PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24802986-0	2014	In vitro inhibitory effects of scutellarin on six human/rat cytochrome P450 enzymes and P-glycoprotein.	scutellarin	31-42	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-75
24802986-0	2014	In vitro inhibitory effects of scutellarin on six human/rat cytochrome P450 enzymes and P-glycoprotein.	scutellarin	31-42	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	88-102
24802986-3	2014	In this study, the in vitro inhibitory effects of scutellarin on six major human CYPs (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and six rat CYPs (CYP1A2, CYP2C7, CYP2C11, CYP2C79, CYP2D4, and CYP3A2) activities were examined by using liquid chromatography-tandem mass spectrometry.	scutellarin	50-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	87-93
24802986-3	2014	In this study, the in vitro inhibitory effects of scutellarin on six major human CYPs (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and six rat CYPs (CYP1A2, CYP2C7, CYP2C11, CYP2C79, CYP2D4, and CYP3A2) activities were examined by using liquid chromatography-tandem mass spectrometry.	scutellarin	50-61	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-109
24802986-4	2014	Meanwhile, the inhibitory effects of scutellarin on P-gp activity were examined on a human metastatic malignant melanoma cell line WM-266-4 by calcein-AM fluorometry screening assay.	scutellarin	37-48	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
24802986-5	2014	Results demonstrated that scutellarin showed negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 muM, whereas it showed values of 63.8 muM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 muM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively.	scutellarin	26-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-95
24802986-5	2014	Results demonstrated that scutellarin showed negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 muM, whereas it showed values of 63.8 muM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 muM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively.	scutellarin	26-37	latexin	Homo sapiens	186-189
24802986-5	2014	Results demonstrated that scutellarin showed negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 muM, whereas it showed values of 63.8 muM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 muM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively.	scutellarin	26-37	latexin	Homo sapiens	224-227
24802986-5	2014	Results demonstrated that scutellarin showed negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 muM, whereas it showed values of 63.8 muM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 muM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively.	scutellarin	26-37	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	232-239
24802986-5	2014	Results demonstrated that scutellarin showed negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 muM, whereas it showed values of 63.8 muM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 muM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively.	scutellarin	26-37	latexin	Homo sapiens	224-227
24802986-5	2014	Results demonstrated that scutellarin showed negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 muM, whereas it showed values of 63.8 muM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 muM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively.	scutellarin	26-37	cytochrome P450, family 2, subfamily c, polypeptide 7	Rattus norvegicus	293-299
24802986-5	2014	Results demonstrated that scutellarin showed negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 muM, whereas it showed values of 63.8 muM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 muM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively.	scutellarin	26-37	cytochrome P450, family 2, subfamily c, polypeptide 79	Rattus norvegicus	304-311
24802986-6	2014	Scutellarin also showed weak inhibitory effect on P-gp.	scutellarin	0-11	ATP binding cassette subfamily B member 1	Homo sapiens	50-54
23620377-3	2014	The present study aims to compare the inhibition potential of scutellarin and scutellarein towards several important UDP-glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7.	scutellarin	62-73	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	117-144
23620377-3	2014	The present study aims to compare the inhibition potential of scutellarin and scutellarein towards several important UDP-glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7.	scutellarin	62-73	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	146-149
23620377-3	2014	The present study aims to compare the inhibition potential of scutellarin and scutellarein towards several important UDP-glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7.	scutellarin	62-73	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	171-177
23620377-3	2014	The present study aims to compare the inhibition potential of scutellarin and scutellarein towards several important UDP-glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7.	scutellarin	62-73	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	179-185
23620377-3	2014	The present study aims to compare the inhibition potential of scutellarin and scutellarein towards several important UDP-glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7.	scutellarin	62-73	UDP glucuronosyltransferase family 1 member A9	Rattus norvegicus	187-193
23620377-3	2014	The present study aims to compare the inhibition potential of scutellarin and scutellarein towards several important UDP-glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7.	scutellarin	62-73	UDP glucuronosyltransferase family 2 member B7	Rattus norvegicus	198-204
22228482-0	2012	Scutellarin inhibits cytochrome P450 isoenzyme 1A2 (CYP1A2) in rats.	scutellarin	0-11	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	21-50
23192830-0	2013	Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway.	scutellarin	0-11	signal transducer and activator of transcription 3	Homo sapiens	76-81
23192830-7	2013	Western blot analysis displayed that STAT3 protein was obviously decreased in Scutellarin-treated HepG2 cells.	scutellarin	78-89	signal transducer and activator of transcription 3	Homo sapiens	37-42
23192830-8	2013	Furthermore, STAT3 transcriptional targets Bcl-XL and Mcl-1 were also downregulated in HepG2 cells treated by Scutellarin.	scutellarin	110-121	signal transducer and activator of transcription 3	Homo sapiens	13-18
23192830-8	2013	Furthermore, STAT3 transcriptional targets Bcl-XL and Mcl-1 were also downregulated in HepG2 cells treated by Scutellarin.	scutellarin	110-121	BCL2 like 1	Homo sapiens	43-49
23192830-8	2013	Furthermore, STAT3 transcriptional targets Bcl-XL and Mcl-1 were also downregulated in HepG2 cells treated by Scutellarin.	scutellarin	110-121	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	54-59
23192830-9	2013	In summary, we found that Scutellarin was able to inhibit the proliferation and induce the apoptosis of HepG2 cells via a STAT3 signal pathway, which provided evident support for developing Scutellarin as an alternative treatment for liver cancer.	scutellarin	26-37	signal transducer and activator of transcription 3	Homo sapiens	122-127
23192830-9	2013	In summary, we found that Scutellarin was able to inhibit the proliferation and induce the apoptosis of HepG2 cells via a STAT3 signal pathway, which provided evident support for developing Scutellarin as an alternative treatment for liver cancer.	scutellarin	190-201	signal transducer and activator of transcription 3	Homo sapiens	122-127
23546449-7	2013	Our in vitro and in vivo studies have shown that scutellarin reduces the expression of MMP-2 and -9, and integrin alphavbeta6 in SAS cells, possibly through the regulation of expression of transcription factor AP-1.	scutellarin	49-60	matrix metallopeptidase 2	Homo sapiens	87-99
23546449-7	2013	Our in vitro and in vivo studies have shown that scutellarin reduces the expression of MMP-2 and -9, and integrin alphavbeta6 in SAS cells, possibly through the regulation of expression of transcription factor AP-1.	scutellarin	49-60	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	210-214
23462368-5	2013	Twelve excipients decreased efflux ratio of scutellarin in Caco-2 model, among them six excipients showed inhibition effect on MRP2 in MRP2 transport model.	scutellarin	44-55	ATP binding cassette subfamily C member 2	Homo sapiens	127-131
23462368-5	2013	Twelve excipients decreased efflux ratio of scutellarin in Caco-2 model, among them six excipients showed inhibition effect on MRP2 in MRP2 transport model.	scutellarin	44-55	ATP binding cassette subfamily C member 2	Homo sapiens	135-139
24223475-2	2013	This study aimed to investigate the effects of scutellarin (administered by oral gavage daily for 2 weeks) on brain TLR4/nuclear factor kappa B-(NF- kappa B-) mediated inflammation and blood pressure in renovascular hypertensive (using the 2-kidney, 2-clip method) rats.	scutellarin	47-58	toll-like receptor 4	Rattus norvegicus	116-120
24223475-6	2013	Furthermore, scutellarin significantly reduced the expression of TLR4, NF- kappa B p65, TNF- alpha , IL-1 beta , IL-18, Bax and cleaved-caspase-3 p17, and increased the expression of Mcl1.	scutellarin	13-24	toll-like receptor 4	Rattus norvegicus	65-69
24223475-6	2013	Furthermore, scutellarin significantly reduced the expression of TLR4, NF- kappa B p65, TNF- alpha , IL-1 beta , IL-18, Bax and cleaved-caspase-3 p17, and increased the expression of Mcl1.	scutellarin	13-24	synaptotagmin 1	Rattus norvegicus	83-86
24223475-6	2013	Furthermore, scutellarin significantly reduced the expression of TLR4, NF- kappa B p65, TNF- alpha , IL-1 beta , IL-18, Bax and cleaved-caspase-3 p17, and increased the expression of Mcl1.	scutellarin	13-24	tumor necrosis factor	Rattus norvegicus	88-98
24223475-6	2013	Furthermore, scutellarin significantly reduced the expression of TLR4, NF- kappa B p65, TNF- alpha , IL-1 beta , IL-18, Bax and cleaved-caspase-3 p17, and increased the expression of Mcl1.	scutellarin	13-24	interleukin 1 beta	Rattus norvegicus	101-110
24223475-6	2013	Furthermore, scutellarin significantly reduced the expression of TLR4, NF- kappa B p65, TNF- alpha , IL-1 beta , IL-18, Bax and cleaved-caspase-3 p17, and increased the expression of Mcl1.	scutellarin	13-24	interleukin 18	Rattus norvegicus	113-118
24223475-6	2013	Furthermore, scutellarin significantly reduced the expression of TLR4, NF- kappa B p65, TNF- alpha , IL-1 beta , IL-18, Bax and cleaved-caspase-3 p17, and increased the expression of Mcl1.	scutellarin	13-24	BCL2 associated X, apoptosis regulator	Rattus norvegicus	120-123
24223475-6	2013	Furthermore, scutellarin significantly reduced the expression of TLR4, NF- kappa B p65, TNF- alpha , IL-1 beta , IL-18, Bax and cleaved-caspase-3 p17, and increased the expression of Mcl1.	scutellarin	13-24	MCL1 apoptosis regulator, BCL2 family member	Rattus norvegicus	183-187
22582896-5	2012	A mechanism study showed that scutellarin at doses of less than 10 muM induced cell cycle arrest at G0/G1 transition without the induction of cell apoptosis, which was accompanied by down-regulation of cyclin D1 and CDK4 expression.	scutellarin	30-41	latexin	Homo sapiens	67-70
22582896-5	2012	A mechanism study showed that scutellarin at doses of less than 10 muM induced cell cycle arrest at G0/G1 transition without the induction of cell apoptosis, which was accompanied by down-regulation of cyclin D1 and CDK4 expression.	scutellarin	30-41	cyclin D1	Homo sapiens	202-211
22582896-5	2012	A mechanism study showed that scutellarin at doses of less than 10 muM induced cell cycle arrest at G0/G1 transition without the induction of cell apoptosis, which was accompanied by down-regulation of cyclin D1 and CDK4 expression.	scutellarin	30-41	cyclin dependent kinase 4	Homo sapiens	216-220
22822035-0	2012	Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics.	scutellarin	57-68	solute carrier organic anion transporter family member 2B1	Homo sapiens	90-97
22822035-7	2012	Among the major hepatic anion uptake transporters, organic anion-transporting polypeptide (OATP) 2B1 played a predominant role in the hepatic uptake of S-6-G and S-7-G and showed greater preference for S-7-G with higher affinity than S-6-G (K(m) values were 1.77 and 43.9 muM, respectively).	scutellarin	162-167	solute carrier organic anion transporter family member 2B1	Homo sapiens	51-100
22822035-7	2012	Among the major hepatic anion uptake transporters, organic anion-transporting polypeptide (OATP) 2B1 played a predominant role in the hepatic uptake of S-6-G and S-7-G and showed greater preference for S-7-G with higher affinity than S-6-G (K(m) values were 1.77 and 43.9 muM, respectively).	scutellarin	202-207	solute carrier organic anion transporter family member 2B1	Homo sapiens	51-100
22822035-7	2012	Among the major hepatic anion uptake transporters, organic anion-transporting polypeptide (OATP) 2B1 played a predominant role in the hepatic uptake of S-6-G and S-7-G and showed greater preference for S-7-G with higher affinity than S-6-G (K(m) values were 1.77 and 43.9 muM, respectively).	scutellarin	202-207	latexin	Homo sapiens	272-275
22822035-8	2012	Considering the low intrinsic permeability of S-6-G and S-7-G and the role of OATP2B1 in the hepatic clearance of such compounds, the selective hepatic uptake of S-7-G mediated by OATP2B1 is likely a key determinant for the much lower systemic exposure of S-7-G than S-6-G in humans.	scutellarin	162-167	solute carrier organic anion transporter family member 2B1	Homo sapiens	180-187
22822035-8	2012	Considering the low intrinsic permeability of S-6-G and S-7-G and the role of OATP2B1 in the hepatic clearance of such compounds, the selective hepatic uptake of S-7-G mediated by OATP2B1 is likely a key determinant for the much lower systemic exposure of S-7-G than S-6-G in humans.	scutellarin	162-167	solute carrier organic anion transporter family member 2B1	Homo sapiens	180-187
24422411-8	2013	The main pharmacokinetic parameters of scutellarin and scutellarin ethyl ester were as follows: Tmax Cmax and AUC0-t for scutellarin were (6 +/- 1.26) h, (321.55 +/-48.31) microg L-1 and (2 974 +/-753) h micro.g L-1; for scutellarin ethyl ester, Tmax, Cmax and AUC0-t were 0.5 h, (1 550.82 +/-219.75) +/- microg L- and (6 407 +/- 399) h microg L-1.	scutellarin	39-50	ribosomal protein L4	Rattus norvegicus	179-182
24422411-8	2013	The main pharmacokinetic parameters of scutellarin and scutellarin ethyl ester were as follows: Tmax Cmax and AUC0-t for scutellarin were (6 +/- 1.26) h, (321.55 +/-48.31) microg L-1 and (2 974 +/-753) h micro.g L-1; for scutellarin ethyl ester, Tmax, Cmax and AUC0-t were 0.5 h, (1 550.82 +/-219.75) +/- microg L- and (6 407 +/- 399) h microg L-1.	scutellarin	39-50	ribosomal protein L4	Rattus norvegicus	212-215
24422411-8	2013	The main pharmacokinetic parameters of scutellarin and scutellarin ethyl ester were as follows: Tmax Cmax and AUC0-t for scutellarin were (6 +/- 1.26) h, (321.55 +/-48.31) microg L-1 and (2 974 +/-753) h micro.g L-1; for scutellarin ethyl ester, Tmax, Cmax and AUC0-t were 0.5 h, (1 550.82 +/-219.75) +/- microg L- and (6 407 +/- 399) h microg L-1.	scutellarin	39-50	ribosomal protein L4	Rattus norvegicus	212-215
24422411-8	2013	The main pharmacokinetic parameters of scutellarin and scutellarin ethyl ester were as follows: Tmax Cmax and AUC0-t for scutellarin were (6 +/- 1.26) h, (321.55 +/-48.31) microg L-1 and (2 974 +/-753) h micro.g L-1; for scutellarin ethyl ester, Tmax, Cmax and AUC0-t were 0.5 h, (1 550.82 +/-219.75) +/- microg L- and (6 407 +/- 399) h microg L-1.	scutellarin	55-66	ribosomal protein L4	Rattus norvegicus	179-182
24422411-8	2013	The main pharmacokinetic parameters of scutellarin and scutellarin ethyl ester were as follows: Tmax Cmax and AUC0-t for scutellarin were (6 +/- 1.26) h, (321.55 +/-48.31) microg L-1 and (2 974 +/-753) h micro.g L-1; for scutellarin ethyl ester, Tmax, Cmax and AUC0-t were 0.5 h, (1 550.82 +/-219.75) +/- microg L- and (6 407 +/- 399) h microg L-1.	scutellarin	55-66	ribosomal protein L4	Rattus norvegicus	212-215
24422411-8	2013	The main pharmacokinetic parameters of scutellarin and scutellarin ethyl ester were as follows: Tmax Cmax and AUC0-t for scutellarin were (6 +/- 1.26) h, (321.55 +/-48.31) microg L-1 and (2 974 +/-753) h micro.g L-1; for scutellarin ethyl ester, Tmax, Cmax and AUC0-t were 0.5 h, (1 550.82 +/-219.75) +/- microg L- and (6 407 +/- 399) h microg L-1.	scutellarin	55-66	ribosomal protein L4	Rattus norvegicus	212-215
22228482-0	2012	Scutellarin inhibits cytochrome P450 isoenzyme 1A2 (CYP1A2) in rats.	scutellarin	0-11	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	52-58
