PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33500273-7	2021	We demonstrate that nNOS-implicated mechanisms in NAc shell (NAcSh), including increased cell number, increased protein expression levels and increased specific enzyme activity, contribute the susceptibility to social defeat and the following depression-like behaviors.	nacsh	61-66	nitric oxide synthase 1, neuronal	Mus musculus	20-24
34424532-2	2021	Because CREB-binding protein (CBP) promotes Per1 gene expression, we hypothesized that alcohol consumption would increase CBP expression in the NAcSh and antisense-induced knockdown of CBP would reduce Per1 expression and result in a reduction in alcohol consumption.	nacsh	144-149	CREB binding protein	Mus musculus	8-28
34424532-2	2021	Because CREB-binding protein (CBP) promotes Per1 gene expression, we hypothesized that alcohol consumption would increase CBP expression in the NAcSh and antisense-induced knockdown of CBP would reduce Per1 expression and result in a reduction in alcohol consumption.	nacsh	144-149	CREB binding protein	Mus musculus	30-33
34424532-2	2021	Because CREB-binding protein (CBP) promotes Per1 gene expression, we hypothesized that alcohol consumption would increase CBP expression in the NAcSh and antisense-induced knockdown of CBP would reduce Per1 expression and result in a reduction in alcohol consumption.	nacsh	144-149	CREB binding protein	Mus musculus	122-125
34424532-12	2021	CONCLUSIONS: Our results suggest that CBP is an upstream regulator of Per1 expression in the NAcSh and may act via Per1 to modulate alcohol consumption.	nacsh	93-98	CREB binding protein	Mus musculus	38-41
33979617-4	2021	NAcSh-projecting IL neurons are activated when GH mice encounter a familiar conspecific, which is not observed in SH mice.	nacsh	0-5	growth hormone	Mus musculus	47-49
33500273-12	2021	Therefore, NAcSh nNOS mediates susceptibility to social defeat stress and the depression-like behaviors through CDK5.SIGNIFICANCE STATEMENT:Stress-induced depression is common worldwide and chronic exposure to social and psychological stressors is important cause of human depression.	nacsh	11-16	nitric oxide synthase 1	Homo sapiens	17-21
33500273-12	2021	Therefore, NAcSh nNOS mediates susceptibility to social defeat stress and the depression-like behaviors through CDK5.SIGNIFICANCE STATEMENT:Stress-induced depression is common worldwide and chronic exposure to social and psychological stressors is important cause of human depression.	nacsh	11-16	cyclin dependent kinase 5	Homo sapiens	112-116
33500273-14	2021	Moreover, we discover the downstream mechanism of NAcSh nNOS in mediating the susceptibility is NO and S-nitrosylation of CDK5.	nacsh	50-55	nitric oxide synthase 1, neuronal	Mus musculus	56-60
33500273-14	2021	Moreover, we discover the downstream mechanism of NAcSh nNOS in mediating the susceptibility is NO and S-nitrosylation of CDK5.	nacsh	50-55	cyclin-dependent kinase 5	Mus musculus	122-126
33500273-15	2021	Thus, NAcSh nNOS mediates susceptibility to social defeat stress through CDK5 is a potential mechanism for depression, which may interpret how the brain transduces social stress exposure into depression.	nacsh	6-11	nitric oxide synthase 1, neuronal	Mus musculus	12-16
33500273-15	2021	Thus, NAcSh nNOS mediates susceptibility to social defeat stress through CDK5 is a potential mechanism for depression, which may interpret how the brain transduces social stress exposure into depression.	nacsh	6-11	cyclin-dependent kinase 5	Mus musculus	73-77
29165386-2	2017	We have previously demonstrated that systemic administration of ghrelin antagonist (JMV2959) significantly decreased morphine-induced dopamine and anandamide (N-arachidonoylethanolamine, AEA) increase in the NACSh.	nacsh	208-213	ghrelin and obestatin prepropeptide	Rattus norvegicus	64-71
