PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26094731-3	2015	Curcumin and calphostin C suppressed the activity and phosphorylation of recombinant UGT1A3 expressed in Sf9 cells.	calphostin C	13-25	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	85-91
26094731-8	2015	Furthermore, the UGT1A3 activity of wild-type and S43G-mutant was down-regulated by calphostin C, whereas the calphostin C inhibitory effect was much weaker on the S43G-mutant than the wild-type.	calphostin C	84-96	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	17-23
26065917-6	2015	Phosphorylated Erk1/2 mitogen-activated protein kinase, PKCtheta and PKCbeta stimulated interactions between p47phox and p22phox; these interactions were prevented by MEK and PKC inhibitors (PD98059 and calphostin C, respectively).	calphostin C	203-215	mitogen-activated protein kinase 3	Homo sapiens	15-21
26065917-6	2015	Phosphorylated Erk1/2 mitogen-activated protein kinase, PKCtheta and PKCbeta stimulated interactions between p47phox and p22phox; these interactions were prevented by MEK and PKC inhibitors (PD98059 and calphostin C, respectively).	calphostin C	203-215	protein kinase C beta	Homo sapiens	69-76
26065917-6	2015	Phosphorylated Erk1/2 mitogen-activated protein kinase, PKCtheta and PKCbeta stimulated interactions between p47phox and p22phox; these interactions were prevented by MEK and PKC inhibitors (PD98059 and calphostin C, respectively).	calphostin C	203-215	neutrophil cytosolic factor 1	Homo sapiens	109-116
26065917-6	2015	Phosphorylated Erk1/2 mitogen-activated protein kinase, PKCtheta and PKCbeta stimulated interactions between p47phox and p22phox; these interactions were prevented by MEK and PKC inhibitors (PD98059 and calphostin C, respectively).	calphostin C	203-215	cytochrome b-245 alpha chain	Homo sapiens	121-128
26065917-6	2015	Phosphorylated Erk1/2 mitogen-activated protein kinase, PKCtheta and PKCbeta stimulated interactions between p47phox and p22phox; these interactions were prevented by MEK and PKC inhibitors (PD98059 and calphostin C, respectively).	calphostin C	203-215	mitogen-activated protein kinase kinase 7	Homo sapiens	167-170
26065917-6	2015	Phosphorylated Erk1/2 mitogen-activated protein kinase, PKCtheta and PKCbeta stimulated interactions between p47phox and p22phox; these interactions were prevented by MEK and PKC inhibitors (PD98059 and calphostin C, respectively).	calphostin C	203-215	protein kinase C beta	Homo sapiens	56-59
25688212-7	2015	Macropinocytosis in response to M-CSF and PMA was inhibited by the Ras inhibitor farnesyl thiosalicylate (FTS), by the PKC inhibitor Calphostin C and by the broad specificity inhibitor rottlerin.	calphostin C	133-145	colony stimulating factor 1	Homo sapiens	32-37
25792644-9	2015	Modulation of thyroid cells in culture with 12-O-tetradecanoylphorbol-13-acetate (TPA)+-calphostin C supported a direct role of pKC in these altered properties.	calphostin C	88-100	protein kinase C, gamma	Rattus norvegicus	128-131
25678708-8	2015	Protein kinase C antagonists calphostin C and chelerythrine chloride as well as dialysis of cells with 1,2bis(2aminophenoxy)ethaneN,N,N",N"-tetraacetic acid abolished the U-II-induced responses, whereas PKCalpha inhibition or PKA blockade had no effect.	calphostin C	29-41	urotensin 2	Rattus norvegicus	171-175
24466329-4	2014	Pretreatment with the protein synthesis inhibitor cycloheximide or the protein kinase C inhibitor calphostin C prior to the addition of TNF completely abrogated the TNF-induced increment in peak bradykinin response.	calphostin C	98-110	tumor necrosis factor	Homo sapiens	165-168
24522860-7	2014	Furthermore, M3 mAChR-mediated NF-kappaB activation and IL-8 expression were simultaneously attenuated by the PKC inhibitor calphostin C, whereas PMA, a PKC activator, mimicked the effects of carbachol, inducing IL-8 expression.	calphostin C	124-136	nuclear factor kappa B subunit 1	Homo sapiens	31-40
24522860-7	2014	Furthermore, M3 mAChR-mediated NF-kappaB activation and IL-8 expression were simultaneously attenuated by the PKC inhibitor calphostin C, whereas PMA, a PKC activator, mimicked the effects of carbachol, inducing IL-8 expression.	calphostin C	124-136	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
24522860-7	2014	Furthermore, M3 mAChR-mediated NF-kappaB activation and IL-8 expression were simultaneously attenuated by the PKC inhibitor calphostin C, whereas PMA, a PKC activator, mimicked the effects of carbachol, inducing IL-8 expression.	calphostin C	124-136	proline rich transmembrane protein 2	Homo sapiens	110-113
24522860-7	2014	Furthermore, M3 mAChR-mediated NF-kappaB activation and IL-8 expression were simultaneously attenuated by the PKC inhibitor calphostin C, whereas PMA, a PKC activator, mimicked the effects of carbachol, inducing IL-8 expression.	calphostin C	124-136	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
24466329-4	2014	Pretreatment with the protein synthesis inhibitor cycloheximide or the protein kinase C inhibitor calphostin C prior to the addition of TNF completely abrogated the TNF-induced increment in peak bradykinin response.	calphostin C	98-110	kininogen 1	Homo sapiens	195-205
24060489-6	2013	Two previously reported beta-catenin/TCF antagonists (calphostin C, xanthothricin) and XAV939 (tankyrase antagonist) inhibited Wnt-activated genes in a dose-dependent fashion.	calphostin C	54-66	catenin beta 1	Rattus norvegicus	24-36
24060489-6	2013	Two previously reported beta-catenin/TCF antagonists (calphostin C, xanthothricin) and XAV939 (tankyrase antagonist) inhibited Wnt-activated genes in a dose-dependent fashion.	calphostin C	54-66	Wnt family member 2	Rattus norvegicus	127-130
23826669-10	2014	Inhibition of protein kinase C (PKC) activation with calphostin C and chelerythrine partially suppressed palmitate-stimulated IL-8 expression, but it had no effect on palmitate-induced NF-kappaB activation.	calphostin C	53-65	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23156739-7	2012	AGE-HSA up-regulated the expression of FN mRAN and protein in dose- and time-dependently (P < 0.01); PKC activator phorbol 12-myristate 13-acetate (PMA) induced FN expression, respectively depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and AGE-HSA-induced expression of the FN (P < 0.05).	calphostin C	213-225	fibronectin 1	Homo sapiens	39-41
23666553-4	2013	Calphostin C, (the inhibitor of PKC alpha) and phorbol-12-myristate 13-acetate-PMA (the agonist of PKC alpha) were used to treat the prostate carcinoma cells, and the cell proliferation and invasion abilities were measured by CCK-8 and wound-healing assays.	calphostin C	0-12	protein kinase C alpha	Homo sapiens	32-41
23526078-8	2013	Proliferation of ACHN cells was concentration dependent in the presence of PMA and calphostin C. Netrin-1 and UNC5B expressions were upregulated in cells treated with PMA while calphostin C reversed this upregulation.	calphostin C	83-95	netrin 1	Homo sapiens	97-105
23526078-8	2013	Proliferation of ACHN cells was concentration dependent in the presence of PMA and calphostin C. Netrin-1 and UNC5B expressions were upregulated in cells treated with PMA while calphostin C reversed this upregulation.	calphostin C	83-95	unc-5 netrin receptor B	Homo sapiens	110-115
23413252-4	2013	PKC inhibition with calphostin C and Go-6850 (10(-5) M) caused a significant decrease (~25%) in slow-rate (but not fast-rate) phasic activity (monitored by frequency and amplitude of contractions) of the RSM.	calphostin C	20-32	protein kinase C alpha	Homo sapiens	0-3
23261315-7	2013	Pretreatment of cells with the classical and novel PKC antagonists GF109203X and calphostin C completely abolished curcumin-induced IBa inhibition, whereas the classical PKC antagonist Go6976 or inhibition of PKA activity elicited no such effects.	calphostin C	81-93	protein kinase C, epsilon	Rattus norvegicus	51-54
23085996-7	2013	The inhibitory effect of calphostin C, a specific inhibitor of protein kinase C (PKC), on the Gardos channel was eliminated after BDA-410 treatment, which suggests that calpain-1 inhibition affects the PKC-dependent fraction of the Gardos channel.	calphostin C	25-37	calpain 1	Mus musculus	169-178
21986923-4	2012	RESULTS: Rosiglitazone and calphostin C (a protein kinase C inhibitor) inhibited VEGF secretion by PBMCs by 63.7 and 62.3%, respectively.	calphostin C	27-39	vascular endothelial growth factor A	Homo sapiens	81-85
21871968-6	2011	It was hypothesized that these unique responses were transduced by activation of different protein kinase C isotypes, supported by the observation that LNO(2)-mediated inhibition of Ca(2+) influx was blocked by the non-selective PKC inhibitors chelerythine chloride and calphostin C, but not by the calcium dependent "classic" PKC inhibitor Go6976.	calphostin C	270-282	protein kinase C zeta	Homo sapiens	229-232
22615852-8	2012	In retinal endothelial cells, the high glucose-induced IL-1beta overexpression was prevented by calphostin C, a protein kinase C inhibitor.	calphostin C	96-108	interleukin 1 beta	Rattus norvegicus	55-63
21317540-4	2011	When UGT1A-expressing HEK293 cells and LS180 cells were treated with curcumin or calphostin C, the exogenous and endogenous UGT1A protein levels in homogenates prepared with Tris-buffered saline were significantly decreased.	calphostin C	81-93	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	5-10
21317540-6	2011	When the curcumin- or calphostin C-treated cells were lysed with buffer containing a detergent, the UGT protein levels did not decrease.	calphostin C	22-34	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	100-103
21317540-7	2011	We found that curcumin or calphostin C treatment facilitated the degradation of UGT protein after the cells were collected in the absence of a detergent.	calphostin C	26-38	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	80-83
21195749-10	2011	In hippocampus, we found both PKA and PKC inhibition, using Rp-8-Br-cAMP and Calphostin C, respectively, blocked GABA(A)Ralpha1 internalization, whereas inhibition of MAPK (U0126) and PI3K (LY294002) did not prevent rapid internalization.	calphostin C	77-89	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	Mus musculus	113-127
20880454-8	2010	The effect of isoflurane on upregulating VEGF expression was blocked by PKC inhibitor calphostin C (P < 0.01), but calphostin C did not alter VEGF expression (P > 0.05).	calphostin C	86-98	vascular endothelial growth factor A	Rattus norvegicus	41-45
21177779-10	2011	Downregulation of protein kinase C (PKC) using phorbol 12-myristate 13-acetate, or PKC inhibition with calphostin C, markedly reduced flow-stimulated ET-1 mRNA levels.	calphostin C	103-115	endothelin 1	Rattus norvegicus	150-154
21068657-11	2010	The PKC inhibitor calphostin C abolished the cardioprotective effects of LPC16.	calphostin C	18-30	protein kinase C, alpha	Rattus norvegicus	4-7
20599609-7	2010	The classical and novel protein kinase C (PKC) antagonist calphostin C, as well as phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, abolished NMU responses, whereas the classical PKC antagonist Go6976 had no such effects.	calphostin C	58-70	protein kinase C, epsilon	Mus musculus	42-45
20599609-7	2010	The classical and novel protein kinase C (PKC) antagonist calphostin C, as well as phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, abolished NMU responses, whereas the classical PKC antagonist Go6976 had no such effects.	calphostin C	58-70	neuromedin U	Mus musculus	150-153
20880454-8	2010	The effect of isoflurane on upregulating VEGF expression was blocked by PKC inhibitor calphostin C (P < 0.01), but calphostin C did not alter VEGF expression (P > 0.05).	calphostin C	86-98	protein kinase C, gamma	Rattus norvegicus	72-75
20417648-6	2010	Pan-PKC inhibitors, calphostin C and chelerythrine, abrogated these responses.	calphostin C	20-32	protein kinase C zeta	Homo sapiens	4-7
19965895-5	2010	Calphostin C, an inhibitor of conventional and novel PKC isozymes, and the relatively selective PKCdelta inhibitor rottlerin decreased TN-stimulated glioma invasiveness in a concentration- and time-dependent manner.	calphostin C	0-12	tenascin C	Homo sapiens	135-137
20211725-6	2010	Decreased motility and phosphoMARCKS levels in OA-treated cells were observed with a PKC inhibitor (calphostin C), thus indicating that PKC actively phosphorylates MARCKS in F1 cells but that this reaction is efficiently reversed by protein phosphatases.	calphostin C	100-112	protein kinase C, alpha	Mus musculus	85-88
20211725-6	2010	Decreased motility and phosphoMARCKS levels in OA-treated cells were observed with a PKC inhibitor (calphostin C), thus indicating that PKC actively phosphorylates MARCKS in F1 cells but that this reaction is efficiently reversed by protein phosphatases.	calphostin C	100-112	protein kinase C, alpha	Mus musculus	136-139
20211725-6	2010	Decreased motility and phosphoMARCKS levels in OA-treated cells were observed with a PKC inhibitor (calphostin C), thus indicating that PKC actively phosphorylates MARCKS in F1 cells but that this reaction is efficiently reversed by protein phosphatases.	calphostin C	100-112	myristoylated alanine rich protein kinase C substrate	Mus musculus	30-36
20339915-6	2010	Calphostin C, an inhibitor of PKC, blocked the up-regulation of c-gelsolin induced by A23187, while inhibitors of mitogen-activated protein kinases had no effect on c-gelsolin expression.	calphostin C	0-12	gelsolin	Homo sapiens	66-74
19903468-8	2010	We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition.	calphostin C	69-81	plasminogen activator, urokinase	Homo sapiens	20-23
19903468-8	2010	We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition.	calphostin C	69-81	proline rich transmembrane protein 2	Homo sapiens	53-56
20032465-7	2010	Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells.	calphostin C	123-135	protein kinase C, gamma	Rattus norvegicus	32-48
20032465-7	2010	Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells.	calphostin C	123-135	protein kinase C, gamma	Rattus norvegicus	50-53
20032465-7	2010	Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells.	calphostin C	123-135	protein kinase C, gamma	Rattus norvegicus	60-63
20032465-7	2010	Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells.	calphostin C	123-135	sphingosine-1-phosphate receptor 1	Rattus norvegicus	188-194
20157239-7	2010	Pretreatment of cells with Calphostin C, an inhibitor of PKC, blocked the upregulation of cgelsolin induced by H(2)O(2), while specific inhibitors of MAPKs had no effect on c-gelsolin expression, suggesting that MAPKs may not be involved in H(2)O(2)mediated upregulation of cgelsolin.	calphostin C	27-39	proline rich transmembrane protein 2	Homo sapiens	57-60
19800889-6	2010	In addition, it was found that PTTH-stimulated ecdysteroidogenesis was greatly attenuated by treatment with PKC inhibitors (either calphostin C or chelerythrine C).	calphostin C	131-143	prothoracicotropic hormone	Bombyx mori	31-35
20038746-7	2010	Pretreatment with calphostin C (broad-spectrum PKC inhibitor) or rottlerin (PKCdelta inhibitor) reduced NAD(P)H oxidase activity by approximately 80% in both groups; however, PKCalpha/beta or PKCbeta inhibition did not alter NAD(P)H oxidase activity in either group.	calphostin C	18-30	protein kinase C, alpha	Rattus norvegicus	47-50
20038746-7	2010	Pretreatment with calphostin C (broad-spectrum PKC inhibitor) or rottlerin (PKCdelta inhibitor) reduced NAD(P)H oxidase activity by approximately 80% in both groups; however, PKCalpha/beta or PKCbeta inhibition did not alter NAD(P)H oxidase activity in either group.	calphostin C	18-30	protein kinase C, beta	Rattus norvegicus	192-199
19699794-8	2010	In addition, H(2)O(2)-induced cell death was prevented by PD98059, SB203580, and calphostin C, which are MEK, p38 and PKC inhibitors, respectively.	calphostin C	81-93	mitogen-activated protein kinase kinase 7	Homo sapiens	105-108
19699794-8	2010	In addition, H(2)O(2)-induced cell death was prevented by PD98059, SB203580, and calphostin C, which are MEK, p38 and PKC inhibitors, respectively.	calphostin C	81-93	mitogen-activated protein kinase 1	Homo sapiens	110-113
19672103-7	2010	Moreover, calphostin C (a PKC inhibitor) inhibited TGF-beta(1)-induced alpha-SMA expression, whereas phorbol-12-myristate-13-acetate (a PKC activator) induced it.	calphostin C	10-22	protein kinase C, alpha	Rattus norvegicus	26-29
19672103-7	2010	Moreover, calphostin C (a PKC inhibitor) inhibited TGF-beta(1)-induced alpha-SMA expression, whereas phorbol-12-myristate-13-acetate (a PKC activator) induced it.	calphostin C	10-22	transforming growth factor, beta 1	Rattus norvegicus	51-62
19672103-7	2010	Moreover, calphostin C (a PKC inhibitor) inhibited TGF-beta(1)-induced alpha-SMA expression, whereas phorbol-12-myristate-13-acetate (a PKC activator) induced it.	calphostin C	10-22	actin gamma 2, smooth muscle	Rattus norvegicus	77-80
19111928-6	2009	Palmitate effect on NF-kappaB gene and protein expression was found to be mediated by phospho-PKCepsilon as calphostin C (an inhibitor of PKC) and epsilonV1 (PKCepsilon translocation inhibitor) significantly reduced NF-kappaB expression.	calphostin C	108-120	nuclear factor kappa B subunit 1	Homo sapiens	20-29
19895572-6	2010	Inhibitors which bind to diacylglycerol (DAG) or Ca(2+)-binding sites of PKC (calphostin C and Go6967) had no effect.	calphostin C	78-90	protein kinase C alpha	Homo sapiens	73-76
19741016-7	2009	Exposure to calphostin C or chelerythrine (PKC inhibitors), Go6976 (PKCalpha/beta inhibitor), or rottlerin (PKCdelta inhibitor) decreased O2*- production to <20% of untreated baseline in both normal/sham and STZ mTALs.	calphostin C	12-24	protein kinase C, alpha	Rattus norvegicus	43-46
19615994-8	2009	On the other hand, the bronchial smooth muscle contraction by endothelin-1 was significantly inhibited by GF109203X, calphostin C and Go6976 but not by rottlerin.	calphostin C	117-129	endothelin 1	Rattus norvegicus	62-74
19698232-5	2009	Calphostin C could inhibit the above reaction resulted from PKC activation.	calphostin C	0-12	proline rich transmembrane protein 2	Homo sapiens	60-63
19111928-6	2009	Palmitate effect on NF-kappaB gene and protein expression was found to be mediated by phospho-PKCepsilon as calphostin C (an inhibitor of PKC) and epsilonV1 (PKCepsilon translocation inhibitor) significantly reduced NF-kappaB expression.	calphostin C	108-120	protein kinase C epsilon	Homo sapiens	94-104
19111928-6	2009	Palmitate effect on NF-kappaB gene and protein expression was found to be mediated by phospho-PKCepsilon as calphostin C (an inhibitor of PKC) and epsilonV1 (PKCepsilon translocation inhibitor) significantly reduced NF-kappaB expression.	calphostin C	108-120	protein kinase C epsilon	Homo sapiens	94-97
19014523-10	2008	Calphostin C, a specific inhibitor of protein kinase C (PKC), greatly decreased bile acid induced MUC2 transcription and Nuclear factor-kappaB activity, whereas inhibitors of MAP kinase had no effect.	calphostin C	0-12	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	98-102
19121332-9	2009	Calphostin C, an inhibitor of PKC alpha, showed a significant inhibition of PKC alpha activity in the presence of TCDD.	calphostin C	0-12	protein kinase C alpha	Homo sapiens	30-39
19121332-9	2009	Calphostin C, an inhibitor of PKC alpha, showed a significant inhibition of PKC alpha activity in the presence of TCDD.	calphostin C	0-12	protein kinase C alpha	Homo sapiens	76-85
20731935-5	2008	The distribution of PKC alpha in cytosol and plasma membrane and translocation were detected among different metastatic potential human pulmonary carcinoma cells L9981, L9981-pLXSN and L9981-nm23-H1 before and after treatment with PKC inhibitor Calphostin C, by Western blot and LSCM.	calphostin C	245-257	protein kinase C alpha	Homo sapiens	20-29
18524939-8	2008	Both Y27632 (Rho-kinase inhibitor) and calphostin C (PKC inhibitor) reduced CCh-dependent force, RLC phosphorylation, and phosphorylation of MYPT1 (Thr694) without changing MLCK activation.	calphostin C	39-51	protein phosphatase 1, regulatory subunit 12A	Mus musculus	141-146
18524939-8	2008	Both Y27632 (Rho-kinase inhibitor) and calphostin C (PKC inhibitor) reduced CCh-dependent force, RLC phosphorylation, and phosphorylation of MYPT1 (Thr694) without changing MLCK activation.	calphostin C	39-51	myosin light chain kinase 3	Mus musculus	173-177
18621151-8	2008	Protein kinase C inhibitors (Ro 31-8220, calphostin C, staurosporine, and chelerythrine chloride) also inhibited LPS-induced c-fos transcription.	calphostin C	41-53	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-130
18497756-0	2008	Calphostin C-induced apoptosis is mediated by a tissue transglutaminase-dependent mechanism involving the DLK/JNK signaling pathway.	calphostin C	0-12	transglutaminase 2	Homo sapiens	48-71
18497756-0	2008	Calphostin C-induced apoptosis is mediated by a tissue transglutaminase-dependent mechanism involving the DLK/JNK signaling pathway.	calphostin C	0-12	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	106-109
18497756-0	2008	Calphostin C-induced apoptosis is mediated by a tissue transglutaminase-dependent mechanism involving the DLK/JNK signaling pathway.	calphostin C	0-12	mitogen-activated protein kinase 8	Homo sapiens	110-113
18497756-5	2008	Importantly, combined depletion of TG2 and DLK further alters calphostin C effects on JNK activity, Bax translocation, caspase-3 activation, PARP cleavage and cell viability, demonstrating an obligatory role for TG2 and DLK in calphostin C-induced apoptosis.	calphostin C	62-74	transglutaminase 2, C polypeptide	Mus musculus	35-38
18497756-5	2008	Importantly, combined depletion of TG2 and DLK further alters calphostin C effects on JNK activity, Bax translocation, caspase-3 activation, PARP cleavage and cell viability, demonstrating an obligatory role for TG2 and DLK in calphostin C-induced apoptosis.	calphostin C	62-74	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	43-46
18497756-5	2008	Importantly, combined depletion of TG2 and DLK further alters calphostin C effects on JNK activity, Bax translocation, caspase-3 activation, PARP cleavage and cell viability, demonstrating an obligatory role for TG2 and DLK in calphostin C-induced apoptosis.	calphostin C	62-74	mitogen-activated protein kinase 8	Homo sapiens	86-89
17766169-7	2008	Treatment with calphostin C, an inhibitor of protein kinase C, decreased the expression of vascular endothelial growth factor receptor 2.	calphostin C	15-27	kinase insert domain receptor	Gallus gallus	91-136
18245203-6	2008	The stimulatory effects of Ang(1-7) and PMA on Na+-ATPase activity are similar, non-additive and reversed by calphostin C, a specific inhibitor of PKC.	calphostin C	109-121	PKC	Sus scrofa	147-150
18164589-7	2008	Stimulation of glucose uptake and induction of GLUT4 translocation in cardiac myocytes by contraction and oligomycin each were sensitive to inhibition by the PKC/PKD inhibitors staurosporin and calphostin-C.	calphostin C	194-206	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	47-52
18164589-7	2008	Stimulation of glucose uptake and induction of GLUT4 translocation in cardiac myocytes by contraction and oligomycin each were sensitive to inhibition by the PKC/PKD inhibitors staurosporin and calphostin-C.	calphostin C	194-206	protein kinase D1	Mus musculus	162-165
17996892-8	2008	The effect of NPY (250 nM) on vagal bradycardia was abolished by the PKC inhibitors calphostin C (0.1 microM, n=5) and chelerythrine chloride (25 microM, n=6) but not the PKA inhibitor H89 (0.5 microM, n=6).	calphostin C	84-96	pro-neuropeptide Y	Cavia porcellus	14-17
17532611-5	2007	ROS formation was also attenuated by trifluoroacetyl arachidonic acid (10 microM), a specific inhibitor of cytosolic phospholipase A2, U-73122 (5 microM) and D609 (200 microM), inhibitors of phospholipase C and calphostin C (300 nM), a highly specific inhibitor of protein kinase C (PKC), all known activators of NADPH oxidase.	calphostin C	211-223	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	107-133
17945434-7	2007	The steady-state levels of full-length APP and cell viability were unaffected by Hup A. Alpha-APPs release induced by Hup A treatment was significantly reduced by muscarinic acetylcholine receptor antagonists (particularly by an M1 antagonist), protein kinase C (PKC) inhibitors, GF109203X and calphostin C, and the mitogen-activated kinase kinase (MEK) inhibitors, U0126 and PD98059.	calphostin C	294-306	cathepsin B	Homo sapiens	94-98
17919561-10	2007	Carbachol-stimulated MAPK activity was inhibited by three PKC inhibitors, calphostin C, chelethyrine, and staurosporine.	calphostin C	74-86	mitogen activated protein kinase 3	Rattus norvegicus	21-25
17639599-10	2007	Treatment with the PKC activator PMA (10-50 nM) stimulated GRO secretion, and the PKC inhibitors calphostin C (300 nM) or chelerythrine (1 microM) attenuated the high glucose-induced GRO secretion.	calphostin C	97-109	C-X-C motif chemokine ligand 1	Rattus norvegicus	183-186
17586469-4	2007	Expressed in COS-1 cells, mouse GI-distributed Ugt1a1 glucuronidates curcumin and MPA and undergoes irreversibly and reversibly dephosphorylation by PKC-specific inhibitor calphostin-C and general-kinase inhibitor curcumin, respectively, with parallel effects on activity.	calphostin C	172-184	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	47-53
17983652-8	2008	The Ca(2+)-dependent protein kinase C (PKC) was also activated in EEC after calcitonin treatment, and the PKC inhibitors staurosporine and calphostin C could completely abolish calcitonin-induced augmentation of trophoblast expansion on EEC.	calphostin C	139-151	calcitonin related polypeptide alpha	Homo sapiens	76-86
17983652-8	2008	The Ca(2+)-dependent protein kinase C (PKC) was also activated in EEC after calcitonin treatment, and the PKC inhibitors staurosporine and calphostin C could completely abolish calcitonin-induced augmentation of trophoblast expansion on EEC.	calphostin C	139-151	calcitonin related polypeptide alpha	Homo sapiens	177-187
17545677-10	2007	The addition of calphostin C (PKC inhibitor) or Rp-cAMP (PKA inhibitor) reduced the eNOS mRNA, protein expression and activity of PTH-stimulated HUVEC.	calphostin C	16-28	nitric oxide synthase 3	Homo sapiens	84-88
17545677-10	2007	The addition of calphostin C (PKC inhibitor) or Rp-cAMP (PKA inhibitor) reduced the eNOS mRNA, protein expression and activity of PTH-stimulated HUVEC.	calphostin C	16-28	parathyroid hormone	Homo sapiens	130-133
17105827-8	2007	PKC inhibition by calphostin C (10 microM) blocked these effects, whereas activation by PMA reduced basal PPARalpha expression.	calphostin C	18-30	proline rich transmembrane protein 2	Homo sapiens	0-3
17549394-8	2007	SQ-22536, U-73122, the protein kinase (PK) A inhibitor H-89 and the PKC inhibitor calphostin-C decreased by approximately 50% the cortisol response of dispersed cells to IGF-I, and the combined exposure to SQ-22536 and U-73122 abolished it.	calphostin C	82-94	insulin-like growth factor I	Cavia porcellus	170-175
17267548-7	2007	The augmented RyR and NCX activities were abolished, respectively, by PKA inhibitor (0.5 microM KT5720 or 0.5 microM PKI(14-22)) and PKC inhibitor (5 microM chelerythrine chloride or 0.2 microM calphostin C) but not by Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-93 (1 microM).	calphostin C	194-206	ryanodine receptor 2	Rattus norvegicus	14-17
17267548-7	2007	The augmented RyR and NCX activities were abolished, respectively, by PKA inhibitor (0.5 microM KT5720 or 0.5 microM PKI(14-22)) and PKC inhibitor (5 microM chelerythrine chloride or 0.2 microM calphostin C) but not by Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-93 (1 microM).	calphostin C	194-206	solute carrier family 8 member A1	Rattus norvegicus	22-25
16949756-8	2007	These PKC modulators had similar effects on TCS-induced cleavage of caspase-3, and caspase-3 inhibitors prevented calphostin c-enhanced apoptosis induced by TCS.	calphostin C	114-126	caspase 3	Homo sapiens	83-92
18034874-10	2007	In line with the general protein kinase C (PKC) inhibitor calphostin C, Go6976 (a Ca2+-dependent PKC inhibitor) diminished TGF-beta1-induced Ank expression by 60%, whereas a 10% inhibition was observed with rottlerin (a PKCdelta inhibitor).	calphostin C	58-70	protein kinase C delta	Homo sapiens	43-46
18034874-10	2007	In line with the general protein kinase C (PKC) inhibitor calphostin C, Go6976 (a Ca2+-dependent PKC inhibitor) diminished TGF-beta1-induced Ank expression by 60%, whereas a 10% inhibition was observed with rottlerin (a PKCdelta inhibitor).	calphostin C	58-70	transforming growth factor beta 1	Homo sapiens	123-132
17098545-11	2006	This effect was sustained when cells were treated with L-NAME (32% +/- 1.6% increase, P = .02) but abolished when endothelial cells were treated with calphostin C or PD98059 to block protein kinase C (PKC) or extracellular regulated kinase (ERK).	calphostin C	150-162	mitogen-activated protein kinase 1	Homo sapiens	209-239
17098545-11	2006	This effect was sustained when cells were treated with L-NAME (32% +/- 1.6% increase, P = .02) but abolished when endothelial cells were treated with calphostin C or PD98059 to block protein kinase C (PKC) or extracellular regulated kinase (ERK).	calphostin C	150-162	mitogen-activated protein kinase 1	Homo sapiens	241-244
16886117-9	2006	Compared with 5-Fu alone, the growth suppression rate of FasL-positive colorectal carcinoma HR-8348 cells was significantly raised by sFas-Calphostin C combined with 5-Fu.	calphostin C	139-151	Fas ligand	Homo sapiens	57-61
17090476-2	2006	The authors determined the time course of activation and downregulation of PKCepsilon by the known PKC activator phorbol 12-myristate 13-acetate (PMA) and demonstrate that chemical inhibition of PKC by calphostin C or the novel PKC isoform inhibitor Ro 31-8220 induced striking detachment of ciliated BBECs from the basal cell monolayer within 1 hour, independent of apoptosis or necrotic cell death.	calphostin C	202-214	protein kinase C epsilon	Bos taurus	75-78
16798739-7	2006	This effect was blocked by the pan-specific PKC inhibitors RO 31-8220 and bisindolylmaleimide I, partially blocked by Go 6976, and was unaffected by the PKCzeta-sparing inhibitor calphostin C.	calphostin C	179-191	protein kinase C zeta	Homo sapiens	44-47
16833194-5	2006	Calphostin C, one inhibitor of the protein kinase C (PKC), could block IL-6-induced AR in human sperm.	calphostin C	0-12	interleukin 6	Homo sapiens	71-75
16431170-8	2006	Of note, calphostin C showed inhibitory effects on the activation of p38 MAPK, ERK and also PKB, whereas it exerted no effect on JNK activation.	calphostin C	9-21	mitogen-activated protein kinase 1	Homo sapiens	79-82
16484320-5	2006	Both H-89, a specific PKA inhibitor, and PKC inhibitors, staurosporine and calphostin C, antagonized PTH stimulation of beta-catenin levels.	calphostin C	75-87	parathyroid hormone	Mus musculus	101-104
16631733-5	2006	Calphostin C (1 microM) and LY379196 (10 microM) reduced nitrite levels and iNOS expression only in cells from normotensive rats treated with both media.	calphostin C	0-12	nitric oxide synthase 2	Rattus norvegicus	76-80
16484320-5	2006	Both H-89, a specific PKA inhibitor, and PKC inhibitors, staurosporine and calphostin C, antagonized PTH stimulation of beta-catenin levels.	calphostin C	75-87	catenin (cadherin associated protein), beta 1	Mus musculus	120-132
16374778-4	2006	Phagocytosis by CR3/MAC-1 and SRAI/II was inhibited by cPKC inhibitor Go-6976, general-PKC inhibitors Ro-318220 and calphostin-C, and BAPTA/AM, which chelates intracellular Ca2+ required for cPKC activation.	calphostin C	116-128	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	16-19
16623718-6	2006	Classical and novel PKC isoforms could be excluded by treatment of the cells with Go6976 and calphostin C, whereas addition of a myristoylated PKCzeta pseudosubstrate inhibitor completely abolished P2Y(12) receptor-induced ERK1/2 activation.	calphostin C	93-105	protein kinase C zeta	Homo sapiens	20-23
16374778-4	2006	Phagocytosis by CR3/MAC-1 and SRAI/II was inhibited by cPKC inhibitor Go-6976, general-PKC inhibitors Ro-318220 and calphostin-C, and BAPTA/AM, which chelates intracellular Ca2+ required for cPKC activation.	calphostin C	116-128	integrin subunit alpha M	Homo sapiens	20-25
16311911-3	2005	Pretreatment with calphostin C (a general PKC inhibitor) and rottlerin (a PKCdelta inhibitor) prevented the increase in PKC activity and reversed O2 *- caused inhibition of Na+ dependent Ca2+ uptake without causing any change in MMP-2 activity in the microsomes of the smooth muscle.	calphostin C	18-30	matrix metallopeptidase 2	Bos taurus	229-234
