PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2468759-7 1989 The MMC-Dcat pretreatment also affected the uptake of Evans blue (EB) bound to bovine serum albumin (BSA). Evans Blue 54-64 albumin Rattus norvegicus 86-99 2812504-2 1989 In rats with antibodies to CGRP, there was an approximately 50% decrease compared to the control animals in extravasation, measured by the Evans blue method after topical mustard oil. Evans Blue 139-149 calcitonin-related polypeptide alpha Rattus norvegicus 27-31 2539540-0 1989 Evaluation of the effect of evan"s blue and triphenyltetrazolium chloride dyes on myeloperoxidase activity in canine cardiac tissue. Evans Blue 28-39 myeloperoxidase Canis lupus familiaris 82-97 2495841-6 1989 The specific ODC inhibitor alpha-difluoromethylornithine (DFMO) blocked the 1.6 M mannitol-induced increase in ODC activity and the accumulation of polyamines, and concurrently prevented BBB breakdown, monitored by transport of intravenously administered Evans blue and alpha-[3H]aminoisobutyrate into cerebral tissue. Evans Blue 255-265 ornithine decarboxylase 1 Homo sapiens 13-16 2468759-7 1989 The MMC-Dcat pretreatment also affected the uptake of Evans blue (EB) bound to bovine serum albumin (BSA). Evans Blue 66-68 albumin Rattus norvegicus 86-99 3148558-0 1988 Treatment with an LHRH agonist or hCG increases interstitial fluid volume and permeability to Evans blue in the mouse testis. Evans Blue 94-104 hypertrichosis 2 (generalised, congenital) Homo sapiens 34-37 3238010-1 1988 The effect of the potent inflammatory mediator, platelet activating factor (PAF) was studied on the vascular permeability of selected rat tissues using the extravasation of Evans blue dye (EB) as a marker. Evans Blue 173-187 PCNA clamp associated factor Rattus norvegicus 76-79 3238010-1 1988 The effect of the potent inflammatory mediator, platelet activating factor (PAF) was studied on the vascular permeability of selected rat tissues using the extravasation of Evans blue dye (EB) as a marker. Evans Blue 189-191 PCNA clamp associated factor Rattus norvegicus 76-79 3148558-2 1988 hCG, subcutaneously, resulted in an increase in the permeability to intravenously injected Evans blue into the testicular interstitial space and in the volume of testicular interstitial fluid. Evans Blue 91-101 hypertrichosis 2 (generalised, congenital) Homo sapiens 0-3 3401633-7 1988 Paf-induced microvascular leakage, measured by the extravasation of intravenously-injected Evans blue dye, was inhibited in a dose-related fashion in the airways and other tissues by WEB 2086, achieving a maximal inhibitory effect at 10 micrograms kg-1, i.v. Evans Blue 91-101 PCNA clamp associated factor Homo sapiens 0-3 3411290-6 1988 Further ultrastructural studies indicated that fibrin formation, first evident within 30 min of the TNF infusion, led to occlusive thrombi limited to the tumor vascular bed (i.e., not in the normal mouse vasculature) within 2 h and was associated with an 80% reduction in tumor perfusion based on studies with Evans blue. Evans Blue 310-320 tumor necrosis factor Mus musculus 100-103 2837454-5 1988 The tracheal extravasation of Evans blue dye was significantly inhibited (P less than 0.05) in TDI-exposed animals treated with TNF (64.7 +/- 7.5). Evans Blue 30-40 tumor necrosis factor Cavia porcellus 128-131 3112329-12 1987 Significant improvements were noted by DSA, and Evans blue and neutral red dye studies in animals treated with TPA. Evans Blue 48-58 tissue-type plasminogen activator Oryctolagus cuniculus 111-114 2891830-1 1987 A significant inflammatory reaction in the rat conjunctiva followed the subconjunctival injection of synthetic platelet activating factor (PAF) in doses which ranged from 10 ng to 1 microgram, an inflammatory response being evaluated as the increase in both tissue weight and extravasation of Evans blue dye in the conjunctival tissue. Evans Blue 293-307 PCNA clamp associated factor Rattus norvegicus 139-142 3498585-11 1987 It markedly inhibits C3a-induced 3H-serotonin release from platelets in vitro and similarly inhibits the C3a-induced extravasation of Evans blue into the skin in vivo. Evans Blue 134-144 complement C3 Homo sapiens 105-108 6529968-1 1984 The intradermal application of both mouse and bovine nerve growth factor induced dose-dependently increased vascular permeability as indicated by Evans blue extravasation. Evans Blue 146-156 nerve growth factor Bos taurus 53-72 6736994-7 1984 EB staining and haemorrhage appeared in the thalamus (rCBF 10 ml 100 g-1 min-1) as oedema was decreasing. Evans Blue 0-2 CCAAT/enhancer binding protein zeta Rattus norvegicus 54-58 6207787-0 1984 The binding of Evans blue to collagen and elastin in elastic tissue. Evans Blue 15-25 elastin Bos taurus 42-49 6207787-4 1984 The capability of collagen and elastin to bind Evans blue was demonstrated with the isolated proteins; it was shown elastin had a higher affinity to the dye than collagen. Evans Blue 47-57 elastin Bos taurus 31-38 6207787-4 1984 The capability of collagen and elastin to bind Evans blue was demonstrated with the isolated proteins; it was shown elastin had a higher affinity to the dye than collagen. Evans Blue 47-57 elastin Bos taurus 116-123 6182963-4 1982 In the brainstem, EB-labelled neurons staining intensely for AChE were found less frequently, but a few were observed in the nucleus tegmenti pendunculopontis, locus ceruleus, subcerulear region, and reticular formation. Evans Blue 18-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 6368371-6 1984 There were, in addition significant correlations between the systemic and enteric secretion of RMCPII and the enteric accumulation of Evan"s blue. Evans Blue 134-145 mast cell protease 2 Rattus norvegicus 95-101 6693517-3 1984 In acute hypertension, Evans blue extravasations were observed in the occipital cortex and sometimes in the superior colliculus, i.e., the regions which also showed the highest elevations in rCBF. Evans Blue 23-33 CCAAT/enhancer binding protein zeta Rattus norvegicus 191-195 6875604-10 1983 In case of the hippocampus, CA2 pyramidal cells revealed more intense uptake of EB than those of the adjacent fields. Evans Blue 80-82 carbonic anhydrase 2 Oryctolagus cuniculus 28-31 6178820-13 1982 The intradermal injection of neurotensin (0.03-30 p-mole) increased capillary permeability in rats pre-treated intravenously with Evans Blue. Evans Blue 130-140 neurotensin Rattus norvegicus 29-40 7364458-1 1980 Effect of indomethacin on the permeability of blood-brain and blood-csf barriers to Evans blue, bromophenol blue and horseradish peroxidase (HRP) was studied by administering the drug through right internal carotid artery, right external jugular vein and through intraperitoneal route in rats. Evans Blue 84-94 colony stimulating factor 2 Rattus norvegicus 68-71 69390-4 1977 If such animals receive an intravenous or intracardiac injection of a 1% Evans blue solution, there is a strong blue colouring in the place where the bradykinin has been applied. Evans Blue 73-83 kininogen 1 Homo sapiens 150-160 19545-5 1977 Also, fixed platelets adsorbed PAF even in the presence of 1M salt or after treatment with Evans blue. Evans Blue 91-101 PCNA-associated factor Bos taurus 31-34 69390-5 1977 The guinea pigs and the rabbits which had been immunized by bradykinin-azo-protein showed a significant decrease in the local accumulation of the Evans blue-solution,, which must be attributed to the immunologic neutralization of the intradermally injected bradykinin by an anti-bradykinin-antibody. Evans Blue 146-156 kininogen 1 Homo sapiens 60-70 69390-5 1977 The guinea pigs and the rabbits which had been immunized by bradykinin-azo-protein showed a significant decrease in the local accumulation of the Evans blue-solution,, which must be attributed to the immunologic neutralization of the intradermally injected bradykinin by an anti-bradykinin-antibody. Evans Blue 146-156 kininogen 1 Homo sapiens 257-267 69390-5 1977 The guinea pigs and the rabbits which had been immunized by bradykinin-azo-protein showed a significant decrease in the local accumulation of the Evans blue-solution,, which must be attributed to the immunologic neutralization of the intradermally injected bradykinin by an anti-bradykinin-antibody. Evans Blue 146-156 kininogen 1 Homo sapiens 257-267 33979123-4 2021 Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity. Evans Blue 81-91 angiotensin converting enzyme 2 Homo sapiens 176-181 5868552-0 1965 [Evans blue as a diagnostic aid in amyloidosis]. Evans Blue 1-11 activation induced cytidine deaminase Homo sapiens 28-31 33838160-10 2021 Administration of exogenous sonic hedgehog and BQ788 suppressed Evans blue extravasation, an indicator of blood vessel permeability, induced by fluid percussion injury. Evans Blue 64-74 sonic hedgehog Mus musculus 28-42 33838160-11 2021 The effects of BQ788 on fluid percussion injury-induced Evans blue extravasation were reduced by the administration of jervine, a sonic hedgehog inhibitor. Evans Blue 56-66 sonic hedgehog Mus musculus 130-144 19604885-0 1976 Retrograde labeling of central nervous pathways with tritiated or Evans blue-labeled bovine serum albumin. Evans Blue 66-76 albumin Rattus norvegicus 92-105 1239827-0 1975 Evans blue: a specific inhibitor of factor VIII-induced platelet agglutination. Evans Blue 0-10 coagulation factor VIII Bos taurus 36-47 1239827-1 1975 Low concentrations of Evans Blue (less than 1 muM) inhibit the agglutination of formalin-treated platelets by bovine Factor VIII or by human Factor VIII in the presence of the antibiotic ristocetin. Evans Blue 22-32 coagulation factor VIII Bos taurus 117-128 1239827-1 1975 Low concentrations of Evans Blue (less than 1 muM) inhibit the agglutination of formalin-treated platelets by bovine Factor VIII or by human Factor VIII in the presence of the antibiotic ristocetin. Evans Blue 22-32 coagulation factor VIII Bos taurus 141-152 1239827-2 1975 Evans Blue is a specific inhibitor of this reaction and acts by inhibiting the binding of Factor VIII to the platelet surface. Evans Blue 0-10 coagulation factor VIII Bos taurus 90-101 33076718-4 2021 The increase of TGF-beta contents in blood by exogenous TGF-beta injection intraperitoneally decreased Evans blue release into mice ears to the same level as LP22A3 treatment in PCA reaction. Evans Blue 103-113 transforming growth factor alpha Mus musculus 16-24 33076718-4 2021 The increase of TGF-beta contents in blood by exogenous TGF-beta injection intraperitoneally decreased Evans blue release into mice ears to the same level as LP22A3 treatment in PCA reaction. Evans Blue 103-113 transforming growth factor alpha Mus musculus 56-64 33979123-4 2021 Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity. Evans Blue 81-91 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 191-196 33565367-6 2021 Endothelial-specific YAP knockout mice following high VT ventilation exhibited increased neutrophil counts and protein content in bronchoalveolar lavage fluid, Evans blue leakage and histological lung injury compared to wild-type littermate controls. Evans Blue 160-170 yes-associated protein 1 Mus musculus 21-24 34007295-3 2021 The results of the anti-DNP IgE-mediated passive cutaneous anaphylaxis (PCA) showed that GLA dramatically inhibited PCA in vivo, as evidenced by reduced Evans blue extravasation and decreased ear thickness. Evans Blue 153-163 galactosidase, alpha Rattus norvegicus 89-92 33568994-4 2020 In the present study, recombinant human FGF20 (rhFGF20) reduced neurofunctional deficits, brain edema, Evans blue extravasation and neuroinflammation in a TBI mouse model. Evans Blue 103-113 fibroblast growth factor 20 Homo sapiens 40-45 33333175-8 2021 In rat models, up-regulation of miR-26a could attenuate brain water content, Evans blue content, apoptosis, pathological injury and expression of CTGF and Bax, while promoted number of Nissl bodies and expression of miR-26a and Bcl-2 in the nervous cells in brain in ICH rats. Evans Blue 77-87 microRNA 26a Rattus norvegicus 32-39 33309746-6 2021 IL-1beta administration reversed the effect of escin on Garcia test scores, the brain water contents, and the Evans blue extravasation. Evans Blue 110-120 interleukin 1 alpha Mus musculus 0-8 32382851-0 2021 Evans Blue Might Produce Pathologically Activated Neuroprotective Effects via the Inhibition of the P2X4R/p38 Signaling Pathway. Evans Blue 0-10 mitogen-activated protein kinase 14 Mus musculus 106-109 32382851-9 2021 All these results strongly suggested that Evans Blue could exert neuroprotective effects via inhibiting the P2X4R/p38 pathway, possibly by acting on the ATP binding site of P2X4R, indicating that Evans Blue might be further developed as a pathologically activated therapeutic drug against ischemic stroke. Evans Blue 42-52 mitogen-activated protein kinase 14 Mus musculus 114-117 32382851-9 2021 All these results strongly suggested that Evans Blue could exert neuroprotective effects via inhibiting the P2X4R/p38 pathway, possibly by acting on the ATP binding site of P2X4R, indicating that Evans Blue might be further developed as a pathologically activated therapeutic drug against ischemic stroke. Evans Blue 196-206 mitogen-activated protein kinase 14 Mus musculus 114-117 32951103-10 2021 Neurological dysfunction, brain water content, Evans Blue extravasation, microglial activation, and neuronal apoptosis were significantly reduced by GLP-1R agonist liraglutide. Evans Blue 47-57 glucagon-like peptide 1 receptor Rattus norvegicus 149-155 33584203-9 2020 Furthermore, inhibition of caspase-1 enhanced the encapsulation rate of pericytes at the ischemic edge, decreased leakage of both Evans Blue (EB) and matrix metalloproteinase (MMP) proteins, and upregulated the levels of tight junctions (TJs) and tissue inhibitors of metalloproteinases (TIMPs) in MCAO-injured rats. Evans Blue 130-140 caspase 1 Rattus norvegicus 27-36 33081026-6 2020 The Miles assay with an albumin-binding dye Evans Blue revealed that irradiation enhanced vascular permeability. Evans Blue 44-54 albumin Mus musculus 24-31 33164260-4 2021 In the MIRI mouse models and hypoxia/reoxygenation (H/R)-induced cardiomyocyte models, the expression of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 was manipulated to examine their effects on the infarction area, cardiomyocyte viability and apoptosis employing the Evans blue/TTC double staining, CCK-8 and TUNEL assays. Evans Blue 260-270 taurine upregulated gene 1 Mus musculus 105-109 33164260-4 2021 In the MIRI mouse models and hypoxia/reoxygenation (H/R)-induced cardiomyocyte models, the expression of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 was manipulated to examine their effects on the infarction area, cardiomyocyte viability and apoptosis employing the Evans blue/TTC double staining, CCK-8 and TUNEL assays. Evans Blue 260-270 microRNA 340 Mus musculus 110-117 33164260-4 2021 In the MIRI mouse models and hypoxia/reoxygenation (H/R)-induced cardiomyocyte models, the expression of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 was manipulated to examine their effects on the infarction area, cardiomyocyte viability and apoptosis employing the Evans blue/TTC double staining, CCK-8 and TUNEL assays. Evans Blue 260-270 histone deacetylase 4 Mus musculus 118-123 33164260-4 2021 In the MIRI mouse models and hypoxia/reoxygenation (H/R)-induced cardiomyocyte models, the expression of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 was manipulated to examine their effects on the infarction area, cardiomyocyte viability and apoptosis employing the Evans blue/TTC double staining, CCK-8 and TUNEL assays. Evans Blue 260-270 catenin (cadherin associated protein), beta 1 Mus musculus 124-136 33164260-4 2021 In the MIRI mouse models and hypoxia/reoxygenation (H/R)-induced cardiomyocyte models, the expression of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 was manipulated to examine their effects on the infarction area, cardiomyocyte viability and apoptosis employing the Evans blue/TTC double staining, CCK-8 and TUNEL assays. Evans Blue 260-270 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 137-142 33754596-6 2020 RESULTS: Hyperhydration brought about the largest intracellular deposits of EB in CA3 hippocampal region, followed by the cerebral cortex and CA1 hippocampal region with the lowest amount of intracellular EB in the dentate gyrus. Evans Blue 76-78 carbonic anhydrase 3 Rattus norvegicus 82-85 33022015-9 2020 Additionally, Evans blue, a sulfonic acid-containing dye, could be identified as an Mpro inhibitor. Evans Blue 14-24 NEWENTRY Severe acute respiratory syndrome-related coronavirus 84-88 32505355-4 2020 However, after overexpressing TBK1 through an intramyocardial injection of TBK1 adenovirus, TBK1 overexpression improved cardiac function detected by echocardiography, decreased infarct size detected by Evans Blue and TTC staining, reduced cardiomyocyte apoptosis measured by TUNEL staining and alleviated disruption of mitochondria and cardiac muscle fibers detected by TEM in response to MI/R injury. Evans Blue 203-213 TANK binding kinase 1 Homo sapiens 30-34 32341518-5 2020 Using Evans Blue permeation and retention as an indication of increased vascular permeability in vivo, we showed that TRPV4 contributes to PAR1-induced vascular hyperpermeability in the airways and upper gastrointestinal tract of mice. Evans Blue 6-16 