PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16632588-8	2006	Treatment with brassinazole, an inhibitor of BR biosynthesis, also partially rescued the tropic defects in nph4-103.	brassinazole	15-27	Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein	Arabidopsis thaliana	107-111
14676973-4	2003	Investigation of target site(s) of brassinazole revealed that the compound directly binds to the DWF4 protein, a cytochrome P450 monooxygenase that catalyzes 22-hydroxylation of the side chain of BRs.	brassinazole	35-47	Cytochrome P450 superfamily protein	Arabidopsis thaliana	97-101
16407451-8	2006	DWF4:GUS activity was increased by treatment with brassinazole, a BR biosynthetic inhibitor, and decreased by exogenous application of bioactive BRs.	brassinazole	50-62	Cytochrome P450 superfamily protein	Arabidopsis thaliana	0-4
16407451-9	2006	When DWF4:GUS was expressed in a different genetic background, its level was down-regulated in brassinazole resistant1-D, confirming that BRASSINAZOLE RESISTANT1 acts as a negative regulator of DWF4.	brassinazole	95-107	Cytochrome P450 superfamily protein	Arabidopsis thaliana	5-9
16407451-9	2006	When DWF4:GUS was expressed in a different genetic background, its level was down-regulated in brassinazole resistant1-D, confirming that BRASSINAZOLE RESISTANT1 acts as a negative regulator of DWF4.	brassinazole	95-107	Cytochrome P450 superfamily protein	Arabidopsis thaliana	194-198
16407451-9	2006	When DWF4:GUS was expressed in a different genetic background, its level was down-regulated in brassinazole resistant1-D, confirming that BRASSINAZOLE RESISTANT1 acts as a negative regulator of DWF4.	brassinazole	138-150	Cytochrome P450 superfamily protein	Arabidopsis thaliana	5-9
16407451-9	2006	When DWF4:GUS was expressed in a different genetic background, its level was down-regulated in brassinazole resistant1-D, confirming that BRASSINAZOLE RESISTANT1 acts as a negative regulator of DWF4.	brassinazole	138-150	Cytochrome P450 superfamily protein	Arabidopsis thaliana	194-198
14676973-4	2003	Investigation of target site(s) of brassinazole revealed that the compound directly binds to the DWF4 protein, a cytochrome P450 monooxygenase that catalyzes 22-hydroxylation of the side chain of BRs.	brassinazole	35-47	Cytochrome P450 superfamily protein	Arabidopsis thaliana	113-142
11319239-5	2001	DWF4, which is an Arabidopsis thaliana cytochrome P450 isolated as a putative steroid 22-hydroxylase, was expressed in Escherichia coli, and the binding affinity of brassinazole and its derivatives to the recombinant DWF4 were analyzed.	brassinazole	165-177	Cytochrome P450 superfamily protein	Arabidopsis thaliana	0-4
11319239-6	2001	Among several triazole derivatives, brassinazole had both the highest binding affinity to DWF4 and the highest growth inhibitory activity.	brassinazole	36-48	Cytochrome P450 superfamily protein	Arabidopsis thaliana	90-94
11319239-9	2001	These results indicate that brassinazole inhibits the hydroxylation of the C-22 position of the side chain in BRs by direct binding to DWF4 and that DWF4 catalyzes this hydroxylation reaction.	brassinazole	28-40	Cytochrome P450 superfamily protein	Arabidopsis thaliana	135-139
35162936-8	2022	BR receptors detect the BR at the cell surface, triggering a series of phosphorylation events that activate the central transcription factor (TF) Brassinazole-resistant 1 (BZR1), which regulates the transcription of BR-responsive genes in the nucleus.	brassinazole	146-158	chromosome 12 open reading frame 73	Homo sapiens	0-2
34618149-6	2021	bbx32 and 35S:BBX32 seedlings exhibit enhanced and reduced cotyledon opening, respectively, in response to both light and brassinazole treatment in dark, suggesting that BBX32 mediates cotyledon opening through both light and BR signaling pathways.	brassinazole	122-134	B-box 32	Arabidopsis thaliana	0-5
34618149-6	2021	bbx32 and 35S:BBX32 seedlings exhibit enhanced and reduced cotyledon opening, respectively, in response to both light and brassinazole treatment in dark, suggesting that BBX32 mediates cotyledon opening through both light and BR signaling pathways.	brassinazole	122-134	B-box 32	Arabidopsis thaliana	14-19
34618149-6	2021	bbx32 and 35S:BBX32 seedlings exhibit enhanced and reduced cotyledon opening, respectively, in response to both light and brassinazole treatment in dark, suggesting that BBX32 mediates cotyledon opening through both light and BR signaling pathways.	brassinazole	122-134	B-box 32	Arabidopsis thaliana	170-175