16169898-6	2006	Pretreatment of cells with PKC inhibitors, including RO-32-0432, calphostin C, and bisindolylmaleimide I, inhibited silica-induced AP-1 activation and phosphorylation of ERKs and p38 kinase.	calphostin C	65-77	protein kinase C alpha	Homo sapiens	27-30
16169898-6	2006	Pretreatment of cells with PKC inhibitors, including RO-32-0432, calphostin C, and bisindolylmaleimide I, inhibited silica-induced AP-1 activation and phosphorylation of ERKs and p38 kinase.	calphostin C	65-77	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-135
16169898-6	2006	Pretreatment of cells with PKC inhibitors, including RO-32-0432, calphostin C, and bisindolylmaleimide I, inhibited silica-induced AP-1 activation and phosphorylation of ERKs and p38 kinase.	calphostin C	65-77	mitogen-activated protein kinase 14	Homo sapiens	179-182
16190878-8	2005	Infusion of calphostin C, a selective protein kinase C inhibitor, produced a reduction in the morphine withdrawal-induced c-Fos expression.	calphostin C	12-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	122-127
16043016-4	2005	This increase was completely blocked by the treatment with pitavastatin (5 x 10(-7)M) as well as a NAD(P)H oxidase inhibitor (diphenylene iodonium) or a PKC inhibitor (calphostin C) in parallel with the change of small GTPase Rac-1 activity, a cytosolic regulatory component of NAD(P)H oxidase.	calphostin C	168-180	Rac family small GTPase 1	Rattus norvegicus	226-231
15880462-5	2005	Furthermore, pretreatment with calphostin C, a selective protein kinase C (PKC) inhibitor, blocked A23187-dependent dephosphorylation of histone H3-Ser10, and coimmunoprecipitation analysis showed PP2A association with the PKCbetaII isoform.	calphostin C	31-43	protein phosphatase 2 phosphatase activator	Homo sapiens	197-201
16164449-12	2005	Calphostin C, wortmannin and manoalide attenuated CD62L down-regulation, suggesting the potential implication of protein kinase C, phosphatidylinositol 3-kinase and phospholipase A(2) in the process.	calphostin C	0-12	selectin L	Homo sapiens	50-55
16164449-12	2005	Calphostin C, wortmannin and manoalide attenuated CD62L down-regulation, suggesting the potential implication of protein kinase C, phosphatidylinositol 3-kinase and phospholipase A(2) in the process.	calphostin C	0-12	phospholipase A2 group IB	Homo sapiens	165-182
16054131-7	2005	These effects induced by FBS or EGF were attenuated in the presence of protein kinase C (PKC) inhibitors calphostin C and bisindolylmaleimide I, but not another PKC inhibitor Go6976, PD98059 (MAPK inhibitor), LY294002 (PI3 kinase inhibitor) or KT5720 (protein kinase A inhibitor).	calphostin C	105-117	epidermal growth factor	Homo sapiens	32-35
16150575-10	2005	Carbamazepine-increased EAAT3 activity was inhibited by wortmannin or LY-294002, phosphatidylinositol 3-kinase (PI3K) inhibitors, but was not affected by staurosporine, chelerythrine or calphostin C, protein kinase C inhibitors.	calphostin C	186-198	solute carrier family 1 member 1	Rattus norvegicus	24-29
15799972-6	2005	Treatment with wortmannin or calphostin C or the expression of dominant negative Akt inhibited phosphorylation of GSK-3beta at Ser-9 following the KCl-induced depolarization of SH-SY5Y cells.	calphostin C	29-41	glycogen synthase kinase 3 beta	Homo sapiens	114-123
15927719-7	2005	Involvement of the protein kinase C (PKC) was evidenced by the sensitivity of the inhibitory effect of Ang-(1-7) to calphostin C (6.32 x 10(-7) M) and the lack of additive effects when the cells were co-incubated with Ang-(1-7) and 3.2 x 10(-8) M PMA.	calphostin C	116-128	angiopoietin 1	Canis lupus familiaris	103-111
15888667-4	2005	Moreover, blockade of Raf, MEK1/2, or PKC activation with geldanamycin, U0126, or calphostin C inhibited ERK1/2 phosphorylation, demonstrating a PKC-Raf-MEK1/2 pathway.	calphostin C	82-94	mitogen-activated protein kinase 3	Homo sapiens	105-111
15888667-4	2005	Moreover, blockade of Raf, MEK1/2, or PKC activation with geldanamycin, U0126, or calphostin C inhibited ERK1/2 phosphorylation, demonstrating a PKC-Raf-MEK1/2 pathway.	calphostin C	82-94	zinc fingers and homeoboxes 2	Homo sapiens	149-152
15888667-4	2005	Moreover, blockade of Raf, MEK1/2, or PKC activation with geldanamycin, U0126, or calphostin C inhibited ERK1/2 phosphorylation, demonstrating a PKC-Raf-MEK1/2 pathway.	calphostin C	82-94	mitogen-activated protein kinase kinase 1	Homo sapiens	153-159
15797961-5	2005	Cortisol response to NPB was lowered by either SQ-22536 and the protein kinase (PK) A inhibitor H-89 or U-73122 and the PKC inhibitor calphostin-C and abolished by the simultaneous exposure to H-89 and calphostin-C.	calphostin C	134-146	neuropeptide B	Homo sapiens	21-24
15797961-5	2005	Cortisol response to NPB was lowered by either SQ-22536 and the protein kinase (PK) A inhibitor H-89 or U-73122 and the PKC inhibitor calphostin-C and abolished by the simultaneous exposure to H-89 and calphostin-C.	calphostin C	202-214	neuropeptide B	Homo sapiens	21-24
15784626-7	2005	These effects were sensitive to hCGRP(8-37), calphostin C (a protein kinase C (PKC) inhibitor), and 5-hydroxydecanoic acid (a mitochondrial K(+)(ATP) channel blocker) but were insensitive to protein kinase A blockers.	calphostin C	45-57	protein kinase C epsilon	Homo sapiens	79-82
15767261-3	2005	We show here that the antiapoptotic activity of the AR/IGF1 combination is specifically abolished by the PKC inhibitors calphostin C and staurosporine, but not by the MAPK and phosphatidylinositol 3-kinase inhibitors PD98059 and wortmannin, suggesting the involvement of a PKC-dependent and MAPK- and phosphatidylinositol 3-kinase-independent survival pathway.	calphostin C	120-132	amphiregulin	Homo sapiens	52-54
15767261-3	2005	We show here that the antiapoptotic activity of the AR/IGF1 combination is specifically abolished by the PKC inhibitors calphostin C and staurosporine, but not by the MAPK and phosphatidylinositol 3-kinase inhibitors PD98059 and wortmannin, suggesting the involvement of a PKC-dependent and MAPK- and phosphatidylinositol 3-kinase-independent survival pathway.	calphostin C	120-132	insulin like growth factor 1	Homo sapiens	55-59
15767261-3	2005	We show here that the antiapoptotic activity of the AR/IGF1 combination is specifically abolished by the PKC inhibitors calphostin C and staurosporine, but not by the MAPK and phosphatidylinositol 3-kinase inhibitors PD98059 and wortmannin, suggesting the involvement of a PKC-dependent and MAPK- and phosphatidylinositol 3-kinase-independent survival pathway.	calphostin C	120-132	protein kinase C delta	Homo sapiens	105-108
15632825-3	2005	This study aimed to evaluate the effect of calphostin C (a protein kinase C inhibitor) on trichostatin A (a histone deacetylase inhibitor)-mediated upregulation of nuclear factor kappaB and p21 promotor transcriptional activity, as well as induction of apoptosis in lung and esophageal cancer cells.	calphostin C	43-55	H3 histone pseudogene 16	Homo sapiens	190-193
15829628-5	2005	This interaction between mGluR1/5 and DR1/5 required protein kinase C (PKC), because the PKC inhibitors calphostin C, bisindolylmaleimide I, and Go6976 blocked DR1/5-enhanced phosphorylation of ERK2.	calphostin C	104-116	glutamate metabotropic receptor 1	Homo sapiens	25-31
15829628-5	2005	This interaction between mGluR1/5 and DR1/5 required protein kinase C (PKC), because the PKC inhibitors calphostin C, bisindolylmaleimide I, and Go6976 blocked DR1/5-enhanced phosphorylation of ERK2.	calphostin C	104-116	down-regulator of transcription 1	Homo sapiens	38-43
15829628-5	2005	This interaction between mGluR1/5 and DR1/5 required protein kinase C (PKC), because the PKC inhibitors calphostin C, bisindolylmaleimide I, and Go6976 blocked DR1/5-enhanced phosphorylation of ERK2.	calphostin C	104-116	down-regulator of transcription 1	Homo sapiens	38-41
15829628-5	2005	This interaction between mGluR1/5 and DR1/5 required protein kinase C (PKC), because the PKC inhibitors calphostin C, bisindolylmaleimide I, and Go6976 blocked DR1/5-enhanced phosphorylation of ERK2.	calphostin C	104-116	mitogen-activated protein kinase 1	Homo sapiens	194-198
15637072-10	2005	(v) The specific protein kinase C (PKC) inhibitors chelerythrine chloride or calphostin C completely blocked the inhibition by 5-HT.	calphostin C	77-89	protein kinase C delta	Homo sapiens	35-38
15543559-6	2005	On the other hand, calphostin C, an inhibitor of protein kinase C (PKC), reduced the thrombin-induced p38 MAP kinase phosphorylation, and significantly suppressed the thrombin-stimulated accumulation of HSP27.	calphostin C	19-31	coagulation factor II, thrombin	Homo sapiens	85-93
15543559-6	2005	On the other hand, calphostin C, an inhibitor of protein kinase C (PKC), reduced the thrombin-induced p38 MAP kinase phosphorylation, and significantly suppressed the thrombin-stimulated accumulation of HSP27.	calphostin C	19-31	mitogen-activated protein kinase 14	Homo sapiens	102-105
15543559-6	2005	On the other hand, calphostin C, an inhibitor of protein kinase C (PKC), reduced the thrombin-induced p38 MAP kinase phosphorylation, and significantly suppressed the thrombin-stimulated accumulation of HSP27.	calphostin C	19-31	coagulation factor II, thrombin	Homo sapiens	167-175
15543559-6	2005	On the other hand, calphostin C, an inhibitor of protein kinase C (PKC), reduced the thrombin-induced p38 MAP kinase phosphorylation, and significantly suppressed the thrombin-stimulated accumulation of HSP27.	calphostin C	19-31	heat shock protein family B (small) member 1	Homo sapiens	203-208
15796067-4	2005	The amitriptyline-induced GDNF release was completely inhibited by U0126, a mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89, a protein kinase A inhibitor or calphostin C, a protein kinase C inhibitor.	calphostin C	247-259	glial cell derived neurotrophic factor	Rattus norvegicus	26-30
15836625-13	2005	Moreover, a protein kinase C inhibitor, calphostin C, dramatically suppressed IL-6 release, whereas a protein kinase A inhibitor H-89 and a Ca2+ chelator EGTA failed.	calphostin C	40-52	interleukin 6	Homo sapiens	78-82
15632825-10	2005	Treatment with trichostatin A and calphostin C led to a 50% to 90% decrease of trichostatin A- mediated upregulation of nuclear factor kappaB and p21 activation.	calphostin C	34-46	H3 histone pseudogene 16	Homo sapiens	146-149
15381257-5	2004	This depolarisation depended on the activation of protein kinase Czeta (PKCzeta), because it can be blocked by calphostin C, a PKC-inhibitory peptide and a specific inhibitor peptide for PKCzeta.	calphostin C	111-123	protein kinase C, zeta	Rattus norvegicus	187-194
16293985-5	2005	Reduced thrombin-induced VEGF secretion upon treatment with LY294002, calphostin C, or BAPTA, further suggests that the process is dependent on phosphatidyl-inositol-3-kinase, protein kinase C, and calcium.	calphostin C	70-82	coagulation factor II, thrombin	Homo sapiens	8-16
16293985-5	2005	Reduced thrombin-induced VEGF secretion upon treatment with LY294002, calphostin C, or BAPTA, further suggests that the process is dependent on phosphatidyl-inositol-3-kinase, protein kinase C, and calcium.	calphostin C	70-82	vascular endothelial growth factor A	Homo sapiens	25-29
15381257-5	2004	This depolarisation depended on the activation of protein kinase Czeta (PKCzeta), because it can be blocked by calphostin C, a PKC-inhibitory peptide and a specific inhibitor peptide for PKCzeta.	calphostin C	111-123	protein kinase C, zeta	Rattus norvegicus	50-70
15381257-5	2004	This depolarisation depended on the activation of protein kinase Czeta (PKCzeta), because it can be blocked by calphostin C, a PKC-inhibitory peptide and a specific inhibitor peptide for PKCzeta.	calphostin C	111-123	protein kinase C, zeta	Rattus norvegicus	72-79
15143153-11	2004	Activation of PKCtheta contributes to IKK and JNK activation as inhibition of PKCtheta by calphostin C blocked activation of the latter kinases.	calphostin C	90-102	protein kinase C, theta	Mus musculus	14-22
15381257-5	2004	This depolarisation depended on the activation of protein kinase Czeta (PKCzeta), because it can be blocked by calphostin C, a PKC-inhibitory peptide and a specific inhibitor peptide for PKCzeta.	calphostin C	111-123	protein kinase C, zeta	Rattus norvegicus	72-75
15297444-6	2004	The NE-induced increase in MKK3/6 and p38MAPK phosphorylation was blocked by KT5720 (a protein kinase A inhibitor) and KN93 (a Ca(2+)/calmodulin-dependent kinase inhibitor), but not by KT5823 (a protein kinase G inhibitor) or calphostin C (a protein kinase C inhibitor).	calphostin C	226-238	mitogen activated protein kinase kinase 3	Rattus norvegicus	27-33
15591778-5	2004	Both ACh and PMA increased phosphorylation of PLD1 that was significantly blocked by genistein or the PKC inhibitor calphostin C.	calphostin C	116-128	phospholipase D1	Homo sapiens	46-50
15494525-3	2004	In this study calphostin C, an inhibitor for both novel PKC (including PKCdelta, -epsilon, -theta;, and -eta) and conventional PKC (including PKCalpha and -beta), inhibited both phosphorylation and translocation of p47phox, an essential component of the monocyte NADPH oxidase.	calphostin C	14-26	protein kinase C delta	Homo sapiens	56-59
15494525-3	2004	In this study calphostin C, an inhibitor for both novel PKC (including PKCdelta, -epsilon, -theta;, and -eta) and conventional PKC (including PKCalpha and -beta), inhibited both phosphorylation and translocation of p47phox, an essential component of the monocyte NADPH oxidase.	calphostin C	14-26	protein kinase C delta	Homo sapiens	71-108
15494525-3	2004	In this study calphostin C, an inhibitor for both novel PKC (including PKCdelta, -epsilon, -theta;, and -eta) and conventional PKC (including PKCalpha and -beta), inhibited both phosphorylation and translocation of p47phox, an essential component of the monocyte NADPH oxidase.	calphostin C	14-26	protein kinase C delta	Homo sapiens	71-74
15494525-3	2004	In this study calphostin C, an inhibitor for both novel PKC (including PKCdelta, -epsilon, -theta;, and -eta) and conventional PKC (including PKCalpha and -beta), inhibited both phosphorylation and translocation of p47phox, an essential component of the monocyte NADPH oxidase.	calphostin C	14-26	protein kinase C alpha	Homo sapiens	142-160
15494525-3	2004	In this study calphostin C, an inhibitor for both novel PKC (including PKCdelta, -epsilon, -theta;, and -eta) and conventional PKC (including PKCalpha and -beta), inhibited both phosphorylation and translocation of p47phox, an essential component of the monocyte NADPH oxidase.	calphostin C	14-26	neutrophil cytosolic factor 1	Homo sapiens	215-222
15350848-9	2004	Western blot analysis showed that OA-induced Cx43 Ser368 phosphorylation, and that this effect could be blocked by cotreatment with the general PKC inhibitor, calphostin C, the PKC inhibitor, eV1-2, or the Src kinase inhibitor, PP1, but not by the PKCalpha inhibitor, Go6976.	calphostin C	159-171	gap junction protein, alpha 1	Rattus norvegicus	45-49
15350848-9	2004	Western blot analysis showed that OA-induced Cx43 Ser368 phosphorylation, and that this effect could be blocked by cotreatment with the general PKC inhibitor, calphostin C, the PKC inhibitor, eV1-2, or the Src kinase inhibitor, PP1, but not by the PKCalpha inhibitor, Go6976.	calphostin C	159-171	protein kinase C, gamma	Rattus norvegicus	177-180
15350848-9	2004	Western blot analysis showed that OA-induced Cx43 Ser368 phosphorylation, and that this effect could be blocked by cotreatment with the general PKC inhibitor, calphostin C, the PKC inhibitor, eV1-2, or the Src kinase inhibitor, PP1, but not by the PKCalpha inhibitor, Go6976.	calphostin C	159-171	neuropeptide Y receptor Y4	Rattus norvegicus	228-231
15350848-9	2004	Western blot analysis showed that OA-induced Cx43 Ser368 phosphorylation, and that this effect could be blocked by cotreatment with the general PKC inhibitor, calphostin C, the PKC inhibitor, eV1-2, or the Src kinase inhibitor, PP1, but not by the PKCalpha inhibitor, Go6976.	calphostin C	159-171	protein kinase C, alpha	Rattus norvegicus	248-256
15212812-6	2004	Moreover, Cd stimulated the phosphorylation of these three MAPKs, and inhibition of the phosphorylation of ERK1/2 MAPK by calphostin C was also observed.	calphostin C	122-134	mitogen-activated protein kinase 3	Mus musculus	107-113
15251861-7	2004	The pressor effect of ANG II was blunted (P < 0.05) in kidneys perfused with buffer containing losartan (10 micromol/l) or PKC inhibitors staurosporine (0.1 micromol/l) or calphostin C (1 micromol/l).	calphostin C	175-187	angiotensinogen	Rattus norvegicus	22-28
15143153-11	2004	Activation of PKCtheta contributes to IKK and JNK activation as inhibition of PKCtheta by calphostin C blocked activation of the latter kinases.	calphostin C	90-102	mitogen-activated protein kinase 8	Mus musculus	46-49
15143153-11	2004	Activation of PKCtheta contributes to IKK and JNK activation as inhibition of PKCtheta by calphostin C blocked activation of the latter kinases.	calphostin C	90-102	protein kinase C, theta	Mus musculus	78-86
15175028-7	2004	EGF-mediated induction of fibronectin expression was inhibited by the treatment of fibroblasts with protein kinase C (PKC) inhibitor, Calphostin C and Rottlerin.	calphostin C	134-146	epidermal growth factor	Homo sapiens	0-3
15175028-7	2004	EGF-mediated induction of fibronectin expression was inhibited by the treatment of fibroblasts with protein kinase C (PKC) inhibitor, Calphostin C and Rottlerin.	calphostin C	134-146	fibronectin 1	Homo sapiens	26-37
21214997-6	2004	PKC-alpha and PKC-betaII mainly located in cytosolic fraction and were in inactive status in all the three cell lines after treatment with Calphostin C.	calphostin C	139-151	protein kinase C alpha	Homo sapiens	0-9
15150589-3	2004	Proteasome expression induced by PIF was attenuated by 4alpha-phorbol 12-myristate 13-acetate (100 nM) and by the PKC inhibitors Ro31-8220 (10 microM), staurosporine (300 nM), calphostin C (300 nM) and Go 6976 (200 microM).	calphostin C	176-188	Pif	Mus musculus	33-36
15150589-3	2004	Proteasome expression induced by PIF was attenuated by 4alpha-phorbol 12-myristate 13-acetate (100 nM) and by the PKC inhibitors Ro31-8220 (10 microM), staurosporine (300 nM), calphostin C (300 nM) and Go 6976 (200 microM).	calphostin C	176-188	protein kinase C, alpha	Mus musculus	114-117
14739943-6	2004	Moreover, functional studies demonstrate that tTG-mediated oligomerization of wild-type DLK sensitizes cells to calphostin C-induced apoptosis, while crosslinking of a kinase-inactive variant of DLK does not.	calphostin C	112-124	transglutaminase 2	Homo sapiens	46-49
14739943-6	2004	Moreover, functional studies demonstrate that tTG-mediated oligomerization of wild-type DLK sensitizes cells to calphostin C-induced apoptosis, while crosslinking of a kinase-inactive variant of DLK does not.	calphostin C	112-124	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	88-91
15150589-7	2004	Proteolysis-inducing factor induced a decrease in cytosolic I-kappaBalpha and an increase in nuclear binding of NF-kappaB in pCO(2), but not in pKS1, and the effect in wild-type cells was attenuated by calphostin C, confirming that it was mediated through PKC.	calphostin C	202-214	Pif	Mus musculus	0-27
15150589-7	2004	Proteolysis-inducing factor induced a decrease in cytosolic I-kappaBalpha and an increase in nuclear binding of NF-kappaB in pCO(2), but not in pKS1, and the effect in wild-type cells was attenuated by calphostin C, confirming that it was mediated through PKC.	calphostin C	202-214	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-121
21214997-6	2004	PKC-alpha and PKC-betaII mainly located in cytosolic fraction and were in inactive status in all the three cell lines after treatment with Calphostin C.	calphostin C	139-151	proline rich transmembrane protein 2	Homo sapiens	0-3
14981072-6	2004	ET-1 caused translocation of Ca2+-dependent alpha-PKC and Ca2+-independent epsilon-PKC from the cytosolic to the particulate fraction that was inhibited by calphostin C.	calphostin C	156-168	endothelin 1	Homo sapiens	0-4
14660552-4	2004	We show here that apoptosis is inhibited by the addition of exogenous phosphatidic acid, a metabolite of phospholipase D (PLD), and that calphostin-C inhibits completely the activities of both isoforms of PLD, PLD1 and PLD2.	calphostin C	137-149	phospholipase D1	Cricetulus griseus	210-214
15142358-6	2004	The elevated basal pKC activity in diseased thyrocytes was related to their enhanced production of soluble TNF-R1 because inhibition of pKC activity with calphostin C caused soluble TNF-R1 production to decrease significantly.	calphostin C	154-166	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	107-113
15142358-6	2004	The elevated basal pKC activity in diseased thyrocytes was related to their enhanced production of soluble TNF-R1 because inhibition of pKC activity with calphostin C caused soluble TNF-R1 production to decrease significantly.	calphostin C	154-166	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	182-188
14660552-4	2004	We show here that apoptosis is inhibited by the addition of exogenous phosphatidic acid, a metabolite of phospholipase D (PLD), and that calphostin-C inhibits completely the activities of both isoforms of PLD, PLD1 and PLD2.	calphostin C	137-149	LOW QUALITY PROTEIN: phospholipase D2	Cricetulus griseus	219-223
14534369-6	2003	A specific inhibitor for p38 mitogen-activated protein kinase, 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB 203580), and a protein kinase C inhibitor, calphostin C, had no inhibitory effects on TNF-alpha-induced PAI-1 secretion.	calphostin C	182-194	mitogen-activated protein kinase 1	Homo sapiens	25-28
14660621-4	2004	The mechanosensitivity of the GIRK4 current was abolished by pretreatment with PKC inhibitors (staurosporine or calphostin C).	calphostin C	112-124	potassium inwardly rectifying channel subfamily J member 5 L homeolog	Xenopus laevis	30-35
14719126-5	2004	The suppressive effect of beacon[47-73] on aldosterone secretion from ZG cells was abolished by either H-89 or calphostin-C, which are inhibitors of protein kinase A and C signaling cascades.	calphostin C	111-123	ubiquitin-like 5	Rattus norvegicus	26-32
15025824-8	2004	The migration rate and the associated changes in the electrical resistance, permeability to albumin, and ERK1/2 phosphorylation were all blocked by calphostin C, the specific blocker of PKC and by PD98059 (2"-amino-3"-methoxyflavone), a selective cell-permeable inhibitor of MAP kinase kinase.	calphostin C	148-160	mitogen-activated protein kinase 3	Homo sapiens	105-111
14636826-12	2003	Interestingly, inhibitors of phosphatidylinositol-3-kinase (PI-3-K), p38 and extracellular regulated kinase (ERK) activation significantly (p<0.05 vs. calphostin C only treatment) increased apoptosis when used in conjunction with calphostin C.	calphostin C	154-166	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	29-58
14636826-12	2003	Interestingly, inhibitors of phosphatidylinositol-3-kinase (PI-3-K), p38 and extracellular regulated kinase (ERK) activation significantly (p<0.05 vs. calphostin C only treatment) increased apoptosis when used in conjunction with calphostin C.	calphostin C	154-166	mitogen-activated protein kinase 1	Homo sapiens	77-107
14636826-12	2003	Interestingly, inhibitors of phosphatidylinositol-3-kinase (PI-3-K), p38 and extracellular regulated kinase (ERK) activation significantly (p<0.05 vs. calphostin C only treatment) increased apoptosis when used in conjunction with calphostin C.	calphostin C	154-166	mitogen-activated protein kinase 1	Homo sapiens	109-112
14765994-6	2004	In contrast, calcitonin induction but not basal expression was dependent on protein kinase A and protein kinase C (PKC) activities with the inhibitors H89 and calphostin C lowering induction by 50-60%.	calphostin C	159-171	proline rich transmembrane protein 2	Homo sapiens	97-113
14765994-6	2004	In contrast, calcitonin induction but not basal expression was dependent on protein kinase A and protein kinase C (PKC) activities with the inhibitors H89 and calphostin C lowering induction by 50-60%.	calphostin C	159-171	proline rich transmembrane protein 2	Homo sapiens	115-118
14600078-7	2003	PGF2alpha caused Ca2+-dependent alpha-PKC and Ca2+-independent epsilon-PKC translocation from cytosolic to particulate fractions that was inhibited by calphostin C.	calphostin C	151-163	carbonic anhydrase 2	Homo sapiens	17-20
14600078-7	2003	PGF2alpha caused Ca2+-dependent alpha-PKC and Ca2+-independent epsilon-PKC translocation from cytosolic to particulate fractions that was inhibited by calphostin C.	calphostin C	151-163	carbonic anhydrase 2	Homo sapiens	46-49
12947090-6	2003	Treatment of HepG2 cells with the PKC inhibitors staurosporine and calphostin C repressed ARE-mediated induction of a luciferase reporter as well as that of the endogenous NQO1 gene.	calphostin C	67-79	proline rich transmembrane protein 2	Homo sapiens	34-37
12947090-6	2003	Treatment of HepG2 cells with the PKC inhibitors staurosporine and calphostin C repressed ARE-mediated induction of a luciferase reporter as well as that of the endogenous NQO1 gene.	calphostin C	67-79	NAD(P)H quinone dehydrogenase 1	Homo sapiens	172-176
12967688-9	2003	The inhibitory effects of U69593 (kappa-opioid receptor agonist) and DAMGO (mu-opioid receptor agonist) on ACh overflow significantly increased in the presence of U73122, chelerythrine and calphostin C in preparations obtained from normal animals, but not in those obtained from sympathetically denervated animals.	calphostin C	189-201	mu-type opioid receptor	Cavia porcellus	76-94
12904331-5	2003	Co-administration of calphostin C (10 microM, a PKC inhibitor) and KN-93 (10 microM, a CaMKII inhibitor) completely blocked this Ang II action in WKY rat neurons, while they caused only a approximately 50% attenuation in SHR neurons.	calphostin C	21-33	angiotensinogen	Rattus norvegicus	129-135
14557253-5	2003	Consistent with this possibility, engagement of CD151 by the substrate-adsorbed anti-CD151 mAb induced prominent Cdc42-dependent filopodial extension, which along with E-cadherin puncta formation, was strongly inhibited by calphostin C, a protein kinase C (PKC) inhibitor.	calphostin C	223-235	CD151 molecule (Raph blood group)	Homo sapiens	48-53
14557253-5	2003	Consistent with this possibility, engagement of CD151 by the substrate-adsorbed anti-CD151 mAb induced prominent Cdc42-dependent filopodial extension, which along with E-cadherin puncta formation, was strongly inhibited by calphostin C, a protein kinase C (PKC) inhibitor.	calphostin C	223-235	CD151 molecule (Raph blood group)	Homo sapiens	85-90
14557253-5	2003	Consistent with this possibility, engagement of CD151 by the substrate-adsorbed anti-CD151 mAb induced prominent Cdc42-dependent filopodial extension, which along with E-cadherin puncta formation, was strongly inhibited by calphostin C, a protein kinase C (PKC) inhibitor.	calphostin C	223-235	cell division cycle 42	Homo sapiens	113-118
14557253-5	2003	Consistent with this possibility, engagement of CD151 by the substrate-adsorbed anti-CD151 mAb induced prominent Cdc42-dependent filopodial extension, which along with E-cadherin puncta formation, was strongly inhibited by calphostin C, a protein kinase C (PKC) inhibitor.	calphostin C	223-235	cadherin 1	Homo sapiens	168-178
14577610-7	2003	The involvement of PLD in pHi and [Ca2+]i changes was confirmed by calphostin-c treatment, a potent inhibitor of PLD, which abolished all AAPH-induced effects.	calphostin C	67-79	glucose-6-phosphate isomerase	Rattus norvegicus	26-29
12925217-10	2003	Histamine-induced enhancement of nerve growth factor secretion, promoter activity, activator protein 1 transcriptional activity, and c-Fos expression was suppressed by H1 antagonist pyrilamine, protein kinase C inhibitor calphostin C, and PD98059, an inhibitor of mitogen-activated protein kinase kinase 1.	calphostin C	221-233	nerve growth factor	Homo sapiens	33-52
12963813-7	2003	S1P1 induction by VEGF was attenuated by the tyrosine kinase inhibitor genistein and by the PKC inhibitor calphostin C.	calphostin C	106-118	sphingosine-1-phosphate receptor 1	Bos taurus	0-4
12963813-7	2003	S1P1 induction by VEGF was attenuated by the tyrosine kinase inhibitor genistein and by the PKC inhibitor calphostin C.	calphostin C	106-118	vascular endothelial growth factor A	Bos taurus	18-22
12943527-8	2003	Calphostin C and Go 6976, inhibitors of protein kinase C, reduced the ET-1-induced phosphorylation of SAPK/JNK.	calphostin C	0-12	endothelin 1	Mus musculus	70-74
12943527-8	2003	Calphostin C and Go 6976, inhibitors of protein kinase C, reduced the ET-1-induced phosphorylation of SAPK/JNK.	calphostin C	0-12	mitogen-activated protein kinase 8	Mus musculus	107-110
12925217-10	2003	Histamine-induced enhancement of nerve growth factor secretion, promoter activity, activator protein 1 transcriptional activity, and c-Fos expression was suppressed by H1 antagonist pyrilamine, protein kinase C inhibitor calphostin C, and PD98059, an inhibitor of mitogen-activated protein kinase kinase 1.	calphostin C	221-233	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	133-138
12887687-5	2003	The protein kinase C inhibitors, staurosporine and calphostin C, and the tyrosine kinase inhibitor genistein, but not its inactive analogue daidzein, prevented the induction of CYP2E1 by PDBu.	calphostin C	51-63	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	177-183
14513837-6	2003	Thrombin-inducedVEGF release was blocked by anti-thrombin, heparin, a synthetic thrombin receptor inhibitor E5510, the calcium chelator BAPTA, the protein kinase C inhibitor calphostin C, and the MEK1/2 inhibitor U0126.	calphostin C	174-186	coagulation factor II, thrombin	Homo sapiens	0-8
12967633-8	2003	TGFbeta1-induced expression of alpha-SM actin was inhibited in a dose-dependent manner by treating cells with a PKC inhibitor, calphostin C, and was abolished by depleting PKCalpha with antisense PKCalpha oligodeoxynucleotides.	calphostin C	127-139	transforming growth factor, beta 1	Rattus norvegicus	0-8
12967633-8	2003	TGFbeta1-induced expression of alpha-SM actin was inhibited in a dose-dependent manner by treating cells with a PKC inhibitor, calphostin C, and was abolished by depleting PKCalpha with antisense PKCalpha oligodeoxynucleotides.	calphostin C	127-139	protein kinase C, alpha	Rattus norvegicus	112-115
12941843-2	2003	Calphostin c [an inhibitor of classic and novel isoforms of protein kinase C (PKC)] sensitized five of six cell lines to TRAIL, whereas Go6976, (inhibitor of classic PKC isoforms), did not influence TRAIL sensitivity.	calphostin C	0-12	protein kinase C delta	Homo sapiens	78-81
12941843-2	2003	Calphostin c [an inhibitor of classic and novel isoforms of protein kinase C (PKC)] sensitized five of six cell lines to TRAIL, whereas Go6976, (inhibitor of classic PKC isoforms), did not influence TRAIL sensitivity.	calphostin C	0-12	TNF superfamily member 10	Homo sapiens	121-126
12693944-4	2003	The osteoblast-like cell line MG-63 was pretreated with calphostin C, a PKC inhibitor, or phorbol 12-myristate 13-acetate (PMA) for an extended period, a condition which causes PKC downregulation, and subsequently with AA.	calphostin C	56-68	protein kinase C alpha	Homo sapiens	177-180
12890576-4	2003	Phorbol myristicate ester (PMA), a protein kinase C (PKC) stimulator, increased the activity of NHE 1 whereas calphostin C, a PKC inhibitor, partially inhibited NHE 1 activation induced by adrenaline.	calphostin C	110-122	solute carrier family 9 member A1	Homo sapiens	161-166
12788225-3	2003	PMA-induced galectin-3 overexpression was blocked by: protein kinase C inhibitors staurosporine, calphostin C, and apigenin; tyrosine-specific protein kinase inhibitors genistein and tyrphostin A25; PD 98059, a selective inhibitor of mitogen-activated protein kinase (MAPK) kinase 1 (MEK1 or MKK1); and SB 203580, a specific inhibitor of p38 MAPK.	calphostin C	97-109	galectin 3	Homo sapiens	12-22
12714566-10	2003	Calphostin C, a general PKC inhibitor, blocked both C pneumoniae-induced ICAM-1 expression and C pneumoniae-induced NF-kappaB translocation.	calphostin C	0-12	intercellular adhesion molecule 1	Homo sapiens	73-79
12794177-6	2003	The contraction-induced activation of HSL was abolished by the protein kinase C (PKC) inhibitors bisindolylmaleimide I and calphostin C and reduced 50% by the mitogen-activated protein kinase kinase (MEK) inhibitor U0126, which also completely blocked extracellular signal-regulated kinase (ERK) 1 and 2 phosphorylation.	calphostin C	123-135	lipase E, hormone sensitive type	Rattus norvegicus	38-41