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 118-123 32341518-5 2020 Using Evans Blue permeation and retention as an indication of increased vascular permeability in vivo, we showed that TRPV4 contributes to PAR1-induced vascular hyperpermeability in the airways and upper gastrointestinal tract of mice. Evans Blue 6-16 coagulation factor II (thrombin) receptor Mus musculus 139-143 32615180-7 2020 Intravenous administration of the GPR55 agonist to animals that received CYP significantly decreased Evans Blue extravasation and increased urothelium thickness. Evans Blue 101-111 G protein-coupled receptor 55 Rattus norvegicus 34-39 32755305-5 2020 To evaluate vascular permeability of the larynx, Evans blue dye was intravenously injected after 5 or 60 min of sustained TRPV1 activation. Evans Blue 49-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-127 32505355-4 2020 However, after overexpressing TBK1 through an intramyocardial injection of TBK1 adenovirus, TBK1 overexpression improved cardiac function detected by echocardiography, decreased infarct size detected by Evans Blue and TTC staining, reduced cardiomyocyte apoptosis measured by TUNEL staining and alleviated disruption of mitochondria and cardiac muscle fibers detected by TEM in response to MI/R injury. Evans Blue 203-213 TANK binding kinase 1 Homo sapiens 75-79 32505355-4 2020 However, after overexpressing TBK1 through an intramyocardial injection of TBK1 adenovirus, TBK1 overexpression improved cardiac function detected by echocardiography, decreased infarct size detected by Evans Blue and TTC staining, reduced cardiomyocyte apoptosis measured by TUNEL staining and alleviated disruption of mitochondria and cardiac muscle fibers detected by TEM in response to MI/R injury. Evans Blue 203-213 TANK binding kinase 1 Homo sapiens 75-79 32477057-7 2020 Results: Compared with WT mice, Trpv4-/- mice showed reduced ischemia-induced lesion volume and reduced water content and Evans blue leakage in the ipsilateral hemisphere alongside milder neurological symptoms. Evans Blue 122-132 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 32-37 32468886-6 2020 In vivo, using the partial carotid ligation model of disturbed flow, Nck1 knockout prevented the increase in vascular permeability, as assessed by Evans blue and fluorescein isothiocyanate dextran extravasations and leakage of plasma fibrinogen into the vessel wall. Evans Blue 147-157 NCK adaptor protein 1 Homo sapiens 69-73 32276104-9 2020 However, the leakage of Evans Blue was significantly increased in the injured cord of Gli1lz/lz mice compared to wild-type mice. Evans Blue 24-34 GLI-Kruppel family member GLI1 Mus musculus 86-90 32300934-7 2020 The CORM-2-SLN-treated group showed significantly diminished extravasation of Evans Blue dye with enhanced expression of tight junction proteins following SCI. Evans Blue 78-88 sarcolipin Rattus norvegicus 11-14 32086377-4 2020 Intravitreal co-injection of norrin with VEGF completely ablated VEGF-induced BRB permeability to Evans blue-albumin. Evans Blue 98-108 norrin cystine knot growth factor NDP Rattus norvegicus 29-35 32160957-7 2020 The modified neurological severity score, modified limb placing test score, brain water content and evans blue content were reduced after transplanted miR-126-modified MSCs. Evans Blue 100-110 microRNA 126b Rattus norvegicus 151-158 32112918-9 2020 HDAC10 silencing aggravated ICH injury, as demonstrated by increased modified neurological severity scores, brain water content, Evans blue extravasation, and number of myeloperoxidase (MPO) cells, and the results of Nissl and H&E staining. Evans Blue 129-139 histone deacetylase 10 Rattus norvegicus 0-6 31603990-7 2020 Intriguingly, our study showed that the expression of both cystatin C and caveolin-1 was increased in middle cerebral artery occlusion-injured mice, and pretreatment with exogenous cystatin C significantly increased caveolin-1 expression, reduced Evans Blue leakage in the injured brain region, and decreased the enzymatic activity of matrix metallopeptidase-9. Evans Blue 247-257 caveolin 1, caveolae protein Mus musculus 74-84 31603990-7 2020 Intriguingly, our study showed that the expression of both cystatin C and caveolin-1 was increased in middle cerebral artery occlusion-injured mice, and pretreatment with exogenous cystatin C significantly increased caveolin-1 expression, reduced Evans Blue leakage in the injured brain region, and decreased the enzymatic activity of matrix metallopeptidase-9. Evans Blue 247-257 cystatin C Mus musculus 181-191 32086377-4 2020 Intravitreal co-injection of norrin with VEGF completely ablated VEGF-induced BRB permeability to Evans blue-albumin. Evans Blue 98-108 vascular endothelial growth factor A Rattus norvegicus 41-45 32086377-4 2020 Intravitreal co-injection of norrin with VEGF completely ablated VEGF-induced BRB permeability to Evans blue-albumin. Evans Blue 98-108 vascular endothelial growth factor A Rattus norvegicus 65-69 32019570-13 2020 Consistent with the in vitro results, CLEC14A-KO mice that were injected with Evans blue dye had cerebral vascular leakage at postnatal day 8; wild-type mice had no leakage. Evans Blue 78-88 C-type lectin domain family 14, member a Mus musculus 38-45 32226486-4 2020 Furthermore, the quantification of brain water content and the extravasation of Evans blue dye revealed a significant reduction in SAH-induced brain edema and blood-brain barrier permeability at 72 h due to treatment with the calpastatin peptide when compared with untreated SAH controls. Evans Blue 80-94 calpastatin Rattus norvegicus 226-237 31413130-8 2019 Evans blue intensities in WT mouse tissues are significantly higher than in NLRP3-/- mouse tissues, demonstrating an essential role of NLRP3 in M-induced vascular leakages in mice. Evans Blue 0-10 NLR family, pyrin domain containing 3 Mus musculus 135-140 31805065-10 2019 Vascular leakage of Evans blue dye into the lung tissue was also greater in Mertk-/- mice. Evans Blue 20-30 MER proto-oncogene tyrosine kinase Mus musculus 76-81 31478134-8 2020 ANF could significantly reduce the Evans blue extravasation and water content in the ipsilateral hemisphere and obviously increase the occludin, claudin-5, and ZO-1 expression after cerebral I/R injury. Evans Blue 35-45 natriuretic peptide A Rattus norvegicus 0-3 30929532-10 2019 Moreover, perineurial and epineurial EB co-located or overlaid with Lyve1 immuno-reactivity and VEGF antibody, and lymphatic network connected with perivascular spaces or tissues, suggesting lymphatic system-perivascular spaces might involve in the EB delivery with i.d. Evans Blue 37-39 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 68-73 30929532-10 2019 Moreover, perineurial and epineurial EB co-located or overlaid with Lyve1 immuno-reactivity and VEGF antibody, and lymphatic network connected with perivascular spaces or tissues, suggesting lymphatic system-perivascular spaces might involve in the EB delivery with i.d. Evans Blue 37-39 vascular endothelial growth factor A Homo sapiens 96-100 31453815-10 2019 Recombinant thrombomodulin reduced the histologic injury score, expression of tumor necrosis factor-alpha and keratinocyte-derived chemokine, and extravasation of Evans blue dye, which were augmented by 30-min ischemia-reperfusion, in the liver, but not in the intestine. Evans Blue 163-177 thrombomodulin Mus musculus 12-26 30986645-5 2019 Our study also found that EphA2 antagonism significantly decreased the wet/dry ratios, reduced the Evans blue albumin extravasation in lung tissues and obviously alleviated the LPS-induced increment of pulmonary vascular permeability. Evans Blue 99-109 EPH receptor A2 Homo sapiens 26-31 30467816-7 2019 Inhibition of MLCK significantly reduced BBB permeability (Evans Blue extravasation - 28%) and significantly decreased edema formation in comparison with controls (- 2%). Evans Blue 59-69 myosin light chain kinase 3 Mus musculus 14-18 31180722-6 2019 The induced deletion of Zipk significantly inhibited ischemia-reperfusion-induced blood-brain barrier dysfunction and neuronal injuries from middle cerebral artery occlusion and reperfusion, as evidenced by reduced infarct and edema volume, attenuated Evans blue dye leakage, and improved neuronal behavior. Evans Blue 252-262 death-associated protein kinase 3 Mus musculus 24-28 30955191-6 2019 EB content increased at 3 h after the administration of ioversol via the carotid artery and reached a peak at 6 h (P < 0.05), whereas it decreased to its normal level at 24 h. Western blot and immunofluorescence staining indicated that the expression of ZO-1 in brain tissues gradually decreased to its lowest level at 3 h, and then increased gradually, but was still lower than that of the normal control group at 24 h (P < 0.05). Evans Blue 0-2 tight junction protein 1 Rattus norvegicus 257-261 30449147-9 2019 UTI could significantly attenuate blood-brain-barrier (BBB) disruption, as seen through brain edema evaluation and Evans blue content examination. Evans Blue 115-125 alpha-1-microglobulin/bikunin precursor Rattus norvegicus 0-3 30843934-10 2019 Ginsenoside Rb1 reduced extravasation of Evans Blue dye from retinal blood vessels. Evans Blue 41-51 RB transcriptional corepressor 1 Rattus norvegicus 12-15 31024246-11 2019 Transfusion of resting platelets ameliorated tPA-induced loss of cerebrovascular integrity and reduced extravascular accumulation of circulating serum proteins and Evans blue, associated with improved neurological functions after ischemia. Evans Blue 164-174 plasminogen activator, tissue Mus musculus 45-48 31077470-12 2019 To this end, we used Evans Blue dye to demonstrate that elevated prolactin appears to reduce median eminence permeability and also that this effect is lost in animals lacking neuronal prolactin receptors. Evans Blue 21-31 prolactin Mus musculus 65-74 31091226-7 2019 In vivo, syndecan-3 ectodomain fragments increased extravasation of albumin-bound Evans blue in mouse lung, indicative of plasma protein leakage into the surrounding tissue. Evans Blue 82-92 syndecan 3 Mus musculus 9-19 30646866-12 2019 Hemopexin up-regulated HO-1 protein expression, the average vessel density in the penumbra hippocampus and the VE- cadherin expression but decreased the permeability of EB, the water content of brain tissue and the ratio of Ang1/Ang2. Evans Blue 169-171 hemopexin Rattus norvegicus 0-9 31106537-8 2019 In the in vivo experiment of rats, compared with the control group, the mass percent of Evans blue in rat brain tissues increased after A549 cell culture solution with hypoxia 2 h was injected via caudal vein, meaning increased the permeability of rat blood brain barrier, while the expression of Claudin-5 protein in rat brain tissues decreased (all P<0.05). Evans Blue 88-98 claudin 5 Rattus norvegicus 297-306 29569041-9 2019 Evans Blue extravasation and hemoglobin quantification in the ipsilateral hemisphere were greatly reduced, suggesting that TRPM4 inhibition can improve BBB integrity after ischemic stroke reperfusion. Evans Blue 0-10 transient receptor potential cation channel, subfamily M, member 4 Rattus norvegicus 123-128 30618576-5 2018 Anthocyanin could also markedly ameliorate cerebral edema and reduce the concentration of Evans blue (EB) by inhibiting MMP-9. Evans Blue 90-100 matrix metallopeptidase 9 Rattus norvegicus 120-125 30714958-14 2019 Ex-vivo imaging showed higher levels of Evans blue dye in the ApoE-PON1 DKO mice brain tissues, pointing toward impaired vasculature. Evans Blue 40-50 apolipoprotein E Mus musculus 62-66 30422312-5 2019 Concomitantly, HSPB8 over-expression noticeably prevented blood-brain barrier (BBB) disruption after cerebral I/R injury as indicated by the reduction in Evans blue leakage and IgG detection in the ipsilateral hemisphere compared with the vehicle group. Evans Blue 154-164 heat shock protein family B (small) member 8 Rattus norvegicus 15-20 30422312-10 2019 The results showed that 3-MA elicited a significant loss of the protective effect of HSPB8 against MCAO/R-induced neurological defect, Evans blue extravasation, and the loss tight junction proteins, suggesting that the BBB protective role of HSPB8 was, at least in part, mediated through autophagy. Evans Blue 135-145 heat shock protein family B (small) member 8 Rattus norvegicus 85-90 30618576-5 2018 Anthocyanin could also markedly ameliorate cerebral edema and reduce the concentration of Evans blue (EB) by inhibiting MMP-9. Evans Blue 102-104 matrix metallopeptidase 9 Rattus norvegicus 120-125 30105912-0 2018 Single Low-Dose Injection of Evans Blue Modified PSMA-617 Radioligand Therapy Eliminates Prostate-Specific Membrane Antigen Positive Tumors. Evans Blue 29-39 folate hydrolase 1 Homo sapiens 49-53 30105912-0 2018 Single Low-Dose Injection of Evans Blue Modified PSMA-617 Radioligand Therapy Eliminates Prostate-Specific Membrane Antigen Positive Tumors. Evans Blue 29-39 folate hydrolase 1 Homo sapiens 89-123 30105912-5 2018 We postulated that the addition of the Evans blue (EB) moiety to PSMA-617 would improve the PK by extending circulation half-life, which would increase tumor uptake and improve radiotherapeutic efficacy. Evans Blue 39-49 folate hydrolase 1 Homo sapiens 65-69 30105912-5 2018 We postulated that the addition of the Evans blue (EB) moiety to PSMA-617 would improve the PK by extending circulation half-life, which would increase tumor uptake and improve radiotherapeutic efficacy. Evans Blue 51-53 folate hydrolase 1 Homo sapiens 65-69 30105912-6 2018 PSMA-617 was modified by conjugation of a 2-thiol acetate group onto the primary amine and thereafter reacted with a maleimide functional group of an EB derivative, to give EB-PSMA-617. Evans Blue 150-152 folate hydrolase 1 Homo sapiens 0-4 30105912-6 2018 PSMA-617 was modified by conjugation of a 2-thiol acetate group onto the primary amine and thereafter reacted with a maleimide functional group of an EB derivative, to give EB-PSMA-617. Evans Blue 150-152 folate hydrolase 1 Homo sapiens 176-180 30105912-6 2018 PSMA-617 was modified by conjugation of a 2-thiol acetate group onto the primary amine and thereafter reacted with a maleimide functional group of an EB derivative, to give EB-PSMA-617. Evans Blue 173-175 folate hydrolase 1 Homo sapiens 0-4 30105912-6 2018 PSMA-617 was modified by conjugation of a 2-thiol acetate group onto the primary amine and thereafter reacted with a maleimide functional group of an EB derivative, to give EB-PSMA-617. Evans Blue 173-175 folate hydrolase 1 Homo sapiens 176-180 29935233-7 2018 RESULTS: Compared with I/R or I/R + sh-con groups, I/R + sh-RGMa group showed smaller infarction volume, attenuated brain edema, improved neurological scores and better BBB integrity, such as reduced Evans blue leakage and ultra-structural change. Evans Blue 200-210 repulsive guidance molecule BMP co-receptor a Rattus norvegicus 60-64 29573352-3 2018 The results showed that administration of 7.5 mg/kg alpha-HMGB1 1 h after IAV (A/Puerto Rico/8/34) inoculation significantly alleviated brain edema at 48 h after IAV inoculation, as confirmed by the suppression of Evans Blue dye leakage and matrix metallopeptidase-9 mRNA expression in the brain. Evans Blue 214-228 high mobility group box 1 Homo sapiens 58-63 29316834-5 2018 ET-1 and ETB receptors were increased at 2-7 days after FPI, which was accompanied by extravasation of Evans blue (EB) and brain edema. Evans Blue 103-113 endothelin 1 Mus musculus 0-4 29567043-4 2018 Evans blue dye, which selectively binds to blood albumin, was used to monitor the level of inflammation by monitoring vascular permeability in control non-diseased and ligature-induced experimental periodontitis tissue. Evans Blue 0-10 albumin Mus musculus 49-56 29316834-5 2018 ET-1 and ETB receptors were increased at 2-7 days after FPI, which was accompanied by extravasation of Evans blue (EB) and brain edema. Evans Blue 103-113 endothelin receptor type B Mus musculus 9-12 29316834-5 2018 ET-1 and ETB receptors were increased at 2-7 days after FPI, which was accompanied by extravasation of Evans blue (EB) and brain edema. Evans Blue 115-117 endothelin 1 Mus musculus 0-4 29316834-5 2018 ET-1 and ETB receptors were increased at 2-7 days after FPI, which was accompanied by extravasation of Evans blue (EB) and brain edema. Evans Blue 115-117 endothelin receptor type B Mus musculus 9-12 29567043-5 2018 More specifically, leakage of Evans blue-bound albumin from the micro-capillary to connective tissue indicates the state of inflammation occurring in the specific site. Evans Blue 30-40 albumin Mus musculus 47-54 29522856-10 2018 In vivo studies indicate that PAF increased the BBB permeability, assessed with sodium fluorescein and Evans Blue methods, via PAF receptor-dependent mechanisms, consequent to Ca2+ influx and increased NO levels. Evans Blue 103-113 PCNA clamp associated factor Rattus norvegicus 30-33 29522856-10 2018 In vivo studies indicate that PAF increased the BBB permeability, assessed with sodium fluorescein and Evans Blue methods, via PAF receptor-dependent mechanisms, consequent to Ca2+ influx and increased NO levels. Evans Blue 103-113 PCNA clamp associated factor Rattus norvegicus 127-130 29547524-6 2018 The myocardial infarct area/area at risk (IA/AAR), evaluated using Evans blue (EB) and 2,3,5-triphenyltetrazolium chloride (TTC) staining, was significantly smaller in SeP KO mice than in WT mice. Evans