PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18302342-1	2008	Mevalonate kinase (MK), which catalyzes a key reaction in polyisoprenoid and sterol metabolism in many organisms, is subject to feedback regulation by farnesyl diphosphate and related compounds.	farnesyl pyrophosphate	151-171	mevalonate kinase	Homo sapiens	0-17
18236008-1	2008	Squalene synthase (SQS) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to produce squalene (SQ), the first committed precursor for sterol, brassinosteroid, and triterpene biosynthesis.	farnesyl pyrophosphate	71-91	squalene synthase 1	Arabidopsis thaliana	0-17
18236008-1	2008	Squalene synthase (SQS) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to produce squalene (SQ), the first committed precursor for sterol, brassinosteroid, and triterpene biosynthesis.	farnesyl pyrophosphate	93-96	squalene synthase 1	Arabidopsis thaliana	0-17
18302342-1	2008	Mevalonate kinase (MK), which catalyzes a key reaction in polyisoprenoid and sterol metabolism in many organisms, is subject to feedback regulation by farnesyl diphosphate and related compounds.	farnesyl pyrophosphate	151-171	mevalonate kinase	Homo sapiens	19-21
18473904-1	2008	Synthesis of farnesyl pyrophosphate (FPP), a key intermediate of the isoprenoid biosynthesis pathway, is catalyzed by FPP synthase (FPPS).	farnesyl pyrophosphate	13-35	farnesyl diphosphate synthase	Homo sapiens	118-130
18473904-1	2008	Synthesis of farnesyl pyrophosphate (FPP), a key intermediate of the isoprenoid biosynthesis pathway, is catalyzed by FPP synthase (FPPS).	farnesyl pyrophosphate	13-35	farnesyl diphosphate synthase	Homo sapiens	132-136
18473904-1	2008	Synthesis of farnesyl pyrophosphate (FPP), a key intermediate of the isoprenoid biosynthesis pathway, is catalyzed by FPP synthase (FPPS).	farnesyl pyrophosphate	37-40	farnesyl diphosphate synthase	Homo sapiens	118-130
18473904-1	2008	Synthesis of farnesyl pyrophosphate (FPP), a key intermediate of the isoprenoid biosynthesis pathway, is catalyzed by FPP synthase (FPPS).	farnesyl pyrophosphate	37-40	farnesyl diphosphate synthase	Homo sapiens	132-136
18356691-4	2008	METHODS AND RESULTS: Simvastatin induced mRNA expression and protein secretion of VEGF in endothelial cells that were reversed by pretreatment with mevalonate and geranylgeranylpyrophosphate but not by farnesylpyrophosphate.	farnesyl pyrophosphate	202-223	vascular endothelial growth factor A	Homo sapiens	82-86
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	87-107	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	119-123
18310456-9	2008	Farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) reversed the simvastatin effects on TNF-alpha-induced activation of Ras/Rho/MAPK pathways.	farnesyl pyrophosphate	0-22	tumor necrosis factor	Mus musculus	105-114
18310456-9	2008	Farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) reversed the simvastatin effects on TNF-alpha-induced activation of Ras/Rho/MAPK pathways.	farnesyl pyrophosphate	24-27	tumor necrosis factor	Mus musculus	105-114
18310456-10	2008	FPP and GGPP also restored the simvastatin effects on TNF-alpha-induced suppression of Runx2 and ALP activity.	farnesyl pyrophosphate	0-3	tumor necrosis factor	Mus musculus	54-63
18310456-10	2008	FPP and GGPP also restored the simvastatin effects on TNF-alpha-induced suppression of Runx2 and ALP activity.	farnesyl pyrophosphate	0-3	runt related transcription factor 2	Mus musculus	87-92
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	87-107	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	226-230
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	87-107	sulfate adenylyltransferase	Saccharomyces cerevisiae S288C	261-265
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	109-112	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	119-123
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	109-112	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	226-230
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	109-112	sulfate adenylyltransferase	Saccharomyces cerevisiae S288C	261-265
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	168-171	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	119-123
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	168-171	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	226-230
17705244-4	2008	In order to enhance the availability of the precursor for synthesis of sesquiterpenes, farnesyl diphosphate (FPP), the ERG9 gene which is responsible for conversion of FPP to squalene was downregulated by replacing the native ERG9 promoter with the regulatable MET3 promoter combined with addition of 2 mM methionine to the medium.	farnesyl pyrophosphate	168-171	sulfate adenylyltransferase	Saccharomyces cerevisiae S288C	261-265
18296628-2	2008	We identified a maize terpene synthase, Terpene Synthase 23 (TPS23), that produces (E)-beta-caryophyllene from farnesyl diphosphate.	farnesyl pyrophosphate	111-131	(E)-beta-caryophyllene synthase	Zea mays	40-59
18296628-2	2008	We identified a maize terpene synthase, Terpene Synthase 23 (TPS23), that produces (E)-beta-caryophyllene from farnesyl diphosphate.	farnesyl pyrophosphate	111-131	(E)-beta-caryophyllene synthase	Zea mays	61-66
17942919-5	2007	The isoprenoids farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) significantly reverse atorvastatin-induced inhibition of Tsc2-/- cell growth, suggesting that atorvastatin dually targets a farnesylated protein, such as Rheb, and a geranylgeranylated protein, such as Rho, both of which have elevated activity in Tsc2-/- cells.	farnesyl pyrophosphate	16-37	TSC complex subunit 2	Mus musculus	140-144
17666588-1	2007	In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-beta (TRbeta) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might function as an agonist.	farnesyl pyrophosphate	136-158	T cell receptor beta locus	Homo sapiens	113-119
17666588-1	2007	In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-beta (TRbeta) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might function as an agonist.	farnesyl pyrophosphate	160-163	T cell receptor beta locus	Homo sapiens	113-119
17942919-5	2007	The isoprenoids farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) significantly reverse atorvastatin-induced inhibition of Tsc2-/- cell growth, suggesting that atorvastatin dually targets a farnesylated protein, such as Rheb, and a geranylgeranylated protein, such as Rho, both of which have elevated activity in Tsc2-/- cells.	farnesyl pyrophosphate	16-37	Ras homolog enriched in brain	Mus musculus	237-241
17942919-5	2007	The isoprenoids farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) significantly reverse atorvastatin-induced inhibition of Tsc2-/- cell growth, suggesting that atorvastatin dually targets a farnesylated protein, such as Rheb, and a geranylgeranylated protein, such as Rho, both of which have elevated activity in Tsc2-/- cells.	farnesyl pyrophosphate	16-37	TSC complex subunit 2	Mus musculus	330-334
17942919-5	2007	The isoprenoids farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) significantly reverse atorvastatin-induced inhibition of Tsc2-/- cell growth, suggesting that atorvastatin dually targets a farnesylated protein, such as Rheb, and a geranylgeranylated protein, such as Rho, both of which have elevated activity in Tsc2-/- cells.	farnesyl pyrophosphate	39-42	TSC complex subunit 2	Mus musculus	140-144
16972283-3	2006	The biogenesis of these JHs requires the synthesis of ethyl-substituted farnesyl diphosphate (FPP) by FPP synthase (FPPS).	farnesyl pyrophosphate	94-97	Farnesyl pyrophosphate synthase	Drosophila melanogaster	116-120
17176109-4	2006	We found that although H-Ras modified with FPP analogues p-NO2-AGPP, p-CN-AGPP, and Isox-GPP was an efficient substrate for C-terminal postprenylation processing by Rce1 and Icmt, co-injection of H-Ras with analogues p-NO2-AGPP, p-CN-AGPP, or Isox-GPP could not activate MAPK.	farnesyl pyrophosphate	43-46	Harvey rat sarcoma viral oncogene homolog L homeolog	Xenopus laevis	23-28
17176109-4	2006	We found that although H-Ras modified with FPP analogues p-NO2-AGPP, p-CN-AGPP, and Isox-GPP was an efficient substrate for C-terminal postprenylation processing by Rce1 and Icmt, co-injection of H-Ras with analogues p-NO2-AGPP, p-CN-AGPP, or Isox-GPP could not activate MAPK.	farnesyl pyrophosphate	43-46	Ras converting CAAX endopeptidase 1 S homeolog	Xenopus laevis	165-169
17176109-4	2006	We found that although H-Ras modified with FPP analogues p-NO2-AGPP, p-CN-AGPP, and Isox-GPP was an efficient substrate for C-terminal postprenylation processing by Rce1 and Icmt, co-injection of H-Ras with analogues p-NO2-AGPP, p-CN-AGPP, or Isox-GPP could not activate MAPK.	farnesyl pyrophosphate	43-46	isoprenylcysteine carboxyl methyltransferase S homeolog	Xenopus laevis	174-178
17176109-4	2006	We found that although H-Ras modified with FPP analogues p-NO2-AGPP, p-CN-AGPP, and Isox-GPP was an efficient substrate for C-terminal postprenylation processing by Rce1 and Icmt, co-injection of H-Ras with analogues p-NO2-AGPP, p-CN-AGPP, or Isox-GPP could not activate MAPK.	farnesyl pyrophosphate	43-46	Harvey rat sarcoma viral oncogene homolog L homeolog	Xenopus laevis	196-201
17176109-6	2006	The hydrophilic FPP analogues p-NO2-AGPP, p-CN-AGPP, and Isox-GPP are H-Ras function inhibitors (RFIs) and serve as lead compounds for a unique class of potential anticancer therapeutics.	farnesyl pyrophosphate	16-19	Harvey rat sarcoma viral oncogene homolog L homeolog	Xenopus laevis	70-75
17317725-5	2007	Mevalonate, the direct metabolite of HMG CoA reductase, and farnesyl pyrophosphate and geranylgeranyl-pyrophosphate, intermediates of the mevalonate pathway, significantly reversed the inhibitory effect of statins on COX-2.	farnesyl pyrophosphate	60-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	217-222
17158648-12	2007	Cotreatment of the cells with atorvastatin and FPP reversed the suppressive effect of atorvastatin on ACE.	farnesyl pyrophosphate	47-50	angiotensin I converting enzyme	Homo sapiens	102-105
17477829-1	2007	A mix-and-read FlashPlate (PerkinElmer, Waltham, MA) assay for the enzyme farnesyl pyrophosphate (FPP) synthase (FPPS) was developed to rapidly measure both steps in the synthesis of FPP from dimethylallyl pyrophosphate (DMAPP).	farnesyl pyrophosphate	98-101	farnesyl diphosphate synthase	Homo sapiens	113-117
17283095-5	2007	For endogenous farnesol, we created a knockout mutation in DPP3, the gene encoding a phosphatase which converts farnesyl pyrophosphate to farnesol.	farnesyl pyrophosphate	112-134	dipeptidylpeptidase 3	Mus musculus	59-63
17245169-15	2007	These lovastatin-induced changes in tPA and PAI-1 production were significantly reversed by the addition of MVA, GGPP, and FPP.	farnesyl pyrophosphate	123-126	serpin family E member 1	Homo sapiens	44-49
16418295-4	2006	We identified the terpene synthase TPS10 that forms (E)-beta-farnesene, (E)-alpha-bergamotene, and other herbivory-induced sesquiterpene hydrocarbons from the substrate farnesyl diphosphate.	farnesyl pyrophosphate	169-189	(E)-beta-farnesene synthase	Zea mays	35-40
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	farnesyl pyrophosphate	246-249	interleukin 1 beta	Homo sapiens	68-85
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	farnesyl pyrophosphate	246-249	interleukin 1 beta	Homo sapiens	87-95
16956297-1	2006	Farnesyl pyrophosphate synthase (FPPS) catalyses the formation of a key cellular intermediate in isoprenoid metabolic pathways, farnesyl pyrophosphate, by the sequential head-to-tail condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP).	farnesyl pyrophosphate	128-150	farnesyl diphosphate synthase	Homo sapiens	0-31
16956297-1	2006	Farnesyl pyrophosphate synthase (FPPS) catalyses the formation of a key cellular intermediate in isoprenoid metabolic pathways, farnesyl pyrophosphate, by the sequential head-to-tail condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP).	farnesyl pyrophosphate	128-150	farnesyl diphosphate synthase	Homo sapiens	33-37
16848430-2	2006	Farnesyl diphosphate analogues bearing omega-azide or omega-alkyne moieties were attached to the cysteine residue in Cys-Val-Ile-Ala motifs at the C-termini of engineered versions of green fluorescent protein (GFP) and glutathione S-transferase (GST) by protein farnesyltransferase.	farnesyl pyrophosphate	0-20	glutathione S-transferase kappa 1	Homo sapiens	219-244
16848430-2	2006	Farnesyl diphosphate analogues bearing omega-azide or omega-alkyne moieties were attached to the cysteine residue in Cys-Val-Ile-Ala motifs at the C-termini of engineered versions of green fluorescent protein (GFP) and glutathione S-transferase (GST) by protein farnesyltransferase.	farnesyl pyrophosphate	0-20	glutathione S-transferase kappa 1	Homo sapiens	246-249
16297849-3	2006	To understand the complex TPS4 reaction mechanism, we modeled the active site cavity and conducted docking simulations with the substrate farnesyl diphosphate, several predicted carbocation intermediates, and the final reaction products.	farnesyl pyrophosphate	138-158	terpene synthase 4	Zea mays	26-30
16476765-4	2006	We demonstrate that the isoprenoid geranylgeranyl-pyrophosphate (GGPP) mediates proliferation, whereas both GGPP and its precursor, farnesyl-PP, regulate the Th1 differentiation of myelin-reactive T cells.	farnesyl pyrophosphate	132-143	negative elongation factor complex member C/D	Homo sapiens	158-161
16221687-11	2005	FPP prevented the increase in FAS mRNA in mevalonate-depleted cells without altering SREBP-2 activation.	farnesyl pyrophosphate	0-3	fatty acid synthase	Homo sapiens	30-33
15611087-9	2005	GM-CSF-induced p38 MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF-induced p38 MAPK phosphorylation by statins.	farnesyl pyrophosphate	138-160	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
15817453-6	2005	Addition of mevalonate, GGPP or farnesyl pyrophosphate completely blocked the statin-induced increase in ABCA1 expression and apoAI-mediated cholesterol efflux.	farnesyl pyrophosphate	32-54	ATP binding cassette subfamily A member 1	Homo sapiens	105-110
15879517-4	2005	Flv-induced down-regulation of NCX1 mRNA was also cancelled by farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), suggesting an involvement of small G-proteins.	farnesyl pyrophosphate	63-85	solute carrier family 8 member A1	Rattus norvegicus	31-35
15879517-4	2005	Flv-induced down-regulation of NCX1 mRNA was also cancelled by farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), suggesting an involvement of small G-proteins.	farnesyl pyrophosphate	87-90	solute carrier family 8 member A1	Rattus norvegicus	31-35
15879517-8	2005	Western blot analyses revealed that membrane-associated RhoB, which is isoprenylated by either FPP or GGPP, was decreased by Flv but was increased by LPC.	farnesyl pyrophosphate	95-98	ras homolog family member B	Rattus norvegicus	56-60
15784989-5	2005	Kinetic analysis indicated that At-SPS2 prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate.	farnesyl pyrophosphate	78-98	solanesyl diphosphate synthase 2	Arabidopsis thaliana	32-39
15611087-9	2005	GM-CSF-induced p38 MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF-induced p38 MAPK phosphorylation by statins.	farnesyl pyrophosphate	138-160	mitogen-activated protein kinase 14	Mus musculus	15-18
15611087-9	2005	GM-CSF-induced p38 MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF-induced p38 MAPK phosphorylation by statins.	farnesyl pyrophosphate	138-160	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	223-229
15611087-9	2005	GM-CSF-induced p38 MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF-induced p38 MAPK phosphorylation by statins.	farnesyl pyrophosphate	138-160	mitogen-activated protein kinase 14	Mus musculus	238-241
15262179-13	2004	Fpp counteracted simvastatin-induced Ras/Raf/ERK inactivation.	farnesyl pyrophosphate	0-3	zinc fingers and homeoboxes 2	Homo sapiens	41-44
15690306-5	2005	Pitavastatin, simvastatin, and atorvastatin each significantly increased PON1 promoter activity, and the transactivation by pitavastatin was abrogated by mevalonic acid and farnesyl pyrophosphate (FPP), however, not by geranylgeranyl pyrophosphate.	farnesyl pyrophosphate	197-200	paraoxonase 1	Homo sapiens	73-77
15262179-13	2004	Fpp counteracted simvastatin-induced Ras/Raf/ERK inactivation.	farnesyl pyrophosphate	0-3	mitogen-activated protein kinase 1	Homo sapiens	45-48
12884273-0	2003	Farnesyl pyrophosphate promotes and is essential for the binding of RACK1 with beta-tubulin.	farnesyl pyrophosphate	0-22	receptor for activated C kinase 1	Mus musculus	68-73
15110773-1	2004	Dehydrodolichyl diphosphate (DedolPP) synthase catalyzes the sequential condensation of isopentenyl diphosphate with farnesyl diphosphate to synthesize DedolPP, a biosynthetic precursor for dolichol which plays an important role as a sugar-carrier lipid in the biosynthesis of glycoprotein in eukaryotic cells.	farnesyl pyrophosphate	117-137	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	0-46
15075399-4	2004	The encoded enzymes, TPS4 and TPS5, each formed the same complex mixture of sesquiterpenes from the precursor farnesyl diphosphate but with different proportions of products.	farnesyl pyrophosphate	110-130	terpene synthase 4	Zea mays	21-25
15075399-4	2004	The encoded enzymes, TPS4 and TPS5, each formed the same complex mixture of sesquiterpenes from the precursor farnesyl diphosphate but with different proportions of products.	farnesyl pyrophosphate	110-130	Inactive sesquithujene synthase	Zea mays	30-34
15039989-9	2004	In contrast, the enhancement effect of farnesyl pyrophosphate on the kinase activity of PKCdelta was sustained in the presence of RACK1.	farnesyl pyrophosphate	39-61	protein kinase C, delta	Mus musculus	88-96
15039989-9	2004	In contrast, the enhancement effect of farnesyl pyrophosphate on the kinase activity of PKCdelta was sustained in the presence of RACK1.	farnesyl pyrophosphate	39-61	receptor for activated C kinase 1	Mus musculus	130-135
15039989-10	2004	That is, farnesyl pyrophosphate may function as a signal to induce the kinase activity of PKCdelta in PTPase 1B/RACK1/PKCdelta complex but geranylgeranyl pyrophosphate may not for PTPase 1B.	farnesyl pyrophosphate	9-31	protein kinase C, delta	Mus musculus	90-98
15039989-10	2004	That is, farnesyl pyrophosphate may function as a signal to induce the kinase activity of PKCdelta in PTPase 1B/RACK1/PKCdelta complex but geranylgeranyl pyrophosphate may not for PTPase 1B.	farnesyl pyrophosphate	9-31	receptor for activated C kinase 1	Mus musculus	112-117
15039989-10	2004	That is, farnesyl pyrophosphate may function as a signal to induce the kinase activity of PKCdelta in PTPase 1B/RACK1/PKCdelta complex but geranylgeranyl pyrophosphate may not for PTPase 1B.	farnesyl pyrophosphate	9-31	protein kinase C, delta	Mus musculus	118-126
14985133-2	2004	Since GGPP is synthesized from isopentenyl pyrophosphate (IPP) and farnesyl pyrophosphate (FPP) by GGPP synthase, we analyzed the regulatory roles of GGPP synthase in the proliferation of FRTL-5 cells stimulated by thyrotropin and insulin in the presence of 5% calf serum (TSH+Ins).	farnesyl pyrophosphate	91-94	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	99-112