12724308-4	2003	Selective inhibitors of PKC such as GF109203X and Calphostin C both caused approximately 80% inhibition of chemotaxis.	calphostin C	50-62	protein kinase C alpha	Homo sapiens	24-27
12759177-6	2003	Three PKC inhibitors (staurosporine, calphostin C, and chelerythrine) did not affect basal EAAT3 activity but significantly inhibited the propofol-enhanced EAAT3 activity.	calphostin C	37-49	solute carrier family 1 member 1	Rattus norvegicus	156-161
12940464-5	2003	GnRH-induced LH secretion was completely inhibited by calphostin C (a protein kinase C inhibitor) and 1 microM wortmannin.	calphostin C	54-66	gonadotropin releasing hormone 1	Mus musculus	0-4
12551901-9	2003	In our studies, opioid-mediated down-regulation of MIP-1 alpha receptors could be blocked by the general PKC inhibitor calphostin C, but not by the calcium-dependent classic PKC inhibitor Go6976.	calphostin C	119-131	C-C motif chemokine ligand 3	Homo sapiens	51-62
12646172-1	2003	Our discovery of rapid down-regulation of human bilirubin UDP-glucuronosyltransferase (UGT) in colon cell lines that was transient and irreversible following curcumin- and calphostin-C-treatment, respectively, suggested phosphorylation event(s) were involved in activity.	calphostin C	172-184	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	58-85
12646172-1	2003	Our discovery of rapid down-regulation of human bilirubin UDP-glucuronosyltransferase (UGT) in colon cell lines that was transient and irreversible following curcumin- and calphostin-C-treatment, respectively, suggested phosphorylation event(s) were involved in activity.	calphostin C	172-184	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	87-90
12646172-2	2003	Likewise, bilirubin-UGT1A1 expressed in COS-1 cells was inhibited by curcumin and calphostin-C.	calphostin C	82-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-26
12581868-8	2003	Chronic exposure to the protein kinase C inhibitors bisindolylmaleimide and calphostin C blocked increased production of both fibronectin and collagen XII from cells under tension.	calphostin C	76-88	fibronectin 1	Homo sapiens	126-137
12631113-9	2003	The incubation of MCs with calphostin C [a selective inhibitor of protein kinase C (PKC)] or PD98059 [a selective inhibitor of p42/44 mitogen-activated protein kinase (MAPK) kinase] attenuated TNF-alpha-stimulated fractalkine mRNA and protein expression.	calphostin C	27-39	protein kinase C zeta	Homo sapiens	84-87
12586359-7	2003	The tyrosine kinase (TK) inhibitor tyrphostin-23 and the p42/p44 mitogen-activated protein kinase (MAPK) inhibitor PD-98059 abolished the proliferogenic effect of 10(-8) M ghrelin, while the protein kinase A and C inhibitors H-89 and calphostin-C were ineffective.	calphostin C	234-246	mitogen activated protein kinase 3	Rattus norvegicus	61-64
12586359-7	2003	The tyrosine kinase (TK) inhibitor tyrphostin-23 and the p42/p44 mitogen-activated protein kinase (MAPK) inhibitor PD-98059 abolished the proliferogenic effect of 10(-8) M ghrelin, while the protein kinase A and C inhibitors H-89 and calphostin-C were ineffective.	calphostin C	234-246	mitogen activated protein kinase 3	Rattus norvegicus	99-103
12586359-7	2003	The tyrosine kinase (TK) inhibitor tyrphostin-23 and the p42/p44 mitogen-activated protein kinase (MAPK) inhibitor PD-98059 abolished the proliferogenic effect of 10(-8) M ghrelin, while the protein kinase A and C inhibitors H-89 and calphostin-C were ineffective.	calphostin C	234-246	ghrelin and obestatin prepropeptide	Rattus norvegicus	172-179
12551748-4	2003	The cell death was suppressed by a protein kinase C (PKC) activator, 12,13-phorbol myristate acetate, but was enhanced by PKC specific inhibitor calphostin C or bisindolylmaleimide, not by PKC inhibitor relatively specific for PKC-alpha (safingol) or PKC-delta (rottlerin).	calphostin C	145-157	protein kinase C, gamma	Rattus norvegicus	122-125
12551748-4	2003	The cell death was suppressed by a protein kinase C (PKC) activator, 12,13-phorbol myristate acetate, but was enhanced by PKC specific inhibitor calphostin C or bisindolylmaleimide, not by PKC inhibitor relatively specific for PKC-alpha (safingol) or PKC-delta (rottlerin).	calphostin C	145-157	protein kinase C, gamma	Rattus norvegicus	122-125
12631113-9	2003	The incubation of MCs with calphostin C [a selective inhibitor of protein kinase C (PKC)] or PD98059 [a selective inhibitor of p42/44 mitogen-activated protein kinase (MAPK) kinase] attenuated TNF-alpha-stimulated fractalkine mRNA and protein expression.	calphostin C	27-39	tumor necrosis factor	Homo sapiens	193-202
12631113-9	2003	The incubation of MCs with calphostin C [a selective inhibitor of protein kinase C (PKC)] or PD98059 [a selective inhibitor of p42/44 mitogen-activated protein kinase (MAPK) kinase] attenuated TNF-alpha-stimulated fractalkine mRNA and protein expression.	calphostin C	27-39	C-X3-C motif chemokine ligand 1	Homo sapiens	214-225
12631113-10	2003	Coincubation of MCs with calphostin C and PD98059 resulted in a synergistic inhibition of TNF-alpha-stimulated fractalkine mRNA and protein expression.	calphostin C	25-37	tumor necrosis factor	Homo sapiens	90-99
12631113-10	2003	Coincubation of MCs with calphostin C and PD98059 resulted in a synergistic inhibition of TNF-alpha-stimulated fractalkine mRNA and protein expression.	calphostin C	25-37	C-X3-C motif chemokine ligand 1	Homo sapiens	111-122
12631113-11	2003	Incubation of MCs with phorbol myristate acetate (PMA) for four hours resulted in an increase in fractalkine mRNA expression that could be suppressed by calphostin C or depletion of PKC by pretreatment with PMA for 24 hours.	calphostin C	153-165	C-X3-C motif chemokine ligand 1	Homo sapiens	97-108
12813560-0	2003	Syndecan-4 distribution during the differentiation of satellite cells isolated from soleus muscle treated by phorbol ester and calphostin C.	calphostin C	127-139	syndecan 4	Homo sapiens	0-10
12813560-9	2003	We used the PKC activator TPA (12-O-tetradecanoyl phorbol 13-acetate) and the PKC inhibitor Calphostin C (Cal C).	calphostin C	92-104	mitochondrial calcium uptake 1	Homo sapiens	106-111
12573708-11	2003	In addition, the rise in transepithelial electrical resistance induced by eicosapentaenoic acids and gamma linolenic acid was markedly inhibited by the tyrosine kinase inhibitors genistein and PP2 and protein kinase C inhibitor, calphostin C.	calphostin C	229-241	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	193-196
12414091-6	2002	The inhibition of MBP expression by 100 mM EtOH or 1 nM PMA was completely counteracted by three inhibitors of protein kinase C (PKC), bisindolylmaleimide I, chelerythrine chloride, and calphostin C, indicating that EtOH downregulated MBP expression by activating PKC.	calphostin C	186-198	myelin basic protein	Rattus norvegicus	18-21
12368297-8	2002	Whereas the protein kinase C (PKC) inhibitor (calphostin C) pretreatment was shown to inhibit strain-induced NADPH oxidase activity, ECs treated with either calphostin C or the inhibitor to NADPH oxidase (DPI) reduced strain-induced ROS levels and then greatly inhibited the Src and PYK2 activation.	calphostin C	46-58	protein kinase C alpha	Bos taurus	30-33
12368297-8	2002	Whereas the protein kinase C (PKC) inhibitor (calphostin C) pretreatment was shown to inhibit strain-induced NADPH oxidase activity, ECs treated with either calphostin C or the inhibitor to NADPH oxidase (DPI) reduced strain-induced ROS levels and then greatly inhibited the Src and PYK2 activation.	calphostin C	46-58	SRC proto-oncogene, non-receptor tyrosine kinase	Bos taurus	275-278
12368297-8	2002	Whereas the protein kinase C (PKC) inhibitor (calphostin C) pretreatment was shown to inhibit strain-induced NADPH oxidase activity, ECs treated with either calphostin C or the inhibitor to NADPH oxidase (DPI) reduced strain-induced ROS levels and then greatly inhibited the Src and PYK2 activation.	calphostin C	46-58	protein tyrosine kinase 2 beta	Bos taurus	283-287
12368297-8	2002	Whereas the protein kinase C (PKC) inhibitor (calphostin C) pretreatment was shown to inhibit strain-induced NADPH oxidase activity, ECs treated with either calphostin C or the inhibitor to NADPH oxidase (DPI) reduced strain-induced ROS levels and then greatly inhibited the Src and PYK2 activation.	calphostin C	157-169	protein kinase C alpha	Bos taurus	30-33
12456804-6	2002	Multiple nonselective PKC inhibitors, including staurosporine, bisindolylmaleimide I, and Calphostin C, inhibited both EGF and TRH induced rat PRL promoter activity.	calphostin C	90-102	protein kinase C, alpha	Rattus norvegicus	22-25
12456804-6	2002	Multiple nonselective PKC inhibitors, including staurosporine, bisindolylmaleimide I, and Calphostin C, inhibited both EGF and TRH induced rat PRL promoter activity.	calphostin C	90-102	epidermal growth factor like 1	Rattus norvegicus	119-122
12456804-6	2002	Multiple nonselective PKC inhibitors, including staurosporine, bisindolylmaleimide I, and Calphostin C, inhibited both EGF and TRH induced rat PRL promoter activity.	calphostin C	90-102	thyrotropin releasing hormone	Rattus norvegicus	127-130
12456804-6	2002	Multiple nonselective PKC inhibitors, including staurosporine, bisindolylmaleimide I, and Calphostin C, inhibited both EGF and TRH induced rat PRL promoter activity.	calphostin C	90-102	prolactin	Rattus norvegicus	143-146
12456804-7	2002	TRH effects were more sensitive to Calphostin C, a competitive inhibitor of diacylglycerol, whereas Go 6976, a selective inhibitor of Ca(2+)-dependent PKCs, produced a modest inhibition of EGF but no inhibition of TRH effects.	calphostin C	35-47	thyrotropin releasing hormone	Rattus norvegicus	0-3
12444598-6	2002	The effects of neurotensin were counteracted by the neurotensin receptor antagonist SR48692 (100 nM) and by the protein kinase C inhibitor calphostin C.	calphostin C	139-151	neurotensin	Rattus norvegicus	15-26
12213812-8	2002	Similarly, calphostin C and rottlerin depressed activation of p44/42 MAPK.	calphostin C	11-23	mitogen activated protein kinase 3	Rattus norvegicus	62-65
12213812-8	2002	Similarly, calphostin C and rottlerin depressed activation of p44/42 MAPK.	calphostin C	11-23	mitogen activated protein kinase 3	Rattus norvegicus	69-73
12213812-6	2002	The PKC-specific inhibitors bisindolylmaleimide I, calphostin C, CGP 41251, and the PKCdelta-selective inhibitor rottlerin were able to suppress serotonin up-regulation of MMP-13.	calphostin C	51-63	matrix metallopeptidase 13	Rattus norvegicus	172-178
12384249-10	2002	The fall in TEER from bradykinin was blocked by HOE 140, U73122 and thapsigargin combined with La(3+), and also by aristolochic acid and NDGA, but not indomethacin, calphostin C or L-NAME.	calphostin C	165-177	kininogen 1	Homo sapiens	22-32
12453054-7	2002	Incubation of melanotrophs with the diacylglycerol analogue PMA, which causes desensitization of protein kinase C (PKC), or with the PKC inhibitors chelerythrine and calphostin C, reduced the inhibitory effect of f NT.	calphostin C	166-178	neurotensin	Homo sapiens	215-217
12196513-5	2002	The up-regulation of Rap1b mRNA was mitigated by the PKC inhibitors, calphostin C, and bisindolymaleimide, while also reducing HG- induced FN expression in non-transfected MCs.	calphostin C	69-81	RAP1B, member of RAS oncogene family	Rattus norvegicus	21-26
12384259-9	2002	This inhibition was reversed by staurosporine and calphostin C, two protein kinase C (PKC) inhibitors, but not by the third PKC inhibitor, chelerythrine.	calphostin C	50-62	protein kinase C, gamma	Rattus norvegicus	68-84
12384259-9	2002	This inhibition was reversed by staurosporine and calphostin C, two protein kinase C (PKC) inhibitors, but not by the third PKC inhibitor, chelerythrine.	calphostin C	50-62	protein kinase C, gamma	Rattus norvegicus	86-89
12323385-6	2002	However, pretreatment with the selective PKC inhibitor, calphostin-C significantly antagonized the corticosterone hypersecretion in morphine-withdrawn rats.	calphostin C	56-68	protein kinase C, gamma	Rattus norvegicus	41-44
12369848-8	2002	Inhibition of PKC with either calphostin C, a blocker of the PMA binding site, or chelerythrine chloride, an inhibitor of the active site, diminished the level of formation of PS-exposing cells.	calphostin C	30-42	proline rich transmembrane protein 2	Homo sapiens	14-17
12368220-8	2002	This overexpression was inhibited by pretreatment with calphostin C, an inhibitor of protein kinase C. These findings suggest that LPS can induce overexpression of MUC2 and MUC5AC in biliary epithelial cells via synthesis of TNF-alpha and activation of protein kinase C. This mechanism might be involved in the lithogenesis of hepatolithiasis.	calphostin C	55-67	mucin 2	Mus musculus	164-168
12368220-8	2002	This overexpression was inhibited by pretreatment with calphostin C, an inhibitor of protein kinase C. These findings suggest that LPS can induce overexpression of MUC2 and MUC5AC in biliary epithelial cells via synthesis of TNF-alpha and activation of protein kinase C. This mechanism might be involved in the lithogenesis of hepatolithiasis.	calphostin C	55-67	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	173-179
12368220-8	2002	This overexpression was inhibited by pretreatment with calphostin C, an inhibitor of protein kinase C. These findings suggest that LPS can induce overexpression of MUC2 and MUC5AC in biliary epithelial cells via synthesis of TNF-alpha and activation of protein kinase C. This mechanism might be involved in the lithogenesis of hepatolithiasis.	calphostin C	55-67	tumor necrosis factor	Mus musculus	225-234
12077118-4	2002	Protein kinase C inhibitors (bisindolylmaleimide, calphostin C) and inhibitors of mitogen-activated protein/extracellular signal regulated kinase kinase (MEK) (PD98059 and U0126) suppressed up-regulation of MUC2.	calphostin C	50-62	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	207-211
12231451-6	2002	The effects of phorbol esters were antagonized by the specific PKC blockers bisindolylmaleimide and calphostin C.	calphostin C	100-112	Prkca	Cavia porcellus	63-66
12070216-4	2002	This increase in PKC is observed with 15 min of HDE treatment, and kinase activity reaches peak activity by 1-2 h of HDE treatment before returning to baseline PKC levels between 6 and 24 h. The classic PKC inhibitor, calphostin C, blocks HDE-stimulated PKC activity and associated IL-8 and IL-6 release.	calphostin C	218-230	C-X-C motif chemokine ligand 8	Homo sapiens	282-286
12355490-9	2002	Calphostin C, a specific inhibitor of protein kinase C (PKC), inhibited TGF(beta)RI promoter activity in SSc fibroblasts, and LY294002, an inhibitor of phosphoinositide 3-kinase (PI 3-kinase), inhibited TGF(beta)RII promoter activity in SSc fibroblasts.	calphostin C	0-12	transforming growth factor beta receptor 1	Homo sapiens	72-83
12355490-10	2002	Moreover, calphostin C and LY294002 inhibited the up-regulation of TGF(beta)RI and TGF(beta)RII mRNA, respectively, in SSc fibroblasts.	calphostin C	10-22	transforming growth factor beta receptor 1	Homo sapiens	67-78
12355490-10	2002	Moreover, calphostin C and LY294002 inhibited the up-regulation of TGF(beta)RI and TGF(beta)RII mRNA, respectively, in SSc fibroblasts.	calphostin C	10-22	transforming growth factor beta receptor 2	Homo sapiens	83-95
12164862-3	2002	RESULTS: TGF-beta up-regulated FN mRNA accumulation in a time- and dose-dependent manner, which was completely inhibited by phosphatidylcholine-phospholipase C (PC-PLC) inhibitor and PKC inhibitors (calphostin-C and staurosporin).	calphostin C	199-211	transforming growth factor beta 1	Homo sapiens	9-17
12164862-3	2002	RESULTS: TGF-beta up-regulated FN mRNA accumulation in a time- and dose-dependent manner, which was completely inhibited by phosphatidylcholine-phospholipase C (PC-PLC) inhibitor and PKC inhibitors (calphostin-C and staurosporin).	calphostin C	199-211	fibronectin 1	Homo sapiens	31-33
12164862-7	2002	In mesangial cells stably transfected with a chimera containing HB-EGF and alkaline phosphatase (ALP) genes, ALP activity in incubation medium was rapidly increased by TGF-beta (2.1-fold at 0.5 min) and reached a 3.7-fold increase at two minutes, which was abolished by calphostin-C or batimastat.	calphostin C	270-282	heparin binding EGF like growth factor	Homo sapiens	64-70
12164862-7	2002	In mesangial cells stably transfected with a chimera containing HB-EGF and alkaline phosphatase (ALP) genes, ALP activity in incubation medium was rapidly increased by TGF-beta (2.1-fold at 0.5 min) and reached a 3.7-fold increase at two minutes, which was abolished by calphostin-C or batimastat.	calphostin C	270-282	alkaline phosphatase, placental	Homo sapiens	75-95
12164862-7	2002	In mesangial cells stably transfected with a chimera containing HB-EGF and alkaline phosphatase (ALP) genes, ALP activity in incubation medium was rapidly increased by TGF-beta (2.1-fold at 0.5 min) and reached a 3.7-fold increase at two minutes, which was abolished by calphostin-C or batimastat.	calphostin C	270-282	alkaline phosphatase, placental	Homo sapiens	97-100
12164862-7	2002	In mesangial cells stably transfected with a chimera containing HB-EGF and alkaline phosphatase (ALP) genes, ALP activity in incubation medium was rapidly increased by TGF-beta (2.1-fold at 0.5 min) and reached a 3.7-fold increase at two minutes, which was abolished by calphostin-C or batimastat.	calphostin C	270-282	alkaline phosphatase, placental	Homo sapiens	109-112
12164862-7	2002	In mesangial cells stably transfected with a chimera containing HB-EGF and alkaline phosphatase (ALP) genes, ALP activity in incubation medium was rapidly increased by TGF-beta (2.1-fold at 0.5 min) and reached a 3.7-fold increase at two minutes, which was abolished by calphostin-C or batimastat.	calphostin C	270-282	transforming growth factor beta 1	Homo sapiens	168-176
12147293-6	2002	Immunoblotting of the cytosolic fraction of rat tail arteries stimulated with ET-1 or NA showed an increase in extracellular signal-regulated kinases (ERKs) phosphorylation and this effect was abolished by calphostin C treatment.	calphostin C	206-218	endothelin 1	Rattus norvegicus	78-82
12070216-4	2002	This increase in PKC is observed with 15 min of HDE treatment, and kinase activity reaches peak activity by 1-2 h of HDE treatment before returning to baseline PKC levels between 6 and 24 h. The classic PKC inhibitor, calphostin C, blocks HDE-stimulated PKC activity and associated IL-8 and IL-6 release.	calphostin C	218-230	interleukin 6	Homo sapiens	291-295
11880362-8	2002	In addition, diacylglycerol, a physiological PKC agonist, induced a significant increase in hMSH2 expression, whereas chelerythrine or calphostin C, two PKC inhibitors, significantly decreased TPA-induced hMSH2 expression.	calphostin C	135-147	mutS homolog 2	Homo sapiens	205-210
12056817-5	2002	The results showed that a MEK1 inhibitor, PD98059, a p38MAPK inhibitor, SB202190, and a protein kinase C (PKC) inhibitor, Calphostin C, markedly decreased the IL-8 secretion from SK-N-MC (RET) cells at 24 h after GDNF stimulation.	calphostin C	122-134	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12126787-7	2002	The AGE-induced increases in VEGF expression and PKC activation were inhibited by the pan-specific PKC inhibitor, calphostin C, and by the antioxidant drug and compounds, gliclazide, N-acetylcysteine, and vitamin E.	calphostin C	114-126	vascular endothelial growth factor A	Bos taurus	29-33
12067896-4	2002	Because conventional inhibitors of PKC, such as staurosporine or calphostin C, also inhibit a variety of other protein kinases, we used a novel compound to specifically inhibit PKC.	calphostin C	65-77	proline rich transmembrane protein 2	Homo sapiens	177-180
11882608-6	2002	The Ang II-induced increase in firing rate was abolished by inhibition of phospholipase C with U73122 (10 micromol/L), and was attenuated by the protein kinase C inhibitor calphostin C (10 micromol/L) or by the calcium/calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 (10 micromol/L).	calphostin C	172-184	angiotensinogen	Rattus norvegicus	4-10
11960785-3	2002	C2-ceramide (0.1 microM), an activator of protein kinase C (PKC), induced a sustained increase in HSP27 phosphorylation that was inhibited by calphostin C.	calphostin C	142-154	heat shock protein family B (small) member 1	Homo sapiens	98-103
11934810-10	2002	The effect of NPY on 4-AP I(to) density was prevented by pretreatment with 500 ng ml(-1) pertussis toxin (PTX) and by the specific protein kinase C (PKC) inhibitor, calphostin C (100 nM).	calphostin C	165-177	neuropeptide Y	Rattus norvegicus	14-17
11989977-9	2002	Calphostin C, a PKC inhibitor, suppressed pervanadate-induced p38 MAPK and PLD activation in a dose-dependent manner.	calphostin C	0-12	mitogen-activated protein kinase 14	Homo sapiens	62-65
11966773-9	2002	The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect.	calphostin C	57-69	interleukin 17A	Homo sapiens	128-133
11966773-9	2002	The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect.	calphostin C	57-69	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
11966773-9	2002	The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect.	calphostin C	57-69	C-X-C motif chemokine ligand 1	Homo sapiens	170-179
11966773-9	2002	The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect.	calphostin C	57-69	C-X-C motif chemokine ligand 2	Homo sapiens	184-192
11966773-9	2002	The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect.	calphostin C	57-69	mitogen-activated protein kinase kinase 1	Homo sapiens	231-238
11994364-5	2002	Basal and Ca(o)(2+)-stimulated ERK1 and -2 activity was nearly abolished by the PKC inhibitor calphostin C, and PKA changes did not affect ERK1 and -2 activity.	calphostin C	94-106	mitogen-activated protein kinase 3	Homo sapiens	31-42
11836007-5	2002	The phosphatidylinositol 3-kinase inhibitor wortmannin, the calmodulin inhibitor W-7 and the protein kinase (PK) C inhibitor calphostin-C significantly blunted the secretory responses ensuing from the activation of both receptor subtypes.	calphostin C	125-137	proline rich transmembrane protein 2	Homo sapiens	93-114
11882608-7	2002	A combination of calphostin C and KN-93 completely inhibited this Ang II action.	calphostin C	17-29	angiotensinogen	Rattus norvegicus	66-72
11779197-3	2002	Agents that activate Ca(2+)-dependent PKC [phorbol-12-myristate-13-acetate (PMA) and bryostatin 1] increased the level of ER cholesterol; inhibitors such as staurosporine and calphostin C decreased it.	calphostin C	175-187	protein kinase C delta	Homo sapiens	38-41
11813828-6	2002	Preincubation with the PKC inhibitor calphostin C (1 microM) significantly suppressed IL-8 release in HBEC treated with CSE and C5a.	calphostin C	37-49	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
11739114-5	2002	The PMA- and the P-gp inhibitors-induced RVI was abolished by cotreatment with the PKC inhibitors (staurosporine or calphostin C).	calphostin C	116-128	phosphoglycolate phosphatase	Mus musculus	17-21
12377207-3	2002	The PKC inhibitors GF109203X and calphostin C inhibited VEGF-induced Akt activation.	calphostin C	33-45	protein kinase C delta	Homo sapiens	4-7
12377207-3	2002	The PKC inhibitors GF109203X and calphostin C inhibited VEGF-induced Akt activation.	calphostin C	33-45	vascular endothelial growth factor A	Homo sapiens	56-60
12377207-3	2002	The PKC inhibitors GF109203X and calphostin C inhibited VEGF-induced Akt activation.	calphostin C	33-45	AKT serine/threonine kinase 1	Homo sapiens	69-72
12210750-2	2002	The aim of the present study was to investigate the effect of PKA and PKC activities on the distribution of perilipin and ADRP in primary cultured adrenal cells, and the role of ERK in PMA- and calphostin C-induced steroidogenesis.	calphostin C	194-206	Eph receptor B1	Rattus norvegicus	178-181
11813828-6	2002	Preincubation with the PKC inhibitor calphostin C (1 microM) significantly suppressed IL-8 release in HBEC treated with CSE and C5a.	calphostin C	37-49	complement C5a receptor 1	Homo sapiens	128-131
11606596-6	2001	The enzyme that mediated the formation of this stable core protein dimer was determined to be the tissue transglutaminase (tTG) because, first, tTG could be activated by calphostin C and serum deprivation; second, the formation of this dimer was suppressed by monodansylcadaverine, a tTG inhibitor; and third, the core protein could be cross-linked by tTG in vitro.	calphostin C	170-182	transglutaminase 2	Homo sapiens	98-121
11606596-6	2001	The enzyme that mediated the formation of this stable core protein dimer was determined to be the tissue transglutaminase (tTG) because, first, tTG could be activated by calphostin C and serum deprivation; second, the formation of this dimer was suppressed by monodansylcadaverine, a tTG inhibitor; and third, the core protein could be cross-linked by tTG in vitro.	calphostin C	170-182	transglutaminase 2	Homo sapiens	123-126
11606596-6	2001	The enzyme that mediated the formation of this stable core protein dimer was determined to be the tissue transglutaminase (tTG) because, first, tTG could be activated by calphostin C and serum deprivation; second, the formation of this dimer was suppressed by monodansylcadaverine, a tTG inhibitor; and third, the core protein could be cross-linked by tTG in vitro.	calphostin C	170-182	transglutaminase 2	Homo sapiens	144-147
11606596-6	2001	The enzyme that mediated the formation of this stable core protein dimer was determined to be the tissue transglutaminase (tTG) because, first, tTG could be activated by calphostin C and serum deprivation; second, the formation of this dimer was suppressed by monodansylcadaverine, a tTG inhibitor; and third, the core protein could be cross-linked by tTG in vitro.	calphostin C	170-182	transglutaminase 2	Homo sapiens	144-147
11606596-6	2001	The enzyme that mediated the formation of this stable core protein dimer was determined to be the tissue transglutaminase (tTG) because, first, tTG could be activated by calphostin C and serum deprivation; second, the formation of this dimer was suppressed by monodansylcadaverine, a tTG inhibitor; and third, the core protein could be cross-linked by tTG in vitro.	calphostin C	170-182	transglutaminase 2	Homo sapiens	144-147
11562372-6	2001	Ouabain-induced activation of ERK1/2 was blocked by PKC inhibitors calphostin C and chelerythrine.	calphostin C	67-79	mitogen activated protein kinase 3	Rattus norvegicus	30-36
11701232-3	2001	Inhibition of protein kinase C (PKC) activity using bisindolylmaleimide or calphostin C abolished the increased PPARalpha expression by the peroxisome proliferators whereas the expression of the ACOX gene remained unaffected.	calphostin C	75-87	peroxisome proliferator activated receptor alpha	Rattus norvegicus	112-121
11724747-9	2001	The histamine-induced increase in the content of VEGF protein in the conditioned medium was inhibited by the cyclic AMP antagonist Rp-cAMP (IC(50) 6.8 microM), and the protein kinase A inhibitor H-89 (IC(50) 12.5 microM), but not by the protein kinase C inhibitors Ro 31-8425 and calphostin C or the tyrosine kinase inhibitor genistein.	calphostin C	280-292	vascular endothelial growth factor A	Rattus norvegicus	49-53
11839459-6	2001	Protein kinase C activation and IL-8 release were blocked by pretreating BECs with 1 microM calphostin C or 100 nM of the PKC alpha-specific inhibitor, Go 6976.	calphostin C	92-104	C-X-C motif chemokine ligand 8	Bos taurus	32-36
11834445-5	2002	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), suppressed the PGE2-induced HSP27 accumulation.	calphostin C	18-30	heat shock protein 1	Mus musculus	98-103
11708841-5	2001	In contrast, protein kinase C (PKC) inhibitors, chelerythrine (20 microm) and calphostin C (1 microm) completely inhibited both, the angiotensin II-induced increase in L-type calcium current and positive inotropic effect.	calphostin C	78-90	angiotensinogen	Homo sapiens	133-147
11747626-6	2001	In human osteoblasts (SaM-1 cells) treated with 10 microg/ml LPS, increases in IL-6 mRNA and synthesis were inhibited by anti-CD14 antibody (MEM-18), PD98059 (an inhibitor of classic mitogen-activated protein kinase [MAPK]), or SB203580 (an inhibitor of p38 MAPK) but were not inhibited by H-89 (an inhibitor of protein kinase A [PKA]) and calphostin C (an inhibitor of protein kinase C [PKC]).	calphostin C	340-352	interleukin 6	Homo sapiens	79-83
11747626-6	2001	In human osteoblasts (SaM-1 cells) treated with 10 microg/ml LPS, increases in IL-6 mRNA and synthesis were inhibited by anti-CD14 antibody (MEM-18), PD98059 (an inhibitor of classic mitogen-activated protein kinase [MAPK]), or SB203580 (an inhibitor of p38 MAPK) but were not inhibited by H-89 (an inhibitor of protein kinase A [PKA]) and calphostin C (an inhibitor of protein kinase C [PKC]).	calphostin C	340-352	CD14 molecule	Homo sapiens	126-130
11435215-4	2001	The protein kinase C inhibitors staurosporine (10(-8) mol/l) and calphostin C (10(-7) mol/l) abolished the induction of ET-1 gene expression by CSE in bovine and human PAECs.	calphostin C	65-77	endothelin 1	Bos taurus	120-124
11574422-3	2001	HG (30 mmol/l for 72 h) enhanced ET-1-stimulated alpha1(IV) collagen mRNA expression from 1.2 +/- 0.1-fold to 1.9 +/- 0.2-fold (P < 0.05 vs. normal glucose [NG] + ET-1), and the effect was significantly reduced by Calphostin C or the MEK (mitogen-activated protein kinase kinase) inhibitor PD98059.	calphostin C	217-229	endothelin 1	Homo sapiens	33-37
11595754-7	2001	Amitriptyline-induced GDNF release was inhibited by U0126 (10 microM), a mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (1 microM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 microM), a p38 mitogen-activated protein kinase inhibitor.	calphostin C	251-263	glial cell derived neurotrophic factor	Rattus norvegicus	22-26
11473356-7	2001	Addition of calphostin C, a protein kinase C (PKC) inhibitor, completely blocked the hypoxia-augmented Egr-1 expression.	calphostin C	12-24	protein kinase C alpha	Bos taurus	46-49
11473356-7	2001	Addition of calphostin C, a protein kinase C (PKC) inhibitor, completely blocked the hypoxia-augmented Egr-1 expression.	calphostin C	12-24	early growth response 1	Bos taurus	103-108
11395480-9	2001	The proapoptotic effect of BMP-2 is PKC-dependent, because BMP-2 increases PKC activity, and the selective PKC inhibitor calphostin C blocks the BMP-2-induced increased Bax/Bcl-2, caspase activity, and apoptosis.	calphostin C	121-133	bone morphogenetic protein 2	Homo sapiens	27-32
11395480-9	2001	The proapoptotic effect of BMP-2 is PKC-dependent, because BMP-2 increases PKC activity, and the selective PKC inhibitor calphostin C blocks the BMP-2-induced increased Bax/Bcl-2, caspase activity, and apoptosis.	calphostin C	121-133	BCL2 associated X, apoptosis regulator	Homo sapiens	169-172
11395480-9	2001	The proapoptotic effect of BMP-2 is PKC-dependent, because BMP-2 increases PKC activity, and the selective PKC inhibitor calphostin C blocks the BMP-2-induced increased Bax/Bcl-2, caspase activity, and apoptosis.	calphostin C	121-133	BCL2 apoptosis regulator	Homo sapiens	173-178
11395480-9	2001	The proapoptotic effect of BMP-2 is PKC-dependent, because BMP-2 increases PKC activity, and the selective PKC inhibitor calphostin C blocks the BMP-2-induced increased Bax/Bcl-2, caspase activity, and apoptosis.	calphostin C	121-133	caspase 6	Homo sapiens	180-187
11399752-9	2001	ECs under cyclic strain induced a sustained activation of extracellular signal-regulated protein kinases (ERK1/2), which was inhibited by treating ECs with calphostin C.	calphostin C	156-168	mitogen-activated protein kinase 3	Homo sapiens	106-112
11483406-6	2001	The PGD(2)-stimulated accumulation of HSP27 was reduced by staurosporine or calphostin C, inhibitors of PKC.	calphostin C	76-88	heat shock protein 1	Mus musculus	38-43
11483411-5	2001	The amount of VEGF protein in conditioned media was increased by PMA in a dose-dependent manner with a maximal effect at 10(-7) M. Staurosporine and calphostin C (PKC inhibitors) decreased PMA-induced VEGF mRNA expression as opposed to protein kinase A or cyclic nucleotide-dependent protein kinase inhibitors.	calphostin C	149-161	vascular endothelial growth factor A	Homo sapiens	14-18
11483407-11	2001	NF-kappaB DNA-protein binding and ICAM-1 promoter activity were enhanced by TNF-alpha and these effects were inhibited by D 609, calphostin C, or tyrphostin 23, but not by PD 98059 or SB 203580.	calphostin C	129-141	intercellular adhesion molecule 1	Homo sapiens	34-40