22228482-5	2012	The present study investigated the in vitro and in vivo effects of scutellarin on cytochrome P450 1A2 (CYP 1A2) metabolism.	scutellarin	67-78	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	82-101
22228482-5	2012	The present study investigated the in vitro and in vivo effects of scutellarin on cytochrome P450 1A2 (CYP 1A2) metabolism.	scutellarin	67-78	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	103-110
22228482-13	2012	Scutellarin at 30 mg/kg also weakly inhibited CYP1A2 activity, in accordance with our in vitro study.	scutellarin	0-11	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	46-52
22228482-14	2012	Thus, the results indicate that CYP1A2 is inhibited directly, but weakly, by scutellarin in vivo, and provide useful information on the safe and effective use of scutellarin in clinical practice.	scutellarin	77-88	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	32-38
22228482-14	2012	Thus, the results indicate that CYP1A2 is inhibited directly, but weakly, by scutellarin in vivo, and provide useful information on the safe and effective use of scutellarin in clinical practice.	scutellarin	162-173	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	32-38
21524691-8	2011	Moreover, Scutellarin also inhibited interferon-gamma (IFN-gamma)-induced NO production, iNOS mRNA expression and transcription factor signal transducer and activator of transcription 1alpha (STAT1alpha) activation.	scutellarin	10-21	interferon gamma	Mus musculus	37-64
21524691-5	2011	We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line.	scutellarin	17-28	tumor necrosis factor	Rattus norvegicus	139-166
22092277-1	2012	The aims of the present study were to explore the effects of: (i) scutellarin (Scu) on protein kinase C (PKC) translocation caused by diabetic conditions in diabetic rat thoracic aorta; and (ii) phorbol-12-myristate-13-acetate (PMA) treatment of cultured thoracic aortic smooth muscle cells.	scutellarin	66-77	protein kinase C, alpha	Rattus norvegicus	105-108
21524691-8	2011	Moreover, Scutellarin also inhibited interferon-gamma (IFN-gamma)-induced NO production, iNOS mRNA expression and transcription factor signal transducer and activator of transcription 1alpha (STAT1alpha) activation.	scutellarin	10-21	nitric oxide synthase 2, inducible	Mus musculus	89-93
21655064-0	2011	Effects of scutellarin on MUC5AC mucin production induced by human neutrophil elastase or interleukin 13 on airway epithelial cells.	scutellarin	11-22	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	26-32
21524691-5	2011	We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line.	scutellarin	17-28	interleukin 1 beta	Rattus norvegicus	323-331
21655064-0	2011	Effects of scutellarin on MUC5AC mucin production induced by human neutrophil elastase or interleukin 13 on airway epithelial cells.	scutellarin	11-22	elastase, neutrophil expressed	Homo sapiens	67-86
21655064-2	2011	The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism.	scutellarin	45-56	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	60-66
21655064-8	2011	The phosphorylation of PKC and ERK1/2 was attenuated after treatment with scutellarin, whereas STAT6 was not significantly affected.	scutellarin	74-85	mitogen-activated protein kinase 3	Homo sapiens	31-37
21823425-0	2011	[Effect of scutellarin on expressions of nicotinic acetylcholine receptor protein and mRNA in the brains of dementia rats].	scutellarin	11-22	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	41-73
21823425-1	2011	OBJECTIVE: To observe the effect of Scutellarin (Scu) on expressions of nicotinic acetylcholine receptor (nAChR) subunit protein and mRNA in dementia rats, and to study its possible mechanism on dementia.	scutellarin	36-47	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	72-104
21823425-1	2011	OBJECTIVE: To observe the effect of Scutellarin (Scu) on expressions of nicotinic acetylcholine receptor (nAChR) subunit protein and mRNA in dementia rats, and to study its possible mechanism on dementia.	scutellarin	36-47	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	106-111
21823425-1	2011	OBJECTIVE: To observe the effect of Scutellarin (Scu) on expressions of nicotinic acetylcholine receptor (nAChR) subunit protein and mRNA in dementia rats, and to study its possible mechanism on dementia.	scutellarin	36-39	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	72-104
21823425-1	2011	OBJECTIVE: To observe the effect of Scutellarin (Scu) on expressions of nicotinic acetylcholine receptor (nAChR) subunit protein and mRNA in dementia rats, and to study its possible mechanism on dementia.	scutellarin	36-39	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	106-111
21626779-7	2011	The drugs may compete for oatp2 mediated transport pathway consisted in the uptake of scutellarin in liver.	scutellarin	86-97	solute carrier organic anion transporter family, member 1a4	Mus musculus	26-31
21524691-5	2011	We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line.	scutellarin	17-28	tumor necrosis factor	Rattus norvegicus	168-176
21524691-5	2011	We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line.	scutellarin	17-28	interleukin 1 beta	Rattus norvegicus	179-196
21524691-5	2011	We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line.	scutellarin	17-28	interleukin 1 beta	Rattus norvegicus	198-206
21524691-5	2011	We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line.	scutellarin	17-28	nitric oxide synthase 2	Rattus norvegicus	269-300
21524691-5	2011	We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line.	scutellarin	17-28	nitric oxide synthase 2	Rattus norvegicus	302-306
21524691-5	2011	We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line.	scutellarin	17-28	tumor necrosis factor	Rattus norvegicus	309-317
21823483-6	2011	After treated with Scutellarin, learning and memory ability of rats with dementia was improved; The pathologic changes were alleviated; The activity of SOD was up-regulation and the activity of MAO was decreased; Neuronal apoptosis percentage was declined.	scutellarin	19-30	monoamine oxidase A	Rattus norvegicus	194-197
20942814-0	2011	Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFbeta1 expression and activation of p38-MAPK and ERK1/2.	scutellarin	0-11	transforming growth factor, beta 1	Rattus norvegicus	99-107
20942814-0	2011	Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFbeta1 expression and activation of p38-MAPK and ERK1/2.	scutellarin	0-11	mitogen activated protein kinase 14	Rattus norvegicus	137-140
20942814-0	2011	Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFbeta1 expression and activation of p38-MAPK and ERK1/2.	scutellarin	0-11	mitogen activated protein kinase 3	Rattus norvegicus	150-156
20052460-0	2010	Scutellarin exerts its anti-hypertrophic effects via suppressing the Ca2+-mediated calcineurin and CaMKII signaling pathways.	scutellarin	0-11	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	99-105
20052460-7	2010	The expression of calcium downstream effectors calcineurin and phosphorylated calmodulin kinase II (CaMKII) were significantly suppressed by scutellarin.	scutellarin	141-152	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	78-98
20052460-7	2010	The expression of calcium downstream effectors calcineurin and phosphorylated calmodulin kinase II (CaMKII) were significantly suppressed by scutellarin.	scutellarin	141-152	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	100-106
20052460-8	2010	Our study indicated that scutellarin exerts its anti-hypertrophic activity via suppressing the Ca(2+)-mediated calcineurin and CaMKII pathways, which supports the observation that clinical application of scutellarin is beneficial for cardiovascular disease patients.	scutellarin	25-36	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	127-133
20052460-8	2010	Our study indicated that scutellarin exerts its anti-hypertrophic activity via suppressing the Ca(2+)-mediated calcineurin and CaMKII pathways, which supports the observation that clinical application of scutellarin is beneficial for cardiovascular disease patients.	scutellarin	204-215	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	127-133
18271309-0	2008	Mrp2-related efflux of scutellarin in the intestinal absorption in rats.	scutellarin	23-34	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-4
19661313-0	2009	Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation.	scutellarin	0-11	caspase 6	Homo sapiens	80-89
18758143-8	2008	Furthermore, although oral administration of scutellarin (10 and 50 mg/kg) did not produce significant antihyperglycemic action, it lowered the serum MCP-1 levels significantly in alloxan-induced diabetic mice.	scutellarin	45-56	chemokine (C-C motif) ligand 2	Mus musculus	150-155
20390762-7	2010	Pretreatment with 25 and 50 mg/kg of scutellarin significantly reduced lung injury induced by LPS, which expressed in the decrease in lung morphological lesions, serum NO2(-)/NO3(-), TNF-alpha levels, lactate dehydrogenase release, and total protein in the lavage fluid of bronchoalveolar of the lung.	scutellarin	37-48	tumor necrosis factor	Mus musculus	183-192
19533578-3	2009	Scutellarin showed the estrogenic effects by activating the estrogen responsive elements and phosphorylation of estrogen receptor alpha in cultured MCF-7 cells: the activation was in a dose-dependent manner.	scutellarin	0-11	estrogen receptor 1	Homo sapiens	112-135
18271309-8	2008	The efflux of Mrp2, not P-gp, in the intestinal of the rats may be one of the reasons that lead to the low oral bioavailability of scutellarin.	scutellarin	131-142	ATP binding cassette subfamily C member 2	Rattus norvegicus	14-18
18442013-6	2007	These results demonstrate that scutellarin can protect PC12 cells from cobalt chloride induced apoptosis by scavenging ROS, inhibiting p38 phosphorylation, up-regulating Bcl-XL expression and decreasing caspase-3 activity, and may reduce the cellular damage in pathological conditions associated with hypoxia-mediated neuronal injury.	scutellarin	31-42	mitogen activated protein kinase 14	Rattus norvegicus	135-138
18442013-6	2007	These results demonstrate that scutellarin can protect PC12 cells from cobalt chloride induced apoptosis by scavenging ROS, inhibiting p38 phosphorylation, up-regulating Bcl-XL expression and decreasing caspase-3 activity, and may reduce the cellular damage in pathological conditions associated with hypoxia-mediated neuronal injury.	scutellarin	31-42	Bcl2-like 1	Rattus norvegicus	170-176
18442013-6	2007	These results demonstrate that scutellarin can protect PC12 cells from cobalt chloride induced apoptosis by scavenging ROS, inhibiting p38 phosphorylation, up-regulating Bcl-XL expression and decreasing caspase-3 activity, and may reduce the cellular damage in pathological conditions associated with hypoxia-mediated neuronal injury.	scutellarin	31-42	caspase 3	Rattus norvegicus	203-212
34750765-10	2021	In conclusion, our findings suggested that SCU possesses the ability of protecting brain cells against CIR injury through vascular endothelium protection and PKG signal.	scutellarin	43-46	corepressor interacting with RBPJ, 1	Rattus norvegicus	103-106
17883942-0	2007	Effects of scutellarin on PKCgamma in PC12 cell injury induced by oxygen and glucose deprivation.	scutellarin	11-22	protein kinase C, gamma	Rattus norvegicus	26-34
15661569-9	2005	Results also showed that hydrogen peroxide increased activity of cNOS, which was markedly inhibited by scutellarin.	scutellarin	103-114	nitric oxide synthase 3	Rattus norvegicus	65-69
33236146-5	2021	The present study investigated whether scutellarin can mediate the release of inflammatory cytokines, the expression of collagen- and cholesterol-related proteins, and regulate the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway in a cell model of OA.	scutellarin	39-50	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	181-206
33236146-5	2021	The present study investigated whether scutellarin can mediate the release of inflammatory cytokines, the expression of collagen- and cholesterol-related proteins, and regulate the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway in a cell model of OA.	scutellarin	39-50	AKT serine/threonine kinase 1	Homo sapiens	214-217
33236146-5	2021	The present study investigated whether scutellarin can mediate the release of inflammatory cytokines, the expression of collagen- and cholesterol-related proteins, and regulate the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway in a cell model of OA.	scutellarin	39-50	mechanistic target of rapamycin kinase	Homo sapiens	218-247
33236146-5	2021	The present study investigated whether scutellarin can mediate the release of inflammatory cytokines, the expression of collagen- and cholesterol-related proteins, and regulate the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway in a cell model of OA.	scutellarin	39-50	mechanistic target of rapamycin kinase	Homo sapiens	249-253
33236146-9	2021	In addition, scutellarin downregulated the expression levels of cholesterol 25-hydroxylase and cytochrome P450 family 7 subfamily B polypeptide 1, but upregulated the expression of apolipoprotein A-1 and adenosine triphosphate-binding cassette transporter A1.	scutellarin	13-24	apolipoprotein A1	Homo sapiens	181-199
33236146-10	2021	The IL-1beta-induced increase in the expression of IL-6 was decreased by treatment with scutellarin; however, scutellarin did not alter the expression of C-reactive protein and tumor necrosis factor-alpha.	scutellarin	88-99	interleukin 1 alpha	Homo sapiens	4-12
33236146-10	2021	The IL-1beta-induced increase in the expression of IL-6 was decreased by treatment with scutellarin; however, scutellarin did not alter the expression of C-reactive protein and tumor necrosis factor-alpha.	scutellarin	88-99	interleukin 6	Homo sapiens	51-55
34624394-5	2021	In addition, scutellarin inhibited LPS-induced elevation of TNFalpha, IL-1beta, IL-6 and iNOS, and reversed the downregulation of IL-4 and BDNF in astrocytes in vitro.	scutellarin	13-24	tumor necrosis factor	Mus musculus	60-68
34624394-5	2021	In addition, scutellarin inhibited LPS-induced elevation of TNFalpha, IL-1beta, IL-6 and iNOS, and reversed the downregulation of IL-4 and BDNF in astrocytes in vitro.	scutellarin	13-24	interleukin 1 alpha	Mus musculus	70-78
34624394-5	2021	In addition, scutellarin inhibited LPS-induced elevation of TNFalpha, IL-1beta, IL-6 and iNOS, and reversed the downregulation of IL-4 and BDNF in astrocytes in vitro.	scutellarin	13-24	interleukin 6	Mus musculus	80-84
34624394-5	2021	In addition, scutellarin inhibited LPS-induced elevation of TNFalpha, IL-1beta, IL-6 and iNOS, and reversed the downregulation of IL-4 and BDNF in astrocytes in vitro.	scutellarin	13-24	nitric oxide synthase 2, inducible	Mus musculus	89-93
34624394-5	2021	In addition, scutellarin inhibited LPS-induced elevation of TNFalpha, IL-1beta, IL-6 and iNOS, and reversed the downregulation of IL-4 and BDNF in astrocytes in vitro.	scutellarin	13-24	interleukin 4	Mus musculus	130-134
34624394-5	2021	In addition, scutellarin inhibited LPS-induced elevation of TNFalpha, IL-1beta, IL-6 and iNOS, and reversed the downregulation of IL-4 and BDNF in astrocytes in vitro.	scutellarin	13-24	brain derived neurotrophic factor	Mus musculus	139-143
34624394-6	2021	Furthermore, the activated TLR4/NF-kappaB pathway in LPS-treated astrocytes was suppressed by scutellarin.	scutellarin	94-105	toll-like receptor 4	Mus musculus	27-31
34624394-6	2021	Furthermore, the activated TLR4/NF-kappaB pathway in LPS-treated astrocytes was suppressed by scutellarin.	scutellarin	94-105	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	32-41
34624394-7	2021	Collectively, these results suggest that scutellarin ameliorates depression-like behaviors induced by neuroinflammation partially through inhibiting the TLR4/NF-kappaB pathway in astrocytes.	scutellarin	41-52	toll-like receptor 4	Mus musculus	153-157
34624394-7	2021	Collectively, these results suggest that scutellarin ameliorates depression-like behaviors induced by neuroinflammation partially through inhibiting the TLR4/NF-kappaB pathway in astrocytes.	scutellarin	41-52	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
16297343-8	2005	When rats were pretreated with scutellarin (50 or 75 mg/kg), upregulation of eNOS expression and downregulation of VEGF, bFGF, and iNOS expression was observed, whereas scutellarin had no effect on nNOS expression.	scutellarin	31-42	nitric oxide synthase 3	Rattus norvegicus	77-81
