PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 20967297-1 2010 Ulipristal acetate is a progesterone receptor modulator. ulipristal acetate 0-18 progesterone receptor Homo sapiens 24-45 20967297-3 2010 Ulipristal acetate acts as an antagonist of the progesterone receptor at the transcriptional level and a competitive antagonist of glucocorticoid receptor function. ulipristal acetate 0-18 progesterone receptor Homo sapiens 48-69 20967297-3 2010 Ulipristal acetate acts as an antagonist of the progesterone receptor at the transcriptional level and a competitive antagonist of glucocorticoid receptor function. ulipristal acetate 0-18 nuclear receptor subfamily 3 group C member 1 Homo sapiens 131-154 35424854-3 2022 In this study, four binary amorphous mixtures of ulipristal acetate (UPA) with CDs (beta-CD, gamma-CD, dimethyl-beta-CD, hydroxypropyl-beta-CD) were prepared by the co-milling method and characterized in the solid-state. ulipristal acetate 49-67 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 84-91 34442082-1 2021 To prevent unwanted pregnancies, oral emergency contraception (EC) with the active ingredients levonorgestrel (LNG) and ulipristal acetate (UPA) is recommended by the guidelines of the German Federal Chamber of Pharmacists (BAK). ulipristal acetate 120-138 BCL2 antagonist/killer 1 Homo sapiens 224-227 34442082-1 2021 To prevent unwanted pregnancies, oral emergency contraception (EC) with the active ingredients levonorgestrel (LNG) and ulipristal acetate (UPA) is recommended by the guidelines of the German Federal Chamber of Pharmacists (BAK). ulipristal acetate 140-143 BCL2 antagonist/killer 1 Homo sapiens 224-227 35424854-3 2022 In this study, four binary amorphous mixtures of ulipristal acetate (UPA) with CDs (beta-CD, gamma-CD, dimethyl-beta-CD, hydroxypropyl-beta-CD) were prepared by the co-milling method and characterized in the solid-state. ulipristal acetate 49-67 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 112-119 35424854-3 2022 In this study, four binary amorphous mixtures of ulipristal acetate (UPA) with CDs (beta-CD, gamma-CD, dimethyl-beta-CD, hydroxypropyl-beta-CD) were prepared by the co-milling method and characterized in the solid-state. ulipristal acetate 49-67 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 135-142 32647996-1 2020 INTRODUCTION: Ulipristal acetate (ulipristal) is a selective progesterone receptor modulator that has been marketed for daily use in Europe and Canada to reduce symptoms caused by uterine fibroids. ulipristal acetate 14-32 progesterone receptor Homo sapiens 61-82 33893356-7 2021 In addition, co-treatment with metformin and UPA was associated with significant increase in the Bax and significant reduction in Bcl-2, PCNA, Cyclin-D1and ER-alpha as compared to treatment with UPA alone. ulipristal acetate 45-48 BCL2 associated X, apoptosis regulator Rattus norvegicus 97-100 33893356-7 2021 In addition, co-treatment with metformin and UPA was associated with significant increase in the Bax and significant reduction in Bcl-2, PCNA, Cyclin-D1and ER-alpha as compared to treatment with UPA alone. ulipristal acetate 45-48 BCL2, apoptosis regulator Rattus norvegicus 130-135 33893356-7 2021 In addition, co-treatment with metformin and UPA was associated with significant increase in the Bax and significant reduction in Bcl-2, PCNA, Cyclin-D1and ER-alpha as compared to treatment with UPA alone. ulipristal acetate 45-48 proliferating cell nuclear antigen Rattus norvegicus 137-141 33893356-7 2021 In addition, co-treatment with metformin and UPA was associated with significant increase in the Bax and significant reduction in Bcl-2, PCNA, Cyclin-D1and ER-alpha as compared to treatment with UPA alone. ulipristal acetate 45-48 cyclin D1 Rattus norvegicus 143-152 33893356-7 2021 In addition, co-treatment with metformin and UPA was associated with significant increase in the Bax and significant reduction in Bcl-2, PCNA, Cyclin-D1and ER-alpha as compared to treatment with UPA alone. ulipristal acetate 45-48 estrogen receptor 1 