14644448-3	2003	This effect is specific for SOCS-3 and could be blocked by mevalonate, farnesyl pyrophosphate and geranylgeranyl pyrophosphate, while it was not affected by inhibitors of protein kinase C and A, mitogen-activated protein/extracellular signal-regulated kinase kinase, p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, Src, Raf and Rho kinase.	farnesyl pyrophosphate	71-93	suppressor of cytokine signaling 3	Homo sapiens	28-34
15135256-5	2004	Also, addition of isoprenoids such as farnesyl pyrophosphate (Fpp) or geranylgeranyl pyrophosphate (GGpp) fully overcame the inhibitory effect of rosuvastatin on MMP-7.	farnesyl pyrophosphate	38-60	matrix metallopeptidase 7	Homo sapiens	162-167
15135256-5	2004	Also, addition of isoprenoids such as farnesyl pyrophosphate (Fpp) or geranylgeranyl pyrophosphate (GGpp) fully overcame the inhibitory effect of rosuvastatin on MMP-7.	farnesyl pyrophosphate	62-65	matrix metallopeptidase 7	Homo sapiens	162-167
14672944-1	2004	Farnesyl pyrophosphate synthetase (FPPS) synthesizes farnesyl pyrophosphate through successive condensations of isopentyl pyrophosphate with dimethylallyl pyrophosphate and geranyl pyrophosphate.	farnesyl pyrophosphate	53-75	farnesyl diphosphate synthase	Homo sapiens	0-33
14672944-1	2004	Farnesyl pyrophosphate synthetase (FPPS) synthesizes farnesyl pyrophosphate through successive condensations of isopentyl pyrophosphate with dimethylallyl pyrophosphate and geranyl pyrophosphate.	farnesyl pyrophosphate	53-75	farnesyl diphosphate synthase	Homo sapiens	35-39
12884273-4	2003	Interestingly, when farnesyl pyrophosphate was added at the submicrogram level, the association between RACK1 and PEPtaxol was enhanced significantly in a dosage-dependent manner.	farnesyl pyrophosphate	20-42	receptor for activated C kinase 1	Mus musculus	104-109
12884273-5	2003	A parallel finding for the enhanced effect of farnesyl pyrophosphate on tubulin binding was established with mice RACK1 expressed in vitro.	farnesyl pyrophosphate	46-68	receptor for activated C kinase 1	Mus musculus	114-119
12884273-8	2003	These findings indicate that depletion of farnesyl pyrophosphate provides a mechanism to seal PKC signaling on the membrane with immobile RACK1 and to divert cells to aberrant growth, such as transformation.	farnesyl pyrophosphate	42-64	protein kinase C, gamma	Mus musculus	94-97
12884273-8	2003	These findings indicate that depletion of farnesyl pyrophosphate provides a mechanism to seal PKC signaling on the membrane with immobile RACK1 and to divert cells to aberrant growth, such as transformation.	farnesyl pyrophosphate	42-64	receptor for activated C kinase 1	Mus musculus	138-143
12825934-4	2003	Such good results were only obtained when using the X-ray crystallographic structure of farnesyl pyrophosphate (FPP) bound to the target enzyme, farnesyl pyrophosphate synthase (FPP synthase), to guide the initial molecular alignment.	farnesyl pyrophosphate	88-110	farnesyl diphosphate synthase	Homo sapiens	145-176
12825934-4	2003	Such good results were only obtained when using the X-ray crystallographic structure of farnesyl pyrophosphate (FPP) bound to the target enzyme, farnesyl pyrophosphate synthase (FPP synthase), to guide the initial molecular alignment.	farnesyl pyrophosphate	88-110	farnesyl diphosphate synthase	Homo sapiens	178-190
12825934-4	2003	Such good results were only obtained when using the X-ray crystallographic structure of farnesyl pyrophosphate (FPP) bound to the target enzyme, farnesyl pyrophosphate synthase (FPP synthase), to guide the initial molecular alignment.	farnesyl pyrophosphate	112-115	farnesyl diphosphate synthase	Homo sapiens	145-176
12825934-4	2003	Such good results were only obtained when using the X-ray crystallographic structure of farnesyl pyrophosphate (FPP) bound to the target enzyme, farnesyl pyrophosphate synthase (FPP synthase), to guide the initial molecular alignment.	farnesyl pyrophosphate	112-115	farnesyl diphosphate synthase	Homo sapiens	178-190
12839864-2	2003	Squalene synthase is the enzyme that converts farnesyl pyrophosphate to squalene in the cholesterol biosynthesis pathway.	farnesyl pyrophosphate	46-68	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	0-17
12594306-4	2003	After adoptive macrophage transfer, FPP recipient mice transferred with macrophages from CD4(+) T cell-reconstituted mice demonstrated xenograft destruction along with massive macrophage infiltration at day 4 and complete graft destruction at day 8 postmacrophage transfer.	farnesyl pyrophosphate	36-39	CD4 antigen	Mus musculus	89-92
12758256-0	2003	Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants.	farnesyl pyrophosphate	13-33	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	56-60
12667062-1	2003	Protein farnesyl transferase (PFTase) catalyzes the reaction between farnesyl diphosphate and a protein substrate to form a thioether-linked prenylated protein.	farnesyl pyrophosphate	69-89	protein farnesyltransferase	Saccharomyces cerevisiae S288C	0-28
12667062-1	2003	Protein farnesyl transferase (PFTase) catalyzes the reaction between farnesyl diphosphate and a protein substrate to form a thioether-linked prenylated protein.	farnesyl pyrophosphate	69-89	protein farnesyltransferase	Saccharomyces cerevisiae S288C	30-36
14598891-3	2003	We have recently reported that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, which block the biosynthesis of farnesylpyrophosphate and geranylgeranylpyrophosphate, inhibit in vitro invasion of human pancreatic cancer cells.	farnesyl pyrophosphate	133-154	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	31-88
12510823-7	2002	This key post-translational modification is catalyzed by the enzyme Ras famesyltransferase (FTase), which transfers a famesyl group from farnesylpyrophosphate to the C-terminal cysteine of the Ras protein.	farnesyl pyrophosphate	137-158	H3 histone pseudogene 16	Homo sapiens	68-71
12740486-3	2003	The inhibitory effect of cerivastatin on the PDGF-BB-induced activation of ERK1/2 was fully recovered by the addition of geranylgeranyl pyrophosphate (GGPP), but not farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	190-193	mitogen activated protein kinase 3	Rattus norvegicus	75-81
12621163-9	2003	Mevalonate and farnesylpyrophosphate reduced the inhibition of ERK1/2 phosphorylation by pitavastatin.	farnesyl pyrophosphate	15-36	mitogen activated protein kinase 3	Rattus norvegicus	63-69
12510823-7	2002	This key post-translational modification is catalyzed by the enzyme Ras famesyltransferase (FTase), which transfers a famesyl group from farnesylpyrophosphate to the C-terminal cysteine of the Ras protein.	farnesyl pyrophosphate	137-158	H3 histone pseudogene 16	Homo sapiens	193-196
12454262-4	2002	However, during the last years several lines of evidence pointed to the existence of a second isoform of HMGCR localized in peroxisomes, where mevalonate is converted further to farnesyl diphosphate.	farnesyl pyrophosphate	178-198	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	105-110
12373769-2	2002	The modification is catalyzed by the enzyme, protein farnesyltransferase (PFTase), which transfers a farnesyl moiety from farnesyl diphosphate to the protein.	farnesyl pyrophosphate	122-142	protein farnesyltransferase	Saccharomyces cerevisiae S288C	45-72
12501010-8	2002	The mechanism by which CRV inhibits PAI-1 expression appears to be directly associated with geranylgeranylation of some cell proteins, since the inhibitory effect on PAI-1 expression can be reversed by geranylgeranyl-pyrophosphate but not by farnesyl-pyrophosphate.	farnesyl pyrophosphate	242-264	serpin family E member 1	Homo sapiens	36-41
12501010-8	2002	The mechanism by which CRV inhibits PAI-1 expression appears to be directly associated with geranylgeranylation of some cell proteins, since the inhibitory effect on PAI-1 expression can be reversed by geranylgeranyl-pyrophosphate but not by farnesyl-pyrophosphate.	farnesyl pyrophosphate	242-264	serpin family E member 1	Homo sapiens	166-171
12427032-4	2002	Studies utilizing specific isoprenoid pyrophosphates in mevalonate-depleted cells reveal that farnesyl pyrophosphate (FPP) restores Ras processing and prevents RhoB upregulation while geranylgeranyl pyrophosphate (GGPP) restores Rap1a processing and prevents RhoA and RhoB upregulation.	farnesyl pyrophosphate	94-116	ras homolog family member B	Homo sapiens	160-164
12427032-4	2002	Studies utilizing specific isoprenoid pyrophosphates in mevalonate-depleted cells reveal that farnesyl pyrophosphate (FPP) restores Ras processing and prevents RhoB upregulation while geranylgeranyl pyrophosphate (GGPP) restores Rap1a processing and prevents RhoA and RhoB upregulation.	farnesyl pyrophosphate	94-116	RAP1A, member of RAS oncogene family	Homo sapiens	229-234
12427032-4	2002	Studies utilizing specific isoprenoid pyrophosphates in mevalonate-depleted cells reveal that farnesyl pyrophosphate (FPP) restores Ras processing and prevents RhoB upregulation while geranylgeranyl pyrophosphate (GGPP) restores Rap1a processing and prevents RhoA and RhoB upregulation.	farnesyl pyrophosphate	94-116	ras homolog family member A	Homo sapiens	259-263
12427032-4	2002	Studies utilizing specific isoprenoid pyrophosphates in mevalonate-depleted cells reveal that farnesyl pyrophosphate (FPP) restores Ras processing and prevents RhoB upregulation while geranylgeranyl pyrophosphate (GGPP) restores Rap1a processing and prevents RhoA and RhoB upregulation.	farnesyl pyrophosphate	94-116	ras homolog family member B	Homo sapiens	268-272
12427032-4	2002	Studies utilizing specific isoprenoid pyrophosphates in mevalonate-depleted cells reveal that farnesyl pyrophosphate (FPP) restores Ras processing and prevents RhoB upregulation while geranylgeranyl pyrophosphate (GGPP) restores Rap1a processing and prevents RhoA and RhoB upregulation.	farnesyl pyrophosphate	118-121	ras homolog family member B	Homo sapiens	160-164
12427032-4	2002	Studies utilizing specific isoprenoid pyrophosphates in mevalonate-depleted cells reveal that farnesyl pyrophosphate (FPP) restores Ras processing and prevents RhoB upregulation while geranylgeranyl pyrophosphate (GGPP) restores Rap1a processing and prevents RhoA and RhoB upregulation.	farnesyl pyrophosphate	118-121	RAP1A, member of RAS oncogene family	Homo sapiens	229-234
12427032-4	2002	Studies utilizing specific isoprenoid pyrophosphates in mevalonate-depleted cells reveal that farnesyl pyrophosphate (FPP) restores Ras processing and prevents RhoB upregulation while geranylgeranyl pyrophosphate (GGPP) restores Rap1a processing and prevents RhoA and RhoB upregulation.	farnesyl pyrophosphate	118-121	ras homolog family member A	Homo sapiens	259-263
12427032-4	2002	Studies utilizing specific isoprenoid pyrophosphates in mevalonate-depleted cells reveal that farnesyl pyrophosphate (FPP) restores Ras processing and prevents RhoB upregulation while geranylgeranyl pyrophosphate (GGPP) restores Rap1a processing and prevents RhoA and RhoB upregulation.	farnesyl pyrophosphate	118-121	ras homolog family member B	Homo sapiens	268-272
12427032-5	2002	Either FPP or GGPP completely prevents lovastatin-induced upregulation of RhoB mRNA.	farnesyl pyrophosphate	7-10	ras homolog family member B	Homo sapiens	74-78
12410604-11	2002	Densitometer analysis revealed that at nanogram concentration, farnesyl pyrophosphate inhibited the binding of S-Ras with KSR competently, but geranylgeranyl pyrophosphate did not.	farnesyl pyrophosphate	63-85	kinase suppressor of ras 1	Mus musculus	122-125
12410604-12	2002	The present study provides the evidence that decrease of the concentration of farnesyl pyrophosphate to sub-microgram levels lower the affinity of Ras proteins with KSR in the signaling pathway.	farnesyl pyrophosphate	78-100	kinase suppressor of ras 1	Mus musculus	165-168
12373769-2	2002	The modification is catalyzed by the enzyme, protein farnesyltransferase (PFTase), which transfers a farnesyl moiety from farnesyl diphosphate to the protein.	farnesyl pyrophosphate	122-142	protein farnesyltransferase	Saccharomyces cerevisiae S288C	74-80
11950701-2	2002	It inhibits the biosynthesis of cholesterol and its precursors: farnesyl pyrophosphate and geranylgeranyl pyrophosphate (GGPP), which are involved in Ras and RhoA cell signaling, respectively.	farnesyl pyrophosphate	64-86	ras homolog family member A	Gallus gallus	158-162
12137537-2	2002	Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphosphate (PSPP) and the subsequent rearrangement and NADPH-dependent reduction of PSPP to squalene (SQ).	farnesyl pyrophosphate	73-93	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
12137537-2	2002	Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphosphate (PSPP) and the subsequent rearrangement and NADPH-dependent reduction of PSPP to squalene (SQ).	farnesyl pyrophosphate	73-93	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	19-24
12137537-2	2002	Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphosphate (PSPP) and the subsequent rearrangement and NADPH-dependent reduction of PSPP to squalene (SQ).	farnesyl pyrophosphate	95-98	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
12137537-2	2002	Squalene synthase (SQase) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphosphate (PSPP) and the subsequent rearrangement and NADPH-dependent reduction of PSPP to squalene (SQ).	farnesyl pyrophosphate	95-98	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	19-24
12392895-9	2002	Furthermore, farnesol, a precursor to farnesylpyrophosphate, the substrate for the farnesylation of Ras, not only reversed TGFbeta(1) inhibition of Ras localization to the membrane, but also reversed TGFbeta(1) inhibition of Galpha(i2)promoter activity.	farnesyl pyrophosphate	38-59	transforming growth factor beta 1	Gallus gallus	123-133
12392895-9	2002	Furthermore, farnesol, a precursor to farnesylpyrophosphate, the substrate for the farnesylation of Ras, not only reversed TGFbeta(1) inhibition of Ras localization to the membrane, but also reversed TGFbeta(1) inhibition of Galpha(i2)promoter activity.	farnesyl pyrophosphate	38-59	transforming growth factor beta 1	Gallus gallus	200-210
12702274-5	2002	In this context the role of the Yta7 protein, belonging to the AAA ATPase family, in the regulation of FPP flux to the dolichol branch of the mevalonate pathway is discussed, and the effect of FPP and/or derived molecules on the transcription of genes encoding the first enzyme committed to dolichol biosynthesis, i.e. cis-prenyl transferase.	farnesyl pyrophosphate	103-106	Yta7p	Saccharomyces cerevisiae S288C	32-36
12135497-9	2002	The Km values of FPPS and eAS for isopentenyl diphosphate and farnesyl diphosphate, respectively, were essentially the same for the single and fused enzymes.	farnesyl pyrophosphate	62-82	farnesyl pyrophosphate synthase 1-like	Nicotiana tabacum	17-21
11566436-2	2001	FPPS is an essential enzyme that catalyzes the synthesis of farnesyl diphosphate (FPP), which is required for cholesterol biosynthesis as well as protein prenylation.	farnesyl pyrophosphate	60-80	farnesyl diphosphate synthase	Rattus norvegicus	0-4
11430477-8	2001	A MEK (MAP kinase-ERK kinase)-specific inhibitor PD98059 alone partly and with FPP completely blocked INC-induced mineralization.	farnesyl pyrophosphate	79-82	mitogen-activated protein kinase kinase 7	Homo sapiens	2-5
11430477-8	2001	A MEK (MAP kinase-ERK kinase)-specific inhibitor PD98059 alone partly and with FPP completely blocked INC-induced mineralization.	farnesyl pyrophosphate	79-82	mitogen-activated protein kinase kinase 7	Homo sapiens	7-28
11112517-2	2000	Farnesyl diphosphate synthase (FPPase) catalyzes chain elongation of the C(5) substrate dimethylallyl diphosphate (DMAPP) to the C(15) product farnesyl diphosphate (FPP) by addition of two molecules of isopentenyl diphosphate (IPP).	farnesyl pyrophosphate	143-163	farnesyl diphosphate synthase	Homo sapiens	0-29
11334884-2	2001	It could act by inhibiting the synthesis of isoprenoids (farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP)), which are respectively essential for membrane attachment and biological activity of GTPases Ras and RhoA.	farnesyl pyrophosphate	57-78	ras homolog family member A	Homo sapiens	226-230
11334884-2	2001	It could act by inhibiting the synthesis of isoprenoids (farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP)), which are respectively essential for membrane attachment and biological activity of GTPases Ras and RhoA.	farnesyl pyrophosphate	80-83	ras homolog family member A	Homo sapiens	226-230
11299356-0	2001	The cyclization of farnesyl diphosphate and nerolidyl diphosphate by a purified recombinant delta-cadinene synthase.	farnesyl pyrophosphate	19-39	(+)-delta-cadinene synthase	Gossypium hirsutum	92-115
11008488-4	2001	SQS produces squalene, a C30 isoprenoid, in a two-step reaction in which two molecules of farnesyl diphosphate are condensed head to head.	farnesyl pyrophosphate	90-110	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-3
11112517-2	2000	Farnesyl diphosphate synthase (FPPase) catalyzes chain elongation of the C(5) substrate dimethylallyl diphosphate (DMAPP) to the C(15) product farnesyl diphosphate (FPP) by addition of two molecules of isopentenyl diphosphate (IPP).	farnesyl pyrophosphate	31-34	farnesyl diphosphate synthase	Homo sapiens	0-29
11111075-3	2000	Despite the fact that mevalonate kinase is not the rate-limiting enzyme in isoprenoid biosynthesis, its activity is subject to feedback regulation by the branch-point intermediates geranyldiphosphate, farnesyldiphosphate and geranylgeranyldiphosphate.	farnesyl pyrophosphate	201-220	mevalonate kinase	Homo sapiens	22-39
11111077-2	2000	SQS produces squalene in an unusual two-step reaction in which two molecules of farnesyl diphosphate are condensed head-to-head.	farnesyl pyrophosphate	80-100	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-3
10896663-2	2000	Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor, through a reductive dimerization of two farnesyl diphosphate (FPP) molecules.	farnesyl pyrophosphate	127-147	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
18726356-2	2000	Geranylgeranyl pyrophosphate synthase (GGPPS), which catalyzes the condensation reaction between farnesyl diphosphate and isopentenyl diphosphate, is the key enzyme for synthesizing GGPP.	farnesyl pyrophosphate	97-117	geranylgeranyl diphosphate synthase 1	Homo sapiens	0-37
18726356-2	2000	Geranylgeranyl pyrophosphate synthase (GGPPS), which catalyzes the condensation reaction between farnesyl diphosphate and isopentenyl diphosphate, is the key enzyme for synthesizing GGPP.	farnesyl pyrophosphate	97-117	geranylgeranyl diphosphate synthase 1	Homo sapiens	39-44
10952986-4	2000	The phosphorylation of farnesyl pyrophosphate appears to occur in vivo as cells with an elevated level of Nm23-H1 contained more farnesyl triphosphate than did control cells.	farnesyl pyrophosphate	23-45	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	106-113
10952986-6	2000	The phosphorylation of farnesyl pyrophosphate by Nm23 proteins could alter isoprenoid metabolism, and cells with an elevated level of Nm23 proteins were found to contain more farnesylated 46- and 24-kDa proteins than did control cells.	farnesyl pyrophosphate	23-45	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	49-53