34618149-7	2021	BBX32 expression is induced by exogenous BR and is upregulated in bzr1-1D (BRASSINAZOLE RESISTANT1-1D).	brassinazole	75-87	B-box 32	Arabidopsis thaliana	0-5
35162936-8	2022	BR receptors detect the BR at the cell surface, triggering a series of phosphorylation events that activate the central transcription factor (TF) Brassinazole-resistant 1 (BZR1), which regulates the transcription of BR-responsive genes in the nucleus.	brassinazole	146-158	chromosome 12 open reading frame 73	Homo sapiens	24-26
33980131-2	2021	Expression of the ABA biosynthesis gene ABA-deficient 2 (ABA2) was negatively regulated by exogenously applied BR but up-regulated by the application of brassinazole and in det2 and cyp85a1 x cyp85a2.	brassinazole	153-165	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	57-61
33963401-6	2021	In addition, HBI1 or BEE2 overexpressing Arabidopsis plants are less sensitive to the BR biosynthesis inhibitor, brassinazole, and the GA biosynthesis inhibitor, paclobutrazol.	brassinazole	113-125	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	13-17
33963401-6	2021	In addition, HBI1 or BEE2 overexpressing Arabidopsis plants are less sensitive to the BR biosynthesis inhibitor, brassinazole, and the GA biosynthesis inhibitor, paclobutrazol.	brassinazole	113-125	BR enhanced expression 2	Arabidopsis thaliana	21-25
33594119-2	2021	Recently, this MBP-mediated crystallization technique was adapted to Arabidopsis thaliana (At) BRZ-INSENSITIVE-LONG (BIL1)/BRASSINAZOLE-RESISTANT (BZR1), a member of the plant-specific BZR TFs, and revealed the first structure of AtBIL1/BZR1 in complex with target DNA.	brassinazole	123-135	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	147-151
33487334-4	2021	Here we show that miR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, brassinazole (BRZ, a BR biosynthesis inhibitor), or paclobutrazol (PAC, a GA biosynthesis inhibitor)-dependent manner in Arabidopsis.	brassinazole	111-123	MIR160a	Arabidopsis thaliana	18-24
33487334-4	2021	Here we show that miR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, brassinazole (BRZ, a BR biosynthesis inhibitor), or paclobutrazol (PAC, a GA biosynthesis inhibitor)-dependent manner in Arabidopsis.	brassinazole	111-123	auxin response factor 10	Arabidopsis thaliana	46-51
33487334-4	2021	Here we show that miR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, brassinazole (BRZ, a BR biosynthesis inhibitor), or paclobutrazol (PAC, a GA biosynthesis inhibitor)-dependent manner in Arabidopsis.	brassinazole	111-123	auxin response factor 16	Arabidopsis thaliana	53-58
33487334-4	2021	Here we show that miR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, brassinazole (BRZ, a BR biosynthesis inhibitor), or paclobutrazol (PAC, a GA biosynthesis inhibitor)-dependent manner in Arabidopsis.	brassinazole	111-123	auxin response factor 17	Arabidopsis thaliana	63-68
33487334-4	2021	Here we show that miR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, brassinazole (BRZ, a BR biosynthesis inhibitor), or paclobutrazol (PAC, a GA biosynthesis inhibitor)-dependent manner in Arabidopsis.	brassinazole	125-128	MIR160a	Arabidopsis thaliana	18-24
33487334-4	2021	Here we show that miR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, brassinazole (BRZ, a BR biosynthesis inhibitor), or paclobutrazol (PAC, a GA biosynthesis inhibitor)-dependent manner in Arabidopsis.	brassinazole	125-128	auxin response factor 10	Arabidopsis thaliana	46-51
33487334-4	2021	Here we show that miR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, brassinazole (BRZ, a BR biosynthesis inhibitor), or paclobutrazol (PAC, a GA biosynthesis inhibitor)-dependent manner in Arabidopsis.	brassinazole	125-128	auxin response factor 16	Arabidopsis thaliana	53-58
33487334-4	2021	Here we show that miR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, brassinazole (BRZ, a BR biosynthesis inhibitor), or paclobutrazol (PAC, a GA biosynthesis inhibitor)-dependent manner in Arabidopsis.	brassinazole	125-128	auxin response factor 17	Arabidopsis thaliana	63-68
33280146-1	2021	The BRASSINAZOLE-RESISTANT 1 (BZR1) transcription factor family plays an essential role in plant brassinosteroid (BR) signaling, but the signaling mechanism through which BZR1 and its homologs cooperate with certain coactivators to facilitate transcription of target genes remains incompletely understood.	brassinazole	4-16	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	30-34
