PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32698250-3	2021	CYP27A1 and CYP46A1 are the major oxysterol-producing enzymes in the retina that convert cholesterol to 27- and 24-hydroxycholesterol, respectively.	Oxysterols	34-43	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	0-7
32698250-3	2021	CYP27A1 and CYP46A1 are the major oxysterol-producing enzymes in the retina that convert cholesterol to 27- and 24-hydroxycholesterol, respectively.	Oxysterols	34-43	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	12-19
32616181-2	2020	HMGCR is subject to layers of negative feedback loops; excess cholesterol inhibits transcription of the gene, and lanosterols and oxysterols accelerate degradation of HMGCR.	Oxysterols	130-140	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	0-5
32616181-2	2020	HMGCR is subject to layers of negative feedback loops; excess cholesterol inhibits transcription of the gene, and lanosterols and oxysterols accelerate degradation of HMGCR.	Oxysterols	130-140	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	167-172
32616181-4	2020	Although genetic and biochemical studies revealed that the accelerated degradation requires the membrane domain of HMGCR and Insig, an oxysterol sensor on the endoplasmic reticulum membrane, the direct target of the bisphosphonate esters remains unclear.	Oxysterols	135-144	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	115-120
32587660-9	2020	Results: Serum nitrotyrosine, IL-1beta, and TNF-alpha concentrations as well as TNF-alpha content in the liver were significantly higher in both groups exposed to oxysterols (ECh and ES groups) as compared to the C group.	Oxysterols	163-173	tumor necrosis factor	Rattus norvegicus	80-89
32640529-2	2020	Cholesterol-25-hydroxylase (CH25H) and its enzymatic products 25-hydroxycholesterol (25HC), a well-known oxysterol that regulates lipid metabolism, have been reported to play multiple functions in modulating cholesterol homeostasis, inflammation, and immune responses.	Oxysterols	105-114	cholesterol 25-hydroxylase	Homo sapiens	0-26
32640529-2	2020	Cholesterol-25-hydroxylase (CH25H) and its enzymatic products 25-hydroxycholesterol (25HC), a well-known oxysterol that regulates lipid metabolism, have been reported to play multiple functions in modulating cholesterol homeostasis, inflammation, and immune responses.	Oxysterols	105-114	cholesterol 25-hydroxylase	Homo sapiens	28-33
32621622-4	2021	During both development and in later life, oxysterols and other sterols interact with a variety of different receptors, including nuclear receptors, membrane bound G protein-coupled receptors, the oxysterol/sterol sensing proteins INSIG and SCAP, and the ligand-gated ion channel N-methyl-D-aspartate receptors found in nerve cells.	Oxysterols	43-53	SREBF chaperone	Homo sapiens	241-245
32621622-4	2021	During both development and in later life, oxysterols and other sterols interact with a variety of different receptors, including nuclear receptors, membrane bound G protein-coupled receptors, the oxysterol/sterol sensing proteins INSIG and SCAP, and the ligand-gated ion channel N-methyl-D-aspartate receptors found in nerve cells.	Oxysterols	43-52	SREBF chaperone	Homo sapiens	241-245
32570981-1	2020	Oxysterol binding related proteins 5 and 8 (ORP5 and ORP8) are two close homologs of the larger oxysterol binding protein (OSBP) family of sterol sensors and lipid transfer proteins (LTP).	Oxysterols	0-9	oxysterol binding protein like 5	Homo sapiens	44-48
32570981-1	2020	Oxysterol binding related proteins 5 and 8 (ORP5 and ORP8) are two close homologs of the larger oxysterol binding protein (OSBP) family of sterol sensors and lipid transfer proteins (LTP).	Oxysterols	0-9	oxysterol binding protein like 8	Homo sapiens	53-57
32570981-1	2020	Oxysterol binding related proteins 5 and 8 (ORP5 and ORP8) are two close homologs of the larger oxysterol binding protein (OSBP) family of sterol sensors and lipid transfer proteins (LTP).	Oxysterols	0-9	oxysterol binding protein	Homo sapiens	96-121
32570981-1	2020	Oxysterol binding related proteins 5 and 8 (ORP5 and ORP8) are two close homologs of the larger oxysterol binding protein (OSBP) family of sterol sensors and lipid transfer proteins (LTP).	Oxysterols	0-9	oxysterol binding protein	Homo sapiens	123-127
31427180-1	2020	BACKGROUND: The present study has the objective to assess the zinc (Zn), copper (Cu), and oxysterols plasma levels in type 1 (DM1) (n = 26) and type 2 (DM2) (n = 80) diabetes patients, as compared to healthy controls (n = 71), in order to testify whether metal levels may have a significant impact on the association between oxysterols and diabetes.	Oxysterols	90-100	immunoglobulin heavy diversity 1-7	Homo sapiens	126-129
32432943-2	2021	However, the current known SCAP inhibitors, such as oxysterols, induce endoplasmic reticulum (ER) stress and NR1H3/LXRalpha (nuclear receptor subfamily 1 group H member 3)-SREBF1/SREBP-1 c-mediated hepatic steatosis, which severely limited the clinical application of this inhibitor.	Oxysterols	52-62	SREBF chaperone	Mus musculus	27-31
32432943-2	2021	However, the current known SCAP inhibitors, such as oxysterols, induce endoplasmic reticulum (ER) stress and NR1H3/LXRalpha (nuclear receptor subfamily 1 group H member 3)-SREBF1/SREBP-1 c-mediated hepatic steatosis, which severely limited the clinical application of this inhibitor.	Oxysterols	52-62	nuclear receptor subfamily 1, group H, member 3	Mus musculus	109-114
32432943-2	2021	However, the current known SCAP inhibitors, such as oxysterols, induce endoplasmic reticulum (ER) stress and NR1H3/LXRalpha (nuclear receptor subfamily 1 group H member 3)-SREBF1/SREBP-1 c-mediated hepatic steatosis, which severely limited the clinical application of this inhibitor.	Oxysterols	52-62	nuclear receptor subfamily 1, group H, member 3	Mus musculus	115-123
32432943-2	2021	However, the current known SCAP inhibitors, such as oxysterols, induce endoplasmic reticulum (ER) stress and NR1H3/LXRalpha (nuclear receptor subfamily 1 group H member 3)-SREBF1/SREBP-1 c-mediated hepatic steatosis, which severely limited the clinical application of this inhibitor.	Oxysterols	52-62	nuclear receptor subfamily 1, group H, member 3	Mus musculus	125-170
32432943-2	2021	However, the current known SCAP inhibitors, such as oxysterols, induce endoplasmic reticulum (ER) stress and NR1H3/LXRalpha (nuclear receptor subfamily 1 group H member 3)-SREBF1/SREBP-1 c-mediated hepatic steatosis, which severely limited the clinical application of this inhibitor.	Oxysterols	52-62	sterol regulatory element binding transcription factor 1	Mus musculus	172-178
32432943-2	2021	However, the current known SCAP inhibitors, such as oxysterols, induce endoplasmic reticulum (ER) stress and NR1H3/LXRalpha (nuclear receptor subfamily 1 group H member 3)-SREBF1/SREBP-1 c-mediated hepatic steatosis, which severely limited the clinical application of this inhibitor.	Oxysterols	52-62	sterol regulatory element binding transcription factor 1	Mus musculus	179-188
32443626-7	2020	We also demonstrate that the role of liver NAPE-PLD goes beyond the mere synthesis of NAEs, since the deletion of NAPE-PLD is associated with a marked modification of various bioactive lipids involved in host homeostasis such as oxysterols and bile acids.	Oxysterols	229-239	N-acyl phosphatidylethanolamine phospholipase D	Mus musculus	43-51
32443626-7	2020	We also demonstrate that the role of liver NAPE-PLD goes beyond the mere synthesis of NAEs, since the deletion of NAPE-PLD is associated with a marked modification of various bioactive lipids involved in host homeostasis such as oxysterols and bile acids.	Oxysterols	229-239	N-acyl phosphatidylethanolamine phospholipase D	Mus musculus	114-122
32292343-4	2020	We measured oxysterols in serum of volunteers dosed with PXR agonist rifampicin 600 mg/day versus placebo for a week and analyzed the expression of cholesterol transporters in mononuclear cells.	Oxysterols	12-22	nuclear receptor subfamily 1 group I member 2	Homo sapiens	57-60
31541728-0	2019	Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse.	Oxysterols	28-38	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	155-162
31386594-2	2020	Various endogenous and synthetic RORgamma (inverse) agonists have been identified that regulate RORgamma transcriptional activity, including many cholesterol intermediates and oxysterols.	Oxysterols	176-186	RAR-related orphan receptor gamma	Mus musculus	33-41
30716465-5	2019	Its OSBP-related domain binds cholesterol, oxysterols, and phosphoinositides, and its overexpression enhances cellular cholesterol efflux.	Oxysterols	43-53	oxysterol binding protein	Homo sapiens	4-8
31580889-0	2019	Side-chain oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase and 3-hydroxy-3-methylglutaryl-CoA reductase by inhibiting the interaction of p300 and NF-Y, and H3K27 acetylation.	Oxysterols	11-21	solute carrier family 25 member 1	Homo sapiens	52-103
31580889-0	2019	Side-chain oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase and 3-hydroxy-3-methylglutaryl-CoA reductase by inhibiting the interaction of p300 and NF-Y, and H3K27 acetylation.	Oxysterols	11-21	E1A binding protein p300	Homo sapiens	176-180
31580889-11	2019	Based on these results, we concluded that 25-HC (and other side-chain oxysterols) in the medium was easily transferred into cells, suppressed H3K27 acetylation via p300 recruitment on the NF-Y complex in the Pcyt2 and Hmgcr promoters, and then suppressed transcription of these genes although LXR is not involved.	Oxysterols	70-80	E1A binding protein p300	Homo sapiens	164-168
31580889-11	2019	Based on these results, we concluded that 25-HC (and other side-chain oxysterols) in the medium was easily transferred into cells, suppressed H3K27 acetylation via p300 recruitment on the NF-Y complex in the Pcyt2 and Hmgcr promoters, and then suppressed transcription of these genes although LXR is not involved.	Oxysterols	70-80	phosphate cytidylyltransferase 2, ethanolamine	Homo sapiens	208-213
31580889-11	2019	Based on these results, we concluded that 25-HC (and other side-chain oxysterols) in the medium was easily transferred into cells, suppressed H3K27 acetylation via p300 recruitment on the NF-Y complex in the Pcyt2 and Hmgcr promoters, and then suppressed transcription of these genes although LXR is not involved.	Oxysterols	70-80	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	218-223
31400393-3	2019	In a previous publication we reported that oxysterols with a shorter side chain (C24) modulate the DAF-12 receptor activity either as partial agonists or, in the case of the C24 alcohol 24-hydroxy-4-cholen-3-one, as an antagonist both in vitro and in vivo.	Oxysterols	43-53	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	99-105
31220227-0	2019	The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.	Oxysterols	4-13	cholesterol 25-hydroxylase	Homo sapiens	34-39
31382484-7	2019	Lipid subclass analyses revealed various oxysterols, sphingomyelins, and ceramides, species uniquely enriched in human plaques were significantly reduced by cholesterol acceptors, especially by apoA-I.	Oxysterols	41-51	apolipoprotein A1	Homo sapiens	194-200
31451509-4	2019	Oxysterol-related binding proteins ORP5 and ORP8 exchange PtdSer synthesized in the ER for phosphatidyl-4-phosphate synthesized in the PM.	Oxysterols	0-9	oxysterol binding protein like 5	Homo sapiens	35-39
31451509-4	2019	Oxysterol-related binding proteins ORP5 and ORP8 exchange PtdSer synthesized in the ER for phosphatidyl-4-phosphate synthesized in the PM.	Oxysterols	0-9	oxysterol binding protein like 8	Homo sapiens	44-48
31039009-0	2019	Hepatic MyD88 regulates liver inflammation by altering synthesis of oxysterols.	Oxysterols	68-78	myeloid differentiation primary response gene 88	Mus musculus	8-13
31239294-7	2019	The quantification of oxysterols, performed by liquid chromatography-(atmospheric pressure chemical ionization (APCI))-mass spectrometry, showed that levels of 7-KC were significantly higher while those of 7alpha-hydroxycholesterol (HC), 24-HC and 27-HC were lower in AAA patients compared with healthy donors.	Oxysterols	22-32	AAA1	Homo sapiens	268-271
31379749-4	2019	Oxysterol concentrations, the expression of key regulators liver X receptors (LXR), farnesoid X receptor (FXR), and oxysterol-binding proteins (OSBP) family are modulated in tumors and plasma of cancer patients, exposing these proteins and selected oxysterols as new potential biomarkers and drug targets.	Oxysterols	0-9	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	65-75
31379749-4	2019	Oxysterol concentrations, the expression of key regulators liver X receptors (LXR), farnesoid X receptor (FXR), and oxysterol-binding proteins (OSBP) family are modulated in tumors and plasma of cancer patients, exposing these proteins and selected oxysterols as new potential biomarkers and drug targets.	Oxysterols	0-9	nuclear receptor subfamily 1 group H member 4	Homo sapiens	106-109
31379749-4	2019	Oxysterol concentrations, the expression of key regulators liver X receptors (LXR), farnesoid X receptor (FXR), and oxysterol-binding proteins (OSBP) family are modulated in tumors and plasma of cancer patients, exposing these proteins and selected oxysterols as new potential biomarkers and drug targets.	Oxysterols	249-259	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	65-75
31379749-5	2019	Evidence about how cholesterol/oxysterol pathways are intertwined with circadian clock is building.	Oxysterols	31-40	clock circadian regulator	Homo sapiens	81-86
31039009-8	2019	Moreover, we found that bile acid and oxysterol metabolism were deeply affected by the absence of hepatic MyD88.	Oxysterols	38-47	myeloid differentiation primary response gene 88	Mus musculus	106-111
31039009-10	2019	Finally, the predisposition to inflammation sensitivity displayed by Myd88DeltaHep mice may be caused by the accumulation of 25-hydroxycholesterol, an oxysterol linked to inflammatory response and metabolic disorders.	Oxysterols	151-160	myeloid differentiation primary response gene 88	Mus musculus	69-82
30910555-5	2019	Relatively high concentrations of this oxysterol markedly increased the release of pro-inflammatory interleukins 6 and 8, monocyte chemoattractant protein-1, vascular endothelial growth factor, as well as matrix metalloproteinases 2 and 9.	Oxysterols	39-48	C-C motif chemokine ligand 2	Homo sapiens	122-156
31085627-3	2019	Oxysterols [24-hydroxycholesterol (24HC), 25-hydroxycholesterol (25HC), 27-hydroxycholesterol (27HC), 7alpha-hydroxycholesterol (7alphaHC), and 7-ketocholesterol (7KC)] were measured at baseline and 5 years using a novel mass spectrometric method, and apolipoproteins were measured using immunoturbidometric diagnostic kits.	Oxysterols	0-10	apolipoprotein E	Homo sapiens	252-267
31085627-6	2019	In MS patients, ApoC-II (all P <= 0.01) and ApoE (all P <= 0.01) changes were positively associated with all oxysterol levels.	Oxysterols	109-118	apolipoprotein C2	Homo sapiens	16-23
31085627-6	2019	In MS patients, ApoC-II (all P <= 0.01) and ApoE (all P <= 0.01) changes were positively associated with all oxysterol levels.	Oxysterols	109-118	apolipoprotein E	Homo sapiens	44-48
31168089-0	2019	Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.	Oxysterols	21-30	smoothened, frizzled class receptor	Homo sapiens	43-53
31137846-5	2019	In this study, we report on the biological and pharmacological evaluation of Oxy186, a semisynthetic oxysterol analogue, as a novel inhibitor of Hh signaling acting downstream of Smo, with encouraging drug-like properties.	Oxysterols	101-110	smoothened, frizzled class receptor	Homo sapiens	179-182
30910555-5	2019	Relatively high concentrations of this oxysterol markedly increased the release of pro-inflammatory interleukins 6 and 8, monocyte chemoattractant protein-1, vascular endothelial growth factor, as well as matrix metalloproteinases 2 and 9.	Oxysterols	39-48	vascular endothelial growth factor A	Homo sapiens	158-192
30471425-8	2019	This can explain the formation of (25R)26,7alpha- and (25S)26,7alpha-dihydroxy epimers of oxysterols and cholestenoic acids; the acid with the former stereochemistry is a liver X receptor (LXR) ligand that increases the number of oculomotor neurons in primary brain cultures.	Oxysterols	90-100	nuclear receptor subfamily 1, group H, member 3	Mus musculus	171-187
30710743-0	2019	Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols.	Oxysterols	14-23	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	64-70
30710743-0	2019	Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols.	Oxysterols	99-109	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	64-70
30660701-4	2019	Here, we review recent developments in oxysterol research, highlighting the biological functions that oxysterols exert through their target nuclear receptors: the liver X receptors, estrogen receptors, RAR-related orphan receptors and the glucocorticoid receptor.	Oxysterols	39-48	nuclear receptor subfamily 3 group C member 1	Homo sapiens	239-262
30710743-6	2019	StarD1 overexpression led to an unanticipated marked down-regulation of oxysterol 7alpha-hydroxylase (Cyp7b1), a marked increase in 26HC, and the formation of a third vital regulatory oxysterol, 24(S)-hydroxycholesterol (24HC), in B6/129 mice livers.	Oxysterols	72-81	steroidogenic acute regulatory protein	Mus musculus	0-6
30710743-9	2019	Just as importantly, it provides evidence for CYP7B1 as a key regulator of three vital intracellular regulatory oxysterol levels.	Oxysterols	112-121	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	46-52
30478861-7	2019	We discovered that oxysterol sensing through the G protein-coupled receptor 183 (GPR183) directs the migration of innate lymphoid cells, which is essential for the formation of lymphoid tissue in the colon.	Oxysterols	19-28	G protein-coupled receptor 183	Homo sapiens	49-79
30478861-7	2019	We discovered that oxysterol sensing through the G protein-coupled receptor 183 (GPR183) directs the migration of innate lymphoid cells, which is essential for the formation of lymphoid tissue in the colon.	Oxysterols	19-28	G protein-coupled receptor 183	Homo sapiens	81-87
30471425-8	2019	This can explain the formation of (25R)26,7alpha- and (25S)26,7alpha-dihydroxy epimers of oxysterols and cholestenoic acids; the acid with the former stereochemistry is a liver X receptor (LXR) ligand that increases the number of oculomotor neurons in primary brain cultures.	Oxysterols	90-100	nuclear receptor subfamily 1, group H, member 3	Mus musculus	189-192
29704538-0	2018	In vitro oxidized HDL and HDL from type 2 diabetes patients have reduced ability to efflux oxysterols from THP-1 macrophages.	Oxysterols	91-101	GLI family zinc finger 2	Homo sapiens	107-112
30459596-0	2018	Heme Oxygenase-1 and Brain Oxysterols Metabolism Are Linked to Egr-1 Expression in Aged Mice Cortex, but Not in Hippocampus.	Oxysterols	27-37	early growth response 1	Mus musculus	63-68
30459596-5	2018	Several in vitro and in vivo studies reported that HO-1 could regulate the metabolism of oxysterols, oxidation products of cholesterol that include markers of oxidative stress.	Oxysterols	89-99	heme oxygenase 1	Mus musculus	51-55
30459596-7	2018	In view of these data, we wanted to investigate whether Egr-1 can be implicated also in the oxysterol metabolism during brain aging.	Oxysterols	92-101	early growth response 1	Mus musculus	56-61
30459596-11	2018	These results are further strenghtened by our observations made with Egr-1 KO mice, confirming our hypothesis concerning the influence of Egr-1 on oxysterol production and accumulation via regulation of the expression of HO-1 in the cortex, but not the hippocampus, of old mice.	Oxysterols	147-156	early growth response 1	Mus musculus	138-143
30459596-11	2018	These results are further strenghtened by our observations made with Egr-1 KO mice, confirming our hypothesis concerning the influence of Egr-1 on oxysterol production and accumulation via regulation of the expression of HO-1 in the cortex, but not the hippocampus, of old mice.	Oxysterols	147-156	heme oxygenase 1	Mus musculus	221-225
29654865-5	2018	Studies performed in cancer cells showed that CT was additionally metabolized into an oxysterol identified as the 6-oxo-cholestan-3beta,5alpha-diol (OCDO), by the 11beta-hydroxysteroid dehydrogenase of type 2 (HSD2), the enzyme which inactivates cortisol into cortisone.	Oxysterols	86-95	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	210-214
30197642-5	2018	Silencing ALOX15B reduced cellular cholesterol and the cholesterol intermediates desmosterol, lanosterol, 24,25-dihydrolanosterol, and lathosterol as well as oxysterols in IL-4-stimulated macrophages.	Oxysterols	158-168	arachidonate 15-lipoxygenase type B	Homo sapiens	10-17
29536114-2	2018	The original classification of the family based on oxysterol-binding activity belies the complex dual lipid-binding specificity of the conserved OSBP homology domain (OHD).	Oxysterols	51-60	oxysterol binding protein	Homo sapiens	145-149
30197642-5	2018	Silencing ALOX15B reduced cellular cholesterol and the cholesterol intermediates desmosterol, lanosterol, 24,25-dihydrolanosterol, and lathosterol as well as oxysterols in IL-4-stimulated macrophages.	Oxysterols	158-168	interleukin 4	Homo sapiens	172-176
29793168-5	2018	Oxysterols treatment significantly altered differentiated Caco-2 cells redox status, leading to oxidant species production and a decrease of GSH levels, after 1 h exposure, followed by an increase of cytokines production, IL-6 and IL-8, after 24 h. Oxysterol cell treatment also induced after 48 h an increase of NO release, due to the induction of iNOS.	Oxysterols	0-10	interleukin 6	Homo sapiens	222-226
29793168-5	2018	Oxysterols treatment significantly altered differentiated Caco-2 cells redox status, leading to oxidant species production and a decrease of GSH levels, after 1 h exposure, followed by an increase of cytokines production, IL-6 and IL-8, after 24 h. Oxysterol cell treatment also induced after 48 h an increase of NO release, due to the induction of iNOS.	Oxysterols	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
29793168-5	2018	Oxysterols treatment significantly altered differentiated Caco-2 cells redox status, leading to oxidant species production and a decrease of GSH levels, after 1 h exposure, followed by an increase of cytokines production, IL-6 and IL-8, after 24 h. Oxysterol cell treatment also induced after 48 h an increase of NO release, due to the induction of iNOS.	Oxysterols	0-9	interleukin 6	Homo sapiens	222-226
29793168-5	2018	Oxysterols treatment significantly altered differentiated Caco-2 cells redox status, leading to oxidant species production and a decrease of GSH levels, after 1 h exposure, followed by an increase of cytokines production, IL-6 and IL-8, after 24 h. Oxysterol cell treatment also induced after 48 h an increase of NO release, due to the induction of iNOS.	Oxysterols	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
29352199-2	2018	Formation and abnormal accumulation of 7DHC and 7DHC-derived oxysterols occur in SLOS patients and in rats treated with the DHCR7 inhibitor AY9944.	Oxysterols	61-71	7-dehydrocholesterol reductase	Rattus norvegicus	124-129
29298812-1	2018	Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-HC), an oxysterol that can play an important role in different biological processes.	Oxysterols	97-106	cholesterol 25-hydroxylase	Homo sapiens	0-26
29298812-1	2018	Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-HC), an oxysterol that can play an important role in different biological processes.	Oxysterols	97-106	cholesterol 25-hydroxylase	Homo sapiens	28-33
29331507-14	2018	Sensing of fatty acids, cholesterol and oxysterols by the RORalpha/gamma ligand-binding domain suggests a plausible functional link between adropin expression and cellular lipid metabolism.	Oxysterols	40-50	energy homeostasis associated	Homo sapiens	140-147
29343433-0	2018	Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.	Oxysterols	0-9	G protein-coupled receptor 183	Mus musculus	39-45
29343433-6	2018	Localized oxysterol production by fibroblastic stromal cells provided an essential signal for colonic lymphoid tissue development, and inflammation-induced increased oxysterol production caused colitis through GPR183-mediated cell recruitment.	Oxysterols	166-175	G protein-coupled receptor 183	Mus musculus	210-216
29343433-7	2018	Our findings show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.	Oxysterols	84-93	G protein-coupled receptor 183	Mus musculus	23-29
29523207-5	2018	Using the BV2 microglial cell line, we explored the effect of lipopolysaccharide (LPS)-induced (M1-type) and IL-4-induced (M2-type) cell activation on oxysterol levels.	Oxysterols	151-160	interleukin 4	Mus musculus	109-113
29343433-7	2018	Our findings show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.	Oxysterols	84-93	G protein-coupled receptor 183	Mus musculus	94-100
27401614-2	2018	OBJECTIVES: In this study, we analyzed the prognostic value of the liver X receptor-alpha (LXR-alpha), a nuclear receptor of a family of cholesterol derivatives called oxysterols, in patients with radically resected NSCLC.	Oxysterols	168-178	nuclear receptor subfamily 1 group H member 3	Homo sapiens	91-100
29126212-4	2017	CYP7B1 deficiency has been shown to lead to accumulation of neurotoxic oxysterols.	Oxysterols	71-81	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
29177442-13	2018	Pharmacologic inhibition of steroidogenesis by aminoglutethimide significantly induced LXR and inhibited SREBP2 target gene mRNA expression, indicating that increased oxysterol production occurs when steroidogenesis is suppressed.	Oxysterols	167-176	sterol regulatory element binding transcription factor 2	Homo sapiens	105-111
29236764-2	2017	We investigated the possibility that dexamethasone could affect activation of monocytic cells induced by oxygenated derivatives of cholesterol (oxysterols) using THP-1 monocyte/macrophage cells.	Oxysterols	144-154	GLI family zinc finger 2	Homo sapiens	162-167
29102636-8	2017	Cell monolayer pre-treatment with the selective inhibitor of MMPs ARP100 or polyphenol (-)-epicathechin, previously shown to inhibit NADPH oxidase in the same model system, demonstrated that the decrease of the three tight junction proteins was mainly a consequence of MMPs induction, which was in turn dependent on the pro-oxidant property of the oxysterols investigated.	Oxysterols	348-358	matrix metallopeptidase 2	Homo sapiens	61-65
28928671-16	2017	In addition, the increase and reduction of Cyp27a1 and Cyp7b1 in trained mice may contribute to enhance levels of 27-OH C. Both oxysterols may act as an alternative pathway for the RCT contributing to the reduction of cholesterol in the aortic arch preventing atherogenesis.	Oxysterols	128-138	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	43-50
28807695-0	2017	Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters.	Oxysterols	21-30	nuclear receptor subfamily 1, group H, member 3	Mus musculus	53-56
28807695-11	2017	Taken together, our data demonstrate enhanced cholesterol and oxysterol levels by doxorubicin, resulting in a LXR-dependent upregulation of abca1 and abcg1.	Oxysterols	62-71	nuclear receptor subfamily 1, group H, member 3	Mus musculus	110-113
28807695-11	2017	Taken together, our data demonstrate enhanced cholesterol and oxysterol levels by doxorubicin, resulting in a LXR-dependent upregulation of abca1 and abcg1.	Oxysterols	62-71	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	140-145
28807695-11	2017	Taken together, our data demonstrate enhanced cholesterol and oxysterol levels by doxorubicin, resulting in a LXR-dependent upregulation of abca1 and abcg1.	Oxysterols	62-71	ATP binding cassette subfamily G member 1	Mus musculus	150-155
28993775-0	2017	IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production.	Oxysterols	48-58	interleukin 27	Homo sapiens	0-5
28993775-0	2017	IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production.	Oxysterols	48-58	interleukin 10	Homo sapiens	74-79
28993775-7	2017	Here, we assessed oxysterol levels in subset of CD4+ T cells and demonstrated that 25-OHC and transcript levels of its synthesizing enzyme, cholesterol 25-hydroxylase, were specifically increased in IL-27-induced type 1 regulatory T (TR1) cells.	Oxysterols	18-27	cholesterol 25-hydroxylase	Homo sapiens	140-166
28993775-7	2017	Here, we assessed oxysterol levels in subset of CD4+ T cells and demonstrated that 25-OHC and transcript levels of its synthesizing enzyme, cholesterol 25-hydroxylase, were specifically increased in IL-27-induced type 1 regulatory T (TR1) cells.	Oxysterols	18-27	interleukin 27	Homo sapiens	199-204
28993775-9	2017	Not only do these findings unravel molecular mechanisms accounting for IL-27 signaling but also they highlight oxysterols as pro-inflammatory mediators that dampens regulatory T cell responses and thus unleash a pro-inflammatory response.	Oxysterols	111-121	interleukin 27	Homo sapiens	71-76
28815947-0	2017	Olive Oil Phenolics Prevent Oxysterol-Induced Proinflammatory Cytokine Secretion and Reactive Oxygen Species Production in Human Peripheral Blood Mononuclear Cells, Through Modulation of p38 and JNK Pathways.	Oxysterols	28-37	mitogen-activated protein kinase 14	Homo sapiens	187-190
28815947-0	2017	Olive Oil Phenolics Prevent Oxysterol-Induced Proinflammatory Cytokine Secretion and Reactive Oxygen Species Production in Human Peripheral Blood Mononuclear Cells, Through Modulation of p38 and JNK Pathways.	Oxysterols	28-37	mitogen-activated protein kinase 8	Homo sapiens	195-198
29033131-0	2017	Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.	Oxysterols	0-9	absent in melanoma 2	Homo sapiens	54-58
28888956-0	2017	Oxysterol, 5alpha-cholestan-3-one, modulates a contractile response to beta2-adrenoceptor stimulation in the mouse atria: Involvement of NO signaling.	Oxysterols	0-9	adrenergic receptor, beta 2	Mus musculus	71-89
28928671-16	2017	In addition, the increase and reduction of Cyp27a1 and Cyp7b1 in trained mice may contribute to enhance levels of 27-OH C. Both oxysterols may act as an alternative pathway for the RCT contributing to the reduction of cholesterol in the aortic arch preventing atherogenesis.	Oxysterols	128-138	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	55-61
28125291-4	2017	OBJECTIVES: To determine whether oxysterol ligands for EBI2 are increased in asthma exacerbation, and if or how they promote Eos pulmonary migration.	Oxysterols	33-42	G protein-coupled receptor 183	Homo sapiens	55-59
28869506-2	2017	It is now well established that ABCG1 promotes the export of lipids, including cholesterol, phospholipids, sphingomyelin and oxysterols, and plays a key role in the maintenance of tissue lipid homeostasis.	Oxysterols	125-135	ATP binding cassette subfamily G member 1	Homo sapiens	32-37
29029490-3	2017	When cells were exposed to oxysterols in fetal bovine serum-supplemented medium, 7-ketocholesterol (7-KC), but not 27-hydroxycholesterol (27-HC), decreased the cytotoxicity of doxorubicin in MCF-7 (high estrogen receptor (ER)alpha/ERbeta ratio) cells and the decreased cytotoxicity was restored by the P-glycoprotein inhibitor verapamil.	Oxysterols	27-37	estrogen receptor 2	Homo sapiens	231-237
28576574-9	2017	In summary, the present study revealed a novel mechanism of human LPL gene induction by oxysterols in the liver with is based on physical and functional interactions between transcription factors LXRalpha and FOXA2.	Oxysterols	88-98	lipoprotein lipase	Homo sapiens	66-69
28576574-9	2017	In summary, the present study revealed a novel mechanism of human LPL gene induction by oxysterols in the liver with is based on physical and functional interactions between transcription factors LXRalpha and FOXA2.	Oxysterols	88-98	nuclear receptor subfamily 1 group H member 3	Homo sapiens	196-204
28576574-9	2017	In summary, the present study revealed a novel mechanism of human LPL gene induction by oxysterols in the liver with is based on physical and functional interactions between transcription factors LXRalpha and FOXA2.	Oxysterols	88-98	forkhead box A2	Homo sapiens	209-214
28442559-2	2017	27HC is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis.	Oxysterols	11-20	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	68-75
29130021-3	2017	Oxygenated cholesterol derivative oxysterols are known to be endogenous ligands of the liver X receptor (LXR), a nuclear receptor with anti-cholestasis activity, whereas the sulfated oxysterols antagonize LXR signaling.	Oxysterols	34-44	nuclear receptor subfamily 1, group H, member 3	Mus musculus	87-103
29130021-3	2017	Oxygenated cholesterol derivative oxysterols are known to be endogenous ligands of the liver X receptor (LXR), a nuclear receptor with anti-cholestasis activity, whereas the sulfated oxysterols antagonize LXR signaling.	Oxysterols	34-44	nuclear receptor subfamily 1, group H, member 3	Mus musculus	105-108
29130021-3	2017	Oxygenated cholesterol derivative oxysterols are known to be endogenous ligands of the liver X receptor (LXR), a nuclear receptor with anti-cholestasis activity, whereas the sulfated oxysterols antagonize LXR signaling.	Oxysterols	34-44	nuclear receptor subfamily 1, group H, member 3	Mus musculus	205-208
29130021-3	2017	Oxygenated cholesterol derivative oxysterols are known to be endogenous ligands of the liver X receptor (LXR), a nuclear receptor with anti-cholestasis activity, whereas the sulfated oxysterols antagonize LXR signaling.	Oxysterols	183-193	nuclear receptor subfamily 1, group H, member 3	Mus musculus	205-208
29130021-8	2017	The protective effect of the STS transgene was associated with the activation of LXR and induction of LXR target genes, likely because of the increased conversion of the antagonistic oxysterol sulfates to the agonistic oxysterols.	Oxysterols	219-229	nuclear receptor subfamily 1, group H, member 3	Mus musculus	102-105
27589058-6	2017	TC, LDL-C, and ApoB were associated with higher levels of all oxysterols (all p &lt; 0.05) in HC.	Oxysterols	62-72	apolipoprotein B	Homo sapiens	15-19
28356389-5	2017	Mechanistically, c-Fos decreases expression and activity of the nuclear receptor LXRalpha, leading to increased hepatic cholesterol and accumulation of toxic oxysterols and bile acids.	Oxysterols	158-168	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
28356389-5	2017	Mechanistically, c-Fos decreases expression and activity of the nuclear receptor LXRalpha, leading to increased hepatic cholesterol and accumulation of toxic oxysterols and bile acids.	Oxysterols	158-168	nuclear receptor subfamily 1 group H member 3	Homo sapiens	81-89
28738017-8	2017	Last, we provide evidence that oxysterol metabolism by Batf3-dependent DCs is important for EBI2-dependent positioning of activated DCIR2+ DCs.	Oxysterols	31-40	basic leucine zipper ATF-like transcription factor 3	Homo sapiens	55-60
28738017-8	2017	Last, we provide evidence that oxysterol metabolism by Batf3-dependent DCs is important for EBI2-dependent positioning of activated DCIR2+ DCs.	Oxysterols	31-40	G protein-coupled receptor 183	Homo sapiens	92-96
28011707-2	2017	LXRalpha binds to and is regulated by synthetic (T-0901317, GW3695) and endogenous (oxysterols) ligands.	Oxysterols	84-94	nuclear receptor subfamily 1 group H member 3	Homo sapiens	0-8
27490478-9	2017	Furthermore, the present study adds a new facet to the spectrum of Hh pathway modulation that naturally occurring oxysterol derivatives are capable of, ranging from allosteric activation of the pathway via Smo binding to inhibition of the pathway downstream of Smo.	Oxysterols	114-123	smoothened, frizzled class receptor	Homo sapiens	206-209
27490478-9	2017	Furthermore, the present study adds a new facet to the spectrum of Hh pathway modulation that naturally occurring oxysterol derivatives are capable of, ranging from allosteric activation of the pathway via Smo binding to inhibition of the pathway downstream of Smo.	Oxysterols	114-123	smoothened, frizzled class receptor	Homo sapiens	261-264
27687218-5	2016	The oxysterols potentially most closely involved in the pathogenesis of AD are 24-hydroxycholesterol and 27-hydroxycholesterol, respectively deriving from cholesterol oxidation by the enzymes CYP46A1 and CYP27A1.	Oxysterols	4-14	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	192-199
28052250-1	2017	The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab.	Oxysterols	24-34	G protein-coupled receptor 183	Homo sapiens	105-109
27729467-7	2016	Excessive stimulation with the oxysterol 25-hydroxycholesterol disassembles the ORP4L/Galphaq/11/PLCbeta3 complexes, resulting in reduced PLCbeta3 activity, IP3 production, and Ca2+ release, as well as decreased Bcl-XL expression and increased apoptosis.	Oxysterols	31-40	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	86-93
27729467-7	2016	Excessive stimulation with the oxysterol 25-hydroxycholesterol disassembles the ORP4L/Galphaq/11/PLCbeta3 complexes, resulting in reduced PLCbeta3 activity, IP3 production, and Ca2+ release, as well as decreased Bcl-XL expression and increased apoptosis.	Oxysterols	31-40	phospholipase C, beta 3	Mus musculus	97-105
27729467-7	2016	Excessive stimulation with the oxysterol 25-hydroxycholesterol disassembles the ORP4L/Galphaq/11/PLCbeta3 complexes, resulting in reduced PLCbeta3 activity, IP3 production, and Ca2+ release, as well as decreased Bcl-XL expression and increased apoptosis.	Oxysterols	31-40	phospholipase C, beta 3	Mus musculus	138-146
27729467-7	2016	Excessive stimulation with the oxysterol 25-hydroxycholesterol disassembles the ORP4L/Galphaq/11/PLCbeta3 complexes, resulting in reduced PLCbeta3 activity, IP3 production, and Ca2+ release, as well as decreased Bcl-XL expression and increased apoptosis.	Oxysterols	31-40	BCL2-like 1	Mus musculus	212-218
27052460-0	2017	Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury.	Oxysterols	108-117	nuclear receptor subfamily 1, group H, member 3	Mus musculus	126-129
27052460-10	2017	The above oxysterols are physiological ligands of liver X receptors (LXRs), and SULT2B1b suppressed oxysterol-induced LXR activation.	Oxysterols	10-20	nuclear receptor subfamily 1, group H, member 3	Mus musculus	69-72
27052460-10	2017	The above oxysterols are physiological ligands of liver X receptors (LXRs), and SULT2B1b suppressed oxysterol-induced LXR activation.	Oxysterols	10-19	nuclear receptor subfamily 1, group H, member 3	Mus musculus	69-72
27052460-12	2017	Our data indicate that upregulation of SULT2B1b might promote HOC proliferation and aggravate liver injury via the suppression of oxysterol-induced LXR activation in chemically induced mouse liver injury.	Oxysterols	130-139	nuclear receptor subfamily 1, group H, member 3	Mus musculus	148-151
27687218-5	2016	The oxysterols potentially most closely involved in the pathogenesis of AD are 24-hydroxycholesterol and 27-hydroxycholesterol, respectively deriving from cholesterol oxidation by the enzymes CYP46A1 and CYP27A1.	Oxysterols	4-14	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	204-211
27658369-0	2016	Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability.	Oxysterols	28-39	G protein-coupled receptor 183	Homo sapiens	57-61
27688150-6	2016	These data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity through decreasing the excess intracellular cholesterols/sterols (especially various oxysterols), which is essential for the action of the human leukocytes.	Oxysterols	356-366	sterol O-acyltransferase 2	Homo sapiens	32-37
26971834-1	2016	Recent data and publications suggest a promiscuous behaviour for GPR17, a class-A GPCR operated by different classes of ligands, such as uracil nucleotides, cysteinyl-leukotrienes and oxysterols.	Oxysterols	184-194	G protein-coupled receptor 17	Homo sapiens	65-70
27653972-1	2016	In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.	Oxysterols	73-82	cytochrome P450, family 46, subfamily a, polypeptide 1	Rattus norvegicus	115-141
27653972-1	2016	In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.	Oxysterols	73-82	cytochrome P450, family 46, subfamily a, polypeptide 1	Rattus norvegicus	143-150
