PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24945434-5	2014	Treatment with STAT3 inhibitors, Stattic and Niclosamide, enhanced motor neuron differentiation only in FGF2-primed hNSCs, as shown by increased homeobox gene Hb9 mRNA levels as well as HB9+ and microtubule-associated protein 2 (MAP2)+ co-labeled cells.	stattic	33-40	signal transducer and activator of transcription 3	Homo sapiens	15-20
24945434-5	2014	Treatment with STAT3 inhibitors, Stattic and Niclosamide, enhanced motor neuron differentiation only in FGF2-primed hNSCs, as shown by increased homeobox gene Hb9 mRNA levels as well as HB9+ and microtubule-associated protein 2 (MAP2)+ co-labeled cells.	stattic	33-40	fibroblast growth factor 2	Homo sapiens	104-108
24945434-5	2014	Treatment with STAT3 inhibitors, Stattic and Niclosamide, enhanced motor neuron differentiation only in FGF2-primed hNSCs, as shown by increased homeobox gene Hb9 mRNA levels as well as HB9+ and microtubule-associated protein 2 (MAP2)+ co-labeled cells.	stattic	33-40	motor neuron and pancreas homeobox 1	Homo sapiens	159-162
24945434-5	2014	Treatment with STAT3 inhibitors, Stattic and Niclosamide, enhanced motor neuron differentiation only in FGF2-primed hNSCs, as shown by increased homeobox gene Hb9 mRNA levels as well as HB9+ and microtubule-associated protein 2 (MAP2)+ co-labeled cells.	stattic	33-40	motor neuron and pancreas homeobox 1	Homo sapiens	186-189
24945434-5	2014	Treatment with STAT3 inhibitors, Stattic and Niclosamide, enhanced motor neuron differentiation only in FGF2-primed hNSCs, as shown by increased homeobox gene Hb9 mRNA levels as well as HB9+ and microtubule-associated protein 2 (MAP2)+ co-labeled cells.	stattic	33-40	microtubule associated protein 2	Homo sapiens	195-227
24945434-5	2014	Treatment with STAT3 inhibitors, Stattic and Niclosamide, enhanced motor neuron differentiation only in FGF2-primed hNSCs, as shown by increased homeobox gene Hb9 mRNA levels as well as HB9+ and microtubule-associated protein 2 (MAP2)+ co-labeled cells.	stattic	33-40	microtubule associated protein 2	Homo sapiens	229-233
20960209-6	2010	ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide).	stattic	234-270	signal transducer and activator of transcription 3	Mus musculus	107-112
20960209-6	2010	ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide).	stattic	234-270	signal transducer and activator of transcription 3	Rattus norvegicus	114-119
20960209-6	2010	ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide).	stattic	234-270	signal transducer and activator of transcription 3	Rattus norvegicus	114-119
34262291-15	2021	The STAT3 inhibitor 6-nitrobenzo(b)thiophene 1,1-dioxide (Stattic) also inhibited the enzymatic activity of GSR and induced the death of cervical cancer cells.	stattic	58-65	signal transducer and activator of transcription 3	Homo sapiens	4-9
33818016-15	2021	Furthermore, on treating ASCs with Stattic, an active STAT3 inhibitor, the cells were markedly sensitive to intrinsic pathway-mediated apoptosis.	stattic	35-42	signal transducer and activator of transcription 3	Homo sapiens	54-59
34693451-6	2021	Combined treatment with gefitinib and stattic, an inhibitor for STAT3 phosphorylation, engenders more evident inhibitory effects on cell proliferation, migration, and invasion and promotive effects on cell apoptosis and G1 phase arrest in OS, compared with the single exposure to gefitinib or stattic.	stattic	38-45	signal transducer and activator of transcription 3	Homo sapiens	64-69
34693451-9	2021	Additional administration of stattic in EGFR-targeted therapies may contribute to improve the efficacy for OS.	stattic	29-36	epidermal growth factor receptor	Homo sapiens	40-44