33280146-1	2021	The BRASSINAZOLE-RESISTANT 1 (BZR1) transcription factor family plays an essential role in plant brassinosteroid (BR) signaling, but the signaling mechanism through which BZR1 and its homologs cooperate with certain coactivators to facilitate transcription of target genes remains incompletely understood.	brassinazole	4-16	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	171-175
32005383-3	2020	BRASSINAZOLE RESISTANT 1 (BZR1) is one of important transcription factors that regulate organ size in BR signal pathway in Arabidopsis.	brassinazole	0-12	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	26-30
32570783-2	2020	The BR signals are perceived by two cell surface-localized receptor kinases, Brassinosteroid-Insensitive1 (BRI1) and BRI1-Associated receptor Kinase (BAK1), and reach the nucleus through two master transcription factors, bri1-EMS suppressor1 (BES1) and Brassinazole-resistant1 (BZR1).	brassinazole	253-265	BCL2 antagonist/killer 1	Homo sapiens	150-154
32028614-1	2020	The BRI1-EMS suppressor 1 (BES1)/brassinazole-resistant 1 (BZR1) transcription factors, key components in the brassinosteroid signaling pathway, play pivotal roles in plant growth and development.	brassinazole	33-45	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	4-25
32028614-1	2020	The BRI1-EMS suppressor 1 (BES1)/brassinazole-resistant 1 (BZR1) transcription factors, key components in the brassinosteroid signaling pathway, play pivotal roles in plant growth and development.	brassinazole	33-45	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	59-63
30920691-1	2019	Oryza sativa BRASSINAZOLE RESISTANT 1 (OsBZR1) is the closest rice homolog of the Arabidopsis BZR1 and bri1-EMS-SUPPRESSOR 1 (BES1)/BZR2 transcription factors.	brassinazole	13-25	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	103-124
31357236-9	2019	RD26 overexpression suppressed the brassinazole (BRZ)  insensitivity of BIN2 triple mutant bin2 bil1 bil2, and BIN2 function is required for the drought tolerance of RD26 overexpression plants.	brassinazole	35-47	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	0-4
31357236-9	2019	RD26 overexpression suppressed the brassinazole (BRZ)  insensitivity of BIN2 triple mutant bin2 bil1 bil2, and BIN2 function is required for the drought tolerance of RD26 overexpression plants.	brassinazole	49-52	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	0-4
31290980-4	2019	T-DNA insertion mutant siz1-2 shows BL (Brassinolide, the most active BR) hypersensitivity and BRZ (Brassinazole, a BR biosynthesis inhibitor) insensitivity during hypocotyl elongation.	brassinazole	95-98	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	23-29
31290980-4	2019	T-DNA insertion mutant siz1-2 shows BL (Brassinolide, the most active BR) hypersensitivity and BRZ (Brassinazole, a BR biosynthesis inhibitor) insensitivity during hypocotyl elongation.	brassinazole	100-112	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	23-29
31189737-6	2019	TTL3 directly interacts with a constitutively active BRASSINOSTEROID INSENSITIVE1 (BRI1) receptor kinase, BRI1-SUPPRESSOR1 phosphatase, and the BRASSINAZOLE RESISTANT1 transcription factor and associates with BR-SIGNALING KINASE1, BRASSINOSTEROID INSENSITIVE2 kinases, but not with BRI1-ASSOCIATED KINASE1.	brassinazole	144-156	tetratricopetide-repeat thioredoxin-like 3	Arabidopsis thaliana	0-4
31189657-3	2019	Here, we demonstrate that tomato (Solanum lycopersicum) mutants of brassinosteroid (BR) biosynthesis (dwf) and related signaling through BRASSINAZOLE-RESISTANT1 (bzr1) are more sensitive to (PSII and PSI photoinhibition, with decreased cyclic electron flow around PSI and lower nonphotochemical quenching, accumulation of PSII subunit S (PsbS), violaxanthin deepoxidase (VDE) activity, and D1 protein abundance.	brassinazole	137-149	photosystem II subunit S	Solanum lycopersicum	322-336
31189657-3	2019	Here, we demonstrate that tomato (Solanum lycopersicum) mutants of brassinosteroid (BR) biosynthesis (dwf) and related signaling through BRASSINAZOLE-RESISTANT1 (bzr1) are more sensitive to (PSII and PSI photoinhibition, with decreased cyclic electron flow around PSI and lower nonphotochemical quenching, accumulation of PSII subunit S (PsbS), violaxanthin deepoxidase (VDE) activity, and D1 protein abundance.	brassinazole	137-149	photosystem II subunit S	Solanum lycopersicum	338-342
