PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25200870-8 2014 Treatment with a PKC inhibitor bisindolylmaleimide (BIM) I prior to PMA treatment blocked the inhibitory effect of PMA, indicating PKC activation is essential for downregulating OATP1B3 activity. bisindolylmaleimide 31-50 solute carrier organic anion transporter family member 1B3 Homo sapiens 178-185 25200870-8 2014 Treatment with a PKC inhibitor bisindolylmaleimide (BIM) I prior to PMA treatment blocked the inhibitory effect of PMA, indicating PKC activation is essential for downregulating OATP1B3 activity. bisindolylmaleimide 52-55 solute carrier organic anion transporter family member 1B3 Homo sapiens 178-185 24682423-7 2014 Using the bisindolylmaleimide Ro-31-8220 as an inhibitor and ingenol as an activator of the conventional PKC isoforms, we were able to show that the Kv1.5/Kvbeta1.2 ion channel complex is mainly regulated by conventional isoforms. bisindolylmaleimide 10-29 potassium voltage-gated channel subfamily A member 5 Homo sapiens 149-154 24136992-4 2014 Pharmacological analysis using staurosporine-like indolocarbazole and bisindolylmaleimide compounds suggested that the phorbol ester- and receptor agonist-induced activation of NHE1 occurs through a protein kinase C-independent mechanism. bisindolylmaleimide 70-89 solute carrier family 9 member A1 Homo sapiens 177-181 23562764-8 2013 RESULTS: The general PKC inhibitors Go 6983 and bisindolylmaleimide but not cPKC inhibitor Go 6976 led to substantial PKCeta downregulation, which was partly rescued by the introduction of nPKCepsilon. bisindolylmaleimide 48-67 protein kinase C epsilon Homo sapiens 21-24 23684008-10 2013 Pre-treatment of the system with Akt inhibitor IV, Bisindolylmaleimide (PKC inhibitor) and src inhibitor I resulted in a significant decrease of the GLP-1 induced angiogenesis. bisindolylmaleimide 51-70 proline rich transmembrane protein 2 Homo sapiens 72-75 23684008-10 2013 Pre-treatment of the system with Akt inhibitor IV, Bisindolylmaleimide (PKC inhibitor) and src inhibitor I resulted in a significant decrease of the GLP-1 induced angiogenesis. bisindolylmaleimide 51-70 glucagon like peptide 1 receptor Homo sapiens 149-154 21559963-1 2012 Binding of several bisindolylmaleimide (BIS) like (BIS-3, BIS-8 and UCN1) and other ligands (H89, SB203580 and Y27632) with the glycogen synthase kinase-3 (GSK-3beta) has been studied using combined docking, molecular dynamics and Poisson-Boltzmann surface area analysis approaches. bisindolylmaleimide 19-38 glycogen synthase kinase 3 beta Homo sapiens 156-165 23296142-9 2013 Insertion of ERalpha was blocked by the ER antagonist ICI 182,780 or with the protein kinase C (PKC) pathway inhibitor bisindolylmaleimide (BIS). bisindolylmaleimide 119-138 estrogen receptor 1 (alpha) Mus musculus 13-20 23296142-9 2013 Insertion of ERalpha was blocked by the ER antagonist ICI 182,780 or with the protein kinase C (PKC) pathway inhibitor bisindolylmaleimide (BIS). bisindolylmaleimide 140-143 estrogen receptor 1 (alpha) Mus musculus 13-20 22798207-7 2012 The mechanisms behind this effect seem to be dependent on protein kinase C (PKC), since inhibition of PKC using bisindolylmaleimide XI, could also sensitize these cells to TRAIL through a similar effect on caspase-3 activation. bisindolylmaleimide 112-131 TNF superfamily member 10 Homo sapiens 172-177 22798207-7 2012 The mechanisms behind this effect seem to be dependent on protein kinase C (PKC), since inhibition of PKC using bisindolylmaleimide XI, could also sensitize these cells to TRAIL through a similar effect on caspase-3 activation. bisindolylmaleimide 112-131 caspase 3 Homo sapiens 206-215 22798207-8 2012 Moreover, TRAIL co-treatment with bisindolylmaleimide XI or curcumin resulted in down-regulation of X-linked inhibitor of apoptosis protein. bisindolylmaleimide 34-53 TNF superfamily member 10 Homo sapiens 10-15 21559963-1 2012 Binding of several bisindolylmaleimide (BIS) like (BIS-3, BIS-8 and UCN1) and other ligands (H89, SB203580 and Y27632) with the glycogen synthase kinase-3 (GSK-3beta) has been studied using combined docking, molecular dynamics and Poisson-Boltzmann surface area analysis approaches. bisindolylmaleimide 40-43 glycogen synthase kinase 3 beta Homo sapiens 156-165 21975875-6 2012 Broad PKC inhibitors (PMA, bisindolylmaleimide, Go6976), as well as specific PKCbeta blockade with an inhibitor and small interfering RNA (siRNA), prevented RhoA activation by glucose. bisindolylmaleimide 27-46 ras homolog family member A Rattus norvegicus 157-161 21787730-8 2011 Through the use of the protein kinase C inhibitor bisindolylmaleimide (VIII) acetate we have demonstrated the involvement PKC in the Nrf2-mediated response of 1321N1 cells to 5-10 muM Cd. bisindolylmaleimide 50-69 cytochrome c oxidase subunit 8A Homo sapiens 71-75 21842414-6 2011 On the other hand, TPA-induced phosphorylation of integrin signaling components including focal adhesion kinase (FAK), Src (Tyr416) and paxillin (Tyr31 and Ser178) can be prevented by PKC inhibitor Bisindolylmaleimides (BIS) and antioxidant dithiotheritol (DTT). bisindolylmaleimide 198-218 protein tyrosine kinase 2 Homo sapiens 90-111 21842414-6 2011 On the other hand, TPA-induced phosphorylation of integrin signaling components including focal adhesion kinase (FAK), Src (Tyr416) and paxillin (Tyr31 and Ser178) can be prevented by PKC inhibitor Bisindolylmaleimides (BIS) and antioxidant dithiotheritol (DTT). bisindolylmaleimide 198-218 protein tyrosine kinase 2 Homo sapiens 113-116 21842414-6 2011 On the other hand, TPA-induced phosphorylation of integrin signaling components including focal adhesion kinase (FAK), Src (Tyr416) and paxillin (Tyr31 and Ser178) can be prevented by PKC inhibitor Bisindolylmaleimides (BIS) and antioxidant dithiotheritol (DTT). bisindolylmaleimide 220-223 protein tyrosine kinase 2 Homo sapiens 90-111 21842414-6 2011 On the other hand, TPA-induced phosphorylation of integrin signaling components including focal adhesion kinase (FAK), Src (Tyr416) and paxillin (Tyr31 and Ser178) can be prevented by PKC inhibitor Bisindolylmaleimides (BIS) and antioxidant dithiotheritol (DTT). bisindolylmaleimide 220-223 protein tyrosine kinase 2 Homo sapiens 113-116 21715334-5 2011 Consistent with results using pure proteins, treatment of cells with the competitive inhibitors Go 6983 or bisindolylmaleimide I, but not the uncompetitive inhibitor bisindolylmaleimide IV, prevents the dephosphorylation and down-regulation of PKC induced by phorbol esters. bisindolylmaleimide 107-126 proline rich transmembrane protein 2 Homo sapiens 244-247 21521715-7 2011 The SN-induced ERK activation was significantly blocked by pharmacological inhibition of MAPK kinase (MEK) with PD-98059 and protein kinase C (PKC) with bisindolylmaleimide. bisindolylmaleimide 153-172 mitogen-activated protein kinase 1 Mus musculus 15-18 21787730-8 2011 Through the use of the protein kinase C inhibitor bisindolylmaleimide (VIII) acetate we have demonstrated the involvement PKC in the Nrf2-mediated response of 1321N1 cells to 5-10 muM Cd. bisindolylmaleimide 50-69 protein kinase C delta Homo sapiens 122-125 21787730-8 2011 Through the use of the protein kinase C inhibitor bisindolylmaleimide (VIII) acetate we have demonstrated the involvement PKC in the Nrf2-mediated response of 1321N1 cells to 5-10 muM Cd. bisindolylmaleimide 50-69 NFE2 like bZIP transcription factor 2 Homo sapiens 133-137 21120453-7 2011 In HEK cells heterologously expressing hERG channels, chelerythrine and bisindolylmaleimide I blocked hERG current in a concentration-dependent manner, having EC(50) values of 0.11 +- 0.01 and 0.76 +- 0.04 muM, respectively. bisindolylmaleimide 72-91 ETS transcription factor ERG Homo sapiens 39-43 21120453-7 2011 In HEK cells heterologously expressing hERG channels, chelerythrine and bisindolylmaleimide I blocked hERG current in a concentration-dependent manner, having EC(50) values of 0.11 +- 0.01 and 0.76 +- 0.04 muM, respectively. bisindolylmaleimide 72-91 ETS transcription factor ERG Homo sapiens 102-106 21120453-7 2011 In HEK cells heterologously expressing hERG channels, chelerythrine and bisindolylmaleimide I blocked hERG current in a concentration-dependent manner, having EC(50) values of 0.11 +- 0.01 and 0.76 +- 0.04 muM, respectively. bisindolylmaleimide 72-91 latexin Homo sapiens 206-209 20466804-11 2010 In addition, the amount of connexin43 showed significant increase after addition of bisindolylmaleimide, implicating that protein kinase C is a relevant target in endothelin-1-mediated connexin43 expression. bisindolylmaleimide 84-103 gap junction protein, alpha 1 Rattus norvegicus 27-37 22043317-5 2011 In contrast, an uncompetitive substrate inhibitor, bisindolylmaleimide IV, targets quiescent PKC and stabilizes PKC in the quiescent conformation, which generates slower activation and suppressed translocation upon activation of PKC. bisindolylmaleimide 51-70 proline rich transmembrane protein 2 Homo sapiens 93-96 22043317-5 2011 In contrast, an uncompetitive substrate inhibitor, bisindolylmaleimide IV, targets quiescent PKC and stabilizes PKC in the quiescent conformation, which generates slower activation and suppressed translocation upon activation of PKC. bisindolylmaleimide 51-70 proline rich transmembrane protein 2 Homo sapiens 112-115 22043317-5 2011 In contrast, an uncompetitive substrate inhibitor, bisindolylmaleimide IV, targets quiescent PKC and stabilizes PKC in the quiescent conformation, which generates slower activation and suppressed translocation upon activation of PKC. bisindolylmaleimide 51-70 proline rich transmembrane protein 2 Homo sapiens 112-115 20543084-8 2010 The treatment of isolated rat ventricular myocytes with sildenafil or 8-bromo-cGMP (PKG agonist) enhanced PLM Ser69 phosphorylation, which was bisindolylmaleimide (PKC inhibitor) sensitive. bisindolylmaleimide 143-162 FXYD domain-containing ion transport regulator 1 Rattus norvegicus 106-109 20466804-11 2010 In addition, the amount of connexin43 showed significant increase after addition of bisindolylmaleimide, implicating that protein kinase C is a relevant target in endothelin-1-mediated connexin43 expression. bisindolylmaleimide 84-103 endothelin 1 Rattus norvegicus 163-175 20466804-11 2010 In addition, the amount of connexin43 showed significant increase after addition of bisindolylmaleimide, implicating that protein kinase C is a relevant target in endothelin-1-mediated connexin43 expression. bisindolylmaleimide 84-103 gap junction protein, alpha 1 Rattus norvegicus 185-195 19631644-8 2009 The effect of SP or NKA on K(+) currents in CAPS-responsive