16297343-8	2005	When rats were pretreated with scutellarin (50 or 75 mg/kg), upregulation of eNOS expression and downregulation of VEGF, bFGF, and iNOS expression was observed, whereas scutellarin had no effect on nNOS expression.	scutellarin	31-42	vascular endothelial growth factor A	Rattus norvegicus	115-119
16297343-8	2005	When rats were pretreated with scutellarin (50 or 75 mg/kg), upregulation of eNOS expression and downregulation of VEGF, bFGF, and iNOS expression was observed, whereas scutellarin had no effect on nNOS expression.	scutellarin	31-42	fibroblast growth factor 2	Rattus norvegicus	121-125
16297343-8	2005	When rats were pretreated with scutellarin (50 or 75 mg/kg), upregulation of eNOS expression and downregulation of VEGF, bFGF, and iNOS expression was observed, whereas scutellarin had no effect on nNOS expression.	scutellarin	31-42	nitric oxide synthase 2	Rattus norvegicus	131-135
16297343-8	2005	When rats were pretreated with scutellarin (50 or 75 mg/kg), upregulation of eNOS expression and downregulation of VEGF, bFGF, and iNOS expression was observed, whereas scutellarin had no effect on nNOS expression.	scutellarin	31-42	nitric oxide synthase 1	Rattus norvegicus	198-202
33236146-11	2021	The protein expression levels of AKT, phosphorylated (p)-AKT, mTOR and p-mTOR in the PI3K/AKT/mTOR signaling pathway were decreased in the IL-1beta-induced SW1353 cells following scutellarin treatment.	scutellarin	179-190	AKT serine/threonine kinase 1	Homo sapiens	33-36
33236146-11	2021	The protein expression levels of AKT, phosphorylated (p)-AKT, mTOR and p-mTOR in the PI3K/AKT/mTOR signaling pathway were decreased in the IL-1beta-induced SW1353 cells following scutellarin treatment.	scutellarin	179-190	interleukin 1 alpha	Homo sapiens	139-147
34859513-4	2022	Scu reduced intracellular lipid content and inhibited sterol regulatory element binding protein-1c (SREBP-1c)-mediated lipid synthesis and fatty acid translocase-mediated lipid uptake in HepG2 cells.	scutellarin	0-3	sterol regulatory element binding transcription factor 1	Homo sapiens	54-98
34859513-4	2022	Scu reduced intracellular lipid content and inhibited sterol regulatory element binding protein-1c (SREBP-1c)-mediated lipid synthesis and fatty acid translocase-mediated lipid uptake in HepG2 cells.	scutellarin	0-3	sterol regulatory element binding transcription factor 1	Homo sapiens	100-108
34859513-9	2022	These findings demonstrate that Scu ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing ER stress via the IRE1alpha/XBP1 pathway.	scutellarin	32-35	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	132-141
34859513-9	2022	These findings demonstrate that Scu ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing ER stress via the IRE1alpha/XBP1 pathway.	scutellarin	32-35	X-box binding protein 1	Homo sapiens	142-146
34750765-6	2021	Further studies suggested that SCU (10-1000 microM) dose-dependently induced relaxation in isolated BA rings which were significantly blocked by the cGMP dependent protein kinase (PKG) inhibitor Rp-8-Br-cGMPs (PKGI-rp, 4 microM).	scutellarin	31-34	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	164-178
34750765-6	2021	Further studies suggested that SCU (10-1000 microM) dose-dependently induced relaxation in isolated BA rings which were significantly blocked by the cGMP dependent protein kinase (PKG) inhibitor Rp-8-Br-cGMPs (PKGI-rp, 4 microM).	scutellarin	31-34	protein kinase cGMP-dependent 1	Rattus norvegicus	210-214
34750765-8	2021	The brain slice staining test in rats" model of middle cerebral artery occlusion (MCAO) induced CIR proved that the administration of SCU (45, 90 mg/kg, iv) significantly reduced the area of cerebral infarction.	scutellarin	134-137	corepressor interacting with RBPJ, 1	Rattus norvegicus	96-99
34750765-9	2021	The Western blot assay result showed that SCU (45 mg/kg, iv) increased brain PKG activity and PKG protein level after CIR surgery.	scutellarin	42-45	corepressor interacting with RBPJ, 1	Rattus norvegicus	118-121
34663387-5	2021	Besides, the mRNA level of growth-associated protein 43 (GAP43) in OGD neurons with Scu treatment was detected by quantitative real-time polymerase chain reaction (qRT-PCR).	scutellarin	84-87	growth associated protein 43	Rattus norvegicus	27-55
34663387-5	2021	Besides, the mRNA level of growth-associated protein 43 (GAP43) in OGD neurons with Scu treatment was detected by quantitative real-time polymerase chain reaction (qRT-PCR).	scutellarin	84-87	growth associated protein 43	Rattus norvegicus	57-62
34663387-6	2021	To further verify the role of GAP43 in Scu treatment, GAP43 siRNA and knockout were applied in vitro and in vivo.	scutellarin	39-42	growth associated protein 43	Rattus norvegicus	30-35
34663387-11	2021	And the expression of GAP43 was downregulated after OGD, but reversed by Scu administration.	scutellarin	73-76	growth associated protein 43	Rattus norvegicus	22-27
34663387-16	2021	CONCLUSIONS: Collectively, our findings revealed Scu treatment attenuated long-term neurological impairments after HI by suppressing neuronal death and enhancing neurite elongation through GAP43-dependent pathway.	scutellarin	49-52	growth associated protein 43	Rattus norvegicus	189-194
34255431-10	2021	CONCLUSIONS: The results of our study suggested that SCU promotes the anticancer effects induced by 125 I in NSCLC cells by downregulating the AKT/mTOR pathway and lays a foundation for future application of this combined treatment.	scutellarin	53-56	AKT serine/threonine kinase 1	Homo sapiens	143-146
34531475-18	2021	Our results from studying the mechanism of action show that E. breviscapus injection and Scutellarin inhibited the activation of MMP-9 by inhibiting the synthesis of iNOS, 3,5-dicaffeoylquinic acid inhibits the expression and activation of MMP-9 by inhibiting the activation of iNOS and reducing the generation of free radicals, thus reducing the degradation of important cytoskeleton connexin claudin-5 in the tight junction (TJ) structure by inhibiting the expression and activation of MMP-9.	scutellarin	89-100	claudin 5	Rattus norvegicus	394-403
34568005-0	2021	Combined Scutellarin and C18H17NO6 Imperils the Survival of Glioma: Partly Associated With the Repression of PSEN1/PI3K-AKT Signaling Axis.	scutellarin	9-20	presenilin 1	Homo sapiens	109-114
34568005-0	2021	Combined Scutellarin and C18H17NO6 Imperils the Survival of Glioma: Partly Associated With the Repression of PSEN1/PI3K-AKT Signaling Axis.	scutellarin	9-20	AKT serine/threonine kinase 1	Homo sapiens	120-123
34568005-14	2021	Accordingly, we concluded that scutellarin and its combination with C18H17NO6 suppressed the proliferation/growth and migration and induced the apoptosis of glioma, in which the mechanism might be associated with the repression of PSEN1/PI3K-AKT signaling axis.	scutellarin	31-42	presenilin 1	Homo sapiens	231-236
34568005-14	2021	Accordingly, we concluded that scutellarin and its combination with C18H17NO6 suppressed the proliferation/growth and migration and induced the apoptosis of glioma, in which the mechanism might be associated with the repression of PSEN1/PI3K-AKT signaling axis.	scutellarin	31-42	AKT serine/threonine kinase 1	Homo sapiens	242-245
34568577-0	2021	Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-beta1/smad2/ROS/caspase-3 pathway.	scutellarin	0-11	transforming growth factor beta 1	Homo sapiens	69-101
34568577-0	2021	Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-beta1/smad2/ROS/caspase-3 pathway.	scutellarin	0-11	SMAD family member 2	Homo sapiens	102-107
34568577-0	2021	Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-beta1/smad2/ROS/caspase-3 pathway.	scutellarin	0-11	caspase 3	Homo sapiens	112-121
34568577-7	2021	Moreover, scutellarin-induced intracellular ROS production and cleaved caspase-3 expression were inhibited by blocking the TGF-beta1/smad2 pathway with SB431542.	scutellarin	10-21	caspase 3	Homo sapiens	71-80
34568577-7	2021	Moreover, scutellarin-induced intracellular ROS production and cleaved caspase-3 expression were inhibited by blocking the TGF-beta1/smad2 pathway with SB431542.	scutellarin	10-21	transforming growth factor beta 1	Homo sapiens	123-132
34568577-7	2021	Moreover, scutellarin-induced intracellular ROS production and cleaved caspase-3 expression were inhibited by blocking the TGF-beta1/smad2 pathway with SB431542.	scutellarin	10-21	SMAD family member 2	Homo sapiens	133-138
34568577-9	2021	Our study indicated that scutellarin induced A549 cell apoptosis via the TGF-beta1/smad2/ROS/caspase-3 pathway.	scutellarin	25-36	transforming growth factor beta 1	Homo sapiens	73-82
34568577-9	2021	Our study indicated that scutellarin induced A549 cell apoptosis via the TGF-beta1/smad2/ROS/caspase-3 pathway.	scutellarin	25-36	SMAD family member 2	Homo sapiens	83-88
34568577-9	2021	Our study indicated that scutellarin induced A549 cell apoptosis via the TGF-beta1/smad2/ROS/caspase-3 pathway.	scutellarin	25-36	caspase 3	Homo sapiens	93-102
34118224-4	2021	Besides, Scutellarin attenuated mouse serum concentrations of TNF-alpha and IL-6, heightened Bax expression and diminished B-cell lymphoma-2 (Bcl-2) level in CAC tissues of mice, through down-regulating Wnt/beta-catenin signaling cascade.	scutellarin	9-20	tumor necrosis factor	Mus musculus	62-71
34118224-4	2021	Besides, Scutellarin attenuated mouse serum concentrations of TNF-alpha and IL-6, heightened Bax expression and diminished B-cell lymphoma-2 (Bcl-2) level in CAC tissues of mice, through down-regulating Wnt/beta-catenin signaling cascade.	scutellarin	9-20	interleukin 6	Mus musculus	76-80
34118224-4	2021	Besides, Scutellarin attenuated mouse serum concentrations of TNF-alpha and IL-6, heightened Bax expression and diminished B-cell lymphoma-2 (Bcl-2) level in CAC tissues of mice, through down-regulating Wnt/beta-catenin signaling cascade.	scutellarin	9-20	BCL2-associated X protein	Mus musculus	93-96
34118224-4	2021	Besides, Scutellarin attenuated mouse serum concentrations of TNF-alpha and IL-6, heightened Bax expression and diminished B-cell lymphoma-2 (Bcl-2) level in CAC tissues of mice, through down-regulating Wnt/beta-catenin signaling cascade.	scutellarin	9-20	B cell leukemia/lymphoma 2	Mus musculus	142-147
34118224-4	2021	Besides, Scutellarin attenuated mouse serum concentrations of TNF-alpha and IL-6, heightened Bax expression and diminished B-cell lymphoma-2 (Bcl-2) level in CAC tissues of mice, through down-regulating Wnt/beta-catenin signaling cascade.	scutellarin	9-20	catenin (cadherin associated protein), beta 1	Mus musculus	207-219
34255431-10	2021	CONCLUSIONS: The results of our study suggested that SCU promotes the anticancer effects induced by 125 I in NSCLC cells by downregulating the AKT/mTOR pathway and lays a foundation for future application of this combined treatment.	scutellarin	53-56	mechanistic target of rapamycin kinase	Homo sapiens	147-151
34421606-6	2021	In this study, transcriptomics combined with nontargeted metabolomics and 16S rRNA amplicon sequencing were performed to elucidate the functional mechanisms of SCU in carbon tetrachloride (CCl4)-induced liver injury in mice.	scutellarin	160-163	chemokine (C-C motif) ligand 4	Mus musculus	189-193
34421606-7	2021	The results showed that SCU exerted potential hepatoprotective effects against CCl4-induced liver injury by repressing CYP2E1 and IkappaBalpha/NF-kappaB signaling pathways, modulating the gut microbiota (especially enriching Lactobacillus), and regulating the endogenous metabolites involved in lipid metabolism and bile acid homeostasis.	scutellarin	24-27	chemokine (C-C motif) ligand 4	Mus musculus	79-83
34421606-7	2021	The results showed that SCU exerted potential hepatoprotective effects against CCl4-induced liver injury by repressing CYP2E1 and IkappaBalpha/NF-kappaB signaling pathways, modulating the gut microbiota (especially enriching Lactobacillus), and regulating the endogenous metabolites involved in lipid metabolism and bile acid homeostasis.	scutellarin	24-27	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	119-125
34421606-7	2021	The results showed that SCU exerted potential hepatoprotective effects against CCl4-induced liver injury by repressing CYP2E1 and IkappaBalpha/NF-kappaB signaling pathways, modulating the gut microbiota (especially enriching Lactobacillus), and regulating the endogenous metabolites involved in lipid metabolism and bile acid homeostasis.	scutellarin	24-27	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	130-142
35340266-0	2022	Corrigendum: Combined Scutellarin and C18H17NO6 Imperils the Survival of Glioma: Partly Associated With the Repression of PSEN1/PI3K-AKT Signaling Axis.	scutellarin	22-33	presenilin 1	Homo sapiens	122-127
35366826-11	2022	Finally, three compounds for the treatment of glaucoma were obtained in the TCMs database: acetylsalicylic acid, 7-o-methylisomucitol and scutellarin which were applied to molecular docking with the diagnostic biomarker ENO2.	scutellarin	138-149	enolase 2	Homo sapiens	220-224
35263019-6	2022	Alcohol treatment caused excessive lipid peroxidation product accumulation of MDA, restrained the activity of antioxidant enzyme CAT, induced HO-1 expression in the colon, whereas low dose SCU treatment significantly down-regulated the MDA level, enhanced the CAT level, and accelerated HO-1 signals.	scutellarin	189-192	catalase	Mus musculus	129-132
35263019-6	2022	Alcohol treatment caused excessive lipid peroxidation product accumulation of MDA, restrained the activity of antioxidant enzyme CAT, induced HO-1 expression in the colon, whereas low dose SCU treatment significantly down-regulated the MDA level, enhanced the CAT level, and accelerated HO-1 signals.	scutellarin	189-192	catalase	Mus musculus	260-263
34078809-0	2021	Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway.	scutellarin	0-11	phosphatase and tensin homolog	Homo sapiens	83-87
34078809-11	2021	Besides, Scu enhanced the expression of PTEN while reduced the phosphorylated level of PI3K.	scutellarin	9-12	phosphatase and tensin homolog	Homo sapiens	40-44
35340266-0	2022	Corrigendum: Combined Scutellarin and C18H17NO6 Imperils the Survival of Glioma: Partly Associated With the Repression of PSEN1/PI3K-AKT Signaling Axis.	scutellarin	22-33	AKT serine/threonine kinase 1	Homo sapiens	133-136
35228654-0	2022	Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFalpha-induced vascular endothelial barrier breakdown.	scutellarin	0-11	tumor necrosis factor	Homo sapiens	78-86
35151214-8	2022	RESULTS: Scutellarin significantly ameliorated AOM/DSS-caused CAC in mice and induced apoptosis in CAC tissues of mice, by inhibiting NF-kappaB (nuclear factor kappa B) -mediated inflammation and Hedgehog signaling axis.	scutellarin	9-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
35151214-8	2022	RESULTS: Scutellarin significantly ameliorated AOM/DSS-caused CAC in mice and induced apoptosis in CAC tissues of mice, by inhibiting NF-kappaB (nuclear factor kappa B) -mediated inflammation and Hedgehog signaling axis.	scutellarin	9-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-167
35080332-12	2022	In addition, the potentiation of scutellarin was shown to be mediated by phosphorylation of VEGF receptor 2 (VEGFR2) and mitogen-activated protein kinase (MAPK) signalling.	scutellarin	33-44	kinase insert domain receptor	Homo sapiens	92-107
35080332-12	2022	In addition, the potentiation of scutellarin was shown to be mediated by phosphorylation of VEGF receptor 2 (VEGFR2) and mitogen-activated protein kinase (MAPK) signalling.	scutellarin	33-44	kinase insert domain receptor	Homo sapiens	109-115
35002432-4	2022	On the other hand, treatment with scutellarin alone and in combination with a JNK inhibitor, SP600125, both significantly attenuated pulmonary edema as shown via reduced wet/dry lung mass ratios (1.7 +- 0.09 and 1.8 +- 0.23; P < 0.05, respectively).	scutellarin	34-45	mitogen-activated protein kinase 8	Rattus norvegicus	78-81
35002432-10	2022	Moreover, the combined effect of scutellarin and JNK inhibitor SP600125 on the levels of ROS and the SOD activity followed a similar trend to that of scutellarin alone albeit with a lower magnitude of change.	scutellarin	150-161	mitogen-activated protein kinase 8	Rattus norvegicus	49-52
35002432-12	2022	The effect of Scutellarin on broncho-alveolar lavage fluid (BALF) cytokine secretion The expression of interleukins-1beta, -18 and -6 in the broncho-alveolar lavage fluid were significantly upregulated by LPS infusion (P < 0.05).	scutellarin	14-25	interleukin 1 beta	Rattus norvegicus	103-133
33532184-4	2021	Scutellarin dose-dependently inhibited intracellular LPS-induced release of caspase-11p26 (indicative of caspase-11 activation) and generation of N-terminal fragment of gasdermin D (GSDMD-NT), leading to reduced pyroptosis.	scutellarin	0-11	gasdermin D	Mus musculus	169-180