34675657-9	2021	Furthermore, the effect of C5a over-expression on RCC cells" proliferation, migration, and invasion could be blocked by Stattic, a STAT3-specific inhibitor.	stattic	120-127	hemolytic complement	Mus musculus	27-30
34675657-9	2021	Furthermore, the effect of C5a over-expression on RCC cells" proliferation, migration, and invasion could be blocked by Stattic, a STAT3-specific inhibitor.	stattic	120-127	signal transducer and activator of transcription 3	Homo sapiens	131-136
34407787-11	2021	Both dasatinib (Src inhibitor) and stattic (STAT3 inhibitor) inhibited cell proliferation and induced apoptosis in TamR cells.	stattic	35-42	signal transducer and activator of transcription 3	Homo sapiens	44-49
34246283-13	2021	Administration of Stattic, a STAT3 phosphorylation inhibitor, rescued the number of astrocyte-neuron interactions in 5XFAD mice.	stattic	18-25	signal transducer and activator of transcription 3	Mus musculus	29-34
34262291-15	2021	The STAT3 inhibitor 6-nitrobenzo(b)thiophene 1,1-dioxide (Stattic) also inhibited the enzymatic activity of GSR and induced the death of cervical cancer cells.	stattic	58-65	gutter shaped root	Mus musculus	108-111
34262291-19	2021	Conclusion: Stattic inhibits the enzymatic activity of GSR and induces STAT3-independent but ROS-dependent death of cervical cancer cells, suggesting its potential application as a therapeutic agent for human cervical cancers.	stattic	12-19	gutter shaped root	Mus musculus	55-58
34262291-19	2021	Conclusion: Stattic inhibits the enzymatic activity of GSR and induces STAT3-independent but ROS-dependent death of cervical cancer cells, suggesting its potential application as a therapeutic agent for human cervical cancers.	stattic	12-19	signal transducer and activator of transcription 3	Homo sapiens	71-76
35465350-7	2022	Stt and Tcz induce a decrease in STAT-3 phosphorylation in the DU145 cells and, in turn, induce an increase of NKp46 and a decrease of TIGIT expression in NK-92 cells.	stattic	0-3	signal transducer and activator of transcription 3	Homo sapiens	33-39
34206429-0	2021	Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing-Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice.	stattic	39-46	signal transducer and activator of transcription 3	Mus musculus	30-35
35465350-7	2022	Stt and Tcz induce a decrease in STAT-3 phosphorylation in the DU145 cells and, in turn, induce an increase of NKp46 and a decrease of TIGIT expression in NK-92 cells.	stattic	0-3	natural cytotoxicity triggering receptor 1	Homo sapiens	111-116
35465350-7	2022	Stt and Tcz induce a decrease in STAT-3 phosphorylation in the DU145 cells and, in turn, induce an increase of NKp46 and a decrease of TIGIT expression in NK-92 cells.	stattic	0-3	T cell immunoreceptor with Ig and ITIM domains	Homo sapiens	135-140
33600884-8	2022	And treatment with Stattic (an inhibitor of STAT3) restrained the effect of OGD plus hemin on NF-kappaB pathway activity, inflammation, cell viability and TEER.	stattic	19-26	signal transducer and activator of transcription 3	Rattus norvegicus	44-49
34016951-9	2021	To determine the behavioral relevance of STAT3 activation during alcohol withdrawal, we treated rats with the STAT3 inhibitor stattic and tested for sucrose preference as a measure of anhedonia.	stattic	126-133	signal transducer and activator of transcription 3	Rattus norvegicus	41-46
34016951-9	2021	To determine the behavioral relevance of STAT3 activation during alcohol withdrawal, we treated rats with the STAT3 inhibitor stattic and tested for sucrose preference as a measure of anhedonia.	stattic	126-133	signal transducer and activator of transcription 3	Rattus norvegicus	110-115
