PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11502733-9	2001	Treatment of the lung cells with 100 microM emodin or purpurin (1,2,4-trihydroxyanthraquinone) for 24 h produced greater induction of P450s 1A1 and 1B1 mRNA than did anthraflavic acid (2,6-dihydroxyanthraquinone) or anthraquinone.	Anthraquinones	80-93	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	134-151
12031447-2	2002	Recombinant HPPD from arabidopsis is sensitive to several classes of natural compounds including, in decreasing order of sensitivity, triketones, benzoquinones, naphthoquinones and anthraquinones.	Anthraquinones	181-195	4-hydroxyphenylpyruvate dioxygenase	Arabidopsis thaliana	12-16
9711216-0	1998	K1115 A, a new anthraquinone derivative that inhibits the binding of activator protein-1 (AP-1) to its recognition sites.	Anthraquinones	15-28	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-88
11697035-0	2001	Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH.	Anthraquinones	66-79	2,4-dienoyl-CoA reductase 1	Homo sapiens	137-142
11212108-2	2001	These anthraquinone-peptides showed DNA intercalative binding and inhibition of AP-1 protein binding to its DNA consensus sequence.	Anthraquinones	6-19	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-84
10850429-0	2000	Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam.	Anthraquinones	110-123	catenin (cadherin associated protein), beta 1	Mus musculus	0-12
10850429-3	2000	In this study, beta-catenin mutations were identified in all 19 anthraquinone-induced hepatoblastomas and all 8 oxazepam-induced hepatoblastomas examined.	Anthraquinones	64-77	catenin (cadherin associated protein), beta 1	Mus musculus	15-27
11138458-12	2000	CONCLUSIONS: The riboflavin-mediated photodegradation of ADR is an oxidative process resulting in the cleavage of the anthraquinone moiety.	Anthraquinones	118-131	aldo-keto reductase family 1 member B	Homo sapiens	57-60
10603942-6	1998	Exogenous effectors found to affect RyR function include ryanoids, toxins, xanthines, anthraquinones, phenol derivatives, adenosine and purinergic agonists and antagonists, NO donors, oxidizing reagents, dantrolene, local anesthetics, and polycationic reagents.	Anthraquinones	86-100	ryanodine receptor 1	Homo sapiens	36-39
9705221-4	1998	Transiently expressed human UGT1A8 shows glucuronidation activities with coumarins, anthraquinones, flavonoids, phenolic compounds, catechol estrogens, 17-hydroxyandrogens, primary amines such as the carcinogen 4-aminobiphenyl, and certain opioids.	Anthraquinones	84-98	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	28-34
9616184-7	1998	In addition to amines, expressed human UGT1A3 catalyzed the glucuronidation of opioids (e.g. morphine and buprenorphine), coumarins, flavonoids (e.g. naringenin and quercetin), anthraquinones, and small phenolic compounds (e.g. 4-nitrophenol).	Anthraquinones	177-191	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	39-45
10497143-7	1999	The catalytic activity of stably expressed UGT1A8 toward catechol estrogens, coumarins, flavonoids, anthraquinones, and phenolic compounds was much higher than that of UGT1A10.	Anthraquinones	100-114	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	43-49
10497143-7	1999	The catalytic activity of stably expressed UGT1A8 toward catechol estrogens, coumarins, flavonoids, anthraquinones, and phenolic compounds was much higher than that of UGT1A10.	Anthraquinones	100-114	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	168-175
9711216-0	1998	K1115 A, a new anthraquinone derivative that inhibits the binding of activator protein-1 (AP-1) to its recognition sites.	Anthraquinones	15-28	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	90-94
9488113-4	1998	The superoxide production observed during NADPH-cytochrome P450 reductase-dependent monoelectronic reduction of four xenobiotics, menadione, anthraquinone, nitrofurazone and diquat, was also investigated in these cultured cells at confluence.	Anthraquinones	141-154	cytochrome p450 oxidoreductase	Rattus norvegicus	42-73
11671566-5	1997	The tetrahydroanthraquinones 13a-c/14a-c are hydroxylated at C-4 to the phenolic anthraquinones 16a-c upon treatment with excess NMO.	Anthraquinones	14-28	complement C4A (Rodgers blood group)	Homo sapiens	61-64
9153311-2	1997	Conjugate 11, in which the TFO is linked via a hexamethylene bridge to the O-4 on the D ring of the anthraquinone moiety, affords the most stable triple helix, through intercalation of the planar chromophore between DNA bases and binding of both the TFO and the amino sugar to the major and the minor groove respectively.	Anthraquinones	100-113	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	75-78
8721305-5	1996	Furthermore, immobilised anthraquinone-dyes were able to discriminate between the mitochondrial and the cytoplasmic MDH isoenzymes, binding only to the former.	Anthraquinones	25-38	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	116-119
8990274-1	1997	L-Malate dehydrogenase (MDH) from Pseudomonas stutzeri was purified to homogeneity by a two-step procedure comprising anion-exchange chromatography and affinity chromatography on immobilized anthraquinone alpha-ketocarboxyl biomimetic dye.	Anthraquinones	191-204	malate dehydrogenase	Pseudomonas stutzeri	2-22
8980942-9	1996	This seems not to be related to chronic laxative use, since anthranoids cause a reduction in the levels of inhibitory neurotransmitters (VIP, somatostatin), but not of substance P, in the rat colon.	Anthraquinones	60-71	vasoactive intestinal peptide	Rattus norvegicus	137-140
8980942-9	1996	This seems not to be related to chronic laxative use, since anthranoids cause a reduction in the levels of inhibitory neurotransmitters (VIP, somatostatin), but not of substance P, in the rat colon.	Anthraquinones	60-71	somatostatin	Rattus norvegicus	142-154
8806713-7	1996	It was found that both rat and human UGT1.1 exhibited comparable substrate specificities and efficiencies (Vmax/Km) of glucuronide formation for anthraquinones, coumarins, estrogens, flavonoids, and phenolic compounds.	Anthraquinones	145-159	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
8663906-0	1996	The direct reduction of cytochrome c by some anthraquinone antitumor compounds.	Anthraquinones	45-58	cytochrome c, somatic	Homo sapiens	24-36
8663906-1	1996	The ability of various anthraquinone antitumor agents to undergo oxidative metabolism with concomitant cytochrome c reduction has been examined.	Anthraquinones	23-36	cytochrome c, somatic	Homo sapiens	103-115
7547985-1	1995	Damnacanthal, an anthraquinone isolated from a plant extract, was found to be a potent, selective inhibitor of p56lck tyrosine kinase activity.	Anthraquinones	17-30	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	111-117
8557582-0	1995	Protein tyrosine kinase and protein kinase C inhibition by fungal anthraquinones related to emodin.	Anthraquinones	66-80	EPH receptor A8	Homo sapiens	0-23
8849331-1	1995	The effect of the anthranoids, anthralin and hypericin, on epidermal growth factor receptor (EGF-R) activation and their degree of specificity was examined.	Anthraquinones	18-29	epidermal growth factor receptor	Homo sapiens	59-91
8849331-1	1995	The effect of the anthranoids, anthralin and hypericin, on epidermal growth factor receptor (EGF-R) activation and their degree of specificity was examined.	Anthraquinones	18-29	epidermal growth factor receptor	Homo sapiens	93-98
7532534-0	1995	Effects of long-term treatment with anthranoids and sodium picosulphate on the contents of vasoactive intestinal polypeptide, somatostatin and substance P in the rat colon.	Anthraquinones	36-47	vasoactive intestinal peptide	Rattus norvegicus	91-124
7532534-0	1995	Effects of long-term treatment with anthranoids and sodium picosulphate on the contents of vasoactive intestinal polypeptide, somatostatin and substance P in the rat colon.	Anthraquinones	36-47	somatostatin	Rattus norvegicus	126-138
7532534-10	1995	CONCLUSIONS: Chronic treatment with anthranoids in high doses, but not with sodium picosulphate, reduces VIP and somatostatin levels in the rat colon.	Anthraquinones	36-47	vasoactive intestinal peptide	Rattus norvegicus	105-108
7532534-10	1995	CONCLUSIONS: Chronic treatment with anthranoids in high doses, but not with sodium picosulphate, reduces VIP and somatostatin levels in the rat colon.	Anthraquinones	36-47	somatostatin	Rattus norvegicus	113-125
7872687-2	1994	The reduction of AQs performed by NADH-dehydrogenase, NADPH-cytochrome P-450 reductase, homogenates and microsomes of V79 cells, indicated that only the carboxy-containing drugs were fairly good superoxide anion stimulators.	Anthraquinones	17-20	NADPH--cytochrome P450 reductase	Cricetulus griseus	54-86
1311584-0	1992	NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals.	Anthraquinones	93-106	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	43-56
7698078-3	1994	UGT-HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT-HP4 was more accepting of nonplanar phenols, anthraquinones, flavones, alphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Anthraquinones	138-152	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-3
7698078-3	1994	UGT-HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT-HP4 was more accepting of nonplanar phenols, anthraquinones, flavones, alphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Anthraquinones	138-152	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	89-92
7698078-3	1994	UGT-HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT-HP4 was more accepting of nonplanar phenols, anthraquinones, flavones, alphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Anthraquinones	138-152	defensin alpha 4	Homo sapiens	93-96
7909572-5	1994	The classical MDR phenotype is caused by enhanced cellular drug efflux due to increased activity of a membrane-bound glycoprotein (P-glycoprotein) drug pump, that can pump out anthracyclines, anthracenediones, vinca alkaloids and epipodophyllotoxins, thereby actively lowering the intracellular drug concentrations to sublethal levels.	Anthraquinones	192-208	ATP binding cassette subfamily B member 1	Homo sapiens	131-145
8236271-3	1993	UGT HP1 exhibited a limited specificity for planar phenolic compounds, whereas UGT HP4 was more promiscuous in acceptance of non-planar phenols, anthraquinones, flavones, aliphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Anthraquinones	145-159	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-3
8236271-3	1993	UGT HP1 exhibited a limited specificity for planar phenolic compounds, whereas UGT HP4 was more promiscuous in acceptance of non-planar phenols, anthraquinones, flavones, aliphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Anthraquinones	145-159	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	79-82
8236271-3	1993	UGT HP1 exhibited a limited specificity for planar phenolic compounds, whereas UGT HP4 was more promiscuous in acceptance of non-planar phenols, anthraquinones, flavones, aliphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Anthraquinones	145-159	defensin alpha 4	Homo sapiens	83-86
1280117-1	1992	Dynemicin A, which is a hybrid antitumor antibiotic containing anthraquinone and enediyne cores, abstracts the C-1" hydrogen of DNA deoxyribose and then the damaged DNA leads to strand breaks with the formation of 5"- and 3"-phosphate termini.	Anthraquinones	63-76	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	111-114
1466788-0	1992	Inhibition of myosin light chain kinase, cAMP-dependent protein kinase, protein kinase C and of plant Ca(2+)-dependent protein kinase by anthraquinones.	Anthraquinones	137-151	calcium-dependent protein kinase 19	Triticum aestivum	102-133
1466788-3	1992	Wheat germ Ca(2+)-dependent protein kinase (CDPK) assayed with a myosin light chain-based peptide substrate is much less sensitive to inhibition by anthraquinones, the most effective anthraquinone inhibitors being the 1,2,4-trihydroxy (IC50 14 microM), 1,8-dihydroxy-3-methyl (IC50 56 microM) and 1,2,5,8-tetrahydroxy (IC50 65 microM) derivatives.	Anthraquinones	148-162	calcium-dependent protein kinase 19	Triticum aestivum	11-42
1466788-3	1992	Wheat germ Ca(2+)-dependent protein kinase (CDPK) assayed with a myosin light chain-based peptide substrate is much less sensitive to inhibition by anthraquinones, the most effective anthraquinone inhibitors being the 1,2,4-trihydroxy (IC50 14 microM), 1,8-dihydroxy-3-methyl (IC50 56 microM) and 1,2,5,8-tetrahydroxy (IC50 65 microM) derivatives.	Anthraquinones	148-162	calcium-dependent protein kinase 19	Triticum aestivum	44-48
1466788-3	1992	Wheat germ Ca(2+)-dependent protein kinase (CDPK) assayed with a myosin light chain-based peptide substrate is much less sensitive to inhibition by anthraquinones, the most effective anthraquinone inhibitors being the 1,2,4-trihydroxy (IC50 14 microM), 1,8-dihydroxy-3-methyl (IC50 56 microM) and 1,2,5,8-tetrahydroxy (IC50 65 microM) derivatives.	Anthraquinones	148-161	calcium-dependent protein kinase 19	Triticum aestivum	11-42
1466788-3	1992	Wheat germ Ca(2+)-dependent protein kinase (CDPK) assayed with a myosin light chain-based peptide substrate is much less sensitive to inhibition by anthraquinones, the most effective anthraquinone inhibitors being the 1,2,4-trihydroxy (IC50 14 microM), 1,8-dihydroxy-3-methyl (IC50 56 microM) and 1,2,5,8-tetrahydroxy (IC50 65 microM) derivatives.	Anthraquinones	148-161	calcium-dependent protein kinase 19	Triticum aestivum	44-48
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Anthraquinones	120-134	calmodulin 1	Rattus norvegicus	7-17
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Anthraquinones	120-134	myosin light chain kinase	Rattus norvegicus	28-53
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Anthraquinones	120-134	myosin light chain kinase	Rattus norvegicus	55-59
1466788-6	1992	A range of anthraquinone derivatives inhibits the catalytic subunit of cAMP-dependent protein kinase (cAK).	Anthraquinones	11-24	cyclin-dependent kinase 7	Rattus norvegicus	71-100
1466788-6	1992	A range of anthraquinone derivatives inhibits the catalytic subunit of cAMP-dependent protein kinase (cAK).	Anthraquinones	11-24	cyclin-dependent kinase 7	Rattus norvegicus	102-105
1324690-3	1992	This method is based on the ability of anthraquinones to decrease the amount of enzymatic cytochrome c reduction at low concentrations of NADH.	Anthraquinones	39-53	cytochrome c, somatic	Homo sapiens	90-102
1324690-6	1992	On the other hand, the extent of the diminution of cytochrome c reduction by anthraquinones depended strongly on the structure of the compounds examined.	Anthraquinones	77-91	cytochrome c, somatic	Homo sapiens	51-63
1578486-0	1992	Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.	Anthraquinones	6-19	elastase, neutrophil expressed	Homo sapiens	34-58
1578486-0	1992	Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.	Anthraquinones	6-19	cathepsin G	Homo sapiens	63-74
1578486-1	1992	A large series of variously substituted anthraquinones has been synthesized and assayed for inhibitory capacity against human leukocyte elastase (HLE) and cathepsin G (CatG), two serine proteinases implicated in diseases characterized by the abnormal degradation of connective tissue, such as pulmonary emphysema and rheumatoid arthritis.	Anthraquinones	40-54	elastase, neutrophil expressed	Homo sapiens	120-144
1578486-1	1992	A large series of variously substituted anthraquinones has been synthesized and assayed for inhibitory capacity against human leukocyte elastase (HLE) and cathepsin G (CatG), two serine proteinases implicated in diseases characterized by the abnormal degradation of connective tissue, such as pulmonary emphysema and rheumatoid arthritis.	Anthraquinones	40-54	elastase, neutrophil expressed	Homo sapiens	146-149
1578486-1	1992	A large series of variously substituted anthraquinones has been synthesized and assayed for inhibitory capacity against human leukocyte elastase (HLE) and cathepsin G (CatG), two serine proteinases implicated in diseases characterized by the abnormal degradation of connective tissue, such as pulmonary emphysema and rheumatoid arthritis.	Anthraquinones	40-54	cathepsin G	Homo sapiens	155-166
1578486-1	1992	A large series of variously substituted anthraquinones has been synthesized and assayed for inhibitory capacity against human leukocyte elastase (HLE) and cathepsin G (CatG), two serine proteinases implicated in diseases characterized by the abnormal degradation of connective tissue, such as pulmonary emphysema and rheumatoid arthritis.	Anthraquinones	40-54	cathepsin G	Homo sapiens	168-172
1731940-0	1992	Inhibition of NAD(P)H:(quinone-acceptor) oxidoreductase by cibacron blue and related anthraquinone dyes: a structure-activity study.	Anthraquinones	85-98	thioredoxin reductase 1	Homo sapiens	41-55
8095226-3	1993	UGT HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT HP4 was more promiscuous in acceptance of non-planar phenols, anthraquinones, flavones, aliphatic alcohols, aromatic carboxylic acids, steroids, and many drugs of varied structure.	Anthraquinones	155-169	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-3