Rattus norvegicus 156-164 33893356-10 2021 In conclusion, UPA-induced PAECs are associated with altered expression of genes involved in cell proliferation, apoptosis, estrogen receptor, glucose metabolism and lipid metabolism. ulipristal acetate 15-18 estrogen receptor 1 Rattus norvegicus 124-141 32813881-1 2021 The emergency contraceptives drugs (EC) levonorgestrel (LNG) and ulipristal acetate (UPA) are sensitive substrate of cytochrome P450 3A4 (CYP3A4). ulipristal acetate 65-83 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 117-136 32813881-1 2021 The emergency contraceptives drugs (EC) levonorgestrel (LNG) and ulipristal acetate (UPA) are sensitive substrate of cytochrome P450 3A4 (CYP3A4). ulipristal acetate 65-83 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 138-144 32813881-1 2021 The emergency contraceptives drugs (EC) levonorgestrel (LNG) and ulipristal acetate (UPA) are sensitive substrate of cytochrome P450 3A4 (CYP3A4). ulipristal acetate 85-88 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 117-136 32813881-1 2021 The emergency contraceptives drugs (EC) levonorgestrel (LNG) and ulipristal acetate (UPA) are sensitive substrate of cytochrome P450 3A4 (CYP3A4). ulipristal acetate 85-88 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 138-144 32322890-1 2020 STUDY QUESTION: Is the failure of the selective progesterone receptor modulator ulipristal acetate (UPA) as emergency contraception (EC; 30 mg, single) or inadvertent exposure for myoma treatment (5 mg/d) in pregnancy associated with a higher risk of birth defects, spontaneous abortion (SAB) or elective termination of pregnancy (ETOP)? ulipristal acetate 80-98 progesterone receptor Homo sapiens 48-69 31987017-10 2020 The UPA administration reduced cofilin, Erk and Src phosphorylation, p27 and ezrin protein levels, but not Akt phosphorylation and cyclin D1 and beta-catenin levels. ulipristal acetate 4-7 mitogen-activated protein kinase 1 Homo sapiens 40-43 30702466-1 2020 Ulipristal acetate is a selective progesterone receptor modulator that acts on progesterone receptors in uterine muscle and endometrium. ulipristal acetate 0-18 progesterone receptor Homo sapiens 34-55 32012826-1 2020 Background: Selective progesterone receptor modulator ulipristal acetate (UPA) is a drug used in management of symptomatic myomas. ulipristal acetate 54-72 progesterone receptor Homo sapiens 22-43 32012826-1 2020 Background: Selective progesterone receptor modulator ulipristal acetate (UPA) is a drug used in management of symptomatic myomas. ulipristal acetate 74-77 progesterone receptor Homo sapiens 22-43 31987017-10 2020 The UPA administration reduced cofilin, Erk and Src phosphorylation, p27 and ezrin protein levels, but not Akt phosphorylation and cyclin D1 and beta-catenin levels. ulipristal acetate 4-7 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 48-51 31987017-10 2020 The UPA administration reduced cofilin, Erk and Src phosphorylation, p27 and ezrin protein levels, but not Akt phosphorylation and cyclin D1 and beta-catenin levels. ulipristal acetate 4-7 dynactin subunit 6 Homo sapiens 69-72 31987017-10 2020 The UPA administration reduced cofilin, Erk and Src phosphorylation, p27 and ezrin protein levels, but not Akt phosphorylation and cyclin D1 and beta-catenin levels. ulipristal acetate 4-7 ezrin Homo sapiens 77-82 30056779-1 2019 Interaction between ulipristal acetate (UPA) and human serum albumin (HSA) was investigated in simulated physiological environment using multi-spectroscopic and computational methods. ulipristal acetate 20-38 albumin Homo sapiens 55-68 31843092-8 2019 RESULT(S): The increase of LC3-II protein, LC3-II:LC3-I ratio, and p62/SQSTM1 protein indicates that UPA treatment up-regulates the autophagic response in leiomyoma cells, whereas these markers were almost unchanged in myometrial cells. ulipristal acetate 101-104 microtubule associated protein 1 light chain 3 alpha Homo sapiens 27-30 31843092-8 2019 RESULT(S): The increase of LC3-II protein, LC3-II:LC3-I ratio, and p62/SQSTM1 protein