PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33995637-0	2021	Cardamonin inhibits the progression of oesophageal cancer by inhibiting the PI3K/AKT signalling pathway.	cardamonin	0-10	AKT serine/threonine kinase 1	Homo sapiens	81-84
34024891-0	2021	Cardamonin Inhibited IL-1beta-induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO1 Signaling Pathway in Chondrocyte.	cardamonin	0-10	interleukin 1 alpha	Homo sapiens	21-29
34024891-0	2021	Cardamonin Inhibited IL-1beta-induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO1 Signaling Pathway in Chondrocyte.	cardamonin	0-10	NLR family pyrin domain containing 3	Homo sapiens	62-67
34024891-0	2021	Cardamonin Inhibited IL-1beta-induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO1 Signaling Pathway in Chondrocyte.	cardamonin	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
34024891-0	2021	Cardamonin Inhibited IL-1beta-induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO1 Signaling Pathway in Chondrocyte.	cardamonin	0-10	NAD(P)H quinone dehydrogenase 1	Homo sapiens	101-105
34024891-7	2021	Cardamonin reversed the effect of IL-1beta on cell viability, cell apoptosis, pro-inflammatory cytokines, MMPs, Collage II, NLRP3 inflammasome levels.	cardamonin	0-10	interleukin 1 alpha	Homo sapiens	34-42
34024891-7	2021	Cardamonin reversed the effect of IL-1beta on cell viability, cell apoptosis, pro-inflammatory cytokines, MMPs, Collage II, NLRP3 inflammasome levels.	cardamonin	0-10	NLR family pyrin domain containing 3	Homo sapiens	124-129
34024891-10	2021	Cardamonin inhibited IL-1beta-induced injury by inhibition of NLRP3 inflammasome via activating Nrf2/NQO1 signaling pathway in chondrocyte.	cardamonin	0-10	interleukin 1 alpha	Homo sapiens	21-29
34024891-10	2021	Cardamonin inhibited IL-1beta-induced injury by inhibition of NLRP3 inflammasome via activating Nrf2/NQO1 signaling pathway in chondrocyte.	cardamonin	0-10	NLR family pyrin domain containing 3	Homo sapiens	62-67
34024891-10	2021	Cardamonin inhibited IL-1beta-induced injury by inhibition of NLRP3 inflammasome via activating Nrf2/NQO1 signaling pathway in chondrocyte.	cardamonin	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
34024891-10	2021	Cardamonin inhibited IL-1beta-induced injury by inhibition of NLRP3 inflammasome via activating Nrf2/NQO1 signaling pathway in chondrocyte.	cardamonin	0-10	NAD(P)H quinone dehydrogenase 1	Homo sapiens	101-105
33448051-5	2021	In addition, cardamonin, a beta-catenin inhibitor, was used to determine the signaling pathway for beta-catenin in which cardamonin inhibited the AGEs-induced translocation of beta-catenin into the nucleus, resulting in an inhibition of the EMT process.	cardamonin	121-131	catenin beta 1	Homo sapiens	99-111
33043385-0	2021	Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor.	cardamonin	0-10	caspase 1	Homo sapiens	42-49
33043385-0	2021	Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor.	cardamonin	0-10	regulatory associated protein of MTOR complex 1	Homo sapiens	71-77
33043385-2	2021	We investigated the mechanism that cardamonin decreases Raptor expression through caspase-mediated protein degradation.	cardamonin	35-45	regulatory associated protein of MTOR complex 1	Homo sapiens	56-62
33043385-2	2021	We investigated the mechanism that cardamonin decreases Raptor expression through caspase-mediated protein degradation.	cardamonin	35-45	caspase 1	Homo sapiens	82-89
32317756-0	2021	Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism.	cardamonin	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
33947113-3	2021	In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-alpha, and IL-6, and inhibited NF-kB signaling which emphasizes the role of cardamonin as an anti-inflammatory molecule.	cardamonin	35-45	nitric oxide synthase 2, inducible	Mus musculus	157-161
33947113-3	2021	In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-alpha, and IL-6, and inhibited NF-kB signaling which emphasizes the role of cardamonin as an anti-inflammatory molecule.	cardamonin	35-45	tumor necrosis factor	Mus musculus	163-172
33947113-3	2021	In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-alpha, and IL-6, and inhibited NF-kB signaling which emphasizes the role of cardamonin as an anti-inflammatory molecule.	cardamonin	35-45	interleukin 6	Mus musculus	178-182
33370628-0	2021	Cardamonin inhibits the growth of human osteosarcoma cells through activating P38 and JNK signaling pathway.	cardamonin	0-10	mitogen-activated protein kinase 14	Homo sapiens	78-81
33370628-0	2021	Cardamonin inhibits the growth of human osteosarcoma cells through activating P38 and JNK signaling pathway.	cardamonin	0-10	mitogen-activated protein kinase 8	Homo sapiens	86-89
33448051-5	2021	In addition, cardamonin, a beta-catenin inhibitor, was used to determine the signaling pathway for beta-catenin in which cardamonin inhibited the AGEs-induced translocation of beta-catenin into the nucleus, resulting in an inhibition of the EMT process.	cardamonin	121-131	catenin beta 1	Homo sapiens	99-111
33364966-0	2020	Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.	cardamonin	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-103
33316979-6	2020	Additionally, immunofluorescence analysis showed a significant downregulation in anti-apoptotic Bcl-2 protein, whereas pre-apoptotic Bax protein was significantly upregulated in nude mice treated with 25 and 50 mg/kg CADMN as compared to untreated mice.	cardamonin	217-222	B cell leukemia/lymphoma 2	Mus musculus	96-101
33354512-0	2020	Erratum: Author correction to "Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome" [Acta Pharmaceutica Sinica B 9 (2019) 734-744].	cardamonin	31-41	NLR family pyrin domain containing 3	Homo sapiens	121-126
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	cardamonin	13-15	high mobility group box 1	Mus musculus	76-101
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	cardamonin	13-15	high mobility group box 1	Mus musculus	103-108
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	cardamonin	13-15	toll-like receptor 4	Mus musculus	111-131
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	cardamonin	13-15	toll-like receptor 4	Mus musculus	133-137
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	cardamonin	13-15	NLR family, pyrin domain containing 3	Mus musculus	144-171
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	cardamonin	13-15	NLR family, pyrin domain containing 3	Mus musculus	173-178
33364966-8	2020	In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy.	cardamonin	13-15	nucleoporin 62	Mus musculus	54-57
33364966-8	2020	In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy.	cardamonin	13-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-69
33364966-10	2020	), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2-/- mice.	cardamonin	107-109	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-55
33364966-10	2020	), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2-/- mice.	cardamonin	107-109	nuclear factor, erythroid derived 2, like 2	Mus musculus	215-221
33364966-10	2020	), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2-/- mice.	cardamonin	175-177	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-55
33364966-10	2020	), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2-/- mice.	cardamonin	175-177	nuclear factor, erythroid derived 2, like 2	Mus musculus	215-221
33364966-11	2020	Overall, data suggest that CD has hepatoprotective effect against APAP-induced ALI, which might contribute to the activation of NFE2L2 and autophagy.	cardamonin	27-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-134
32706448-8	2020	Our study showed that autophagy induced by cardamonin was associated with mTOR inhibition, and DAP1 was involved in this process.	cardamonin	43-53	mechanistic target of rapamycin kinase	Homo sapiens	74-78
32706448-12	2020	Taken together, our results implied that DAP1 negatively regulates autophagy induced by cardamonin, and it may be a potential target for ovarian cancer therapy.	cardamonin	88-98	death associated protein	Homo sapiens	41-45
32946945-0	2020	Inhibitory functions of cardamonin against particulate matter-induced lung injury through TLR2,4-mTOR-autophagy pathways.	cardamonin	24-34	toll like receptor 2	Homo sapiens	90-96
32946945-0	2020	Inhibitory functions of cardamonin against particulate matter-induced lung injury through TLR2,4-mTOR-autophagy pathways.	cardamonin	24-34	mechanistic target of rapamycin kinase	Homo sapiens	97-101
32946945-6	2020	Cardamonin also significantly inhibited PM2.5-induced myeloperoxidase (MPO) activity in lung tissue, decreased the levels of PM2.5-induced inflammatory cytokines and effectively attenuated PM2.5-induced increases in the number of lymphocytes in the bronchoalveolar lavage fluid (BALF).	cardamonin	0-10	myeloperoxidase	Homo sapiens	54-69
32946945-6	2020	Cardamonin also significantly inhibited PM2.5-induced myeloperoxidase (MPO) activity in lung tissue, decreased the levels of PM2.5-induced inflammatory cytokines and effectively attenuated PM2.5-induced increases in the number of lymphocytes in the bronchoalveolar lavage fluid (BALF).	cardamonin	0-10	myeloperoxidase	Homo sapiens	71-74
32946945-7	2020	And, cardamonin increased the phosphorylation of mammalian target of rapamycin (mTOR) and dramatically suppressed the PM2.5-stimulated expression of toll-like receptor 2 and 4 (TLR 2,4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1.	cardamonin	5-15	mechanistic target of rapamycin kinase	Homo sapiens	49-78
32946945-7	2020	And, cardamonin increased the phosphorylation of mammalian target of rapamycin (mTOR) and dramatically suppressed the PM2.5-stimulated expression of toll-like receptor 2 and 4 (TLR 2,4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1.	cardamonin	5-15	mechanistic target of rapamycin kinase	Homo sapiens	80-84
32946945-7	2020	And, cardamonin increased the phosphorylation of mammalian target of rapamycin (mTOR) and dramatically suppressed the PM2.5-stimulated expression of toll-like receptor 2 and 4 (TLR 2,4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1.	cardamonin	5-15	toll like receptor 2	Homo sapiens	149-175