31189657-3	2019	Here, we demonstrate that tomato (Solanum lycopersicum) mutants of brassinosteroid (BR) biosynthesis (dwf) and related signaling through BRASSINAZOLE-RESISTANT1 (bzr1) are more sensitive to (PSII and PSI photoinhibition, with decreased cyclic electron flow around PSI and lower nonphotochemical quenching, accumulation of PSII subunit S (PsbS), violaxanthin deepoxidase (VDE) activity, and D1 protein abundance.	brassinazole	137-149	violaxanthin de-epoxidase	Solanum lycopersicum	371-374
31156660-7	2019	MSBP1 overexpression could be mimicked by brassinazole treatment.	brassinazole	42-54	membrane steroid binding protein 1	Arabidopsis thaliana	0-5
30814258-1	2019	Brassinosteroid (BR) regulates a wide range of physiological responses through the activation of BRASSINAZOLE RESISTANT1 (BZR1), whose activity is tightly controlled by its phosphorylation status and degradation.	brassinazole	97-109	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	122-126
31013593-4	2019	Exogenous 2,4-epibrassinolide (BL) or brassinazole (BRZ) applications indicated that BR pathway was involved in the susceptibility to MCMV infection.	brassinazole	38-50	chromosome 12 open reading frame 73	Homo sapiens	52-54
29375601-4	2017	An AGB1-null mutant, agb1-2, displays BR hyposensitivity and brassinazole (BRZ, BR biosynthesis inhibitor) hypersensitivity, which suggests that AGB1 positively mediates the BR signaling pathway.	brassinazole	61-73	GTP binding protein beta 1	Arabidopsis thaliana	3-7
29375601-4	2017	An AGB1-null mutant, agb1-2, displays BR hyposensitivity and brassinazole (BRZ, BR biosynthesis inhibitor) hypersensitivity, which suggests that AGB1 positively mediates the BR signaling pathway.	brassinazole	61-73	GTP binding protein beta 1	Arabidopsis thaliana	21-25
29375601-4	2017	An AGB1-null mutant, agb1-2, displays BR hyposensitivity and brassinazole (BRZ, BR biosynthesis inhibitor) hypersensitivity, which suggests that AGB1 positively mediates the BR signaling pathway.	brassinazole	61-73	GTP binding protein beta 1	Arabidopsis thaliana	145-149
29375601-4	2017	An AGB1-null mutant, agb1-2, displays BR hyposensitivity and brassinazole (BRZ, BR biosynthesis inhibitor) hypersensitivity, which suggests that AGB1 positively mediates the BR signaling pathway.	brassinazole	75-78	GTP binding protein beta 1	Arabidopsis thaliana	3-7
29375601-4	2017	An AGB1-null mutant, agb1-2, displays BR hyposensitivity and brassinazole (BRZ, BR biosynthesis inhibitor) hypersensitivity, which suggests that AGB1 positively mediates the BR signaling pathway.	brassinazole	75-78	GTP binding protein beta 1	Arabidopsis thaliana	21-25
29375601-4	2017	An AGB1-null mutant, agb1-2, displays BR hyposensitivity and brassinazole (BRZ, BR biosynthesis inhibitor) hypersensitivity, which suggests that AGB1 positively mediates the BR signaling pathway.	brassinazole	75-78	GTP binding protein beta 1	Arabidopsis thaliana	145-149
28720789-2	2017	To investigate the mechanisms of BR signaling, we previously used the BR biosynthesis inhibitor Brz as a chemical biology tool and identified the Brz-insensitive-long hypocotyl4 mutant (bil4).	brassinazole	96-99	Bax inhibitor-1 family protein	Arabidopsis thaliana	186-190
28720789-2	2017	To investigate the mechanisms of BR signaling, we previously used the BR biosynthesis inhibitor Brz as a chemical biology tool and identified the Brz-insensitive-long hypocotyl4 mutant (bil4).	brassinazole	146-149	Bax inhibitor-1 family protein	Arabidopsis thaliana	186-190
25998528-1	2015	MAIN CONCLUSION: Brassinosteroid is necessary for sugar promotion of Arabidopsis hypocotyl elongation in darkness, and sugar positively regulates BRASSINAZOLE RESISTANT1 (BZR1) at both transcription and protein levels.	brassinazole	146-158	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	171-175
26493403-8	2015	The photomorphogenic phenotypes of ATAF2 loss- and gain-of-function seedlings are suppressed by treatment with the BR biosynthesis inhibitor brassinazole.	brassinazole	141-153	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	35-40