27653972-1	2016	In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.	Oxysterols	73-82	cytochrome P450, family 46, subfamily a, polypeptide 1	Rattus norvegicus	167-174
27079462-8	2016	Finally, CysC treatment minimized oxysterol-mediated cellular lipid accumulation.	Oxysterols	34-43	cystatin C	Mus musculus	9-13
26370385-10	2016	Reduced cytochrome P450-7B1 enzymatic activity could alter the balance among neurotoxic and neuroprotective oxysterols promoting motor neuron degeneration and/or immune response.	Oxysterols	108-118	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-27
27109381-7	2016	We showed that oxysterol toxicity is mediated by P2X7 receptor activation.	Oxysterols	15-24	purinergic receptor P2X 7	Homo sapiens	49-62
27109381-9	2016	Taken together our data suggest a pivotal role of P2X7 receptor-pannexin-1 in oxysterols toxicity in retinal cells which could be an important target to develop new treatments for AMD.	Oxysterols	78-88	purinergic receptor P2X 7	Homo sapiens	50-63
27109381-9	2016	Taken together our data suggest a pivotal role of P2X7 receptor-pannexin-1 in oxysterols toxicity in retinal cells which could be an important target to develop new treatments for AMD.	Oxysterols	78-88	pannexin 1	Homo sapiens	64-74
26971834-1	2016	Recent data and publications suggest a promiscuous behaviour for GPR17, a class-A GPCR operated by different classes of ligands, such as uracil nucleotides, cysteinyl-leukotrienes and oxysterols.	Oxysterols	184-194	G protein-coupled receptor 166 pseudogene	Homo sapiens	82-86
26733147-7	2016	Interestingly, in NP-C alone, we observed that plasma oxysterols correlate negatively with patient"s age and positively with serum total bilirubin, suggesting the potential relationship between oxysterol levels and hepatic disease status.	Oxysterols	54-63	NPC intracellular cholesterol transporter 1	Homo sapiens	18-22
26992564-0	2016	Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis.	Oxysterols	0-9	oxysterol binding protein like 2	Homo sapiens	53-57
26893256-6	2016	Immunoblotting showed that the oxysterol activated the ER transmembrane resident kinases of IRE1alpha, PERK and ATF4 and triggered caspase-12 signaling cascades, which was reversed by alpha-asarone.	Oxysterols	31-40	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	92-101
26893256-6	2016	Immunoblotting showed that the oxysterol activated the ER transmembrane resident kinases of IRE1alpha, PERK and ATF4 and triggered caspase-12 signaling cascades, which was reversed by alpha-asarone.	Oxysterols	31-40	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	103-107
26893256-6	2016	Immunoblotting showed that the oxysterol activated the ER transmembrane resident kinases of IRE1alpha, PERK and ATF4 and triggered caspase-12 signaling cascades, which was reversed by alpha-asarone.	Oxysterols	31-40	activating transcription factor 4	Mus musculus	112-116
26893256-6	2016	Immunoblotting showed that the oxysterol activated the ER transmembrane resident kinases of IRE1alpha, PERK and ATF4 and triggered caspase-12 signaling cascades, which was reversed by alpha-asarone.	Oxysterols	31-40	caspase 12	Mus musculus	131-141
26893256-9	2016	Finally, alpha-asarone disturbed oxysterol-elicited signaling of PERK and ATF4 responsible for CHOP induction.	Oxysterols	33-42	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	65-69
26893256-9	2016	Finally, alpha-asarone disturbed oxysterol-elicited signaling of PERK and ATF4 responsible for CHOP induction.	Oxysterols	33-42	activating transcription factor 4	Mus musculus	74-78
26893256-9	2016	Finally, alpha-asarone disturbed oxysterol-elicited signaling of PERK and ATF4 responsible for CHOP induction.	Oxysterols	33-42	DNA-damage inducible transcript 3	Mus musculus	95-99
27147587-4	2016	The bile acids most elevated in the NPC subjects were identified as 3beta,5alpha,6beta-trihydroxycholanic acid and its glycine conjugate, which were shown to be metabolites of cholestane-3beta,5alpha,6beta-triol, an oxysterol elevated in NPC.	Oxysterols	216-225	NPC intracellular cholesterol transporter 1	Homo sapiens	36-39
26689473-4	2016	It remains to identify the link between ERK/Akt up-regulation and the consequent quenching effect on ROS intracellular level that efficiently and markedly delay the pro-apoptotic effect of the oxysterol.	Oxysterols	193-202	mitogen-activated protein kinase 1	Homo sapiens	40-43
26689473-4	2016	It remains to identify the link between ERK/Akt up-regulation and the consequent quenching effect on ROS intracellular level that efficiently and markedly delay the pro-apoptotic effect of the oxysterol.	Oxysterols	193-202	AKT serine/threonine kinase 1	Homo sapiens	44-47
26689473-6	2016	The 27-OH-exerted induction of Nrf2 and subsequently of the target genes, HO-1 and NQO-1, was proved to be: (i) dependent upon the activation of ERK and Akt pathways, (ii) directly responsible for the quenching of intracellular oxidative stress and by this way (iii) ultimately responsible for the observed oxysterol-induced pro-survival response.	Oxysterols	307-316	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
26689473-6	2016	The 27-OH-exerted induction of Nrf2 and subsequently of the target genes, HO-1 and NQO-1, was proved to be: (i) dependent upon the activation of ERK and Akt pathways, (ii) directly responsible for the quenching of intracellular oxidative stress and by this way (iii) ultimately responsible for the observed oxysterol-induced pro-survival response.	Oxysterols	307-316	heme oxygenase 1	Homo sapiens	74-78
26689473-6	2016	The 27-OH-exerted induction of Nrf2 and subsequently of the target genes, HO-1 and NQO-1, was proved to be: (i) dependent upon the activation of ERK and Akt pathways, (ii) directly responsible for the quenching of intracellular oxidative stress and by this way (iii) ultimately responsible for the observed oxysterol-induced pro-survival response.	Oxysterols	307-316	NAD(P)H quinone dehydrogenase 1	Homo sapiens	83-88
26689473-6	2016	The 27-OH-exerted induction of Nrf2 and subsequently of the target genes, HO-1 and NQO-1, was proved to be: (i) dependent upon the activation of ERK and Akt pathways, (ii) directly responsible for the quenching of intracellular oxidative stress and by this way (iii) ultimately responsible for the observed oxysterol-induced pro-survival response.	Oxysterols	307-316	mitogen-activated protein kinase 1	Homo sapiens	145-148
26689473-6	2016	The 27-OH-exerted induction of Nrf2 and subsequently of the target genes, HO-1 and NQO-1, was proved to be: (i) dependent upon the activation of ERK and Akt pathways, (ii) directly responsible for the quenching of intracellular oxidative stress and by this way (iii) ultimately responsible for the observed oxysterol-induced pro-survival response.	Oxysterols	307-316	AKT serine/threonine kinase 1	Homo sapiens	153-156
26082378-1	2015	Cytochrome P450 CYP27A1 is the only enzyme in humans converting cholesterol to 27-hydroxycholesterol, an oxysterol of multiple functions, including tissue-specific modulation of estrogen and liver X receptors.	Oxysterols	105-114	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	16-23
26898310-4	2016	We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system.	Oxysterols	45-54	cholesterol 25-hydroxylase	Homo sapiens	81-86
26898310-4	2016	We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system.	Oxysterols	45-54	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	91-97
27033215-3	2016	Indeed, oxysterols inhibit the expression of the chemokine receptor CCR7 on dendritic cells (DC) in an LXR-dependent manner, thus impairing DC migration to secondary lymphoid organs, and therefore dampening the induction of successful antitumor responses.We have resorted to direct (i.e., luciferase-based LXR activation assay) and indirect (i.e., activation of LXR target genes in dendritic cells) methods in order to assess the presence of LXR ligands (oxysterols) in tumor-conditioned media.These two methods are also suitable to study strategies to block oxysterol release by tumor cells.	Oxysterols	8-17	C-C motif chemokine receptor 7	Homo sapiens	68-72
26232622-4	2015	In this regard, oxysterols are particular in causing alpha-synuclein aggregation and destruction of dopamine containing neurons in in vitro models, which is linked to their direct influence on oxidative stress provoking potency.	Oxysterols	16-26	synuclein alpha	Homo sapiens	53-68
25998247-1	2015	Lysophosphatidylcholine (LPC) and oxysterols which are major components in oxidized low-density lipoprotein have been shown to possess an opposite effect on the expression of sterol regulatory element-binding protein-2 (SREBP-2) target genes in endothelial cells.	Oxysterols	34-44	sterol regulatory element binding transcription factor 2	Homo sapiens	175-218
25998247-1	2015	Lysophosphatidylcholine (LPC) and oxysterols which are major components in oxidized low-density lipoprotein have been shown to possess an opposite effect on the expression of sterol regulatory element-binding protein-2 (SREBP-2) target genes in endothelial cells.	Oxysterols	34-44	sterol regulatory element binding transcription factor 2	Homo sapiens	220-227
26812621-4	2016	We have previously shown that BMMs from sg/sg mice have significantly decreased expression of cholesterol 25-hydroxylase (Ch25h) mRNA, the enzyme that produces the oxysterol, 25-hydroxycholesterol (25HC), and now confirm this at the protein level.	Oxysterols	164-173	cholesterol 25-hydroxylase	Mus musculus	94-120
26812621-4	2016	We have previously shown that BMMs from sg/sg mice have significantly decreased expression of cholesterol 25-hydroxylase (Ch25h) mRNA, the enzyme that produces the oxysterol, 25-hydroxycholesterol (25HC), and now confirm this at the protein level.	Oxysterols	164-173	cholesterol 25-hydroxylase	Mus musculus	122-127
26577244-5	2015	The promoter region of CH25H was originally hypermethylated in HL-60 and MDS-L cells, but DAC treatment induced their hypomethylation together with increased CH25H mRNA expression, activation of CH25H-oxysterol pathway, 25-OHC production and apoptotic cell death.	Oxysterols	201-210	cholesterol 25-hydroxylase	Homo sapiens	23-28
26577244-9	2015	The present study raises a possibility that DNMT inhibitors activate CH25H-oxysterol pathway by their hypomethylating mechanism and induce leukemic cell death.	Oxysterols	75-84	DNA methyltransferase 1	Homo sapiens	44-48
26577244-9	2015	The present study raises a possibility that DNMT inhibitors activate CH25H-oxysterol pathway by their hypomethylating mechanism and induce leukemic cell death.	Oxysterols	75-84	cholesterol 25-hydroxylase	Homo sapiens	69-74
26239048-3	2015	We aimed to know the sensitivity and specificity of these biomarkers for the diagnosis of NPC compared with other diseases that can potentially lead to oxysterol alterations.	Oxysterols	152-161	NPC intracellular cholesterol transporter 1	Homo sapiens	90-93
26344074-2	2015	We recently reported that 25-hydroxycholesterol, a representative LXR-activating oxysterol, suppresses IL-6 production in mouse mast cells (MCs) following its engagement of the high-affinity IgE receptor (FcepsilonRI).	Oxysterols	81-90	nuclear receptor subfamily 1, group H, member 2	Mus musculus	66-69
26344074-2	2015	We recently reported that 25-hydroxycholesterol, a representative LXR-activating oxysterol, suppresses IL-6 production in mouse mast cells (MCs) following its engagement of the high-affinity IgE receptor (FcepsilonRI).	Oxysterols	81-90	interleukin 6	Mus musculus	103-107
26344074-2	2015	We recently reported that 25-hydroxycholesterol, a representative LXR-activating oxysterol, suppresses IL-6 production in mouse mast cells (MCs) following its engagement of the high-affinity IgE receptor (FcepsilonRI).	Oxysterols	81-90	Fc receptor, IgE, high affinity I, alpha polypeptide	Mus musculus	205-216
25742736-0	2015	THP1 macrophages oxidized cholesterol, generating 7-derivative oxysterols specifically released by HDL.	Oxysterols	63-73	GLI family zinc finger 2	Homo sapiens	0-4
25151952-6	2015	Recent observations from experiments using selective inhibitors and studies with transgenic mice indicated a role for 11beta-HSD1 in oxysterol metabolism and in bile acid homeostasis, with evidence for glucocorticoid-independent effects on gene expression.	Oxysterols	133-142	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	118-129
25218443-11	2015	All sterols that possess the iso-octyl side chain including cholesterol, oxysterols, various plant sterols could all be activators of ACAT.	Oxysterols	73-83	acetyl-CoA acetyltransferase 1	Homo sapiens	134-138
25757594-3	2015	This study aimed to determine the effects on TLR4 activation of two reactive oxidized lipids carried by oxidized low-density lipoproteins, the oxysterol 27-hydroxycholesterol (27-OH) and the aldehyde 4-hydroxynonenal (HNE), both of which accumulate in atherosclerotic plaques and play a key role in the pathogenesis of atherosclerosis.	Oxysterols	143-152	toll like receptor 4	Homo sapiens	45-49
25681634-1	2015	Oxysterol-binding protein (OSBP) and its homologues (ORPs) are lipid-binding/transfer proteins with affinity for oxysterols, cholesterol and glycerophospholipids.	Oxysterols	113-123	oxysterol binding protein	Homo sapiens	0-25
25681634-1	2015	Oxysterol-binding protein (OSBP) and its homologues (ORPs) are lipid-binding/transfer proteins with affinity for oxysterols, cholesterol and glycerophospholipids.	Oxysterols	113-123	oxysterol binding protein	Homo sapiens	27-31
25681634-9	2015	In conclusion, treatment with statin or oxysterol ligands modify the subcellular targeting of ORP-VAPA complexes, consistent with the notion that this machinery controls lipid homeostasis and signaling at organelle interfaces.	Oxysterols	40-49	VAMP associated protein A	Homo sapiens	98-102
25742736-8	2015	Incubation of THP1 macrophages with nLDL or oxLDL, induced a 2- and 100-fold increase in oxysterol production, respectively.	Oxysterols	89-98	GLI family zinc finger 2	Homo sapiens	14-18
25742736-9	2015	Both oxysterols derived from LDL cholesterol and cellular cholesterol were readily exported to HDL whereas apoA1 was inefficient, showing that HDL plays a major role in the removal of excess oxysterols in THP1 macrophages.	Oxysterols	5-15	GLI family zinc finger 2	Homo sapiens	205-209
25630716-0	2015	The oxysterol 27-hydroxycholesterol increases oxidative stress and regulate Nrf2 signaling pathway in astrocyte cells.	Oxysterols	4-13	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
25736858-0	2015	The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics.	Oxysterols	76-86	mitogen-activated protein kinase 14	Homo sapiens	12-15
25736858-4	2015	p38 MAPK activation plays a major role, while other signal branches, i.e. the JNK and ERK pathways, make minor contributions to the intestinal inflammation induced by dietary oxysterols.	Oxysterols	175-185	mitogen-activated protein kinase 8	Homo sapiens	78-81
25736858-4	2015	p38 MAPK activation plays a major role, while other signal branches, i.e. the JNK and ERK pathways, make minor contributions to the intestinal inflammation induced by dietary oxysterols.	Oxysterols	175-185	mitogen-activated protein kinase 1	Homo sapiens	86-89
25736858-11	2015	These findings show a major role of the NOX1/p38 MAPK/NF-kappaB signaling axis in the activation of oxysterol-dependent intestinal inflammation, and confirm the concept that phenolics act as modulators at different sites of pro-oxidant and pro-inflammatory cell signals.	Oxysterols	100-109	NADPH oxidase 1	Homo sapiens	40-44
25736858-11	2015	These findings show a major role of the NOX1/p38 MAPK/NF-kappaB signaling axis in the activation of oxysterol-dependent intestinal inflammation, and confirm the concept that phenolics act as modulators at different sites of pro-oxidant and pro-inflammatory cell signals.	Oxysterols	100-109	mitogen-activated protein kinase 14	Homo sapiens	45-48
26015858-2	2015	Macrophage generation of oxysterol activators of liver X receptors (LXRs), via sterol 27-hydroxylase, is regulated by the rate of flux of cholesterol to the inner mitochondrial membrane, via a complex of cholesterol trafficking proteins.	Oxysterols	25-34	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	79-100
25736222-3	2015	Our study shows that LXR ligands such as oxysterols, GW3965 or TO901317, as well as RXR ligands like 9cis retinoic acid or SR11237, decreased LPS-induced expression of COX-2 and mPGES-1.	Oxysterols	41-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-173
25736222-3	2015	Our study shows that LXR ligands such as oxysterols, GW3965 or TO901317, as well as RXR ligands like 9cis retinoic acid or SR11237, decreased LPS-induced expression of COX-2 and mPGES-1.	Oxysterols	41-51	prostaglandin E synthase	Mus musculus	178-185
26598835-5	2015	Cholesterol metabolites such as oxysterols are involved in regulating sterol metabolism by binding to the nuclear receptor, liver X receptor (LXR).	Oxysterols	32-42	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	130-140
25852561-3	2015	In 2011 we and another group reported the identification of 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol, as the likely physiological ligand of EBI2.	Oxysterols	114-123	G protein-coupled receptor 183	Homo sapiens	163-167
25523141-8	2015	Oxysterol combinations also increased protein levels of mitochondrial respiratory complexes I-V. We also found that SS treatment increased hedgehog signaling target genes, Smo and Gli1 expression.	Oxysterols	0-9	smoothened, frizzled class receptor	Mus musculus	172-175
25523141-8	2015	Oxysterol combinations also increased protein levels of mitochondrial respiratory complexes I-V. We also found that SS treatment increased hedgehog signaling target genes, Smo and Gli1 expression.	Oxysterols	0-9	GLI-Kruppel family member GLI1	Mus musculus	180-184
25523141-10	2015	Subsequently, oxysterol-induced Wnt/beta-catenin pathways were inhibited by repression of Hh signaling and mitochondrial biogenesis.	Oxysterols	14-23	catenin (cadherin associated protein), beta 1	Mus musculus	36-48
25600868-5	2015	Conversely, FMO3 knockdown exacerbates hepatic endoplasmic reticulum (ER) stress and inflammation in part by decreasing hepatic oxysterol levels and subsequent LXR activation.	Oxysterols	128-137	flavin containing monooxygenase 3	Mus musculus	12-16
25618030-13	2015	CONCLUSIONS: CD1d acts as a cell surface receptor that recognizes and binds oxysterols and initializes a pathway connecting oxysterol binding to PPARgamma activation.	Oxysterols	76-86	CD1d molecule	Homo sapiens	13-17
25618030-13	2015	CONCLUSIONS: CD1d acts as a cell surface receptor that recognizes and binds oxysterols and initializes a pathway connecting oxysterol binding to PPARgamma activation.	Oxysterols	76-86	peroxisome proliferator activated receptor gamma	Homo sapiens	145-154
25618030-13	2015	CONCLUSIONS: CD1d acts as a cell surface receptor that recognizes and binds oxysterols and initializes a pathway connecting oxysterol binding to PPARgamma activation.	Oxysterols	76-85	CD1d molecule	Homo sapiens	13-17
25618030-13	2015	CONCLUSIONS: CD1d acts as a cell surface receptor that recognizes and binds oxysterols and initializes a pathway connecting oxysterol binding to PPARgamma activation.	Oxysterols	76-85	peroxisome proliferator activated receptor gamma	Homo sapiens	145-154
25095726-12	2015	CONCLUSION: Whilst acknowledging the limitations of this study, we conclude that screening ID children and adolescents with oxysterol tests compared to current practice for the diagnosis of NP-C is a dominant strategy with clinical and economic benefits.	Oxysterols	124-133	NPC intracellular cholesterol transporter 1	Homo sapiens	190-194
25834900-3	2010	An exciting new development in the field is the revelation of a novel chemotactic axis involving the recognition of oxysterol compounds by the orphan G-protein-coupled receptor (GPCR), Epstein-Barr virus-induced gene 2 (EBI2).	Oxysterols	116-125	G protein-coupled receptor 183	Homo sapiens	220-224
25834900-6	2010	Most recently, two research teams made the unlikely discovery that oxysterol compounds, previously known to bind nuclear receptors, are the physiologic ligands for EBI2.	Oxysterols	67-76	G protein-coupled receptor 183	Homo sapiens	164-168
25165144-4	2014	We show here that in yeast the oxysterol-binding proteins Osh1-Osh7 are collectively needed to maintain the normal distribution of PI4P and that Osh4p is critical in this function.	Oxysterols	31-40	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	58-62
25266234-9	2014	While oxysterol treatment increased caspase 3 activity, cell death was not rescued in its absence.	Oxysterols	6-15	caspase 3	Homo sapiens	36-45
25218961-7	2014	Total oxysterols significantly decreased as HO-1 expression increased in GFAP.HMOX1 mice expressing high levels of HO-1, whereas total oxysterols increased as HO-1 expression increased in aged 3xTg-AD mice.	Oxysterols	6-16	glial fibrillary acidic protein	Mus musculus	73-77
25772320-9	2015	In two of these patients, the positive oxysterol result led to a rapid diagnosis of NPC2 by genetic analysis.	Oxysterols	39-48	NPC intracellular cholesterol transporter 2	Homo sapiens	84-88
25152366-4	2014	Similarly, oxysterols promiscuously operate CXCR2, a chemokine receptor participating to immune reactions and cancer development.	Oxysterols	11-21	C-X-C motif chemokine receptor 2	Homo sapiens	44-49
25110320-3	2014	A net up-regulation of survival signaling, involving the extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt phosphorylation pathways, was observed in U937 promonocytic cells cultivated over time in the presence of a low micromolar concentration of the oxysterol.	Oxysterols	286-295	mitogen-activated protein kinase 1	Homo sapiens	57-94
25110320-5	2014	In turn, stimulation of ERK and PI3K/Akt both significantly quenched ROS steady state and markedly phosphorylated Bad, thereby determining a marked delay of the oxysterol s proapoptotic action.	Oxysterols	161-170	mitogen-activated protein kinase 1	Homo sapiens	24-27
25110320-5	2014	In turn, stimulation of ERK and PI3K/Akt both significantly quenched ROS steady state and markedly phosphorylated Bad, thereby determining a marked delay of the oxysterol s proapoptotic action.	Oxysterols	161-170	AKT serine/threonine kinase 1	Homo sapiens	37-40
25339664-4	2014	Loss of ABCG1 results in increased levels of specific oxysterols, phosphatidylcholines, and oxidized phospholipids, including 1-palmitoyl-2-(5"-oxovaleroyl)-sn-glycero-3-phosphocholine, in the lungs.	Oxysterols	54-64	ATP binding cassette subfamily G member 1	Mus musculus	8-13
25134999-0	2014	Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.	Oxysterols	0-10	sterol regulatory element binding transcription factor 2	Homo sapiens	48-55
25134999-6	2014	siRNA-mediated gene silencing was used to test the involvement of oxysterol-mediated repression of SREBP-2 in STOX synergy.	Oxysterols	66-75	sterol regulatory element binding transcription factor 2	Homo sapiens	99-106
25165144-4	2014	We show here that in yeast the oxysterol-binding proteins Osh1-Osh7 are collectively needed to maintain the normal distribution of PI4P and that Osh4p is critical in this function.	Oxysterols	31-40	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	63-67
25165144-4	2014	We show here that in yeast the oxysterol-binding proteins Osh1-Osh7 are collectively needed to maintain the normal distribution of PI4P and that Osh4p is critical in this function.	Oxysterols	31-40	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	145-150
24891333-8	2014	In addition to reducing the cholesteryl ester content of foam cells, Nceh1 may protect against the pro-apoptotic effect of oxysterols and modulate the development of atherosclerosis.	Oxysterols	123-133	neutral cholesterol ester hydrolase 1	Mus musculus	69-74
25255963-3	2014	Oxysterols are products of cholesterol oxidation that accumulate in conditions associated with increased cellular levels of reactive oxygen species, such as hypoxia and oxidative stress, activating LXR and inhibiting SREBP2.	Oxysterols	0-10	sterol regulatory element binding transcription factor 2	Homo sapiens	217-223
26461396-4	2014	Regarding atherosclerosis, we have observed that oxysterols can contribute to plaque instability and rupture by enhancing inflammatory responses and matrix turnover through an unbalanced up-regulation of MMP-9.	Oxysterols	49-59	matrix metallopeptidase 9	Homo sapiens	204-209
26461396-5	2014	Concerning AD, we have demonstrated that oxysterols may promote neuroinflammatory changes and accelerate APP processing toward beta-amyloid production by up-regulating APP and BACE1 protein levels.	Oxysterols	41-51	beta-secretase 1	Homo sapiens	176-181
25255026-1	2014	Oxysterol binding protein (OSBP) and OSBP-related proteins (ORPS) have a conserved lipid-binding fold that accommodates cholesterol, oxysterols and/or phospholipids.	Oxysterols	133-143	oxysterol binding protein	Homo sapiens	0-25
25255026-1	2014	Oxysterol binding protein (OSBP) and OSBP-related proteins (ORPS) have a conserved lipid-binding fold that accommodates cholesterol, oxysterols and/or phospholipids.	Oxysterols	133-143	oxysterol binding protein	Homo sapiens	27-31
25255026-1	2014	Oxysterol binding protein (OSBP) and OSBP-related proteins (ORPS) have a conserved lipid-binding fold that accommodates cholesterol, oxysterols and/or phospholipids.	Oxysterols	133-143	oxysterol binding protein	Homo sapiens	37-41
24881998-7	2014	Next, Bmi1 function was replaced with Shh activators (oxysterol and purmorphamine), which demonstrating that combinations of small molecules can compensate for reprogramming factors and are sufficient to directly reprogram mouse somatic cells into iPSLCs.	Oxysterols	54-63	sonic hedgehog	Mus musculus	38-41
25201972-7	2014	Resequencing, expression analysis, and biochemical experiments focused on one such locus (CYP39A1), revealed multiple loss-of-function alleles with additive effects on serum levels of the oxysterol, 24S-hydroxycholesterol, a substrate of the encoded enzyme.	Oxysterols	188-197	cytochrome P450 family 39 subfamily A member 1	Homo sapiens	90-97
25043692-3	2014	Recently oxysterols, which activate the Liver X Receptor (LXR), have been implicated in producing sEng, by upregulating matrix metalloproteinase-14 (MMP14; cleaves endoglin to produce sEng) and down-regulating tissue inhibitor of metalloproteinase-3 (TIMP-3; inhibitor of MMP14).	Oxysterols	9-19	matrix metallopeptidase 14	Homo sapiens	120-147
25043692-3	2014	Recently oxysterols, which activate the Liver X Receptor (LXR), have been implicated in producing sEng, by upregulating matrix metalloproteinase-14 (MMP14; cleaves endoglin to produce sEng) and down-regulating tissue inhibitor of metalloproteinase-3 (TIMP-3; inhibitor of MMP14).	Oxysterols	9-19	matrix metallopeptidase 14	Homo sapiens	149-154
25043692-3	2014	Recently oxysterols, which activate the Liver X Receptor (LXR), have been implicated in producing sEng, by upregulating matrix metalloproteinase-14 (MMP14; cleaves endoglin to produce sEng) and down-regulating tissue inhibitor of metalloproteinase-3 (TIMP-3; inhibitor of MMP14).	Oxysterols	9-19	endoglin	Homo sapiens	164-172
25043692-3	2014	Recently oxysterols, which activate the Liver X Receptor (LXR), have been implicated in producing sEng, by upregulating matrix metalloproteinase-14 (MMP14; cleaves endoglin to produce sEng) and down-regulating tissue inhibitor of metalloproteinase-3 (TIMP-3; inhibitor of MMP14).	Oxysterols	9-19	TIMP metallopeptidase inhibitor 3	Homo sapiens	210-249
25043692-3	2014	Recently oxysterols, which activate the Liver X Receptor (LXR), have been implicated in producing sEng, by upregulating matrix metalloproteinase-14 (MMP14; cleaves endoglin to produce sEng) and down-regulating tissue inhibitor of metalloproteinase-3 (TIMP-3; inhibitor of MMP14).	Oxysterols	9-19	TIMP metallopeptidase inhibitor 3	Homo sapiens	251-257
25043692-3	2014	Recently oxysterols, which activate the Liver X Receptor (LXR), have been implicated in producing sEng, by upregulating matrix metalloproteinase-14 (MMP14; cleaves endoglin to produce sEng) and down-regulating tissue inhibitor of metalloproteinase-3 (TIMP-3; inhibitor of MMP14).	Oxysterols	9-19	matrix metallopeptidase 14	Homo sapiens	272-277
24928400-5	2014	Here, we disclose detailed structure-activity relationships of oxysterol derivatives as pharmacological chaperones for NPC1(I1061T) mutant.	Oxysterols	63-72	NPC intracellular cholesterol transporter 1	Homo sapiens	119-123
24833118-2	2014	Efficient oxysterol removal by the sub-family G member 1 of the ATP-binding cassette transporters (ABCG1) is essential for cell survival and control of cellular processes.	Oxysterols	10-19	ATP binding cassette subfamily G member 1	Mus musculus	99-104
25072708-2	2014	In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression of the gene encoding mitochondrial cholesterol delivery protein (StarD1).	Oxysterols	77-86	steroidogenic acute regulatory protein	Rattus norvegicus	210-216
25072708-3	2014	Forty-eight hours after infection of the hepatocytes with recombinant StarD1 adenovirus, a water-soluble oxysterol product was isolated and purified by chemical extraction and reverse-phase HPLC.	Oxysterols	105-114	steroidogenic acute regulatory protein	Homo sapiens	70-76
24906511-4	2014	As an extension of that work, we aimed here to find non-steroidal NPC1L1 ligands, which may be better candidates for clinical application than steroidal ligands, by using the same assay to screen our focused library of ligands for liver X receptor (LXR), a nuclear receptor that recognizes oxysterols as endogenous ligands.	Oxysterols	290-300	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	66-72
24833118-4	2014	Here, we examined the involvement of ABCG1 in the oxysterol metabolism by studying oxysterol tissue levels in a mouse model of Abcg1-deficiency.	Oxysterols	50-59	ATP binding cassette subfamily G member 1	Mus musculus	37-42
24777958-4	2014	LXR-dependent oxysterol effects can be ascribed to the activation of LXRalpha, LXRbeta or LXRalphabeta isoforms, which induces transcriptional activation or trans-repression of target genes.	Oxysterols	14-23	nuclear receptor subfamily 1 group H member 3	Homo sapiens	69-77
24954418-2	2014	27-hydroxycholesterol (27HC) is an abundant oxysterol metabolized by CYP7B1.	Oxysterols	44-53	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	69-75
24954418-1	2014	Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands.	Oxysterols	0-10	nuclear receptor subfamily 1, group H, member 3	Mus musculus	103-119
24954418-1	2014	Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands.	Oxysterols	0-10	nuclear receptor subfamily 1, group H, member 3	Mus musculus	121-124
24810762-9	2014	We also summarize the structural and functional properties of EBI2 interaction with oxysterol agonists and small molecule antagonists and discuss EBI2 as therapeutic target for diseases of the immune system.	Oxysterols	84-93	G protein-coupled receptor 183	Homo sapiens	62-66
24777958-4	2014	LXR-dependent oxysterol effects can be ascribed to the activation of LXRalpha, LXRbeta or LXRalphabeta isoforms, which induces transcriptional activation or trans-repression of target genes.	Oxysterols	14-23	nuclear receptor subfamily 1 group H member 2	Homo sapiens	79-86
24620755-0	2014	The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits the toxic effect of this oxysterol on SH-SY5Y cells.	Oxysterols	109-118	lecithin-cholesterol acyltransferase	Homo sapiens	11-47
24620755-9	2014	These results suggest that the enzyme, in the presence of the apolipoproteins, converts 24(S)OH-C into esters restricted to the extracellular environment, thus preventing or limiting oxysterol-induced neurotoxic injuries to neurons in culture.	Oxysterols	183-192	apolipoprotein E	Homo sapiens	62-77
25228229-9	2014	Either in the presence or absence of calcium i) oxysterols inhibited APLT, ii) staurosporin, calphostin C, Z-DEVD-FMK blunted and iii) antioxidants fully prevented the oxysterol-induced PS externalization.	Oxysterols	48-58	ATPase phospholipid transporting 8A1	Homo sapiens	69-73
24612036-3	2014	The challenge of differentiated SK-N-BE human neuroblastoma cells with patho-physiologically relevant amounts of 27-OH and 24-OH showed that both oxysterols induce a net synthesis of Abeta1-42 by up-regulating expression levels of amyloid precursor protein and beta-secretase, as well as the beta-secretase activity.	Oxysterols	146-156	amyloid beta precursor protein	Homo sapiens	231-256
24612036-5	2014	The reported findings link an impaired cholesterol oxidative metabolism to an excessive beta-amyloidogenesis and point to NAC as an efficient inhibitor of oxysterols-induced Abeta toxic peptide accumulation in the brain.	Oxysterols	155-165	amyloid beta precursor protein	Homo sapiens	174-179
24480442-1	2014	Oxysterols such as 7 alpha, 25-dihydroxycholesterol (7alpha,25-OHC) are natural ligands for the Epstein-Barr virus (EBV)-induced gene 2 (EBI2, aka GPR183), a G protein-coupled receptor (GPCR) highly expressed in immune cells and required for adaptive immune responses.	Oxysterols	0-10	G protein-coupled receptor 183	Homo sapiens	137-141
24480442-7	2014	Supernatants of LPS-stimulated macrophages are able to stimulate EBI2 signaling indicating that an induction of CH25H, CYP27A1, and CYP7B1 results in an enhanced production and release of oxysterols into the cellular environment.	Oxysterols	188-198	G protein-coupled receptor 183	Homo sapiens	65-69
24480442-7	2014	Supernatants of LPS-stimulated macrophages are able to stimulate EBI2 signaling indicating that an induction of CH25H, CYP27A1, and CYP7B1 results in an enhanced production and release of oxysterols into the cellular environment.	Oxysterols	188-198	cholesterol 25-hydroxylase	Homo sapiens	112-117
24480442-7	2014	Supernatants of LPS-stimulated macrophages are able to stimulate EBI2 signaling indicating that an induction of CH25H, CYP27A1, and CYP7B1 results in an enhanced production and release of oxysterols into the cellular environment.	Oxysterols	188-198	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	119-126
24480442-7	2014	Supernatants of LPS-stimulated macrophages are able to stimulate EBI2 signaling indicating that an induction of CH25H, CYP27A1, and CYP7B1 results in an enhanced production and release of oxysterols into the cellular environment.	Oxysterols	188-198	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	132-138
24491562-0	2014	Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse.	Oxysterols	0-10	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	31-57
24424245-0	2014	OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle.	Oxysterols	106-115	oxysterol binding protein like 8	Homo sapiens	0-22
24424245-0	2014	OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle.	Oxysterols	106-115	oxysterol binding protein like 8	Homo sapiens	24-28
24424245-0	2014	OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle.	Oxysterols	106-115	sperm associated antigen 5	Homo sapiens	58-84
24491228-2	2014	CYP7B1 catalyzes the 6- or 7-hydroxylation of both steroids and oxysterols and thus is involved in the metabolism of neurosteroids and bile acid synthesis, respectively.	Oxysterols	64-74	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
23896203-10	2014	In addition, analyzing a mouse SLOS model revealed that feeding a vitamin E enriched diet to pregnant female mice led to a decrease in oxysterol formation in brain and liver tissues of the newborn Dhcr7-knockout pups.	Oxysterols	135-144	7-dehydrocholesterol reductase	Mus musculus	197-202
24370436-5	2014	27-Hydroxycholesterol and 7alpha-hydroxycholesterol, cholesterol oxides (oxysterols) detected in abundance in atherosclerotic lesions, greatly induced the transcription of CCL3 and CCL4 genes in addition to enhancing secretion of corresponding proteins by THP-1 monocytic cells.	Oxysterols	73-83	chemokine (C-C motif) ligand 3	Mus musculus	172-176
24370436-5	2014	27-Hydroxycholesterol and 7alpha-hydroxycholesterol, cholesterol oxides (oxysterols) detected in abundance in atherosclerotic lesions, greatly induced the transcription of CCL3 and CCL4 genes in addition to enhancing secretion of corresponding proteins by THP-1 monocytic cells.	Oxysterols	73-83	chemokine (C-C motif) ligand 4	Mus musculus	181-185
24963104-5	2014	The objective of the present study was to determine the contribution of the oxysterol-induced pro-apoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP) on the pathogenesis of CKD-dependent cardiovascular diseases through endoplasmic reticulum stress signaling.	Oxysterols	76-85	DNA damage inducible transcript 3	Homo sapiens	129-178
24963104-5	2014	The objective of the present study was to determine the contribution of the oxysterol-induced pro-apoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP) on the pathogenesis of CKD-dependent cardiovascular diseases through endoplasmic reticulum stress signaling.	Oxysterols	76-85	DNA damage inducible transcript 3	Homo sapiens	180-184
24963104-9	2014	The short hairpin RNA-mediated knockdown of CHOP and activating transcription factor-4 in vascular smooth muscle cells attenuated oxysterol-induced mineralization, osteogenic differentiation, and endoplasmic reticulum stress.	Oxysterols	130-139	DNA damage inducible transcript 3	Homo sapiens	44-48
24963104-9	2014	The short hairpin RNA-mediated knockdown of CHOP and activating transcription factor-4 in vascular smooth muscle cells attenuated oxysterol-induced mineralization, osteogenic differentiation, and endoplasmic reticulum stress.	Oxysterols	130-139	activating transcription factor 4	Homo sapiens	53-86
24671012-5	2014	Treatment of macrophages with oxysterols or loading with modified LDL induces LBP in an LXR-dependent manner, suggesting a potential role for LBP in the cellular response to cholesterol overload.	Oxysterols	30-40	lipopolysaccharide binding protein	Homo sapiens	78-81
24671012-5	2014	Treatment of macrophages with oxysterols or loading with modified LDL induces LBP in an LXR-dependent manner, suggesting a potential role for LBP in the cellular response to cholesterol overload.	Oxysterols	30-40	lipopolysaccharide binding protein	Homo sapiens	142-145
24491562-3	2014	Despite a great reduction in the abundance of 24S-hydroxycholesterol, the dominant metabolite of cholesterol in wild type brain, no other cholesterol metabolite was found to quantitatively replace this oxysterol in the Cyp46a1-/- mouse.	Oxysterols	202-211	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	219-226
24625033-6	2014	By comparing the oxysterol profile formed from 7-DHC and those formed from 8-DHC and 5,8(14)-dienol, products formed from abstraction of the hydrogen atoms at C-9 and C-14 (H-9 or H-14 mechanism) were clearly differentiated.	Oxysterols	17-26	complement C9	Homo sapiens	159-162
24491228-7	2014	Metabolic conversion (deactivation) of oxysterols by CYP7B1 in a reconstituted system proceeds via two sequential hydroxylations.	Oxysterols	39-49	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	53-59
24280213-5	2014	The oxysterol 27-hydroxycholesterol (27HC), synthesized by the mitochondrial enzyme CYP27A1, was identified as one of the major de novo adipocyte products from cholesterol and its precursor mevalonate.	Oxysterols	4-13	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	84-91
25228229-9	2014	Either in the presence or absence of calcium i) oxysterols inhibited APLT, ii) staurosporin, calphostin C, Z-DEVD-FMK blunted and iii) antioxidants fully prevented the oxysterol-induced PS externalization.	Oxysterols	48-57	ATPase phospholipid transporting 8A1	Homo sapiens	69-73
24320932-1	2013	ATP-binding cassette transporter G1 (ABCG1) mediates cholesterol and oxysterol efflux onto lipidated lipoproteins and plays an important role in macrophage reverse cholesterol transport.	Oxysterols	69-78	ATP binding cassette subfamily G member 1	Homo sapiens	0-35
24672716-8	2014	Interestingly, the appearance of the large HDL1 lipoprotein was observed with increased oxysterol synthesis during obesity.	Oxysterols	88-97	high density lipoprotein (HDL) level 1	Mus musculus	43-47
