PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33323305-6 2021 In TNF-alpha-stimulated HaCaT cells, QNZ and JSH-23 (NFkappaB inhibitors) blocked ZnO NP-induced inflammation. zno np 82-88 tumor necrosis factor Homo sapiens 3-12 34797187-13 2021 CONCLUSION: High concentration of ZnO NP caused toxicity to HGF-1 cells and inhibited cell proliferation by regulating MDM2 and p53 expression. zno np 34-40 MDM2 proto-oncogene Homo sapiens 119-123 34797187-13 2021 CONCLUSION: High concentration of ZnO NP caused toxicity to HGF-1 cells and inhibited cell proliferation by regulating MDM2 and p53 expression. zno np 34-40 tumor protein p53 Homo sapiens 128-131 35448455-6 2022 SOD, 8-OHdG, and acetylcholinesterase (AChE) levels in the brain were decreased after ZnO NP administration. zno np 86-92 acetylcholinesterase Rattus norvegicus 17-37 35448455-6 2022 SOD, 8-OHdG, and acetylcholinesterase (AChE) levels in the brain were decreased after ZnO NP administration. zno np 86-92 acetylcholinesterase Rattus norvegicus 39-43 35448455-7 2022 The brain levels of beclin-1 and caspase-3 were elevated after ZnO NP treatment, and these effects were significantly ameliorated by esculetin and fucoidan. zno np 63-69 beclin 1 Rattus norvegicus 20-28 35448455-7 2022 The brain levels of beclin-1 and caspase-3 were elevated after ZnO NP treatment, and these effects were significantly ameliorated by esculetin and fucoidan. zno np 63-69 caspase 3 Rattus norvegicus 33-42 35448455-8 2022 The number of reactive astrocytes measured by counting glial fibrillary acidic protein (GFAP)-positive cells, but not microglia, increased following ZnO NP treatment, and esculetin and fucoidan ameliorated the changes. zno np 149-155 glial fibrillary acidic protein Rattus norvegicus 55-86 35448455-8 2022 The number of reactive astrocytes measured by counting glial fibrillary acidic protein (GFAP)-positive cells, but not microglia, increased following ZnO NP treatment, and esculetin and fucoidan ameliorated the changes. zno np 149-155 glial fibrillary acidic protein Rattus norvegicus 88-92 35448455-5 2022 Brain IL-1beta and TNF-alpha levels were elevated after ZnO NP administration, and these effects were inhibited by esculetin and fucoidan. zno np 56-62 interleukin 1 alpha Rattus norvegicus 6-14 35448455-5 2022 Brain IL-1beta and TNF-alpha levels were elevated after ZnO NP administration, and these effects were inhibited by esculetin and fucoidan. zno np 56-62 tumor necrosis factor Rattus norvegicus 19-28 35099326-13 2022 CONCLUSION: High concentration of ZnO NP caused toxicity to HGF-1 cells and inhibited cell proliferation by regulating MDM2 and p53 expression. zno np 34-40 MDM2 proto-oncogene Homo sapiens 119-123 35099326-13 2022 CONCLUSION: High concentration of ZnO NP caused toxicity to HGF-1 cells and inhibited cell proliferation by regulating MDM2 and p53 expression. zno np 34-40 tumor protein p53 Homo sapiens 128-131 33323305-6 2021 In TNF-alpha-stimulated HaCaT cells, QNZ and JSH-23 (NFkappaB inhibitors) blocked ZnO NP-induced inflammation. zno np 82-88 nuclear factor kappa B subunit 1 Homo sapiens 53-61 31330912-4 2019 Apoptosis induced by ZnO NP exposure was confirmed by the elevation of caspase-3/7 activity and 4",6"-diamidino-2-phenylindole (DAPI) staining. zno np 21-27 caspase 3 Homo sapiens 71-80 32294608-11 2020 Inhaling ZnO NP at the higher concentration increased the levels of mRNA of the following genes in the lungs: Mt2 (2.56 fold), Slc30a1 (1.52 fold) and Slc30a5 (2.34 fold). zno np 9-15 solute carrier family 30 (zinc transporter), member 1 Mus musculus 127-134 32294608-11 2020 Inhaling ZnO NP at the higher concentration increased the levels of mRNA of the following genes in the lungs: Mt2 (2.56 fold), Slc30a1 (1.52 fold) and Slc30a5 (2.34 fold). zno np 9-15 solute carrier family 30 (zinc transporter), member 5 Mus musculus 