10952986-6	2000	The phosphorylation of farnesyl pyrophosphate by Nm23 proteins could alter isoprenoid metabolism, and cells with an elevated level of Nm23 proteins were found to contain more farnesylated 46- and 24-kDa proteins than did control cells.	farnesyl pyrophosphate	23-45	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	134-138
10896663-2	2000	Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor, through a reductive dimerization of two farnesyl diphosphate (FPP) molecules.	farnesyl pyrophosphate	149-152	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
10896663-4	2000	Because FPP is located at the final branch point in the isoprenoid biosynthesis pathway, its conversion to squalene through the action of squalene synthase represents the first committed step in the formation of cholesterol, making it an attractive target for therapeutic intervention.	farnesyl pyrophosphate	8-11	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	138-155
11018290-8	2000	We suggest that formation of longer dolichols in vivo is the result of a change in the isopentenyl diphosphate/farnesyl diphosphate ratio caused by the erg20 mutation which in turn affects the activity of cis-prenyltransferase.	farnesyl pyrophosphate	111-131	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	152-157
10938353-1	2000	Farnesyl pyrophosphate synthase (FPS) catalyzes the synthesis of farnesyl pyrophosphate, a key intermediate in sterol and sesquiterpene biosynthesis.	farnesyl pyrophosphate	65-87	farnesyl pyrophosphate synthase	Solanum lycopersicum	0-31
10850665-1	2000	Sesquiterpene cyclase, the first committed step enzyme from the general isoprenoid building block farnesyl pyrophosphate (FPP) for the synthesis of phytoalexin capsidiol, was isolated from the UV-C treated leaves of Capsicum annuum.	farnesyl pyrophosphate	98-120	viridiflorene synthase	Capsicum annuum	0-21
10938353-1	2000	Farnesyl pyrophosphate synthase (FPS) catalyzes the synthesis of farnesyl pyrophosphate, a key intermediate in sterol and sesquiterpene biosynthesis.	farnesyl pyrophosphate	65-87	farnesyl pyrophosphate synthase	Solanum lycopersicum	33-36
10938353-4	2000	Consistent with farnesyl pyrophosphate requirement in sterol biosynthesis, FPS genes are ubiquitously expressed in tomato plants.	farnesyl pyrophosphate	16-38	farnesyl pyrophosphate synthase	Solanum lycopersicum	75-78
10850665-1	2000	Sesquiterpene cyclase, the first committed step enzyme from the general isoprenoid building block farnesyl pyrophosphate (FPP) for the synthesis of phytoalexin capsidiol, was isolated from the UV-C treated leaves of Capsicum annuum.	farnesyl pyrophosphate	122-125	viridiflorene synthase	Capsicum annuum	0-21
10688662-10	2000	Using the immunoprecipitated protein, we found that mammalian GGPP synthase synthesizes not only GGPP but also its metabolic precursor farnesyl diphosphate.	farnesyl pyrophosphate	135-155	geranylgeranyl diphosphate synthase 1	Homo sapiens	62-75
10751437-9	2000	These data indicated that (1) the inhibition of the intrinsic mevalonate cascade induces the apoptotic NCD with the induction of p53 followed by that of Bax, (2) the inhibition of HMG-CoA reductase concomitantly causes blockage of the translocation or redistribution of Rho small GTPase families, not Ras small GTPase, to membrane, and (3) GGPP, not FPP, is one of the essential metabolites in the mevalonate cascade for protecting neurons from H-NCD.	farnesyl pyrophosphate	350-353	BCL2 associated X, apoptosis regulator	Rattus norvegicus	153-156
10531376-4	1999	We now demonstrate that farnesyl diphosphate (FPP) is the source of the positive signal for Hmg2p degradation in yeast.	farnesyl pyrophosphate	24-44	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	92-97
10677224-1	2000	Squalene synthase catalyzes two consecutive reactions in sterol biosynthesis-the condensation of two molecules of farnesyl diphosphate (FPP) to form the cyclopropylcarbinyl intermediate presqualene diphosphate (PSPP) and the subsequent rearrangement and reduction of PSPP to form squalene.	farnesyl pyrophosphate	114-134	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
10677224-1	2000	Squalene synthase catalyzes two consecutive reactions in sterol biosynthesis-the condensation of two molecules of farnesyl diphosphate (FPP) to form the cyclopropylcarbinyl intermediate presqualene diphosphate (PSPP) and the subsequent rearrangement and reduction of PSPP to form squalene.	farnesyl pyrophosphate	136-139	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
10677224-3	2000	In addition, formation of PSPP or a prior conformational change in squalene synthase is the rate-limiting step for synthesis of squalene from FPP via PSPP in the presence of NADPH and for synthesis of PSPP in the absence of NADPH.	farnesyl pyrophosphate	142-145	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	67-84
10677224-4	2000	Squalene synthase is inhibited at high concentrations of FPP.	farnesyl pyrophosphate	57-60	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
10617861-1	2000	Preincubation of Xenopus laevis oocytes with insulin or insulin-like growth factor 1 (IGF-1) resulted in inhibition of farnesyl transferase (FTase) activity measured both in vivo (after microinjection of tritiated farnesyl pyrophosphate and Ras-CVIM into oocytes) and in extracts using a filtration assay.	farnesyl pyrophosphate	214-236	insulin S homeolog	Xenopus laevis	45-52
10617861-1	2000	Preincubation of Xenopus laevis oocytes with insulin or insulin-like growth factor 1 (IGF-1) resulted in inhibition of farnesyl transferase (FTase) activity measured both in vivo (after microinjection of tritiated farnesyl pyrophosphate and Ras-CVIM into oocytes) and in extracts using a filtration assay.	farnesyl pyrophosphate	214-236	insulin like growth factor 1 L homeolog	Xenopus laevis	56-84
10617861-1	2000	Preincubation of Xenopus laevis oocytes with insulin or insulin-like growth factor 1 (IGF-1) resulted in inhibition of farnesyl transferase (FTase) activity measured both in vivo (after microinjection of tritiated farnesyl pyrophosphate and Ras-CVIM into oocytes) and in extracts using a filtration assay.	farnesyl pyrophosphate	214-236	insulin like growth factor 1 L homeolog	Xenopus laevis	86-91
10531376-4	1999	We now demonstrate that farnesyl diphosphate (FPP) is the source of the positive signal for Hmg2p degradation in yeast.	farnesyl pyrophosphate	46-49	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	92-97
10544242-7	1999	Thus, combination of two inhibitors, at non-cytotoxic concentrations, acting on the farnesyl-pyrophosphate binding site of the farnesyltransferase and the CaaX binding site of the geranylgeranyltransferase-1 respectively is an efficient strategy for disrupting Ki-Ras tumorigenic cell proliferation.	farnesyl pyrophosphate	84-106	KRAS proto-oncogene, GTPase	Homo sapiens	261-267
10448971-5	1999	The tetrapeptide, NH2-D-Trp-D-Met-L-Phe(pCl)-L-Gla-NH2 was shown to be competitive with the isoprenyl cosubstrate, farnesyl diphosphate (FPP) but not with the peptide substrate, the C-terminal tetrapeptide of the Ras protein.	farnesyl pyrophosphate	115-135	galactosidase alpha	Homo sapiens	47-50
10521476-1	1999	Squalene synthase (SS) catalyzes the reductive head-to-head condensation of two molecules of farnesyl diphosphate to form squalene, the first specific intermediate in the cholesterol biosynthetic pathway.	farnesyl pyrophosphate	93-113	farnesyl diphosphate farnesyl transferase 1	Mus musculus	0-17
10521476-1	1999	Squalene synthase (SS) catalyzes the reductive head-to-head condensation of two molecules of farnesyl diphosphate to form squalene, the first specific intermediate in the cholesterol biosynthetic pathway.	farnesyl pyrophosphate	93-113	farnesyl diphosphate farnesyl transferase 1	Mus musculus	19-21
10823210-2	1999	[reaction: see text] Protein farnesyltransferase (PFTase) catalyzes alkylation of cysteine residues by farnesyl diphosphate (FPP).	farnesyl pyrophosphate	103-123	protein farnesyltransferase	Saccharomyces cerevisiae S288C	21-48
10823210-2	1999	[reaction: see text] Protein farnesyltransferase (PFTase) catalyzes alkylation of cysteine residues by farnesyl diphosphate (FPP).	farnesyl pyrophosphate	103-123	protein farnesyltransferase	Saccharomyces cerevisiae S288C	50-56
10823210-2	1999	[reaction: see text] Protein farnesyltransferase (PFTase) catalyzes alkylation of cysteine residues by farnesyl diphosphate (FPP).	farnesyl pyrophosphate	125-128	protein farnesyltransferase	Saccharomyces cerevisiae S288C	21-48
10823210-2	1999	[reaction: see text] Protein farnesyltransferase (PFTase) catalyzes alkylation of cysteine residues by farnesyl diphosphate (FPP).	farnesyl pyrophosphate	125-128	protein farnesyltransferase	Saccharomyces cerevisiae S288C	50-56
10484604-1	1999	Farnesyl diphosphate synthase (FPPS: EC2.5.1.10), a key enzyme in isoprenoid metabolic pathways, catalyzes the synthesis of farnesyl diphosphate (FPP) an intermediate in the biosynthesis of both sterol and non-sterol isoprenoid end products.	farnesyl pyrophosphate	124-144	farnesyl diphosphate synthase	Rattus norvegicus	0-29
10484604-1	1999	Farnesyl diphosphate synthase (FPPS: EC2.5.1.10), a key enzyme in isoprenoid metabolic pathways, catalyzes the synthesis of farnesyl diphosphate (FPP) an intermediate in the biosynthesis of both sterol and non-sterol isoprenoid end products.	farnesyl pyrophosphate	31-34	farnesyl diphosphate synthase	Rattus norvegicus	0-29
10448971-5	1999	The tetrapeptide, NH2-D-Trp-D-Met-L-Phe(pCl)-L-Gla-NH2 was shown to be competitive with the isoprenyl cosubstrate, farnesyl diphosphate (FPP) but not with the peptide substrate, the C-terminal tetrapeptide of the Ras protein.	farnesyl pyrophosphate	137-140	galactosidase alpha	Homo sapiens	47-50
10329682-13	1999	These results indicate that LPP1 and DPP1 account for most of the hydrolytic activities toward dolichyl-P-P, dolichyl-P, farnesyl-P-P, and geranylgeranyl-P-P but also suggest that yeast contain other enzymes capable of dephosphorylating these essential isoprenoid intermediates.	farnesyl pyrophosphate	121-133	phosphatidate phosphatase LPP1	Saccharomyces cerevisiae S288C	28-32
10329682-13	1999	These results indicate that LPP1 and DPP1 account for most of the hydrolytic activities toward dolichyl-P-P, dolichyl-P, farnesyl-P-P, and geranylgeranyl-P-P but also suggest that yeast contain other enzymes capable of dephosphorylating these essential isoprenoid intermediates.	farnesyl pyrophosphate	121-133	bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase	Saccharomyces cerevisiae S288C	37-41
9933024-2	1999	Several farnesyl pyrophosphate (FPP) analogues were synthesized and tested in vitro for their specificity in inhibiting squalene synthase (SS), PFT, or protein:geranylgeranyl transferase-1 (PGGT-1) activities (the latter was determined using a newly designed assay).	farnesyl pyrophosphate	8-30	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	120-137
10205288-7	1999	Concomitant addition of mevalonate, farnesylpyrophosphate and geranylgeranylpyrophosphate prevented the effects of HMG-CoA reductase inhibition resulting in rescued expression of c-Jun and c-Fos.	farnesyl pyrophosphate	36-57	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	179-184
10205288-7	1999	Concomitant addition of mevalonate, farnesylpyrophosphate and geranylgeranylpyrophosphate prevented the effects of HMG-CoA reductase inhibition resulting in rescued expression of c-Jun and c-Fos.	farnesyl pyrophosphate	36-57	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	189-194
10101267-4	1999	Both of the newly identified GGPP synthase genes from mouse and human were expressed in Escherichia coli, and their gene products displayed GGPP synthase activity when isopentenyl diphosphate and farnesyl diphosphate were used as substrates.	farnesyl pyrophosphate	196-216	geranylgeranyl diphosphate synthase 1	Mus musculus	29-42
10101267-4	1999	Both of the newly identified GGPP synthase genes from mouse and human were expressed in Escherichia coli, and their gene products displayed GGPP synthase activity when isopentenyl diphosphate and farnesyl diphosphate were used as substrates.	farnesyl pyrophosphate	196-216	geranylgeranyl diphosphate synthase 1	Mus musculus	140-153
10026212-4	1999	The GGPPSase expressed in Escherichia coli catalyzes the GGPP formation (240 nmol/min/mg) from FPP and isopentenyl diphosphate.	farnesyl pyrophosphate	95-98	geranylgeranyl diphosphate synthase 1	Homo sapiens	4-12
9933024-2	1999	Several farnesyl pyrophosphate (FPP) analogues were synthesized and tested in vitro for their specificity in inhibiting squalene synthase (SS), PFT, or protein:geranylgeranyl transferase-1 (PGGT-1) activities (the latter was determined using a newly designed assay).	farnesyl pyrophosphate	32-35	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	120-137
11674151-2	1999	When the simple sulfobetaine moiety is incorporated into compounds containing hydrophobic portions like those in farnesyl diphosphate (1) or presqualene diphosphate (2), inhibition of SS in a rat liver microsomal assay was indeed observed.	farnesyl pyrophosphate	113-133	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	184-186
9799520-3	1998	A peptide corresponding to the carboxyl terminus of H-Ras binds to FTase in the microM range (KD = 4 microM) at physiological pH; however, the peptide affinity is enhanced approximately 70-fold in a ternary complex with an enzyme-bound farnesyl diphosphate (FPP) analogue, indicating that the two substrates bind synergistically.	farnesyl pyrophosphate	236-256	HRas proto-oncogene, GTPase	Homo sapiens	52-57
9799520-3	1998	A peptide corresponding to the carboxyl terminus of H-Ras binds to FTase in the microM range (KD = 4 microM) at physiological pH; however, the peptide affinity is enhanced approximately 70-fold in a ternary complex with an enzyme-bound farnesyl diphosphate (FPP) analogue, indicating that the two substrates bind synergistically.	farnesyl pyrophosphate	258-261	HRas proto-oncogene, GTPase	Homo sapiens	52-57
9647670-2	1998	In vivo studies in mice confirmed our earlier observations that inhibition of squalene synthase by zaragozic acid A was accompanied by an increase in the incorporation of label from [3H]mevalonate into farnesyl-diphosphate (FPP)-derived isoprenoic acids (J. D. Bergstrom et al., 1993, Proc.	farnesyl pyrophosphate	202-222	farnesyl diphosphate farnesyl transferase 1	Mus musculus	78-95
9671773-4	1998	The up-regulation of eNOS by HMG-CoA reductase inhibitors is not associated with changes in serum cholesterol levels, but is reversed by cotreatment with L-mevalonate and by the downstream isoprenoid, geranylgeranyl pyrophosphate and not by farnesyl pyrophosphate.	farnesyl pyrophosphate	241-263	nitric oxide synthase 3, endothelial cell	Mus musculus	21-25
9741684-4	1998	Recombinant, purified histidine-tagged protein exhibited the enzymatic properties associated with GGPP synthase, namely the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate.	farnesyl pyrophosphate	147-167	geranylgeranyl diphosphate synthase 1	Homo sapiens	98-111
9647670-2	1998	In vivo studies in mice confirmed our earlier observations that inhibition of squalene synthase by zaragozic acid A was accompanied by an increase in the incorporation of label from [3H]mevalonate into farnesyl-diphosphate (FPP)-derived isoprenoic acids (J. D. Bergstrom et al., 1993, Proc.	farnesyl pyrophosphate	224-227	farnesyl diphosphate farnesyl transferase 1	Mus musculus	78-95
9389730-3	1997	Reversal of the inhibitory effect of lovastatin on LPS-induced iNOS expression by mevalonate and farnesyl pyrophosphate and reversal of the inhibitory effect of NaPA on LPS-induced iNOS expression by farnesyl pyrophosphate, however, suggests a role of farnesylation in the LPS-mediated induction of iNOS.	farnesyl pyrophosphate	97-119	nitric oxide synthase 2	Rattus norvegicus	63-67
9658183-2	1998	Because squalene synthase and FTase recruit farnesyl pyrophosphate as a common substrate, we modified squalene synthase (SS) inhibitors to develop FTase inhibitors.	farnesyl pyrophosphate	44-66	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	102-119
29711232-2	1998	In the case of in vitro assays it inhibits the enzyme farnesyltransferase with respect to both the peptide substrate and farnesylpyrophosphate (KI = 30 and 8 muM, respectively).	farnesyl pyrophosphate	121-142	latexin	Homo sapiens	158-161
9556058-6	1998	Mevastatin, an inhibitor of 3-hydroxy-3-methylglutatyl (HMG)-CoA reductase and hence the biosynthetic pathway required for the production of farnesyl pyrophosphate and geranylgeranyl pyrophosphate, also caused apoptosis in J774 macrophages and murine osteoclasts in vitro.	farnesyl pyrophosphate	141-163	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	28-74
9389730-3	1997	Reversal of the inhibitory effect of lovastatin on LPS-induced iNOS expression by mevalonate and farnesyl pyrophosphate and reversal of the inhibitory effect of NaPA on LPS-induced iNOS expression by farnesyl pyrophosphate, however, suggests a role of farnesylation in the LPS-mediated induction of iNOS.	farnesyl pyrophosphate	200-222	nitric oxide synthase 2	Rattus norvegicus	181-185
9389730-3	1997	Reversal of the inhibitory effect of lovastatin on LPS-induced iNOS expression by mevalonate and farnesyl pyrophosphate and reversal of the inhibitory effect of NaPA on LPS-induced iNOS expression by farnesyl pyrophosphate, however, suggests a role of farnesylation in the LPS-mediated induction of iNOS.	farnesyl pyrophosphate	200-222	nitric oxide synthase 2	Rattus norvegicus	181-185
9371780-8	1997	Finally, our data indicated that the feedback signal controlling Hmg2p ubiquitination and degradation was derived from farnesyl diphosphate, and thus implied conservation of an HMG-R degradation signal between yeast and mammals.	farnesyl pyrophosphate	119-139	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	65-70
9349257-7	1997	In vitro analysis of the enzyme activity as well as genetic complementation analysis with Erwinia uredovora crt gene cluster expressed in Escherichia coli showed that the GGPS6 gene most certainly encodes a GGPP synthase catalyzing the conversion of farnesyl pyrophosphate to GGPP.	farnesyl pyrophosphate	250-272	geranylgeranyl pyrophosphate synthase 6	Arabidopsis thaliana	171-176
9295271-3	1997	The crystal structures of 5-epi-aristolochene synthase, a sesquiterpene cyclase from tobacco, alone and complexed separately with two farnesyl diphosphate analogs were analyzed.	farnesyl pyrophosphate	134-154	5-epi-aristolochene synthase-like	Nicotiana tabacum	26-54
9152381-1	1997	Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl pyrophosphate to form squalene and is the first committed step in sterol synthesis.	farnesyl pyrophosphate	75-97	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	0-17
9186913-3	1997	The strain defective in the farnesyl diphosphate (FPP) synthase, (coded by the erg20-2 gene) required the presence of exogenous FPP for synthesis of dehydrodolichols to occur in vitro.	farnesyl pyrophosphate	50-53	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	79-84
9186913-4	1997	Overexpression of the ERG20 gene restored synthesis of polyprenols in vitro indicating that FPP is the allylic "starter" for cis-prenyltransferase in yeast.	farnesyl pyrophosphate	92-95	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	22-27
