 123-130 NFKB inhibitor alpha Rattus norvegicus 227-239 18420242-5 2008 Significant increases in both NF-kappaB and AP-1 binding activity was observed in the nuclear extracts of splenocytes from aniline-treated rats as determined by ELISAs, and supported by Western blot data showing increases in p-IkappaBalpha, p-p65 and p-c-Jun. aniline 123-130 synaptotagmin 1 Rattus norvegicus 243-246 18420242-7 2008 Our data showed remarkable increases in both p-IKKalpha and p-IKKbeta in the splenocytes from aniline-treated rats, suggesting their role in the phosphorylation of both IkappaBalpha and p65 subunits. aniline 94-101 component of inhibitor of nuclear factor kappa B kinase complex Rattus norvegicus 47-55 18420242-7 2008 Our data showed remarkable increases in both p-IKKalpha and p-IKKbeta in the splenocytes from aniline-treated rats, suggesting their role in the phosphorylation of both IkappaBalpha and p65 subunits. aniline 94-101 inhibitor of nuclear factor kappa B kinase subunit beta Rattus norvegicus 62-69 18420242-7 2008 Our data showed remarkable increases in both p-IKKalpha and p-IKKbeta in the splenocytes from aniline-treated rats, suggesting their role in the phosphorylation of both IkappaBalpha and p65 subunits. aniline 94-101 NFKB inhibitor alpha Rattus norvegicus 169-181 18420242-7 2008 Our data showed remarkable increases in both p-IKKalpha and p-IKKbeta in the splenocytes from aniline-treated rats, suggesting their role in the phosphorylation of both IkappaBalpha and p65 subunits. aniline 94-101 synaptotagmin 1 Rattus norvegicus 186-189 18420242-8 2008 Furthermore, aniline exposure led to activation of all three classes of MAPKs, as evident from increased phosphorylation of extracellular-signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK1/2) and p38 MAPKs, which could potentially contribute to the observed activation of both AP-1 and NF-kappaB. aniline 13-20 mitogen activated protein kinase 3 Rattus norvegicus 163-169 18420242-8 2008 Furthermore, aniline exposure led to activation of all three classes of MAPKs, as evident from increased phosphorylation of extracellular-signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK1/2) and p38 MAPKs, which could potentially contribute to the observed activation of both AP-1 and NF-kappaB. aniline 13-20 mitogen activated protein kinase 14 Rattus norvegicus 209-212 18560660-5 2008 This mass spectrometric behavior puts the radical cation 2(*+) in between the fragmentation reactions of aniline radical cation 1(*+) (loss of H and subsequent losses of C(2)H(2,) or HCN) and phenyl arsane radical cation 3(*+) (elimination of H(2) and loss of As from ion [M-H](+)). aniline 105-112 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 183-186 18977146-4 2008 In view of the above results, the aniline ring of 3 was replaced by 2,6-dimethyl aniline to increase the potency for LCK kinase. aniline 34-41 LCK proto-oncogene, Src family tyrosine kinase Homo sapiens 117-120 18799801-11 2008 These congenic rat lines are useful for investigating the role of NAT2 genetic polymorphisms in susceptibility to cancers related to arylamine carcinogen exposures. aniline 133-142 N-acetyltransferase 2 Rattus norvegicus 66-70 18799802-9 2008 These measures of rat Nat expression confirm that Nat3 expression is negligible and that Nat1 and Nat2 are the primary determinants of arylamine acetylation activity in all tissues tested. aniline 135-144 N-acetyltransferase 1 Rattus norvegicus 89-93 18799802-9 2008 These measures of rat Nat expression confirm that Nat3 expression is negligible and that Nat1 and Nat2 are the primary determinants of arylamine acetylation activity in all tissues tested. aniline 135-144 N-acetyltransferase 2 Rattus norvegicus 98-102 18759501-4 2008 The arylamine N-acetyltransferases, NAT1 and NAT2, catalyze N-acetylation of arylamines and play central roles in their detoxification. aniline 77-87 N-acetyltransferase 1 Homo sapiens 36-40 18759501-4 2008 The arylamine N-acetyltransferases, NAT1 and NAT2, catalyze N-acetylation of arylamines and play central roles in their detoxification. aniline 77-87 N-acetyltransferase 2 Homo sapiens 45-49 18511294-1 2008 This study demonstrates the application of 2,5-dihydrohybenzoic acid/aniline (DHB/An) and 2,5-dihydroxybenzoic acid/N,N-dimethylaniline (DHB/DMA) matrices for automated identification and quantitative analysis of native oligosaccharides by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). aniline 69-76 DNA helicase B Homo sapiens 78-81 18680467-1 2008 Arylamine N-acetyltransferase 2 (NAT2) modifies drug efficacy/toxicity and cancer risk due to its role in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. aniline 142-151 N-acetyltransferase 2 Homo sapiens 33-37 21203140-2 2008 Furthermore, the conformation of the N-H bond is syn to the ortho-chloro group in the aniline ring and the C=O bond is syn to the ortho-methyl substituent in the benzoyl ring, similar to what is observed in 2-chloro-N-(2-chloro-phen-yl)benzamide and 2-methyl-N-phenyl-benzamide. aniline 86-93 synemin Homo sapiens 49-52 17698408-6 2008 Cyclic voltammograms show an irreversible reduction of Co(III) in DMF using Glassy Carbon Electrode, GCE, the redox peaks for the aniline complexes appear at -0.20 and 0.525V. aniline 130-137 mitochondrially encoded cytochrome c oxidase III Homo sapiens 55-62 18680467-9 2008 This analysis advances understanding of NAT2 structure-function relationships, important for interpreting the role of NAT2 genetic polymorphisms in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. aniline 184-193 N-acetyltransferase 2 Homo sapiens 40-44 18680467-9 2008 This analysis advances understanding of NAT2 structure-function relationships, important for interpreting the role of NAT2 genetic polymorphisms in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. aniline 184-193 N-acetyltransferase 2 Homo sapiens 118-122 18680470-1 2008 Arylamine N-acetyltransferases (NAT) are xenobiotic-metabolizing enzymes responsible for the acetylation of many aromatic arylamine and heterocyclic amines, thereby playing an important role in both detoxification and activation of numerous drugs and carcinogens. aniline 122-131 bromodomain containing 2 Homo sapiens 10-30 18680470-1 2008 Arylamine N-acetyltransferases (NAT) are xenobiotic-metabolizing enzymes responsible for the acetylation of many aromatic arylamine and heterocyclic amines, thereby playing an important role in both detoxification and activation of numerous drugs and carcinogens. aniline 122-131 bromodomain containing 2 Homo sapiens 32-35 18494457-4 2008 In the headpiece of the 4-(phenylaminomethylene)isoquinoline-1,3(2H,4H)-dione, a basic amine substituent is required on the aniline ring for the CDK4 inhibitory activity. aniline 124-131 cyclin dependent kinase 4 Homo sapiens 145-149 18436364-7 2008 Treatment with CAPE significantly decreased the CYP2E1-dependent hydroxylation of aniline. aniline 82-89 structural maintenance of chromosomes 2 Mus musculus 15-19 18436364-7 2008 Treatment with CAPE significantly decreased the CYP2E1-dependent hydroxylation of aniline. aniline 82-89 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 48-54 18288399-1 2008 Arylamine N-acetyltransferase type 1 (NAT1) is reported to be involved in the transfer of an acetyl group from acetyl-CoA to the terminal nitrogen of hydrazine and arylamine drugs or carcinogens. aniline 164-173 N-acetyltransferase 1 Homo sapiens 38-42 18595693-0 2008 Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists. aniline 27-34 complement C5a receptor 1 Homo sapiens 67-79 18595693-1 2008 A series of aniline-substituted tetrahydroquinoline C5a receptor antagonists were discovered. aniline 12-19 complement C5a receptor 1 Homo sapiens 52-64 18291569-8 2008 Treatment with CKS resulted in a significant decrease in the CYP2E1-dependent hydroxylation of aniline. aniline 95-102 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 61-67 18308702-1 2008 Cytochrome P450 1B1 (CYP1B1) is a heme-containing monooxygenase that metabolizes various polycyclic aromatic hydrocarbons and aryl amines, as well as retinoic acid and steroid hormones. aniline 126-137 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 0-19 18308702-1 2008 Cytochrome P450 1B1 (CYP1B1) is a heme-containing monooxygenase that metabolizes various polycyclic aromatic hydrocarbons and aryl amines, as well as retinoic acid and steroid hormones. aniline 126-137 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 21-27 18052314-2 2007 MT1 and MT2 receptor binding affinity and intrinsic activity have been modulated by the introduction of different substituents on the aniline nitrogen, on the benzene ring, and on the amide side chain. aniline 134-141 metallothionein 1I, pseudogene Homo sapiens 0-3 18189370-0 2008 Electrochemical genotoxicity screening for arylamines bioactivated by N-acetyltransferase. aniline 43-53 bromodomain containing 2 Homo sapiens 70-89 18189370-8 2008 DNA damage occurred more rapidly under weakly acidic conditions (pH 5.5-5.8) than at neutral pH, suggesting that genotoxicity from arylamine metabolism by NAT could be more significant in slightly acidic environments. aniline 131-140 bromodomain containing 2 Homo sapiens 155-158 18027981-6 2007 The photoexcited state Ru(II*) of Ru2Z is reduced to Ru(I) by the sacrificial electron donor aniline, and Ru(I) then reduces CuA with yields up to 60%. aniline 93-100 doublecortin domain containing 2 Homo sapiens 34-37 18043127-2 2008 Amonafide contains a free arylamine, which causes it to be metabolized in humans by N-acetyl transferase-2 (NAT2) into a toxic form. aniline 26-35 N-acetyltransferase 2 Homo sapiens 84-106 18043127-2 2008 Amonafide contains a free arylamine, which causes it to be metabolized in humans by N-acetyl transferase-2 (NAT2) into a toxic form. aniline 26-35 N-acetyltransferase 2 Homo sapiens 108-112 18259988-2 2008 NAT1 both activates and deactivates arylamine drugs and carcinogens, and NAT1 polymorphisms are associated with increased frequencies of many cancers and birth defects. aniline 36-45 N-acetyltransferase 1 Homo sapiens 0-4 18156308-1 2008 Since recombinant human cyclooxygenase (COX) enzymes have been shown