phasic neurons was fully reversed by an NK(2) receptor antagonist (MEN10376) but only partially reversed by a PKC inhibitor (bisindolylmaleimide). bisindolylmaleimide 185-204 Natural killer alloreactivity QTL 1 Rattus norvegicus 20-23 19915095-5 2010 This action of orexin A was blocked by SB334867, an orexin receptor 1 (OXR1) blocker and bisindolylmaleimide, a protein kinase C (PKC) inhibitor, indicating the involvement of OXR1 and PKC. bisindolylmaleimide 89-108 hypocretin Mus musculus 15-23 19776392-6 2010 Reduced vimentin phosphorylation, cell spreading, and beta1 integrin surface expression, and activation were phenocopied in cells treated with the protein kinase C inhibitor bisindolylmaleimide; cell spreading was also reduced by siRNA knockdown of protein kinase C-epsilon. bisindolylmaleimide 174-193 vimentin Homo sapiens 8-16 19776392-6 2010 Reduced vimentin phosphorylation, cell spreading, and beta1 integrin surface expression, and activation were phenocopied in cells treated with the protein kinase C inhibitor bisindolylmaleimide; cell spreading was also reduced by siRNA knockdown of protein kinase C-epsilon. bisindolylmaleimide 174-193 integrin subunit beta 1 Homo sapiens 54-68 19776392-6 2010 Reduced vimentin phosphorylation, cell spreading, and beta1 integrin surface expression, and activation were phenocopied in cells treated with the protein kinase C inhibitor bisindolylmaleimide; cell spreading was also reduced by siRNA knockdown of protein kinase C-epsilon. bisindolylmaleimide 174-193 protein kinase C epsilon Homo sapiens 249-273 19537828-10 2009 Using this approach, we captured the known Bisindolylmaleimide-III target GSK3-beta and previously unidentified targets from live cells. bisindolylmaleimide 43-62 glycogen synthase kinase 3 beta Homo sapiens 74-83 19190238-6 2009 Immunoblot analysis showed a PAR(2)-induced increase in cPLA(2) phosphorylation that was blocked by the mitogen-activated protein kinase kinase inhibitor, PD98059 [2-(2-amino-3methoxyphenyl)-4H-1benzopyran-4-one, C(16)H(13)NO(3)], and the pan-protein kinase C inhibitor, GFX (bisindolylmaleimide). bisindolylmaleimide 276-295 nuclear receptor subfamily 1 group I member 2 Homo sapiens 29-32 19527072-8 2009 Phosphorylation was inhibited with a PKC inhibitor, bisindolylmaleimide. bisindolylmaleimide 52-71 protein kinase C, alpha Rattus norvegicus 37-40 19327373-5 2009 Inhibition of classical and novel PKC isoforms by treatment with bisindolylmaleimide or PKC down-regulation by long-term treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) could not prevent apoptosis induced by palmitate or stearate. bisindolylmaleimide 65-84 proline rich transmembrane protein 2 Homo sapiens 34-37 19190238-6 2009 Immunoblot analysis showed a PAR(2)-induced increase in cPLA(2) phosphorylation that was blocked by the mitogen-activated protein kinase kinase inhibitor, PD98059 [2-(2-amino-3methoxyphenyl)-4H-1benzopyran-4-one, C(16)H(13)NO(3)], and the pan-protein kinase C inhibitor, GFX (bisindolylmaleimide). bisindolylmaleimide 276-295 phospholipase A2 group IVA Homo sapiens 56-63 19028699-8 2009 Additionally, both protein kinase C and phosphatidylinositol 3-kinase are presumably involved in insulin-induced ROS generation because bisindolylmaleimide, a nonspecific protein kinase C inhibitor, and LY290042, an inhibitor of phosphatidylinositol 3-kinase, inhibited this increase. bisindolylmaleimide 136-155 insulin Homo sapiens 97-104 19208258-7 2009 In TRPV4 expressing HEK 293T cells, PDBu increased 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD)-induced single-channel activity in cell-attached patches, which was abrogated by bisindolylmaleimide (BIM), a selective PKC inhibitor. bisindolylmaleimide 179-198 transient receptor potential cation channel subfamily V member 4 Homo sapiens 3-8 18774710-0 2008 Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta. bisindolylmaleimide 34-53 protein kinase C alpha Homo sapiens 85-107 19171302-0 2009 Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides. bisindolylmaleimide 102-122 glycogen synthase kinase 3 beta Mus musculus 15-20 19171302-4 2009 We synthesized a series of bisindolylmaleimides, a subset of which inhibit GSK-3 in murine ESCs and robustly enhance self-renewal in the presence of leukemia inhibitory factor (LIF) and serum, but not in the absence of LIF. bisindolylmaleimide 27-47 glycogen synthase kinase 3 beta Mus musculus 75-80 19171302-4 2009 We synthesized a series of bisindolylmaleimides, a subset of which inhibit GSK-3 in murine ESCs and robustly enhance self-renewal in the presence of leukemia inhibitory factor (LIF) and serum, but not in the absence of LIF. bisindolylmaleimide 27-47 leukemia inhibitory factor Mus musculus 149-175 19171302-4 2009 We synthesized a series of bisindolylmaleimides, a subset of which inhibit GSK-3 in murine ESCs and robustly enhance self-renewal in the presence of leukemia inhibitory factor (LIF) and serum, but not in the absence of LIF. bisindolylmaleimide 27-47 leukemia inhibitory factor Mus musculus 177-180 19171302-4 2009 We synthesized a series of bisindolylmaleimides, a subset of which inhibit GSK-3 in murine ESCs and robustly enhance self-renewal in the presence of leukemia inhibitory factor (LIF) and serum, but not in the absence of LIF. bisindolylmaleimide 27-47 leukemia