24320932-1	2013	ATP-binding cassette transporter G1 (ABCG1) mediates cholesterol and oxysterol efflux onto lipidated lipoproteins and plays an important role in macrophage reverse cholesterol transport.	Oxysterols	69-78	ATP binding cassette subfamily G member 1	Homo sapiens	37-42
24163426-8	2013	Inhibiting ACAT2 leads to the intracellular accumulation of unesterified oxysterols and suppresses the growth of both HCC cell lines and their xenograft tumors.	Oxysterols	73-83	acetyl-CoA acetyltransferase 2	Homo sapiens	11-16
24171105-2	2013	We present the 2.3 A crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show that it binds to oxysterols, endogenous lipids that activate Hh signaling.	Oxysterols	131-141	smoothened, frizzled class receptor	Homo sapiens	101-104
23800382-0	2013	The effect of oxysterols on the interaction of Alzheimer"s amyloid beta with model membranes.	Oxysterols	14-24	amyloid beta precursor protein	Homo sapiens	59-71
23800382-2	2013	However, the effect of cholesterol and its oxidized derivatives, oxysterols, on Abeta-induced neurotoxicity to membranes is not fully understood.	Oxysterols	65-75	amyloid beta precursor protein	Homo sapiens	80-85
23800382-4	2013	Our results have indicated that oxysterols rendered membranes more sensitive to Abeta, in contrast to role of cholesterol in inhibiting Abeta/membrane interaction.	Oxysterols	32-42	amyloid beta precursor protein	Homo sapiens	80-85
23800382-8	2013	These findings suggest the enhancing effect of oxysterols on interaction of Abeta with membranes and contribute to clarify the harmful impact of cholesterol on Abeta-induced neurotoxicity by means of its oxidation.	Oxysterols	47-57	amyloid beta precursor protein	Homo sapiens	76-81
24171105-3	2013	The oxysterol-binding groove in the Smo CRD is analogous to that used by Frizzled 8 to bind to the palmitoleyl group of Wnt ligands and to similar pockets used by other Frizzled-like CRDs to bind hydrophobic ligands.	Oxysterols	4-13	smoothened, frizzled class receptor	Homo sapiens	36-39
24171105-5	2013	Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants.	Oxysterols	36-45	smoothened, frizzled class receptor	Homo sapiens	25-28
24171105-5	2013	Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants.	Oxysterols	36-45	smoothened, frizzled class receptor	Homo sapiens	156-159
23729662-0	2013	Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase.	Oxysterols	0-9	adenylate cyclase 10	Rattus norvegicus	77-101
23979132-10	2013	Nevertheless, cholesterol-free oxLDL and unmodified cholesterol (20 mug/ml) induce only HAS3 transcription, whereas 22,oxysterol affects both HAS2 and HAS3.	Oxysterols	119-128	hyaluronan synthase 2	Homo sapiens	142-146
23979132-10	2013	Nevertheless, cholesterol-free oxLDL and unmodified cholesterol (20 mug/ml) induce only HAS3 transcription, whereas 22,oxysterol affects both HAS2 and HAS3.	Oxysterols	119-128	hyaluronan synthase 3	Homo sapiens	151-155
23831332-3	2013	Prolonged application of oxysterol significantly enhanced LPS-stimulated association of cytosolic NADPH-oxidase factor p47[phox] with detergent-resistant microdomains (DRMs) in BV-2 cells.	Oxysterols	25-34	NSFL1 (p97) cofactor (p47)	Mus musculus	119-122
24069433-7	2013	Expression of ORP4S, an ORP4 variant that lacked the N-terminal pleckstrin-homology domain but contained the C-terminal oxysterol-binding domain also inhibited HCV replication, pointing to an important role of the oxysterol-binding domain in ORP4-mediated inhibition of HCV replication.	Oxysterols	120-129	oxysterol binding protein 2	Homo sapiens	14-18
24069433-7	2013	Expression of ORP4S, an ORP4 variant that lacked the N-terminal pleckstrin-homology domain but contained the C-terminal oxysterol-binding domain also inhibited HCV replication, pointing to an important role of the oxysterol-binding domain in ORP4-mediated inhibition of HCV replication.	Oxysterols	214-223	oxysterol binding protein 2	Homo sapiens	14-18
23729662-9	2013	sAC expression in the cytosol, but not in mitochondria, significantly promoted apoptosis and ROS formation during oxysterol treatment.	Oxysterols	114-123	adenylate cyclase 10	Rattus norvegicus	0-3
23729662-10	2013	CONCLUSION: These results suggest that the sAC/PKA axis plays a key role in the oxysterol-induced apoptosis of VSMC by controlling mitochondrial Bax translocation and ROS formation and that cytosolic sAC, rather than the mitochondrial pool, is involved in the apoptotic mechanism.	Oxysterols	80-89	adenylate cyclase 10	Rattus norvegicus	43-46
23729662-10	2013	CONCLUSION: These results suggest that the sAC/PKA axis plays a key role in the oxysterol-induced apoptosis of VSMC by controlling mitochondrial Bax translocation and ROS formation and that cytosolic sAC, rather than the mitochondrial pool, is involved in the apoptotic mechanism.	Oxysterols	80-89	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	47-50
23729662-10	2013	CONCLUSION: These results suggest that the sAC/PKA axis plays a key role in the oxysterol-induced apoptosis of VSMC by controlling mitochondrial Bax translocation and ROS formation and that cytosolic sAC, rather than the mitochondrial pool, is involved in the apoptotic mechanism.	Oxysterols	80-89	BCL2 associated X, apoptosis regulator	Rattus norvegicus	145-148
23729662-5	2013	Oxysterols treatment led to the activation of the mitochondrial pathway of apoptosis (cytochrome c release and caspase-9 cleavage) and mitochondrial ROS formation, which were suppressed by the pharmacological inhibition or knockdown of sAC.	Oxysterols	0-10	caspase 9	Rattus norvegicus	111-120
23729662-5	2013	Oxysterols treatment led to the activation of the mitochondrial pathway of apoptosis (cytochrome c release and caspase-9 cleavage) and mitochondrial ROS formation, which were suppressed by the pharmacological inhibition or knockdown of sAC.	Oxysterols	0-10	adenylate cyclase 10	Rattus norvegicus	236-239
23729662-7	2013	Analyses of the downstream pathway suggest that protein kinase A (PKA)-dependent phosphorylation and the mitochondrial translocation of the pro-apoptotic protein Bax is a key link between sAC and oxysterol-induced ROS formation and apoptosis.	Oxysterols	196-205	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	48-64
23729662-7	2013	Analyses of the downstream pathway suggest that protein kinase A (PKA)-dependent phosphorylation and the mitochondrial translocation of the pro-apoptotic protein Bax is a key link between sAC and oxysterol-induced ROS formation and apoptosis.	Oxysterols	196-205	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	66-69
23729662-7	2013	Analyses of the downstream pathway suggest that protein kinase A (PKA)-dependent phosphorylation and the mitochondrial translocation of the pro-apoptotic protein Bax is a key link between sAC and oxysterol-induced ROS formation and apoptosis.	Oxysterols	196-205	BCL2 associated X, apoptosis regulator	Rattus norvegicus	162-165
23729662-7	2013	Analyses of the downstream pathway suggest that protein kinase A (PKA)-dependent phosphorylation and the mitochondrial translocation of the pro-apoptotic protein Bax is a key link between sAC and oxysterol-induced ROS formation and apoptosis.	Oxysterols	196-205	adenylate cyclase 10	Rattus norvegicus	188-191
23665353-8	2013	The rapid inhibition of platelet reactivity to collagen by natural and pharmacologic LXR agonists offers a mechanism that could attenuate platelet activation by denuded plaques that expose collagen and LXR agonistic oxysterols.	Oxysterols	216-226	nuclear receptor subfamily 1, group H, member 3	Mus musculus	85-88
23831757-3	2013	We developed azasterols that block Hh signaling by binding the oxysterol-binding site of Smo.	Oxysterols	63-72	smoothened, frizzled class receptor	Homo sapiens	89-92
23831757-4	2013	We show that the binding site for oxysterols and azasterols maps to the extracellular, cysteine-rich domain of Smo and is completely separable from the site bound by other small-molecule modulators, located within the heptahelical bundle of Smo.	Oxysterols	34-44	smoothened, frizzled class receptor	Homo sapiens	111-114
23831757-4	2013	We show that the binding site for oxysterols and azasterols maps to the extracellular, cysteine-rich domain of Smo and is completely separable from the site bound by other small-molecule modulators, located within the heptahelical bundle of Smo.	Oxysterols	34-44	smoothened, frizzled class receptor	Homo sapiens	241-244
23831757-5	2013	Smo mutants in which oxysterol binding is abolished no longer respond to oxysterols and cannot be maximally activated by the Hh ligand.	Oxysterols	21-30	smoothened, frizzled class receptor	Homo sapiens	0-3
23831757-5	2013	Smo mutants in which oxysterol binding is abolished no longer respond to oxysterols and cannot be maximally activated by the Hh ligand.	Oxysterols	73-83	smoothened, frizzled class receptor	Homo sapiens	0-3
23831757-6	2013	Our results show that oxysterol binding to vertebrate Smo is required for normal Hh signaling and that targeting the oxysterol-binding site is an effective strategy to inhibit Smo.	Oxysterols	22-31	smoothened, frizzled class receptor	Homo sapiens	54-57
23831757-6	2013	Our results show that oxysterol binding to vertebrate Smo is required for normal Hh signaling and that targeting the oxysterol-binding site is an effective strategy to inhibit Smo.	Oxysterols	22-31	smoothened, frizzled class receptor	Homo sapiens	176-179
23831757-6	2013	Our results show that oxysterol binding to vertebrate Smo is required for normal Hh signaling and that targeting the oxysterol-binding site is an effective strategy to inhibit Smo.	Oxysterols	117-126	smoothened, frizzled class receptor	Homo sapiens	176-179
23954590-2	2013	Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful synthetic mimics) and hydroxylated cholesterol derivatives (oxysterols); Smo is also highly sensitive to cellular sterol levels.	Oxysterols	173-183	smoothened, frizzled class receptor	Homo sapiens	10-13
23954590-2	2013	Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful synthetic mimics) and hydroxylated cholesterol derivatives (oxysterols); Smo is also highly sensitive to cellular sterol levels.	Oxysterols	173-183	smoothened, frizzled class receptor	Homo sapiens	186-189
23954590-4	2013	We identify the conserved extracellular cysteine-rich domain (CRD) as the site of action for oxysterols on Smo, involving residues structurally analogous to those contacting the Wnt lipid adduct in the homologous Frizzled CRD; this modulatory effect is distinct from that of cyclopamine mimics, from Hh-mediated regulation, and from the permissive action of cellular sterol pools.	Oxysterols	93-103	smoothened, frizzled class receptor	Homo sapiens	107-110
23665353-8	2013	The rapid inhibition of platelet reactivity to collagen by natural and pharmacologic LXR agonists offers a mechanism that could attenuate platelet activation by denuded plaques that expose collagen and LXR agonistic oxysterols.	Oxysterols	216-226	nuclear receptor subfamily 1, group H, member 3	Mus musculus	202-205
23524238-6	2013	For example, ABC transporters have been shown to protect against the harmful effects of hypoxia and oxidative stress through increased expression and efflux of oxysterols and glutathione conjugated xenobiotics.	Oxysterols	160-170	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	13-16
23791945-0	2013	Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins.	Oxysterols	74-83	oxysterol-binding protein related protein OSH3	Saccharomyces cerevisiae S288C	13-17
23583258-3	2013	This report concerns the marked up-regulation in differentiated CaCo-2 colonic epithelial cells of two key inflammatory interleukins, IL-6 and IL-8, caused by a mixture of oxysterols representative of a high cholesterol diet.	Oxysterols	172-182	interleukin 6	Homo sapiens	134-138
23583258-3	2013	This report concerns the marked up-regulation in differentiated CaCo-2 colonic epithelial cells of two key inflammatory interleukins, IL-6 and IL-8, caused by a mixture of oxysterols representative of a high cholesterol diet.	Oxysterols	172-182	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
23583258-6	2013	Oxysterol-dependent NOX1 activation, as well as interleukin synthesis, were completely prevented by Cannonau red wine extract that contains an abundant phenolic fraction, in particular phenolic acids and flavonoids.	Oxysterols	0-9	NADPH oxidase 1	Homo sapiens	20-24
23583258-9	2013	Besides this direct activity, an excess of phenolic compounds detectable in red wine, may exert an additional indirect action by blocking oxysterol-related NOX1 induction, thus totally preventing the pro-oxidant and pro-inflammatory events triggered by dietary oxysterols.	Oxysterols	138-147	NADPH oxidase 1	Homo sapiens	156-160
24069554-6	2013	STAT1 was shown to be the most essential transcriptional factor involved in the induction of cholesterol 25-hydroxylase (Ch25h), the enzyme required to produce 25HC, indicating the importance of STAT1 in oxysterol-mediated innate immunity.	Oxysterols	204-213	signal transducer and activator of transcription 1	Homo sapiens	0-5
24069554-6	2013	STAT1 was shown to be the most essential transcriptional factor involved in the induction of cholesterol 25-hydroxylase (Ch25h), the enzyme required to produce 25HC, indicating the importance of STAT1 in oxysterol-mediated innate immunity.	Oxysterols	204-213	cholesterol 25-hydroxylase	Homo sapiens	93-119
24069554-6	2013	STAT1 was shown to be the most essential transcriptional factor involved in the induction of cholesterol 25-hydroxylase (Ch25h), the enzyme required to produce 25HC, indicating the importance of STAT1 in oxysterol-mediated innate immunity.	Oxysterols	204-213	cholesterol 25-hydroxylase	Homo sapiens	121-126
24069554-6	2013	STAT1 was shown to be the most essential transcriptional factor involved in the induction of cholesterol 25-hydroxylase (Ch25h), the enzyme required to produce 25HC, indicating the importance of STAT1 in oxysterol-mediated innate immunity.	Oxysterols	204-213	signal transducer and activator of transcription 1	Homo sapiens	195-200
23806956-8	2013	Expression of osteocalcin and osteopontin in cells treated with oxysterol 49 and BMP-2 was equivalent.	Oxysterols	64-73	osteocalcin	Oryctolagus cuniculus	14-25
23806956-8	2013	Expression of osteocalcin and osteopontin in cells treated with oxysterol 49 and BMP-2 was equivalent.	Oxysterols	64-73	osteopontin	Oryctolagus cuniculus	30-41
23579488-2	2013	Sulfotransferase 2B1b (SULT2B1b) (in short, SULT2B) is a prostate-expressed hydroxysteroid SULT that converts cholesterol, oxysterols, and DHEA to 3beta-sulfates.	Oxysterols	123-133	sulfotransferase family, cytosolic, 2B, member 1	Mus musculus	23-29
23682316-3	2013	Here we show that CD4(+) DCs highly express EBI2 and migrate to its oxysterol ligand, 7alpha,25-OHC.	Oxysterols	68-77	CD4 antigen	Mus musculus	18-21
23682316-3	2013	Here we show that CD4(+) DCs highly express EBI2 and migrate to its oxysterol ligand, 7alpha,25-OHC.	Oxysterols	68-77	G protein-coupled receptor 183	Mus musculus	44-48
23473804-9	2013	Thus, in 158N cells, the ability of oxysterols to trigger a mode of cell death by apoptosis involving GSK-3 and caspase-3 activation is independent of the increase in the Ca(2+) level and of their accumulation in lipid raft microdomains.	Oxysterols	36-46	glycogen synthase kinase 3 beta	Mus musculus	102-107
23473804-9	2013	Thus, in 158N cells, the ability of oxysterols to trigger a mode of cell death by apoptosis involving GSK-3 and caspase-3 activation is independent of the increase in the Ca(2+) level and of their accumulation in lipid raft microdomains.	Oxysterols	36-46	caspase 3	Mus musculus	112-121
23554458-7	2013	Administration of the selective TSPO ligand 4"-chlorodiazepam inhibited oxidative stress, improved mitochondrial function, and abolished both mitochondrial cholesterol accumulation and oxysterol production.	Oxysterols	185-194	translocator protein	Rattus norvegicus	32-36
23298226-2	2013	Mitochondrial cholesterol transport is rate-limiting in the CYP27A1 (sterol 27-hydroxylase)-dependent generation of oxysterol ligands for LXR (liver X receptor) transcription factors that regulate the expression of genes encoding proteins in the cholesterol efflux pathway, such as ABC transporters (ATP-binding cassette transporters) ABCA1 and ABCG1.	Oxysterols	116-125	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	60-67
22884520-3	2013	Defects resulting in slowed release of cholesterol from late endosomes and lysosomes or reduction in sterol-27-hydroxylase activity lead to specific blocks in oxysterol production and impaired LXR-dependent gene activation.	Oxysterols	159-168	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	101-122
23298226-2	2013	Mitochondrial cholesterol transport is rate-limiting in the CYP27A1 (sterol 27-hydroxylase)-dependent generation of oxysterol ligands for LXR (liver X receptor) transcription factors that regulate the expression of genes encoding proteins in the cholesterol efflux pathway, such as ABC transporters (ATP-binding cassette transporters) ABCA1 and ABCG1.	Oxysterols	116-125	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	69-90
23298226-2	2013	Mitochondrial cholesterol transport is rate-limiting in the CYP27A1 (sterol 27-hydroxylase)-dependent generation of oxysterol ligands for LXR (liver X receptor) transcription factors that regulate the expression of genes encoding proteins in the cholesterol efflux pathway, such as ABC transporters (ATP-binding cassette transporters) ABCA1 and ABCG1.	Oxysterols	116-125	ATP binding cassette subfamily A member 1	Homo sapiens	335-340
23298226-2	2013	Mitochondrial cholesterol transport is rate-limiting in the CYP27A1 (sterol 27-hydroxylase)-dependent generation of oxysterol ligands for LXR (liver X receptor) transcription factors that regulate the expression of genes encoding proteins in the cholesterol efflux pathway, such as ABC transporters (ATP-binding cassette transporters) ABCA1 and ABCG1.	Oxysterols	116-125	ATP binding cassette subfamily G member 1	Homo sapiens	345-350
23298226-5	2013	In turn, this will trigger opening of the permeability transition pore, allowing unregulated production of oxysterols via CYP27A1, allowing the accumulation of esterified forms of this oxysterol within human atherosclerotic lesions.	Oxysterols	107-117	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	122-129
23298226-5	2013	In turn, this will trigger opening of the permeability transition pore, allowing unregulated production of oxysterols via CYP27A1, allowing the accumulation of esterified forms of this oxysterol within human atherosclerotic lesions.	Oxysterols	107-116	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	122-129
23284090-2	2013	The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.	Oxysterols	8-18	nuclear receptor subfamily 1, group H, member 3	Mus musculus	151-167
23381570-1	2013	Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3beta-hydroxysterol-Delta(7)-reductase (DHCR7).	Oxysterols	65-75	7-dehydrocholesterol reductase	Mus musculus	247-252
23284090-2	2013	The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.	Oxysterols	8-18	nuclear receptor subfamily 1, group H, member 3	Mus musculus	169-172
23063693-3	2013	LXRs and PPARalpha are regulated by endogenous ligands, oxysterols and fatty acid derived molecules, respectively.	Oxysterols	56-66	peroxisome proliferator activated receptor alpha	Mus musculus	9-18
23521797-0	2013	Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site.	Oxysterols	13-22	NPC intracellular cholesterol transporter 1	Homo sapiens	62-66
23521797-5	2013	These oxysterol derivatives bind to a domain of NPC1 that is different from the known N-terminal sterol-binding domain; i.e., there is an additional sterol-binding site on NPC1.	Oxysterols	6-15	NPC intracellular cholesterol transporter 1	Homo sapiens	48-52
23521797-5	2013	These oxysterol derivatives bind to a domain of NPC1 that is different from the known N-terminal sterol-binding domain; i.e., there is an additional sterol-binding site on NPC1.	Oxysterols	6-15	NPC intracellular cholesterol transporter 1	Homo sapiens	172-176
22940536-8	2013	This activity was lost in aorta from 11beta-HSD1(-/-) mice, which had low oxysterol levels.	Oxysterols	74-83	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	37-48
23362264-9	2013	Cells overexpressing HSL increased the efficacy of liver X receptor (LXR) ligands on StAR expression and steroid synthesis, suggesting HSL-mediated steroidogenesis entails enhanced oxysterol production.	Oxysterols	181-190	lipase, hormone sensitive	Mus musculus	21-24
23362264-9	2013	Cells overexpressing HSL increased the efficacy of liver X receptor (LXR) ligands on StAR expression and steroid synthesis, suggesting HSL-mediated steroidogenesis entails enhanced oxysterol production.	Oxysterols	181-190	nuclear receptor subfamily 1, group H, member 3	Mus musculus	51-67
23362264-9	2013	Cells overexpressing HSL increased the efficacy of liver X receptor (LXR) ligands on StAR expression and steroid synthesis, suggesting HSL-mediated steroidogenesis entails enhanced oxysterol production.	Oxysterols	181-190	nuclear receptor subfamily 1, group H, member 3	Mus musculus	69-72
23362264-9	2013	Cells overexpressing HSL increased the efficacy of liver X receptor (LXR) ligands on StAR expression and steroid synthesis, suggesting HSL-mediated steroidogenesis entails enhanced oxysterol production.	Oxysterols	181-190	lipase, hormone sensitive	Mus musculus	135-138
22960205-6	2013	The effects of long-term exposure to the oxysterol congener 7beta-hydroxycholesterol on arginine vasopressin stimulated Ca(2+) signals were mainly at the level of Ca(2+) release from intracellular stores rather than on Ca(2+) influx mechanisms.	Oxysterols	41-50	arginine vasopressin	Rattus norvegicus	97-108
22960205-7	2013	Of the calcium signalling proteins tested, only the type 1 ryanodine receptor and the type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R1) were significantly downregulated by 24 h exposure to oxysterols.	Oxysterols	194-204	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	132-139
23092829-4	2013	Sixty muM oxysterol mixture showed a slight pro-apoptotic effect on human colon cancer CaCo-2 cell line, evaluated in terms of caspase-3 and caspase-7 activation; conversely, 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol and 5alpha,6alpha-epoxycholesterol were identified to be able to induce a significant pro-apoptotic effect if added to cell culture singly; 7beta-hydroxycholesterol had stronger action than other compounds.	Oxysterols	10-19	latexin	Homo sapiens	6-9
23092829-4	2013	Sixty muM oxysterol mixture showed a slight pro-apoptotic effect on human colon cancer CaCo-2 cell line, evaluated in terms of caspase-3 and caspase-7 activation; conversely, 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol and 5alpha,6alpha-epoxycholesterol were identified to be able to induce a significant pro-apoptotic effect if added to cell culture singly; 7beta-hydroxycholesterol had stronger action than other compounds.	Oxysterols	10-19	caspase 3	Homo sapiens	127-136
23092829-4	2013	Sixty muM oxysterol mixture showed a slight pro-apoptotic effect on human colon cancer CaCo-2 cell line, evaluated in terms of caspase-3 and caspase-7 activation; conversely, 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol and 5alpha,6alpha-epoxycholesterol were identified to be able to induce a significant pro-apoptotic effect if added to cell culture singly; 7beta-hydroxycholesterol had stronger action than other compounds.	Oxysterols	10-19	caspase 7	Homo sapiens	141-150
23092829-5	2013	The enhanced production of reactive oxygen species through up-regulation of the colonic NADPH-oxidase isoform NOX1 appeared to be the key event in oxysterol-induced apoptosis in these colon cancer cells.	Oxysterols	147-156	NADPH oxidase 1	Homo sapiens	110-114
23092829-7	2013	Only MCP-1 production was significantly induced by 7beta-hydroxycholesterol, as well as by cholesterol and oxysterol mixture.	Oxysterols	107-116	C-C motif chemokine ligand 2	Homo sapiens	5-10
23092829-8	2013	However, oxysterol-induced inflammation appeared to be NOX1-independent, suggesting a secondary role of this enzyme in inducing inflammation in colon cancer cells.	Oxysterols	9-18	NADPH oxidase 1	Homo sapiens	55-59
22569763-7	2012	Serum proportions of liver X receptor alpha (LXRalpha) ligand oxysterols (ratios to cholesterol) were significantly elevated in the NAFLD patients compared to the controls.	Oxysterols	62-72	nuclear receptor subfamily 1 group H member 3	Homo sapiens	45-53
23203064-0	2012	Molecular signaling involved in oxysterol-induced beta1-integrin over-expression in human macrophages.	Oxysterols	32-41	integrin subunit beta 1	Homo sapiens	50-64
23203064-4	2012	This study demonstrates the effect of an oxysterol mixture, compatible with that detectable in human hypercholesterolemic plasma, on the expression and synthesis of beta(1)-integrin in cells of the macrophage lineage.	Oxysterols	41-50	integrin subunit beta 1	Homo sapiens	165-181
23772388-0	2013	Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation.	Oxysterols	29-38	G protein-coupled receptor 183	Homo sapiens	82-86
23333380-4	2013	Furthermore, we show that in the presence of shh agonists (oxysterol and purmophamine), which replaces the function of Bmi1, a single transcription factor, Nanog is sufficient to reprogram mouse fibroblasts into iPSCs.	Oxysterols	59-68	Bmi1 polycomb ring finger oncogene	Mus musculus	119-123
23333380-4	2013	Furthermore, we show that in the presence of shh agonists (oxysterol and purmophamine), which replaces the function of Bmi1, a single transcription factor, Nanog is sufficient to reprogram mouse fibroblasts into iPSCs.	Oxysterols	59-68	Nanog homeobox	Mus musculus	156-161
23115269-4	2013	Incubation of bicarbonate treated sperm with oxysterol-binding proteins (ORP-1 or ORP-2) caused a reduction of &gt;70% of the formed oxysterols in the sperm pellet but no free sterol depletion.	Oxysterols	133-143	oxysterol binding protein like 1A	Homo sapiens	73-78
23115269-4	2013	Incubation of bicarbonate treated sperm with oxysterol-binding proteins (ORP-1 or ORP-2) caused a reduction of &gt;70% of the formed oxysterols in the sperm pellet but no free sterol depletion.	Oxysterols	133-143	oxysterol binding protein like 2	Homo sapiens	82-87
23246833-7	2013	This is the first report demonstrating enhanced production of TNF-alpha in macrophages by treatment with oxysterols which are detected in abundance in atheromatous lesions; in addition, results of the current study provide evidence indicating that certain types of oxysterols contribute to development of atherosclerosis by promoting production of proinflammatory cytokines.	Oxysterols	105-115	tumor necrosis factor	Homo sapiens	62-71
23246833-7	2013	This is the first report demonstrating enhanced production of TNF-alpha in macrophages by treatment with oxysterols which are detected in abundance in atheromatous lesions; in addition, results of the current study provide evidence indicating that certain types of oxysterols contribute to development of atherosclerosis by promoting production of proinflammatory cytokines.	Oxysterols	265-275	tumor necrosis factor	Homo sapiens	62-71
23239817-7	2013	Notably, we identified decreased expression of the mRNA encoding cholesterol 25-hydroxylase (Ch25h), an enzyme that converts cholesterol to 25-hydroxycholesterol (25HC), an oxysterol with emerging roles in immunity.	Oxysterols	173-182	cholesterol 25-hydroxylase	Mus musculus	65-91
23239817-7	2013	Notably, we identified decreased expression of the mRNA encoding cholesterol 25-hydroxylase (Ch25h), an enzyme that converts cholesterol to 25-hydroxycholesterol (25HC), an oxysterol with emerging roles in immunity.	Oxysterols	173-182	cholesterol 25-hydroxylase	Mus musculus	93-98
23211426-4	2013	Liver X Receptor (LXR) alpha and LXR beta are nuclear receptors activated by oxysterols, oxidized derivatives of cholesterol.	Oxysterols	77-87	nuclear receptor subfamily 1 group H member 2	Homo sapiens	33-41
22985798-9	2012	Subsequent p53 nuclear translocation and induction of wild-type and phosphorylated p53 are early steps in oxysterol-induced lysosomal-mitochondrial pathways involved in cell death.	Oxysterols	106-115	tumor protein p53	Homo sapiens	11-14
22985798-9	2012	Subsequent p53 nuclear translocation and induction of wild-type and phosphorylated p53 are early steps in oxysterol-induced lysosomal-mitochondrial pathways involved in cell death.	Oxysterols	106-115	tumor protein p53	Homo sapiens	83-86
23110859-0	2012	Oxysterol-induced soluble endoglin release and its involvement in hypertension.	Oxysterols	0-9	endoglin	Mus musculus	26-34
23110859-9	2012	Finally, administration of an endoglin peptide containing the consensus matrix metalloproteinase-14 cleavage site G-L prevented the oxysterol-dependent increase in arterial pressure and sEng levels in mice.	Oxysterols	132-141	endoglin	Mus musculus	30-38
22569763-12	2012	CONCLUSIONS: We speculate that serum LXRalpha ligand oxysterol levels (relative to cholesterol) could be surrogate markers of insulin resistance, and that high oxysterol levels in the circulation may play an important role in the development of hepatic and peripheral insulin resistance followed by NAFLD.	Oxysterols	53-62	nuclear receptor subfamily 1 group H member 3	Homo sapiens	37-45
22999953-7	2012	These findings establish that CYP7B1 and HSD3B7, as well as CH25H, have essential roles in controlling oxysterol production in lymphoid tissues, and they suggest that differential enzyme expression in stromal cell subsets establishes 7alpha,25-OHC gradients required for B cell responses.	Oxysterols	103-112	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	30-36
22732306-9	2012	CONCLUSIONS: 25HC3S may be a potent regulator of hepatocyte proliferation and oxysterol sulfation may represent a novel regulatory pathway in liver proliferation via inactivating LXR signaling.	Oxysterols	78-87	nuclear receptor subfamily 1, group H, member 3	Mus musculus	179-182
22875855-12	2012	In conclusion, we present the first molecular characterization of oxysterol binding to a 7TM receptor and identify position II:20/2.60 as a generally important residue for ligand binding in certain 7TM receptors.	Oxysterols	66-75	cholinergic receptor muscarinic 2	Homo sapiens	89-101
22751695-2	2012	Primary macrophages from insulin-resistant ob/ob and insulin receptor (Insr)(-/-) mice display increased apoptosis in response to loading with free cholesterol or oxysterol, but underlying mechanisms have not been elucidated.	Oxysterols	163-172	insulin receptor	Mus musculus	53-69
22751695-2	2012	Primary macrophages from insulin-resistant ob/ob and insulin receptor (Insr)(-/-) mice display increased apoptosis in response to loading with free cholesterol or oxysterol, but underlying mechanisms have not been elucidated.	Oxysterols	163-172	insulin receptor	Mus musculus	71-75
22914792-5	2012	Sterol and oxysterol enhance endothelial cav-1/eNOS interaction and suppress NO production, but these effects are reversed by apoE.	Oxysterols	11-20	caveolin 1	Homo sapiens	41-46
22914792-5	2012	Sterol and oxysterol enhance endothelial cav-1/eNOS interaction and suppress NO production, but these effects are reversed by apoE.	Oxysterols	11-20	apolipoprotein E	Homo sapiens	126-130
22999953-1	2012	7alpha,25-dihydroxycholesterol (7alpha,25-OHC) is a ligand for the G protein-coupled receptor EBI2; however, the cellular sources of this oxysterol are undefined.	Oxysterols	138-147	G protein-coupled receptor 183	Homo sapiens	94-98
22999953-7	2012	These findings establish that CYP7B1 and HSD3B7, as well as CH25H, have essential roles in controlling oxysterol production in lymphoid tissues, and they suggest that differential enzyme expression in stromal cell subsets establishes 7alpha,25-OHC gradients required for B cell responses.	Oxysterols	103-112	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	Homo sapiens	41-47
22999953-7	2012	These findings establish that CYP7B1 and HSD3B7, as well as CH25H, have essential roles in controlling oxysterol production in lymphoid tissues, and they suggest that differential enzyme expression in stromal cell subsets establishes 7alpha,25-OHC gradients required for B cell responses.	Oxysterols	103-112	cholesterol 25-hydroxylase	Homo sapiens	60-65
22617754-6	2012	This new study, in combination with important prior work, provides clues to several long-standing mysteries, such as how AKT might regulate lipid-lowering and glucose-lowering pathways that become insulin-resistant but also lipogenic pathways that remain insulin-responsive, as well as a potential role for NOX4 in insulin-stimulated generation of oxysterol ligands for LXR, a key lipogenic factor.	Oxysterols	348-357	AKT serine/threonine kinase 1	Homo sapiens	121-124
22683860-1	2012	ORP8 is an oxysterol/cholesterol binding protein anchored to the endoplasmic reticulum and the nuclear envelope, and is abundantly expressed in the macrophage.	Oxysterols	11-20	oxysterol binding protein-like 8	Mus musculus	0-4
22657538-4	2012	Using these drugs and oxysterols, we have determined which aspects of cholesterol homoeostasis should be targeted in prostate cancer, e.g. cellular cholesterol levels are increased by the transcription factor SREBP-2 (sterol-regulatory-element-binding protein isoform 2), whereas LXR (liver X receptor) promotes cholesterol efflux.	Oxysterols	22-32	sterol regulatory element binding transcription factor 2	Homo sapiens	209-216
22496390-10	2012	We find significant accumulation of three oxysterols, 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol, in mouse aortas of dyslipidemic ApoE-/- mice at the early stage of atherosclerosis.	Oxysterols	42-52	apolipoprotein E	Mus musculus	162-166
22238372-5	2012	Inhibition of TLR4 activation using selective inhibitors of TLR4 complex formation (OxPAPC) or signalling transmission (CLI095) prevented lipopolysaccharide (LPS)- and oxysterol-induced inflammatory cytokine production.	Oxysterols	168-177	toll like receptor 4	Homo sapiens	14-18
22238372-5	2012	Inhibition of TLR4 activation using selective inhibitors of TLR4 complex formation (OxPAPC) or signalling transmission (CLI095) prevented lipopolysaccharide (LPS)- and oxysterol-induced inflammatory cytokine production.	Oxysterols	168-177	toll like receptor 4	Homo sapiens	60-64
22238372-11	2012	Together, these findings indicate that although oxysterols likely activate both pro- and anti-inflammatory pathways in the placenta, the predominant effect is the promotion of placental inflammation via TLR4-dependent activation of NF-kappaB.	Oxysterols	48-58	toll like receptor 4	Homo sapiens	203-207
22238372-11	2012	Together, these findings indicate that although oxysterols likely activate both pro- and anti-inflammatory pathways in the placenta, the predominant effect is the promotion of placental inflammation via TLR4-dependent activation of NF-kappaB.	Oxysterols	48-58	nuclear factor kappa B subunit 1	Homo sapiens	232-241
22236548-0	2012	side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons.	Oxysterols	20-30	angiotensin I converting enzyme 2	Rattus norvegicus	42-46
22313893-4	2012	PI3K-, MEK1/2-, ERK1/2- and NF-kappaB-specific inhibitors were used to assess the specific role of the several players on the regulation of IL-8 production by oxysterols.	Oxysterols	159-169	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
22488423-5	2012	The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the scavenger receptor B type 1 mediate multiple intracellular signaling pathways as well as the efflux of cholesterol and/or oxysterols in response to apoA-I/HDL.	Oxysterols	191-201	ATP binding cassette subfamily A member 1	Homo sapiens	44-49
22488423-5	2012	The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the scavenger receptor B type 1 mediate multiple intracellular signaling pathways as well as the efflux of cholesterol and/or oxysterols in response to apoA-I/HDL.	Oxysterols	191-201	ATP binding cassette subfamily G member 1	Homo sapiens	54-59
22488423-5	2012	The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the scavenger receptor B type 1 mediate multiple intracellular signaling pathways as well as the efflux of cholesterol and/or oxysterols in response to apoA-I/HDL.	Oxysterols	191-201	apolipoprotein A1	Homo sapiens	217-223
22488423-7	2012	SUMMARY: Current data suggest that in endothelial cells ABCA1 and ABCG1 mediate the activation of intracellular signaling pathways primarily through the efflux of cholesterol and oxysterols to apoA-I/HDL.	Oxysterols	179-189	ATP binding cassette subfamily A member 1	Homo sapiens	56-61
22488423-7	2012	SUMMARY: Current data suggest that in endothelial cells ABCA1 and ABCG1 mediate the activation of intracellular signaling pathways primarily through the efflux of cholesterol and oxysterols to apoA-I/HDL.	Oxysterols	179-189	ATP binding cassette subfamily G member 1	Homo sapiens	66-71
23130136-8	2012	CONCLUSIONS: The oxysterol 24(S),25-EC prevented foam cell formation in human SMCs by attenuation of LDL receptor-mediated LDL uptake and stimulation of cholesterol efflux, restoring the elaboration of extracellular matrix.	Oxysterols	17-26	low density lipoprotein receptor	Homo sapiens	101-113
21983012-0	2012	Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol.	Oxysterols	146-155	DNA damage inducible transcript 3	Homo sapiens	37-41
21983012-0	2012	Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol.	Oxysterols	146-155	leptin	Homo sapiens	85-91
21258856-2	2012	We have previously demonstrated that adenosine A(2A) receptors inhibit foam cell formation and stimulate production of cholesterol 27-hydroxylase (CYP27A1), an enzyme involved in the conversion of cholesterol to oxysterols.	Oxysterols	212-222	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	147-154
22488423-7	2012	SUMMARY: Current data suggest that in endothelial cells ABCA1 and ABCG1 mediate the activation of intracellular signaling pathways primarily through the efflux of cholesterol and oxysterols to apoA-I/HDL.	Oxysterols	179-189	apolipoprotein A1	Homo sapiens	193-199
24970128-7	2012	The cytoplasmic oxysterol-binding protein (OSBP) homologues form a group of oxysterol/cholesterol sensors that has recently attracted a lot of attention.	Oxysterols	16-25	oxysterol binding protein	Homo sapiens	43-47
22785139-4	2012	Compared with HFD, oxysterol-HFD did not affect plasma lipid levels but did accelerate plaque destabilization and rupture, which was associated with increased monocyte infiltration/activation, monocyte chemoattractant protein-1 (MCP-1) expression, and matrix metalloproteinase (MMP) activity.	Oxysterols	19-28	chemokine (C-C motif) ligand 2	Mus musculus	193-227
22785139-4	2012	Compared with HFD, oxysterol-HFD did not affect plasma lipid levels but did accelerate plaque destabilization and rupture, which was associated with increased monocyte infiltration/activation, monocyte chemoattractant protein-1 (MCP-1) expression, and matrix metalloproteinase (MMP) activity.	Oxysterols	19-28	chemokine (C-C motif) ligand 2	Mus musculus	229-234
22785139-5	2012	Dietary oxysterol-induced plaque destabilization and rupture were blunted in ApoE(-/-) CCR2(-/-) mice.	Oxysterols	8-17	apolipoprotein E	Mus musculus	77-81
22785139-5	2012	Dietary oxysterol-induced plaque destabilization and rupture were blunted in ApoE(-/-) CCR2(-/-) mice.	Oxysterols	8-17	chemokine (C-C motif) receptor 2	Mus musculus	87-91
22785139-7	2012	These data indicate a primary role for monocyte-mediated inflammation via the MCP-1-CCR2 pathway and the resultant increase in MMP activity in plaque destabilization and rupture induced by dietary oxysterols in ApoE(-/-) mice.	Oxysterols	197-207	apolipoprotein E	Mus musculus	211-215
22236548-3	2012	ACE activity positively correlated with plasma and CSF 27-hydroxycholesterol (27-OH) levels, an oxysterol that passes to the brain from the blood.	Oxysterols	96-105	angiotensin I converting enzyme	Rattus norvegicus	0-3