8095226-3	1993	UGT HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT HP4 was more promiscuous in acceptance of non-planar phenols, anthraquinones, flavones, aliphatic alcohols, aromatic carboxylic acids, steroids, and many drugs of varied structure.	Anthraquinones	155-169	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	89-92
8095226-3	1993	UGT HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT HP4 was more promiscuous in acceptance of non-planar phenols, anthraquinones, flavones, aliphatic alcohols, aromatic carboxylic acids, steroids, and many drugs of varied structure.	Anthraquinones	155-169	defensin alpha 4	Homo sapiens	93-96
8378189-8	1993	These results and other findings indicate that LH-RH analogs containing cytotoxic radicals anthraquinone or methotrexate retain their hormonal activity after administration in vivo, and can effectively inhibit tumor growth.	Anthraquinones	91-104	gonadotropin releasing hormone 1	Rattus norvegicus	47-52
1466788-0	1992	Inhibition of myosin light chain kinase, cAMP-dependent protein kinase, protein kinase C and of plant Ca(2+)-dependent protein kinase by anthraquinones.	Anthraquinones	137-151	myosin light chain kinase	Rattus norvegicus	14-39
1311584-1	1992	The anthraquinone-based antitumour agents mitoxantrone, daunorubicin and ametantrone were found to be substrates for NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase) [QAO] isolated from rat liver.	Anthraquinones	4-17	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	160-173
7835232-6	1994	UGT2B15 stably expressed in HK293 cells displayed glucuronidation activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites.	Anthraquinones	199-213	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	0-7
2380311-5	1990	Reactive Blue 2 analogues were bonded onto an agarose support matrix by a novel method which entailed immobilisation by the anthraquinone ring 1-amino group as opposed to the usual triazine ring coupling methods.	Anthraquinones	124-137	ring finger protein 1	Equus caballus	138-144
2380311-6	1990	Dyes with spacer arms attached to the anthraquinone ring 1-amino group were synthesised by reacting methoxytriazine analogues of C.I.	Anthraquinones	38-51	ring finger protein 1	Equus caballus	52-58
2380311-9	1990	Reactive Blue 2 analogues with derivatised anthraquinone ring 1-amino groups were of a characteristic red colour.	Anthraquinones	43-56	ring finger protein 1	Equus caballus	57-63
2380311-10	1990	This change of chromaticity was entirely expected since the anthraquinone ring 1-amino group is an important component of the C.I.	Anthraquinones	60-73	ring finger protein 1	Equus caballus	74-80
2155616-0	1990	Inhibition by new anthraquinone compounds, K-259-2 and KS-619-1, of calmodulin-dependent cyclic nucleotide phosphodiesterase.	Anthraquinones	18-31	calmodulin	Bos taurus	68-78
2155616-1	1990	K-259-2 and KS-619-1, novel anionic anthraquinone metabolites isolated from culture broth of microorganisms, inhibited activation of bovine brain phosphodiesterase induced by calmodulin (CaM), sodium oleate, or limited proteolysis with almost equal potency.	Anthraquinones	36-49	calmodulin	Bos taurus	175-185
2210426-3	1990	MACs for anthraquinones, alpha-aminoanthraquinones and K-type dispersal dye-stuff were established at 5 mg/m3.	Anthraquinones	9-23	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-4
2210426-6	1990	The group MACs for the pigment and NF disperser containing dispersal anthraquinone dye-stuffs at 5 mg/m3 was established and subsequently formally adopted.	Anthraquinones	69-82	myristoylated alanine rich protein kinase C substrate	Homo sapiens	10-14
34899321-0	2021	3D-QSAR, Molecular Docking, and MD Simulations of Anthraquinone Derivatives as PGAM1 Inhibitors.	Anthraquinones	50-63	phosphoglycerate mutase 1	Homo sapiens	79-84
34894599-0	2022	Electrografted anthraquinone to monitor pH at the biofilm-anode interface in a wastewater microbial fuel cell.	Anthraquinones	15-28	phenylalanine hydroxylase	Homo sapiens	40-42
34894599-1	2022	Electrografted anthraquinone on graphite was used as a probe to monitor the pH change at the biofilm-electrode interface at the anode of a microbial fuel cell inoculated with wastewater.	Anthraquinones	15-28	phenylalanine hydroxylase	Homo sapiens	76-78
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Anthraquinones	105-119	NFE2 like bZIP transcription factor 2	Homo sapiens	279-283
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Anthraquinones	105-119	AKT serine/threonine kinase 1	Homo sapiens	292-295
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Anthraquinones	105-119	NLR family pyrin domain containing 3	Homo sapiens	319-324
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Anthraquinones	105-119	tumor necrosis factor	Homo sapiens	326-335
34899321-2	2021	Recently, a series of inhibitors with various structures targeting PGAM1 have been reported, particularly anthraquinone derivatives.	Anthraquinones	106-119	phosphoglycerate mutase 1	Homo sapiens	67-72
34899321-9	2021	The study explored the structure-activity relationships of anthraquinone compounds through 3D-QSAR and molecular dynamics simulations and provided theoretical guidance for the rational design of new anthraquinone derivatives as PGAM1 inhibitors.	Anthraquinones	59-72	phosphoglycerate mutase 1	Homo sapiens	228-233
34899321-9	2021	The study explored the structure-activity relationships of anthraquinone compounds through 3D-QSAR and molecular dynamics simulations and provided theoretical guidance for the rational design of new anthraquinone derivatives as PGAM1 inhibitors.	Anthraquinones	199-212	phosphoglycerate mutase 1	Homo sapiens	228-233
34746186-14	2021	From the overall analyses, we can conclude that Dihydroaltersolanol C, Anthraquinone, Nigbeauvin A, and Catechin are classified as promising candidates for PLpro, thus potentially useful in developing a medicine for COVID-19.	Anthraquinones	71-84	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	156-161
34509444-0	2021	Simultaneous determination of flavonoids and anthraquinones in honey by using SPE-CE-LIF.	Anthraquinones	45-59	LIF interleukin 6 family cytokine	Homo sapiens	85-88
35290845-3	2022	Modeling and structural biology guided the optimization of a PKL-specific anthraquinone-based compound.	Anthraquinones	74-87	pyruvate kinase L/R	Homo sapiens	61-64
34065710-5	2021	As a result, anthraquinone (AQ) and rutin were discovered to be new OR6M1 ligands.	Anthraquinones	13-26	olfactory receptor family 6 subfamily M member 1	Homo sapiens	68-73
34065710-5	2021	As a result, anthraquinone (AQ) and rutin were discovered to be new OR6M1 ligands.	Anthraquinones	28-30	olfactory receptor family 6 subfamily M member 1	Homo sapiens	68-73
34065710-6	2021	Based on calcium imaging in OR6M1-expressing Hana3A cells, AQ and rutin were classified as an OR6M1 agonist and antagonist, respectively.	Anthraquinones	59-61	olfactory receptor family 6 subfamily M member 1	Homo sapiens	28-33
34065710-6	2021	Based on calcium imaging in OR6M1-expressing Hana3A cells, AQ and rutin were classified as an OR6M1 agonist and antagonist, respectively.	Anthraquinones	59-61	olfactory receptor family 6 subfamily M member 1	Homo sapiens	94-99
34296720-4	2021	Moreover, a Ru(iii) centre and an anthraquinone anion centre may be generated upon irradiation, which can further oxidize NADH/NADPH and generate O2 -, successfully eliciting photoredox catalysis and photodynamic therapy (PDT).	Anthraquinones	34-47	2,4-dienoyl-CoA reductase 1	Homo sapiens	127-132
34225167-0	2021	Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.	Anthraquinones	25-38	transthyretin	Homo sapiens	72-85
34225167-4	2021	Here, we investigated the inhibitory activities of anthraquinone and xanthone derivatives against amyloid aggregation, and found that xanthone-2-carboxylic acid with one chlorine or methyl group has strong inhibitory activity comparable with that of diflunisal, which is one of the best known stabilizers of transthyretin.	Anthraquinones	51-64	transthyretin	Homo sapiens	308-321
34075985-3	2021	In this work, we report the design and synthesis of anthraquinone-based metal-organic cages (MOCs) for the (2 + 2) photocycloaddition of chalcones to generate syn-HH cyclobutanes.	Anthraquinones	52-65	synemin	Homo sapiens	159-162
34201046-12	2021	A significant increase in anthraquinone dye staining was observed with the addition of NELL-1, and the highest value was noted at 10 ng/mL (p < 0.05).	Anthraquinones	26-39	neural EGFL like 1	Homo sapiens	87-93
35034970-6	2022	Blind molecular docking studies of 13 anthraquinones and one control drug (Boceprevir) with SARS-CoV-2 Mpro were carried out using the SwissDOCK server, and alterporriol-Q that showed the highest binding affinity towards Mpro were subjected to molecular dynamics simulation studies.	Anthraquinones	38-52	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	103-107
35197857-3	2022	We hypothesized that natural anthraquinone derivative emodin can protect against neurotoxicity induced by pathological concentrations of zinc via the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and alleviate oxidative stress and mitochondrial dysfunction.	Anthraquinones	29-42	mitogen-activated protein kinase 3	Homo sapiens	193-199
35034970-7	2022	This study indicated that several antiviral anthraquinones could prove to be effective inhibitors for SARS-CoV-2 Mpro of COVID-19 as they bind near the active site having the catalytic dyad, HIS41 and CYS145 through non-covalent forces.	Anthraquinones	44-58	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	113-117
35034970-9	2022	Among the anthraquinones studied, alterporriol-Q was found to be the most potent inhibitor of SARS-CoV-2 Mpro.	Anthraquinones	10-24	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	105-109
35034970-6	2022	Blind molecular docking studies of 13 anthraquinones and one control drug (Boceprevir) with SARS-CoV-2 Mpro were carried out using the SwissDOCK server, and alterporriol-Q that showed the highest binding affinity towards Mpro were subjected to molecular dynamics simulation studies.	Anthraquinones	38-52	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	221-225
3114031-1	1987	Two anthracenedione antineoplastic agents, mitoxantrone and the nonhydroxylated analog, ametantrone, were found to inhibit hepatic microsomal cytochrome P-450-dependent drug metabolism in vitro and in vivo.	Anthraquinones	4-19	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	142-158
3126372-1	1988	Doxorubicin (DOX) and Mitomycin-C (MMC) are two anthraquinones which, when administered to rats, result in a decrease in the content of hepatic cytochrome P-450 and mixed function oxidase activities.	Anthraquinones	48-62	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	144-160
3114031-7	1987	The anthracenediones also inhibited hepatic cytochrome P-450-dependent monooxygenase activity in vivo, as evidenced by altered hexobarbital sleep times of mice.	Anthraquinones	4-20	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	44-60
6366529-2	1984	Upon incubating emodin with the hepatic S9 derived from PCB-pretreated rats, this anthraquinone exhibited mutagenicity in the presence of NADPH or NADH, and this enzymatic activation, maximal at pH 7.0 and occurring in the microsomes, was induced by the pretreatment of rats with PCB, 3-methyl-cholanthrene or phenobarbital and was inhibited by alpha-naphthoflavone, SKF 525A and carbon monoxide.	Anthraquinones	82-95	pyruvate carboxylase	Rattus norvegicus	56-59
2993283-6	1985	Mitoxantrone and ametantrone inhibited NADPH-cytochrome P-450 reductase- and xanthine oxidase-catalyzed conjugated diene formation from linoleic acid in a concentration-dependent manner with half-maximal inhibition achieved at approximately 0.5 microM anthracenedione.	Anthraquinones	252-267	cytochrome p450 oxidoreductase	Homo sapiens	39-72
6366529-2	1984	Upon incubating emodin with the hepatic S9 derived from PCB-pretreated rats, this anthraquinone exhibited mutagenicity in the presence of NADPH or NADH, and this enzymatic activation, maximal at pH 7.0 and occurring in the microsomes, was induced by the pretreatment of rats with PCB, 3-methyl-cholanthrene or phenobarbital and was inhibited by alpha-naphthoflavone, SKF 525A and carbon monoxide.	Anthraquinones	82-95	pyruvate carboxylase	Rattus norvegicus	280-283
33877317-0	2021	Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation.	Anthraquinones	12-25	AKT serine/threonine kinase 1	Homo sapiens	102-105
6408991-1	1983	Stimulation of the rates of NAD(P)H oxidation, superoxide generation, and hydrogen peroxide formation by three anthracenedione antineoplastic agents in the presence of NADPH-cytochrome P-450 reductase, NADH dehydrogenase, or rabbit hepatic microsomes was studied and the results compared with those obtained for the anthracyclines Adriamycin and daunorubicin.	Anthraquinones	111-126	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	168-200
6251919-1	1980	It has been shown that during fast (&lt; 1 ms) photosensitized by anthraquinone or benzophenone reduction of cytochrome c in 0.15 N NaOH water-glycerol solutions ferrocytochrome c in a nonequilibrium state with increased reactivity was formed.	Anthraquinones	66-79	cytochrome c, somatic	Homo sapiens	109-121
33722666-0	2021	Anthraquinone derivative C10 inhibits proliferation and cell cycle progression in colon cancer cells via the Jak2/Stat3 signaling pathway.	Anthraquinones	0-13	homeobox C10	Homo sapiens	25-28
33722666-0	2021	Anthraquinone derivative C10 inhibits proliferation and cell cycle progression in colon cancer cells via the Jak2/Stat3 signaling pathway.	Anthraquinones	0-13	Janus kinase 2	Homo sapiens	109-113
33722666-0	2021	Anthraquinone derivative C10 inhibits proliferation and cell cycle progression in colon cancer cells via the Jak2/Stat3 signaling pathway.	Anthraquinones	0-13	signal transducer and activator of transcription 3	Homo sapiens	114-119
33924269-2	2021	In the present study, the interaction of anthraquinone and diazo dichlorotriazine dyes (DCTD) with hGSTA1-1 was investigated.	Anthraquinones	41-54	glutathione S-transferase alpha 1	Homo sapiens	99-107
6274352-0	1981	Anthracenedione activation by NADPH-cytochrome P-450 reductase; comparison with anthracyclines.	Anthraquinones	0-15	cytochrome p450 oxidoreductase	Homo sapiens	30-62
34013303-2	2021	Redox species (anthraquinone (AQ), methylene blue (MB), and polydopamine (PDA)) are used as redox indicators for anchoring capture miRNA probes, which hybridize with the complementary targets, miRNA-21, miRNA-155, and miRNA-210, respectively.	Anthraquinones	15-28	microRNA 21	Homo sapiens	193-201
34013303-2	2021	Redox species (anthraquinone (AQ), methylene blue (MB), and polydopamine (PDA)) are used as redox indicators for anchoring capture miRNA probes, which hybridize with the complementary targets, miRNA-21, miRNA-155, and miRNA-210, respectively.	Anthraquinones	30-32	microRNA 155	Homo sapiens	203-212
33760108-0	2021	A novel anthraquinone-quinazoline hybrid 7B blocks breast cancer metastasis and EMT via targeting EGFR and Rac1.	Anthraquinones	8-21	epidermal growth factor receptor	Homo sapiens	98-102
33760108-0	2021	A novel anthraquinone-quinazoline hybrid 7B blocks breast cancer metastasis and EMT via targeting EGFR and Rac1.	Anthraquinones	8-21	Rac family small GTPase 1	Homo sapiens	107-111
33760108-3	2021	Based on the high expression of EGFR and Rac1 in TNBC and inspired by a novel antitumor strategy termed combi-targeting, novel anthraquinone-quinazoline hybrid 7B was synthesized to simultaneously target EGFR and Rac1.	Anthraquinones	127-140	epidermal growth factor receptor	Homo sapiens	32-36
33760108-3	2021	Based on the high expression of EGFR and Rac1 in TNBC and inspired by a novel antitumor strategy termed combi-targeting, novel anthraquinone-quinazoline hybrid 7B was synthesized to simultaneously target EGFR and Rac1.	Anthraquinones	127-140	Rac family small GTPase 1	Homo sapiens	41-45
33760108-3	2021	Based on the high expression of EGFR and Rac1 in TNBC and inspired by a novel antitumor strategy termed combi-targeting, novel anthraquinone-quinazoline hybrid 7B was synthesized to simultaneously target EGFR and Rac1.	Anthraquinones	127-140	epidermal growth factor receptor	Homo sapiens	204-208
33760108-3	2021	Based on the high expression of EGFR and Rac1 in TNBC and inspired by a novel antitumor strategy termed combi-targeting, novel anthraquinone-quinazoline hybrid 7B was synthesized to simultaneously target EGFR and Rac1.	Anthraquinones	127-140	Rac family small GTPase 1	Homo sapiens	213-217
33137430-4	2021	In our previous study, we found that anthraquinones derived from the herbal medicine Rheum palmatum L. (RP) inhibited both OAT1 and OAT3, with rhein exhibiting the greatest potency among the components.	Anthraquinones	37-51	solute carrier family 22 member 6	Rattus norvegicus	123-127
33368780-5	2021	In this existing approach, which highlights the binding efficacy of our anthraquinone compound, purpurin against phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) protein restrains the CRC cell growth by inhibiting phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), cell proliferation, and inducing apoptosis signaling.	Anthraquinones	72-85	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Homo sapiens	181-185