33485979-5	2021	AIM OF THE STUDY: This aim of this study was to investigate the effect of Scu on human umbilical vein endothelial cells (HUVECs) injury induced by high glucose (HG), especially the regulation of PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy.	scutellarin	74-77	PTEN induced kinase 1	Homo sapiens	195-216
33485979-5	2021	AIM OF THE STUDY: This aim of this study was to investigate the effect of Scu on human umbilical vein endothelial cells (HUVECs) injury induced by high glucose (HG), especially the regulation of PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy.	scutellarin	74-77	PTEN induced kinase 1	Homo sapiens	218-223
33485979-13	2021	Meanwhile, Scu improved the overload of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and SOD2 protein expression, and reversed the collapse of mitochondrial membrane potential.	scutellarin	11-14	superoxide dismutase 2	Homo sapiens	111-115
33485979-16	2021	Moreover, the beneficial effects of Scu on HG-induced low expression of Parkin, overproduction of ROS, and over expressions of P62, Cyt.c and Cleaved caspase-3 were weakened by PINK1 gene knockdown.	scutellarin	36-39	sequestosome 1	Homo sapiens	127-130
33485979-16	2021	Moreover, the beneficial effects of Scu on HG-induced low expression of Parkin, overproduction of ROS, and over expressions of P62, Cyt.c and Cleaved caspase-3 were weakened by PINK1 gene knockdown.	scutellarin	36-39	cytochrome c, somatic	Homo sapiens	132-137
33485979-16	2021	Moreover, the beneficial effects of Scu on HG-induced low expression of Parkin, overproduction of ROS, and over expressions of P62, Cyt.c and Cleaved caspase-3 were weakened by PINK1 gene knockdown.	scutellarin	36-39	PTEN induced kinase 1	Homo sapiens	177-182
33981825-7	2021	Combination with scutellarin was able to inhibit the PKM2 activity and thus reduced the production of adenosine triphosphate (ATP) to sensitize the oxaliplatin-induced mitochondrial apoptosis pathway in both OR-SW480 and OR-HT29 cells.	scutellarin	17-28	pyruvate kinase M1/2	Homo sapiens	53-57
33549002-10	2021	Further study showed that Scu inhibited the activation of nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) and activated phospho-protein kinase B (p-AKT), nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase (HO-1).	scutellarin	26-29	NLR family, pyrin domain containing 3	Mus musculus	137-142
33549002-10	2021	Further study showed that Scu inhibited the activation of nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) and activated phospho-protein kinase B (p-AKT), nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase (HO-1).	scutellarin	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	148-170
33549002-10	2021	Further study showed that Scu inhibited the activation of nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) and activated phospho-protein kinase B (p-AKT), nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase (HO-1).	scutellarin	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	172-181
33549002-10	2021	Further study showed that Scu inhibited the activation of nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) and activated phospho-protein kinase B (p-AKT), nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase (HO-1).	scutellarin	26-29	thymoma viral proto-oncogene 1	Mus musculus	225-228
33549002-10	2021	Further study showed that Scu inhibited the activation of nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) and activated phospho-protein kinase B (p-AKT), nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase (HO-1).	scutellarin	26-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	231-265
33549002-10	2021	Further study showed that Scu inhibited the activation of nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) and activated phospho-protein kinase B (p-AKT), nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase (HO-1).	scutellarin	26-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	267-271
33549002-10	2021	Further study showed that Scu inhibited the activation of nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) and activated phospho-protein kinase B (p-AKT), nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase (HO-1).	scutellarin	26-29	heme oxygenase 1	Mus musculus	294-298
33704029-9	2021	Additionally, SCU treatment depressed the elevated levels of autophagy-related proteins and the p75 neurotrophin receptor (p75NTR) in both cortex and hippocampus.	scutellarin	14-17	nerve growth factor receptor	Rattus norvegicus	96-121
33704029-9	2021	Additionally, SCU treatment depressed the elevated levels of autophagy-related proteins and the p75 neurotrophin receptor (p75NTR) in both cortex and hippocampus.	scutellarin	14-17	nerve growth factor receptor	Rattus norvegicus	123-129
32781970-0	2021	Scutellarin Suppresses RPMI7951 Melanoma Cell Proliferation by Targeting TOPK.	scutellarin	0-11	PDZ binding kinase	Homo sapiens	73-77
33981825-8	2021	It was indicated that scutellarin resensitizes oxaliplatin-resistant CRC cells to oxaliplatin treatment through inhibition of PKM2.	scutellarin	22-33	pyruvate kinase M1/2	Homo sapiens	126-130
33433546-4	2021	In one set of experiments, the primary cultured mouse ovarian GCs were co-treated with ZEA and Scu for 24 h. The results showed that Scu significantly alleviated ZEA-induced cell damage, restored cell cycle arrest, and inhibited apoptosis by reducing the ratio of cleaved-caspase-3, cleaved-PARP, and Bax/Bcl-2.	scutellarin	133-136	poly (ADP-ribose) polymerase family, member 1	Mus musculus	291-295
33433546-4	2021	In one set of experiments, the primary cultured mouse ovarian GCs were co-treated with ZEA and Scu for 24 h. The results showed that Scu significantly alleviated ZEA-induced cell damage, restored cell cycle arrest, and inhibited apoptosis by reducing the ratio of cleaved-caspase-3, cleaved-PARP, and Bax/Bcl-2.	scutellarin	133-136	BCL2-associated X protein	Mus musculus	301-304
33433546-4	2021	In one set of experiments, the primary cultured mouse ovarian GCs were co-treated with ZEA and Scu for 24 h. The results showed that Scu significantly alleviated ZEA-induced cell damage, restored cell cycle arrest, and inhibited apoptosis by reducing the ratio of cleaved-caspase-3, cleaved-PARP, and Bax/Bcl-2.	scutellarin	133-136	B cell leukemia/lymphoma 2	Mus musculus	305-310
33532184-4	2021	Scutellarin dose-dependently inhibited intracellular LPS-induced release of caspase-11p26 (indicative of caspase-11 activation) and generation of N-terminal fragment of gasdermin D (GSDMD-NT), leading to reduced pyroptosis.	scutellarin	0-11	gasdermin D	Mus musculus	182-187
33532184-6	2021	Scutellarin also suppressed LPS-induced caspase-11 activation and pyroptosis in RAW 264.7 cells lacking ASC expression.	scutellarin	0-11	PYD and CARD domain containing	Mus musculus	104-107
30501535-3	2020	In this study, we investigated the effect of scutellarin on cytochrome P450 3A4 (CYP3A4) and CYP3A5 expression.	scutellarin	45-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	60-79
33307844-4	2020	The solubility test indicated that the solubilizing ability of SCU:epsilon-PL-CD was significantly improved compared with SCU:beta-CD and free SCU.	scutellarin	63-66	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	126-133
32447519-7	2021	Additionally, molecular docking simulation confifirmed that scutellarin exhibited a relatively high potential for binding to the active sites of NOS3 and F2.	scutellarin	60-71	nitric oxide synthase 3	Homo sapiens	145-149
33188176-4	2020	In this study, scutellarin suppressed BLM-induced inflammation via NF-kappaB/NLRP3 pathway both in vivo and in vitro.	scutellarin	15-26	NLR family pyrin domain containing 3	Homo sapiens	77-82
33182053-8	2020	Western blot analysis results showed that scutellarin pretreatment suppressed LPS-induced the protein levels of NLRP3, caspase-1, and IL-1beta.	scutellarin	42-53	NLR family, pyrin domain containing 3	Rattus norvegicus	112-117
33182053-8	2020	Western blot analysis results showed that scutellarin pretreatment suppressed LPS-induced the protein levels of NLRP3, caspase-1, and IL-1beta.	scutellarin	42-53	caspase 1	Rattus norvegicus	119-128
33182053-8	2020	Western blot analysis results showed that scutellarin pretreatment suppressed LPS-induced the protein levels of NLRP3, caspase-1, and IL-1beta.	scutellarin	42-53	interleukin 1 alpha	Rattus norvegicus	134-142
33182053-10	2020	These findings suggest that scutellarin effectively improves LPS-induced inflammation-related depressive-like behaviors by inhibiting LPS-induced neuroinflammation and microglia activation, possibly via regulation of the ROS/NLRP3 signaling pathway and microglia activation.	scutellarin	28-39	NLR family, pyrin domain containing 3	Rattus norvegicus	225-230
30501535-3	2020	In this study, we investigated the effect of scutellarin on cytochrome P450 3A4 (CYP3A4) and CYP3A5 expression.	scutellarin	45-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
30501535-3	2020	In this study, we investigated the effect of scutellarin on cytochrome P450 3A4 (CYP3A4) and CYP3A5 expression.	scutellarin	45-56	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	93-99
30501535-10	2020	Results showed that scutellarin significantly inhibited the CYP3A4 and CYP3A5 expression both in vitro and in vivo.	scutellarin	20-31	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	60-66
30501535-10	2020	Results showed that scutellarin significantly inhibited the CYP3A4 and CYP3A5 expression both in vitro and in vivo.	scutellarin	20-31	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	71-77
30501535-11	2020	However, the levels of hsa-miR-27a, hsa-miR-27b, hsa-miR-148a, hsa-miR-298 and hsa-miR-451a in scutellarin group did not show significant changes when compared with those of the placebo group (p > 0.05), suggesting that the expression of these miRNAs is not relevant to the scutellarin-induced down-regulation of CYP3A4 and CYP3A5.	scutellarin	95-106	microRNA 451a	Homo sapiens	79-91
33114041-6	2020	Furthermore, treatment with the PKCgamma inhibitor, scutellarin, rescued cerebellar LTD, with the phosphorylation of PKCalpha and the dissociation of GluR2 and GRIP.	scutellarin	52-63	protein kinase C, gamma	Mus musculus	32-40
33123800-5	2020	RESULTS: Scutellarin inhibited hOATP1B3- and rOATP1B2-mediated rosuvastatin uptake (IC50: 45.54 +- 6.67 muM and 27.58 +- 3.97 muM) in vitro in a concentration-dependent manner.	scutellarin	9-20	solute carrier organic anion transporter family member 1B3	Homo sapiens	31-39
33123800-9	2020	CONCLUSION: Scutellarin may inhibit the hOATP1B3- and rOATP1B2-mediated transport of rosuvastatin in vitro, and exerts a moderate inhibitory effect on the pharmacokinetics of rosuvastatin in rats.	scutellarin	12-23	solute carrier organic anion transporter family member 1B3	Homo sapiens	40-48
33114041-6	2020	Furthermore, treatment with the PKCgamma inhibitor, scutellarin, rescued cerebellar LTD, with the phosphorylation of PKCalpha and the dissociation of GluR2 and GRIP.	scutellarin	52-63	protein kinase C, alpha	Mus musculus	117-125
33114041-6	2020	Furthermore, treatment with the PKCgamma inhibitor, scutellarin, rescued cerebellar LTD, with the phosphorylation of PKCalpha and the dissociation of GluR2 and GRIP.	scutellarin	52-63	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	150-155
33114041-6	2020	Furthermore, treatment with the PKCgamma inhibitor, scutellarin, rescued cerebellar LTD, with the phosphorylation of PKCalpha and the dissociation of GluR2 and GRIP.	scutellarin	52-63	glutamate receptor interacting protein 1	Mus musculus	160-164
31792810-4	2020	Furthermore, expression of p-p38 along with that of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta(IL-1beta), and inducible nitric oxide synthase (iNOS) in LPS-activated microglia subjected to pretreatment with p38 inhibitor SB203580, p38 activator sc-201214, scutellarin, or a combination of them was evaluated.	scutellarin	273-284	mitogen activated protein kinase 14	Rattus norvegicus	29-32
33192525-10	2020	Importantly, knockdown of CCN1 not only aggravated NLRP3 inflammasome activation and apoptosis but also abrogated the protective effect of scutellarin in UA-induced HK-2 injury.	scutellarin	139-150	cyclin A2	Mus musculus	26-30
33192525-11	2020	Thus, scutellarin might alleviate HN progression via a mechanism involved in CCN1 regulation on NLRP3 inflammasome activation.	scutellarin	6-17	cyclin A2	Mus musculus	77-81
33192525-11	2020	Thus, scutellarin might alleviate HN progression via a mechanism involved in CCN1 regulation on NLRP3 inflammasome activation.	scutellarin	6-17	NLR family, pyrin domain containing 3	Mus musculus	96-101
32220026-0	2020	beta-Glucuronidase- and OATP2B1-mediated drug interaction of scutellarin in Dengzhan Xixin Injection: A formulation aspect.	scutellarin	61-72	glucuronidase, beta	Rattus norvegicus	0-18
31792810-4	2020	Furthermore, expression of p-p38 along with that of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta(IL-1beta), and inducible nitric oxide synthase (iNOS) in LPS-activated microglia subjected to pretreatment with p38 inhibitor SB203580, p38 activator sc-201214, scutellarin, or a combination of them was evaluated.	scutellarin	273-284	nitric oxide synthase 2	Rattus norvegicus	160-164
31792810-5	2020	FINDINGS: Scutellarin markedly attenuated the expression of p-p38, p-JNK in AM/BM in MCAO rats and in vitro.	scutellarin	10-21	mitogen activated protein kinase 14	Rattus norvegicus	62-65
31792810-6	2020	Conversely, p-ERK1/2 expression level was significantly increased by scutellarin.	scutellarin	69-80	mitogen activated protein kinase 3	Rattus norvegicus	14-20
31792810-7	2020	Meanwhile, scutellarin suppressed the expression of proinflammatory mediators including iNOS, TNF-alpha, and IL-1beta in AM/BM.	scutellarin	11-22	nitric oxide synthase 2	Rattus norvegicus	88-92
31792810-7	2020	Meanwhile, scutellarin suppressed the expression of proinflammatory mediators including iNOS, TNF-alpha, and IL-1beta in AM/BM.	scutellarin	11-22	tumor necrosis factor	Rattus norvegicus	94-103
31792810-7	2020	Meanwhile, scutellarin suppressed the expression of proinflammatory mediators including iNOS, TNF-alpha, and IL-1beta in AM/BM.	scutellarin	11-22	interleukin 1 beta	Rattus norvegicus	109-117
31792810-11	2020	CONCLUSIONS: The results suggest that scutellarin down-regulates the expression of proinflammatory mediators in AM/BM through suppressing the p-JNK and p-p38 MAPKs.	scutellarin	38-49	mitogen activated protein kinase 14	Rattus norvegicus	154-157
31792810-13	2020	Besides, p38 MAPKs activator reverses the effect of scutellarin.	scutellarin	52-63	mitogen activated protein kinase 14	Rattus norvegicus	9-12
31792810-14	2020	Additionally, scutellarin increases p-ERK1/2 expression that may be neuroprotective.	scutellarin	14-25	mitogen activated protein kinase 3	Rattus norvegicus	38-44
32283646-9	2020	In summary, our results reveal the interactive mechanism of SIRT6 and the inhibitors and we also provide Scutellarin as a new potential inhibitor of SIRT6.	scutellarin	105-116	sirtuin 6	Homo sapiens	60-65
31828866-0	2020	Scutellarin, a modulator of mTOR, attenuates hepatic insulin resistance by regulating hepatocyte lipid metabolism via SREBP-1c suppression.	scutellarin	0-11	mechanistic target of rapamycin kinase	Homo sapiens	28-32
31828866-0	2020	Scutellarin, a modulator of mTOR, attenuates hepatic insulin resistance by regulating hepatocyte lipid metabolism via SREBP-1c suppression.	scutellarin	0-11	insulin	Homo sapiens	53-60
31828866-0	2020	Scutellarin, a modulator of mTOR, attenuates hepatic insulin resistance by regulating hepatocyte lipid metabolism via SREBP-1c suppression.	scutellarin	0-11	sterol regulatory element binding transcription factor 1	Homo sapiens	118-126
31828866-5	2020	In vitro, we found that Scu decreased insulin-dependent lipid accumulation and the mRNA expression of CD36, Fasn, and ACC in PA-treated HepG2 cells.	scutellarin	24-27	insulin	Homo sapiens	38-45
31828866-6	2020	Additionally, Scu upregulated Akt phosphorylation and improved the insulin signalling pathway.	scutellarin	14-17	insulin	Homo sapiens	67-74
31828866-7	2020	Moreover, Scu downregulated mammalian target of rapamycin (mTOR) phosphorylation and the n-SREBP-1c protein level and also reduced lipid accumulation via the mTOR-dependent pathway, as confirmed by the molecular docking of Scu to mTOR.	scutellarin	10-13	mechanistic target of rapamycin kinase	Homo sapiens	28-57