8908154-10	1996	These results suggest that lovastatin inhibits the transcription of type-I SCR gene by affecting mevalonate metabolism, possibly through the farnesyl-pyrophosphate related end-product(s) in the THP-1-derived macrophages.	farnesyl pyrophosphate	141-163	GLI family zinc finger 2	Homo sapiens	194-199
11667783-1	1996	The novel farnesyl diphosphate (FPP) analog 3-cyclopropyl-3-desmethylfarnesyl diphosphate (3-cpFPP, 1) was designed as a potential mechanism-based inhibitor of the FPP-utilizing enzyme protein-farnesyl transferase (PFTase).	farnesyl pyrophosphate	10-30	protein farnesyltransferase	Saccharomyces cerevisiae S288C	185-213
11667783-1	1996	The novel farnesyl diphosphate (FPP) analog 3-cyclopropyl-3-desmethylfarnesyl diphosphate (3-cpFPP, 1) was designed as a potential mechanism-based inhibitor of the FPP-utilizing enzyme protein-farnesyl transferase (PFTase).	farnesyl pyrophosphate	10-30	protein farnesyltransferase	Saccharomyces cerevisiae S288C	215-221
11667783-1	1996	The novel farnesyl diphosphate (FPP) analog 3-cyclopropyl-3-desmethylfarnesyl diphosphate (3-cpFPP, 1) was designed as a potential mechanism-based inhibitor of the FPP-utilizing enzyme protein-farnesyl transferase (PFTase).	farnesyl pyrophosphate	32-35	protein farnesyltransferase	Saccharomyces cerevisiae S288C	185-213
11667783-1	1996	The novel farnesyl diphosphate (FPP) analog 3-cyclopropyl-3-desmethylfarnesyl diphosphate (3-cpFPP, 1) was designed as a potential mechanism-based inhibitor of the FPP-utilizing enzyme protein-farnesyl transferase (PFTase).	farnesyl pyrophosphate	32-35	protein farnesyltransferase	Saccharomyces cerevisiae S288C	215-221
9083051-1	1997	Farnesyl diphosphate, the substrate for squalene synthase, accumulates in the presence of zaragozic acid A, a squalene synthase inhibitor.	farnesyl pyrophosphate	0-20	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	40-57
9083051-1	1997	Farnesyl diphosphate, the substrate for squalene synthase, accumulates in the presence of zaragozic acid A, a squalene synthase inhibitor.	farnesyl pyrophosphate	0-20	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	110-127
9113105-2	1997	Squalene synthetase (SQS) catalyzes the head-to-head condensation of two molecules of farnesyl pyrophosphate (FPP) to form squalene.	farnesyl pyrophosphate	86-108	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-19
9113105-2	1997	Squalene synthetase (SQS) catalyzes the head-to-head condensation of two molecules of farnesyl pyrophosphate (FPP) to form squalene.	farnesyl pyrophosphate	110-113	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-19
11667728-0	1996	Photoactive Analogs of Farnesyl Pyrophosphate Containing Benzoylbenzoate Esters: Synthesis and Application to Photoaffinity Labeling of Yeast Protein Farnesyltransferase.	farnesyl pyrophosphate	23-45	protein farnesyltransferase	Saccharomyces cerevisiae S288C	142-169
8904844-7	1996	Heterologous expression of this second cDNA produced a 64 kD protein that catalyzed the cyclization of farnesyl diphosphate to (+)-delta-cadinene, the identical product produced by CAD1-C1.	farnesyl pyrophosphate	103-123	cinnamyl alcohol dehydrogenase 1	Gossypium hirsutum	181-185
8904844-8	1996	The steady-state kinetic parameters of CAD1-A were similar to CAD1-C, showing a Km of 7 mM farnesyl diphosphate and kcat of 0.039 s-1 at 30 degrees C. However, the optimal pH and Mg2+ concentration for CAD1-A activity were significantly higher than those observed for CAD1-C.	farnesyl pyrophosphate	91-111	cinnamyl alcohol dehydrogenase 1	Gossypium hirsutum	39-43
8631820-15	1996	We demonstrate that FPS2 catalyzes the two successive condensations of IPP with both DMAPP and geranyl diphosphate leading to FPP.	farnesyl pyrophosphate	126-129	farnesyl diphosphate synthase 2	Arabidopsis thaliana	20-24
8630089-6	1996	The two examples inhibited equally both steps of the SQS-catalysed reaction, as shown by parallel inhibition of 3H+ release and labelled squalene formation from [1-3H]farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	191-194	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	53-56
8671958-8	1996	In the presence of either mevalonate or the mevalonate metabolite farnesyl pyrophosphate, the lovastatin inhibition of NF-kappaB activation was substantially reversed, supporting a role for mevalonate metabolites in LPS-induced mesangial cell NF-kappaB activation.	farnesyl pyrophosphate	66-88	nuclear factor kappa B subunit 1	Homo sapiens	119-128
8671958-8	1996	In the presence of either mevalonate or the mevalonate metabolite farnesyl pyrophosphate, the lovastatin inhibition of NF-kappaB activation was substantially reversed, supporting a role for mevalonate metabolites in LPS-induced mesangial cell NF-kappaB activation.	farnesyl pyrophosphate	66-88	nuclear factor kappa B subunit 1	Homo sapiens	243-252
9125274-1	1996	Squalene synthase, the first committed enzyme for sterol synthesis, converts farnesyl pyrophosphate to squalene with presqualene pyrophosphate as an intermediate.	farnesyl pyrophosphate	77-99	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	0-17
7472655-1	1995	Farnesyl-pyrophosphate is required for the posttranslational modification of G proteins including p21 ras, prelamin A and lamin B, each of which plays an essential role in cell proliferation.	farnesyl pyrophosphate	0-22	HRas proto-oncogene, GTPase	Rattus norvegicus	98-105
18406718-3	1996	A nuclear receptor called FXR has recently been characterized that is activated by farnesyl pyrophosphate metabolites such as farnesol, farnesal, farnesoic acid, and methyl farnesoate.	farnesyl pyrophosphate	83-105	nuclear receptor subfamily 1 group H member 4	Homo sapiens	26-29
7721822-2	1995	Previous studies have demonstrated that the fungal metabolite, zaragozic acid A (ZGA-A), inhibits SQS activity by mimicking the substrate farnesyl pyrophosphate, the reaction intermediate presqualene pyrophosphate, or both, through a process that confers increased apparent potency in the presence of reduced enzyme concentrations, an observation consistent with either tight binding reversible competitive inhibition or mechanism-based irreversible inactivation.	farnesyl pyrophosphate	138-160	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	98-101
7604435-9	1995	At 500 J/m2, a significant reduction of glucose-theophylline stimulated insulin release was observed with 50-60-day-old FPP (35% to 66% of controls, P < 0.05), but not with 80-day-old FPP (93% of controls, P = ns).	farnesyl pyrophosphate	120-123	insulin	Sus scrofa	72-79
7604435-9	1995	At 500 J/m2, a significant reduction of glucose-theophylline stimulated insulin release was observed with 50-60-day-old FPP (35% to 66% of controls, P < 0.05), but not with 80-day-old FPP (93% of controls, P = ns).	farnesyl pyrophosphate	187-190	insulin	Sus scrofa	72-79
7494090-2	1995	FTase catalyzes the transfer of a farnesyl group from farnesylpyrophosphate (FPP) to cysteine 185/186 at the carboxyl terminal end of ras proteins (ras p21), a reaction essential for the localization of ras p21 to the plasma membrane for their cellular functions including cell transformation in case of oncogenic ras p21.	farnesyl pyrophosphate	54-75	H3 histone pseudogene 16	Homo sapiens	152-155
7494090-2	1995	FTase catalyzes the transfer of a farnesyl group from farnesylpyrophosphate (FPP) to cysteine 185/186 at the carboxyl terminal end of ras proteins (ras p21), a reaction essential for the localization of ras p21 to the plasma membrane for their cellular functions including cell transformation in case of oncogenic ras p21.	farnesyl pyrophosphate	54-75	H3 histone pseudogene 16	Homo sapiens	207-210
7494090-2	1995	FTase catalyzes the transfer of a farnesyl group from farnesylpyrophosphate (FPP) to cysteine 185/186 at the carboxyl terminal end of ras proteins (ras p21), a reaction essential for the localization of ras p21 to the plasma membrane for their cellular functions including cell transformation in case of oncogenic ras p21.	farnesyl pyrophosphate	54-75	H3 histone pseudogene 16	Homo sapiens	207-210
7494090-2	1995	FTase catalyzes the transfer of a farnesyl group from farnesylpyrophosphate (FPP) to cysteine 185/186 at the carboxyl terminal end of ras proteins (ras p21), a reaction essential for the localization of ras p21 to the plasma membrane for their cellular functions including cell transformation in case of oncogenic ras p21.	farnesyl pyrophosphate	77-80	H3 histone pseudogene 16	Homo sapiens	152-155
7494090-2	1995	FTase catalyzes the transfer of a farnesyl group from farnesylpyrophosphate (FPP) to cysteine 185/186 at the carboxyl terminal end of ras proteins (ras p21), a reaction essential for the localization of ras p21 to the plasma membrane for their cellular functions including cell transformation in case of oncogenic ras p21.	farnesyl pyrophosphate	77-80	H3 histone pseudogene 16	Homo sapiens	207-210
7494090-2	1995	FTase catalyzes the transfer of a farnesyl group from farnesylpyrophosphate (FPP) to cysteine 185/186 at the carboxyl terminal end of ras proteins (ras p21), a reaction essential for the localization of ras p21 to the plasma membrane for their cellular functions including cell transformation in case of oncogenic ras p21.	farnesyl pyrophosphate	77-80	H3 histone pseudogene 16	Homo sapiens	207-210
8582218-4	1995	It was found that most patients (71%) with liver cirrhosis have a elevated level in serum gastrin, whereas BAO is lower than normal in all patients, and the higher the FPP, the lower the BAO is.	farnesyl pyrophosphate	168-171	gastrin	Homo sapiens	90-97
7761439-1	1995	Protein farnesyltransferase catalyzes the alkylation of cysteine in C-terminal CaaX sequences of a variety of proteins, including Ras, nuclear lamins, large G proteins, and phosphodiesterases, by farnesyl diphosphate (FPP).	farnesyl pyrophosphate	196-216	protein farnesyltransferase	Saccharomyces cerevisiae S288C	0-27
7761439-1	1995	Protein farnesyltransferase catalyzes the alkylation of cysteine in C-terminal CaaX sequences of a variety of proteins, including Ras, nuclear lamins, large G proteins, and phosphodiesterases, by farnesyl diphosphate (FPP).	farnesyl pyrophosphate	218-221	protein farnesyltransferase	Saccharomyces cerevisiae S288C	0-27
8002598-9	1994	The results furthermore suggest that the biosynthesis of 4,4"-diaponeurosporene starts with the condensation of two molecules of farnesyl diphosphate by dehydrosqualene synthase (CrtM); it is shown that the reaction product of this enzyme is dehydrosqualene and not squalene.	farnesyl pyrophosphate	129-149	AT695_RS04460	Staphylococcus aureus	153-177
7793628-8	1995	FPP mimetics from a variety of distinct structural classes, previously shown to act as competitive inhibitors of the FPP-utilizing enzyme, squalene synthetase (SQS), also inhibited PFT activity measured using this methodology, but exhibited approximately 300- to 500-fold specificity for inhibition of SQS relative to inhibition of PFT, when both enzymes were measured at their respective Km FPP concentrations, suggesting structural differences between the FPP binding sites of the two enzymes.	farnesyl pyrophosphate	0-3	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	139-158
7793628-8	1995	FPP mimetics from a variety of distinct structural classes, previously shown to act as competitive inhibitors of the FPP-utilizing enzyme, squalene synthetase (SQS), also inhibited PFT activity measured using this methodology, but exhibited approximately 300- to 500-fold specificity for inhibition of SQS relative to inhibition of PFT, when both enzymes were measured at their respective Km FPP concentrations, suggesting structural differences between the FPP binding sites of the two enzymes.	farnesyl pyrophosphate	117-120	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	139-158
7793628-8	1995	FPP mimetics from a variety of distinct structural classes, previously shown to act as competitive inhibitors of the FPP-utilizing enzyme, squalene synthetase (SQS), also inhibited PFT activity measured using this methodology, but exhibited approximately 300- to 500-fold specificity for inhibition of SQS relative to inhibition of PFT, when both enzymes were measured at their respective Km FPP concentrations, suggesting structural differences between the FPP binding sites of the two enzymes.	farnesyl pyrophosphate	117-120	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	139-158
7793628-8	1995	FPP mimetics from a variety of distinct structural classes, previously shown to act as competitive inhibitors of the FPP-utilizing enzyme, squalene synthetase (SQS), also inhibited PFT activity measured using this methodology, but exhibited approximately 300- to 500-fold specificity for inhibition of SQS relative to inhibition of PFT, when both enzymes were measured at their respective Km FPP concentrations, suggesting structural differences between the FPP binding sites of the two enzymes.	farnesyl pyrophosphate	117-120	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	139-158
7702642-0	1995	Different analogues of farnesyl pyrophosphate inhibit squalene synthase and protein:farnesyltransferase to different extents.	farnesyl pyrophosphate	23-45	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	54-71
7702642-1	1995	The inhibitory potency of farnesyl pyrophosphate analogues was investigated on two farnesyl pyrophosphate-consuming enzymes: squalene synthase, a secondary regulation site in the cholesterol synthesis pathway, and protein:farnesyl transferase, which plays a role in the function of Ras-proteins.	farnesyl pyrophosphate	26-48	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	125-142
8086404-1	1994	The synthesis of farnesyl diphosphate (FPP), a key intermediate in the isoprenoid biosynthetic pathway required for the synthesis of cholesterol and in the formation of prenylated proteins, is catalyzed by the enzyme farnesyl diphosphate synthase (FPS).	farnesyl pyrophosphate	17-37	farnesyl diphosphate synthase	Homo sapiens	217-246
8086404-1	1994	The synthesis of farnesyl diphosphate (FPP), a key intermediate in the isoprenoid biosynthetic pathway required for the synthesis of cholesterol and in the formation of prenylated proteins, is catalyzed by the enzyme farnesyl diphosphate synthase (FPS).	farnesyl pyrophosphate	39-42	farnesyl diphosphate synthase	Homo sapiens	217-246
8407887-2	1993	This key post-translational modification is catalyzed by p21ras farnesyltransferase, which transfers farnesyl from farnesylpyrophosphate to the cysteine of the CA1A2X carboxyl-terminal tetrapeptide of p21ras.	farnesyl pyrophosphate	115-136	HRas proto-oncogene, GTPase	Homo sapiens	57-63
8051156-10	1994	Farnesyl-diphosphate synthase catalyzing the formation of farnesyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate was also purified to homogeneity from the same organ by similar affinity chromatography using a geranyl diphosphate analog, O-(6-amino-1-hexyl)-P-geranylmethyl phosphonophosphate, as a ligand.	farnesyl pyrophosphate	58-78	farnesyl pyrophosphate synthase	Bos taurus	0-29
8227045-1	1993	Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl diphosphate to form squalene at the final branchpoint of the cholesterol biosynthetic pathway.	farnesyl pyrophosphate	75-95	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	0-17
8119922-3	1994	In this reaction sequence intermediate formation of farnesyl pyrophosphate (FPP) predominates, and the FPP synthase activity was studied in more detail.	farnesyl pyrophosphate	76-79	farnesyl diphosphate synthase	Rattus norvegicus	103-115
8407887-2	1993	This key post-translational modification is catalyzed by p21ras farnesyltransferase, which transfers farnesyl from farnesylpyrophosphate to the cysteine of the CA1A2X carboxyl-terminal tetrapeptide of p21ras.	farnesyl pyrophosphate	115-136	HRas proto-oncogene, GTPase	Homo sapiens	201-207
8424764-8	1993	The purified enzyme required Mg2+, showed a pH optimum of 7.8 and was most active at 50 degrees C. The Km values for farnesyl pyrophosphate and GST-CIIS (glutathione S-transferase fused to the C-terminal 12 amino acids of yeast RAS2 protein), KmFpp and KmGST CIIS, were 8.1 and 5.1 microM respectively.	farnesyl pyrophosphate	117-139	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	228-232
8419360-10	1993	The all-trans-GGPP synthase activity exhibited high affinities for its substrates, i.e. the apparent Km values for FPP and IPP were found to be 0.6 and 3.5 microM, respectively.	farnesyl pyrophosphate	115-118	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	14-27
1438319-1	1992	The initial step in the conversion of the isoprenoid intermediate farnesyl diphosphate to the sesquiterpenoid phytoalexin capsidiol in elicitor-treated tobacco tissues is catalyzed by an inducible sesquiterpene cyclase [5-epi-aristolochene synthase (EAS)].	farnesyl pyrophosphate	66-86	5-epi-aristolochene synthase-like	Nicotiana tabacum	220-248
8419946-7	1993	Inhibition of squalene synthase in cells and in vivo was accompanied by an accumulation of label from [3H]mevalonate into farnesyl diphosphate, farnesol, and organic acids.	farnesyl pyrophosphate	122-142	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	14-31
1438319-1	1992	The initial step in the conversion of the isoprenoid intermediate farnesyl diphosphate to the sesquiterpenoid phytoalexin capsidiol in elicitor-treated tobacco tissues is catalyzed by an inducible sesquiterpene cyclase [5-epi-aristolochene synthase (EAS)].	farnesyl pyrophosphate	66-86	5-epi-aristolochene synthase-like	Nicotiana tabacum	250-253
1526971-1	1992	Squalene synthase (farnesyldiphosphate:farnesyldiphosphate farnesyltransferase, EC 2.5.1.21) converts farnesyl pyrophosphate to squalene, the first metabolic step committed solely to the biosynthesis of sterols.	farnesyl pyrophosphate	102-124	squalene synthase	Cricetulus griseus	0-17
1527001-2	1992	Isolated peroxisomes were able to utilize [3H]isopentenyl diphosphate to synthesize farnesyl diphosphate, which then was utilized as substrate by both the peroxisomal squalene synthetase and cis-prenyltransferase.	farnesyl pyrophosphate	84-104	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	167-186
1678531-4	1991	Incubation of both (9R)- and (9S)-[9-3H,4,8-14]FPP with pentalenene synthase and analysis of the resulting labelled pentalenene has revealed that H-9re of FPP becomes H-8 of pentalenene, while H-9si undergoes net intramolecular transfer to the adjacent carbon, becoming H-1re (H-1 alpha) of pentalenene, as confirmed by subsequent experiments with [10-2H, 11-13C]FPP.	farnesyl pyrophosphate	47-50	H1.1 linker histone, cluster member	Homo sapiens	277-286
2124698-2	1990	In the present investigation, we identified an activity in crude soluble extracts of yeast cells that catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to yeast RAS2 protein.	farnesyl pyrophosphate	151-173	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	183-187
35625883-6	2022	Indeed, these compounds inhibit the farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway, reducing isoprenoid formation of farnesyl pyrophosphate and geranylgeranyl pyrophosphate.	farnesyl pyrophosphate	142-164	farnesyl diphosphate synthase	Homo sapiens	36-67