Blue 67-77 selenoprotein P Mus musculus 168-171 29291402-9 2018 Knockdown of CHOP decreased the brain water content, reduced Evans blue extravasation, and improved neurological functions. Evans Blue 61-71 DNA-damage inducible transcript 3 Rattus norvegicus 13-17 29547524-6 2018 The myocardial infarct area/area at risk (IA/AAR), evaluated using Evans blue (EB) and 2,3,5-triphenyltetrazolium chloride (TTC) staining, was significantly smaller in SeP KO mice than in WT mice. Evans Blue 79-81 selenoprotein P Mus musculus 168-171 29253192-4 2018 Conclusions: By analyzing Evans blue extravasation in vivo, we showed that the interaction between SsPepO and human fibronectin significantly increased permeability of the blood-brain barrier. Evans Blue 26-36 fibronectin 1 Homo sapiens 116-127 29274317-11 2018 When administered topically 24 h before antigen challenge, Evans blue leakage and paw swelling were induced in the SSA-treated group and the vehicle group. Evans Blue 59-69 tripartite motif containing 21 Homo sapiens 115-118 29452577-11 2018 Compared to Poldip2+/+ mice, Poldip2+/- animals exhibited decreased Evans blue dye extravasation and improved survival 24 h following stroke. Evans Blue 68-82 polymerase (DNA-directed), delta interacting protein 2 Mus musculus 29-36 29408288-9 2018 In addition, resistin (400 ng/mouse) significantly decreased brain edema (p < 0.001), evans blue (EB) leakage (p < 0.05), MDA content (p < 0.005), apoptotic cells and apoptosis-related proteins (p < 0.001). Evans Blue 89-99 resistin Mus musculus 13-21 29408288-9 2018 In addition, resistin (400 ng/mouse) significantly decreased brain edema (p < 0.001), evans blue (EB) leakage (p < 0.05), MDA content (p < 0.005), apoptotic cells and apoptosis-related proteins (p < 0.001). Evans Blue 101-103 resistin Mus musculus 13-21 29203865-3 2017 By conjugating molecular vaccines with Evans blue (EB) into albumin-binding vaccines (AlbiVax), here we develop clinically promising albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient vaccine delivery and potent cancer immunotherapy. Evans Blue 39-49 albumin Homo sapiens 133-140 29309764-11 2018 Evans blue dye and fluorescent lymphangiography revealed an enhanced lymphatic drainage function in apelin-treated mice. Evans Blue 0-10 apelin Homo sapiens 100-106 29056364-4 2018 At 3days after injury, the permeability of spinal cord-blood-barrier, measured by extravasation of Evans blue dye, was significantly increased in apoE-/- mice compared to wild type. Evans Blue 99-109 apolipoprotein E Mus musculus 146-150 29203865-3 2017 By conjugating molecular vaccines with Evans blue (EB) into albumin-binding vaccines (AlbiVax), here we develop clinically promising albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient vaccine delivery and potent cancer immunotherapy. Evans Blue 39-49 albumin Homo sapiens 133-140 29203865-3 2017 By conjugating molecular vaccines with Evans blue (EB) into albumin-binding vaccines (AlbiVax), here we develop clinically promising albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient vaccine delivery and potent cancer immunotherapy. Evans Blue 51-53 albumin Homo sapiens 60-67 29203865-3 2017 By conjugating molecular vaccines with Evans blue (EB) into albumin-binding vaccines (AlbiVax), here we develop clinically promising albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient vaccine delivery and potent cancer immunotherapy. Evans Blue 51-53 albumin Homo sapiens 133-140 29203865-3 2017 By conjugating molecular vaccines with Evans blue (EB) into albumin-binding vaccines (AlbiVax), here we develop clinically promising albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient vaccine delivery and potent cancer immunotherapy. Evans Blue 51-53 albumin Homo sapiens 133-140 29207644-8 2017 We further confirm the protective role of simvastatin on vascular leakage in the heart of diabetic rats injected with Evans blue dye, which was associated with HMGB1 release in the serum. Evans Blue 118-128 high mobility group box 1 Rattus norvegicus 160-165 28930962-11 2017 Adjuvant treatment with C23 also decreased the lung histology score by 33.9%, lung extravasation of albumin carrying Evans blue dye by 36.8%, and the protein level of intercellular adhesion molecule-1, and indicator of vascular endothelial cell activation, by 40.3%. Evans Blue 117-127 nucleolin Mus musculus 24-27 28629822-6 2017 Intramuscular injection of AAV-Nano-Dysferlin in young dysferlin-deficient mice significantly improved muscle integrity and decreased muscle turnover 3 weeks after treatment, as determined by Evans blue dye uptake and central nucleated fibers, respectively. Evans Blue 192-206 dysferlin Mus musculus 36-45 28698029-8 2017 Knockdown of EphA4 using EphA4 siRNA injection intracerebroventricularly (i.c.v) reduced Evans blue extravasation, decreased brain water content, and alleviated neurobehavioral dysfunction after SAH. Evans Blue 89-99 Eph receptor A4 Rattus norvegicus 13-18 28698029-8 2017 Knockdown of EphA4 using EphA4 siRNA injection intracerebroventricularly (i.c.v) reduced Evans blue extravasation, decreased brain water content, and alleviated neurobehavioral dysfunction after SAH. Evans Blue 89-99 Eph receptor A4 Rattus norvegicus 25-30 28625919-5 2017 Vascular permeability to Evans blue dye was notably enhanced in CTRP1 knockin mice as compared to wild type animals, whereas aortic hyper-permeability at disturbed sites was remarkably restored after deletion of CTRP1. Evans Blue 25-35 C1q and tumor necrosis factor related protein 1 Mus musculus 64-69 28637776-8 2017 Although there was no significant difference in the area at risk, the area of vital myocardium was markedly larger in mice treated with RNase-1 compared with controls, as detected by Evans blue and 2,3,5-triphenyltetrazolium chloride staining. Evans Blue 183-193 ribonuclease, RNase A family, 1 (pancreatic) Mus musculus 136-143 28270193-11 2017 More SP and CGRP positive nerve fibers were distributed in EB dots than that in regions beside EB dots and in the control, mostly distributed in the nerve fibers around both the vessels and root of hair follicle. Evans Blue 59-61 calcitonin-related polypeptide alpha Rattus norvegicus 12-16 27995357-12 2017 In vivo, Evans blue dye accumulation was higher in the lungs of BMP4-treated C57BL/6 mice compared to controls indicating that BMP4 increased vascular permeability. Evans Blue 9-23 bone morphogenetic protein 4 Mus musculus 64-68 27995357-12 2017 In vivo, Evans blue dye accumulation was higher in the lungs of BMP4-treated C57BL/6 mice compared to controls indicating that BMP4 increased vascular permeability. Evans Blue 9-23 bone morphogenetic protein 4 Mus musculus 127-131 28341661-9 2017 In streptozotocin (STZ)-induced diabetes, there was an increase in Evans Blue extravasation after both 1 and 8 weeks of diabetes, which was reduced upon intravitreal and systemic delivery of recombinant human (rh)VEGF-A165b. Evans Blue 67-77 vascular endothelial growth factor A Homo sapiens 213-217 28493916-6 2017 In cultured NPCs, inhibition of VGLUT by Evans Blue increased the mRNA level of neuronal markers doublecortin, B3T and MAP2, elevated the number of NPCs expressing doublecortin protein and promoted the number of cells with morphological appearance of branched neurons, suggesting that VGLUT function prevents neuronal differentiation of NPCs. Evans Blue 41-51 microtubule associated protein 2 Homo sapiens 119-123 27916423-5 2017 In the ulinastatin treatment group, the area of EB staining was significantly smaller, the exudation of EB decreased significantly after cerebral ischemia/reperfusion at 6h, 24h, 48h, compared to the model group at corresponding time points (P<0.05) but increased compared to the sham group. Evans Blue 48-50 alpha-1-microglobulin/bikunin precursor Rattus norvegicus 7-18 27916423-5 2017 In the ulinastatin treatment group, the area of EB staining was significantly smaller, the exudation of EB decreased significantly after cerebral ischemia/reperfusion at 6h, 24h, 48h, compared to the model group at corresponding time points (P<0.05) but increased compared to the sham group. Evans Blue 104-106 alpha-1-microglobulin/bikunin precursor Rattus norvegicus 7-18 27951701-5 2016 The UTMs represented selective adsorption behaviors toward hydrophilic dyes even with similar backbones and the same charge states, namely, they showed high adsorption capacities (Qeq) toward eosin B, erythrosin B (ETB), 4",5"-dibromofluorescein, and Evans blue (EVB) dyes up to 300 mumol/g while showing low adsorption capacities toward calcein (Cal), methyl red, and Ponceau S dyes. Evans Blue 251-261 endothelin receptor type B Homo sapiens 215-218 27951701-5 2016 The UTMs represented selective adsorption behaviors toward hydrophilic dyes even with similar backbones and the same charge states, namely, they showed high adsorption capacities (Qeq) toward eosin B, erythrosin B (ETB), 4",5"-dibromofluorescein, and Evans blue (EVB) dyes up to 300 mumol/g while showing low adsorption capacities toward calcein (Cal), methyl red, and Ponceau S dyes. Evans Blue 263-266 endothelin receptor type B Homo sapiens 215-218 27929421-6 2016 Ghrelin reduced ICH-induced intestinal permeability according to fluorescein isothiocyanate conjugated-dextran (FITC-D) and Evans blue extravasation assays. Evans Blue 124-134 ghrelin Mus musculus 0-7 27463015-5 2016 Moreover, Apoe-/- mice exhibited more severe BBB disruption charcteristics after SAH than WT mice, including higher levels of Evans blue and IgG extravasation, T2 hyperintensity in magnetic resonance imaging, tight junction proteins degradation and endothelial cells death. Evans Blue 126-136 apolipoprotein E Mus musculus 10-14 27437607-5 2016 After 5h DEX treatment in vivo, myofibers of Cx43(fl/fl)Cx45(fl/fl) mice showed Evans blue uptake, which was absent in myofibers of Cx43(fl/fl)Cx45(fl/fl):Myo-Cre mice. Evans Blue 80-90 gap junction protein, alpha 1 Mus musculus 45-49 27437607-5 2016 After 5h DEX treatment in vivo, myofibers of Cx43(fl/fl)Cx45(fl/fl) mice showed Evans blue uptake, which was absent in myofibers of Cx43(fl/fl)Cx45(fl/fl):Myo-Cre mice. Evans Blue 80-90 gap junction protein, gamma 1 Mus musculus 56-60 27682195-0 2016 Albumin-Binding Evans Blue Derivatives for Diagnostic Imaging and Production of Long-Acting Therapeutics. Evans Blue 16-26 albumin Homo sapiens 0-7 27682195-3 2016 Evans Blue (EB) dye reversibly binds to serum albumin with moderate affinity and has a long blood half-life. Evans Blue 0-10 albumin Homo sapiens 46-53 27682195-3 2016 Evans Blue (EB) dye reversibly binds to serum albumin with moderate affinity and has a long blood half-life. Evans Blue 12-14 albumin Homo sapiens 46-53 26414212-5 2016 Using an in vivo bTBI model, systemic administration of sodium fluorescein (NaFl; 376 Da), Evans blue (EB; 69 kDa when bound to serum albumin), and dextrans (3-500 kDa) was used to estimate the pore size of BBB opening and the time required for recovery. Evans Blue 103-105 albumin Mus musculus 128-141 27283776-7 2016 After treatment with anti-CKLF1 antibody, brain water content and Evans blue leakage in ipsilateral hemisphere were decreased in a dose-dependent manner at 24h after reperfusion, but not changed in contralateral hemisphere. Evans Blue 66-76 chemokine-like factor Rattus norvegicus 26-31 27158855-9 2016 Moreover, the diminished amounts of Evans blue in homogeneous lung parenchyma in vivo indicated, in comparison with MSCs-GFP, that MSCs-EP2 significantly decreased LPS-induced pulmonary vascular permeability. Evans Blue 36-46 prostaglandin E receptor 2 Homo sapiens 136-139 27018215-4 2016 AQP4 dependent BRB properties were evaluated by measuring the number of extravasations in WT and AQP4 KO retinas by Evans blue injection assay. Evans Blue 116-126 aquaporin 4 Mus musculus 0-4 26993226-4 2016 Naive Timp3(-/-) mice had significantly higher basal pulmonary microvascular Evans blue (EB) dye-labeled albumin leak vs. wild-type (WT) mice. Evans Blue 89-91 tissue inhibitor of metalloproteinase 3 Mus musculus 6-11 26993226-6 2016 Similarly, PBS-treated isolated MVEC monolayers from Timp3(-/-) mice displayed permeability barrier dysfunction vs. WT MVEC, evidenced by lower transendothelial electrical resistance and greater trans-MVEC flux of fluorescein-dextran and EB-albumin. Evans Blue 238-240 tissue inhibitor of metalloproteinase 3 Mus musculus 53-58 27018013-4 2016 By assessing extravasation of Evans blue into the ischemic hemisphere as well as brain edema following MCAO, we further showed that a tPA-exacerbated BBB disruption was significantly ameliorated by the co-administration of ADT-OH. Evans Blue 30-40 plasminogen activator, tissue Mus musculus 134-137 26463959-6 2016 Evans blue dye extravasation (BBB permeability) was quantified 24 h post-nHI, and brain edema at 48 h. Increased BBB permeability and brain edema following nHI was ameliorated in the OPN treatment group. Evans Blue 0-14 secreted phosphoprotein 1 Rattus norvegicus 183-186 27002329-12 2016 5-MTP significantly prevented Evans blue dye leakage. Evans Blue 30-44 solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus 2-5 26937017-7 2016 The administration of exogenous IL-1beta and TNF-alpha to brain-injured animals worsened Evans Blue dye extravasation, suggesting that systemic inflammation contributes to TBI-triggered BBB permeability. Evans Blue 89-103 interleukin 1 beta Homo sapiens 32-40 26937017-7 2016 The administration of exogenous IL-1beta and TNF-alpha to brain-injured animals worsened Evans Blue dye extravasation, suggesting that systemic inflammation contributes to TBI-triggered BBB permeability. Evans Blue 89-103 tumor necrosis factor Homo sapiens 45-54 26670094-6 2016 In addition, ApoJ treatment was shown to suppress the inflammatory response (glial activation, cytokine expression), blood-brain barrier disruption (Evans blue extravasation), and cerebral edema (water content) induced by CCI. Evans Blue 149-159 clusterin Mus musculus 13-17 26534974-9 2015 Either intravenous or intra-arterial delivery of MMP-12 shRNA-expressing plasmid significantly reduced the percent Evans blue dye extravasation and infarct size. Evans Blue 115-129 matrix metallopeptidase 12 Rattus norvegicus 49-55 26556536-4 2016 IGF-I also reduces transfer of Evans blue dye to the brain, suggesting that this peptide may also promote blood-brain barrier function. Evans Blue 31-41 insulin-like growth factor 1 Rattus norvegicus 0-5 26136879-9 2015 IL-6 was also observed to support the integrity of the BBB by reducing Evans blue leakage in vivo and suppressing the expression of matrix metalloproteinase-9 in ischemic brain tissue. Evans Blue 71-81 interleukin 6 Rattus norvegicus 0-4 26441928-4 2015 Measurement of the permeability to Lucifer yellow in vitro and Evans blue extravasation in vivo show that the MRP-hFg interaction significantly increases the permeability of the blood-brain barrier (BBB). Evans Blue 63-73 ATP binding cassette subfamily C member 1 Homo sapiens 110-113 26147204-8 2015 PLAT was isolated for the determination of Evans Blue extravasation (permeability), cytokine content, and immunohistochemistry for inflammatory cell infiltration at 30 minutes and 24 hours after alcohol administration. Evans Blue 43-53 plasminogen activator, tissue type Rattus norvegicus 0-4 26147204-9 2015 RESULTS: PLAT isolated from AAI animals had greater Evans Blue concentrations and cytokine expression (24 hours post-AAI) and mast cell and neutrophil density than that isolated from controls. Evans Blue 52-62 plasminogen activator, tissue type Rattus norvegicus 9-13 25700221-5 2015 Our results showed that exogenous PEDF induced vascular hyperpermeability, as measured by extravasation of Evan"s Blue (EB), dextran and microspheres in the skin, blood, trachea and cremaster muscle, both in a normal state and under conditions of sepsis. Evans Blue 107-118 patatin like phospholipase domain containing 2 Homo sapiens 34-38 25700221-5 2015 Our results showed that exogenous PEDF induced vascular hyperpermeability, as measured by extravasation of Evan"s Blue (EB), dextran and microspheres in the skin, blood, trachea and cremaster muscle, both in a normal state and under conditions of sepsis. Evans Blue 120-122 patatin like phospholipase domain containing 2 Homo sapiens 34-38 26059793-8 2015 Then we found Src kinase inhibitor PP2 could attenuate Evans blue dye extravasation and inhibit the caveolin-1, MMP-9 activation, occludin down-expression after I/R, respectively. Evans Blue 55-65 neuropeptide Y receptor Y6 Mus musculus 35-38 25936678-10 2015 TM significantly decreased brain water content and Evans Blue content, alleviated brain edema and neurological deficits after SAH. Evans Blue 51-61 thrombomodulin Mus musculus 0-2 25972451-5 2015 The mNPT3-mediated PAH uptake was inhibited by 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDs) and Evans blue, common inhibitors of SLC17 family members. Evans Blue 107-117 solute carrier family 17 (sodium phosphate), member 2 Mus musculus 4-9 25864799-3 2015 (2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a pretreatment with either L-732138, a selective antagonist of neurokinin type 1 (NK-1) receptor, or formoterol, a selective agonist of beta2 adrenoceptor. Evans Blue 32-42 tachykinin receptor 1 Rattus norvegicus 161-194 25864799-3 2015 (2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a pretreatment with either L-732138, a