31828866-7	2020	Moreover, Scu downregulated mammalian target of rapamycin (mTOR) phosphorylation and the n-SREBP-1c protein level and also reduced lipid accumulation via the mTOR-dependent pathway, as confirmed by the molecular docking of Scu to mTOR.	scutellarin	10-13	mechanistic target of rapamycin kinase	Homo sapiens	59-63
31828866-7	2020	Moreover, Scu downregulated mammalian target of rapamycin (mTOR) phosphorylation and the n-SREBP-1c protein level and also reduced lipid accumulation via the mTOR-dependent pathway, as confirmed by the molecular docking of Scu to mTOR.	scutellarin	10-13	sterol regulatory element binding transcription factor 1	Homo sapiens	91-99
31828866-7	2020	Moreover, Scu downregulated mammalian target of rapamycin (mTOR) phosphorylation and the n-SREBP-1c protein level and also reduced lipid accumulation via the mTOR-dependent pathway, as confirmed by the molecular docking of Scu to mTOR.	scutellarin	10-13	mechanistic target of rapamycin kinase	Homo sapiens	158-162
31828866-7	2020	Moreover, Scu downregulated mammalian target of rapamycin (mTOR) phosphorylation and the n-SREBP-1c protein level and also reduced lipid accumulation via the mTOR-dependent pathway, as confirmed by the molecular docking of Scu to mTOR.	scutellarin	10-13	mechanistic target of rapamycin kinase	Homo sapiens	158-162
31828866-9	2020	Moreover, Scu reduced hepatocyte steatosis, decreased lipid accumulation and triglyceride levels, inhibited mTOR phosphorylation, and decreased the SREBP-1c level in the liver.	scutellarin	10-13	mechanistic target of rapamycin kinase	Homo sapiens	108-112
31828866-9	2020	Moreover, Scu reduced hepatocyte steatosis, decreased lipid accumulation and triglyceride levels, inhibited mTOR phosphorylation, and decreased the SREBP-1c level in the liver.	scutellarin	10-13	sterol regulatory element binding transcription factor 1	Homo sapiens	148-156
31828866-10	2020	Taken together, these findings suggest that Scu ameliorates hepatic IR by regulating hepatocyte lipid metabolism via the mTOR-dependent pathway through SREBP-1c suppression.	scutellarin	44-47	mechanistic target of rapamycin kinase	Homo sapiens	121-125
31828866-10	2020	Taken together, these findings suggest that Scu ameliorates hepatic IR by regulating hepatocyte lipid metabolism via the mTOR-dependent pathway through SREBP-1c suppression.	scutellarin	44-47	sterol regulatory element binding transcription factor 1	Homo sapiens	152-160
32337233-6	2020	The RANKL inhibitor, scutellarin, inhibited these effects in PC3-hFOB1.19 cocultures.	scutellarin	21-32	TNF superfamily member 11	Homo sapiens	4-9
32489049-10	2020	The in vitro experiments showed that scutellarin inhibited the growth, transformation and differentiation of HT-29 CSC cells, significantly down-regulated the mRNA levels of Lgr5, c-Myc, CK20 and Nanog in HT-29 CSC cells as well as the protein expression levels of c-Myc, Gli1 and Lgr5 in HT-29 CSC cells.	scutellarin	37-48	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	174-178
32489049-10	2020	The in vitro experiments showed that scutellarin inhibited the growth, transformation and differentiation of HT-29 CSC cells, significantly down-regulated the mRNA levels of Lgr5, c-Myc, CK20 and Nanog in HT-29 CSC cells as well as the protein expression levels of c-Myc, Gli1 and Lgr5 in HT-29 CSC cells.	scutellarin	37-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	180-185
32489049-10	2020	The in vitro experiments showed that scutellarin inhibited the growth, transformation and differentiation of HT-29 CSC cells, significantly down-regulated the mRNA levels of Lgr5, c-Myc, CK20 and Nanog in HT-29 CSC cells as well as the protein expression levels of c-Myc, Gli1 and Lgr5 in HT-29 CSC cells.	scutellarin	37-48	keratin 20	Homo sapiens	187-191
32489049-10	2020	The in vitro experiments showed that scutellarin inhibited the growth, transformation and differentiation of HT-29 CSC cells, significantly down-regulated the mRNA levels of Lgr5, c-Myc, CK20 and Nanog in HT-29 CSC cells as well as the protein expression levels of c-Myc, Gli1 and Lgr5 in HT-29 CSC cells.	scutellarin	37-48	Nanog homeobox	Homo sapiens	196-201
32489049-10	2020	The in vitro experiments showed that scutellarin inhibited the growth, transformation and differentiation of HT-29 CSC cells, significantly down-regulated the mRNA levels of Lgr5, c-Myc, CK20 and Nanog in HT-29 CSC cells as well as the protein expression levels of c-Myc, Gli1 and Lgr5 in HT-29 CSC cells.	scutellarin	37-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	265-270
32489049-10	2020	The in vitro experiments showed that scutellarin inhibited the growth, transformation and differentiation of HT-29 CSC cells, significantly down-regulated the mRNA levels of Lgr5, c-Myc, CK20 and Nanog in HT-29 CSC cells as well as the protein expression levels of c-Myc, Gli1 and Lgr5 in HT-29 CSC cells.	scutellarin	37-48	GLI family zinc finger 1	Homo sapiens	272-276
32226478-4	2020	The apoptosis of HCT-116 and RKO cells after Scutellarin administration was determined by TUNEL staining and Caspase 3/7 activity.	scutellarin	45-56	caspase 3	Homo sapiens	109-118
32283646-9	2020	In summary, our results reveal the interactive mechanism of SIRT6 and the inhibitors and we also provide Scutellarin as a new potential inhibitor of SIRT6.	scutellarin	105-116	sirtuin 6	Homo sapiens	149-154
31554627-0	2019	Scutellarin suppresses patient-derived xenograft tumor growth by directly targeting AKT in esophageal squamous cell carcinoma.	scutellarin	0-11	AKT serine/threonine kinase 1	Homo sapiens	84-87
31810113-0	2020	Dengzhan Shengmai capsules and their active component scutellarin prevent cognitive decline in APP/PS1 mice by accelerating Abeta aggregation and reducing oligomers formation.	scutellarin	54-65	presenilin 1	Mus musculus	99-102
31810113-6	2020	In vitro, we confirmed scutellarin"s role in accelerating transforming Abeta42 monomers into high-molecular-mass aggregates by biochemical assays, which supported the results observed in drug-treated APP/PS1 mice.	scutellarin	23-34	amyloid beta (A4) precursor protein	Mus musculus	200-207
32489049-10	2020	The in vitro experiments showed that scutellarin inhibited the growth, transformation and differentiation of HT-29 CSC cells, significantly down-regulated the mRNA levels of Lgr5, c-Myc, CK20 and Nanog in HT-29 CSC cells as well as the protein expression levels of c-Myc, Gli1 and Lgr5 in HT-29 CSC cells.	scutellarin	37-48	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	281-285
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	prominin 1	Mus musculus	176-181
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	183-187
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	GLI-Kruppel family member GLI1	Mus musculus	189-193
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	patched 1	Mus musculus	195-200
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	202-207
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	antigen identified by monoclonal antibody Ki 67	Mus musculus	209-214
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	keratin 20	Mus musculus	216-220
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	Nanog homeobox	Mus musculus	225-230
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	264-269
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	GLI-Kruppel family member GLI1	Mus musculus	271-275
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	277-281
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	prominin 1	Mus musculus	283-288
32489049-11	2020	Additionally, animal experiments showed that scutellarin significantly inhibited the growth of subcutaneous xenografts in nude mice, and down-regulated the mRNA expressions of CD133, Lgr5, Gli1, Ptch1, c-Myc, Ki-67, CK20 and Nanog as well as the protein levels of c-Myc, Gli1, Lgr5, CD133 and Ki-67 of xenografts in nude mice.	scutellarin	45-56	antigen identified by monoclonal antibody Ki 67	Mus musculus	293-298
32521905-0	2020	Scutellarin exerts anticancer effects on human leukemia cells via induction of Sub-G1 cell cycle arrest, apoptosis and also inhibits migration and invasion by targeting Raf/MEK/ERK signalling pathway.	scutellarin	0-11	mitogen-activated protein kinase kinase 7	Homo sapiens	173-176
32521905-0	2020	Scutellarin exerts anticancer effects on human leukemia cells via induction of Sub-G1 cell cycle arrest, apoptosis and also inhibits migration and invasion by targeting Raf/MEK/ERK signalling pathway.	scutellarin	0-11	mitogen-activated protein kinase 1	Homo sapiens	177-180
32521905-7	2020	Further, scutellarin was shown to induce apoptosis which was initially exhibited by DAPI and annexin-V/propidium iodide (PI) staining and then confirmed by western blot in which it was shown to trigger regulation of Bax and downregulation of Bcl-2 in K562 human leukemia cells.	scutellarin	9-20	annexin A5	Homo sapiens	93-102
32521905-7	2020	Further, scutellarin was shown to induce apoptosis which was initially exhibited by DAPI and annexin-V/propidium iodide (PI) staining and then confirmed by western blot in which it was shown to trigger regulation of Bax and downregulation of Bcl-2 in K562 human leukemia cells.	scutellarin	9-20	BCL2 associated X, apoptosis regulator	Homo sapiens	216-219
32521905-7	2020	Further, scutellarin was shown to induce apoptosis which was initially exhibited by DAPI and annexin-V/propidium iodide (PI) staining and then confirmed by western blot in which it was shown to trigger regulation of Bax and downregulation of Bcl-2 in K562 human leukemia cells.	scutellarin	9-20	BCL2 apoptosis regulator	Homo sapiens	242-247
32521905-10	2020	CONCLUSION: In conclusion, scutellarin could inhibit the growth of K562 human leukemia cells by inducing apoptosis, cell cycle arrest, inhibition of cell migration and invasion and downregulating the expressions of p-Raf, p-MEK1/2 and p-ERK1/2.	scutellarin	27-38	mitogen-activated protein kinase kinase 1	Homo sapiens	224-230
32521905-10	2020	CONCLUSION: In conclusion, scutellarin could inhibit the growth of K562 human leukemia cells by inducing apoptosis, cell cycle arrest, inhibition of cell migration and invasion and downregulating the expressions of p-Raf, p-MEK1/2 and p-ERK1/2.	scutellarin	27-38	mitogen-activated protein kinase 3	Homo sapiens	237-243
31999976-0	2020	Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation.	scutellarin	0-11	NLR family, pyrin domain containing 3	Rattus norvegicus	83-88
31999976-3	2020	Whether Scu has any influence on the activation of NLRP3 inflammasome in cardiomyocytes remains unknown.	scutellarin	8-11	NLR family, pyrin domain containing 3	Rattus norvegicus	51-56
31999976-4	2020	PURPOSE: We aimed to examine the therapeutic effect of Scu on cardiomyocyte ischemia-reperfusion (I/R) injury and its effect on NLRP3 inflammasome in rats with acute myocardial I/R injury and anoxia/reoxygenation (A/R)-induced H9c2 injuries.	scutellarin	55-58	NLR family, pyrin domain containing 3	Rattus norvegicus	128-133
31999976-13	2020	Scu reduced NLRP3 inflammasome activation, inhibited mTORC1 activity, and increased Akt phosphorylation.	scutellarin	0-3	NLR family, pyrin domain containing 3	Rattus norvegicus	12-17
31999976-13	2020	Scu reduced NLRP3 inflammasome activation, inhibited mTORC1 activity, and increased Akt phosphorylation.	scutellarin	0-3	CREB regulated transcription coactivator 1	Mus musculus	53-59
31999976-15	2020	The Scu-mediated NLRP3 inflammasome and mTORC1 inhibition and cardioprotection were abolished through the genetic silencing of Akt by siRNA.	scutellarin	4-7	NLR family, pyrin domain containing 3	Rattus norvegicus	17-22
31999976-15	2020	The Scu-mediated NLRP3 inflammasome and mTORC1 inhibition and cardioprotection were abolished through the genetic silencing of Akt by siRNA.	scutellarin	4-7	CREB regulated transcription coactivator 1	Mus musculus	40-46
31999976-18	2020	In addition, inflammasome restriction by Scu was dependent on Akt activation and mTORC1 inhibition.	scutellarin	41-44	CREB regulated transcription coactivator 1	Mus musculus	81-87
31939603-3	2020	Here, using an array of biophysical tools combined with cellular assays, we demonstrate that the novel polyphenolic compound scutellarin efficiently inhibits the uninduced and metal-induced fibrillation of alpha-Syn by acting at the nucleation stage and stabilizes a partially folded intermediate of alpha-Syn to form SDS-resistant, higher-order oligomers (~680 kDa) and also disaggregates preformed fibrils of alpha-Syn into similar type of higher-order oligomers.	scutellarin	125-136	synemin	Homo sapiens	212-215
31939603-3	2020	Here, using an array of biophysical tools combined with cellular assays, we demonstrate that the novel polyphenolic compound scutellarin efficiently inhibits the uninduced and metal-induced fibrillation of alpha-Syn by acting at the nucleation stage and stabilizes a partially folded intermediate of alpha-Syn to form SDS-resistant, higher-order oligomers (~680 kDa) and also disaggregates preformed fibrils of alpha-Syn into similar type of higher-order oligomers.	scutellarin	125-136	synuclein alpha	Homo sapiens	206-215
31939603-3	2020	Here, using an array of biophysical tools combined with cellular assays, we demonstrate that the novel polyphenolic compound scutellarin efficiently inhibits the uninduced and metal-induced fibrillation of alpha-Syn by acting at the nucleation stage and stabilizes a partially folded intermediate of alpha-Syn to form SDS-resistant, higher-order oligomers (~680 kDa) and also disaggregates preformed fibrils of alpha-Syn into similar type of higher-order oligomers.	scutellarin	125-136	synuclein alpha	Homo sapiens	300-309
31939603-4	2020	ANS binding assay, fluorescence lifetime measurements and cell-toxicity experiments reveal scutellarin-generated oligomers as compact, low hydrophobicity structures with modulated surface properties and significantly reduced cytotoxicity than the fibrillation intermediates of alpha-Syn control.	scutellarin	91-102	synuclein alpha	Homo sapiens	277-286
31939603-6	2020	Molecular docking approaches suggest binding of scutellarin to the residues present in the NAC region and C-terminus of monomeric alpha-Syn and the C-terminal residues of fibrillar alpha-Syn, demonstrating inhibition of fibrillation upon binding to these residues and possible stabilization of the autoinhibitory conformation of alpha-Syn.	scutellarin	48-59	synuclein alpha	Homo sapiens	130-139
31939603-6	2020	Molecular docking approaches suggest binding of scutellarin to the residues present in the NAC region and C-terminus of monomeric alpha-Syn and the C-terminal residues of fibrillar alpha-Syn, demonstrating inhibition of fibrillation upon binding to these residues and possible stabilization of the autoinhibitory conformation of alpha-Syn.	scutellarin	48-59	synuclein alpha	Homo sapiens	181-190
31939603-6	2020	Molecular docking approaches suggest binding of scutellarin to the residues present in the NAC region and C-terminus of monomeric alpha-Syn and the C-terminal residues of fibrillar alpha-Syn, demonstrating inhibition of fibrillation upon binding to these residues and possible stabilization of the autoinhibitory conformation of alpha-Syn.	scutellarin	48-59	synuclein alpha	Homo sapiens	181-190
31757676-0	2020	Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/beta-catenin and MAPK signaling pathways.	scutellarin	0-11	catenin (cadherin associated protein), beta 1	Mus musculus	87-99
31757676-4	2020	Scutellarin downregulate the mRNA and protein expression of MMP1, MMP13, and ADAMTS-5, Wnt3a, Frizzled7 and promote the expression of Collagen II and Aggrecan.	scutellarin	0-11	matrix metallopeptidase 13	Mus musculus	60-64
31757676-4	2020	Scutellarin downregulate the mRNA and protein expression of MMP1, MMP13, and ADAMTS-5, Wnt3a, Frizzled7 and promote the expression of Collagen II and Aggrecan.	scutellarin	0-11	matrix metallopeptidase 13	Mus musculus	66-71
31757676-4	2020	Scutellarin downregulate the mRNA and protein expression of MMP1, MMP13, and ADAMTS-5, Wnt3a, Frizzled7 and promote the expression of Collagen II and Aggrecan.	scutellarin	0-11	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	77-85
31757676-4	2020	Scutellarin downregulate the mRNA and protein expression of MMP1, MMP13, and ADAMTS-5, Wnt3a, Frizzled7 and promote the expression of Collagen II and Aggrecan.	scutellarin	0-11	wingless-type MMTV integration site family, member 3A	Mus musculus	87-92
31757676-4	2020	Scutellarin downregulate the mRNA and protein expression of MMP1, MMP13, and ADAMTS-5, Wnt3a, Frizzled7 and promote the expression of Collagen II and Aggrecan.	scutellarin	0-11	frizzled class receptor 7	Mus musculus	94-103
31757676-5	2020	Moreover, scutellarin inhibit the migration of beta-catenin and phosphorylation of p38 into the nucleus, which may relate to the mediation of the Wnt/beta-catenin and MAPK signaling pathway.	scutellarin	10-21	catenin (cadherin associated protein), beta 1	Mus musculus	47-59