32353460-6	2020	An inhibitor of GRalpha, microRNA-124-3p (miR124-3p) was significantly higher in the NAcsh, and GC-induced gene, GILZ, as a measure of GC-responsiveness, was significantly lower.	nacsh	85-90	microRNA 124-3	Rattus norvegicus	25-40
32353460-6	2020	An inhibitor of GRalpha, microRNA-124-3p (miR124-3p) was significantly higher in the NAcsh, and GC-induced gene, GILZ, as a measure of GC-responsiveness, was significantly lower.	nacsh	85-90	microRNA 124-3	Rattus norvegicus	42-51
33340384-12	2021	In addition, immunohistochemistry revealed that DHT treatment of GDX animals rapidly increased the number of cell bodies in the NAcSh positive for phosphorylated cAMP response-element binding protein, a downstream messenger of the androgen receptor.	nacsh	128-133	androgen receptor	Rattus norvegicus	231-248
29880884-6	2020	Subsequently, sigma1 binds to Kv1.2 potassium channels, followed by accumulation of Kv1.2 in the plasma membrane, thereby depressing NAcSh MSNs firing.	nacsh	133-138	potassium voltage-gated channel subfamily A member 2	Homo sapiens	84-89
30213620-8	2018	Our results suggest that activation of the NR1-CaMKII-ERK pathway in the mPFC and NAcSh is an important contributor to the molecular mechanisms underlying alcohol withdrawal-induced anxiety behaviors.	nacsh	82-87	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	43-46
28044061-6	2018	Lentiviral-mediated miR-495 overexpression in the NAc shell (NAcsh) not only reversed these cocaine-induced effects but also downregulated multiple ARG mRNAs in specific SUD-related biological pathways, including those that regulate synaptic plasticity.	nacsh	61-66	microRNA 495	Rattus norvegicus	20-27
29217682-4	2018	Therefore, we hypothesized that HSV-mediated G9a overexpression in the NAc shell (NAcSh) would attenuate cocaine self-administration (SA) and cocaine-seeking behavior.	nacsh	82-87	euchromatic histone lysine methyltransferase 2	Rattus norvegicus	45-48
27105831-1	2016	BACKGROUND: Neuromedin U (NMU) is a neuropeptide enriched in the nucleus accumbens shell (NAcSh), a brain region associated with reward.	nacsh	90-95	neuromedin U	Homo sapiens	12-24
28808012-2	2017	Here we show that brain-derived neurotrophic factor (BDNF) signaling through tyrosine kinase B (TrkB) receptors in NACsh neurons is necessary for cocaine-induced dendritic spine formation by using either localized TrkB knockout or viral-mediated expression of a dominant negative, kinase-dead TrkB mutant.	nacsh	115-120	brain derived neurotrophic factor	Homo sapiens	18-51
28808012-2	2017	Here we show that brain-derived neurotrophic factor (BDNF) signaling through tyrosine kinase B (TrkB) receptors in NACsh neurons is necessary for cocaine-induced dendritic spine formation by using either localized TrkB knockout or viral-mediated expression of a dominant negative, kinase-dead TrkB mutant.	nacsh	115-120	brain derived neurotrophic factor	Homo sapiens	53-57
28808012-2	2017	Here we show that brain-derived neurotrophic factor (BDNF) signaling through tyrosine kinase B (TrkB) receptors in NACsh neurons is necessary for cocaine-induced dendritic spine formation by using either localized TrkB knockout or viral-mediated expression of a dominant negative, kinase-dead TrkB mutant.	nacsh	115-120	neurotrophic receptor tyrosine kinase 2	Homo sapiens	96-100
28419874-4	2017	We determined, in adult Wistar rats, if the orally available KAT II inhibitor BFF816 a) prevents KYNA elevations in prefrontal cortex (PFC) after a systemic kynurenine injection and b) reverses the kynurenine-induced attenuation of evoked prefrontal glutamate release caused by stimulation of the nucleus accumbens shell (NAcSh).	nacsh	322-327	aminoadipate aminotransferase	Rattus norvegicus	61-67
28039192-5	2017	Here, we explored the contribution of orexin signaling in rostral LH and NAcSh to the HA/LA phenotype.	nacsh	73-78	hypocretin neuropeptide precursor	Rattus norvegicus	38-44