33641239-5	2021	Mice treated with the STAT3 inhibitor stattic drank less ethanol than vehicle-treated mice, demonstrating the behavioral importance of STAT3.	stattic	38-45	signal transducer and activator of transcription 3	Mus musculus	22-27
33641239-5	2021	Mice treated with the STAT3 inhibitor stattic drank less ethanol than vehicle-treated mice, demonstrating the behavioral importance of STAT3.	stattic	38-45	signal transducer and activator of transcription 3	Mus musculus	135-140
33628191-9	2021	Stattic, a selective STAT3 inhibitor, administration resulted in a complete attenuation in the production of IL-1beta and IL-6 in ocular hypertensive animals.	stattic	0-7	signal transducer and activator of transcription 3	Rattus norvegicus	21-26
33628191-9	2021	Stattic, a selective STAT3 inhibitor, administration resulted in a complete attenuation in the production of IL-1beta and IL-6 in ocular hypertensive animals.	stattic	0-7	interleukin 1 alpha	Rattus norvegicus	109-117
33628191-9	2021	Stattic, a selective STAT3 inhibitor, administration resulted in a complete attenuation in the production of IL-1beta and IL-6 in ocular hypertensive animals.	stattic	0-7	interleukin 6	Rattus norvegicus	122-126
31942696-0	2020	STAT3 inhibitory stattic enhances immunogenic cell death induced by chemotherapy in cancer cells.	stattic	17-24	signal transducer and activator of transcription 3	Mus musculus	0-5
33839684-2	2021	Strategies to inactivate STAT3 are being pursued as potential anticancer therapies and have led to the identification of Stattic (6-nitrobenzo[b]thiophene-1,1-dioxide) as a "specific" STAT3 inhibitor that is often used to interrogate STAT3-mediated gene expression in vitro and in vivo.	stattic	130-166	signal transducer and activator of transcription 3	Homo sapiens	25-30
33839684-2	2021	Strategies to inactivate STAT3 are being pursued as potential anticancer therapies and have led to the identification of Stattic (6-nitrobenzo[b]thiophene-1,1-dioxide) as a "specific" STAT3 inhibitor that is often used to interrogate STAT3-mediated gene expression in vitro and in vivo.	stattic	130-166	signal transducer and activator of transcription 3	Homo sapiens	184-189
33839684-2	2021	Strategies to inactivate STAT3 are being pursued as potential anticancer therapies and have led to the identification of Stattic (6-nitrobenzo[b]thiophene-1,1-dioxide) as a "specific" STAT3 inhibitor that is often used to interrogate STAT3-mediated gene expression in vitro and in vivo.	stattic	130-166	signal transducer and activator of transcription 3	Homo sapiens	184-189
33839684-5	2021	In PC3 cells, Stattic alone inhibited gene expression of CCL20 and CCL2, but activated expression of TNFA, CEBPD, SOX2, and MYC.	stattic	14-21	C-C motif chemokine ligand 20	Homo sapiens	57-62
33839684-5	2021	In PC3 cells, Stattic alone inhibited gene expression of CCL20 and CCL2, but activated expression of TNFA, CEBPD, SOX2, and MYC.	stattic	14-21	C-C motif chemokine ligand 2	Homo sapiens	57-61
33839684-5	2021	In PC3 cells, Stattic alone inhibited gene expression of CCL20 and CCL2, but activated expression of TNFA, CEBPD, SOX2, and MYC.	stattic	14-21	tumor necrosis factor	Homo sapiens	101-105
33839684-5	2021	In PC3 cells, Stattic alone inhibited gene expression of CCL20 and CCL2, but activated expression of TNFA, CEBPD, SOX2, and MYC.	stattic	14-21	CCAAT enhancer binding protein delta	Homo sapiens	107-112
33839684-5	2021	In PC3 cells, Stattic alone inhibited gene expression of CCL20 and CCL2, but activated expression of TNFA, CEBPD, SOX2, and MYC.	stattic	14-21	SRY-box transcription factor 2	Homo sapiens	114-118