33368780-5	2021	In this existing approach, which highlights the binding efficacy of our anthraquinone compound, purpurin against phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) protein restrains the CRC cell growth by inhibiting phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), cell proliferation, and inducing apoptosis signaling.	Anthraquinones	72-85	protein tyrosine kinase 2 beta	Homo sapiens	269-285
33368780-5	2021	In this existing approach, which highlights the binding efficacy of our anthraquinone compound, purpurin against phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) protein restrains the CRC cell growth by inhibiting phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), cell proliferation, and inducing apoptosis signaling.	Anthraquinones	72-85	AKT serine/threonine kinase 1	Homo sapiens	292-295
33607072-0	2021	Aloe-emodin, a naturally occurring anthraquinone, is a highly potent mast cell stabilizer through activating mitochondrial calcium uniporter.	Anthraquinones	35-48	mitochondrial calcium uniporter	Homo sapiens	109-140
33417980-0	2021	Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B.	Anthraquinones	18-31	aurora kinase B	Homo sapiens	78-93
33137430-4	2021	In our previous study, we found that anthraquinones derived from the herbal medicine Rheum palmatum L. (RP) inhibited both OAT1 and OAT3, with rhein exhibiting the greatest potency among the components.	Anthraquinones	37-51	solute carrier family 22 member 8	Rattus norvegicus	132-136
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Anthraquinones	90-103	interleukin 1 beta	Homo sapiens	131-148
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Anthraquinones	90-103	interleukin 1 alpha	Homo sapiens	150-158
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Anthraquinones	90-103	tumor necrosis factor	Homo sapiens	164-191
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Anthraquinones	90-103	tumor necrosis factor	Homo sapiens	193-202
32973513-0	2020	Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3.	Anthraquinones	15-28	ectonucleoside triphosphate diphosphohydrolase 2	Homo sapiens	133-141
33438235-5	2021	Here, in silico (quantitative structure-activity relationship modeling) and in vitro (human recombinant enzymes and liver microsomes) methods were used to identify inhibitors of five major CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) among 22 anthraquinones.	Anthraquinones	257-271	peptidylprolyl isomerase G	Homo sapiens	189-192
33438235-5	2021	Here, in silico (quantitative structure-activity relationship modeling) and in vitro (human recombinant enzymes and liver microsomes) methods were used to identify inhibitors of five major CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) among 22 anthraquinones.	Anthraquinones	257-271	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	203-209
33438235-6	2021	First, in silico prediction and in vitro human recombinant enzyme assays were conducted for all compounds, and results showed that most of the anthraquinones were potent CYP1A2 inhibitors.	Anthraquinones	143-157	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	170-176
33438235-8	2021	Finally, plasma concentrations of the five anthraquinones in animal and humans were identified in the literature and compared to their in vitro inhibition potency (IC50 values) towards CYP activities.	Anthraquinones	43-57	peptidylprolyl isomerase G	Homo sapiens	185-188
33202286-0	2021	Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway.	Anthraquinones	17-30	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	89-93
33202286-0	2021	Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway.	Anthraquinones	17-30	sterol regulatory element binding transcription factor 2	Homo sapiens	94-101
33202286-0	2021	Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway.	Anthraquinones	17-30	proprotein convertase subtilisin/kexin type 9	Homo sapiens	102-107
33202286-0	2021	Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway.	Anthraquinones	17-30	low density lipoprotein receptor	Homo sapiens	108-112
33246826-1	2021	Physcion 8-O-beta-glucopyranoside (PSG), an anthraquinone extracted from Rumex japonicus Houtt, has various pharmacological effects, however, the effect of PSG on liver fibrosis and its related mechanism remain to be determined.	Anthraquinones	44-57	pregnancy-specific beta 1-glycoprotein	Rattus norvegicus	35-38
33321412-7	2021	In a CYP inhibition assay, the methanolic extract as well as the anthraquinones strongly inhibited the catalytic activity of CYP2C9 while, inhibition of CYP3A4 was weak.	Anthraquinones	65-79	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	125-131
33321412-7	2021	In a CYP inhibition assay, the methanolic extract as well as the anthraquinones strongly inhibited the catalytic activity of CYP2C9 while, inhibition of CYP3A4 was weak.	Anthraquinones	65-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	153-159
32667050-9	2020	Docking results showed that the combination of anthraquinones and NLRP3 were the best, and the top two chemical compounds were Purpurin and Rhein, which are the most promising NLRP3 inhibitors.	Anthraquinones	47-61	NLR family pyrin domain containing 3	Homo sapiens	176-181
32772313-2	2020	Hence, the present study aimed to investigate the reported anthraquinone derivatives as immune booster molecules in COVID-19 infection and evaluate their binding affinity with three reported targets of novel coronavirus i.e. 3C-like protease, papain-like protease, and spike protein.	Anthraquinones	59-72	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	269-274
32772313-6	2020	Finally, the docking was performed using autodock4 to identify the binding efficacy of anthraquinone derivatives with 3C-like protease, papain-like protease, and spike protein.	Anthraquinones	87-100	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	162-167
33466332-4	2021	In particular, cholinesterases (ChEs), beta-amyloid (Abeta) and tau proteins have been identified as key targets of these classes of compounds, where the NQ or AQ scaffold may contribute to the biological effect against AD as main unit or significant substructure.	Anthraquinones	160-162	amyloid beta precursor protein	Homo sapiens	39-59
33466332-4	2021	In particular, cholinesterases (ChEs), beta-amyloid (Abeta) and tau proteins have been identified as key targets of these classes of compounds, where the NQ or AQ scaffold may contribute to the biological effect against AD as main unit or significant substructure.	Anthraquinones	160-162	microtubule associated protein tau	Homo sapiens	64-67
33113663-7	2020	The excellent electrochemical activity demonstrates that the Ti/SnO2-RuO2 electrode presents a favorable application prospect in the electrochemical treatment of anthraquinone dye wastewater.	Anthraquinones	162-175	strawberry notch homolog 1	Homo sapiens	64-67
33077836-5	2020	In this paper five phytochemicals, which belong to flavonoid and anthraquinone subclass, have been selected as small molecules in molecular docking study of spike protein of SARS-CoV2 with its human receptor ACE2 molecule.	Anthraquinones	65-78	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	157-162
33077836-5	2020	In this paper five phytochemicals, which belong to flavonoid and anthraquinone subclass, have been selected as small molecules in molecular docking study of spike protein of SARS-CoV2 with its human receptor ACE2 molecule.	Anthraquinones	65-78	angiotensin converting enzyme 2	Homo sapiens	208-212
32464200-0	2020	Inhibitory effects of four anthraquinones on tyrosinase activity: Insight from spectroscopic analysis and molecular docking.	Anthraquinones	27-41	tyrosinase	Homo sapiens	45-55
32464200-1	2020	In this study, the inhibitory effects of four anthraquinones including chrysophanol, emodin, physcione and rhein on tyrosinase were investigated by enzyme inhibition assay.	Anthraquinones	46-60	tyrosinase	Homo sapiens	116-126
32464200-2	2020	The results indicated that all of anthraquinones could significantly inhibit the activity of tyrosinase in a competitive manner.	Anthraquinones	34-48	tyrosinase	Homo sapiens	93-103
32464200-3	2020	To gain insight into the inhibitory mechanism of anthraquinones on tyrosinase, spectroscopic analysis combined with molecular docking studies were performed.	Anthraquinones	49-63	tyrosinase	Homo sapiens	67-77
32464200-4	2020	Fluorescence results showed that anthraquinones interacted with tyrosinase by static quenching in a molecular ratio of 1:1.	Anthraquinones	33-47	tyrosinase	Homo sapiens	64-74
32464200-5	2020	Circular dichroism and molecular docking suggested that anthraquinones could not chelate directly the copper ions but they could bind to amino acid residues in the active site of tyrosinase via electrostatic forces and hydrophobic interactions, as well as hydrogen bonds, and the binding processes resulted in the conformational changes of tyrosinase and prevented the substrate (L-DOPA) from entering the active site, which led to the decrease of tyrosinase activity.	Anthraquinones	56-70	tyrosinase	Homo sapiens	179-189
32464200-5	2020	Circular dichroism and molecular docking suggested that anthraquinones could not chelate directly the copper ions but they could bind to amino acid residues in the active site of tyrosinase via electrostatic forces and hydrophobic interactions, as well as hydrogen bonds, and the binding processes resulted in the conformational changes of tyrosinase and prevented the substrate (L-DOPA) from entering the active site, which led to the decrease of tyrosinase activity.	Anthraquinones	56-70	tyrosinase	Homo sapiens	340-350
32464200-5	2020	Circular dichroism and molecular docking suggested that anthraquinones could not chelate directly the copper ions but they could bind to amino acid residues in the active site of tyrosinase via electrostatic forces and hydrophobic interactions, as well as hydrogen bonds, and the binding processes resulted in the conformational changes of tyrosinase and prevented the substrate (L-DOPA) from entering the active site, which led to the decrease of tyrosinase activity.	Anthraquinones	56-70	tyrosinase	Homo sapiens	340-350
32464200-6	2020	Our study in this paper provides a scientific basis for revealing the inhibition of tyrosinase activity by anthraquinone compounds.	Anthraquinones	107-120	tyrosinase	Homo sapiens	84-94
32464200-7	2020	As a natural inhibitor of tyrosinase, anthraquinones can be used as a potential agent to reduce enzymatic browning reactions, such as food browning and melanization of skin.	Anthraquinones	38-52	tyrosinase	Homo sapiens	26-36
32973513-0	2020	Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3.	Anthraquinones	15-28	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	146-154
32714771-2	2020	Herein, a supramolecular polymer is constructed through the host-guest interaction of anthraquinone-modified beta-cyclodextrin (AQ-beta-CD) in aqueous solution.	Anthraquinones	86-99	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	131-138
32784977-8	2020	Furthermore, the anthraquinone-rich dichloromethane fraction displayed the highest anticancer activity when evaluated in a human hepatoma cancer cell line (HepG2), in which it induced increased apoptosis mediated by p53 and caspase activation.	Anthraquinones	17-30	tumor protein p53	Homo sapiens	216-219
32573248-1	2020	Mechanically interlocking redox-active anthraquinone (AQ) like a rotaxane onto single-walled carbon nanotubes (AQ-MINT) gives a new and advanced example of a non-covalent architecture for an electrochemical platform.	Anthraquinones	39-52	spen family transcriptional repressor	Homo sapiens	114-118
32573248-1	2020	Mechanically interlocking redox-active anthraquinone (AQ) like a rotaxane onto single-walled carbon nanotubes (AQ-MINT) gives a new and advanced example of a non-covalent architecture for an electrochemical platform.	Anthraquinones	54-56	spen family transcriptional repressor	Homo sapiens	114-118
32573248-2	2020	Electrochemical studies of AQ-MINT as an electrode reveal enhanced electrochemical stability in both aqueous and organic solvents compared to physisorbed AQ-based electrodes.	Anthraquinones	27-29	spen family transcriptional repressor	Homo sapiens	30-34
32573248-4	2020	Using such AQ-MINT electrodes, 7 and 2micromol H2O2 were produced over 8h under basic and neutral conditions, while the control system of SWCNT showed 2.2 and 0.5micromol respectively.	Anthraquinones	11-13	spen family transcriptional repressor	Homo sapiens	14-18
31562564-5	2020	This molecule, an anthraquinone derivative named Purpurin, inhibited ~ 50% of PHF6 fibrillization in vitro at equimolar concentration and disassembled pre-formed PHF6 fibrils.	Anthraquinones	18-31	PHD finger protein 6	Homo sapiens	78-82
31562564-5	2020	This molecule, an anthraquinone derivative named Purpurin, inhibited ~ 50% of PHF6 fibrillization in vitro at equimolar concentration and disassembled pre-formed PHF6 fibrils.	Anthraquinones	18-31	PHD finger protein 6	Homo sapiens	162-166
32328146-4	2020	The purpose of this study was to evaluate the hepatoprotective effects of anthraquinones extract from M. angustifolia root (AEMA) in carbon tetrachloride- (CCl4-) induced liver injury in mice and identify the main bioactive components.	Anthraquinones	74-88	chemokine (C-C motif) ligand 4	Mus musculus	156-160
32355040-0	2020	Structural and thermodynamic analyses of interactions between death-associated protein kinase 1 and anthraquinones.	Anthraquinones	100-114	death associated protein kinase 1	Homo sapiens	62-95
32355040-3	2020	Here, the potent inhibitory activity of the natural anthraquinone purpurin against DAPK1 phosphorylation is shown.	Anthraquinones	52-65	death associated protein kinase 1	Homo sapiens	83-88
31820379-0	2020	Anthraquinone from Edible Fungi Pleurotus ostreatus Protects Human SH-SY5Y Neuroblastoma Cells Against 6-Hydroxydopamine-Induced Cell Death-Preclinical Validation of Gene Knockout Possibilities of PARK7, PINK1, and SNCA1 Using CRISPR SpCas9.	Anthraquinones	0-13	Parkinsonism associated deglycase	Homo sapiens	197-202
31820379-0	2020	Anthraquinone from Edible Fungi Pleurotus ostreatus Protects Human SH-SY5Y Neuroblastoma Cells Against 6-Hydroxydopamine-Induced Cell Death-Preclinical Validation of Gene Knockout Possibilities of PARK7, PINK1, and SNCA1 Using CRISPR SpCas9.	Anthraquinones	0-13	PTEN induced kinase 1	Homo sapiens	204-209
31820379-13	2020	Immunoblot analysis carried out with apoptotic markers showed that cytochrome C and caspase-3 expression increased significantly in anthraquinone-treated cells, whereas 6-OHDA-treated group showed a significant decrease when compared with an experimental control group.	Anthraquinones	132-145	cytochrome c, somatic	Homo sapiens	67-79
31820379-13	2020	Immunoblot analysis carried out with apoptotic markers showed that cytochrome C and caspase-3 expression increased significantly in anthraquinone-treated cells, whereas 6-OHDA-treated group showed a significant decrease when compared with an experimental control group.	Anthraquinones	132-145	caspase 3	Homo sapiens	84-93
32173584-8	2020	Mechanistic studies are summarized, which indicate that flavonoids, terpenoids, and anthranoids can inhibit starch-digesting enzymes, aldose reductase, MAP kinases, NFkappaB, and/or IkappaB kinases implicated in energy metabolism, beta-cells, and immunity.	Anthraquinones	84-95	aldo-keto reductase family 1 member B	Homo sapiens	134-150
32260423-0	2020	Novel Anthraquinone Compounds Inhibit Colon Cancer Cell Proliferation via the Reactive Oxygen Species/JNK Pathway.	Anthraquinones	6-19	mitogen-activated protein kinase 8	Homo sapiens	102-105
32280384-0	2020	Efficient synthesis of 3,6,13,16-tetrasubstituted-tetrabenzo[a,d,j,m]coronenes by selective C-H/C-O arylations of anthraquinone derivatives.	Anthraquinones	114-127	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	92-97
29863900-0	2019	New anthraquinone and eurotinone analogue from the seeds of Senna obtusifolia and their inhibitory effects on human organic anion transporters 1 and 3.	Anthraquinones	4-17	solute carrier family 22 member 6	Homo sapiens	116-150
32053750-2	2020	In this work, we reported a series of anthraquinone functionalized microgels (PNI-xVAQ) with thermo-sensitivity, redox-actuated self-regulating color, size and fluorescent properties, which were easily synthesized via surfactant free emulsion copolymerization (SFEP) with N-isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and N,N"-methylenebisacrylamide (BIS) as the cross-linker in an aqueous solution at 70 oC.	Anthraquinones	38-51	serpin family E member 2	Homo sapiens	78-81
32053750-4	2020	The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback.	Anthraquinones	135-148	serpin family E member 2	Homo sapiens	64-67
32053750-4	2020	The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback.	Anthraquinones	267-280	serpin family E member 2	Homo sapiens	64-67
32053750-4	2020	The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback.	Anthraquinones	267-280	serpin family E member 2	Homo sapiens	64-67