to activate environmental and dietary carcinogens implicated in human colorectal cancer etiology, we hypothesized that COX-2 inhibitors reduce arylamine-induced aberrant crypts (AC) and foci (ACF), preneoplastic lesions of colorectal cancer. aniline 212-221 mitochondrially encoded cytochrome c oxidase II Homo sapiens 188-193 17921302-6 2007 Here we report the use of bioinformatic and biochemical tools to identify and characterize the reductase component (PrnF) involved in the PrnD-catalyzed unusual arylamine oxidation. aniline 161-170 prion like protein doppel Homo sapiens 138-142 18089707-4 2007 Prodrug 1 is a good substrate for purified NQO1 (V(max) and K(m) values of 11.86 +/- 3.09 micromol/min/mg and 2.70 +/- 1.14 micromol/L, respectively) and liquid chromatography-mass spectrometry analysis of the metabolites generated showed that lactone 3 and aniline mustard 4 were generated in a time- and NQO1-dependent manner. aniline 258-265 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-47 18045063-10 2007 It has been observed that aniline group at C-4, aminoacrylamide substituents at C-6, cyano group at C-3 and alkoxy groups at C-7 in the quinoline ring play an important role for optimal activity. aniline 26-33 complement C4A (Rodgers blood group) Homo sapiens 43-46 18045063-10 2007 It has been observed that aniline group at C-4, aminoacrylamide substituents at C-6, cyano group at C-3 and alkoxy groups at C-7 in the quinoline ring play an important role for optimal activity. aniline 26-33 complement C6 Homo sapiens 80-83 18045063-10 2007 It has been observed that aniline group at C-4, aminoacrylamide substituents at C-6, cyano group at C-3 and alkoxy groups at C-7 in the quinoline ring play an important role for optimal activity. aniline 26-33 complement C3 Homo sapiens 100-103 18045063-10 2007 It has been observed that aniline group at C-4, aminoacrylamide substituents at C-6, cyano group at C-3 and alkoxy groups at C-7 in the quinoline ring play an important role for optimal activity. aniline 26-33 complement C7 Homo sapiens 125-128 17590492-4 2007 Treatment of the mice with kahweol and cafestol also resulted in a significant decrease in the cytochrome P450 2E1 (CYP2E1), the major isozyme involved in CCl(4) bioactivation, specific enzyme activities, such as p-nitrophenol and aniline hydroxylation. aniline 231-238 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 95-114 17590492-4 2007 Treatment of the mice with kahweol and cafestol also resulted in a significant decrease in the cytochrome P450 2E1 (CYP2E1), the major isozyme involved in CCl(4) bioactivation, specific enzyme activities, such as p-nitrophenol and aniline hydroxylation. aniline 231-238 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 116-122 18153996-7 2007 Rate constants for photodegradation of benzylamine and aniline were found to be 1.4 x 10(-3) min(-1) and 0.7 x 10(-3) min(-1) for TiO2 as photocatalyst, while 2.7 x 10(-3) min(-1) and 1.7 x 10(-3) min(-1) for (5 wt.%) Pt/TiO2 as photocatalyst. aniline 55-62 CD59 molecule (CD59 blood group) Homo sapiens 93-99 18153996-7 2007 Rate constants for photodegradation of benzylamine and aniline were found to be 1.4 x 10(-3) min(-1) and 0.7 x 10(-3) min(-1) for TiO2 as photocatalyst, while 2.7 x 10(-3) min(-1) and 1.7 x 10(-3) min(-1) for (5 wt.%) Pt/TiO2 as photocatalyst. aniline 55-62 CD59 molecule (CD59 blood group) Homo sapiens 118-124 18153996-7 2007 Rate constants for photodegradation of benzylamine and aniline were found to be 1.4 x 10(-3) min(-1) and 0.7 x 10(-3) min(-1) for TiO2 as photocatalyst, while 2.7 x 10(-3) min(-1) and 1.7 x 10(-3) min(-1) for (5 wt.%) Pt/TiO2 as photocatalyst. aniline 55-62 CD59 molecule (CD59 blood group) Homo sapiens 118-124 18153996-7 2007 Rate constants for photodegradation of benzylamine and aniline were found to be 1.4 x 10(-3) min(-1) and 0.7 x 10(-3) min(-1) for TiO2 as photocatalyst, while 2.7 x 10(-3) min(-1) and 1.7 x 10(-3) min(-1) for (5 wt.%) Pt/TiO2 as photocatalyst. aniline 55-62 CD59 molecule (CD59 blood group) Homo sapiens 118-124 18052314-2 2007 MT1 and MT2 receptor binding affinity and intrinsic activity have been modulated by the introduction of different substituents on the aniline nitrogen, on the benzene ring, and on the amide side chain. aniline 134-141 metallothionein 2A Homo sapiens 8-11 18038910-8 2007 Treatment of the mice with puerarin resulted in a significant decrease in the CYP2E1-dependent aniline hydroxylation in a dose-dependent manner. aniline 95-102 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 78-84 17672512-0 2007 Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2. aniline 124-134 N-acetyltransferase 1 Homo sapiens 146-150 17567587-1 2007 Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens. aniline 6-15 N-acetyltransferase 1 Rattus norvegicus 37-41 17567587-1 2007 Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens. aniline 6-15 N-acetyltransferase 2 Rattus norvegicus 46-50 17672512-0 2007 Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2. aniline 124-134 N-acetyltransferase 2 Homo sapiens 155-159 17672512-5 2007 The kinetic specificity constants ( k cat/ K m) for N-acetylation of arylamine environmental contaminants, some of which are associated with bladder cancer risk, were determined with NAT2 and NAT1. aniline 69-78 N-acetyltransferase 2 Homo sapiens 183-187 17672512-5 2007 The kinetic specificity constants ( k cat/ K m) for N-acetylation of arylamine environmental contaminants, some of which are associated with bladder cancer risk, were determined with NAT2 and NAT1. aniline 69-78 N-acetyltransferase 1 Homo sapiens 192-196 17636946-2 2007 Efficient array and interative synthesis of triazoles led to rapid SAR development around the aniline, benzylthio, and triazole moeities. aniline 94-101 sarcosine dehydrogenase Homo sapiens 67-70 17636946-6 2007 Key aniline (2-isopropylphenyl) and sulfur substituents (furanylmethyl) identified in the SAR studies led to the identification of potent inhibitors (103 and 104) of endothelial cell proliferation. aniline 4-11 sarcosine dehydrogenase Homo sapiens 90-93 17434872-8 2007 The chemical identity and position of the substituents on the lower aniline ring were important in determining the potency and extent of COX inhibition as well as COX-2 selectivity. aniline 68-75 mitochondrially encoded cytochrome c oxidase II Homo sapiens 163-168 16397907-2 2007 Human arylamine NATs are known to exist as two isoenzymes, NAT1 and NAT2. aniline 6-15 N-acetyltransferase 1 Homo sapiens 59-63 16397907-2 2007 Human arylamine NATs are known to exist as two isoenzymes, NAT1 and NAT2. aniline 6-15 N-acetyltransferase 2 Homo sapiens 68-72 17403913-4 2007 Whereas Nat1 and Nat2 can efficiently acetylate many arylamines, few substrates appear to be appreciably metabolized by Nat3. aniline 53-63 N-acetyl transferase 1 Mus musculus 8-12 17403913-4 2007 Whereas Nat1 and Nat2 can efficiently acetylate many arylamines, few substrates appear to be appreciably metabolized by Nat3. aniline 53-63 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 17-21 17936995-1 2007 The product of gene NAT2 (N-acetyltransferase 2) is involved in the biotransformation system and participates in detoxication of some arylamine derivatives (in particular 2-aminofluorene, 4-aminobiphenyl and 4-naphthylamine) which are strongly mutagenic and carcinogenic. aniline 134-143 N-acetyltransferase 2 Homo sapiens 20-24 17936995-1 2007 The product of gene NAT2 (N-acetyltransferase 2) is involved in the biotransformation system and participates in detoxication of some arylamine derivatives (in particular 2-aminofluorene, 4-aminobiphenyl and 4-naphthylamine) which are strongly mutagenic and carcinogenic. aniline 134-143 N-acetyltransferase 2 Homo sapiens 26-47 17537267-2 2007 Acetylation catalyzed by NAT1 and NAT2 are important in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. aniline 80-90 N-acetyltransferase 1 Homo sapiens 25-29 17537267-2 2007 Acetylation catalyzed by NAT1 and NAT2 are important in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. aniline 80-90 N-acetyltransferase 2 Homo sapiens 34-38 17444628-2 2007 The aromaticity of the ring in variously substituted aniline/anilinium/anilide derivatives in their H-bonded complexes with various Broensted acids and bases was a subject of an analysis based on 332 experimental geometries retrieved from the Cambridge Structural Database and geometries optimized at the B3LYP/6-311+G** and MP2/aug-cc-pVDZ levels of theory. aniline 53-60 tryptase pseudogene 1 Homo sapiens 325-328 17201400-2 2007 An analysis of experimental geometries retrieved from the CSD base and computational modeling of aniline and its derivatives and their H-bonded complexes by use of B3LYP/6-311+G** and MP2/aug-cc-pVDZ showed that the degree of pyramidalization of the amino group depends on H-bonding, which exists in two forms, (i) NH...B (base) and (ii) N...HB (Bronsted acid), both of which affect the shape of the NH2 group. aniline 97-104 tryptase pseudogene 1 Homo sapiens 184-187 17251307-5 2007 Therefore, the three nitrogenous ligands aniline, imidazole, and triazole were used as binding spectra standards with purified human CYP3A4 and CYP2C9, because their small size should not present any steric limitations in their accessing the heme prosthetic group. aniline 41-48 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 133-139 17251307-5 2007 Therefore, the three nitrogenous ligands aniline, imidazole, and triazole were used as binding spectra standards with purified human CYP3A4 and CYP2C9, because their small size should not present any steric limitations in their accessing the heme prosthetic group. aniline 41-48 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 144-150 17188862-2 2007 Variation of the solubilizing amine tail or removal of the methoxy group from either C-6 of the quinoline core or C-5 of the aniline headpiece led to reduced activity. aniline 125-132 complement C5 Homo sapiens 114-117 16769251-7 2006 The metabolism of many exogenous compounds including benzo(a)pyrene (BaP), pyrene, ethoxyresorufin, ethoxycoumarin and aniline is mediated by P450 enzymes in tissues of marine