33839684-5	2021	In PC3 cells, Stattic alone inhibited gene expression of CCL20 and CCL2, but activated expression of TNFA, CEBPD, SOX2, and MYC.	stattic	14-21	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	124-127
32991955-8	2020	This was confirmed by utilization of NFkB inhibitor, PDTC and STAT3 inhibitor, Stattic which caused reduction in inflammatory cytokines from DEHP-treated monocytes in ASD group.	stattic	79-86	signal transducer and activator of transcription 3	Homo sapiens	62-67
32962858-7	2020	Compared to monotherapy, combined treatment of glioma cells with PLK1 and STAT3 inhibitors, BI2536 and Stattic, respectively, showed lower expression of MYC, synergistic induction of cell invasion and apoptosis in vitro, and tumor inhibition in xenografts.	stattic	103-110	polo like kinase 1	Homo sapiens	65-69
32962858-7	2020	Compared to monotherapy, combined treatment of glioma cells with PLK1 and STAT3 inhibitors, BI2536 and Stattic, respectively, showed lower expression of MYC, synergistic induction of cell invasion and apoptosis in vitro, and tumor inhibition in xenografts.	stattic	103-110	signal transducer and activator of transcription 3	Homo sapiens	74-79
32962858-7	2020	Compared to monotherapy, combined treatment of glioma cells with PLK1 and STAT3 inhibitors, BI2536 and Stattic, respectively, showed lower expression of MYC, synergistic induction of cell invasion and apoptosis in vitro, and tumor inhibition in xenografts.	stattic	103-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	153-156
33096140-6	2020	Our results show that intraperitoneal injection of Stattic, a molecule that selectively inhibits the activation of STAT3, decreases LPS-induced microglial activation in the hippocampus.	stattic	51-58	signal transducer and activator of transcription 3	Mus musculus	115-120
33096140-8	2020	A significant reduction of BACE1 levels was observed in the hippocampus of mice treated with LPS and Stattic compared to those exposed to LPS alone.	stattic	101-108	beta-site APP cleaving enzyme 1	Mus musculus	27-32
33256738-14	2020	The pyroptosic effect by S. aureus infection was promoted by either rapamycin or Stattic, a specific inhibitor for mTORC1 or STAT3.	stattic	81-88	CREB regulated transcription coactivator 1	Mus musculus	115-121
33256738-14	2020	The pyroptosic effect by S. aureus infection was promoted by either rapamycin or Stattic, a specific inhibitor for mTORC1 or STAT3.	stattic	81-88	signal transducer and activator of transcription 3	Homo sapiens	125-130
32863208-6	2020	Ten compounds previously shown to inhibit STAT3 were here found to irreversibly inhibit cellular TrxR1 activity (Auranofin, Stattic, 5,15-DPP, Galiellalactone, LLL12, Napabucasin, BP1-102, STA-21, S3I-201 and Degrasyn (WP1130)).	stattic	124-131	signal transducer and activator of transcription 3	Homo sapiens	42-47
32863208-6	2020	Ten compounds previously shown to inhibit STAT3 were here found to irreversibly inhibit cellular TrxR1 activity (Auranofin, Stattic, 5,15-DPP, Galiellalactone, LLL12, Napabucasin, BP1-102, STA-21, S3I-201 and Degrasyn (WP1130)).	stattic	124-131	thioredoxin reductase 1	Homo sapiens	97-102
32829707-12	2020	Furthermore, the increased expression of MMP-9 induced by C6-ceramide was inhibited by AG490 and Stattic.	stattic	97-104	matrix metallopeptidase 9	Homo sapiens	41-46
32507685-5	2020	The administration of Stattic, an inhibitor of STAT3, rescued the activation of astrocytes in primary cultured astrocytes and in the hippocampus of 6-month-old 5XFAD mice as well as impairments in learning and memory.	stattic	22-29	signal transducer and activator of transcription 3	Mus musculus	47-52