32946945-7	2020	And, cardamonin increased the phosphorylation of mammalian target of rapamycin (mTOR) and dramatically suppressed the PM2.5-stimulated expression of toll-like receptor 2 and 4 (TLR 2,4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1.	cardamonin	5-15	toll like receptor 2	Homo sapiens	177-184
32946945-7	2020	And, cardamonin increased the phosphorylation of mammalian target of rapamycin (mTOR) and dramatically suppressed the PM2.5-stimulated expression of toll-like receptor 2 and 4 (TLR 2,4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1.	cardamonin	5-15	MYD88 innate immune signal transduction adaptor	Homo sapiens	187-192
32946945-7	2020	And, cardamonin increased the phosphorylation of mammalian target of rapamycin (mTOR) and dramatically suppressed the PM2.5-stimulated expression of toll-like receptor 2 and 4 (TLR 2,4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1.	cardamonin	5-15	beclin 1	Homo sapiens	240-248
32946945-8	2020	In conclusion, these findings indicate that cardamonin has a critical anti-inflammatory effect due to its ability to regulate both the TLR2,4-MyD88 and mTOR-autophagy pathways and may thus be a potential therapeutic agent against PM2.5-induced lung injury.	cardamonin	44-54	toll like receptor 2	Homo sapiens	135-141
32946945-8	2020	In conclusion, these findings indicate that cardamonin has a critical anti-inflammatory effect due to its ability to regulate both the TLR2,4-MyD88 and mTOR-autophagy pathways and may thus be a potential therapeutic agent against PM2.5-induced lung injury.	cardamonin	44-54	MYD88 innate immune signal transduction adaptor	Homo sapiens	142-147
32946945-8	2020	In conclusion, these findings indicate that cardamonin has a critical anti-inflammatory effect due to its ability to regulate both the TLR2,4-MyD88 and mTOR-autophagy pathways and may thus be a potential therapeutic agent against PM2.5-induced lung injury.	cardamonin	44-54	mechanistic target of rapamycin kinase	Homo sapiens	152-156
31918264-7	2020	Additionally, DOX-induced apoptosis and inflammatory response in cardiomyocytes were diminished by CAR through reducing the Caspase-3 and nuclear factor-kappaB (NF-kappaB) signaling pathways, respectively.	cardamonin	99-102	caspase 3	Mus musculus	124-159
32906636-0	2020	Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production.	cardamonin	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
32906636-7	2020	In addition, we found that the production of Th2 cytokines is negatively regulated by NRF2, and the induction of NRF2 by cardamonin contributed to suppressing oxazolone-induced Th2 cytokine production and oxidative damages in vivo.	cardamonin	121-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	113-117
31894316-11	2020	Cardamonin inhibited cell proliferation and decreased the phosphorylation of mTOR and S6K1, as well as the protein level of raptor, in the mTOR inhibitor-resistant cells.	cardamonin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	77-81
31894316-11	2020	Cardamonin inhibited cell proliferation and decreased the phosphorylation of mTOR and S6K1, as well as the protein level of raptor, in the mTOR inhibitor-resistant cells.	cardamonin	0-10	ribosomal protein S6 kinase B1	Homo sapiens	86-90
31894316-11	2020	Cardamonin inhibited cell proliferation and decreased the phosphorylation of mTOR and S6K1, as well as the protein level of raptor, in the mTOR inhibitor-resistant cells.	cardamonin	0-10	regulatory associated protein of MTOR complex 1	Homo sapiens	124-130
31894316-11	2020	Cardamonin inhibited cell proliferation and decreased the phosphorylation of mTOR and S6K1, as well as the protein level of raptor, in the mTOR inhibitor-resistant cells.	cardamonin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	139-143
31894316-12	2020	Therefore, cardamonin may serve as a therapeutic agent for patients with cervical and breast cancer resistant to mTOR inhibitors.	cardamonin	11-21	mechanistic target of rapamycin kinase	Homo sapiens	113-117
33008901-7	2020	Transcriptomic analysis and genetic studies implicated Nrf2/SKN-1 signaling in stress resistance provided by two protective compounds, cardamonin and AEG 3482.	cardamonin	135-145	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
31102118-0	2020	Cardamonin, a natural chalcone, reduces 5-fluorouracil resistance of gastric cancer cells through targeting Wnt/beta-catenin signal pathway.	cardamonin	0-10	catenin beta 1	Homo sapiens	112-124
31894316-0	2020	Anti-proliferative effect of cardamonin on mTOR inhibitor-resistant cancer cells.	cardamonin	29-39	mechanistic target of rapamycin kinase	Homo sapiens	43-47
31894316-4	2020	Cardamonin inhibits mTOR by decreasing the expression of regulatory-associated protein of mTOR (Raptor), a mechanism of action which differs from the currently available mTOR inhibitors.	cardamonin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	20-24
31894316-4	2020	Cardamonin inhibits mTOR by decreasing the expression of regulatory-associated protein of mTOR (Raptor), a mechanism of action which differs from the currently available mTOR inhibitors.	cardamonin	0-10	regulatory associated protein of MTOR complex 1	Homo sapiens	57-94
31894316-4	2020	Cardamonin inhibits mTOR by decreasing the expression of regulatory-associated protein of mTOR (Raptor), a mechanism of action which differs from the currently available mTOR inhibitors.	cardamonin	0-10	regulatory associated protein of MTOR complex 1	Homo sapiens	96-102
31894316-4	2020	Cardamonin inhibits mTOR by decreasing the expression of regulatory-associated protein of mTOR (Raptor), a mechanism of action which differs from the currently available mTOR inhibitors.	cardamonin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	90-94
31894316-5	2020	The present study investigated the inhibitory effects of cardamonin on mTOR inhibitor-resistant cancer cells.	cardamonin	57-67	mechanistic target of rapamycin kinase	Homo sapiens	71-75
31894316-8	2020	The inhibitory effect of cardamonin on mTOR signalling was assessed by western blotting.	cardamonin	25-35	mechanistic target of rapamycin kinase	Homo sapiens	39-43
31918264-0	2020	Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling.	cardamonin	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140
31918264-4	2020	At first, in DOX-treated mouse cardiomyocytes, CAR showed significantly cytoprotective effects through elevating nuclear factor erythroid-2 related factor 2 (Nrf2) signaling, and reducing the degradation of Nrf2.	cardamonin	47-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	113-156
31918264-4	2020	At first, in DOX-treated mouse cardiomyocytes, CAR showed significantly cytoprotective effects through elevating nuclear factor erythroid-2 related factor 2 (Nrf2) signaling, and reducing the degradation of Nrf2.	cardamonin	47-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	158-162
31918264-4	2020	At first, in DOX-treated mouse cardiomyocytes, CAR showed significantly cytoprotective effects through elevating nuclear factor erythroid-2 related factor 2 (Nrf2) signaling, and reducing the degradation of Nrf2.	cardamonin	47-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	207-211
31918264-8	2020	Then, in the DOX-induced animal model with cardiotoxicity, we confirmed that through improving Nrf2 signaling, CAR markedly suppressed oxidative stress, apoptosis and inflammatory response in hearts of mice, improving cardiac function eventually.	cardamonin	111-114	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
31918264-9	2020	Together, our findings demonstrated that CAR activated Nrf2-related cytoprotective system, and protected the heart from oxidative damage, apoptosis and inflammatory injury, suggesting that CAR might be a potential therapeutic strategy in the prevention of DOX-associated myocardiopathy.	cardamonin	41-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-59
31918264-9	2020	Together, our findings demonstrated that CAR activated Nrf2-related cytoprotective system, and protected the heart from oxidative damage, apoptosis and inflammatory injury, suggesting that CAR might be a potential therapeutic strategy in the prevention of DOX-associated myocardiopathy.	cardamonin	189-192	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-59
31455352-0	2019	Cardamonin inhibits breast cancer growth by repressing HIF-1alpha-dependent metabolic reprogramming.	cardamonin	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
31570032-3	2019	We found that cardamonin treatment alleviates intestinal disease, including recurring colitis and colitis-associated tumorigenesis, along with the reduced secretion of IL-1beta and TNF-alpha.	cardamonin	14-24	interleukin 1 beta	Homo sapiens	168-176
31570032-3	2019	We found that cardamonin treatment alleviates intestinal disease, including recurring colitis and colitis-associated tumorigenesis, along with the reduced secretion of IL-1beta and TNF-alpha.	cardamonin	14-24	tumor necrosis factor	Homo sapiens	181-190
31645009-6	2019	RESULTS: Cardamonin treatment inhibited lipid droplet accumulation and reduced the expression of the adipogenic proteins C/EBPalpha and FABP4, and the lipogenic proteins LPAATtheta, lipin 1, DGAT1, SREBP1, and FAS.	cardamonin	9-19	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	121-131
31645009-6	2019	RESULTS: Cardamonin treatment inhibited lipid droplet accumulation and reduced the expression of the adipogenic proteins C/EBPalpha and FABP4, and the lipogenic proteins LPAATtheta, lipin 1, DGAT1, SREBP1, and FAS.	cardamonin	9-19	fatty acid binding protein 4, adipocyte	Mus musculus	136-141
31645009-6	2019	RESULTS: Cardamonin treatment inhibited lipid droplet accumulation and reduced the expression of the adipogenic proteins C/EBPalpha and FABP4, and the lipogenic proteins LPAATtheta, lipin 1, DGAT1, SREBP1, and FAS.	cardamonin	9-19	glycerol-3-phosphate acyltransferase 3	Mus musculus	170-180
31645009-6	2019	RESULTS: Cardamonin treatment inhibited lipid droplet accumulation and reduced the expression of the adipogenic proteins C/EBPalpha and FABP4, and the lipogenic proteins LPAATtheta, lipin 1, DGAT1, SREBP1, and FAS.	cardamonin	9-19	lipin 1	Mus musculus	182-189
31645009-6	2019	RESULTS: Cardamonin treatment inhibited lipid droplet accumulation and reduced the expression of the adipogenic proteins C/EBPalpha and FABP4, and the lipogenic proteins LPAATtheta, lipin 1, DGAT1, SREBP1, and FAS.	cardamonin	9-19	diacylglycerol O-acyltransferase 1	Mus musculus	191-196