32053750-4	2020	The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback.	Anthraquinones	267-280	serpin family E member 2	Homo sapiens	64-67
32143368-2	2020	We confirmed that physcion (an anthraquinone derivative) induces TNF-alpha production by macrophages and increased the expressions of surface molecules (CD40, CD80, and CD86) and major histocompatibility complex (MHC) II.	Anthraquinones	31-44	tumor necrosis factor	Homo sapiens	65-74
32028185-1	2020	BACKGROUND: Aloe-emodin (AE) is among the primary bioactive anthraquinones present in traditional Chinese medicinal plants such as Rheum palmatum L. Multidrug resistance protein 2 (ABCC2/ MRP2) is an important efflux transporter of substances associated with cellular oxidative stress.	Anthraquinones	60-74	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	149-179
32028185-1	2020	BACKGROUND: Aloe-emodin (AE) is among the primary bioactive anthraquinones present in traditional Chinese medicinal plants such as Rheum palmatum L. Multidrug resistance protein 2 (ABCC2/ MRP2) is an important efflux transporter of substances associated with cellular oxidative stress.	Anthraquinones	60-74	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	181-186
32028185-1	2020	BACKGROUND: Aloe-emodin (AE) is among the primary bioactive anthraquinones present in traditional Chinese medicinal plants such as Rheum palmatum L. Multidrug resistance protein 2 (ABCC2/ MRP2) is an important efflux transporter of substances associated with cellular oxidative stress.	Anthraquinones	60-74	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	188-192
31753697-0	2020	Upregulation of p53 through induction of MDM2 degradation: Amino acid prodrugs of anthraquinone analogs.	Anthraquinones	82-95	tumor protein p53	Homo sapiens	16-19
31753697-0	2020	Upregulation of p53 through induction of MDM2 degradation: Amino acid prodrugs of anthraquinone analogs.	Anthraquinones	82-95	MDM2 proto-oncogene	Homo sapiens	41-45
32280914-6	2020	In silico studies revealed that a hydroxyl group at C1, C3, and C8 and a methyl group at C6 of anthraquinone structure are essential for hD3R agonist and hV1AR antagonist effects, as well as for the H-bond interaction of 1-OH group with Ser192 at a proximity of 2.0 A.	Anthraquinones	95-108	arginine vasopressin receptor 1A	Homo sapiens	154-159
32280914-7	2020	Thus, based on in silico and in vitro results, hV1AR, hD3R, and h5-HT1AR appear to be prime targets of the tested anthraquinones.	Anthraquinones	114-128	arginine vasopressin receptor 1A	Homo sapiens	47-52
31645662-0	2020	Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis.	Anthraquinones	19-32	NLR family, pyrin domain containing 3	Mus musculus	110-115
31254825-3	2019	In this paper, photocatalytic degradation of AQ in the presence of inorganic ions (NO3-, HCO3-, Fe3+) and organic matter (humic acid) was studied with {101} and {010}-TiO2 as sunlight-driven photocatalysts.	Anthraquinones	45-47	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
31450413-4	2019	The function of anthraquinone part is not only to increase molecular mass of the target ions after GGT catalyzed cleavage enabling the report ions appearing in higher m/z region avoiding matrix ion interference, but also to remarkably enhance the report ions ionization efficiency.	Anthraquinones	16-29	inactive glutathione hydrolase 2	Homo sapiens	99-102
31450413-6	2019	Under optimized conditions, when employing an Aq linked methylated-glutathione (Aq-ECA) as the internal standard, the GGT activity amount can be quantified in a linear range of 1-50 U/L with r2 &gt; 0.99.	Anthraquinones	46-48	inactive glutathione hydrolase 2	Homo sapiens	118-121
31322780-6	2019	The selected anthraquinone appears thus as a key tool to investigate the role of UHRF1 in the inheritance of methylation patterns, as well as a starting point for hit-to-lead optimizations.	Anthraquinones	13-26	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	81-86
31429995-4	2019	Some of the BF2 Curs-based photoinitiating systems exhibit much higher efficiencies than the reported anthraquinone derivative Oil Blue N (OBN).	Anthraquinones	102-115	forkhead box G1	Homo sapiens	12-15
31519943-6	2019	Considering the discovered impact of high expression of ALKBH proteins on HNSCC development, we screened for ALKBH blockers among newly synthetized anthraquinone derivatives and demonstrated their potential to support standard anticancer therapy.	Anthraquinones	148-161	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	56-61
31519943-6	2019	Considering the discovered impact of high expression of ALKBH proteins on HNSCC development, we screened for ALKBH blockers among newly synthetized anthraquinone derivatives and demonstrated their potential to support standard anticancer therapy.	Anthraquinones	148-161	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	109-114
31324563-0	2019	Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.	Anthraquinones	59-72	tumor protein p53	Homo sapiens	16-19
31324563-0	2019	Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.	Anthraquinones	59-72	MDM2 proto-oncogene	Homo sapiens	41-45
31324563-1	2019	In a previous study, a novel anthraquinone analog BW-AQ-101 was identified as a potent inducer of MDM2 degradation, leading to upregulation of p53 and apoptosis in cell culture studies.	Anthraquinones	29-42	MDM2 proto-oncogene	Homo sapiens	98-102
31324563-1	2019	In a previous study, a novel anthraquinone analog BW-AQ-101 was identified as a potent inducer of MDM2 degradation, leading to upregulation of p53 and apoptosis in cell culture studies.	Anthraquinones	29-42	tumor protein p53	Homo sapiens	143-146
31207449-0	2019	Anthraquinones from Cassiae semen as thrombin inhibitors: in vitro and in silico studies.	Anthraquinones	0-14	coagulation factor II, thrombin	Homo sapiens	37-45
31207449-6	2019	All these findings suggest that obtusifolin and aurantio-obtusin are strong thrombin inhibitors possessing a unique anthraquinone skeleton, and could be used as lead compounds for the development of new thrombin inhibitors with improved properties.	Anthraquinones	116-129	coagulation factor II, thrombin	Homo sapiens	76-84
30798052-2	2019	Herein, based on our previously reported PGAM1 inhibitor PGMI-004A, we have developed anthraquinone derivatives as novel allosteric PGAM1 inhibitors and the structure-activity relationship (SAR) was investigated.	Anthraquinones	86-99	phosphoglycerate mutase 1	Homo sapiens	132-137
31306451-5	2019	Recently, laccaic acid A (LCA), a highly substituted anthraquinone natural product, was identified as a direct, DNA-competitive inhibitor of DNMT1.	Anthraquinones	53-66	DNA methyltransferase 1	Homo sapiens	141-146
31306451-6	2019	Here, we have successfully screened a small library of simplified anthraquinone compounds for DNMT1 inhibition.	Anthraquinones	66-79	DNA methyltransferase 1	Homo sapiens	94-99
31306451-7	2019	Using an endonuclease-coupled DNA methylation assay, we identified two anthraquinone compounds, each containing an aromatic substituent, that act as direct DNMT1 inhibitors.	Anthraquinones	71-84	DNA methyltransferase 1	Homo sapiens	156-161
31306451-8	2019	These simplified anthraquinone compounds retain the DNA-competitive mechanism of action of LCA and exhibit some selectivity for DNMT1 over DNMT3a.	Anthraquinones	17-30	DNA methyltransferase 1	Homo sapiens	128-133
31306451-8	2019	These simplified anthraquinone compounds retain the DNA-competitive mechanism of action of LCA and exhibit some selectivity for DNMT1 over DNMT3a.	Anthraquinones	17-30	DNA methyltransferase 3 alpha	Homo sapiens	139-145
31306451-10	2019	Collectively, this data indicates that substituted anthraquinone compounds could serve as a novel scaffold for developing DNMT1-specific inhibitors.	Anthraquinones	51-64	DNA methyltransferase 1	Homo sapiens	122-127
30798052-0	2019	Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment.	Anthraquinones	39-52	phosphoglycerate mutase 1	Homo sapiens	79-104
31306451-0	2019	Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors.	Anthraquinones	12-26	DNA methyltransferase 1	Homo sapiens	62-85
31071387-0	2019	Anthraquinone-type inhibitor of alpha-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes.	Anthraquinones	0-13	sucrase-isomaltase	Homo sapiens	32-49
31055607-0	2019	Chrysophanol, an anthraquinone from AST2017-01, possesses the anti-proliferative effect through increasing p53 protein levels in human mast cells.	Anthraquinones	17-30	solute carrier family 17 member 5	Homo sapiens	36-39
30658758-0	2019	Characterization of binding interactions of anthraquinones and bovine beta-lactoglobulin.	Anthraquinones	44-58	beta-lactoglobulin	Bos taurus	70-88
31095348-3	2019	Diacerein, a rhein prodrug and anthraquinone, has been shown to reduce expression of K14 and inhibit IL-1 converting enzyme.	Anthraquinones	31-44	keratin 14	Homo sapiens	85-88
30664170-3	2019	As the epidermal growth factor receptor (EFGR) and HER2 proteins are members of the ErbB family, the present study aimed to determine whether these anthraquinone derivatives exhibit potent antitumour bioactivity due to their inhibition of EGFR protein.	Anthraquinones	148-161	epidermal growth factor receptor	Homo sapiens	7-39
30664170-3	2019	As the epidermal growth factor receptor (EFGR) and HER2 proteins are members of the ErbB family, the present study aimed to determine whether these anthraquinone derivatives exhibit potent antitumour bioactivity due to their inhibition of EGFR protein.	Anthraquinones	148-161	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-55
30664170-3	2019	As the epidermal growth factor receptor (EFGR) and HER2 proteins are members of the ErbB family, the present study aimed to determine whether these anthraquinone derivatives exhibit potent antitumour bioactivity due to their inhibition of EGFR protein.	Anthraquinones	148-161	epidermal growth factor receptor	Homo sapiens	84-88
30664170-3	2019	As the epidermal growth factor receptor (EFGR) and HER2 proteins are members of the ErbB family, the present study aimed to determine whether these anthraquinone derivatives exhibit potent antitumour bioactivity due to their inhibition of EGFR protein.	Anthraquinones	148-161	epidermal growth factor receptor	Homo sapiens	239-243
30623649-2	2019	Structural modifications of hit anthraquinone led to the identification of a new series of allosteric PDK4 inhibitors.	Anthraquinones	32-45	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	102-106
30517764-8	2019	The major SC constituents, in particular three anthraquinones, are able to activate AMPK in HepG2 cells and inhibit Bsep in primary mouse hepatocytes, with emodin showing the strongest activities.	Anthraquinones	47-61	ATP binding cassette subfamily B member 11	Homo sapiens	116-120
30818883-0	2019	Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors.	Anthraquinones	15-28	phosphoglycerate mutase 1	Homo sapiens	42-67
30818883-4	2019	In the meantime, we determined the co-crystal structure of PGAM1 and one of the anthraquinone inhibitors 9i with IC50 value of 0.27 muM.	Anthraquinones	80-93	phosphoglycerate mutase 1	Homo sapiens	59-64
30597327-0	2019	A novel class of anthraquinone-based HDAC6 inhibitors.	Anthraquinones	17-30	histone deacetylase 6	Homo sapiens	37-42
30584840-2	2019	The pivotal Hauser annulation for the anthraquinone core construction was achieved by the fusion of two highly functionalized segments: a cyanophthalide (the AB-ring segment) and a tricyclic quinone monoketal (the DEF-ring segment).	Anthraquinones	38-51	UTP25 small subunit processome component	Homo sapiens	214-217
30960149-2	2019	In this paper, Alizarin Red S (ARS), an electroactive anthraquinone dye, is employed to construct LbL (BPEI/ARS)n films with branched poly(ethylene imine) (BPEI) as the complementary polymer.	Anthraquinones	54-67	secreted LY6/PLAUR domain containing 1	Homo sapiens	31-34
30268824-0	2018	Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties.	Anthraquinones	55-68	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	0-3
30612459-0	2019	Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation.	Anthraquinones	10-23	NLR family pyrin domain containing 3	Homo sapiens	45-50
30399493-2	2019	Our previous study showed that overexpression of the mutant constitutively active Ca2+ independent form of the AtCPK1 gene (AtCPK1-Ca) significantly increased the biosynthesis of anthraquinones and stilbenes in Rubia cordifolia L. and Vitis amurensis Rupr.	Anthraquinones	179-193	calcium dependent protein kinase 1	Arabidopsis thaliana	111-117
30399493-2	2019	Our previous study showed that overexpression of the mutant constitutively active Ca2+ independent form of the AtCPK1 gene (AtCPK1-Ca) significantly increased the biosynthesis of anthraquinones and stilbenes in Rubia cordifolia L. and Vitis amurensis Rupr.	Anthraquinones	179-193	calcium dependent protein kinase 1	Arabidopsis thaliana	124-130
30627049-4	2019	The goals of this study were: to determine the inhibitory potencies of individual anthraquinones and whole RR extract against human liver microsomal CYP1A2/3A4 activity, to predict the content of anthraquinones in RR using the concentration addition (CA) model, and to compare predicted and empirical contents in the same RR sample.	Anthraquinones	82-96	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	149-155
30029193-0	2018	Photoconversion of an anthraquinone derivative in the presence of human serum albumin.	Anthraquinones	22-35	albumin	Homo sapiens	72-85
30510513-0	2018	Anthraquinone Emodin Inhibits Tumor Necrosis Factor Alpha-Induced Calcification of Human Aortic Valve Interstitial Cells via the NF-kappaB Pathway.	Anthraquinones	0-13	tumor necrosis factor	Homo sapiens	30-57
30374498-1	2018	Ruthenium-catalysis enabled the C-5 selective C-H oxygenation of naphthoquinones, and also sets the stage for the site-selective introduction of a hydroxyl group into anthraquinones.	Anthraquinones	167-181	complement C5	Homo sapiens	32-35
30228188-9	2018	Moreover, we report that USP15 is weakly inhibited by the antineoplastic agent mitoxantrone in vitro A USP15-mitoxantrone complex structure disclosed that the anthracenedione interacts with the S1" binding site.	Anthraquinones	159-174	ubiquitin specific peptidase 15	Homo sapiens	25-30
30228188-9	2018	Moreover, we report that USP15 is weakly inhibited by the antineoplastic agent mitoxantrone in vitro A USP15-mitoxantrone complex structure disclosed that the anthracenedione interacts with the S1" binding site.	Anthraquinones	159-174	ubiquitin specific peptidase 15	Homo sapiens	103-108
30370860-0	2019	Hydroxyl Group Difference between Anthraquinone Derivatives Regulate Different Cell Death Pathways via Nucleo-Cytoplasmic Shuttling of p53.	Anthraquinones	34-47	tumor protein p53	Homo sapiens	135-138
30291899-4	2019	Several different scaffolds have been identified as P2Y12 receptor antagonists, including irreversibly acting thienotetrahydropyridines (prodrugs), and reversible competitive antagonists, including adenine nucleotide analogs, piperazinyl-glutamate-quinolines, -pyridines, and -pyrimidines, and anthraquinone derivatives.	Anthraquinones	294-307	purinergic receptor P2Y12	Homo sapiens	52-57
30268824-2	2018	After calculating the optimal interaction parameters 1 with the target, two series of tri-armed ligands based on furan- or thiophene-fused anthraquinone scaffolds were designed and synthesized.	Anthraquinones	139-152	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	86-89
28974158-1	2018	Intermolecular interaction study of human serum albumin (HSA) with two anthraquinones i.e. danthron and quinizarin has been performed through fluorescence, UV-vis and CD spectroscopy along with docking analysis.	Anthraquinones	71-85	albumin	Homo sapiens	42-55
28974158-1	2018	Intermolecular interaction study of human serum albumin (HSA) with two anthraquinones i.e. danthron and quinizarin has been performed through fluorescence, UV-vis and CD spectroscopy along with docking analysis.	Anthraquinones	71-85	albumin	Homo sapiens	57-60
29567181-0	2018	Electrochemical detection of c-reactive protein based on anthraquinone-labeled antibody using a screen-printed graphene electrode.	Anthraquinones	57-70	C-reactive protein	Homo sapiens	29-47
29730698-2	2018	Here, we reported that Klotho is enriched in macrophages and Klotho preservation by Rhein, an anthraquinone derived from medicinal plant rhubarb, attenuates lipopolysaccharide (LPS)-induced acute inflammation essentially via promoting toll-like receptor 4 (TLR4) degradation.	Anthraquinones	94-107	klotho	Mus musculus	23-29
29730698-2	2018	Here, we reported that Klotho is enriched in macrophages and Klotho preservation by Rhein, an anthraquinone derived from medicinal plant rhubarb, attenuates lipopolysaccharide (LPS)-induced acute inflammation essentially via promoting toll-like receptor 4 (TLR4) degradation.	Anthraquinones	94-107	klotho	Mus musculus	61-67
29881660-0	2018	Heliomycin and tetracinomycin D: anthraquinone derivatives with histone deacetylase inhibitory activity from marine sponge-associated Streptomyces sp.	Anthraquinones	33-46	histone deacetylase 9	Homo sapiens	64-83