inhibitory factor Mus musculus 219-222 18456322-6 2008 Ba(2+) influx was reduced by 30-40% when cells were treated with either a PKC inhibitor (Go 6983, bisindolylmaleimide) or the PKC activator phorbol-12-myristate-13-acetate. bisindolylmaleimide 98-117 protein kinase C, alpha Rattus norvegicus 74-77 18774710-1 2008 The synthesis and biochemical characterization of AX4697, a fluorescent, bisindolylmaleimide-derived probe for PKCalpha and beta, is described. bisindolylmaleimide 73-92 protein kinase C alpha Homo sapiens 111-128 18977550-3 2008 Ruboxistaurin mesylate is a bisindolylmaleimide that specifically inhibits the beta isoform of protein kinase C (PKC). bisindolylmaleimide 28-47 protein kinase C beta Homo sapiens 113-116 18598261-8 2008 Facilitatory effects of SP, NKA and PDBu were reversed by bisindolylmaleimide, a PKC inhibitor, and gradually decreased in magnitude when the agents were administered at increasing intervals after CAPS application. bisindolylmaleimide 58-77 Natural killer alloreactivity QTL 1 Rattus norvegicus 28-31 19013297-10 2008 Bisindolylmaleimide, a PKC inhibitor, significantly inhibited d-glucose-induced transactivation of PON1; and mithramycin, an inhibitor of Sp1, completely abrogated the transactivation. bisindolylmaleimide 0-19 paraoxonase 1 Homo sapiens 99-103 18462865-2 2008 Enzastaurin (LY317615), an acyclic bisindolylmaleimide, is an oral inhibitor of PKCbeta as well as other isoforms. bisindolylmaleimide 35-54 protein kinase C beta Homo sapiens 80-87 18237278-4 2008 Initial contraction and MLC(20) (20 kDa regulatory light chain of myosin II) phosphorylation induced by LPA were abolished by inhibitors of PLC (phospholipase C)-beta (U73122) or MLCK (myosin light-chain kinase; ML-9), but were not affected by inhibitors of PKC (bisindolylmaleimide) or Rho kinase (Y27632). bisindolylmaleimide 263-282 myosin light chain 12B Homo sapiens 24-31 18237278-5 2008 In contrast, sustained contraction, and phosphorylation of MLC(20) and CPI-17 (PKC-potentiated inhibitor 17 kDa protein) induced by LPA were abolished selectively by bisindolylmaleimide. bisindolylmaleimide 166-185 myosin light chain 12B Homo sapiens 59-66 18237278-5 2008 In contrast, sustained contraction, and phosphorylation of MLC(20) and CPI-17 (PKC-potentiated inhibitor 17 kDa protein) induced by LPA were abolished selectively by bisindolylmaleimide. bisindolylmaleimide 166-185 protein phosphatase 1 regulatory inhibitor subunit 14A Homo sapiens 71-77 17986385-5 2008 On the other hand, the effect on TACE was shown to be dependent on protein kinase C, since it was completely blocked in the presence of the inhibitor bisindolylmaleimide XI. bisindolylmaleimide 150-169 ADAM metallopeptidase domain 17 Homo sapiens 33-37 18434353-6 2008 The protein kinase C (PKC) inhibitors Ro-31-8425 and bisindolylmaleimide I attenuated the potentiating effect of AVP on CRH-stimulated insulin secretion and blocked AVP-stimulated insulin secretion. bisindolylmaleimide 53-72 arginine vasopressin Mus musculus 113-116 18434353-6 2008 The protein kinase C (PKC) inhibitors Ro-31-8425 and bisindolylmaleimide I attenuated the potentiating effect of AVP on CRH-stimulated insulin secretion and blocked AVP-stimulated insulin secretion. bisindolylmaleimide 53-72 corticotropin releasing hormone Mus musculus 120-123 18434353-6 2008 The protein kinase C (PKC) inhibitors Ro-31-8425 and bisindolylmaleimide I attenuated the potentiating effect of AVP on CRH-stimulated insulin secretion and blocked AVP-stimulated insulin secretion. bisindolylmaleimide 53-72 arginine vasopressin Mus musculus 165-168 18372238-6 2008 The PMA-mediated decrease of LXR activity was blocked by the PKC inhibitor bisindolylmaleimide and mimicked by constitutively active PKCalpha. bisindolylmaleimide 75-94 protein kinase C alpha Homo sapiens 61-64 18354023-6 2008 This potentiation was blocked by SB 334867, a selective HCRT receptor (Hcrtr 1) antagonist, or bisindolylmaleimide, a specific protein kinase C (PKC) inhibitor, indicating the involvement of Hcrtr 1 and PKC. bisindolylmaleimide 95-114 hypocretin receptor 1 Homo sapiens 191-198 18635421-3 2008 The review presents bisindolylmaleimide-mediated PKC-dependent and PKC-independent biological effects, such as reversal of MDR and modulation of Wnt signaling through GSK-3b and b-catenin. bisindolylmaleimide 20-39 proline rich transmembrane protein 2 Homo sapiens 49-52 18635421-3 2008 The review presents bisindolylmaleimide-mediated PKC-dependent and PKC-independent biological effects, such as reversal of MDR and modulation of Wnt signaling through GSK-3b and b-catenin. bisindolylmaleimide 20-39 proline rich transmembrane protein 2 Homo sapiens 67-70 18635421-3 2008 The review presents bisindolylmaleimide-mediated PKC-dependent and PKC-independent biological effects, such as reversal of MDR and modulation of Wnt signaling through GSK-3b and b-catenin. bisindolylmaleimide 20-39 glycogen synthase kinase 3 beta Homo sapiens 167-173 18635421-3 2008 The review presents bisindolylmaleimide-mediated PKC-dependent and PKC-independent biological effects, such as reversal of MDR and modulation of Wnt signaling through GSK-3b and b-catenin. bisindolylmaleimide 20-39 catenin beta 1 Homo sapiens 178-187 18025234-5 2007 Activation of PKD1 was inhibited by the combined PKD1 and protein kinase