11416005-7	2001	The greater increase in amplitude of the L channel current by PACAP in VSMC from SHR persisted in the presence of adenosine cyclic 3",5"-monophosphothioate, Rp-isomer, a cAMP antagonist, but not calphostin C, a PKC inhibitor.	calphostin C	195-207	adenylate cyclase activating polypeptide 1	Rattus norvegicus	62-67
11483407-11	2001	NF-kappaB DNA-protein binding and ICAM-1 promoter activity were enhanced by TNF-alpha and these effects were inhibited by D 609, calphostin C, or tyrphostin 23, but not by PD 98059 or SB 203580.	calphostin C	129-141	tumor necrosis factor	Homo sapiens	76-85
11485390-9	2001	Cotreatment of H4IIEC3 cells with CA and the antioxidant N-acetylcysteine or calphostin C, a specific inhibitor of protein kinase C (PKC), blocked the AP-1 activation and the expression of the AP-1-driven luciferase reporter gene.	calphostin C	77-89	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	151-155
11485390-9	2001	Cotreatment of H4IIEC3 cells with CA and the antioxidant N-acetylcysteine or calphostin C, a specific inhibitor of protein kinase C (PKC), blocked the AP-1 activation and the expression of the AP-1-driven luciferase reporter gene.	calphostin C	77-89	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	193-197
11483411-5	2001	The amount of VEGF protein in conditioned media was increased by PMA in a dose-dependent manner with a maximal effect at 10(-7) M. Staurosporine and calphostin C (PKC inhibitors) decreased PMA-induced VEGF mRNA expression as opposed to protein kinase A or cyclic nucleotide-dependent protein kinase inhibitors.	calphostin C	149-161	vascular endothelial growth factor A	Homo sapiens	201-205
11457819-10	2001	Calphostin C, a protein kinase C inhibitor, increased PAR-2 [Ca(2+)](i) response.	calphostin C	0-12	F2R like trypsin receptor 1	Homo sapiens	54-59
11373280-11	2001	Pretreatment with 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine and calphostin C prevented the activation of ribose PRPP synthetase and PRPP pyrophosphatase as well as increase in Rib-1,5-P2 and activation of phosphofructokinase 30 s after hypoxia.	calphostin C	72-84	ribonuclease A family member 1, pancreatic	Homo sapiens	184-189
11422221-7	2001	The protein kinase C (PKC) inhibitors staurosporine (10-8 mol/L) and calphostin C (10-7 mol/L) markedly attenuated the ET-1-induced enhancement of NA responses.	calphostin C	69-81	endothelin 1	Rattus norvegicus	119-123
11298788-5	2001	NMDA-induced phosphorylation of MAP-2 was inhibited by the nitric oxide synthase inhibitors nitroarginine and 7-nitroindazole and by PD098059 (an inhibitor of MAP kinase kinase), but was only slightly reduced by calphostin C or U-73122, inhibitors of protein kinase C and of phospholipase C, respectively.	calphostin C	212-224	microtubule-associated protein 2	Rattus norvegicus	32-37
11382404-5	2001	However, calphostin C (a PKC inhibitor) and or SB203580 (a p38 inhibitor) partially but significantly reduced C2 ceramide-induced proENK mRNA expression as well as phospho-CREB level.	calphostin C	9-21	proenkephalin	Rattus norvegicus	130-136
11382404-5	2001	However, calphostin C (a PKC inhibitor) and or SB203580 (a p38 inhibitor) partially but significantly reduced C2 ceramide-induced proENK mRNA expression as well as phospho-CREB level.	calphostin C	9-21	cAMP responsive element binding protein 1	Rattus norvegicus	172-176
11278345-5	2001	Synaptosomal phosphorylation of NSF is stimulated by phorbol esters and is inhibited by staurosporine, chelerythrine, bisindolylmaleimide I, calphostin C, and Ro31-8220 but not the calmodulin kinase II inhibitor, Kn-93, suggesting a role for protein kinase C (PKC).	calphostin C	141-153	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Rattus norvegicus	32-35
11500953-9	2001	Calphostin C, a protein kinase C (PKC) inhibitor, significantly blunted the stimulatory effect of ET-1 on Pi transport.	calphostin C	0-12	endothelin 1	Mus musculus	98-102
11440364-7	2001	Activator protein 1 activation in response to either high glucose or co-stimulation with high glucose and Ang II was inhibited completely by calphostin C (a PKC inhibitor) and partially by genistein (a protein tyrosine kinase inhibitor).	calphostin C	141-153	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-19
11440364-7	2001	Activator protein 1 activation in response to either high glucose or co-stimulation with high glucose and Ang II was inhibited completely by calphostin C (a PKC inhibitor) and partially by genistein (a protein tyrosine kinase inhibitor).	calphostin C	141-153	angiotensinogen	Homo sapiens	106-112
11356906-6	2001	Selective PKC inhibitors, such as calphostin C and GF 109203X, and PKC-epsilon-specific translocation inhibitor peptide abrogated the enhancing effect of TPO on IL-3-dependent colony formation and the changes in the intracellular expression pattern of PKC-epsilon.	calphostin C	34-46	protein kinase C, alpha	Mus musculus	10-13
11356906-6	2001	Selective PKC inhibitors, such as calphostin C and GF 109203X, and PKC-epsilon-specific translocation inhibitor peptide abrogated the enhancing effect of TPO on IL-3-dependent colony formation and the changes in the intracellular expression pattern of PKC-epsilon.	calphostin C	34-46	thrombopoietin	Mus musculus	154-157
11336542-6	2001	Transfection with HCV-core in HepG2 cells stimulated the membrane translocation of protein kinase C (PKC) and the treatment of HCV-core transfected cells with calphostin C, a PKC inhibitor, blocked induction of Sp1 and Egr1 DNA binding activity, and eventually transcriptional transactivations of the IGF-II gene.	calphostin C	159-171	early growth response 1	Homo sapiens	219-223
11336542-6	2001	Transfection with HCV-core in HepG2 cells stimulated the membrane translocation of protein kinase C (PKC) and the treatment of HCV-core transfected cells with calphostin C, a PKC inhibitor, blocked induction of Sp1 and Egr1 DNA binding activity, and eventually transcriptional transactivations of the IGF-II gene.	calphostin C	159-171	insulin like growth factor 2	Homo sapiens	301-307
11239021-5	2001	Pre-incubation with specific protein kinase C (PKC) inhibitor calphostin C (1 micromol/l) significantly reduced the peak and the sustained elevations of [Ca(2+)]i. Pre-treatment with rHuEpo for 60 min increased both basal [Ca(2+)]i and the changes in [Ca(2+)]i by Ang II or NA in a dose-dependent manner in the presence of extracellular Ca(2+).	calphostin C	62-74	protein kinase C, gamma	Rattus norvegicus	29-45
11357881-5	2001	Cyclosporine A, herbimycin A, LY294002, calphostin C and PD98059 all inhibited anti-Thy-1-induced T lymphocyte proliferation, indicating the involvement of calcineurin, protein tyrosine kinases, phosphatidylinositol 3-kinase, protein kinase C, and MEK1 (MAPK kinase 1), respectively, in Thy-1 signaling.	calphostin C	40-52	thymus cell antigen 1, theta	Mus musculus	84-89
11181403-15	2001	alpha(1)-AR stimulation of NHE1 is inhibited by the protein kinase C (PKC) inhibitor calphostin C whereas NHE3 activity is abolished by the mitogen-activated protein kinase (MAPK) inhibitor PD-98059.	calphostin C	85-97	solute carrier family 9 member A1	Homo sapiens	27-31
11251195-5	2001	Potentiation of the f-EPSP is blocked by antagonists of mGluRs (MCPG) and PKC (calphostin-C, tamoxifen), suggesting that the potentiation of the f-EPSP is dependent on mGluRs and PKC.	calphostin C	79-91	protein kinase C, gamma	Rattus norvegicus	74-77
11251195-5	2001	Potentiation of the f-EPSP is blocked by antagonists of mGluRs (MCPG) and PKC (calphostin-C, tamoxifen), suggesting that the potentiation of the f-EPSP is dependent on mGluRs and PKC.	calphostin C	79-91	protein kinase C, gamma	Rattus norvegicus	179-182
11171620-6	2001	PLD activity was inhibited by calphostin C, bisindolylmaleimide I, and a selective protein kinase C (PKC)-alpha inhibitor; the inhibition was additive to that of ARF and RhoA antibodies and C3 exoenzyme.	calphostin C	30-42	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
11179511-9	2001	The phosphatidylinositol 3-kinase inhibitor wortmannin and the protein kinase (PK) C inhibitor calphostin-C significantly blunted the secretory responses ensuing from the activation of both receptor subtypes, while the Ca(2+)-channel blocker nifedipine was ineffective.	calphostin C	95-107	proline rich transmembrane protein 2	Homo sapiens	63-84
11239021-5	2001	Pre-incubation with specific protein kinase C (PKC) inhibitor calphostin C (1 micromol/l) significantly reduced the peak and the sustained elevations of [Ca(2+)]i. Pre-treatment with rHuEpo for 60 min increased both basal [Ca(2+)]i and the changes in [Ca(2+)]i by Ang II or NA in a dose-dependent manner in the presence of extracellular Ca(2+).	calphostin C	62-74	protein kinase C, gamma	Rattus norvegicus	47-50
11239021-5	2001	Pre-incubation with specific protein kinase C (PKC) inhibitor calphostin C (1 micromol/l) significantly reduced the peak and the sustained elevations of [Ca(2+)]i. Pre-treatment with rHuEpo for 60 min increased both basal [Ca(2+)]i and the changes in [Ca(2+)]i by Ang II or NA in a dose-dependent manner in the presence of extracellular Ca(2+).	calphostin C	62-74	angiotensinogen	Rattus norvegicus	264-270
11160843-5	2001	The intracellular concentration of annexin V increased with the addition of PKC activator (12-O:-tetradecanoylphorbor-13-acetate; TPA) much as it did with the addition of buserelin, and the rise in the concentration caused by the addition of buserelin was completely attenuated by pretreatment with PKC inhibitor (calphostin C).	calphostin C	314-326	annexin A5	Homo sapiens	35-44
11327888-4	2001	We examined the sensitivity of this process to widely used PKC inhibitors and report the surprising finding that calphostin-c is a potent direct inhibitor of PLD1 and PLD2.	calphostin C	113-125	phospholipase D1	Homo sapiens	158-162
11327888-4	2001	We examined the sensitivity of this process to widely used PKC inhibitors and report the surprising finding that calphostin-c is a potent direct inhibitor of PLD1 and PLD2.	calphostin C	113-125	phospholipase D2	Homo sapiens	167-171
11327888-5	2001	In vitro, calphostin-c inhibits activity of both PLD1 and PLD2 with an IC(50) of approximately 100 nM.	calphostin C	10-22	phospholipase D1	Homo sapiens	49-53
11327888-5	2001	In vitro, calphostin-c inhibits activity of both PLD1 and PLD2 with an IC(50) of approximately 100 nM.	calphostin C	10-22	phospholipase D2	Homo sapiens	58-62
11327888-8	2001	Inhibition of PLD by calphostin-c in vitro involves stable and apparently irreversible modification of the enzyme.	calphostin C	21-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-17
11327888-9	2001	Activity of both PLD1 and PLD2 can be inhibited by calphostin-c treatment of intact cells in a manner that is independent of upstream actions of PKC.	calphostin C	51-63	phospholipase D1	Homo sapiens	17-21
11327888-9	2001	Activity of both PLD1 and PLD2 can be inhibited by calphostin-c treatment of intact cells in a manner that is independent of upstream actions of PKC.	calphostin C	51-63	phospholipase D2	Homo sapiens	26-30
11327888-10	2001	Our results suggest that inhibition of PLD1 and PLD2 may explain some of the PKC-independent effects of calphostin-c observed when the compound is applied to intact cells.	calphostin C	104-116	phospholipase D1	Homo sapiens	39-43
11327888-10	2001	Our results suggest that inhibition of PLD1 and PLD2 may explain some of the PKC-independent effects of calphostin-c observed when the compound is applied to intact cells.	calphostin C	104-116	phospholipase D2	Homo sapiens	48-52
11150508-5	2000	The tyrosine kinase (TK) inhibitor tyrphostin-23 and the p42/p44 mitogen-activated protein kinase (MAPK) inhibitor PD-98059 abolished the proliferogenic effect of ET-1[1-31], while the protein kinase-C (PKC) inhibitor calphostin-C significantly reduced it.	calphostin C	218-230	mitogen activated protein kinase 3	Rattus norvegicus	61-64
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	calphostin C	118-130	protein kinase C alpha	Homo sapiens	79-82
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	calphostin C	118-130	protein kinase C alpha	Homo sapiens	101-104
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	calphostin C	118-130	angiotensinogen	Homo sapiens	185-191
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	calphostin C	118-130	protein kinase C alpha	Homo sapiens	101-104
11549852-6	2001	This inhibition of the NHE was prevented by pretreatment of the cells with either the intracellular calcium chelator, BAPTA or with the protein kinase C inhibitor, calphostin C.	calphostin C	164-176	solute carrier family 9 member C1	Homo sapiens	23-26
11150508-5	2000	The tyrosine kinase (TK) inhibitor tyrphostin-23 and the p42/p44 mitogen-activated protein kinase (MAPK) inhibitor PD-98059 abolished the proliferogenic effect of ET-1[1-31], while the protein kinase-C (PKC) inhibitor calphostin-C significantly reduced it.	calphostin C	218-230	mitogen activated protein kinase 3	Rattus norvegicus	99-103
11150508-7	2000	The stimulatory action of ET-1[1-31] on TK activity was annulled by tyrphostin-23, while that on MAPK activity was reduced by calphostin-C and abolished by either tyrphostin-23 and PD-98059.	calphostin C	126-138	mitogen activated protein kinase 3	Rattus norvegicus	97-101
11108260-5	2000	Calphostin C (a protein kinase C inhibitor) and KN93 (a Ca2+/calmodulin-dependent protein kinase inhibitor) also attenuated NE-mediated MAPK activation, but to a lesser degree.	calphostin C	0-12	mitogen activated protein kinase 3	Rattus norvegicus	136-140
11058567-7	2000	Involvement of PKC in the ET-1-induced contractile response is supported by the inhibition caused by the PKC inhibitor calphostin C.	calphostin C	119-131	protein kinase C alpha	Homo sapiens	15-18
11095605-9	2000	Maximum inhibition of PKC with staurosporine, calphostin C, and chelerythrine reduced cell proliferation to 7%, 31%, and 48% of control, respectively.	calphostin C	46-58	protein kinase C, gamma	Rattus norvegicus	22-25
11095605-12	2000	Cyclin E protein level was decreased to 70%, 38%, 57%, and 43% of control in cells treated with calphostin C, staurosporine, chelerythrine, and PKCalpha antisense, respectively.	calphostin C	96-108	cyclin E1	Rattus norvegicus	0-8
11058567-7	2000	Involvement of PKC in the ET-1-induced contractile response is supported by the inhibition caused by the PKC inhibitor calphostin C.	calphostin C	119-131	endothelin 1	Homo sapiens	26-30
11058567-7	2000	Involvement of PKC in the ET-1-induced contractile response is supported by the inhibition caused by the PKC inhibitor calphostin C.	calphostin C	119-131	protein kinase C alpha	Homo sapiens	105-108
10978848-6	2000	Staurosporine and calphostin C also inhibited the PRL effect by 50%, consistent with involvement of protein kinase C-(PKC)-alpha, the major PKC isoform in astrocytes.	calphostin C	18-30	prolactin	Homo sapiens	50-53
11089552-6	2000	ERK2 activation by PTH was blocked by the protein kinase C inhibitor calphostin-C but was unaffected by the protein kinase A inhibitor Rp-cAMPs.	calphostin C	69-81	mitogen-activated protein kinase 1	Homo sapiens	0-4
11089552-6	2000	ERK2 activation by PTH was blocked by the protein kinase C inhibitor calphostin-C but was unaffected by the protein kinase A inhibitor Rp-cAMPs.	calphostin C	69-81	parathyroid hormone	Homo sapiens	19-22
10978848-6	2000	Staurosporine and calphostin C also inhibited the PRL effect by 50%, consistent with involvement of protein kinase C-(PKC)-alpha, the major PKC isoform in astrocytes.	calphostin C	18-30	protein kinase C alpha	Homo sapiens	118-121
10922377-3	2000	Using calphostin C, a potent and selective inhibitor of protein kinase C and a recognized apoptosis inducer for various cell types, we demonstrate, by immunoblot analysis, that DLK protein levels are rapidly and dramatically down-regulated during the early phases of apoptosis.	calphostin C	6-18	mitogen-activated protein kinase kinase kinase 12	Mus musculus	177-180
10896658-7	2000	Furthermore, transfectants of catalytically inactive mutant of SHP-1 showed tyrosine phosphorylation of PLCgamma1 and mitogenic responses to HGF, and the mitogenic response was blocked with, an inhibitor of phosphatidylinositol-specific PLC, and calphostin C, an inhibitor of protein kinase C downstream of the PLCgamma1.	calphostin C	246-258	protein tyrosine phosphatase, non-receptor type 6	Rattus norvegicus	63-68
10922377-5	2000	Experiments aimed at elucidating the mechanism(s) underlying DLK oligomerization revealed that the tissue transglutaminase (tTG) inhibitor monodansylcadaverine antagonized the effects of calphostin C almost completely, thereby suggesting the involvement of a tTG-catalyzed reaction as the root cause of DLK down-regulation and accumulation as high molecular weight species.	calphostin C	187-199	mitogen-activated protein kinase kinase kinase 12	Mus musculus	61-64
10922377-5	2000	Experiments aimed at elucidating the mechanism(s) underlying DLK oligomerization revealed that the tissue transglutaminase (tTG) inhibitor monodansylcadaverine antagonized the effects of calphostin C almost completely, thereby suggesting the involvement of a tTG-catalyzed reaction as the root cause of DLK down-regulation and accumulation as high molecular weight species.	calphostin C	187-199	transglutaminase 2, C polypeptide	Mus musculus	99-122
10922377-5	2000	Experiments aimed at elucidating the mechanism(s) underlying DLK oligomerization revealed that the tissue transglutaminase (tTG) inhibitor monodansylcadaverine antagonized the effects of calphostin C almost completely, thereby suggesting the involvement of a tTG-catalyzed reaction as the root cause of DLK down-regulation and accumulation as high molecular weight species.	calphostin C	187-199	transglutaminase 2, C polypeptide	Mus musculus	124-127
11003572-3	2000	Phosphorylation of Galpha(i-1) and Galpha(i-2) and blockade of cyclase inhibition were reversed by calphostin C and bisindolylmaleimide, and additively by selective inhibitors of PKCalpha and PKCepsilon.	calphostin C	99-111	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	19-29
11003572-3	2000	Phosphorylation of Galpha(i-1) and Galpha(i-2) and blockade of cyclase inhibition were reversed by calphostin C and bisindolylmaleimide, and additively by selective inhibitors of PKCalpha and PKCepsilon.	calphostin C	99-111	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	35-45
11003572-3	2000	Phosphorylation of Galpha(i-1) and Galpha(i-2) and blockade of cyclase inhibition were reversed by calphostin C and bisindolylmaleimide, and additively by selective inhibitors of PKCalpha and PKCepsilon.	calphostin C	99-111	protein kinase C alpha	Homo sapiens	179-187
10979239-12	2000	ETA receptor-mediated aldosterone response was abolished by the protein kinase (PK) C inhibitor calphostin C (10(-5) mol/L).	calphostin C	96-108	endothelin receptor type A	Homo sapiens	0-3
10972960-5	2000	Pharmacological studies using the PKC activator, phorbol myristate acetate, and inhibitors, calphostin-C, and staurosporine, demonstrated PKC activity to be inversely related to NCAM polysialylation in the mouse neuro-2A cell line.	calphostin C	92-104	protein kinase C, delta	Mus musculus	138-141
10972960-5	2000	Pharmacological studies using the PKC activator, phorbol myristate acetate, and inhibitors, calphostin-C, and staurosporine, demonstrated PKC activity to be inversely related to NCAM polysialylation in the mouse neuro-2A cell line.	calphostin C	92-104	neural cell adhesion molecule 1	Mus musculus	178-182
10960082-7	2000	In that case the expression of the protein remained high at least up to 12 h. Treatment of cells with protein kinase C inhibitors (H-7, bisindolylmaleimide and calphostin C) inhibited IL-1beta stimulation of PGE(2).	calphostin C	160-172	interleukin 1 beta	Mus musculus	184-192
10945851-6	2000	Contraction was abolished by the protein kinase C (PKC) inhibitor calphostin C (1 microM), but was not affected by the myosin light chain kinase inhibitor KT5926 (1 microM), suggesting that activation of myosin light chain kinase was suppressed by phorbol-12-myristate-13-acetate or via PKC.	calphostin C	66-78	myosin light chain kinase, smooth muscle	Cavia porcellus	204-229
10947860-7	2000	Protein kinase C (PKC) inhibitors, such as calphostin C, chelerythrine or downregulation of PKC, blocked the effect of GHRH on K+ currents, whereas an acute activation of PKC by phorbol 12, 13-dibutyrate (1 micromol/L) mimicked the effect of GHRH.	calphostin C	43-55	growth hormone releasing hormone	Homo sapiens	119-123
11001174-6	2000	In addition, calphostin C as well as cytochalasin D effectively inhibited A23187-induced EPO release.	calphostin C	13-25	eosinophil peroxidase	Cavia porcellus	89-92
10889466-7	2000	Calphostin C, a specific PKC inhibitor, suppressed the VEGF secretion by ET-1.	calphostin C	0-12	vascular endothelial growth factor A	Mus musculus	55-59
10898764-3	2000	In contrast, sustained contraction was not affected by these inhibitors but was abolished by 1) the PKC inhibitors chelerythrine and calphostin C, 2) PKC-epsilon antibody, and 3) a pseudosubstrate PKC-epsilon inhibitor.	calphostin C	133-145	protein kinase C alpha	Homo sapiens	100-103
10822274-1	2000	Calphostin C-mediated apoptosis in glioma cells was reported previously to be associated with down-regulation of Bcl-2 and Bcl-xL.	calphostin C	0-12	BCL2 apoptosis regulator	Homo sapiens	113-118
10822274-1	2000	Calphostin C-mediated apoptosis in glioma cells was reported previously to be associated with down-regulation of Bcl-2 and Bcl-xL.	calphostin C	0-12	BCL2 like 1	Homo sapiens	123-129
10822274-2	2000	In this study, we report that 100 nM calphostin C also induces translocation and integration of monomeric Bax into mitochondrial membrane, followed by cytochrome c release into cytosol and subsequent decrease of mitochondrial inner membrane potential (DeltaPsim) before activation of caspase-3.	calphostin C	37-49	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
10822274-2	2000	In this study, we report that 100 nM calphostin C also induces translocation and integration of monomeric Bax into mitochondrial membrane, followed by cytochrome c release into cytosol and subsequent decrease of mitochondrial inner membrane potential (DeltaPsim) before activation of caspase-3.	calphostin C	37-49	cytochrome c, somatic	Homo sapiens	151-163
10822274-2	2000	In this study, we report that 100 nM calphostin C also induces translocation and integration of monomeric Bax into mitochondrial membrane, followed by cytochrome c release into cytosol and subsequent decrease of mitochondrial inner membrane potential (DeltaPsim) before activation of caspase-3.	calphostin C	37-49	caspase 3	Homo sapiens	284-293
10903877-9	2000	Activation of PKA by 8-bromo-cyclic AMP or forskolin, and inhibition of PKC by calphostin C, resulted in a significant decrease in 3TP activity as well as in vitro ERK kinase activity in CRAC.	calphostin C	79-91	Eph receptor B1	Rattus norvegicus	164-167
10889466-7	2000	Calphostin C, a specific PKC inhibitor, suppressed the VEGF secretion by ET-1.	calphostin C	0-12	endothelin 1	Mus musculus	73-77
10822274-6	2000	Therefore, it would be assumed that mitochondrial release of cytochrome c results from translocation and integration of Bax and is independent of permeability transition of mitochondria and caspase activation, representing a critical step in calphostin C-induced cell death.	calphostin C	242-254	cytochrome c, somatic	Homo sapiens	61-73
10822274-6	2000	Therefore, it would be assumed that mitochondrial release of cytochrome c results from translocation and integration of Bax and is independent of permeability transition of mitochondria and caspase activation, representing a critical step in calphostin C-induced cell death.	calphostin C	242-254	BCL2 associated X, apoptosis regulator	Homo sapiens	120-123
10809726-5	2000	Calphostin C, an inhibitor of protein kinase C, blocked the induction of COX-2 by MIAs.	calphostin C	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-78
10818070-6	2000	PKC inhibitors calphostin C (100 nmol/L) and chelerythrine (1 micromol/L) each inhibited high glucose-induced, PDGF BB-mediated SMC migration.	calphostin C	15-27	proline rich transmembrane protein 2	Homo sapiens	0-3
10818070-7	2000	High glucose-induced suppression of insulin-mediated [(3)H]-deoxyglucose uptake, which was blocked by both calphostin C (100 nmol/L) and chelerythrine (1 micromol/L), was decreased by epalrestat (100 nmol/L).	calphostin C	107-119	insulin	Homo sapiens	36-43
10813386-4	2000	In contrast, the Ca2+-sensitizing effect of ET-1 was significantly inhibited by either calphostin C or genistein.	calphostin C	87-99	endothelin-1	Oryctolagus cuniculus	44-48
10813386-5	2000	Although the inhibitory effect of calphostin C on ET-1-induced Ca2+ sensitization was less than that of genistein, the effects of calphostin C and genistein were additive.	calphostin C	34-46	endothelin-1	Oryctolagus cuniculus	50-54
10813386-8	2000	In beta-escin-skinned smooth muscle of rabbit mesenteric artery, ET-1-induced Ca2+ sensitization was marginally affected by C3 pretreatment, calphostin C, and genistein.	calphostin C	141-153	endothelin-1	Oryctolagus cuniculus	65-69
10751199-7	2000	Additions of 1 microM calphostin C, a PKC-specific inhibitor, at the beginning or > or =5 h, but not > or = 9 h, after the initiation of lipoprotein treatment, blocked native and oxidized LDL- or Lp(a)-induced increases in PKC activity and PAI-1 production.	calphostin C	22-34	protein kinase C beta	Homo sapiens	38-41
10790161-7	2000	The PKC inhibitors Ro-31-8220 (1 microM) and calphostin C (250 nM) completely blocked the stimulation of Ca2+ spiking by either PMA or AVP.	calphostin C	45-57	protein kinase C, alpha	Rattus norvegicus	4-7
10751199-7	2000	Additions of 1 microM calphostin C, a PKC-specific inhibitor, at the beginning or > or =5 h, but not > or = 9 h, after the initiation of lipoprotein treatment, blocked native and oxidized LDL- or Lp(a)-induced increases in PKC activity and PAI-1 production.	calphostin C	22-34	serpin family E member 1	Homo sapiens	246-251
10751199-7	2000	Additions of 1 microM calphostin C, a PKC-specific inhibitor, at the beginning or > or =5 h, but not > or = 9 h, after the initiation of lipoprotein treatment, blocked native and oxidized LDL- or Lp(a)-induced increases in PKC activity and PAI-1 production.	calphostin C	22-34	lipoprotein(a)	Homo sapiens	202-207
10751199-7	2000	Additions of 1 microM calphostin C, a PKC-specific inhibitor, at the beginning or > or =5 h, but not > or = 9 h, after the initiation of lipoprotein treatment, blocked native and oxidized LDL- or Lp(a)-induced increases in PKC activity and PAI-1 production.	calphostin C	22-34	protein kinase C beta	Homo sapiens	229-232
10982151-1	2000	Previous studies have confirmed that proliferation in glioblastoma cell lines can be blocked by non-isoform specific protein kinase C (PKC) inhibitors, e.g calphostin C, staurosporine.	calphostin C	156-168	proline rich transmembrane protein 2	Homo sapiens	117-133
10797562-10	2000	Furthermore, calphostin C, a specific protein kinase C (PKC) inhibitor, decreased TPA-treated JB6 cell adhesion to OPN by 50%, suggesting that TPA increased integrin affinity or avidity for OPN through a PKC-mediated pathway.	calphostin C	13-25	secreted phosphoprotein 1	Homo sapiens	115-118
10797562-10	2000	Furthermore, calphostin C, a specific protein kinase C (PKC) inhibitor, decreased TPA-treated JB6 cell adhesion to OPN by 50%, suggesting that TPA increased integrin affinity or avidity for OPN through a PKC-mediated pathway.	calphostin C	13-25	secreted phosphoprotein 1	Homo sapiens	190-193
10982151-1	2000	Previous studies have confirmed that proliferation in glioblastoma cell lines can be blocked by non-isoform specific protein kinase C (PKC) inhibitors, e.g calphostin C, staurosporine.	calphostin C	156-168	proline rich transmembrane protein 2	Homo sapiens	135-138
10719304-13	2000	GQ1b-induced increases in IL-6 and IL-10 production of T cells were both blocked by PKC inhibitors, calphostin C and staurosporine.	calphostin C	100-112	interleukin 6	Homo sapiens	26-30
10719304-13	2000	GQ1b-induced increases in IL-6 and IL-10 production of T cells were both blocked by PKC inhibitors, calphostin C and staurosporine.	calphostin C	100-112	interleukin 10	Homo sapiens	35-40
10681570-12	2000	Ox-LDL-induced expression of GM-CSF and its subsequent release were inhibited by calphostin C but not by wortmannin, whereas recombinant GM-CSF-induced macrophage proliferation was inhibited by wortmannin by 50% but not by calphostin C.	calphostin C	81-93	colony stimulating factor 2	Homo sapiens	29-35
10679516-8	2000	Calphostin C and ET-18-OCH(3), inhibitors of protein kinase C, reduced the phosphorylation of p38 MAP kinase by AVP.	calphostin C	0-12	mitogen-activated protein kinase 14	Homo sapiens	94-108
10681570-12	2000	Ox-LDL-induced expression of GM-CSF and its subsequent release were inhibited by calphostin C but not by wortmannin, whereas recombinant GM-CSF-induced macrophage proliferation was inhibited by wortmannin by 50% but not by calphostin C.	calphostin C	223-235	colony stimulating factor 2	Homo sapiens	29-35
10681570-12	2000	Ox-LDL-induced expression of GM-CSF and its subsequent release were inhibited by calphostin C but not by wortmannin, whereas recombinant GM-CSF-induced macrophage proliferation was inhibited by wortmannin by 50% but not by calphostin C.	calphostin C	223-235	colony stimulating factor 2	Homo sapiens	137-143
10657658-7	2000	Activation of protein kinase C (PKC) was required because calphostin C inhibited NF-kappa B activation and I kappa B alpha phosphorylation.	calphostin C	58-70	protein kinase C zeta	Homo sapiens	32-35
10657658-7	2000	Activation of protein kinase C (PKC) was required because calphostin C inhibited NF-kappa B activation and I kappa B alpha phosphorylation.	calphostin C	58-70	nuclear factor kappa B subunit 1	Homo sapiens	81-91
10657658-7	2000	Activation of protein kinase C (PKC) was required because calphostin C inhibited NF-kappa B activation and I kappa B alpha phosphorylation.	calphostin C	58-70	NFKB inhibitor alpha	Homo sapiens	107-122
10623882-7	2000	This increase in E-cadherin expression was completely inhibited by Calphostin C (PKC inhibitor) and KN-62 (CaMK inhibitor), but not by H-89 (PKA inhibitor), indicating that SP-induced E-cadherin expression involves the activation of protein kinase C (PKC) and calmodulin kinase (CaMK).	calphostin C	67-79	cadherin 1	Homo sapiens	17-27
10623882-7	2000	This increase in E-cadherin expression was completely inhibited by Calphostin C (PKC inhibitor) and KN-62 (CaMK inhibitor), but not by H-89 (PKA inhibitor), indicating that SP-induced E-cadherin expression involves the activation of protein kinase C (PKC) and calmodulin kinase (CaMK).	calphostin C	67-79	proline rich transmembrane protein 2	Homo sapiens	81-84
10623882-7	2000	This increase in E-cadherin expression was completely inhibited by Calphostin C (PKC inhibitor) and KN-62 (CaMK inhibitor), but not by H-89 (PKA inhibitor), indicating that SP-induced E-cadherin expression involves the activation of protein kinase C (PKC) and calmodulin kinase (CaMK).	calphostin C	67-79	tachykinin precursor 1	Homo sapiens	173-175
10690956-11	2000	Furthermore, the insulinotropic effect of ET-1 at 16.7 mmol/L glucose was counteracted by the PKC inhibitor Calphostin C (P < .05) and by downregulation of PKC by 24 hours of exposure of islets to TPA (0.5 micromol/L, P < .05).	calphostin C	108-120	endothelin 1	Mus musculus	42-46
10683529-5	2000	The PMA-induced astrocyte stellation and ERK1/2 phosphorylation were blocked by specific PKC inhibitors, GF-109203X (0.01-1 microM) and calphostin C (1 microM).	calphostin C	136-148	mitogen activated protein kinase 3	Rattus norvegicus	41-47
11448065-4	2000	Anti-MMP-9 antibodies, TIMP-1, the synthetic MMPs inhibitor Batimastat (BB-94), and the PKC inhibitor calphostin-C all reduced MMP-9 activity and capillary network formation in these cocultures.	calphostin C	102-114	matrix metallopeptidase 9	Homo sapiens	127-132
10718910-9	2000	The GHRH-induced reduction in the K+ current was completely abolished by the presence of GDP-beta-s (500 microM) in the pipette solution or by addition of PKC inhibitors, calphostin C (100 nM) and chelerythrine (1 microM), in bath solution.	calphostin C	171-183	growth hormone releasing hormone	Rattus norvegicus	4-8
10657432-4	2000	METHODS: PD-98059, damnacanthal, wortmannin, AG-490, genistein, calphostin C, and staurosporine were used to inhibit, or relax, the ET-1-induced contraction of basilar artery, studied with an isometric tension system.	calphostin C	64-76	endothelin-1	Oryctolagus cuniculus	132-136