selective antagonist of neurokinin type 1 (NK-1) receptor, or formoterol, a selective agonist of beta2 adrenoceptor. Evans Blue 32-42 adrenoceptor beta 2 Rattus norvegicus 234-252 25774662-6 2015 Expression levels of the proinflammatory genes for IL-6, IFN-gamma, TNF-alpha were higher in EB-stained cysts compared to clear cysts and unaffected brain tissues, and were generally highest at 120 hr. Evans Blue 93-95 interleukin 6 Sus scrofa 51-55 25914628-5 2015 We found that the brain water content and Evans blue extravasation at 48 h post-MCAO were reduced by a TRPV4 antagonist HC-067047. Evans Blue 42-52 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 103-108 25774662-6 2015 Expression levels of the proinflammatory genes for IL-6, IFN-gamma, TNF-alpha were higher in EB-stained cysts compared to clear cysts and unaffected brain tissues, and were generally highest at 120 hr. Evans Blue 93-95 interferon gamma Sus scrofa 57-66 25704889-4 2015 This fluoresence was quenched after Evans blue (EB) inhibitor or HIV-1 gp120 protein binding, presumably as a consequence of changes in the distance and dipole orientation between the donor and acceptor; the emission intensity at 420nm decreased in a concentration-dependent fashion. Evans Blue 36-46 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 71-76 25774662-6 2015 Expression levels of the proinflammatory genes for IL-6, IFN-gamma, TNF-alpha were higher in EB-stained cysts compared to clear cysts and unaffected brain tissues, and were generally highest at 120 hr. Evans Blue 93-95 tumor necrosis factor Sus scrofa 68-77 25704889-4 2015 This fluoresence was quenched after Evans blue (EB) inhibitor or HIV-1 gp120 protein binding, presumably as a consequence of changes in the distance and dipole orientation between the donor and acceptor; the emission intensity at 420nm decreased in a concentration-dependent fashion. Evans Blue 48-50 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 71-76 25774662-7 2015 Additionally, expression of some markers of immunoregulatory activity (IL-10, IL-2Ralpha) were decreased in EB-stained capsules. Evans Blue 108-110 IL10 Sus scrofa 71-76 25774662-7 2015 Additionally, expression of some markers of immunoregulatory activity (IL-10, IL-2Ralpha) were decreased in EB-stained capsules. Evans Blue 108-110 interleukin 2 receptor subunit alpha Sus scrofa 78-88 25633836-6 2015 Histochemical analysis using Evan"s Blue, triphenyl-tetrazolium chloride and TUNEL staining, demonstrated that myocardial injury and cardiomyocyte apoptosis induced I/R injury were significantly attenuated in PHD3 knockout mice. Evans Blue 29-40 egl-9 family hypoxia-inducible factor 3 Mus musculus 209-213 25324681-11 2014 The retinal telangiectatic vessels, basement membrane thickness, and Evans blue dye permeability were attenuated by treatment with GPR91 shRNA. Evans Blue 69-83 succinate receptor 1 Rattus norvegicus 131-136 25550365-9 2015 Exogenous Norrin treatment significantly alleviated neurobehavioral dysfunction, reduced brain water content and Evans blue extravasation, promoted beta-catenin nuclear translocation, and increased Occludin, VE-Cadherin, and ZO-1 expressions. Evans Blue 113-123 norrin cystine knot growth factor NDP Rattus norvegicus 10-16 25289042-4 2014 In the present study, TPH2-knockout mice were utilized in the assessment of BBB disruption, as measured by the Evans Blue (EB) extravasation or fluorescein isothiocyanate-albumin leakage assay in the brain. Evans Blue 111-121 tryptophan hydroxylase 2 Mus musculus 22-26 25289042-4 2014 In the present study, TPH2-knockout mice were utilized in the assessment of BBB disruption, as measured by the Evans Blue (EB) extravasation or fluorescein isothiocyanate-albumin leakage assay in the brain. Evans Blue 123-125 tryptophan hydroxylase 2 Mus musculus 22-26 24762637-1 2014 Highly diluted solutions of Gentian Violet and Evans Blue were used to visualize the elastin network in viable porcine right common carotid artery (RCCA) preparations. Evans Blue 47-57 elastin Homo sapiens 85-92 25456115-16 2015 Additionally, CLP led to endothelial injury as determined by electron microscopy and Evans blue dye extravasation, and AICAR limited this injury. Evans Blue 85-99 hyaluronan and proteoglycan link protein 1 Mus musculus 14-17 24724610-8 2014 Evaluation of two NF-kappaB inhibitors, Evans Blue and dehydroxymethylepoxyquinomicin ([-]-DHMEQ), was carried out using p50 and p52 (another form of NF-kappaB), and IC50 values were obtained. Evans Blue 40-50 nuclear factor kappa B subunit 2 Homo sapiens 129-132 24370951-3 2014 HGF decreased the permeability of RBEC to sodium fluorescein and Evans blue albumin, and dose-dependently increased transendothelial electrical resistance (TEER) in RBEC. Evans Blue 65-75 hepatocyte growth factor Rattus norvegicus 0-3 24523141-2 2014 In the rat C6 glioma model, the extravasation of Evans blue (EB) through the BTB was increased significantly by VEGF and PA. Evans Blue 49-59 vascular endothelial growth factor A Rattus norvegicus 112-116 24523141-2 2014 In the rat C6 glioma model, the extravasation of Evans blue (EB) through the BTB was increased significantly by VEGF and PA. Evans Blue 61-63 vascular endothelial growth factor A Rattus norvegicus 112-116 24370951-5 2014 In contrast, HGF increased sodium fluorescein and Evans blue albumin permeability in HMVEC and HUVEC, and decreased TEER in HMVEC. Evans Blue 50-60 hepatocyte growth factor Rattus norvegicus 13-16 24516666-6 2014 Septic pulmonary microvascular Evans blue (EB)-labeled albumin leak was associated with an increased number of PI-positive cells, which were confirmed to be predominantly MVEC based on specific labeling with three markers, anti-CD31 (PECAM), anti-CD34, and lectin binding. Evans Blue 43-45 platelet/endothelial cell adhesion molecule 1 Mus musculus 228-232 24572254-6 2014 Mice lacking dysferlin had a significant 39% lower LV developed pressure, a 20% greater CK release, and 29% greater Evans blue dye uptake after I/R, compared to wild-type mice, thus phenocopying the response to tissue injury in the MHC-TRAF2DN mice. Evans Blue 119-129 dysferlin Mus musculus 13-22 24551038-9 2014 Evans blue fluorescence intensity was higher in the parenchyma and lower in the cerebrovasculature of VEGF-treated animals compared to controls. Evans Blue 0-10 vascular endothelial growth factor A Mus musculus 102-106 24516666-6 2014 Septic pulmonary microvascular Evans blue (EB)-labeled albumin leak was associated with an increased number of PI-positive cells, which were confirmed to be predominantly MVEC based on specific labeling with three markers, anti-CD31 (PECAM), anti-CD34, and lectin binding. Evans Blue 43-45 platelet/endothelial cell adhesion molecule 1 Mus musculus 234-239 24516666-6 2014 Septic pulmonary microvascular Evans blue (EB)-labeled albumin leak was associated with an increased number of PI-positive cells, which were confirmed to be predominantly MVEC based on specific labeling with three markers, anti-CD31 (PECAM), anti-CD34, and lectin binding. Evans Blue 43-45 CD34 antigen Mus musculus 247-251 24788224-7 2014 During EAE, our results show that lack of ApoE increased the Evan"s blue (EB) permeability of BBB. Evans Blue 61-72 apolipoprotein E Mus musculus 42-46 24466134-9 2014 Sacrifice experiments showed that the effect of Ang-2 was accompanied by decrease of the penetration of Evans Blue in the embryos and by increase of its penetration in maternal tissues. Evans Blue 104-114 angiopoietin 2 Homo sapiens 48-53 24788224-7 2014 During EAE, our results show that lack of ApoE increased the Evan"s blue (EB) permeability of BBB. Evans Blue 74-76 apolipoprotein E Mus musculus 42-46 23597848-3 2013 In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Evans Blue 138-148 albumin Rattus norvegicus 94-101 24043768-2 2013 Here, we show that denervation-induced Evans blue dye uptake in vivo of fast, but not slow, myofibers was acutely inhibited by connexin (Cx) hemichannel/pannexin1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers. Evans Blue 39-49 LOC100128922 Homo sapiens 127-135 23937199-8 2013 Inhibitor of iNOS activity suppressed the loss of laminin, leakage of FITC-labeled dextran and Evans blue, and activation of MMP-2 and -13. Evans Blue 95-105 nitric oxide synthase 2 Rattus norvegicus 13-17 24043768-2 2013 Here, we show that denervation-induced Evans blue dye uptake in vivo of fast, but not slow, myofibers was acutely inhibited by connexin (Cx) hemichannel/pannexin1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers. Evans Blue 39-49 LOC100128922 Homo sapiens 137-139 24043768-2 2013 Here, we show that denervation-induced Evans blue dye uptake in vivo of fast, but not slow, myofibers was acutely inhibited by connexin (Cx) hemichannel/pannexin1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers. Evans Blue 39-49 pannexin 1 Homo sapiens 153-162 24043768-2 2013 Here, we show that denervation-induced Evans blue dye uptake in vivo of fast, but not slow, myofibers was acutely inhibited by connexin (Cx) hemichannel/pannexin1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers. Evans Blue 39-49 pannexin 1 Homo sapiens 164-169 24043768-2 2013 Here, we show that denervation-induced Evans blue dye uptake in vivo of fast, but not slow, myofibers was acutely inhibited by connexin (Cx) hemichannel/pannexin1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers. Evans Blue 39-49 purinergic receptor P2X 7 Homo sapiens 205-218 24043768-2 2013 Here, we show that denervation-induced Evans blue dye uptake in vivo of fast, but not slow, myofibers was acutely inhibited by connexin (Cx) hemichannel/pannexin1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers. Evans Blue 39-49 purinergic receptor P2X 7 Homo sapiens 220-225 23868941-7 2013 Evans blue staining of the injured vessel revealed that administration of iPS cell-derived Flk-1(+) significantly enhanced reendothelialization compared with the Flk-1(-) cell control group. Evans Blue 0-10 kinase insert domain protein receptor Mus musculus 91-96 23859306-4 2013 METHODS: The roles of GEF-H1 signaling pathway in LPS-induced ECs barrier dysfunction were accessed by Evans blue dye-labeled albumin (EB-albumin) leak across the human umbilical vein EC (HUVEC) monolayers and Western blot assays. Evans Blue 103-117 Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens 22-28 23724987-9 2013 The inhibitory effects of PPT+DPN on brain water content, neurological scores, and Evans blue dye content were the highest for all groups. Evans Blue 83-97 tachykinin, precursor 1 Rattus norvegicus 26-33 23876310-7 2013 We also found that inhibition of VNUT function by Evans Blue decreased ATP uptake into secretory lysosomes. Evans Blue 50-60 solute carrier family 17 member 9 Homo sapiens 33-37 23638963-5 2013 RESULTS: PDCD5 siRNA reduced the infarct volume, improved neurological deficits, improved cerebral blood flow (CBF), and reduced Evans blue extravasation. Evans Blue 129-139 programmed cell death 5 Homo sapiens 9-14 22689825-6 2012 Vessels in tsad(-/-) mice showed undisturbed flow and pressure, but impaired VEGF-induced permeability, as measured by extravasation of Evans blue, dextran, and microspheres in the skin and the trachea. Evans Blue 136-146 SH2 domain containing 2A Mus musculus 11-15 23637989-4 2013 To identify such cellular biomarkers for BBB injuries, our studies have shown that mice treated with nicotine, METH and gp120 resulted in increased blood levels of CD146+(endothelial marker)/S100B+ (brain marker) circulating BMECs (cBMECs) and CD133+[progenitor cell (PC) marker]/CD146+ endothelial PCs (EPCs), along with enhanced Evans blue and albumin extravasation into the brain. Evans Blue 331-341 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 120-125 23385154-6 2013 SPC-54 decreased lung perfusion in this model by 54% when monitored by vascular perfusion methodologies using infrared fluorescence of Evans blue dye. Evans Blue 135-149 sparse coat Mus musculus 0-3 23254199-8 2013 Moreover, acute pharmacologic blockade of VNUT with Evans blue, a VNUT antagonist, greatly attenuated GSIS in a dose-dependent manner. Evans Blue 52-62 solute carrier family 17, member 9 Mus musculus 42-46 23254199-8 2013 Moreover, acute pharmacologic blockade of VNUT with Evans blue, a VNUT antagonist, greatly attenuated GSIS in a dose-dependent manner. Evans Blue 52-62 solute carrier family 17, member 9 Mus musculus 66-70 23662182-6 2013 Furthermore, cell permeable C2 ceramide, an inhibitor of PLD but not the C2 dihydroceramide, attenuated the H2O2-induced PLD activation and enhancement of paracellular permeability of Evans blue conjugated albumin across the BPAEC monolayers. Evans Blue 184-194 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 23393392-5 2013 Kidney, lung, and brain were the organs with highest discriminative increased Evans Blue accumulation in EPCR(low) versus control mice in response to lipopolysaccharides. Evans Blue 78-88 protein C receptor, endothelial Mus musculus 105-109 22528507-10 2012 Conversely, anti-VEGF treatment significantly reduced tumor vascular permeability to Evans Blue Dye by 45.0 % (p = 0.0012), and anti-VEGF therapy decreased T84.66 tumor AUC((0-10 days)) by more than 60 % (7.27 x 10(2) +- 51.4 vs. 1.98 x 10(3) +- 90.1 nM x day, p < 0.0001). Evans Blue 85-99 vascular endothelial growth factor A Mus musculus 17-21 22372856-8 2012 Polyphosphate also increased the extravasation of the bovine serum albumin (BSA)-bound Evans blue dye and the migration of leukocytes to the mouse peritoneal cavity, which was prevented when activated protein C (APC) was intravenously (i.v.) Evans Blue 87-97 albumin Mus musculus 61-74 22773936-7 2012 NRG1 administered by tail-vein injection 10 minutes after CCI resulted in a decrease in Evans blue dye extravasation by 35%. Evans Blue 88-102 neuregulin 1 Rattus norvegicus 0-4 21937264-0 2011 Spectroscopic study of the competitive interaction between streptomycin and Evans blue to bovine serum albumin. Evans Blue 76-86 albumin Homo sapiens 97-110 21607702-10 2012 Exposure of wild-type (WT) and VASP ( -/- ) animals to normobaric hypoxia for 4 h resulted in an increase in Evans blue tissue extravasation that was significantly increased in VASP ( -/- ) animals compared to WT controls. Evans Blue 184-194 vasodilator stimulated phosphoprotein Homo sapiens 31-35 21607702-10 2012 Exposure of wild-type (WT) and VASP ( -/- ) animals to normobaric hypoxia for 4 h resulted in an increase in Evans blue tissue extravasation that was significantly increased in VASP ( -/- ) animals compared to WT controls. Evans Blue 184-194 vasodilator stimulated phosphoprotein Homo sapiens 252-256 22145952-5 2012 administration of a macromolecular Evans blue-albumin complex, resulted in dose-dependent extravasation of Evans blue-albumin at the HO-1 injection site. Evans Blue 35-45 heme oxygenase 1 Mus musculus 133-137 22145952-9 2012 In addition, induction of HO-1 in tumors by the water-soluble macromolecular HO-1 inducer pegylated hemin significantly increased tumor blood flow and Evans blue-albumin accumulation in tumors. Evans Blue 151-161 heme oxygenase 1 Mus musculus 26-30 22145952-9 2012 In addition, induction of HO-1 in tumors by the water-soluble macromolecular HO-1 inducer pegylated hemin significantly increased tumor blood flow and Evans blue-albumin accumulation in tumors. Evans Blue 151-161 heme oxygenase 1 Mus musculus 77-81 22257498-10 2012 RESULTS: Intratracheal instillation of LPS induced significant neutrophil infiltration into the lung interstitium and alveolar space, which was attenuated by pre-treatment with TAT-Pyk2-CT. TAT-Pyk2-CT pretreatment also attenuated 1) myeloperoxidase content in lung tissues, 2) vascular leakage as measured by Evans blue dye extravasation in the lungs and the increase in protein concentration in bronchoalveolar lavage, and 3) the decrease in lung compliance. Evans Blue 310-324 PTK2 protein tyrosine kinase 2 beta Mus musculus 181-185 22257498-10 2012 RESULTS: Intratracheal instillation of LPS induced significant neutrophil infiltration into the lung interstitium and alveolar space, which was attenuated by pre-treatment with TAT-Pyk2-CT. TAT-Pyk2-CT pretreatment also attenuated 1) myeloperoxidase content in lung tissues, 2) vascular leakage as measured by Evans blue dye extravasation in the lungs and the increase in protein concentration in bronchoalveolar lavage, and 3) the decrease in lung compliance. Evans Blue 310-324 PTK2 protein tyrosine kinase 2 beta Mus musculus 194-198 22114075-8 2012 A single dose of docetaxel in the n-3 PUFA group markedly reduced interstitial fluid pressure from 2 h after injection up to W(+1) when Evans blue extravasation was increased by 3-fold. Evans Blue 136-146 pumilio RNA binding family member 3 Homo sapiens 38-42 22801078-10 2012 Evan blue (EB) and Sodium fluorescein (NaFI) content of ACR group were significantly higher than those of control group (P < 0.05). Evans Blue 0-9 acrosin Rattus norvegicus 56-59 22801078-10 2012 Evan blue (EB) and Sodium fluorescein (NaFI) content of ACR group were significantly higher than those of control group (P < 0.05). Evans Blue 11-13 acrosin Rattus norvegicus 56-59 21772310-7 2011 Overexpression of VEGF reduced tight junction protein expression and increased Evans blue extravasation. Evans Blue 79-89 vascular endothelial growth factor A Mus musculus 18-22 21772310-8 2011 Compared with