28039192-9	2017	Pretreatment with muscimol, a GABAA receptor agonist, in NAcSh potentiated SPA produced by orexin-A injection in rostral LH in HA but not in LA rats.	nacsh	57-62	hypocretin neuropeptide precursor	Rattus norvegicus	91-99
28039192-11	2017	Overall, our data suggest that differences in orexin sensitivity in rostral LH and its modulation by GABA afferents from NAcSh contribute to individual SPA differences.	nacsh	121-126	hypocretin neuropeptide precursor	Rattus norvegicus	46-52
28860990-7	2017	Thus, loss of ALK activity in mice is associated with elevated ethanol consumption and enhanced excitatory transmission in NAcSh D1MSNs.	nacsh	123-128	anaplastic lymphoma kinase	Mus musculus	14-17
28126496-9	2017	These results suggest that silencing of GSK3beta in the NAcSh increases depression- and addiction-related behavior, possibly by decreasing intrinsic excitability of TANs.	nacsh	56-61	glycogen synthase kinase 3 beta	Homo sapiens	40-48
27105831-1	2016	BACKGROUND: Neuromedin U (NMU) is a neuropeptide enriched in the nucleus accumbens shell (NAcSh), a brain region associated with reward.	nacsh	90-95	neuromedin U	Homo sapiens	26-29
27105831-4	2016	METHODS: Immunohistochemistry was used to determine the synaptic localization of NMUR2 in the NAcSh and characterize which neurons express this receptor (n = 17).	nacsh	94-99	neuromedin U receptor 2	Homo sapiens	81-86
27105831-6	2016	The behavioral effects of NMU microinjection directly to the NAcSh were investigated using cocaine-evoked locomotion (n = 93).	nacsh	61-66	neuromedin U	Homo sapiens	26-29
27105831-8	2016	RESULTS: NMUR2 is localized to presynaptic gamma-aminobutyric acidergic nerve terminals in the NAcSh originating from the dorsal raphe nucleus.	nacsh	95-100	neuromedin U receptor 2	Homo sapiens	9-14
27105831-9	2016	Furthermore, NMU microinjection to the NAcSh decreased local gamma-aminobutyric acid concentrations.	nacsh	39-44	neuromedin U	Homo sapiens	13-16
27105831-12	2016	Additionally, small hairpin RNA-mediated knockdown of presynaptic NMUR2 in the NAcSh using a retrograde viral vector potentiated cocaine sensitization.	nacsh	79-84	neuromedin U receptor 2	Homo sapiens	66-71
27105831-13	2016	CONCLUSIONS: Together, these data reveal that NMUR2 modulates a novel gamma-aminobutyric acidergic pathway from the dorsal raphe nucleus to the NAcSh to influence behavioral responses to cocaine.	nacsh	144-149	neuromedin U receptor 2	Homo sapiens	46-51
26898297-8	2016	Importantly, the novelty-seeking behavior in the large open field induced a higher level of c-Fos activation in the nucleus accumbens shell (NAcSh) in TLR4(-/-) mice than in WT mice.	nacsh	141-146	FBJ osteosarcoma oncogene	Mus musculus	92-97
27899881-8	2016	Subsequent knockdown of Cyp26b1 (an RA degradation enzyme) in the NAcSh of rats confirmed this role by increasing cocaine self-administration as well as cocaine seeking.	nacsh	66-71	cytochrome P450, family 26, subfamily b, polypeptide 1	Rattus norvegicus	24-31
27074815-6	2016	Using lentiviral miRZip-365 constructs selectively expressed in Pdyn-neurons of the NAcSh, we demonstrated that the Pdyn-miR365 interaction in the NAcSh directly influences novelty-seeking exploratory behavior and facilitates self-administration of natural reward.	nacsh	84-89	prodynorphin	Homo sapiens	64-68
27074815-6	2016	Using lentiviral miRZip-365 constructs selectively expressed in Pdyn-neurons of the NAcSh, we demonstrated that the Pdyn-miR365 interaction in the NAcSh directly influences novelty-seeking exploratory behavior and facilitates self-administration of natural reward.	nacsh	84-89	prodynorphin	Homo sapiens	116-120
27074815-6	2016	Using lentiviral miRZip-365 constructs selectively expressed in Pdyn-neurons of the NAcSh, we demonstrated that the Pdyn-miR365 interaction in the NAcSh directly influences novelty-seeking exploratory behavior and facilitates self-administration of natural reward.	nacsh	147-152	prodynorphin	Homo sapiens	64-68