25998528-5	2015	Sugar also up-regulated the expression of genes that are related to cell elongation in a BR-dependent manner, and this effect was more remarkable in bzr1-1D and bes1-D than in their corresponding wild types in the presence of BRZ, suggesting an important role of BZR1 and bri1-ems-suppressor 1 (BES1) in this process.	brassinazole	226-229	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	149-153
25998528-5	2015	Sugar also up-regulated the expression of genes that are related to cell elongation in a BR-dependent manner, and this effect was more remarkable in bzr1-1D and bes1-D than in their corresponding wild types in the presence of BRZ, suggesting an important role of BZR1 and bri1-ems-suppressor 1 (BES1) in this process.	brassinazole	226-229	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	161-165
26113159-6	2015	The mRNA levels of genes encoding sucrose metabolic invertase (VvcwINV), and monosaccharide (VvHT3, 4, 5 and 6) and disaccharide (VvSUC12 and 27) transporters were increased by the EBR and/or Brz + EBR treatments.	brassinazole	192-195	hexose transporter 7	Vitis vinifera	93-110
24443525-9	2014	Also, HBI1-overexpressing plants are hyperresponsive to BR and more resistant to the BR biosynthetic inhibitor brassinazole.	brassinazole	111-123	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	6-10
25793645-3	2015	Brassinazole is a specific inhibitor of C-22 hydroxylase (CYP90B1) in BR biosynthesis, and the application use of brassinazole has emerged as an effective way of complementing BR-deficient mutants to elucidate the functions of BRs.	brassinazole	0-12	Cytochrome P450 superfamily protein	Arabidopsis thaliana	58-65
25793645-3	2015	Brassinazole is a specific inhibitor of C-22 hydroxylase (CYP90B1) in BR biosynthesis, and the application use of brassinazole has emerged as an effective way of complementing BR-deficient mutants to elucidate the functions of BRs.	brassinazole	114-126	Cytochrome P450 superfamily protein	Arabidopsis thaliana	58-65
25036828-3	2014	We identify here the dominant mutant Brz-insensitive-pale green3-1D (bpg3-1D) from the Arabidopsis FOX lines that show reduced sensitivity to the chlorophyll accumulation promoted by the BR biosynthesis inhibitor, Brassinazole (Brz), in the light.	brassinazole	214-226	DUF399 family protein, putative (DUF399 and DUF3411)	Arabidopsis thaliana	69-73
25036828-3	2014	We identify here the dominant mutant Brz-insensitive-pale green3-1D (bpg3-1D) from the Arabidopsis FOX lines that show reduced sensitivity to the chlorophyll accumulation promoted by the BR biosynthesis inhibitor, Brassinazole (Brz), in the light.	brassinazole	37-40	DUF399 family protein, putative (DUF399 and DUF3411)	Arabidopsis thaliana	69-73
23083315-9	2013	Inhibition of brassinosteroid (BR) biosynthesis with brassinazole (BZ) caused a loss of responsiveness to PSK in wild-type, tpst-1 (tyrosylprotein sulfotransferase-1), PSKR1ox12 and CER6:PSKR1-3-1 seedlings, as did the genetic knock-out of BR synthesis in det2-1 and of BR perception in bri1-9, suggesting that BR mediates PSK-dependent growth.	brassinazole	53-65	3-ketoacyl-CoA synthase 6	Arabidopsis thaliana	182-186
24102834-1	2014	The brassinosteroid (BR) response transcription factor Brassinazole resistant 1 (BZR1)-mediated BR signalling regulates many specific developmental processes including fruit ripening.	brassinazole	55-67	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	81-85
23814276-4	2013	Expression of bzr1-1 alleviated the effects of a BR biosynthesis inhibitor, brassinazole, in both the wild type and agb1-1, and overexpression of BZR1 alleviated the effects of ABA in both the wild type and agb1-1.	brassinazole	76-88	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	14-18
23814276-4	2013	Expression of bzr1-1 alleviated the effects of a BR biosynthesis inhibitor, brassinazole, in both the wild type and agb1-1, and overexpression of BZR1 alleviated the effects of ABA in both the wild type and agb1-1.	brassinazole	76-88	GTP binding protein beta 1	Arabidopsis thaliana	116-122
23083315-9	2013	Inhibition of brassinosteroid (BR) biosynthesis with brassinazole (BZ) caused a loss of responsiveness to PSK in wild-type, tpst-1 (tyrosylprotein sulfotransferase-1), PSKR1ox12 and CER6:PSKR1-3-1 seedlings, as did the genetic knock-out of BR synthesis in det2-1 and of BR perception in bri1-9, suggesting that BR mediates PSK-dependent growth.	brassinazole	53-65	phytosulfokin receptor 1	Arabidopsis thaliana	168-173