10625638-9	2000	Calphostin C, a selective inhibitor of PKC, decreased the PMA-, PTH-, and IGF-I-induced luciferase activity in a dose-dependent manner; a PKA inhibitor, H-89, also blocked the induction by PTH and IGF-I but not by PMA.	calphostin C	0-12	insulin like growth factor 1	Homo sapiens	74-79
10625638-9	2000	Calphostin C, a selective inhibitor of PKC, decreased the PMA-, PTH-, and IGF-I-induced luciferase activity in a dose-dependent manner; a PKA inhibitor, H-89, also blocked the induction by PTH and IGF-I but not by PMA.	calphostin C	0-12	insulin like growth factor 1	Homo sapiens	197-202
10627456-8	2000	The PKC inhibitors staurosporine and calphostin C prevented EPO-induced erythroid differentiation.	calphostin C	37-49	protein kinase C alpha	Homo sapiens	4-7
10627456-8	2000	The PKC inhibitors staurosporine and calphostin C prevented EPO-induced erythroid differentiation.	calphostin C	37-49	erythropoietin	Homo sapiens	60-63
10728373-11	2000	Pretreatment of the cells with calphostin C (100-400 nmol/l) and chelerythrine chloride (5-10 mumol/l), inhibitors of PKC, abolished the superoxide anion-induced NF-kappa B activation.	calphostin C	31-43	nuclear factor kappa B subunit 1	Homo sapiens	162-172
10572244-7	1999	Calphostin C, a specific inhibitor of PKC, suppressed the PGF(2alpha)-induced HSP27 accumulation as well as that induced by TPA.	calphostin C	0-12	heat shock protein 1	Mus musculus	78-83
10601572-7	2000	The aldosterone secretagogue action of 10-8 M ET-1 on dispersed ZG cells was concentration-dependently suppressed by the protein kinase (PK) inhibitor calphostin-C.	calphostin C	151-163	endothelin 1	Rattus norvegicus	46-50
10601572-8	2000	Conversely, both calphostin-C and the nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) evoked a concentration-dependent partial reversal of the aldosterone response to 10-8 M ET-1 of capsule-ZG strips.	calphostin C	17-29	endothelin 1	Rattus norvegicus	211-215
10604989-3	2000	The induction of MKP-1 was blocked by genistein, a tyrosine kinase inhibitor, and by two different protein kinase C (PKC) inhibitors (GF109203X and calphostin C).	calphostin C	148-160	dual specificity phosphatase 1	Homo sapiens	17-22
10600794-11	1999	Calphostin C and U-73122, a phospholipase C inhibitor, suppressed the ET-1-induced phosphorylation of p38 MAP kinase.	calphostin C	0-12	mitogen-activated protein kinase 14	Mus musculus	102-105
10640689-4	1999	The S1P-induced Egr-1 expression was partially inhibited by treatment of the cells with either calphostin C, an inhibitor of protein kinase C (PKC), or pertussis toxin (PTX), and completely inhibited by the combination of these agents.	calphostin C	95-107	early growth response 1	Rattus norvegicus	16-21
10588651-4	1999	Two-dimensional isoelectric focusing/SDS-polyacrylamide gels were used to determine that fascin became phosphorylated in cells adherent to fibronectin and was inhibited by the PKC inhibitors calphostin C and chelerythrine chloride.	calphostin C	191-203	fascin actin-bundling protein 1	Sus scrofa	89-95
10565839-5	1999	Whereas the PKC inhibitor staurosporine (3 microM) inhibited ERK activation by NPY, the chemically distinct PKC inhibitors calphostin C (3 microM), Go 6976 (3 microM), and bisindolylmaleimide I (3 microM) did not.	calphostin C	123-135	proline rich transmembrane protein 2	Homo sapiens	108-111
10600794-5	1999	Both staurosporine and calphostin C, inhibitors of protein kinase C (PKC), suppressed the ET-1-induced HSP 27 accumulation.	calphostin C	23-35	endothelin 1	Mus musculus	90-94
10600794-5	1999	Both staurosporine and calphostin C, inhibitors of protein kinase C (PKC), suppressed the ET-1-induced HSP 27 accumulation.	calphostin C	23-35	heat shock protein 1	Mus musculus	103-109
10600794-11	1999	Calphostin C and U-73122, a phospholipase C inhibitor, suppressed the ET-1-induced phosphorylation of p38 MAP kinase.	calphostin C	0-12	endothelin 1	Mus musculus	70-74
10589684-7	1999	However, calcitonin-induced CYP27B1 mRNA expression was only inhibited by the protein kinase C inhibitors staurosporine and calphostin C.	calphostin C	124-136	cytochrome P450 family 27 subfamily B member 1	Sus scrofa	28-35
10618646-11	1999	A specific PKC inhibitor, calphostin C (0.1 microM), diminished cyclic strain-stimulated MCP-1 mRNA expression.	calphostin C	26-38	C-C motif chemokine ligand 2	Rattus norvegicus	89-94
10588651-4	1999	Two-dimensional isoelectric focusing/SDS-polyacrylamide gels were used to determine that fascin became phosphorylated in cells adherent to fibronectin and was inhibited by the PKC inhibitors calphostin C and chelerythrine chloride.	calphostin C	191-203	protein kinase C, alpha	Mus musculus	176-179
10537140-6	1999	Calphostin C, a specific inhibitor of PKC, or D-609, a specific inhibitor of PC-PLC, significantly enhanced the IL-1alpha-induced phosphorylation of p42/p44 MAP kinase without affecting the phosphorylation of p38 MAP kinase.	calphostin C	0-12	interleukin 1 alpha	Mus musculus	112-121
10537140-6	1999	Calphostin C, a specific inhibitor of PKC, or D-609, a specific inhibitor of PC-PLC, significantly enhanced the IL-1alpha-induced phosphorylation of p42/p44 MAP kinase without affecting the phosphorylation of p38 MAP kinase.	calphostin C	0-12	cyclin-dependent kinase 20	Mus musculus	149-152
10537140-6	1999	Calphostin C, a specific inhibitor of PKC, or D-609, a specific inhibitor of PC-PLC, significantly enhanced the IL-1alpha-induced phosphorylation of p42/p44 MAP kinase without affecting the phosphorylation of p38 MAP kinase.	calphostin C	0-12	mitogen-activated protein kinase 3	Mus musculus	153-156
10537140-6	1999	Calphostin C, a specific inhibitor of PKC, or D-609, a specific inhibitor of PC-PLC, significantly enhanced the IL-1alpha-induced phosphorylation of p42/p44 MAP kinase without affecting the phosphorylation of p38 MAP kinase.	calphostin C	0-12	mitogen-activated protein kinase 14	Mus musculus	209-212
10580807-4	1999	Using a competitive RT-PCR, we examined the IL-17-induced IkappaB-alpha mRNA expression in glioblastoma cells, and we examined IL-17 up-regulated IkappaB-alpha mRNA expression in a dose- and time-dependent fashion with a maximum time between 1 and 3 h. This induction could be inhibited by Calphostin C (protein kinase C inhibitor) and genistein (tyrosine kinase inhibitor).	calphostin C	290-302	interleukin 17A	Homo sapiens	127-132
10545137-16	1999	While the application of protein kinase C (PKC) inhibitors calphostin C (100 nM) or chelerythrine (1 microM) did not affect the amplitude of the K+ currents, the K+ current response to GHRH was significantly attenuated.	calphostin C	59-71	growth hormone releasing hormone	Homo sapiens	185-189
10523856-6	1999	TPA-mediated MDR1 induction was inhibited by several PKC inhibitors including staurosporine, H7 and calphostin C.	calphostin C	100-112	ATP binding cassette subfamily B member 1	Homo sapiens	13-17
10630630-7	1999	However, calphostin C, a specific inhibitor of PKC, abolished the TPA-induced increase in CFI mRNA levels.	calphostin C	9-21	complement factor I	Homo sapiens	90-93
10630630-13	1999	The enhancement of the activity of transfected chimeric CAT constructs by TPA was abrogated by calphostin C and by pyrrolidine dithiocarbamate (an inhibitor of NF-kappaB and AP-1 transactivation).	calphostin C	95-107	catalase	Homo sapiens	56-59
10529383-6	1999	AGEs-induced gene expression of PPAR gamma and the signal intensity of PPAR gamma and PPRE complex were attenuated furthermore by protein kinase C inhibitors, calphostin C and staurospolin, but not abolished completely, indicating that both signal transduction pathways through the induction of PKC activation and independent of PKC activation were involved in the AGEs-mediated expression and activation process of PPAR gamma.	calphostin C	159-171	peroxisome proliferator activated receptor gamma	Homo sapiens	32-42
10529383-6	1999	AGEs-induced gene expression of PPAR gamma and the signal intensity of PPAR gamma and PPRE complex were attenuated furthermore by protein kinase C inhibitors, calphostin C and staurospolin, but not abolished completely, indicating that both signal transduction pathways through the induction of PKC activation and independent of PKC activation were involved in the AGEs-mediated expression and activation process of PPAR gamma.	calphostin C	159-171	peroxisome proliferator activated receptor gamma	Homo sapiens	71-81
10529383-6	1999	AGEs-induced gene expression of PPAR gamma and the signal intensity of PPAR gamma and PPRE complex were attenuated furthermore by protein kinase C inhibitors, calphostin C and staurospolin, but not abolished completely, indicating that both signal transduction pathways through the induction of PKC activation and independent of PKC activation were involved in the AGEs-mediated expression and activation process of PPAR gamma.	calphostin C	159-171	peroxisome proliferator activated receptor gamma	Homo sapiens	71-81
10523856-6	1999	TPA-mediated MDR1 induction was inhibited by several PKC inhibitors including staurosporine, H7 and calphostin C.	calphostin C	100-112	protein kinase C alpha	Homo sapiens	53-56
10582659-5	1999	On the other hand, calphostin C, a specific inhibitor of protein kinase C (PKC), enhanced the synthesis of IL-6 induced by PGD2.	calphostin C	19-31	interleukin 6	Mus musculus	107-111
10516105-9	1999	Calphostin C inhibited 73% of ET-1-induced Gardos activation and 84% of the ET-1-induced membrane protein kinase C activity.	calphostin C	0-12	endothelin 1	Mus musculus	30-34
10516105-9	1999	Calphostin C inhibited 73% of ET-1-induced Gardos activation and 84% of the ET-1-induced membrane protein kinase C activity.	calphostin C	0-12	endothelin 1	Mus musculus	76-80
10482351-10	1999	1 microM calphostin C, a broad range PKC inhibitor, significantly reduced both PdBu (1 microM) and nicergoline (10 microM) induced APPs release.	calphostin C	9-21	protein kinase C alpha	Homo sapiens	37-40
10482351-10	1999	1 microM calphostin C, a broad range PKC inhibitor, significantly reduced both PdBu (1 microM) and nicergoline (10 microM) induced APPs release.	calphostin C	9-21	cathepsin B	Homo sapiens	131-135
10502402-7	1999	The PKC inhibitors staurosporine and calphostin C, and the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002, also prevented TRAIL mRNA transcription by activated T cells, indicating a role for PKC and PI3-K.	calphostin C	37-49	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	148-153
10501196-6	1999	Preincubation with selective protein kinase C inhibitors, staurosporine or calphostin C, depressed the response of epsilon1/zeta1 and epsilon2/zeta1 receptors to insulin.	calphostin C	75-87	insulin S homeolog	Xenopus laevis	162-169
10446931-4	1999	Treatment with 100 nM calphostin C or 50 microM KN-93 partially reversed the calcitonin effect on NAG release.	calphostin C	22-34	Calcitonin gene-related peptide	Sus scrofa	77-87
10468528-7	1999	In contrast, necrosis became the predominant form of cell death when PKC had been downregulated by prolonged exposure to 200 nmol/L phorbol 12,13-dibutyrate or inhibited by 50 nmol/L staurosporine, 100 nmol/L calphostin C, or 30 micromol/L H-7.	calphostin C	209-221	protein kinase C, gamma	Rattus norvegicus	69-72
10475376-11	1999	These studies also demonstrated that calphostin C induced apoptosis by a mechanism independent of p53 and pRb status and the presence or absence of 9p21 deletions.	calphostin C	37-49	tumor protein p53	Homo sapiens	98-101
10455189-10	1999	Phorbol 12-myristate 13-acetate also induced HEF1 tyrosine phosphorylation, and the protein kinase C inhibitor calphostin C completely inhibited both calcitonin- and phorbol 12-myristate 13-acetate-stimulated HEF1 phosphorylation.	calphostin C	111-123	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	209-213
10423413-10	1999	Although HBECs required stimulation by both CSE and C5a to release maximal levels of IL-8, preincubation of CSE-stimulated HBECs with calphostin C inhibited IL-8 release by CSE + C5a.	calphostin C	134-146	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
10423413-10	1999	Although HBECs required stimulation by both CSE and C5a to release maximal levels of IL-8, preincubation of CSE-stimulated HBECs with calphostin C inhibited IL-8 release by CSE + C5a.	calphostin C	134-146	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
10423413-10	1999	Although HBECs required stimulation by both CSE and C5a to release maximal levels of IL-8, preincubation of CSE-stimulated HBECs with calphostin C inhibited IL-8 release by CSE + C5a.	calphostin C	134-146	complement C5a receptor 1	Homo sapiens	179-182
10446064-5	1999	Depletion of protein kinase C (PKC) by phorbol 12-myristate 13 acetate or inhibition of PKC by calphostin C blocked MKP-1 induction, but the phospholipase C inhibitor U73122 had no effect.	calphostin C	95-107	dual specificity phosphatase 1	Homo sapiens	116-121
10406836-11	1999	The pressure-induced expression of c-fos was not inhibited by nitrendipine (10 micromol/L), a calcium-free Krebs" solution containing EGTA (1 to 2 mmol/L), calphostin C (0.1 micromol/L), or cytochalasin D (0.4 micromol/L) but was inhibited by genistein (30 micromol/L).	calphostin C	156-168	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-40
10440099-7	1999	A selective protein kinase C inhibitor, calphostin C (10(-6) M) partially and significantly prevented angiotensin II-induced increases in these parameters, and treatment with both lovastatin and calphostin C inhibited completely.	calphostin C	40-52	angiotensinogen	Rattus norvegicus	102-116
10373480-5	1999	mAChR-mediated myosin reorganization is abolished by inhibiting conventional PKC isoforms with Go6976 (IC50 = 0.4 microM), calphostin C (IC50 = 2.4 microM), or chelerythrine (IC50 = 8.0 microM).	calphostin C	123-135	myosin heavy chain 14	Homo sapiens	15-21
10487327-4	1999	ET-1 activated ERKs, which were followed by an increase in protein synthesis, and inhibition of protein kinase C activities by calphostin C completely suppressed the ET-1-induced ERK activation.	calphostin C	127-139	endothelin 1	Rattus norvegicus	166-170
10354503-4	1999	The specific PKC inhibitor, calphostin C, significantly inhibited medium levels of EPO and EPO mRNA levels in Hep3B cells exposed to 1% O2.	calphostin C	28-40	protein kinase C alpha	Homo sapiens	13-16
10354503-4	1999	The specific PKC inhibitor, calphostin C, significantly inhibited medium levels of EPO and EPO mRNA levels in Hep3B cells exposed to 1% O2.	calphostin C	28-40	erythropoietin	Homo sapiens	83-86
10354503-4	1999	The specific PKC inhibitor, calphostin C, significantly inhibited medium levels of EPO and EPO mRNA levels in Hep3B cells exposed to 1% O2.	calphostin C	28-40	erythropoietin	Homo sapiens	91-94
10465686-8	1999	ACPD-induced HO-1 expression was inhibited by the mGluR antagonist MCPG and the protein kinase C (PKC) inhibitor calphostin C.	calphostin C	113-125	heme oxygenase 1	Rattus norvegicus	13-17
10364070-4	1999	These LPL effects were abrogated by the specific protein kinase C inhibitor calphostin C (1 micromol/L).	calphostin C	76-88	lipoprotein lipase	Homo sapiens	6-9
10092616-12	1999	The effect of TNF-alpha and SMase was inhibited by the kinase inhibitor staurosporin and by the protein kinase C (PKC) inhibitor calphostin C but not by down-regulation of PKC.	calphostin C	129-141	tumor necrosis factor	Rattus norvegicus	14-23
10593574-2	1999	The functional sizes of agonist-sensitive intracellular Ca2+ store were estimated as the peak response to agonist after PKC inhibition with calphostin C (Cal-C), a PKC inhibitor.	calphostin C	154-159	protein kinase C, gamma	Rattus norvegicus	164-167
10376804-4	1999	Calphostin C, a highly potent and specific inhibitor of PKC, inhibited the PGF2alpha-induced p42/p44 MAP kinase activity.	calphostin C	0-12	cyclin-dependent kinase 20	Mus musculus	93-96
10376804-4	1999	Calphostin C, a highly potent and specific inhibitor of PKC, inhibited the PGF2alpha-induced p42/p44 MAP kinase activity.	calphostin C	0-12	mitogen-activated protein kinase 3	Mus musculus	97-100
10223197-9	1999	Calphostin C, a specific inhibitor of protein kinase C (PKC), inhibited activation of AP-1, demonstrating that PKC is involved in the cell signal cascades leading to vanadate-induced AP-1 activation.	calphostin C	0-12	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
10221543-6	1999	Calphostin C, a highly specific inhibitor of protein kinase C, suppressed endothelin-1-stimulated p42/p44 MAP kinase activation as well as endothelin-1-induced IL-6 synthesis.	calphostin C	0-12	endothelin 1	Mus musculus	74-86
10221543-6	1999	Calphostin C, a highly specific inhibitor of protein kinase C, suppressed endothelin-1-stimulated p42/p44 MAP kinase activation as well as endothelin-1-induced IL-6 synthesis.	calphostin C	0-12	cyclin-dependent kinase 20	Mus musculus	98-101
10221543-6	1999	Calphostin C, a highly specific inhibitor of protein kinase C, suppressed endothelin-1-stimulated p42/p44 MAP kinase activation as well as endothelin-1-induced IL-6 synthesis.	calphostin C	0-12	mitogen-activated protein kinase 3	Mus musculus	102-105
10221543-6	1999	Calphostin C, a highly specific inhibitor of protein kinase C, suppressed endothelin-1-stimulated p42/p44 MAP kinase activation as well as endothelin-1-induced IL-6 synthesis.	calphostin C	0-12	endothelin 1	Mus musculus	139-151
10221543-6	1999	Calphostin C, a highly specific inhibitor of protein kinase C, suppressed endothelin-1-stimulated p42/p44 MAP kinase activation as well as endothelin-1-induced IL-6 synthesis.	calphostin C	0-12	interleukin 6	Mus musculus	160-164
10223197-9	1999	Calphostin C, a specific inhibitor of protein kinase C (PKC), inhibited activation of AP-1, demonstrating that PKC is involved in the cell signal cascades leading to vanadate-induced AP-1 activation.	calphostin C	0-12	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-187
10082482-5	1999	ET-1-induced increase in cyclin D1 protein, and cdk4 kinase activity was not significantly inhibited by an inhibitor of the mitogen-activated protein kinase kinase 1/2, PD98059, nor by the protein kinase C inhibitor calphostin C, whereas ET-1-induced upregulation of cyclin D1 protein and cdk4 kinase activity was significantly inhibited by the phosphatidylinositol 3-kinase inhibitor LY294002.	calphostin C	216-228	endothelin 1	Mus musculus	0-4
10082482-6	1999	In contrast, ET-1-induced activation of cdk2 kinase was significantly inhibited by PD98059, calphostin C, and LY294002.	calphostin C	92-104	endothelin 1	Mus musculus	13-17
10082482-6	1999	In contrast, ET-1-induced activation of cdk2 kinase was significantly inhibited by PD98059, calphostin C, and LY294002.	calphostin C	92-104	cyclin-dependent kinase 2	Mus musculus	40-44
10082482-8	1999	ET-1-induced increase in 3H-thymidine uptake was significantly inhibited by PD98059, calphostin C, and LY294002.	calphostin C	85-97	endothelin 1	Mus musculus	0-4
10077523-6	1999	Probucol, alpha-tocopherol, and calphostin C improved the high glucose-induced suppression of insulin-mediated [3H]deoxyglucose uptake.	calphostin C	32-44	insulin	Oryctolagus cuniculus	94-101
10037458-4	1999	The PKC inhibitor calphostin C inhibited NF-kappaB activation by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in Jurkat or NIH3T3 cells but not in MCF7 A/Z cells.	calphostin C	18-30	proline rich transmembrane protein 2	Homo sapiens	4-7
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	calphostin C	186-198	interleukin 1 beta	Homo sapiens	0-9
10037458-4	1999	The PKC inhibitor calphostin C inhibited NF-kappaB activation by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in Jurkat or NIH3T3 cells but not in MCF7 A/Z cells.	calphostin C	18-30	tumor necrosis factor	Homo sapiens	65-98
10037458-4	1999	The PKC inhibitor calphostin C inhibited NF-kappaB activation by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in Jurkat or NIH3T3 cells but not in MCF7 A/Z cells.	calphostin C	18-30	interleukin 1 beta	Homo sapiens	102-124
10037491-3	1999	Treatment of microglia with A beta (25-35) at 10 nM or 12-O-tetradecanoylphorbol 13-acetate (1.6 nM) led to phosphorylation of MARCKS, an event inhibited by PKC inhibitors, staurosporine, calphostin C, and chelerythrine.	calphostin C	188-200	amyloid beta precursor protein	Rattus norvegicus	28-34
10037491-3	1999	Treatment of microglia with A beta (25-35) at 10 nM or 12-O-tetradecanoylphorbol 13-acetate (1.6 nM) led to phosphorylation of MARCKS, an event inhibited by PKC inhibitors, staurosporine, calphostin C, and chelerythrine.	calphostin C	188-200	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	127-133
10051543-3	1999	Pretreatment with calphostin C, a specific PKC inhibitor, prevented oxidant generation after TNF-alpha stimulation, indicating that PKC activation mediated the production of oxidants in HPAE cells.	calphostin C	18-30	tumor necrosis factor	Homo sapiens	93-102
10051543-6	1999	However, both PKC activation and oxidant generation were necessary for ICAM-1 mRNA expression because the pretreatment of HPAE cells with either calphostin C or N-acetylcysteine inhibited the TNF-alpha-induced activation of NF-kappaB and prevented the activation of ICAM-1 promoter.	calphostin C	145-157	intercellular adhesion molecule 1	Homo sapiens	71-77
10092822-5	1999	L-selectin attachment to the cytoskeleton was not prevented by inhibitors of actin/microtubule polymerization (cytochalasin B, colchicine, or nocodozole) or serine/threonine and tyrosine kinase activity (staurosporine, calphostin C, or genistein), although L-selectin-mediated adhesion of human PBL was markedly suppressed by these agents.	calphostin C	219-231	selectin L	Homo sapiens	0-10
10087440-6	1999	Activation of protein kinase C (PKC) by phorbol-12-myristate-13-acetate (PMA) increased PLD activity that was effectively blocked by the PKC inhibitors calphostin C (10(-8) to 10(-6) M) and GFX (10(-8) to 10(-6) M).	calphostin C	152-164	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	88-91
10072259-7	1999	Preincubation of HUVECs with the PKC inhibitors bis-indolylmaleimide (BIN) or calphostin C or the TK inhibitors genistein or herbimycin A (HMA) blocked the TNF-alpha-induced increase in H82 cell attachment.	calphostin C	78-90	tumor necrosis factor	Homo sapiens	156-165
10051543-6	1999	However, both PKC activation and oxidant generation were necessary for ICAM-1 mRNA expression because the pretreatment of HPAE cells with either calphostin C or N-acetylcysteine inhibited the TNF-alpha-induced activation of NF-kappaB and prevented the activation of ICAM-1 promoter.	calphostin C	145-157	tumor necrosis factor	Homo sapiens	192-201
10051543-6	1999	However, both PKC activation and oxidant generation were necessary for ICAM-1 mRNA expression because the pretreatment of HPAE cells with either calphostin C or N-acetylcysteine inhibited the TNF-alpha-induced activation of NF-kappaB and prevented the activation of ICAM-1 promoter.	calphostin C	145-157	intercellular adhesion molecule 1	Homo sapiens	266-272
10026138-0	1999	Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is dispensable for cell death.	calphostin C	90-102	mitogen-activated protein kinase 14	Homo sapiens	76-79
10026138-0	1999	Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is dispensable for cell death.	calphostin C	90-102	caspase 3	Homo sapiens	130-139
10026138-1	1999	Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3 but not caspase-1.	calphostin C	71-83	BCL2 apoptosis regulator	Homo sapiens	209-214
10036321-6	1999	On the other hand, PKC selective inhibitor, calphostin C (0.2 microM) or chelerythrine (1.0 microM), aggravated the contractile dysfunction of ischemic heart during reperfusion, when they were perfused during reperfusion.	calphostin C	44-56	protein kinase C, gamma	Rattus norvegicus	19-22
10026138-1	1999	Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3 but not caspase-1.	calphostin C	71-83	BCL2 like 1	Homo sapiens	219-225
10026138-1	1999	Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3 but not caspase-1.	calphostin C	71-83	caspase 3	Homo sapiens	251-260
10026138-1	1999	Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3 but not caspase-1.	calphostin C	71-83	caspase 1	Homo sapiens	269-278
10026138-1	1999	Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3 but not caspase-1.	calphostin C	127-139	BCL2 apoptosis regulator	Homo sapiens	209-214
10026138-1	1999	Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3 but not caspase-1.	calphostin C	127-139	BCL2 like 1	Homo sapiens	219-225
10026138-1	1999	Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3 but not caspase-1.	calphostin C	127-139	caspase 3	Homo sapiens	251-260
10026138-1	1999	Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3 but not caspase-1.	calphostin C	127-139	caspase 1	Homo sapiens	269-278
10026138-2	1999	The exposure to calphostin C led to activation of stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) and p38 kinase and concurrent inhibition of extracellular signal-regulated kinase (ERK).	calphostin C	16-28	mitogen-activated protein kinase 14	Homo sapiens	123-126
10026138-2	1999	The exposure to calphostin C led to activation of stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) and p38 kinase and concurrent inhibition of extracellular signal-regulated kinase (ERK).	calphostin C	16-28	mitogen-activated protein kinase 1	Homo sapiens	163-200
10026138-2	1999	The exposure to calphostin C led to activation of stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) and p38 kinase and concurrent inhibition of extracellular signal-regulated kinase (ERK).	calphostin C	16-28	mitogen-activated protein kinase 1	Homo sapiens	202-205
10022508-4	1999	Calphostin C, a highly and potent inhibitor of protein kinase C, enhanced sphingomyelinase-induced IL-6 synthesis.	calphostin C	0-12	interleukin 6	Mus musculus	99-103
9925748-8	1999	Staurosporine and calphostin C, inhibitors of PKC, significantly reduced the vasopressin-induced accumulation of HSP27 and alphaB-crystallin as well as that induced by TPA.	calphostin C	18-30	proline rich transmembrane protein 2	Homo sapiens	46-49
9925748-8	1999	Staurosporine and calphostin C, inhibitors of PKC, significantly reduced the vasopressin-induced accumulation of HSP27 and alphaB-crystallin as well as that induced by TPA.	calphostin C	18-30	arginine vasopressin	Homo sapiens	77-88
9925748-8	1999	Staurosporine and calphostin C, inhibitors of PKC, significantly reduced the vasopressin-induced accumulation of HSP27 and alphaB-crystallin as well as that induced by TPA.	calphostin C	18-30	heat shock protein family B (small) member 1	Homo sapiens	113-118
9950863-6	1999	Strain-induced ERK1/ERK2 activation was partly inhibited by the protein kinase C inhibitor calphostin C and completely inhibited by the tyrosine kinase inhibitor genistein.	calphostin C	91-103	mitogen-activated protein kinase 3	Bos taurus	15-19
9950863-6	1999	Strain-induced ERK1/ERK2 activation was partly inhibited by the protein kinase C inhibitor calphostin C and completely inhibited by the tyrosine kinase inhibitor genistein.	calphostin C	91-103	mitogen-activated protein kinase 1	Bos taurus	20-24
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	calphostin C	233-245	protein kinase C zeta	Homo sapiens	51-54
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	calphostin C	233-245	insulin	Homo sapiens	101-108
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	calphostin C	233-245	pancreatic and duodenal homeobox 1	Homo sapiens	168-207
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	calphostin C	233-245	pancreatic and duodenal homeobox 1	Homo sapiens	209-214
10426567-6	1999	Furthermore, increased PDX-1 function induced by high glucose was blocked by calphostin C, an inhibitor of all PKC isoforms, but unaffected by phorbol 12-myristate 13-acetate (PMA), an activator of classical and novel PKC, or Go 6976, an inhibitor of classical and novel PKC, which suggested that the PKC family which activated PDX-1 in MIN6 cells was atypical PKC.	calphostin C	77-89	pancreatic and duodenal homeobox 1	Mus musculus	23-28
10426567-6	1999	Furthermore, increased PDX-1 function induced by high glucose was blocked by calphostin C, an inhibitor of all PKC isoforms, but unaffected by phorbol 12-myristate 13-acetate (PMA), an activator of classical and novel PKC, or Go 6976, an inhibitor of classical and novel PKC, which suggested that the PKC family which activated PDX-1 in MIN6 cells was atypical PKC.	calphostin C	77-89	protein kinase C zeta	Homo sapiens	111-114
9986738-12	1999	The down-regulation of IGF-I expression by bFGF (10 ng ml-1) and PMA (0.1 microM) was blocked by the PKC inhibitors H-7 (30 microM) and calphostin C (1 microM).	calphostin C	136-148	insulin-like growth factor 1	Rattus norvegicus	23-28
9932728-4	1999	Calphostin C partially inhibited the fMLP- and PMA-induced cPLA 2 activation, but had no influence on thapsigargin- and cyclopiazonic acid-treated cells.	calphostin C	0-12	formyl peptide receptor 1	Homo sapiens	37-41
9932728-4	1999	Calphostin C partially inhibited the fMLP- and PMA-induced cPLA 2 activation, but had no influence on thapsigargin- and cyclopiazonic acid-treated cells.	calphostin C	0-12	phospholipase A2 group IVA	Homo sapiens	59-65
10668444-10	1999	Calphostin C (0.5 microM), a specific PKC inhibitor, applied intracellularly via recording patch pipette, completely abolished MS-153 suppression of the calcium channel current.	calphostin C	0-12	protein kinase C, gamma	Rattus norvegicus	38-41
9986738-12	1999	The down-regulation of IGF-I expression by bFGF (10 ng ml-1) and PMA (0.1 microM) was blocked by the PKC inhibitors H-7 (30 microM) and calphostin C (1 microM).	calphostin C	136-148	fibroblast growth factor 2	Rattus norvegicus	43-47
10604280-4	1999	Pretreatment with 1 microM calphostin C or 20 nM staurosporine caused marked reductions in contractions induced by ET-1 and U46619 in both control and diabetic aortas, and the difference in the maximum contractile responses to these agonists between control and diabetic aortas were eliminated by their treatment.	calphostin C	27-39	endothelin 1	Rattus norvegicus	115-119
9882706-4	1999	Similarly, either calphostin C, an inhibitor of protein kinase C, or U73122, an inhibitor of phospholipase C, partially inhibited the S1Pinduced ERK1/2 activation in the nontreated cells with PTX and completely in the toxin-treated cells.	calphostin C	18-30	mitogen-activated protein kinase 3	Homo sapiens	145-151
9855633-9	1998	On the other hand, N6,2"-O-dibutyryl cAMP or calphostin C induced a decreased Bcl-2 level and enhanced MPP+-induced cell death.	calphostin C	45-57	BCL2 apoptosis regulator	Homo sapiens	78-83
10458519-8	1999	Similarly, staurosporine (10(-7) mol/l) and calphostin C (10(-6) mol/l), inhibitors of protein kinase C (PKC), diminished basal tone and abolished the ANP-response in HR thoracic aorta.	calphostin C	44-56	natriuretic peptide A	Rattus norvegicus	151-154
9860239-6	1998	We found that ECP release induced by SOS was inhibited by the PKC inhibitors staurosporine and calphostin C.	calphostin C	95-107	ribonuclease A family member 3	Homo sapiens	14-17
9792719-7	1998	Activation of PLD by H2O2 was also inhibited dose-dependently by the PKC inhibitors Ro 31-8220 and calphostin C.	calphostin C	99-111	protein kinase C, alpha	Rattus norvegicus	69-72
9860239-6	1998	We found that ECP release induced by SOS was inhibited by the PKC inhibitors staurosporine and calphostin C.	calphostin C	95-107	proline rich transmembrane protein 2	Homo sapiens	62-65
9824485-3	1998	We performed an analysis of the mechanisms by which two PKC inhibitors, Calphostin C and Staurosporine, prevent the FN-induced IL-1beta response.	calphostin C	72-84	interleukin 1 beta	Homo sapiens	127-135
9820166-5	1998	The thrombin-enhanced PCA depended on the activation of protein kinase C (PKC) as it was diminished by staurosporine and calphostin C.	calphostin C	121-133	coagulation factor II, thrombin	Homo sapiens	4-12
9794429-3	1998	The Ag-induced JNK activation was inhibited by the phosphatidylinositol 3-kinase inhibitors wortmannin (10-100 nM) and LY 294002 (100 microM) but not by the protein kinase C inhibitors calphostin C (1 and 3 microM) and Ro 31-8425 (1 and 3 microM).	calphostin C	185-197	mitogen-activated protein kinase 8	Rattus norvegicus	15-18
9855300-4	1998	The protein kinase C (PKC) inhibitors chelerythrine (0.5 and 2 microM), calphostin C (1 microM) and staurospine (10 nM) significantly inhibited the microglial chemotaxis induced by Abeta (25-35) (1 nM).	calphostin C	72-84	proline rich transmembrane protein 2	Homo sapiens	4-20
9855300-4	1998	The protein kinase C (PKC) inhibitors chelerythrine (0.5 and 2 microM), calphostin C (1 microM) and staurospine (10 nM) significantly inhibited the microglial chemotaxis induced by Abeta (25-35) (1 nM).	calphostin C	72-84	proline rich transmembrane protein 2	Homo sapiens	22-25