C (PKC) inhibitor Go 6976 but not by broad-spectrum PKC inhibitors, including bisindolylmaleimide (Bim) I. Pam(3)CSK(4) and SCF also induced phosphorylation of heat shock protein 27, a known substrate of PKD1, which was also inhibited by Go 6976 but not Bim I in BMMC. bisindolylmaleimide 172-175 polycystin 1, transient receptor potential channel interacting Mus musculus 14-18 17559070-7 2008 The hypoxia-induced changes in MMP-9 and TIMP-1 were inhibited by staurosporine and bisindolylmaleimide, inhibitors of protein kinase C (PKC), but not by inhibitors of tyrosine phosphorylation and the mitogen-activated protein kinase pathway. bisindolylmaleimide 84-103 matrix metallopeptidase 9 Homo sapiens 31-36 17559070-7 2008 The hypoxia-induced changes in MMP-9 and TIMP-1 were inhibited by staurosporine and bisindolylmaleimide, inhibitors of protein kinase C (PKC), but not by inhibitors of tyrosine phosphorylation and the mitogen-activated protein kinase pathway. bisindolylmaleimide 84-103 TIMP metallopeptidase inhibitor 1 Homo sapiens 41-47 18176092-8 2008 LTD(4)-induced MUC2 gene transcriptional activity was also suppressed by a G-protein inhibitor (pertussis toxin),a protein kinase C (PKC) inhibitor (bisindolylmaleimide), a mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitor (PD98059), an extracellular signal regulated kinase-2 (ERK-2) inhibitor (AG126) and a nuclear factor kappaB (NF-kappaB) inhibitor. bisindolylmaleimide 149-168 mucin 2, oligomeric mucus/gel-forming Homo sapiens 15-19 17888513-11 2007 Bisindolylmaleimide was able to block the effects of A1254 on GDNF secretion. bisindolylmaleimide 0-19 glial cell derived neurotrophic factor Homo sapiens 62-66 18066098-2 2007 Here, we demonstrate the protective effects of a novel bisindolylmaleimide derivative, MS1 (2-[1-(3-aminopropyl)indol-3-yl]-3-(indol-3-yl)-N-methylmaleimide), against reperfusion injury of the heart. bisindolylmaleimide 55-74 actin-binding Rho activating protein Rattus norvegicus 87-90 17589342-2 2007 Here we demonstrate the protective effects of a novel bisindolylmaleimide derivative, MS1, on enhancing the functional recovery of the heart following long-term hypothermic preservation when added to the preservative solution. bisindolylmaleimide 54-73 MS Homo sapiens 86-89 17373912-1 2007 ATP-competitive inhibitors of PKC (protein kinase C) such as the bisindolylmaleimide GF 109203X, which interact with the ATP-binding site in the PKC molecule, have also been shown to affect several redistribution events of PKC. bisindolylmaleimide 65-84 protein kinase C alpha Homo sapiens 30-33 17373912-1 2007 ATP-competitive inhibitors of PKC (protein kinase C) such as the bisindolylmaleimide GF 109203X, which interact with the ATP-binding site in the PKC molecule, have also been shown to affect several redistribution events of PKC. bisindolylmaleimide 65-84 protein kinase C alpha Homo sapiens 145-148 17373912-1 2007 ATP-competitive inhibitors of PKC (protein kinase C) such as the bisindolylmaleimide GF 109203X, which interact with the ATP-binding site in the PKC molecule, have also been shown to affect several redistribution events of PKC. bisindolylmaleimide 65-84 protein kinase C alpha Homo sapiens 145-148 17337596-6 2007 Treatment of FGF2 Tg and nontransgenic (NTg) hearts with the PKC inhibitor bisindolylmaleimide (1 micromol/l) revealed the necessity of PKC signaling for FGF2-induced reduction of contractile dysfunction and myocardial infarct size following ischemia-reperfusion injury. bisindolylmaleimide 75-94 fibroblast growth factor 2 Homo sapiens 13-17 17337596-6 2007 Treatment of FGF2 Tg and nontransgenic (NTg) hearts with the PKC inhibitor bisindolylmaleimide (1 micromol/l) revealed the necessity of PKC signaling for FGF2-induced reduction of contractile dysfunction and myocardial infarct size following ischemia-reperfusion injury. bisindolylmaleimide 75-94 protein kinase C alpha Homo sapiens 61-64 17337596-6 2007 Treatment of FGF2 Tg and nontransgenic (NTg) hearts with the PKC inhibitor bisindolylmaleimide (1 micromol/l) revealed the necessity of PKC signaling for FGF2-induced reduction of contractile dysfunction and myocardial infarct size following ischemia-reperfusion injury. bisindolylmaleimide 75-94 protein kinase C alpha Homo sapiens 136-139 17337596-6 2007 Treatment of FGF2 Tg and nontransgenic (NTg) hearts with the PKC inhibitor bisindolylmaleimide (1 micromol/l) revealed the necessity of PKC signaling for FGF2-induced reduction of contractile dysfunction and myocardial infarct size following ischemia-reperfusion injury. bisindolylmaleimide 75-94 fibroblast growth factor 2 Homo sapiens 154-158 17341442-11 2007 IGF-I stimulated PKC activation in the cells and pretreatment with PKC inhibitor bisindolylmaleimide prevented IGF-I-induced COX-2 transcriptional activation and mRNA stabilization, and inhibited COX-2 mRNA and protein expression. bisindolylmaleimide 81-100 insulin like growth factor 1 Homo sapiens 0-5 17341442-11 2007 IGF-I stimulated PKC activation in the cells and pretreatment with PKC inhibitor bisindolylmaleimide prevented IGF-I-induced COX-2 transcriptional activation and mRNA stabilization, and inhibited COX-2 mRNA and protein expression. bisindolylmaleimide 81-100 proline rich transmembrane protein 2 Homo sapiens 17-20 17341442-11 2007 IGF-I stimulated PKC