invertebrates. aniline 119-126 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 142-146 17392017-0 2007 Arylamine N-acetyltransferase I. Arylamine N-acetyltransferase I (NAT1) is a phase II enzyme that acetylates a wide range of arylamine and hydrazine substrates. aniline 125-134 N-acetyltransferase 1 Homo sapiens 66-70 17019473-2 2006 While H(2)Py-Ph and H(2)Py-Me show fluorescence around 420 nm from the local excited state of the dihydropyridine chromophore, H(2)Py-PhN(CH(3))(2) exhibits fluorescence around 520 nm from the intramolecular charge transfer (ICT) state involving the aniline and dihydropyridine groups as donor and acceptor, respectively. aniline 250-257 carbamoyl-phosphate synthase 1 Homo sapiens 134-137 16835218-0 2006 Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. aniline 50-59 DNA polymerase eta Homo sapiens 81-99 16857211-1 2006 Arylamine N-acetyltransferases (NAT1 and NAT2) acetylate and detoxify arylamine carcinogens. aniline 70-79 N-acetyltransferase 1 Homo sapiens 32-36 16857211-1 2006 Arylamine N-acetyltransferases (NAT1 and NAT2) acetylate and detoxify arylamine carcinogens. aniline 70-79 N-acetyltransferase 2 Homo sapiens 41-45 16814601-1 2007 Fourier transform infrared spectroscopy has been employed to investigate the detailed chain structure changes during the chemical oxidative polymerisation of aniline in different reaction conditions including different polarity reaction medium, reaction temperature, reactants molar ratio and in the presence of different transition metal ions such as Fe2+, Co2+, Ni2+ and Cu2+. aniline 158-165 complement C2 Homo sapiens 358-361 17080401-1 2006 4-Aminobiphenyl (4-ABP) is an arylamine that has long been associated with human and animal urinary bladder cancer. aniline 30-39 amine oxidase copper containing 1 Homo sapiens 19-22 17080401-7 2006 The kinetic parameters of the isozymes most commonly involved in arylamine glucuronidation, namely UGT1A4 and UGT1A9, were also determined. aniline 65-74 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 99-105 16857729-10 2006 The Nat2 KO model will be useful in future studies to assess the role of Nat2 in arylamine carcinogenesis. aniline 81-90 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 4-8 16829073-0 2006 Arylamine based cathepsin K inhibitors: investigating P3 heterocyclic substituents. aniline 0-9 cathepsin K Homo sapiens 16-27 16959263-2 2006 The determinants of NAT substrate specificity are not known, yet this knowledge is required to understand why NAT enzymes acetylate some arylamines, but not others. aniline 137-147 bromodomain containing 2 Homo sapiens 20-23 16959263-2 2006 The determinants of NAT substrate specificity are not known, yet this knowledge is required to understand why NAT enzymes acetylate some arylamines, but not others. aniline 137-147 bromodomain containing 2 Homo sapiens 110-113 16829624-9 2006 Recombinant rat Nat3 was functional and catalyzed the N-acetylation of several arylamine substrates, including 3-ethylaniline, 3,5-dimethylaniline, 5-aminosalicylic acid, 4-aminobiphenyl, 4,4"-methylenedianiline, 4,4"-methylenebis(2-chloroaniline), and 2-aminofluorene, and the O-acetylation of N-hydroxy-4-aminobiphenyl. aniline 79-88 N-acetyltransferase 3 Rattus norvegicus 16-20 16829624-10 2006 The relative affinities of arylamine carcinogens such as 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and 2-aminofluorene for N- and O-acetylation via recombinant rat Nat3 were comparable with recombinant rat Nat1 and higher than for recombinant rat Nat2. aniline 27-36 N-acetyltransferase 3 Rattus norvegicus 166-170 16829624-10 2006 The relative affinities of arylamine carcinogens such as 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and 2-aminofluorene for N- and O-acetylation via recombinant rat Nat3 were comparable with recombinant rat Nat1 and higher than for recombinant rat Nat2. aniline 27-36 N-acetyltransferase 1 Rattus norvegicus 208-212 16829624-10 2006 The relative affinities of arylamine carcinogens such as 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and 2-aminofluorene for N- and O-acetylation via recombinant rat Nat3 were comparable with recombinant rat Nat1 and higher than for recombinant rat Nat2. aniline 27-36 N-acetyltransferase 2 Rattus norvegicus 249-253 17019473-3 2006 Upon addition of an acid to the solution of H(2)Py-PhN(CH(3))(2), the amino group in the aniline is protonated. aniline 89-96 carbamoyl-phosphate synthase 1 Homo sapiens 51-54 16055332-1 2005 Starting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited tumour growth in a mouse xenograft model. aniline 118-125 erb-b2 receptor tyrosine kinase 2 Mus musculus 174-179 16827944-1 2006 BACKGROUND: N-acetyltransferase 2 (NAT2) metabolizes arylamines and hydrazines moeities found in many therapeutic drugs, chemicals and carcinogens. aniline 53-63 N-acetyltransferase 2 Homo sapiens 12-33 16827944-1 2006 BACKGROUND: N-acetyltransferase 2 (NAT2) metabolizes arylamines and hydrazines moeities found in many therapeutic drugs, chemicals and carcinogens. aniline 53-63 N-acetyltransferase 2 Homo sapiens 35-39 15978860-5 2006 The reduction potentials of CuL2x in DMSO are sensitive to aniline moieties. aniline 59-66 cullin 2 Homo sapiens 28-32 16341845-13 2006 In particular, transcripts of CYP1B1 and CYP4B1 are present, coding for enzymes which are active in the metabolism of polycyclic aromatic hydrocarbons and arylamines, respectively. aniline 155-165 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-36 16341845-13 2006 In particular, transcripts of CYP1B1 and CYP4B1 are present, coding for enzymes which are active in the metabolism of polycyclic aromatic hydrocarbons and arylamines, respectively. aniline 155-165 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 41-47 16169568-0 2006 Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity. aniline 81-88 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 35-39 16169568-4 2006 AP-1 DNA-binding activity in the NEs of freshly isolated splenocytes from aniline-treated rats increased in comparison to the controls, as determined by electrophoretic mobility shift assay (EMSA). aniline 74-81 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-4 16169568-7 2006 Aniline exposure induced increases in the phosphorylation of the three classes of MAPKs: extracellular-signal-regulated kinase (ERK 1/2), c-Jun N-terminal kinase (JNK 1/2), and p38 MAPKs. aniline 0-7 mitogen activated protein kinase 3 Rattus norvegicus 128-135 16169568-7 2006 Aniline exposure induced increases in the phosphorylation of the three classes of MAPKs: extracellular-signal-regulated kinase (ERK 1/2), c-Jun N-terminal kinase (JNK 1/2), and p38 MAPKs. aniline 0-7 mitogen activated protein kinase 14 Rattus norvegicus 177-180 16169568-8 2006 Furthermore, TGF-beta1 mRNA expression showed a 3-fold increase in the spleens of aniline-treated rats. aniline 82-89 transforming growth factor, beta 1 Rattus norvegicus 13-22 16137816-1 2005 CYP1A1 is an extrahepatic enzyme largely involved in the bioactivation of various procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) and arylamines. aniline 149-159 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16314733-1 2005 Arylamine carcinogens and drugs are N-acetylated by cytosolic N-acetyltransferase (NAT), which uses acetyl-coenzyme A as a cofactor. aniline 0-9 bromodomain containing 2 Homo sapiens 62-81 16314733-1 2005 Arylamine carcinogens and drugs are N-acetylated by cytosolic N-acetyltransferase (NAT), which uses acetyl-coenzyme A as a cofactor. aniline 0-9 bromodomain containing 2 Homo sapiens 83-86 16314733-2 2005 NAT plays an initial role in the metabolism of these arylamine compounds. aniline 53-62 bromodomain containing 2 Homo sapiens 0-3 16003747-9 2006 A metaanalysis risk estimate of case-control studies of NAT2 acetylation and bladder cancer in Asian populations without occupational arylamine exposures showed an increased risk for slow acetylators. aniline 134-143 N-acetyltransferase 2 Homo sapiens 56-60 16202803-1 2005 In the present study, a hydrophilic bifunctional polymeric resin (LS-2) with sulfonic groups was synthesized, and the adsorption performance of three aniline compounds, aniline, 4-methylaniline, and 4-nitroaniline onto LS-2 was compared with that on the commercial Amberlite XAD-4. aniline 150-157 serpin family D member 1 Homo sapiens 66-70 16202803-2 2005 The uptake of the aniline compounds on LS-2 is a procedure of coexistence of physisorption and chemisorption and obeys the pseudo-second order rate equation, while the uptake of the compounds on XAD-4 is merely a physical adsorption and follows the pseudo-first order rate equation. aniline 18-25 serpin family D member 1 Homo sapiens 39-43 16202803-4 2005 Dynamic adsorption and desorption studies for aniline on LS-2 show that the breakthrough adsorption capacity and the total adsorption capacity are 0.96 and 1.24 mmol per milliliter resin, respectively. aniline 46-53 serpin family D member 1 Homo sapiens 57-61 16161104-0 2005 Reducing the expression of glutathione transferase D mRNA in Drosophila melanogaster exposed to phenol and aniline. aniline 107-114 Glutathione S transferase O3 Drosophila melanogaster 27-50 16161104-2 2005 The purpose of the present study was to examine the expression of glutathione transferase D mRNA in fruit flies altered by long-term exposure to phenol and aniline. aniline 156-163 Glutathione S transferase O3 Drosophila melanogaster 66-89 16161104-4 2005 The level of each glutathione transferase D mRNA expressed in the phenol-treated and aniline-treated strains of adult fruit flies differed after chemical treatment. aniline 85-92 Glutathione S transferase O3 Drosophila melanogaster 18-41 16161104-5 2005 Aniline was more potent than phenol in suppressing the expression of cytosolic glutathione transferase D mRNA. aniline 0-7 Glutathione S transferase O3 Drosophila melanogaster 79-102 16161104-6 2005 Aniline reduced the level of glutathione transferase mRNA expressed in the aniline-treated strain to less than a 0.5 fraction as compared to that measured in the wild-type strain. aniline 0-7 Glutathione S transferase O3 Drosophila melanogaster 29-52 16161104-6 