23083315-9	2013	Inhibition of brassinosteroid (BR) biosynthesis with brassinazole (BZ) caused a loss of responsiveness to PSK in wild-type, tpst-1 (tyrosylprotein sulfotransferase-1), PSKR1ox12 and CER6:PSKR1-3-1 seedlings, as did the genetic knock-out of BR synthesis in det2-1 and of BR perception in bri1-9, suggesting that BR mediates PSK-dependent growth.	brassinazole	53-65	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	287-293
23083315-9	2013	Inhibition of brassinosteroid (BR) biosynthesis with brassinazole (BZ) caused a loss of responsiveness to PSK in wild-type, tpst-1 (tyrosylprotein sulfotransferase-1), PSKR1ox12 and CER6:PSKR1-3-1 seedlings, as did the genetic knock-out of BR synthesis in det2-1 and of BR perception in bri1-9, suggesting that BR mediates PSK-dependent growth.	brassinazole	67-69	3-ketoacyl-CoA synthase 6	Arabidopsis thaliana	182-186
23083315-9	2013	Inhibition of brassinosteroid (BR) biosynthesis with brassinazole (BZ) caused a loss of responsiveness to PSK in wild-type, tpst-1 (tyrosylprotein sulfotransferase-1), PSKR1ox12 and CER6:PSKR1-3-1 seedlings, as did the genetic knock-out of BR synthesis in det2-1 and of BR perception in bri1-9, suggesting that BR mediates PSK-dependent growth.	brassinazole	67-69	phytosulfokin receptor 1	Arabidopsis thaliana	168-173
23083315-9	2013	Inhibition of brassinosteroid (BR) biosynthesis with brassinazole (BZ) caused a loss of responsiveness to PSK in wild-type, tpst-1 (tyrosylprotein sulfotransferase-1), PSKR1ox12 and CER6:PSKR1-3-1 seedlings, as did the genetic knock-out of BR synthesis in det2-1 and of BR perception in bri1-9, suggesting that BR mediates PSK-dependent growth.	brassinazole	67-69	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	287-293
23169658-3	2012	BRs signal through plasma membrane-localized receptor kinase brassinosteroid-insensitive 1 (BRI1), BRI1-associated receptor kinase (BAK1), and several intermediates to regulate the protein levels, cellular localizations, and/or DNA binding of BRI1-EMS suppressor 1 (BES1)/brassinazole-resistant 1 (BZR1) family transcription factors.	brassinazole	272-284	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	243-264
22920123-5	2012	It was found that the XY = LiF interaction causes the greatest distortion of the H(3)N/HCN...BrZ halogen bond from the preferred linear orientation and also provides the strongest binding energy via the nonadditive energy.	brassinazole	93-96	LIF interleukin 6 family cytokine	Homo sapiens	27-30
23115248-6	2012	Brassinazole-resistant1, a key transcription factor in the BR signaling pathway, directly targets and upregulates MDP40.	brassinazole	0-12	hypothetical protein	Arabidopsis thaliana	114-119
22920123-5	2012	It was found that the XY = LiF interaction causes the greatest distortion of the H(3)N/HCN...BrZ halogen bond from the preferred linear orientation and also provides the strongest binding energy via the nonadditive energy.	brassinazole	93-96	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	87-90
20396969-8	2010	In addition, the ARF8 gene expression was significantly reduced by BR but induced by brassinazole, a BR biosynthetic inhibitor.	brassinazole	85-97	auxin response factor 8	Arabidopsis thaliana	17-21
21487098-2	2011	They possess BRASSINAZOLE RESISTANT1 (BZR1)-type DNA binding domains--also found in transcription factors mediating brassinosteroid (BR) responses.	brassinazole	13-25	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	38-42
21909364-3	2011	Semi-quantitative reverse-transcriptase PCR showed that the amount of the DWF4 mRNA precursor either decreased or increased, similarly with its mature form, in response to an exogenously applied bioactive BR, brassinolide (BL), and a BR biosynthesis inhibitor, brassinazole (Brz), respectively.	brassinazole	261-273	Cytochrome P450 superfamily protein	Arabidopsis thaliana	74-78
21909364-3	2011	Semi-quantitative reverse-transcriptase PCR showed that the amount of the DWF4 mRNA precursor either decreased or increased, similarly with its mature form, in response to an exogenously applied bioactive BR, brassinolide (BL), and a BR biosynthesis inhibitor, brassinazole (Brz), respectively.	brassinazole	275-278	Cytochrome P450 superfamily protein	Arabidopsis thaliana	74-78