29576510-1	2018	Structural features from the anticancer prodrug nemorubicin (MMDX) and the DNA-binding molecule DRAQ5  were used to prepare anthraquinone-based compounds, which were assessed for their potential to interrogate cytochrome P450 (CYP) functional activity and localisation.	Anthraquinones	124-137	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	227-230
29804278-0	2018	Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds mediate hepatoprotection via Nrf2-mediated HO-1 activation and MAPK modulation.	Anthraquinones	0-13	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
29804278-0	2018	Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds mediate hepatoprotection via Nrf2-mediated HO-1 activation and MAPK modulation.	Anthraquinones	0-13	mitogen-activated protein kinase 1	Homo sapiens	136-140
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	Anthraquinones	30-43	NFE2 like bZIP transcription factor 2	Homo sapiens	230-234
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	Anthraquinones	30-43	mitogen-activated protein kinase 8	Homo sapiens	268-271
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	Anthraquinones	30-43	mitogen-activated protein kinase 1	Homo sapiens	272-275
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	Anthraquinones	30-43	mitogen-activated protein kinase 1	Homo sapiens	276-280
29216561-0	2018	Design, synthesis and evaluation of an anthraquinone derivative conjugated to myelin basic protein immunodominant (MBP85-99) epitope: Towards selective immunosuppression.	Anthraquinones	39-52	myelin basic protein	Homo sapiens	78-98
29732107-5	2018	Compared with a solid-state mixture of anthraquinone and donor molecules, the evenly distributed donor molecules in the micropores of the MOF resulted in a "solid solution" state and significantly promoted the degree of charge transfer between donors and acceptors.	Anthraquinones	39-52	lysine acetyltransferase 8	Homo sapiens	138-141
29493154-8	2017	In conclusion, the four anthraquinone compounds have an inducing effect on CYP3A4 by PXR, but emodin can directly induce CYP3A4.	Anthraquinones	24-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81
29493154-8	2017	In conclusion, the four anthraquinone compounds have an inducing effect on CYP3A4 by PXR, but emodin can directly induce CYP3A4.	Anthraquinones	24-37	nuclear receptor subfamily 1 group I member 2	Homo sapiens	85-88
28306255-3	2017	Therefore, we developed and optimized P2Y4 receptor antagonists based on an anthraquinone scaffold.	Anthraquinones	76-89	pyrimidinergic receptor P2Y4	Homo sapiens	38-42
28658952-2	2017	The permeability of this ligand shell to a negatively charged anthraquinone derivative (AQ), measured from the yield of electron transfer (eT) from the QD core to AQ, increases as the steric bulk of NR4+ increases (for a given concentration of NR4+).	Anthraquinones	62-75	interleukin 13 receptor subunit alpha 1	Homo sapiens	199-202
28658952-2	2017	The permeability of this ligand shell to a negatively charged anthraquinone derivative (AQ), measured from the yield of electron transfer (eT) from the QD core to AQ, increases as the steric bulk of NR4+ increases (for a given concentration of NR4+).	Anthraquinones	62-75	interleukin 13 receptor subunit alpha 1	Homo sapiens	244-247
28658952-2	2017	The permeability of this ligand shell to a negatively charged anthraquinone derivative (AQ), measured from the yield of electron transfer (eT) from the QD core to AQ, increases as the steric bulk of NR4+ increases (for a given concentration of NR4+).	Anthraquinones	88-90	interleukin 13 receptor subunit alpha 1	Homo sapiens	199-202
28658952-2	2017	The permeability of this ligand shell to a negatively charged anthraquinone derivative (AQ), measured from the yield of electron transfer (eT) from the QD core to AQ, increases as the steric bulk of NR4+ increases (for a given concentration of NR4+).	Anthraquinones	88-90	interleukin 13 receptor subunit alpha 1	Homo sapiens	244-247
28658952-2	2017	The permeability of this ligand shell to a negatively charged anthraquinone derivative (AQ), measured from the yield of electron transfer (eT) from the QD core to AQ, increases as the steric bulk of NR4+ increases (for a given concentration of NR4+).	Anthraquinones	163-165	interleukin 13 receptor subunit alpha 1	Homo sapiens	199-202
27769031-0	2017	Synthesis, SAR and pharmacological characterization of novel anthraquinone cation compounds as potential anticancer agents.	Anthraquinones	61-74	sarcosine dehydrogenase	Homo sapiens	11-14
28024230-0	2017	In silico study of porphyrin-anthraquinone hybrids as CDK2 inhibitor.	Anthraquinones	29-42	cyclin dependent kinase 2	Homo sapiens	54-58
28024230-2	2017	In the present work, a series of porphyrin-anthraquinone hybrids bearing meso-substituents, i.e. either pyridine or pyrazole rings were designed and computationally evaluated for their Cyclin Dependent Kinase-2 (CDK2) inhibitory activity using molecular docking, molecular dynamics simulation, and binding free energy calculation.	Anthraquinones	43-56	cyclin dependent kinase 2	Homo sapiens	185-210
28024230-2	2017	In the present work, a series of porphyrin-anthraquinone hybrids bearing meso-substituents, i.e. either pyridine or pyrazole rings were designed and computationally evaluated for their Cyclin Dependent Kinase-2 (CDK2) inhibitory activity using molecular docking, molecular dynamics simulation, and binding free energy calculation.	Anthraquinones	43-56	cyclin dependent kinase 2	Homo sapiens	212-216
28188065-0	2017	Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone.	Anthraquinones	60-73	monoamine oxidase A	Homo sapiens	24-43
27923643-0	2017	Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway.	Anthraquinones	0-13	Eph receptor B1	Rattus norvegicus	119-122
27923643-0	2017	Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway.	Anthraquinones	0-13	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
27923643-0	2017	Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway.	Anthraquinones	0-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	141-145
28216884-6	2017	All of the isolated compounds were examined for their ability to inhibit IDO activities for a series of anthraquinone derivatives (1-7) isolated from the Aloe extract; the IC50 values of these compounds ranged from 39.41 to 53.93 microM.	Anthraquinones	104-117	indoleamine 2,3-dioxygenase 1	Homo sapiens	73-76
27887844-0	2017	Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation.	Anthraquinones	0-14	insulin	Homo sapiens	49-56
27887844-0	2017	Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation.	Anthraquinones	0-14	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	80-108
27887844-0	2017	Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation.	Anthraquinones	0-14	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	110-114
27887844-6	2017	Taken together, these anthraquinones showed the potential action as insulin mimetic to improve glucose uptake via activation of AMPK.	Anthraquinones	22-36	insulin	Homo sapiens	68-75
27887844-6	2017	Taken together, these anthraquinones showed the potential action as insulin mimetic to improve glucose uptake via activation of AMPK.	Anthraquinones	22-36	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	128-132
28035984-0	2016	Promising Inhibitory Effects of Anthraquinones, Naphthopyrone, and Naphthalene Glycosides, from Cassia obtusifolia on alpha-Glucosidase and Human Protein Tyrosine Phosphatases 1B.	Anthraquinones	32-46	sucrase-isomaltase	Homo sapiens	118-135
28035984-2	2016	Among them, anthraquinones emodin and alaternin exhibited the highest inhibitory activities on PTP1B and alpha-glucosidase, respectively.	Anthraquinones	12-26	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	95-100
28035984-2	2016	Among them, anthraquinones emodin and alaternin exhibited the highest inhibitory activities on PTP1B and alpha-glucosidase, respectively.	Anthraquinones	12-26	sucrase-isomaltase	Homo sapiens	105-122
27633141-0	2016	The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes.	Anthraquinones	12-26	peptidylprolyl isomerase G	Homo sapiens	111-114
27633141-6	2016	Additionally, five anthraquinones from R. palmatum could inhibit phase I and II metabolism of Mel with a mixed inhibition kinetic model based on the mechanism of inhibiting human CYP1A1, 1A2, and SULT1A1.	Anthraquinones	19-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	179-185
27633141-6	2016	Additionally, five anthraquinones from R. palmatum could inhibit phase I and II metabolism of Mel with a mixed inhibition kinetic model based on the mechanism of inhibiting human CYP1A1, 1A2, and SULT1A1.	Anthraquinones	19-33	sulfotransferase family 1A member 1	Homo sapiens	196-203
29093981-6	2017	The developed method showed good linearity in 0.012-1.800 mug mL-1 for the five anthraquinones with correlation coefficients more than 0.9993.	Anthraquinones	80-94	L1 cell adhesion molecule	Mus musculus	62-66
27799436-3	2016	From the Raman spectroscopic data, it was possible to identify organic compounds such as anthraquinone and copal resin, which were empirically used as materia medica in the eighteenth century to treat shipboard diseases; it seems very likely, therefore, that the wooden chest belonged to the barber-surgeon on the ship.	Anthraquinones	89-102	inositol polyphosphate-5-phosphatase D	Homo sapiens	201-205
28216884-10	2017	All of the isolated compounds were examined for their ability to inhibit indoleamine 2, 3-dioxygenase (IDO) activities for a series of anthraquinone derivatives (1-7) isolated from the Aloe extract.	Anthraquinones	135-148	indoleamine 2,3-dioxygenase 1	Homo sapiens	73-101
28216884-10	2017	All of the isolated compounds were examined for their ability to inhibit indoleamine 2, 3-dioxygenase (IDO) activities for a series of anthraquinone derivatives (1-7) isolated from the Aloe extract.	Anthraquinones	135-148	indoleamine 2,3-dioxygenase 1	Homo sapiens	103-106
27093247-0	2016	Inhibition of Nitric Oxide Production in LPS-Stimulated RAW 264.7 Macrophages and 15-LOX Activity by Anthraquinones from Pentas schimperi.	Anthraquinones	101-115	arachidonate 15-lipoxygenase	Mus musculus	82-88
27251124-0	2016	Increase of anthraquinone content in Rubia cordifolia cells transformed by native and constitutively active forms of the AtCPK1 gene.	Anthraquinones	12-25	calcium dependent protein kinase 1	Arabidopsis thaliana	121-127
27427516-3	2016	We describe a unique survivin-associated adaptive response in which increased radiation resistance or sensitization of cells can be induced by exposure to 5mGy or to the reactive oxygen species (ROS) generating drug Emodin (1,3,8-trihydroxy-6-methylanthraquinone), a naturally occurring anthraquinone.	Anthraquinones	249-262	baculoviral IAP repeat-containing 5	Mus musculus	21-29
27251124-1	2016	KEY MESSAGE: Overexpression of both native and mutant forms of AtCPK1 in Rubia cordifolia cells increased anthraquinone production and transcript abundance of the RcIPPI, RcOSBL, RcOSBS , and RcICS genes to different extents.	Anthraquinones	106-119	calcium dependent protein kinase 1	Arabidopsis thaliana	63-69
26698630-0	2016	Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid.	Anthraquinones	123-136	MIR7-3 host gene	Homo sapiens	86-91
27251124-4	2016	In this study, we compared the effect of heterologous expression of two forms of the Arabidopsis AtCPK1 gene, native and constitutively active (Ca(2+)-independent), on anthraquinone production in transgenic Rubia cordifolia cells.	Anthraquinones	168-181	calcium dependent protein kinase 1	Arabidopsis thaliana	97-103
27251124-5	2016	Significant qualitative and quantitative differences were found in the content of anthraquinone derivatives in control and AtCPK1-transgenic calli.	Anthraquinones	82-95	calcium dependent protein kinase 1	Arabidopsis thaliana	123-129
27251124-6	2016	Expression of the AtCPK1 gene increased anthraquinone production by 3 and 12 times for native and constitutively active forms, respectively, compared with control cells.	Anthraquinones	40-53	calcium dependent protein kinase 1	Arabidopsis thaliana	18-24
27251124-9	2016	The results suggest that both native and constitutively active AtCPK1 forms induced anthraquinone accumulation at the logarithmic growth stage via enhancement of expression of genes involved in the metabolism of anthraquinones or their regulatory mechanisms.	Anthraquinones	84-97	calcium dependent protein kinase 1	Arabidopsis thaliana	63-69
27251124-9	2016	The results suggest that both native and constitutively active AtCPK1 forms induced anthraquinone accumulation at the logarithmic growth stage via enhancement of expression of genes involved in the metabolism of anthraquinones or their regulatory mechanisms.	Anthraquinones	212-226	calcium dependent protein kinase 1	Arabidopsis thaliana	63-69
27490539-1	2016	In this research, we firstly demonstrated that physcion, an anthraquinone derivative, specifically increased the expression of the human alpha2,8-sialyltransferase (hST8Sia VI) gene in SK-N-BE(2)-C human neuroblastoma cells.	Anthraquinones	60-73	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	Homo sapiens	165-175
27274078-0	2016	Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization.	Anthraquinones	93-106	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	50-79
26942875-7	2016	Besides c-KIT, the transcriptional analysis covered a panel of oncogenes known to possess G4 in their promoters.From these studies, an anthraquinone derivative (AQ1) was found to efficiently downregulate c-KIT mRNA and protein in both cell lines.	Anthraquinones	135-148	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	8-13
26942875-7	2016	Besides c-KIT, the transcriptional analysis covered a panel of oncogenes known to possess G4 in their promoters.From these studies, an anthraquinone derivative (AQ1) was found to efficiently downregulate c-KIT mRNA and protein in both cell lines.	Anthraquinones	135-148	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	204-209
27044842-0	2016	The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest.	Anthraquinones	10-23	tumor protein p53	Homo sapiens	82-85
25673059-0	2015	The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer.	Anthraquinones	4-17	RUNX family transcription factor 2	Homo sapiens	96-101
26585176-0	2016	An anthraquinone derivative from Luffa acutangula induces apoptosis in human lung cancer cell line NCI-H460 through p53-dependent pathway.	Anthraquinones	3-16	tumor protein p53	Homo sapiens	116-119
26372074-0	2015	Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe.	Anthraquinones	49-62	epoxide hydrolase 2	Homo sapiens	0-25
26312416-2	2015	Pulsed laser excitation at 532 nm led to the formation of charge-separated states of the type Ru(-)-OTA(+) and AQ(-)-Ru-OTA(+) with lifetimes of &lt;=10 ns and 2.4 mus, respectively, in de-aerated CH3CN at 25  C. Upon addition of Sc(OTf)3, very long-lived photoproducts were observed.	Anthraquinones	111-113	POU class 5 homeobox 1	Homo sapiens	230-238
26169035-0	2015	BME, a novel compound of anthraquinone, down regulated P-glycoprotein expression in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells via generation of reactive oxygen species.	Anthraquinones	25-38	ATP binding cassette subfamily B member 1	Homo sapiens	55-69
26169035-3	2015	The present study revealed that BME, a novel compound of anthraquinone, elevated intracellular accumulation of the P-gp substrates and reduced concentration resulting in 50% inhibition of cell growth (IC50) values for doxorubicin (DOX) in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.	Anthraquinones	57-70	ATP binding cassette subfamily B member 1	Homo sapiens	115-119
26194851-6	2015	Ureas, sulfonylureas, sulfonamides, anthraquinones and glutamic acid piperazines docked readily to the antagonist-bound P2Y12R.	Anthraquinones	36-50	purinergic receptor P2Y12	Homo sapiens	120-126
25823617-7	2015	Experimental results revealed anthraquinone ARDP0006 (compound 5) to be the most potent inhibitor which reduced dengue viral titer by more than 1 log PFU/mL at 1 muM in our cell-based assays involving HuH-7 and K562 cell lines, suggesting that its scaffold could serve as a lead for further medicinal chemistry studies.	Anthraquinones	30-43	MIR7-3 host gene	Homo sapiens	201-206
25053177-7	2015	Initially, we found that the natural anthranoid, 4,5-dihydroxyanthraquinone-2-carboxylic acid (rhein), and its highly water-soluble tri-potassium salt form (K-rhein) are inhibitors of CD38 enzymatic (nicotinamide adenine dinucleotide glycohydrolase) activity (IC50 = 1.24 and 0.84 muM, respectively, for recombinant mouse CD38).	Anthraquinones	37-47	CD38 antigen	Mus musculus	184-188
25053177-7	2015	Initially, we found that the natural anthranoid, 4,5-dihydroxyanthraquinone-2-carboxylic acid (rhein), and its highly water-soluble tri-potassium salt form (K-rhein) are inhibitors of CD38 enzymatic (nicotinamide adenine dinucleotide glycohydrolase) activity (IC50 = 1.24 and 0.84 muM, respectively, for recombinant mouse CD38).	Anthraquinones	37-47	CD38 antigen	Mus musculus	322-326