22236548-7	2012	RESULTS: The levels of ACE2 and MasR were increased by a physiological concentration (1 muM) of these oxysterols after 24 h. CONCLUSIONS: 24S-OH and 27-OH enhance the brain RAS by acting on different levels, from the precursor to several downstream enzymes.	Oxysterols	102-112	angiotensin I converting enzyme 2	Rattus norvegicus	23-27
21912524-2	2011	Rudolph is an allele of the cholesterol biosynthetic enzyme, hydroxysteroid (17-beta) dehydrogenase 7, which is an intriguing finding given the recent implication of oxysterols in mediating intracellular Hedgehog (Hh) signaling.	Oxysterols	166-176	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	61-101
22095132-8	2011	Mutagenesis studies identify critical residues in the TM domains that are important for ABCG1 to alter sterol efflux, induce sterol regulatory element binding protein-2 (SREBP-2) processing, and selectively attenuate the oxysterol-mediated repression of SREBP-2 processing.	Oxysterols	221-230	ATP binding cassette subfamily G member 1	Homo sapiens	88-93
22095132-8	2011	Mutagenesis studies identify critical residues in the TM domains that are important for ABCG1 to alter sterol efflux, induce sterol regulatory element binding protein-2 (SREBP-2) processing, and selectively attenuate the oxysterol-mediated repression of SREBP-2 processing.	Oxysterols	221-230	sterol regulatory element binding transcription factor 2	Homo sapiens	125-168
22095132-8	2011	Mutagenesis studies identify critical residues in the TM domains that are important for ABCG1 to alter sterol efflux, induce sterol regulatory element binding protein-2 (SREBP-2) processing, and selectively attenuate the oxysterol-mediated repression of SREBP-2 processing.	Oxysterols	221-230	sterol regulatory element binding transcription factor 2	Homo sapiens	170-177
22095132-8	2011	Mutagenesis studies identify critical residues in the TM domains that are important for ABCG1 to alter sterol efflux, induce sterol regulatory element binding protein-2 (SREBP-2) processing, and selectively attenuate the oxysterol-mediated repression of SREBP-2 processing.	Oxysterols	221-230	sterol regulatory element binding transcription factor 2	Homo sapiens	254-261
21951066-0	2011	The oxysterol 27-hydroxycholesterol regulates alpha-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson"s disease.	Oxysterols	4-13	synuclein alpha	Homo sapiens	46-61
21951066-3	2011	We showed that the oxysterol 27-hydroxycholesterol (27-OHC) reduces the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, and increases alpha-synuclein levels in SH-SY5Y cells.	Oxysterols	19-28	synuclein alpha	Homo sapiens	175-190
21797280-0	2011	Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.	Oxysterols	26-36	sarcosine dehydrogenase	Homo sapiens	121-124
21757691-1	2011	ATP-binding cassette transporter A1 (ABCA1) mediates the rate-limiting step in high density lipoprotein (HDL) particle formation, and its expression is regulated primarily by oxysterol-dependent activation of liver X receptors.	Oxysterols	175-184	ATP binding cassette subfamily A member 1	Homo sapiens	0-35
21757691-1	2011	ATP-binding cassette transporter A1 (ABCA1) mediates the rate-limiting step in high density lipoprotein (HDL) particle formation, and its expression is regulated primarily by oxysterol-dependent activation of liver X receptors.	Oxysterols	175-184	ATP binding cassette subfamily A member 1	Homo sapiens	37-42
21514284-3	2011	Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.	Oxysterols	53-63	paraoxonase 1	Homo sapiens	262-275
21514284-3	2011	Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.	Oxysterols	53-62	paraoxonase 1	Homo sapiens	262-275
21875689-8	2011	High cholesterol (HC) diet-feeding, which is thought to provide oxysterols as the natural agonists, could also increase expression of CETP and other LXR target genes.	Oxysterols	64-74	nuclear receptor subfamily 1, group H, member 3	Mus musculus	149-152
21774076-4	2011	In addition, cyclopamine is able to modulate, along with oxysterols and other products, the ABCG2 transporter by increasing Ho342 and mitoxantrone uptake.	Oxysterols	57-67	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	92-97
21503957-5	2011	Treatment with oxysterols together with PPARgamma activator, troglitazone (Tro), inhibited mRNA expression for adipogenic genes PPARgamma, LPL, and aP2, and inhibited the formation of adipocytes.	Oxysterols	15-25	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	40-49
21664966-3	2011	In human promonocytic U937 cells, we investigated the effects of an oxysterol mixture of composition similar to that in advanced human carotid plaques on the expression and synthesis of MMP-9 and its endogenous inhibitors TIMP-1 and TIMP-2.	Oxysterols	68-77	matrix metallopeptidase 9	Homo sapiens	186-191
21664966-6	2011	Using antioxidants or specific inhibitors or siRNAs, we demonstrated that the oxysterol mixture induces MMP-9 expression through: (i) overproduction of reactive oxygen species, probably by NADPH-oxidase and mitochondria; (ii) up-regulation of mitogen-activated protein kinase signaling pathways via protein kinase C; and (iii) up-regulation of activator protein-1- and nuclear factor-kappaB-DNA binding.	Oxysterols	78-87	matrix metallopeptidase 9	Homo sapiens	104-109
21664966-7	2011	These results suggest, for the first time, that oxysterols accumulating in advanced atherosclerotic lesions significantly contribute to plaque vulnerability by promoting MMP-9/TIMP-1/2 imbalance in phagocytic cells.	Oxysterols	48-58	matrix metallopeptidase 9	Homo sapiens	170-175
21664966-7	2011	These results suggest, for the first time, that oxysterols accumulating in advanced atherosclerotic lesions significantly contribute to plaque vulnerability by promoting MMP-9/TIMP-1/2 imbalance in phagocytic cells.	Oxysterols	48-58	TIMP metallopeptidase inhibitor 1	Homo sapiens	176-182
21576599-4	2011	This oxysterol is also synthesized by sterol 27-hydroxylase (CYP27A1) and cholesterol 24-hydroxylase(CYP46A1), but it is only a minor product of these enzymes.	Oxysterols	5-14	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	38-59
21576599-4	2011	This oxysterol is also synthesized by sterol 27-hydroxylase (CYP27A1) and cholesterol 24-hydroxylase(CYP46A1), but it is only a minor product of these enzymes.	Oxysterols	5-14	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	61-68
21576599-4	2011	This oxysterol is also synthesized by sterol 27-hydroxylase (CYP27A1) and cholesterol 24-hydroxylase(CYP46A1), but it is only a minor product of these enzymes.	Oxysterols	5-14	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	101-108
21796211-5	2011	Here we isolate oxysterols from porcine spleen extracts and show that they are endogenous ligands for EBI2.	Oxysterols	16-26	G protein-coupled receptor 183	Mus musculus	102-106
21796212-4	2011	Functional activation of human EBI2 by 7alpha,25-OHC and closely related oxysterols was verified by monitoring second messenger readouts and saturable, high-affinity radioligand binding.	Oxysterols	73-83	G protein-coupled receptor 183	Homo sapiens	31-35
21796212-5	2011	Furthermore, we find that 7alpha,25-OHC and closely related oxysterols act as chemoattractants for immune cells expressing EBI2 by directing cell migration in vitro and in vivo.	Oxysterols	60-70	G protein-coupled receptor 183	Homo sapiens	123-127
21359969-0	2011	Lanthanum chloride suppresses oxysterol-induced ECV-304 cell apoptosis via inhibition of intracellular Ca(2+) concentration elevation, oxidative stress, and activation of ERK and NF-kappaB signaling pathways.	Oxysterols	30-39	mitogen-activated protein kinase 1	Homo sapiens	171-174
21359969-0	2011	Lanthanum chloride suppresses oxysterol-induced ECV-304 cell apoptosis via inhibition of intracellular Ca(2+) concentration elevation, oxidative stress, and activation of ERK and NF-kappaB signaling pathways.	Oxysterols	30-39	nuclear factor kappa B subunit 1	Homo sapiens	179-188
21334438-3	2011	In the last decade, the LXR natural ligands have been shown to be oxysterols, molecules derived from cholesterol.	Oxysterols	66-76	nuclear receptor subfamily 1, group H, member 2	Mus musculus	24-27
21628456-8	2011	Our results indicated that the SSD was required for sterol pathway signals to stimulate Hmg2 ER-associated degradation and was employed for detection of both geranylgeranyl pyrophosphate and a secondary oxysterol signal.	Oxysterols	203-212	high mobility group box 2	Homo sapiens	88-92
21715627-5	2011	We demonstrate that oxysterols inhibit peripheral myelin gene expression [myelin protein zero (MPZ) and peripheral myelin protein-22 (PMP22)] in a Schwann cell line.	Oxysterols	20-30	myelin protein zero	Mus musculus	95-98
21715627-5	2011	We demonstrate that oxysterols inhibit peripheral myelin gene expression [myelin protein zero (MPZ) and peripheral myelin protein-22 (PMP22)] in a Schwann cell line.	Oxysterols	20-30	peripheral myelin protein 22	Mus musculus	104-132
21715627-5	2011	We demonstrate that oxysterols inhibit peripheral myelin gene expression [myelin protein zero (MPZ) and peripheral myelin protein-22 (PMP22)] in a Schwann cell line.	Oxysterols	20-30	peripheral myelin protein 22	Mus musculus	134-139
21503957-5	2011	Treatment with oxysterols together with PPARgamma activator, troglitazone (Tro), inhibited mRNA expression for adipogenic genes PPARgamma, LPL, and aP2, and inhibited the formation of adipocytes.	Oxysterols	15-25	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	128-137
21503957-5	2011	Treatment with oxysterols together with PPARgamma activator, troglitazone (Tro), inhibited mRNA expression for adipogenic genes PPARgamma, LPL, and aP2, and inhibited the formation of adipocytes.	Oxysterols	15-25	lipoprotein lipase	Rattus norvegicus	139-142
21503957-5	2011	Treatment with oxysterols together with PPARgamma activator, troglitazone (Tro), inhibited mRNA expression for adipogenic genes PPARgamma, LPL, and aP2, and inhibited the formation of adipocytes.	Oxysterols	15-25	fatty acid binding protein 4	Rattus norvegicus	148-151
21411718-0	2011	Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells.	Oxysterols	35-44	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	72-79
21035514-2	2011	However, it is still unknown whether oxysterol-induced apoptosis in neuronal cells is mediated by Akt and NF-kappaB pathways.	Oxysterols	37-46	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
21412171-9	2011	In htau-ApoE mice on the high cholesterol regimen, brain oxysterol levels were less than in htau-ApoE mice, and the numbers of neurons with pathologically altered tau were similar to those in htau-ApoE mice on the high-cholesterol diet.	Oxysterols	57-66	apolipoprotein E	Mus musculus	8-12
20563825-4	2011	Glial HO-1 expression may also impact cell survival and neuroplasticity in AD by modulating brain sterol/oxysterol metabolism and the degradation of tau by the proteasome.	Oxysterols	105-114	heme oxygenase 1	Homo sapiens	6-10
20573495-9	2011	Such an effect was accompanied by an inhibition of oxysterol-induced ROS production, mitogen-activated protein kinase phosphorylation and NF-kappaB activation.	Oxysterols	51-60	nuclear factor kappa B subunit 1	Homo sapiens	138-147
20573495-10	2011	The inhibition of oxysterol-induced cytokine stimulation was also mimicked by the specific NF-kappaB inhibitor pyrrolidine dithiocarbamate.	Oxysterols	18-27	nuclear factor kappa B subunit 1	Homo sapiens	91-100
21388551-10	2011	Oxysterols can induce the production of inflammatory cytokines such as interleukin-8 and interleukin-1beta.	Oxysterols	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
21388551-10	2011	Oxysterols can induce the production of inflammatory cytokines such as interleukin-8 and interleukin-1beta.	Oxysterols	0-10	interleukin 1 beta	Homo sapiens	89-106
21295699-4	2011	We find that Sac1-mediated PI4P metabolism requires the oxysterol-binding homology (Osh) proteins.	Oxysterols	56-65	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	13-17
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	128-138
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	nuclear receptor subfamily 1 group I member 2	Homo sapiens	146-165
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	nuclear receptor subfamily 1 group I member 2	Homo sapiens	167-170
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	nuclear receptor subfamily 1 group I member 3	Homo sapiens	173-205
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	nuclear receptor subfamily 1 group I member 3	Homo sapiens	207-210
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	155-165
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	nuclear receptor subfamily 1 group H member 4	Homo sapiens	235-238
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	vitamin D receptor	Homo sapiens	244-262
21395540-3	2011	These metabolites (oxysterols, bile acids, vitamin D3) act as activators of a battery of nuclear receptors, in particular liver X receptor (LXR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), farnesoid X receptor (FXR) and vitamin D receptor (VDR).	Oxysterols	19-29	vitamin D receptor	Homo sapiens	264-267
20570635-0	2010	Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.	Oxysterols	88-97	ATP binding cassette subfamily A member 1	Homo sapiens	10-15
20149624-6	2010	Tocopherols down-regulated (P&lt;.05) up to half of the genes involved in the cholesterol synthesis pathway, together with CYP27A1, which is involved in oxysterol production.	Oxysterols	153-162	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	123-130
20149624-10	2010	This effect involves a down-regulation of genes involved in the cholesterol synthesis pathway, resulting in down-regulation of CYP27A1 which, in turn, diminishes oxysterol concentrations.	Oxysterols	162-171	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	127-134
20881054-8	2010	The presence of OSBP, CERT, and PI4KIIalpha in the TGN of oxysterol-stimulated cells suggests that OSBP couples sterol binding or transfer activity with regulation of PI4KIIalpha activity, leading to CERT recruitment to the TGN and increased SM synthesis.	Oxysterols	58-67	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	16-20
20881054-8	2010	The presence of OSBP, CERT, and PI4KIIalpha in the TGN of oxysterol-stimulated cells suggests that OSBP couples sterol binding or transfer activity with regulation of PI4KIIalpha activity, leading to CERT recruitment to the TGN and increased SM synthesis.	Oxysterols	58-67	ceramide transfer protein	Cricetulus griseus	22-26
20881054-8	2010	The presence of OSBP, CERT, and PI4KIIalpha in the TGN of oxysterol-stimulated cells suggests that OSBP couples sterol binding or transfer activity with regulation of PI4KIIalpha activity, leading to CERT recruitment to the TGN and increased SM synthesis.	Oxysterols	58-67	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	99-103
20881054-8	2010	The presence of OSBP, CERT, and PI4KIIalpha in the TGN of oxysterol-stimulated cells suggests that OSBP couples sterol binding or transfer activity with regulation of PI4KIIalpha activity, leading to CERT recruitment to the TGN and increased SM synthesis.	Oxysterols	58-67	ceramide transfer protein	Cricetulus griseus	200-204
20836858-12	2010	The deleterious effects of this oxysterol ranged from Abeta accumulation to oxidative cell damage.	Oxysterols	32-41	amyloid beta precursor protein	Homo sapiens	54-59
20923702-2	2010	This report concerns the strong proinflammatory action that a dietary oxysterol mixture and, to a lesser extent, an identical concentration of unoxidized cholesterol exert on CaCo-2 colonic epithelial cells by up-regulating both expression and synthesis of interleukin 8.	Oxysterols	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	257-270
20923702-5	2010	Importantly, NOX1 hyperactivation by the oxysterol mixture or cholesterol was fully prevented by CaCo-2 cell preincubation with epigallocatechin-3-gallate.	Oxysterols	41-50	NADPH oxidase 1	Homo sapiens	13-17
20827719-9	2010	CONCLUSION: We note that OATP1B1 transcriptional regulation is under dual nuclear receptor control through the oxysterol sensing LXRalpha and the bile acid sensor FXR.	Oxysterols	111-120	solute carrier organic anion transporter family member 1B1	Homo sapiens	25-32
20827719-9	2010	CONCLUSION: We note that OATP1B1 transcriptional regulation is under dual nuclear receptor control through the oxysterol sensing LXRalpha and the bile acid sensor FXR.	Oxysterols	111-120	nuclear receptor subfamily 1 group H member 3	Homo sapiens	129-137
20838002-4	2010	These functions are mediated by specific oxysterol sensors, including liver X receptors (LXR), Insigs, and members of the oxysterol binding protein (OSBP) and OSBP-related protein family.	Oxysterols	41-50	oxysterol binding protein	Homo sapiens	122-147
20838002-4	2010	These functions are mediated by specific oxysterol sensors, including liver X receptors (LXR), Insigs, and members of the oxysterol binding protein (OSBP) and OSBP-related protein family.	Oxysterols	41-50	oxysterol binding protein	Homo sapiens	149-153
20838002-4	2010	These functions are mediated by specific oxysterol sensors, including liver X receptors (LXR), Insigs, and members of the oxysterol binding protein (OSBP) and OSBP-related protein family.	Oxysterols	41-50	oxysterol binding protein	Homo sapiens	159-163
20570635-0	2010	Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.	Oxysterols	88-97	ATP binding cassette subfamily G member 1	Homo sapiens	20-25
20570635-7	2010	Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity.	Oxysterols	80-90	ATP binding cassette subfamily A member 1	Homo sapiens	30-35
20570635-7	2010	Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity.	Oxysterols	80-90	ATP binding cassette subfamily G member 1	Homo sapiens	39-44
20570635-7	2010	Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity.	Oxysterols	80-89	ATP binding cassette subfamily A member 1	Homo sapiens	30-35
20570635-7	2010	Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity.	Oxysterols	80-89	ATP binding cassette subfamily G member 1	Homo sapiens	39-44
20570635-8	2010	These results identify syncytial ABCA1 and ABCG1 as important, inducible cholesterol transporters which also prevent placental accumulation of cytotoxic oxysterols.	Oxysterols	153-163	ATP binding cassette subfamily A member 1	Homo sapiens	33-38
20570635-8	2010	These results identify syncytial ABCA1 and ABCG1 as important, inducible cholesterol transporters which also prevent placental accumulation of cytotoxic oxysterols.	Oxysterols	153-163	ATP binding cassette subfamily G member 1	Homo sapiens	43-48
20395595-0	2010	Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.	Oxysterols	74-83	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-48
20466046-5	2010	Specific inhibitors confirmed that MMPs, EGFR and PI3K are involved in oxysterol-induced SMC migration, while EGFR, ERK, Akt, and sphingomyelin/ceramide pathways might play a role in SMC proliferation.	Oxysterols	71-80	matrix metallopeptidase 2	Homo sapiens	35-39
20466046-5	2010	Specific inhibitors confirmed that MMPs, EGFR and PI3K are involved in oxysterol-induced SMC migration, while EGFR, ERK, Akt, and sphingomyelin/ceramide pathways might play a role in SMC proliferation.	Oxysterols	71-80	epidermal growth factor receptor	Homo sapiens	41-45
20635334-3	2010	Patched 1 regulates the activity of Smoothened (1) via Vitamin D3, which inhibits Smoothened in the absence of hedgehog ligand or (2) via oxysterols, which activate Smoothened in the presence of hedgehog ligand.	Oxysterols	138-148	smoothened	Drosophila melanogaster	36-46
20211758-3	2010	We recently found that certain oxysterols, namely the 7-substituted oxysterols, bound to the ligand binding domains (LBDs) of RORalpha and RORgamma with high affinity, altered the LBD conformation and reduced coactivator binding resulting in suppression of the constitutive transcriptional activity of these two receptors.	Oxysterols	31-41	RAR related orphan receptor A	Homo sapiens	126-134
20211758-4	2010	Here, we show that another oxysterol, 24S-hydroxycholesterol (24S-OHC), is also a high affinity ligand for RORalpha and RORgamma (K(i) approximately 25 nM).	Oxysterols	27-36	RAR related orphan receptor A	Homo sapiens	107-128
20395595-0	2010	Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.	Oxysterols	74-83	ATP binding cassette subfamily G member 1	Homo sapiens	59-64
19937729-4	2010	The aim of this study was to examine the molecular basis of the biological effects of oxysterols on liver-derived cells, HepG2 and Huh7.	Oxysterols	86-96	MIR7-3 host gene	Homo sapiens	131-135
20673203-3	2010	Oxysterol sensors LXRs, oxysterol and cholesterol sensors INSIG and SCAP acting through controlled transcription factors SREBP, as well as sensors for oxidized fatty acids and their derivatives, PPAR, are the best studied.	Oxysterols	0-9	peroxisome proliferator activated receptor alpha	Homo sapiens	195-199
20045741-0	2010	Low-density lipoprotein and oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase in vitro.	Oxysterols	28-38	phosphate cytidylyltransferase 2, ethanolamine	Mus musculus	69-114
20044803-3	2010	In physiological conditions, high intracellular cholesterol levels cause increased synthesis of oxysterols, which activate LXR, thus triggering a transcriptional response for cholesterol secretion and catabolism.	Oxysterols	96-106	nuclear receptor subfamily 1, group H, member 3	Mus musculus	123-126
20044803-7	2010	The inactivation of LXR following PH is related to the reduced oxysterol availability by way of decreased synthesis, and increased sulfation and secretion.	Oxysterols	63-72	nuclear receptor subfamily 1, group H, member 3	Mus musculus	20-23
20138879-3	2010	25-hydroxycholesterol, a representative LXR activating oxysterol, suppressed IL-6 production and degranulation response in BMMCs following engagement of high-affinity IgE receptor (FcepsilonRI).	Oxysterols	55-64	nuclear receptor subfamily 1, group H, member 2	Mus musculus	40-43
20138879-3	2010	25-hydroxycholesterol, a representative LXR activating oxysterol, suppressed IL-6 production and degranulation response in BMMCs following engagement of high-affinity IgE receptor (FcepsilonRI).	Oxysterols	55-64	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	181-192
20333725-0	2010	Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cells.	Oxysterols	61-71	CD68 molecule	Homo sapiens	106-110
18597895-2	2010	Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation.	Oxysterols	69-79	heme oxygenase 1	Homo sapiens	0-16
18597895-2	2010	Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation.	Oxysterols	69-79	heme oxygenase 1	Homo sapiens	18-22
18597895-2	2010	Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation.	Oxysterols	69-79	nuclear receptor subfamily 1 group H member 3	Homo sapiens	187-195
18597895-2	2010	Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation.	Oxysterols	69-78	heme oxygenase 1	Homo sapiens	0-16
18597895-2	2010	Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation.	Oxysterols	69-78	heme oxygenase 1	Homo sapiens	18-22
19937729-6	2010	FACS investigations, caspase-3 activation, and Sytox Green immunofluorescent assay showed that pathological concentrations of oxysterols induced necrosis (30-50%) after 48 h of treatment.	Oxysterols	126-136	caspase 3	Homo sapiens	21-30
19761868-0	2010	Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.	Oxysterols	114-124	carboxylesterase 1	Homo sapiens	14-30
19761868-0	2010	Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.	Oxysterols	114-124	GLI family zinc finger 2	Homo sapiens	43-47
19761868-5	2010	Here, we report the direct inhibitory effects of several endogenous oxysterols and fatty acids on the CE activity of THP1 monocytes/macrophages and recombinant human CES1 and CES2.	Oxysterols	68-78	GLI family zinc finger 2	Homo sapiens	117-121
19761868-0	2010	Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.	Oxysterols	114-124	carboxylesterase 1	Homo sapiens	92-110
19761868-5	2010	Here, we report the direct inhibitory effects of several endogenous oxysterols and fatty acids on the CE activity of THP1 monocytes/macrophages and recombinant human CES1 and CES2.	Oxysterols	68-78	carboxylesterase 1	Homo sapiens	166-170
19654569-4	2010	The major exportable form of brain cholesterol is 24S-hydroxycholesterol, an oxysterol generated by the neuronal cholesterol 24-hydroxylase encoded by the CYP46A1 gene.	Oxysterols	77-86	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	113-139
19761868-5	2010	Here, we report the direct inhibitory effects of several endogenous oxysterols and fatty acids on the CE activity of THP1 monocytes/macrophages and recombinant human CES1 and CES2.	Oxysterols	68-78	carboxylesterase 2	Homo sapiens	175-179
19761868-12	2010	In addition, oxysterol-mediated inhibition of CES1 activity was demonstrated by pretreatment of human liver homogenates or intact THP1 cells with exogenous 27-HC, which resulted in significantly reduced hydrolysis of the pyrethroid insecticide bioresmethrin, a CES1-specific xenobiotic substrate.	Oxysterols	13-22	carboxylesterase 1	Homo sapiens	46-50
19761868-12	2010	In addition, oxysterol-mediated inhibition of CES1 activity was demonstrated by pretreatment of human liver homogenates or intact THP1 cells with exogenous 27-HC, which resulted in significantly reduced hydrolysis of the pyrethroid insecticide bioresmethrin, a CES1-specific xenobiotic substrate.	Oxysterols	13-22	GLI family zinc finger 2	Homo sapiens	130-134
19761868-12	2010	In addition, oxysterol-mediated inhibition of CES1 activity was demonstrated by pretreatment of human liver homogenates or intact THP1 cells with exogenous 27-HC, which resulted in significantly reduced hydrolysis of the pyrethroid insecticide bioresmethrin, a CES1-specific xenobiotic substrate.	Oxysterols	13-22	carboxylesterase 1	Homo sapiens	261-265
19157829-4	2010	Moreover, the carotenoid strongly prevented the increase of NOX-4, hsp70 and hsp90 expressions as well as the phosphorylation of the redox-sensitive p38, JNK and ERK1/2 induced by the oxysterol.	Oxysterols	184-193	NADPH oxidase 4	Homo sapiens	60-65
19157829-4	2010	Moreover, the carotenoid strongly prevented the increase of NOX-4, hsp70 and hsp90 expressions as well as the phosphorylation of the redox-sensitive p38, JNK and ERK1/2 induced by the oxysterol.	Oxysterols	184-193	heat shock protein family A (Hsp70) member 4	Homo sapiens	67-72
19157829-4	2010	Moreover, the carotenoid strongly prevented the increase of NOX-4, hsp70 and hsp90 expressions as well as the phosphorylation of the redox-sensitive p38, JNK and ERK1/2 induced by the oxysterol.	Oxysterols	184-193	heat shock protein 90 alpha family class A member 1	Homo sapiens	77-82
19157829-4	2010	Moreover, the carotenoid strongly prevented the increase of NOX-4, hsp70 and hsp90 expressions as well as the phosphorylation of the redox-sensitive p38, JNK and ERK1/2 induced by the oxysterol.	Oxysterols	184-193	mitogen-activated protein kinase 1	Homo sapiens	149-152
19157829-4	2010	Moreover, the carotenoid strongly prevented the increase of NOX-4, hsp70 and hsp90 expressions as well as the phosphorylation of the redox-sensitive p38, JNK and ERK1/2 induced by the oxysterol.	Oxysterols	184-193	mitogen-activated protein kinase 8	Homo sapiens	154-157
19157829-4	2010	Moreover, the carotenoid strongly prevented the increase of NOX-4, hsp70 and hsp90 expressions as well as the phosphorylation of the redox-sensitive p38, JNK and ERK1/2 induced by the oxysterol.	Oxysterols	184-193	mitogen-activated protein kinase 3	Homo sapiens	162-168
19654569-4	2010	The major exportable form of brain cholesterol is 24S-hydroxycholesterol, an oxysterol generated by the neuronal cholesterol 24-hydroxylase encoded by the CYP46A1 gene.	Oxysterols	77-86	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	155-162
19687010-1	2009	The CYP7B1 cytochrome P450 enzyme hydroxylates carbons 6 and 7 of the B ring of oxysterols and steroids.	Oxysterols	80-90	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	4-10
19895785-0	2009	ABCG1 mediated oxidized LDL-derived oxysterol efflux from macrophages.	Oxysterols	36-45	ATP binding cassette subfamily G member 1	Homo sapiens	0-5
19895785-11	2009	CONCLUSIONS: ABCG1 mediates oxysterol efflux from oxLDL-loaded macrophages, and the exported oxysterol by ABCG1 pathway can be selectively taken up by hepatocytes.	Oxysterols	28-37	ATP binding cassette subfamily G member 1	Homo sapiens	13-18
19687010-4	2009	Hepatic CYP7B1 activity is crucial for the inactivation of oxysterols and their subsequent conversion into bile salts.	Oxysterols	59-69	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-14
19811731-0	2009	[The apoptosis of mouse macrophage J774A.1 induced by oxysterol depend on NF-kappaB activation].	Oxysterols	54-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	74-83
19250336-6	2009	Interestingly, sPLA2 type IIA (sPLA2-IIA) over-expression partially rescued 158N cells from oxysterol-induced apoptosis.	Oxysterols	92-101	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	15-20
19522732-3	2009	We recently determined that HO-1 over-expression suppresses total CH levels by augmenting liver X receptor-mediated CH efflux and enhances oxysterol formation in cultured astroglia.	Oxysterols	139-148	heme oxygenase 1	Homo sapiens	28-32
19522732-6	2009	The relationships of sterol/oxysterol levels to HO-1 protein expression and clinical/demographic variables were determined by multivariable regression and non-parametric statistical analyses.	Oxysterols	28-37	heme oxygenase 1	Homo sapiens	48-52
19464253-1	2009	Akt plays a role in protecting macrophages from apoptosis induced by some oxysterols.	Oxysterols	74-84	thymoma viral proto-oncogene 1	Mus musculus	0-3
19464253-5	2009	Modification of Akt by the addition of a Gly-Ala repeat (GAr), a domain known to block ubiquitin-dependent targeting of proteins to the proteasome, resulted in a chimeric protein that is resistant to turn-over induced by 25-OH or 7-KC and provides protection from apoptosis induced by these oxysterols.	Oxysterols	291-301	thymoma viral proto-oncogene 1	Mus musculus	16-19
19464253-6	2009	These results uncover a new aspect of oxysterol regulation of Akt in macrophages; oxysterol-stimulated poly-ubiquitination of Akt and degradation by the proteasomal pathway.	Oxysterols	38-47	thymoma viral proto-oncogene 1	Mus musculus	62-65
19464253-6	2009	These results uncover a new aspect of oxysterol regulation of Akt in macrophages; oxysterol-stimulated poly-ubiquitination of Akt and degradation by the proteasomal pathway.	Oxysterols	38-47	thymoma viral proto-oncogene 1	Mus musculus	126-129
19464253-6	2009	These results uncover a new aspect of oxysterol regulation of Akt in macrophages; oxysterol-stimulated poly-ubiquitination of Akt and degradation by the proteasomal pathway.	Oxysterols	82-91	thymoma viral proto-oncogene 1	Mus musculus	62-65
19464253-6	2009	These results uncover a new aspect of oxysterol regulation of Akt in macrophages; oxysterol-stimulated poly-ubiquitination of Akt and degradation by the proteasomal pathway.	Oxysterols	82-91	thymoma viral proto-oncogene 1	Mus musculus	126-129
19373502-1	2009	Cholesterol metabolism as initiated by mitochondrial sterol 27-hydroxylase (CYP27A1) is a ubiquitous pathway capable of synthesizing multiple key regulatory oxysterols involved in lipid homeostasis.	Oxysterols	157-167	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	53-74
19373502-1	2009	Cholesterol metabolism as initiated by mitochondrial sterol 27-hydroxylase (CYP27A1) is a ubiquitous pathway capable of synthesizing multiple key regulatory oxysterols involved in lipid homeostasis.	Oxysterols	157-167	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	76-83
26124677-1	2009	The gene for Rhotekin 2 (RTKN2) was originally identified in a promyelocytic cell line resistant to oxysterol-induced apoptosis.	Oxysterols	100-109	rhotekin 2	Homo sapiens	13-23
26124677-1	2009	The gene for Rhotekin 2 (RTKN2) was originally identified in a promyelocytic cell line resistant to oxysterol-induced apoptosis.	Oxysterols	100-109	rhotekin 2	Homo sapiens	25-30
19553242-6	2009	In fibroblasts from affected subjects, oxysterol stimulation resulted in increased ABCA1 protein expression and normalized their defective phospholipid efflux defect.	Oxysterols	39-48	ATP binding cassette subfamily A member 1	Homo sapiens	83-88
19553242-9	2009	The defect in phospholipid efflux is due to defective ABCA1 protein regulation and can be corrected by treatment with physiological oxysterols, a current therapeutic target of interest, that may, with further studies, be used to raise HDL levels in patients with severe HDL deficiencies.	Oxysterols	132-142	ATP binding cassette subfamily A member 1	Homo sapiens	54-59
20187291-7	2009	OxLDL-induced TRPC1 translocation was dependent on actin cytoskeleton and associated with a dramatic rise of 7-ketocholesterol (a major oxysterol in oxLDL) into caveolar membranes, whereas the caveolar content of cholesterol was unchanged.	Oxysterols	136-145	transient receptor potential cation channel subfamily C member 1	Homo sapiens	14-19
18945429-8	2009	These results suggest that StAR delivers cholesterol to mitochondria where regulatory oxysterols are generated.	Oxysterols	86-96	steroidogenic acute regulatory protein	Homo sapiens	27-31
19250336-6	2009	Interestingly, sPLA2 type IIA (sPLA2-IIA) over-expression partially rescued 158N cells from oxysterol-induced apoptosis.	Oxysterols	92-101	ATPase, class II, type 9A	Mus musculus	26-29
19250336-6	2009	Interestingly, sPLA2 type IIA (sPLA2-IIA) over-expression partially rescued 158N cells from oxysterol-induced apoptosis.	Oxysterols	92-101	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	31-40
19250336-9	2009	Short interfering RNA strategy allowed to establish that stimulation of sPLA2-IIA is mediated by pregnane X receptor (PXR) at high oxysterol concentration (10 microM) and by LXR beta at basal oxysterol concentration.	Oxysterols	131-140	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	72-81
19250336-9	2009	Short interfering RNA strategy allowed to establish that stimulation of sPLA2-IIA is mediated by pregnane X receptor (PXR) at high oxysterol concentration (10 microM) and by LXR beta at basal oxysterol concentration.	Oxysterols	131-140	nuclear receptor subfamily 1, group I, member 2	Mus musculus	97-116
19250336-9	2009	Short interfering RNA strategy allowed to establish that stimulation of sPLA2-IIA is mediated by pregnane X receptor (PXR) at high oxysterol concentration (10 microM) and by LXR beta at basal oxysterol concentration.	Oxysterols	131-140	nuclear receptor subfamily 1, group I, member 2	Mus musculus	118-121
19250336-9	2009	Short interfering RNA strategy allowed to establish that stimulation of sPLA2-IIA is mediated by pregnane X receptor (PXR) at high oxysterol concentration (10 microM) and by LXR beta at basal oxysterol concentration.	Oxysterols	192-201	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	72-81
19250336-9	2009	Short interfering RNA strategy allowed to establish that stimulation of sPLA2-IIA is mediated by pregnane X receptor (PXR) at high oxysterol concentration (10 microM) and by LXR beta at basal oxysterol concentration.	Oxysterols	192-201	nuclear receptor subfamily 1, group H, member 2	Mus musculus	174-182
18317936-2	2009	An oxysterol-induced interleukin-8 (IL-8) secretion in human monocytes/macrophages has been previously noticed, but the mechanisms remained unclear.	Oxysterols	3-12	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
19338772-5	2009	As oxysterol-induced macrophage apoptosis requires acyl-coenzymeA:cholesterol acyltransferase (ACAT) activity, we tested their affects on ACAT activity.	Oxysterols	3-12	carboxylesterase 1G	Mus musculus	51-93
19338772-5	2009	As oxysterol-induced macrophage apoptosis requires acyl-coenzymeA:cholesterol acyltransferase (ACAT) activity, we tested their affects on ACAT activity.	Oxysterols	3-12	carboxylesterase 1G	Mus musculus	95-99
19338772-5	2009	As oxysterol-induced macrophage apoptosis requires acyl-coenzymeA:cholesterol acyltransferase (ACAT) activity, we tested their affects on ACAT activity.	Oxysterols	3-12	carboxylesterase 1G	Mus musculus	138-142
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	mitogen-activated protein kinase kinase 7	Homo sapiens	112-115
18317936-2	2009	An oxysterol-induced interleukin-8 (IL-8) secretion in human monocytes/macrophages has been previously noticed, but the mechanisms remained unclear.	Oxysterols	3-12	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	mitogen-activated protein kinase 3	Homo sapiens	116-122
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	174-178
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-185
18317936-3	2009	In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line.	Oxysterols	175-184	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18317936-3	2009	In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line.	Oxysterols	220-229	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Oxysterols	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Oxysterols	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Oxysterols	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
18317936-5	2009	Fluo-3 staining used in flow cytometry and video microscopy revealed an oxysterol-induced Ca(2+) influx, varying according to the oxysterol studied, leading to the activation of the MEK/ERK1/2 pathway as demonstrated by Western blot analysis.	Oxysterols	72-81	mitogen-activated protein kinase kinase 7	Homo sapiens	182-185
18317936-5	2009	Fluo-3 staining used in flow cytometry and video microscopy revealed an oxysterol-induced Ca(2+) influx, varying according to the oxysterol studied, leading to the activation of the MEK/ERK1/2 pathway as demonstrated by Western blot analysis.	Oxysterols	72-81	mitogen-activated protein kinase 3	Homo sapiens	186-192
18317936-5	2009	Fluo-3 staining used in flow cytometry and video microscopy revealed an oxysterol-induced Ca(2+) influx, varying according to the oxysterol studied, leading to the activation of the MEK/ERK1/2 pathway as demonstrated by Western blot analysis.	Oxysterols	130-139	mitogen-activated protein kinase kinase 7	Homo sapiens	182-185
18317936-5	2009	Fluo-3 staining used in flow cytometry and video microscopy revealed an oxysterol-induced Ca(2+) influx, varying according to the oxysterol studied, leading to the activation of the MEK/ERK1/2 pathway as demonstrated by Western blot analysis.	Oxysterols	130-139	mitogen-activated protein kinase 3	Homo sapiens	186-192
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
19136384-10	2009	In hepatic stellate cells, oxysterols increased IL-8 secretion through a NF-kappaB-independent mechanism and upregulated TIMP-1 expression.	Oxysterols	27-37	chemokine (C-X-C motif) ligand 15	Mus musculus	48-52
20126301-7	2009	We also suggest the potential for two p53 target genes, START domain-containing protein 4 (StARD4) and oxysterol-binding protein (OSBP), with the concomitant synthesis of the signaling molecule oxysterol, to participate in adipogenesis.	Oxysterols	103-112	tumor protein p53	Homo sapiens	38-41
20126301-7	2009	We also suggest the potential for two p53 target genes, START domain-containing protein 4 (StARD4) and oxysterol-binding protein (OSBP), with the concomitant synthesis of the signaling molecule oxysterol, to participate in adipogenesis.	Oxysterols	103-112	oxysterol binding protein	Homo sapiens	130-134
18997165-13	2009	Activation of LXR by either endogenous oxysterols or synthetic agonists induces the expression of many genes, including those encoding ATP-binding cassette (ABC) transporters ABCA1, ABCG1, ABCG5, and ABCG8.	Oxysterols	39-49	ATP binding cassette subfamily A member 1	Homo sapiens	175-180
18997165-13	2009	Activation of LXR by either endogenous oxysterols or synthetic agonists induces the expression of many genes, including those encoding ATP-binding cassette (ABC) transporters ABCA1, ABCG1, ABCG5, and ABCG8.	Oxysterols	39-49	ATP binding cassette subfamily G member 1	Homo sapiens	182-187