31645009-6	2019	RESULTS: Cardamonin treatment inhibited lipid droplet accumulation and reduced the expression of the adipogenic proteins C/EBPalpha and FABP4, and the lipogenic proteins LPAATtheta, lipin 1, DGAT1, SREBP1, and FAS.	cardamonin	9-19	sterol regulatory element binding transcription factor 1	Mus musculus	198-204
31455352-11	2019	RESULTS: Cardamonin inhibited growth of the triple negative breast cancer cell line MDA-MB-231 in vitro and in vivo by suppressing HIF-1alpha mediated cell metabolism.	cardamonin	9-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
31455352-12	2019	Cardamonin inhibited the expression of HIF-1alpha at mRNA and protein levels by repressing the mTOR/p70S6K pathway, and subsequently enhanced mitochondrial oxidative phosphorylation and induced reactive oxygen species (ROS) accumulation.	cardamonin	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
31455352-12	2019	Cardamonin inhibited the expression of HIF-1alpha at mRNA and protein levels by repressing the mTOR/p70S6K pathway, and subsequently enhanced mitochondrial oxidative phosphorylation and induced reactive oxygen species (ROS) accumulation.	cardamonin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	95-99
31455352-12	2019	Cardamonin inhibited the expression of HIF-1alpha at mRNA and protein levels by repressing the mTOR/p70S6K pathway, and subsequently enhanced mitochondrial oxidative phosphorylation and induced reactive oxygen species (ROS) accumulation.	cardamonin	0-10	ribosomal protein S6 kinase B1	Homo sapiens	100-106
31455352-13	2019	We also found that cardamonin inhibited the Nrf2-dependent ROS scavenging system which further increased intracellular ROS levels.	cardamonin	19-29	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
31393045-0	2019	Cardamonin induces G2/M arrest and apoptosis via activation of the JNK-FOXO3a pathway in breast cancer cells.	cardamonin	0-10	mitogen-activated protein kinase 8	Homo sapiens	67-70
31393045-0	2019	Cardamonin induces G2/M arrest and apoptosis via activation of the JNK-FOXO3a pathway in breast cancer cells.	cardamonin	0-10	forkhead box O3	Homo sapiens	71-77
31393045-6	2019	Quenching of ROS by overexpression of catalase also blocked CD-induced cell cycle arrest and apoptosis.	cardamonin	60-62	catalase	Homo sapiens	38-46
31393045-7	2019	We showed that CD enhanced the expression and nuclear translocation of Forkhead box O3 (FOXO3a) via upstream c-Jun N-terminal kinase, inducing the expression of FOXO3a and its target genes, including p21, p27, and Bim.	cardamonin	15-17	forkhead box O3	Homo sapiens	71-86
31393045-7	2019	We showed that CD enhanced the expression and nuclear translocation of Forkhead box O3 (FOXO3a) via upstream c-Jun N-terminal kinase, inducing the expression of FOXO3a and its target genes, including p21, p27, and Bim.	cardamonin	15-17	forkhead box O3	Homo sapiens	88-94
31393045-7	2019	We showed that CD enhanced the expression and nuclear translocation of Forkhead box O3 (FOXO3a) via upstream c-Jun N-terminal kinase, inducing the expression of FOXO3a and its target genes, including p21, p27, and Bim.	cardamonin	15-17	forkhead box O3	Homo sapiens	161-167
31393045-7	2019	We showed that CD enhanced the expression and nuclear translocation of Forkhead box O3 (FOXO3a) via upstream c-Jun N-terminal kinase, inducing the expression of FOXO3a and its target genes, including p21, p27, and Bim.	cardamonin	15-17	H3 histone pseudogene 16	Homo sapiens	200-203
31393045-7	2019	We showed that CD enhanced the expression and nuclear translocation of Forkhead box O3 (FOXO3a) via upstream c-Jun N-terminal kinase, inducing the expression of FOXO3a and its target genes, including p21, p27, and Bim.	cardamonin	15-17	interferon alpha inducible protein 27	Homo sapiens	205-208
31393045-9	2019	The addition of NAC markedly reversed these effects, knockdown of FOXO3a using small interfering RNA also decreased CD-induced G2/M arrest and apoptosis.	cardamonin	116-118	forkhead box O3	Homo sapiens	66-72
30640793-5	2019	In A549 and H460 cells, cardamonin induced apoptosis by activating caspase-3, upregulating Bax, and downregulating Bcl-2.	cardamonin	24-34	BCL2 apoptosis regulator	Homo sapiens	115-120
31384534-3	2019	Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli.	cardamonin	19-22	NLR family, pyrin domain containing 3	Mus musculus	57-62
31384534-4	2019	Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome.	cardamonin	29-32	NLR family, pyrin domain containing 3	Mus musculus	75-80
31384534-4	2019	Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome.	cardamonin	29-32	NLR family, CARD domain containing 4	Mus musculus	89-94
31384534-6	2019	We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.	cardamonin	25-28	NLR family, pyrin domain containing 3	Mus musculus	44-49
31384534-7	2019	Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1beta production induced by LPS in vivo, which is shown to be NLRP3 dependent.	cardamonin	13-16	interleukin 1 beta	Mus musculus	97-105
31384534-7	2019	Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1beta production induced by LPS in vivo, which is shown to be NLRP3 dependent.	cardamonin	13-16	NLR family, pyrin domain containing 3	Mus musculus	162-167
31384534-8	2019	In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases.	cardamonin	36-39	NLR family, pyrin domain containing 3	Mus musculus	86-91
31384534-8	2019	In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases.	cardamonin	36-39	NLR family, pyrin domain containing 3	Mus musculus	151-156
30640793-5	2019	In A549 and H460 cells, cardamonin induced apoptosis by activating caspase-3, upregulating Bax, and downregulating Bcl-2.	cardamonin	24-34	caspase 3	Homo sapiens	67-76
30640793-5	2019	In A549 and H460 cells, cardamonin induced apoptosis by activating caspase-3, upregulating Bax, and downregulating Bcl-2.	cardamonin	24-34	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
32002963-0	2018	Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells.	cardamonin	21-31	CREB regulated transcription coactivator 1	Mus musculus	51-57
30142469-6	2018	Cardamonin inhibited NF-kappaB activation as well as COX-2 expression induced by TLR agonists.	cardamonin	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
30071202-0	2018	Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.	cardamonin	0-10	NAD(P)H dehydrogenase, quinone 1	Mus musculus	136-140
30071202-2	2018	The results showed that oral cardamonin significantly inhibited dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice, evidenced by improvement of disease activity index scores, myeloperoxidase activity, length shortening and histopathological changes of colons.	cardamonin	29-39	myeloperoxidase	Mus musculus	225-240
30071202-5	2018	In vitro, cardamonin inhibited NLRP3 inflammasome activation in THP-1 and bone marrow-derived macrophages.	cardamonin	10-20	NLR family, pyrin domain containing 3	Mus musculus	31-36
31949683-10	2018	Apoptosis and the expression of p-AKT and C-myc in the SAH + cardamonin group were significantly lower than in the SAH and SAH + vehicle groups (P < 0.05), while alpha-SMA expression was higher than in the SAH and SAH + vehicle groups (P < 0.01).	cardamonin	61-71	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	42-47
30071202-0	2018	Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.	cardamonin	0-10	NLR family, pyrin domain containing 3	Mus musculus	90-95
30071202-0	2018	Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.	cardamonin	0-10	aryl-hydrocarbon receptor	Mus musculus	127-130
30071202-0	2018	Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.	cardamonin	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
32002963-12	2018	The inhibitory effect of cardamonin on the phosphorylation of mTOR and S6K1 was eliminated by Raptor knockdown with siRNA, whereas this effect of cardamonin was stronger than that of rapamycin and AZD8055 in Raptor over-expression cells.	cardamonin	25-35	ribosomal protein S6 kinase B1	Homo sapiens	71-75
32002963-12	2018	The inhibitory effect of cardamonin on the phosphorylation of mTOR and S6K1 was eliminated by Raptor knockdown with siRNA, whereas this effect of cardamonin was stronger than that of rapamycin and AZD8055 in Raptor over-expression cells.	cardamonin	25-35	regulatory associated protein of MTOR complex 1	Homo sapiens	94-100
32002963-12	2018	The inhibitory effect of cardamonin on the phosphorylation of mTOR and S6K1 was eliminated by Raptor knockdown with siRNA, whereas this effect of cardamonin was stronger than that of rapamycin and AZD8055 in Raptor over-expression cells.	cardamonin	25-35	regulatory associated protein of MTOR complex 1	Homo sapiens	208-214
32002963-12	2018	The inhibitory effect of cardamonin on the phosphorylation of mTOR and S6K1 was eliminated by Raptor knockdown with siRNA, whereas this effect of cardamonin was stronger than that of rapamycin and AZD8055 in Raptor over-expression cells.	cardamonin	146-156	regulatory associated protein of MTOR complex 1	Homo sapiens	94-100
32002963-12	2018	The inhibitory effect of cardamonin on the phosphorylation of mTOR and S6K1 was eliminated by Raptor knockdown with siRNA, whereas this effect of cardamonin was stronger than that of rapamycin and AZD8055 in Raptor over-expression cells.	cardamonin	146-156	regulatory associated protein of MTOR complex 1	Homo sapiens	208-214
32002963-13	2018	Cell viability was inhibited by cardamonin in both Raptor knockdown and Raptor over-expression cells, which was consistent with the inhibitory effect of cardamonin on mTOR.	cardamonin	32-42	regulatory associated protein of MTOR complex 1	Homo sapiens	51-57
32002963-13	2018	Cell viability was inhibited by cardamonin in both Raptor knockdown and Raptor over-expression cells, which was consistent with the inhibitory effect of cardamonin on mTOR.	cardamonin	32-42	regulatory associated protein of MTOR complex 1	Homo sapiens	72-78
32002963-13	2018	Cell viability was inhibited by cardamonin in both Raptor knockdown and Raptor over-expression cells, which was consistent with the inhibitory effect of cardamonin on mTOR.	cardamonin	153-163	mechanistic target of rapamycin kinase	Homo sapiens	167-171