9855300-4	1998	The protein kinase C (PKC) inhibitors chelerythrine (0.5 and 2 microM), calphostin C (1 microM) and staurospine (10 nM) significantly inhibited the microglial chemotaxis induced by Abeta (25-35) (1 nM).	calphostin C	72-84	amyloid beta precursor protein	Homo sapiens	181-186
9755111-7	1998	Furthermore, protection by KGF was completely blocked by 1) genistein, a tyrosine kinase inhibitor; 2) staurosporine and calphostin C, protein kinase C (PKC) inhibitors; and 3) aphidicolin, butylphenyl dGTP, and 2",3"-dideoxythymidine 5"-triphosphate, inhibitors of DNA polymerase.	calphostin C	121-133	fibroblast growth factor 7	Rattus norvegicus	27-30
9764845-5	1998	Calphostin C, a potent protein kinase C inhibitor, significantly reduced cholecalciferol-induced PGE2 production by inhibiting cholecalciferol-enhanced COX-2 mRNA and protein expression.	calphostin C	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
9765341-6	1998	In contrast, chelation of intracellular calcium with BAPTA-AM attenuated, increasing intracellular calcium with A23187 augmented, and inhibition of protein kinase C with either calphostin C or chelerythrine chloride abolished Ang II enhancement of isoproterenol-induced cAMP.	calphostin C	177-189	angiotensinogen	Rattus norvegicus	226-232
9755245-7	1998	In addition, PKC inhibition by chelerythrine and calphostin C (500 nmol/L) prevented cell volume recovery from swelling.	calphostin C	49-61	proline rich transmembrane protein 2	Homo sapiens	13-16
9744958-11	1998	The specific protein kinase C inhibitors, chelerythrine (20 microM) and calphostin C (10 microM), blocked the effect of PMA on INaP.	calphostin C	72-84	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta	Mus musculus	127-131
9692365-14	1998	To investigate the signal transduction pathways through which KGF mediates protection, permeability was measured in the presence of the protein kinase C (PKC) inhibitor, calphostin C, or the tyrosine kinase inhibitor, genistein.	calphostin C	170-182	fibroblast growth factor 7	Homo sapiens	62-65
9688598-5	1998	Two broad protein kinase C (PKC) kinase inhibitors, staurosporine and calphostin C, also abolished the NPY-induced decrease in CBF.	calphostin C	70-82	neuropeptide Y	Homo sapiens	103-106
9671211-6	1998	Activation of PK-A was dependent on a Tat-induced increase in membrane PK-C activity as demonstrated by calphostin C (a PK-C inhibitor) abolishing this effect.	calphostin C	104-116	tyrosine aminotransferase	Homo sapiens	38-41
9617483-3	1998	Heat-induced Hsp72 accumulation was also suppressed by staurosporine (a potent inhibitor of PKC and PKA) or calphostin C [(CAL) a potent inhibitor of PKC] at high concentration (10 x IC50) but not at low concentration (1 x IC50).	calphostin C	108-120	heat shock protein family A (Hsp70) member 1A	Homo sapiens	13-18
9648724-7	1998	Inhibition of protein kinase C by either calphostin C or phorbol 12-myristate 13-acetate downregulation inhibited the Ang II-induced tyrosine phosphorylation of p130Cas.	calphostin C	41-53	angiotensinogen	Homo sapiens	118-124
9648724-7	1998	Inhibition of protein kinase C by either calphostin C or phorbol 12-myristate 13-acetate downregulation inhibited the Ang II-induced tyrosine phosphorylation of p130Cas.	calphostin C	41-53	BCAR1 scaffold protein, Cas family member	Homo sapiens	161-168
9614207-7	1998	This PLC-beta3 phosphorylation was mainly due to PKC activation because pretreatment of NG108-15 cells with calphostin C could block the DPDPE effect.	calphostin C	108-120	phospholipase C, beta 3	Mus musculus	5-14
9648920-4	1998	Down-regulation of PKC-isoforms by 12-O-tetradecanoylphorbol-13-acetate or pretreatment with the PKC inhibitor calphostin C, completely blocked PDGF action on GJC and Cx43.	calphostin C	111-123	gap junction protein alpha 1	Homo sapiens	167-171
9573531-7	1998	The increased AP-1 binding was partly reversed by treatment of HMC with Calphostin C or Bisindolylmaleimide I suggesting a partial role of the protein kinase C (PKC) pathway in mediating AP-1 binding.	calphostin C	72-84	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18
9573531-7	1998	The increased AP-1 binding was partly reversed by treatment of HMC with Calphostin C or Bisindolylmaleimide I suggesting a partial role of the protein kinase C (PKC) pathway in mediating AP-1 binding.	calphostin C	72-84	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	187-191
9617483-3	1998	Heat-induced Hsp72 accumulation was also suppressed by staurosporine (a potent inhibitor of PKC and PKA) or calphostin C [(CAL) a potent inhibitor of PKC] at high concentration (10 x IC50) but not at low concentration (1 x IC50).	calphostin C	108-120	filamin binding LIM protein 1	Homo sapiens	123-126
9617483-3	1998	Heat-induced Hsp72 accumulation was also suppressed by staurosporine (a potent inhibitor of PKC and PKA) or calphostin C [(CAL) a potent inhibitor of PKC] at high concentration (10 x IC50) but not at low concentration (1 x IC50).	calphostin C	108-120	proline rich transmembrane protein 2	Homo sapiens	150-153
9442092-7	1998	Bile acid-mediated induction of COX-2 was blocked by inhibitors of PKC activity, including calphostin C and staurosporine.	calphostin C	91-103	prostaglandin-endoperoxide synthase 2	Homo sapiens	32-37
9556135-10	1998	Calphostin C, a specific inhibitor of protein kinase C (PKC), enhanced the secretion of IL-6 induced by PGE2.	calphostin C	0-12	interleukin 6	Mus musculus	88-92
9555020-8	1998	Inhibition of protein kinase C (PKC) by the potent and selective PKC inhibitor calphostin C converted the inhibitory action of PDGF into a bFGF-type of response thus suggesting that PKC is a major effector in PDGF-induced inhibition of IL-1beta-stimulated group II sPLA2 expression.	calphostin C	79-91	fibroblast growth factor 2	Rattus norvegicus	139-143
9555020-8	1998	Inhibition of protein kinase C (PKC) by the potent and selective PKC inhibitor calphostin C converted the inhibitory action of PDGF into a bFGF-type of response thus suggesting that PKC is a major effector in PDGF-induced inhibition of IL-1beta-stimulated group II sPLA2 expression.	calphostin C	79-91	interleukin 1 beta	Rattus norvegicus	236-244
9555020-8	1998	Inhibition of protein kinase C (PKC) by the potent and selective PKC inhibitor calphostin C converted the inhibitory action of PDGF into a bFGF-type of response thus suggesting that PKC is a major effector in PDGF-induced inhibition of IL-1beta-stimulated group II sPLA2 expression.	calphostin C	79-91	phospholipase A2 group IIA	Rattus norvegicus	265-270
9500973-4	1998	The upregulation of NF-kappa B activity was abrogated by calphostin C, an inhibitor of protein kinase C. Cell adhesion determined a strong reduction in the cytoplasmic levels of the NF-kappa B inhibitor I kappa B alpha, reduction that was prevented after treatment with calphostin C, suggesting that PKC-dependent I kappa B alpha phosphorylation might be involved in the upregulation of NF-kappa B.	calphostin C	57-69	nuclear factor kappa B subunit 1	Homo sapiens	20-30
9500973-4	1998	The upregulation of NF-kappa B activity was abrogated by calphostin C, an inhibitor of protein kinase C. Cell adhesion determined a strong reduction in the cytoplasmic levels of the NF-kappa B inhibitor I kappa B alpha, reduction that was prevented after treatment with calphostin C, suggesting that PKC-dependent I kappa B alpha phosphorylation might be involved in the upregulation of NF-kappa B.	calphostin C	57-69	nuclear factor kappa B subunit 1	Homo sapiens	182-192
9500973-4	1998	The upregulation of NF-kappa B activity was abrogated by calphostin C, an inhibitor of protein kinase C. Cell adhesion determined a strong reduction in the cytoplasmic levels of the NF-kappa B inhibitor I kappa B alpha, reduction that was prevented after treatment with calphostin C, suggesting that PKC-dependent I kappa B alpha phosphorylation might be involved in the upregulation of NF-kappa B.	calphostin C	57-69	NFKB inhibitor alpha	Homo sapiens	203-218
9500973-4	1998	The upregulation of NF-kappa B activity was abrogated by calphostin C, an inhibitor of protein kinase C. Cell adhesion determined a strong reduction in the cytoplasmic levels of the NF-kappa B inhibitor I kappa B alpha, reduction that was prevented after treatment with calphostin C, suggesting that PKC-dependent I kappa B alpha phosphorylation might be involved in the upregulation of NF-kappa B.	calphostin C	57-69	NFKB inhibitor alpha	Homo sapiens	314-329
9500973-4	1998	The upregulation of NF-kappa B activity was abrogated by calphostin C, an inhibitor of protein kinase C. Cell adhesion determined a strong reduction in the cytoplasmic levels of the NF-kappa B inhibitor I kappa B alpha, reduction that was prevented after treatment with calphostin C, suggesting that PKC-dependent I kappa B alpha phosphorylation might be involved in the upregulation of NF-kappa B.	calphostin C	57-69	nuclear factor kappa B subunit 1	Homo sapiens	182-192
9666341-14	1998	cAMP-stimulated testosterone production and P450c17 mRNA expression were significantly inhibited by 10 nM AVP (p < 0.05), and this inhibition was reversed by treatment with Calphostin C.	calphostin C	176-188	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	44-51
9536123-8	1998	Both PKC depletion by treatment with phorbol 12-myristate 13-acetate (PMA) for 18 hr and PKC inhibition by Calphostin C rendered macrophages more permissive for the intracellular GBS survival.	calphostin C	107-119	guanine nucleotide binding protein (G protein), beta 5	Mus musculus	179-182
9448055-6	1998	The actions of Bis I on PAF-stimulated thromboxane and leukotriene production were mimicked by a second PKC inhibitor, calphostin C, whereas the non-PKC-inhibitory analog, bisindolylmaleimide V, caused no enhancement of TxB2 or LTC4 production.	calphostin C	119-131	proline rich transmembrane protein 2	Homo sapiens	104-107
9458713-8	1998	The effect of TNF-alpha on myo-inositol accumulation was also partially prevented by the protein kinase C inhibitor calphostin C but not by staurosporine.	calphostin C	116-128	tumor necrosis factor	Bos taurus	14-23
9392454-7	1997	TCDD-induced CYP1A1 expression in cultured rat thymocytes was inhibited by the addition of calphostin C, a specific protein kinase C (PKC) inhibitor, suggesting a role for PKC as a second messenger in the CYP1A1 induction pathway.	calphostin C	91-103	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	13-19
9436787-5	1998	Similarly, the phorbol ester-enhanced process extension and increased MMP-9 activity were both inhibited by calphostin C, a selective PKC inhibitor.	calphostin C	108-120	matrix metallopeptidase 9	Homo sapiens	70-75
9609459-4	1998	Semiquantitative PCR showed that phorbol myristate acetate (100 nM) increased the ratio of PCR products for MCP-1 to housekeeping gene glyceraldehyde-3-phosphate dehydrogenase on densitometric results at 24 h by 2.7-fold, which was prevented by calphostin C (200 nM) pretreatment.	calphostin C	245-257	C-C motif chemokine ligand 2	Homo sapiens	108-113
9609459-4	1998	Semiquantitative PCR showed that phorbol myristate acetate (100 nM) increased the ratio of PCR products for MCP-1 to housekeeping gene glyceraldehyde-3-phosphate dehydrogenase on densitometric results at 24 h by 2.7-fold, which was prevented by calphostin C (200 nM) pretreatment.	calphostin C	245-257	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	135-175
9870716-0	1998	Calphostin C induces expression of amphiregulin mRNA via reactive oxygen species in IEC-6 cells.	calphostin C	0-12	amphiregulin	Rattus norvegicus	35-47
9870716-1	1998	Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, is generally used as a specific inhibitor of protein kinase C. It is known that 12-O-tetradecanoyl-13-phorbol acetate (TPA), a protein kinase C activator, induces expression of mRNA for amphiregulin (AR), a member of EGF-related polypeptides, in mammalian epithelial cells.	calphostin C	0-12	amphiregulin	Homo sapiens	267-279
9870716-1	1998	Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, is generally used as a specific inhibitor of protein kinase C. It is known that 12-O-tetradecanoyl-13-phorbol acetate (TPA), a protein kinase C activator, induces expression of mRNA for amphiregulin (AR), a member of EGF-related polypeptides, in mammalian epithelial cells.	calphostin C	0-12	amphiregulin	Homo sapiens	281-283
9392454-7	1997	TCDD-induced CYP1A1 expression in cultured rat thymocytes was inhibited by the addition of calphostin C, a specific protein kinase C (PKC) inhibitor, suggesting a role for PKC as a second messenger in the CYP1A1 induction pathway.	calphostin C	91-103	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	205-211
9400375-5	1997	The high glucose-induced impairment of insulin-mediated [3H]deoxyglucose uptake was blocked by a protein kinase C (PKC) inhibitor (calphostin C, 1 mumol/L) and was also improved by troglitazone without any change in insulin receptor number and affinity.	calphostin C	131-143	insulin receptor	Oryctolagus cuniculus	216-232
9427323-1	1997	Activation of PKC with 12-tetra-decanoylphorbol-13-acetate (TPA) or inhibition with staurosporine or calphostin C down-regulated GnRH mRNA levels.	calphostin C	101-113	gonadotropin releasing hormone 1	Mus musculus	129-133
9361188-8	1997	PKC inhibitors, calphostin C (10 nM), and staurosporine (5 nM), inhibited strain-induced PKC activation and keratinocyte proliferation, but did not block the effects of strain on cellular morphology or alignment.	calphostin C	16-28	protein kinase C alpha	Homo sapiens	89-92
9417875-9	1997	In contrast, both calphostin C and bisindolylmaleimide, specific inhibitors of protein kinase C, consistently increased by 30-50% the ratio of nuclear-bound/total amount of the cyclin protein.	calphostin C	18-30	proliferating cell nuclear antigen	Homo sapiens	177-183
9395784-9	1997	Tumour necrosis factor alpha (TNF-alpha)-induced membrane expression of PR-3 could be blocked with the RNA synthesis inhibitor actinomycin D, the protein kinase C (PKC) and proteinase A (PKA) inhibitor staurosporine, the specific PKA inhibitor calphostin C, the c-AMP-dependent PKA inhibitor KT5720 and the tyrosine kinase inhibitor genistein in a dose-dependent manner.	calphostin C	244-256	tumor necrosis factor	Homo sapiens	30-39
9409288-6	1997	On the other hand, phospholipase A2-treated acetylated LDL did not induce a rise in calcium but significantly activated PKC and led to significant macrophage growth that was significantly inhibited by calphostin C by 90%.	calphostin C	201-213	phospholipase A2 group IB	Homo sapiens	19-35
9395784-9	1997	Tumour necrosis factor alpha (TNF-alpha)-induced membrane expression of PR-3 could be blocked with the RNA synthesis inhibitor actinomycin D, the protein kinase C (PKC) and proteinase A (PKA) inhibitor staurosporine, the specific PKA inhibitor calphostin C, the c-AMP-dependent PKA inhibitor KT5720 and the tyrosine kinase inhibitor genistein in a dose-dependent manner.	calphostin C	244-256	proteinase 3	Homo sapiens	72-76
9352311-21	1997	Calphostin C (1 microM), a specific protein kinase C (PKC) inhibitor, reduced the maximum contractile response to ET-1 by about 50% without significantly affecting its pD2 value.	calphostin C	0-12	endothelin 1	Bos taurus	114-118
9335453-7	1997	Moreover, a protein kinase C-dependent role in alpha4beta1 activity was suggested by adhesion assays carried out in the presence of the protein kinase C inhibitor calphostin C, which considerably reduced adhesion to CS-1 peptide.	calphostin C	163-175	myozenin 2	Homo sapiens	216-220
9312119-2	1997	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), significantly enhanced the TNF-induced synthesis of IL-6.	calphostin C	18-30	tumor necrosis factor	Mus musculus	97-100
9312119-2	1997	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), significantly enhanced the TNF-induced synthesis of IL-6.	calphostin C	18-30	interleukin 6	Mus musculus	122-126
9393984-3	1997	Exposure of cells with v-Abl PTK active to the PKC inhbitor calphostin C (125 ng/ml) prevented the increase in Bcl-xL protein and resulted in apoptosis.	calphostin C	60-72	BCL2-like 1	Mus musculus	111-117
9343304-6	1997	Pretreatment of conceptuses with 1 microM PMA for 12 h to produce PKC-deficient tissues or treatment with 50 mM calphostin C abolished the hGM-CSF-induced increase in oIFNtau mRNA.	calphostin C	112-124	colony stimulating factor 2	Homo sapiens	139-146
9315663-7	1997	Notably, the lack of pRB in these U937-derived clones renders these p53-null cells highly resistant to apoptosis induced by serum withdrawal, calphostin C, and ceramide.	calphostin C	142-154	RB transcriptional corepressor 1	Homo sapiens	21-24
9315663-7	1997	Notably, the lack of pRB in these U937-derived clones renders these p53-null cells highly resistant to apoptosis induced by serum withdrawal, calphostin C, and ceramide.	calphostin C	142-154	tumor protein p53	Homo sapiens	68-71
9328844-2	1997	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), significantly enhanced the IL-1-induced secretion of IL-6.	calphostin C	18-30	interleukin 1 complex	Mus musculus	97-101
9295313-7	1997	The effect of glucose on IGF-II binding was mimicked by fructose (10 mM), but not by 3-O-methylglucose (10 mM), and was abolished by the protein kinase C (PKC) inhibitor calphostin C, or down-regulation of PKC, but not by the protein phosphatase inhibitor, okadaic acid.	calphostin C	170-182	insulin like growth factor 2	Homo sapiens	25-31
9328844-2	1997	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), significantly enhanced the IL-1-induced secretion of IL-6.	calphostin C	18-30	interleukin 6	Mus musculus	123-127
9379406-8	1997	Pretreatment with the PKC inhibitors staurosporine (100 nM) or calphostin C (500 nM) prevented the Ang II-induced inhibition of IK,ATP.	calphostin C	63-75	angiotensinogen	Rattus norvegicus	99-105
9252561-6	1997	SMC from fetuses and hypoxic calves were more susceptible to the growth-inhibiting effects of PKC antagonists (dihydrosphingosine and calphostin C) than control neonatal and adult cells.	calphostin C	134-146	protein kinase C alpha	Bos taurus	94-97
9368670-0	1997	Calphostin C synergistically induces apoptosis with VP-16 in lymphoma cells which express abundant phosphorylated Bcl-2 protein.	calphostin C	0-12	host cell factor C1	Homo sapiens	52-57
9368670-0	1997	Calphostin C synergistically induces apoptosis with VP-16 in lymphoma cells which express abundant phosphorylated Bcl-2 protein.	calphostin C	0-12	BCL2 apoptosis regulator	Homo sapiens	114-119
9368670-3	1997	However, coincubation with calphostin C (0.2 microgram/mL), a protein kinase C (PKC) inhibitor, induced DNA fragmentation in VP-16-treated OZ cells (13.5% of total DNA) at 6 h after the treatment.	calphostin C	27-39	host cell factor C1	Homo sapiens	125-130
9275066-6	1997	However, when HTC-TSHr cells were pretreated with calphostin C or staurosporine, inhibitors of protein kinase C, a TSH concentration of 20 mU/ml enhanced generation of inositol phosphates in these cells.	calphostin C	50-62	thyroid stimulating hormone receptor	Homo sapiens	18-22
9242432-9	1997	Quantitation of Northern blots showed that fiber-associated c-fos/c-jun mRNA levels were significantly lower either after PKC alpha down-modulation or pretreatment with calphostin C.	calphostin C	169-181	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-65
9291832-4	1997	The PKC inhibitors, calphostin C, staurosporine and chelerythrine, partially reduced GH release in response to GRF and GHRP-2 at doses which selectively inhibit PKC activity.	calphostin C	20-32	somatoliberin	Ovis aries	111-114
9211886-8	1997	On the other hand, genistein, tyrphostin-25 (inhibitors of tyrosine-specific protein kinase), and calphostin C (an inhibitor of protein kinase C) block the activation of PAF:acyllyso-GPC transacetylase by ATP.	calphostin C	98-110	PCNA-associated factor	Bos taurus	170-173
9211886-8	1997	On the other hand, genistein, tyrphostin-25 (inhibitors of tyrosine-specific protein kinase), and calphostin C (an inhibitor of protein kinase C) block the activation of PAF:acyllyso-GPC transacetylase by ATP.	calphostin C	98-110	glycophorin C	Bos taurus	183-186
9083268-6	1997	The effects of insulin also were inhibited by staurosporin and calphostin C, which are dissimilar inhibitors of PKC.	calphostin C	63-75	insulin	Homo sapiens	15-22
9169347-7	1997	In contrast, staurosporine and calphostin C, inhibitors of PKC, suppressed IL-1-stimulated, but not PTH-stimulated, IL-6/ IL-11 production.	calphostin C	31-43	interleukin 1 alpha	Homo sapiens	75-79
9169347-7	1997	In contrast, staurosporine and calphostin C, inhibitors of PKC, suppressed IL-1-stimulated, but not PTH-stimulated, IL-6/ IL-11 production.	calphostin C	31-43	interleukin 11	Homo sapiens	122-127
9133554-5	1997	Furthermore, the activities of cPLA2 also increased in cells cultured under the same conditions and this activation was inhibited by both calphostin C and PD 098059, an inhibitor of MEK (MAPK or extracellular signal-regulated kinase [ERK] kinase).	calphostin C	138-150	phospholipase A2 group IVA	Rattus norvegicus	31-36
9133554-5	1997	Furthermore, the activities of cPLA2 also increased in cells cultured under the same conditions and this activation was inhibited by both calphostin C and PD 098059, an inhibitor of MEK (MAPK or extracellular signal-regulated kinase [ERK] kinase).	calphostin C	138-150	Eph receptor B1	Rattus norvegicus	195-232
9133554-5	1997	Furthermore, the activities of cPLA2 also increased in cells cultured under the same conditions and this activation was inhibited by both calphostin C and PD 098059, an inhibitor of MEK (MAPK or extracellular signal-regulated kinase [ERK] kinase).	calphostin C	138-150	Eph receptor B1	Rattus norvegicus	234-237
9175844-7	1997	All Cd2+ induced changes in Ca2+ homeostasis were obliterated by concurrent treatment with 0.1 microM calphostin C (CC), a potent protein kinase C (PKC) inhibitor.	calphostin C	102-114	Cd2 molecule	Rattus norvegicus	4-7
9101406-9	1997	The inhibition of GIRK activity by mGluR1a was suppressed by a broad-specificity protein kinase inhibitor, staurosporine, and by a specific protein kinase C (PKC) inhibitor, bis-indolylmaleimide, but not by PTX, Ca(2-)chelation, or calphostin C.	calphostin C	232-244	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	18-22
9207924-6	1997	The increase in PKC activity, HSP70-spectrin-PKC aggregate formation, and heat shock protein expression resulting from exposure to fever-like hyperthermia are all inhibited by calphostin C, a specific inhibitor of PKC.	calphostin C	176-188	proline rich transmembrane protein 2	Homo sapiens	16-19
9207924-6	1997	The increase in PKC activity, HSP70-spectrin-PKC aggregate formation, and heat shock protein expression resulting from exposure to fever-like hyperthermia are all inhibited by calphostin C, a specific inhibitor of PKC.	calphostin C	176-188	heat shock protein family A (Hsp70) member 4	Homo sapiens	30-35
9207924-6	1997	The increase in PKC activity, HSP70-spectrin-PKC aggregate formation, and heat shock protein expression resulting from exposure to fever-like hyperthermia are all inhibited by calphostin C, a specific inhibitor of PKC.	calphostin C	176-188	proline rich transmembrane protein 2	Homo sapiens	45-48
9207924-6	1997	The increase in PKC activity, HSP70-spectrin-PKC aggregate formation, and heat shock protein expression resulting from exposure to fever-like hyperthermia are all inhibited by calphostin C, a specific inhibitor of PKC.	calphostin C	176-188	proline rich transmembrane protein 2	Homo sapiens	45-48
9169462-12	1997	Specific protein kinase C inhibitors (bisindolylmaleimide (GF109203X) and calphostin C) blocked the activation of NF-kappaB by each compound.	calphostin C	74-86	nuclear factor kappa B subunit 1	Homo sapiens	114-123
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	calphostin C	181-193	interleukin 1 beta	Homo sapiens	4-13
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	calphostin C	181-193	plasminogen activator, urokinase receptor	Homo sapiens	35-40
9227606-7	1997	However, pHi acidification stimulated protein kinase C (PKC) activity and inhibition of PKC by PKC inhibitors (bisindolylmaleimide, calphostin C, or staurosporine) or prolonged exposure to phorbol ester abrogated the inhibitory effect of pHi acidification on cell Pi uptake.	calphostin C	132-144	glucose-6-phosphate isomerase	Homo sapiens	9-12
9112402-9	1997	Calphostin C, a protein kinase C inhibitor, attenuated the effect of insulin and IGF-I, whereas wortmannin, a phosphatidylinositol 3-kinase inhibitor, was ineffective.	calphostin C	0-12	insulin-like growth factor 1	Rattus norvegicus	81-86
9225570-7	1997	Since calphostin C, a selective inhibitor of protein kinase C, lowered increased NHE in vitro, the protein kinase C-dependent pathway of the exchanger regulation was concluded to be responsible for NHE activation in diabetes mellitus and essential hypertension.	calphostin C	6-18	solute carrier family 9 member C1	Homo sapiens	81-84
9225570-7	1997	Since calphostin C, a selective inhibitor of protein kinase C, lowered increased NHE in vitro, the protein kinase C-dependent pathway of the exchanger regulation was concluded to be responsible for NHE activation in diabetes mellitus and essential hypertension.	calphostin C	6-18	solute carrier family 9 member C1	Homo sapiens	198-201
9144344-9	1997	However 100 nM calphostin C, a PKC inhibitor, blunted this effect of PTHrP(107-139).	calphostin C	15-27	parathyroid hormone like hormone	Homo sapiens	69-74
9138081-6	1997	In addition to PKA-mediated decapsulation, inhibition of PKC by calphostin C alone was enough to induce decapsulation, a process that was independent of PKA activity, whereas activation of PKC could prevent Bt2cAMP-induced decapsulation.	calphostin C	64-76	protein kinase C, gamma	Rattus norvegicus	57-60
9083268-6	1997	The effects of insulin also were inhibited by staurosporin and calphostin C, which are dissimilar inhibitors of PKC.	calphostin C	63-75	proline rich transmembrane protein 2	Homo sapiens	112-115
9045700-4	1997	Both chelerythrine and calphostin C, two PKC inhibitors, abolished the stimulatory effect of the diglyceride and significantly reduced prodynorphin gene expression in cardiomyopathic myocytes.	calphostin C	23-35	proenkephalin-B	Mesocricetus auratus	135-147
9096366-5	1997	IL-10 protein production induced by Nef is inhibited by the calcium/calmodulin phosphodiesterase inhibitor W-7 but not by the protein kinase A inhibitor H-89 nor the protein kinase C inhibitors staurosporine and calphostin C.	calphostin C	212-224	interleukin 10	Homo sapiens	0-5
9045700-5	1997	Nuclear run-off experiments indicated that the prodynorphin gene was regulated at the transcriptional level and that treatment of nuclei isolated from control cells with 1, 2-dioctanoyl-sn-glycerol increased prodynorphin gene transcription, whereas chelerythrine or calphostin C abolished this transcriptional effect.	calphostin C	266-278	proenkephalin-B	Mesocricetus auratus	47-59
9124324-8	1997	Calphostin C, a highly specific PKC inhibitor, also suppressed the PGF2alpha-stimulated synthesis of IL-6.	calphostin C	0-12	interleukin 6	Mus musculus	101-105
9134219-10	1997	Among the other protein kinase inhibitors tested, only calphostin C also enhanced the stimulant effect of IL-1 beta approximately two fold, while genistein, erbstatin A and Ro 31-8220 inhibited rather than potentiated it.	calphostin C	55-67	interleukin 1 beta	Rattus norvegicus	106-115
9073607-9	1997	Pretreatment (24 hr) with 0.1 microM calphostin C (CC), a PKC inhibitor, produced no change in [Ca2+]i and prevented any rise in [Ca2+]i in response to Cd2+.	calphostin C	37-49	Cd2 molecule	Rattus norvegicus	152-155
9057076-9	1997	The inhibitory effect of angiotensin II was blocked by the AT1-receptor antagonist, losartan, and the protein kinase C inhibitor, calphostin C (50 nM).	calphostin C	130-142	angiotensinogen	Rattus norvegicus	25-39
9015316-14	1997	Increased levels of alpha2 and MMP-1 mRNA in collagen gel-stimulated fibroblasts were abrogated by bisindolylmaleimide GF 109203X and calphostin C, chemical inhibitors for PKC, but retained when cells were depleted of 12-myristate 13-acetate (PMA)-inducible PKC isoforms by 24 h of pretreatment with phorbol PMA.	calphostin C	134-146	matrix metallopeptidase 1	Homo sapiens	31-36
9015316-14	1997	Increased levels of alpha2 and MMP-1 mRNA in collagen gel-stimulated fibroblasts were abrogated by bisindolylmaleimide GF 109203X and calphostin C, chemical inhibitors for PKC, but retained when cells were depleted of 12-myristate 13-acetate (PMA)-inducible PKC isoforms by 24 h of pretreatment with phorbol PMA.	calphostin C	134-146	protein kinase C zeta	Homo sapiens	172-175
8896608-9	1996	The enhanced spreading induced by TS1 and 4N1K and the constitutive spreading on higher density VN are both blocked by calphostin C (100 nM), wortmannin (10 nM), and tyrosine kinase inhibitors.	calphostin C	119-131	thrombospondin 1	Homo sapiens	34-37
8973580-1	1996	Constitutive secretion of heparan sulphate proteoglycans (HSPGs) was stimulated in human hepatoma HepG2 cells by phorbol 12-myristate 13-acetate (PMA) and inhibited by calphostin C, a specific inhibitor of protein kinase C (PKC).	calphostin C	168-180	proline rich transmembrane protein 2	Homo sapiens	206-222
8973580-1	1996	Constitutive secretion of heparan sulphate proteoglycans (HSPGs) was stimulated in human hepatoma HepG2 cells by phorbol 12-myristate 13-acetate (PMA) and inhibited by calphostin C, a specific inhibitor of protein kinase C (PKC).	calphostin C	168-180	proline rich transmembrane protein 2	Homo sapiens	224-227
8940366-3	1996	Also, inhibitors of protein kinase C, staurosporine and calphostin C, reduced the AVP-induced increase in phosphatidylethanol.	calphostin C	56-68	arginine vasopressin	Rattus norvegicus	82-85
9237235-5	1996	The inclusion of the PKC inhibitors chelerythrine chloride or calphostin C reduced the observed phosphorylation in a concentration-dependent manner.	calphostin C	62-74	proline rich transmembrane protein 2	Homo sapiens	21-24
9547577-6	1997	12(S)-HETE-enhanced vimentin phosphorylation was abolished by protein kinase C (PKC) inhibitor calphostin C, thus suggesting the involvement of PKC.	calphostin C	95-107	vimentin	Mus musculus	20-28
9028636-4	1997	Calphostin C, a specific inhibitor of protein kinase C (PKC), completely blocked the ST action of DA on NKA, whereas IP20, a specific inhibitor of protein kinase (PKA), had no effect.	calphostin C	0-12	tachykinin precursor 1	Homo sapiens	104-107
8996200-8	1997	Calphostin C, a specific PKC inhibitor, and certain specific tyrosine kinase inhibitors, such as genistein and herbimycin A, abrogated the enhancing effects of TPA on IL-3-dependent colony formation.	calphostin C	0-12	interleukin 3	Mus musculus	167-171
8945687-13	1996	The highest concentration of calphostin C (800 nM) resulted in almost a complete inhibition of cytosolic (100%) and particulate (85%) PKC activity correlated with the abolition of preconditioning-induced cardiac protection.	calphostin C	29-41	protein kinase C, gamma	Rattus norvegicus	134-137
8906209-6	1996	TNF alpha-induced ICAM-1 expression also was inhibited by pre- and coincubation of TNF alpha with 3 micrograms/mL soluble TNF-R1 or by the PKC inhibitor, Calphostin C (0.1 and 0.5 microM).	calphostin C	154-166	tumor necrosis factor	Homo sapiens	0-9
8906209-6	1996	TNF alpha-induced ICAM-1 expression also was inhibited by pre- and coincubation of TNF alpha with 3 micrograms/mL soluble TNF-R1 or by the PKC inhibitor, Calphostin C (0.1 and 0.5 microM).	calphostin C	154-166	intercellular adhesion molecule 1	Homo sapiens	18-24
8906209-6	1996	TNF alpha-induced ICAM-1 expression also was inhibited by pre- and coincubation of TNF alpha with 3 micrograms/mL soluble TNF-R1 or by the PKC inhibitor, Calphostin C (0.1 and 0.5 microM).	calphostin C	154-166	tumor necrosis factor	Homo sapiens	0-3
8908158-5	1996	Staurosporine and calphostin C, protein kinase C (PKC) inhibitors, blocked the increased in sphingosine kinase activity, suggesting a PKC-dependent regulation.	calphostin C	18-30	proline rich transmembrane protein 2	Homo sapiens	32-48
8908158-5	1996	Staurosporine and calphostin C, protein kinase C (PKC) inhibitors, blocked the increased in sphingosine kinase activity, suggesting a PKC-dependent regulation.	calphostin C	18-30	proline rich transmembrane protein 2	Homo sapiens	50-53