18997165-13	2009	Activation of LXR by either endogenous oxysterols or synthetic agonists induces the expression of many genes, including those encoding ATP-binding cassette (ABC) transporters ABCA1, ABCG1, ABCG5, and ABCG8.	Oxysterols	39-49	ATP binding cassette subfamily G member 5	Homo sapiens	189-194
18997165-13	2009	Activation of LXR by either endogenous oxysterols or synthetic agonists induces the expression of many genes, including those encoding ATP-binding cassette (ABC) transporters ABCA1, ABCG1, ABCG5, and ABCG8.	Oxysterols	39-49	ATP binding cassette subfamily G member 8	Homo sapiens	200-205
19013211-1	2009	Two members of the human aldo-keto reductase (AKR) superfamily participate in the biosynthesis of bile acids by catalyzing the NADP(H) dependent reduction of 3-keto groups (AKR1C4) and Delta4 double bonds (AKR1D1) of oxysterol precursors.	Oxysterols	217-226	aldo-keto reductase family 1 member C4	Homo sapiens	173-179
19013211-1	2009	Two members of the human aldo-keto reductase (AKR) superfamily participate in the biosynthesis of bile acids by catalyzing the NADP(H) dependent reduction of 3-keto groups (AKR1C4) and Delta4 double bonds (AKR1D1) of oxysterol precursors.	Oxysterols	217-226	aldo-keto reductase family 1 member D1	Homo sapiens	206-212
19136384-10	2009	In hepatic stellate cells, oxysterols increased IL-8 secretion through a NF-kappaB-independent mechanism and upregulated TIMP-1 expression.	Oxysterols	27-37	tissue inhibitor of metalloproteinase 1	Mus musculus	121-127
18996837-1	2009	Side chain oxysterols exert cholesterol homeostatic effects by suppression of sterol regulatory element-binding protein maturation and promoting degradation of hydroxymethylglutaryl-CoA reductase.	Oxysterols	11-21	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	78-119
18980580-0	2009	Oxysterol activation of phosphatidylcholine synthesis involves CTP:phosphocholine cytidylyltransferase alpha translocation to the nuclear envelope.	Oxysterols	0-9	choline-phosphate cytidylyltransferase A	Cricetulus griseus	63-108
18996837-1	2009	Side chain oxysterols exert cholesterol homeostatic effects by suppression of sterol regulatory element-binding protein maturation and promoting degradation of hydroxymethylglutaryl-CoA reductase.	Oxysterols	11-21	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	160-195
19046352-3	2009	In the current study, we determined the effects of HO-1 over-expression and its byproducts iron (Fe(2+)), carbon monoxide (CO) and bilirubin on CH biosynthesis, CH efflux and oxysterol formation in cultured astroglia.	Oxysterols	175-184	heme oxygenase 1	Homo sapiens	51-55
18495460-4	2009	This oxysterol also induces important changes in lipid content and/or organization of the cytoplasmic membrane demonstrated with merocyanine 540 and fluorescence anisotropy, a loss of PI3-K activity and dephosphorylation of PDK-1 and Akt.	Oxysterols	5-14	pyruvate dehydrogenase kinase 1	Homo sapiens	224-229
18495460-4	2009	This oxysterol also induces important changes in lipid content and/or organization of the cytoplasmic membrane demonstrated with merocyanine 540 and fluorescence anisotropy, a loss of PI3-K activity and dephosphorylation of PDK-1 and Akt.	Oxysterols	5-14	AKT serine/threonine kinase 1	Homo sapiens	234-237
18815215-1	2008	The nuclear hormone receptors liver X receptor alpha (LXRalpha) and LXRbeta function as physiological receptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol and lipid metabolism.	Oxysterols	150-160	nuclear receptor subfamily 1 group H member 3	Homo sapiens	54-62
18515973-7	2009	Instead, this oxysterol slowed degradation of IL-6 mRNA and increased the amount of cytoplasmic HuR.	Oxysterols	14-23	interleukin 6	Homo sapiens	46-50
18815215-1	2008	The nuclear hormone receptors liver X receptor alpha (LXRalpha) and LXRbeta function as physiological receptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol and lipid metabolism.	Oxysterols	150-160	nuclear receptor subfamily 1 group H member 3	Homo sapiens	68-75
18713821-7	2008	RESULTS: Serum oxysterol concentrations in the adolescent cohort correlated positively with insulin (P&lt;0.05), total cholesterol (P&lt;0.05), non-high-density lipoprotein cholesterol (P&lt;0.05), low-density lipoprotein cholesterol (P&lt;0.05), and ApoB (P&lt;0.01).	Oxysterols	15-24	apolipoprotein B	Homo sapiens	251-255
18713821-8	2008	ApoB and fasting insulin were found to be the major determinants of serum oxysterols after adjustment for body mass index.	Oxysterols	74-84	apolipoprotein B	Homo sapiens	0-4
18713821-10	2008	CONCLUSION: Serum oxysterol concentrations increase with obesity, insulin, and ApoB, which are established derangements associated with the metabolic syndrome.	Oxysterols	18-27	apolipoprotein B	Homo sapiens	79-83
18782758-3	2008	The transcription of ABCA1 is regulated by intracellular oxysterol concentration via the nuclear liver X receptor (LXR)/retinoid X receptor (RXR); once synthesized, ABCA1 protein turns over rapidly with a half-life of 1-2 h. Here, we show that the LXRbeta/RXR complex binds directly to ABCA1 on the plasma membrane of macrophages and modulates cholesterol secretion.	Oxysterols	57-66	ATP binding cassette subfamily A member 1	Homo sapiens	21-26
18924609-3	2008	Whether the beneficial effects of HDL on ECs depend on its involvement in cholesterol efflux via the ATP-binding cassette transporters ABCA1 and ABCG1, which promote efflux of cholesterol and oxysterols from macrophages, has not been investigated.	Oxysterols	192-202	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	135-140
18924609-3	2008	Whether the beneficial effects of HDL on ECs depend on its involvement in cholesterol efflux via the ATP-binding cassette transporters ABCA1 and ABCG1, which promote efflux of cholesterol and oxysterols from macrophages, has not been investigated.	Oxysterols	192-202	ATP binding cassette subfamily G member 1	Mus musculus	145-150
18502209-6	2008	Some (oxy)sterols can accelerate the degradation of the key cholesterol biosynthetic enzyme, HMG-CoA reductase, and/or serve as natural ligand activators of a nuclear receptor (LXR) involved in coordinating many aspects of reverse cholesterol transport.	Oxysterols	5-17	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	93-110
18782758-3	2008	The transcription of ABCA1 is regulated by intracellular oxysterol concentration via the nuclear liver X receptor (LXR)/retinoid X receptor (RXR); once synthesized, ABCA1 protein turns over rapidly with a half-life of 1-2 h. Here, we show that the LXRbeta/RXR complex binds directly to ABCA1 on the plasma membrane of macrophages and modulates cholesterol secretion.	Oxysterols	57-66	retinoid X receptor alpha	Homo sapiens	120-139
18782758-3	2008	The transcription of ABCA1 is regulated by intracellular oxysterol concentration via the nuclear liver X receptor (LXR)/retinoid X receptor (RXR); once synthesized, ABCA1 protein turns over rapidly with a half-life of 1-2 h. Here, we show that the LXRbeta/RXR complex binds directly to ABCA1 on the plasma membrane of macrophages and modulates cholesterol secretion.	Oxysterols	57-66	retinoid X receptor alpha	Homo sapiens	141-144
18782758-3	2008	The transcription of ABCA1 is regulated by intracellular oxysterol concentration via the nuclear liver X receptor (LXR)/retinoid X receptor (RXR); once synthesized, ABCA1 protein turns over rapidly with a half-life of 1-2 h. Here, we show that the LXRbeta/RXR complex binds directly to ABCA1 on the plasma membrane of macrophages and modulates cholesterol secretion.	Oxysterols	57-66	ATP binding cassette subfamily A member 1	Homo sapiens	165-170
18782758-3	2008	The transcription of ABCA1 is regulated by intracellular oxysterol concentration via the nuclear liver X receptor (LXR)/retinoid X receptor (RXR); once synthesized, ABCA1 protein turns over rapidly with a half-life of 1-2 h. Here, we show that the LXRbeta/RXR complex binds directly to ABCA1 on the plasma membrane of macrophages and modulates cholesterol secretion.	Oxysterols	57-66	nuclear receptor subfamily 1 group H member 2	Homo sapiens	248-255
18782758-3	2008	The transcription of ABCA1 is regulated by intracellular oxysterol concentration via the nuclear liver X receptor (LXR)/retinoid X receptor (RXR); once synthesized, ABCA1 protein turns over rapidly with a half-life of 1-2 h. Here, we show that the LXRbeta/RXR complex binds directly to ABCA1 on the plasma membrane of macrophages and modulates cholesterol secretion.	Oxysterols	57-66	retinoid X receptor alpha	Homo sapiens	256-259
18782758-3	2008	The transcription of ABCA1 is regulated by intracellular oxysterol concentration via the nuclear liver X receptor (LXR)/retinoid X receptor (RXR); once synthesized, ABCA1 protein turns over rapidly with a half-life of 1-2 h. Here, we show that the LXRbeta/RXR complex binds directly to ABCA1 on the plasma membrane of macrophages and modulates cholesterol secretion.	Oxysterols	57-66	ATP binding cassette subfamily A member 1	Homo sapiens	165-170
18782758-5	2008	When cholesterol accumulates, oxysterols bind to LXRbeta, and the LXRbeta/RXR complex dissociates from ABCA1, restoring ABCA1 activity and allowing apoA-I-dependent cholesterol secretion.	Oxysterols	30-40	nuclear receptor subfamily 1 group H member 2	Homo sapiens	49-56
18613030-0	2008	Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling.	Oxysterols	0-9	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	85-90
18613030-5	2008	In addition to activating the hedgehog signaling pathway, oxysterol-induced osteogenic differentiation is mediated through a Wnt signaling-related, Dkk-1-inhibitable mechanism.	Oxysterols	58-67	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	148-153
18613030-7	2008	These oxysterol effects, which occurred in the absence of beta-catenin accumulation or TCF/Lef activation, were inhibited by the hedgehog pathway inhibitor, cyclopamine, and/or by the Wnt pathway inhibitor, Dkk-1.	Oxysterols	6-15	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	207-212
18613030-9	2008	Finally, activators of canonical Wnt signaling, Wnt3a and Wnt1, inhibited spontaneous, oxysterol-, and Shh-induced osteogenic differentiation of bone marrow stromal cells, suggesting the involvement of a non-canonical Wnt pathway in pro-osteogenic differentiation events.	Oxysterols	87-96	Wnt family member 3A	Homo sapiens	48-53
18613030-9	2008	Finally, activators of canonical Wnt signaling, Wnt3a and Wnt1, inhibited spontaneous, oxysterol-, and Shh-induced osteogenic differentiation of bone marrow stromal cells, suggesting the involvement of a non-canonical Wnt pathway in pro-osteogenic differentiation events.	Oxysterols	87-96	Wnt family member 1	Homo sapiens	58-62
18722677-3	2008	In support of this hypothesis is the recent demonstration that the oxysterol 27-hydroxycholesterol (27HC) interacts with and modulates the transcriptional activity of both estrogen receptor (ER) subtypes and that the relative agonist and antagonist activity of 27HC is influenced by both cell and promoter context.	Oxysterols	67-76	estrogen receptor 1	Homo sapiens	172-189
18722677-3	2008	In support of this hypothesis is the recent demonstration that the oxysterol 27-hydroxycholesterol (27HC) interacts with and modulates the transcriptional activity of both estrogen receptor (ER) subtypes and that the relative agonist and antagonist activity of 27HC is influenced by both cell and promoter context.	Oxysterols	67-76	estrogen receptor 1	Homo sapiens	191-193
18594022-4	2008	The cell-based high-throughput screen is conducted in a 96-well format using the human hepatoma HepG2 cells stably transfected with ABCA1 promoter-luciferase construct and calibrated with reference ABCA1 upregulators (oxysterols, 9-cis-retinoic acid, thiazolidinediones, cyclic adenosine monophosphate, verapamil, fenofibrate, and oncostatin M).	Oxysterols	218-228	ATP binding cassette subfamily A member 1	Homo sapiens	198-203
18186953-2	2008	In particular, apoptosis induced by the oxysterol 7 beta-hydroxycholesterol (7 beta-OH) has been associated with the generation of oxidative stress, cytochrome c release and caspase activation.	Oxysterols	40-49	cytochrome c, somatic	Homo sapiens	149-161
18186953-8	2008	Akt activation was decreased in the oxysterol-treated cells compared with control cells; however, this did not attain significance.	Oxysterols	36-45	AKT serine/threonine kinase 1	Homo sapiens	0-3
18676367-3	2008	Sterol regulatory element-binding protein-2 is responsive to both sterols and oxysterols and has been shown to mediate the transcriptional response of the cholesterologenic enzymes to these lipids.	Oxysterols	78-88	sterol regulatory element binding transcription factor 2	Homo sapiens	0-43
18676367-5	2008	Examination of the CYP51A1 gene revealed that both the SRE and nLXRE are required for normal oxysterol-dependent repression of this gene.	Oxysterols	93-102	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	19-26
18390616-9	2008	We attribute these effects to the reduction in intermolecular cohesive interactions caused by the presence of the second dipole of oxysterols, which reduces the energetic barrier for Abeta insertion into the bilayer.	Oxysterols	131-141	amyloid beta precursor protein	Homo sapiens	183-188
18614014-3	2008	T cell activation triggers induction of the oxysterol-metabolizing enzyme SULT2B1, consequent suppression of the LXR pathway for cholesterol transport, and promotion of the SREBP pathway for cholesterol synthesis.	Oxysterols	44-53	sulfotransferase family, cytosolic, 2B, member 1	Mus musculus	74-81
18614014-3	2008	T cell activation triggers induction of the oxysterol-metabolizing enzyme SULT2B1, consequent suppression of the LXR pathway for cholesterol transport, and promotion of the SREBP pathway for cholesterol synthesis.	Oxysterols	44-53	nuclear receptor subfamily 1, group H, member 2	Mus musculus	113-116
18569012-9	2008	Pharmacological intervention of GSK-3beta-JNK-caspase signalling pathway may be useful for the reduction of cytotoxicity of oxysterols.	Oxysterols	124-134	glycogen synthase kinase 3 beta	Rattus norvegicus	32-41
19110552-6	2008	Cholesterol-induced potentiation of the fibrogenic response is probably associated with transforming growth factor-beta1 induction due to accumulation of lipids and oxysterols in the liver.	Oxysterols	165-175	transforming growth factor, beta 1	Mus musculus	88-120
18450749-1	2008	Oxysterol binding to liver X receptors (LXR) increases the transcription of genes involved in cholesterol efflux and disposal, such as ABCA1 (ATP-binding cassette transporter A1).	Oxysterols	0-9	phospholipid-transporting ATPase ABCA1	Cricetulus griseus	135-140
18450749-1	2008	Oxysterol binding to liver X receptors (LXR) increases the transcription of genes involved in cholesterol efflux and disposal, such as ABCA1 (ATP-binding cassette transporter A1).	Oxysterols	0-9	phospholipid-transporting ATPase ABCA1	Cricetulus griseus	142-177
18450749-5	2008	Suppression of OSBP in Chinese hamster ovary cells by RNA interference resulted in increased ABCA1 protein expression and cholesterol efflux activity following induction with oxysterols or the synthetic LXR agonist TO901317.	Oxysterols	175-185	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	15-19
18450749-5	2008	Suppression of OSBP in Chinese hamster ovary cells by RNA interference resulted in increased ABCA1 protein expression and cholesterol efflux activity following induction with oxysterols or the synthetic LXR agonist TO901317.	Oxysterols	175-185	phospholipid-transporting ATPase ABCA1	Cricetulus griseus	93-98
18569012-9	2008	Pharmacological intervention of GSK-3beta-JNK-caspase signalling pathway may be useful for the reduction of cytotoxicity of oxysterols.	Oxysterols	124-134	mitogen-activated protein kinase 8	Rattus norvegicus	42-45
18646550-5	2008	CYP isoenzymes participate in metabolic pathways important for proper physiological functioning of the human organism, i.e.: cholesterol, bile acid and oxysterol biosynthesis; metabolism of fatty acids, prostaglandins, prostacyclins, leukotrienes, steroid hormones, ketone bodies, vitamines A and D. CYP isoenzymes participate in the metabolism of over 80% of drugs and other xenobiotic substances which can be present in the human organism.	Oxysterols	152-161	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
18646550-5	2008	CYP isoenzymes participate in metabolic pathways important for proper physiological functioning of the human organism, i.e.: cholesterol, bile acid and oxysterol biosynthesis; metabolism of fatty acids, prostaglandins, prostacyclins, leukotrienes, steroid hormones, ketone bodies, vitamines A and D. CYP isoenzymes participate in the metabolism of over 80% of drugs and other xenobiotic substances which can be present in the human organism.	Oxysterols	152-161	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	300-303
18395439-7	2008	In contrast, Ciona LXR was not activated by T-0901317 or GW3965 but was activated by a limited number of oxysterols, as well as some androstane and pregnane steroids.	Oxysterols	105-115	ecdysone receptor	Ciona intestinalis	19-22
18453540-5	2008	However, no doubt that TGF-beta1 level and activity may be upregulated in cells of the macrophage lineage by animal fat oxidation products, such as oxysterols and aldehydes, as reviewed here.	Oxysterols	148-158	transforming growth factor beta 1	Homo sapiens	23-32
18271871-5	2008	ABCA1 stimulates cholesterol efflux to lipid-poor apolipoproteins, whilst ABCG1 promotes efflux of cholesterol and oxysterols to HDL.	Oxysterols	115-125	ATP binding cassette subfamily G member 1	Homo sapiens	74-79
17872378-4	2008	However, the recent observation that oxysterols bind ER and antagonize the actions of 17beta-estradiol (E2) on the vascular wall suggests that this class of ligands may possess SERM activity.	Oxysterols	37-47	estrogen receptor 1	Homo sapiens	53-55
18055760-3	2008	In this study, we revealed a novel function of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critical for the homeostasis of cholesterol, bile acids, and oxysterols.	Oxysterols	192-202	RAR-related orphan receptor alpha	Mus musculus	47-55
18055760-3	2008	In this study, we revealed a novel function of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critical for the homeostasis of cholesterol, bile acids, and oxysterols.	Oxysterols	192-202	RAR-related orphan receptor alpha	Mus musculus	57-62
18055760-3	2008	In this study, we revealed a novel function of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critical for the homeostasis of cholesterol, bile acids, and oxysterols.	Oxysterols	192-202	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	82-110
18055760-3	2008	In this study, we revealed a novel function of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critical for the homeostasis of cholesterol, bile acids, and oxysterols.	Oxysterols	192-202	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	112-118
18029360-11	2008	Cholesterol or oxysterols induced ABCA1 expression in wild type macrophages but had little or inhibitory effects on ABCA1 expression in LDLR(-/-) macrophages.	Oxysterols	15-25	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	34-39
18029360-15	2008	Oxysterol synergized with nonsteroid LXR ligand induced ABCA1 expression in wild type macrophages but blocked induction in LDLR(-/-) cells.	Oxysterols	0-9	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	56-61
18029360-15	2008	Oxysterol synergized with nonsteroid LXR ligand induced ABCA1 expression in wild type macrophages but blocked induction in LDLR(-/-) cells.	Oxysterols	0-9	low density lipoprotein receptor	Mus musculus	123-127
17989072-5	2008	We showed earlier that NPC1 binds cholesterol and oxysterols.	Oxysterols	50-60	NPC intracellular cholesterol transporter 1	Cricetulus griseus	23-27
17989073-5	2008	Unexpectedly, we encountered NPC1 in a search for a membrane protein that binds 25-hydroxycholesterol (25-HC) and other oxysterols.	Oxysterols	120-130	NPC intracellular cholesterol transporter 1	Homo sapiens	29-33
17989073-7	2008	We prepared recombinant human NPC1 and confirmed its ability to bind oxysterols, including those with a hydroxyl group on the 24, 25, or 27 positions.	Oxysterols	69-79	NPC intracellular cholesterol transporter 1	Homo sapiens	30-34
17989073-13	2008	The availability of assays to measure NPC1 binding in vitro may further the understanding of ways in which oxysterols regulate intracellular lipid transport.	Oxysterols	107-117	NPC intracellular cholesterol transporter 1	Homo sapiens	38-42
17938859-1	2008	OSBP (oxysterol-binding protein) and ORPs (OSBP-related proteins) constitute an enigmatic eukaryotic protein family that is united by a signature domain that binds oxysterols, sterols, and possibly other hydrophobic ligands.	Oxysterols	164-174	oxysterol binding protein	Homo sapiens	0-4
17938859-1	2008	OSBP (oxysterol-binding protein) and ORPs (OSBP-related proteins) constitute an enigmatic eukaryotic protein family that is united by a signature domain that binds oxysterols, sterols, and possibly other hydrophobic ligands.	Oxysterols	164-174	oxysterol binding protein	Homo sapiens	43-47
18068744-9	2008	Perhaps surprisingly, the retina expresses CYP 27A1 and CYP 46A1, enzymes with broad substrate specificity for ring-modified sterols, implying that, in addition to a rich blood supply for disposing of potentially toxic oxysterols, they can be detoxified locally.	Oxysterols	219-229	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	43-51
18068744-9	2008	Perhaps surprisingly, the retina expresses CYP 27A1 and CYP 46A1, enzymes with broad substrate specificity for ring-modified sterols, implying that, in addition to a rich blood supply for disposing of potentially toxic oxysterols, they can be detoxified locally.	Oxysterols	219-229	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	56-64
17846428-6	2007	In transfected 293 cells, efflux of 7-ketocholesterol and related oxysterols was completely dependent on expression of ABCG1 and the presence of HDL in media.	Oxysterols	66-76	ATP binding cassette subfamily G member 1	Homo sapiens	119-124
18056036-6	2007	The net mural response to these stimuli promotes osteogenic differentiation of calcifying vascular cells, moreover, oxidation of vascular LDL cholesterol generates oxysterols that trigger Runx2 activity via hedgehog pathways.	Oxysterols	164-174	RUNX family transcription factor 2	Homo sapiens	188-193
17887732-4	2007	The response of the ABCA1 gene to oxysterols/retinoids as well as the ligand-inducible recruitment of Sp1 and RXRalpha/LXRalpha heterodimers to the ABCA1 promoter was blocked by mithramycin A, a well-known Sp1 inhibitor.	Oxysterols	34-44	ATP binding cassette subfamily A member 1	Homo sapiens	20-25
17887732-8	2007	Overall, the present study revealed a novel mechanism of regulation of the human ABCA1 transporter which involves synergistic interactions between oxysterol/retinoid-inducible hormone nuclear receptors and the transcription factor Sp1.	Oxysterols	147-156	ATP binding cassette subfamily A member 1	Homo sapiens	81-86
17846428-10	2007	These findings indicate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and related oxysterols from macrophages onto HDL and in protecting these cells from oxysterol-induced cytotoxicity.	Oxysterols	103-112	ATP binding cassette subfamily G member 1	Homo sapiens	44-49
22820672-4	2008	The inhibitory effects of oxysterols and TO901317 on the Pcyt2 promoter function, mRNA and protein expression were conserved in the human breast cancer cells MCF-7.	Oxysterols	26-36	phosphate cytidylyltransferase 2, ethanolamine	Homo sapiens	57-62
17638575-12	2007	To elucidate the molecular mechanism(s) by which 20S inhibits PPARgamma expression and adipogenic differentiation, we focused on the hedgehog signaling pathway, which we previously showed to be the mediator of osteogenic responses to oxysterols.	Oxysterols	234-244	DNA segment, 20S	Mus musculus	49-52
17887732-0	2007	Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids.	Oxysterols	186-196	ATP binding cassette subfamily A member 1	Homo sapiens	142-177
17887732-3	2007	In the present study, we show that the oxysterol/retinoid-induced transcription of the ABCA1 gene is modulated by the ubiquitous transcription factor Sp1 that binds to the proximal ABCA1 promoter, adjacently to the LXR/RXR responsive element.	Oxysterols	39-48	ATP binding cassette subfamily A member 1	Homo sapiens	87-92
17887732-3	2007	In the present study, we show that the oxysterol/retinoid-induced transcription of the ABCA1 gene is modulated by the ubiquitous transcription factor Sp1 that binds to the proximal ABCA1 promoter, adjacently to the LXR/RXR responsive element.	Oxysterols	39-48	ATP binding cassette subfamily A member 1	Homo sapiens	181-186
17887732-3	2007	In the present study, we show that the oxysterol/retinoid-induced transcription of the ABCA1 gene is modulated by the ubiquitous transcription factor Sp1 that binds to the proximal ABCA1 promoter, adjacently to the LXR/RXR responsive element.	Oxysterols	39-48	retinoid X receptor alpha	Homo sapiens	219-222
17573819-4	2007	Following their interaction with oxysterols, activation of LXRs induces the expression of ATP-binding cassette, sub-family A member 1, a pivotal modulator of cholesterol efflux.	Oxysterols	33-43	ATP binding cassette subfamily A member 1	Homo sapiens	90-133
17624300-1	2007	Recently, a novel oxysterol, 5-cholesten-3beta, 25-diol 3-sulfate (25HC3S) was identified in primary rat hepatocytes following overexpression of the cholesterol transport protein, StarD1.	Oxysterols	18-27	steroidogenic acute regulatory protein	Rattus norvegicus	180-186
17573819-6	2007	Oxysterol-mediated LXR activation induces local apoE biosynthesis (predominantly in astrocytes) further enhancing cholesterol re-distribution and removal.	Oxysterols	0-9	apolipoprotein E	Homo sapiens	48-52
17573819-9	2007	Stress-induced up-regulation of the heme-degrading enzyme, heme oxygenase-1 in AD-affected astroglia may impact central lipid homeostasis by promoting the oxidation of cholesterol to a host of oxysterol intermediates.	Oxysterols	193-202	heme oxygenase 1	Homo sapiens	59-75
17408620-5	2007	In the current study, we investigated whether ABC transporter family member G1 (ABCG1) may be involved in oxysterol transport, since its gene expression is highly responsive to oxysterol loading.	Oxysterols	106-115	ATP binding cassette subfamily G member 1	Homo sapiens	80-85
17550979-7	2007	Because Mvk expression is regulated by sterol response element-binding protein-1, which is sensitive to the cellular concentration of 25-hydroxycholesterol (25-OHC), cultured granulosa cells were treated with this oxysterol, and the expression of Mvk gene was examined.	Oxysterols	214-223	mevalonate kinase	Homo sapiens	8-11
17550979-7	2007	Because Mvk expression is regulated by sterol response element-binding protein-1, which is sensitive to the cellular concentration of 25-hydroxycholesterol (25-OHC), cultured granulosa cells were treated with this oxysterol, and the expression of Mvk gene was examined.	Oxysterols	214-223	mevalonate kinase	Homo sapiens	247-250
17550979-10	2007	The results showed that the decrease in Mvk expression by oxysterol treatment abrogated ligand-induced down-regulation of LHR mRNA.	Oxysterols	58-67	mevalonate kinase	Homo sapiens	40-43
17550979-10	2007	The results showed that the decrease in Mvk expression by oxysterol treatment abrogated ligand-induced down-regulation of LHR mRNA.	Oxysterols	58-67	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	122-125
17296605-7	2007	These results indicate that LXRalpha is regulated not only by oxysterol derivatives but also by PKA-mediated phosphorylation, which suggests that nutritional regulation of SREBP-1c and lipogenesis could be regulated at least partially through modulation of LXR.	Oxysterols	62-71	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	28-36
17428919-1	2007	Two classes of sterols, cholesterol and oxysterols, block export of sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum (ER) to the Golgi by preventing the binding of COPII-coated proteins to a hexapeptide sorting signal (MELADL) in Scap, the SREBP-escort protein.	Oxysterols	40-50	SREBF chaperone	Homo sapiens	264-268
17428919-3	2007	Cholesterol and oxysterols block COPII binding to MELADL by binding to different intracellular receptors, cholesterol to Scap and oxysterols to Insig.	Oxysterols	16-26	SREBF chaperone	Homo sapiens	121-125
17428920-4	2007	Here, we show that oxysterols act by binding to Insigs, causing Insigs to bind to Scap.	Oxysterols	19-29	SREBF chaperone	Homo sapiens	82-86
17408620-5	2007	In the current study, we investigated whether ABC transporter family member G1 (ABCG1) may be involved in oxysterol transport, since its gene expression is highly responsive to oxysterol loading.	Oxysterols	177-186	ATP binding cassette subfamily G member 1	Homo sapiens	80-85
17200122-5	2007	This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyclopamine, and 4) unresponsiveness of Smoothened-/- mouse embryonic fibroblasts to oxysterols.	Oxysterols	28-37	GLI-Kruppel family member GLI1	Mus musculus	80-100
17031848-5	2007	Furthermore, oxysterol-induced-osteoblastic differentiation is marked by the prolonged DNA-binding activity of Runx2 in M2-10B4 bone marrow stromal cells (MSCs) and C3H10T1/2 embryonic fibroblastic cells.	Oxysterols	13-22	runt related transcription factor 2	Mus musculus	111-116
17031848-7	2007	PKC- and PKA-dependent mechanisms appear to also regulate other markers of osteoblastic differentiation including alkaline phosphatase (ALP) activity and osteocalcin mRNA expression in response to oxysterols.	Oxysterols	197-207	bone gamma-carboxyglutamate protein 2	Mus musculus	154-165
17031848-9	2007	Since Runx2 is an indispensable factor that regulates the differentiation of osteoblastic cells and bone formation in vitro and in vivo, its increased activity in oxysterol-treated cells further validates the potential role of oxysterols in lineage-specific differentiation of pluripotent mesenchymal cells and their potential therapeutic use as bone anabolic factors.	Oxysterols	163-172	runt related transcription factor 2	Mus musculus	6-11
17200122-5	2007	This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyclopamine, and 4) unresponsiveness of Smoothened-/- mouse embryonic fibroblasts to oxysterols.	Oxysterols	102-111	GLI-Kruppel family member GLI1	Mus musculus	80-100
17200122-5	2007	This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyclopamine, and 4) unresponsiveness of Smoothened-/- mouse embryonic fibroblasts to oxysterols.	Oxysterols	102-111	smoothened, frizzled class receptor	Mus musculus	315-325
17200122-5	2007	This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyclopamine, and 4) unresponsiveness of Smoothened-/- mouse embryonic fibroblasts to oxysterols.	Oxysterols	102-111	GLI-Kruppel family member GLI1	Mus musculus	80-100
17200122-5	2007	This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyclopamine, and 4) unresponsiveness of Smoothened-/- mouse embryonic fibroblasts to oxysterols.	Oxysterols	102-111	smoothened, frizzled class receptor	Mus musculus	315-325
17200122-5	2007	This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyclopamine, and 4) unresponsiveness of Smoothened-/- mouse embryonic fibroblasts to oxysterols.	Oxysterols	360-370	GLI-Kruppel family member GLI1	Mus musculus	80-100
17364953-3	2007	Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not IkappaBalpha degradation or tumour necrosis factor-alpha release from monocytic THP-1 cells.	Oxysterols	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
16730733-2	2007	We previously demonstrated that unsaturated fatty acids suppress the stimulatory effects of oxysterols and retinoids on ABCA1 gene transcription.	Oxysterols	92-102	ATP binding cassette subfamily A member 1	Homo sapiens	120-125
16730733-3	2007	We here demonstrate that unsaturated fatty acids significantly suppress the stimulatory effects of oxysterols and retinoids on the expression of ABCG1 mRNA and protein and the activity of the wild-type human ABCG1 promoter as well as ABCA1.	Oxysterols	99-109	ATP binding cassette subfamily G member 1	Homo sapiens	145-150
16730733-3	2007	We here demonstrate that unsaturated fatty acids significantly suppress the stimulatory effects of oxysterols and retinoids on the expression of ABCG1 mRNA and protein and the activity of the wild-type human ABCG1 promoter as well as ABCA1.	Oxysterols	99-109	ATP binding cassette subfamily G member 1	Homo sapiens	208-213
17320768-3	2007	In the current study, we demonstrated that transient transfection of rat astroglia with human (h)ho-1 cDNA for 3 days significantly decreased intracellular cholesterol concentrations and increased levels of four oxysterol species (measured by GC/MS) compared to untreated control cultures and HO-1-transfected cells exposed to the HO inhibitor, tin mesoporphyrin (SnMP).	Oxysterols	212-221	heme oxygenase 1	Homo sapiens	97-101
17364953-3	2007	Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not IkappaBalpha degradation or tumour necrosis factor-alpha release from monocytic THP-1 cells.	Oxysterols	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
16901265-13	2006	In addition, our results indicate a critical role of SREBP-2 as a positive regulator of ABCA1 gene expression by enabling the generation of oxysterol ligands for LXR.	Oxysterols	140-149	sterol regulatory element binding transcription factor 2	Homo sapiens	53-60
17393208-1	2007	Oxygenated derivates of cholesterol and lanosterol, known as oxysterols, have consistently displayed significant activity as inhibitors of 3-hydroxy-3-methylglutaryl (HMG) CoA reductase, a key regulatory enzyme in sterol biosynthesis.	Oxysterols	61-71	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	139-185
17189208-0	2007	Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.	Oxysterols	23-33	nuclear receptor subfamily 1, group H, member 3	Mus musculus	42-45
17189208-3	2007	Here we provide two lines of evidence that oxysterols are LXR ligands in vitro and in vivo.	Oxysterols	43-53	nuclear receptor subfamily 1, group H, member 3	Mus musculus	58-61
17189208-4	2007	First, overexpression of an oxysterol catabolic enzyme, cholesterol sulfotransferase, inactivates LXR signaling in several cultured mammalian cell lines but does not alter receptor response to the nonsterol agonist T0901317.	Oxysterols	28-37	nuclear receptor subfamily 1, group H, member 3	Mus musculus	98-101
17189208-6	2007	Second, triple-knockout mice deficient in the biosynthesis of three oxysterol ligands of LXRs, 24S-hydroxycholesterol, 25-hydroxycholesterol, and 27-hydroxycholesterol, respond to dietary T0901317 by inducing LXR target genes in liver but show impaired responses to dietary cholesterol.	Oxysterols	68-77	nuclear receptor subfamily 1, group H, member 3	Mus musculus	89-92
17189208-7	2007	We conclude that oxysterols are in vivo ligands for LXR.	Oxysterols	17-27	nuclear receptor subfamily 1, group H, member 3	Mus musculus	52-55
17164181-0	2007	Cytotoxic effects of oxysterols produced during ozonolysis of cholesterol in murine GT1-7 hypothalamic neurons.	Oxysterols	21-31	retinoic acid induced 1	Mus musculus	84-87
16901265-0	2006	SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR.	Oxysterols	96-105	sterol regulatory element binding transcription factor 2	Homo sapiens	0-7
16901265-0	2006	SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR.	Oxysterols	96-105	ATP binding cassette subfamily A member 1	Homo sapiens	75-80
16901265-13	2006	In addition, our results indicate a critical role of SREBP-2 as a positive regulator of ABCA1 gene expression by enabling the generation of oxysterol ligands for LXR.	Oxysterols	140-149	ATP binding cassette subfamily A member 1	Homo sapiens	88-93
17073762-1	2006	The LXRs (liver X receptors) (LXRalpha and LXRbeta) are nuclear hormone receptors that are activated by oxysterols, endogenous oxidative metabolites of cholesterol.	Oxysterols	104-114	nuclear receptor subfamily 1, group H, member 3	Mus musculus	30-38
17073762-1	2006	The LXRs (liver X receptors) (LXRalpha and LXRbeta) are nuclear hormone receptors that are activated by oxysterols, endogenous oxidative metabolites of cholesterol.	Oxysterols	104-114	nuclear receptor subfamily 1, group H, member 2	Mus musculus	43-50
17073762-4	2006	In the adrenal gland, oxysterols are formed as intermediates in the conversion of cholesterol into steroid hormones and can act as endogenous activators of LXR.	Oxysterols	22-32	nuclear receptor subfamily 1, group H, member 2	Mus musculus	156-159
17018531-10	2006	In addition, we find that NPC2 binds a range of cholesterol-related molecules (cholesterol precursors, plant sterols, some oxysterols, cholesterol sulfate, cholesterol acetate, and 5-alpha-cholestan-3-one) and that 27-hydroxysterol accumulates in NPC2-deficient mouse liver.	Oxysterols	123-133	NPC intracellular cholesterol transporter 2	Mus musculus	26-30
16825952-2	2006	Increased immunolabeling to cholesterol and the oxysterol biosynthetic enzyme, cholesterol 24-hydroxylase, was observed in the rat hippocampus after kainate lesions.	Oxysterols	48-57	cytochrome P450, family 46, subfamily a, polypeptide 1	Rattus norvegicus	79-105
16983501-5	2006	The specific activities of antioxidant enzymes superoxide dismutase and catalase were increased to different extents (1.17- to 6.43-fold), relative to controls, by the administration of individual oxysterols and the oxysterol mixture.	Oxysterols	197-207	catalase	Bos taurus	72-80
16983501-5	2006	The specific activities of antioxidant enzymes superoxide dismutase and catalase were increased to different extents (1.17- to 6.43-fold), relative to controls, by the administration of individual oxysterols and the oxysterol mixture.	Oxysterols	197-206	catalase	Bos taurus	72-80
17082746-1	2006	OSH3 is one of the seven yeast homologues of the oxysterol binding proteins (OSBPs) which have the major binding affinity to the oxysterols and function as regulator of cholesterol biosynthesis in mammals.	Oxysterols	129-139	oxysterol-binding protein related protein OSH3	Saccharomyces cerevisiae S288C	0-4
17082746-2	2006	Mutational analysis of OSH3 showed that OSH3 plays a regulatory role in the yeast-to-hyphal transition through its oxysterol-binding domain in Saccharomyces cerevisiae.	Oxysterols	115-124	oxysterol-binding protein related protein OSH3	Saccharomyces cerevisiae S288C	23-27
17082746-2	2006	Mutational analysis of OSH3 showed that OSH3 plays a regulatory role in the yeast-to-hyphal transition through its oxysterol-binding domain in Saccharomyces cerevisiae.	Oxysterols	115-124	oxysterol-binding protein related protein OSH3	Saccharomyces cerevisiae S288C	40-44
16940355-3	2006	We show that the neurosteroid allopregnanolone (ALLO) and T0901317, a synthetic oxysterol ligand, act in concert to delay onset of neurological symptoms and prolong the lifespan of npc1(-/-) mice.	Oxysterols	80-89	NPC intracellular cholesterol transporter 1	Mus musculus	181-185
16871576-7	2006	In conclusion, these observations establish LXRalpha as a crucial regulator of bile acid glucuronidation in humans and suggest that accumulation of oxysterols in hepatocytes during cholestasis favors bile acid detoxification as glucuronide conjugates.	Oxysterols	148-158	nuclear receptor subfamily 1 group H member 3	Homo sapiens	44-52
17053191-7	2006	Upregulation of ABCA1 with oxysterols increased apoA-I binding and internalization.	Oxysterols	27-37	ATP binding cassette subfamily A member 1	Homo sapiens	16-21
17053191-7	2006	Upregulation of ABCA1 with oxysterols increased apoA-I binding and internalization.	Oxysterols	27-37	apolipoprotein A1	Homo sapiens	48-54
16920108-1	2006	Liver X receptor alpha (LXRalpha) is a member of the nuclear receptor superfamily that is activated by oxysterols, and plays a pivotal role in regulating the metabolism, transport and uptake of cholesterol.	Oxysterols	103-113	nuclear receptor subfamily 1 group H member 3	Homo sapiens	24-32
16611739-0	2006	ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells.	Oxysterols	102-111	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
