PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23876369-1	2013	Four paclitaxel derivatives were afforded by preparative HPLC separation of two pairs of diastereoisomers, which were obtained by catalytic hydrogenation and epoxidation of the C-13 side-chain double bond of cephalomannine, a naturally occurring paclitaxel analog.	cephalomannine	208-222	homeobox C13	Homo sapiens	177-181
15110841-5	2004	The other compounds used, one derivative, cephalomannine, and five intermediates synthesized chemically inhibited only the pol.alpha activity in vitro.	cephalomannine	42-56	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	123-132
12778728-4	2003	Cephalomannine caused the induction of a new fluorescence peak at 651 nm only above 1 muM.	cephalomannine	0-14	latexin	Homo sapiens	86-89
33589597-8	2021	Most importantly, the small-molecule cephalomannine was found by a luciferase-based sensitive high-throughput screen (HTS) to inhibit UBE2S expression and significantly attenuate HCC progression in vitro and in vivo, which may represent a promising strategy for HCC therapy.	cephalomannine	37-51	ubiquitin conjugating enzyme E2 S	Homo sapiens	134-139
33990544-0	2021	Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1alpha interaction in lung cancer.	cephalomannine	0-14	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	81-86
33990544-0	2021	Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1alpha interaction in lung cancer.	cephalomannine	0-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
33990544-7	2021	Cephalomannine (CPM), a natural compound, exerted inhibitory effects in hypoxic LC cells via the inhibition of APEX1/HIF-1alpha interaction in vitro and in vivo.	cephalomannine	0-14	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	111-116
33990544-7	2021	Cephalomannine (CPM), a natural compound, exerted inhibitory effects in hypoxic LC cells via the inhibition of APEX1/HIF-1alpha interaction in vitro and in vivo.	cephalomannine	0-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
33990544-7	2021	Cephalomannine (CPM), a natural compound, exerted inhibitory effects in hypoxic LC cells via the inhibition of APEX1/HIF-1alpha interaction in vitro and in vivo.	cephalomannine	16-19	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	111-116
33990544-7	2021	Cephalomannine (CPM), a natural compound, exerted inhibitory effects in hypoxic LC cells via the inhibition of APEX1/HIF-1alpha interaction in vitro and in vivo.	cephalomannine	16-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
9150481-5	1997	We found that taxanes that are active in promoting microtubule assembly, including paclitaxel, 10-deactyl-taxol and cephalomannine increased the survival of polycystic cpk/cpk mice significantly longer than control animals.	cephalomannine	116-130	cystin 1	Mus musculus	168-171
19128972-1	2009	Three fluorescent probes 3a,3b, and 4 have been synthesized through conjugation of fluorescein and difluorescein groups to the 7-OH of C-2 modified paclitaxel and cephalomannine derivatives with very high affinity to microtubules.	cephalomannine	163-177	complement C2	Homo sapiens	135-138
19795923-6	2009	In comparison with cephalomannine, the catalytic efficiency of CYP2C8 for 7-epi-cephalomannine was about five-fold higher due to the decreased K(m).	cephalomannine	19-33	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	63-69
18039807-6	2008	Compared with paclitaxel, the major hydroxylation site transferred from C6alpha to C4"", and the main metabolizing P450 changed from CYP2C8 to CYP3A4 for cephalomannine.	cephalomannine	154-168	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	133-139
18039807-6	2008	Compared with paclitaxel, the major hydroxylation site transferred from C6alpha to C4"", and the main metabolizing P450 changed from CYP2C8 to CYP3A4 for cephalomannine.	cephalomannine	154-168	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	143-149
18039807-9	2008	Kinetic studies showed that CYP3A4 catalyzed cephalomannine more efficiently than paclitaxel due to an increased V(m).	cephalomannine	45-59	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	28-34