34667945-5	2021	We further reveal that NRF3 overexpression not only reduces lanosterol, a cholesterol precursor, but also induces the expression of the GGPS1 gene encoding an enzyme in the production of GGPP from farnesyl pyrophosphate (FPP), a lanosterol precursor.	farnesyl pyrophosphate	197-219	NFE2 like bZIP transcription factor 3	Homo sapiens	23-27
34667945-5	2021	We further reveal that NRF3 overexpression not only reduces lanosterol, a cholesterol precursor, but also induces the expression of the GGPS1 gene encoding an enzyme in the production of GGPP from farnesyl pyrophosphate (FPP), a lanosterol precursor.	farnesyl pyrophosphate	197-219	geranylgeranyl diphosphate synthase 1	Homo sapiens	136-141
34667945-5	2021	We further reveal that NRF3 overexpression not only reduces lanosterol, a cholesterol precursor, but also induces the expression of the GGPS1 gene encoding an enzyme in the production of GGPP from farnesyl pyrophosphate (FPP), a lanosterol precursor.	farnesyl pyrophosphate	221-224	NFE2 like bZIP transcription factor 3	Homo sapiens	23-27
34667945-5	2021	We further reveal that NRF3 overexpression not only reduces lanosterol, a cholesterol precursor, but also induces the expression of the GGPS1 gene encoding an enzyme in the production of GGPP from farnesyl pyrophosphate (FPP), a lanosterol precursor.	farnesyl pyrophosphate	221-224	geranylgeranyl diphosphate synthase 1	Homo sapiens	136-141
2194674-1	1990	We report the identification, purification, and characterization of a farnesyl:protein transferase that transfers the farnesyl moiety from farnesyl pyrophosphate to a cysteine in p21ras proteins.	farnesyl pyrophosphate	139-161	HRas proto-oncogene, GTPase	Rattus norvegicus	179-185
35285188-4	2022	In S. cerevisiae, the production of geranyl pyrophosphate(GPP) and farnesyl pyrophosphate(FPP) is catalyzed by a bifunctional enzyme farnesyl pyrophosphate synthetase(encoded by ERG20 gene) which is inclined to synthesize FPP essential for yeast growth.	farnesyl pyrophosphate	67-89	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	178-183
35448489-2	2022	An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the pool of farnesyl diphosphate (FPP) substrate might instead be available to initiate natural rubber synthesis.	farnesyl pyrophosphate	167-170	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	117-120
35448489-2	2022	An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the pool of farnesyl diphosphate (FPP) substrate might instead be available to initiate natural rubber synthesis.	farnesyl pyrophosphate	145-165	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	98-115
35448489-2	2022	An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the pool of farnesyl diphosphate (FPP) substrate might instead be available to initiate natural rubber synthesis.	farnesyl pyrophosphate	145-165	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	117-120
35448489-2	2022	An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the pool of farnesyl diphosphate (FPP) substrate might instead be available to initiate natural rubber synthesis.	farnesyl pyrophosphate	167-170	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	98-115
35133719-7	2022	An I106G mutant of NDPS1 exhibited a low preference for DMAPP, but a higher preference for FPP.	farnesyl pyrophosphate	91-94	dimethylallylcistransferase CPT1, chloroplastic	Solanum lycopersicum	19-24
2569235-4	1989	Studies of yeast mutants blocked in sterol biosynthesis demonstrated that the membrane association and biological activation of the yeast Ras2 protein require mevalonate, a precursor of sterols and other isoprenes such as farnesyl pyrophosphate.	farnesyl pyrophosphate	222-244	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	138-142
41173-2	1979	The complexity of the biosynthesis of squalene by microsomal squalene synthetase demanded the existence of some intermediate(s) between farnesyl pyrophosphate and squalene.	farnesyl pyrophosphate	136-158	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	61-80
16666457-8	1988	A reexamination of the data pertaining to the transient induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity (EC 1.1.1.34) in elicitor-treated cells suggested that, while the reductase activity was necessary for sesquiterpenoid biosynthesis, it functioned more to maintain a sufficient level of intermediates between mevalonate and farnesyl diphosphate rather than as a rate limiting step controlling the synthesis rate of any one class of isoprenoids.	farnesyl pyrophosphate	349-369	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Nicotiana tabacum	69-116
33930349-9	2021	Supplementation of mevalonate, geranylgeranyl pyrophosphate, or farnesyl pyrophosphate prevented the reduction in IL-1beta release, suggesting a crucial role of protein prenylation, but not cholesterol synthesis.	farnesyl pyrophosphate	64-86	interleukin 1 alpha	Mus musculus	114-122
198206-4	1977	Inversion at C-1 during hydrolysis of trans,trans-farnesyl diphosphate to trans,trans-farnesol could explain this anomaly.	farnesyl pyrophosphate	38-70	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	13-16
33901180-6	2021	Mechanistically, extracellular calcium influx and the cation channel transient receptor potential melastatin 2 (TRPM2) exhibit essential roles in FPP-induced cell death.	farnesyl pyrophosphate	146-149	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	112-117
33901180-7	2021	FPP activates TRPM2 opening for ion influx.	farnesyl pyrophosphate	0-3	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	14-19
33901180-8	2021	Furthermore, in terms of a mouse model constructing by middle cerebral artery occlusion (MCAO), FPP accumulates in the brain, which indicates the function of the FPP and TRPM2 danger signal axis in ischemic injury.	farnesyl pyrophosphate	96-99	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	170-175
32912678-3	2020	However, ERG20 has both geranyl diphosphate synthase and farnesyl diphosphate synthase activities, which can lead to metabolic flow to farnesyl diphosphate.	farnesyl pyrophosphate	57-77	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	9-14
33113804-1	2020	Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.	farnesyl pyrophosphate	159-181	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-42
33113804-1	2020	Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.	farnesyl pyrophosphate	159-181	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	44-49
33113804-1	2020	Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.	farnesyl pyrophosphate	159-181	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	51-68
31905247-6	2020	Mechanistically, the disruption of Ggps1 increased the levels of hepatic FPP and its metabolite farnesol, thereby resulting in farnesoid X receptor (FXR) activation, which modulated hepatic bile acid metabolism and reduced hepatic bile acids.	farnesyl pyrophosphate	73-76	geranylgeranyl diphosphate synthase 1	Mus musculus	35-40
31905247-6	2020	Mechanistically, the disruption of Ggps1 increased the levels of hepatic FPP and its metabolite farnesol, thereby resulting in farnesoid X receptor (FXR) activation, which modulated hepatic bile acid metabolism and reduced hepatic bile acids.	farnesyl pyrophosphate	73-76	nuclear receptor subfamily 1, group H, member 4	Mus musculus	149-152
31397499-5	2019	Supplementation with farnesyl pyrophosphate, a substrate for protein farnesylation, rescued atorvastatin-induced mutant p53 degradation in pancreatic cancer cells.	farnesyl pyrophosphate	21-43	transformation related protein 53, pseudogene	Mus musculus	120-123
32256770-0	2020	Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.	farnesyl pyrophosphate	155-177	mevalonate kinase	Homo sapiens	11-28
32256770-10	2020	The mRNA and protein expression levels of keratin 1 and involucrin were significantly decreased following interference of MVK expression, and the decrease was markedly attenuated by FPP.	farnesyl pyrophosphate	182-185	keratin 1	Homo sapiens	42-51
32256770-10	2020	The mRNA and protein expression levels of keratin 1 and involucrin were significantly decreased following interference of MVK expression, and the decrease was markedly attenuated by FPP.	farnesyl pyrophosphate	182-185	involucrin	Homo sapiens	56-66
32256770-10	2020	The mRNA and protein expression levels of keratin 1 and involucrin were significantly decreased following interference of MVK expression, and the decrease was markedly attenuated by FPP.	farnesyl pyrophosphate	182-185	mevalonate kinase	Homo sapiens	122-125
32256770-15	2020	FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42.	farnesyl pyrophosphate	0-3	mevalonate kinase	Homo sapiens	21-24
32256770-15	2020	FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42.	farnesyl pyrophosphate	0-3	HRas proto-oncogene, GTPase	Homo sapiens	97-101
32256770-15	2020	FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42.	farnesyl pyrophosphate	0-3	KRAS proto-oncogene, GTPase	Homo sapiens	103-107
32256770-15	2020	FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42.	farnesyl pyrophosphate	0-3	NRAS proto-oncogene, GTPase	Homo sapiens	109-113
32256770-15	2020	FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42.	farnesyl pyrophosphate	0-3	ras homolog family member B	Homo sapiens	122-127
32256770-15	2020	FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42.	farnesyl pyrophosphate	0-3	ras homolog family member A	Homo sapiens	129-134
32256770-15	2020	FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42.	farnesyl pyrophosphate	0-3	Rac family small GTPase 1	Homo sapiens	136-140
32256770-15	2020	FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42.	farnesyl pyrophosphate	0-3	cell division cycle 42	Homo sapiens	145-150
31689467-4	2020	A F96C mutation in ERG20 (farnesyl diphosphate synthase of yeast) was conducted to obtain mERG20 which can function as a geranylgeranyl diphosphate synthase (GGPS).	farnesyl pyrophosphate	26-46	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	19-24
32139507-2	2020	Geranylgeranyl diphosphate synthase (GGPPS) is a branchpoint enzyme in the mevalonate (MVA) pathway that affects the ratio of FPP to GGPP.	farnesyl pyrophosphate	126-129	geranylgeranyl diphosphate synthase 1	Homo sapiens	0-35
32139507-2	2020	Geranylgeranyl diphosphate synthase (GGPPS) is a branchpoint enzyme in the mevalonate (MVA) pathway that affects the ratio of FPP to GGPP.	farnesyl pyrophosphate	126-129	geranylgeranyl diphosphate synthase 1	Homo sapiens	37-42
32043190-4	2020	With this method, single and double mutations of the essential gene ERG20 (encoding farnesyl diphosphate synthase) in S. cerevisiae were successfully constructed with high efficiencies of 100%.	farnesyl pyrophosphate	84-104	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	68-73
31958566-4	2020	Here, we stimulated the activity of the mevalonate pathway in T. atroviride P1 by expressing the Saccharomyces cerevisiae ERG20 gene coding for farnesyl pyrophosphate (FPP) synthase, a key enzyme of this pathway.	farnesyl pyrophosphate	144-166	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	122-127
31958566-4	2020	Here, we stimulated the activity of the mevalonate pathway in T. atroviride P1 by expressing the Saccharomyces cerevisiae ERG20 gene coding for farnesyl pyrophosphate (FPP) synthase, a key enzyme of this pathway.	farnesyl pyrophosphate	168-171	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	122-127
31958566-5	2020	ERG20-expressing Trichoderma strains showed higher activities of FPP synthase and squalene synthase, the principal recipient of FPP in the mevalonate pathway.	farnesyl pyrophosphate	65-68	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	0-5
31958566-5	2020	ERG20-expressing Trichoderma strains showed higher activities of FPP synthase and squalene synthase, the principal recipient of FPP in the mevalonate pathway.	farnesyl pyrophosphate	128-131	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	0-5
31547812-6	2019	In addition, we found that farnesyl diphosphate (FPP) accumulation by down-regulation of ERG9 expression and deletion of LPP1 and DPP1 did not improve alpha-Terpineol production.	farnesyl pyrophosphate	27-47	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	89-93
31612282-7	2019	However, 1 muM farnesyl pyrophosphate, an intrinsic lipid metabolite agonist, induced similar level of slow activations in WT and p.A628T.	farnesyl pyrophosphate	15-37	latexin	Homo sapiens	11-14
31547812-6	2019	In addition, we found that farnesyl diphosphate (FPP) accumulation by down-regulation of ERG9 expression and deletion of LPP1 and DPP1 did not improve alpha-Terpineol production.	farnesyl pyrophosphate	49-52	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	89-93
31332756-6	2019	Protein farnesyltransferase (PFTase) catalyzes the transfer of an isoprenoid moiety from farnesyl diphosphate (FPP) to a cysteine residue in a C-terminal CaaX motif at the C-terminus of a protein substrate.	farnesyl pyrophosphate	89-109	protein farnesyltransferase	Saccharomyces cerevisiae S288C	0-27
30374976-6	2019	GGPP synthase (GGPPS), the enzyme that converts FPP to GGPP, is dysregulated in humans and mice during NASH.	farnesyl pyrophosphate	48-51	geranylgeranyl diphosphate synthase 1	Homo sapiens	0-13
30374976-6	2019	GGPP synthase (GGPPS), the enzyme that converts FPP to GGPP, is dysregulated in humans and mice during NASH.	farnesyl pyrophosphate	48-51	geranylgeranyl diphosphate synthase 1	Homo sapiens	15-20
30374976-8	2019	Deletion or knockdown of GGPPS favors FPP prenylation (farnesylation) and augments the function of liver kinase B1, an upstream kinase of AMP-activated protein kinase (AMPK).	farnesyl pyrophosphate	38-41	geranylgeranyl diphosphate synthase 1	Homo sapiens	25-30
31332756-6	2019	Protein farnesyltransferase (PFTase) catalyzes the transfer of an isoprenoid moiety from farnesyl diphosphate (FPP) to a cysteine residue in a C-terminal CaaX motif at the C-terminus of a protein substrate.	farnesyl pyrophosphate	89-109	protein farnesyltransferase	Saccharomyces cerevisiae S288C	29-35
31332756-6	2019	Protein farnesyltransferase (PFTase) catalyzes the transfer of an isoprenoid moiety from farnesyl diphosphate (FPP) to a cysteine residue in a C-terminal CaaX motif at the C-terminus of a protein substrate.	farnesyl pyrophosphate	111-114	protein farnesyltransferase	Saccharomyces cerevisiae S288C	0-27
31332756-6	2019	Protein farnesyltransferase (PFTase) catalyzes the transfer of an isoprenoid moiety from farnesyl diphosphate (FPP) to a cysteine residue in a C-terminal CaaX motif at the C-terminus of a protein substrate.	farnesyl pyrophosphate	111-114	protein farnesyltransferase	Saccharomyces cerevisiae S288C	29-35
30062607-4	2018	It is able to catalyze the synthesis of geranylgeranyl pyrophosphate as a major product and of farnesyl pyrophosphate in smaller amounts, as measured by gas chromatography-mass spectrometry at an elevated temperature of 60  C. Its ability to produce two products is consistent with the fact that GACE1337 is the only short-chain isoprenyl diphosphate synthase in G. acetivorans.	farnesyl pyrophosphate	95-117	polyprenyl synthetase family protein	Geoglobus acetivorans	296-304
30524645-9	2018	Serum level of mast cell protease 1 tended to be suppressed in FPP-consumed mice compared to those in saline-treated mice.	farnesyl pyrophosphate	63-66	mast cell protease 1	Mus musculus	15-35
29158265-6	2018	Of note, topical mevastatin stimulated epithelialization and angiogenesis in vivo Mevastatin also reversed FPP-mediated induction of the GR target, the transcription factor c-Myc (a biomarker of non-healing wounds), in porcine and human wound models.	farnesyl pyrophosphate	107-110	nuclear receptor subfamily 3 group C member 1	Homo sapiens	137-139
29738536-7	2018	Co-treatment with farnesyl pyrophosphate (FPP), a CBP metabolite downstream of HMG-CoA reductase, reduces SREBP2 activation and pravastatin-induced PARP cleavage.	farnesyl pyrophosphate	18-40	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	79-96
29738536-7	2018	Co-treatment with farnesyl pyrophosphate (FPP), a CBP metabolite downstream of HMG-CoA reductase, reduces SREBP2 activation and pravastatin-induced PARP cleavage.	farnesyl pyrophosphate	18-40	sterol regulatory element binding factor 2	Mus musculus	106-112
29738536-7	2018	Co-treatment with farnesyl pyrophosphate (FPP), a CBP metabolite downstream of HMG-CoA reductase, reduces SREBP2 activation and pravastatin-induced PARP cleavage.	farnesyl pyrophosphate	18-40	poly (ADP-ribose) polymerase family, member 1	Mus musculus	148-152
29738536-7	2018	Co-treatment with farnesyl pyrophosphate (FPP), a CBP metabolite downstream of HMG-CoA reductase, reduces SREBP2 activation and pravastatin-induced PARP cleavage.	farnesyl pyrophosphate	42-45	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	79-96
29738536-7	2018	Co-treatment with farnesyl pyrophosphate (FPP), a CBP metabolite downstream of HMG-CoA reductase, reduces SREBP2 activation and pravastatin-induced PARP cleavage.	farnesyl pyrophosphate	42-45	sterol regulatory element binding factor 2	Mus musculus	106-112
29738536-7	2018	Co-treatment with farnesyl pyrophosphate (FPP), a CBP metabolite downstream of HMG-CoA reductase, reduces SREBP2 activation and pravastatin-induced PARP cleavage.	farnesyl pyrophosphate	42-45	poly (ADP-ribose) polymerase family, member 1	Mus musculus	148-152
29355536-9	2018	We close by addressing the biological question as to how farnesyl-PP levels are affected by CYP51 inhibition, and demonstrate that the regulatory mechanisms within the network work in unison to ensure they remain bounded.	farnesyl pyrophosphate	57-68	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	92-97
29158265-3	2018	Statins target the cholesterol pathway and block the synthesis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR).	farnesyl pyrophosphate	95-117	nuclear receptor subfamily 3 group C member 1	Homo sapiens	154-177
29158265-3	2018	Statins target the cholesterol pathway and block the synthesis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR).	farnesyl pyrophosphate	95-117	nuclear receptor subfamily 3 group C member 1	Homo sapiens	179-181
29158265-3	2018	Statins target the cholesterol pathway and block the synthesis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR).	farnesyl pyrophosphate	119-122	nuclear receptor subfamily 3 group C member 1	Homo sapiens	154-177
29158265-3	2018	Statins target the cholesterol pathway and block the synthesis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR).	farnesyl pyrophosphate	119-122	nuclear receptor subfamily 3 group C member 1	Homo sapiens	179-181
29158265-6	2018	Of note, topical mevastatin stimulated epithelialization and angiogenesis in vivo Mevastatin also reversed FPP-mediated induction of the GR target, the transcription factor c-Myc (a biomarker of non-healing wounds), in porcine and human wound models.	farnesyl pyrophosphate	107-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	173-178
29319354-12	2018	The MCTP + simvastatin + mevalonate group, MCTP + simvastatin+ FPP group, and MCTP + simvastatin + FPP + GGPP group showed increased mRNA levels of RhoA and ROCK1, as well as increased protein levels of RhoA, compared to the MCTP + simvastatin group.	farnesyl pyrophosphate	63-66	ras homolog family member A	Homo sapiens	148-152