VEGF expression alone, coexpression of ANG1 with VEGF resulted in upregulation of tight junction protein expression and reduction of Evans blue leakage (AAV-ANG1/AAV-VEGF: 1.4 +- 0.3 versus AAV-VEGF: 2.8 +- 0.7, P=0.001). Evans Blue 147-157 angiopoietin 1 Mus musculus 53-57 21772310-8 2011 Compared with VEGF expression alone, coexpression of ANG1 with VEGF resulted in upregulation of tight junction protein expression and reduction of Evans blue leakage (AAV-ANG1/AAV-VEGF: 1.4 +- 0.3 versus AAV-VEGF: 2.8 +- 0.7, P=0.001). Evans Blue 147-157 vascular endothelial growth factor A Mus musculus 63-67 21772310-8 2011 Compared with VEGF expression alone, coexpression of ANG1 with VEGF resulted in upregulation of tight junction protein expression and reduction of Evans blue leakage (AAV-ANG1/AAV-VEGF: 1.4 +- 0.3 versus AAV-VEGF: 2.8 +- 0.7, P=0.001). Evans Blue 147-157 vascular endothelial growth factor A Mus musculus 63-67 21937264-1 2011 The mechanism of the competitive interaction of streptomycin and Evans blue (EB) to bovine serum albumin (BSA) has been studied by using both fluorimetry and spectrophtometry. Evans Blue 65-75 albumin Homo sapiens 91-104 21937264-1 2011 The mechanism of the competitive interaction of streptomycin and Evans blue (EB) to bovine serum albumin (BSA) has been studied by using both fluorimetry and spectrophtometry. Evans Blue 77-79 albumin Homo sapiens 91-104 21795695-6 2011 Pressure-overloaded calpain 4-deficient hearts took up a membrane-impermeant dye, Evans blue, indicating plasma membrane disruption. Evans Blue 82-92 calpain, small subunit 1 Mus musculus 20-29 21437287-5 2011 Mice intravenously administered with purified InhA or nanoparticles-conjugated to InhA demonstrated a time-dependent Evans Blue dye extravasation, leptomeningeal thickening, leukocyte infiltration, and brain parenchymal distribution of InhA indicating BBB leakage and cerebral hemorrhage. Evans Blue 117-131 inhibin alpha Mus musculus 46-50 22146586-10 2011 In gp91phox knockout mice, the changes in Evans blue extravasation, MMP-9 and occludin were at much smaller magnitudes when compared to the wild type. Evans Blue 42-52 cytochrome b-245, beta polypeptide Mus musculus 3-11 21437287-5 2011 Mice intravenously administered with purified InhA or nanoparticles-conjugated to InhA demonstrated a time-dependent Evans Blue dye extravasation, leptomeningeal thickening, leukocyte infiltration, and brain parenchymal distribution of InhA indicating BBB leakage and cerebral hemorrhage. Evans Blue 117-131 inhibin alpha Mus musculus 82-86 21437287-5 2011 Mice intravenously administered with purified InhA or nanoparticles-conjugated to InhA demonstrated a time-dependent Evans Blue dye extravasation, leptomeningeal thickening, leukocyte infiltration, and brain parenchymal distribution of InhA indicating BBB leakage and cerebral hemorrhage. Evans Blue 117-131 inhibin alpha Mus musculus 82-86 20877384-8 2011 Stroke-induced increases in cortical MMP-9 mRNA, enzyme activity and protein expression, TIMP-1 mRNA, and Evans blue extravasation were reduced by TPO intervention. Evans Blue 106-116 thrombopoietin like 1 Rattus norvegicus 147-150 21186375-8 2011 The inhibitory effect of E1 and E2 on Evans blue content was reduced by treatment with E1+P1 and E2+P2, respectively. Evans Blue 38-48 carboxylesterase 1C Rattus norvegicus 25-33 21278483-3 2011 Extravasation of Evans blue and immunoglobulin G (IgG) was observed in the hippocampal CA1-2 areas within 8 h after TFI, and peaked at 48 h. This extravasation was accompanied by loss of tight junction proteins, occludin, and zonula occludens-1, and degeneration of endothelial cells in the CA1-2 areas. Evans Blue 17-27 carbonic anhydrase 1 Rattus norvegicus 87-90 21278483-3 2011 Extravasation of Evans blue and immunoglobulin G (IgG) was observed in the hippocampal CA1-2 areas within 8 h after TFI, and peaked at 48 h. This extravasation was accompanied by loss of tight junction proteins, occludin, and zonula occludens-1, and degeneration of endothelial cells in the CA1-2 areas. Evans Blue 17-27 occludin Rattus norvegicus 212-220 21278483-3 2011 Extravasation of Evans blue and immunoglobulin G (IgG) was observed in the hippocampal CA1-2 areas within 8 h after TFI, and peaked at 48 h. This extravasation was accompanied by loss of tight junction proteins, occludin, and zonula occludens-1, and degeneration of endothelial cells in the CA1-2 areas. Evans Blue 17-27 carbonic anhydrase 1 Rattus norvegicus 87-92 20692381-4 2011 Our results showed that 30min after IL-1beta injection (2-6 mug kg-1), SP levels and Evans blue extravasation in bronchoalveolar lavage fluid were markedly increased and these responses were eliminated or largely reduced in neonatal capsaicin-treated rats. Evans Blue 85-95 interleukin 1 beta Rattus norvegicus 36-44 21092735-3 2011 VEGF alone significantly increased the extravasation of Evans blue and up-regulated the levels of AQP4 protein expression in the injured spinal cord issue, but the levels of AQP1 expression were not significantly changed. Evans Blue 56-66 vascular endothelial growth factor A Homo sapiens 0-4 21269989-8 2011 The vascular permeability of the pancreatic microcirculation significantly increased after the onset of SAP, and injection of recombinant rat VEGF significantly increased the leakage rate of Evans Blue. Evans Blue 191-201 vascular endothelial growth factor A Rattus norvegicus 142-146 20878232-2 2011 Leakage of Evans blue and sodium fluorescein indicated increased BBB permeability only immediately (15 min), but not 1.5 and 24 h following probe implantation. Evans Blue 11-21 ALMS1, centrosome and basal body associated Mus musculus 65-68 20870012-7 2010 Furthermore, evaluation of BBB permeability by Evans Blue extravasation showed that Ang II significantly affected the BBB, inducing 3.8 times (P<0.05, compared to vehicle) higher permeability. Evans Blue 47-57 angiogenin, ribonuclease, RNase A family, 5 Mus musculus 84-87 20437588-4 2010 RESULTS: Thrombin reduced brain microvascular endothelial cell (BMVEC) and perivascular astrocyte immunoreactivity-indicating either cell injury or death-and functionally disrupted the BBB as measured by increased water content and extravasation of sodium fluorescein and Evans blue dyes 24 hours later. Evans Blue 272-282 coagulation factor II Rattus norvegicus 9-17 20483026-13 2010 MMP-9 knockdown mice also displayed less uptake of Evans blue and reduced brain water content compared with control siRNA-treated group. Evans Blue 51-61 matrix metallopeptidase 9 Mus musculus 0-5 20613638-3 2010 Intravenous Evans blue, given before stereotaxic gp120 injection into the caudate putamen of rats, was rapidly extravasated. Evans Blue 12-22 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 49-54 20470231-11 2010 High diffusion rates of fluorescein isothiocyanate-insulin and Evans blue were observed at the administered skin site and correlated well with the high absorption rate of insulin into the systemic circulation. Evans Blue 63-73 insulin Canis lupus familiaris 171-178 20219678-6 2010 EB leaked near the site of gp120 administration. Evans Blue 0-2 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 27-32 20167853-7 2010 In addition, SP-A(-/-) mice had increased lung edema as assessed by the increased levels of intravenously injected Evans blue dye leaking into the lungs. Evans Blue 115-129 surfactant associated protein A1 Mus musculus 13-17 19880804-5 2010 The extent of ischemia-reperfusion induced injury was similar in wild-type, TNFR1, and TNFR2 deficient mice; however, mice lacking TNFR1/TNFR2 had a significant approximately 40% lower left ventricular developed pressure, a approximately 65% greater creatine kinase release, and approximately 40% greater Evans blue dye uptake compared with littermates. Evans Blue 305-319 tumor necrosis factor receptor superfamily, member 1a Mus musculus 131-136 19858095-5 2010 HUVEC permeability, measured using Evans blue dye transfer, was significantly reduced in the presence of APC, and, in concordance, the tight junction associated protein zona occludens (ZO)-1 was up-regulated and localized peripherally around cells, compared with controls. Evans Blue 35-45 APC regulator of WNT signaling pathway Homo sapiens 105-108 20176991-3 2010 METHODS AND RESULTS: Unexpectedly, reendothelialization (assessed by resistance to Evans blue staining) and circulating EPC counts (EPC culture assay) were greater in ApoE(-/-) mice than in WT mice, and transplantation of ApoE(-/-) bone marrow in WT mice accelerated endothelial recovery and increased recruitment of bone marrow-derived EPCs to the neoendothelium. Evans Blue 83-93 apolipoprotein E Mus musculus 167-171 20186304-13 2010 The Evans blue dye result was lower for the CLP+O(3) group vs. the CLP+O(2) group and the cecal ligation/puncture group but similar to that of the SHAM group. Evans Blue 4-14 coactosin-like F-actin binding protein 1 Rattus norvegicus 44-47 20186304-13 2010 The Evans blue dye result was lower for the CLP+O(3) group vs. the CLP+O(2) group and the cecal ligation/puncture group but similar to that of the SHAM group. Evans Blue 4-14 coactosin-like F-actin binding protein 1 Rattus norvegicus 67-70 19074514-12 2009 In vivo, intradermal injection of CRP-induced vascular exudation of Evans blue dye in SHR-SP rats, in which expression of LOX-1 is greatly enhanced. Evans Blue 68-82 C-reactive protein Rattus norvegicus 34-37 19525473-9 2009 The results from CD31 immunostaining and Evans blue permeability assay suggest that the low vessel density, poor vascular permeability, and binding site barrier are likely responsible for the overall low tumor uptake of the highly EGFR-expressing SQB20 tumors. Evans Blue 41-51 epidermal growth factor receptor Homo sapiens 231-235 19166937-3 2009 Results showed that treatment with HIF-1alpha siRNA reduced the infarct volume, decreased mortality, improved neurological deficits and reduced Evans blue extravasation. Evans Blue 144-154 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 35-45 20150748-6 2010 Pretreatment with a neurokinin-1 receptor antagonist (FK888) significantly reduced ovalbumin-induced extravasation of Evans blue dye. Evans Blue 118-132 substance-P receptor Cavia porcellus 20-41 19794399-5 2010 Microinfusion of Evans blue albumin and amyloid-beta(1-40) (Abeta) caused perivascular labeling in the inferior colliculus, labeled the surrounding meninges, and Abeta-labeled-specific blood vessels in the caudate and olfactory bulb and was deposited in cervical lymph nodes. Evans Blue 17-27 amyloid beta precursor protein Rattus norvegicus 60-65 19794399-5 2010 Microinfusion of Evans blue albumin and amyloid-beta(1-40) (Abeta) caused perivascular labeling in the inferior colliculus, labeled the surrounding meninges, and Abeta-labeled-specific blood vessels in the caudate and olfactory bulb and was deposited in cervical lymph nodes. Evans Blue 17-27 amyloid beta precursor protein Rattus norvegicus 162-167 19646426-7 2009 MMP-9 null mice receiving wild-type bone marrow showed enhanced Evans blue extravasation as early as 1 h post-reperfusion compared to wild-type mice replaced with MMP-9 null bone marrow. Evans Blue 64-74 matrix metallopeptidase 9 Mus musculus 0-5 19530183-4 2009 In the Tm3 mice, Evans blue dye uptake in muscle and serum levels of creatine kinase were markedly increased following downhill exercise, and the force drop following a series of lengthening contractions in isolated muscles (extensor digitorum longus) was also significantly increased in these mice. Evans Blue 17-31 tropomyosin 1, alpha Mus musculus 7-10 19571314-8 2009 Moreover, endogenous APC prevents cancer cell-induced vascular leakage as assessed by the Evans Blue Dye assay, and SEW2871 treatment reversed MPC1609-dependent vascular leakage. Evans Blue 90-104 APC, WNT signaling pathway regulator Mus musculus 21-24 19291676-8 2009 Ad2/HIF-1 alpha/VP16 but not Ad2/VEGF reduced tissue Evans blue dye content. Evans Blue 53-67 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 4-15 19074514-12 2009 In vivo, intradermal injection of CRP-induced vascular exudation of Evans blue dye in SHR-SP rats, in which expression of LOX-1 is greatly enhanced. Evans Blue 68-82 oxidized low density lipoprotein receptor 1 Rattus norvegicus 122-127 18992318-7 2009 At 15 months of age, SAMP8 and SAMR1 mice showed higher Evans blue extravasation in CA1 and Fissure than ICR-CD1 mice. Evans Blue 56-66 carbonic anhydrase 1 Mus musculus 84-87 18725212-0 2008 VEGF increases blood-brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice. Evans Blue 51-61 vascular endothelial growth factor A Homo sapiens 0-4 18718505-7 2008 Results showed an increase in the brain water content and the presence of Evans blue in the brain tissue of thermally injured rats, temporally associated with an increased expression of endogenous tPA and uPA. Evans Blue 74-84 plasminogen activator, urokinase Rattus norvegicus 205-208 18352832-7 2008 Evans blue extravasation increased in both the Wt and Tg rats, but was less in the SOD1 Tg rats. Evans Blue 0-10 superoxide dismutase 1 Rattus norvegicus 83-87 19035264-4 2008 RESULTS: TNF-alpha increased permeability of strial capillary endothelial cells notably, and permeation rate to Evans blue heightened significantly (P < 0.01) and increased under higher concentrations of TNF-alpha as well as lengthened the durations. Evans Blue 112-122 tumor necrosis factor Cavia porcellus 207-216 19035264-5 2008 Being as a NO donator, L-Arg significantly enhanced the ability of TNF-alpha which increasing permeability of strial capillary endothelial cells; permeation rate to Evans blue heightened significantly (P < 0.01), which obviously rose up when the concentration of Evans blue added. Evans Blue 165-175 tumor necrosis factor Cavia porcellus 67-76 19035264-5 2008 Being as a NO donator, L-Arg significantly enhanced the ability of TNF-alpha which increasing permeability of strial capillary endothelial cells; permeation rate to Evans blue heightened significantly (P < 0.01), which obviously rose up when the concentration of Evans blue added. Evans Blue 266-276 tumor necrosis factor Cavia porcellus 67-76 18452188-10 2008 Consistent with these findings, in vivo application of S100A8/A9 in mice was in itself sufficient to induce pancreatic cell-cell contract dissociation as indicated by Evans Blue extravasation. Evans Blue 167-177 S100 calcium binding protein A8 (calgranulin A) Mus musculus 55-61 17921328-3 2007 Adenosine A(3) receptor-selective agonist 2-chloro-N(6)-(3-iodobenzyl)adenosine-5"-N-methyluronamide (Cl-IBMECA; 0.07 mg/kg ip) reduced skeletal muscle injury with a significant decrease in both Evans blue dye staining (5.4 +/- 2.6%, n = 8 mice vs. vehicle-treated 28 +/- 6%, n = 7 mice, P < 0.05) and serum creatine kinase level (1,840 +/- 910 U/l, n = 13 vs. vehicle-treated 12,600 +/- 3,300 U/l, n = 14, P < 0.05), an effect that was selectively blocked by an A(3) receptor antagonist 3-ethyl-5-benzyl-2-methyl-6-phenyl-4-phenylethynyl-1,4-(+/-)-dihydropyridine-3,5-dicarboxylate (MRS-1191; 0.05 mg/kg). Evans Blue 195-209 adenosine A3 receptor Mus musculus 0-23 19066083-8 2008 Infusion of thrombin + tPA markedly increased Evans blue tissue content in ipsilateral brain samples (p < 0.05). Evans Blue 46-56 coagulation factor II Rattus norvegicus 12-20 19066083-8 2008 Infusion of thrombin + tPA markedly increased Evans blue tissue content in ipsilateral brain samples (p < 0.05). Evans Blue 46-56 plasminogen activator, tissue type Rattus norvegicus 23-26 17363608-4 2007 Indeed, Lewis lung carcinoma cells implanted into Cav-1 KO mice had increased tumor vascular permeability, measured by Evans blue extravasation and fibrinogen deposition compared with tumors implanted into wild-type (WT) mice. Evans Blue 119-129 caveolin 1, caveolae protein Mus musculus 50-55 16835630-4 2007 Administration of Fn14-Fc decoy resulted in faster recovery of motor function and a 66.4%+/-10% decrease in Evans blue dye extravasation when treatment was administered immediately after MCAO and a 46.1%+/-13.1% decrease when animals were treated 1 h later (n=4, P<0.05). Evans Blue 108-122 tumor necrosis factor receptor superfamily, member 12a Mus musculus 18-22 16835630-5 2007 Genetic deficiency of Fn14 resulted in a 60%+/-12.8% decrease in the volume of the ischemic lesion (n=6, P<0.05), and a 87%+/-22% inhibition in Evans blue dye extravasation 48 h after the onset of the ischemic insult (n=6, P<0.005). Evans Blue 147-161 tumor necrosis factor receptor superfamily, member 12a Mus musculus 22-26 17190866-11 2007 Evans blue dye-positive myocytes with disruption of dystrophin were present in 2AxMCM mice treated with tamoxifen. Evans Blue 0-14 dystrophin, muscular dystrophy Mus musculus 52-62 17645933-7 2007 This is evidenced from the fact that rats subjected to 4h of heat stress (38 degrees C) showed a significant increase in the translocation of Evans blue and (131)Iodine from plasma to cisternal CSF, and manifested blue staining of the dorsal surface of the hippocampus and caudate nucleus. Evans Blue 142-152 colony stimulating factor 2 Rattus norvegicus 194-197 16054019-4 2005 Dystrophin localization detected by immunostaining age-dependently to the myoplasm and the in situ sarcolemma fragility evaluated by Evans blue entry was increased in the same cardiomyocytes. Evans Blue 133-143 dystrophin Rattus norvegicus 0-10 16716015-9 