activation in the cells and pretreatment with PKC inhibitor bisindolylmaleimide prevented IGF-I-induced COX-2 transcriptional activation and mRNA stabilization, and inhibited COX-2 mRNA and protein expression. bisindolylmaleimide 81-100 proline rich transmembrane protein 2 Homo sapiens 67-70 17341442-11 2007 IGF-I stimulated PKC activation in the cells and pretreatment with PKC inhibitor bisindolylmaleimide prevented IGF-I-induced COX-2 transcriptional activation and mRNA stabilization, and inhibited COX-2 mRNA and protein expression. bisindolylmaleimide 81-100 insulin like growth factor 1 Homo sapiens 111-116 17341442-11 2007 IGF-I stimulated PKC activation in the cells and pretreatment with PKC inhibitor bisindolylmaleimide prevented IGF-I-induced COX-2 transcriptional activation and mRNA stabilization, and inhibited COX-2 mRNA and protein expression. bisindolylmaleimide 81-100 prostaglandin-endoperoxide synthase 2 Homo sapiens 125-130 17341442-11 2007 IGF-I stimulated PKC activation in the cells and pretreatment with PKC inhibitor bisindolylmaleimide prevented IGF-I-induced COX-2 transcriptional activation and mRNA stabilization, and inhibited COX-2 mRNA and protein expression. bisindolylmaleimide 81-100 prostaglandin-endoperoxide synthase 2 Homo sapiens 196-201 17482559-8 2007 Finally, the reduction in Rfc1 activity caused by PB, TCPOBOP and PMA was reversed by simultaneous incubation with the specific PKC inhibitor bisindolylmaleimide (BIM; 21 ng/ml). bisindolylmaleimide 142-161 replication factor C subunit 1 Rattus norvegicus 26-30 17482559-8 2007 Finally, the reduction in Rfc1 activity caused by PB, TCPOBOP and PMA was reversed by simultaneous incubation with the specific PKC inhibitor bisindolylmaleimide (BIM; 21 ng/ml). bisindolylmaleimide 163-166 replication factor C subunit 1 Rattus norvegicus 26-30 17363391-9 2007 The PKC inhibitor bisindolylmaleimide (BIM) abolished PDBu-mediated potentiation of TRPV1-dependent increases in mEPSC frequency, suggesting modulation of TRPV1 by PKC-induced phosphorylation. bisindolylmaleimide 18-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 17363391-9 2007 The PKC inhibitor bisindolylmaleimide (BIM) abolished PDBu-mediated potentiation of TRPV1-dependent increases in mEPSC frequency, suggesting modulation of TRPV1 by PKC-induced phosphorylation. bisindolylmaleimide 18-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 155-160 17363391-9 2007 The PKC inhibitor bisindolylmaleimide (BIM) abolished PDBu-mediated potentiation of TRPV1-dependent increases in mEPSC frequency, suggesting modulation of TRPV1 by PKC-induced phosphorylation. bisindolylmaleimide 39-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 17363391-9 2007 The PKC inhibitor bisindolylmaleimide (BIM) abolished PDBu-mediated potentiation of TRPV1-dependent increases in mEPSC frequency, suggesting modulation of TRPV1 by PKC-induced phosphorylation. bisindolylmaleimide 39-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 155-160 17575116-0 2007 Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure. bisindolylmaleimide 75-94 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 14-19 17575116-2 2007 In an effort to identify novel inhibitors of ABCG2, we examined the ability of commercially available bisindolylmaleimides (BIM) and indolocarbazole protein kinase inhibitors (PKI) to inhibit ABCG2, given the previous demonstration that the indolocarbazole PKI UCN-01 interacted with the transporter. bisindolylmaleimide 102-122 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 192-197 17575116-2 2007 In an effort to identify novel inhibitors of ABCG2, we examined the ability of commercially available bisindolylmaleimides (BIM) and indolocarbazole protein kinase inhibitors (PKI) to inhibit ABCG2, given the previous demonstration that the indolocarbazole PKI UCN-01 interacted with the transporter. bisindolylmaleimide 124-127 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 192-197 17146445-11 2007 Pretreatment of U-1242-PKC-eta cells with inhibitors of PKC or MAPK/ERK kinase (MEK) (bisindolyl maleimide (BIM) or U0126, respectively) blocked both PMA-induced Elk-1 transcriptional activity and PMA-stimulated proliferation. bisindolylmaleimide 86-106 protein kinase C eta Homo sapiens 23-26 17146445-11 2007 Pretreatment of U-1242-PKC-eta cells with inhibitors of PKC or MAPK/ERK kinase (MEK) (bisindolyl maleimide (BIM) or U0126, respectively) blocked both PMA-induced Elk-1 transcriptional activity and PMA-stimulated proliferation. bisindolylmaleimide 86-106 mitogen-activated protein kinase 1 Homo sapiens 68-71 17146445-11 2007 Pretreatment of U-1242-PKC-eta cells with inhibitors of PKC or MAPK/ERK kinase (MEK) (bisindolyl maleimide (BIM) or U0126, respectively) blocked both PMA-induced Elk-1 transcriptional activity and PMA-stimulated proliferation. bisindolylmaleimide 86-106 ETS transcription factor ELK1 Homo sapiens 162-167 17146445-11 2007 Pretreatment of U-1242-PKC-eta cells with inhibitors of PKC or MAPK/ERK kinase (MEK) (bisindolyl maleimide (BIM) or U0126, respectively) blocked both PMA-induced Elk-1 transcriptional activity and PMA-stimulated proliferation. bisindolylmaleimide 108-111 ETS transcription factor ELK1 Homo sapiens 162-167 17446238-4 2007 Pharmacological inhibition of the phosphatidylinositol-3 (PI-3) kinase