151-158 31771091-5 2019 A variety of cell culture studies have shown that ZnO NP can induce cytokines such as IFN-gamma, TNF-alpha, IL-2, and IL-12 which are known to regulate the tumor microenvironment. zno np 50-56 interferon gamma Homo sapiens 86-95 31771091-5 2019 A variety of cell culture studies have shown that ZnO NP can induce cytokines such as IFN-gamma, TNF-alpha, IL-2, and IL-12 which are known to regulate the tumor microenvironment. zno np 50-56 tumor necrosis factor Homo sapiens 97-106 31771091-5 2019 A variety of cell culture studies have shown that ZnO NP can induce cytokines such as IFN-gamma, TNF-alpha, IL-2, and IL-12 which are known to regulate the tumor microenvironment. zno np 50-56 interleukin 2 Homo sapiens 108-112 33683276-7 2021 Furthermore, we proved that VPS34 transferred from cell cytoplasm to cell membrane to interact with dynamin under ZnO NP treatment. zno np 114-120 phosphatidylinositol 3-kinase catalytic subunit type 3 Homo sapiens 28-33 33299310-6 2020 Clearly increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were observed in the 610 mg/kg ZnO NP group (P>0.05), whereas alkaline phosphatase (ALP) increased in the 610 mg/kg ZnO NP group (P<0.05). zno np 124-130 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 18-44 33299310-6 2020 Clearly increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were observed in the 610 mg/kg ZnO NP group (P>0.05), whereas alkaline phosphatase (ALP) increased in the 610 mg/kg ZnO NP group (P<0.05). zno np 124-130 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 46-49 33299310-7 2020 Significant differences in insulin-like growth factor type 1 (IGF-1) levels and a decrease in calcium (Ca) levels were observed in 203 and 610 mg/kg ZnO NP groups (P<0.05). zno np 149-155 insulin-like growth factor 1 Rattus norvegicus 27-60 33299310-7 2020 Significant differences in insulin-like growth factor type 1 (IGF-1) levels and a decrease in calcium (Ca) levels were observed in 203 and 610 mg/kg ZnO NP groups (P<0.05). zno np 149-155 insulin-like growth factor 1 Rattus norvegicus 62-67 33299310-11 2020 Osteoprotegerin (OPG) expression and the ratio of OPG to receptor activator of nuclear factor-kappaB ligand (RANKL) were statistically lower in the 610 mg/kg ZnO NP group (P<0.05), whereas RANKL expression did not change significantly (P>0.05). zno np 158-164 TNF receptor superfamily member 11B Rattus norvegicus 0-15 33299310-11 2020 Osteoprotegerin (OPG) expression and the ratio of OPG to receptor activator of nuclear factor-kappaB ligand (RANKL) were statistically lower in the 610 mg/kg ZnO NP group (P<0.05), whereas RANKL expression did not change significantly (P>0.05). zno np 158-164 TNF receptor superfamily member 11B Rattus norvegicus 17-20 33299310-11 2020 Osteoprotegerin (OPG) expression and the ratio of OPG to receptor activator of nuclear factor-kappaB ligand (RANKL) were statistically lower in the 610 mg/kg ZnO NP group (P<0.05), whereas RANKL expression did not change significantly (P>0.05). zno np 158-164 TNF receptor superfamily member 11B Rattus norvegicus 50-53 33299310-11 2020 Osteoprotegerin (OPG) expression and the ratio of OPG to receptor activator of nuclear factor-kappaB ligand (RANKL) were statistically lower in the 610 mg/kg ZnO NP group (P<0.05), whereas RANKL expression did not change significantly (P>0.05). zno np 158-164 TNF superfamily member 11 Rattus norvegicus 57-107 33299310-11 2020 Osteoprotegerin (OPG) expression and the ratio of OPG to receptor activator of nuclear factor-kappaB ligand (RANKL) were statistically lower in the 610 mg/kg ZnO NP group (P<0.05), whereas RANKL expression did not change significantly (P>0.05). zno np 158-164 TNF superfamily member 11 Rattus norvegicus 109-114 33299310-11 2020 Osteoprotegerin (OPG) expression and the ratio of OPG to receptor activator of nuclear