31757676-5	2020	Moreover, scutellarin inhibit the migration of beta-catenin and phosphorylation of p38 into the nucleus, which may relate to the mediation of the Wnt/beta-catenin and MAPK signaling pathway.	scutellarin	10-21	mitogen-activated protein kinase 14	Mus musculus	83-86
31757676-5	2020	Moreover, scutellarin inhibit the migration of beta-catenin and phosphorylation of p38 into the nucleus, which may relate to the mediation of the Wnt/beta-catenin and MAPK signaling pathway.	scutellarin	10-21	catenin (cadherin associated protein), beta 1	Mus musculus	150-162
31976335-10	2019	Conclusions: These results suggested that SCU can be an oral drug to alleviate microvascular dysfunction of DR and exerts its antiangiogenic effects by inhibiting the expression of the crosstalk of VEGF, p-ERK, p-FAK, and p-Src.	scutellarin	42-45	vascular endothelial growth factor A	Rattus norvegicus	198-202
31976335-10	2019	Conclusions: These results suggested that SCU can be an oral drug to alleviate microvascular dysfunction of DR and exerts its antiangiogenic effects by inhibiting the expression of the crosstalk of VEGF, p-ERK, p-FAK, and p-Src.	scutellarin	42-45	Eph receptor B1	Rattus norvegicus	206-209
31976335-10	2019	Conclusions: These results suggested that SCU can be an oral drug to alleviate microvascular dysfunction of DR and exerts its antiangiogenic effects by inhibiting the expression of the crosstalk of VEGF, p-ERK, p-FAK, and p-Src.	scutellarin	42-45	protein tyrosine kinase 2	Rattus norvegicus	213-216
31976335-10	2019	Conclusions: These results suggested that SCU can be an oral drug to alleviate microvascular dysfunction of DR and exerts its antiangiogenic effects by inhibiting the expression of the crosstalk of VEGF, p-ERK, p-FAK, and p-Src.	scutellarin	42-45	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	224-227
31554627-4	2019	In the present study, we report that scutellarin is a potential AKT inhibitor that suppresses patient-derived xenograft ESCC tumor growth.	scutellarin	37-48	AKT serine/threonine kinase 1	Homo sapiens	64-67
31554627-6	2019	We found that scutellarin directly binds to the AKT1/2 proteins and inhibits activities of AKT1/2 in vitro.	scutellarin	14-25	AKT serine/threonine kinase 1	Homo sapiens	48-54
31554627-6	2019	We found that scutellarin directly binds to the AKT1/2 proteins and inhibits activities of AKT1/2 in vitro.	scutellarin	14-25	AKT serine/threonine kinase 1	Homo sapiens	91-97
31554627-9	2019	The inhibition of cell growth by scutellarin is dependent on the expression of the AKT protein.	scutellarin	33-44	AKT serine/threonine kinase 1	Homo sapiens	83-86
31554627-11	2019	Taken together, our data suggest that scutellarin is a novel AKT inhibitor that may prevent progression of ESCC.	scutellarin	38-49	AKT serine/threonine kinase 1	Homo sapiens	61-64
30891776-0	2019	Scutellarin exerts protective effects against atherosclerosis in rats by regulating the Hippo-FOXO3A and PI3K/AKT signaling pathways.	scutellarin	0-11	forkhead box O3	Rattus norvegicus	94-100
31711940-6	2019	We found that the inflammatory response stimulated by TNF-alpha was significantly inhibited by the addition of scutellarin.	scutellarin	111-122	tumor necrosis factor	Mus musculus	54-63
31654068-0	2019	Scutellarin attenuates hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1/Nrf2/ARE signaling.	scutellarin	0-11	kelch like ECH associated protein 1	Homo sapiens	131-136
31654068-0	2019	Scutellarin attenuates hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1/Nrf2/ARE signaling.	scutellarin	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
31654068-7	2019	Moreover, scutellarin significantly upregulated bcl-2 expression and downregulated bax expression in hepatocytes exposed to H/R.	scutellarin	10-21	BCL2 apoptosis regulator	Homo sapiens	48-53
31654068-7	2019	Moreover, scutellarin significantly upregulated bcl-2 expression and downregulated bax expression in hepatocytes exposed to H/R.	scutellarin	10-21	BCL2 associated X, apoptosis regulator	Homo sapiens	83-86
31654068-8	2019	Furthermore, scutellarin treatment caused significant decrease in Keap1 expression and increase in nuclear Nrf2 expression.	scutellarin	13-24	kelch like ECH associated protein 1	Homo sapiens	66-71
31654068-8	2019	Furthermore, scutellarin treatment caused significant decrease in Keap1 expression and increase in nuclear Nrf2 expression.	scutellarin	13-24	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
31654068-9	2019	Besides, scutellarin induced the mRNA expressions of heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1).	scutellarin	9-20	heme oxygenase 1	Homo sapiens	53-69
31654068-9	2019	Besides, scutellarin induced the mRNA expressions of heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1).	scutellarin	9-20	NAD(P)H quinone dehydrogenase 1	Homo sapiens	81-114
31654068-9	2019	Besides, scutellarin induced the mRNA expressions of heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1).	scutellarin	9-20	NAD(P)H quinone dehydrogenase 1	Homo sapiens	116-120
31654068-10	2019	Inhibition of Nrf2 significantly reversed the protective effects of scutellarin on H/R-stimulated hepatocytes.	scutellarin	68-79	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
31654068-11	2019	In conclusion, these findings demonstrated that scutellarin protected hepatocytes from H/R-induced oxidative injury through regulating the Keap1/Nrf2/ARE signaling pathway, indicating a potential relevance of scutellarin in attenuating hepatic I/R injury.	scutellarin	48-59	kelch like ECH associated protein 1	Homo sapiens	139-144
31654068-11	2019	In conclusion, these findings demonstrated that scutellarin protected hepatocytes from H/R-induced oxidative injury through regulating the Keap1/Nrf2/ARE signaling pathway, indicating a potential relevance of scutellarin in attenuating hepatic I/R injury.	scutellarin	48-59	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
31654068-11	2019	In conclusion, these findings demonstrated that scutellarin protected hepatocytes from H/R-induced oxidative injury through regulating the Keap1/Nrf2/ARE signaling pathway, indicating a potential relevance of scutellarin in attenuating hepatic I/R injury.	scutellarin	209-220	kelch like ECH associated protein 1	Homo sapiens	139-144
31654068-11	2019	In conclusion, these findings demonstrated that scutellarin protected hepatocytes from H/R-induced oxidative injury through regulating the Keap1/Nrf2/ARE signaling pathway, indicating a potential relevance of scutellarin in attenuating hepatic I/R injury.	scutellarin	209-220	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
30891776-0	2019	Scutellarin exerts protective effects against atherosclerosis in rats by regulating the Hippo-FOXO3A and PI3K/AKT signaling pathways.	scutellarin	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	110-113
30891776-3	2019	In this study, we aimed to investigate the anti-AS effects of scutellarin is related to controlling the Hippo-FOXO3A and PI3K/AKT signal pathway.	scutellarin	62-73	forkhead box O3	Rattus norvegicus	110-116
30891776-3	2019	In this study, we aimed to investigate the anti-AS effects of scutellarin is related to controlling the Hippo-FOXO3A and PI3K/AKT signal pathway.	scutellarin	62-73	AKT serine/threonine kinase 1	Rattus norvegicus	126-129
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	Bcl2-like 11	Rattus norvegicus	34-74
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	Bcl2-like 11	Rattus norvegicus	76-79
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	caspase 3	Rattus norvegicus	82-91
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	BCL2 associated X, apoptosis regulator	Rattus norvegicus	116-119
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	BCL2 associated X, apoptosis regulator	Rattus norvegicus	121-139
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	BCL2 associated X, apoptosis regulator	Rattus norvegicus	141-144
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	BCL2, apoptosis regulator	Rattus norvegicus	34-39
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	BCL2, apoptosis regulator	Rattus norvegicus	174-191
30891776-9	2019	Scutellarin significantly reduced Bcl-2 interacting mediator of cell death (Bim), caspase-3, APO-1, CD95 (Fas), and Bax: Bcl-2-associated X (Bax) levels and activated Bcl-2: B-cell lymphoma-2 (Bcl-2).	scutellarin	0-11	BCL2, apoptosis regulator	Rattus norvegicus	121-126
30891776-11	2019	When Mst1 was overexpressed or phosphoinositide 3-kinases suppressed, the effects of scutellarin were significantly blocked.	scutellarin	85-96	macrophage stimulating 1	Homo sapiens	5-9
30891776-12	2019	In conclusion, the results of the present study suggest that scutellarin exerts protective effects against AS by inhibiting endothelial cell injury and apoptosis by regulating the Hippo-FOXO3A and PI3K/AKT signal pathways.	scutellarin	61-72	forkhead box O3	Homo sapiens	186-192
30891776-12	2019	In conclusion, the results of the present study suggest that scutellarin exerts protective effects against AS by inhibiting endothelial cell injury and apoptosis by regulating the Hippo-FOXO3A and PI3K/AKT signal pathways.	scutellarin	61-72	AKT serine/threonine kinase 1	Homo sapiens	202-205
31258635-0	2019	Scutellarin-treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells.	scutellarin	0-11	claudin 5	Rattus norvegicus	38-47
31258635-0	2019	Scutellarin-treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells.	scutellarin	0-11	occludin	Rattus norvegicus	49-57
31258635-0	2019	Scutellarin-treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells.	scutellarin	0-11	tight junction protein 1	Rattus norvegicus	62-65
30797149-7	2019	Similarly, scutellarin administration inhibited apoptosis triggered by cisplatin through reducing the expressions of Cleaved caspase-3, Cleaved PARP, p53, and the ratio of Bax/Bcl-2.	scutellarin	11-22	poly (ADP-ribose) polymerase family, member 1	Mus musculus	144-148
30797149-7	2019	Similarly, scutellarin administration inhibited apoptosis triggered by cisplatin through reducing the expressions of Cleaved caspase-3, Cleaved PARP, p53, and the ratio of Bax/Bcl-2.	scutellarin	11-22	transformation related protein 53, pseudogene	Mus musculus	150-153
30797149-7	2019	Similarly, scutellarin administration inhibited apoptosis triggered by cisplatin through reducing the expressions of Cleaved caspase-3, Cleaved PARP, p53, and the ratio of Bax/Bcl-2.	scutellarin	11-22	BCL2-associated X protein	Mus musculus	172-175
30797149-7	2019	Similarly, scutellarin administration inhibited apoptosis triggered by cisplatin through reducing the expressions of Cleaved caspase-3, Cleaved PARP, p53, and the ratio of Bax/Bcl-2.	scutellarin	11-22	B cell leukemia/lymphoma 2	Mus musculus	176-181
30797149-8	2019	Moreover, scutellarin prevented cisplatin-induced inhibition of autophagy via enhancing LC3-II/LC3-I and Atg7, and inhibition of p62.	scutellarin	10-21	autophagy related 7	Mus musculus	105-109
30797149-8	2019	Moreover, scutellarin prevented cisplatin-induced inhibition of autophagy via enhancing LC3-II/LC3-I and Atg7, and inhibition of p62.	scutellarin	10-21	nucleoporin 62	Mus musculus	129-132
30797149-9	2019	Of note, the activations of JNK, ERK, p38 and stat3 induced by cisplatin were strikingly attenuated in scutellarin-treated mice.	scutellarin	103-114	mitogen-activated protein kinase 8	Mus musculus	28-31
30797149-9	2019	Of note, the activations of JNK, ERK, p38 and stat3 induced by cisplatin were strikingly attenuated in scutellarin-treated mice.	scutellarin	103-114	mitogen-activated protein kinase 14	Mus musculus	38-41
30797149-9	2019	Of note, the activations of JNK, ERK, p38 and stat3 induced by cisplatin were strikingly attenuated in scutellarin-treated mice.	scutellarin	103-114	signal transducer and activator of transcription 3	Mus musculus	46-51
30257368-3	2018	METHODS AND MATERIALS: RCC cell lines ACHN and 786-O were treated with different concentrations (0-210 muM) of Scutellarin in vitro.	scutellarin	111-122	latexin	Homo sapiens	103-106
30915356-0	2019	C18H17NO6 and Its Combination with Scutellarin Suppress the Proliferation and Induce the Apoptosis of Human Glioma Cells via Upregulation of Fas-Associated Factor 1 Expression.	scutellarin	35-46	Fas associated factor 1	Homo sapiens	141-164
30915356-20	2019	Conclusion: C18H17NO6 could efficiently suppress cell proliferation and induce cell apoptosis in glioma cells, and its combination with Scutellarin had a promoting effect, in which the underlying mechanism referred to the upregulation of Fas-associated factor 1.	scutellarin	136-147	Fas associated factor 1	Homo sapiens	238-261
30881587-0	2019	Scutellarin Exerts Hypoglycemic and Renal Protective Effects in db/db Mice via the Nrf2/HO-1 Signaling Pathway.	scutellarin	0-11	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
30881587-0	2019	Scutellarin Exerts Hypoglycemic and Renal Protective Effects in db/db Mice via the Nrf2/HO-1 Signaling Pathway.	scutellarin	0-11	heme oxygenase 1	Mus musculus	88-92
30503360-5	2019	Here, we found that the combination treatment of scutellarin and cisplatin enhanced apoptosis in ovarian cancer cells via increasing the extent of platinum-DNA adducts and the ratio of Bax/Bcl-2.	scutellarin	49-60	BCL2 associated X, apoptosis regulator	Homo sapiens	185-188
30503360-5	2019	Here, we found that the combination treatment of scutellarin and cisplatin enhanced apoptosis in ovarian cancer cells via increasing the extent of platinum-DNA adducts and the ratio of Bax/Bcl-2.	scutellarin	49-60	BCL2 apoptosis regulator	Homo sapiens	189-194
29936266-5	2018	Knockdown of CXCR4 reversed the scutellarin-induced increases in cell proliferation, ALP activity, and calcium deposition.	scutellarin	32-43	C-X-C motif chemokine receptor 4	Homo sapiens	13-18
29936266-5	2018	Knockdown of CXCR4 reversed the scutellarin-induced increases in cell proliferation, ALP activity, and calcium deposition.	scutellarin	32-43	alkaline phosphatase, placental	Homo sapiens	85-88
29936266-8	2018	A p65 inhibitor blocked scutellarin-induced increases in osteoblast proliferation and function.	scutellarin	24-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	2-5
30680088-10	2019	Scutellarin alleviated the H2O2-induced oxidative stress in ARPE-19 cells, which was illustrated by reduced levels of ROS and MDA, accompanied by increased SOD activity and GSH level.	scutellarin	0-11	superoxide dismutase 1	Homo sapiens	156-159
30680088-12	2019	H2O2 treatment resulted in significant increase in bax expression and decrease in bcl-2 expression, while the changes in the expressions of bax and bcl-2 were reversed by scutellarin treatment.	scutellarin	171-182	BCL2 associated X, apoptosis regulator	Homo sapiens	140-143
30680088-12	2019	H2O2 treatment resulted in significant increase in bax expression and decrease in bcl-2 expression, while the changes in the expressions of bax and bcl-2 were reversed by scutellarin treatment.	scutellarin	171-182	BCL2 apoptosis regulator	Homo sapiens	148-153
30680088-13	2019	In addition, scutellarin promoted the activation of JAK2/STAT3 signaling pathway in H2O2-induced ARPE-19 cells.	scutellarin	13-24	Janus kinase 2	Homo sapiens	52-56
30680088-13	2019	In addition, scutellarin promoted the activation of JAK2/STAT3 signaling pathway in H2O2-induced ARPE-19 cells.	scutellarin	13-24	signal transducer and activator of transcription 3	Homo sapiens	57-62
30680088-14	2019	Suppression of JAK2/STAT3 signaling pathway abolished the protective effects of scutellarin on H2O2-induced ARPE-19 cells.	scutellarin	80-91	Janus kinase 2	Homo sapiens	15-19
30680088-14	2019	Suppression of JAK2/STAT3 signaling pathway abolished the protective effects of scutellarin on H2O2-induced ARPE-19 cells.	scutellarin	80-91	signal transducer and activator of transcription 3	Homo sapiens	20-25
30680088-15	2019	Conclusion: These findings suggested that scutellarin was capable for alleviating H2O2-induced oxidative damage in ARPE-19 cells, which might be ascribed to the activation of JAK2/STAT3 signaling pathway.	scutellarin	42-53	Janus kinase 2	Homo sapiens	175-179
30680088-15	2019	Conclusion: These findings suggested that scutellarin was capable for alleviating H2O2-induced oxidative damage in ARPE-19 cells, which might be ascribed to the activation of JAK2/STAT3 signaling pathway.	scutellarin	42-53	signal transducer and activator of transcription 3	Homo sapiens	180-185
30257368-10	2018	Treatment of RCC cells with Scutellarin (30, 60, and 90 muM) markedly induced apoptosis and cell cycle arrested at G0/G1 phase in a concentration-dependent characteristic.	scutellarin	28-39	latexin	Homo sapiens	56-59