27074815-6	2016	Using lentiviral miRZip-365 constructs selectively expressed in Pdyn-neurons of the NAcSh, we demonstrated that the Pdyn-miR365 interaction in the NAcSh directly influences novelty-seeking exploratory behavior and facilitates self-administration of natural reward.	nacsh	147-152	prodynorphin	Homo sapiens	116-120
27044354-4	2016	MCH has been shown to potentiate responses to dopamine and to increase phosphorylation of DARPP-32, an intracellular marker of DA receptor activation, in the NAcSh.	nacsh	158-163	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	90-98
27044354-9	2016	The increase in DARPP-32 phosphorylation seen in wildtype (WT) mice after acute alcohol administration in the NAcSh was markedly reduced in MCH1-R knock-out (KO) mice.	nacsh	110-115	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	16-24
26898297-8	2016	Importantly, the novelty-seeking behavior in the large open field induced a higher level of c-Fos activation in the nucleus accumbens shell (NAcSh) in TLR4(-/-) mice than in WT mice.	nacsh	141-146	toll-like receptor 4	Mus musculus	151-155
26898297-9	2016	Partially inactivating the NAcSh via infusion of GABA receptor agonists restored the novelty-seeking behavior of TLR4(-/-) mice.	nacsh	27-32	toll-like receptor 4	Mus musculus	113-117
26898297-11	2016	TLR4-dependent activation of neurons in the NAcSh may contribute to this phenomenon.	nacsh	44-49	toll-like receptor 4	Mus musculus	0-4
20843634-2	2011	The present study examined whether increasing 5-HT(1B) receptors expressed on NAcSh projection neurons by means of virus-mediated gene transfer enhances ethanol consumption during the initiation or maintenance phase of drinking and alters the temporal pattern of drinking behavior.	nacsh	78-83	5-hydroxytryptamine receptor 1B	Rattus norvegicus	46-53
26507196-4	2016	The goal of the present study was to test whether the growth hormone secretagogue receptor (GHS-R1A) antagonist JMV2959 was able to influence morphine-induced effects on anandamide (N-arachidonoylethanolamine, AEA) and 2-arachidonoylglycerol (2-AG) in the nucleus accumbens shell (NACSh).	nacsh	281-286	growth hormone secretagogue receptor	Rattus norvegicus	54-90
26030405-2	2015	Although glycogen synthase kinase 3beta (GSK3beta) signaling in the nucleus accumbens (NAc) plays a key role in mediating dopamine (DA)-dependent behaviors, there is less direct evidence that how VPA acts on the GSK3beta signaling in the functionally distinct sub-regions of the NAc, the NAc core (NAcC) and the NAc shell (NAcSh), during psycho-stimulant-induced hyperactivity.	nacsh	323-328	glycogen synthase kinase 3 beta	Rattus norvegicus	41-49
24469593-9	2014	These effects appear to involve a role for mTORC1 in the regulation of GluA1 AMPARs and CAMKIIalpha in the NACsh.	nacsh	107-112	CREB regulated transcription coactivator 1	Mus musculus	43-49
24469593-9	2014	These effects appear to involve a role for mTORC1 in the regulation of GluA1 AMPARs and CAMKIIalpha in the NACsh.	nacsh	107-112	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	71-76
24133421-3	2013	The nucleus accumbens shell (NAcSh), best known for its role in appetitive and negative motivation via dopamine receptors, is likely to be the potential important brain area where the orexin system mediates stress-induced drug relapse since the function of dopamine system in the NAcSh can be regulated by orexin transmission.	nacsh	29-34	hypocretin neuropeptide precursor	Homo sapiens	184-190
24133421-3	2013	The nucleus accumbens shell (NAcSh), best known for its role in appetitive and negative motivation via dopamine receptors, is likely to be the potential important brain area where the orexin system mediates stress-induced drug relapse since the function of dopamine system in the NAcSh can be regulated by orexin transmission.	nacsh	29-34	hypocretin neuropeptide precursor	Homo sapiens	306-312