16611739-8	2006	Evidence from in vitro studies indicates that oxysterols are potent inducers of genes involved in cellular cholesterol efflux and metabolism, including the ABCA1 gene, and repressors of genes involved in cholesterol synthesis or uptake.	Oxysterols	46-56	ATP binding cassette subfamily A member 1	Homo sapiens	156-161
16941710-6	2006	These increases were associated with activation of liver X receptor alpha (LXRalpha) as a result of the increased tissue oxysterol concentrations.	Oxysterols	121-130	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	51-73
16941710-6	2006	These increases were associated with activation of liver X receptor alpha (LXRalpha) as a result of the increased tissue oxysterol concentrations.	Oxysterols	121-130	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	75-83
16941710-9	2006	In addition, bile acid biosynthesis was inhibited despite the reduced expression of the small heterodimer partner (SHP) and activated LXRalpha, which also appeared to contribute to the accumulation of oxysterols followed by the acceleration of cholesterol efflux.	Oxysterols	201-211	nuclear receptor subfamily 0, group B, member 2	Rattus norvegicus	115-118
16941710-9	2006	In addition, bile acid biosynthesis was inhibited despite the reduced expression of the small heterodimer partner (SHP) and activated LXRalpha, which also appeared to contribute to the accumulation of oxysterols followed by the acceleration of cholesterol efflux.	Oxysterols	201-211	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	134-142
16941710-11	2006	Overexpression of the SREBP processing system contributed to the activation of LXRalpha by maintaining high oxysterol levels in tissue.	Oxysterols	108-117	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	79-87
16604541-8	2006	RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway.	Oxysterols	13-23	mitogen-activated protein kinase 3	Homo sapiens	150-156
16571669-2	2006	One mechanism for regulation of this metabolic interface involves oxysterol binding protein (OSBP) via high-affinity binding to oxysterol regulators of cholesterol homeostasis and activation of SM synthesis at the Golgi apparatus.	Oxysterols	66-75	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	93-97
16571669-5	2006	Additional RNAi experiments in human embryonic kidney 293 cells supported OSBP involvement in oxysterol-activated SM synthesis and also revealed a role for OSBP in basal SM synthesis.	Oxysterols	94-103	oxysterol binding protein	Homo sapiens	74-78
16604541-8	2006	RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway.	Oxysterols	13-23	C-C motif chemokine ligand 2	Homo sapiens	69-74
16707575-4	2006	Here we show that cholesterol or specific oxysterols are the critical products of sterol synthesis required for Shh pathway signal transduction in MB cells.	Oxysterols	42-52	sonic hedgehog signaling molecule	Homo sapiens	112-115
16707575-7	2006	We also show that certain oxysterols can maximally activate Shh target gene transcription through the Smoothened (Smo) protein as effectively as the known Smo full agonist, SAG.	Oxysterols	26-36	sonic hedgehog signaling molecule	Homo sapiens	60-63
16707575-7	2006	We also show that certain oxysterols can maximally activate Shh target gene transcription through the Smoothened (Smo) protein as effectively as the known Smo full agonist, SAG.	Oxysterols	26-36	smoothened, frizzled class receptor	Homo sapiens	102-112
16707575-7	2006	We also show that certain oxysterols can maximally activate Shh target gene transcription through the Smoothened (Smo) protein as effectively as the known Smo full agonist, SAG.	Oxysterols	26-36	smoothened, frizzled class receptor	Homo sapiens	102-105
16707575-7	2006	We also show that certain oxysterols can maximally activate Shh target gene transcription through the Smoothened (Smo) protein as effectively as the known Smo full agonist, SAG.	Oxysterols	26-36	smoothened, frizzled class receptor	Homo sapiens	114-117
16505492-1	2006	This study reports the discovery of a novel sulfonated oxysterol found at high levels in the mitochondria and nuclei of primary rat hepatocytes after overexpression of the gene encoding steroidogenic acute regulatory protein (StarD1).	Oxysterols	55-64	steroidogenic acute regulatory protein	Rattus norvegicus	186-224
16604541-8	2006	RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway.	Oxysterols	13-23	C-C motif chemokine ligand 4	Homo sapiens	76-85
16604541-8	2006	RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway.	Oxysterols	13-23	tumor necrosis factor	Homo sapiens	87-96
16604541-8	2006	RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway.	Oxysterols	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
16604541-8	2006	RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway.	Oxysterols	13-23	mitogen-activated protein kinase kinase 7	Homo sapiens	146-149
16505492-1	2006	This study reports the discovery of a novel sulfonated oxysterol found at high levels in the mitochondria and nuclei of primary rat hepatocytes after overexpression of the gene encoding steroidogenic acute regulatory protein (StarD1).	Oxysterols	55-64	steroidogenic acute regulatory protein	Rattus norvegicus	226-232
16371446-4	2006	We hypothesized that the expression of BSEP was induced by oxysterols through activation of LXR.	Oxysterols	59-69	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
16371446-6	2006	The level of BSEP mRNA was increased as much as 5-fold upon oxysterol induction.	Oxysterols	60-69	ATP binding cassette subfamily B member 11	Homo sapiens	13-17
16371446-7	2006	In contrast to our hypothesis, the oxysterol-induced up-regulation of BSEP is mediated through FXR but not LXR.	Oxysterols	35-44	ATP binding cassette subfamily B member 11	Homo sapiens	70-74
16371446-7	2006	In contrast to our hypothesis, the oxysterol-induced up-regulation of BSEP is mediated through FXR but not LXR.	Oxysterols	35-44	nuclear receptor subfamily 1 group H member 4	Homo sapiens	95-98
16371446-9	2006	Mutation of the FXR element IR1 in the BSEP promoter significantly reduced its ability to respond to oxysterol induction.	Oxysterols	101-110	nuclear receptor subfamily 1 group H member 4	Homo sapiens	16-19
16371446-9	2006	Mutation of the FXR element IR1 in the BSEP promoter significantly reduced its ability to respond to oxysterol induction.	Oxysterols	101-110	nischarin	Homo sapiens	28-31
16371446-9	2006	Mutation of the FXR element IR1 in the BSEP promoter significantly reduced its ability to respond to oxysterol induction.	Oxysterols	101-110	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
16303770-7	2006	Chromatin immunoprecipitation assay confirmed that KLF13 binds proximal LDLR DNA sequences in vivo and that exogenous oxysterol up-regulates such binding.	Oxysterols	118-127	low density lipoprotein receptor	Homo sapiens	72-76
17086498-4	2005	Thus, we investigated the effect of oxysterols, including 25-hydroxycholesterol and 7beta-hydroxycholesterol, on IL-1beta-induced IL-8 production in Caco-2 cells (a human colon carcinoma cell line).	Oxysterols	36-46	interleukin 1 beta	Homo sapiens	113-121
16408938-6	2006	Osh5p from yeast is the first oxysterol binding protein homologue for which oxysterol binding is shown with this new technique.	Oxysterols	30-39	oxysterol-binding protein related protein HES1	Saccharomyces cerevisiae S288C	0-5
16099444-8	2005	Furthermore, oxLDL inhibited exogenous cholesterol- and oxysterol-induced endothelial ABCA1 induction.	Oxysterols	56-65	ATP binding cassette subfamily A member 1	Homo sapiens	86-91
15993097-9	2005	This is the first report demonstrating induction of TNF-alpha-mediated death by oxysterol in cells.	Oxysterols	80-89	tumor necrosis factor	Homo sapiens	52-61
16245954-0	2005	Role of oxysterol structure on the microdomain-induced microsolubilization of phospholipid membranes by apolipoprotein A-I.	Oxysterols	8-17	apolipoprotein A1	Homo sapiens	104-122
16245954-2	2005	The kinetics of microsolubilization of dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles by apolipoprotein A-I (apoA-I) to form discoidal high-density lipoproteins (rHDL) was dramatically affected by oxysterol chemical structure.	Oxysterols	211-220	apolipoprotein A1	Homo sapiens	103-121
16245954-2	2005	The kinetics of microsolubilization of dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles by apolipoprotein A-I (apoA-I) to form discoidal high-density lipoproteins (rHDL) was dramatically affected by oxysterol chemical structure.	Oxysterols	211-220	apolipoprotein A1	Homo sapiens	123-129
16214031-0	2005	Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells.	Oxysterols	0-9	C-C motif chemokine ligand 2	Homo sapiens	35-40
16214031-5	2005	Up-regulated expression and synthesis of MCP-1 by the oxysterol mixture was clearly dependent on a net increment of phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor kappaB (NF-kappaB) nuclear binding.	Oxysterols	54-63	C-C motif chemokine ligand 2	Homo sapiens	41-46
16214031-5	2005	Up-regulated expression and synthesis of MCP-1 by the oxysterol mixture was clearly dependent on a net increment of phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor kappaB (NF-kappaB) nuclear binding.	Oxysterols	54-63	mitogen-activated protein kinase 1	Homo sapiens	135-176
16214031-5	2005	Up-regulated expression and synthesis of MCP-1 by the oxysterol mixture was clearly dependent on a net increment of phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor kappaB (NF-kappaB) nuclear binding.	Oxysterols	54-63	mitogen-activated protein kinase 3	Homo sapiens	178-184
16214031-5	2005	Up-regulated expression and synthesis of MCP-1 by the oxysterol mixture was clearly dependent on a net increment of phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor kappaB (NF-kappaB) nuclear binding.	Oxysterols	54-63	nuclear factor kappa B subunit 1	Homo sapiens	205-211
16214031-5	2005	Up-regulated expression and synthesis of MCP-1 by the oxysterol mixture was clearly dependent on a net increment of phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor kappaB (NF-kappaB) nuclear binding.	Oxysterols	54-63	nuclear factor kappa B subunit 1	Homo sapiens	213-222
15880703-9	2005	The protective effect of the oxysterols against oxidative stress was dependent on cyclooxygenase 1 and was associated with the osteogenic property of the oxysterols.	Oxysterols	29-39	prostaglandin-endoperoxide synthase 1	Mus musculus	82-98
16270277-6	2005	As for HNE, the challenge of cells of the macrophage lineage with a mixture of oxysterols like that detectable in hypercholesterolemic individuals led to a marked overexpression of TGFbeta1 and MCP-1.	Oxysterols	79-89	transforming growth factor beta 1	Homo sapiens	181-189
16270277-6	2005	As for HNE, the challenge of cells of the macrophage lineage with a mixture of oxysterols like that detectable in hypercholesterolemic individuals led to a marked overexpression of TGFbeta1 and MCP-1.	Oxysterols	79-89	C-C motif chemokine ligand 2	Homo sapiens	194-199
15995174-0	2005	Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages.	Oxysterols	66-75	carboxylesterase 1G	Mus musculus	0-43
15897605-7	2005	In contrast to selective cholesterol binding by StarD1, StarD5 bound the potent regulatory oxysterol, 25-hydroxycholesterol, in a concentration-dependent manner.	Oxysterols	91-100	StAR related lipid transfer domain containing 5	Homo sapiens	56-62
15897605-9	2005	The ability of StarD5 to bind not only cholesterol but also 25-hydroxycholesterol, a potent inflammatory mediator and regulatory oxysterol, raises basic fundamental questions about StarD5"s role in the maintenance of cellular cholesterol homeostasis.	Oxysterols	129-138	StAR related lipid transfer domain containing 5	Homo sapiens	15-21
15788406-0	2005	Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase.	Oxysterols	0-10	mitogen-activated protein kinase 1	Homo sapiens	53-56
15930522-5	2005	In particular, in vitro data suggest that oxysterols via the liver X receptor (LXR) inhibit phenobarbital (PB)-mediated induction of CYPs.	Oxysterols	42-52	nuclear receptor subfamily 1, group H, member 2	Mus musculus	61-77
15930522-5	2005	In particular, in vitro data suggest that oxysterols via the liver X receptor (LXR) inhibit phenobarbital (PB)-mediated induction of CYPs.	Oxysterols	42-52	nuclear receptor subfamily 1, group H, member 2	Mus musculus	79-82
15788406-2	2005	We observed that the oxysterol 22-hydroxycholesterol (22-HC) in combination with its obligate partner, 9-cis-retinoic acid (9-cis-RA), decreased surfactant phosphatidylcholine (PtdCho) synthesis by increasing phosphorylation of the regulatory enzyme CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha).	Oxysterols	21-30	phosphate cytidylyltransferase 1A, choline	Homo sapiens	250-295
15788406-2	2005	We observed that the oxysterol 22-hydroxycholesterol (22-HC) in combination with its obligate partner, 9-cis-retinoic acid (9-cis-RA), decreased surfactant phosphatidylcholine (PtdCho) synthesis by increasing phosphorylation of the regulatory enzyme CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha).	Oxysterols	21-30	phosphate cytidylyltransferase 1A, choline	Homo sapiens	297-305
15788406-6	2005	Expression of truncated CCTalpha mutants lacking proline-directed sites within the C-terminal phosphorylation domain partially blocked oxysterol-mediated inhibition of PtdCho synthesis.	Oxysterols	135-144	phosphate cytidylyltransferase 1A, choline	Homo sapiens	24-32
16403982-4	2005	As previously demonstrated for other lipid oxidation products present in LDL, namely a biologically representative mixture of oxysterols and the unesterified aldehyde 4-hydroxynonenal, these effects on TGFbeta1 by 9-ONC further points to LDL lipid oxidation as a powerful source of pro-fibrogenic stimuli.	Oxysterols	126-136	transforming growth factor beta 1	Homo sapiens	202-210
16054077-2	2005	Liver X receptors (LXRs) are oxysterol sensors that are required for normal cholesterol and triglyceride homeostasis, yet synthetic LXR agonists produce undesirable hypertriglyceridemia.	Oxysterols	29-38	nuclear receptor subfamily 1, group H, member 3	Mus musculus	19-22
15499039-4	2005	Activation of Bax also occurs in free cholesterol-loaded and oxysterol-treated mouse macrophages.	Oxysterols	61-70	BCL2-associated X protein	Mus musculus	14-17
15907394-6	2005	Similar Golgi-ER targeting motifs are also present in the oxysterol-binding protein (OSBP), which regulates ceramide transport and SM synthesis in an oxysterol-dependent manner.	Oxysterols	58-67	oxysterol binding protein	Homo sapiens	85-89
15649656-11	2005	Finally, both isoforms of oxysterols directly released cytochrome c only in conjunction with protein containing cytosol and endoplasmatic reticulum.	Oxysterols	26-36	cytochrome c, somatic	Homo sapiens	55-67
15509573-3	2005	Studies have shown that SREBP-1c expression is dependent on insulin but also on the availability of oxysterols, ligands of the nuclear liver X receptor (LXR).	Oxysterols	100-110	sterol regulatory element binding transcription factor 1	Homo sapiens	24-32
15242983-8	2004	We demonstrated that only oxLDL containing a high proportion of oxysterols and phosphatidylcholine hydroperoxide derivatives that provide ligands for liver X receptor (LXR) and peroxisomal proliferator-activated receptor gamma (PPARgamma), respectively, reduced trophoblast invasion.	Oxysterols	64-74	peroxisome proliferator activated receptor gamma	Homo sapiens	228-237
15364622-10	2004	However, none of these cell death markers was rescued when the SMCs had been exposed to the oxysterol for 24 h. CONCLUSION: The results indicate that cytochrome c release during oxysterol-induced SMC apoptosis is not caspase-dependent and occurs as a result of a reversible mitochondrial conformational change rather than swelling and rupture of the outer membrane.	Oxysterols	178-187	cytochrome c	Oryctolagus cuniculus	150-162
15242983-8	2004	We demonstrated that only oxLDL containing a high proportion of oxysterols and phosphatidylcholine hydroperoxide derivatives that provide ligands for liver X receptor (LXR) and peroxisomal proliferator-activated receptor gamma (PPARgamma), respectively, reduced trophoblast invasion.	Oxysterols	64-74	peroxisome proliferator activated receptor gamma	Homo sapiens	177-226
15292374-4	2004	A newly characterized synthetic oxysterol, N,N-dimethyl-3beta-hydroxycholenamide (DMHCA), represents a gene-selective LXR modulator that mediates potent transcriptional activation of ABCA1 gene expression while exhibiting minimal effects on SREBP-1c both in vitro and in vivo in mice.	Oxysterols	32-41	nuclear receptor subfamily 1, group H, member 3	Mus musculus	118-121
15292374-4	2004	A newly characterized synthetic oxysterol, N,N-dimethyl-3beta-hydroxycholenamide (DMHCA), represents a gene-selective LXR modulator that mediates potent transcriptional activation of ABCA1 gene expression while exhibiting minimal effects on SREBP-1c both in vitro and in vivo in mice.	Oxysterols	32-41	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	183-188
15292374-4	2004	A newly characterized synthetic oxysterol, N,N-dimethyl-3beta-hydroxycholenamide (DMHCA), represents a gene-selective LXR modulator that mediates potent transcriptional activation of ABCA1 gene expression while exhibiting minimal effects on SREBP-1c both in vitro and in vivo in mice.	Oxysterols	32-41	sterol regulatory element binding transcription factor 1	Mus musculus	241-249
15191540-5	2004	We identified Fra-1 within the AP-1 DNA binding complex by supershift analysis of nuclear extracts from oxysterol-treated, cultured keratinocytes and confirmed that oxysterol treatment increased the levels of Fra-1 by western blot analysis.	Oxysterols	104-113	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	14-19
15148325-7	2004	Both oxysterols inhibited production of Abeta in neurons, but 24(S)-hydroxycholesterol was approximately 1000-fold more potent than 27-hydroxycholesterol.	Oxysterols	5-15	amyloid beta precursor protein	Homo sapiens	40-45
15148325-10	2004	Oxysterols also inhibited protein kinase C activity and APP secretion following stimulation of protein kinase C. The selective expression of CYP46A1 around neuritic plaques and the potent inhibition of APP processing in neurons by 24(S)-hydroxycholesterol suggests that CYP46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease.	Oxysterols	0-10	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	141-148
15148325-10	2004	Oxysterols also inhibited protein kinase C activity and APP secretion following stimulation of protein kinase C. The selective expression of CYP46A1 around neuritic plaques and the potent inhibition of APP processing in neurons by 24(S)-hydroxycholesterol suggests that CYP46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease.	Oxysterols	0-10	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	270-277
15148325-10	2004	Oxysterols also inhibited protein kinase C activity and APP secretion following stimulation of protein kinase C. The selective expression of CYP46A1 around neuritic plaques and the potent inhibition of APP processing in neurons by 24(S)-hydroxycholesterol suggests that CYP46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease.	Oxysterols	0-10	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	270-277
15191540-5	2004	We identified Fra-1 within the AP-1 DNA binding complex by supershift analysis of nuclear extracts from oxysterol-treated, cultured keratinocytes and confirmed that oxysterol treatment increased the levels of Fra-1 by western blot analysis.	Oxysterols	165-174	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	14-19
15191540-5	2004	We identified Fra-1 within the AP-1 DNA binding complex by supershift analysis of nuclear extracts from oxysterol-treated, cultured keratinocytes and confirmed that oxysterol treatment increased the levels of Fra-1 by western blot analysis.	Oxysterols	165-174	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	209-214
15191540-6	2004	Additionally, on Western and Northern analysis, oxysterol treatment increased two other AP-1 proteins, Jun-D and c-Fos, whereas Fra-2, Jun-B, and c-Jun were not changed.	Oxysterols	48-57	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
15191540-6	2004	Additionally, on Western and Northern analysis, oxysterol treatment increased two other AP-1 proteins, Jun-D and c-Fos, whereas Fra-2, Jun-B, and c-Jun were not changed.	Oxysterols	48-57	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118
14992685-10	2004	The oxysterol also inhibited (i) the histamine- and thapsigargin-induced arachidonic acid release, and (ii) the phosphorylation of both cPLA2 and ERK1/2 (extracellular-signal-regulated kinases 1/2).	Oxysterols	4-13	phospholipase A2 group IVA	Homo sapiens	136-141
14992685-10	2004	The oxysterol also inhibited (i) the histamine- and thapsigargin-induced arachidonic acid release, and (ii) the phosphorylation of both cPLA2 and ERK1/2 (extracellular-signal-regulated kinases 1/2).	Oxysterols	4-13	mitogen-activated protein kinase 3	Homo sapiens	146-152
14992685-10	2004	The oxysterol also inhibited (i) the histamine- and thapsigargin-induced arachidonic acid release, and (ii) the phosphorylation of both cPLA2 and ERK1/2 (extracellular-signal-regulated kinases 1/2).	Oxysterols	4-13	mitogen-activated protein kinase 1	Homo sapiens	154-196
14973125-3	2004	Here, we demonstrate a role of 11beta-HSD1 in the metabolism of 7-ketocholesterol (7KC), the major dietary oxysterol.	Oxysterols	107-116	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	31-42
14764421-5	2004	Under steady-state conditions, most of the de novo synthesis of cholesterol in the brain appears to be balanced by excretion of the cytochrome P-450-generated oxysterol 24S-hydroxycholesterol.	Oxysterols	159-168	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	132-148
15171789-7	2004	The stability of Cx43 at the plasma membrane following incubation with oxysterols was evaluated by biotinylation of cell surface proteins.	Oxysterols	71-81	gap junction protein alpha 1	Bos taurus	17-21
14684380-8	2004	When Ch or Ch + CA were fed, hepatic concentrations of oxysterols, ligands for LXR-alpha increased to activate LXR-alpha, as evidenced by increased mRNA levels of ABCA1 and LPL.	Oxysterols	55-65	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	79-88
14684380-8	2004	When Ch or Ch + CA were fed, hepatic concentrations of oxysterols, ligands for LXR-alpha increased to activate LXR-alpha, as evidenced by increased mRNA levels of ABCA1 and LPL.	Oxysterols	55-65	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	111-120
14684380-8	2004	When Ch or Ch + CA were fed, hepatic concentrations of oxysterols, ligands for LXR-alpha increased to activate LXR-alpha, as evidenced by increased mRNA levels of ABCA1 and LPL.	Oxysterols	55-65	ATP binding cassette subfamily A member 1	Rattus norvegicus	163-168
14684380-8	2004	When Ch or Ch + CA were fed, hepatic concentrations of oxysterols, ligands for LXR-alpha increased to activate LXR-alpha, as evidenced by increased mRNA levels of ABCA1 and LPL.	Oxysterols	55-65	lipoprotein lipase	Rattus norvegicus	173-176
15095019-4	2004	We report here on the in vitro oxysterol-metabolizing properties of human and rodent 11beta-HSD1.	Oxysterols	31-40	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	85-96
15072555-4	2004	To investigate whether oxysterols can regulate StAR expression, two steroidogenic cell lines, mouse Y1 adrenocortical and MA-10 Leydig tumor cells, were treated with various oxysterols and steroids, including 25-hydroxycholesterol (25 OHC), 22(R)OHC and 20alphaOHC.	Oxysterols	23-33	steroidogenic acute regulatory protein	Mus musculus	47-51
15072555-5	2004	The majority of these compounds rapidly increased StAR protein levels within as little as 1 h. The most potent oxysterols were 20alphaOHC for Y1 and 25 OHC for MA-10 cells.	Oxysterols	111-121	steroidogenic acute regulatory protein	Mus musculus	50-54
15072555-10	2004	Secondly, through direct conversion to steroid, oxysterols may account in part for StAR-independent steroid production in the body.	Oxysterols	48-58	steroidogenic acute regulatory protein	Mus musculus	83-87
15003524-1	2004	Oxysterol 7alpha-hydroxylase (CYP7B1) metabolizes oxysterols, potent regulators of lipid homeostasis.	Oxysterols	50-60	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-28
15003524-1	2004	Oxysterol 7alpha-hydroxylase (CYP7B1) metabolizes oxysterols, potent regulators of lipid homeostasis.	Oxysterols	50-60	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	30-36
15003524-3	2004	The present results indicate that sterol response element binding protein (SREBP), a family of oxysterol-responsive transcription factors that stimulates cholesterol synthesis, may be an important regulator of CYP7B1.	Oxysterols	95-104	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	210-216
15003524-8	2004	Our findings indicate that CYP7B1 transcription is controlled by SREBP and reveal a link between oxysterol-sensitive regulators and oxysterol metabolism.	Oxysterols	97-106	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	27-33
15003524-8	2004	Our findings indicate that CYP7B1 transcription is controlled by SREBP and reveal a link between oxysterol-sensitive regulators and oxysterol metabolism.	Oxysterols	132-141	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	27-33
15003524-9	2004	We propose that CYP7B1 is important for regulating cellular sterol content and protects against oxysterol-mediated toxicity.	Oxysterols	96-105	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	16-22
14999691-0	2004	Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis.	Oxysterols	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-34
14999691-4	2004	Therefore, we determined if oxysterols modulate COX-2 expression.	Oxysterols	28-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53
14999691-5	2004	The effect of an oxysterol (22(R)-hydroxycholesterol, 22-HC) on COX-2 expression in KMBC cells, a human cholangiocarcinoma cell line, was examined.	Oxysterols	17-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
14999691-7	2004	This oxysterol activated p42/44 and p38 MAPK, but not JNK 1/2.	Oxysterols	5-14	erythrocyte membrane protein band 4.2	Homo sapiens	25-28
14999691-7	2004	This oxysterol activated p42/44 and p38 MAPK, but not JNK 1/2.	Oxysterols	5-14	mitogen-activated protein kinase 14	Homo sapiens	36-39
14999691-12	2004	This enhanced COX-2 protein expression by oxysterols may participate in the genesis and progression of cholangiocarcinoma.	Oxysterols	42-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
14769039-3	2004	Cholesterol- and oxysterol-mediated up-regulation of ABCA1 transcription includes the binding of the liver X receptor and retinoid X receptor (LXR/RXR) heterodimer to the DR-4 element of the ABCA1 promoter.	Oxysterols	17-26	ATP binding cassette subfamily A member 1	Homo sapiens	53-58
15120425-7	2004	Oxysterol-resistant cells demonstrated no significant difference in the expression of several genes previously implicated in oxysterol resistance, but expressed the bcl-2 gene at significantly lower levels than those observed in control cells.	Oxysterols	0-9	BCL2 apoptosis regulator	Homo sapiens	165-170
14769039-3	2004	Cholesterol- and oxysterol-mediated up-regulation of ABCA1 transcription includes the binding of the liver X receptor and retinoid X receptor (LXR/RXR) heterodimer to the DR-4 element of the ABCA1 promoter.	Oxysterols	17-26	retinoid X receptor alpha	Homo sapiens	147-150
14769039-3	2004	Cholesterol- and oxysterol-mediated up-regulation of ABCA1 transcription includes the binding of the liver X receptor and retinoid X receptor (LXR/RXR) heterodimer to the DR-4 element of the ABCA1 promoter.	Oxysterols	17-26	ATP binding cassette subfamily A member 1	Homo sapiens	191-196
14559920-0	2004	AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis.	Oxysterols	61-70	thymoma viral proto-oncogene 1	Mus musculus	0-3
15052330-1	2004	Oxysterols are potent signalling lipids that directly bind liver X receptors (LXRs) and a subset of oxysterol binding protein (OSBP) related proteins (ORPs).	Oxysterols	0-10	oxysterol binding protein	Homo sapiens	100-125
15052330-1	2004	Oxysterols are potent signalling lipids that directly bind liver X receptors (LXRs) and a subset of oxysterol binding protein (OSBP) related proteins (ORPs).	Oxysterols	0-10	oxysterol binding protein	Homo sapiens	127-131
15051324-7	2004	With the aim to investigate the mechanisms underlying the quenching of 7K-dependent apoptosis by the oxysterol mixture, we found that the combined oxysterol mixture counteracted the ability of 7K given alone to strongly increase the steady-state level of reactive oxygen species (ROS) in macrophages as well as the up-regulation of the pro-apoptotic factor p21 and the triggering of the mitochondria-dependent pathway of apoptosis.	Oxysterols	147-156	H3 histone pseudogene 16	Homo sapiens	357-360
14559920-4	2004	In this study, we demonstrate that, in the murine macrophage-like cell line P388D1, oxysterols (25-hydroxycholesterol and 7-ketocholesterol) induced the degradation of the prosurvival protein kinase AKT (protein kinase B).	Oxysterols	84-94	thymoma viral proto-oncogene 1	Mus musculus	199-202
14559920-6	2004	These responses would be expected to activate the pro-apoptotic multi-BCL homology domain proteins BAX and BAK, leading to the previously reported release of cytochrome c observed during oxysterol-induced apoptosis.	Oxysterols	187-196	BCL2-associated X protein	Mus musculus	99-102
14559920-6	2004	These responses would be expected to activate the pro-apoptotic multi-BCL homology domain proteins BAX and BAK, leading to the previously reported release of cytochrome c observed during oxysterol-induced apoptosis.	Oxysterols	187-196	BCL2-antagonist/killer 1	Mus musculus	107-110
14681840-2	2004	The aim of the current study was to ascertain whether the level of this oxysterol reflects hepatic cholesterol 7alpha-hydroxylase activity when plasma cholesterol concentrations are markedly changed.	Oxysterols	72-81	cytochrome P450 7A1	Oryctolagus cuniculus	99-129
14994280-2	2004	Though not fully elucidated, the mechanism through which this oxysterol induces cell death is thought to involve the generation of an oxidative stress leading to perturbation of the mitochondrion and release of cytochrome c into the cytosol.	Oxysterols	62-71	cytochrome c, somatic	Homo sapiens	211-223
14512442-0	2003	Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation.	Oxysterols	26-35	lanosterol synthase	Homo sapiens	94-130
12882648-12	2003	Finally, we have demonstrated that oxysterols act independent of interleukin-1beta and cAMP pathways to activate the sPLA(2) promoter.	Oxysterols	35-45	phospholipase A2 group IIA	Rattus norvegicus	117-124
14690017-11	2003	Clofibrate increases cytochrome P450 content and the resulting oxysterol generation may partly mediate the clofibrate-induced up-regulattion of LXRa and ABCA1, which are related to reverse cholesterol transport.	Oxysterols	63-72	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	144-148
14690017-11	2003	Clofibrate increases cytochrome P450 content and the resulting oxysterol generation may partly mediate the clofibrate-induced up-regulattion of LXRa and ABCA1, which are related to reverse cholesterol transport.	Oxysterols	63-72	ATP binding cassette subfamily A member 1	Rattus norvegicus	153-158
14512442-3	2003	It is known that addition of exogenous oxysterols to cultured macrophages activates LXR, leading to increased expression of ABCA1 and cholesterol efflux.	Oxysterols	39-49	ATP binding cassette subfamily A member 1	Homo sapiens	124-129
14512442-5	2003	Macrophage synthesis of 24(S),25-epoxycholesterol, a potent LXR ligand, increased 60-fold by partial inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), a microsomal enzyme in both the cholesterol biosynthetic pathway and the alternative oxysterol synthetic pathway.	Oxysterols	244-253	lanosterol synthase	Homo sapiens	115-151
14512442-5	2003	Macrophage synthesis of 24(S),25-epoxycholesterol, a potent LXR ligand, increased 60-fold by partial inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), a microsomal enzyme in both the cholesterol biosynthetic pathway and the alternative oxysterol synthetic pathway.	Oxysterols	244-253	lanosterol synthase	Homo sapiens	153-156
14551533-4	2003	The expression of the differentiation marker p57KIP2, proliferation marker PCNA (Proliferating Cell Nuclear Antigen) and fibers specific proteins gamma-crystallin, CP49, MIP26 following treatment with oxysterols was determined by western blot.	Oxysterols	201-211	major intrinsic protein of lens fiber	Homo sapiens	170-175
14612204-3	2003	The aim of this study was to investigate the effect of hypoxia on the secretion of IL-8 by oxysterol-stimulated macrophages.	Oxysterols	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
14612204-9	2003	Thus, hypoxia in atherosclerotic plaques may increase the secretion of IL-8 from oxysterol-containing foam cells, which subsequently may accelerate the progression of atherosclerosis.	Oxysterols	81-90	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
12897188-3	2003	In contrast, the mRNA levels of the LXRalpha target genes ATP binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) increased 5-fold and 2.3-fold, respectively, associated with significant increases in hepatic concentrations of oxysterols.	Oxysterols	260-270	oxysterols receptor LXR-alpha	Oryctolagus cuniculus	36-44
12897188-3	2003	In contrast, the mRNA levels of the LXRalpha target genes ATP binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) increased 5-fold and 2.3-fold, respectively, associated with significant increases in hepatic concentrations of oxysterols.	Oxysterols	260-270	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	58-93
12897188-3	2003	In contrast, the mRNA levels of the LXRalpha target genes ATP binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) increased 5-fold and 2.3-fold, respectively, associated with significant increases in hepatic concentrations of oxysterols.	Oxysterols	260-270	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	95-100
12897188-3	2003	In contrast, the mRNA levels of the LXRalpha target genes ATP binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) increased 5-fold and 2.3-fold, respectively, associated with significant increases in hepatic concentrations of oxysterols.	Oxysterols	260-270	cholesteryl ester transfer protein	Oryctolagus cuniculus	106-140
12897188-3	2003	In contrast, the mRNA levels of the LXRalpha target genes ATP binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) increased 5-fold and 2.3-fold, respectively, associated with significant increases in hepatic concentrations of oxysterols.	Oxysterols	260-270	cholesteryl ester transfer protein	Oryctolagus cuniculus	142-146
12719428-6	2003	Moreover, we demonstrate that treatment with oxysterols reduces cholesterol in NPC mutants and is able to correct the NPC1I1061T phenotype, the most prevalent NPC1 disease genotype.	Oxysterols	45-55	NPC intracellular cholesterol transporter 1	Homo sapiens	118-122
12734199-7	2003	In MCF-7 cells, OS increases the intracellular concentration of sphingomyelin and other phospholipids and induces the translocation of the small GTPase p21Ras to GM1- and cholesterol-rich membrane areas.	Oxysterols	16-18	HRas proto-oncogene, GTPase	Homo sapiens	152-158
12547833-6	2003	The basal ABCA1 mRNA and protein levels detected in these cell types were increased markedly after exposure to oxysterols and 9-cis-retinoic acid, which are ligands for the nuclear hormone liver X receptors and retinoic X receptors, respectively.	Oxysterols	111-121	ATP binding cassette subfamily A member 1	Rattus norvegicus	10-15
12876624-3	2003	In this study we demonstrate that oxysterols, which participate in maintaining cholesterol homeostasis, also down regulate fibrinogen expression.	Oxysterols	34-44	fibrinogen beta chain	Homo sapiens	123-133
12876624-5	2003	The inhibition of fibrinogen synthesis by oxysterols was maintained in interleukin-6 treated cells.	Oxysterols	42-52	fibrinogen beta chain	Homo sapiens	18-28
12876624-5	2003	The inhibition of fibrinogen synthesis by oxysterols was maintained in interleukin-6 treated cells.	Oxysterols	42-52	interleukin 6	Homo sapiens	71-84
12876624-6	2003	Other oxysterols, that inhibit cholesterol synthesis by a feedback mechanism, also diminished fibrinogen expression in HepG2, rat H-4-II-E hepatoma cells and in primary human hepatocytes.	Oxysterols	6-16	fibrinogen beta chain	Homo sapiens	94-104
12706121-6	2003	Interestingly, while the presence of oxysterols in cell membranes significantly inhibits chemokine receptor function, this inhibitory effect does not involve alterations in receptor conformation, expression, or a direct antagonism of chemokine binding.	Oxysterols	37-47	C-X-C motif chemokine receptor 4	Homo sapiens	89-107
12706121-7	2003	We propose here a novel mechanism for oxysterol-mediated inhibition of chemokine receptor function and the implications for the presence of oxysterols on immune cells.	Oxysterols	38-47	C-X-C motif chemokine receptor 4	Homo sapiens	71-89
12488438-2	2003	In adult animals, insulin and oxysterols induce SREBP-1c gene transcription, whereas polyunsaturated fatty acids suppress the nuclear content of SREBP-1c through pre-translational regulatory mechanisms.	Oxysterols	30-40	sterol regulatory element binding transcription factor 1	Rattus norvegicus	48-56
12704471-1	2003	The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol catabolism to bile acids and feedback repression of bile acid synthesis, respectively.	Oxysterols	102-111	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	75-85
12704471-1	2003	The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol catabolism to bile acids and feedback repression of bile acid synthesis, respectively.	Oxysterols	102-111	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	134-144
12704471-1	2003	The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol catabolism to bile acids and feedback repression of bile acid synthesis, respectively.	Oxysterols	102-111	nuclear receptor subfamily 1 group H member 4	Homo sapiens	146-149
12633677-1	2003	The liver X receptors (LXRalpha and LXRbeta) are nuclear receptor transcription factors that are activated by certain oxysterol derivatives of cholesterol.	Oxysterols	118-127	nuclear receptor subfamily 1 group H member 3	Homo sapiens	23-31
12633677-1	2003	The liver X receptors (LXRalpha and LXRbeta) are nuclear receptor transcription factors that are activated by certain oxysterol derivatives of cholesterol.	Oxysterols	118-127	nuclear receptor subfamily 1 group H member 2	Homo sapiens	36-43
12554795-1	2003	In rodent liver, transcription of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the rate-limiting step in the classic bile acid synthetic pathway, is stimulated by the liver X receptor alpha (LXRalpha), a nuclear receptor for oxysterol metabolites of cholesterol.	Oxysterols	255-264	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	52-82
12554795-1	2003	In rodent liver, transcription of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the rate-limiting step in the classic bile acid synthetic pathway, is stimulated by the liver X receptor alpha (LXRalpha), a nuclear receptor for oxysterol metabolites of cholesterol.	Oxysterols	255-264	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	84-90
12554795-1	2003	In rodent liver, transcription of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the rate-limiting step in the classic bile acid synthetic pathway, is stimulated by the liver X receptor alpha (LXRalpha), a nuclear receptor for oxysterol metabolites of cholesterol.	Oxysterols	255-264	nuclear receptor subfamily 1 group H member 3	Homo sapiens	221-229
12527036-0	2003	Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line.	Oxysterols	0-10	GLI family zinc finger 2	Homo sapiens	98-103
12527036-2	2003	Among the tested cell lines, both oxysterols showed the highest cytotoxicity to THP-1, human monocytic leukemia cell line.	Oxysterols	34-44	GLI family zinc finger 2	Homo sapiens	80-85
12470667-0	2002	Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes.	Oxysterols	0-9	nuclear receptor subfamily 1 group H member 3	Homo sapiens	20-28