29319354-12	2018	The MCTP + simvastatin + mevalonate group, MCTP + simvastatin+ FPP group, and MCTP + simvastatin + FPP + GGPP group showed increased mRNA levels of RhoA and ROCK1, as well as increased protein levels of RhoA, compared to the MCTP + simvastatin group.	farnesyl pyrophosphate	99-102	ras homolog family member A	Homo sapiens	148-152
29683099-7	2018	Non-nitrogen containing bisphosphonates inhibit farnesyl diphosphate synthase which produces farnesyl pyrophosphate.	farnesyl pyrophosphate	93-115	farnesyl diphosphate synthase	Homo sapiens	48-77
29319354-12	2018	The MCTP + simvastatin + mevalonate group, MCTP + simvastatin+ FPP group, and MCTP + simvastatin + FPP + GGPP group showed increased mRNA levels of RhoA and ROCK1, as well as increased protein levels of RhoA, compared to the MCTP + simvastatin group.	farnesyl pyrophosphate	99-102	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	157-162
29319354-12	2018	The MCTP + simvastatin + mevalonate group, MCTP + simvastatin+ FPP group, and MCTP + simvastatin + FPP + GGPP group showed increased mRNA levels of RhoA and ROCK1, as well as increased protein levels of RhoA, compared to the MCTP + simvastatin group.	farnesyl pyrophosphate	99-102	ras homolog family member A	Homo sapiens	203-207
29319354-15	2018	Simvastatin decreased RhoA/ROCK1 overexpression by inhibition of mevalonate, FPP, and GGPP synthesis.	farnesyl pyrophosphate	77-80	ras homolog family member A	Homo sapiens	22-26
29319354-15	2018	Simvastatin decreased RhoA/ROCK1 overexpression by inhibition of mevalonate, FPP, and GGPP synthesis.	farnesyl pyrophosphate	77-80	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	27-32
28843826-5	2017	Mechanically, ZA inhibited SREBP-1c-mediated de novo lipogenesis through suppressing RhoA activation via decreasing farnesyl diphosphate and geranylgeranyl diphosphate levels.	farnesyl pyrophosphate	116-136	sterol regulatory element binding transcription factor 1	Mus musculus	27-35
29251770-2	2018	Here, we describe the activity of human viperin with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis.	farnesyl pyrophosphate	121-143	radical S-adenosyl methionine domain containing 2	Homo sapiens	40-47
29290764-7	2018	We hypothesized that AA3 deacetylates NAFC and NAGGC, and generated farnesylcysteine (FC) and geranylgeranylcysteine (GGC) that are used in HCC cells for the regeneration of farnesylpyrophosphate and geranylgeranylpyrophosphate providing the prenyl (farnesyl or geranylgeranyl) group for Ras prenylation required for Ras membrane association.	farnesyl pyrophosphate	174-195	aminoacylase 3	Homo sapiens	21-24
28559264-5	2017	C7S showed high activity against the T. gondii bifunctional farnesyl diphosphate (FPP)/geranylgeranyl diphosphate (GGPP) synthase (TgFPPS), which catalyzes the formation of FPP and GGPP (50% inhibitory concentration [IC50] = 31 +- 0.01 nM [mean +- standard deviation]), and modest effect against the human FPPS (IC50 = 1.3 +- 0.5 muM).	farnesyl pyrophosphate	60-80	farnesyl diphosphate synthase	Homo sapiens	133-137
28809830-2	2017	DHDDS (dehydrodolichyl diphosphate synthase) is a eukaryotic long-chain cis-PT (forming cis double bonds from the condensation reaction) that catalyzes chain elongation of farnesyl diphosphate (FPP, an allylic diphosphate) via multiple condensations with isopentenyl diphosphate (IPP).	farnesyl pyrophosphate	172-192	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	0-5
28809830-2	2017	DHDDS (dehydrodolichyl diphosphate synthase) is a eukaryotic long-chain cis-PT (forming cis double bonds from the condensation reaction) that catalyzes chain elongation of farnesyl diphosphate (FPP, an allylic diphosphate) via multiple condensations with isopentenyl diphosphate (IPP).	farnesyl pyrophosphate	172-192	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	7-43
28809830-2	2017	DHDDS (dehydrodolichyl diphosphate synthase) is a eukaryotic long-chain cis-PT (forming cis double bonds from the condensation reaction) that catalyzes chain elongation of farnesyl diphosphate (FPP, an allylic diphosphate) via multiple condensations with isopentenyl diphosphate (IPP).	farnesyl pyrophosphate	194-197	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	0-5
28809830-2	2017	DHDDS (dehydrodolichyl diphosphate synthase) is a eukaryotic long-chain cis-PT (forming cis double bonds from the condensation reaction) that catalyzes chain elongation of farnesyl diphosphate (FPP, an allylic diphosphate) via multiple condensations with isopentenyl diphosphate (IPP).	farnesyl pyrophosphate	194-197	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	7-43
28559264-5	2017	C7S showed high activity against the T. gondii bifunctional farnesyl diphosphate (FPP)/geranylgeranyl diphosphate (GGPP) synthase (TgFPPS), which catalyzes the formation of FPP and GGPP (50% inhibitory concentration [IC50] = 31 +- 0.01 nM [mean +- standard deviation]), and modest effect against the human FPPS (IC50 = 1.3 +- 0.5 muM).	farnesyl pyrophosphate	82-85	farnesyl diphosphate synthase	Homo sapiens	133-137
28098152-4	2017	Here we report that the product of FPPS, farnesyl pyrophosphate (FPP), can bind to this pocket and lock the enzyme in an inactive state.	farnesyl pyrophosphate	41-63	farnesyl diphosphate synthase	Homo sapiens	35-39
28167250-3	2017	Dehydrodolichyl diphosphate synthase (DHDDS) is an eukaryotic cis prenyltransferase (cis-PT) that catalyzes chain elongation of farnesyl diphosphate via multiple condensations with isopentenyl diphosphate to form dehydrodolichyl diphosphate, a precursor for the glycosyl carrier dolichylpyrophophate involved in N-linked glycosylation.	farnesyl pyrophosphate	128-148	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	0-36
28167250-3	2017	Dehydrodolichyl diphosphate synthase (DHDDS) is an eukaryotic cis prenyltransferase (cis-PT) that catalyzes chain elongation of farnesyl diphosphate via multiple condensations with isopentenyl diphosphate to form dehydrodolichyl diphosphate, a precursor for the glycosyl carrier dolichylpyrophophate involved in N-linked glycosylation.	farnesyl pyrophosphate	128-148	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	38-43
28208018-1	2017	The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme in the mevalonate pathway, catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	44-47	farnesyl diphosphate synthase	Homo sapiens	10-41
27652005-8	2016	Increased levels of GGPP and FPP attenuated lipopolysaccharide (LPS)-induced IL-1beta production in THP-1 cells and human PBMCs in statin-treated conditions.	farnesyl pyrophosphate	29-32	interleukin 1 beta	Homo sapiens	77-85
27439540-5	2016	In the FST, FPP, Lys, and Leu significantly decreased immobility times and up-regulated brain-derived neurotrophic factor expression in brain.	farnesyl pyrophosphate	12-15	brain derived neurotrophic factor	Mus musculus	88-121
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	farnesyl pyrophosphate	13-16	tumor necrosis factor	Mus musculus	69-96
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	farnesyl pyrophosphate	13-16	interleukin 1 beta	Mus musculus	118-126
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	farnesyl pyrophosphate	13-16	interleukin 4	Mus musculus	132-136
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	farnesyl pyrophosphate	13-16	caspase 1	Mus musculus	157-166
27016018-9	2016	The findings indicate that the administration of SV can enhance GluN2B expression and GluN2B and GluN2A phosphorylation leading to augmentation of NMDAR activity through reducing FPP to increase histone acetylation of GluN2B and Src signaling.	farnesyl pyrophosphate	179-182	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	147-152
27133418-4	2016	The observation that the levels of FPP and GGPP, but not that of cholesterol, are elevated in AD patients is consistent with the finding that statins, competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, reduce FPP and GGPP levels and amyloid beta protein production in preclinical studies.	farnesyl pyrophosphate	35-38	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	177-234
26843581-6	2016	We confirmed low-level TRPV3 expression in vagal afferent neurons and observed direct activation with putative TRPV3 agonists eugenol, ethyl vanillin (EVA), and farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	161-183	transient receptor potential cation channel, subfamily V, member 3	Rattus norvegicus	111-116
26843581-6	2016	We confirmed low-level TRPV3 expression in vagal afferent neurons and observed direct activation with putative TRPV3 agonists eugenol, ethyl vanillin (EVA), and farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	185-188	transient receptor potential cation channel, subfamily V, member 3	Rattus norvegicus	111-116
27133418-4	2016	The observation that the levels of FPP and GGPP, but not that of cholesterol, are elevated in AD patients is consistent with the finding that statins, competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, reduce FPP and GGPP levels and amyloid beta protein production in preclinical studies.	farnesyl pyrophosphate	243-246	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	177-234
27336844-2	2016	Overexpression of FPPS induced cardiac hypertrophy and fibrosis in mice, accompanied by an increase in the synthesis of farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	120-142	farnesyl diphosphate synthase	Rattus norvegicus	18-22
26700959-10	2016	These results indicate that PPAPDC2 plays an important role in SQ1-mediated CAR activation, most likely by catalyzing the conversion of FPP to farnesol.	farnesyl pyrophosphate	136-139	phospholipid phosphatase 6	Rattus norvegicus	28-35
26700959-10	2016	These results indicate that PPAPDC2 plays an important role in SQ1-mediated CAR activation, most likely by catalyzing the conversion of FPP to farnesol.	farnesyl pyrophosphate	136-139	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	76-79
26898421-8	2016	Our results indicate that statins inhibit biosynthesis of FPP and GGPP and thereby down regulate signal transduction of Ras/ERK and Ras/Akt pathways.	farnesyl pyrophosphate	58-61	mitogen-activated protein kinase 1	Mus musculus	124-127
26898421-8	2016	Our results indicate that statins inhibit biosynthesis of FPP and GGPP and thereby down regulate signal transduction of Ras/ERK and Ras/Akt pathways.	farnesyl pyrophosphate	58-61	thymoma viral proto-oncogene 1	Mus musculus	136-139
26803304-4	2016	Several enzymes of gossypol biosynthesis pathway have been characterized, including 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) and farnesyl diphosphate synthase (FPS) that catalyze the formation of the precursor farnesyl diphosphate (FPP), (+)-delta-cadinene synthase (CDN) which is the first enzyme committed to gossypol biosynthesis, and the downstream enzymes of CYP706B1 and methyltransferase.	farnesyl pyrophosphate	143-163	(+)-delta-cadinene synthase	Gossypium hirsutum	252-279
26327249-5	2015	It actually inhibits the incorporation of farnesyl pyrophosphate into human H-ras proteins by the enzyme farnesyl transferase (FTase).	farnesyl pyrophosphate	42-64	HRas proto-oncogene, GTPase	Homo sapiens	76-81
26757191-7	2016	Replenishment of isoprenoid farnesyl pyrophosphate (FPP) by applying farnesol (FOH) could abolish the SV-increased phospho-NR2B in Abeta1-42-mice, but had no effect on the Abeta1-42-enhanced phospho-NR2B.	farnesyl pyrophosphate	52-55	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	123-127
26757191-7	2016	Replenishment of isoprenoid farnesyl pyrophosphate (FPP) by applying farnesol (FOH) could abolish the SV-increased phospho-NR2B in Abeta1-42-mice, but had no effect on the Abeta1-42-enhanced phospho-NR2B.	farnesyl pyrophosphate	52-55	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	199-203
26358205-7	2015	Autophagy suppression by bafilomycin A1 or RNA interference-mediated knockdown of beclin-1 and microtubule-associated protein 1 light chain 3B induced apoptotic death in statin-treated leukemic cells, an effect attenuated by the addition of mevalonate or squalene, but not farnesylpyrophosphate or geranylgeranylpyrophosphate.	farnesyl pyrophosphate	273-294	beclin 1	Homo sapiens	82-142
26781029-3	2016	The blockade of FPPS prevents the synthesis of farnesyl diphosphate and the downstream essential products.	farnesyl pyrophosphate	47-67	farnesyl diphosphate synthase	Homo sapiens	16-20
24598914-1	2014	Human farnesyl pyrophosphate synthase (hFPPS) produces farnesyl pyrophosphate, an isoprenoid essential for a variety of cellular processes.	farnesyl pyrophosphate	6-28	farnesyl diphosphate synthase	Homo sapiens	39-44
26108562-12	2015	These data reveal that greater FPP increases the role of NO in PLM-induced vasodilatation in the young, but not the old, due to reduced NO bioavailability with age.	farnesyl pyrophosphate	31-34	FXYD domain containing ion transport regulator 1	Homo sapiens	63-66
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	farnesyl pyrophosphate	106-126	terpene synthase 4	Zea mays	31-39
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	farnesyl pyrophosphate	106-126	Inactive sesquithujene synthase	Zea mays	44-48
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	farnesyl pyrophosphate	128-131	terpene synthase 4	Zea mays	31-39
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	farnesyl pyrophosphate	128-131	Inactive sesquithujene synthase	Zea mays	44-48
25304981-8	2015	Co-incubation of tissue explants with statins and farnesyl pyrophosphate (which increases the supply of dolichol intermediates), prevented statin-mediated disruption of IGF1R localization and reversed the negative effect on IGF-mediated trophoblast proliferation.	farnesyl pyrophosphate	50-72	insulin like growth factor 1 receptor	Homo sapiens	169-174
25497898-2	2015	Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production is catalyzed by 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.	farnesyl pyrophosphate	0-21	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	129-179
25497898-2	2015	Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production is catalyzed by 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.	farnesyl pyrophosphate	23-26	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	129-179
25497898-3	2015	Prenylation by FPP and GGPP is required for membrane insertion and oncogenic function of Ras- and Rho-proteins, within the stimulation of the Ras-Raf-MEK-ERK pathway.	farnesyl pyrophosphate	15-18	zinc fingers and homeoboxes 2	Homo sapiens	146-149
25497898-3	2015	Prenylation by FPP and GGPP is required for membrane insertion and oncogenic function of Ras- and Rho-proteins, within the stimulation of the Ras-Raf-MEK-ERK pathway.	farnesyl pyrophosphate	15-18	mitogen-activated protein kinase kinase 7	Homo sapiens	150-153
25497898-3	2015	Prenylation by FPP and GGPP is required for membrane insertion and oncogenic function of Ras- and Rho-proteins, within the stimulation of the Ras-Raf-MEK-ERK pathway.	farnesyl pyrophosphate	15-18	mitogen-activated protein kinase 1	Homo sapiens	154-157
26051402-0	2015	Simvastatin prevents beta-amyloid(25-35)-impaired neurogenesis in hippocampal dentate gyrus through alpha7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate.	farnesyl pyrophosphate	178-200	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	100-111
26051402-10	2015	The results indicate that the SV-treatment in Abeta25-35-mice via reduction of FPP can protect neurogenesis through alpha7nAChR-cascading PI3K-Akt and increasing BDNF, which may improve spatial cognitive function.	farnesyl pyrophosphate	79-82	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	116-127
26051402-10	2015	The results indicate that the SV-treatment in Abeta25-35-mice via reduction of FPP can protect neurogenesis through alpha7nAChR-cascading PI3K-Akt and increasing BDNF, which may improve spatial cognitive function.	farnesyl pyrophosphate	79-82	thymoma viral proto-oncogene 1	Mus musculus	143-146
26051402-10	2015	The results indicate that the SV-treatment in Abeta25-35-mice via reduction of FPP can protect neurogenesis through alpha7nAChR-cascading PI3K-Akt and increasing BDNF, which may improve spatial cognitive function.	farnesyl pyrophosphate	79-82	brain derived neurotrophic factor	Mus musculus	162-166
26425463-1	2015	Statins or 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors not only prevents the synthesis of cholesterol biosynthesis but also inhibits the synthesis of essential isoprenoid intermediates such as farnesyl pyrophosphate, geranylgeranyl pyrophosphate, isopentanyl adenosine, dolichols and polyisoprenoid side chains of ubiquinone, heme A, and nuclear lamins.	farnesyl pyrophosphate	216-238	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	11-66
25416152-2	2015	These agents act on the mevalonate pathway and inhibit synthesis of cholesterol, geranylgeranyl pyrophosphate, and farnesyl pyrophosphate, which are necessary for posttranslational modification of the Rho, Rac, and Ras superfamily of proteins.	farnesyl pyrophosphate	115-137	AKT serine/threonine kinase 1	Homo sapiens	206-209
24918807-7	2014	Further, the inhibitory effect of the statins on leptin-induced migration was shown to be modulated by the prenylation of farnesyl pyrophosphate and geranylgeranyl pyrophosphate.	farnesyl pyrophosphate	122-144	leptin	Homo sapiens	49-55
24531458-1	2014	Squalene synthase (SQS) is a divalent metal-ion-dependent enzyme that catalyzes the two-step reductive `head-to-head" condensation of two molecules of farnesyl pyrophosphate to form squalene using presqualene diphosphate (PSPP) as an intermediate.	farnesyl pyrophosphate	151-173	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
24531458-1	2014	Squalene synthase (SQS) is a divalent metal-ion-dependent enzyme that catalyzes the two-step reductive `head-to-head" condensation of two molecules of farnesyl pyrophosphate to form squalene using presqualene diphosphate (PSPP) as an intermediate.	farnesyl pyrophosphate	151-173	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	19-22
24074555-6	2013	By in vitro assays of the recombinant proteins, it was found that GhTPS1 and GhTPS2 are sesquiterpene synthases: the former converted farnesyl pyrophosphate (FPP) into beta-caryophyllene and alpha-humulene in a ratio of 2:1, whereas the latter produced several sesquiterpenes with guaia-1(10),11-diene as the major product.	farnesyl pyrophosphate	134-156	(-)-germacrene D synthase-like	Gossypium hirsutum	66-72
24777789-1	2014	Farnesyl diphosphate synthase (FPS) catalyzes the sequential head-to-tail condensation of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to produce farnesyl diphosphate (FPP, C15).	farnesyl pyrophosphate	213-233	farnesyl diphosphate synthase	Homo sapiens	0-29
24777789-1	2014	Farnesyl diphosphate synthase (FPS) catalyzes the sequential head-to-tail condensation of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to produce farnesyl diphosphate (FPP, C15).	farnesyl pyrophosphate	235-238	farnesyl diphosphate synthase	Homo sapiens	0-29
24063859-2	2013	Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase.	farnesyl pyrophosphate	23-45	farnesyl diphosphate synthase	Homo sapiens	84-96
24063859-2	2013	Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase.	farnesyl pyrophosphate	47-50	farnesyl diphosphate synthase	Homo sapiens	84-96