by LY294002, mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK)1/2 by U0126, the protein kinase (PK) A pathway by H-89 or KT5720, and the PKC pathway by bisindolylmaleimide suppressed IGF-I-stimulated cell proliferation. bisindolylmaleimide 255-274 mitogen-activated protein kinase 3 Homo sapiens 156-160 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. bisindolylmaleimide 129-148 protein kinase C alpha Homo sapiens 111-114 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. bisindolylmaleimide 129-148 cyclin dependent kinase 20 Homo sapiens 169-172 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. bisindolylmaleimide 129-148 mitogen-activated protein kinase 1 Homo sapiens 176-179 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. bisindolylmaleimide 129-148 interleukin 6 Homo sapiens 200-204 17185372-5 2007 The GnRH effect was Ca(2+) independent, mimicked by the phorbol ester phorbol 12-myristate 13-acetate, and blocked by the protein kinase C (PKC) inhibitor bisindolylmaleimide, indicating that the GnRH effect was mediated by PKC. bisindolylmaleimide 155-174 protein kinase C, delta Mus musculus 140-143 17185372-5 2007 The GnRH effect was Ca(2+) independent, mimicked by the phorbol ester phorbol 12-myristate 13-acetate, and blocked by the protein kinase C (PKC) inhibitor bisindolylmaleimide, indicating that the GnRH effect was mediated by PKC. bisindolylmaleimide 155-174 protein kinase C, delta Mus musculus 224-227 17140607-3 2007 The PKC inhibitor bisindolylmaleimide Ro-31-8425 (Ro-31-8425, 0.5microM) decreased the peak Nav 1.8 current. bisindolylmaleimide 18-37 sodium voltage-gated channel alpha subunit 10 Rattus norvegicus 92-99 17031848-6 2007 This increased activity of Runx2 is almost completely inhibited by PKC inhibitors Bisindolylmaleimide and Rottlerin, and only minimally inhibited by PKA inihibitor H-89. bisindolylmaleimide 82-101 runt related transcription factor 2 Mus musculus 27-32 17027144-5 2007 Bisindolylmaleimide partially inhibited the CRF-mediated increase in CREB phosphorylation, but only in AtT-20 cells, suggesting that the protein kinase C pathway is involved in regulation of CREB phosphorylation via CRF1 receptor but not CRF2 receptor. bisindolylmaleimide 0-19 cAMP responsive element binding protein 1 Mus musculus 69-73 17027144-5 2007 Bisindolylmaleimide partially inhibited the CRF-mediated increase in CREB phosphorylation, but only in AtT-20 cells, suggesting that the protein kinase C pathway is involved in regulation of CREB phosphorylation via CRF1 receptor but not CRF2 receptor. bisindolylmaleimide 0-19 cAMP responsive element binding protein 1 Mus musculus 191-195 17027144-5 2007 Bisindolylmaleimide partially inhibited the CRF-mediated increase in CREB phosphorylation, but only in AtT-20 cells, suggesting that the protein kinase C pathway is involved in regulation of CREB phosphorylation via CRF1 receptor but not CRF2 receptor. bisindolylmaleimide 0-19 corticotropin releasing hormone receptor 1 Mus musculus 216-229 17027144-5 2007 Bisindolylmaleimide partially inhibited the CRF-mediated increase in CREB phosphorylation, but only in AtT-20 cells, suggesting that the protein kinase C pathway is involved in regulation of CREB phosphorylation via CRF1 receptor but not CRF2 receptor. bisindolylmaleimide 0-19 corticotropin releasing hormone receptor 2 Mus musculus 238-251 17027144-7 2007 Bisindolylmaleimide partially inhibited the UCN-mediated decrease in ERK phosphorylation in A7r5 cells, suggesting that the protein kinase C pathway is partially involved in CRF2 receptor signal transduction. bisindolylmaleimide 0-19 urocortin Rattus norvegicus 44-47 17027144-7 2007 Bisindolylmaleimide partially inhibited the UCN-mediated decrease in ERK phosphorylation in A7r5 cells, suggesting that the protein kinase C pathway is partially involved in CRF2 receptor signal transduction. bisindolylmaleimide 0-19 Eph receptor B1 Rattus norvegicus 69-72 17027144-7 2007 Bisindolylmaleimide partially inhibited the UCN-mediated decrease in ERK phosphorylation in A7r5 cells, suggesting that the protein kinase C pathway is partially involved in CRF2 receptor signal transduction. bisindolylmaleimide 0-19 corticotropin releasing hormone receptor 2 Rattus norvegicus 174-178 17200207-4 2007 The activation of protein kinase C (PKC) increased both MMP-9 activity and expression, which were blocked by some PKC inhibitors (Go6976, bisindolylmaleimide, and Rottlerin), PKC-alpha, and PKC-delta small interfering (si)RNAs but not by hispidin (PKC-beta inhibitor). bisindolylmaleimide 138-157 protein kinase C alpha Homo sapiens 36-39 17200207-4 2007 The activation of protein kinase C (PKC) increased both MMP-9 activity and expression, which were blocked by some PKC inhibitors (Go6976, bisindolylmaleimide, and Rottlerin), PKC-alpha, and PKC-delta small interfering (si)RNAs but not by hispidin (PKC-beta inhibitor). bisindolylmaleimide 138-157 matrix metallopeptidase 9 Homo sapiens 56-61 17200207-4 2007 The activation of protein kinase C (PKC) increased both MMP-9 activity and expression, which were blocked by some PKC inhibitors (Go6976, bisindolylmaleimide, and Rottlerin), PKC-alpha, and PKC-delta small interfering (si)RNAs but not by hispidin (PKC-beta inhibitor). bisindolylmaleimide 138-157 protein kinase C alpha Homo sapiens 114-117 