30257368-16	2018	CONCLUSION: Scutellarin inhibited RCC cell proliferation and invasion partially by enhancing the expression of PTEN through inhibition of P13K/AKT/mTOR pathway, suggesting that Scutellarin might serve as a potential therapeutic agent in RCC treatment.	scutellarin	12-23	phosphatase and tensin homolog	Homo sapiens	111-115
30257368-16	2018	CONCLUSION: Scutellarin inhibited RCC cell proliferation and invasion partially by enhancing the expression of PTEN through inhibition of P13K/AKT/mTOR pathway, suggesting that Scutellarin might serve as a potential therapeutic agent in RCC treatment.	scutellarin	12-23	AKT serine/threonine kinase 1	Homo sapiens	143-146
30257368-16	2018	CONCLUSION: Scutellarin inhibited RCC cell proliferation and invasion partially by enhancing the expression of PTEN through inhibition of P13K/AKT/mTOR pathway, suggesting that Scutellarin might serve as a potential therapeutic agent in RCC treatment.	scutellarin	12-23	mechanistic target of rapamycin kinase	Homo sapiens	147-151
29680917-0	2018	Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-kappaB and p38/JNK pathway in LPS-induced BV-2 microglial cells.	scutellarin	0-11	thymoma viral proto-oncogene 1	Mus musculus	67-70
30271483-0	2018	Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo.	scutellarin	0-11	mitogen-activated protein kinase 3	Mus musculus	67-73
30271483-0	2018	Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo.	scutellarin	0-11	thymoma viral proto-oncogene 1	Mus musculus	78-81
30271483-6	2018	Further study demonstrated that scutellarin stimulated phosphorylation of ERK1/2, and inhibition of ERK1/2 with inhibitor U0126 markedly attenuated scutellarin-induced autophagy.	scutellarin	32-43	mitogen-activated protein kinase 3	Mus musculus	74-80
30271483-6	2018	Further study demonstrated that scutellarin stimulated phosphorylation of ERK1/2, and inhibition of ERK1/2 with inhibitor U0126 markedly attenuated scutellarin-induced autophagy.	scutellarin	148-159	mitogen-activated protein kinase 3	Mus musculus	100-106
30106052-3	2018	The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity.	scutellarin	24-35	cytochrome b-245 beta chain	Rattus norvegicus	40-93
30106052-3	2018	The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity.	scutellarin	24-35	cytochrome b-245 beta chain	Rattus norvegicus	95-99
30106052-3	2018	The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity.	scutellarin	24-35	cytochrome b-245 beta chain	Rattus norvegicus	193-197
30106052-3	2018	The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity.	scutellarin	160-171	cytochrome b-245 beta chain	Rattus norvegicus	40-93
30106052-3	2018	The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity.	scutellarin	160-171	cytochrome b-245 beta chain	Rattus norvegicus	95-99
30106052-3	2018	The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity.	scutellarin	160-171	cytochrome b-245 beta chain	Rattus norvegicus	193-197
30106052-9	2018	Pretreatment with 10 or 50 muM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion.	scutellarin	31-42	cytochrome b-245 beta chain	Rattus norvegicus	104-108
30106052-9	2018	Pretreatment with 10 or 50 muM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion.	scutellarin	31-42	caspase 3	Rattus norvegicus	113-122
30106052-9	2018	Pretreatment with 10 or 50 muM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion.	scutellarin	31-42	gap junction protein, alpha 1	Rattus norvegicus	152-163
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	interleukin 6	Mus musculus	97-101
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	nitric oxide synthase 2, inducible	Mus musculus	107-111
29680917-5	2018	Consistent with the inhibition of NF-kappaB, scutellarin inhibited the phosphorylation of p38, JNK, and AKT without affecting phosphorylation of ERK1/2 or PI3K in LPS-induced BV-2 cells.	scutellarin	45-56	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-43
29680917-5	2018	Consistent with the inhibition of NF-kappaB, scutellarin inhibited the phosphorylation of p38, JNK, and AKT without affecting phosphorylation of ERK1/2 or PI3K in LPS-induced BV-2 cells.	scutellarin	45-56	mitogen-activated protein kinase 14	Mus musculus	90-93
29680917-5	2018	Consistent with the inhibition of NF-kappaB, scutellarin inhibited the phosphorylation of p38, JNK, and AKT without affecting phosphorylation of ERK1/2 or PI3K in LPS-induced BV-2 cells.	scutellarin	45-56	mitogen-activated protein kinase 8	Mus musculus	95-98
29680917-5	2018	Consistent with the inhibition of NF-kappaB, scutellarin inhibited the phosphorylation of p38, JNK, and AKT without affecting phosphorylation of ERK1/2 or PI3K in LPS-induced BV-2 cells.	scutellarin	45-56	thymoma viral proto-oncogene 1	Mus musculus	104-107
29680917-6	2018	Overall, the present study suggests that scutellarin inhibits the production of pro-inflammatory mediators via inhibition of the IKK-dependent NF-kappaB and p38/JNK signaling pathway, which inhibits microglia activation and exerts anti-inflammation, indicating its potential therapeutic effect for neurodegenerative and cerebrovascular diseases.	scutellarin	41-52	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
29680917-6	2018	Overall, the present study suggests that scutellarin inhibits the production of pro-inflammatory mediators via inhibition of the IKK-dependent NF-kappaB and p38/JNK signaling pathway, which inhibits microglia activation and exerts anti-inflammation, indicating its potential therapeutic effect for neurodegenerative and cerebrovascular diseases.	scutellarin	41-52	mitogen-activated protein kinase 14	Mus musculus	157-160
29680917-6	2018	Overall, the present study suggests that scutellarin inhibits the production of pro-inflammatory mediators via inhibition of the IKK-dependent NF-kappaB and p38/JNK signaling pathway, which inhibits microglia activation and exerts anti-inflammation, indicating its potential therapeutic effect for neurodegenerative and cerebrovascular diseases.	scutellarin	41-52	mitogen-activated protein kinase 8	Mus musculus	161-164
29680917-0	2018	Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-kappaB and p38/JNK pathway in LPS-induced BV-2 microglial cells.	scutellarin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
29680917-0	2018	Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-kappaB and p38/JNK pathway in LPS-induced BV-2 microglial cells.	scutellarin	0-11	mitogen-activated protein kinase 14	Mus musculus	85-88
29680917-0	2018	Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-kappaB and p38/JNK pathway in LPS-induced BV-2 microglial cells.	scutellarin	0-11	mitogen-activated protein kinase 8	Mus musculus	89-92
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	tumor necrosis factor	Mus musculus	38-47
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	interleukin 1 beta	Mus musculus	49-57
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	interleukin 6	Mus musculus	59-63
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	tumor necrosis factor	Mus musculus	76-85
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	interleukin 1 beta	Mus musculus	87-95
29375379-6	2017	In this study, we aimed to investigate whether scutellarin could affect the activation of NLRP3 inflammasome in macrophages.	scutellarin	47-58	NLR family, pyrin domain containing 3	Mus musculus	90-95
29487530-0	2018	Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways.	scutellarin	0-11	tumor protein p53	Homo sapiens	135-138
29487530-0	2018	Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways.	scutellarin	0-11	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	143-148
29487530-0	2018	Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways.	scutellarin	0-11	AKT serine/threonine kinase 1	Homo sapiens	149-152
29400110-11	2018	The experimental data demonstrated that scutellarin showed strong hypolipidaemic, antioxidative, and liver protective activity which could be attributed to its regulating activity in the PPARgamma/PGC-1alpha-Nrf2 signaling pathway.	scutellarin	40-51	peroxisome proliferator activated receptor gamma	Homo sapiens	187-196
29400110-11	2018	The experimental data demonstrated that scutellarin showed strong hypolipidaemic, antioxidative, and liver protective activity which could be attributed to its regulating activity in the PPARgamma/PGC-1alpha-Nrf2 signaling pathway.	scutellarin	40-51	PPARG coactivator 1 alpha	Homo sapiens	197-207
29400110-11	2018	The experimental data demonstrated that scutellarin showed strong hypolipidaemic, antioxidative, and liver protective activity which could be attributed to its regulating activity in the PPARgamma/PGC-1alpha-Nrf2 signaling pathway.	scutellarin	40-51	NFE2 like bZIP transcription factor 2	Homo sapiens	208-212
29375379-10	2017	Intriguingly, scutellarin augmented PKA-specific phosphorylation of NLRP3 in LPS-primed macrophages, which was completely blocked by selective PKA inhibitor H89, suggesting that PKA signaling had been involved in the action of scutellarin to suppress NLRP3 inflammasome activation.	scutellarin	14-25	NLR family, pyrin domain containing 3	Mus musculus	68-73
29375379-10	2017	Intriguingly, scutellarin augmented PKA-specific phosphorylation of NLRP3 in LPS-primed macrophages, which was completely blocked by selective PKA inhibitor H89, suggesting that PKA signaling had been involved in the action of scutellarin to suppress NLRP3 inflammasome activation.	scutellarin	14-25	NLR family, pyrin domain containing 3	Mus musculus	251-256
29375379-10	2017	Intriguingly, scutellarin augmented PKA-specific phosphorylation of NLRP3 in LPS-primed macrophages, which was completely blocked by selective PKA inhibitor H89, suggesting that PKA signaling had been involved in the action of scutellarin to suppress NLRP3 inflammasome activation.	scutellarin	227-238	NLR family, pyrin domain containing 3	Mus musculus	68-73
29375379-11	2017	Supporting this, the inhibitory effect of scutellarin on NLRP3 inflammasome activation was completely counteracted by H89 or adenyl cyclase inhibitor MDL12330A.	scutellarin	42-53	NLR family, pyrin domain containing 3	Mus musculus	57-62
29375379-12	2017	As NLRP3-dependent release of IL-1beta has a critical role in sepsis, the in vivo activity of scutellarin was assayed in a mouse model of bacterial sepsis, which was established by intraperitoneally injection of a lethal dose of viable Escherichia coli.	scutellarin	94-105	NLR family, pyrin domain containing 3	Mus musculus	3-8
29375379-12	2017	As NLRP3-dependent release of IL-1beta has a critical role in sepsis, the in vivo activity of scutellarin was assayed in a mouse model of bacterial sepsis, which was established by intraperitoneally injection of a lethal dose of viable Escherichia coli.	scutellarin	94-105	interleukin 1 beta	Mus musculus	30-38
29375379-14	2017	In line with this, scutellarin treatment significantly reduced serum IL-1beta levels and attenuated the infiltration of inflammatory cells in the liver of E. coli-infected mice.	scutellarin	19-30	interleukin 1 beta	Mus musculus	69-77
29375379-15	2017	These data indicated that scutellarin suppressed NLRP3 inflammasome activation in macrophages by augmenting PKA signaling, highlighting its potential therapeutic application for treating NLRP3-related inflammatory diseases.	scutellarin	26-37	NLR family, pyrin domain containing 3	Mus musculus	49-54
29375379-15	2017	These data indicated that scutellarin suppressed NLRP3 inflammasome activation in macrophages by augmenting PKA signaling, highlighting its potential therapeutic application for treating NLRP3-related inflammatory diseases.	scutellarin	26-37	NLR family, pyrin domain containing 3	Mus musculus	187-192
29642616-0	2018	Scutellarin Mitigates Abeta-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice.	scutellarin	0-11	amyloid beta (A4) precursor protein	Mus musculus	22-27
29642616-5	2018	After nine months of treatment in APP/PS1 double-transgenic mice, scutellarin significantly improves behavior, reduces soluble and insoluble Abeta levels in the brain and plasma, decreases Abeta plaque associated gliosis and levels of proinflammatory cytokines TNF-alpha and IL-6, attenuates neuroinflammation, displays anti-amyloidogenic effects, and highlights the beneficial effects of intervention on development or progression of AD-like neuropathology.	scutellarin	66-77	presenilin 1	Mus musculus	38-41
29642616-5	2018	After nine months of treatment in APP/PS1 double-transgenic mice, scutellarin significantly improves behavior, reduces soluble and insoluble Abeta levels in the brain and plasma, decreases Abeta plaque associated gliosis and levels of proinflammatory cytokines TNF-alpha and IL-6, attenuates neuroinflammation, displays anti-amyloidogenic effects, and highlights the beneficial effects of intervention on development or progression of AD-like neuropathology.	scutellarin	66-77	amyloid beta (A4) precursor protein	Mus musculus	141-146
29642616-5	2018	After nine months of treatment in APP/PS1 double-transgenic mice, scutellarin significantly improves behavior, reduces soluble and insoluble Abeta levels in the brain and plasma, decreases Abeta plaque associated gliosis and levels of proinflammatory cytokines TNF-alpha and IL-6, attenuates neuroinflammation, displays anti-amyloidogenic effects, and highlights the beneficial effects of intervention on development or progression of AD-like neuropathology.	scutellarin	66-77	amyloid beta (A4) precursor protein	Mus musculus	189-194
29642616-5	2018	After nine months of treatment in APP/PS1 double-transgenic mice, scutellarin significantly improves behavior, reduces soluble and insoluble Abeta levels in the brain and plasma, decreases Abeta plaque associated gliosis and levels of proinflammatory cytokines TNF-alpha and IL-6, attenuates neuroinflammation, displays anti-amyloidogenic effects, and highlights the beneficial effects of intervention on development or progression of AD-like neuropathology.	scutellarin	66-77	tumor necrosis factor	Mus musculus	261-270
29642616-5	2018	After nine months of treatment in APP/PS1 double-transgenic mice, scutellarin significantly improves behavior, reduces soluble and insoluble Abeta levels in the brain and plasma, decreases Abeta plaque associated gliosis and levels of proinflammatory cytokines TNF-alpha and IL-6, attenuates neuroinflammation, displays anti-amyloidogenic effects, and highlights the beneficial effects of intervention on development or progression of AD-like neuropathology.	scutellarin	66-77	interleukin 6	Mus musculus	275-279
29655699-7	2018	Influences of scutellarin pre-treatment on the levels of reactive oxygen species (ROS), activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase and catalase, and the expression of SOD1 and NADPH oxidase 4 (Nox4) in human umbilical vein endothelial cells (HUVECs) injured by H2O2 were examined.	scutellarin	14-25	superoxide dismutase 1	Homo sapiens	209-213
29655699-7	2018	Influences of scutellarin pre-treatment on the levels of reactive oxygen species (ROS), activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase and catalase, and the expression of SOD1 and NADPH oxidase 4 (Nox4) in human umbilical vein endothelial cells (HUVECs) injured by H2O2 were examined.	scutellarin	14-25	NADPH oxidase 4	Homo sapiens	218-233
29655699-7	2018	Influences of scutellarin pre-treatment on the levels of reactive oxygen species (ROS), activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase and catalase, and the expression of SOD1 and NADPH oxidase 4 (Nox4) in human umbilical vein endothelial cells (HUVECs) injured by H2O2 were examined.	scutellarin	14-25	NADPH oxidase 4	Homo sapiens	235-239
29190543-11	2018	Inappropriate alterations of authophagy markers including beclin-1, LC3 II, mTOR, and P62 were also prevented in the presence of scutellarin.	scutellarin	129-140	beclin 1	Rattus norvegicus	58-66
29190543-11	2018	Inappropriate alterations of authophagy markers including beclin-1, LC3 II, mTOR, and P62 were also prevented in the presence of scutellarin.	scutellarin	129-140	mechanistic target of rapamycin kinase	Rattus norvegicus	76-80
29190543-11	2018	Inappropriate alterations of authophagy markers including beclin-1, LC3 II, mTOR, and P62 were also prevented in the presence of scutellarin.	scutellarin	129-140	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	86-89
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	caspase 1	Mus musculus	61-70
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	interleukin 1 beta	Mus musculus	103-120
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	interleukin 1 beta	Mus musculus	122-130