12542530-10	2003	Finally, immunohistochemistry demonstrated an inhibition in the production of the pro-inflammatory cytokines interleukin-1alpha and tumor necrosis factor alpha in the oxysterol-treated sites from both TPA- and oxazolone-treated animals.	Oxysterols	167-176	interleukin 1 alpha	Mus musculus	109-127
12542530-10	2003	Finally, immunohistochemistry demonstrated an inhibition in the production of the pro-inflammatory cytokines interleukin-1alpha and tumor necrosis factor alpha in the oxysterol-treated sites from both TPA- and oxazolone-treated animals.	Oxysterols	167-176	tumor necrosis factor	Mus musculus	132-159
12470667-0	2002	Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes.	Oxysterols	0-9	retinoid X receptor alpha	Homo sapiens	29-32
12470667-0	2002	Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes.	Oxysterols	0-9	HSR	Homo sapiens	41-44
12242342-1	2002	Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR; cholesterol-lowering)- and sterol regulatory element-binding protein (SREBP; cholesterol-raising)-mediated signaling pathways.	Oxysterols	0-10	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	102-143
12161442-9	2002	Functional assays showed that 22:4,n6 was approximately 2-fold more effective than 20:4,n6 at inhibiting oxysterol-induced LXRalpha activity in HEK293-E cells, but had no effect on LXRalpha activity in HEK293-L cells.	Oxysterols	105-114	nuclear receptor subfamily 1 group H member 3	Homo sapiens	123-131
12384498-6	2002	ABCA1 was induced by treatment with retinoic acid and several oxysterols, including 22(R)-hydroxycholesterol and 24-hydroxycholesterol.	Oxysterols	62-72	ATP binding cassette subfamily A member 1	Rattus norvegicus	0-5
12242342-1	2002	Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR; cholesterol-lowering)- and sterol regulatory element-binding protein (SREBP; cholesterol-raising)-mediated signaling pathways.	Oxysterols	0-10	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	145-150
12242342-2	2002	Previously we reported that the hypocholesterolemic agent LY295427 (4alpha-allylcholestan-3alpha-ol) reverses oxysterol-mediated suppression of SREBP processing.	Oxysterols	110-119	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	144-149
12242342-3	2002	We now report that LY295427 increases expression of insulin-induced gene-1 (INSIG-1) and restores SREBP processing in cells treated with oxysterols.	Oxysterols	137-147	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	98-103
12085989-8	2002	Our data suggested that the chronic exposure of hepatocytes and macrophage cells to high concentration of cholesterol or oxysterols may induce iNOS expression and subsequent synthesis of NO, which may be important in the pathogenesis of atherosclerosis.	Oxysterols	121-131	nitric oxide synthase 2, inducible	Mus musculus	143-147
12202460-5	2002	Oxysterols activate the liver orphan receptors (LXR) to induce cholesterol 7alpha-hydroxylase and ATP-binding cassette family of transporters and thus promote reverse cholesterol transport from the peripheral tissues to the liver for degradation to bile acids.	Oxysterols	0-10	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	63-93
12135663-5	2002	Similarly, the effect of oxysterols on HL60 and CD34+ cells was investigated using annexin V staining and flow cytometry to measure apoptosis.	Oxysterols	25-35	CD34 molecule	Homo sapiens	48-52
12135663-9	2002	Oxysterol treatment of HL60 cells inhibited cell growth and increased the number of annexin V+ and nitroblue tetrazolium+ cells.	Oxysterols	0-9	annexin A5	Homo sapiens	84-93
12135663-10	2002	The percentage of viable, CD34+ annexin V+ cells also was increased with oxysterol treatment of purified HPCs in liquid culture.	Oxysterols	73-82	CD34 molecule	Homo sapiens	26-30
12135663-10	2002	The percentage of viable, CD34+ annexin V+ cells also was increased with oxysterol treatment of purified HPCs in liquid culture.	Oxysterols	73-82	annexin A5	Homo sapiens	32-41
11884587-0	2002	Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis.	Oxysterols	67-76	signal transducer and activator of transcription 1	Homo sapiens	0-5
12056586-9	2002	Apolipoprotein (apo) analysis showed that oxysterol incorporation reduced the apoE content and altered the apoC phenotype of chylomicrons, which may have an impact on the removal of chylomicron remnants from plasma.	Oxysterols	42-51	apolipoprotein E	Rattus norvegicus	78-82
11884587-0	2002	Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis.	Oxysterols	67-76	tumor protein p53	Homo sapiens	17-20
11884587-0	2002	Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis.	Oxysterols	67-76	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-50
11884587-0	2002	Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis.	Oxysterols	67-76	cyclin dependent kinase inhibitor 1A	Homo sapiens	51-55
11802775-1	2002	Oxysterol-binding protein (OSBP) is the prototypical member of a class of phospholipid and oxysterol-binding proteins that interacts with the Golgi apparatus and regulates lipid and cholesterol metabolism.	Oxysterols	91-100	oxysterol binding protein	Homo sapiens	0-25
12449021-3	2002	LXR/RXR heterodimers function as sensors for cellular oxysterols and, when activated by these agonists, increase the expression of genes that control sterol and fatty acid metabolism/homeostasis.	Oxysterols	54-64	nuclear receptor subfamily 1, group H, member 3	Mus musculus	0-3
11741944-0	2002	Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes.	Oxysterols	0-9	tumor necrosis factor	Homo sapiens	124-151
11741944-1	2002	Liver X receptor alpha (LXRalpha), is a nuclear hormone receptor that is activated by oxysterols and plays a crucial role in regulating cholesterol and lipid metabolism in liver and cholesterol efflux from lipid-loaded macrophages.	Oxysterols	86-96	nuclear receptor subfamily 1 group H member 3	Homo sapiens	24-32
11802775-1	2002	Oxysterol-binding protein (OSBP) is the prototypical member of a class of phospholipid and oxysterol-binding proteins that interacts with the Golgi apparatus and regulates lipid and cholesterol metabolism.	Oxysterols	91-100	oxysterol binding protein	Homo sapiens	27-31
11851725-0	2002	Oxysterols induce interleukin-1beta production in human macrophages.	Oxysterols	0-10	interleukin 1 beta	Homo sapiens	18-35
11755924-0	2002	Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E.	Oxysterols	0-9	apolipoprotein E	Mus musculus	120-136
11641412-2	2001	Expression of ABCA1 may be increased by certain oxysterols such as 22(R)-hydroxycholesterol via activation of the nuclear hormone receptor liver X receptor (LXR).	Oxysterols	48-58	ATP binding cassette subfamily A member 1	Homo sapiens	14-19
11851872-0	2002	Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.	Oxysterols	0-9	nuclear receptor subfamily 1, group H, member 2	Mus musculus	66-87
11851872-5	2002	Moreover, oxysterol treatment increased the levels of involucrin, loricrin, and profilaggrin protein and mRNA in the epidermis, indicating that oxysterols stimulate epidermal differentiation.	Oxysterols	10-19	loricrin	Mus musculus	66-74
11851872-5	2002	Moreover, oxysterol treatment increased the levels of involucrin, loricrin, and profilaggrin protein and mRNA in the epidermis, indicating that oxysterols stimulate epidermal differentiation.	Oxysterols	10-19	filaggrin	Mus musculus	80-92
11851872-8	2002	Topical oxysterol treatment induced differentiation in liver X receptor-alpha-/- mice whereas in liver X receptor-beta-/- mice there was no increase in the expression of differentiation markers.	Oxysterols	8-17	nuclear receptor subfamily 1, group H, member 3	Mus musculus	55-77
11577112-2	2001	Here we trace the hypocholesterolemic activity of LY295427 to an ability to reverse oxysterol-mediated suppression of sterol regulatory element-binding protein (SREBP) processing.	Oxysterols	84-93	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	118-159
11577112-2	2001	Here we trace the hypocholesterolemic activity of LY295427 to an ability to reverse oxysterol-mediated suppression of sterol regulatory element-binding protein (SREBP) processing.	Oxysterols	84-93	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	161-166
11577112-7	2001	LY295427 overcame the suppression of SREBP processing mediated by several oxysterols but not by LDL-derived cholesterol.	Oxysterols	74-84	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	37-42
11669638-1	2001	Cholesterol removal from lipid-loaded macrophages is an important, potentially antiatherogenic process, and we have previously shown that an oxysterol, 7-ketocholesterol (7K), can impair efflux to lipid-free apoprotein A-1 (apoA-1).	Oxysterols	141-150	apolipoprotein A1	Homo sapiens	224-230
11546778-7	2001	We conclude that LXRalpha regulates its own expression in human macrophages and that this response is likely to amplify the effects of oxysterols on reverse cholesterol transport.	Oxysterols	135-145	nuclear receptor subfamily 1 group H member 3	Homo sapiens	17-25
11689206-2	2001	We have examined the interaction of recombinant His-tagged caveolin-1 with cholesterol and 7-keto cholesterol, the most abundant non-enzymatically formed oxysterol found in oxidised LDL and atheromatous plaque.	Oxysterols	154-163	caveolin 1	Homo sapiens	59-69
11606068-1	2001	Here we report the induction of gene expression of ABCG4, a member of the ABC transporter subfamily G, from human macrophages by oxysterols and retinoids, agonists of the nuclear receptors LXR and RXR.	Oxysterols	129-139	ATP binding cassette subfamily G member 4	Homo sapiens	51-56
11606068-1	2001	Here we report the induction of gene expression of ABCG4, a member of the ABC transporter subfamily G, from human macrophages by oxysterols and retinoids, agonists of the nuclear receptors LXR and RXR.	Oxysterols	129-139	retinoid X receptor alpha	Homo sapiens	197-200
11397693-10	2001	Oxysterols and bile acids may also act via the ligand-activated nuclear receptors LXR and FXR to link the metabolic pathways controlling energy balance and lipid metabolism to nutritional state.	Oxysterols	0-10	nuclear receptor subfamily 1, group H, member 3	Mus musculus	82-85
11500512-4	2001	Northern analysis using exon-specific probes confirms that oxysterol treatment results in &gt;10-fold induction of ABCG1 transcripts that are derived from either exons 8-23 or exons 5, 7, and 11-23.	Oxysterols	59-68	ATP binding cassette subfamily G member 1	Homo sapiens	115-120
11568019-6	2001	The ORP-3 predicted protein contains an oxysterol-binding domain.	Oxysterols	40-49	oxysterol binding protein like 3	Homo sapiens	4-9
11568019-9	2001	Characterization and differential expression of ORP-3 implicates a possible role in the mediation of oxysterol effects on hematopoiesis.	Oxysterols	101-110	oxysterol binding protein like 3	Homo sapiens	48-53
11500175-3	2001	In this study we have investigated the effect of four different oxysterols on an LPS-induced TNF-alpha secretion in human macrophages.	Oxysterols	64-74	interferon regulatory factor 6	Homo sapiens	81-84
11500175-3	2001	In this study we have investigated the effect of four different oxysterols on an LPS-induced TNF-alpha secretion in human macrophages.	Oxysterols	64-74	tumor necrosis factor	Homo sapiens	93-102
11470525-1	2001	Oxysterol 7 alpha-hydroxylase catalyzes hydroxylation of oxysterols and neurosterols and plays a role in the alternative bile acid synthesis pathway.	Oxysterols	57-67	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-29
11470525-8	2001	Thus, regulation of CYP7B1 transcription by Sp1 may play a pivotal role in regulating oxysterol levels, which regulate cholesterol metabolism.	Oxysterols	86-95	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	20-26
11416019-9	2001	HST1 preferentially sulfonated DHEA and, to a lesser extent, oxysterols; whereas cholesterol was a negligible substrate.	Oxysterols	61-71	fibroblast growth factor 4	Homo sapiens	0-4
11416019-10	2001	The reverse, however, was the case for the HST2 isoforms, particularly HST2b, which preferentially sulfonated cholesterol and oxysterols, in contrast to DHEA, which served as a poor substrate for this enzyme.	Oxysterols	126-136	fibroblast growth factor 6	Homo sapiens	43-47
11521968-0	2001	Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells.	Oxysterols	17-26	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	50-71
11514559-2	2001	These oxysterols are formed from cholesterol by specific cytochrome P450 enzymes, CYP27, CYP46, and CYP7A, respectively.	Oxysterols	6-16	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	82-87
11514559-2	2001	These oxysterols are formed from cholesterol by specific cytochrome P450 enzymes, CYP27, CYP46, and CYP7A, respectively.	Oxysterols	6-16	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	89-94
11521968-11	2001	This is the first study to demonstrate that sterol 27-hydroxylase plays an important role in the metabolism of oxysterols such as 7K in liver cells.	Oxysterols	111-121	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	44-65
11397693-10	2001	Oxysterols and bile acids may also act via the ligand-activated nuclear receptors LXR and FXR to link the metabolic pathways controlling energy balance and lipid metabolism to nutritional state.	Oxysterols	0-10	nuclear receptor subfamily 1, group H, member 4	Mus musculus	90-93
11284740-14	2001	Moreover, RNA analysis (reverse-transcription PCR, Northern blotting and in situ hybridization) revealed a high expression of cyp7b1 mRNA in the rat prostate, restricted to the epithelium, suggesting that cyp7b1 catalyses oxysterol 7alpha-hydroxylation in the prostate gland.	Oxysterols	222-231	cytochrome P450 family 7 subfamily B member 1	Rattus norvegicus	126-132
11408574-1	2001	Oxysterol binding protein (OSBP) is the only protein known to bind specifically to the group of oxysterols with potent effects on cholesterol homeostasis.	Oxysterols	96-106	oxysterol binding protein	Homo sapiens	27-31
11325610-8	2001	Adherence of mononuclear cells to TNF-stimulated HUVEC monolayers was slightly inhibited by 7-ketocholesterol, but this oxysterol did not affect the basal adherence to non-stimulated HUVECs.	Oxysterols	120-129	tumor necrosis factor	Homo sapiens	34-37
11284740-14	2001	Moreover, RNA analysis (reverse-transcription PCR, Northern blotting and in situ hybridization) revealed a high expression of cyp7b1 mRNA in the rat prostate, restricted to the epithelium, suggesting that cyp7b1 catalyses oxysterol 7alpha-hydroxylation in the prostate gland.	Oxysterols	222-231	cytochrome P450 family 7 subfamily B member 1	Rattus norvegicus	205-211
11171976-5	2001	These data suggest that transcription of the SREBP-1c gene in hepatocytes requires tonic activation of LXR by an oxysterol intermediate in the cholesterol biosynthetic pathway.	Oxysterols	113-122	sterol regulatory element binding transcription factor 1	Rattus norvegicus	45-53
11238557-1	2001	The nuclear oxysterol-receptor paralogues LXRalpha and LXRbeta share a high degree of amino acid identity and bind endogenous oxysterol ligands with similar affinities.	Oxysterols	12-21	nuclear receptor subfamily 1, group H, member 3	Mus musculus	42-50
11238557-1	2001	The nuclear oxysterol-receptor paralogues LXRalpha and LXRbeta share a high degree of amino acid identity and bind endogenous oxysterol ligands with similar affinities.	Oxysterols	12-21	nuclear receptor subfamily 1, group H, member 2	Mus musculus	55-62
11300870-7	2001	Site-directed mutagenesis identified Trp(443) as an amino acid critical for activation of LXRalpha by oxysterol ligands.	Oxysterols	102-111	nuclear receptor subfamily 1 group H member 3	Homo sapiens	90-98
11231926-6	2001	Oxysterols (7beta-hydroxycholesterol, 7-ketocholesterol, and cholesterol-5,6-epoxides), which are assumed to be the most toxic constituents of oxidized LDL, induced apoptosis in HAECs through calcium mobilization followed by activation of caspase-3.	Oxysterols	0-10	caspase 3	Homo sapiens	239-248
11231926-7	2001	Ethanol, methanol, isopropanol, tert-butanol, and red wine all potentiated oxysterol-induced cell death up to 5-fold, paralleled by further induction of caspase-3.	Oxysterols	75-84	caspase 3	Homo sapiens	153-162
10882719-7	2000	A partially purified and reconstituted cholesterol 7 alpha-hydroxylase enzyme fraction from pig liver showed 7 alpha-hydroxylase activity toward the same oxysterols as metabolized by expressed recombinant human and rat CYP7A.	Oxysterols	154-164	cytochrome P450 family 7 subfamily A member 1	Sus scrofa	39-70
11179691-4	2001	Cotransfection with LXRalpha and RXRalpha expression plasmids strongly stimulated rat CYP7A1/luciferase reporter activity in HepG2 cells and oxysterol was not required.	Oxysterols	141-150	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	20-28
11179691-4	2001	Cotransfection with LXRalpha and RXRalpha expression plasmids strongly stimulated rat CYP7A1/luciferase reporter activity in HepG2 cells and oxysterol was not required.	Oxysterols	141-150	retinoid X receptor alpha	Rattus norvegicus	33-41
11095949-3	2000	Oxysterol-induced apoptosis in CHO-K1 was accompanied by caspase activation and was preceded by mitochondrial cytochrome c release.	Oxysterols	0-9	cytochrome c	Cricetulus griseus	110-122
11090131-1	2000	The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and subsequent gene targeting studies in mice provided strong evidence that LXR plays a central role in cholesterol metabolism.	Oxysterols	17-27	nuclear receptor subfamily 1, group H, member 3	Mus musculus	46-62
11090131-1	2000	The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and subsequent gene targeting studies in mice provided strong evidence that LXR plays a central role in cholesterol metabolism.	Oxysterols	17-27	nuclear receptor subfamily 1, group H, member 3	Mus musculus	64-67
11090131-1	2000	The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and subsequent gene targeting studies in mice provided strong evidence that LXR plays a central role in cholesterol metabolism.	Oxysterols	17-27	nuclear receptor subfamily 1, group H, member 3	Mus musculus	153-156
11058697-6	2000	Addition of TNFalpha (10 ng/ml) and IFNgamma (20 ng/ml) enhanced the cytotoxicity of oxysterols and potentiated apoptosis.	Oxysterols	85-95	tumor necrosis factor	Homo sapiens	12-20
11058697-6	2000	Addition of TNFalpha (10 ng/ml) and IFNgamma (20 ng/ml) enhanced the cytotoxicity of oxysterols and potentiated apoptosis.	Oxysterols	85-95	interferon gamma	Homo sapiens	36-44
11233743-0	2001	Confocal analysis of phosphatidylserine externalization with the use of biotinylated annexin V revealed with streptavidin-FITC, -europium, -phycoerythrin or -Texas Red in oxysterol-treated apoptotic cells.	Oxysterols	171-180	annexin A5	Homo sapiens	85-94
11030331-1	2000	The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of the pathway"s rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1).	Oxysterols	62-72	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	165-195
11035776-3	2000	We demonstrate that retroviral expression of LXR alpha in NIH 3T3 fibroblasts or RAW264.7 macrophages and/or treatment of these cells with oxysterol ligands of LXR results in 7- to 30-fold induction of the mRNA encoding the putative cholesterol/phospholipid transporter ATP-binding cassette (ABC)A1.	Oxysterols	139-148	nuclear receptor subfamily 1 group H member 3	Homo sapiens	45-54
11035776-3	2000	We demonstrate that retroviral expression of LXR alpha in NIH 3T3 fibroblasts or RAW264.7 macrophages and/or treatment of these cells with oxysterol ligands of LXR results in 7- to 30-fold induction of the mRNA encoding the putative cholesterol/phospholipid transporter ATP-binding cassette (ABC)A1.	Oxysterols	139-148	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	292-295
11035776-5	2000	We further demonstrate that expression of LXR alpha in NIH 3T3 fibroblasts and/or treatment of these cells with oxysterols is sufficient to stimulate cholesterol efflux to extracellular apolipoprotein AI.	Oxysterols	112-122	apolipoprotein A1	Homo sapiens	186-203
10869358-8	2000	Sterol 27-hydroxylase therefore appears to represent an important pathway by which macrophages eliminate not only cholesterol but also oxysterols such as 7K.	Oxysterols	135-145	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-21
11030331-1	2000	The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of the pathway"s rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1).	Oxysterols	62-72	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	197-203
10933125-6	2000	Importantly, the effects of oxysterols, such as 7-ketocholesterol (7KC), on cholesterol and other lipid efflux by apoA-I needs to be investigated in any attempt to utilise apoA-I as an agent to stimulate efflux of lipids.	Oxysterols	28-38	apolipoprotein A1	Homo sapiens	114-120
10938412-11	2000	In our previous study, we found that oxLDL also contained high levels of oxysterols and thiobarbituric acid reactive substances (TBARS), which enhanced platelet reactivity to thrombin and increased TXA(2) release.	Oxysterols	73-83	coagulation factor II, thrombin	Homo sapiens	175-183
10748047-1	2000	The synthesis of 7alpha-hydroxylated bile acids from oxysterols requires an oxysterol 7alpha-hydroxylase encoded by the Cyp7b1 locus.	Oxysterols	53-63	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	76-104
10751394-10	2000	Finally, we showed that the lysosomal cholesterol pool in NP-C cells was substantially and preferentially reduced by incubating cells with the oxysterols, 25-hydroxycholesterol and 7-ketocholesterol; these findings suggest a new pharmacological approach to the treatment of NP-C disease.	Oxysterols	143-153	NPC intracellular cholesterol transporter 1	Homo sapiens	58-62
10748048-3	2000	Plasma and tissue levels of 25- and 27-hydroxycholesterol, two oxysterol substrates of this enzyme with potent regulatory actions in cultured cells, were markedly elevated in Cyp7b1(-/-) knockout animals.	Oxysterols	63-72	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	175-181
10748047-1	2000	The synthesis of 7alpha-hydroxylated bile acids from oxysterols requires an oxysterol 7alpha-hydroxylase encoded by the Cyp7b1 locus.	Oxysterols	53-63	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	120-126
10720491-0	2000	Oxidized monocyte-derived macrophages in aortic atherosclerotic lesion from apolipoprotein E-deficient mice and from human carotid artery contain lipid peroxides and oxysterols.	Oxysterols	166-176	apolipoprotein E	Mus musculus	76-92
10799558-7	2000	Furthermore, the oxysterol-mediated induction of ABC8 expression in mouse peritoneal macrophages was dependent on the presence of the nuclear oxysterol receptors, liver X receptors (LXRs).	Oxysterols	17-26	ATP binding cassette subfamily G member 1	Mus musculus	49-53
10799558-9	2000	Oxysterol-dependent induction of white/ABC8 mRNA was blocked by actinomycin D but not by cycloheximide treatment of cells.	Oxysterols	0-9	ATP binding cassette subfamily G member 1	Homo sapiens	39-43
10462436-4	1999	Two other nuclear receptors, designated LXR and FXR, which are respectively activated by oxysterols and bile acids, also play a role in liver P450 expression, in this case regulation of P450 cholesterol 7alpha-hydroxylase, a key enzyme of bile acid biosynthesis.	Oxysterols	89-99	nuclear receptor subfamily 1 group H member 4	Homo sapiens	48-51
10692116-10	2000	Either deletion of the -2452 bp to -1880 bp region of the involucrin promoter, or mutation of the AP-1 site within this region, abolished oxysterol responsiveness.	Oxysterols	138-147	involucrin	Homo sapiens	58-68
10692116-10	2000	Either deletion of the -2452 bp to -1880 bp region of the involucrin promoter, or mutation of the AP-1 site within this region, abolished oxysterol responsiveness.	Oxysterols	138-147	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102
10692116-11	2000	Moreover, increased AP-1 DNA binding was observed in oxysterol-treated keratinocytes by gel shift analyses.	Oxysterols	53-62	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-24
10692116-13	2000	These data suggest that oxysterols induce keratinocyte differentiation, in part through increased AP-1-dependent transcription of the involucrin gene, an effect that may be mediated by liver X-activated receptor.	Oxysterols	24-34	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102
10692116-13	2000	These data suggest that oxysterols induce keratinocyte differentiation, in part through increased AP-1-dependent transcription of the involucrin gene, an effect that may be mediated by liver X-activated receptor.	Oxysterols	24-34	involucrin	Homo sapiens	134-144
10783008-3	2000	Growth studies based on dye exclusion by viable cells while using a sublethal concentration of oxysterols ranked their potency for cell kill as 25OHC &gt; K15 &gt; CK15 &gt; CK7.	Oxysterols	95-105	keratin 15	Homo sapiens	155-158
10783008-3	2000	Growth studies based on dye exclusion by viable cells while using a sublethal concentration of oxysterols ranked their potency for cell kill as 25OHC &gt; K15 &gt; CK15 &gt; CK7.	Oxysterols	95-105	keratin 15	Homo sapiens	164-168
10783008-3	2000	Growth studies based on dye exclusion by viable cells while using a sublethal concentration of oxysterols ranked their potency for cell kill as 25OHC &gt; K15 &gt; CK15 &gt; CK7.	Oxysterols	95-105	keratin 7	Homo sapiens	174-177
10675617-2	2000	Recent findings led to the suggestion that some of these functions are mediated by the nuclear receptors LXRalpha and LXRbeta owing to their potential to bind a group of naturally occurring oxysterols as their ligands.	Oxysterols	190-200	nuclear receptor subfamily 1, group H, member 3	Mus musculus	105-113
10675617-2	2000	Recent findings led to the suggestion that some of these functions are mediated by the nuclear receptors LXRalpha and LXRbeta owing to their potential to bind a group of naturally occurring oxysterols as their ligands.	Oxysterols	190-200	nuclear receptor subfamily 1, group H, member 2	Mus musculus	118-125
11480455-7	2000	LXRa is known to be activated by oxysterols, and the induced expression of the gene may be related to the foam cell formation in atherosclerotic lesions.	Oxysterols	33-43	nuclear receptor subfamily 1 group H member 3	Homo sapiens	0-4
10462436-4	1999	Two other nuclear receptors, designated LXR and FXR, which are respectively activated by oxysterols and bile acids, also play a role in liver P450 expression, in this case regulation of P450 cholesterol 7alpha-hydroxylase, a key enzyme of bile acid biosynthesis.	Oxysterols	89-99	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-146
10462436-4	1999	Two other nuclear receptors, designated LXR and FXR, which are respectively activated by oxysterols and bile acids, also play a role in liver P450 expression, in this case regulation of P450 cholesterol 7alpha-hydroxylase, a key enzyme of bile acid biosynthesis.	Oxysterols	89-99	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	186-190
10439633-4	1999	Oxysterol binds to LXR and thereby induces transcription of cholesterol 7 alpha-hydroxylase, thus increasing the removal of cholesterol as bile acids.	Oxysterols	0-9	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	60-91
9882528-0	1999	Apoptosis induced by oxysterol in CEM cells is associated with negative regulation of c-myc.	Oxysterols	21-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	86-91
10419025-0	1999	Glucocorticoids, oxysterols, and cAMP with glucocorticoids each cause apoptosis of CEM cells and suppress c-myc.	Oxysterols	17-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	106-111
9880570-3	1999	Oxysterols (25-hydroxycholesterol and 7-ketocholesterol) reversed the inhibition of apoB degradation caused by 7alpha-hydroxylase.	Oxysterols	0-10	apolipoprotein B	Homo sapiens	84-88
9882528-2	1999	In the present study, we show that both c-myc mRNA and c-Myc protein levels are reduced only in oxysterol-sensitive and not in oxysterol-resistant cells after treatment with concentrations of 25OHC that kill the sensitive CEM cells.	Oxysterols	96-105	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	40-45
9882528-2	1999	In the present study, we show that both c-myc mRNA and c-Myc protein levels are reduced only in oxysterol-sensitive and not in oxysterol-resistant cells after treatment with concentrations of 25OHC that kill the sensitive CEM cells.	Oxysterols	96-105	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	55-60
9882528-2	1999	In the present study, we show that both c-myc mRNA and c-Myc protein levels are reduced only in oxysterol-sensitive and not in oxysterol-resistant cells after treatment with concentrations of 25OHC that kill the sensitive CEM cells.	Oxysterols	127-136	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	40-45
9804848-3	1998	We examined the effects of oxysterols on the expression of steroidogenic acute regulatory protein (StAR), which increases the delivery of cholesterol to sterol-metabolizing P450s in the mitochondria.	Oxysterols	27-37	steroidogenic acute regulatory protein	Homo sapiens	99-103
9918530-6	1999	Evaluation of the effect of oxysterol components of OxLDL on TIMP-1 production revealed that 25-hydroxycholesterol (1 microg/mL) was the most potent inhibitor ( approximately 30% of control).	Oxysterols	28-37	TIMP metallopeptidase inhibitor 1	Homo sapiens	61-67
9804848-14	1998	We conclude that 1) there are cell-specific effects of oxysterols on SF-1-dependent transactivation; 2) the ability to increase transactivation is limited to certain oxysterols; 3) there are cell-specific pathways of oxysterol metabolism; and 4) oxysterols elevate StAR protein levels through posttranscriptional actions.	Oxysterols	55-64	splicing factor 1	Homo sapiens	69-73
9763219-3	1998	This trait is attributed to increased levels of oxysterols, produced upon partial inhibition of OSC, that suppress HMGR and other sterol-responsive genes.	Oxysterols	48-58	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	115-119
9756919-7	1998	Both ACAT-1 and ACAT-2 also catalyzed the esterification of the 3beta-hydroxyl group of a variety of oxysterols.	Oxysterols	101-111	sterol O-acyltransferase 2	Mus musculus	5-11
9756919-7	1998	Both ACAT-1 and ACAT-2 also catalyzed the esterification of the 3beta-hydroxyl group of a variety of oxysterols.	Oxysterols	101-111	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	16-22
9670991-0	1998	Inhibition of p42/p44 mitogen-activated protein kinase by oxysterols in rat astrocyte primary cultures and C6 glioma cell lines.	Oxysterols	58-68	mitogen activated protein kinase 3	Rattus norvegicus	18-21
9428650-5	1997	These findings underline that these oxysterols could constitute major risk factors in atherosclerosis by their cytotoxicity and their ability to induce IL-1beta release which might favor the recruitment of immunocompetent cells in the atherosclerotic plaque.	Oxysterols	36-46	interleukin 1 beta	Homo sapiens	152-160
9607816-3	1998	A recent publication suggested that transcriptional regulation by SF-1, expressed in a non-steroidogenic CV-1 cells, could be activated by oxysterols suggesting that these compounds could serve as natural ligands for SF-1.	Oxysterols	139-149	splicing factor 1	Mus musculus	66-70
9607816-3	1998	A recent publication suggested that transcriptional regulation by SF-1, expressed in a non-steroidogenic CV-1 cells, could be activated by oxysterols suggesting that these compounds could serve as natural ligands for SF-1.	Oxysterols	139-149	splicing factor 1	Mus musculus	217-221
9422368-8	1998	ApoD was found to be a secreted protein from cultured normal astrocytes and treatment with the oxysterol, 25-hydroxycholesterol, markedly stimulated apoD release (by five- to 10-fold).	Oxysterols	95-104	apolipoprotein D	Mus musculus	0-4
9422368-8	1998	ApoD was found to be a secreted protein from cultured normal astrocytes and treatment with the oxysterol, 25-hydroxycholesterol, markedly stimulated apoD release (by five- to 10-fold).	Oxysterols	95-104	apolipoprotein D	Mus musculus	149-153
8831713-0	1996	Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation.	Oxysterols	0-10	caspase 3	Homo sapiens	69-74
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	Oxysterols	78-88	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	Oxysterols	78-88	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
9247143-0	1997	Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway.	Oxysterols	23-32	B cell leukemia/lymphoma 2	Mus musculus	0-5
9247143-0	1997	Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway.	Oxysterols	23-32	caspase 3	Mus musculus	71-76
9247143-3	1997	Oxysterols (7-ketocholesterol, 25-hydroxycholesterol) induced nuclear condensation and oligonucleosomal DNA fragmentation, which were partially inhibited by Bcl-2 over-expression.	Oxysterols	0-10	B cell leukemia/lymphoma 2	Mus musculus	157-162
9247143-5	1997	These findings indicate that oxysterols induce apoptosis via Bcl-2-inhibitable and -uninhibitable pathways, and the former depends on CPP32 activation.	Oxysterols	29-39	B cell leukemia/lymphoma 2	Mus musculus	61-66
9247143-5	1997	These findings indicate that oxysterols induce apoptosis via Bcl-2-inhibitable and -uninhibitable pathways, and the former depends on CPP32 activation.	Oxysterols	29-39	caspase 3	Mus musculus	134-139
8878485-5	1996	Transactivation of LXR alpha by oxysterols occurs at concentrations at which these compounds exist in vivo.	Oxysterols	32-42	nuclear receptor subfamily 1 group H member 3	Homo sapiens	19-28
9388269-12	1997	Alteration of cellular lipid homeostasis by preincubation in sterol/oxysterol or acetylated low density lipoprotein inhibits apoE, but not total protein, degradation in this fraction.	Oxysterols	68-77	apolipoprotein E	Homo sapiens	125-129
9380679-6	1997	Inhibition of LXRalpha could be reversed by addition of mevalonic acid and certain oxysterols but not by other products of mevalonic acid metabolism.	Oxysterols	83-93	nuclear receptor subfamily 1 group H member 3	Homo sapiens	14-22
9081687-0	1997	Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production.	Oxysterols	74-84	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
9081687-5	1997	When monocytes and monocyte-derived macrophages, in vitro, were exposed to a series of different oxysterols, we found that all oxysterols tested had a tendency to stimulate IL-8 production but that 25-hydroxycholesterol was the most potent one.	Oxysterols	127-137	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
9215799-5	1997	Analysis of lipid composition of Ox-HDL3 by gas chromatography revealed the presence of oxysterols (OS).	Oxysterols	88-98	HDL3	Homo sapiens	36-40
9215799-5	1997	Analysis of lipid composition of Ox-HDL3 by gas chromatography revealed the presence of oxysterols (OS).	Oxysterols	100-102	HDL3	Homo sapiens	36-40
9215799-6	1997	Enrichment of native HDL3 with oxysterols resulted in a reduced capacity to stimulate cholesterol efflux.	Oxysterols	31-41	HDL3	Homo sapiens	21-25
9215799-7	1997	The reduced ability of OS-enriched HDL3 to elicit cholesterol efflux may contribute to cellular cholesterol accumulation and subsequently to atherosclerosis.	Oxysterols	23-25	HDL3	Homo sapiens	35-39
8831713-0	1996	Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation.	Oxysterols	0-10	BCL2 apoptosis regulator	Homo sapiens	99-104
8690807-8	1996	Similar effects on AP-1-binding were seen with the oxysterols, 7beta-hydroxycholesterol, 24- hydroxy-, 25-hydroxy-, and 27-hydroxy-cholesterol.	Oxysterols	51-61	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-23
8690807-9	1996	Our data therefore suggest an effect of oxLDL on the DNA-binding of AP-1, which might be mediated by the oxysterol content of oxLDL.	Oxysterols	105-114	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-72
7578268-5	1995	Oxysterol-resistant cells were isolated by exposing two murine lymphoma cell lines, K36 and EL4, to incremental concentrations of 7-ketocholestanol.	Oxysterols	0-9	epilepsy 4	Mus musculus	92-95
8615754-8	1996	TF antigen expression was the same in oxysterol-treated and control cells as shown by flow cytometry.	Oxysterols	38-47	coagulation factor III, tissue factor	Homo sapiens	0-2
8615754-11	1996	Hence, oxysterol-induced phosphatidylserine exposure and enhanced TF activity may results from apoptosis.	Oxysterols	7-16	coagulation factor III, tissue factor	Homo sapiens	66-68
8567968-9	1996	It is tempting to suggest that an exposure to oxysterols may explain our earlier observation of a low level of LPL mRNA in arterial foam cells.	Oxysterols	46-56	lipoprotein lipase	Homo sapiens	111-114
8820110-10	1996	This effect of BIBX 79 on HMG-CoA reductase is thought to be mainly mediated by oxysterols that are formed by the cyclization of 2,3;22,23-diepoxysqualene.	Oxysterols	80-90	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	26-43
8820113-7	1996	These results suggest that if mitochondrial sterol 27-hydroxylase plays a role in the regulation of LDL receptor activity, it is not through the formation of potent regulatory oxysterols, but through its effects on the availability and/or size of the free cholesterol pool regulating LDL receptor activity.	Oxysterols	176-186	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	44-65
8820113-7	1996	These results suggest that if mitochondrial sterol 27-hydroxylase plays a role in the regulation of LDL receptor activity, it is not through the formation of potent regulatory oxysterols, but through its effects on the availability and/or size of the free cholesterol pool regulating LDL receptor activity.	Oxysterols	176-186	low density lipoprotein receptor	Homo sapiens	100-112
7888303-7	1994	In conclusion, the potentiating effect of oxysterols on AA release seems to be exerted downstream to the growth factor receptor (as demonstrated here with EGF) and probably at the PKC level, but not exclusively.	Oxysterols	42-52	epidermal growth factor like 1	Rattus norvegicus	155-158
7605920-5	1995	Progesterone, a steroid hormone that binds to apoD with high affinity (10(-6) mol l-1) and the oxysterol, 25-hydroxycholesterol which is a potent regulator of cellular cholesterol homeostasis in mammalian cells, differentially stimulated apoD, but not apoE secretion.	Oxysterols	95-104	apolipoprotein D	Homo sapiens	238-242
7605920-5	1995	Progesterone, a steroid hormone that binds to apoD with high affinity (10(-6) mol l-1) and the oxysterol, 25-hydroxycholesterol which is a potent regulator of cellular cholesterol homeostasis in mammalian cells, differentially stimulated apoD, but not apoE secretion.	Oxysterols	95-104	apolipoprotein E	Homo sapiens	252-256
7822296-0	1995	Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system.	Oxysterols	79-88	carboxylesterase 1	Homo sapiens	14-57
7897321-1	1994	The role of oxysterols as regulatory molecules in the suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity was investigated in the intact rat in response to an acute dietary cholesterol challenge.	Oxysterols	12-22	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	69-126
7888303-0	1994	Potentiation by cholesterol and vitamin D3 oxygenated derivatives of arachidonic acid release and prostaglandin E2 synthesis induced by the epidermal growth factor in NRK 49F cells: the role of protein kinase C. We have previously demonstrated that oxysterols and calcitriol potentiate arachidonic acid (AA) release and prostaglandin (PG) synthesis when NRK cells (fibroblastic clone 49F) are activated by foetal calf serum.	Oxysterols	249-259	epidermal growth factor like 1	Rattus norvegicus	140-163
7888303-2	1994	In the present paper, we investigated the effect of some oxysterols and calcitriol on epidermal growth factor (EGF)-induced AA release and PGE2 synthesis in NRK cells.	Oxysterols	57-67	epidermal growth factor like 1	Rattus norvegicus	86-109
7583531-5	1995	Oxysterols but not lysophosphatidylcholine inhibited lipopolysaccharide-induced NF-kappa B activation, suggesting that they may be responsible for the inhibitory effect of Ox-LDL.	Oxysterols	0-10	nuclear factor kappa B subunit 1	Homo sapiens	80-90