25189099-4	2015	To enable multiplexing, IFN-gamma and TNF-alpha aptamers were labeled with anthraquinone (AQ) and methylene blue (MB) redox reporters respectively.	Anthraquinones	75-88	interferon gamma	Homo sapiens	24-33
25324174-5	2015	Furthermore, an anthraquinone BH3 mimetic, compound 6, was identified to be the first small molecule to that induces endogenous apoptosis in melanoma cells by directly binding Bcl-2, Mcl-1, and pMcl-1 and disrupting the heterodimers of these proteins.	Anthraquinones	16-29	BCL2 apoptosis regulator	Homo sapiens	176-181
25324174-5	2015	Furthermore, an anthraquinone BH3 mimetic, compound 6, was identified to be the first small molecule to that induces endogenous apoptosis in melanoma cells by directly binding Bcl-2, Mcl-1, and pMcl-1 and disrupting the heterodimers of these proteins.	Anthraquinones	16-29	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	183-188
25189099-4	2015	To enable multiplexing, IFN-gamma and TNF-alpha aptamers were labeled with anthraquinone (AQ) and methylene blue (MB) redox reporters respectively.	Anthraquinones	75-88	tumor necrosis factor	Homo sapiens	38-47
25189099-4	2015	To enable multiplexing, IFN-gamma and TNF-alpha aptamers were labeled with anthraquinone (AQ) and methylene blue (MB) redox reporters respectively.	Anthraquinones	90-92	interferon gamma	Homo sapiens	24-33
25189099-4	2015	To enable multiplexing, IFN-gamma and TNF-alpha aptamers were labeled with anthraquinone (AQ) and methylene blue (MB) redox reporters respectively.	Anthraquinones	90-92	tumor necrosis factor	Homo sapiens	38-47
26133709-0	2015	Time-Dependent Inhibition of hOAT1 and hOAT3 by Anthraquinones.	Anthraquinones	48-62	solute carrier family 22 member 6	Homo sapiens	29-34
26133709-0	2015	Time-Dependent Inhibition of hOAT1 and hOAT3 by Anthraquinones.	Anthraquinones	48-62	solute carrier family 22 member 8	Homo sapiens	39-44
26133709-1	2015	We previously showed that anthraquinones (including rhein, emodin, aloe-emodin, chrysophanol and physcion) were inhibitors of human organic anion transporter 1 (hOAT1) and hOAT3, causing transporter-mediated drug-drug interactions in rats.	Anthraquinones	26-40	solute carrier family 22 member 6	Homo sapiens	132-159
26133709-1	2015	We previously showed that anthraquinones (including rhein, emodin, aloe-emodin, chrysophanol and physcion) were inhibitors of human organic anion transporter 1 (hOAT1) and hOAT3, causing transporter-mediated drug-drug interactions in rats.	Anthraquinones	26-40	solute carrier family 22 member 6	Homo sapiens	161-166
26133709-1	2015	We previously showed that anthraquinones (including rhein, emodin, aloe-emodin, chrysophanol and physcion) were inhibitors of human organic anion transporter 1 (hOAT1) and hOAT3, causing transporter-mediated drug-drug interactions in rats.	Anthraquinones	26-40	solute carrier family 22 member 8	Homo sapiens	172-177
26133709-2	2015	In this study, the time-dependent inhibition (TDI) of hOAT1 and hOAT3 by anthraquinones was investigated.	Anthraquinones	73-87	solute carrier family 22 member 6	Homo sapiens	54-59
26133709-2	2015	In this study, the time-dependent inhibition (TDI) of hOAT1 and hOAT3 by anthraquinones was investigated.	Anthraquinones	73-87	solute carrier family 22 member 8	Homo sapiens	64-69
26133709-7	2015	In conclusion, our results suggest that some anthraquinones contribute to the TDI of hOAT1 and hOAT3.	Anthraquinones	45-59	solute carrier family 22 member 6	Homo sapiens	85-90
26133709-7	2015	In conclusion, our results suggest that some anthraquinones contribute to the TDI of hOAT1 and hOAT3.	Anthraquinones	45-59	solute carrier family 22 member 8	Homo sapiens	95-100
26133709-8	2015	An inhibition study without the preincubation procedure may underestimate the inhibitory potential of anthraquinones against hOAT1 and hOAT3.	Anthraquinones	102-116	solute carrier family 22 member 6	Homo sapiens	125-130
26133709-8	2015	An inhibition study without the preincubation procedure may underestimate the inhibitory potential of anthraquinones against hOAT1 and hOAT3.	Anthraquinones	102-116	solute carrier family 22 member 8	Homo sapiens	135-140
25091695-0	2014	PPemd26, an anthraquinone derivative, suppresses angiogenesis via inhibiting VEGFR2 signalling.	Anthraquinones	12-25	kinase insert domain receptor	Homo sapiens	77-83
25431950-3	2014	We next developed a small molecule, NSC745885, derived from natural anthraquinone emodin, which down-regulated EZH2 via proteasome-mediated degradation.	Anthraquinones	68-81	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	111-115
24223970-0	2013	Inhibiting AKT phosphorylation employing non-cytotoxic anthraquinones ameliorates TH2 mediated allergic airways disease and rhinovirus exacerbation.	Anthraquinones	55-69	thymoma viral proto-oncogene 1	Mus musculus	11-14
25611347-1	2015	Quinofuracins A-E, novel anthraquinone derivatives containing beta-D-galactofuranose that were isolated from the fungus Staphylotrichum boninense PF1444, induced p53-dependent cell death in human tumor cells.	Anthraquinones	25-38	tumor protein p53	Homo sapiens	162-165
25177847-4	2014	The concentrations of anthranoids in serum were determined by HPLC method before and after hydrolysis with sulfatase and beta-glucuronidase.	Anthraquinones	22-33	glucuronidase, beta	Rattus norvegicus	121-139
24853816-5	2014	The DNA sequence dependence of p53 oxidative dissociation was examined by electrophoretic mobility shift assays using oligonucleotides containing both synthetic and human p53 consensus sequences with an appended photooxidant, anthraquinone.	Anthraquinones	226-239	tumor protein p53	Homo sapiens	31-34
24685584-0	2014	Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug-drug interaction in rats.	Anthraquinones	20-34	solute carrier family 22 member 6	Homo sapiens	59-86
24685584-0	2014	Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug-drug interaction in rats.	Anthraquinones	20-34	solute carrier family 22 member 6	Homo sapiens	88-95
24685584-0	2014	Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug-drug interaction in rats.	Anthraquinones	20-34	solute carrier family 22 member 8	Homo sapiens	104-111
24685584-3	2014	MATERIALS AND METHODS: Here we studied the interaction of five anthraquinone derivatives with human renal organic anion transporter 1 (hOAT1) and hOAT3 stably expressed in cells, and interaction of rhein or rhubarb extract (RE) with furosemide (FS, substrate of OATs) in rats.	Anthraquinones	63-76	solute carrier family 22 member 6	Homo sapiens	100-133
24685584-3	2014	MATERIALS AND METHODS: Here we studied the interaction of five anthraquinone derivatives with human renal organic anion transporter 1 (hOAT1) and hOAT3 stably expressed in cells, and interaction of rhein or rhubarb extract (RE) with furosemide (FS, substrate of OATs) in rats.	Anthraquinones	63-76	solute carrier family 22 member 6	Homo sapiens	135-140
24685584-3	2014	MATERIALS AND METHODS: Here we studied the interaction of five anthraquinone derivatives with human renal organic anion transporter 1 (hOAT1) and hOAT3 stably expressed in cells, and interaction of rhein or rhubarb extract (RE) with furosemide (FS, substrate of OATs) in rats.	Anthraquinones	63-76	solute carrier family 22 member 8	Homo sapiens	146-151
24685584-9	2014	CONCLUSIONS: These findings suggested that five anthraquinones inhibited hOAT1 and hOAT3, but these compounds were not transported by hOAT1 or hOAT3.	Anthraquinones	48-62	solute carrier family 22 member 6	Homo sapiens	73-78
24685584-9	2014	CONCLUSIONS: These findings suggested that five anthraquinones inhibited hOAT1 and hOAT3, but these compounds were not transported by hOAT1 or hOAT3.	Anthraquinones	48-62	solute carrier family 22 member 8	Homo sapiens	83-88
25652235-5	2015	Diacerein, a semi-synthetic anthraquinone derivative, inhibits the interleukin-1-beta (IL-1beta) cytokine which, according to animal studies, plays a key role in the pathogenesis of OA.	Anthraquinones	28-41	interleukin 1 beta	Homo sapiens	67-85
25652235-5	2015	Diacerein, a semi-synthetic anthraquinone derivative, inhibits the interleukin-1-beta (IL-1beta) cytokine which, according to animal studies, plays a key role in the pathogenesis of OA.	Anthraquinones	28-41	interleukin 1 beta	Homo sapiens	87-95
24867631-3	2014	Of note, ABC transporters are capable of effluxing several classes of drugs that are clinical standards, including the anthracyclines such as doxorubicin, as well as anthracenediones such as mitoxantrone.	Anthraquinones	166-182	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	9-12
25434113-9	2014	The coupling reagent chains and anthraquinone rings in ESP offered a structural basis for hydrophobic interaction.	Anthraquinones	32-45	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	55-58
24515444-3	2014	Diacerein is an anthraquinone synthesised in 1980 that interferes with interleukin-1, an inflammatory mediator.	Anthraquinones	16-29	interleukin 1 alpha	Homo sapiens	71-84
24176397-0	2013	Antiproliferative activities and SAR studies of substituted anthraquinones and 1,4-naphthoquinones.	Anthraquinones	60-74	sarcosine dehydrogenase	Homo sapiens	33-36
24176397-2	2013	The search for STAT3 inhibitors led to the discoveries of LLLs 3 and 12, which are substituted anthraquinones.	Anthraquinones	95-109	signal transducer and activator of transcription 3	Homo sapiens	15-20
24223970-0	2013	Inhibiting AKT phosphorylation employing non-cytotoxic anthraquinones ameliorates TH2 mediated allergic airways disease and rhinovirus exacerbation.	Anthraquinones	55-69	heart and neural crest derivatives expressed 2	Mus musculus	82-85
24223970-3	2013	Anthraquinone derivatives have been shown to reduce PI3K-mediated AKT phosphorylation in-vitro.	Anthraquinones	0-13	thymoma viral proto-oncogene 1	Mus musculus	66-69
24223970-7	2013	RESULTS: Anthraquinone treatment reduced AKT phosphorylation, hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression, and ameliorated allergen- and RV-induced airways hyprereactivity, neutrophilic and eosinophilic inflammation, cytokine/chemokine expression, mucus hypersecretion, and expression of TH2 proteins in the airways.	Anthraquinones	9-22	thymoma viral proto-oncogene 1	Mus musculus	41-44
24223970-7	2013	RESULTS: Anthraquinone treatment reduced AKT phosphorylation, hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression, and ameliorated allergen- and RV-induced airways hyprereactivity, neutrophilic and eosinophilic inflammation, cytokine/chemokine expression, mucus hypersecretion, and expression of TH2 proteins in the airways.	Anthraquinones	9-22	hypoxia inducible factor 1, alpha subunit	Mus musculus	62-93
24223970-7	2013	RESULTS: Anthraquinone treatment reduced AKT phosphorylation, hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression, and ameliorated allergen- and RV-induced airways hyprereactivity, neutrophilic and eosinophilic inflammation, cytokine/chemokine expression, mucus hypersecretion, and expression of TH2 proteins in the airways.	Anthraquinones	9-22	heart and neural crest derivatives expressed 2	Mus musculus	326-329
24223970-9	2013	CONCLUSION: Non-cytotoxic anthraquinone derivatives may be of therapeutic benefit for the treatment of severe and RV-induced asthma by blocking pro-inflammatory pathways regulated by PI3K/AKT.	Anthraquinones	26-39	thymoma viral proto-oncogene 1	Mus musculus	188-191
24095762-1	2013	Based on our previous discovery of an anthraquinone scaffold mimicking two faces of Bim alpha-helix, we derived a quinazolone scaffold through structure simplification and optimization.	Anthraquinones	38-51	BCL2 like 11	Homo sapiens	84-87
23523942-3	2013	In this study, an attempt was made to investigate the interaction between stilbene glucosides and the anthraquinones contained in Radix Polygoni Multiflori (RPM) and to explore the interaction"s mechanism from the perspective of UDP-glucuronosyltransferase (UGT) regulation.	Anthraquinones	102-116	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	258-261
23700228-0	2013	An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.	Anthraquinones	3-16	TNF superfamily member 10	Homo sapiens	81-86
23218603-3	2013	Diacerein is an anthraquinone derivative with a marked disease modifying effect on OA owing to IL-1 beta inhibition.	Anthraquinones	16-29	interleukin 1 beta	Rattus norvegicus	95-104
24900685-0	2013	Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway.	Anthraquinones	0-13	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	50-55
24900685-2	2013	Via integration of computational and experimental studies, anthraquinone derivatives were identified for the first time as potent c-Met kinase inhibitors in this research.	Anthraquinones	59-72	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	130-135
24900685-4	2013	However, anthraquinone derivatives exclusively suppressed c-Met phosphorylation stimulated by HGF in A549 cells, indicating that the compounds possess the ability to block the extracellular HGF-dependent pathway.	Anthraquinones	9-22	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	58-63
24900685-4	2013	However, anthraquinone derivatives exclusively suppressed c-Met phosphorylation stimulated by HGF in A549 cells, indicating that the compounds possess the ability to block the extracellular HGF-dependent pathway.	Anthraquinones	9-22	hepatocyte growth factor	Homo sapiens	94-97
24900685-4	2013	However, anthraquinone derivatives exclusively suppressed c-Met phosphorylation stimulated by HGF in A549 cells, indicating that the compounds possess the ability to block the extracellular HGF-dependent pathway.	Anthraquinones	9-22	hepatocyte growth factor	Homo sapiens	190-193
23174748-6	2013	Five anthraquinones were tested to determine their inhibitory activities on NO production and the protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).	Anthraquinones	5-19	nitric oxide synthase 2	Homo sapiens	162-166
23472074-3	2013	In the present report, we investigated an anthraquinone derivative, emodin for its ability to affect CXCR4 expression as well as function in HCC cells.	Anthraquinones	42-55	C-X-C motif chemokine receptor 4	Homo sapiens	101-106
23451039-2	2013	The purpose of this work is to evaluate anticancer activities of anthraquinone-derived tricyclic and tetracyclic small molecules and their structure-activity relationships with PARP-1 inhibition in non-small cell lung cancer (NSCLC) and NSCLC-overexpressing Oct4 and Nanog clone, which show high-expression of PARP-1 and more resistance to anticancer drug.	Anthraquinones	65-78	poly(ADP-ribose) polymerase 1	Homo sapiens	310-316
23174748-0	2013	Anti-inflammatory properties of anthraquinones and their relationship with the regulation of P-glycoprotein function and expression.	Anthraquinones	32-46	ATP binding cassette subfamily B member 1	Homo sapiens	93-107
23174748-6	2013	Five anthraquinones were tested to determine their inhibitory activities on NO production and the protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).	Anthraquinones	5-19	nitric oxide synthase 2	Homo sapiens	129-160
22897821-3	2012	Recently, knowledge about diacerhein, an anthraquinone drug with powerful antiinflammatory properties, revealed that this drug improves insulin sensitivity, mediated by the reversal of chronic subclinical inflammation.	Anthraquinones	41-54	insulin	Homo sapiens	136-143
23451039-0	2013	New approaches of PARP-1 inhibitors in human lung cancer cells and cancer stem-like cells by some selected anthraquinone-derived small molecules.	Anthraquinones	107-120	poly(ADP-ribose) polymerase 1	Homo sapiens	18-24
23451039-2	2013	The purpose of this work is to evaluate anticancer activities of anthraquinone-derived tricyclic and tetracyclic small molecules and their structure-activity relationships with PARP-1 inhibition in non-small cell lung cancer (NSCLC) and NSCLC-overexpressing Oct4 and Nanog clone, which show high-expression of PARP-1 and more resistance to anticancer drug.	Anthraquinones	65-78	poly(ADP-ribose) polymerase 1	Homo sapiens	177-183
23451039-2	2013	The purpose of this work is to evaluate anticancer activities of anthraquinone-derived tricyclic and tetracyclic small molecules and their structure-activity relationships with PARP-1 inhibition in non-small cell lung cancer (NSCLC) and NSCLC-overexpressing Oct4 and Nanog clone, which show high-expression of PARP-1 and more resistance to anticancer drug.	Anthraquinones	65-78	POU class 5 homeobox 1	Homo sapiens	258-262
22963438-3	2012	Only a few non-drug-like antagonists such as the suramin derivatives NF449 and NF770 and the anthraquinone derivative PSB-1011 are available as pharmacological tools to block the P2X1 and P2X2 receptors, respectively.	Anthraquinones	93-106	purinergic receptor P2X 1	Rattus norvegicus	179-183
22418579-4	2012	The Cibacron Blue molecule was stabilized by four hydrogen bonds and pi-pi stacking between the anthraquinone ring and Trp104, the ceiling of the active site H-PGDS pocket.	Anthraquinones	96-109	hematopoietic prostaglandin D synthase	Homo sapiens	158-164
22296882-0	2012	Human serum albumin stability and toxicity of anthraquinone dye alizarin complexone: an albumin-dye model.	Anthraquinones	46-59	albumin	Homo sapiens	6-19