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	NLR family, pyrin domain containing 3	Mus musculus	260-265
29172017-0	2017	Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats.	scutellarin	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	90-93
29157862-0	2017	Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2.	scutellarin	0-11	pyruvate kinase M1/2	Homo sapiens	83-101
29172017-0	2017	Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats.	scutellarin	0-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	163-167
29218107-0	2017	Scutellarin suppresses human colorectal cancer metastasis and angiogenesis by targeting ephrinb2.	scutellarin	0-11	ephrin B2	Homo sapiens	88-96
29218107-8	2017	Altogether, our results exhibited the evidence that scutellarin inhibit colorectal cancer angiogenesis and metastasis via targeting ephrinb2 signaling, with the potential of an anti-tumor agent for cancer treatment.	scutellarin	52-63	ephrin B2	Homo sapiens	132-140
28849116-0	2017	Effect of Scutellarin inhibits collagen-induced arthritis through TLR4/NF-kappaB-mediated inflammation.	scutellarin	10-21	toll-like receptor 4	Mus musculus	66-70
28809432-0	2017	Intranasal administration of brain-targeted HP-beta-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia.	scutellarin	94-105	beta-carotene oxygenase 1	Mus musculus	47-54
29079722-11	2017	CONCLUSIONS Scutellarin-treated breast carcinoma MCF-7 cells had significantly inhibited growth and induced apoptosis, which is associated with induction of autophagy through regulation of the HIPPO-YAP signaling pathway, providing support to the clinical use of Scutellarin-based medication to achieve optimized outcome in patients with breast carcinoma.	scutellarin	12-23	Yes1 associated transcriptional regulator	Homo sapiens	199-202
28849116-0	2017	Effect of Scutellarin inhibits collagen-induced arthritis through TLR4/NF-kappaB-mediated inflammation.	scutellarin	10-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
28849116-8	2017	The present study demonstrated that scutellarin prevented CIA, and inhibited the expression of inflammation factors, IL-1beta, IL-6 and TNF-alpha.	scutellarin	36-47	interleukin 1 beta	Mus musculus	117-125
28849116-8	2017	The present study demonstrated that scutellarin prevented CIA, and inhibited the expression of inflammation factors, IL-1beta, IL-6 and TNF-alpha.	scutellarin	36-47	interleukin 6	Mus musculus	127-131
28849116-8	2017	The present study demonstrated that scutellarin prevented CIA, and inhibited the expression of inflammation factors, IL-1beta, IL-6 and TNF-alpha.	scutellarin	36-47	tumor necrosis factor	Mus musculus	136-145
28849116-10	2017	Caspase-3/-9, Bax/Bcl-2, TLR4 and NF-kappaB protein expression were reduced in CIA mice following scutellarin treatment.	scutellarin	98-109	caspase 3	Mus musculus	0-12
28849116-10	2017	Caspase-3/-9, Bax/Bcl-2, TLR4 and NF-kappaB protein expression were reduced in CIA mice following scutellarin treatment.	scutellarin	98-109	BCL2-associated X protein	Mus musculus	14-17
28849116-10	2017	Caspase-3/-9, Bax/Bcl-2, TLR4 and NF-kappaB protein expression were reduced in CIA mice following scutellarin treatment.	scutellarin	98-109	B cell leukemia/lymphoma 2	Mus musculus	18-23
28849116-10	2017	Caspase-3/-9, Bax/Bcl-2, TLR4 and NF-kappaB protein expression were reduced in CIA mice following scutellarin treatment.	scutellarin	98-109	toll-like receptor 4	Mus musculus	25-29
28849116-10	2017	Caspase-3/-9, Bax/Bcl-2, TLR4 and NF-kappaB protein expression were reduced in CIA mice following scutellarin treatment.	scutellarin	98-109	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-43
28249594-4	2017	In this study, we formulated and characterized a novel intestinal target nanoparticle carrier based on amphiphilic chitosan derivatives (Chit-DC-VB12) loaded with scutellarin to enhance its bioavailability and then evaluated its therapeutic effect in experimental diabetic retinopathy model.	scutellarin	163-174	chitinase 1	Homo sapiens	137-141
28315259-7	2017	Cotreatment with scutellarin significantly decreased the LDH activity (2595.9 +- 72.73), MDA level (1.380 +- 0.06), cTnT concentration (0.0222 +- 0.0041 ng/m L), increased LVEF (76.70 +- 3.91) and LVFS (40.28 +- 3.68).	scutellarin	17-28	troponin T2, cardiac type	Rattus norvegicus	116-120
32104349-1	2017	The aim of this paper is to investigate and optimize the preparation of scutellarin (SCU)-loaded HP-beta-CD/chitosan (CS) nanoparticles (CD/CS-SCU-NPs).	scutellarin	72-83	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	100-107
28249594-10	2017	Bioavailability studies were performed in Sprague-Dawley rats, which present the area under the curve of scutellarin of Chit-DC-VB12-Scu was two to threefolds greater than that of free scutellarin alone.	scutellarin	105-116	chitinase 1	Homo sapiens	120-124
28249594-13	2017	In conclusion, the Chit-DC-VB12 nanoparticles enhanced scutellarin oral delivery efficacy and exhibited potential as small intestinal target promising nano-carriers for treatment of type II diabetes induced-retinopathy.	scutellarin	55-66	chitinase 1	Homo sapiens	19-23
27586020-5	2016	Results showed that at nontoxic concentrations, Cremophor EL enhanced the transportation of scutellarin by MRP3 and inhibited the efflux transportation of scutellarin by MRP2 and BCRP concurrently.	scutellarin	92-103	ATP binding cassette subfamily C member 3	Rattus norvegicus	107-111
28035355-0	2017	Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway.	scutellarin	0-11	tumor protein p53	Homo sapiens	102-105
28035355-9	2017	Additionally, suppression of p53 using a specific inhibitor, pifithrin-alpha, abrogated the pro-apoptotic effects of Scutellarin in HCT-116 cells.	scutellarin	117-128	tumor protein p53	Homo sapiens	29-32
27998773-8	2017	Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling.	scutellarin	0-11	signal transducer and activator of transcription 3	Homo sapiens	112-117
27998773-8	2017	Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling.	scutellarin	0-11	coiled-coil domain containing 88A	Homo sapiens	118-124
27998773-8	2017	Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling.	scutellarin	0-11	AKT serine/threonine kinase 1	Homo sapiens	125-128
27903431-7	2017	In contrast, Akt inhibitor and knockdown of Akt with siRNA decreased scutellarin-stimulated glucose uptake but had no effects on baicalin.	scutellarin	69-80	thymoma viral proto-oncogene 1	Mus musculus	44-47
27742373-0	2016	Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats.	scutellarin	0-11	mitogen-activated protein kinase 7	Rattus norvegicus	45-49
27742373-0	2016	Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats.	scutellarin	0-11	Kruppel-like factor 2	Rattus norvegicus	50-54
26730961-0	2016	Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor.	scutellarin	26-37	angiotensin I converting enzyme	Rattus norvegicus	103-132
26514969-10	2016	Further analysis revealed that scutellarin might suppress the phosphorylation of p38 in cuprizone-induced NSCs.	scutellarin	31-42	mitogen-activated protein kinase 14	Mus musculus	81-84
26730961-0	2016	Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor.	scutellarin	26-37	angiotensin II receptor, type 1a	Rattus norvegicus	137-140
26730961-2	2016	In the present study, we investigated whether Scutellarin (Scu) exerts neuroprotective effects by down-regulating the Expression of Angiotensin-Converting Enzyme and AT1 receptor in a rat model of permanent focal cerebral ischemia.	scutellarin	46-57	angiotensin I converting enzyme	Rattus norvegicus	132-161
26730961-2	2016	In the present study, we investigated whether Scutellarin (Scu) exerts neuroprotective effects by down-regulating the Expression of Angiotensin-Converting Enzyme and AT1 receptor in a rat model of permanent focal cerebral ischemia.	scutellarin	46-57	angiotensin II receptor, type 1a	Rattus norvegicus	166-169
26557858-0	2015	Scutellarin Reduces Endothelium Dysfunction through the PKG-I Pathway.	scutellarin	0-11	protein kinase cGMP-dependent 1	Rattus norvegicus	56-61
25858254-8	2016	RESULTS: Our results showed that mulberrin, scutellarin, quercetin, and glycyrrhetinic acid were strong inhibitors of OATP2B1-mediate E3S uptake with IC50 values being 1.8, 2.0, 7.5, and 13.0 muM, which were comparable with their plasma concentrations in clinical trials.	scutellarin	44-55	solute carrier organic anion transporter family member 2B1	Homo sapiens	118-125
25858254-8	2016	RESULTS: Our results showed that mulberrin, scutellarin, quercetin, and glycyrrhetinic acid were strong inhibitors of OATP2B1-mediate E3S uptake with IC50 values being 1.8, 2.0, 7.5, and 13.0 muM, which were comparable with their plasma concentrations in clinical trials.	scutellarin	44-55	latexin	Homo sapiens	192-195
26730179-6	2016	Increased expression of neurotrophic factors in vitro and in vivo is the mechanism of neurotrophic action of flavonoids such as scutellarin, daidzein, genistein, and fisetin, while compounds like apigenin and ferulic acid increase cyclic adenosine monophosphate response element-binding protein (CREB) phosphorylation.	scutellarin	128-139	cAMP responsive element binding protein 1	Rattus norvegicus	296-300
25861655-0	2015	Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat.	scutellarin	22-33	BCL2, apoptosis regulator	Rattus norvegicus	125-130
25861655-0	2015	Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat.	scutellarin	22-33	BCL2 associated X, apoptosis regulator	Rattus norvegicus	131-134
25416145-9	2014	Furthermore, Edaravone and Scutellarin in combination cumulatively diminished the expression levels of the inflammatory mediators being most pronounced for TNF-alpha as evidenced by Western blot.	scutellarin	27-38	tumor necrosis factor	Rattus norvegicus	156-165
25073400-0	2014	In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats.	scutellarin	19-30	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	52-58
25192544-0	2014	Scutellarin inhibits high glucose-induced and hypoxia-mimetic agent-induced angiogenic effects in human retinal endothelial cells through reactive oxygen species/hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway.	scutellarin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-193
25192544-0	2014	Scutellarin inhibits high glucose-induced and hypoxia-mimetic agent-induced angiogenic effects in human retinal endothelial cells through reactive oxygen species/hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway.	scutellarin	0-11	vascular endothelial growth factor A	Homo sapiens	194-228
25192544-1	2014	Scutellarin inhibits hypoxia-induced and moderately high glucose-induced proliferation and vascular endothelial growth factor (VEGF) expression in human retinal endothelial cells (HRECs); thus, it could be a potential therapy for diabetic retinopathy.	scutellarin	0-11	vascular endothelial growth factor A	Homo sapiens	91-125
25192544-1	2014	Scutellarin inhibits hypoxia-induced and moderately high glucose-induced proliferation and vascular endothelial growth factor (VEGF) expression in human retinal endothelial cells (HRECs); thus, it could be a potential therapy for diabetic retinopathy.	scutellarin	0-11	vascular endothelial growth factor A	Homo sapiens	127-131
25192544-6	2014	We found that scutellarin not only concentration-dependently inhibited cell proliferation, migration, and tube formation in HRECs but also decreased their production of VEGF.	scutellarin	14-25	vascular endothelial growth factor A	Homo sapiens	169-173
25192544-8	2014	Furthermore, scutellarin impaired the interaction of HIF-1alpha with p300, which further decreased the transcriptional activity of HIF-1alpha.	scutellarin	13-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
25192544-8	2014	Furthermore, scutellarin impaired the interaction of HIF-1alpha with p300, which further decreased the transcriptional activity of HIF-1alpha.	scutellarin	13-24	E1A binding protein p300	Homo sapiens	69-73
25192544-8	2014	Furthermore, scutellarin impaired the interaction of HIF-1alpha with p300, which further decreased the transcriptional activity of HIF-1alpha.	scutellarin	13-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
25192544-9	2014	As an inducer of HIF-1alpha, oxidative stress was attenuated by scutellarin.	scutellarin	64-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
25073400-0	2014	In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats.	scutellarin	19-30	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	60-67
25073400-0	2014	In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats.	scutellarin	19-30	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	69-75
25073400-0	2014	In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats.	scutellarin	19-30	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	81-87
25073400-1	2014	OBJECTIVE: To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo.	scutellarin	43-54	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	76-82
25073400-1	2014	OBJECTIVE: To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo.	scutellarin	43-54	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	84-91
25073400-1	2014	OBJECTIVE: To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo.	scutellarin	43-54	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	93-99
25073400-1	2014	OBJECTIVE: To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo.	scutellarin	43-54	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	105-111
25073400-5	2014	RESULTS: The activity of CYP1A2 in rats was inhibited significantly after treatment with scutellarin by increased caffeine t1/2 (21.76%, P &lt; 0.05), T(max) (43.05%, P &lt; 0.05), C(max) (43.92%, P &lt; 0.01) and AUC(0-infinity) (50.88%, P &lt; 0.01) in the scutellarin-treated group compared with those of the blank control.	scutellarin	89-100	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	25-31
25073400-5	2014	RESULTS: The activity of CYP1A2 in rats was inhibited significantly after treatment with scutellarin by increased caffeine t1/2 (21.76%, P &lt; 0.05), T(max) (43.05%, P &lt; 0.05), C(max) (43.92%, P &lt; 0.01) and AUC(0-infinity) (50.88%, P &lt; 0.01) in the scutellarin-treated group compared with those of the blank control.	scutellarin	259-270	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	25-31
25073400-6	2014	The activity of CYP2C11 in rats was inhibited significantly after treatment with scutellarin by increased tolbutamide t1/2 (16.74%, P &lt; 0.01), T(max) (116.87%, P &lt; 0.05), C(max) (63.78%, P &lt; 0.01) and AUC(0-infinity) (70.61%, P &lt; 0.01) in the scutellarin-treated group compared with those of the blank control.	scutellarin	81-92	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	16-23
25073400-6	2014	The activity of CYP2C11 in rats was inhibited significantly after treatment with scutellarin by increased tolbutamide t1/2 (16.74%, P &lt; 0.01), T(max) (116.87%, P &lt; 0.05), C(max) (63.78%, P &lt; 0.01) and AUC(0-infinity) (70.61%, P &lt; 0.01) in the scutellarin-treated group compared with those of the blank control.	scutellarin	255-266	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	16-23
25073400-7	2014	The activity of CYP3A1/2 in rats was inhibited significantly after treatment with scutellarin by increased dapsone t1/2 (45.28%, P &lt; 0.05), T(max) (81.55%, P &lt; 0.05), C(max) (155.58%, P &lt; 0.01)and AUC(0-infinity) (176.35%, P &lt; 0.01) in the scutellarin-treated group compared with those of the blank control.	scutellarin	82-93	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	16-22
25073400-7	2014	The activity of CYP3A1/2 in rats was inhibited significantly after treatment with scutellarin by increased dapsone t1/2 (45.28%, P &lt; 0.05), T(max) (81.55%, P &lt; 0.05), C(max) (155.58%, P &lt; 0.01)and AUC(0-infinity) (176.35%, P &lt; 0.01) in the scutellarin-treated group compared with those of the blank control.	scutellarin	252-263	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	16-22
25073400-9	2014	CONCLUSION: Scutellarin could significantly inhibit CYP1A2, CYP2C11 and CYP3A1/2 activities in rats in vivo, but had no effects on the activity of CYP2D1.	scutellarin	12-23	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	52-58
25073400-9	2014	CONCLUSION: Scutellarin could significantly inhibit CYP1A2, CYP2C11 and CYP3A1/2 activities in rats in vivo, but had no effects on the activity of CYP2D1.	scutellarin	12-23	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	60-67
25073400-9	2014	CONCLUSION: Scutellarin could significantly inhibit CYP1A2, CYP2C11 and CYP3A1/2 activities in rats in vivo, but had no effects on the activity of CYP2D1.	scutellarin	12-23	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	72-78