32002963-14	2018	CONCLUSION: These findings demonstrated that the autophagy induced by cardamonin was associated with mTORC1 inhibition through decreasing the protein level of Raptor in SKOV3 cells.	cardamonin	70-80	CREB regulated transcription coactivator 1	Mus musculus	101-107
32002963-14	2018	CONCLUSION: These findings demonstrated that the autophagy induced by cardamonin was associated with mTORC1 inhibition through decreasing the protein level of Raptor in SKOV3 cells.	cardamonin	70-80	regulatory associated protein of MTOR complex 1	Homo sapiens	159-165
32002963-2	2018	Cardamonin exhibits anti-proliferative activity through inhibiting mTOR.	cardamonin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	67-71
32002963-3	2018	In this study, the effect of cardamonin on autophagy and its mechanism on mTOR inhibition were investigated.	cardamonin	29-39	mechanistic target of rapamycin kinase	Homo sapiens	74-78
32002963-6	2018	The mechanism of cardamonin on mTORC1 inhibition was investigated by Raptor siRNA and Raptor over-expression.	cardamonin	17-27	CREB regulated transcription coactivator 1	Mus musculus	31-37
32002963-6	2018	The mechanism of cardamonin on mTORC1 inhibition was investigated by Raptor siRNA and Raptor over-expression.	cardamonin	17-27	regulatory associated protein of MTOR complex 1	Homo sapiens	69-75
32002963-6	2018	The mechanism of cardamonin on mTORC1 inhibition was investigated by Raptor siRNA and Raptor over-expression.	cardamonin	17-27	regulatory associated protein of MTOR complex 1	Homo sapiens	86-92
32002963-9	2018	Cell apoptosis and the levels of cleaved PARP and Caspase-3 were increased by cardamonin.	cardamonin	78-88	collagen type XI alpha 2 chain	Homo sapiens	41-45
32002963-9	2018	Cell apoptosis and the levels of cleaved PARP and Caspase-3 were increased by cardamonin.	cardamonin	78-88	caspase 3	Homo sapiens	50-59
32002963-10	2018	Cardamonin inhibited the phosphorylation of mTOR and ribosome S6 protein kinase 1 (S6K1) as well as the protein level of regulatory associated protein of mTOR (Raptor).	cardamonin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	44-48
32002963-10	2018	Cardamonin inhibited the phosphorylation of mTOR and ribosome S6 protein kinase 1 (S6K1) as well as the protein level of regulatory associated protein of mTOR (Raptor).	cardamonin	0-10	ribosomal protein S6 kinase B1	Homo sapiens	62-81
32002963-10	2018	Cardamonin inhibited the phosphorylation of mTOR and ribosome S6 protein kinase 1 (S6K1) as well as the protein level of regulatory associated protein of mTOR (Raptor).	cardamonin	0-10	ribosomal protein S6 kinase B1	Homo sapiens	83-87
32002963-10	2018	Cardamonin inhibited the phosphorylation of mTOR and ribosome S6 protein kinase 1 (S6K1) as well as the protein level of regulatory associated protein of mTOR (Raptor).	cardamonin	0-10	regulatory associated protein of MTOR complex 1	Homo sapiens	121-158
32002963-10	2018	Cardamonin inhibited the phosphorylation of mTOR and ribosome S6 protein kinase 1 (S6K1) as well as the protein level of regulatory associated protein of mTOR (Raptor).	cardamonin	0-10	regulatory associated protein of MTOR complex 1	Homo sapiens	160-166
32002963-12	2018	The inhibitory effect of cardamonin on the phosphorylation of mTOR and S6K1 was eliminated by Raptor knockdown with siRNA, whereas this effect of cardamonin was stronger than that of rapamycin and AZD8055 in Raptor over-expression cells.	cardamonin	25-35	mechanistic target of rapamycin kinase	Homo sapiens	62-66
32454640-4	2018	The binding rate of PEO-1 cells to fibronectin was also investigated in the presence of either different concentrations of cardamonin, which inhibits the accumulation of beta-catenin, or different concentrations of FPA 124, which is a specific inhibitor for the PKB/Akt signal pathway, using RTCA.	cardamonin	123-133	fibronectin 1	Homo sapiens	35-46
29928339-0	2018	Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF-kappaB pathway in vitro.	cardamonin	0-10	serine protease 50	Homo sapiens	73-78
29928339-0	2018	Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF-kappaB pathway in vitro.	cardamonin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	79-88
27580587-8	2017	These results suggest the involvement of the Wnt/beta-catenin signaling in the CD-induced EMT reversion of BT-549 cells.	cardamonin	79-81	catenin beta 1	Homo sapiens	49-61
29456744-10	2018	These results demonstrated that the combinatorial effects of cardamonin and cisplatin on anti-proliferation were enhanced by suppressing the expression of anti-apoptotic proteins and activation of mTOR in ovarian cancer cells.	cardamonin	61-71	mechanistic target of rapamycin kinase	Homo sapiens	197-201
28966130-5	2017	Cardamonin (CDN) is an anti-inflammatory molecule and a novel iNOS inhibitor, and Nomega-Nitro-L-arginine (L-NNA) is a NOS inhibitor.	cardamonin	12-15	nitric oxide synthase 2	Rattus norvegicus	62-66
27580587-3	2017	The results show that CD exhibits cytotoxicity by inducing apoptosis and cell cycle arrest in TNBC cells via modulation of Bcl-2, Bax, cyt-C, cleaved caspase-3, and PARP.	cardamonin	22-24	BCL2 apoptosis regulator	Homo sapiens	123-128
27580587-3	2017	The results show that CD exhibits cytotoxicity by inducing apoptosis and cell cycle arrest in TNBC cells via modulation of Bcl-2, Bax, cyt-C, cleaved caspase-3, and PARP.	cardamonin	22-24	BCL2 associated X, apoptosis regulator	Homo sapiens	130-133
27580587-3	2017	The results show that CD exhibits cytotoxicity by inducing apoptosis and cell cycle arrest in TNBC cells via modulation of Bcl-2, Bax, cyt-C, cleaved caspase-3, and PARP.	cardamonin	22-24	collagen type XI alpha 2 chain	Homo sapiens	165-169
27580587-4	2017	We find that CD significantly increases expression of the epithelial marker E-cadherin, while reciprocally decreasing expression of mesenchymal markers such as snail, slug, and vimentin in BT-549 cells.	cardamonin	13-15	cadherin 1	Homo sapiens	76-86
27580587-4	2017	We find that CD significantly increases expression of the epithelial marker E-cadherin, while reciprocally decreasing expression of mesenchymal markers such as snail, slug, and vimentin in BT-549 cells.	cardamonin	13-15	vimentin	Homo sapiens	177-185
27580587-6	2017	CD markedly reduces stability and nuclear translocation of beta-catenin, accompanied with downregulation of beta-catenin target genes.	cardamonin	0-2	catenin beta 1	Homo sapiens	59-71
27580587-6	2017	CD markedly reduces stability and nuclear translocation of beta-catenin, accompanied with downregulation of beta-catenin target genes.	cardamonin	0-2	catenin beta 1	Homo sapiens	108-120
27580587-7	2017	Using the TopFlash luciferase reporter assay, we reveal CD as a specific inhibitor of the Wnt3a-induced signaling.	cardamonin	56-58	Wnt family member 3A	Homo sapiens	90-95
28271112-8	2017	Pretreatment of PC12 cells with CD dose-dependently upregulated the expression of phase II antioxidant molecules governed by Nrf2.	cardamonin	32-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
28271112-10	2017	Our results demonstrate that CD is a novel small molecule activator of Nrf2 in PC12 cells, and suggest that CD may be a potential candidate for the prevention of oxidative stress-mediated neurodegenerative disorders.	cardamonin	29-31	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-75
27580587-9	2017	Notably, CD restores the glycogen synthase kinase-3beta (GSK3beta) activity, required for beta-catenin destruction via the proteasome-mediated system, by inhibiting the phosphorylation of GSK3beta by Akt.	cardamonin	9-11	glycogen synthase kinase 3 beta	Homo sapiens	25-55
27580587-9	2017	Notably, CD restores the glycogen synthase kinase-3beta (GSK3beta) activity, required for beta-catenin destruction via the proteasome-mediated system, by inhibiting the phosphorylation of GSK3beta by Akt.	cardamonin	9-11	glycogen synthase kinase 3 beta	Homo sapiens	57-65
27580587-9	2017	Notably, CD restores the glycogen synthase kinase-3beta (GSK3beta) activity, required for beta-catenin destruction via the proteasome-mediated system, by inhibiting the phosphorylation of GSK3beta by Akt.	cardamonin	9-11	catenin beta 1	Homo sapiens	90-102
27580587-9	2017	Notably, CD restores the glycogen synthase kinase-3beta (GSK3beta) activity, required for beta-catenin destruction via the proteasome-mediated system, by inhibiting the phosphorylation of GSK3beta by Akt.	cardamonin	9-11	glycogen synthase kinase 3 beta	Homo sapiens	188-196
27900636-3	2017	Hence, in the present study, we evaluated the potential of cardamonin (CD), a 2",4"-dihydroxy-6"-methoxychalcone, to modulate STAT3 activation in prostate cancer (PC) cells and found that this chalcone can indeed exhibit significant anticancer effects through negatively regulating STAT3 activation by diverse molecular mechanism(s).	cardamonin	59-69	signal transducer and activator of transcription 3	Homo sapiens	126-131
27900636-3	2017	Hence, in the present study, we evaluated the potential of cardamonin (CD), a 2",4"-dihydroxy-6"-methoxychalcone, to modulate STAT3 activation in prostate cancer (PC) cells and found that this chalcone can indeed exhibit significant anticancer effects through negatively regulating STAT3 activation by diverse molecular mechanism(s).	cardamonin	59-69	signal transducer and activator of transcription 3	Homo sapiens	282-287
27900636-3	2017	Hence, in the present study, we evaluated the potential of cardamonin (CD), a 2",4"-dihydroxy-6"-methoxychalcone, to modulate STAT3 activation in prostate cancer (PC) cells and found that this chalcone can indeed exhibit significant anticancer effects through negatively regulating STAT3 activation by diverse molecular mechanism(s).	cardamonin	71-73	signal transducer and activator of transcription 3	Homo sapiens	126-131
27900636-4	2017	CD suppressed STAT3 phosphorylation, nuclear translocation and DNA binding ability in PC cells.	cardamonin	0-2	signal transducer and activator of transcription 3	Homo sapiens	14-19
27900636-5	2017	Computational modeling revealed that CD can bind directly to the Src Homology 2 domain of STAT3 and also effectively inhibit its dimerization.	cardamonin	37-39	signal transducer and activator of transcription 3	Homo sapiens	90-95