24074555-6	2013	By in vitro assays of the recombinant proteins, it was found that GhTPS1 and GhTPS2 are sesquiterpene synthases: the former converted farnesyl pyrophosphate (FPP) into beta-caryophyllene and alpha-humulene in a ratio of 2:1, whereas the latter produced several sesquiterpenes with guaia-1(10),11-diene as the major product.	farnesyl pyrophosphate	134-156	terpene synthase 10-like	Gossypium hirsutum	77-83
24184450-3	2013	Recombinant GhTPS1 accepted farnesyl pyrophosphate as substrate and produced (E)-beta-caryophyllene and alpha-humulene.	farnesyl pyrophosphate	28-50	(-)-germacrene D synthase-like	Gossypium hirsutum	12-18
24074555-6	2013	By in vitro assays of the recombinant proteins, it was found that GhTPS1 and GhTPS2 are sesquiterpene synthases: the former converted farnesyl pyrophosphate (FPP) into beta-caryophyllene and alpha-humulene in a ratio of 2:1, whereas the latter produced several sesquiterpenes with guaia-1(10),11-diene as the major product.	farnesyl pyrophosphate	158-161	(-)-germacrene D synthase-like	Gossypium hirsutum	66-72
24074555-6	2013	By in vitro assays of the recombinant proteins, it was found that GhTPS1 and GhTPS2 are sesquiterpene synthases: the former converted farnesyl pyrophosphate (FPP) into beta-caryophyllene and alpha-humulene in a ratio of 2:1, whereas the latter produced several sesquiterpenes with guaia-1(10),11-diene as the major product.	farnesyl pyrophosphate	158-161	terpene synthase 10-like	Gossypium hirsutum	77-83
23449454-6	2013	Statin-induced cytotoxic effects, DNA fragmentation and changes of activation of caspase-3, Akt, Erk and p38 were blocked by antioxidant (N-acetylcysteine) and metabolic products of the HMG-CoA reductase reaction, such as mevalonate, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	234-256	caspase 3	Mus musculus	81-90
23180723-5	2013	The results showed that Tg mice with overexpression of FPPS exhibited cardiac hypertrophy, fibrosis, and HF, as well as increased synthesis of farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate in heart tissue.	farnesyl pyrophosphate	143-165	farnesyl diphosphate synthetase	Mus musculus	55-59
24036394-1	2013	The reaction catalyzed by squalene synthase (EC.2.5.1.21) that converts two molecules of farnesyl pyrophosphate to squalene represents a crucial branch point of the isoprenoid pathway in diverting carbon flux towards the biosynthesis of sterols.	farnesyl pyrophosphate	89-111	squalene synthase 2	Glycine max	26-43
24209962-8	2013	Fluvastatin-induced activation of caspase-3, DNA fragmentation, and activation of LC3-II were blocked by metabolic products of the HMG-CoA reductase reaction, such as mevalonate, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	179-201	caspase 3	Mus musculus	34-43
24209962-8	2013	Fluvastatin-induced activation of caspase-3, DNA fragmentation, and activation of LC3-II were blocked by metabolic products of the HMG-CoA reductase reaction, such as mevalonate, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	203-206	caspase 3	Mus musculus	34-43
23353045-9	2013	Fura-2 calcium imaging of urothelial cells showed responses to adenosine triphosphate (100 muM) and activation of TRPV4 (4alpha-PDD, 10 muM) but not TRPV1 (capsaicin, 1 muM), TRPV3 (farnesyl pyrophosphate, 1 muM) or TRPA1 (mustard oil, 100 muM).	farnesyl pyrophosphate	182-204	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	114-119
23333605-1	2013	Farnesyl pyrophosphate synthase (FPPS EC 2.5.1.10) catalyzes the production of farnesyl pyrophosphate (FPP), which is a key precursor for many sesquiterpenoids such as floral scent and defense volatiles against herbivore attack.	farnesyl pyrophosphate	79-101	farnesyl pyrophosphate synthase 1	Musa acuminata	33-37
23354132-5	2013	The statin-induced             phosphorylation of eIF2alpha and JNK was inhibited by supplementation with components             of the mevalonate pathway, such as mevalonate, farnesyl pyrophosphate (FPP) and             geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	176-198	eukaryotic translation initiation factor 2A	Homo sapiens	50-59
23354132-5	2013	The statin-induced             phosphorylation of eIF2alpha and JNK was inhibited by supplementation with components             of the mevalonate pathway, such as mevalonate, farnesyl pyrophosphate (FPP) and             geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	176-198	mitogen-activated protein kinase 8	Homo sapiens	64-67
23354132-5	2013	The statin-induced             phosphorylation of eIF2alpha and JNK was inhibited by supplementation with components             of the mevalonate pathway, such as mevalonate, farnesyl pyrophosphate (FPP) and             geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	200-203	eukaryotic translation initiation factor 2A	Homo sapiens	50-59
23354132-5	2013	The statin-induced             phosphorylation of eIF2alpha and JNK was inhibited by supplementation with components             of the mevalonate pathway, such as mevalonate, farnesyl pyrophosphate (FPP) and             geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	200-203	mitogen-activated protein kinase 8	Homo sapiens	64-67
23449454-6	2013	Statin-induced cytotoxic effects, DNA fragmentation and changes of activation of caspase-3, Akt, Erk and p38 were blocked by antioxidant (N-acetylcysteine) and metabolic products of the HMG-CoA reductase reaction, such as mevalonate, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	258-261	caspase 3	Mus musculus	81-90
23479762-6	2013	PAI-1 mRNA and protein expression levels were both increased with high glucose concentrations, but they were significantly suppressed by simvastatin and atorvastatin treatment (P < 0.01) and the effects were reversed by mevalonate (100 mumol/L) and geranylgeranyl pyrophosphate (10 mumol/L) but not farnesyl pyrophosphate (10 mumol/L).	farnesyl pyrophosphate	302-324	serpin family E member 1	Homo sapiens	0-5
22842101-2	2013	A key enzyme in this pathway is farnesyl pyrophosphate (EC 2.5.1.10) synthase (FPPS) which supplies precursors for the biosynthesis of essential isoprenoids like carotenoids, withanolides, ubiquinones, dolichols, sterols, among others and also helps in farnesylation and geranylation of proteins.	farnesyl pyrophosphate	32-54	farnesyl diphosphate synthase	Homo sapiens	79-83
23103563-7	2013	Further we found stimulation of FAS-expression as a result of epigenetic DNA demethylation that was due to down-regulation of DNMT1, which was rescued by re-isoprenylation by both geranylgeranyl-pyrophosphate and farnesylpyrophosphate.	farnesyl pyrophosphate	213-234	DNA methyltransferase (cytosine-5) 1	Mus musculus	126-131
23234314-1	2012	BACKGROUND: Human farnesyl pyrophosphate synthase (FPPS) controls intracellular levels of farnesyl pyrophosphate, which is essential for various biological processes.	farnesyl pyrophosphate	18-40	farnesyl diphosphate synthase	Homo sapiens	51-55
21801306-7	2012	The prenylation agonist farnesyl pyrophosphate (FPP) partially normalized FTI-276 inhibited extracellular MMP-1 levels and invasion capacity while transiently delayed its cellular podia distribution.	farnesyl pyrophosphate	24-46	matrix metallopeptidase 1	Homo sapiens	106-111
23110365-10	2012	It also identifies the particular role of the PDR8 gene in the production of farnesyldiphosphate derivatives, of ABZ1 in the production of numerous compounds and of PLB2 in ethyl ester synthesis.	farnesyl pyrophosphate	77-96	Pdr8p	Saccharomyces cerevisiae S288C	46-50
22883514-6	2012	Kinetic analyses revealed that farnesyl diphosphate was the most favorable for AtHEPS among the allylic substrates tested suggesting that AtHEPS was responsible for the formation of C(35) betulaprenol.	farnesyl pyrophosphate	31-51	Undecaprenyl pyrophosphate synthetase family protein	Arabidopsis thaliana	79-85
22883514-6	2012	Kinetic analyses revealed that farnesyl diphosphate was the most favorable for AtHEPS among the allylic substrates tested suggesting that AtHEPS was responsible for the formation of C(35) betulaprenol.	farnesyl pyrophosphate	31-51	Undecaprenyl pyrophosphate synthetase family protein	Arabidopsis thaliana	138-144
22492974-4	2012	Because statin-induced inhibition of HMGCR reduces the production of substrates for isoprenylation-geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP)-the effects of GGPP and FPP were also evaluated.	farnesyl pyrophosphate	139-161	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	37-42
22492974-4	2012	Because statin-induced inhibition of HMGCR reduces the production of substrates for isoprenylation-geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP)-the effects of GGPP and FPP were also evaluated.	farnesyl pyrophosphate	163-166	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	37-42
22492974-4	2012	Because statin-induced inhibition of HMGCR reduces the production of substrates for isoprenylation-geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP)-the effects of GGPP and FPP were also evaluated.	farnesyl pyrophosphate	192-195	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	37-42
22628078-0	2012	Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y12 receptor-mediated platelet aggregation.	farnesyl pyrophosphate	0-22	purinergic receptor P2Y12	Homo sapiens	69-74
22628078-6	2012	FPP inhibited ADP-induced expression of P-selectin and the activated glycoprotein (Gp)IIb/IIIa receptor.	farnesyl pyrophosphate	0-3	selectin P	Homo sapiens	40-50
22628078-11	2012	In conclusion, FPP is an insurmountable antagonist of ADP-induced platelet aggregation mediated by the P2Y12 receptor.	farnesyl pyrophosphate	15-18	purinergic receptor P2Y12	Homo sapiens	103-108
21801306-7	2012	The prenylation agonist farnesyl pyrophosphate (FPP) partially normalized FTI-276 inhibited extracellular MMP-1 levels and invasion capacity while transiently delayed its cellular podia distribution.	farnesyl pyrophosphate	48-51	matrix metallopeptidase 1	Homo sapiens	106-111
22397618-1	2012	Recombinant (+)-delta-cadinene synthase (DCS) from Gossypium arboreum catalyzes the metal-dependent cyclization of (E,E)-farnesyl diphosphate (FDP) to the cadinane sesquiterpene delta-cadinene, the parent hydrocarbon of cotton phytoalexins such as gossypol.	farnesyl pyrophosphate	115-141	(+)-delta-cadinene synthase	Gossypium hirsutum	12-39
22425978-4	2012	Squalene synthase catalyses dimerization of two farnesyl diphosphate (FPP) molecules into squalene, a key precursor for sterols and triterpenes.	farnesyl pyrophosphate	48-68	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
22425978-4	2012	Squalene synthase catalyses dimerization of two farnesyl diphosphate (FPP) molecules into squalene, a key precursor for sterols and triterpenes.	farnesyl pyrophosphate	70-73	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
21903868-1	2011	Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.	farnesyl pyrophosphate	114-134	farnesyl diphosphate synthase	Homo sapiens	145-149
24527275-7	2012	Further, a key intermediate molecule in the cholesterol synthesis pathway, farnesyl pyrophosphate (FPP), can bind glucocorticoid receptor (GR) and activate GR.	farnesyl pyrophosphate	75-97	nuclear receptor subfamily 3 group C member 1	Homo sapiens	114-137
24527275-7	2012	Further, a key intermediate molecule in the cholesterol synthesis pathway, farnesyl pyrophosphate (FPP), can bind glucocorticoid receptor (GR) and activate GR.	farnesyl pyrophosphate	75-97	nuclear receptor subfamily 3 group C member 1	Homo sapiens	139-141
24527275-7	2012	Further, a key intermediate molecule in the cholesterol synthesis pathway, farnesyl pyrophosphate (FPP), can bind glucocorticoid receptor (GR) and activate GR.	farnesyl pyrophosphate	75-97	nuclear receptor subfamily 3 group C member 1	Homo sapiens	156-158
24527275-7	2012	Further, a key intermediate molecule in the cholesterol synthesis pathway, farnesyl pyrophosphate (FPP), can bind glucocorticoid receptor (GR) and activate GR.	farnesyl pyrophosphate	99-102	nuclear receptor subfamily 3 group C member 1	Homo sapiens	114-137
24527275-7	2012	Further, a key intermediate molecule in the cholesterol synthesis pathway, farnesyl pyrophosphate (FPP), can bind glucocorticoid receptor (GR) and activate GR.	farnesyl pyrophosphate	99-102	nuclear receptor subfamily 3 group C member 1	Homo sapiens	139-141
24527275-7	2012	Further, a key intermediate molecule in the cholesterol synthesis pathway, farnesyl pyrophosphate (FPP), can bind glucocorticoid receptor (GR) and activate GR.	farnesyl pyrophosphate	99-102	nuclear receptor subfamily 3 group C member 1	Homo sapiens	156-158
24527275-12	2012	Topical administration of inhibitors of cortisol synthesis, statins, beta2AR antagonists, and systemic beta-blockers can decrease cortisol synthesis, FPP, and epinephrine levels, respectively, thus restoring keratinocyte migration capacity.	farnesyl pyrophosphate	150-153	adrenoceptor beta 2	Homo sapiens	69-76
21904947-7	2012	We found that in MC3T3-E1 cells, H(2)O(2)-induced upregulation of Nox4 expression was inhibited by simvastatin, which was restored by farnesyl pyrophosphate (5 muM) as well as geranylgeranyl pyrophosphate (5 muM).	farnesyl pyrophosphate	134-156	NADPH oxidase 4	Mus musculus	66-70
22085443-1	2012	Farnesyl diphosphate synthase (FDPS) catalyzes the conversion of isopentenyl diphosphate and dimethylallyl diphosphate to farnesyl diphosphate, a crucial metabolic intermediate in the synthesis of cholesterol, ubiquinone, and prenylated proteins; consequently, much effort has gone into developing inhibitors that target FDPS.	farnesyl pyrophosphate	122-142	farnesyl diphosphate synthase	Homo sapiens	0-29
22085443-1	2012	Farnesyl diphosphate synthase (FDPS) catalyzes the conversion of isopentenyl diphosphate and dimethylallyl diphosphate to farnesyl diphosphate, a crucial metabolic intermediate in the synthesis of cholesterol, ubiquinone, and prenylated proteins; consequently, much effort has gone into developing inhibitors that target FDPS.	farnesyl pyrophosphate	122-142	farnesyl diphosphate synthase	Homo sapiens	31-35
22085443-1	2012	Farnesyl diphosphate synthase (FDPS) catalyzes the conversion of isopentenyl diphosphate and dimethylallyl diphosphate to farnesyl diphosphate, a crucial metabolic intermediate in the synthesis of cholesterol, ubiquinone, and prenylated proteins; consequently, much effort has gone into developing inhibitors that target FDPS.	farnesyl pyrophosphate	122-142	farnesyl diphosphate synthase	Homo sapiens	321-325
21903868-2	2011	Squalene synthase (SQS) utilizes FPP in the first committed step from the mevalonate pathway toward cholesterol biosynthesis.	farnesyl pyrophosphate	33-36	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
21903868-2	2011	Squalene synthase (SQS) utilizes FPP in the first committed step from the mevalonate pathway toward cholesterol biosynthesis.	farnesyl pyrophosphate	33-36	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	19-22
21793802-6	2011	present evidence that the isoprenoid FPP (farnesyl pyrophosphate) may be a bona fide ligand for the master controller of adipocyte differentiation PPARgamma (peroxisome-proliferator-activated receptor gamma).	farnesyl pyrophosphate	42-64	peroxisome proliferator activated receptor gamma	Homo sapiens	147-156
21605082-0	2011	Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARgamma agonist.	farnesyl pyrophosphate	0-22	peroxisome proliferator activated receptor gamma	Homo sapiens	70-79
21605082-4	2011	In the luciferase reporter assay using both GAL4 chimaera and full-length PPARgamma systems, a mevalonate metabolite, FPP (farnesyl pyrophosphate), which is the precursor of almost all isoprenoids and is positioned at branch points leading to the synthesis of other longer-chain isoprenoids, activated PPARgamma in a dose-dependent manner.	farnesyl pyrophosphate	118-121	galectin 4	Homo sapiens	44-48
21605082-4	2011	In the luciferase reporter assay using both GAL4 chimaera and full-length PPARgamma systems, a mevalonate metabolite, FPP (farnesyl pyrophosphate), which is the precursor of almost all isoprenoids and is positioned at branch points leading to the synthesis of other longer-chain isoprenoids, activated PPARgamma in a dose-dependent manner.	farnesyl pyrophosphate	118-121	peroxisome proliferator activated receptor gamma	Homo sapiens	74-83
21605082-4	2011	In the luciferase reporter assay using both GAL4 chimaera and full-length PPARgamma systems, a mevalonate metabolite, FPP (farnesyl pyrophosphate), which is the precursor of almost all isoprenoids and is positioned at branch points leading to the synthesis of other longer-chain isoprenoids, activated PPARgamma in a dose-dependent manner.	farnesyl pyrophosphate	118-121	peroxisome proliferator activated receptor gamma	Homo sapiens	302-311
21605082-4	2011	In the luciferase reporter assay using both GAL4 chimaera and full-length PPARgamma systems, a mevalonate metabolite, FPP (farnesyl pyrophosphate), which is the precursor of almost all isoprenoids and is positioned at branch points leading to the synthesis of other longer-chain isoprenoids, activated PPARgamma in a dose-dependent manner.	farnesyl pyrophosphate	123-145	galectin 4	Homo sapiens	44-48
21605082-4	2011	In the luciferase reporter assay using both GAL4 chimaera and full-length PPARgamma systems, a mevalonate metabolite, FPP (farnesyl pyrophosphate), which is the precursor of almost all isoprenoids and is positioned at branch points leading to the synthesis of other longer-chain isoprenoids, activated PPARgamma in a dose-dependent manner.	farnesyl pyrophosphate	123-145	peroxisome proliferator activated receptor gamma	Homo sapiens	74-83
21605082-4	2011	In the luciferase reporter assay using both GAL4 chimaera and full-length PPARgamma systems, a mevalonate metabolite, FPP (farnesyl pyrophosphate), which is the precursor of almost all isoprenoids and is positioned at branch points leading to the synthesis of other longer-chain isoprenoids, activated PPARgamma in a dose-dependent manner.	farnesyl pyrophosphate	123-145	peroxisome proliferator activated receptor gamma	Homo sapiens	302-311
21605082-5	2011	FPP induced the in vitro binding of a co-activator, SRC-1 (steroid receptor co-activator-1), to GST (glutathione transferase)-PPARgamma.	farnesyl pyrophosphate	0-3	nuclear receptor coactivator 1	Homo sapiens	52-57
21605082-5	2011	FPP induced the in vitro binding of a co-activator, SRC-1 (steroid receptor co-activator-1), to GST (glutathione transferase)-PPARgamma.	farnesyl pyrophosphate	0-3	nuclear receptor coactivator 1	Homo sapiens	59-90
21605082-5	2011	FPP induced the in vitro binding of a co-activator, SRC-1 (steroid receptor co-activator-1), to GST (glutathione transferase)-PPARgamma.	farnesyl pyrophosphate	0-3	peroxisome proliferator activated receptor gamma	Homo sapiens	126-135
21605082-8	2011	In the presence of lovastatin, an HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitor, both intracellular FPP levels and PPARgamma-target gene expressions were decreased.	farnesyl pyrophosphate	115-118	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	43-84
21605082-9	2011	In contrast, the increase in intracellular FPP level after the addition of zaragozic acid, a squalene synthase inhibitor, induced PPARgamma-target gene expression.	farnesyl pyrophosphate	43-46	peroxisome proliferator activated receptor gamma	Homo sapiens	130-139
