PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28801182-2	2017	In our previous paper (Drug Metabolism Parmacokinet31: 363, 2016), a simulation system for ligand interactions of human CYP1A2 was developed using "Template" composed of hexagonal grids focusing on polyaromatic hydrocarbons (PAHs).	pahs	225-229	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	120-126
30950278-3	2019	CYP1A1, one of the three isoforms of the CYP1 family, is widely believed to play an important role in the metabolism and activation of numerous procarcinogens, e.g., polyaromatic hydrocarbons (PAHs) or aromatic amines.	pahs	193-197	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
29568443-1	2017	Heteroatom doping into polyaromatic hydrocarbons (PAHs) is a powerful approach for modifying key physical properties, however, there are extremely few modular routes that enable facile formation of B-, B2- and B,N-(specifically not containing direct B-N bonds) doped PAHs despite the growing importance of these materials.	pahs	50-54	immunoglobulin kappa variable 5-2	Homo sapiens	202-211
33476717-8	2021	Altogether, the present findings substantiate that AhR-mediated responses of CPs technical mixtures in the DR-CALUX bioassay are caused by impurities, most likely some intermediate stable AhR-agonists such as dioxin-like PCNs or (chlorinated) PAHs.	pahs	243-247	aryl hydrocarbon receptor	Homo sapiens	51-54
31203030-5	2019	The PAH concentrations in biochars ranged greatly, with the dominant proportion being 2-3 ringed PAHs (40%-71%).	pahs	97-101	phenylalanine hydroxylase	Homo sapiens	4-7
27581621-8	2016	Bone defects treated with MSCs in BMP-2 PAHs demonstrate 100% union as early as 8 weeks and significantly higher bone volumes at 12 weeks, while defects with MSC-entrapped PAHs alone do not fully bridge.	pahs	40-44	bone morphogenetic protein 2	Homo sapiens	34-39
26552516-2	2016	To date, few studies have investigated in vivo CYP1A2 induction in humans and its relationship to polycylic aromatic hydrocarbons (PAHs) like benzo(a)pyrene (BaP).	pahs	131-135	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-53
27060237-1	2016	Several studies have reported on the interaction between vitamin A (VA) and aryl hydrocarbon receptor (AhR)-binding toxicants, including poly-aromatic hydrocarbons (PAHs).	pahs	165-169	aryl hydrocarbon receptor	Salmo salar	103-106
26618301-9	2016	The antioxidant response genes (Nqo1 and Hmox1) were moderately associated with polyaromatic hydrocarbons (PAHs) and showed a good correlation (r-Pearson of >0.7) with metals linked to vehicle-related emissions (i.e. Cu, Zn and Sb).	pahs	107-111	NAD(P)H quinone dehydrogenase 1	Homo sapiens	32-36
26618301-9	2016	The antioxidant response genes (Nqo1 and Hmox1) were moderately associated with polyaromatic hydrocarbons (PAHs) and showed a good correlation (r-Pearson of >0.7) with metals linked to vehicle-related emissions (i.e. Cu, Zn and Sb).	pahs	107-111	heme oxygenase 1	Homo sapiens	41-46
17687729-8	2007	Elevated COX-2 levels may be associated with enhanced metabolism of PAHs through cooxidation-peroxidase pathways.	pahs	68-72	prostaglandin G/H synthase 2	Fundulus heteroclitus	9-14
22423853-6	2012	This leads to reduced electron spin-spin interaction and hence almost negligible intrinsic magnetism in the carbon-based PAHs and carbon nanographene fragments.	pahs	121-125	spindlin 1	Homo sapiens	31-35
22423853-6	2012	This leads to reduced electron spin-spin interaction and hence almost negligible intrinsic magnetism in the carbon-based PAHs and carbon nanographene fragments.	pahs	121-125	spindlin 1	Homo sapiens	36-40
22718620-1	2012	The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways.	pahs	113-117	aryl hydrocarbon receptor	Homo sapiens	4-29
22718620-1	2012	The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways.	pahs	113-117	aryl hydrocarbon receptor	Homo sapiens	31-34
22296395-2	2011	The aryl hydrocarbon receptor (AhR) mediates endocrine disruptive activities of polyaromatic hydrocarbons (PAHs) and dioxins, which may compromise ovarian functions of women in polluted environments.	pahs	107-111	aryl hydrocarbon receptor	Homo sapiens	4-29
22296395-2	2011	The aryl hydrocarbon receptor (AhR) mediates endocrine disruptive activities of polyaromatic hydrocarbons (PAHs) and dioxins, which may compromise ovarian functions of women in polluted environments.	pahs	107-111	aryl hydrocarbon receptor	Homo sapiens	31-34
21644163-7	2011	The risk assessment was conducted using the toxic equivalent factor (TEF) considering the toxicity of the individual PAHs compared to BaP.	pahs	117-121	TEF transcription factor, PAR bZIP family member	Homo sapiens	69-72
17711870-1	2007	BACKGROUND: Microsomal epoxide hydrolase (EPHX1) metabolises xenobiotics including polyaromatic hydrocarbons (PAHs).	pahs	110-114	epoxide hydrolase 1	Homo sapiens	12-40