factor-kappaB ligand (RANKL) were statistically lower in the 610 mg/kg ZnO NP group (P<0.05), whereas RANKL expression did not change significantly (P>0.05). zno np 158-164 TNF superfamily member 11 Rattus norvegicus 189-194 31220582-4 2019 Here we reported that ZnO NP treatment dramatically induced the expression of ATF3 in human bronchial epithelial (HBE) cells, which was mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2). zno np 22-28 activating transcription factor 3 Homo sapiens 78-82 31220582-4 2019 Here we reported that ZnO NP treatment dramatically induced the expression of ATF3 in human bronchial epithelial (HBE) cells, which was mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2). zno np 22-28 NFE2 like bZIP transcription factor 2 Homo sapiens 152-195 31220582-4 2019 Here we reported that ZnO NP treatment dramatically induced the expression of ATF3 in human bronchial epithelial (HBE) cells, which was mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2). zno np 22-28 NFE2 like bZIP transcription factor 2 Homo sapiens 197-201 31220582-5 2019 ATF3 was required for the repair of ZnO NP-induced DNA damage as gamma foci number increased when endogenous ATF3 was silenced. zno np 36-42 activating transcription factor 3 Homo sapiens 0-4 31220582-5 2019 ATF3 was required for the repair of ZnO NP-induced DNA damage as gamma foci number increased when endogenous ATF3 was silenced. zno np 36-42 activating transcription factor 3 Homo sapiens 109-113 31220582-7 2019 Mechanistic study revealed that ATF3 interacted with the p53 protein and upregulated its expression under ZnO NP treatment. zno np 106-112 activating transcription factor 3 Homo sapiens 32-36 31220582-7 2019 Mechanistic study revealed that ATF3 interacted with the p53 protein and upregulated its expression under ZnO NP treatment. zno np 106-112 tumor protein p53 Homo sapiens 57-60 31220582-8 2019 Collectively, our findings demonstrated ATF3 as an important regulator of epithelial homeostasis by promoting both DNA repair and the death of damaged cells under ZnO NP-induced genotoxic stress. zno np 163-169 activating transcription factor 3 Homo sapiens 40-44 31330912-8 2019 Inhibitors of cyclooxygenase-2 and lipoxygenase attenuated ZnO NP-induced toxicity. zno np 59-65 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-47 30340083-7 2019 Moreover, the expression of XBP-1s, HSPA5, CASP9, CASP12, BAX and ATG7 in pristine ZnO NP-exposed co-culture was significantly lower than that in hydrophobic ZnO NP-exposed co-culture (p < 0.05). zno np 83-89 caspase 9 Homo sapiens 43-48 30922967-5 2019 However, the intracellular superoxide, Zn ions, or release of interleukin-8 after ZnO NP exposure were not significantly affected by the presence of CC. zno np 82-88 C-X-C motif chemokine ligand 8 Homo sapiens 62-75 30340083-7 2019 Moreover, the expression of XBP-1s, HSPA5, CASP9, CASP12, BAX and ATG7 in pristine ZnO NP-exposed co-culture was significantly lower than that in hydrophobic ZnO NP-exposed co-culture (p < 0.05). zno np 83-89 autophagy related 7 Homo sapiens 66-70 30340083-7 2019 Moreover, the expression of XBP-1s, HSPA5, CASP9, CASP12, BAX and ATG7 in pristine ZnO NP-exposed co-culture was significantly lower than that in hydrophobic ZnO NP-exposed co-culture (p < 0.05). zno np 83-89 caspase 12 (gene/pseudogene) Homo sapiens 50-56 30340083-7 2019 Moreover, the expression of XBP-1s, HSPA5, CASP9, CASP12, BAX and ATG7 in pristine ZnO NP-exposed co-culture was significantly lower than that in hydrophobic ZnO NP-exposed co-culture (p < 0.05). zno np 83-89 BCL2 associated X, apoptosis regulator Homo sapiens 58-61 28331313-5 2017 Here, a PINK1 gene knockdown BV-2 cell model was established to determine whether PINK1/parkin-mediated mitophagy was involved in ZnO NP-induced toxicity in BV-2 cells. zno np 130-136 PTEN induced putative kinase 1 