32653978-2	2020	Here, we studied the effect of Stattic (STAT3 inhibitor) loaded in nanostructured lipid carriers (NLCs) on enhancing the efficacy, cytotoxicity, and induction of apoptosis of doxorubicin in B16F10 mouse melanoma cancer cell.	stattic	31-38	signal transducer and activator of transcription 3	Mus musculus	40-45
32790751-0	2020	Correction: Stat3 inhibitor stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma.	stattic	28-35	signal transducer and activator of transcription 3	Homo sapiens	12-17
31942696-8	2020	Interestingly, we found a higher level of ICD markers including CRT expression as well as HMGB1 and HSP70 secretion in the cells received combination therapy of stattic and DOX as compared with monotherapies.	stattic	161-168	high mobility group box 1	Mus musculus	90-95
31942696-8	2020	Interestingly, we found a higher level of ICD markers including CRT expression as well as HMGB1 and HSP70 secretion in the cells received combination therapy of stattic and DOX as compared with monotherapies.	stattic	161-168	heat shock protein 1B	Mus musculus	100-105
30953354-7	2019	The levels of fibrotic proteins in CFs stimulated with high concentrations of the recombinant FGF23 protein were reversed by N-acetylcysteine (NAC, a ROS inhibitor), ship information system 3 (a SMAD3 inhibitor), and Stattic (a STAT3 inhibitor).	stattic	217-224	fibroblast growth factor 23	Homo sapiens	94-99
32105676-5	2020	Exposure of CRC cells to LN521 enhanced STAT3 phosphorylation, and incubation with STAT3 inhibitors Napabucasin and Stattic was sufficient to block the LN521-driven self-renewal increase.	stattic	116-123	signal transducer and activator of transcription 3	Homo sapiens	83-88
31551033-3	2019	Stattic, a small molecular STAT3 inhibitor, can partially ameliorate lupus nephritis in mice.	stattic	0-7	signal transducer and activator of transcription 3	Mus musculus	27-32
30993753-1	2019	We investigated the role of stattic as an adjuvant molecule to increase the cytotoxicity of 5-fluorouracil (5-FU) through specific inhibition of molecular targets, signal transducer and activator of transcription 3 (STAT3) and nuclear factor erythroid 2-related factor 2 (Nrf2) in HT-29 colon cancer cells.	stattic	28-35	signal transducer and activator of transcription 3	Homo sapiens	164-214
30922625-6	2019	To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6.	stattic	98-105	signal transducer and activator of transcription 3	Homo sapiens	82-87
30922625-6	2019	To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6.	stattic	121-128	signal transducer and activator of transcription 3	Homo sapiens	27-32
30922625-6	2019	To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6.	stattic	121-128	signal transducer and activator of transcription 3	Homo sapiens	82-87
30922625-6	2019	To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6.	stattic	121-128	interleukin 6	Homo sapiens	220-224
28032735-0	2016	Combined Treatment with Stattic and Docetaxel Alters the Bax/Bcl-2 Gene Expression Ratio in Human Prostate Cancer Cells Docetaxel, recognized as a stabilizing microtubule agent, is frequently administrated as a first line treatment forprostate cancers.	stattic	24-31	BCL2 associated X, apoptosis regulator	Homo sapiens	57-60
28032735-0	2016	Combined Treatment with Stattic and Docetaxel Alters the Bax/Bcl-2 Gene Expression Ratio in Human Prostate Cancer Cells Docetaxel, recognized as a stabilizing microtubule agent, is frequently administrated as a first line treatment forprostate cancers.	stattic	24-31	BCL2 apoptosis regulator	Homo sapiens	61-66