indicates that UPA treatment up-regulates the autophagic response in leiomyoma cells, whereas these markers were almost unchanged in myometrial cells. ulipristal acetate 101-104 sequestosome 1 Homo sapiens 67-70 31843092-8 2019 RESULT(S): The increase of LC3-II protein, LC3-II:LC3-I ratio, and p62/SQSTM1 protein indicates that UPA treatment up-regulates the autophagic response in leiomyoma cells, whereas these markers were almost unchanged in myometrial cells. ulipristal acetate 101-104 sequestosome 1 Homo sapiens 71-77 31843092-9 2019 Consistently, an increased level of Atg7 and Atg4D proteins was observed only in UPA-treated leiomyoma cells. ulipristal acetate 81-84 autophagy related 7 Homo sapiens 36-40 31843092-9 2019 Consistently, an increased level of Atg7 and Atg4D proteins was observed only in UPA-treated leiomyoma cells. ulipristal acetate 81-84 autophagy related 4D cysteine peptidase Homo sapiens 45-50 30239831-2 2019 Ulipristal acetate, a selective progesterone receptor (PR) modulator, significantly reduces fibroid size in patients. ulipristal acetate 0-18 progesterone receptor Homo sapiens 55-57 30239831-6 2019 Methods and Results: Fibroid samples from patients treated with ulipristal acetate or placebo were examined for AKAP13 expression by using immunohistochemistry. ulipristal acetate 64-82 A-kinase anchoring protein 13 Homo sapiens 112-118 30871768-0 2019 Ulipristal acetate decreases active TGF-beta3 and its canonical signaling in uterine leiomyoma via two novel mechanisms. ulipristal acetate 0-18 transforming growth factor beta 3 Homo sapiens 36-45 30239831-2 2019 Ulipristal acetate, a selective progesterone receptor (PR) modulator, significantly reduces fibroid size in patients. ulipristal acetate 0-18 progesterone receptor Homo sapiens 32-53 29227976-1 2018 OBJECTIVE: To investigate whether ulipristal acetate (UPA) treatment modifies the expression of progesterone receptor (PR), its nuclear cofactors steroid receptor coactivator-1 (SRC1) and nuclear corepressor-1 (NCoR1), prosurvival factor B-cell lymphoma 2 (Bcl-2), and Akt in uterine myomas. ulipristal acetate 34-52 progesterone receptor Homo sapiens 96-117 30656992-7 2019 UPA-ECPs: literature: EllaOne prevents ovulation only when is taken in the first fertile day. ulipristal acetate 22-29 proline rich acidic protein 1 Homo sapiens 0-3 30567472-0 2019 Ulipristal Acetate Mediates Decreased Proteoglycan Expression Through Regulation of Nuclear Factor of Activated T-Cells (NFAT5). ulipristal acetate 0-18 nuclear factor of activated T cells 5 Homo sapiens 121-126 30567472-6 2019 When treated with ulipristal acetate, both patient leiomyoma tissue and leiomyoma cells grown in 3-dimensional cultures show a decrease in the expression of NFAT5 protein, solute transporters AKR1B1 and SLC5A3, and results in an associated decline in the expression of proteoglycans, versican, aggrecan, and brevican. ulipristal acetate 18-36 nuclear factor of activated T cells 5 Homo sapiens 157-162 30567472-6 2019 When treated with ulipristal acetate, both patient leiomyoma tissue and leiomyoma cells grown in 3-dimensional cultures show a decrease in the expression of NFAT5 protein, solute transporters AKR1B1 and SLC5A3, and results in an associated decline in the expression of proteoglycans, versican, aggrecan, and brevican. ulipristal acetate 18-36 aldo-keto reductase family 1 member B Homo sapiens 192-198 30567472-6 2019 When treated with ulipristal acetate, both patient leiomyoma tissue and leiomyoma cells grown in 3-dimensional cultures show a decrease in the expression of NFAT5 protein, solute transporters AKR1B1 and SLC5A3, and results in an associated decline in the expression of proteoglycans, versican, aggrecan, and brevican. ulipristal acetate 18-36 solute carrier family 5 member 3 Homo sapiens 203-209 30015921-8 2018 Expression of p21 and p27 was upregulated, while cyclin E and CDK2 were downregulated in UPA-treated primary-cultured leiomyoma cells. ulipristal acetate 89-92 H3 histone pseudogene 16 Homo sapiens 14-17 30015921-8 2018 Expression