24133421-3	2013	The nucleus accumbens shell (NAcSh), best known for its role in appetitive and negative motivation via dopamine receptors, is likely to be the potential important brain area where the orexin system mediates stress-induced drug relapse since the function of dopamine system in the NAcSh can be regulated by orexin transmission.	nacsh	280-285	hypocretin neuropeptide precursor	Homo sapiens	184-190
24133421-5	2013	The results showed that blockade of orexin-1 or orexin-2 receptor in the NAcSh significantly attenuated stress-induced morphine CPP reinstatement, but neither of the orexin antagonists had any effect on morphine priming-induced reinstatement.	nacsh	73-78	hypocretin neuropeptide precursor	Homo sapiens	36-42
24133421-5	2013	The results showed that blockade of orexin-1 or orexin-2 receptor in the NAcSh significantly attenuated stress-induced morphine CPP reinstatement, but neither of the orexin antagonists had any effect on morphine priming-induced reinstatement.	nacsh	73-78	hypocretin neuropeptide precursor	Homo sapiens	48-54
24133421-5	2013	The results showed that blockade of orexin-1 or orexin-2 receptor in the NAcSh significantly attenuated stress-induced morphine CPP reinstatement, but neither of the orexin antagonists had any effect on morphine priming-induced reinstatement.	nacsh	73-78	hypocretin neuropeptide precursor	Homo sapiens	48-54
26403083-9	2015	CONCLUSION: These findings show that CRF-R2 in the VTA is necessary for acute and repeated stress-induced dopamine efflux in the NAcSh, but is only recruited into mPFC-projecting dopamine neurons with repeated stress exposure.	nacsh	129-134	corticotropin releasing hormone receptor 2	Rattus norvegicus	37-43
25178815-8	2015	The effects of acute injection of BPN and the KOR agonist U50,488 were measured on extracellular dopamine (DA) levels in the NAcSh.	nacsh	125-130	opioid receptor, kappa 1	Mus musculus	46-49
24231358-5	2013	DREAMM revealed discrete behavioral manifestations and concurrent engagement of distinct corticolimbic networks associated with dysregulation of Pdyn and Penk in MSNs of the NAcSh.	nacsh	174-179	proenkephalin	Homo sapiens	154-158
22683090-4	2012	METHODS: To investigate the functional significance of NAcsh Penk tone, selective viral-mediated knockdown and overexpression of Penk was performed, followed by analysis of subsequent heroin SA behavior.	nacsh	55-60	proenkephalin	Rattus norvegicus	61-65
22683090-6	2012	RESULTS: Here we show that regulation of the Penk opioid neuropeptide gene in NAcsh directly regulates heroin SA behavior.	nacsh	78-83	proenkephalin	Rattus norvegicus	45-49
22683090-6	2012	RESULTS: Here we show that regulation of the Penk opioid neuropeptide gene in NAcsh directly regulates heroin SA behavior.	nacsh	78-83	pyroglutamylated RFamide peptide	Rattus norvegicus	57-69
22683090-8	2012	Furthermore, we report that adolescent THC exposure mediates Penk upregulation through reduction of histone H3 lysine 9 (H3K9) methylation in the NAcsh, thereby disrupting the normal developmental pattern of H3K9 methylation.	nacsh	146-151	proenkephalin	Rattus norvegicus	61-65
22683090-9	2012	CONCLUSIONS: These data establish a direct association between THC-induced NAcsh Penk upregulation and heroin SA and indicate that epigenetic dysregulation of Penk underlies the long-term effects of THC.	nacsh	75-80	proenkephalin	Rattus norvegicus	81-85
21172385-4	2011	Since activation of extracellular signal-related kinase (ERK2) is involved in the rewarding effects of several classes of drugs of abuse, we then measured the level of ERK2 phosphorylation in the nucleus accumbens shell (NACsh) and core (NACco) of GAL-/- and GAL+/+ mice following re-exposure to the CPP chamber previously paired with nicotine as a marker of mesolimbic system activation.	nacsh	221-226	mitogen-activated protein kinase 1	Mus musculus	57-61