8908158-5	1996	Staurosporine and calphostin C, protein kinase C (PKC) inhibitors, blocked the increased in sphingosine kinase activity, suggesting a PKC-dependent regulation.	calphostin C	18-30	proline rich transmembrane protein 2	Homo sapiens	134-137
8871536-4	1996	Furthermore, this MMP-2 activity could be inhibited by the treatment of tumor cells with calphostin C, a specific inhibitor of PKC.	calphostin C	89-101	matrix metallopeptidase 2	Homo sapiens	18-23
8871536-5	1996	Glioma cell lines treated with calphostin C demonstrated a dose-dependent decrease (IC50 = 30 nM) in tumor invasiveness with a concomitant reduction in the activity of the MMP-2.	calphostin C	31-43	matrix metallopeptidase 2	Homo sapiens	172-177
8943704-8	1996	Activation of the protein kinase C pathway in these cells with the phorbol ester PMA significantly increased the release of soluble p55 (P < or = 0.001); whereas, pharmacological inhibition of protein kinase C with calphostin-C significantly decreased the shedding of p55 (P < or = 0.001).	calphostin C	218-230	TNF receptor superfamily member 1A	Homo sapiens	132-135
8753766-6	1996	H-7 (50 microM) and Calphostin C (10(-6) M) alone lowered basal ANP and BNP levels.	calphostin C	20-32	natriuretic peptide B	Rattus norvegicus	72-75
8760293-6	1996	Calphostin C, an inhibitor of protein kinase C blocks the effect of (R)PAF on p125FAK phosphorylation suggesting that protein kinase C activation is up-stream the activation of this tyrosine kinase.	calphostin C	0-12	PCNA clamp associated factor	Homo sapiens	71-74
8760293-6	1996	Calphostin C, an inhibitor of protein kinase C blocks the effect of (R)PAF on p125FAK phosphorylation suggesting that protein kinase C activation is up-stream the activation of this tyrosine kinase.	calphostin C	0-12	protein tyrosine kinase 2	Homo sapiens	78-85
9812733-2	1996	METHODS: The effects of phorbol 12-myristate 13-acetate (PMA, a PKC activator) and Calphostin C (a selective PKC inhibitor) were observed on the sustained contraction of rat aorta induced by K+ 136 mmol.L-1.	calphostin C	83-95	protein kinase C, gamma	Rattus norvegicus	109-112
8616873-7	1996	Calphostin C, a PKC inhibitor, blocked the stimulation of adhesion by A23187, exogenous AA, and TPA to both collagen IV and vitronectin.	calphostin C	0-12	vitronectin	Homo sapiens	124-135
8660356-4	1996	Activating effects of ACTH which activates cyclic AMP formation on the StAR protein and cortisol production were inhibited by pretreatment with calphostin C which is a protein kinase C inhibitor, suggesting that ACTH enhances expression of the StAR protein possibly via both of two signal transduction systems such as cyclic AMP- and protein kinase C-dependent processes.	calphostin C	144-156	steroidogenic acute regulatory protein	Bos taurus	71-75
8660356-4	1996	Activating effects of ACTH which activates cyclic AMP formation on the StAR protein and cortisol production were inhibited by pretreatment with calphostin C which is a protein kinase C inhibitor, suggesting that ACTH enhances expression of the StAR protein possibly via both of two signal transduction systems such as cyclic AMP- and protein kinase C-dependent processes.	calphostin C	144-156	steroidogenic acute regulatory protein	Bos taurus	244-248
8664272-6	1996	Treatment with calphostin C, a PKC inhibitor which decreases Pgp phosphorylation, increased progesterone efflux, modulated Pgp antagonism by steroids, and inhibited photoaffinity labeling of Pgp by progesterone.	calphostin C	15-27	ATP binding cassette subfamily B member 1	Homo sapiens	61-64
8664272-6	1996	Treatment with calphostin C, a PKC inhibitor which decreases Pgp phosphorylation, increased progesterone efflux, modulated Pgp antagonism by steroids, and inhibited photoaffinity labeling of Pgp by progesterone.	calphostin C	15-27	ATP binding cassette subfamily B member 1	Homo sapiens	123-126
8664272-6	1996	Treatment with calphostin C, a PKC inhibitor which decreases Pgp phosphorylation, increased progesterone efflux, modulated Pgp antagonism by steroids, and inhibited photoaffinity labeling of Pgp by progesterone.	calphostin C	15-27	ATP binding cassette subfamily B member 1	Homo sapiens	123-126
8621772-3	1996	Urea inducibility of Egr-1 expression was protein kinase C (PKC)-dependent because staurosporine and calphostin C abrogated the urea effect, and down-regulation of PHC through chronic TPa treatment inhibited both urea-inducible Egr-1 protein expression and gene transcription.	calphostin C	101-113	early growth response 1	Mus musculus	21-26
8625914-6	1996	The protein kinase C inhibitors chelerythrine (3 microns), calphostin C (100 nM), and staurosporine (10 nM) also blocked fibroblast growth factor but not angiotensin II induction of IGF-I receptor mRNA.	calphostin C	59-71	insulin-like growth factor 1 receptor	Rattus norvegicus	182-196
8613911-2	1996	We show that the protein kinase C (PKC) antagonists (1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride) and calphostin C reduce spontaneous resting tone in LES muscle strips, whereas the calmodulin antagonist N-(6-aminohexyl-5-chloro-1-naphthalenesulfonamide hydrochloride) has no effect, which suggests that LES tone is maintained by a PKC-mediated mechanism.	calphostin C	121-133	proline rich transmembrane protein 2	Homo sapiens	350-353
8642682-2	1996	Treatment of cells with calphostin C, a protein kinase C (PKC) inhibitor, blocked induction of NF-kappa B DNA binding activity in human T-cell lymphotropic virus type 1-transformed C81 cells and Tax1-stimulated murine pre-B cells, suggesting that PKC was an important intermediate in the NF-kappa B induction pathway.	calphostin C	24-36	nuclear factor kappa B subunit 1	Homo sapiens	95-105
8642682-2	1996	Treatment of cells with calphostin C, a protein kinase C (PKC) inhibitor, blocked induction of NF-kappa B DNA binding activity in human T-cell lymphotropic virus type 1-transformed C81 cells and Tax1-stimulated murine pre-B cells, suggesting that PKC was an important intermediate in the NF-kappa B induction pathway.	calphostin C	24-36	contactin 2	Homo sapiens	195-199
8642682-2	1996	Treatment of cells with calphostin C, a protein kinase C (PKC) inhibitor, blocked induction of NF-kappa B DNA binding activity in human T-cell lymphotropic virus type 1-transformed C81 cells and Tax1-stimulated murine pre-B cells, suggesting that PKC was an important intermediate in the NF-kappa B induction pathway.	calphostin C	24-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	288-298
8638724-5	1996	This conclusion is supported by the observation that the GRP-induced secretion is inhibited by calphostin C, an inhibitor of protein kinase C, but not by H-89, an inhibitor of cAMP-dependent protein kinase.	calphostin C	95-107	gastrin releasing peptide	Rattus norvegicus	57-60
9238710-3	1996	When spermatozoa were preincubated with PKA, PKC and PTK inhibitor (KT5720, calphostin C and genistein) for 15 min prior to addition of PAF, there was a significantly reduced acrosome reaction induced by PAF, but complete inhibition was not observed.	calphostin C	76-88	protein tyrosine kinase 2 beta	Homo sapiens	53-56
8780012-4	1996	Moreover, pretreatment of PC12 cells with the protein kinase inhibitor staurosporine or with calphostin C, a specific inhibitor of PKC, also blocks the increase of AA release induced by NGF.	calphostin C	93-105	protein kinase C, alpha	Rattus norvegicus	131-134
8599832-4	1996	PKC inhibitors H7, calphostin C, chelerythrine, and bisindolylmaleimide completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibodies.	calphostin C	19-31	interleukin 16	Homo sapiens	89-94
8845176-4	1996	Interleukin (IL)-1beta also induced concentration-dependent sTNF-RI shedding from NCI-H292 cells, which could be inhibited by the PKC inhibitor calphostin C.	calphostin C	144-156	interleukin 1 beta	Homo sapiens	0-22
8595959-9	1996	ICAM-1 induction by TNF treatment was inhibited by calphostin C pretreatment and not by H8 pretreatment.	calphostin C	51-63	intercellular adhesion molecule 1	Homo sapiens	0-6
8595959-9	1996	ICAM-1 induction by TNF treatment was inhibited by calphostin C pretreatment and not by H8 pretreatment.	calphostin C	51-63	tumor necrosis factor	Homo sapiens	20-23
9238710-3	1996	When spermatozoa were preincubated with PKA, PKC and PTK inhibitor (KT5720, calphostin C and genistein) for 15 min prior to addition of PAF, there was a significantly reduced acrosome reaction induced by PAF, but complete inhibition was not observed.	calphostin C	76-88	PCNA clamp associated factor	Homo sapiens	136-139
9238710-3	1996	When spermatozoa were preincubated with PKA, PKC and PTK inhibitor (KT5720, calphostin C and genistein) for 15 min prior to addition of PAF, there was a significantly reduced acrosome reaction induced by PAF, but complete inhibition was not observed.	calphostin C	76-88	PCNA clamp associated factor	Homo sapiens	204-207
8852950-10	1996	Moreover, IL-1 beta-induced PGHS-2 mRNA expression and formation of TRAP-positive MNC were inhibited by calphostin C, a selective inhibitor of protein kinase C (PKC).	calphostin C	104-116	interleukin 1 beta	Mus musculus	10-19
8852950-10	1996	Moreover, IL-1 beta-induced PGHS-2 mRNA expression and formation of TRAP-positive MNC were inhibited by calphostin C, a selective inhibitor of protein kinase C (PKC).	calphostin C	104-116	prostaglandin-endoperoxide synthase 2	Mus musculus	28-34
8599832-4	1996	PKC inhibitors H7, calphostin C, chelerythrine, and bisindolylmaleimide completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibodies.	calphostin C	19-31	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	172-177
8599832-4	1996	PKC inhibitors H7, calphostin C, chelerythrine, and bisindolylmaleimide completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibodies.	calphostin C	19-31	CD4 molecule	Homo sapiens	187-190
8611631-6	1996	Treatment with TNF-alpha for 4-24 h increased the cPLA2 protein and mRNA levels which were blocked by the broad inhibitor of protein kinases staurosporine, the protein kinase C (PKC) inhibitor calphostin C, and to a lesser extent the calcium/calmodulin-dependent protein kinase inhibitor W-7.	calphostin C	193-205	tumor necrosis factor	Homo sapiens	15-24
8611631-6	1996	Treatment with TNF-alpha for 4-24 h increased the cPLA2 protein and mRNA levels which were blocked by the broad inhibitor of protein kinases staurosporine, the protein kinase C (PKC) inhibitor calphostin C, and to a lesser extent the calcium/calmodulin-dependent protein kinase inhibitor W-7.	calphostin C	193-205	phospholipase A2 group IVA	Homo sapiens	50-55
8611633-7	1996	The stimulatory effect of CGP 41251 on gelatinase B production in RAW 264.7 was: (a) inhibited by calphostin C (as is the LPS-induced response), indicating a PKC-dependence; (b) inhibited by dexamethasone (as opposed to the LPS-induced response); and (c) enhanced by addition of trans-retinoic acid (RA).	calphostin C	98-110	matrix metallopeptidase 9	Mus musculus	39-51
8825421-0	1996	Calphostin C induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in a pathway independent of tumor promoter phorbol ester-mediated down-regulation of protein kinase C. The signal transduction mechanism of protein kinase FA/GSK-3 alpha by tyrosine phosphorylation in A431 cells was investigated using calphostin C as an inhibitor for protein kinase C (PKC).	calphostin C	329-341	glycogen synthase kinase 3 alpha	Homo sapiens	82-93
8739558-13	1996	However, inhibition of PKC activation by CPC does not affect the melanocyte morphology, and CPC reduces melanocyte adhesion to uncoated or type IV collagen coated plastic cell culture dishes.	calphostin C	41-44	proline rich transmembrane protein 2	Homo sapiens	23-26
9244191-6	1996	HB-EGF in Mahlavu cells appears to be regulated by a protein kinase C (PKC) pathway, since PKC inhibitors, H7, staurosporin, and calphostin C, abrogated the induction of HB-EGF mRNA by TPA.	calphostin C	129-141	heparin binding EGF like growth factor	Homo sapiens	0-6
9244191-6	1996	HB-EGF in Mahlavu cells appears to be regulated by a protein kinase C (PKC) pathway, since PKC inhibitors, H7, staurosporin, and calphostin C, abrogated the induction of HB-EGF mRNA by TPA.	calphostin C	129-141	heparin binding EGF like growth factor	Homo sapiens	170-176
8825421-5	1996	Since kinase FA/GSK-3 alpha is a possible carcinoma dedifferentiation/progression-promoting factor, the results further suggest calphostin C as a potential anticancer drug involved in blocking carcinoma dedifferentiation/progression, possibly via inactivation of protein kinase FA/GSK-3 alpha in tumor cells.	calphostin C	128-140	glycogen synthase kinase 3 alpha	Homo sapiens	16-27
8592100-5	1996	Northern blot analysis showed that cytokine-induced tissue factor mRNA was significantly reduced in human umbilical vein endothelial cells treated with calphostin C, a specific protein kinase C inhibitor.	calphostin C	152-164	coagulation factor III, tissue factor	Homo sapiens	52-65
8825421-5	1996	Since kinase FA/GSK-3 alpha is a possible carcinoma dedifferentiation/progression-promoting factor, the results further suggest calphostin C as a potential anticancer drug involved in blocking carcinoma dedifferentiation/progression, possibly via inactivation of protein kinase FA/GSK-3 alpha in tumor cells.	calphostin C	128-140	glycogen synthase kinase 3 alpha	Homo sapiens	281-292
8592100-7	1996	Calphostin C also inhibited phorbol myristate acetate-induced tissue factor expression.	calphostin C	0-12	coagulation factor III, tissue factor	Homo sapiens	62-75
8961380-5	1996	In contrast to the effects of BAPTA-AM and heparin, protein kinase C (PKC) inhibitors, H-7 and calphostin C, completely inhibited substance P induced oxyradical production without any significant effects on [Ca2+]i increase.	calphostin C	95-107	tachykinin precursor 1	Homo sapiens	130-141
8572244-4	1995	Electrophoretic mobility shift assays demonstrated that protein binding to NF-kappa B and AP-1 sequences increases over 1-2 h after stress relative to time-matched controls and resolves by 24 h. The selective protein kinase C inhibitor, calphostin C, prevents approximately 30% of this increase.	calphostin C	237-249	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
8606529-10	1995	In the ET-1- and TPA-pretreated dog mesenteric veins, 10(-6)M calphostin C decreased maximal tensions of enhanced UK-14304-induced contractions to the same level as the UK-14304-induced maximal tension inhibited by 10(-6)M calphostin C in untreated dog mesenteric vein.	calphostin C	62-74	endothelin 1	Canis lupus familiaris	7-11
7579389-6	1995	Moreover, pretreatment of cells with the PKC inhibitor, calphostin C (1 mumol/L), caused a marked decrease of c-jun expression induced by TPA, but had no influence on c-jun expression induced by arachidonate.	calphostin C	56-68	jun proto-oncogene	Mus musculus	110-115
7595543-5	1995	Calphostin C, an inhibitor of protein kinase C, also completely inhibited interleukin-6 production.	calphostin C	0-12	interleukin 6	Homo sapiens	74-87
7593207-3	1995	12(S)-HETE treatment resulted in a time-dependent increase in B16a cell spreading on fibronectin, which was blocked by either calphostin C or by genistein but not by H8.	calphostin C	126-138	fibronectin 1	Mus musculus	85-96
8847268-4	1995	Pretreatment with the ETA receptor antagonist BQ-610 (10(-7) M) or the protein kinase C inhibitors staurosporine (10(-6) M) and calphostin C (10(-6) M) completely blocked the pressor effect of ET-1.	calphostin C	128-140	endothelin 1	Canis lupus familiaris	193-197
7586373-11	1995	The protein kinase C inhibitor calphostin C dose-dependently blocked the effect of Ang II.	calphostin C	31-43	angiotensinogen	Rattus norvegicus	83-89
7595513-7	1995	To investigate the involvement of protein kinase C (PKC) in the survival of granular neurons, we show here activation of PKC after BDNF or TPA treatment and blocking of the observed survival-promoting effects of BDNF and TPA with calphostin C, a specific PKC inhibitor.	calphostin C	230-242	brain-derived neurotrophic factor	Rattus norvegicus	212-216
7589452-5	1995	When calphostin C (20 microM) was added to sub-confluent monolayer cultures, serine-phosphorylation of FAK was inhibited by 67% within 2 h, and decrease in the amount of FAK and rounding up of the cells began after 4 h. Label-chase experiments indicated that about 60% of 35S-labeled FAK degraded within 1-2 h after addition of calphostin C to monolayer cultures.	calphostin C	5-17	PTK2 protein tyrosine kinase 2	Mus musculus	103-106
7589452-5	1995	When calphostin C (20 microM) was added to sub-confluent monolayer cultures, serine-phosphorylation of FAK was inhibited by 67% within 2 h, and decrease in the amount of FAK and rounding up of the cells began after 4 h. Label-chase experiments indicated that about 60% of 35S-labeled FAK degraded within 1-2 h after addition of calphostin C to monolayer cultures.	calphostin C	5-17	PTK2 protein tyrosine kinase 2	Mus musculus	170-173
7589452-5	1995	When calphostin C (20 microM) was added to sub-confluent monolayer cultures, serine-phosphorylation of FAK was inhibited by 67% within 2 h, and decrease in the amount of FAK and rounding up of the cells began after 4 h. Label-chase experiments indicated that about 60% of 35S-labeled FAK degraded within 1-2 h after addition of calphostin C to monolayer cultures.	calphostin C	5-17	PTK2 protein tyrosine kinase 2	Mus musculus	170-173
7589452-5	1995	When calphostin C (20 microM) was added to sub-confluent monolayer cultures, serine-phosphorylation of FAK was inhibited by 67% within 2 h, and decrease in the amount of FAK and rounding up of the cells began after 4 h. Label-chase experiments indicated that about 60% of 35S-labeled FAK degraded within 1-2 h after addition of calphostin C to monolayer cultures.	calphostin C	328-340	PTK2 protein tyrosine kinase 2	Mus musculus	103-106
7573430-5	1995	Calphostin C, a potent and specific inhibitor of protein kinase C, also suppressed the formation of choline induced by STA2.	calphostin C	0-12	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Mus musculus	119-123
7485529-7	1995	TNF- and PMA-induced effects were prevented with the specific PKC inhibitor calphostin C (1 microM).	calphostin C	76-88	tumor necrosis factor	Homo sapiens	0-3
7559811-14	1995	In addition, calphostin C (a specific inhibitor of protein kinase C), but not H89 (a specific inhibitor of protein kinase A), inhibited the IGF-1 action.	calphostin C	13-25	insulin like growth factor 1	Homo sapiens	140-145
8573741-6	1995	Increasing PKC activity by treatment with a DAG analogue or active phorbol ester stimulated luciferase activity preferentially in G100; addition of the PKC inhibitors staurosporine or calphostin C markedly inhibited luciferase activity preferentially in G450.	calphostin C	184-196	protein kinase C, gamma	Rattus norvegicus	11-14
8573741-6	1995	Increasing PKC activity by treatment with a DAG analogue or active phorbol ester stimulated luciferase activity preferentially in G100; addition of the PKC inhibitors staurosporine or calphostin C markedly inhibited luciferase activity preferentially in G450.	calphostin C	184-196	protein kinase C, gamma	Rattus norvegicus	152-155
7653654-4	1995	Renal pelvic perfusion with the PKC inhibitors calphostin C (1 microM), staurosporine (20 nM), and H-7 (40 microM) reduced the ARNA responses to bradykinin (20 microM) by 69 +/- 10, 76 +/- 10, and 77 +/- 10%, respectively (all P < 0.01).	calphostin C	47-59	protein kinase C, gamma	Rattus norvegicus	32-35
7543105-11	1995	Staurosporine and calphostin C, inhibitors of protein kinase C, blocked internalization and subsequent degradation of vitronectin, while KT5720, an inhibitor of protein kinase A, had no effect on the degradation of vitronectin.	calphostin C	18-30	vitronectin	Homo sapiens	118-129
7573482-3	1995	Both staurosporine (5 x 10(-8) M) and calphostin C (10(-8) M), inhibitors of protein kinase C, blocked the EGF stimulation of JPhos, indicating that protein kinase C is involved in EGF signaling.	calphostin C	38-50	pro-epidermal growth factor	Oryctolagus cuniculus	107-110
7573482-3	1995	Both staurosporine (5 x 10(-8) M) and calphostin C (10(-8) M), inhibitors of protein kinase C, blocked the EGF stimulation of JPhos, indicating that protein kinase C is involved in EGF signaling.	calphostin C	38-50	pro-epidermal growth factor	Oryctolagus cuniculus	181-184
7635530-8	1995	The thrombin effect was inhibited by calphostin C (1 mumol/L), an inhibitor of protein kinase C. Endothelial neutral endopeptidase is constitutively expressed in endothelial cells from different origins and is inducible by thrombin via activation of the protein kinase C pathway.	calphostin C	37-49	coagulation factor II, thrombin	Homo sapiens	4-12
7635530-8	1995	The thrombin effect was inhibited by calphostin C (1 mumol/L), an inhibitor of protein kinase C. Endothelial neutral endopeptidase is constitutively expressed in endothelial cells from different origins and is inducible by thrombin via activation of the protein kinase C pathway.	calphostin C	37-49	coagulation factor II, thrombin	Homo sapiens	223-231
7608562-8	1995	IL-4, like macrophage CSF, translocates PKC-alpha to the nucleus in GM-CFC, this redistribution of protein kinase C alpha (PKC-alpha) being inhibited by calphostin C (a PKC inhibitor).	calphostin C	153-165	interleukin 4	Homo sapiens	0-4
7628389-11	1995	Calphostin C (1 microM) completely reversed the inhibitory effect of TNF alpha or PMA.	calphostin C	0-12	tumor necrosis factor	Mus musculus	69-78
7651367-7	1995	Drug sensitivity was restored in cells with active v-Abl PTK by simultaneous addition of calphostin C, an inhibitor of protein kinase C, suggesting a role for protein kinase C in the suppression of drug-induced apoptosis by v-Abl PTK.	calphostin C	89-101	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	53-56
7651367-7	1995	Drug sensitivity was restored in cells with active v-Abl PTK by simultaneous addition of calphostin C, an inhibitor of protein kinase C, suggesting a role for protein kinase C in the suppression of drug-induced apoptosis by v-Abl PTK.	calphostin C	89-101	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	226-229
7608562-8	1995	IL-4, like macrophage CSF, translocates PKC-alpha to the nucleus in GM-CFC, this redistribution of protein kinase C alpha (PKC-alpha) being inhibited by calphostin C (a PKC inhibitor).	calphostin C	153-165	colony stimulating factor 2	Homo sapiens	22-25
7608562-8	1995	IL-4, like macrophage CSF, translocates PKC-alpha to the nucleus in GM-CFC, this redistribution of protein kinase C alpha (PKC-alpha) being inhibited by calphostin C (a PKC inhibitor).	calphostin C	153-165	protein kinase C alpha	Homo sapiens	40-49
7632168-0	1995	Inhibition of diacylglycerol kinase by the antitumor agent calphostin C.	calphostin C	59-71	diacylglycerol kinase beta	Homo sapiens	14-35
7632168-1	1995	Evidence for similarity between the active site of diacylglycerol kinase and the regulatory site of protein kinase C. Calphostin C is an anti-tumor agent that binds to the regulatory domain of protein kinase C and inhibits the binding of phorbol dibutyrate.	calphostin C	118-130	diacylglycerol kinase beta	Homo sapiens	51-72
7608562-8	1995	IL-4, like macrophage CSF, translocates PKC-alpha to the nucleus in GM-CFC, this redistribution of protein kinase C alpha (PKC-alpha) being inhibited by calphostin C (a PKC inhibitor).	calphostin C	153-165	protein kinase C alpha	Homo sapiens	99-121
7632168-7	1995	The inhibition of DGK by calphostin C was competitive with respect to diacylglycerol and was not affected by the presence or absence of phosphatidylserine.	calphostin C	25-37	diacylglycerol kinase beta	Homo sapiens	18-21
7608562-8	1995	IL-4, like macrophage CSF, translocates PKC-alpha to the nucleus in GM-CFC, this redistribution of protein kinase C alpha (PKC-alpha) being inhibited by calphostin C (a PKC inhibitor).	calphostin C	153-165	protein kinase C alpha	Homo sapiens	123-132
7608562-8	1995	IL-4, like macrophage CSF, translocates PKC-alpha to the nucleus in GM-CFC, this redistribution of protein kinase C alpha (PKC-alpha) being inhibited by calphostin C (a PKC inhibitor).	calphostin C	153-165	protein kinase C alpha	Homo sapiens	40-43
7593300-2	1995	Cellular signalling events associated with the activation of v-ABL included increased levels of sn-1,2-diacylglycerol, an activator of protein kinase C. Calphostin C, a PKC inhibitor, restored apoptosis to interleukin-3-deprived IC.DP cells expressing active v-ABL.	calphostin C	153-165	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	61-66
7631804-4	1995	The initial increase in AA release coincided with the initial Ca2+ transient and muscle contraction: all three events were abolished by guanosine 5"-O-(2-thiodiphosphate), pertussis toxin (PTX), and the phospholipase A2 (PLA2) inhibitor, dimethyleicosadienoic acid, but were not affected by calphostin C or neomycin.	calphostin C	291-303	phospholipase A2 group IB	Homo sapiens	203-219
7547506-4	1995	Furthermore, PKC inhibitors, such as staurosporine or calphostin C, prevent TPA-induced differentiation but not cell growth arrest.	calphostin C	54-66	protein kinase C alpha	Homo sapiens	13-16
7593300-2	1995	Cellular signalling events associated with the activation of v-ABL included increased levels of sn-1,2-diacylglycerol, an activator of protein kinase C. Calphostin C, a PKC inhibitor, restored apoptosis to interleukin-3-deprived IC.DP cells expressing active v-ABL.	calphostin C	153-165	interleukin 3	Homo sapiens	206-219
7593300-2	1995	Cellular signalling events associated with the activation of v-ABL included increased levels of sn-1,2-diacylglycerol, an activator of protein kinase C. Calphostin C, a PKC inhibitor, restored apoptosis to interleukin-3-deprived IC.DP cells expressing active v-ABL.	calphostin C	153-165	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	259-264
7775410-5	1995	Staurosporin and Calphostin C, inhibitors of PKC, block the ability of TGF-beta 1 to initiate transcription of the luciferase gene.	calphostin C	17-29	proline rich transmembrane protein 2	Homo sapiens	45-48
7597083-6	1995	In addition, ZO-1 was phosphorylated subsequent to the initiation of cell-cell contact, and treatment with calphostin C prevented approximately 85% of the phosphorylation increase.	calphostin C	107-119	tight junction protein 1	Homo sapiens	13-17
7775410-5	1995	Staurosporin and Calphostin C, inhibitors of PKC, block the ability of TGF-beta 1 to initiate transcription of the luciferase gene.	calphostin C	17-29	transforming growth factor beta 1	Homo sapiens	71-81
7544689-8	1995	Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes.	calphostin C	79-91	interleukin 1 beta	Rattus norvegicus	27-36
7544689-8	1995	Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes.	calphostin C	79-91	interleukin 1 beta	Rattus norvegicus	150-159
7537738-9	1995	Calphostin C, a compound described as a selective inhibitor of PKC, was also able to inhibit [3H]PDBu binding to Unc-13, suggesting that this inhibitor is not able to distinguish between different classes of phorbol ester receptors.	calphostin C	0-12	Phorbol ester/diacylglycerol-binding protein unc-13	Caenorhabditis elegans	113-119
7741713-1	1995	The stimulatory effects of both PDGF-BB and TGF-beta 1 were dependent on protein kinase C (PKC), since the PKC inhibitor calphostin C inhibited the stimulation by the growth factors.	calphostin C	121-133	transforming growth factor beta 1	Homo sapiens	44-54
7539147-7	1995	The enhanced vasoconstriction to angiotensin II, serotonin, KCl, and phenylephrine could be mimicked in normal vessels by addition of subthreshold concentrations of endothelin 1, and this effect was prevented by calphostin C.	calphostin C	212-224	endothelin-1	Oryctolagus cuniculus	165-177
7538184-10	1995	In contrast, daily co-administration of a potent and selective protein kinase C inhibitor, calphostin C (4 micrograms), inhibited the neovascular response elicited by 3 pmol of IL-1 alpha.	calphostin C	91-103	interleukin 1 alpha	Rattus norvegicus	177-187
7536413-3	1995	The protein kinase C-selective inhibitors chelerythrine, staurosporine and calphostin C acted as potent inhibitors of the desensitization process but with various degrees of selectivity regarding their ability to inhibit the desensitizing actions of glucagon and vasopressin.	calphostin C	75-87	arginine vasopressin	Rattus norvegicus	263-274
7722482-4	1995	This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner.	calphostin C	106-118	interleukin 1 beta	Rattus norvegicus	167-185
7722482-4	1995	This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner.	calphostin C	106-118	interleukin 6	Rattus norvegicus	196-209
7722482-6	1995	The treatment of cortical astrocytes with both interleukin 1 beta (3 ng/ml) and phorbol 12-myristate 13-acetate (10 nM) caused a synergistic stimulation of interleukin 6 release and its gene expression, an effect that was not relieved by either 20 nM staurospine or by calphostin C but was slightly affected by protein kinase C desensitization.	calphostin C	269-281	interleukin 1 beta	Rattus norvegicus	47-65
7722482-6	1995	The treatment of cortical astrocytes with both interleukin 1 beta (3 ng/ml) and phorbol 12-myristate 13-acetate (10 nM) caused a synergistic stimulation of interleukin 6 release and its gene expression, an effect that was not relieved by either 20 nM staurospine or by calphostin C but was slightly affected by protein kinase C desensitization.	calphostin C	269-281	interleukin 6	Rattus norvegicus	156-169
7722482-7	1995	In conclusion, our data show that in rat cortical astrocytes the basal release of interleukin 6 is under a tonic inhibition exerted by a protein kinase C isoform or isoforms sensitive to blockade by staurosporine and desensitization but insensitive to calphostin C.	calphostin C	252-264	interleukin 6	Rattus norvegicus	82-95
7961634-8	1994	In contrast, inhibition of protein kinase C by calphostin C and chelerythrine or down-regulation with phorbol 12-myristate 13-acetate drastically reduces PGE2 and arachidonic acid-induced c-fos and Egr-1 mRNA levels.	calphostin C	47-59	FBJ osteosarcoma oncogene	Mus musculus	188-193
7996052-5	1994	IL-8 and fMLP induced an increase in cellular cyclic AMP and the response to optimal concentrations of chemoattractants was inhibited by Calphostin C and Ro 31-8220, inhibitors of protein kinase C (PKC).	calphostin C	137-149	interleukin-8	Cavia porcellus	0-4
7961846-5	1994	Staurosporin and calphostin C, two inhibitors of protein kinase C, but not of H8, a protein kinase A inhibitor, were able to block Trx-dependent proliferation.	calphostin C	17-29	thioredoxin	Homo sapiens	131-134
7655425-6	1995	The finding was reconfirmed by the result that fluoride-stimulated glucose-6-phosphatase activity was further enhanced by treatment with calphostin C (200 nmol/kg, i.p.	calphostin C	137-149	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	67-88
7615646-4	1995	The protein kinase C (PKC) inhibitors, H-7, staurosporine, and calphostin C, reversed the rhIL-1 beta induction of TIMP-1 mRNA.	calphostin C	63-75	TIMP metallopeptidase inhibitor 1	Homo sapiens	115-121
7778066-6	1995	The pHi-stimulating effect of endothelin-1 was inhibited by 10(-7) M staurosporine, calphostin C and 5-(N,N-hexamethylene) amiloride.	calphostin C	84-96	glucose-6-phosphate isomerase	Homo sapiens	4-7
7778066-6	1995	The pHi-stimulating effect of endothelin-1 was inhibited by 10(-7) M staurosporine, calphostin C and 5-(N,N-hexamethylene) amiloride.	calphostin C	84-96	endothelin 1	Homo sapiens	30-42
7535750-4	1995	Daily doses of recombinant human basic fibroblast growth factor (bFGF, 100 ng), tumor necrosis factor-alpha (TNF-alpha, 50 ng), or interleukin-1-alpha (IL-1 alpha, 50 ng) caused neovascular responses that were blocked by daily coadministration of the selective PKC inhibitor, calphostin C (4 micrograms).	calphostin C	276-288	fibroblast growth factor 2	Homo sapiens	33-63
7535750-4	1995	Daily doses of recombinant human basic fibroblast growth factor (bFGF, 100 ng), tumor necrosis factor-alpha (TNF-alpha, 50 ng), or interleukin-1-alpha (IL-1 alpha, 50 ng) caused neovascular responses that were blocked by daily coadministration of the selective PKC inhibitor, calphostin C (4 micrograms).	calphostin C	276-288	interleukin 1 alpha	Homo sapiens	131-150
7529505-1	1995	Both PKC-alpha (a Ca(2+)-dependent conventional isoform) and PKC-epsilon (a Ca(2+)-independent novel isoform) are similarly inactivated by calphostin C (75-100 nM produced 50% inhibition), suggesting that inactivation requires a site common to both classes of PKC.	calphostin C	139-151	protein kinase C alpha	Bos taurus	5-14