2006 The amount of extravasated Evans blue in rat ligated hindlimb muscle (7 days after treatment) treated with both AngI and VEGF was significantly less compared with that in the rats transfected with VEGF alone (P < 0.01). Evans Blue 27-37 vascular endothelial growth factor A Rattus norvegicus 121-125 16636607-8 2006 The maximum release of MMP-9 preceded the development of pulmonary complications, verified by histology and extravasation of Evans blue. Evans Blue 125-135 matrix metallopeptidase 9 Rattus norvegicus 23-28 15937288-9 2005 Finally, Evans blue albumin accumulation in lungs of WT mice was significant (50 vs. 15% increase in iNOS(-/-) mice compared with control animals) in response to MV and was prevented by treatment of the animals with the iNOS inhibitor aminoguanidine. Evans Blue 9-19 nitric oxide synthase 2, inducible Mus musculus 101-105 15937288-9 2005 Finally, Evans blue albumin accumulation in lungs of WT mice was significant (50 vs. 15% increase in iNOS(-/-) mice compared with control animals) in response to MV and was prevented by treatment of the animals with the iNOS inhibitor aminoguanidine. Evans Blue 9-19 nitric oxide synthase 2, inducible Mus musculus 220-224 16874110-2 2006 Importantly, Evans blue-positive cardiomyocytes with leaky plasma membranes were also positive for cathepsin D, suggesting a link between autophagic degeneration and cell death. Evans Blue 13-23 cathepsin D Homo sapiens 99-110 16490762-12 2006 Specific AT(1) and ACE-blockade before acute non-resuscitated HS significantly increased EB extravasation in the rat ileum by 53 and 66%, respectively. Evans Blue 89-91 angiotensin I converting enzyme Rattus norvegicus 19-22 16671473-5 2006 Intracerebral administration of nNOS antiserum (1 : 20) 5 minutes and 1 hour after TBI significantly attenuated brain edema formation, Evans blue leakage, and nNOS expression in the injured cortex and the underlying subcortical regions. Evans Blue 135-145 nitric oxide synthase 1 Rattus norvegicus 32-36 20021022-2 2006 METHOD: Single-dose and repeat-dose toxicity of intravenous injection of LHRH-PE40 was studied by clinical signs, hematology, blood chemistry and histopathology, and lung permeability to Evans blue dye. Evans Blue 187-197 gonadotropin releasing hormone 1 Rattus norvegicus 73-77 15978251-10 2005 Evans Blue leakage from retinas treated with VEGF was 2.0 fold higher than that of contra-lateral untreated eyes (P<0.05) while leakage of eyes from endostatin treated animals was unchanged. Evans Blue 0-10 vascular endothelial growth factor A Mus musculus 45-49 15815585-7 2005 In addition, GET-1 brains exhibited more Evans blue extravasation and showed decreased endothelial occludin expression after MCAO, correlating with higher brain water content and increased cerebral edema. Evans Blue 41-51 grainyhead like transcription factor 3 Mus musculus 13-18 15695561-11 2005 SB-203580 increased accumulation of Evans blue dye in myocytes depleted of sarcolemmal dystrophin during reperfusion, whereas cotreatment with BDM facilitated restoration of sarcolemmal dystrophin and mitigated sarcolemmal damage after withdrawal of BDM. Evans Blue 36-46 dystrophin Rattus norvegicus 87-97 15820445-6 2005 HDC protected against IL-2-induced macroscopic pulmonary lesions, reduced edema (up to 62% reduction in lung wet/dry weight ratio) and reduced capillary leakage into the lungs as measured by a reduction in Evans Blue dye content. Evans Blue 206-220 interleukin 2 Mus musculus 22-26 15782105-7 2005 RESULTS: Intravenous injection of the TRPV-1 agonist capsaicin induced a dose-dependent increase in Evans blue accumulation in the rat pancreas (P < 0.05 vs. vehicle control). Evans Blue 100-110 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 38-44 15966693-7 2005 RESULTS: Extravasation of Evans Blue dye was found in all specimens injected with rVEGF, and was quantified using a spectrophotometer. Evans Blue 26-36 vascular endothelial growth factor A Rattus norvegicus 82-87 15763998-5 2005 The EB dye extravasation increased in cerebellum (p<.001) and diencephalon (p<.05) of L-NAME plus ANG II-treated animals. Evans Blue 4-6 angiotensinogen Rattus norvegicus 104-110 15763998-11 2005 This study indicates that, in L-NAME hypertensive rats, ANG II leads to an increase in the extravasation of EB dye to brain as a result of decreased activity of tight junction proteins and astrocytes, and LPS could significantly attenuate the EB dye transport to the brain through the increased activity of tight junction proteins and astrocytes. Evans Blue 108-110 angiotensinogen Rattus norvegicus 56-62 15763998-11 2005 This study indicates that, in L-NAME hypertensive rats, ANG II leads to an increase in the extravasation of EB dye to brain as a result of decreased activity of tight junction proteins and astrocytes, and LPS could significantly attenuate the EB dye transport to the brain through the increased activity of tight junction proteins and astrocytes. Evans Blue 108-114 angiotensinogen Rattus norvegicus 56-62 15166556-13 2004 At 1 h after CPB, the transvascular escape rate of Evans blue dye averaged 11.5 +/- 1.3%/h in patients with the 00BB C4 phenotype; this value was significantly higher (P < 0.01) than that in patients with other C4 phenotypes. Evans Blue 51-61 complement C4B (Chido blood group) Homo sapiens 117-119 15546742-0 2004 Evans Blue is an inhibitor of nuclear factor-kappa B (NF-kappaB)-DNA binding. Evans Blue 0-10 nuclear factor kappa B subunit 1 Homo sapiens 30-52 15546742-0 2004 Evans Blue is an inhibitor of nuclear factor-kappa B (NF-kappaB)-DNA binding. Evans Blue 0-10 nuclear factor kappa B subunit 1 Homo sapiens 54-63 15546742-4 2004 In this context, we report Evans Blue as a novel inhibitor of NF-kappaB-DNA binding. Evans Blue 27-37 nuclear factor kappa B subunit 1 Homo sapiens 62-71 15546742-5 2004 Evans Blue was found to be inhibiting DNA binding of NF-kappaB at a low concentration of 100 microM. Evans Blue 0-10 nuclear factor kappa B subunit 1 Homo sapiens 53-62 15693613-6 2004 The Evans blue dye extravasation in the main bronchial, but not tracheal, tissue of OA-challenged mice was significantly increased as compared with that of sensitized control animals. Evans Blue 4-18 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 84-86 15001448-6 2004 The loss of dystrophin preceded uptake of the membrane-impermeable Evans blue dye by myocytes that occurred after the withdrawal of BDM and was associated with creatine kinase release and the development of contracture. Evans Blue 67-81 dystrophin Rattus norvegicus 12-22 15020292-5 2004 S1P produced an approximately 40-50% reduction in LPS-mediated extravasation of Evans blue dye albumin, bronchoalveolar lavage protein content, and lung tissue myeloperoxidase activity (reflecting phagocyte infiltration). Evans Blue 80-94 sphingosine-1-phosphate receptor 1 Mus musculus 0-3 15020292-6 2004 Consistent with systemic barrier enhancement, S1P significantly decreased Evans blue dye albumin extravasation and myeloperoxidase content in renal tissues of LPS-treated mice. Evans Blue 74-88 sphingosine-1-phosphate receptor 1 Mus musculus 46-49 15166556-13 2004 At 1 h after CPB, the transvascular escape rate of Evans blue dye averaged 11.5 +/- 1.3%/h in patients with the 00BB C4 phenotype; this value was significantly higher (P < 0.01) than that in patients with other C4 phenotypes. Evans Blue 51-61 complement C4B (Chido blood group) Homo sapiens 214-216 15060315-6 2004 RESULTS: There was a clear spatial relation between MMP-9 expression and Evans blue extravasation. Evans Blue 73-83 matrix metallopeptidase 9 Mus musculus 52-57 15163690-7 2004 Dual whole-cell recordings revealed that retrograde signaling between fast-spiking interneurons and pyramidal cells was enhanced under conditions of maximal efficacy of VGLUT3-mediated glutamate uptake, whereas it was reduced when glutamate uptake was inhibited by incrementing concentrations of the nonselective VGLUT inhibitor Evans blue (0.5-5.0 microm) or intracellular Cl- concentrations (4-145 mm). Evans Blue 329-339 solute carrier family 17 member 8 Rattus norvegicus 169-175 14556973-1 2003 C1 inhibitor (C1INH) deficient mice have increased vascular permeability that can be demonstrated by the extravasation of Evans Blue dye. Evans Blue 122-132 serine (or cysteine) peptidase inhibitor, clade G, member 1 Mus musculus 0-12 15050628-2 2004 Of the 13 dyes tested, four exhibited IC(50) value of less than 10 microM, Evans Blue lowest IC(50) of 1.3 microM against PTP1B. Evans Blue 75-85 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 122-127 14556973-1 2003 C1 inhibitor (C1INH) deficient mice have increased vascular permeability that can be demonstrated by the extravasation of Evans Blue dye. Evans Blue 122-132 serine (or cysteine) peptidase inhibitor, clade G, member 1 Mus musculus 14-19 12391098-6 2003 Intratracheal TNF-alpha and ceramide treatment of rats significantly increased lung permeability, as was evidenced by extravasation of Evans blue dye into alveolar lavage and lung tissue. Evans Blue 135-149 tumor necrosis factor Rattus norvegicus 14-23 14507673-9 2003 Furthermore, we show that systemic treatment with the proteasomal inhibitor 1) reduces muscle membrane damage, as revealed by vital staining (with Evans blue dye) of the diaphragm and gastrocnemius muscle isolated from treated mdx mice, and 2) ameliorates the histopathological signs of muscular dystrophy, as judged by hematoxylin and eosin staining of muscle biopsies taken from treated mdx mice. Evans Blue 147-157 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 66-77 12890920-3 2003 Upon reperfusion, the membrane impermeable dye, Evans blue (EB), accumulated in cardiomyocytes depleted of dystrophin. Evans Blue 48-58 dystrophin Rattus norvegicus 107-117 12890920-3 2003 Upon reperfusion, the membrane impermeable dye, Evans blue (EB), accumulated in cardiomyocytes depleted of dystrophin. Evans Blue 60-62 dystrophin Rattus norvegicus 107-117 14753473-3 2003 Repeated topical application of BDNF or IGF-1 (0.1 1microg, 0.5 microg or 1 microg in 10 microl) onto the spinal cord 30 min before SCI or 2, 5, 10 or 30 min thereafter significantly attenuated BSCB permeability to Evans blue and iodine. Evans Blue 215-225 brain-derived neurotrophic factor Rattus norvegicus 32-36 14753473-3 2003 Repeated topical application of BDNF or IGF-1 (0.1 1microg, 0.5 microg or 1 microg in 10 microl) onto the spinal cord 30 min before SCI or 2, 5, 10 or 30 min thereafter significantly attenuated BSCB permeability to Evans blue and iodine. Evans Blue 215-225 insulin-like growth factor 1 Rattus norvegicus 40-45 14522921-13 2003 In the irradiated spinal cord of ASMase +/+ mice, there was evidence of albumin immunoreactivity and Evans blue dye staining around microvessels, and (99m)Tc-diethylenetriamine pentaacetic acid uptake increased at 24 h. Nonirradiated controls and the irradiated spinal cord of ASMase -/- mice demonstrated no evidence of leakage. Evans Blue 101-115 sphingomyelin phosphodiesterase 1, acid lysosomal Mus musculus 33-39 12781870-2 2003 In cultured bovine aortic endothelial cells (BAECs), tryptase, trypsin and PAR-2 activating peptide impaired the barrier function as determined by the permeability of protein-conjugated Evans blue. Evans Blue 186-196 F2R like trypsin receptor 1 Bos taurus 75-80 12548213-6 2003 Permeability to Evans blue dye was evaluated in arteries after incubation with vascular endothelial growth factor, vascular endothelial growth factor plus angiopoietin-1, or vehicle, and in arteries that were obtained from women with preeclampsia. Evans Blue 16-30 vascular endothelial growth factor A Homo sapiens 115-149 12548213-11 2003 Evans blue dye staining was higher after incubation with vascular endothelial growth factor but was reversed by the addition of angiopoietin-1. Evans Blue 0-14 vascular endothelial growth factor A Homo sapiens 57-91 12548213-11 2003 Evans blue dye staining was higher after incubation with vascular endothelial growth factor but was reversed by the addition of angiopoietin-1. Evans Blue 0-14 angiopoietin 1 Homo sapiens 128-142 12414501-4 2002 We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. Evans Blue 247-261 a disintegrin and metallopeptidase domain 12 (meltrin alpha) Mus musculus 20-26 11846625-7 2002 The increased EB dye transfer from blood to the brain in status epilepticus and acute hyperglycaemia plus status epilepticus was attenuated by the treatment with catalase and alpha -tocopherol. Evans Blue 14-16 catalase Rattus norvegicus 162-170 12198614-7 2002 After 24 h, tumor necrosis factor activity was higher in cerebrospinal fluid of TLR2(-/-) than wt mice (P<.05) and was related to increased blood-brain barrier permeability (Evans blue staining, P<.02). Evans Blue 177-187 toll-like receptor 2 Mus musculus 80-84 12084390-10 2002 Moreover, the content of Evans blue dye markedly increased in the cerebellum (p < 0.001) and slightly increased in diencephalon region (p < 0.05) in L-NAME plus ANG II. Evans Blue 25-39 angiotensinogen Rattus norvegicus 167-173 12084390-11 2002 Losartan reduced the increased BBB permeability to Evans blue dye in L-NAME (p < 0.01) and L-NAME plus ANG II (p < 0.001). Evans Blue 51-61 angiotensinogen Rattus norvegicus 106-112 12084390-12 2002 These results indicate that L-NAME and L-NAME plus ANG II both lead to an increase in microvascular Evans blue dye efflux to brain, and losartan treatment attenuates this protein-bound dye transport into brain tissue presumably due to its protective effect on endothelial cells of brain vessels. Evans Blue 100-114 angiotensinogen Rattus norvegicus 51-57 11896897-6 2002 To test whether a combination of IL-1beta (10 ng/mL) and TNFalpha (100 ng/mL) induced Evans blue extravasation, the trachea was exposed to an aerosol of these cytokines (n = 5). Evans Blue 86-96 tumor necrosis factor Cavia porcellus 57-65 11896897-9 2002 RESULTS: TNFalpha and IL-1beta aerosol challenge significantly increased Evans blue extravasation (28.9 +/- 1.6 microg/g wet tissue, mean +/- SE) compared to saline challenge (13.8 +/- 3.0 microg/g; P < 0.05). Evans Blue 73-83 tumor necrosis factor Cavia porcellus 9-17 11896897-9 2002 RESULTS: TNFalpha and IL-1beta aerosol challenge significantly increased Evans blue extravasation (28.9 +/- 1.6 microg/g wet tissue, mean +/- SE) compared to saline challenge (13.8 +/- 3.0 microg/g; P < 0.05). Evans Blue 73-83 interleukin-1 beta Cavia porcellus 22-30 11846625-8 2002 These data suggest that a partial reduction in the production of reactive oxygen species by catalase and alpha -tocopherol contributes to decreases in the content of EB dye across the BBB during pentylenetetrazole-induced status epilepticus in acute hyperglycaemic rats. Evans Blue 166-172 catalase Rattus norvegicus 92-100 12373543-0 2002 Repeated topical application of growth hormone attenuates blood-spinal cord barrier permeability and edema formation following spinal cord injury: an experimental study in the rat using Evans blue, ([125])I-sodium and lanthanum tracers. Evans Blue 186-196 gonadotropin releasing hormone receptor Rattus norvegicus 32-46 11134085-9 2000 In addition, Evans blue staining of muscle fibers reveals that the pathological process due to calpain 3 deficiency is associated with membrane alterations. Evans Blue 13-23 calpain 3 Mus musculus 95-104 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 insulin receptor substrate 2 Homo sapiens 177-182 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 growth factor receptor bound protein 2 Homo sapiens 267-271 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 cyclin dependent kinase 20 Homo sapiens 302-305 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 interferon induced protein 44 Homo sapiens 306-309 11359148-9 2001 Extravasation of Evans blue dye was found in all specimens injected by tumor necrosis factor-alpha, which was qualified using a fluorescence microscope and quantified using a spectrophotometer. Evans Blue 17-31 tumor necrosis factor Rattus norvegicus 71-98 11201815-6 2001 We injected PAF (1 microg/kg) intravenously, and the amount of PAF-induced microvascular leakage was measured with extravasation of Evans blue dye (30 mg/kg, injected intravenously 5 minutes before the injection of PAF) by means of spectrophotometry and fluorescence microscopy. Evans Blue 132-142 PCNA clamp associated factor Rattus norvegicus 63-66 11201815-6 2001 We injected PAF (1 microg/kg) intravenously, and the amount of PAF-induced microvascular leakage was measured with extravasation of Evans blue dye (30 mg/kg, injected intravenously 5 minutes before the injection of PAF) by means of spectrophotometry and fluorescence microscopy. Evans Blue 132-142 PCNA clamp associated factor Rattus norvegicus 63-66 11190267-7 2000 ANP inducing a dose-dependent increase in vascular permeability of rat skin was confirmed by the extravasation of the circulating Evans blue. Evans Blue 130-140 natriuretic peptide A Rattus norvegicus 0-3 11567062-8 2001 Correspondingly, blood-brain barrier disruption assessed via Evans Blue leakage was significantly attenuated in MMP-9 knock-out mice compared with wild types. Evans Blue 61-71 matrix metallopeptidase 9 Mus musculus 112-117 11416032-0 2001 Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue. Evans Blue 121-131 insulin like growth factor 1 Homo sapiens 18-46 