2005 Aniline reduced the level of glutathione transferase mRNA expressed in the aniline-treated strain to less than a 0.5 fraction as compared to that measured in the wild-type strain. aniline 75-82 Glutathione S transferase O3 Drosophila melanogaster 29-52 18958679-9 2005 Furthermore, analysis of serum cytokines showed significant increases in G-CSF levels in OAA- and aniline-treated mice. aniline 98-105 peripheral blood stem cell response to granulocyte colony stimulating factor 1 Mus musculus 73-78 15927366-1 2005 In this paper a new bifunctional polymeric resin (LS-2) was synthesized by introducing sulfonic groups onto the surface of the resin during the post-crossing of chloromethyl low crosslinking macroporous poly-styrene resin, and the comparison of the adsorption properties of LS-2 with Amberlite XAD-4 toward aniline and 4-methylaniline in aqueous solutions was made. aniline 307-314 serpin family D member 1 Homo sapiens 50-54 15927366-5 2005 The adsorption for aniline or 4-methylaniline on LS-2 was proved to be an endothermic process and increasing temperature was favorable. aniline 19-26 serpin family D member 1 Homo sapiens 49-53 15927366-6 2005 From the studies on the adsorption thermodynamics, static equilibrium adsorption, and the desorption conditions, an important conclusion can be drawn that the adsorption for aniline or 4-methylaniline on the LS-2 is a coexistence process of physical adsorption and chemical transition. aniline 174-181 serpin family D member 1 Homo sapiens 208-212 16083506-1 2005 BACKGROUND: N-acetyltransferase 2 is phase II metabolizing enzyme that participates in the bioconversion of heterocyclic arylamines into electrophilic nitrenium ions, which are important ultimate carcinogens that are directly implicated in tumor initiation process. aniline 121-131 N-acetyltransferase 2 Homo sapiens 12-33 15796204-1 2005 Many arylamine and hydrazine drugs are acetylated by cytosolic N-acetyltransferase (NAT). aniline 5-14 bromodomain containing 2 Homo sapiens 63-82 16128080-1 2005 Kinetic degradation process of PAn films during aniline polymerization was in situ monitored by UV-Visible absorption spectrum. aniline 48-55 adenosine deaminase 2 Homo sapiens 31-34 15997102-4 2005 The effects of halogen-substitution in 32 aniline derivatives on the CYP2E1 inhibition can be summarized as follows: more enhancement by chlorine- and bromine-substitution than by fluorine-substitution, more enhancement by para- and metha-halogen-substitution than by ortho-halogen-substitution, and more enhancement by dihalogen-substitution than by mono- and trihalogen-substitution except for trifluorine-substitution. aniline 42-49 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 69-75 15755159-2 2005 TpRu(PPh3)(CH3CN)2 PF6 (10 mol %) catalyst effected the nucleophilic addition of water, alcohols, aniline, acetylacetone, pyrroles, and dimethyl malonate to unfunctionalized enediynes under suitable conditions (100 degrees C, 12-24 h) and gave functionalized benzene products in good yields. aniline 98-105 sperm associated antigen 17 Homo sapiens 19-22 15796204-1 2005 Many arylamine and hydrazine drugs are acetylated by cytosolic N-acetyltransferase (NAT). aniline 5-14 bromodomain containing 2 Homo sapiens 84-87 15796174-1 2005 It is well documented that N-acetyltransferase (NAT) plays a key role in the N-acetylation of arylamine compounds. aniline 94-103 AT695_RS04655 Staphylococcus aureus 27-46 16003948-5 2005 Arylamine substrate specificities were determined for human rNATI and hamster rNAT2. aniline 0-9 N-acetyltransferase 2 Rattus norvegicus 78-83 15603960-3 2005 Optimization of the aniline portion revealed substitution patterns, which yielded potent antagonist activity against the WT AR as well as the MT AR found in the LNCaP and PCa2b human prostate tumor cell lines. aniline 20-27 prostate cancer associated transcript 2 Homo sapiens 171-175 15915151-2 2005 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. aniline 203-214 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 16128080-3 2005 The experiment results displayed that the more positive the anodic potential, the higher the acidity of the solution, the higher the concentration of aniline, the faster the PAn films degradation speed. aniline 150-157 adenosine deaminase 2 Homo sapiens 174-177 15694462-7 2005 IL-1alpha, IL-6, and TNF-alpha mRNA levels showed 6.9-, 2.9-, and 2.6-fold increases, respectively, in the spleens of aniline-treated rats in comparison to the controls. aniline 118-125 interleukin 1 alpha Rattus norvegicus 0-9 15694462-7 2005 IL-1alpha, IL-6, and TNF-alpha mRNA levels showed 6.9-, 2.9-, and 2.6-fold increases, respectively, in the spleens of aniline-treated rats in comparison to the controls. aniline 118-125 interleukin 6 Rattus norvegicus 11-15 15694462-7 2005 IL-1alpha, IL-6, and TNF-alpha mRNA levels showed 6.9-, 2.9-, and 2.6-fold increases, respectively, in the spleens of aniline-treated rats in comparison to the controls. aniline 118-125 tumor necrosis factor Rattus norvegicus 21-30 15694462-9 2005 NF-kappa B p65 level in the nuclear extracts of cultured splenocytes of aniline-treated rats showed a 2-fold increase in comparison to the controls as quantitated by NF-kappa B p65-specific ELISA. aniline 72-79 synaptotagmin 1 Rattus norvegicus 11-14 15694462-9 2005 NF-kappa B p65 level in the nuclear extracts of cultured splenocytes of aniline-treated rats showed a 2-fold increase in comparison to the controls as quantitated by NF-kappa B p65-specific ELISA. aniline 72-79 synaptotagmin 1 Rattus norvegicus 177-180 15694462-12 2005 The results indicate that aniline exposure causes enhanced expression of IL-1alpha, IL-6, and TNF-alpha, both at mRNA and protein levels, suggesting their role in splenic fibrosis. aniline 26-33 interleukin 1 alpha Rattus norvegicus 73-82 15694462-12 2005 The results indicate that aniline exposure causes enhanced expression of IL-1alpha, IL-6, and TNF-alpha, both at mRNA and protein levels, suggesting their role in splenic fibrosis. aniline 26-33 interleukin 6 Rattus norvegicus 84-88 15694462-12 2005 The results indicate that aniline exposure causes enhanced expression of IL-1alpha, IL-6, and TNF-alpha, both at mRNA and protein levels, suggesting their role in splenic fibrosis. aniline 26-33 tumor necrosis factor Rattus norvegicus 94-103 15603938-5 2005 In contrast to what was predicted by the model, SAR around this new series was dictated by the aniline portion rather than the bicyclic portion of the molecule. aniline 95-102 sarcosine dehydrogenase Homo sapiens 48-51 15816529-2 2005 NAT plays an important role in the metabolizing of those arylamine compounds. aniline 57-66 bromodomain containing 2 Homo sapiens 0-3 15723621-1 2005 Arylamine N-acetyltransferases (NAT) are xenobiotic-metabolizing enzymes responsible for N-acetylation of many arylamines. aniline 111-121 bromodomain containing 2 Homo sapiens 10-30 15723621-1 2005 Arylamine N-acetyltransferases (NAT) are xenobiotic-metabolizing enzymes responsible for N-acetylation of many arylamines. aniline 111-121 bromodomain containing 2 Homo sapiens 32-35 15796174-1 2005 It is well documented that N-acetyltransferase (NAT) plays a key role in the N-acetylation of arylamine compounds. aniline 94-103 AT695_RS04655 Staphylococcus aureus 48-51 15310196-5 2004 The product is an intermediate nitrene (PhN) or a protonated nitrene (PhNH(+)) which is captured by water to give PhNHOH or aniline to give PhNHNHPh. aniline 124-131 carbamoyl-phosphate synthase 1 Homo sapiens 40-43 15521013-1 2004 BACKGROUND AND AIMS: Cytochrome P450 1A1 catalyzes the degradation of endobiotics (estradiol, fatty acids, and so on) and the bioactivation of numerous environmental procarcinogens, such as arylamines and polycyclic aromatic hydrocarbons, that are found in food. aniline 190-200 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-40 15450435-2 2004 To clarify whether the human and rodent bladder carcinogenic arylamines are activated via either NAT1 or NAT2 to cause genotoxicity, a SOS/umu genotoxicity assay was used, with the strains S. typhimurium NM6001 (NAT1-overexpressing strain), S. typhimurium NM6002 (NAT2-overexpressing strain), and S. typhimurium NM6000 (O-AT-deficient parent strain). aniline 61-71 N-acetyltransferase 1 Homo sapiens 97-101 15450435-11 2004 The NAT1-overexpressing strain can be used to determine the genotoxic activation of bladder carcinogenic arylamines in the umu test and could provide a tool for predicting the carcinogenic potential of arylamines. aniline 105-115 N-acetyltransferase 1 Homo sapiens 4-8 15350687-1 2004 In the organism of mammals, important detoxification pathways of arylamines are catalysed by N-acetyltransferase 2 (NAT2). aniline 65-75 N-acetyltransferase 2 Homo sapiens 93-114 15350687-1 2004 In the organism of mammals, important detoxification pathways of arylamines are catalysed by N-acetyltransferase 2 (NAT2). aniline 65-75 N-acetyltransferase 2 Homo sapiens 116-120 15256524-9 2004 The CYP2D6 enzyme activates and inactivates toxins; the NAT2 enzyme bioactivates arylamines to protein-binding metabolites. aniline 81-91 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 4-10 15256524-9 2004 The CYP2D6 enzyme activates and inactivates toxins; the NAT2 enzyme bioactivates arylamines to protein-binding metabolites. aniline 81-91 N-acetyltransferase 2 Homo sapiens 56-60 15279827-5 2004 The amounts of APNH from norharman and aniline were 33 ng for CYP1A1, 15 ng for CYP3A4, 7 ng for CYP2D6, 6 ng for CYP1A2 and 5 ng for CYP2B6. aniline 39-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 15279827-5 2004 The amounts of APNH from norharman and aniline were 33 ng for CYP1A1, 15 ng for CYP3A4, 7 ng for CYP2D6, 6 ng for CYP1A2 and 5 ng for CYP2B6. aniline 39-46 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 80-86 15279827-11 2004 Based on these observations, it is suggested that the practical major contributors to the formation of APNH from norharman and aniline are CYP3A4 and CYP1A2, the responsible reactions mainly occurring in the liver. aniline 127-134 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 139-145 15279827-11 2004 Based on these observations, it