7529505-1	1995	Both PKC-alpha (a Ca(2+)-dependent conventional isoform) and PKC-epsilon (a Ca(2+)-independent novel isoform) are similarly inactivated by calphostin C (75-100 nM produced 50% inhibition), suggesting that inactivation requires a site common to both classes of PKC.	calphostin C	139-151	protein kinase C epsilon	Bos taurus	61-72
7529505-1	1995	Both PKC-alpha (a Ca(2+)-dependent conventional isoform) and PKC-epsilon (a Ca(2+)-independent novel isoform) are similarly inactivated by calphostin C (75-100 nM produced 50% inhibition), suggesting that inactivation requires a site common to both classes of PKC.	calphostin C	139-151	protein kinase C alpha	Bos taurus	5-8
7529505-5	1995	In addition to aa 92-140, PKC-stimulating cofactors (phosphatidylserine, phorbol ester, and Ca2+) are required for inactivation by calphostin C even in the case of PKC mutants that do not require these cofactors for enzymatic activity.	calphostin C	131-143	protein kinase C alpha	Bos taurus	26-29
8835291-2	1995	Exposure of chloroma cells to calphostin C (a specific PKC inhibitor) led to inhibition of cell proliferation, caused by (i) partial and transient arrest of cells in the G1 phase of the cell cycle and (ii) induction of apoptosis in part of the cell population.	calphostin C	30-42	protein kinase C, gamma	Rattus norvegicus	55-58
7527042-6	1994	The activation of Raf-1 kinase and MAP kinase is inhibited by phorbol 12-myristate 13-acetate pretreatment in the presence of calphostin C or H-7.	calphostin C	126-138	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	18-23
8002245-12	1994	The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway.	calphostin C	58-70	interferon gamma	Homo sapiens	24-33
8002245-12	1994	The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway.	calphostin C	58-70	transforming growth factor beta 1	Homo sapiens	38-46
7525254-8	1994	Similary, staurosporine, calphostin C, guanosine 5"-O-1(2-thiodiphosphate), and pertussis toxin inhibited the effect of PTH on [Ca2+]i of adipocytes.	calphostin C	25-37	parathyroid hormone	Rattus norvegicus	120-123
7531168-7	1994	In contrast, PKC inhibition by staurosporine and calphostin C resulted in increased phagocytosis.	calphostin C	49-61	proline rich transmembrane protein 2	Homo sapiens	13-16
7977736-7	1994	Staurosporine abolished the effect of TPA, and both staurosporine and calphostin C partially inhibited the effect of PTH.	calphostin C	70-82	parathyroid hormone	Rattus norvegicus	117-120
7923629-8	1994	To clarify the role of PKC in vasoconstrictor-stimulated VSMC production of bFGF and hypertrophy, PKC was down-regulated by prolonged exposure to PMA or was inhibited with calphostin C or staurosporine before the addition of TXA2 or Ang II.	calphostin C	172-184	protein kinase C alpha	Homo sapiens	98-101
7525931-5	1994	Staurosporine and calphostin C, which are two PKC inhibitors, inhibited EGF-induced enzyme activity and mRNA expression of 12-lipoxygenase.	calphostin C	18-30	protein kinase C alpha	Homo sapiens	46-49
8790599-5	1994	Calphostin C, a specific inhibitor of PKC, inhibited NF-kappa B activation and HIV-1 LTR-driven reporter gene expression in both PMA- and TNF-alpha-treated cells.	calphostin C	0-12	nuclear factor kappa B subunit 1	Homo sapiens	53-63
8790599-5	1994	Calphostin C, a specific inhibitor of PKC, inhibited NF-kappa B activation and HIV-1 LTR-driven reporter gene expression in both PMA- and TNF-alpha-treated cells.	calphostin C	0-12	tumor necrosis factor	Homo sapiens	138-147
7524364-6	1994	The enhanced beta-responsiveness produced by IL-1 was eliminated by adding amiloride to block Na+/H+ exchange or protein kinase C inhibitors staurosporine (10 nM) and calphostin C (50 nM).	calphostin C	167-179	interleukin 1 beta	Homo sapiens	45-49
7525931-5	1994	Staurosporine and calphostin C, which are two PKC inhibitors, inhibited EGF-induced enzyme activity and mRNA expression of 12-lipoxygenase.	calphostin C	18-30	epidermal growth factor	Homo sapiens	72-75
7868057-10	1994	Addition of calphostin C, a specific protein kinase C (PKC) inhibitor or genistein and herbimycin A, specific tyrosine kinase (TK) inhibitors to the culture also decreased colony numbers formed with IL-6 and TPA.	calphostin C	12-24	interleukin 6	Mus musculus	199-203
7943255-7	1994	Intraperitoneal treatment with calphostin C (3 microM, 15 min prior to treatment with TNF) prevented the effects of TNF on 1) PKC activation, 2) the hemodynamic responses to U-46619, and 3) the levels of NO2- and O2(.).	calphostin C	31-43	tumor necrosis factor	Cavia porcellus	86-89
7943255-7	1994	Intraperitoneal treatment with calphostin C (3 microM, 15 min prior to treatment with TNF) prevented the effects of TNF on 1) PKC activation, 2) the hemodynamic responses to U-46619, and 3) the levels of NO2- and O2(.).	calphostin C	31-43	tumor necrosis factor	Cavia porcellus	116-119
7943258-5	1994	The decrease in NO2- and the increase in lipid peroxides in response to TNF were prevented by pretreatment (15 min prior to and throughout the incubation) with either calphostin C (1 microM; a specific PKC inhibitor) or the antioxidants N-acetylcysteine (1 mM), 4,5-dihydroxy-1,3-benzene disulfonic acid (Tiron) (10 mM), and superoxide dismutase (10 U/ml).	calphostin C	167-179	tumor necrosis factor	Bos taurus	72-75
7943258-7	1994	Pretreatment with calphostin C or N-acetylcysteine prior to TNF (10 U/ml) revealed an increase in NO2- levels above control treatment.	calphostin C	18-30	tumor necrosis factor	Bos taurus	60-63
8049080-4	1994	Coincubation of FTEC with PAF (5 microM) and pharmacologic PKC inhibitors, sphingosine, H7, or calphostin C, inhibited PAF-induced mucin secretion at 30 min.	calphostin C	95-107	protein kinase C alpha	Homo sapiens	59-62
7529661-0	1994	Light-dependent induction of early-response gene expression by calphostin-C. Calphostin-C is a compound possessing the ability to inhibit protein kinase C (PKC) by oxidative modification in vitro and to enhance the epidermal growth factor (EGF) receptor phosphorylation in vivo in a light-dependent manner.	calphostin C	77-89	epidermal growth factor receptor	Homo sapiens	215-253
7529661-1	1994	Here, we found that calphostin-C induced c-fos and c-jun mRNA accumulation in the lung adenocarcinoma cell line A549 in a light-dependent manner.	calphostin C	20-32	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	41-46
7529661-1	1994	Here, we found that calphostin-C induced c-fos and c-jun mRNA accumulation in the lung adenocarcinoma cell line A549 in a light-dependent manner.	calphostin C	20-32	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	51-56
7530592-8	1994	Insulin potentiation of NE-induced tone was suppressed by pretreatment of the rabbit facial artery with the PKC inhibitor calphostin C (0.1 microM) or the TK inhibitor genistein (10 microM).	calphostin C	122-134	insulin	Oryctolagus cuniculus	0-7
7530592-10	1994	Calphostin C (0.1 microM) and genistein (10 microM) both prevented the increase in wall force per unit of 45Ca2+ influx due to insulin (1 mU/mL).	calphostin C	0-12	insulin	Oryctolagus cuniculus	127-134
7518003-11	1994	RESULTS: 12(S)-HETE increased the motility and invasion of AT2.1 cells, and this 12(S)-HETE-increased motility and invasion were inhibited by a selective PKC inhibitor, calphostin C, as well as a Ca2 chelator, bis-(o-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid/tetra(acetoxy-methyl)ester.	calphostin C	169-181	protein kinase C, alpha	Rattus norvegicus	154-157
8049080-4	1994	Coincubation of FTEC with PAF (5 microM) and pharmacologic PKC inhibitors, sphingosine, H7, or calphostin C, inhibited PAF-induced mucin secretion at 30 min.	calphostin C	95-107	LOC100508689	Homo sapiens	131-136
7518459-4	1994	n-Chimaerin was likewise virtually indistinguishable from protein kinase C alpha in phorbol ester structure-activity relations, in phospholipid requirements, and in inhibition of binding by sphingosine and calphostin C, protein kinase C inhibitors acting on the regulatory domain.	calphostin C	206-218	chimerin 1	Homo sapiens	0-11
7527452-3	1994	Treatment of macrophages with two protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine hydrochloride (H7) and calphostin C, suppressed LPL-induced TNF alpha mRNA expression and protein production.	calphostin C	138-150	lipoprotein lipase	Mus musculus	163-166
7527452-3	1994	Treatment of macrophages with two protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine hydrochloride (H7) and calphostin C, suppressed LPL-induced TNF alpha mRNA expression and protein production.	calphostin C	138-150	tumor necrosis factor	Mus musculus	175-184
7515277-7	1994	After incubation with calphostin C, EDRF release in response to acetylcholine from lyso-PC-treated donor vessels was restored significantly.	calphostin C	22-34	alpha hemoglobin stabilizing protein	Homo sapiens	36-40
8018932-10	1994	The PKC inhibitors, 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine (H-7) and calphostin C inhibited IL-3-induced enhancement of proliferation and differentiation of ME-F1 cells, but did not inhibit enhancement of proliferation of ME-F2 cells and differentiation of ME-F3 cells.	calphostin C	78-90	interleukin 3	Homo sapiens	101-105
8018932-10	1994	The PKC inhibitors, 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine (H-7) and calphostin C inhibited IL-3-induced enhancement of proliferation and differentiation of ME-F1 cells, but did not inhibit enhancement of proliferation of ME-F2 cells and differentiation of ME-F3 cells.	calphostin C	78-90	myocyte enhancer factor 2A	Homo sapiens	231-236
8113023-6	1994	The mechanism of thrombin-induced RPE cell gap formation was studied by preincubation with specific drugs, including a protein kinase inhibitor (staurosporine), protein kinase C inhibitors (H-7 and calphostin C), cyclic adenosine monophosphate (cAMP) inducer (forskolin), and cytoskeleton-disrupting agents (cytochalasin B or colchicine).	calphostin C	198-210	coagulation factor II, thrombin	Bos taurus	17-25
8125929-5	1994	Staurosporine and calphostin C, two potent inhibitors of the serine/threonine protein kinase, protein kinase C, significantly attenuated the angiotensin II-induced eIF-4E phosphorylation.	calphostin C	18-30	angiotensinogen	Homo sapiens	141-155
8125929-5	1994	Staurosporine and calphostin C, two potent inhibitors of the serine/threonine protein kinase, protein kinase C, significantly attenuated the angiotensin II-induced eIF-4E phosphorylation.	calphostin C	18-30	eukaryotic translation initiation factor 4E	Homo sapiens	164-170
8125929-6	1994	Staurosporine and calphostin C also blunted the angiotensin II-stimulated protein synthesis.	calphostin C	18-30	angiotensinogen	Homo sapiens	48-62
7511983-6	1994	Furthermore, Calphostin C increased the uptake and decreased the efflux of rhodamine 123 (a substrate for P-gp) in P388/ADR cells but had no such effect in P388 cells.	calphostin C	13-25	phosphoglycolate phosphatase	Mus musculus	106-110
7505275-2	1994	We have found that calphostin-C induces substantial serine and threonine phosphorylation of the epidermal growth factor (EGF) receptor in a light-dependent fashion in the EGF receptor-hyperproducing squamous carcinoma cell line NA.	calphostin C	19-31	epidermal growth factor receptor	Homo sapiens	96-134
7505275-2	1994	We have found that calphostin-C induces substantial serine and threonine phosphorylation of the epidermal growth factor (EGF) receptor in a light-dependent fashion in the EGF receptor-hyperproducing squamous carcinoma cell line NA.	calphostin C	19-31	epidermal growth factor receptor	Homo sapiens	171-183
7515852-7	1994	The endothelin- and insulin-mediated increases in [3H]deoxy-D-glucose were totally ablated by treatment with calphostin C.	calphostin C	109-121	insulin	Homo sapiens	20-27
7507209-6	1994	The increased AP1 binding observed in the presence of pX was unaffected by the protein kinase C inhibitors calphostin C and sphingosine and by the protein kinase A inhibitor HA1004, while it was almost completely blocked by staurosporine, a potent and nonspecific protein kinase inhibitor, suggesting that protein kinase C- and A-independent phosphorylation events might play a role in the phenomenon.	calphostin C	107-119	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-17
7506699-7	1994	The effects of insulin were almost completely inhibited by diltiazem, staurosporine, calphostin C, and thapsigargin.	calphostin C	85-97	insulin	Homo sapiens	15-22
7510425-5	1993	Both LPS- and PMA-induced TF activity were inhibited, in a concentration dependent manner, by three different PKC inhibitors: H7, staurosporine and calphostin C.	calphostin C	148-160	coagulation factor III, tissue factor	Homo sapiens	26-28
7505275-5	1994	Staurosporine, a potent PKC inhibitor with affinity for the catalytic domain of PKC, inhibited phosphorylation of the 80 K protein and 12-O-tetradecanoyl-13-phorbol acetate induction of EGF receptor phosphorylation but did not inhibit the calphostin-C induction of the EGF receptor phosphorylation.	calphostin C	239-251	epidermal growth factor receptor	Homo sapiens	186-198
7690250-2	1993	In the present study, inhibition of protein kinase C with calphostin C or stauroporine or prolonged treatment with the phorbol ester TPA decreased phosphorylation of P-glycoprotein, and impaired transport of vinblastine.	calphostin C	58-70	ATP binding cassette subfamily B member 1	Homo sapiens	166-180
8373384-7	1993	Pretreatment with calphostin C, a specific inhibitor of protein kinase C, before straining completely abolished Et-1 mRNA expression.	calphostin C	18-30	endothelin 1	Homo sapiens	112-116
7688350-8	1993	Conversely, culturing of cells in the presence of the protein-kinase-C inhibitor, calphostin-C, led to a dose-dependent decrease in the amount of MMP-9 mRNA and protein, suggesting that the constitutive expression of this collagenase reflects activation of this signal transduction pathway.	calphostin C	82-94	matrix metallopeptidase 9	Homo sapiens	146-151
8396912-7	1993	32P labelling of MLC2 is also decreased by 50-100% following exposure to the PKC-selective inhibitors calphostin C and chelerythrine, suggesting that PKC, and not MLCK, is primarily responsible for incorporation of rapidly turning over phosphate into MLC2 in situ.	calphostin C	102-114	myosin light chain 2	Rattus norvegicus	17-21
8396912-7	1993	32P labelling of MLC2 is also decreased by 50-100% following exposure to the PKC-selective inhibitors calphostin C and chelerythrine, suggesting that PKC, and not MLCK, is primarily responsible for incorporation of rapidly turning over phosphate into MLC2 in situ.	calphostin C	102-114	protein kinase C, gamma	Rattus norvegicus	77-80
8396912-7	1993	32P labelling of MLC2 is also decreased by 50-100% following exposure to the PKC-selective inhibitors calphostin C and chelerythrine, suggesting that PKC, and not MLCK, is primarily responsible for incorporation of rapidly turning over phosphate into MLC2 in situ.	calphostin C	102-114	protein kinase C, gamma	Rattus norvegicus	150-153
7688575-4	1993	Calphostin C, a potent protein kinase C inhibitor, is able to abolish this effect of AII suggesting that the induction of preproendothelin-1 mRNA is mediated by a protein kinase C-dependent pathway.	calphostin C	0-12	angiotensinogen	Rattus norvegicus	85-88
7688575-4	1993	Calphostin C, a potent protein kinase C inhibitor, is able to abolish this effect of AII suggesting that the induction of preproendothelin-1 mRNA is mediated by a protein kinase C-dependent pathway.	calphostin C	0-12	endothelin 1	Rattus norvegicus	122-140
1281116-0	1992	Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C.	calphostin C	84-96	proline rich transmembrane protein 2	Homo sapiens	39-55
7683925-3	1993	The PKC inhibitors (H-7, staurosporine, and calphostin C), but not HA-1004, inhibited TNF-induced uPA expression, synthesis, and secretion in a dose-dependent manner.	calphostin C	44-56	proline rich transmembrane protein 2	Homo sapiens	4-7
7683925-3	1993	The PKC inhibitors (H-7, staurosporine, and calphostin C), but not HA-1004, inhibited TNF-induced uPA expression, synthesis, and secretion in a dose-dependent manner.	calphostin C	44-56	tumor necrosis factor	Homo sapiens	86-89
7683925-3	1993	The PKC inhibitors (H-7, staurosporine, and calphostin C), but not HA-1004, inhibited TNF-induced uPA expression, synthesis, and secretion in a dose-dependent manner.	calphostin C	44-56	plasminogen activator, urokinase	Homo sapiens	98-101
7683494-0	1993	Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: effect on phospholipase A2 and aggregation.	calphostin C	0-12	phospholipase A2 group IB	Homo sapiens	92-108
8508906-5	1993	Moreover, calphostin C, a specific inhibitor of protein kinase C, effectively inhibited thrombin-induced shape change, as assessed by the shape-change parameter, in a dose-dependent manner.	calphostin C	10-22	coagulation factor II, thrombin	Homo sapiens	88-96
7681061-7	1993	This hypothesis was confirmed by experiments with the PKC inhibitors staurosporine and calphostin C, which prevented the induction of IL-1 mRNA by TNF and accelerated the decay of this mRNA in cells pretreated with TNF.	calphostin C	87-99	interleukin 1 beta	Homo sapiens	134-138
7681061-7	1993	This hypothesis was confirmed by experiments with the PKC inhibitors staurosporine and calphostin C, which prevented the induction of IL-1 mRNA by TNF and accelerated the decay of this mRNA in cells pretreated with TNF.	calphostin C	87-99	tumor necrosis factor	Homo sapiens	147-150
7681061-7	1993	This hypothesis was confirmed by experiments with the PKC inhibitors staurosporine and calphostin C, which prevented the induction of IL-1 mRNA by TNF and accelerated the decay of this mRNA in cells pretreated with TNF.	calphostin C	87-99	tumor necrosis factor	Homo sapiens	215-218
8490103-6	1993	The IC50 values for the inhibition of TNF alpha production were 0.2 nM for staurosporine, and 20 nM for K252a, Calphostin C and chelerythrine.	calphostin C	111-123	tumor necrosis factor	Homo sapiens	38-47
7694083-2	1993	Treatment of Y1 cells with either staurosporine or calphostin C, inhibitors of PKC, increases steroid hormone production up to 7-fold.	calphostin C	51-63	proline rich transmembrane protein 2	Homo sapiens	79-82
8325335-6	1993	TNF-alpha secretion in response to both Nocardia fractions was inhibited by sphingosine, staurosporine and calphostin C, known PKC inhibitors, as well as by a PKC depletion procedure.	calphostin C	107-119	tumor necrosis factor	Homo sapiens	0-9
8325335-6	1993	TNF-alpha secretion in response to both Nocardia fractions was inhibited by sphingosine, staurosporine and calphostin C, known PKC inhibitors, as well as by a PKC depletion procedure.	calphostin C	107-119	proline rich transmembrane protein 2	Homo sapiens	127-130
8382972-7	1993	Moreover, TPA also inhibited DNA fragmentation induced by vinblastine, cycloheximide, calphostin C, and x-rays.	calphostin C	86-98	plasminogen activator, tissue type	Homo sapiens	10-13
8427967-7	1993	Finally, a role for protein kinase C in mediating the effects of IFN-alpha on spectrin"s organization is implicated by studies in which calphostin C inhibited the IFN-induced focal accumulation of spectrin.	calphostin C	136-148	interferon alpha 1	Homo sapiens	65-74
8430818-8	1993	The TNF-induced translocation of PKC was inhibited using either IP-300 polyclonal anti-TNF antibody (indicating that the TNF effect was not due to the vehicle or contaminating endotoxin) or calphostin C (10(-6) M for 15 min), which inhibits PKC activation by interacting with the regulatory diacylglycerol-binding domain.	calphostin C	190-202	tumor necrosis factor	Homo sapiens	4-7
8430818-8	1993	The TNF-induced translocation of PKC was inhibited using either IP-300 polyclonal anti-TNF antibody (indicating that the TNF effect was not due to the vehicle or contaminating endotoxin) or calphostin C (10(-6) M for 15 min), which inhibits PKC activation by interacting with the regulatory diacylglycerol-binding domain.	calphostin C	190-202	proline rich transmembrane protein 2	Homo sapiens	33-36
1281116-1	1992	Isolated protein kinase C (PKC) was irreversibly inactivated by a brief (min) incubation with calphostin C in the presence of light.	calphostin C	94-106	proline rich transmembrane protein 2	Homo sapiens	9-25
1281116-1	1992	Isolated protein kinase C (PKC) was irreversibly inactivated by a brief (min) incubation with calphostin C in the presence of light.	calphostin C	94-106	proline rich transmembrane protein 2	Homo sapiens	27-30
1281116-5	1992	Physical quenchers of singlet oxygen such as lycopene, beta-carotene, and alpha-tocopherol all reduced the calphostin C-induced inactivation of PKC.	calphostin C	107-119	proline rich transmembrane protein 2	Homo sapiens	144-147
1281116-6	1992	In intact cells treated with calphostin C, the inactivation of PKC was rapid in the membrane fraction compared to cytosol.	calphostin C	29-41	proline rich transmembrane protein 2	Homo sapiens	63-66
1449492-7	1992	Calphostin C, a PKC inhibitor, prevented the phorbol ester-induced increase in PKC activity and translocation.	calphostin C	0-12	protein kinase C alpha	Bos taurus	16-19
1280321-4	1992	The effect of TPA on the zona glomerulosa ANF-R1 receptors was abolished by calphostin C, a specific protein kinase C inhibitor.	calphostin C	76-88	natriuretic peptide A	Bos taurus	42-45
1282723-2	1992	The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C.	calphostin C	201-213	tumor necrosis factor	Mus musculus	4-31
1282723-2	1992	The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C.	calphostin C	201-213	tumor necrosis factor	Mus musculus	34-43
1282723-2	1992	The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C.	calphostin C	201-213	interleukin 1 complex	Mus musculus	49-68
1282723-2	1992	The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C.	calphostin C	201-213	intercellular adhesion molecule 1	Mus musculus	81-87
1384908-0	1992	Participation of protein kinase C in endothelin-1-induced contraction in rat aorta: studies with a new tool, calphostin C.	calphostin C	109-121	endothelin 1	Rattus norvegicus	37-49
1384908-5	1992	Calphostin C (10(-6) M), a selective protein kinase C inhibitor, antagonized the maximal tensions for cumulative addition of 10(-8) M ET-1 by 13.2% in Ca(2+)-containing medium and 25.8% in Ca(2+)-free Krebs containing 1 mM EGTA.	calphostin C	0-12	endothelin 1	Rattus norvegicus	134-138
1379995-6	1992	Calphostin C, a potent and selective PKC inhibitor, decreases in a dose-dependent manner the adhesion to endothelium and the lung colonization of cells from both the low and the high metastatic sub-populations with IC50 at sub-micromolar concentrations.	calphostin C	0-12	protein kinase C, gamma	Rattus norvegicus	37-40
1380299-0	1992	Protein kinase C stimulates dense tubular Ca2+ uptake in the intact human platelet by increasing the Vm of the Ca(2+)-ATPase pump: stimulation by phorbol ester, inhibition by calphostin C.	calphostin C	175-187	proline rich transmembrane protein 2	Homo sapiens	0-16
1500712-10	1992	Addition of calphostin C, a specific inhibitor of protein kinase C, 1 min prior to stimulation of resting T cells with OKT3 completely inhibited further phosphorylation of Op18.	calphostin C	12-24	stathmin 1	Homo sapiens	172-176
1322053-9	1992	Staurosporine and calphostin C, inhibitors of protein kinase C, completely blocked the decrease in Isc caused by simultaneous addition of ANF and BK.	calphostin C	18-30	natriuretic peptide A	Homo sapiens	138-141
1322053-9	1992	Staurosporine and calphostin C, inhibitors of protein kinase C, completely blocked the decrease in Isc caused by simultaneous addition of ANF and BK.	calphostin C	18-30	kininogen 1	Homo sapiens	146-148
1380299-4	1992	The activity of PKC was stimulated by phorbol 12-myristate 13-acetate (PMA) and was inhibited with calphostin C.	calphostin C	99-111	proline rich transmembrane protein 2	Homo sapiens	16-19
1375753-7	1992	This redistribution of spectrin and PKC beta is blocked by pretreatment with calphostin C, a specific inhibitor of PKC.	calphostin C	77-89	protein kinase C beta	Homo sapiens	36-44
1375753-7	1992	This redistribution of spectrin and PKC beta is blocked by pretreatment with calphostin C, a specific inhibitor of PKC.	calphostin C	77-89	proline rich transmembrane protein 2	Homo sapiens	36-39
34709697-8	2022	Treatment with PKC inhibitors (either calphostin C, chelerythrine C or rottlerin) reduced PTTH-stimulated phosphorylation of the 37-kDa protein.	calphostin C	38-50	protein kinase C	Bombyx mori	15-18
1373900-9	1992	Calphostin C, a potent PKC inhibitor, interacts with PKC in a noncompetitive manner, and it does not inhibit Ca(2+)-induced translocation of PKC.	calphostin C	0-12	protein kinase C, gamma	Rattus norvegicus	23-26
1373900-9	1992	Calphostin C, a potent PKC inhibitor, interacts with PKC in a noncompetitive manner, and it does not inhibit Ca(2+)-induced translocation of PKC.	calphostin C	0-12	protein kinase C, gamma	Rattus norvegicus	53-56
1373900-9	1992	Calphostin C, a potent PKC inhibitor, interacts with PKC in a noncompetitive manner, and it does not inhibit Ca(2+)-induced translocation of PKC.	calphostin C	0-12	protein kinase C, gamma	Rattus norvegicus	53-56
34358110-7	2021	The protein kinase C inhibitor calphostin C suppressed both the actions of PRL.	calphostin C	31-43	prolactin	Bos taurus	75-78
34299188-8	2021	LTD4 caused a significant increase in mRNA and plasma membrane protein expression of Na-K-ATPase alpha1 and beta1 subunits, which was prevented by calphostin-C.	calphostin C	147-159	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	108-113
34998939-9	2022	Blockage of putative intracellular mediators, namely phosphoinositide 3-kinase and protein kinase C (PKC) by Wortmannin and Calphostin C, respectively, revealed PKC-dependency of the pro-inhibitory IFN-gamma effect.	calphostin C	124-136	protein kinase C, gamma	Rattus norvegicus	83-99
34998939-9	2022	Blockage of putative intracellular mediators, namely phosphoinositide 3-kinase and protein kinase C (PKC) by Wortmannin and Calphostin C, respectively, revealed PKC-dependency of the pro-inhibitory IFN-gamma effect.	calphostin C	124-136	protein kinase C, gamma	Rattus norvegicus	101-104
34998939-9	2022	Blockage of putative intracellular mediators, namely phosphoinositide 3-kinase and protein kinase C (PKC) by Wortmannin and Calphostin C, respectively, revealed PKC-dependency of the pro-inhibitory IFN-gamma effect.	calphostin C	124-136	interferon gamma	Rattus norvegicus	198-207
34709697-8	2022	Treatment with PKC inhibitors (either calphostin C, chelerythrine C or rottlerin) reduced PTTH-stimulated phosphorylation of the 37-kDa protein.	calphostin C	38-50	prothoracicotropic hormone	Bombyx mori	90-94
33721446-4	2021	Besides, the cells transfected with nm23-H1 were incubated with the protein kinase C (PKC) pathway inhibitor Calphostin C, and functional experiments were performed to observe the changes in the proliferation and apoptosis of cells after incubation.	calphostin C	109-121	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	36-43
33988248-7	2021	Calphostin C, an inhibitor that disrupts diacylglycerol binding to its targets, reduces the effect PDBu and PA, but not of PA-S, suggesting that PA might interact with a well-known diacylglycerol/phorbol ester target Munc13-1.	calphostin C	0-12	unc-13 homolog A	Homo sapiens	217-225
31016764-8	2019	Pretreatment with the NMDAr antagonist MK-801 or the protein kinase C (PKC) inhibitor calphostin C (CC) suppressed the morphine-induced increase in p-ERK, p-JNK, and c-Fos.	calphostin C	86-98	protein kinase C, gamma	Mus musculus	71-74
32783140-5	2020	In contrast, treatment with Calphostin C (a nonselective PKC inhibitor) for 6 h or longer decreased ASIC1a protein expression and ASIC currents.	calphostin C	28-40	acid-sensing (proton-gated) ion channel 1	Mus musculus	100-106
32783140-5	2020	In contrast, treatment with Calphostin C (a nonselective PKC inhibitor) for 6 h or longer decreased ASIC1a protein expression and ASIC currents.	calphostin C	28-40	acid-sensing (proton-gated) ion channel 1	Mus musculus	100-104
33137935-6	2020	Directly treating HUVECs with recombinant Wnt11 protein significantly increased CLT formation, which was abrogated by treating cells with the JNK inhibitor SP600125, as well as the PKC inhibitor Calphostin-C.	calphostin C	195-207	Wnt family member 11	Homo sapiens	42-47
31016764-8	2019	Pretreatment with the NMDAr antagonist MK-801 or the protein kinase C (PKC) inhibitor calphostin C (CC) suppressed the morphine-induced increase in p-ERK, p-JNK, and c-Fos.	calphostin C	86-98	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	148-153
31016764-8	2019	Pretreatment with the NMDAr antagonist MK-801 or the protein kinase C (PKC) inhibitor calphostin C (CC) suppressed the morphine-induced increase in p-ERK, p-JNK, and c-Fos.	calphostin C	86-98	FBJ osteosarcoma oncogene	Mus musculus	166-171
30073169-9	2018	Activation of the mTORC1/S6K pathway was attenuated by 10-6 M U0126, an MEK/ERK inhibitor, and 10-6 M calphostin C, a PKC inhibitor, indicating that the MEK/ERK/TSC2 axis acts as a mediator.	calphostin C	102-114	CREB regulated transcription coactivator 1	Mus musculus	18-24
30883902-6	2019	VEGF increased phosphorylation of PKCalpha and AMPA receptor subunit GluA2 in astrocytes, and these effects were diminished by SU1498 or calphostin C, a PKC inhibitor.	calphostin C	137-149	vascular endothelial growth factor A	Homo sapiens	0-4
30883902-6	2019	VEGF increased phosphorylation of PKCalpha and AMPA receptor subunit GluA2 in astrocytes, and these effects were diminished by SU1498 or calphostin C, a PKC inhibitor.	calphostin C	137-149	protein kinase C alpha	Homo sapiens	34-42
30883902-6	2019	VEGF increased phosphorylation of PKCalpha and AMPA receptor subunit GluA2 in astrocytes, and these effects were diminished by SU1498 or calphostin C, a PKC inhibitor.	calphostin C	137-149	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	69-74
30921339-8	2019	In contrast, PKC inhibitors calphostin C, Go6976, sotrastaurin and ruboxistaurin suppressed FGF23 formation.	calphostin C	28-40	protein kinase C, gamma	Rattus norvegicus	13-16
30921339-8	2019	In contrast, PKC inhibitors calphostin C, Go6976, sotrastaurin and ruboxistaurin suppressed FGF23 formation.	calphostin C	28-40	fibroblast growth factor 23	Rattus norvegicus	92-97
31502430-11	2019	Inhibiting PKC and ERK with respectively calphostin C and PD98059 abolished the effect of FTY720-P on the ATPase and on IkappaB, but not that of exogenous PGE2 indicating that the two kinases are upstream of NF-kappaB and PGE2.	calphostin C	41-53	mitogen-activated protein kinase 1	Homo sapiens	19-22
31502430-11	2019	Inhibiting PKC and ERK with respectively calphostin C and PD98059 abolished the effect of FTY720-P on the ATPase and on IkappaB, but not that of exogenous PGE2 indicating that the two kinases are upstream of NF-kappaB and PGE2.	calphostin C	41-53	nuclear factor kappa B subunit 1	Homo sapiens	208-217
31393950-6	2019	Treatment with calphostin C, PTIO, ODQ or KT5823, respective inhibitors of PKC, NO, soluble guanylate cyclase and PKG, abrogated completely the effect of epinephrine and PGE2, suggesting an involvement of these mediators.	calphostin C	15-27	proline rich transmembrane protein 2	Homo sapiens	75-78
31393950-6	2019	Treatment with calphostin C, PTIO, ODQ or KT5823, respective inhibitors of PKC, NO, soluble guanylate cyclase and PKG, abrogated completely the effect of epinephrine and PGE2, suggesting an involvement of these mediators.	calphostin C	15-27	protein kinase cGMP-dependent 1	Homo sapiens	114-117
30073169-9	2018	Activation of the mTORC1/S6K pathway was attenuated by 10-6 M U0126, an MEK/ERK inhibitor, and 10-6 M calphostin C, a PKC inhibitor, indicating that the MEK/ERK/TSC2 axis acts as a mediator.	calphostin C	102-114	ribosomal protein S6 kinase B1	Homo sapiens	25-28
30073169-9	2018	Activation of the mTORC1/S6K pathway was attenuated by 10-6 M U0126, an MEK/ERK inhibitor, and 10-6 M calphostin C, a PKC inhibitor, indicating that the MEK/ERK/TSC2 axis acts as a mediator.	calphostin C	102-114	mitogen-activated protein kinase kinase 7	Homo sapiens	153-156
30073169-9	2018	Activation of the mTORC1/S6K pathway was attenuated by 10-6 M U0126, an MEK/ERK inhibitor, and 10-6 M calphostin C, a PKC inhibitor, indicating that the MEK/ERK/TSC2 axis acts as a mediator.	calphostin C	102-114	mitogen-activated protein kinase 1	Homo sapiens	157-160
27771709-9	2016	RESULTS: The percentage of RBCs showing PS exposure after activation with LPA, PMA, or A23187 is significantly reduced after inhibition of the scramblase using the specific inhibitor R5421 as well as after the inhibition of the PKCalpha using chelerythrine chloride or calphostin C.	calphostin C	269-281	protein kinase C alpha	Homo sapiens	228-236