27900636-7	2017	Overall, the data indicates that the potential application of CD as a STAT3 blocker can mitigate both the growth and survival of PC cells.	cardamonin	62-64	signal transducer and activator of transcription 3	Homo sapiens	70-75
26251468-3	2015	In the present study, we found that cardamonin markedly ameliorated dextran sulfate sodium-induced mouse body weight loss, diarrhea, colon shortening, spleen swelling, and histological damage, which correlated with a decline in the activity of myeloperoxidase and the production of nitric oxide, tumor necrosis factor-alpha and interleukin-6 in the colon.	cardamonin	36-46	myeloperoxidase	Mus musculus	244-259
26506421-5	2016	Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-kappaB/IKBalpha and Stat3.	cardamonin	14-24	mast cell protease 1	Mus musculus	109-114
26506421-5	2016	Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-kappaB/IKBalpha and Stat3.	cardamonin	14-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-142
26506421-5	2016	Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-kappaB/IKBalpha and Stat3.	cardamonin	14-24	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	143-151
26506421-5	2016	Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-kappaB/IKBalpha and Stat3.	cardamonin	14-24	signal transducer and activator of transcription 3	Mus musculus	156-161
26855338-7	2016	In contrast, overexpression of TSP50 greatly decreased the cell sensitivity to the inhibitory effect of cardamonin and reversed the decreased tumor-inhibitory effect of cardamonin.	cardamonin	104-114	serine protease 50	Homo sapiens	31-36
26698667-4	2016	Here, we have studied the interplay between Se and the secondary plant metabolite cardamonin, an Nrf2-activating chalcone, in the regulation of Nrf2-controlled antioxidant enzymes.	cardamonin	82-92	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
26698667-4	2016	Here, we have studied the interplay between Se and the secondary plant metabolite cardamonin, an Nrf2-activating chalcone, in the regulation of Nrf2-controlled antioxidant enzymes.	cardamonin	82-92	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
26698667-8	2016	However, cardamonin treatment did not result in elevated GPx or TrxR activity and protein levels, possibly relating to a concomitant down-regulation of O-phosphoseryl-tRNA(Sec) kinase (PSTK), an enzyme involved in translation of selenoprotein mRNAs.	cardamonin	9-19	phosphoseryl-tRNA kinase	Homo sapiens	152-183
26698667-8	2016	However, cardamonin treatment did not result in elevated GPx or TrxR activity and protein levels, possibly relating to a concomitant down-regulation of O-phosphoseryl-tRNA(Sec) kinase (PSTK), an enzyme involved in translation of selenoprotein mRNAs.	cardamonin	9-19	phosphoseryl-tRNA kinase	Homo sapiens	185-189
26698667-9	2016	On the other hand, induction of the Nrf2-regulated enzyme heme oxygenase 1 (HO-1) by cardamonin was diminished in Se-replete compared to Se-deficient cells.	cardamonin	85-95	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
26698667-9	2016	On the other hand, induction of the Nrf2-regulated enzyme heme oxygenase 1 (HO-1) by cardamonin was diminished in Se-replete compared to Se-deficient cells.	cardamonin	85-95	heme oxygenase 1	Homo sapiens	58-74
26506421-5	2016	Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-kappaB/IKBalpha and Stat3.	cardamonin	14-24	interleukin 6	Mus musculus	94-98
26506421-5	2016	Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-kappaB/IKBalpha and Stat3.	cardamonin	14-24	chemokine (C-X-C motif) ligand 15	Mus musculus	100-104
26150336-2	2015	In the present study, we investigated the effects of cardamonin (3,4,2,4-tetrahydroxychalcone) on the self-renewal and apoptosis of GSCs, and if its action is associated with signal transducer and activator of transcription 3 (STAT3) pathway.	cardamonin	53-63	signal transducer and activator of transcription 3	Mus musculus	227-232
26251468-3	2015	In the present study, we found that cardamonin markedly ameliorated dextran sulfate sodium-induced mouse body weight loss, diarrhea, colon shortening, spleen swelling, and histological damage, which correlated with a decline in the activity of myeloperoxidase and the production of nitric oxide, tumor necrosis factor-alpha and interleukin-6 in the colon.	cardamonin	36-46	interleukin 6	Mus musculus	328-341
26266258-5	2015	We found that cardamonin reduced the miR-21 expression induced by VEGF in HUVECs.	cardamonin	14-24	microRNA 21	Homo sapiens	37-43
25767682-3	2015	In the present study, we examined, by Western blot, reverse transcription polymerase chain reaction (RT-PCR), and confocal microscopy, the effects of cardamonin (CDN) on transforming growth factor-beta1 (TGF-beta1)-induced EMT of A549 lung adenocarcinoma cell lines.	cardamonin	150-160	transforming growth factor beta 1	Homo sapiens	204-213
25767682-3	2015	In the present study, we examined, by Western blot, reverse transcription polymerase chain reaction (RT-PCR), and confocal microscopy, the effects of cardamonin (CDN) on transforming growth factor-beta1 (TGF-beta1)-induced EMT of A549 lung adenocarcinoma cell lines.	cardamonin	162-165	transforming growth factor beta 1	Homo sapiens	204-213
25767682-5	2015	CDN suppressed N-cadherin expression and restored E-cadherin expression.	cardamonin	0-3	cadherin 2	Homo sapiens	15-25
25767682-5	2015	CDN suppressed N-cadherin expression and restored E-cadherin expression.	cardamonin	0-3	cadherin 1	Homo sapiens	50-60
25767682-6	2015	Further, TGF-beta1 induced migration and invasion of A549 cancer cells, which was suppressed by CDN.	cardamonin	96-99	transforming growth factor beta 1	Homo sapiens	9-18
25767682-8	2015	Protein serine/threonine phosphatase 2A (PP2A) expression in A549 cancer cells was reduced by TGF-beta1 but CDN restored it.	cardamonin	108-111	protein phosphatase 2 phosphatase activator	Homo sapiens	41-45
25767682-9	2015	The overall data suggested that CDN suppresses TGF-beta1-induced EMT via PP2A restoration, making it a potential new drug candidate that controls metastasis.	cardamonin	32-35	transforming growth factor beta 1	Homo sapiens	47-56
25767682-9	2015	The overall data suggested that CDN suppresses TGF-beta1-induced EMT via PP2A restoration, making it a potential new drug candidate that controls metastasis.	cardamonin	32-35	protein phosphatase 2 phosphatase activator	Homo sapiens	73-77
26266258-5	2015	We found that cardamonin reduced the miR-21 expression induced by VEGF in HUVECs.	cardamonin	14-24	vascular endothelial growth factor A	Homo sapiens	66-70
25285619-8	2014	CDN suppressed the binding of TXA2 receptor with Gh/Tgase-2, which also acts as a G protein involved in TXA2 signaling.	cardamonin	0-3	transglutaminase 2	Homo sapiens	52-59
25285619-9	2014	These results suggested that CDN suppresses TXA2 receptor agonist-induced scratching by suppressing TXA2 signaling, specifically via blocking of the binding of Gh/Tgase-2 to TXA2 receptor.	cardamonin	29-32	transglutaminase 2	Homo sapiens	163-170
24714064-7	2014	Instead, cardamonin inhibited the phosphorylation of Akt and nuclear transduction of NF-kappaB and further reduced the expression of the adhesion molecules ICAM-1 and VCAM-1 in HTNV-infected HUVECs.	cardamonin	9-19	vascular cell adhesion molecule 1	Homo sapiens	167-173
24845100-0	2014	The chalcones cardamonin and flavokawain B inhibit the differentiation of preadipocytes to adipocytes by activating ERK.	cardamonin	14-24	mitogen-activated protein kinase 1	Mus musculus	116-119
24845100-4	2014	In the further study, cardamonin and flavokawain B inhibited lipid accumulation by downregulating the expression of CCAAT/enhancer binding protein (C/EBP)-beta, C/EBPalpha, and peroxisome proliferator-activated receptor-gamma (PPARgamma) at both mRNA and protein levels.	cardamonin	22-32	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	148-159
24845100-4	2014	In the further study, cardamonin and flavokawain B inhibited lipid accumulation by downregulating the expression of CCAAT/enhancer binding protein (C/EBP)-beta, C/EBPalpha, and peroxisome proliferator-activated receptor-gamma (PPARgamma) at both mRNA and protein levels.	cardamonin	22-32	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	161-171
24845100-4	2014	In the further study, cardamonin and flavokawain B inhibited lipid accumulation by downregulating the expression of CCAAT/enhancer binding protein (C/EBP)-beta, C/EBPalpha, and peroxisome proliferator-activated receptor-gamma (PPARgamma) at both mRNA and protein levels.	cardamonin	22-32	peroxisome proliferator activated receptor gamma	Mus musculus	177-225
24845100-4	2014	In the further study, cardamonin and flavokawain B inhibited lipid accumulation by downregulating the expression of CCAAT/enhancer binding protein (C/EBP)-beta, C/EBPalpha, and peroxisome proliferator-activated receptor-gamma (PPARgamma) at both mRNA and protein levels.	cardamonin	22-32	peroxisome proliferator activated receptor gamma	Mus musculus	227-236
24845100-5	2014	Cardamonin and flavokawain B also increased phosphorylation of extracellular signal-regulated kinase (ERK) in the early phase of adipocyte differentiation.	cardamonin	0-10	mitogen-activated protein kinase 1	Mus musculus	63-100
24845100-5	2014	Cardamonin and flavokawain B also increased phosphorylation of extracellular signal-regulated kinase (ERK) in the early phase of adipocyte differentiation.	cardamonin	0-10	mitogen-activated protein kinase 1	Mus musculus	102-105
24845100-7	2014	Moreover, cardamonin and flavokawain B also modulated the secretion of C-reactive protein, dipeptidyl peptidase IV, interleukin-6, tumor necrosis factor-alpha and fibroblast growth factor-21 in mature adipocytes.	cardamonin	10-20	C-reactive protein, pentraxin-related	Mus musculus	71-89
24845100-7	2014	Moreover, cardamonin and flavokawain B also modulated the secretion of C-reactive protein, dipeptidyl peptidase IV, interleukin-6, tumor necrosis factor-alpha and fibroblast growth factor-21 in mature adipocytes.	cardamonin	10-20	dipeptidylpeptidase 4	Mus musculus	91-114
24845100-7	2014	Moreover, cardamonin and flavokawain B also modulated the secretion of C-reactive protein, dipeptidyl peptidase IV, interleukin-6, tumor necrosis factor-alpha and fibroblast growth factor-21 in mature adipocytes.	cardamonin	10-20	interleukin 6	Mus musculus	116-158