17711870-1	2007	BACKGROUND: Microsomal epoxide hydrolase (EPHX1) metabolises xenobiotics including polyaromatic hydrocarbons (PAHs).	pahs	110-114	epoxide hydrolase 1	Homo sapiens	42-47
17711870-3	2007	The effects of EPHX1 variants may depend upon exposures from tobacco smoke and traffic emissions that contain PAHs as well as variants in other enzymes in the PAH metabolic pathway such as glutathione S-transferase (GST) genes.	pahs	110-114	epoxide hydrolase 1	Homo sapiens	15-20
17711870-4	2007	A study was undertaken to investigate associations of variants in EPHX1, GSTM1, GSTP1 and GSTT1 with asthma and the relationships between asthma, EPHX1 metabolic phenotypes and exposure to sources of PAHs.	pahs	200-204	epoxide hydrolase 1	Homo sapiens	146-151
20876610-7	2011	We show that dioxin-type PAHs activate the endogenous arylhydrocarbon receptor (AhR) signaling pathway in hTERT-EEC in a time-, concentration- and congener-specific manner and that the induction of AhR target genes is modulated by estrogen.	pahs	25-29	aryl hydrocarbon receptor	Homo sapiens	80-83
20876610-7	2011	We show that dioxin-type PAHs activate the endogenous arylhydrocarbon receptor (AhR) signaling pathway in hTERT-EEC in a time-, concentration- and congener-specific manner and that the induction of AhR target genes is modulated by estrogen.	pahs	25-29	telomerase reverse transcriptase	Homo sapiens	106-111
20876610-7	2011	We show that dioxin-type PAHs activate the endogenous arylhydrocarbon receptor (AhR) signaling pathway in hTERT-EEC in a time-, concentration- and congener-specific manner and that the induction of AhR target genes is modulated by estrogen.	pahs	25-29	aryl hydrocarbon receptor	Homo sapiens	198-201
12797905-1	2003	Inhalation of polyaromatic hydrocarbons (PAHs) extracted from diesel exhaust particles (DEP) enhances local (nasal) production of IgE in humans.	pahs	41-45	immunoglobulin heavy constant epsilon	Homo sapiens	130-133
16244358-1	2006	DNA damage caused by benzo[a]pyrene (B[a]P) or other polynuclear hydrocarbons (PAHs) induce p53 protein as a protective measure to eliminate the possibility of mutagenic fixation of the DNA damage.	pahs	79-83	transformation related protein 53, pseudogene	Mus musculus	92-95
15296456-1	2004	Conversion of hydrophobic substrates such as polyaromatic hydrocarbons (PAHs) was studied in aqueous-organic media using transformation of pyrene by cytochrome c.	pahs	72-76	cytochrome c, somatic	Homo sapiens	149-161
17639325-4	2007	The refinery contribution of 11.5%-44.3% PAHs to ambient TSP and 5.5%-18.5% PAHs to ambient RSPM was observed.	pahs	41-45	thrombospondin 1	Homo sapiens	57-60
17639325-5	2007	Non-respirable fraction of ambient TSP near refinery contributed upto 25% PAHs.	pahs	74-78	thrombospondin 1	Homo sapiens	35-38
15919055-10	2005	These results suggest that the inhibitory effects of PAHs on osteoclastogenesis are direct and likely involve interaction of the RANKL and PAH signaling pathways.	pahs	53-57	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	129-134
12381387-3	2002	We performed a comparative study of crab UroD with the enzyme UroD present in Wistar rat liver, which is known as a useful indicator of intoxication by polyhalogenated aromatic hydrocarbons (PAHs).	pahs	191-195	uroporphyrinogen decarboxylase	Rattus norvegicus	41-45
12381387-3	2002	We performed a comparative study of crab UroD with the enzyme UroD present in Wistar rat liver, which is known as a useful indicator of intoxication by polyhalogenated aromatic hydrocarbons (PAHs).	pahs	191-195	uroporphyrinogen decarboxylase	Rattus norvegicus	62-66
10837373-1	2000	Polycyclic aromatic hydrocarbon carcinogens (PAHs) and their metabolites have been found to result in a rapid accumulation of p53 gene product in human and mouse cells.	pahs	45-49	tumor protein p53	Homo sapiens	126-129
12028803-6	2002	Moreover, HO-1 expression was positively correlated to the higher organic carbon (OC) and polyaromatic hydrocarbons (PAHs) content of fine versus coarse PM, as well as the rise in PAH content that occurs in coarse PM during the winter months.	pahs	117-121	heme oxygenase 1	Homo sapiens	10-14
11679243-1	2001	A biosensor for detecting the toxicity of polycylic aromatic hydrocarbons (PAHs) contaminated soil has been successfully constructed using an immobilized recombinant bioluminescent bacterium, GC2 (lac::luxCDABE), which constitutively produces bioluminescence.	pahs	75-79	solute carrier family 25 member 18	Homo sapiens	192-195
10837373-11	2000	We conclude that PAHs-induced p53 protein is transcriptionally active.	pahs	17-21	tumor protein p53	Homo sapiens	30-33
9867872-1	1999	The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife.	pahs	115-119	aryl hydrocarbon receptor	Homo sapiens	4-15
9867872-1	1999	The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife.	pahs	115-119	aryl hydrocarbon receptor	Homo sapiens	17-20