is suggested that the practical major contributors to the formation of APNH from norharman and aniline are CYP3A4 and CYP1A2, the responsible reactions mainly occurring in the liver. aniline 127-134 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 150-156 15246087-2 2004 Structural optimization of the aniline moiety of 4-anilinopyrazolopyridine derivative 3a, which is one of the newly discovered chemical leads for PDE4 inhibitors from our in-house library, was performed successfully. aniline 31-38 phosphodiesterase 4A Homo sapiens 146-150 15487710-1 2004 Urine p-aminophenol (PAP) concentration serves as a biological marker for occupational exposures to aniline. aniline 100-107 poly(A) polymerase alpha Homo sapiens 6-19 15142597-4 2004 Secondly, the electrode is hydrolyzed in 6.0 mol/dm(3) hydrochloric acid solution to remove the uricase that may be affected by aniline monomer from PANI film. aniline 128-135 urate oxidase (pseudogene) Homo sapiens 96-103 15487710-1 2004 Urine p-aminophenol (PAP) concentration serves as a biological marker for occupational exposures to aniline. aniline 100-107 poly(A) polymerase alpha Homo sapiens 21-24 15028720-4 2004 Differences in AHR affinity between inbred mouse strains reflect variations in CYP1 inducibility and clearly have been shown to be associated with differences in risk of toxicity or cancer caused by PAHs and arylamines. aniline 208-218 aryl-hydrocarbon receptor Mus musculus 15-18 15028720-4 2004 Differences in AHR affinity between inbred mouse strains reflect variations in CYP1 inducibility and clearly have been shown to be associated with differences in risk of toxicity or cancer caused by PAHs and arylamines. aniline 208-218 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 79-83 15028720-6 2004 Mouse lines having one or another of the Cyp1 genes disrupted have shown paradoxical effects; in the test tube or in cell culture these enzymes show metabolic activation of PAHs or arylamines, whereas in the intact animal these enzymes are sometimes more important in the role of detoxification than metabolic potentiation. aniline 181-191 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 41-45 15142281-3 2004 In addition to its xenobiotic-metabolising capacity, human arylamine N-acetyltransferase type-1 (NAT1) acetylates the folate catabolite para-aminobenzoylglutamate and is implicated in folate metabolism. aniline 59-68 N-acetyltransferase 1 Homo sapiens 97-101 15279101-1 2004 Photocatalytic degradation of aqueous solution of aniline derivatives such as ortho-nitroaniline (ONA), meta-nitroaniline (MNA), para-nitroaniline (PNA), 4-bromoaniline (4-BrA) and 2-chloroaniline (2-ClA) were carried out over ZnO or TiO2 (anatase and rutile) in a photocatalytic reactor. aniline 50-57 selectin P ligand Homo sapiens 200-203 15274316-1 2004 Arylamine N-acetyltransferase (NAT) plays an important role in the metabolism of 2-aminofluorene (AF) and some types of arylamine drugs and carcinogens. aniline 120-129 bromodomain containing 2 Homo sapiens 10-29 15274316-1 2004 Arylamine N-acetyltransferase (NAT) plays an important role in the metabolism of 2-aminofluorene (AF) and some types of arylamine drugs and carcinogens. aniline 120-129 bromodomain containing 2 Homo sapiens 31-34 15274340-1 2004 Many arylamines (including carcinogens) and hydrazine drugs are acetylated by the cytosolic N-acetyltransferase (NAT). aniline 5-15 bromodomain containing 2 Homo sapiens 113-116 15274340-2 2004 NAT plays an important role in the first step of arylamine metabolism and has been found in immortalized human cell lines, human and laboratory animal tissues. aniline 49-58 bromodomain containing 2 Homo sapiens 0-3 15185372-5 2004 The selective inhibition of EGFR by 10 is considered to be due to the substitution of the dihydroxy groups on the benzyl moiety for a boronic acid group at the para position, whereas the selective inhibition of Flt-1 by 12 is due to the substitution of the carboxyl group on the aniline moiety in the lavendustin pharmacophore 1 for a boronic acid group. aniline 279-286 fms related receptor tyrosine kinase 1 Homo sapiens 211-216 15320760-1 2004 Human arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) are polymorphic phase II xenobiotic-metabolising enzymes (XME) that acetylate arylamine compounds. aniline 6-15 N-acetyltransferase 1 Homo sapiens 46-50 14648207-2 2004 In the human liver, arylamines are N-hydroxylated by a cytochrome P450 (CYP)1A2-catalyzed reaction, which produces a substrate for O-esterification that can be catalyzed by N-acetyltransferases (NAT) or sulfotransferases (SULT). aniline 20-30 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 55-79 15013210-6 2004 Cytochrome P450 2E1-dependent aniline and p-nitrophenol hydroxylases activities in microsomal incubations were significantly inhibited by Moutan Cortex. aniline 30-37 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 0-19 15225898-2 2004 NAT2 genotype might modify the role of cigarette smoking, a source of arylamine exposure, in breast cancer. aniline 70-79 N-acetyltransferase 2 Homo sapiens 0-4 15025513-6 2004 ECHA reacted with aniline to give ethyl (hydroxamino)(phenylimino)acetate [PhN=C(NHOH)CO2Et]. aniline 18-25 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Homo sapiens 0-4 15025513-7 2004 This product was different from ethyl [(phenylamino)carbonyl]carbamate [PhNHC(=O)NHCO2Et], which was synthesized by reacting ethyl isocyanatoformate (OCN.CO2Et) with aniline. aniline 166-173 bone gamma-carboxyglutamate protein Homo sapiens 150-153 14744142-1 2004 Cytochrome P450 (P450) 1A2 is the major enzyme involved in the metabolism of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline (MeIQ) and other heterocyclic arylamines and their bioactivation to mutagens. aniline 151-161 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-26 15320760-1 2004 Human arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) are polymorphic phase II xenobiotic-metabolising enzymes (XME) that acetylate arylamine compounds. aniline 6-15 N-acetyltransferase 2 Homo sapiens 55-59 15750580-2 2004 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. aniline 203-214 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 17564315-1 2004 N-acetylation plays an important role in the metabolism of arylamine drugs and carcinogens and is catalyzed by cytosolic N-acetyltransferase (NAT). aniline 59-68 bromodomain containing 2 Homo sapiens 121-140 14618622-1 2004 Cigarette smoke contains polycyclic hydrocarbons and arylamines that may both be activated by sulfotransferase, encoded by SULT1A1. aniline 53-63 sulfotransferase family 1A member 1 Homo sapiens 123-130 14705222-4 2004 We saw some evidence of interaction between NAT genotypes and use of hair dyes (a source of arylamines), with higher risk seen among hair dye users who had both the *10 NAT1 allele and the NAT2 slow-acetylation genotype (OR 2.9, 95% CI 1.2, 6.9 in this subgroup compared with all others). aniline 92-102 bromodomain containing 2 Homo sapiens 44-47 14705222-4 2004 We saw some evidence of interaction between NAT genotypes and use of hair dyes (a source of arylamines), with higher risk seen among hair dye users who had both the *10 NAT1 allele and the NAT2 slow-acetylation genotype (OR 2.9, 95% CI 1.2, 6.9 in this subgroup compared with all others). aniline 92-102 N-acetyltransferase 1 Homo sapiens 169-173 14705222-4 2004 We saw some evidence of interaction between NAT genotypes and use of hair dyes (a source of arylamines), with higher risk seen among hair dye users who had both the *10 NAT1 allele and the NAT2 slow-acetylation genotype (OR 2.9, 95% CI 1.2, 6.9 in this subgroup compared with all others). aniline 92-102 N-acetyltransferase 2 Homo sapiens 189-193 17564315-1 2004 N-acetylation plays an important role in the metabolism of arylamine drugs and carcinogens and is catalyzed by cytosolic N-acetyltransferase (NAT). aniline 59-68 bromodomain containing 2 Homo sapiens 142-145 14636699-11 2003 Immunohistochemical analysis of inducible nitric oxide synthase (iNOS) also showed increased expression in the red pulp of the spleens from aniline-treated rats; the cellular localization was similar to nitrated proteins. aniline 140-147 nitric oxide synthase 2 Rattus norvegicus 32-63 14636699-11 2003 Immunohistochemical analysis of inducible nitric oxide synthase (iNOS) also showed increased expression in the red pulp of the spleens from aniline-treated rats; the cellular localization was similar to nitrated proteins. aniline 140-147 nitric oxide synthase 2 Rattus norvegicus 65-69 14592665-4 2003 We previously reported that MIC-1 expression is rapidly induced after a wide variety of murine acute and chronic liver injuries including aniline dye administration. aniline 138-145 growth differentiation factor 15 Mus musculus 28-33 14624563-2 2003 Incorporation of soft thioether donors into an aniline-derived ligand framework that can be linked to a fluorescein platform affords sensor MS1, which shows a approximately 5-fold increase in integrated emission upon addition of 1 equiv of Hg(II). aniline 47-54 MS Homo sapiens 140-143 12754290-1 2003 The human arylamine N-acetyltransferases (NATs) NAT1 and NAT2 are enzymes responsible for the acetylation of many arylamines and hydrazines, thereby playing an important role in both detoxification and activation of many drugs and carcinogens. aniline 114-124 N-acetyltransferase 1 Homo sapiens 48-52 14592520-1 2003 To improve the pharmacokinetics of a previously reported series of dipeptidyl nitrile cathepsin B inhibitors, the P(2)-P(3) amide group was replaced with an arylamine. aniline 157-166 cathepsin B Homo sapiens 86-97 12941327-3 2003 Secondary cellular assays revealed that a compound possessing the appropriate aniline substituents inhibited MEK1 as well as MAPK phosphorylation, thereby acting as a dual inhibitor of the Ras-MAPK signaling cascade. aniline 78-85 mitogen-activated protein kinase kinase 1 Homo sapiens 109-113 12754290-1 2003 The human arylamine N-acetyltransferases (NATs) NAT1 and NAT2 are enzymes responsible for the acetylation of many arylamines and hydrazines, thereby playing an important role in both detoxification and