20522560-3	2010	Brassinosteroid-INsensitive 2 (BIN2) is an Arabidopsis GSK3-like kinase that negatively regulates brassinosteroid (BR) signaling by phosphorylating BES1 (bri1 EMS suppressor 1) and BZR1 (brassinazole-resistant 1), two highly similar transcription factors critical for bringing about characteristic BR responses.	brassinazole	187-199	Protein kinase superfamily protein	Arabidopsis thaliana	0-29
20522560-3	2010	Brassinosteroid-INsensitive 2 (BIN2) is an Arabidopsis GSK3-like kinase that negatively regulates brassinosteroid (BR) signaling by phosphorylating BES1 (bri1 EMS suppressor 1) and BZR1 (brassinazole-resistant 1), two highly similar transcription factors critical for bringing about characteristic BR responses.	brassinazole	187-199	Protein kinase superfamily protein	Arabidopsis thaliana	31-35
20522560-3	2010	Brassinosteroid-INsensitive 2 (BIN2) is an Arabidopsis GSK3-like kinase that negatively regulates brassinosteroid (BR) signaling by phosphorylating BES1 (bri1 EMS suppressor 1) and BZR1 (brassinazole-resistant 1), two highly similar transcription factors critical for bringing about characteristic BR responses.	brassinazole	187-199	shaggy	Drosophila melanogaster	55-59
20522560-3	2010	Brassinosteroid-INsensitive 2 (BIN2) is an Arabidopsis GSK3-like kinase that negatively regulates brassinosteroid (BR) signaling by phosphorylating BES1 (bri1 EMS suppressor 1) and BZR1 (brassinazole-resistant 1), two highly similar transcription factors critical for bringing about characteristic BR responses.	brassinazole	187-199	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	154-175
20522560-3	2010	Brassinosteroid-INsensitive 2 (BIN2) is an Arabidopsis GSK3-like kinase that negatively regulates brassinosteroid (BR) signaling by phosphorylating BES1 (bri1 EMS suppressor 1) and BZR1 (brassinazole-resistant 1), two highly similar transcription factors critical for bringing about characteristic BR responses.	brassinazole	187-199	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	181-185
20108170-8	2010	Furthermore, the sensitivity of transgenic plants overexpressing BAK7 to brassinazole, a biosynthetic inhibitor of brassinolide (BL), did not change compared to that of wild-type plants.	brassinazole	73-85	somatic embryogenesis receptor-like kinase 4	Arabidopsis thaliana	65-69
20387034-1	2010	Brassinosteroids BRs)play important roles in plant growth and development.BRs modulate the phosphorylation status of two crucial transcription factors, BRI1 EMS SUPPRESSOR1 BES1)and BRASSINAZOLE RESISTANT1 (BZR1).Here we show that BES1 functions as a nucleocytoplasmic signal transmitter, and that its subcellular localization modulates the output intensity of the BR signal.BRASSINOSTEROID INSENSITIVE2 (BIN2)and other group II GLYCOGEN SYNTHASE KINASE 3 GSK3)-like kinases phosphorylate BES1 and induce its nuclear export by regulating its binding affinity with 14-3-3 proteins.We identified twelve putative phosphorylation residues in BES1.Two of these residues, Ser 171 and Thr 175, are critical for interaction with 14-3-3 proteins.The other putative phosphorylation sites in the N-terminal region are required for the BIN2-mediated nuclear export of BES1.Mutations of these motifs result in increased nuclear accumulation of BES1 and enhanced BR responses in transgenic plants.Taken together, our results indicate that the spatial redistribution of BES1 is important for regulation of the BR signaling output.	brassinazole	182-194	bridging integrator 2	Homo sapiens	405-409
20387034-1	2010	Brassinosteroids BRs)play important roles in plant growth and development.BRs modulate the phosphorylation status of two crucial transcription factors, BRI1 EMS SUPPRESSOR1 BES1)and BRASSINAZOLE RESISTANT1 (BZR1).Here we show that BES1 functions as a nucleocytoplasmic signal transmitter, and that its subcellular localization modulates the output intensity of the BR signal.BRASSINOSTEROID INSENSITIVE2 (BIN2)and other group II GLYCOGEN SYNTHASE KINASE 3 GSK3)-like kinases phosphorylate BES1 and induce its nuclear export by regulating its binding affinity with 14-3-3 proteins.We identified twelve putative phosphorylation residues in BES1.Two of these residues, Ser 171 and Thr 175, are critical for interaction with 14-3-3 proteins.The other putative phosphorylation sites in the N-terminal region are required for the BIN2-mediated nuclear export of BES1.Mutations of these motifs result in increased nuclear accumulation of BES1 and enhanced BR responses in transgenic plants.Taken together, our results indicate that the spatial redistribution of BES1 is important for regulation of the BR signaling output.	brassinazole	182-194	bridging integrator 2	Homo sapiens	824-828