Mus musculus 82-87 29783874-10 2018 Combined, these results suggested that pre-incubation with BSA could modestly alleviate the cytotoxicity and reduce ER stress related apoptosis gene expression in THP-1 macrophages after ZnO NP exposure. zno np 187-193 GLI family zinc finger 2 Homo sapiens 163-168 29691881-8 2018 The expression of apoptotic genes BAX and CASP3 was significantly induced by ZnO NP exposure after 3 and 5 hours, respectively, and H3 further significantly promoted CASP3 expression at 5 hours. zno np 77-83 BCL2 associated X, apoptosis regulator Homo sapiens 34-37 29691881-8 2018 The expression of apoptotic genes BAX and CASP3 was significantly induced by ZnO NP exposure after 3 and 5 hours, respectively, and H3 further significantly promoted CASP3 expression at 5 hours. zno np 77-83 caspase 3 Homo sapiens 42-47 29691881-8 2018 The expression of apoptotic genes BAX and CASP3 was significantly induced by ZnO NP exposure after 3 and 5 hours, respectively, and H3 further significantly promoted CASP3 expression at 5 hours. zno np 77-83 caspase 3 Homo sapiens 166-171 28919752-7 2017 ZnO NP-treated cells showed upregulation of p53 and LC3, indicating that ZnO NPs are able to upregulate apoptosis and autophagy. zno np 0-6 tumor protein p53 Homo sapiens 44-47 28919752-7 2017 ZnO NP-treated cells showed upregulation of p53 and LC3, indicating that ZnO NPs are able to upregulate apoptosis and autophagy. zno np 0-6 microtubule associated protein 1 light chain 3 alpha Homo sapiens 52-55 26364578-5 2015 Apoptotic injury-as measured by annexin V and caspase 3/7 activities-was significantly elevated at 12 h and 24 h, but not 6 h, after ZnO NP exposure. zno np 133-139 annexin A5 Homo sapiens 32-41 26364578-5 2015 Apoptotic injury-as measured by annexin V and caspase 3/7 activities-was significantly elevated at 12 h and 24 h, but not 6 h, after ZnO NP exposure. zno np 133-139 caspase 3 Homo sapiens 46-55 26364578-8 2015 The elevation of PI3 kinase (PI3K) and p-Akt/Akt activities induced by ZnO NP was significantly decreased by esculetin or LY294002. zno np 71-77 AKT serine/threonine kinase 1 Homo sapiens 41-44 26364578-8 2015 The elevation of PI3 kinase (PI3K) and p-Akt/Akt activities induced by ZnO NP was significantly decreased by esculetin or LY294002. zno np 71-77 AKT serine/threonine kinase 1 Homo sapiens 45-48 25565837-10 2014 Consistently, serum levels of pro/anti-inflammatory (interleukin [IL]-1beta, tumor necrosis factor-alpha, and IL-10) and T helper-1 cytokines (interferon-gamma and IL-12p70) in ZnO NP-fed mice were significantly suppressed. zno np 177-183 tumor necrosis factor Mus musculus 53-104 25378273-11 2015 Accordingly, ZnO NP-mediated upregulation of LC3A and induction of immune cell death were inhibited by blocking autophagy and ROS production. zno np 13-19 microtubule-associated protein 1 light chain 3 alpha Mus musculus 45-49 25645871-6 2015 RESULTS: Exposure to sub-cytotoxic ZnO NP concentrations (20 mug/mL) induced significant up-regulation of mRNA for the pro-inflammatory cytokine IL-8 and redox stress marker heme oxygenase-1, along with increased release of IL-8. zno np 35-41 chemokine (C-X-C motif) ligand 15 Mus musculus 145-149 25645871-6 2015 RESULTS: Exposure to sub-cytotoxic ZnO NP concentrations (20 mug/mL) induced significant up-regulation of mRNA for the pro-inflammatory cytokine IL-8 and redox stress marker heme oxygenase-1, along with increased release of IL-8. zno np 35-41 heme oxygenase 1 Mus musculus 174-190 25645871-6 2015 RESULTS: Exposure to sub-cytotoxic ZnO NP concentrations (20 mug/mL) induced significant up-regulation of mRNA for the pro-inflammatory cytokine IL-8 and redox stress marker heme oxygenase-1, along with increased release of IL-8. zno np 35-41 chemokine (C-X-C motif) ligand 15 Mus musculus 224-228 24624962-4 2014 ZnO NP exposure was found to