activation of many drugs and carcinogens. aniline 114-124 N-acetyltransferase 2 Homo sapiens 57-61 12700401-8 2003 Protein expression of CYP1A2, another enzyme involved in the biotransformation of arylamines, showed a similar pattern. aniline 82-92 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 22-28 12781211-0 2003 Curcumin inhibited the arylamines N-acetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells (A549). aniline 23-33 bromodomain containing 2 Homo sapiens 34-53 12781211-1 2003 It is well known that N-acetyltransferase (NAT) plays an important role in the arylamine metabolism. aniline 79-88 bromodomain containing 2 Homo sapiens 22-41 12781211-1 2003 It is well known that N-acetyltransferase (NAT) plays an important role in the arylamine metabolism. aniline 79-88 bromodomain containing 2 Homo sapiens 43-46 12618593-2 2003 N-acetylation and O-acetylation, catalysed by N-acetyltransferase 1 (NAT1) and 2 (NAT2), activate and/or deactivate arylamines to electrophilic intermediates that bind DNA and initiate tumours in target organs. aniline 116-126 N-acetyltransferase 1 Homo sapiens 46-67 12618593-2 2003 N-acetylation and O-acetylation, catalysed by N-acetyltransferase 1 (NAT1) and 2 (NAT2), activate and/or deactivate arylamines to electrophilic intermediates that bind DNA and initiate tumours in target organs. aniline 116-126 N-acetyltransferase 1 Homo sapiens 69-73 12618593-2 2003 N-acetylation and O-acetylation, catalysed by N-acetyltransferase 1 (NAT1) and 2 (NAT2), activate and/or deactivate arylamines to electrophilic intermediates that bind DNA and initiate tumours in target organs. aniline 116-126 N-acetyltransferase 2 Homo sapiens 82-86 12628581-0 2003 Up-regulation of transforming growth factor-beta 1 in the spleen of aniline-treated rats. aniline 68-75 transforming growth factor, beta 1 Rattus norvegicus 17-50 12628581-4 2003 Earlier studies have shown that aniline exposure in rats leads to excessive deposition of iron and increased lipid peroxidation in the spleen, which may produce changes in the expression of fibrogenic cytokines, such as transforming growth factor-beta 1 (TGF-beta 1), leading to splenic fibrosis. aniline 32-39 transforming growth factor, beta 1 Rattus norvegicus 220-253 12628581-4 2003 Earlier studies have shown that aniline exposure in rats leads to excessive deposition of iron and increased lipid peroxidation in the spleen, which may produce changes in the expression of fibrogenic cytokines, such as transforming growth factor-beta 1 (TGF-beta 1), leading to splenic fibrosis. aniline 32-39 transforming growth factor, beta 1 Rattus norvegicus 255-265 12628581-5 2003 Therefore, this study was designed to establish whether aniline exposure leads to induction/overexpression of TGF-beta 1 and association of such induction with lipid peroxidation (oxidative stress) in the spleen. aniline 56-63 transforming growth factor, beta 1 Rattus norvegicus 110-120 12628581-9 2003 TGF-beta 1, measured in the supernatants of cultured splenocytes by an ELISA specific for TGF-beta 1, showed a significant increase (60%) in the total TGF-beta 1 from aniline-treated rats. aniline 167-174 transforming growth factor, beta 1 Rattus norvegicus 0-10 12628581-9 2003 TGF-beta 1, measured in the supernatants of cultured splenocytes by an ELISA specific for TGF-beta 1, showed a significant increase (60%) in the total TGF-beta 1 from aniline-treated rats. aniline 167-174 transforming growth factor, beta 1 Rattus norvegicus 90-100 12628581-9 2003 TGF-beta 1, measured in the supernatants of cultured splenocytes by an ELISA specific for TGF-beta 1, showed a significant increase (60%) in the total TGF-beta 1 from aniline-treated rats. aniline 167-174 transforming growth factor, beta 1 Rattus norvegicus 90-100 12628581-10 2003 These increases were further confirmed by Western blot analysis, which showed approximately 2.5-fold increase in cell-associated TGF-beta 1 protein expression in aniline-treated rats. aniline 162-169 transforming growth factor, beta 1 Rattus norvegicus 129-139 12618593-7 2003 NAT1 and NAT2 in liver and prostate catalysed -acetylation of the arylamines above and O-acetylation of N-hydroxy derivatives of 2-aminofluorene, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. aniline 66-76 N-acetyltransferase 1 Homo sapiens 0-4 12618593-7 2003 NAT1 and NAT2 in liver and prostate catalysed -acetylation of the arylamines above and O-acetylation of N-hydroxy derivatives of 2-aminofluorene, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. aniline 66-76 N-acetyltransferase 2 Homo sapiens 9-13 12565961-3 2003 Substitution of chlorine or bromine for fluorine on the aniline ring led to the discovery of subnanomolar factor Xa inhibitors. aniline 56-63 coagulation factor X Homo sapiens 106-115 12680237-1 2003 Arylamine N-acetyltransferase (NAT) plays an important role in the first step of arylamines metabolism. aniline 81-91 bromodomain containing 2 Homo sapiens 10-29 12680237-1 2003 Arylamine N-acetyltransferase (NAT) plays an important role in the first step of arylamines metabolism. aniline 81-91 bromodomain containing 2 Homo sapiens 31-34 12565972-2 2003 We demonstrated that the naphthyl moiety in the aniline-based compounds 1 and 2 can be replaced with benzene-fused heterobicycles and biaryls to give factor Xa inhibitors with improved trypsin selectivity. aniline 48-55 coagulation factor X Homo sapiens 150-159 12628581-11 2003 Furthermore, determination of TGF-beta 1 mRNA expression showed a 4-fold increase in the spleens of aniline-treated rats. aniline 100-107 transforming growth factor, beta 1 Rattus norvegicus 30-40 12628581-12 2003 These results suggest an association between formation of MDA-protein adducts and overexpression of TGF-beta 1 as a result of aniline insult, which together could promote splenic injury and fibrogenesis. aniline 126-133 transforming growth factor, beta 1 Rattus norvegicus 100-110 12715953-3 2003 Acetylation polymorphism relates to the metabolism of a number of arylamine and hydrazine drugs and carcinogens by cytosolic N-acetyltransferase--NAT2. aniline 66-75 N-acetyltransferase 2 Homo sapiens 146-150 12552997-1 2002 N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. aniline 179-189 N-acetyltransferase 2 Homo sapiens 0-21 12552997-1 2002 N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. aniline 179-189 glutathione S-transferase mu 1 Homo sapiens 34-69 12552997-1 2002 N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. aniline 179-189 glutathione S-transferase mu 1 Homo sapiens 71-76 12552997-1 2002 N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. aniline 179-189 glutathione S-transferase theta 1 Homo sapiens 81-86 12376500-2 2002 Cigarette smoke is a rich source of arylamines, which are detoxified by the NAT2 enzyme and activated by the NAT1 enzyme to highly reactive species that can form bulky adducts on DNA. aniline 36-46 N-acetyltransferase 2 Homo sapiens 76-80 12376500-2 2002 Cigarette smoke is a rich source of arylamines, which are detoxified by the NAT2 enzyme and activated by the NAT1 enzyme to highly reactive species that can form bulky adducts on DNA. aniline 36-46 N-acetyltransferase 1 Homo sapiens 109-113 12351147-0 2002 Metabolic oxidation of carcinogenic arylamines by p450 monooxygenases: theoretical support for the one-electron transfer mechanism. aniline 36-46 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 50-54 11829470-1 2002 The human arylamine N-acetyltransferase NAT2 is responsible for the biotransformation of numerous arylamine drugs and carcinogens. aniline 10-19 N-acetyltransferase 2 Homo sapiens 40-44 12057649-5 2002 Optimization of the side chain at the central aniline nitrogen of 7-amidino-2-naphthoanilide has led to several potent and orally active FXa inhibitors. aniline 46-53 coagulation factor X Homo sapiens 137-140 12222688-7 2002 The enzymatic activities for N-acetylation of two arylamine carcinogens (2-aminofluorene, 4-aminobiphenyl), and a sulfonamide drug (sulfamethazine) were over 100-fold lower for NAT2 19 compared to reference NAT2 4. aniline 50-59 N-acetyltransferase 2 Homo sapiens 177-181 12222688-7 2002 The enzymatic activities for N-acetylation of two arylamine carcinogens (2-aminofluorene, 4-aminobiphenyl), and a sulfonamide drug (sulfamethazine) were over 100-fold lower for NAT2 19 compared to reference NAT2 4. aniline 50-59 N-acetyltransferase 2 Homo sapiens 207-211 11799105-7 2002 Full-length NAT hydrolyses Ac-CoA but only in the presence of an arylamine substrate. aniline 65-74 bromodomain containing 2 Homo sapiens 12-15 12214666-13 2002 The CYP1A2-induced hepatocytes isolated from 3-methylcholanthrene administered rats were much more susceptible to some arylamines and were protected by CYP1A2 inhibitors. aniline 119-129 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 4-10 12214666-15 2002 This suggests that in intact hepatocytes CYP1A2 may also catalyze a one-electron oxidation of some arylamines to form prooxidant cation radicals, which cooxidize GSH to form the reactive oxygen species. aniline 99-109 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 41-47 12057865-1 2002 Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl and the arylamines. aniline 244-254 myeloperoxidase Homo sapiens 0-15 12057865-1 2002 Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl and the arylamines. aniline 244-254 myeloperoxidase Homo sapiens 17-20 18968623-4 2002 The results provide a linear detection range of 2-40 muM for aniline with a corresponding limit of detection of 1.4 muM. aniline 61-68 latexin Homo sapiens 53-56 18968623-4 2002 The results provide a linear detection range of 2-40 muM for aniline with a corresponding limit of detection of 1.4 muM. aniline 61-68 latexin Homo sapiens 116-119 18968623-5 2002 The efficacy of the approach has been shown by a 99.5% (RSD=5.5%, N=5) recovery of 2.47 muM spiked aniline in river water. aniline 99-106 latexin Homo sapiens 88-91 18968629-2 2002 The sensing film was prepared by electropolymerization of aniline into polyacrylonitrile (PAN)-coated platinum electrode in the presence of PPO. aniline 58-65 protoporphyrinogen oxidase Homo sapiens 140-143 12030840-10 2002 