20387035-1	2010	During brassinosteroid (BR) signaling in Arabidopsis, BSU1 (bri1 SUPPRESSOR1) phosphatase and BIN2 (BRASSINOSTEROID INSENSITIVE2) kinase regulate the signal intensity by determining the phosphorylation status of the transcription factors BZR1 (BRASSINAZOLE RESISTANT1) and BES1 (bri1 EMS SUPPRESSOR1).	brassinazole	244-256	Serine/threonine protein phosphatase family protein	Arabidopsis thaliana	54-58
20387035-1	2010	During brassinosteroid (BR) signaling in Arabidopsis, BSU1 (bri1 SUPPRESSOR1) phosphatase and BIN2 (BRASSINOSTEROID INSENSITIVE2) kinase regulate the signal intensity by determining the phosphorylation status of the transcription factors BZR1 (BRASSINAZOLE RESISTANT1) and BES1 (bri1 EMS SUPPRESSOR1).	brassinazole	244-256	Serine/threonine protein phosphatase family protein	Arabidopsis thaliana	60-76
20387035-1	2010	During brassinosteroid (BR) signaling in Arabidopsis, BSU1 (bri1 SUPPRESSOR1) phosphatase and BIN2 (BRASSINOSTEROID INSENSITIVE2) kinase regulate the signal intensity by determining the phosphorylation status of the transcription factors BZR1 (BRASSINAZOLE RESISTANT1) and BES1 (bri1 EMS SUPPRESSOR1).	brassinazole	244-256	Protein kinase superfamily protein	Arabidopsis thaliana	94-98
20387035-1	2010	During brassinosteroid (BR) signaling in Arabidopsis, BSU1 (bri1 SUPPRESSOR1) phosphatase and BIN2 (BRASSINOSTEROID INSENSITIVE2) kinase regulate the signal intensity by determining the phosphorylation status of the transcription factors BZR1 (BRASSINAZOLE RESISTANT1) and BES1 (bri1 EMS SUPPRESSOR1).	brassinazole	244-256	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	238-242
20387035-1	2010	During brassinosteroid (BR) signaling in Arabidopsis, BSU1 (bri1 SUPPRESSOR1) phosphatase and BIN2 (BRASSINOSTEROID INSENSITIVE2) kinase regulate the signal intensity by determining the phosphorylation status of the transcription factors BZR1 (BRASSINAZOLE RESISTANT1) and BES1 (bri1 EMS SUPPRESSOR1).	brassinazole	244-256	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	273-277
20387035-1	2010	During brassinosteroid (BR) signaling in Arabidopsis, BSU1 (bri1 SUPPRESSOR1) phosphatase and BIN2 (BRASSINOSTEROID INSENSITIVE2) kinase regulate the signal intensity by determining the phosphorylation status of the transcription factors BZR1 (BRASSINAZOLE RESISTANT1) and BES1 (bri1 EMS SUPPRESSOR1).	brassinazole	244-256	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	279-299
20035956-8	2010	In addition, the brassinazole resistance of bzr1-1D was impaired in the double mutant.	brassinazole	17-29	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	44-48
19919572-8	2010	Chloroplast protein accumulation induced by Brz was suppressed by the bpg2 mutation.	brassinazole	44-47	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	70-74
19170933-3	2009	BRs signal through the BES1/BZR1 (bri1-Ethylmethane Sulphonate suppressor 1/brassinazole-resistant 1) family of transcription factors, which regulate hundreds of target genes involved in this pathway, yet little is known of this transcriptional network.	brassinazole	76-88	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	23-27
19170933-3	2009	BRs signal through the BES1/BZR1 (bri1-Ethylmethane Sulphonate suppressor 1/brassinazole-resistant 1) family of transcription factors, which regulate hundreds of target genes involved in this pathway, yet little is known of this transcriptional network.	brassinazole	76-88	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	28-32
19170933-3	2009	BRs signal through the BES1/BZR1 (bri1-Ethylmethane Sulphonate suppressor 1/brassinazole-resistant 1) family of transcription factors, which regulate hundreds of target genes involved in this pathway, yet little is known of this transcriptional network.	brassinazole	76-88	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	34-38
17470144-4	2007	Interestingly, IAA treatment to the roots of bri1-301 and bak1 plants or of plants pretreated with a BL biosynthetic inhibitor, brassinazole, increased their sensitivity to gravity, while these treatments for the BL-hypersensitive transgenic plants, BRI1-GFP and 35S-BAK1, were less effective.	brassinazole	128-140	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	250-254