21793802-6	2011	present evidence that the isoprenoid FPP (farnesyl pyrophosphate) may be a bona fide ligand for the master controller of adipocyte differentiation PPARgamma (peroxisome-proliferator-activated receptor gamma).	farnesyl pyrophosphate	42-64	peroxisome proliferator activated receptor gamma	Homo sapiens	158-206
21503955-7	2011	By inhibiting GGPPS, DGBP caused an accumulation of the GGPPS substrate farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	72-94	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	14-19
21586555-2	2011	Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	178-200	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	16-69
21586555-2	2011	Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	178-200	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	71-76
21586555-2	2011	Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	202-205	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	16-69
21586555-2	2011	Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).	farnesyl pyrophosphate	202-205	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	71-76
21586555-9	2011	Simultaneous HMGCR inhibition prevented the accumulation of FPP and restored osteoblast differentiation.	farnesyl pyrophosphate	60-63	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	13-18
21503955-7	2011	By inhibiting GGPPS, DGBP caused an accumulation of the GGPPS substrate farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	72-94	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	56-61
21503955-7	2011	By inhibiting GGPPS, DGBP caused an accumulation of the GGPPS substrate farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	96-99	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	14-19
21503955-7	2011	By inhibiting GGPPS, DGBP caused an accumulation of the GGPPS substrate farnesyl pyrophosphate (FPP).	farnesyl pyrophosphate	96-99	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	56-61
21572394-2	2011	Dol-P is synthesized by the successive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isoprenyltransferase (cis-IPTase) activity.	farnesyl pyrophosphate	91-111	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	127-151
21572394-2	2011	Dol-P is synthesized by the successive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isoprenyltransferase (cis-IPTase) activity.	farnesyl pyrophosphate	91-111	dehydrodolichyl diphosphate synthase subunit	Homo sapiens	153-163
20450493-1	2010	FDPS (farnesyl diphosphate synthase) catalyses the formation of farnesyl diphosphate, a key intermediate in the synthesis of cholesterol and isoprenylated cellular metabolites.	farnesyl pyrophosphate	6-26	farnesyl diphosphate synthase	Homo sapiens	0-4
20923173-8	2010	In the first binding motif, WT1, the Mg2+ ion is coordinated to D352beta, zinc-bound D297beta, two water molecules, and one oxygen atom from the alpha- and beta-phosphates of farnesyl diphosphate (FPP).	farnesyl pyrophosphate	175-195	WT1 transcription factor	Homo sapiens	28-31
20923173-8	2010	In the first binding motif, WT1, the Mg2+ ion is coordinated to D352beta, zinc-bound D297beta, two water molecules, and one oxygen atom from the alpha- and beta-phosphates of farnesyl diphosphate (FPP).	farnesyl pyrophosphate	197-200	WT1 transcription factor	Homo sapiens	28-31
20923173-12	2010	In all Mg2+ binding motifs, a key hydrogen bond was identified between a magnesium-bound water and Cys1p, bridging the two metallic binding sites and, thereby, reducing the equilibrium distance between the reacting atoms of FPP Cys1p.	farnesyl pyrophosphate	224-227	cystin 1	Homo sapiens	99-104
20923173-12	2010	In all Mg2+ binding motifs, a key hydrogen bond was identified between a magnesium-bound water and Cys1p, bridging the two metallic binding sites and, thereby, reducing the equilibrium distance between the reacting atoms of FPP Cys1p.	farnesyl pyrophosphate	224-227	cystin 1	Homo sapiens	228-233
20560544-13	2010	CrtM catalyzes the first committed step in biosynthesis of the carotenoid virulence factor staphyloxanthin: the condensation of two FPP molecules to produce a cyclopropane (presqualene diphosphate).	farnesyl pyrophosphate	132-135	matrilin 1	Homo sapiens	0-4
21353389-3	2011	Recently, we reported that farnesyl pyrophosphate, an endogenous substance produced in the mevalonate pathway, is a specific activator for TRPV3.	farnesyl pyrophosphate	27-49	transient receptor potential cation channel subfamily V member 3	Homo sapiens	139-144
20405344-4	2010	In the present study, it was determined if cellular levels of FPP, GGPP, and cholesterol affect beta-amyloid (Abeta) abundance in SH-SY5Y cells, expressing human APP695.	farnesyl pyrophosphate	62-65	amyloid beta precursor protein	Homo sapiens	110-115
20395302-0	2010	Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.	farnesyl pyrophosphate	0-22	transient receptor potential cation channel subfamily V member 3	Homo sapiens	85-90
20395302-3	2010	Here, we show that farnesyl pyrophosphate (FPP), an intermediate metabolite in the mevalonate pathway, specifically activates TRPV3 among six thermoTRPs using Ca(2+) imaging and electrophysiology with cultured keratinocytes and TRPV3-overexpressing cells.	farnesyl pyrophosphate	19-41	transient receptor potential cation channel subfamily V member 3	Homo sapiens	126-131
20395302-3	2010	Here, we show that farnesyl pyrophosphate (FPP), an intermediate metabolite in the mevalonate pathway, specifically activates TRPV3 among six thermoTRPs using Ca(2+) imaging and electrophysiology with cultured keratinocytes and TRPV3-overexpressing cells.	farnesyl pyrophosphate	19-41	transient receptor potential cation channel subfamily V member 3	Homo sapiens	228-233
20395302-3	2010	Here, we show that farnesyl pyrophosphate (FPP), an intermediate metabolite in the mevalonate pathway, specifically activates TRPV3 among six thermoTRPs using Ca(2+) imaging and electrophysiology with cultured keratinocytes and TRPV3-overexpressing cells.	farnesyl pyrophosphate	43-46	transient receptor potential cation channel subfamily V member 3	Homo sapiens	126-131
20395302-3	2010	Here, we show that farnesyl pyrophosphate (FPP), an intermediate metabolite in the mevalonate pathway, specifically activates TRPV3 among six thermoTRPs using Ca(2+) imaging and electrophysiology with cultured keratinocytes and TRPV3-overexpressing cells.	farnesyl pyrophosphate	43-46	transient receptor potential cation channel subfamily V member 3	Homo sapiens	228-233
20395302-5	2010	Voltage-dependence of TRPV3 was shifted by FPP, which appears to be the activation mechanism.	farnesyl pyrophosphate	43-46	transient receptor potential cation channel subfamily V member 3	Homo sapiens	22-27
20395302-6	2010	An intraplantar injection of FPP acutely elicits nociceptive behaviors in inflamed animals, indicating that FPP is a novel endogenous pain-producing substance via TRPV3 activation.	farnesyl pyrophosphate	29-32	transient receptor potential cation channel subfamily V member 3	Homo sapiens	163-168
20395302-6	2010	An intraplantar injection of FPP acutely elicits nociceptive behaviors in inflamed animals, indicating that FPP is a novel endogenous pain-producing substance via TRPV3 activation.	farnesyl pyrophosphate	108-111	transient receptor potential cation channel subfamily V member 3	Homo sapiens	163-168
20395302-9	2010	Taken together, our data suggest that FPP is the firstly identified endogenous TRPV3 activator that causes nociception.	farnesyl pyrophosphate	38-41	transient receptor potential cation channel subfamily V member 3	Homo sapiens	79-84
20110354-3	2010	In vitro, recombinant PDP1/PPAPDC2 preferentially hydrolyzed polyisoprenoid diphosphates, including FPP and GGPP over a variety of glycerol- and sphingo-phospholipid substrates.	farnesyl pyrophosphate	100-103	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	22-26
20110354-3	2010	In vitro, recombinant PDP1/PPAPDC2 preferentially hydrolyzed polyisoprenoid diphosphates, including FPP and GGPP over a variety of glycerol- and sphingo-phospholipid substrates.	farnesyl pyrophosphate	100-103	phospholipid phosphatase 6	Homo sapiens	27-34
19379823-4	2009	Here, we give a brief history of these orphan lipids and highlight the activity of N-arachidonoyl glycine, and farnesyl pyrophosphate at the orphan receptors GPR18 and GPR92, respectively, as well as summarizing the biological and pharmacological data for the recently identified N-palmitoyl glycine that suggests activity at a novel GPCR.	farnesyl pyrophosphate	111-133	G protein-coupled receptor 18	Homo sapiens	158-163
19903814-0	2010	Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor.	farnesyl pyrophosphate	0-22	nuclear receptor subfamily 3 group C member 1	Homo sapiens	80-103
19903814-2	2010	Here we show a novel mechanism by which FPP inhibits wound healing acting as an agonist for glucocorticoid receptor (GR).	farnesyl pyrophosphate	40-43	nuclear receptor subfamily 3 group C member 1	Homo sapiens	92-115
19903814-2	2010	Here we show a novel mechanism by which FPP inhibits wound healing acting as an agonist for glucocorticoid receptor (GR).	farnesyl pyrophosphate	40-43	nuclear receptor subfamily 3 group C member 1	Homo sapiens	117-119
19903814-3	2010	Elevation of endogenous FPP by the squalene synthetase inhibitor zaragozic acid A (ZGA) or addition of FPP to the cell culture medium results in activation and nuclear translocation of the GR, a known wound healing inhibitor.	farnesyl pyrophosphate	24-27	nuclear receptor subfamily 3 group C member 1	Homo sapiens	189-191
19903814-8	2010	Furthermore, we show that the 3-hydroxy-3-methylglutaryl-CoA-reductase inhibitor mevastatin, which blocks FPP formation, not only promotes epithelialization in acute wounds but also reverses the effect of ZGA on activation of the GR and inhibition of epithelialization.	farnesyl pyrophosphate	106-109	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	30-70
19903814-9	2010	We conclude that FPP inhibits wound healing by acting as a GR agonist.	farnesyl pyrophosphate	17-20	nuclear receptor subfamily 3 group C member 1	Homo sapiens	59-61
20298756-3	2010	Farnesyl diphosphate, a catalytic product of FPPS, also attenuated mentioned paclitaxel-induced apoptotic cell death.	farnesyl pyrophosphate	0-20	farnesyl diphosphate synthase	Homo sapiens	45-49
19776008-3	2009	We had previously shown that alterations in cellular levels of the 15-carbon sterol pathway intermediate farnesyl pyrophosphate (FPP) cause increased Hmg2p ubiquitination and degradation.	farnesyl pyrophosphate	105-127	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	150-155
19776008-3	2009	We had previously shown that alterations in cellular levels of the 15-carbon sterol pathway intermediate farnesyl pyrophosphate (FPP) cause increased Hmg2p ubiquitination and degradation.	farnesyl pyrophosphate	129-132	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	150-155
19776008-4	2009	We now present evidence that the FPP-derived, 20-carbon molecule geranylgeranyl pyrophosphate (GGPP) is a potent endogenous regulator of Hmg2p degradation.	farnesyl pyrophosphate	33-36	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	137-142
19633972-3	2009	The reactions leading to the production of geranyl diphosphate (C10), farnesyl diphosphate (C15) and geranylgeranyl diphosphate (C20), which are the precursors of mono-, sesqui- and diterpenes, respectively, are catalyzed by a group of highly conserved enzymes known as short-chain isoprenyl diphosphate synthases, or prenyltransferases.	farnesyl pyrophosphate	70-90	placenta associated 8	Homo sapiens	92-95
19801484-4	2009	Overexpression of geranylgeranyl pyrophosphate (GGPP) synthase from S. cerevisiae (the BTS1 gene product) increased the intracellular beta-carotene levels due to the accelerated conversion of farnesyl pyrophosphate to GGPP.	farnesyl pyrophosphate	192-214	farnesyltranstransferase	Saccharomyces cerevisiae S288C	87-91
19379823-4	2009	Here, we give a brief history of these orphan lipids and highlight the activity of N-arachidonoyl glycine, and farnesyl pyrophosphate at the orphan receptors GPR18 and GPR92, respectively, as well as summarizing the biological and pharmacological data for the recently identified N-palmitoyl glycine that suggests activity at a novel GPCR.	farnesyl pyrophosphate	111-133	lysophosphatidic acid receptor 5	Homo sapiens	168-173
19456099-2	2009	Here, we report the synthesis and activity of a broad variety of staphyloxanthin biosynthesis inhibitors that inhibit the first committed step in its biosynthesis, condensation of two farnesyl diphosphate (FPP) molecules to dehydrosqualene, catalyzed by the enzyme dehydrosqualene synthase (CrtM).	farnesyl pyrophosphate	206-209	matrilin 1, cartilage matrix protein	Mus musculus	291-295
19309001-1	2009	Farnesyl diphosphate synthase (FPPS) catalyzes the consecutive condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate to form farnesyl diphosphate (FPP).	farnesyl pyrophosphate	159-179	farnesyl pyrophosphate synthase 1-like	Gossypium hirsutum	31-35
19360310-6	2009	Simvastatin and lovastatin significantly inhibited H-Ras-induced invasion which was reversed by farnesyl pyrophosphate (FPP), indicating that the inhibitory effect was related to inhibition of the biosynthesis of prenylated derivatives.	farnesyl pyrophosphate	96-118	HRas proto-oncogene, GTPase	Homo sapiens	51-56
19358180-10	2009	The inhibitory effect of simvastatin on PAI-1 activation was reversed by GGPP and FPP.	farnesyl pyrophosphate	82-85	serpin family E member 1	Homo sapiens	40-45
19416104-2	2009	FPP formed from mevalonate in a reaction catalyzed by FPP synthase (Erg20p).	farnesyl pyrophosphate	0-3	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	68-74
19416104-5	2009	Deletion of YTA7 affected the enzymatic activity of cis-prenyltransferase (the enzyme that utilizes FPP for dolichol biosynthesis) and the cellular levels of isoprenoid compounds.	farnesyl pyrophosphate	100-103	Yta7p	Saccharomyces cerevisiae S288C	12-16
19286662-6	2009	GPR92 was confirmed to be a lysophosphatidic acid receptor with weaker responses to farnesyl pyrophosphate and geranylgeranyl diphosphate.	farnesyl pyrophosphate	84-106	lysophosphatidic acid receptor 5	Mus musculus	0-5
19360310-6	2009	Simvastatin and lovastatin significantly inhibited H-Ras-induced invasion which was reversed by farnesyl pyrophosphate (FPP), indicating that the inhibitory effect was related to inhibition of the biosynthesis of prenylated derivatives.	farnesyl pyrophosphate	120-123	HRas proto-oncogene, GTPase	Homo sapiens	51-56
18692592-8	2009	Endothelial cells exposed to high glucose increased their secretion of TGFbeta(1) and the phosphorylation of p38 both of which were reversed by concurrent exposure to FPP.	farnesyl pyrophosphate	167-170	transforming growth factor, beta 1	Rattus norvegicus	71-81
19352075-4	2009	RhoB can be isoprenylated by either geranylgeranylpyrophosphate (GGPP) or farnesylpyrophosphate (FPP).	farnesyl pyrophosphate	74-95	ras homolog family member B	Rattus norvegicus	0-4
19352075-4	2009	RhoB can be isoprenylated by either geranylgeranylpyrophosphate (GGPP) or farnesylpyrophosphate (FPP).	farnesyl pyrophosphate	97-100	ras homolog family member B	Rattus norvegicus	0-4
18692592-8	2009	Endothelial cells exposed to high glucose increased their secretion of TGFbeta(1) and the phosphorylation of p38 both of which were reversed by concurrent exposure to FPP.	farnesyl pyrophosphate	167-170	mitogen activated protein kinase 14	Rattus norvegicus	109-112
19151033-12	2009	Treatment with L-mevalonate or farnesylpyrophosphate, but not geranylgeranyl-pyrophosphate reversed the statin-induced effect on CRP-mediated functions and ERK 1/2 phosphorylation, confirming that statins blocked CRP-induced ERK 1/2 phosphorylation through the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.	farnesyl pyrophosphate	31-52	C-reactive protein	Homo sapiens	129-132
19151033-12	2009	Treatment with L-mevalonate or farnesylpyrophosphate, but not geranylgeranyl-pyrophosphate reversed the statin-induced effect on CRP-mediated functions and ERK 1/2 phosphorylation, confirming that statins blocked CRP-induced ERK 1/2 phosphorylation through the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.	farnesyl pyrophosphate	31-52	mitogen-activated protein kinase 3	Homo sapiens	156-163
19151033-12	2009	Treatment with L-mevalonate or farnesylpyrophosphate, but not geranylgeranyl-pyrophosphate reversed the statin-induced effect on CRP-mediated functions and ERK 1/2 phosphorylation, confirming that statins blocked CRP-induced ERK 1/2 phosphorylation through the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.	farnesyl pyrophosphate	31-52	C-reactive protein	Homo sapiens	213-216
19151033-12	2009	Treatment with L-mevalonate or farnesylpyrophosphate, but not geranylgeranyl-pyrophosphate reversed the statin-induced effect on CRP-mediated functions and ERK 1/2 phosphorylation, confirming that statins blocked CRP-induced ERK 1/2 phosphorylation through the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.	farnesyl pyrophosphate	31-52	mitogen-activated protein kinase 3	Homo sapiens	225-232
19151033-12	2009	Treatment with L-mevalonate or farnesylpyrophosphate, but not geranylgeranyl-pyrophosphate reversed the statin-induced effect on CRP-mediated functions and ERK 1/2 phosphorylation, confirming that statins blocked CRP-induced ERK 1/2 phosphorylation through the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.	farnesyl pyrophosphate	31-52	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	275-332
18499677-0	2008	Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.	farnesyl pyrophosphate	18-40	lysophosphatidic acid receptor 5	Homo sapiens	92-97
18499677-2	2008	Lipid-derived molecules including farnesyl pyrophosphate (FPP), N-arachidonylglycine (NAG), and lysophosphatidic acid were found to activate GPR92.	farnesyl pyrophosphate	34-56	lysophosphatidic acid receptor 5	Homo sapiens	141-146
18499677-2	2008	Lipid-derived molecules including farnesyl pyrophosphate (FPP), N-arachidonylglycine (NAG), and lysophosphatidic acid were found to activate GPR92.	farnesyl pyrophosphate	58-61	lysophosphatidic acid receptor 5	Homo sapiens	141-146
18499677-4	2008	Computer-simulated modeling combined with site-directed mutagenesis of GPR92 indicated that Thr(97), Gly(98), Phe(101), and Arg(267) of GPR92 are responsible for the interaction of GPR92 with FPP and NAG.	farnesyl pyrophosphate	192-195	lysophosphatidic acid receptor 5	Homo sapiens	71-76
18499677-4	2008	Computer-simulated modeling combined with site-directed mutagenesis of GPR92 indicated that Thr(97), Gly(98), Phe(101), and Arg(267) of GPR92 are responsible for the interaction of GPR92 with FPP and NAG.	farnesyl pyrophosphate	192-195	lysophosphatidic acid receptor 5	Homo sapiens	136-141
18499677-4	2008	Computer-simulated modeling combined with site-directed mutagenesis of GPR92 indicated that Thr(97), Gly(98), Phe(101), and Arg(267) of GPR92 are responsible for the interaction of GPR92 with FPP and NAG.	farnesyl pyrophosphate	192-195	lysophosphatidic acid receptor 5	Homo sapiens	136-141
18499677-9	2008	These results suggest that FPP and NAG play a role in the sensory nervous system through activation of GPR92.	farnesyl pyrophosphate	27-30	lysophosphatidic acid receptor 5	Homo sapiens	103-108