Because liver CYP1A2 levels are known to vary more than 60-fold between humans, our findings may be relevant to patients who are exposed to arylamines in the workplace. aniline 140-150 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 14-20 12148275-0 2002 Cholesterol esterase and cholesterol oxidase immobilized onto arylamine glass beads. aniline 62-71 carboxyl ester lipase Bos taurus 0-20 12088197-5 2002 These results show an important effect of the NAT1 genetic polymorphism on the N- and O-acetylation of arylamine carcinogens, suggesting modification of cancer susceptibility following exposures to arylamine carcinogens. aniline 103-112 N-acetyltransferase 1 Homo sapiens 46-50 12088197-5 2002 These results show an important effect of the NAT1 genetic polymorphism on the N- and O-acetylation of arylamine carcinogens, suggesting modification of cancer susceptibility following exposures to arylamine carcinogens. aniline 198-207 N-acetyltransferase 1 Homo sapiens 46-50 15618652-9 2002 The activities of lauric acid 12-hydroxylation (a marker for Cyp4a) and aniline p-hydroxylation (a marker for Cyp2e1) in liver microsomes were increased 1.4- to 1.9-fold in female jvs/jvs-type mice. aniline 72-79 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 110-116 11735543-2 2001 The reaction proceeds in DMF/water in the presence of potassium carbonate and catalytic palladium(II) acetate and is compatible with both electron-donating and -withdrawing substituents in the para position of the aniline, and with an alkyl substituent at C-2 of the dienyl sulfone. aniline 214-221 complement C2 Homo sapiens 256-259 12148275-1 2002 Cholesterol esterase (CEase) from bovine pancreas and cholesterol oxidase (COD) from Bravibacterium recombinant type have been immobilized individually and co-immobilized onto arylamine glass (pore diameter 55 nm) through the process of diazotization. aniline 176-185 carboxyl ester lipase Bos taurus 0-20 12148275-2 2002 CEase and COD retained 92.65% and 85.54% of the initial activity with conjugation yields of 7.2 mg/g and 8.3 mg/g support respectively when immobilized individually on arylamine glass beads, but retained 89.58% of the initial activity with a conjugation yield of 2.9 mg/g support when co-immobilized on the same support. aniline 168-177 carboxyl ester lipase Bos taurus 0-5 11764764-5 2001 Kinetic constants for arylamine NAT activities were determined for each of these acetylator groups. aniline 22-31 bromodomain containing 2 Homo sapiens 32-35 11764764-8 2001 This is the first demonstration of acetyl CoA-arylamine NAT activity in human benign prostatic hyperplasia tissues. aniline 46-55 bromodomain containing 2 Homo sapiens 56-59 11681569-5 2001 The aniline and 2-chloroaniline were well separated in an acceptable time on a reversed-phase C18 column eluted with 40% aqueous methanol solution at pH 7.0 and 1.0 ml/min flow-rate. aniline 4-11 Bardet-Biedl syndrome 9 Homo sapiens 94-97 11396144-0 2001 Effects of the butylated hydroxyanisole and butylated hydroxytoluene on the DNA adduct formation and arylamines N-acetyltransferase activity in human colon tumor cells. aniline 101-111 bromodomain containing 2 Homo sapiens 112-131 11428926-3 2001 The search for a suitable back-up candidate centered on the replacement of the aniline moiety at C-6 with an appropriately substituted heterocyle. aniline 79-86 complement C6 Homo sapiens 97-100 14564055-2 2001 Arylamines are metabolised by NAT1 and NAT2 polymorphic enzymes in reactions of carcinogen activation and detoxification. aniline 0-10 N-acetyltransferase 1 Homo sapiens 30-34 11207033-2 2001 The goals of the present study were (i) to assay for the presence of the arylamine acetyltransferases NAT1 and NAT2, and of the cytochrome P450 isoform CYP1A2, in human bladder epithelium; and (ii) to determine whether the activities of these arylamine biotransforming enzymes differ between bladder cancer patients and control subjects. aniline 73-82 N-acetyltransferase 1 Homo sapiens 102-106 11207033-2 2001 The goals of the present study were (i) to assay for the presence of the arylamine acetyltransferases NAT1 and NAT2, and of the cytochrome P450 isoform CYP1A2, in human bladder epithelium; and (ii) to determine whether the activities of these arylamine biotransforming enzymes differ between bladder cancer patients and control subjects. aniline 73-82 N-acetyltransferase 2 Homo sapiens 111-115 11207033-9 2001 Our results suggest that although expression of particular arylamine biotransforming enzymes within the bladder tissue could play a significant role in locally bioactivating arylamine procarcinogens in theory, interindividual variations in CYP1A2, NAT1 and NAT2 activities do not significantly differ between bladder cancer patients and control subjects when potential arylamine exposures are controlled for aniline 59-68 N-acetyltransferase 1 Homo sapiens 248-252 11207033-9 2001 Our results suggest that although expression of particular arylamine biotransforming enzymes within the bladder tissue could play a significant role in locally bioactivating arylamine procarcinogens in theory, interindividual variations in CYP1A2, NAT1 and NAT2 activities do not significantly differ between bladder cancer patients and control subjects when potential arylamine exposures are controlled for aniline 59-68 N-acetyltransferase 2 Homo sapiens 257-261 14564055-2 2001 Arylamines are metabolised by NAT1 and NAT2 polymorphic enzymes in reactions of carcinogen activation and detoxification. aniline 0-10 N-acetyltransferase 2 Homo sapiens 39-43 12889515-1 2001 Genetic regulation of acetyl coenzyme A-dependent N-acetyltransferase (NAT)and O-acetyltransferase (OAT) activities may play an important role in the metabolic activation of arylamine chemicals and carcinogens. aniline 174-183 bromodomain containing 2 Homo sapiens 71-74 11108798-1 2000 Human N-acetyltransferase 1 (NAT1) is a widely distributed enzyme that catalyses the acetylation of arylamine and hydrazine drugs as well as several known carcinogens, and so its levels in the body may have toxicological importance with regard to drug toxicity and cancer risk. aniline 100-109 N-acetyltransferase 1 Homo sapiens 6-27 11108798-1 2000 Human N-acetyltransferase 1 (NAT1) is a widely distributed enzyme that catalyses the acetylation of arylamine and hydrazine drugs as well as several known carcinogens, and so its levels in the body may have toxicological importance with regard to drug toxicity and cancer risk. aniline 100-109 N-acetyltransferase 1 Homo sapiens 29-33 12889515-1 2001 Genetic regulation of acetyl coenzyme A-dependent N-acetyltransferase (NAT)and O-acetyltransferase (OAT) activities may play an important role in the metabolic activation of arylamine chemicals and carcinogens. aniline 174-183 CAS1 domain containing 1 Homo sapiens 79-98 11038234-0 2000 Effects of butylated hydroxyanisole and butylated hydroxytoluene on DNA adduct formation and arylamines N-acetyltransferase activity in PC-3 cells (human prostate tumor) in vitro. aniline 93-103 bromodomain containing 2 Homo sapiens 104-123 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. aniline 222-232 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. aniline 222-232 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 42-48 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. aniline 222-232 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-59 10971207-3 2000 The NAT1 gene locus encodes a structurally related enzyme, NAT1, with catalytic specificity for arylamine acceptor substrates distinct from that exhibited by NAT2. aniline 96-105 N-acetyltransferase 1 Homo sapiens 4-8 10971207-3 2000 The NAT1 gene locus encodes a structurally related enzyme, NAT1, with catalytic specificity for arylamine acceptor substrates distinct from that exhibited by NAT2. aniline 96-105 N-acetyltransferase 1 Homo sapiens 59-63 10917561-1 2000 Genetic polymorphism of the carcinogen metabolizing enzyme N-acetyl transferase 2 (NAT2) may influence susceptibility to bladder cancers related to smoking or to occupational exposure to arylamine carcinogens. aniline 187-196 N-acetyltransferase 2 Homo sapiens 59-81 10917561-1 2000 Genetic polymorphism of the carcinogen metabolizing enzyme N-acetyl transferase 2 (NAT2) may influence susceptibility to bladder cancers related to smoking or to occupational exposure to arylamine carcinogens. aniline 187-196 N-acetyltransferase 2 Homo sapiens 83-87 10946248-1 2000 The mutational spectra generated in AS52 cells at the gpt gene locus by aniline mustards were studied by the isolation of resistant clones and sequencing of the altered gene. aniline 72-79 alanine aminotransferase 1 Cricetulus griseus 54-57 11048673-8 2000 Mullet CYP1A1 did not catalyze monooxygenations of other substrates such as aniline, ethylmorphine, N-nitrosodimethylamine and p-nitrophenol. aniline 76-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 7-13 10737747-2 2000 The design of these compounds was based on coupling of various indole derivatives, previously shown to inhibit 5-HT reuptake, to three different aniline moieties, which are part of known 5-HT(1B/1D) ligands. aniline 145-152 5-hydroxytryptamine receptor 1B Rattus norvegicus 187-194 10794727-1 2000 The human arylamine N-acetyltransferases NAT1 and NAT2 catalyse the acetyl-CoA-dependent N- and O-acetylation of primary arylamine and hydrazine xenobiotics and their N-hydroxylated metabolites. aniline 10-19 N-acetyltransferase 1 Homo sapiens 41-45 10794727-1 2000 The human arylamine N-acetyltransferases NAT1 and NAT2 catalyse the acetyl-CoA-dependent N- and O-acetylation of primary arylamine and hydrazine xenobiotics and their N-hydroxylated metabolites. aniline 10-19 N-acetyltransferase 2 Homo sapiens 50-54 10920545-1 2000 Arylamine N-acetylation capacity by the N-acetyltransferase (NAT) may be an important causative factor in the initiation of cancer. aniline 0-9 N-acetyltransferase 1 Rattus norvegicus 40-59 10920545-1 2000 Arylamine N-acetylation capacity by the N-acetyltransferase (NAT) may be an important causative factor in the initiation of cancer. aniline 0-9 N-acetyltransferase 1 Rattus norvegicus 61-64 10819168-0 2000 The use of "electronic