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 insulin like growth factor 1 Homo sapiens 38-43 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 insulin like growth factor 1 receptor Homo sapiens 86-100 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 insulin like growth factor 1 receptor Homo sapiens 102-108 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 insulin receptor substrate 1 Homo sapiens 136-164 11416032-6 2001 We found that ATA and EB mimicked the IGF-I effect on tyrosine phosphorylation of the IGF-I receptor (IGF-IR) and its major substrates, insulin receptor substrate-1 (IRS-1) and IRS-2; induced the association of these substrates with phosphatidylinositol 3-kinase and Grb2; and activated Akt kinase and p42/p44 mitogen-activated protein kinases. Evans Blue 22-24 insulin receptor substrate 1 Homo sapiens 166-171 10589971-4 1999 Previous administration of the beta2-adrenoceptor agonist clenbuterol reduced Evans blue extravasation and water content, but did not change vesicle frequency. Evans Blue 78-88 adrenoceptor beta 2 Rattus norvegicus 31-49 10449196-8 1999 Molecular modeling analyses on Evans blue and trypan blue docked into the TNF-alpha molecule support these experimental results by demonstrating that these compounds share with suramin a similar binding mode to TNF-alpha. Evans Blue 31-41 tumor necrosis factor Homo sapiens 74-83 11148865-11 2000 Lung water content was not significantly influenced by AAG, whereas Evans blue extravasation was significantly diminished by all three doses of AAG. Evans Blue 68-78 orosomucoid 1 Rattus norvegicus 144-147 10449196-7 1999 Evans blue and trypan blue inhibited TNF-alpha/p55 binding with an IC50 of 0.75 and 1.00 mM, respectively (suramin IC50: 0.65 mM); no effect was observed with the other molecules. Evans Blue 0-10 tumor necrosis factor Homo sapiens 37-46 10449196-7 1999 Evans blue and trypan blue inhibited TNF-alpha/p55 binding with an IC50 of 0.75 and 1.00 mM, respectively (suramin IC50: 0.65 mM); no effect was observed with the other molecules. Evans Blue 0-10 TNF receptor superfamily member 1A Homo sapiens 47-50 9809804-6 1998 Pilocarpine enhanced the action of neurokinin A and, furthermore, substance P combined with either VIP, PACAP or CGRP resulted in accumulation of Evans blue. Evans Blue 146-156 vasoactive intestinal peptide Rattus norvegicus 99-102 10448052-5 1999 The extent of striatal AQP4 mRNA induction did not correlate with neuronal degeneration, but it did with extravasation of Evans blue dye as a marker of BBB disruption. Evans Blue 122-136 aquaporin 4 Homo sapiens 23-27 10410329-4 1999 Thus, 4 h after the injection of SEB the increase in paw weight in OVX-mice treated with OE2 (10 micrograms/kg in corn oil) was 15.0 +/- 0.9 mg, while the exudation corresponded to 2.1 +/- 0.3 micrograms of Evans blue dye/g of tissue. Evans Blue 207-217 early B cell factor 3 Mus musculus 89-92 9920798-4 1999 Further application of EB in the presence of suramin, a blocker of P2-purinergic receptor, or AOPCP, an inhibitor of 5"-nucleotidase, still increased IK. Evans Blue 23-25 5'-nucleotidase ecto Homo sapiens 117-132 10077247-10 1999 ), a selective inhibitor of neutral endopeptidase (NEP), increased baseline leakage of Evans blue in the absence of any exogenous inflammatory mediator. Evans Blue 87-97 membrane metallo endopeptidase Mus musculus 28-49 10077247-10 1999 ), a selective inhibitor of neutral endopeptidase (NEP), increased baseline leakage of Evans blue in the absence of any exogenous inflammatory mediator. Evans Blue 87-97 membrane metallo endopeptidase Mus musculus 51-54 9809804-6 1998 Pilocarpine enhanced the action of neurokinin A and, furthermore, substance P combined with either VIP, PACAP or CGRP resulted in accumulation of Evans blue. Evans Blue 146-156 adenylate cyclase activating polypeptide 1 Rattus norvegicus 104-109 9809804-6 1998 Pilocarpine enhanced the action of neurokinin A and, furthermore, substance P combined with either VIP, PACAP or CGRP resulted in accumulation of Evans blue. Evans Blue 146-156 calcitonin-related polypeptide alpha Rattus norvegicus 113-117 9732288-9 1998 Vital staining with Evans blue dye revealed that muscle lacking gamma-sarcoglycan developed membrane disruptions like those seen in dystrophin-deficient muscle. Evans Blue 20-34 sarcoglycan, gamma (dystrophin-associated glycoprotein) Mus musculus 64-81 10375800-2 1998 METHODS: In rats, Evans blue (2.5%, 1 mL.L-1) was injected i.v. Evans Blue 18-28 ribosomal protein L4 Rattus norvegicus 41-44 9753274-0 1998 Recombinant or plasma-derived antisecretory factor inhibits cholera toxin-induced increase in Evans blue permeation of rat intestinal capillaries. Evans Blue 94-104 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 Rattus norvegicus 30-50 9421440-5 1998 The effect of CRH on Evans blue extravasation was stronger than equimolar concentrations of the mast cell secretagogue compound 48/80 or SP. Evans Blue 21-31 corticotropin releasing hormone Rattus norvegicus 14-17 9701350-6 1998 Brain edema was significantly reduced in VEGF-treated animals (P = 0.01), and furthermore, extravasation of Evans blue was also decreased in those animals (P < 0.01). Evans Blue 108-118 vascular endothelial growth factor A Rattus norvegicus 41-45 9701350-8 1998 These results indicate that treatment with topical VEGF application significantly reduces ischemic brain damage, such as infarct volume, edema formation, and extravasation of Evans blue, and that the reductions were associated with that of neuronal injury. Evans Blue 175-185 vascular endothelial growth factor A Rattus norvegicus 51-55 9421440-11 1998 The effect of CRH on Evans blue extravasation and mast cell degranulation was inhibited by the mast cell stabilizer disodium cromoglycate (cromolyn), but not by the antisecretory molecule somatostatin. Evans Blue 21-31 corticotropin releasing hormone Rattus norvegicus 14-17 9334342-7 1997 We also studied Evans blue dispersion in transgenic mice bearing different dystrophin mutations, and we demonstrated that cytoskeletal and sarcolemmal attachment of dystrophin might be a necessary requirement to prevent serious fiber damage. Evans Blue 16-26 dystrophin, muscular dystrophy Mus musculus 165-175 11939061-3 1998 The results showed that SAH produced a significant decrease in rCBF in caudate nucleus and blood-brain barrier damage which displayed increased extravasation of Evans blue to brain tissue. Evans Blue 161-171 CCAAT/enhancer binding protein zeta Rattus norvegicus 63-67 9166854-3 1997 Here, we report that intradermal injection of RANTES 10 ng/50 microL subcutaneously in the abdominal skin produced a strong inflammatory reaction, as evidenced by Evans blue dye, greater than FMLP (10(-6) mol/L) (approximately 57%); while MCP-1, 10 ng/50 microL was less effective than FMLP (10(-6) mol/L) (approximately 54%). Evans Blue 163-173 C-C motif chemokine ligand 5 Rattus norvegicus 46-52 8967991-3 1996 In addition to diminishing GluR6-mediated peak current amplitude, EB significantly altered receptor desensitization by slowing the rate of onset by approximately 2-fold (1 microM EB), slowing the rate of recovery by approximately 2-fold (0.1 microM EB), and increasing the steady state to peak current amplitude ratio by approximately 50-fold (1 microM EB). Evans Blue 66-68 glutamate ionotropic receptor kainate type subunit 2 Homo sapiens 27-32 9176264-4 1997 PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin. Evans Blue 278-288 tumor necrosis factor Homo sapiens 25-34 9176264-4 1997 PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin. Evans Blue 278-288 tumor necrosis factor Homo sapiens 79-88 8852584-6 1996 By measuring the concentration of Evans blue dye extravasation into the joint perfusate following its intravenous injection, bradykinin-induced plasma extravasation in the knee joint cavity was determined spectrophotometrically. Evans Blue 34-44 kininogen 1 Homo sapiens 125-135 8799559-25 1996 Both ET-1 and, to a lesser extent, IRL 1620 (0.1-2 nmol kg-1) evoked albumin accumulation in cardiac tissues in a dose-dependent fashion as measured by the local extravascular accumulation of Evans blue dye in conscious rats. Evans Blue 192-206 endothelin 1 Rattus norvegicus 5-9 8648086-7 1996 For IFA, 37 degrees C was the ideal incubation temperature tested, whereas the optimal incubation temperature tested for ISH was 47 degrees C. Of the blocking agents compared, Evans blue dye prevented background fluorescence to a greater extent than either calf serum or bovine serum albumin. Evans Blue 176-190 albumin Gallus gallus 278-291 8893728-3 1996 Evans blue dye leakage 4 hours after injury was attenuated in a CuZn-SOD dose-dependent manner with decreases of 18.6%, 40.9%, and 48.8%, in the Tg1.5x, Tg3.1x, and Tg5x groups, respectively. Evans Blue 0-10 superoxide dismutase 1, soluble Mus musculus 64-72 8831182-4 1996 Evan"s blue conjugated bovine serum albumin was used as a marker of vasopermeability and added into the upper chamber solution. Evans Blue 0-11 albumin Bos taurus 30-43 8857635-10 1996 In separate experiments, intravesical NGF at concentrations greater than 1 microgram/ml was found to elicit a dose-dependent extravasation of Evan"s blue into the bladder. Evans Blue 142-153 nerve growth factor Rattus norvegicus 38-41 8712398-11 1996 We found that beta-endorphin has a clear, dose-related, antiinflammatory effect, reducing the tissue extravasation of Evans blue and its absorbency, especially with large doses. Evans Blue 118-128 proopiomelanocortin Homo sapiens 14-28 7576695-5 1995 PAF also elicited 95 to 307% increases in lung permeability as measured by Evans blue extravasation. Evans Blue 75-85 patchy fur Mus musculus 0-3 8992493-8 1996 Treatment with aldose reductase inhibitors selectively normalized EB extravasation in the kidney. Evans Blue 66-68 aldo-keto reductase family 1 member B1 Rattus norvegicus 15-31 8826088-10 1995 Evans blue dye-labeled bovine serum albumin could not be detected on the abluminal side without disruption of the HUVEC monolayer. Evans Blue 0-10 albumin Homo sapiens 36-43 7589224-7 1995 The area with increased binding of [125I]endothelin-1 corresponded to the zone of arterial injury stained with Evans blue. Evans Blue 111-121 endothelin-1 Oryctolagus cuniculus 41-53 8749313-9 1995 Vital staining with Evans blue is useful not only for distinguishing degenerating muscle fibers, but also for studying the degeneration process biochemically in dystrophin-deficient muscle. Evans Blue 20-30 dystrophin, muscular dystrophy Mus musculus 161-171 8528554-13 1995 ET-1 (1 nmol kg-1) enhanced albumin extravasation by 119 and 93% in the left ventricle and right atrium, respectively, as measured by the local extravascular accumulation of Evans blue dye. Evans Blue 174-188 endothelin 1 Rattus norvegicus 0-4 7768283-2 1995 Thrombin caused a concentration-dependent increase in Evans blue-albumin clearance across endothelial monolayers. Evans Blue 54-64 coagulation factor II, thrombin Bos taurus 0-8 7582486-11 1995 Endothelin-1 (ET-1) induced an accumulation of albumin-bound Evans blue dye in orthogradely perfused lungs. Evans Blue 61-71 endothelin 1 Rattus norvegicus 0-12 7582486-11 1995 Endothelin-1 (ET-1) induced an accumulation of albumin-bound Evans blue dye in orthogradely perfused lungs. Evans Blue 61-71 endothelin 1 Rattus norvegicus 14-18 9345463-5 1995 IGF-I treatment reduced permeability of the blood-spinal cord barrier to Evans blue-albumin. Evans Blue 73-83 insulin-like growth factor 1 Rattus norvegicus 0-5 7768283-3 1995 Isoprenaline inhibited thrombin-induced Evans blue-albumin clearance in a concentration-dependent manner (EC50 21 nM). Evans Blue 40-50 coagulation factor II, thrombin Bos taurus 23-31 21043709-8 1995 In addition, aurintricarboxylic acid, Evans blue and fucoidan all inhibited binding of vWF to both heparin and sulfatides with similar ICso values. Evans Blue 38-48 von Willebrand factor Homo sapiens 87-90 8566934-1 1995 The effect of the antagonist of platelet-activating factor (PAF), BN 50730, on PAF-and antigen- induced increase in microvascular leakage, using Evans blue dye as an index of permeability, was investigated in rat pulmonary tissues. Evans Blue 145-159 PCNA clamp associated factor Rattus norvegicus 60-63 8566934-2 1995 PAF (1 microgram/kg, iv) induced a marked increase in Evans blue dye content in trachea, main bronchi and small bronchi, that was significantly reduced upon pretreatment of the rats with BN 50730 (25 mg/kg, orally) and by the serotonin antagonist, methysergide (1 mg/kg, iv), only in the small bronchi. Evans Blue 54-68 PCNA clamp associated factor Rattus norvegicus 0-3 7858876-20 1994 ET-1 (1 nmol kg-1) enhanced albumin extravasation in the upper and lower bronchi, spleen, kidney,stomach and duodenum (up to 246%) as measured by the extravasation of Evans blue dye. Evans Blue 167-181 endothelin 1 Rattus norvegicus 0-4 7930605-9 1994 Inhibition of Th1-induced swelling was accompanied by a similar inhibition of vascular permeability, as measured by leakage of Evans blue. Evans Blue 127-137 negative elongation factor complex member C/D, Th1l Mus musculus 14-17 8298570-2 1993 The distribution of this compound in liver of rats treated with CCl4 (25-100 microL/100 g body weight) was more than five times higher than that of non-treated rats, corresponding to the accumulation of Evans Blue, a marker dye for capillary permeability. Evans Blue 203-213 C-C motif chemokine ligand 4 Rattus norvegicus 64-68 8032597-4 1994 Intravenous injection of PAF (1.0 and 5.0 micrograms kg-1) increased dose-dependently (up to 7.5 fold) the vascular permeability of the trachea, upper and lower bronchi to Evans blue dye (EB), a marker of albumin extravasation. Evans Blue 188-190 PCNA clamp associated factor Rattus norvegicus 25-28 8034214-1 1994 In order to check the entrance site of serum albumin into the aqueous humor, rabbits were injected intravenously either with Evans blue (which reacts very quickly with albumin) or horseradish peroxidase. Evans Blue 125-135 albumin Oryctolagus cuniculus 39-52 8132319-7 1994 Treatment with an anti-CD11a MAb also prevented mortality, Evans blue diffusion, and PMN and monocyte sequestration. Evans Blue 59-69 integrin alpha L Mus musculus 23-28 8309711-7 1993 Evans Blue extravasation was apparent in the deep paraspinal tissues surrounding the C1-3 vertebrae after mustard oil injection, and histological examination showed that mustard oil injection induced an inflammatory reaction in the rectus capitis posterior muscle. Evans Blue 0-10 complement C2 Rattus norvegicus 85-89 8358577-7 1993 Endothelin-1 (1 nmol kg-1) enhanced the vascular permeability of the upper and lower bronchi, kidney, stomach, duodenum and spleen (up to 270%) as measured by the extravasation of Evans blue dye. Evans Blue 180-190 endothelin 1 Rattus norvegicus 0-12 8391310-4 1993 HUVEC monolayer permeability to Evans blue dye-labeled albumin increased from 0.125 +/- 0.06 microL/min in control experiments to 0.380 +/- 0.09 microL/min after treatment with 100 nmol/L thrombin (P < .05). Evans Blue 32-42 coagulation factor II, thrombin Homo sapiens 188-196 7678460-5 1993 We found that Evans blue, a biphenyl derivative of naphthalene disulfonic acid, blocks at low concentrations (IC50 = 355 nM for the subunit combination GluR1,2) KA-mediated responses of the subunits GluR1, GluR1,2, GluR1,3, and GluR2,3 expressed in Xenopus oocytes but not responses of GluR3 or GluR6. Evans Blue 14-24 glutamate receptor, ionotropic, AMPA 1 L homeolog Xenopus laevis 152-157 7678460-5 1993 We found that Evans blue, a biphenyl derivative of naphthalene disulfonic acid, blocks at low concentrations (IC50 = 355 nM for the subunit combination GluR1,2) KA-mediated responses of the subunits GluR1, GluR1,2, GluR1,3, and GluR2,3 expressed in Xenopus oocytes but not responses of GluR3 or GluR6. Evans Blue 14-24 glutamate receptor, ionotropic, AMPA 1 L homeolog Xenopus laevis 199-204 7678460-5 1993 We found that Evans blue, a biphenyl derivative of naphthalene disulfonic acid, blocks at low concentrations (IC50 = 355 nM for the subunit combination GluR1,2) KA-mediated responses of the subunits GluR1, GluR1,2, GluR1,3, and GluR2,3 expressed in Xenopus oocytes but not responses of GluR3 or GluR6. Evans Blue 14-24 glutamate receptor, ionotropic, AMPA 1 L homeolog Xenopus laevis 199-204 7678460-5 1993 We found that Evans blue, a biphenyl derivative of naphthalene disulfonic acid, blocks at low concentrations (IC50 = 355 nM for the subunit combination GluR1,2) KA-mediated responses of the subunits GluR1, GluR1,2, GluR1,3, and GluR2,3 expressed in Xenopus oocytes but not responses of GluR3 or GluR6. Evans Blue 14-24 glutamate receptor, ionotropic, AMPA 1 L homeolog Xenopus laevis 199-204 7678460-5 1993 We found that Evans blue, a biphenyl derivative of naphthalene disulfonic acid, blocks at low concentrations (IC50 = 355 nM for the subunit combination GluR1,2) KA-mediated responses of the subunits GluR1, GluR1,2, GluR1,3, and GluR2,3 expressed in Xenopus oocytes but not responses of GluR3 or GluR6. Evans Blue 14-24 glutamate receptor, ionotropic, AMPA 2 S homeolog Xenopus laevis 228-233 1329914-1 1992 In this study we have shown, for the first time, that Japanese encephalitis virus (JEV) and a low molecular weight (10 kDa) macrophage-derived neutrophil chemotactic factor (MDF) produced following JEV infection in mice could cause an