22296882-1	2012	The complexation between the primary vector of ligands in blood plasma, human serum albumin (HSA) and a toxic anthraquinone dye alizarin complexone, was unmasked by means of circular dichroism (CD), molecular modeling, steady state and time-resolved fluorescence, and UV/vis absorption measurements.	Anthraquinones	110-123	albumin	Homo sapiens	78-91
22690138-0	2012	A marine anthraquinone SZ-685C overrides adriamycin-resistance in breast cancer cells through suppressing Akt signaling.	Anthraquinones	9-22	AKT serine/threonine kinase 1	Homo sapiens	106-109
21874304-0	2012	Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy.	Anthraquinones	43-56	CD34 molecule	Homo sapiens	12-16
22198116-0	2012	Anthraquinone antitumour agents, doxorubicin, pirarubicin and benzoperimidine BP1, trigger caspase-3/caspase-8-dependent apoptosis of leukaemia sensitive HL60 and resistant HL60/VINC and HL60/DOX cells.	Anthraquinones	0-13	BP1	Homo sapiens	78-81
22198116-0	2012	Anthraquinone antitumour agents, doxorubicin, pirarubicin and benzoperimidine BP1, trigger caspase-3/caspase-8-dependent apoptosis of leukaemia sensitive HL60 and resistant HL60/VINC and HL60/DOX cells.	Anthraquinones	0-13	caspase 3	Homo sapiens	91-100
22198116-0	2012	Anthraquinone antitumour agents, doxorubicin, pirarubicin and benzoperimidine BP1, trigger caspase-3/caspase-8-dependent apoptosis of leukaemia sensitive HL60 and resistant HL60/VINC and HL60/DOX cells.	Anthraquinones	0-13	caspase 8	Homo sapiens	101-110
22198116-0	2012	Anthraquinone antitumour agents, doxorubicin, pirarubicin and benzoperimidine BP1, trigger caspase-3/caspase-8-dependent apoptosis of leukaemia sensitive HL60 and resistant HL60/VINC and HL60/DOX cells.	Anthraquinones	0-13	nuclear paraspeckle assembly transcript 1	Homo sapiens	178-182
22198116-3	2012	Interestingly, it was seen that HL60/VINC cells were more susceptible to undergo caspase-3/caspase-8-dependent apoptosis induced by the studied anthraquinone compounds compared with HL60 and HL60/DOX cells.	Anthraquinones	144-157	nuclear paraspeckle assembly transcript 1	Homo sapiens	37-41
22198116-3	2012	Interestingly, it was seen that HL60/VINC cells were more susceptible to undergo caspase-3/caspase-8-dependent apoptosis induced by the studied anthraquinone compounds compared with HL60 and HL60/DOX cells.	Anthraquinones	144-157	caspase 3	Homo sapiens	81-90
22198116-3	2012	Interestingly, it was seen that HL60/VINC cells were more susceptible to undergo caspase-3/caspase-8-dependent apoptosis induced by the studied anthraquinone compounds compared with HL60 and HL60/DOX cells.	Anthraquinones	144-157	caspase 8	Homo sapiens	91-100
22205152-0	2012	Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells.	Anthraquinones	41-54	cytochrome p450 oxidoreductase	Homo sapiens	134-165
22205152-1	2012	The aim of this study was to examine the role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase (CPR) and determine the impact of this activation on increasing the activity especially with regard to multidrug resistant (MDR) tumour cells.	Anthraquinones	82-95	cytochrome p450 oxidoreductase	Homo sapiens	181-206
22205152-1	2012	The aim of this study was to examine the role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase (CPR) and determine the impact of this activation on increasing the activity especially with regard to multidrug resistant (MDR) tumour cells.	Anthraquinones	82-95	cytochrome p450 oxidoreductase	Homo sapiens	208-211
22205152-2	2012	It was found that at a high NADPH concentration (500 mumol/l), the anthracenedione agent ametantrone, with an unmodified quinone structure, was susceptible to CPR-dependent reductive activation.	Anthraquinones	67-82	cytochrome p450 oxidoreductase	Homo sapiens	159-162
22205152-4	2012	This suggests that the presence of a modified quinone function is the structural factor excluding reductive activation of antitumour anthraquinone derivatives and analogues by CPR.	Anthraquinones	133-146	cytochrome p450 oxidoreductase	Homo sapiens	176-179
22205152-5	2012	In the second part of the work, the ability of antitumour anthraquinone derivatives and analogues to inhibit the growth of the human promyelocytic, sensitive leukaemia HL60 cell line as well as its MDR sublines exhibiting two different phenotypes of MDR related to the overexpression of P-glycoprotein (HL60/VINC) or MRP1 (HL60/DOX) was studied in the presence of exogenously added CPR.	Anthraquinones	58-71	nuclear paraspeckle assembly transcript 1	Homo sapiens	308-312
22205152-5	2012	In the second part of the work, the ability of antitumour anthraquinone derivatives and analogues to inhibit the growth of the human promyelocytic, sensitive leukaemia HL60 cell line as well as its MDR sublines exhibiting two different phenotypes of MDR related to the overexpression of P-glycoprotein (HL60/VINC) or MRP1 (HL60/DOX) was studied in the presence of exogenously added CPR.	Anthraquinones	58-71	ATP binding cassette subfamily C member 1	Homo sapiens	317-321
22205152-5	2012	In the second part of the work, the ability of antitumour anthraquinone derivatives and analogues to inhibit the growth of the human promyelocytic, sensitive leukaemia HL60 cell line as well as its MDR sublines exhibiting two different phenotypes of MDR related to the overexpression of P-glycoprotein (HL60/VINC) or MRP1 (HL60/DOX) was studied in the presence of exogenously added CPR.	Anthraquinones	58-71	cytochrome p450 oxidoreductase	Homo sapiens	382-385
21874304-3	2012	Here, employing the CD34(+)/CD14(+) AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of CD34(+) DC precursors into functional antigen-presenting cells (APC) in a three-day protocol.	Anthraquinones	109-122	CD34 molecule	Homo sapiens	20-24
21874304-3	2012	Here, employing the CD34(+)/CD14(+) AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of CD34(+) DC precursors into functional antigen-presenting cells (APC) in a three-day protocol.	Anthraquinones	109-122	CD14 molecule	Homo sapiens	28-32
21874304-3	2012	Here, employing the CD34(+)/CD14(+) AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of CD34(+) DC precursors into functional antigen-presenting cells (APC) in a three-day protocol.	Anthraquinones	109-122	CD34 molecule	Homo sapiens	249-253
21874304-3	2012	Here, employing the CD34(+)/CD14(+) AML-derived human DC progenitor cell line MUTZ3, we show that cytostatic anthraquinone-derivatives (i.e., the anthracenedione mitoxantrone and the related anthracyclin doxorubicin) induce rapid differentiation of CD34(+) DC precursors into functional antigen-presenting cells (APC) in a three-day protocol.	Anthraquinones	146-161	CD34 molecule	Homo sapiens	249-253
22509587-1	2012	Laccase extracted from the Amillariella mellea fermentation catalytic decolored on two common anthraquinone dyes: Reactive Brilliant Blue KN-R and Reactive Brilliant Blue X-BR which is broadly used in the printing and dyeing industry and obtained the optimal catalytic decolorizing conditions.	Anthraquinones	94-107	RE1 silencing transcription factor	Homo sapiens	171-175
22137788-2	2012	Therefore, anthraquinone derivatives were screened to identify a potent phosphatase inhibitor against the phosphatase of regenerating liver-3 (PRL-3).	Anthraquinones	11-24	protein tyrosine phosphatase 4A3	Homo sapiens	106-141
22137788-2	2012	Therefore, anthraquinone derivatives were screened to identify a potent phosphatase inhibitor against the phosphatase of regenerating liver-3 (PRL-3).	Anthraquinones	11-24	protein tyrosine phosphatase 4A3	Homo sapiens	143-148
21328322-2	2011	In this study, we investigated the effect of heterologous expression of the Arabidopsis CDPK gene, AtCPK1, on anthraquinone production in transgenic Rubia cordifolia cells.	Anthraquinones	110-123	calcium dependent protein kinase 1	Arabidopsis thaliana	99-105
22454693-4	2012	Catenarin and/or its anthraquinone analogs dose-dependently suppressed C-X-C chemokine receptor type 4 (CXCR4)- and C-C chemokine receptor type 5 (CCR5)-implicated chemotaxis in leukocytes.	Anthraquinones	21-34	chemokine (C-X-C motif) receptor 4	Mus musculus	71-102
22454693-4	2012	Catenarin and/or its anthraquinone analogs dose-dependently suppressed C-X-C chemokine receptor type 4 (CXCR4)- and C-C chemokine receptor type 5 (CCR5)-implicated chemotaxis in leukocytes.	Anthraquinones	21-34	chemokine (C-X-C motif) receptor 4	Mus musculus	104-109
22454693-4	2012	Catenarin and/or its anthraquinone analogs dose-dependently suppressed C-X-C chemokine receptor type 4 (CXCR4)- and C-C chemokine receptor type 5 (CCR5)-implicated chemotaxis in leukocytes.	Anthraquinones	21-34	chemokine (C-C motif) receptor 5	Mus musculus	116-145
22454693-4	2012	Catenarin and/or its anthraquinone analogs dose-dependently suppressed C-X-C chemokine receptor type 4 (CXCR4)- and C-C chemokine receptor type 5 (CCR5)-implicated chemotaxis in leukocytes.	Anthraquinones	21-34	chemokine (C-C motif) receptor 5	Mus musculus	147-151
22848767-6	2012	RESULTS: This study revealed that triterpenoid and steroid ligands were largely selective for sterol 14alpha-demethylase; anthraquinones, xanthones, and berberine alkaloids docked strongly to pteridine reductase 1 (TbPTR1); chromenes, pyrazole and pyridine alkaloids preferred docking to triose phosphate isomerase (TbTIM); and numerous indole alkaloids showed notable docking energies with UDP-galactose 4" epimerase (TbUDPGE).	Anthraquinones	122-136	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	94-120
22848767-6	2012	RESULTS: This study revealed that triterpenoid and steroid ligands were largely selective for sterol 14alpha-demethylase; anthraquinones, xanthones, and berberine alkaloids docked strongly to pteridine reductase 1 (TbPTR1); chromenes, pyrazole and pyridine alkaloids preferred docking to triose phosphate isomerase (TbTIM); and numerous indole alkaloids showed notable docking energies with UDP-galactose 4" epimerase (TbUDPGE).	Anthraquinones	122-136	triosephosphate isomerase 1	Homo sapiens	288-314
22848767-6	2012	RESULTS: This study revealed that triterpenoid and steroid ligands were largely selective for sterol 14alpha-demethylase; anthraquinones, xanthones, and berberine alkaloids docked strongly to pteridine reductase 1 (TbPTR1); chromenes, pyrazole and pyridine alkaloids preferred docking to triose phosphate isomerase (TbTIM); and numerous indole alkaloids showed notable docking energies with UDP-galactose 4" epimerase (TbUDPGE).	Anthraquinones	122-136	UDP-galactose-4-epimerase	Homo sapiens	391-417
22040556-9	2011	CONCLUSIONS: The decreased AQP8 expression in MC patients indicates that chronic use of laxatives containing anthraquinone may cause reduced water absorption.	Anthraquinones	109-122	aquaporin 8	Homo sapiens	27-31
21856437-0	2011	Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin.	Anthraquinones	85-99	tumor protein p53	Homo sapiens	19-22
21725878-11	2011	CONCLUSIONS: Rhu (anthraquinone purgatives) had apparent effect on inducing MC; its molecular mechanism is maybe to destroy intestinal mucosal barrier and advance proinflammatory factor TNF-alpha releasing, which leads to colonic epithelial cells apoptosis, and finally induce the change of MC due to the deposition of brown pigments, i.e. the macrophage phagocytized apoptotic body, on the colonic membrane.	Anthraquinones	18-31	tumor necrosis factor	Cavia porcellus	186-195
21602836-0	2011	CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives.	Anthraquinones	47-60	CF transmembrane conductance regulator	Rattus norvegicus	0-4
22007555-0	2011	[Experiment study of total anthraquinone in cassiae semen on lipid peroxidation and PPAR-gamma expression in liver tissues of rats with alcoholic fatty liver].	Anthraquinones	27-40	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	84-94
22007555-1	2011	OBJECTIVE: To investigate the effect of total anthraquinone in Cassiae Semen on lipid peroxidation and peroxisome proliferator activated receptors gamma (PPAR-gamma) expression in liver tissues of rats with alcoholic fatty liver.	Anthraquinones	46-59	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	103-152
22007555-7	2011	RESULT: Compared with the model group, total anthraquinone in Cassiae Semen could remarkably decrease the content of ALT, AST, TC, TG, MDA and increase the content of SOD in the serum of the experimental fatty liver induced by alcohol; remarkably decrease the content of TC, TG, FFA and increase the content of HL, LPL, SOD in the liver of the experimental fatty liver with induced by alcohol.	Anthraquinones	45-58	lipoprotein lipase	Rattus norvegicus	315-318
22007555-10	2011	Compared with the model group, total anthraquinone in Cassiae Semen could remarkably increase the expression of PPAR-gamma mRNA in the liver of the experimental fatty liver (P &lt; 0.01).	Anthraquinones	37-50	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	112-122
22007555-12	2011	the possible action mechanism of total anthraquinone in Cassiae Semen possess obvious effect of regulating the disorder of lipid metabolism, ameliorating hepatic function, as well as anti-lipidperoxidation, increasing the expression of PPAR-gamma in hepatic cells of rats.	Anthraquinones	39-52	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	236-246
21413718-2	2011	In this molecular triad excitation into the metal-ligand charge transfer bands results in the creation of a long-lived charge separated state with TTF acting as electron donor and anthraquinone as terminal acceptor.	Anthraquinones	180-193	ras homolog family member H	Homo sapiens	147-150
21425770-3	2011	In type A conjugates, the N-terminal group of the peptide chain is directly connected to the anthraquinone ring at C1 (Scheme 1), whereas types B and C conjugates possess an amide bond formed between the carboxyl group of heterocyclic molecule and the N-termini of the tuftsin chain.	Anthraquinones	93-106	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	115-127
21602836-1	2011	AIM: To clarify whether CFTR is a molecular target of intestinal fluid secretion caused by the anthraquinone compounds from laxative herbal plants.	Anthraquinones	95-108	CF transmembrane conductance regulator	Rattus norvegicus	24-28
21602836-5	2011	RESULTS: Anthraquinone compounds rhein, aloe-emodin and 1,8-dihydroxyanthraquinone (DHAN) stimulated I(-) influx through CFTR chloride channel in a dose-dependent manner in the presence of physiological concentration of cAMP.	Anthraquinones	9-22	CF transmembrane conductance regulator	Rattus norvegicus	121-125
21602836-9	2011	The anthraquinone compounds did not elevate cAMP level in cultured FRT cells and rat colonic mucosa, suggesting a direct effect on CFTR activity.	Anthraquinones	4-17	CF transmembrane conductance regulator	Rattus norvegicus	131-135
21602836-10	2011	CONCLUSION: Natural anthraquinone compounds in vegetable laxative drugs are CFTR potentiators that stimulated colonic chloride and fluid secretion.	Anthraquinones	20-33	CF transmembrane conductance regulator	Rattus norvegicus	76-80
20329777-4	2010	In the cases of anthracene and anthraquinone derivatives, the presence of syn and anti conformers was detected, and their interconversion barriers, due to the Ar-N rotation, were measured.	Anthraquinones	31-44	synemin	Homo sapiens	74-77
21112139-1	2011	Alizarin Red S (ARS), is a water-soluble, widely used anthraquinone dye synthesized by sulfonation of alizarin.	Anthraquinones	54-67	secreted LY6/PLAUR domain containing 1	Homo sapiens	16-19
21207957-1	2011	Evaluation and optimization of anthraquinone derivatives related to Reactive Blue 2 at P2X2 receptors yielded the first potent and selective P2X2 receptor antagonists.	Anthraquinones	31-44	purinergic receptor P2X 2	Rattus norvegicus	87-91
21207957-1	2011	Evaluation and optimization of anthraquinone derivatives related to Reactive Blue 2 at P2X2 receptors yielded the first potent and selective P2X2 receptor antagonists.	Anthraquinones	31-44	purinergic receptor P2X 2	Rattus norvegicus	141-145
21207957-7	2011	Several anthraquinone derivatives were found to act as positive modulators of ATP effects at P2X2 receptors, for example, sodium 1-amino-4-(3-phenoxyphenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate (51, PSB-10129, EC(50) 489 nM), which led to about a 3-fold increase in the ATP-elicited current.	Anthraquinones	8-21	purinergic receptor P2X 2	Rattus norvegicus	93-97
21171157-2	2011	Covalent attachment of IL-4 proceeded via anthraquinone photochemistry to introduce amine functionalities at the surface followed by coupling of IL-4 through a bifunctional amine-reactive linker.	Anthraquinones	42-55	interleukin 4	Homo sapiens	23-27
21461952-5	2011	A sulfonate at position 2 of the anthraquinone core created a strong interaction with the Lys174(EL2) side chain.	Anthraquinones	33-46	spectrin alpha, erythrocytic 1	Homo sapiens	97-100
20863847-2	2010	Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge.	Anthraquinones	30-43	epidermal growth factor receptor	Rattus norvegicus	112-117
20863847-2	2010	Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge.	Anthraquinones	30-43	epidermal growth factor like 1	Rattus norvegicus	213-216