21172385-4	2011	Since activation of extracellular signal-related kinase (ERK2) is involved in the rewarding effects of several classes of drugs of abuse, we then measured the level of ERK2 phosphorylation in the nucleus accumbens shell (NACsh) and core (NACco) of GAL-/- and GAL+/+ mice following re-exposure to the CPP chamber previously paired with nicotine as a marker of mesolimbic system activation.	nacsh	221-226	mitogen-activated protein kinase 1	Mus musculus	168-172
21172385-7	2011	In the conditioning groups showing significant expression of nicotine CPP, only GAL+/+ mice showed ERK2 activation in the NACsh.	nacsh	122-127	mitogen-activated protein kinase 1	Mus musculus	99-103
21172385-8	2011	This suggests that the nicotine CPP observed in GAL+/+ mice resulted in differential recruitment of ERK signaling in the NACsh compared to GAL-/- mice.	nacsh	121-126	mitogen-activated protein kinase 1	Mus musculus	100-103
16300424-4	2005	In a separate experiment, a low, behaviorally relevant dose of cocaine was found to increase c-Fos immunoreactivity in the medial CPu, NAcC, and nucleus accumbens shell (NAcSh).	nacsh	170-175	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-98
19416746-4	2009	Whole cell patch clamp recording in vitro revealed that ORX-A and ORX-B depolarize NAcSh neurons in normal and/or tetrodotoxin (TTX)-containing artificial cerebrospinal fluid (ACSF).	nacsh	83-88	hypocretin neuropeptide precursor	Rattus norvegicus	56-61
19342492-3	2009	Melanin-concentrating hormone (MCH) is produced mainly in the LH, and its receptor (MCH1R) is highly expressed in the NAcSh.	nacsh	118-123	melanin-concentrating hormone receptor 1	Mus musculus	84-89
19342492-4	2009	We found that, in the NAcSh, MCH1R is coexpressed with dopamine receptors (D1R and D2R), and that MCH increases spike firing when both D1R and D2R are activated.	nacsh	22-27	melanin-concentrating hormone receptor 1	Mus musculus	29-34
19151710-5	2009	We found that decreased CREB activity in NAcSh correlated with increased expression of certain K(+) channels and reduced electrical excitability of NAcSh neurons, which was sufficient to induce anxiety-like behaviors and was reversed by chronic antidepressant treatment.	nacsh	41-46	cAMP responsive element binding protein 1	Homo sapiens	24-28
19151710-5	2009	We found that decreased CREB activity in NAcSh correlated with increased expression of certain K(+) channels and reduced electrical excitability of NAcSh neurons, which was sufficient to induce anxiety-like behaviors and was reversed by chronic antidepressant treatment.	nacsh	148-153	cAMP responsive element binding protein 1	Homo sapiens	24-28
19151710-6	2009	Together, our results describe a model that distinguishes anxiety- and depression-like behavioral phenotypes, establish a selective role of decreased CREB activity in NAcSh in anxiety-like behavior, and provide a mechanism by which antidepressant treatment alleviates anxiety symptoms after social isolation.	nacsh	167-172	cAMP responsive element binding protein 1	Homo sapiens	150-154
16565962-8	2006	Furthermore, single PVT cells retrogradely labeled from the NacSh were apposed by both orexin and CART fibers.	nacsh	60-65	hypocretin neuropeptide precursor	Homo sapiens	87-93
16565962-8	2006	Furthermore, single PVT cells retrogradely labeled from the NacSh were apposed by both orexin and CART fibers.	nacsh	60-65	CART prepropeptide	Homo sapiens	98-102
16300424-5	2005	The selective 5-HT2A receptor antagonist M100907 significantly attenuated cocaine-induced c-Fos expression in the medial CPu and in the NAcSh.	nacsh	136-141	5-hydroxytryptamine receptor 2A	Rattus norvegicus	14-20
16300424-5	2005	The selective 5-HT2A receptor antagonist M100907 significantly attenuated cocaine-induced c-Fos expression in the medial CPu and in the NAcSh.	nacsh	136-141	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	90-95