7797494-3	1995	In the presence of low density lipoproteins (LDL) normal fibroblasts converted LDL cholesterol to the oxysterol 27-hydroxycholesterol in quantities apparently sufficient to down-regulate 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.	Oxysterols	102-111	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	187-244
7744831-0	1995	Esterification of oxysterols by human plasma lecithin-cholesterol acyltransferase.	Oxysterols	18-28	lecithin-cholesterol acyltransferase	Homo sapiens	45-81
7744831-1	1995	In the present study, lecithin-cholesterol acyltransferase (LCAT) catalyzed esterification of oxysterols was investigated by using discoidal bilayer particles (DBP) containing various oxysterols, phosphatidylcholines, and apolipoprotein A-I.	Oxysterols	94-104	lecithin-cholesterol acyltransferase	Homo sapiens	22-58
7744831-1	1995	In the present study, lecithin-cholesterol acyltransferase (LCAT) catalyzed esterification of oxysterols was investigated by using discoidal bilayer particles (DBP) containing various oxysterols, phosphatidylcholines, and apolipoprotein A-I.	Oxysterols	94-104	lecithin-cholesterol acyltransferase	Homo sapiens	60-64
7744831-1	1995	In the present study, lecithin-cholesterol acyltransferase (LCAT) catalyzed esterification of oxysterols was investigated by using discoidal bilayer particles (DBP) containing various oxysterols, phosphatidylcholines, and apolipoprotein A-I.	Oxysterols	94-104	apolipoprotein A1	Homo sapiens	222-240
7791533-1	1995	Side-chain oxysterols are known to be potent inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, a key regulatory enzyme in the biosynthesis of sterols.	Oxysterols	11-21	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	59-99
7888303-2	1994	In the present paper, we investigated the effect of some oxysterols and calcitriol on epidermal growth factor (EGF)-induced AA release and PGE2 synthesis in NRK cells.	Oxysterols	57-67	epidermal growth factor like 1	Rattus norvegicus	111-114
8057282-4	1994	In the same system, the related oxysterol, 25-hydroxycholesterol (1), at 10 microM lowered both HMGR mRNA levels and LDL-receptor activity by 58% and 64%, respectively.	Oxysterols	32-41	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	96-100
8068724-2	1994	However, the regulatory effects of these oxysterols on cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis, is not clearly elucidated.	Oxysterols	41-51	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	55-86
8057282-4	1994	In the same system, the related oxysterol, 25-hydroxycholesterol (1), at 10 microM lowered both HMGR mRNA levels and LDL-receptor activity by 58% and 64%, respectively.	Oxysterols	32-41	low density lipoprotein receptor	Homo sapiens	117-129
8511800-7	1993	Taken together, our results demonstrate that LOVA is a unique inducer of P450 mRNA in cultured rat hepatocytes and implicate oxysterols as potential intracellular modulators of 2B1/2 induction.	Oxysterols	125-135	UDP glucuronosyltransferase family 2 member B17	Rattus norvegicus	177-182
8217873-0	1993	Oxysterol-induced cell death in human leukemic T-cells correlates with oxysterol binding protein occupancy and is independent of glucocorticoid-induced apoptosis.	Oxysterols	0-9	oxysterol binding protein	Homo sapiens	71-96
8142309-0	1994	Oxysterol sensitive and resistant lymphoid cells: correlation with regulation of cellular nucleic acid binding protein mRNA.	Oxysterols	0-9	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	81-118
8142309-7	1994	The levels of CNBP mRNA are significantly reduced by 25-hydroxycholesterol in the sensitive CEM C7 cells, in which the dose response and time course are consistent with occupancy of the oxysterol binding protein by oxysterol and with subsequent cell kill.	Oxysterols	186-195	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	14-18
8142309-9	1994	Our results suggest a role for CNBP in oxysterol-induced regulation of cell viability and growth.	Oxysterols	39-48	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	31-35
1429619-2	1992	We examined the hypothesis that 7 alpha-hydroxylase may indirectly induce the expression of the LDL receptor by metabolizing, i.e. inactivating oxysterol repressors.	Oxysterols	144-153	low-density lipoprotein receptor	Cricetulus griseus	96-108
1329783-2	1992	Treatment of cells with oxysterol (2.5 microM) resulted in a greater than 90% inhibition of HMG-CoA reductase activity and a 3-fold reduction in its cognate mRNA level.	Oxysterols	24-33	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	92-109
1429619-8	1992	The paradoxical induction of LDL receptor mRNA in transfected cells having greater amounts of cholesterol esters suggests that 7 alpha-hydroxylase may preferentially use oxysterols rather than cholesterol as substrates.	Oxysterols	170-180	low-density lipoprotein receptor	Cricetulus griseus	29-41
1429619-9	1992	The combined data are consistent with the proposal that 7 alpha-hydroxylase indirectly induces the LDL receptor gene by metabolizing (inactivating) oxysterol repressors.	Oxysterols	148-157	low-density lipoprotein receptor	Cricetulus griseus	99-111
2072040-9	1991	The stimulatory effect of HDL on apoE secretion can be clearly dissociated from cholesterol efflux; HDL stimulates apoE secretion from oxysterol-treated cells in the absence of measurable cholesterol efflux, while TNM-HDL promotes substantial cholesterol efflux from cholesterol-loaded cells but has no effect on apoE secretion.	Oxysterols	135-144	apolipoprotein E	Mus musculus	115-119
1895885-0	1991	Oxysterol incorporation into rat aorta resulting in elastin compositional changes.	Oxysterols	0-9	elastin	Rattus norvegicus	52-59
1352965-0	1992	Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for the oxysterol receptor.	Oxysterols	18-27	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	78-118
1782225-11	1991	Thus, along with other biological effects previously reported, oxysterols decrease membrane associated PKC activity in immune cells.	Oxysterols	63-73	proline rich transmembrane protein 2	Homo sapiens	103-106
2072040-9	1991	The stimulatory effect of HDL on apoE secretion can be clearly dissociated from cholesterol efflux; HDL stimulates apoE secretion from oxysterol-treated cells in the absence of measurable cholesterol efflux, while TNM-HDL promotes substantial cholesterol efflux from cholesterol-loaded cells but has no effect on apoE secretion.	Oxysterols	135-144	apolipoprotein E	Mus musculus	115-119
2193823-5	1990	nsL-TP, which is identical to sterol carrier protein 2, transfers all common phospholipids, cholesterol and oxysterol derivatives between membranes.	Oxysterols	108-117	sterol carrier protein 2	Rattus norvegicus	0-6
2193823-5	1990	nsL-TP, which is identical to sterol carrier protein 2, transfers all common phospholipids, cholesterol and oxysterol derivatives between membranes.	Oxysterols	108-117	sterol carrier protein 2	Rattus norvegicus	30-54
30101477-8	2018	We conclude that OSBP and PKD1 form a complex that inhibits both the oxysterol-dependent activity of OSBP at the ER-Golgi and activation of PKD1.	Oxysterols	69-78	oxysterol binding protein	Homo sapiens	17-21
30101477-8	2018	We conclude that OSBP and PKD1 form a complex that inhibits both the oxysterol-dependent activity of OSBP at the ER-Golgi and activation of PKD1.	Oxysterols	69-78	polycystin 1, transient receptor potential channel interacting	Homo sapiens	26-30
30101477-8	2018	We conclude that OSBP and PKD1 form a complex that inhibits both the oxysterol-dependent activity of OSBP at the ER-Golgi and activation of PKD1.	Oxysterols	69-78	oxysterol binding protein	Homo sapiens	101-105
30101477-8	2018	We conclude that OSBP and PKD1 form a complex that inhibits both the oxysterol-dependent activity of OSBP at the ER-Golgi and activation of PKD1.	Oxysterols	69-78	polycystin 1, transient receptor potential channel interacting	Homo sapiens	140-144
34111427-3	2022	Recent work has demonstrated that endogenous cholesterol and oxidized cholesterol derivatives (oxysterols) bind and modulate SMO activity.	Oxysterols	95-105	smoothened, frizzled class receptor	Homo sapiens	125-128
7925343-6	1994	The small amount of 25-hydroxycholesterol 7 alpha-hydroxylase activity retained in a partially purified preparation of cholesterol 7 alpha-hydroxylase was not inhibited by addition of cholesterol, indicating that the oxysterol binding site is different from the cholesterol binding site, presumely due to the presence of two different enzymes.	Oxysterols	217-226	cytochrome P450 family 7 subfamily A member 1	Sus scrofa	30-61
7925343-9	1994	It has been suggested that cholesterol 7 alpha-hydroxylase can preferentially use oxysterols, in particular 25-hydroxycholesterol, as substrates and by this means inactivate important physiological regulators of cholesterol homeostasis.	Oxysterols	82-92	cytochrome P450 family 7 subfamily A member 1	Sus scrofa	27-58
34323663-12	2021	In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-alpha, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01).	Oxysterols	30-39	interleukin 33	Homo sapiens	82-87
34808332-5	2022	The present study evaluated the anti-inflammatory mechanisms of oxysterols, blood brain barrier (BBB) penetrable bioactive lipids, revealing that this intervention suppresses neuroinflammation by disrupting membrane lipid raft formation and caveolae-mediated endosomal IFN-gamma signaling.	Oxysterols	64-74	interferon gamma	Homo sapiens	269-278
34783962-5	2022	Endoglin expression is up-regulated in preeclamptic placentas, through mechanisms mainly induced by hypoxia, oxidative stress and oxysterol-mediated activation of liver X receptors.	Oxysterols	130-139	endoglin	Homo sapiens	0-8
34601222-9	2021	This methoxybenzoic acid down-regulated the oxysterol-induced expression of EDEM1, OS9, Sel1L-Hrd1 and p97/VCP1, all required for the recognition, recruitment and dislocation of misfolded proteins.	Oxysterols	44-53	ER degradation enhancer, mannosidase alpha-like 1	Mus musculus	76-81
34601222-9	2021	This methoxybenzoic acid down-regulated the oxysterol-induced expression of EDEM1, OS9, Sel1L-Hrd1 and p97/VCP1, all required for the recognition, recruitment and dislocation of misfolded proteins.	Oxysterols	44-53	amplified in osteosarcoma	Mus musculus	83-86
34601222-9	2021	This methoxybenzoic acid down-regulated the oxysterol-induced expression of EDEM1, OS9, Sel1L-Hrd1 and p97/VCP1, all required for the recognition, recruitment and dislocation of misfolded proteins.	Oxysterols	44-53	sel-1 suppressor of lin-12-like (C. elegans)	Mus musculus	88-93
34601222-9	2021	This methoxybenzoic acid down-regulated the oxysterol-induced expression of EDEM1, OS9, Sel1L-Hrd1 and p97/VCP1, all required for the recognition, recruitment and dislocation of misfolded proteins.	Oxysterols	44-53	synovial apoptosis inhibitor 1, synoviolin	Mus musculus	94-98
34601222-9	2021	This methoxybenzoic acid down-regulated the oxysterol-induced expression of EDEM1, OS9, Sel1L-Hrd1 and p97/VCP1, all required for the recognition, recruitment and dislocation of misfolded proteins.	Oxysterols	44-53	valosin containing protein	Mus musculus	103-106
34323663-12	2021	In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-alpha, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01).	Oxysterols	30-39	vascular endothelial growth factor A	Homo sapiens	126-130
34323663-12	2021	In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-alpha, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01).	Oxysterols	30-39	coagulation factor III, tissue factor	Homo sapiens	135-148
34323663-12	2021	In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-alpha, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01).	Oxysterols	30-39	tumor necrosis factor	Homo sapiens	89-98
34323663-12	2021	In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-alpha, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01).	Oxysterols	30-39	C-C motif chemokine ligand 2	Homo sapiens	111-116
34323663-12	2021	In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-alpha, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01).	Oxysterols	30-39	intercellular adhesion molecule 1	Homo sapiens	118-124
34492054-11	2021	In each drug-stimulated group, both ICAM-1 mRNA and protein levels were reduced after initial incubation with oxysterol (p<0.05).	Oxysterols	110-119	intercellular adhesion molecule 1	Homo sapiens	36-42
34505423-4	2021	Oxy210, an oxysterol derivative, displays the unique property of antagonizing both Hedgehog (Hh) and transforming growth factor-beta (TGF-beta) signalling in primary human hepatic stellate cells (HSC).	Oxysterols	11-20	tumor necrosis factor	Homo sapiens	101-132
34505423-4	2021	Oxy210, an oxysterol derivative, displays the unique property of antagonizing both Hedgehog (Hh) and transforming growth factor-beta (TGF-beta) signalling in primary human hepatic stellate cells (HSC).	Oxysterols	11-20	transforming growth factor alpha	Homo sapiens	134-142
34239694-1	2021	The oxysterol 27-hydroxycholesterol (27HC) is the first identified endogenous selective estrogen receptor modulator (SERM), which like endogenous estrogen 17beta-estradiol (E2) induces the proliferation of estrogen receptor- (ER-) positive breast cancer cells in vitro.	Oxysterols	4-13	estrogen receptor 1	Danio rerio	206-223
34270165-1	2021	The G protein-coupled receptor GPR183/EBI2, which is activated by oxysterols, is a therapeutic target for inflammatory and metabolic diseases where both antagonists and agonists are of potential interest.	Oxysterols	66-76	G protein-coupled receptor 183	Homo sapiens	31-37
34270165-1	2021	The G protein-coupled receptor GPR183/EBI2, which is activated by oxysterols, is a therapeutic target for inflammatory and metabolic diseases where both antagonists and agonists are of potential interest.	Oxysterols	66-76	G protein-coupled receptor 183	Homo sapiens	38-42
34298014-4	2021	Herein, we show that INSIGs mediate ATF4 upregulation upon interaction with oxysterol.	Oxysterols	76-85	activating transcription factor 4	Homo sapiens	36-40
34298014-5	2021	Oxysterols that possess a high affinity for INSIG, such as 27- and 25-hydroxycholesterol (25HC), markedly induced the increase of ATF4 protein when compared with other oxysterols.	Oxysterols	0-10	activating transcription factor 4	Homo sapiens	130-134
34298014-5	2021	Oxysterols that possess a high affinity for INSIG, such as 27- and 25-hydroxycholesterol (25HC), markedly induced the increase of ATF4 protein when compared with other oxysterols.	Oxysterols	168-178	activating transcription factor 4	Homo sapiens	130-134
34281217-6	2021	In the liver, oxysterol-mediated LXR activation stimulated the synthesis of bile acids and in particular increased the levels of hydrophilic muricholic acids, which in turn reduced FXR signaling, as assessed in vivo with Fxr reporter mice.	Oxysterols	14-23	nuclear receptor subfamily 1, group H, member 3	Mus musculus	33-36
34281217-6	2021	In the liver, oxysterol-mediated LXR activation stimulated the synthesis of bile acids and in particular increased the levels of hydrophilic muricholic acids, which in turn reduced FXR signaling, as assessed in vivo with Fxr reporter mice.	Oxysterols	14-23	nuclear receptor subfamily 1, group H, member 4	Mus musculus	181-184
34281217-6	2021	In the liver, oxysterol-mediated LXR activation stimulated the synthesis of bile acids and in particular increased the levels of hydrophilic muricholic acids, which in turn reduced FXR signaling, as assessed in vivo with Fxr reporter mice.	Oxysterols	14-23	nuclear receptor subfamily 1, group H, member 4	Mus musculus	221-224
34440907-3	2021	Recently, SMO is also shown to be regulated by small molecules, such as oxysterol, cholesterol, and phospholipid.	Oxysterols	72-81	smoothened, frizzled class receptor	Homo sapiens	10-13
34158867-10	2021	LDHB downregulation skewed TAMs to function as a lactate and sterol/oxysterol source for the proliferation of tumor cells.	Oxysterols	68-77	lactate dehydrogenase B	Homo sapiens	0-4
35462094-2	2022	Oxysterols (endogenous oxidized cholesterol derivatives) are the most potent endogenous LXRalpha-agonist.	Oxysterols	0-10	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	88-96
35462094-4	2022	OBJECTIVE: The current study aimed to investigate the effect of LXRalpha-activation by either endogenous oxysterols or a synthetic LXRalpha-agonist (LXRa) such as TO901317 on hepatic and cardiac gene expression of ABCC10 and SLC17A5 drug transporters in an experimentally hypercholesterolemic rat model.	Oxysterols	105-115	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	64-72
35462094-4	2022	OBJECTIVE: The current study aimed to investigate the effect of LXRalpha-activation by either endogenous oxysterols or a synthetic LXRalpha-agonist (LXRa) such as TO901317 on hepatic and cardiac gene expression of ABCC10 and SLC17A5 drug transporters in an experimentally hypercholesterolemic rat model.	Oxysterols	105-115	ATP binding cassette subfamily C member 10	Rattus norvegicus	214-220
35462094-4	2022	OBJECTIVE: The current study aimed to investigate the effect of LXRalpha-activation by either endogenous oxysterols or a synthetic LXRalpha-agonist (LXRa) such as TO901317 on hepatic and cardiac gene expression of ABCC10 and SLC17A5 drug transporters in an experimentally hypercholesterolemic rat model.	Oxysterols	105-115	solute carrier family 17 member 5	Rattus norvegicus	225-232
35234362-1	2022	ATP-binding cassette transporter G1 (ABCG1) is a cellular transmembrane protein that transports oxysterol efflux from cells to high-density lipoprotein (HDL) particles in the plasma.	Oxysterols	96-105	ATP binding cassette subfamily G member 1	Mus musculus	0-35
35560019-9	2022	The transcription of IDOL was restored by adding either an LXR agonist T0901317 or oxysterol 22(R)-hydroxycholesterol, indicating that statin inhibited IDOL expression by reducing LXR activation.	Oxysterols	83-92	myosin regulatory light chain interacting protein	Homo sapiens	21-25
35560019-9	2022	The transcription of IDOL was restored by adding either an LXR agonist T0901317 or oxysterol 22(R)-hydroxycholesterol, indicating that statin inhibited IDOL expression by reducing LXR activation.	Oxysterols	83-92	myosin regulatory light chain interacting protein	Homo sapiens	152-156
35575904-0	2022	Oxysterol Compounds in Mouse Mutant alphaA- and alphaB-Crystallin Lenses Can Improve the Optical Properties of the Lens.	Oxysterols	0-9	crystallin, alpha B	Mus musculus	48-65
35303091-3	2022	We found upregulation of the oxysterol-producing enzymes CH25H and CYP7B1 and increased concentrations of 25-hydroxycholesterol upon Mtb infection in the lungs of mice.	Oxysterols	29-38	cholesterol 25-hydroxylase	Mus musculus	57-62
35303091-3	2022	We found upregulation of the oxysterol-producing enzymes CH25H and CYP7B1 and increased concentrations of 25-hydroxycholesterol upon Mtb infection in the lungs of mice.	Oxysterols	29-38	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	67-73
35577580-9	2022	In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01).	Oxysterols	27-36	transforming growth factor alpha	Homo sapiens	94-102
35577580-9	2022	In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01).	Oxysterols	27-36	interleukin 37	Homo sapiens	104-109
35577580-9	2022	In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01).	Oxysterols	27-36	Epstein-Barr virus induced 3	Homo sapiens	143-147
35577580-9	2022	In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01).	Oxysterols	27-36	interleukin 12A	Homo sapiens	149-152
35577580-9	2022	In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01).	Oxysterols	27-36	interleukin 23 subunit alpha	Homo sapiens	154-159
35577580-9	2022	In HUVECs pre-treated with oxysterol, rivaroxaban and dabigatran increased mRNA expression of TGF-beta, IL-37 and decreased mRNA expression of EBI3, p35, IL-23 and IL-18 as compared to 25-OHC(p<0.01).	Oxysterols	27-36	interleukin 18	Homo sapiens	164-169
34981658-6	2022	Accumulations of secondary bile acids and oxysterols were found in both the serum and liver tissue of LXRalpha activated mice.	Oxysterols	42-52	nuclear receptor subfamily 1, group H, member 3	Mus musculus	102-110
34981658-9	2022	Conclusion: Our results indicated that chronic activation of LXRalpha promotes HCC, at least in part, by promoting innate immune suppressor as a result of accumulation of oxysterols, as well as up-regulation of the IL-6/Janus kinase/STAT3 signaling and complement pathways.	Oxysterols	171-181	nuclear receptor subfamily 1, group H, member 3	Mus musculus	61-69
35234362-1	2022	ATP-binding cassette transporter G1 (ABCG1) is a cellular transmembrane protein that transports oxysterol efflux from cells to high-density lipoprotein (HDL) particles in the plasma.	Oxysterols	96-105	ATP binding cassette subfamily G member 1	Mus musculus	37-42
35234362-2	2022	Previous studies have demonstrated that an ABCG1 deficiency exerts an antiatherosclerotic function through the effects of oxysterol accumulation in cells to enhance apoptosis and regulate inflammatory processes.	Oxysterols	122-131	ATP binding cassette subfamily G member 1	Mus musculus	43-48
35234362-3	2022	However, whether the deficiency of ABCG1 and the corresponding changes in the efflux of oxysterols could take a series of impacts on the proteomic composition of HDL remains unclear.	Oxysterols	88-98	ATP binding cassette subfamily G member 1	Mus musculus	35-40
35537452-0	2022	Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.	Oxysterols	14-23	G protein-coupled receptor 183	Homo sapiens	31-35
35537452-0	2022	Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.	Oxysterols	14-23	G protein-coupled receptor 183	Homo sapiens	36-42
35537452-1	2022	Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive immunity and antibody production during infection.	Oxysterols	0-10	G protein-coupled receptor 183	Homo sapiens	136-140
35537452-1	2022	Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive immunity and antibody production during infection.	Oxysterols	0-10	G protein-coupled receptor 183	Homo sapiens	142-148
35537452-5	2022	Mutations within the oxysterol binding site and the Galphai interface attenuate G protein signaling and abolish oxysterol-mediated cell migration indicating that G protein signaling directly involves in the oxysterol-EBI2 pathway.	Oxysterols	112-121	G protein-coupled receptor 183	Homo sapiens	217-221
35464321-5	2022	27-hydroxycholesterol (27-OHC) is the major peripheral oxysterol that flows into the brain, and it affects beta-amyloid (Abeta) production and elimination as well as influencing other pathogenic mechanisms of AD.	Oxysterols	55-64	amyloid beta precursor protein	Homo sapiens	121-126
35121342-11	2022	In HUVECs pre-stimulated with oxysterol, dabigatran stimulation decreased mRNA expression of the proinflammatory cytokines IL-33 and TNF-alpha, chemokines MCP-1 ICAM-1 and VEGF (p < 0.01).	Oxysterols	30-39	interleukin 33	Homo sapiens	123-128
35386720-4	2022	Macrophage exposure to oxidized LDLs (oxLDLs) or to necrotic plaque debris enriched with oxysterols induces HIF-1alpha -dependent pathways.	Oxysterols	89-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
35386720-11	2022	In conclusion, the impact of HIF-1alpha on cholesterol homeostasis within macrophages and the feedback activation of the inflammatory response by oxysterols via HIF-1alpha could play a deleterious role in atherosclerosis.	Oxysterols	146-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-39
35386720-11	2022	In conclusion, the impact of HIF-1alpha on cholesterol homeostasis within macrophages and the feedback activation of the inflammatory response by oxysterols via HIF-1alpha could play a deleterious role in atherosclerosis.	Oxysterols	146-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
35121342-11	2022	In HUVECs pre-stimulated with oxysterol, dabigatran stimulation decreased mRNA expression of the proinflammatory cytokines IL-33 and TNF-alpha, chemokines MCP-1 ICAM-1 and VEGF (p < 0.01).	Oxysterols	30-39	tumor necrosis factor	Homo sapiens	133-142
35082691-11	2021	In huCETP females, CETP in the circulation decreased HDL-cholesterol content and increased liver cholesterol uptake and liver cholesterol and oxysterol contents, which was associated with the upregulation of LXR target genes in long-chain polyunsaturated fatty acid biosynthesis and PPARalpha target genes in fatty acid beta-oxidation in the liver.	Oxysterols	142-151	cholesteryl ester transfer protein	Homo sapiens	19-23
35082691-11	2021	In huCETP females, CETP in the circulation decreased HDL-cholesterol content and increased liver cholesterol uptake and liver cholesterol and oxysterol contents, which was associated with the upregulation of LXR target genes in long-chain polyunsaturated fatty acid biosynthesis and PPARalpha target genes in fatty acid beta-oxidation in the liver.	Oxysterols	142-151	nuclear receptor subfamily 1, group H, member 3	Mus musculus	208-211
32855528-5	2021	Mechanistically, ABT-199 acts as a competitive inhibitor of oxysterol by potentially targeting the cysteine rich domain (CRD) of Smo, rather as a BH3 mimetic.	Oxysterols	60-69	smoothened, frizzled class receptor	Homo sapiens	129-132
2742872-0	1989	Transfer of cholesterol and oxysterol derivatives by the nonspecific lipid transfer protein (sterol carrier protein 2): a study on its mode of action.	Oxysterols	28-37	sterol carrier protein 2	Homo sapiens	57-91
2742872-0	1989	Transfer of cholesterol and oxysterol derivatives by the nonspecific lipid transfer protein (sterol carrier protein 2): a study on its mode of action.	Oxysterols	28-37	sterol carrier protein 2	Homo sapiens	93-117
2742872-4	1989	In the presence of nsLTP, the transport of both cholesterol and the oxysterol derivatives was greatly enhanced; the highest rate of transport was observed for 25-hydroxycholesterol.	Oxysterols	68-77	sterol carrier protein 2	Homo sapiens	19-24
3382396-1	1988	6-Nitrocholesterol has been shown to cause a 50% reduction in the level of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in animal cells in culture at 1.9 microM and it has relative binding affinity for the cytosolic oxysterol binding protein of 357 nM in cell-free extracts from the same cell line.	Oxysterols	228-237	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	75-122
3782148-7	1986	The major oxysterol intermediate accumulated under all the conditions described above is the C-32 aldehyde in an approximate 3:1 ratio to the C-32 alcohol.	Oxysterols	10-19	chemokine like factor	Homo sapiens	93-97
3821388-1	1986	The intestinal absorption of 5,6 alpha-epoxy-5 alpha-cholesta-3 beta-ol, an oxysterol formed by cholesterol autoxidation, has been evaluated in the male Wistar rat.	Oxysterols	76-85	integrin subunit beta 1	Rattus norvegicus	64-71
3390173-3	1988	Incubation with 10 micrograms/ml of oxysterol also reduced the total apo-B secretion measured by ELISA and increased intracellular apo-B mRNA level.	Oxysterols	36-45	apolipoprotein B	Homo sapiens	69-74
3390173-3	1988	Incubation with 10 micrograms/ml of oxysterol also reduced the total apo-B secretion measured by ELISA and increased intracellular apo-B mRNA level.	Oxysterols	36-45	apolipoprotein B	Homo sapiens	131-136
6490619-1	1984	Support for the role of a cytosolic oxysterol-binding protein in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was obtained by correlating the relative binding affinities of a wide range of oxysterols to their potency in suppressing HMG-CoA reductase activity in mouse fibroblast cell cultures.	Oxysterols	220-230	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	83-140
6736025-0	1984	Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by oxysterol by-products of cholesterol biosynthesis.	Oxysterols	65-74	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	14-61
33631213-3	2021	Here, we show that 4beta-hydroxycholesterol (4beta-HC), a liver and serum abundant oxysterol of poorly defined function, is a potent and selective inducer of the master lipogenic transcription factor, Sterol Regulatory Element Binding Protein 1c (SREBP1c), but not the related steroidogenic transcription factor SREBP2.	Oxysterols	83-92	sterol regulatory element binding transcription factor 1	Mus musculus	201-245
33118626-5	2021	The second part concentrates in the effects of 24S-HC at the cellular level, describing how this oxysterol affects cell viability, amyloid beta production, neurotransmission, and transcriptional activity.	Oxysterols	97-106	amyloid beta precursor protein	Homo sapiens	131-143
33792095-5	2021	RESULTS: As expected PCSK9ab treatment lowered serum cholesterol and oxysterol levels after 1 month.	Oxysterols	69-78	proprotein convertase subtilisin/kexin type 9	Homo sapiens	21-26
33631213-5	2021	Unique among the oxysterol agonists of LXR, 4beta-HC induced expression of the lipogenic program downstream of SREBP1c and triggered de novo lipogenesis both in primary hepatocytes and in mouse liver.	Oxysterols	17-26	nuclear receptor subfamily 1, group H, member 3	Mus musculus	39-42
33361391-1	2021	Liver X receptors (LXR) are transcription factors from the nuclear receptor family that are activated by oxysterols and synthetic high-affinity agonists.	Oxysterols	105-115	nuclear receptor subfamily 1, group H, member 3	Mus musculus	0-17
33717065-4	2021	Therefore, in the present study putative genes encoding for CH25H were identified and amplified in common carp and rainbow trout cells and an HPLC-MS method was applied for determination of oxysterol concentrations in these cells under virus infection.	Oxysterols	190-199	cholesterol 25-hydroxylase	Homo sapiens	60-65
33361391-1	2021	Liver X receptors (LXR) are transcription factors from the nuclear receptor family that are activated by oxysterols and synthetic high-affinity agonists.	Oxysterols	105-115	nuclear receptor subfamily 1, group H, member 3	Mus musculus	19-22
33359561-5	2021	In U937 promonocytic cells and in human umbilical vein endothelial cells, an oxysterol mixture and HNE were able to up-regulate the level and activity of PCSK6, resulting in MMP-9 activation as demonstrated by PCSK6 silencing.	Oxysterols	77-86	proprotein convertase subtilisin/kexin type 6	Homo sapiens	154-159
33359561-5	2021	In U937 promonocytic cells and in human umbilical vein endothelial cells, an oxysterol mixture and HNE were able to up-regulate the level and activity of PCSK6, resulting in MMP-9 activation as demonstrated by PCSK6 silencing.	Oxysterols	77-86	matrix metallopeptidase 9	Homo sapiens	174-179
33359561-5	2021	In U937 promonocytic cells and in human umbilical vein endothelial cells, an oxysterol mixture and HNE were able to up-regulate the level and activity of PCSK6, resulting in MMP-9 activation as demonstrated by PCSK6 silencing.	Oxysterols	77-86	proprotein convertase subtilisin/kexin type 6	Homo sapiens	210-215
33359561-7	2021	For the first time, we demonstrated that both oxysterols and HNE, which substantially accumulate in the atherosclerotic plaque, up-regulate the activity of PCSK6.	Oxysterols	46-56	proprotein convertase subtilisin/kexin type 6	Homo sapiens	156-161
33525692-6	2021	ROS and STAT3 activation has been correlated with the production of oxysterols and other hydroxylated fatty acids, and they have been recognized important as players of atherogenesis and cardiocirculatory system diseases.	Oxysterols	68-78	signal transducer and activator of transcription 3	Homo sapiens	8-13
33360775-9	2021	Moreover, astrocyte conditioned media analysis revealed a significant increase in the release of Lcn2, cytokines, and chemokines in response to oxysterols.	Oxysterols	144-154	lipocalin 2	Mus musculus	97-101
33360775-10	2021	A significant reduction of postsynaptic density protein 95 (PSD95) and a concurrent increase in cleaved caspase-3 protein levels have been demonstrated in neurons co-cultured with oxysterol-treated astrocytes, pointing out that mediators released by astrocytes have an impact on neurons.	Oxysterols	180-189	discs large MAGUK scaffold protein 4	Mus musculus	27-58
33360775-10	2021	A significant reduction of postsynaptic density protein 95 (PSD95) and a concurrent increase in cleaved caspase-3 protein levels have been demonstrated in neurons co-cultured with oxysterol-treated astrocytes, pointing out that mediators released by astrocytes have an impact on neurons.	Oxysterols	180-189	discs large MAGUK scaffold protein 4	Mus musculus	60-65
33360775-10	2021	A significant reduction of postsynaptic density protein 95 (PSD95) and a concurrent increase in cleaved caspase-3 protein levels have been demonstrated in neurons co-cultured with oxysterol-treated astrocytes, pointing out that mediators released by astrocytes have an impact on neurons.	Oxysterols	180-189	caspase 3	Mus musculus	104-113
33360775-13	2021	Lcn2 has been shown to exert a key role in mediating the synaptotoxic effect of oxysterol-treated astrocytes.	Oxysterols	80-89	lipocalin 2	Mus musculus	0-4
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	Oxysterols	88-97	NLR family, pyrin domain containing 3	Mus musculus	132-137
33141061-5	2021	ABCG4 is thought to transport cholesterol, oxysterols and cholesterol synthesis intermediates, and was recently found on the blood brain barrier (BBB), implicated in amyloid-beta export.	Oxysterols	43-53	ATP binding cassette subfamily G member 4	Homo sapiens	0-5
33141061-6	2021	In this study, we investigate the regulation of ABCG4 by oxysterols, cholesterol-synthesis intermediates and cholesterol itself.	Oxysterols	57-67	ATP binding cassette subfamily G member 4	Homo sapiens	48-53
33141061-7	2021	METHODS: ABC transporter expression was measured in neuroblastoma and gliablastoma cell lines and cells overexpressing ABCG4 in response to synthetic LXR ligands, oxysterols and cholesterol-synthesis intermediates.	Oxysterols	163-173	ATP binding cassette subfamily G member 4	Homo sapiens	119-124
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	Oxysterols	88-97	interleukin 1 alpha	Mus musculus	296-304
33242792-13	2020	Oxysterols are endogenous LXR ligands, implying that simvastatin suppresses ANGPTL3 secretion via reduced oxysterol-mediated LXR activation.	Oxysterols	0-10	angiopoietin like 3	Homo sapiens	76-83
33315900-3	2020	We previously identified a series of oxysterol derivatives and phenanthridine-6-one derivatives as pharmacological chaperones, i.e., small molecules that can rescue folding-defective phenotypes of mutated NPC1, opening up an avenue to develop chaperone therapy for Niemann-Pick disease type C. Here, we present an improved image-based screen for NPC1 chaperones and we describe its application for drug-repurposing screening.	Oxysterols	37-46	NPC intracellular cholesterol transporter 1	Homo sapiens	205-209
33315900-3	2020	We previously identified a series of oxysterol derivatives and phenanthridine-6-one derivatives as pharmacological chaperones, i.e., small molecules that can rescue folding-defective phenotypes of mutated NPC1, opening up an avenue to develop chaperone therapy for Niemann-Pick disease type C. Here, we present an improved image-based screen for NPC1 chaperones and we describe its application for drug-repurposing screening.	Oxysterols	37-46	NPC intracellular cholesterol transporter 1	Homo sapiens	346-350
33242792-13	2020	Oxysterols are endogenous LXR ligands, implying that simvastatin suppresses ANGPTL3 secretion via reduced oxysterol-mediated LXR activation.	Oxysterols	106-115	angiopoietin like 3	Homo sapiens	76-83
33242792-14	2020	CONCLUSIONS: Statins lower plasma ANGPTL3 concentrations in hypercholesterolemic patients, likely due to decreased oxysterol-mediated LXR activation.	Oxysterols	115-124	angiopoietin like 3	Homo sapiens	34-41
33008924-0	2020	Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition.	Oxysterols	50-59	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	32-38
32896622-9	2020	The mechanism of steatosis was increased expression of Srebp1 (positive regulator of liver lipogenesis) through activation of the liver X receptor by increased oxysterols in the CA-fed rats, especially 4beta-hydroxycholesterol (4betaOH) formed by upregulated expression of hepatic Cyp3a2, responsible for 4betaOH formation.	Oxysterols	160-170	sterol regulatory element binding transcription factor 1	Rattus norvegicus	55-61
33134439-1	2020	The raw datasets of oxysterol quantifications from whole cell and mitochondrial fractions of THP-1 monocytes and macrophages, neuronal-like SH-SH5Y cells and human peripheral blood mononuclear cells are presented.	Oxysterols	20-29	GLI family zinc finger 2	Homo sapiens	93-98
32913007-3	2020	GPR183 is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7alpha,25-dihydroxycholesterol (7alpha,25-OHC).	Oxysterols	115-124	G protein-coupled receptor 183	Rattus norvegicus	0-6
33192294-7	2020	Our results suggest that rodents show similarity to humans for studying the impact of CYP46A1 inhibitors and that rapid, local modulation of oxysterols can be achieved through CYP46A1 inhibition.	Oxysterols	141-151	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	176-183
33134439-5	2020	These datasets provide new information about the oxysterol distribution in THP-1 monocytes and macrophages, SH-SY5Y cells and peripheral blood mononuclear cells.	Oxysterols	49-58	GLI family zinc finger 2	Homo sapiens	75-80
32777483-4	2020	First, esterification of side-chain oxysterols by LPLA2 was investigated using recombinant mouse LPLA2 and dioleoyl-PC/sulfatide/oxysterol liposomes under acidic conditions.	Oxysterols	36-46	phospholipase A2, group XV	Mus musculus	50-55
32777483-15	2020	This suggests that there is an esterification pathway of side-chain oxysterols via LPLA2.	Oxysterols	68-78	phospholipase A2, group XV	Mus musculus	83-88
32777483-4	2020	First, esterification of side-chain oxysterols by LPLA2 was investigated using recombinant mouse LPLA2 and dioleoyl-PC/sulfatide/oxysterol liposomes under acidic conditions.	Oxysterols	36-46	phospholipase A2, group XV	Mus musculus	97-102
32777483-4	2020	First, esterification of side-chain oxysterols by LPLA2 was investigated using recombinant mouse LPLA2 and dioleoyl-PC/sulfatide/oxysterol liposomes under acidic conditions.	Oxysterols	36-45	phospholipase A2, group XV	Mus musculus	50-55
32777483-4	2020	First, esterification of side-chain oxysterols by LPLA2 was investigated using recombinant mouse LPLA2 and dioleoyl-PC/sulfatide/oxysterol liposomes under acidic conditions.	Oxysterols	36-45	phospholipase A2, group XV	Mus musculus	97-102
32777483-9	2020	N-acetylsphingosine (NAS) acting as an acyl acceptor in LPLA2 transacylation inhibited the side-chain oxysterol esterification by LPLA2.	Oxysterols	102-111	phospholipase A2, group XV	Mus musculus	56-61
32777483-9	2020	N-acetylsphingosine (NAS) acting as an acyl acceptor in LPLA2 transacylation inhibited the side-chain oxysterol esterification by LPLA2.	Oxysterols	102-111	phospholipase A2, group XV	Mus musculus	130-135
32777483-13	2020	The docking model of acyl-LPLA2 intermediate and side-chain oxysterol provided new insight to elucidate the transacylation mechanism of sterols by LPLA2.	Oxysterols	60-69	phospholipase A2, group XV	Mus musculus	147-152
32229247-4	2020	Cholesterol 25-Hydroxylase (CH25H) converts cholesterol into 25-Hydroxycholesterol (25-HC), an oxysterol that modulates immune responses.	Oxysterols	95-104	cholesterol 25-hydroxylase	Homo sapiens	0-26
32809272-2	2020	Sterol regulatory element-binding protein (SREBP) is a key transcriptional factor for lipogenesis and activated by reduced sterol and oxysterol levels.	Oxysterols	134-143	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	0-41
32809272-2	2020	Sterol regulatory element-binding protein (SREBP) is a key transcriptional factor for lipogenesis and activated by reduced sterol and oxysterol levels.	Oxysterols	134-143	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	43-48
32561542-8	2020	We conclude that LCAT has a major role in the FA esterification of many plasma oxysterols, but contributes little to the FA esterification of 4betaHC.	Oxysterols	79-89	lecithin-cholesterol acyltransferase	Homo sapiens	17-21
32229247-4	2020	Cholesterol 25-Hydroxylase (CH25H) converts cholesterol into 25-Hydroxycholesterol (25-HC), an oxysterol that modulates immune responses.	Oxysterols	95-104	cholesterol 25-hydroxylase	Homo sapiens	28-33