reduce cell viability in MTT assays, increase lactate dehydrogenase (LDH) release, stimulate intracellular reactive oxygen species (ROS) generation, and elicit caspase-3 activation in a dose- and time-dependent manner. zno np 0-6 caspase 3 Homo sapiens 189-198 24624962-8 2014 Moreover, JNK inhibitor (SP600125) significantly reduced ZnO NP-induced cleaved PARP and cleaved caspase-3 expression, but not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), indicating that JNK signaling pathway is involved in ZnO NP-induced apoptosis in primary astrocytes. zno np 57-63 mitogen-activated protein kinase 8 Homo sapiens 10-13 24624962-8 2014 Moreover, JNK inhibitor (SP600125) significantly reduced ZnO NP-induced cleaved PARP and cleaved caspase-3 expression, but not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), indicating that JNK signaling pathway is involved in ZnO NP-induced apoptosis in primary astrocytes. zno np 57-63 poly(ADP-ribose) polymerase 1 Homo sapiens 80-84 24624962-8 2014 Moreover, JNK inhibitor (SP600125) significantly reduced ZnO NP-induced cleaved PARP and cleaved caspase-3 expression, but not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), indicating that JNK signaling pathway is involved in ZnO NP-induced apoptosis in primary astrocytes. zno np 57-63 caspase 3 Homo sapiens 97-106 24624962-8 2014 Moreover, JNK inhibitor (SP600125) significantly reduced ZnO NP-induced cleaved PARP and cleaved caspase-3 expression, but not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), indicating that JNK signaling pathway is involved in ZnO NP-induced apoptosis in primary astrocytes. zno np 57-63 mitogen-activated protein kinase 8 Homo sapiens 199-202 24624962-8 2014 Moreover, JNK inhibitor (SP600125) significantly reduced ZnO NP-induced cleaved PARP and cleaved caspase-3 expression, but not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), indicating that JNK signaling pathway is involved in ZnO NP-induced apoptosis in primary astrocytes. zno np 236-242 mitogen-activated protein kinase 8 Homo sapiens 10-13 24624962-5 2014 Apoptosis occurred after ZnO NP exposure as evidenced by nuclear condensation and poly(ADP-ribose) polymerase-1 (PARP) cleavage. zno np 25-31 poly(ADP-ribose) polymerase 1 Homo sapiens 82-111 24624962-5 2014 Apoptosis occurred after ZnO NP exposure as evidenced by nuclear condensation and poly(ADP-ribose) polymerase-1 (PARP) cleavage. zno np 25-31 poly(ADP-ribose) polymerase 1 Homo sapiens 113-117 24624962-6 2014 A decrease in mitochondrial membrane potential (MMP) with a concomitant increase in the expression of Bax/Bcl-2 ratio suggested that the mitochondria also mediated the pathway involved in ZnO NP-induced apoptosis. zno np 188-194 BCL2 associated X, apoptosis regulator Homo sapiens 102-105 24624962-6 2014 A decrease in mitochondrial membrane potential (MMP) with a concomitant increase in the expression of Bax/Bcl-2 ratio suggested that the mitochondria also mediated the pathway involved in ZnO NP-induced apoptosis. zno np 188-194 BCL2 apoptosis regulator Homo sapiens 106-111 22393286-7 2012 Both the mRNA and protein levels of tumor suppressor gene p53 and apoptotic gene bax were upregulated while the antiapoptotic gene bcl-2 was downregulated in ZnO NP-treated HepG2 cells. zno np 158-164 tumor protein p53 Homo sapiens 58-61 22393286-7 2012 Both the mRNA and protein levels of tumor suppressor gene p53 and apoptotic gene bax were upregulated while the antiapoptotic gene bcl-2 was downregulated in ZnO NP-treated HepG2 cells. zno np 158-164 BCL2 associated X, apoptosis regulator Homo sapiens 81-84 22393286-7 2012 Both the mRNA and protein levels of tumor suppressor gene p53 and apoptotic gene bax were upregulated while the antiapoptotic gene bcl-2 was downregulated in ZnO NP-treated HepG2 cells. zno np 158-164 BCL2 apoptosis regulator Homo sapiens 131-136