24714064-4	2014	The effect of cardamonin on the HTNV-induced phosphorylation of Akt and DNA-binding activity of NF-kappaB were determined using Western blot analysis and electrophoretic mobility shift assays (EMSAs), respectively.	cardamonin	14-24	AKT serine/threonine kinase 1	Homo sapiens	64-67
24714064-4	2014	The effect of cardamonin on the HTNV-induced phosphorylation of Akt and DNA-binding activity of NF-kappaB were determined using Western blot analysis and electrophoretic mobility shift assays (EMSAs), respectively.	cardamonin	14-24	nuclear factor kappa B subunit 1	Homo sapiens	96-105
24714064-7	2014	Instead, cardamonin inhibited the phosphorylation of Akt and nuclear transduction of NF-kappaB and further reduced the expression of the adhesion molecules ICAM-1 and VCAM-1 in HTNV-infected HUVECs.	cardamonin	9-19	AKT serine/threonine kinase 1	Homo sapiens	53-56
24714064-7	2014	Instead, cardamonin inhibited the phosphorylation of Akt and nuclear transduction of NF-kappaB and further reduced the expression of the adhesion molecules ICAM-1 and VCAM-1 in HTNV-infected HUVECs.	cardamonin	9-19	nuclear factor kappa B subunit 1	Homo sapiens	85-94
24714064-7	2014	Instead, cardamonin inhibited the phosphorylation of Akt and nuclear transduction of NF-kappaB and further reduced the expression of the adhesion molecules ICAM-1 and VCAM-1 in HTNV-infected HUVECs.	cardamonin	9-19	intercellular adhesion molecule 1	Homo sapiens	156-162
32260928-6	2013	Furthermore, the addition of cardamonin, a Wnt/beta-catenin signalling inhibitor, reduced the pro-cementogenesis effect of the bredigite extracts, indicating the involvement of the Wnt/beta-catenin signalling pathway in the cementogenesis of PDLCs induced by bredigite extracts.	cardamonin	29-39	catenin beta 1	Homo sapiens	47-59
24508654-11	2014	Both rapamycin and cardamonin decreased the phosphorylation of mTOR and p70S6K in two kinds of transfected cells.	cardamonin	19-29	mechanistic target of rapamycin kinase	Homo sapiens	63-67
24508654-11	2014	Both rapamycin and cardamonin decreased the phosphorylation of mTOR and p70S6K in two kinds of transfected cells.	cardamonin	19-29	ribosomal protein S6 kinase B1	Homo sapiens	72-78
24398147-0	2014	Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 and transglutaminase-2.	cardamonin	34-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-88
24398147-4	2014	CDN suppressed the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-kappaB) in a concentration-dependent manner, and restored the expression of IkappaB in MG63 and Raw264.7 cells.	cardamonin	0-3	transglutaminase 2	Homo sapiens	33-40
24398147-4	2014	CDN suppressed the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-kappaB) in a concentration-dependent manner, and restored the expression of IkappaB in MG63 and Raw264.7 cells.	cardamonin	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-58
24398147-4	2014	CDN suppressed the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-kappaB) in a concentration-dependent manner, and restored the expression of IkappaB in MG63 and Raw264.7 cells.	cardamonin	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-65
24398147-4	2014	CDN suppressed the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-kappaB) in a concentration-dependent manner, and restored the expression of IkappaB in MG63 and Raw264.7 cells.	cardamonin	0-3	RELA proto-oncogene, NF-kB subunit	Homo sapiens	72-75
32260928-6	2013	Furthermore, the addition of cardamonin, a Wnt/beta-catenin signalling inhibitor, reduced the pro-cementogenesis effect of the bredigite extracts, indicating the involvement of the Wnt/beta-catenin signalling pathway in the cementogenesis of PDLCs induced by bredigite extracts.	cardamonin	29-39	catenin beta 1	Homo sapiens	185-197
23512499-8	2013	Cardamonin increased the 2-deoxyglucose uptake and glycogen concentration, which was reduced by insulin resistance.	cardamonin	0-10	insulin	Homo sapiens	96-103
23512499-9	2013	As with rapamycin, cardamonin inhibited the activity of the mammalian target of rapamycin and S6 kinase 1, decreased the Ser 636/639 phosphorylation of insulin receptor substrate-1 and increased the activation of protein kinase B.	cardamonin	19-29	mechanistic target of rapamycin kinase	Homo sapiens	60-89
23691159-6	2013	We found that treatment of monocytes with cardamonin suppressed RANKL-induced NF-kappaB activation and this suppression correlated with inhibition of IkappaBalpha kinase and of phosphorylation and degradation of IkappaBalpha, an inhibitor of NF-kappaB.	cardamonin	42-52	TNF superfamily member 11	Homo sapiens	64-69
23691159-6	2013	We found that treatment of monocytes with cardamonin suppressed RANKL-induced NF-kappaB activation and this suppression correlated with inhibition of IkappaBalpha kinase and of phosphorylation and degradation of IkappaBalpha, an inhibitor of NF-kappaB.	cardamonin	42-52	nuclear factor kappa B subunit 1	Homo sapiens	78-87
23691159-6	2013	We found that treatment of monocytes with cardamonin suppressed RANKL-induced NF-kappaB activation and this suppression correlated with inhibition of IkappaBalpha kinase and of phosphorylation and degradation of IkappaBalpha, an inhibitor of NF-kappaB.	cardamonin	42-52	NFKB inhibitor alpha	Homo sapiens	150-162
23691159-6	2013	We found that treatment of monocytes with cardamonin suppressed RANKL-induced NF-kappaB activation and this suppression correlated with inhibition of IkappaBalpha kinase and of phosphorylation and degradation of IkappaBalpha, an inhibitor of NF-kappaB.	cardamonin	42-52	NFKB inhibitor alpha	Homo sapiens	212-224
23691159-6	2013	We found that treatment of monocytes with cardamonin suppressed RANKL-induced NF-kappaB activation and this suppression correlated with inhibition of IkappaBalpha kinase and of phosphorylation and degradation of IkappaBalpha, an inhibitor of NF-kappaB.	cardamonin	42-52	nuclear factor kappa B subunit 1	Homo sapiens	242-251
23512499-9	2013	As with rapamycin, cardamonin inhibited the activity of the mammalian target of rapamycin and S6 kinase 1, decreased the Ser 636/639 phosphorylation of insulin receptor substrate-1 and increased the activation of protein kinase B.	cardamonin	19-29	insulin receptor substrate 1	Homo sapiens	152-180
23201552-7	2013	CDN suppressed the expression of Tgase-2, MMP-2, NF-kappaB and MMP-9 in HT-1080 cells, and suppressed MMP-2 and MMP-9 activities.	cardamonin	0-3	transglutaminase 2	Homo sapiens	33-40
23241322-9	2013	Inhibition of beta-catenin (cardamonin; 10 mumol/l) or GSK3-alpha/beta (LiCl; 5 mmol/l) also suppressed changes in theta, further supporting the hypothesis that MSC-mediated Cx43 upregulation occurs in part through secreted Wnt ligands and activation of the canonical Wnt signaling pathway.	cardamonin	28-38	catenin beta 1	Homo sapiens	14-26
23201552-7	2013	CDN suppressed the expression of Tgase-2, MMP-2, NF-kappaB and MMP-9 in HT-1080 cells, and suppressed MMP-2 and MMP-9 activities.	cardamonin	0-3	matrix metallopeptidase 2	Homo sapiens	42-47
23201552-7	2013	CDN suppressed the expression of Tgase-2, MMP-2, NF-kappaB and MMP-9 in HT-1080 cells, and suppressed MMP-2 and MMP-9 activities.	cardamonin	0-3	matrix metallopeptidase 9	Homo sapiens	63-68
23201552-7	2013	CDN suppressed the expression of Tgase-2, MMP-2, NF-kappaB and MMP-9 in HT-1080 cells, and suppressed MMP-2 and MMP-9 activities.	cardamonin	0-3	matrix metallopeptidase 2	Homo sapiens	102-107
23201552-7	2013	CDN suppressed the expression of Tgase-2, MMP-2, NF-kappaB and MMP-9 in HT-1080 cells, and suppressed MMP-2 and MMP-9 activities.	cardamonin	0-3	matrix metallopeptidase 9	Homo sapiens	112-117
23201552-9	2013	Migration of various cancer cells having high levels of Tgase-2 were also inhibited by CDN.	cardamonin	87-90	transglutaminase 2	Homo sapiens	56-63
23201552-10	2013	CDN and Alpinia katsumadai extracts also directly inhibited the activity of Tgase-2.	cardamonin	0-3	transglutaminase 2	Homo sapiens	76-83
23201552-11	2013	SIGNIFICANCE: CDN inhibits migration of several cancer cell lines expressing Tgase-2 via suppression of Tgase-2 expression and inhibition of Tgase-2 activity.	cardamonin	14-17	transglutaminase 2	Homo sapiens	77-84
23201552-11	2013	SIGNIFICANCE: CDN inhibits migration of several cancer cell lines expressing Tgase-2 via suppression of Tgase-2 expression and inhibition of Tgase-2 activity.	cardamonin	14-17	transglutaminase 2	Homo sapiens	104-111
23201552-11	2013	SIGNIFICANCE: CDN inhibits migration of several cancer cell lines expressing Tgase-2 via suppression of Tgase-2 expression and inhibition of Tgase-2 activity.	cardamonin	14-17	transglutaminase 2	Homo sapiens	104-111
23201552-12	2013	The finding that CDN has Tgase-2 inhibitory activity will give us a new scaffold or clue of pharmacophore for the development of more effective Tgase-2 inhibitors.	cardamonin	17-20	transglutaminase 2	Homo sapiens	25-32
23201552-12	2013	The finding that CDN has Tgase-2 inhibitory activity will give us a new scaffold or clue of pharmacophore for the development of more effective Tgase-2 inhibitors.	cardamonin	17-20	transglutaminase 2	Homo sapiens	144-151
23538439-5	2013	In addition, cardamonin suppressed the expression of cyclin D1 and c-myc, which are known beta-catenin/T cell factor (TCF)-dependent genes.	cardamonin	13-23	cyclin D1	Homo sapiens	53-62
23538439-5	2013	In addition, cardamonin suppressed the expression of cyclin D1 and c-myc, which are known beta-catenin/T cell factor (TCF)-dependent genes.	cardamonin	13-23	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	67-72
23538439-5	2013	In addition, cardamonin suppressed the expression of cyclin D1 and c-myc, which are known beta-catenin/T cell factor (TCF)-dependent genes.	cardamonin	13-23	catenin beta 1	Homo sapiens	90-102
23538439-5	2013	In addition, cardamonin suppressed the expression of cyclin D1 and c-myc, which are known beta-catenin/T cell factor (TCF)-dependent genes.	cardamonin	13-23	hepatocyte nuclear factor 4 alpha	Homo sapiens	118-121
21784080-0	2011	Cardamonin suppresses nitric oxide production via blocking the IFN-gamma/STAT pathway in endotoxin-challenged peritoneal macrophages of ICR mice.	cardamonin	0-10	interferon gamma	Mus musculus	63-72