21116777-2	2010	Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone compounds, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6"-O-acetyl)-alpha-rhamnosyl(1 2)-beta-glucoside and 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, as inhibitors on PRL-3.	Anthraquinones	89-102	protein tyrosine phosphatase 4A3	Homo sapiens	280-285
20146483-0	2010	Development of potent and selective inhibitors of ecto-5"-nucleotidase based on an anthraquinone scaffold.	Anthraquinones	83-96	5' nucleotidase, ecto	Rattus norvegicus	50-70
20146483-3	2010	In the present study, we synthesized and investigated a series of 55 anthraquinone derivatives as potential inhibitors of eN, 11 of which are novel compounds and another 11 of which had previously been described but have now been synthesized by an improved method.	Anthraquinones	69-82	5' nucleotidase, ecto	Rattus norvegicus	122-124
20545205-1	2010	OBJECTIVE: To research the effect of anthraquinone extracted from rubiqmnone on growth inhibition, introduction apoptosis and expression of relative gene of bcl-2 of hepatocarcinoma cell SMMC 7721, and provide the effective target of gene therapy.	Anthraquinones	37-50	BCL2 apoptosis regulator	Homo sapiens	157-162
20545205-4	2010	The effect of anthraquinone on bcl-2mRNA expression was analyzed by RT-PCR.	Anthraquinones	14-27	BCL2 apoptosis regulator	Homo sapiens	31-36
20545205-9	2010	The apoptosis fuction of anthraquinone introdution hepatocarcinoma cell was further certified by Annexin V-FITC/PI.	Anthraquinones	25-38	annexin A5	Homo sapiens	97-106
20545205-10	2010	Anthraquinone could decrease the expression of bcl-2mRNA by RT-PCR.	Anthraquinones	0-13	BCL2 apoptosis regulator	Homo sapiens	47-52
20195820-0	2010	Anthraquinones from the roots of Knoxia valerianoides inhibit the formation of advanced glycation end products and rat lens aldose reductase in vitro.	Anthraquinones	0-14	aldo-keto reductase family 1 member B1	Rattus norvegicus	124-140
20128807-0	2010	SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway.	Anthraquinones	18-31	AKT serine/threonine kinase 1	Homo sapiens	113-116
20353011-0	2009	[Regulating effects of aquaporin 4 expression in LoVo cells by serum containing total anthraquinone in rheum].	Anthraquinones	86-99	aquaporin 4	Homo sapiens	23-34
20353011-1	2009	OBJECTIVE: To investigate the regulating effects of serum containing total anthraquinone in rheum on the expression of AQP4 in cultured LoVo cells in vitro.	Anthraquinones	75-88	aquaporin 4	Homo sapiens	119-123
20353011-4	2009	LoVo cells cultured in vitro were treated with different concentrations of total anthraquinone in rheum for 24 h. The expression levels of protein and mRNA of AQP4 IN LoVo cells were decided by Western blot and semiquantive RT-PCR.	Anthraquinones	81-94	aquaporin 4	Homo sapiens	159-163
20353011-5	2009	RESULT: Western blot and semiquantive RT-PCR showed that serum containing total anthraquinone in rheum prepared from rats treated with 4.5 g x kg(-1) x d(-1) of total anthraquinone in rheum could inhibit the expression of mRNA and protein levels of AQP 4 in LoVo cells (P&lt;0.01).	Anthraquinones	80-93	aquaporin 4	Rattus norvegicus	249-254
20353011-5	2009	RESULT: Western blot and semiquantive RT-PCR showed that serum containing total anthraquinone in rheum prepared from rats treated with 4.5 g x kg(-1) x d(-1) of total anthraquinone in rheum could inhibit the expression of mRNA and protein levels of AQP 4 in LoVo cells (P&lt;0.01).	Anthraquinones	167-180	aquaporin 4	Rattus norvegicus	249-254
20353011-6	2009	CONCLUSION: Serum containing total anthraquinone in rheum can inhibit both the transcription and translation of AQP4 gene, indicating that the regulation mechanism of rhubarb on the expression of AQP4 can be related to the cathartic effect of rhubarb.	Anthraquinones	35-48	aquaporin 4	Homo sapiens	112-116
19269596-0	2009	Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	Anthraquinones	36-50	aryl hydrocarbon receptor	Homo sapiens	101-126
20353011-6	2009	CONCLUSION: Serum containing total anthraquinone in rheum can inhibit both the transcription and translation of AQP4 gene, indicating that the regulation mechanism of rhubarb on the expression of AQP4 can be related to the cathartic effect of rhubarb.	Anthraquinones	35-48	aquaporin 4	Homo sapiens	196-200
19402184-6	2009	Separation and quantitation of anthraquinones was accomplished using a reversed-phase C18 column with the mobile phase of methanol-water-phosphoric acid (600:400:1), and the detection wavelength of 254 nm.	Anthraquinones	31-45	Bardet-Biedl syndrome 9	Homo sapiens	86-89
19269596-3	2009	We investigated the effects of 18 anthraquinones and 7 of their structurally related compounds on transformation of the AhR estimated by its DNA-binding activity in the cell-free system.	Anthraquinones	34-48	aryl hydrocarbon receptor	Homo sapiens	120-123
18044952-1	2007	Anthraquinone-bridged mononuclear and dinuclear complexes, [PtCl(AQ-amide-tpy)](PF6) (1), [Pt2Cl2(AQ-amide-tpy2)](PF6)2 (2), and [Pt2Cl2(AQ-eth-tpy2)](PF6)2 (3), were synthesized and their photochemical properties were investigated.	Anthraquinones	0-13	sperm associated antigen 17	Homo sapiens	80-83
19152226-2	2009	Here, we report that the natural anthraquinones, emodin, emodic acid, chrysazin, physcion, and rhein differentially inhibit several members of this enzyme family, the gelatinases MMP-2 and -9, and the collagenase MMP-13.	Anthraquinones	33-47	matrix metallopeptidase 2	Homo sapiens	179-191
19152226-2	2009	Here, we report that the natural anthraquinones, emodin, emodic acid, chrysazin, physcion, and rhein differentially inhibit several members of this enzyme family, the gelatinases MMP-2 and -9, and the collagenase MMP-13.	Anthraquinones	33-47	matrix metallopeptidase 13	Homo sapiens	213-219
18841780-0	2008	[Effect of total anthraquinone in rheum on aquaporin 2 expression in rat distal colon].	Anthraquinones	17-30	aquaporin 2	Rattus norvegicus	43-54
18841780-1	2008	OBJECTIVE: To investigate effect of total anthraquinone in rheum on aquaporin 2 expression in rat distal colon.	Anthraquinones	42-55	aquaporin 2	Rattus norvegicus	68-79
18841780-9	2008	CONCLUSION: Total anthraquinone in rheum can reduce the transcription and translation of AQP2 in rats" distal colon, increase fecal water content, which probably is one of the mechanisms of diarrhea caused by total anthraquinone in rheum.	Anthraquinones	18-31	aquaporin 2	Rattus norvegicus	89-93
18841780-9	2008	CONCLUSION: Total anthraquinone in rheum can reduce the transcription and translation of AQP2 in rats" distal colon, increase fecal water content, which probably is one of the mechanisms of diarrhea caused by total anthraquinone in rheum.	Anthraquinones	215-228	aquaporin 2	Rattus norvegicus	89-93
17949858-7	2008	The cytotoxicity of the anthraquinone and naphthoquinone derivatives on P-gp-underexpressing HCT 116 cells and P-gp-overexpressing Hep G2 cells was examined by MTT assay.	Anthraquinones	24-37	phosphoglycolate phosphatase	Homo sapiens	72-76
17869316-4	2008	On the other hand, some flavones such as apigenin, flavonols such as quercetin, and anthraquinones such as emodin, showed notable inhibitory effects on the in vitro activation of AhR induced by the dioxin [2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)].	Anthraquinones	84-98	aryl hydrocarbon receptor	Homo sapiens	179-182
19065897-0	2008	[Regulatory effect of anthraquinone derivatives from rhubarb on aquaporin 4 expression in colon of rats and in LoVo cell line].	Anthraquinones	22-35	aquaporin 4	Rattus norvegicus	64-75
19065897-1	2008	OBJECTIVE: To investigate the cathartic effect of total anthraquinone (AQ) from rhubarb on SD rats and its regulatory effect on aquaporin 4 (AQP4) expression in rat colon and in vitro cultured LoVo cell line.	Anthraquinones	56-69	aquaporin 4	Rattus norvegicus	128-139
19065897-1	2008	OBJECTIVE: To investigate the cathartic effect of total anthraquinone (AQ) from rhubarb on SD rats and its regulatory effect on aquaporin 4 (AQP4) expression in rat colon and in vitro cultured LoVo cell line.	Anthraquinones	56-69	aquaporin 4	Rattus norvegicus	141-145
19065897-1	2008	OBJECTIVE: To investigate the cathartic effect of total anthraquinone (AQ) from rhubarb on SD rats and its regulatory effect on aquaporin 4 (AQP4) expression in rat colon and in vitro cultured LoVo cell line.	Anthraquinones	71-73	aquaporin 4	Rattus norvegicus	128-139
19065897-1	2008	OBJECTIVE: To investigate the cathartic effect of total anthraquinone (AQ) from rhubarb on SD rats and its regulatory effect on aquaporin 4 (AQP4) expression in rat colon and in vitro cultured LoVo cell line.	Anthraquinones	71-73	aquaporin 4	Rattus norvegicus	141-145
19065897-8	2008	CONCLUSION: At the same time of playing cathartic action, total AQ of rhubarb can effectively down-regulate the expression of AQP4 in rat"s proximal colon; rhein/emodin can suppress the AQP4 expression in LoVo cells in vitro.	Anthraquinones	64-66	aquaporin 4	Rattus norvegicus	126-130
18389468-7	2008	The three anthraquinones slightly activated tyrosinase with effects in the range 7-31%.	Anthraquinones	10-24	tyrosinase	Mus musculus	44-54
18025460-2	2007	Here we describe the oxidation of a cell-cycle regulatory protein, p53, from a distance through DNA-mediated CT. A consensus p53 binding site as well as three DNA promoters regulated by p53 were synthesized containing a tethered DNA photooxidant, anthraquinone.	Anthraquinones	247-260	tumor protein p53	Homo sapiens	67-70
17978503-0	2007	Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.	Anthraquinones	0-14	aldo-keto reductase family 1 member B1	Rattus norvegicus	95-111
17760420-7	2007	Collectively, the results from Western blotting, EMSAs, and DNA footprinting reactions lead to the conclusion that AQ-initiated DNA CT is responsible for DNA-H3 cross-linking in one specific region of these NCPs.	Anthraquinones	115-117	dynein axonemal heavy chain 3	Homo sapiens	154-160
17249732-1	2007	Derivatives of 9,10-bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene (ex-TTF) have been synthesized by a new synthetic methodology, viz., direct phosphite-mediated cross-couplings of anthraquinone with 1,3-dithiole-2-thione derivatives.	Anthraquinones	184-197	ras homolog family member H	Homo sapiens	74-77
17531219-1	2007	We demonstrate the capacity of an herbal anthraquinone aloe emodin to reduce the cytotoxicity of the proinflammatory cytokine tumor necrosis factor (TNF) towards L929 mouse fibrosarcoma and U251 human glioma cell lines.	Anthraquinones	41-54	tumor necrosis factor	Mus musculus	126-147
17531219-1	2007	We demonstrate the capacity of an herbal anthraquinone aloe emodin to reduce the cytotoxicity of the proinflammatory cytokine tumor necrosis factor (TNF) towards L929 mouse fibrosarcoma and U251 human glioma cell lines.	Anthraquinones	41-54	tumor necrosis factor	Mus musculus	149-152
16730806-8	2007	Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner.	Anthraquinones	11-24	angiotensin converting enzyme 2	Homo sapiens	114-118
16624401-10	2007	On the anthraquinone-coupled Fn coatings, cell adhesion and spreading of human keratinocytes was significantly enhanced.	Anthraquinones	7-20	fibronectin 1	Homo sapiens	29-31
17310736-4	2007	Disperse Red 92, which has also been detected in the treated effluent from a sewage plant receiving the wastewater, is an anthraquinone disperse dye showing weak AhR binding affinity in the assay.	Anthraquinones	122-135	aryl hydrocarbon receptor	Homo sapiens	162-165
17056031-0	2006	Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation.	Anthraquinones	0-13	mitogen-activated protein kinase 3	Mus musculus	93-132
16864436-2	2006	Three anthraquinones (5-7) showed moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.	Anthraquinones	6-20	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	69-100
16864436-2	2006	Three anthraquinones (5-7) showed moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.	Anthraquinones	6-20	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	102-108
15525637-0	2005	Anthraquinones inhibit tau aggregation and dissolve Alzheimer"s paired helical filaments in vitro and in cells.	Anthraquinones	0-14	microtubule associated protein tau	Homo sapiens	23-26
16088894-5	2005	Among the pro-inflammatory signals, the ability of the two anthraquinones to interfere with the production of superoxide anion (O(2) (-)), which was assumed as a marker of reactive oxygen species (ROS), was evaluated in an in vitro cell model by testing phagocytes, such as human neutrophils, challenged by the chemotactic agent N-formylmethionyl-leucyl-phenylalanine (FMLP).	Anthraquinones	59-73	formyl peptide receptor 1	Homo sapiens	369-373
16521213-10	2006	When only the data from the 11 patients treated with anthraquinone drug, mitoxantrone, were analyzed, however, the number of patients who showed poor response to treatment was significantly higher among the p53-positive patients (P=0.012), irrespective of the survival outcome.	Anthraquinones	53-66	tumor protein p53	Homo sapiens	207-210
16521213-12	2006	Similarly, immunostaining to evaluate p53 protein may be useful to predict the response in patients treated with an anthraquinone drug.	Anthraquinones	116-129	tumor protein p53	Homo sapiens	38-41
16215684-0	2005	Mechanisms of induction of apoptosis by anthraquinone anticancer drugs aclarubicin and mitoxantrone in comparison with doxorubicin: relation to drug cytotoxicity and caspase-3 activation.	Anthraquinones	40-53	caspase 3	Mus musculus	166-175
16382174-4	2005	Steady-state kinetic studies were done with several anthraquinone-containing compounds, including 13-deoxydoxorubicin and daunorubicinol, which lack the C13 carbonyl, thus unmasking the anthraquinone for study.	Anthraquinones	186-199	homeobox C13	Homo sapiens	153-156
15905960-6	2005	Taken together, these data indicate that herbal anthraquinone AE can downregulate the anticancer activity of cisplatin by blocking the activation of ERK in tumor cells.	Anthraquinones	48-61	mitogen-activated protein kinase 1	Mus musculus	149-152
15989761-2	2005	This study was to assess the effects of anthraquinone derivatives, rhein on synaptic transmission in the rat hippocampal CA1 pyramidal cell layer by intracellular recording.	Anthraquinones	40-53	carbonic anhydrase 1	Rattus norvegicus	121-124
12878034-1	2003	The lactoperoxidase (LPO) catalysed oxidation of mitoxantrone, an anthraquinone type anti-cancer drug, was studied spectrophotometrically under turnover and single turnover conditions with a stopped flow apparatus.	Anthraquinones	66-79	lactoperoxidase	Homo sapiens	4-19
16379572-4	2005	It was revealed that anthraquinone showed significantly increased elaboration of procollagen type I C-terminal peptide and glycosaminoglycans and reduced expression of the collagenase matrix metalloproteinase-1 dose-dependently in human dermal fibroblasts.	Anthraquinones	21-34	matrix metallopeptidase 1	Homo sapiens	184-210
15501482-11	2004	Each of these anthraquinones demonstrated significant antigenotoxicity against Trp-P-1 in the Comet assay.	Anthraquinones	14-28	polycystin 1, transient receptor potential channel interacting	Homo sapiens	79-86
15196053-1	2004	In the present study, the binding of two non-substrate anthraquinone dyes VBAR (Vilmafix Blue A-R) and CB3GA (Cibacron Blue 3GA) to maize (Zea mays) GST I was investigated.	Anthraquinones	55-68	glutathione S-transferase 1	Zea mays	149-154
14646185-4	2003	Among them, flavones, flavonols, anthraquinones, piperine, coumestrol, brevifolincarboxylic acid, and resveratrol showed marked inhibitory effects on AhR-based bioassay activation by TCDD, and their effects were dose dependent.	Anthraquinones	33-47	aryl hydrocarbon receptor	Homo sapiens	150-153
15509168-8	2004	Direct observation of anthraquinone fluorescence of targeted drug in PC3 cells showed initial cytosolic localization, independent of AR expression, with predominant nuclear localization after sufficient time for release of drug from the targeting moiety.	Anthraquinones	22-35	chromobox 8	Homo sapiens	69-72
15120460-0	2004	Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.	Anthraquinones	71-85	monoamine oxidase A	Rattus norvegicus	14-19
12852760-0	2003	Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone.	Anthraquinones	123-136	telomerase reverse transcriptase	Homo sapiens	20-52
12878034-1	2003	The lactoperoxidase (LPO) catalysed oxidation of mitoxantrone, an anthraquinone type anti-cancer drug, was studied spectrophotometrically under turnover and single turnover conditions with a stopped flow apparatus.	Anthraquinones	66-79	lactoperoxidase	Homo sapiens	21-24
12808242-7	2003	In addition, an anthraquinone constituent, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, was found to show inhibitory effects on the release of beta-hexosaminidase in RBL-2H3 cells.	Anthraquinones	16-29	O-GlcNAcase	Rattus norvegicus	144-163
12808242-7	2003	In addition, an anthraquinone constituent, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, was found to show inhibitory effects on the release of beta-hexosaminidase in RBL-2H3 cells.	Anthraquinones	16-29	RB transcriptional corepressor like 2	Rattus norvegicus	167-172
12688675-0	2003	Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase.	Anthraquinones	41-54	cytochrome p450 oxidoreductase	Homo sapiens	135-166