of p21 and p27 was upregulated, while cyclin E and CDK2 were downregulated in UPA-treated primary-cultured leiomyoma cells. ulipristal acetate 89-92 cyclin dependent kinase 2 Homo sapiens 62-66 30554215-1 2019 BACKGROUND/AIMS: Ulipristal acetate ([UPA], Esmya ) is an orally active selective progesterone-receptor modulator that has been approved as preoperative treatment for uterine myomas. ulipristal acetate 17-35 proline rich acidic protein 1 Homo sapiens 38-41 29525690-0 2018 Ulipristal acetate decreases transforming growth factor beta3 serum and tumor tissue concentrations in patients with uterine fibroids. ulipristal acetate 0-18 transforming growth factor beta 3 Homo sapiens 29-61 29227976-1 2018 OBJECTIVE: To investigate whether ulipristal acetate (UPA) treatment modifies the expression of progesterone receptor (PR), its nuclear cofactors steroid receptor coactivator-1 (SRC1) and nuclear corepressor-1 (NCoR1), prosurvival factor B-cell lymphoma 2 (Bcl-2), and Akt in uterine myomas. ulipristal acetate 34-52 BCL2 apoptosis regulator Homo sapiens 238-255 29227976-1 2018 OBJECTIVE: To investigate whether ulipristal acetate (UPA) treatment modifies the expression of progesterone receptor (PR), its nuclear cofactors steroid receptor coactivator-1 (SRC1) and nuclear corepressor-1 (NCoR1), prosurvival factor B-cell lymphoma 2 (Bcl-2), and Akt in uterine myomas. ulipristal acetate 34-52 BCL2 apoptosis regulator Homo sapiens 257-262 29227976-1 2018 OBJECTIVE: To investigate whether ulipristal acetate (UPA) treatment modifies the expression of progesterone receptor (PR), its nuclear cofactors steroid receptor coactivator-1 (SRC1) and nuclear corepressor-1 (NCoR1), prosurvival factor B-cell lymphoma 2 (Bcl-2), and Akt in uterine myomas. ulipristal acetate 34-52 nuclear receptor corepressor 1 Homo sapiens 211-216 29227976-1 2018 OBJECTIVE: To investigate whether ulipristal acetate (UPA) treatment modifies the expression of progesterone receptor (PR), its nuclear cofactors steroid receptor coactivator-1 (SRC1) and nuclear corepressor-1 (NCoR1), prosurvival factor B-cell lymphoma 2 (Bcl-2), and Akt in uterine myomas. ulipristal acetate 34-52 AKT serine/threonine kinase 1 Homo sapiens 269-272 27539216-1 2017 DESIGN: A 45-year-old woman with a symptomatic uterine myoma suffering from heavy menstrual bleeding, incontinence, and pain pressure received ulipristal acetate (UPA [Esmya; Gideon Richter, Budapest, Hungary]) for 6 months. ulipristal acetate 143-161 proline rich acidic protein 1 Homo sapiens 163-166 28403922-4 2017 Ulipristal acetate, a selective progesterone receptor modulator, exerts an antagonist effect on fibroid tissue, inducing apoptosis. ulipristal acetate 0-18 progesterone receptor Homo sapiens 32-53 30845294-1 2018 INTRODUCTION: Selective progesterone receptor modulators (SPRMs), such as Mifepristone, Asoprisnil, Ulipristal acetate (UPA) and Vilaprisan, were tested for their antiproliferative effects on uterine fibroids. ulipristal acetate 120-123 progesterone receptor Homo sapiens 24-45 28482329-5 2017 The specific spectrum of morphological changes due to ulipristal acetate, named progesterone receptor modulator associated endometrial changes (PAEC), occurs to be reversible after discontinuing ulipristal acetate. ulipristal acetate 54-72 progesterone receptor Homo sapiens 80-101 28482329-5 2017 The specific spectrum of morphological changes due to ulipristal acetate, named progesterone receptor modulator associated endometrial changes (PAEC), occurs to be reversible after discontinuing ulipristal acetate. ulipristal acetate 195-213 progesterone receptor Homo sapiens 80-101 24191519-5 2013 So far, ulipristal acetate has been approved for emergency contraception, mifepristone as a progesterone receptor antagonist because of the unique property of this compound for termination of pregnancy Recently the European Commission has authorized ulipristal acetate for the pre-operative treatment of uterine fibroids. ulipristal acetate 8-26 progesterone receptor Homo sapiens 92-113 27740868-0 2016 Safety of treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. ulipristal acetate 92-110 progesterone receptor Homo sapiens 59-80 27740868-5 2016 Expert opinion: Data from published reports of randomized controlled trials (RCTs) over 5 years have demonstrated that UPA does indeed induce endometrial changes (known as progesterone receptor modulator-associated endometrial changes), but they have been shown to be both benign and reversible. ulipristal acetate 119-122 progesterone receptor Homo sapiens 172-193 26990098-1 2016 BACKGROUND: The aim of this paper was to evaluate an Italian pharmacoeconomic profile of repeated-intermittent (from 4 to 10 cycles) use of ulipristal acetate 5 mg (UPA 5 mg) in comparison with the use of UPA 5 mg before surgery (2 cycles) for the management of symptomatic uterine fibroids. ulipristal acetate 140-158 proline rich acidic protein 1 Homo sapiens 165-168 26474308-0 2015 Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl2-L1 Expression. ulipristal acetate 0-18 progesterone receptor Homo sapiens 28-49 26474308-0 2015 Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl2-L1 Expression. ulipristal acetate 0-18 BCL2 like 1 Homo sapiens 107-114 25554579-1 2015 The three stereoisomers, 11alpha,17alpha-isomer I, 11alpha,17beta-isomer II and 11beta,17beta-isomer III are related substances of the selective progesterone receptor modulator Ulipristal acetate. ulipristal acetate 177-195 progesterone receptor Homo sapiens 145-166 27246982-9 2016 The PR inhibitor, ulipristal acetate (UPA), was able to reverse this aberrant progesterone-induced proliferation. ulipristal acetate 18-36 progesterone receptor Homo sapiens 4-6 26045548-1 2015 Ulipristal acetate (UPA) is a new selective progesterone receptor (PR) modulator used for emergency contraception. ulipristal acetate 0-18 progesterone receptor Homo sapiens 44-65 26045548-1 2015 Ulipristal acetate (UPA) is a new selective progesterone receptor (PR) modulator used for emergency contraception. ulipristal acetate 0-18 progesterone receptor Homo sapiens 67-69 25193534-0 2014 A randomized study on pharmacodynamic effects of vaginal rings delivering the progesterone receptor modulator ulipristal acetate: research for a novel estrogen-free, method of contraception. ulipristal acetate 110-128 progesterone receptor Homo sapiens 78-99 25204619-4 2014 Ulipristal acetate (UPA), a highly potent PR antagonist, has recently come onto the market and is much more selective for PR than the other oxo-steroid receptors (androgen, AR, glucocorticoid, GR, and mineralocorticoid, MR receptors) and, remarkably, it displays lower GR-inactivating potency than RU486. ulipristal acetate 0-18 progesterone receptor Homo sapiens 42-44 25204619-4 2014 Ulipristal acetate (UPA), a highly potent PR antagonist, has recently come onto the market and is much more selective for PR than the other oxo-steroid receptors (androgen, AR, glucocorticoid, GR, and mineralocorticoid, MR receptors) and, remarkably, it displays lower GR-inactivating potency than RU486. ulipristal acetate 0-18 progesterone receptor Homo sapiens 122-124 25001022-8 2014 Ulipristal acetate decreased INHBA, FST, ActRIIB, and Alk4 mRNA expressions in leiomyoma cultured cells. ulipristal acetate 0-18 inhibin subunit beta A Homo sapiens 29-34 25001022-8 2014 Ulipristal acetate decreased INHBA, FST, ActRIIB, and Alk4 mRNA expressions in leiomyoma cultured cells. ulipristal acetate 0-18 activin A receptor type 2B Homo sapiens 41-48 25001022-8 2014 Ulipristal acetate decreased INHBA, FST, ActRIIB, and Alk4 mRNA expressions in leiomyoma cultured cells. ulipristal acetate 0-18 activin A receptor type 1B Homo sapiens 54-58 23012316-1 2013 Ulipristal acetate (UPA), a progesterone receptor (PR) modulator, is used as an emergency contraceptive in women. ulipristal acetate 0-18 progesterone receptor Homo sapiens 28-49 23012316-1 2013 Ulipristal acetate (UPA), a progesterone receptor (PR) modulator, is used as an emergency contraceptive in women. ulipristal acetate 0-18 progesterone receptor Homo sapiens 51-53