22696397-3	2012	Cardamonin (30 and 100 mg/kg) significantly elevated the survival rate of septic mice, alleviated ALI and lung microvascular leak, and lowered the serum levels of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	cardamonin	0-10	tumor necrosis factor	Mus musculus	189-198
22696397-3	2012	Cardamonin (30 and 100 mg/kg) significantly elevated the survival rate of septic mice, alleviated ALI and lung microvascular leak, and lowered the serum levels of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	cardamonin	0-10	interleukin 1 beta	Mus musculus	200-208
22696397-3	2012	Cardamonin (30 and 100 mg/kg) significantly elevated the survival rate of septic mice, alleviated ALI and lung microvascular leak, and lowered the serum levels of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	cardamonin	0-10	interleukin 6	Mus musculus	214-218
16777230-3	2007	Cardamonin suppressed the production of NO and PGE2 in interferon-gamma (IFN-gamma)- and lipopolysaccharide (LPS)-induced RAW 264.7 cells.	cardamonin	0-10	interferon gamma	Mus musculus	55-71
19800318-4	2009	In addition, cardamonin promoted the degradation of intracellular beta-catenin that was accumulated by Wnt3a-conditioned medium (Wnt3a CM) or bromoindirubin-3"-oxime (BIO), a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, in HEK293 reporter cells and human normal melanocytes.	cardamonin	13-23	catenin beta 1	Homo sapiens	66-78
19800318-4	2009	In addition, cardamonin promoted the degradation of intracellular beta-catenin that was accumulated by Wnt3a-conditioned medium (Wnt3a CM) or bromoindirubin-3"-oxime (BIO), a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, in HEK293 reporter cells and human normal melanocytes.	cardamonin	13-23	Wnt family member 3A	Homo sapiens	103-108
19800318-4	2009	In addition, cardamonin promoted the degradation of intracellular beta-catenin that was accumulated by Wnt3a-conditioned medium (Wnt3a CM) or bromoindirubin-3"-oxime (BIO), a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, in HEK293 reporter cells and human normal melanocytes.	cardamonin	13-23	Wnt family member 3A	Homo sapiens	129-134
19800318-4	2009	In addition, cardamonin promoted the degradation of intracellular beta-catenin that was accumulated by Wnt3a-conditioned medium (Wnt3a CM) or bromoindirubin-3"-oxime (BIO), a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, in HEK293 reporter cells and human normal melanocytes.	cardamonin	13-23	glycogen synthase kinase 3 beta	Homo sapiens	175-205
19800318-4	2009	In addition, cardamonin promoted the degradation of intracellular beta-catenin that was accumulated by Wnt3a-conditioned medium (Wnt3a CM) or bromoindirubin-3"-oxime (BIO), a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, in HEK293 reporter cells and human normal melanocytes.	cardamonin	13-23	glycogen synthase kinase 3 beta	Homo sapiens	207-216
19682913-4	2009	Of the isolates, cardamomin (6), the most potent compound, enhanced the expressions of DR5 and DR4 and decreased the Bcl-xL level in TRAIL-resistant DLD1 cells.	cardamonin	17-27	TNF receptor superfamily member 10b	Homo sapiens	87-90
19682913-4	2009	Of the isolates, cardamomin (6), the most potent compound, enhanced the expressions of DR5 and DR4 and decreased the Bcl-xL level in TRAIL-resistant DLD1 cells.	cardamonin	17-27	major histocompatibility complex, class II, DR beta 4	Homo sapiens	95-98
19682913-4	2009	Of the isolates, cardamomin (6), the most potent compound, enhanced the expressions of DR5 and DR4 and decreased the Bcl-xL level in TRAIL-resistant DLD1 cells.	cardamonin	17-27	BCL2 like 1	Homo sapiens	117-123
19682913-4	2009	Of the isolates, cardamomin (6), the most potent compound, enhanced the expressions of DR5 and DR4 and decreased the Bcl-xL level in TRAIL-resistant DLD1 cells.	cardamonin	17-27	TNF superfamily member 10	Homo sapiens	133-138
19923439-0	2010	Cardamonin is a bifunctional vasodilator that inhibits Ca(v)1.2 current and stimulates K(Ca)1.1 current in rat tail artery myocytes.	cardamonin	0-10	gastrokine 1	Rattus norvegicus	87-95
19767764-8	2009	The Km and Vmax values for cardamonin hydroxylation were calculated as 32 micromol/L and 35 pmol x min(-1) x mg(-1), respectively.	cardamonin	27-37	CD59 molecule (CD59 blood group)	Homo sapiens	99-105
16777230-3	2007	Cardamonin suppressed the production of NO and PGE2 in interferon-gamma (IFN-gamma)- and lipopolysaccharide (LPS)-induced RAW 264.7 cells.	cardamonin	0-10	interferon gamma	Mus musculus	73-82
16650843-3	2006	Cardamonin inhibited NO and PGE(2) production from lipopolysaccharide- and interferon-gamma-induced RAW cells and whole blood with IC(50) values of 11.4 microM and 26.8 microM, respectively.	cardamonin	0-10	interferon gamma	Mus musculus	75-91
33234722-0	2020	Cardamonin induces G2/M phase arrest and apoptosis through inhibition of NF-kappaB and mTOR pathways in ovarian cancer.	cardamonin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	73-82
16183703-6	2006	LPS-induced production of TNF-alpha and NO as well as expression of inducible nitric-oxide synthase and cyclooxygenase-2 was significantly suppressed by the treatment of cardamomin in RAW264.7 cells.	cardamonin	170-180	tumor necrosis factor	Mus musculus	26-35
16183703-6	2006	LPS-induced production of TNF-alpha and NO as well as expression of inducible nitric-oxide synthase and cyclooxygenase-2 was significantly suppressed by the treatment of cardamomin in RAW264.7 cells.	cardamonin	170-180	prostaglandin-endoperoxide synthase 2	Mus musculus	104-120
16183703-7	2006	Also, cardamomin inhibited not only LPS-induced degradation and phosphorylation of inhibitor kappaBalpha (IkappaBalpha) but also activation of inhibitor kappaB (IkappaB) kinases and nuclear translocation of NF-kappaB.	cardamonin	6-16	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	106-118
16183703-8	2006	Further analyses revealed that cardamomin did not directly inhibit IkappaB kinases, but it significantly suppressed LPS-induced activation of Akt.	cardamonin	31-41	thymoma viral proto-oncogene 1	Mus musculus	142-145
16183703-9	2006	Moreover, cardamomin suppressed transcriptional activity and phosphorylation of Ser536 of RelA/p65 subunit of NF-kappaB.	cardamonin	10-20	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	90-94
16183703-11	2006	We also demonstrated that pretreatment of cardamomin rescued C57BL/6 mice from LPS-induced mortality in conjunction with decreased serum level of TNF-alpha.	cardamonin	42-52	tumor necrosis factor	Mus musculus	146-155
33237524-5	2021	Out of the three best selected natural products, cardamomin showed excellently predicted drug-like properties, superior pharmacological profile, and specific interactions with MAO-B active site, indicating a potential selectivity over MAO-B.	cardamonin	49-59	monoamine oxidase B	Homo sapiens	176-181
33237524-5	2021	Out of the three best selected natural products, cardamomin showed excellently predicted drug-like properties, superior pharmacological profile, and specific interactions with MAO-B active site, indicating a potential selectivity over MAO-B.	cardamonin	49-59	monoamine oxidase B	Homo sapiens	235-240
33234722-0	2020	Cardamonin induces G2/M phase arrest and apoptosis through inhibition of NF-kappaB and mTOR pathways in ovarian cancer.	cardamonin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	87-91
33234722-6	2020	Our results indicate that cardamonin suppresses cancer cell growth by inducing G2/M phase arrest and apoptosis through targeted inhibition of NF-kappaB and mTOR pathways.	cardamonin	26-36	nuclear factor kappa B subunit 1	Homo sapiens	142-151
33234722-6	2020	Our results indicate that cardamonin suppresses cancer cell growth by inducing G2/M phase arrest and apoptosis through targeted inhibition of NF-kappaB and mTOR pathways.	cardamonin	26-36	mechanistic target of rapamycin kinase	Homo sapiens	156-160
34766179-10	2021	CDM also repressed the activation of p-AKT, p-ERK1/2, and p-IkappaBalpha, and prevented the OM-induced nuclear transcription of NF-kappaB p65.	cardamonin	0-3	AKT serine/threonine kinase 1	Homo sapiens	39-42
34890758-8	2022	In addition, MMP-9 expression induced by PMA is also decreased by the down-stream metabolites of HO-1, indicating that HO-1 expression partially contributes to the anti-inflammatory effect exerted by cardamonin.	cardamonin	200-210	matrix metallopeptidase 9	Mus musculus	13-18
34890758-8	2022	In addition, MMP-9 expression induced by PMA is also decreased by the down-stream metabolites of HO-1, indicating that HO-1 expression partially contributes to the anti-inflammatory effect exerted by cardamonin.	cardamonin	200-210	heme oxygenase 1	Mus musculus	97-101
34890758-8	2022	In addition, MMP-9 expression induced by PMA is also decreased by the down-stream metabolites of HO-1, indicating that HO-1 expression partially contributes to the anti-inflammatory effect exerted by cardamonin.	cardamonin	200-210	heme oxygenase 1	Mus musculus	119-123
34890758-9	2022	In this study, cardamonin demonstrates anti-inflammatory and anti-oxidative effects on PMA-induced pulmonary inflammation and activating Nrf2/HO-1 axis in alveolar macrophages.	cardamonin	15-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
34890758-9	2022	In this study, cardamonin demonstrates anti-inflammatory and anti-oxidative effects on PMA-induced pulmonary inflammation and activating Nrf2/HO-1 axis in alveolar macrophages.	cardamonin	15-25	heme oxygenase 1	Mus musculus	142-146
34751899-0	2022	Cardamonin inhibits the expression of P-glycoprotein and enhances the anti-proliferation of paclitaxel on SKOV3-Taxol cells.	cardamonin	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	38-52
34751899-10	2022	Cardamonin restrained NF-kappaB activation in SKOV3-Taxol cells (P < 0.05).	cardamonin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	22-31
34751899-12	2022	Cardamonin significantly inhibited the upregulation of NF-kappaB p65 (nuclear protein) and P-gp expression induced by TNF-alpha (P < 0.05).	cardamonin	0-10	RELA proto-oncogene, NF-kB subunit	Homo sapiens	55-68
34751899-12	2022	Cardamonin significantly inhibited the upregulation of NF-kappaB p65 (nuclear protein) and P-gp expression induced by TNF-alpha (P < 0.05).	cardamonin	0-10	negative elongation factor complex member E	Homo sapiens	70-85