alteration in the permeability of the blood-brain barrier resulting in leakage of plasma protein bound Evans blue dye and radiolabelled erythrocytes in brain. Evans Blue 338-352 gametogenetin binding protein 1 Mus musculus 174-177 7678460-5 1993 We found that Evans blue, a biphenyl derivative of naphthalene disulfonic acid, blocks at low concentrations (IC50 = 355 nM for the subunit combination GluR1,2) KA-mediated responses of the subunits GluR1, GluR1,2, GluR1,3, and GluR2,3 expressed in Xenopus oocytes but not responses of GluR3 or GluR6. Evans Blue 14-24 glutamate receptor, ionotropic, AMPA 3 L homeolog Xenopus laevis 286-291 7678460-5 1993 We found that Evans blue, a biphenyl derivative of naphthalene disulfonic acid, blocks at low concentrations (IC50 = 355 nM for the subunit combination GluR1,2) KA-mediated responses of the subunits GluR1, GluR1,2, GluR1,3, and GluR2,3 expressed in Xenopus oocytes but not responses of GluR3 or GluR6. Evans Blue 14-24 glutamate receptor, ionotropic, kainate 2 S homeolog Xenopus laevis 295-300 1467845-2 1992 Changes in vascular permeability following intravenous injections of human big-endothelin-1 (big-ET-1) and endothelin-1 (ET-1) were measured by extravasation of Evans blue dye (EB, 20 mg kg-1) in selected tissues. Evans Blue 161-175 endothelin 1 Homo sapiens 121-125 1559129-6 1992 PAF consistently increased the amount of Evans blue extravasation in the larynx, trachea, main bronchi and intrapulmonary airways in sham-operated rats. Evans Blue 41-51 PCNA clamp associated factor Rattus norvegicus 0-3 1504742-9 1992 Intrathoracic injection of PAF (1.9 nmol/cavity) induced pleurisy characterized by an increase in pleural exudate volume, and in accumulation of Evans Blue which was maximal at 30 min and lasted up to 4 h. When injected together with PAF, ET-1 (0.5 pmol/cavity) virtually abolished PAF-induced pleurisy. Evans Blue 145-155 patchy fur Mus musculus 27-30 1516634-6 1992 Evans blue dye extravasation, a marker of vascular permeability, increased up to 235% over control levels in specific vascular beds including the upper and lower bronchi, stomach, duodenum and kidney of ET-1 (1.0 nmol/kg)-treated animals. Evans Blue 0-14 endothelin 1 Rattus norvegicus 203-207 1739134-6 1992 GLUT1 expression was not dependent on restricted permeability as all tumors were highly permeable to Evans blue. Evans Blue 101-111 solute carrier family 2 member 1 Rattus norvegicus 0-5 1913150-4 1991 The two methods used for detection of a leaky barrier were immunocytochemical localization of extravasated serum albumin and circulating Evans blue that binds to serum albumin. Evans Blue 137-147 albumin Rattus norvegicus 162-175 1595396-4 1992 The interstitial bradykinin infusion caused focal blood-brain-barrier (BBB) opening to Evans Blue dye and was chemotaxic for granulocytes. Evans Blue 87-97 kininogen 1 Homo sapiens 17-27 1667286-7 1991 Endothelin-1 (0.1 and 1 nmol kg-1) increased dose-dependently the vascular permeability of the trachea, upper and lower bronchi, stomach, duodenum, spleen and kidney (up to 240%) as measured by the extravasation of Evans blue dye. Evans Blue 215-225 endothelin 1 Rattus norvegicus 0-12 1933287-5 1991 Binding of gp120 to these cells is inhibited by the dyes Aurintricarboxylic acid (ATA) and Evans blue (EB), which are known to inhibit specific gp120 and HIV-1 binding, and block HIV-1 infection, in CD4-expressing cells. Evans Blue 91-101 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 11-16 1933287-5 1991 Binding of gp120 to these cells is inhibited by the dyes Aurintricarboxylic acid (ATA) and Evans blue (EB), which are known to inhibit specific gp120 and HIV-1 binding, and block HIV-1 infection, in CD4-expressing cells. Evans Blue 91-101 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 144-149 1933287-5 1991 Binding of gp120 to these cells is inhibited by the dyes Aurintricarboxylic acid (ATA) and Evans blue (EB), which are known to inhibit specific gp120 and HIV-1 binding, and block HIV-1 infection, in CD4-expressing cells. Evans Blue 91-101 CD4 molecule Homo sapiens 199-202 1933287-5 1991 Binding of gp120 to these cells is inhibited by the dyes Aurintricarboxylic acid (ATA) and Evans blue (EB), which are known to inhibit specific gp120 and HIV-1 binding, and block HIV-1 infection, in CD4-expressing cells. Evans Blue 103-105 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 11-16 1933287-5 1991 Binding of gp120 to these cells is inhibited by the dyes Aurintricarboxylic acid (ATA) and Evans blue (EB), which are known to inhibit specific gp120 and HIV-1 binding, and block HIV-1 infection, in CD4-expressing cells. Evans Blue 103-105 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 144-149 1933287-5 1991 Binding of gp120 to these cells is inhibited by the dyes Aurintricarboxylic acid (ATA) and Evans blue (EB), which are known to inhibit specific gp120 and HIV-1 binding, and block HIV-1 infection, in CD4-expressing cells. Evans Blue 103-105 CD4 molecule Homo sapiens 199-202 2001074-1 1991 We studied the effect of dexamethasone on microvascular leakage (using Evans blue dye as a marker of plasma exudation) induced in rat airways by platelet-activating factor (PAF). Evans Blue 71-81 PCNA clamp associated factor Rattus norvegicus 145-171 2001074-1 1991 We studied the effect of dexamethasone on microvascular leakage (using Evans blue dye as a marker of plasma exudation) induced in rat airways by platelet-activating factor (PAF). Evans Blue 71-81 PCNA clamp associated factor Rattus norvegicus 173-176 1718343-2 1991 Suramin, Evans blue, and Trypan blue were shown to inhibit syncytia formation normally observed when HIV-1-infected cells are cocultured with CD4+ cells. Evans Blue 9-19 CD4 molecule Homo sapiens 142-145 1718343-7 1991 Evans blue showed partial blocking of gp120 binding to CD4 in a solid-phase enzyme-linked immunosorbent assay (ELISA). Evans Blue 0-10 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 38-43 1718343-7 1991 Evans blue showed partial blocking of gp120 binding to CD4 in a solid-phase enzyme-linked immunosorbent assay (ELISA). Evans Blue 0-10 CD4 molecule Homo sapiens 55-58 1713391-10 1991 Intravenous injections of Evans blue, which binds to plasma proteins, confirmed that albumin was taken up into damaged neurons almost immediately after the injury and showed that this uptake continued for at least 20 h. It is concluded that uptake of plasma proteins into damaged neurons may serve as early (and late) markers of neuronal injury. Evans Blue 26-36 albumin Rattus norvegicus 85-92 34449342-6 2022 In addition, the STB2@GO membrane exhibited a favorable capability for dye rejection,98.52% for Evans blue (EB), 99.26% for Victoria blue B (VB), 91.94% for Alizarin yellow (AY), and 93.21% for Neutral red (NR). Evans Blue 96-106 VANGL planar cell polarity protein 1 Homo sapiens 17-21 2085713-2 1990 Platelet activating factor (PAF; 1.0 and 5.0 micrograms kg-1) injected in the tail vein of unanaesthetized rats dose-dependently increased the vascular permeability of the trachea, upper and lower bronchi (up to 400%) as measured by the extravasation of Evans blue dye. Evans Blue 254-268 PAF1 homolog, Paf1/RNA polymerase II complex component Rattus norvegicus 28-34 2224865-8 1990 The observed tumor enhancement corresponded strongly with Evans blue staining; the TNF-treated tumors stained deep blue, while untreated tumors and normal tissues observed did not stain. Evans Blue 58-68 tumor necrosis factor Homo sapiens 83-86 2310053-1 1990 The blood-brain barrier to endogenous serum albumin labeled with Evans blue was studied by standard fluorescence microscopic techniques in cats. Evans Blue 65-75 albumin Felis catus 44-51 1693912-2 1990 Injection of substance P (2.5 X 10(-8) M) induced significant plasma extravasation in the skin (53 +/- 4 mm2 of Evans blue extravasation; mean +/- 1 SEM). Evans Blue 112-122 tachykinin precursor 1 Homo sapiens 13-24 33815104-9 2021 Further, 8-Br-ADPR attenuated the effects of METH and HIV-Tat on the BBB in tree shrews-namely, down-regulated TJ protein expression and increased BBB permeability to Evans blue (EB) and NaF. Evans Blue 167-177 tyrosine aminotransferase Homo sapiens 58-61 1979910-2 1990 We found that Evans blue and aurin tricarboxylic acid could completely inhibit binding of anti-CD4 (Leu3a) and rgp120 and have selectivity for the CD4 receptor. Evans Blue 14-24 CD4 molecule Homo sapiens 95-98 1979910-2 1990 We found that Evans blue and aurin tricarboxylic acid could completely inhibit binding of anti-CD4 (Leu3a) and rgp120 and have selectivity for the CD4 receptor. Evans Blue 14-24 CD4 molecule Homo sapiens 147-159 2105843-4 1990 In each tumor preparation, the injection of drug was paired with that of vascular reference substance, Evans" blue-labeled bovine serum albumin, and disposition parameters of the drug were corrected with those of vascular reference substance. Evans Blue 103-114 albumin Rattus norvegicus 130-143 2118717-9 1990 When a SAP of 180 mm Hg systolic was maintained for 6 min, a diffuse Evans blue staining was seen in 70% of the nimodipine animals (break-through of BBB). Evans Blue 69-79 amyloid P component, serum Rattus norvegicus 7-10 33973708-10 2021 Based on these data we conclude that addition of TB or EB during thrombin mediated fibrin polymerization slows the initial gelation time permitting generation of larger more uniform fibrin hydrogels with high-mechanical strength. Evans Blue 55-57 coagulation factor II, thrombin Homo sapiens 65-73 34875308-18 2022 Finally, administration of a single dose of rHDL-apoE3 in apoE KO mice markedly improved vascular permeability as demonstrated by the reduced concentration of Evans Blue dye in tissues such as the stomach, the tongue and the urinary bladder and ameliorated hypercholesterolemia. Evans Blue 159-169 apolipoprotein E Homo sapiens 49-54 34875308-18 2022 Finally, administration of a single dose of rHDL-apoE3 in apoE KO mice markedly improved vascular permeability as demonstrated by the reduced concentration of Evans Blue dye in tissues such as the stomach, the tongue and the urinary bladder and ameliorated hypercholesterolemia. Evans Blue 159-169 apolipoprotein E Mus musculus 58-62 34449342-6 2022 In addition, the STB2@GO membrane exhibited a favorable capability for dye rejection,98.52% for Evans blue (EB), 99.26% for Victoria blue B (VB), 91.94% for Alizarin yellow (AY), and 93.21% for Neutral red (NR). Evans Blue 108-110 VANGL planar cell polarity protein 1 Homo sapiens 17-21 34514847-6 2021 The therapeutic efficacy of autotaxin/LPA receptor blockade was evaluated using triphenyl tetrazolium chloride staining, Evans blue permeability, infrared imaging, mass spectrometry, and XF24 analyzer to evaluate blood-brain barrier integrity, autotaxin activity, and mitochondrial bioenergetics. Evans Blue 121-131 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 28-37 34699316-11 2021 Evans blue permeation assay demonstrated the potency of C3G in attenuating vascular leakage. Evans Blue 0-10 Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus 56-59 34590152-10 2021 AKR1C1 overexpression significantly attenuated lung injury, as shown by the changes in Evans blue leakage in the lung, lung wet/dry weight ratio, PaO2/FIO2 ratio, survival rate of mice and histological lung changes. Evans Blue 87-97 aldo-keto reductase family 1, member C6 Mus musculus 0-6 34115555-5 2021 Upregulation of miR-126 in CLP rats could improve brain injury and BBB marker protein level, reduce brain water content, Evans blue extravasation, inflammation, and excessive oxidative stress. Evans Blue 121-131 microRNA 126b Rattus norvegicus 16-23 34389390-4 2021 For EB dye biodegradation, the reason why the biodegradation efficiency (94.9%) of La-HNF was higher than that (86.8%) of La-HNP could be synergistic effect of immobilized laccase within 3D hierarchical structure of La-HNF. Evans Blue 4-6 kallikrein related peptidase 8 Homo sapiens 125-128 34227616-0 2021 Evans blue dye as an indicator of albumin permeability across a brain endothelial cell monolayer in vitro. Evans Blue 0-10 albumin Bos taurus 34-41 34557667-9 2021 Furthermore, IRG1-/- stroke animals presented aggravated blood-brain barrier disruption, associated with augmented Evans blue leakage and increased immune cell infiltrates in the ischaemic brain. Evans Blue 115-125 aconitate decarboxylase 1 Homo sapiens 13-17 34227616-2 2021 Therefore, Evans blue dye (EBD), an albumin-binding fluorescent tracer that is simple to detect and quantify, has been widely utilized for studying BEnd permeability during BBB disruption. Evans Blue 11-21 albumin Bos taurus 36-43 34719652-7 2021 Repeated intracerebroventricular administration of the specific TRPV4 antagonists HC-067047 and RN-1734 dose-dependently reduced brain water content and alleviated EB extravasation in FPI mice. Evans Blue 164-166 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 64-69 35619945-9 2022 Restoring miR-296-5p or depleting HDAC3 reduced Evans blue leakage in DR mice, attenuated apoptosis of retinal ganglion cells, reduced VEGF and MDA, and enhanced SOD activity in serum and retinal tissues of DR mice. Evans Blue 48-58 microRNA 296 Mus musculus 10-17 35048960-4 2022 VEGF-A inhibition also reduced the overall eNOS protein concentrations, increased occludin levels, and decreased the penetration of circulating Evans Blue dye across the BBB into the brain parenchyma, suggesting increased BBB integrity. Evans Blue 144-154 vascular endothelial growth factor A Mus musculus 0-6 35609523-5 2022 The effects of TRIM44 knockdown on inflammation, neurological function, and TLR4-NF-kappaB signaling in TBI rats were revealed by the detection of proinflammatory cytokines and TLR4-NF-kappaB signaling molecules, modified neurological severity score, brain water content, and Evans blue permeability. Evans Blue 276-286 tripartite motif-containing 44 Rattus norvegicus 15-21 35609523-5 2022 The effects of TRIM44 knockdown on inflammation, neurological function, and TLR4-NF-kappaB signaling in TBI rats were revealed by the detection of proinflammatory cytokines and TLR4-NF-kappaB signaling molecules, modified neurological severity score, brain water content, and Evans blue permeability. Evans Blue 276-286 toll-like receptor 4 Rattus norvegicus 177-181 35619945-9 2022 Restoring miR-296-5p or depleting HDAC3 reduced Evans blue leakage in DR mice, attenuated apoptosis of retinal ganglion cells, reduced VEGF and MDA, and enhanced SOD activity in serum and retinal tissues of DR mice. Evans Blue 48-58 histone deacetylase 3 Mus musculus 34-39 35083148-13 2021 High-power confocal microscopy revealed that, in the tumor, the surrounding of AQP4 by Evans Blue was decreased. Evans Blue 87-97 aquaporin 4 Rattus norvegicus 79-83 35278430-5 2022 Additionally, specific knockout of endothelial JMJD3 delayed EC regeneration, enhanced endothelial mesenchymal transition, impaired endothelial barrier function as determined by increased Evans blue staining and inflammatory cell infiltration, and accelerated neointima formation in the AVF created by venous end to arterial side anastomosis in CKD mice. Evans Blue 188-198 KDM1 lysine (K)-specific demethylase 6B Mus musculus 47-52 35450406-7 2022 The HSP90 protein expressions were raised after TBI at the pericontusional area, especially at 3 d. Our study suggested that 17-DA-treated mice improved the recovery ability of neurological deficits and decreased brain edema, Evans blue extravasation, and the loss of tight junction proteins (TJPs) post-TBI. Evans Blue 226-236 heat shock protein, 3 Mus musculus 4-9 35628852-7 2022 We observed that the BBB permeability was significantly increased in Cntnap2-/- rats compared to littermate wild-type (WT) animals as determined by FITC-dextran and Evans blue assay. Evans Blue 165-175 contactin associated protein 2 Rattus norvegicus 69-76 35182949-8 2022 The Evans Blue leakage and brain water content were obviously reduced (P < 0.05) in vasoactive intestinal peptide-treated rats compared with those of control rats at 72 and 96 h after stroke. Evans Blue 4-14 vasoactive intestinal peptide Rattus norvegicus 84-113 35456579-1 2022 Serum albumin binding moieties (ABMs) such as the Evans blue (EB) dye fragment and the 4-(p-iodophenyl)butyryl (IP) have been used to improve the pharmacokinetic profile of many radiopharmaceuticals. Evans Blue 50-60 albumin Homo sapiens 6-13 35456579-1 2022 Serum albumin binding moieties (ABMs) such as the Evans blue (EB) dye fragment and the 4-(p-iodophenyl)butyryl (IP) have been used to improve the pharmacokinetic profile of many radiopharmaceuticals. Evans Blue 62-64 albumin Homo sapiens 6-13 35451766-4 2022 VEGF promotes vascular leak of serum proteins in the dermis, enabling Evans Blue-labeled albumin extravasation from the circulation and subsequent accumulation in the skin. Evans Blue 70-80 vascular endothelial growth factor A Mus musculus 0-4 34987657-0 2022 Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics. Evans Blue 0-10 fibroblast activation protein Mus musculus 33-62 34987657-3 2022 In this study, we aimed to develop a series of albumin binder-truncated Evans blue (EB) modified FAP targeted radiotracers, and optimize the pharmacokinetic (PK) characteristics to overcome the existing limitations in order to apply in the radionuclide therapy of cancer. Evans Blue 72-82 fibroblast activation protein Mus musculus 97-100