nose" sensor responses to predict the inhibition activity of alcohols on the cytochrome P-450 catalyzed p-hydroxylation of aniline. aniline 146-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 100-116 10819168-1 2000 A quantitative structure activity relationship (QSAR) has been formulated to describe the inhibitory action of a series of alcohols on the cytochrome P-450 catalyzed p-hydroxylation of aniline. aniline 185-192 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 139-155 10737747-4 2000 Conformational restriction of the aniline moiety in 5 only slightly enhanced the 5-HT(1B) affinity, whereas introduction of an aniline moiety with higher conformational flexibility resulted in a less potent 5-HT(1B) receptor ligand as compared to 5. aniline 127-134 5-hydroxytryptamine receptor 1B Rattus norvegicus 207-214 10692486-12 2000 We conclude that NAT1 can be down-regulated by arylamines that are themselves NAT1 substrates. aniline 47-57 N-acetyltransferase 1 Homo sapiens 17-21 10692486-12 2000 We conclude that NAT1 can be down-regulated by arylamines that are themselves NAT1 substrates. aniline 47-57 N-acetyltransferase 1 Homo sapiens 78-82 10469638-6 1999 As NAT2 activity is known to modify risk of arylamine-induced carcinogenesis, our results suggest that exposure to arylamines in the environment may play a role in risk of lung cancer among non-smokers. aniline 44-53 N-acetyltransferase 2 Homo sapiens 3-7 10711628-4 2000 About a two-fold increase in CYP2E-dependent hepatic aniline hydroxylation and a 90-100% increase in CYP1A-dependent ethoxycoumarin-O-deethylase activities in kidney and brain were also observed. aniline 53-60 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 29-34 10634131-10 1999 Therefore, our results suggest that CYP2D6 is involved in the in-vivo aliphatic amine deethylation and N-oxidation of procainamide at its arylamine function in man. aniline 138-147 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 36-42 10568706-6 1999 Aniline hydroxylation activity, an indicator of CYP2E1 catalytic activity, determined on day 4 was 33.8% of untreated control in vehicle + CCl4 treatments while the retinol + CCl4 treatment group was 94.2% of untreated control. aniline 0-7 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 48-54 10568706-6 1999 Aniline hydroxylation activity, an indicator of CYP2E1 catalytic activity, determined on day 4 was 33.8% of untreated control in vehicle + CCl4 treatments while the retinol + CCl4 treatment group was 94.2% of untreated control. aniline 0-7 chemokine (C-C motif) ligand 4 Mus musculus 139-143 10503913-9 1999 The data indicate that the Hprt lymphocyte mutagenesis assay detects arylamine carcinogens, but with relatively low sensitivity. aniline 69-78 hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus 27-31 10746928-7 2000 The observed heterogeneity of NAT1 and NAT2 mRNA expression between human tissue types may be of significance in assessing their contribution to known organ-specific toxicities of various arylamine drugs and carcinogens. aniline 188-197 N-acetyltransferase 1 Homo sapiens 30-34 10746928-7 2000 The observed heterogeneity of NAT1 and NAT2 mRNA expression between human tissue types may be of significance in assessing their contribution to known organ-specific toxicities of various arylamine drugs and carcinogens. aniline 188-197 N-acetyltransferase 2 Homo sapiens 39-43 10885506-2 2000 Using high performance liquid chromatography, the NAT activity for acetylation of arylamine substrates (2-aminofluorene and p-aminobenzoic acid) was determined. aniline 82-91 bromodomain containing 2 Homo sapiens 50-53 21432481-1 2000 Because of the important role ofN-acetyltransferase (NAT) enzymes in both metabolic activation and detoxification of certain precarcinogens, such as homo-and heterocyclic arylamines, extensive research in the past has focused on the relationship between the distribution of different variants of these enzymes and cancer susceptibility. aniline 171-181 bromodomain containing 2 Homo sapiens 53-56 10639280-3 1999 Substitution of the aniline was investigated and clearly indicated that small lipophilic substituents such as halogens or methyl were preferred at the C-4" position. aniline 20-27 complement C4A (Rodgers blood group) Homo sapiens 151-154 10639280-5 1999 Introduction of a hydroxyl group at the meta position of the aniline produced the most potent inhibitors of Flt and KDR tyrosine kinases activity with IC(50) values in the nanomolar range (e.g. 10, 12, 13, 16, and 18). aniline 61-68 fms related receptor tyrosine kinase 1 Homo sapiens 108-111 10639280-5 1999 Introduction of a hydroxyl group at the meta position of the aniline produced the most potent inhibitors of Flt and KDR tyrosine kinases activity with IC(50) values in the nanomolar range (e.g. 10, 12, 13, 16, and 18). aniline 61-68 kinase insert domain receptor Homo sapiens 116-119 10479298-4 1999 By optimizing the aniline substitution pattern, as well as the alkoxy group on the 2-aryl substituent, it is possible to prepare antagonists with subnanomolar affinity for ET(B) and with selectivities in excess of 4000-fold. aniline 18-25 endothelin receptor type B Homo sapiens 172-177 10469638-6 1999 As NAT2 activity is known to modify risk of arylamine-induced carcinogenesis, our results suggest that exposure to arylamines in the environment may play a role in risk of lung cancer among non-smokers. aniline 115-125 N-acetyltransferase 2 Homo sapiens 3-7 10421611-8 1999 CYP2E1 inhibitors diethyldithiocarbamate and aniline also reduced POD activity. aniline 45-52 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 10510890-1 1999 BACKGROUND: N-acetyltransferase (NAT) is known to metabolize the carcinogen arylamine. aniline 76-85 bromodomain containing 2 Homo sapiens 12-31 10510890-1 1999 BACKGROUND: N-acetyltransferase (NAT) is known to metabolize the carcinogen arylamine. aniline 76-85 bromodomain containing 2 Homo sapiens 33-36 10445403-4 1999 Urethane increased EROD (CYP 1A) activity by 40 % (p < 0.01), and hydroxylation of aniline (CYP 2E1) by 14 % in the early phase of anaesthesia and by 60 % (p < 0.01) in the later one. aniline 86-93 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 95-102 10453939-10 1999 Likewise, the activities of cytochrome P450 2B1 (pentoxyresorufin O-depentylation), 2E1 (aniline p-hydroxylation) and 3A2 (testosterone 6beta-hydroxylation) isozymes and the 3A2 mRNA levels in liver were decreased by deoxycholic acid. aniline 89-96 cytochrome P450 2B1 Rattus norvegicus 28-47 10361374-1 1999 Polymorphic arylamine N-acetyltransferase (NAT2) is a detoxification enzyme in the liver. aniline 12-21 N-acetyltransferase 2 Rattus norvegicus 43-47 10392568-1 1999 Commercially available uricase and peroxidase have been immobilized onto alkylamine glass and arylamine glass beads respectively. aniline 94-103 urate oxidase (pseudogene) Homo sapiens 23-30 10217346-2 1999 Exposure to aniline is toxic because it produces methemoglobin. aniline 12-19 hemoglobin subunit gamma 2 Homo sapiens 49-62 10217346-3 1999 Aniline levels are usually not measured in serum; in humans, blood methemoglobin levels are often measured as an index of exposure to aniline. aniline 134-141 hemoglobin subunit gamma 2 Homo sapiens 67-80 10217346-15 1999 The methemoglobin percentage and aniline concentrations in blood increased with increasing aniline doses. aniline 91-98 hemoglobin subunit gamma 2 Homo sapiens 4-17 9820175-5 1998 Specific substrates of CYP included testosterone (catalysed by CYP3A4), paclitaxel (CYP2C8), 7-ethoxyresorufin (CYP1A1, CYP1A2), coumarin (CYP2A6), aniline (CYP2E1) and (+/-)-bufuralol (CYP2D6). aniline 148-155 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 23-26 10207612-1 1999 In human liver microsomes the oxidations of benzene, chlorzoxazone, aniline, dimethylformamide, and 4-nitrophenol were significantly correlated with each other and with the level of cytochrome P450 (CYP) 2E1 estimated by immunoblotting. aniline 68-75 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 182-207 10208636-1 1999 Polymorphisms of N-acetyltransferase type 2 (NAT2) conferring the slow acetylator phenotype have been linked to increased susceptibility to arylamine-induced bladder cancer in Caucasians. aniline 140-149 N-acetyltransferase 2 Homo sapiens 17-43 10208636-1 1999 Polymorphisms of N-acetyltransferase type 2 (NAT2) conferring the slow acetylator phenotype have been linked to increased susceptibility to arylamine-induced bladder cancer in Caucasians. aniline 140-149 N-acetyltransferase 2 Homo sapiens 45-49 10096431-1 1999 In the present study we investigated c-fos expression in rat livers, that was initiated with the three arylamines, 2-acetylaminofluorene, 2-acetylaminophenanthrene and trans-4-acetylaminostilbene. aniline 103-113 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 37-42 10096431-3 1999 Gene expression, determined by the mRNA level, and FOS protein were increased after 52 weeks of treatment in arylamine initiated as well as in phenobarbital only treated animals. aniline 109-118 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 51-54 10701096-0 1999 Effects of the butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on the arylamines N-acetyltransferase activity in rat white blood cells. aniline 88-98 N-acetyltransferase 1 Rattus norvegicus 99-118 10205671-0 1999 Purification of cytochrome P-450 from pig testis by aniline-sepharose 4B and isoelectric focusing. aniline 52-59 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 16-32 9929513-2 1999 Two genes (NAT1, NAT2) have been identified and allelic variation in NAT2 has been associated with arylamine toxicity in adults. aniline 99-108 N-acetyl transferase 1 Mus musculus 11-15 9929513-2 1999 Two genes (NAT1, NAT2) have been identified and allelic variation in NAT2 has been associated with arylamine toxicity in adults. aniline 99-108 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 17-21 9929513-2 1999 Two genes (NAT1, NAT2) have been identified and allelic variation in NAT2 has been associated with arylamine toxicity in adults. aniline 99-108 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 69-73