34751899-12	2022	Cardamonin significantly inhibited the upregulation of NF-kappaB p65 (nuclear protein) and P-gp expression induced by TNF-alpha (P < 0.05).	cardamonin	0-10	phosphoglycolate phosphatase	Homo sapiens	91-95
34751899-12	2022	Cardamonin significantly inhibited the upregulation of NF-kappaB p65 (nuclear protein) and P-gp expression induced by TNF-alpha (P < 0.05).	cardamonin	0-10	tumor necrosis factor	Homo sapiens	118-127
34751899-14	2022	The mechanism might be involved in inhibition of P-gp efflux pump, reducing MDR1 mRNA and P-gp expression by cardamonin via suppression of NF-kappaB activation in SKOV3-Taxol cells.	cardamonin	109-119	phosphoglycolate phosphatase	Homo sapiens	49-53
34751899-14	2022	The mechanism might be involved in inhibition of P-gp efflux pump, reducing MDR1 mRNA and P-gp expression by cardamonin via suppression of NF-kappaB activation in SKOV3-Taxol cells.	cardamonin	109-119	ATP binding cassette subfamily B member 1	Homo sapiens	76-80
34751899-14	2022	The mechanism might be involved in inhibition of P-gp efflux pump, reducing MDR1 mRNA and P-gp expression by cardamonin via suppression of NF-kappaB activation in SKOV3-Taxol cells.	cardamonin	109-119	phosphoglycolate phosphatase	Homo sapiens	90-94
34751899-14	2022	The mechanism might be involved in inhibition of P-gp efflux pump, reducing MDR1 mRNA and P-gp expression by cardamonin via suppression of NF-kappaB activation in SKOV3-Taxol cells.	cardamonin	109-119	nuclear factor kappa B subunit 1	Homo sapiens	139-148
34638032-0	2021	Cardamonin inhibits LPS-induced inflammatory responses and prevents acute lung injury by targeting myeloid differentiation factor 2.	cardamonin	0-10	lymphocyte antigen 96	Mus musculus	99-131
34638032-5	2021	PCR array, SPR and ELISA were used to determine the potential target of the most active compound, Cardamonin (CAR).	cardamonin	98-108	sepiapterin reductase	Mus musculus	11-14
34638032-9	2021	In vivo, our data show that CAR treatment inhibited LPS-induced lung damage, systemic inflammatory cytokine production, and reduced macrophage infiltration in the lungs, accompanied with reduced TLR4/MD2 complex in lung tissues, Treatment with CAR also dose-dependently increased survival in the septic mice induced by DH5alpha bacterial infection.	cardamonin	244-247	toll-like receptor 4	Mus musculus	195-199
34638032-9	2021	In vivo, our data show that CAR treatment inhibited LPS-induced lung damage, systemic inflammatory cytokine production, and reduced macrophage infiltration in the lungs, accompanied with reduced TLR4/MD2 complex in lung tissues, Treatment with CAR also dose-dependently increased survival in the septic mice induced by DH5alpha bacterial infection.	cardamonin	244-247	lymphocyte antigen 96	Mus musculus	200-203
34766179-10	2021	CDM also repressed the activation of p-AKT, p-ERK1/2, and p-IkappaBalpha, and prevented the OM-induced nuclear transcription of NF-kappaB p65.	cardamonin	0-3	mitogen-activated protein kinase 3	Homo sapiens	46-52
34766179-10	2021	CDM also repressed the activation of p-AKT, p-ERK1/2, and p-IkappaBalpha, and prevented the OM-induced nuclear transcription of NF-kappaB p65.	cardamonin	0-3	NFKB inhibitor alpha	Homo sapiens	60-72
34766179-10	2021	CDM also repressed the activation of p-AKT, p-ERK1/2, and p-IkappaBalpha, and prevented the OM-induced nuclear transcription of NF-kappaB p65.	cardamonin	0-3	RELA proto-oncogene, NF-kB subunit	Homo sapiens	128-141
34690788-4	2021	The interaction between cardamonin and dTCTP was confirmed by SPR assay.	cardamonin	24-34	Translationally controlled tumor protein	Drosophila melanogaster	39-44
34608744-6	2021	Cardamonin achieved a significant inhibition of the apyrase activity and the three-dimensional structure of the potato apyrase, obtained by homology modeling, showed that cardamonin may interact mainly through hydrogen bonds.	cardamonin	0-10	apyrase	Solanum tuberosum	52-59
34608744-6	2021	Cardamonin achieved a significant inhibition of the apyrase activity and the three-dimensional structure of the potato apyrase, obtained by homology modeling, showed that cardamonin may interact mainly through hydrogen bonds.	cardamonin	0-10	apyrase	Solanum tuberosum	119-126
34608744-6	2021	Cardamonin achieved a significant inhibition of the apyrase activity and the three-dimensional structure of the potato apyrase, obtained by homology modeling, showed that cardamonin may interact mainly through hydrogen bonds.	cardamonin	171-181	apyrase	Solanum tuberosum	52-59
34608744-6	2021	Cardamonin achieved a significant inhibition of the apyrase activity and the three-dimensional structure of the potato apyrase, obtained by homology modeling, showed that cardamonin may interact mainly through hydrogen bonds.	cardamonin	171-181	apyrase	Solanum tuberosum	119-126
34608744-7	2021	Molecular docking studies corroborate with the action of cardamonin in binding and inhibiting both potato apyrase and S. mansoni NTPDases.	cardamonin	57-67	apyrase	Solanum tuberosum	106-113
34690788-6	2021	This interaction between dTCTP and cardamonin was confirmed through kinetic analysis (KD = 4.72 +- 0.07 muM).	cardamonin	35-45	Translationally controlled tumor protein	Drosophila melanogaster	25-30
34690788-8	2021	In addition, cardamonin was observed to have an anti-allergic response by inhibiting the activity of NF-kappaB.	cardamonin	13-23	nuclear factor kappa B subunit 1	Homo sapiens	101-110
34690788-9	2021	Cardamonin exerts anti-allergic anti-inflammatory effect by inhibiting dTCTP, suggesting that it may be useful in the therapy of allergic diseases.	cardamonin	0-10	Translationally controlled tumor protein	Drosophila melanogaster	71-76
34684383-0	2021	Inhibitory Effect of Tangeretin and Cardamonin on Human Intestinal SGLT1 Activity In Vitro and Blood Glucose Levels in Mice In Vivo.	cardamonin	36-46	solute carrier family 5 member 1	Homo sapiens	67-72
34684383-5	2021	Among the 50 phytochemicals assessed, tangeretin and cardamonin inhibited SGLT1 activity.	cardamonin	53-63	solute carrier family 5 member 1	Homo sapiens	74-79
35219163-0	2022	Cardamomin protects from diabetes-induced kidney damage through modulating PI3K/AKT and JAK/STAT signaling pathways in rats.	cardamonin	0-10	signal transducer and activator of transcription 3	Rattus norvegicus	92-96
34072123-8	2021	Our findings identify cardamonin as a candidate Nrf2 activator for the treatment and prevention of OA related to inflammation and oxidative stress.	cardamonin	22-32	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
35219163-0	2022	Cardamomin protects from diabetes-induced kidney damage through modulating PI3K/AKT and JAK/STAT signaling pathways in rats.	cardamonin	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
34577821-0	2021	Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation.	cardamonin	24-34	NLR family, pyrin domain containing 3	Mus musculus	98-103
34577821-9	2021	Cardamonin was also shown to attenuate the production of COX-2 in MSU-stimulated J774A.1 macrophage cells.	cardamonin	0-10	cytochrome c oxidase II, mitochondrial	Mus musculus	57-62
34577821-11	2021	Conclusions: Overall, cardamonin significantly attenuated IL-1beta secretion, caspase-1 activity, and COX-2 production stimulated by MSU.	cardamonin	22-32	interleukin 1 alpha	Rattus norvegicus	58-66
34577821-11	2021	Conclusions: Overall, cardamonin significantly attenuated IL-1beta secretion, caspase-1 activity, and COX-2 production stimulated by MSU.	cardamonin	22-32	caspase 1	Rattus norvegicus	78-87
34577821-11	2021	Conclusions: Overall, cardamonin significantly attenuated IL-1beta secretion, caspase-1 activity, and COX-2 production stimulated by MSU.	cardamonin	22-32	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	102-107
34187951-0	2021	Cardamonin exerts a protective effect against autophagy and apoptosis in the testicles of diabetic male rats through the expression of Nrf2 via p62-mediated Keap-1 degradation.	cardamonin	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	135-139
34187951-0	2021	Cardamonin exerts a protective effect against autophagy and apoptosis in the testicles of diabetic male rats through the expression of Nrf2 via p62-mediated Keap-1 degradation.	cardamonin	0-10	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	144-147
34187951-0	2021	Cardamonin exerts a protective effect against autophagy and apoptosis in the testicles of diabetic male rats through the expression of Nrf2 via p62-mediated Keap-1 degradation.	cardamonin	0-10	Kelch-like ECH-associated protein 1	Rattus norvegicus	157-163
35142404-11	2022	Cardamonin increased OGD/R-induced activation of the HIF-1alpha/VEGFA pathway.	cardamonin	0-10	hypoxia inducible factor 1, alpha subunit	Mus musculus	53-63
35142404-11	2022	Cardamonin increased OGD/R-induced activation of the HIF-1alpha/VEGFA pathway.	cardamonin	0-10	vascular endothelial growth factor A	Mus musculus	64-69
35142404-12	2022	Inhibition of the HIF-1alpha/VEGFA signaling using inhibitor relieved the effect of cardamonin on cell viability, permeability and apoptosis in HBMECs under OGD/R.	cardamonin	84-94	hypoxia inducible factor 1, alpha subunit	Mus musculus	18-28
35142404-12	2022	Inhibition of the HIF-1alpha/VEGFA signaling using inhibitor relieved the effect of cardamonin on cell viability, permeability and apoptosis in HBMECs under OGD/R.	cardamonin	84-94	vascular endothelial growth factor A	Mus musculus	29-34
35142404-13	2022	Cardamonin mitigated brain injury and promoted activation of the HIF-1alpha/VEGFA signaling in MCAO-treated mice.	cardamonin	0-10	hypoxia inducible factor 1, alpha subunit	Mus musculus	65-75
35142404-13	2022	Cardamonin mitigated brain injury and promoted activation of the HIF-1alpha/VEGFA signaling in MCAO-treated mice.	cardamonin	0-10	vascular endothelial growth factor A	Mus musculus	76-81
35142404-14	2022	Overall, cardamonin protected against OGD/R-induced HBMEC damage and MACO-induced brain injury through activating the HIF-1alpha/VEGFA pathway.	cardamonin	9-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-128
35142404-14	2022	Overall, cardamonin protected against OGD/R-induced HBMEC damage and MACO-induced brain injury through activating the HIF-1alpha/VEGFA pathway.	cardamonin	9-19	vascular endothelial growth factor A	Mus musculus	129-134