16987961-8 2006 In contrast, treatment by bisindolylmaleimide, Go6976, and rottlerin, and chronic application of phorbol 12-myristate 13-acetate and/or bryostatin-1 indicated that PKC delta mediated PEA-15 inhibition of astrocyte migration. bisindolylmaleimide 26-45 protein kinase C, delta Mus musculus 164-173 17472415-1 2007 Ruboxistaurin, an orally active protein kinase C beta (PKC beta) inhibitor, is a macrocyclic bisindolylmaleimide compound under development by Eli Lilly with potential as a therapy for diabetic macular oedema and other diabetic angiopathies, including diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. bisindolylmaleimide 93-112 protein kinase C beta Homo sapiens 55-63 17172978-6 2007 Nonspecific PKC inhibition (bisindolylmaleimide) significantly attenuated hypoxic pulmonary vasoconstriction (44.59 +/- 10.52% vs. 87.06 +/- 10.91% vehicle; P < 0.001) and downregulated hypoxia-induced expression of pulmonary artery TNF-alpha. bisindolylmaleimide 28-47 tumor necrosis factor Rattus norvegicus 236-245 16887872-8 2006 Spaced application of 5-HT activated protein kinase C (PKC) as evidenced by increased phosphorylations of PKC at Thr(514) and myristoylated alanine-rich C kinase substrate (MARCKS) and these effects were abolished by ketanserin as well as bisindolylmaleimide (Bis-1), an inhibitor of PKC. bisindolylmaleimide 239-258 myristoylated alanine rich protein kinase C substrate Mus musculus 173-179 16623718-5 2006 Experiments with bisindolylmaleimide I and IX indicated the requirement of PKC activity. bisindolylmaleimide 17-36 protein kinase C zeta Homo sapiens 75-78 16872362-6 2006 This G(2)-phase arrest was reversed by pre-treatment with bisindolylmaleimide or U0126, which are selective inhibitors of protein kinase C proteins or the extracellular signal-regulated kinase activators, MEK1/2, respectively. bisindolylmaleimide 58-77 mitogen-activated protein kinase 1 Homo sapiens 155-192 16872362-6 2006 This G(2)-phase arrest was reversed by pre-treatment with bisindolylmaleimide or U0126, which are selective inhibitors of protein kinase C proteins or the extracellular signal-regulated kinase activators, MEK1/2, respectively. bisindolylmaleimide 58-77 mitogen-activated protein kinase kinase 1 Homo sapiens 205-211 16815434-8 2006 The PKC inhibitor, bis-indolylmaleimide (500 nM) largely blocked the acute influence of the most potent dose (10(-9) M) on contractile function. bisindolylmaleimide 19-39 protein kinase C, gamma Rattus norvegicus 4-7 16461926-3 2006 The PKC inhibitor bisindolylmaleimide 1 (Bis) inhibited Ang II-induced p44/42 MAPK phosphorylation whereas the cPKC inhibitor Go6976 failed to do so, thus ruling out the participation of PKCalpha. bisindolylmaleimide 18-37 angiotensinogen Homo sapiens 56-62 16183668-10 2006 Protein kinase C inhibitor bisindolylmaleimide and the protein tyrosine kinase inhibitor genistein partially reversed ceramide inhibition, indicating that protein kinases play important roles in the ceramide inhibition of SP-B gene expression. bisindolylmaleimide 27-46 surfactant protein B Homo sapiens 222-226 16461926-3 2006 The PKC inhibitor bisindolylmaleimide 1 (Bis) inhibited Ang II-induced p44/42 MAPK phosphorylation whereas the cPKC inhibitor Go6976 failed to do so, thus ruling out the participation of PKCalpha. bisindolylmaleimide 18-37 interferon induced protein 44 Homo sapiens 71-74 16461926-3 2006 The PKC inhibitor bisindolylmaleimide 1 (Bis) inhibited Ang II-induced p44/42 MAPK phosphorylation whereas the cPKC inhibitor Go6976 failed to do so, thus ruling out the participation of PKCalpha. bisindolylmaleimide 18-37 mitogen-activated protein kinase 3 Homo sapiens 78-82 16197368-3 2006 In the present paper, we show that, in human platelets, VASP is phosphorylated by PKC on Ser157, but not Ser239, in response to phorbol ester stimulation, in a manner blocked by the PKC inhibitor BIM I (bisindolylmaleimide I). bisindolylmaleimide 203-222 vasodilator stimulated phosphoprotein Homo sapiens 56-60 16302800-3 2005 We determined the structures of PIM-1 in complex with bisindolylmaleimide (BIM-1) and established the structure-activity relationship (SAR) for this inhibitor class. bisindolylmaleimide 54-73 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 32-37 16302800-3 2005 We determined the structures of PIM-1 in complex with bisindolylmaleimide (BIM-1) and established the structure-activity relationship (SAR) for this inhibitor class. bisindolylmaleimide 54-73 sarcosine dehydrogenase Homo sapiens 102-139 16248886-5 2005 The inhibition of PKC by bis-indolylmaleimide mimicked and enhanced betaE2-induced neuroprotection. bisindolylmaleimide 25-45 protein kinase C, epsilon Mus musculus 18-21 16075446-1 2005 The bisindolylmaleimides are selective protein kinase inhibitors that can adopt two limiting diastereomeric (syn and anti) conformations. bisindolylmaleimide 4-24 synemin Homo sapiens 109-112 16075446-5 2005 The rate of interconversion of the syn and anti conformers varied by over twenty orders of magnitude through substitution of a bisindolylmaleimide ring system, which was constrained within a macrocyclic ring. bisindolylmaleimide 127-146 synemin Homo sapiens 35-38 15976015-3 2005 The TPA-induced increase of p21 in PANC-1 cells was blocked by bisindolylmaleimide or rottlerin (inhibitors of protein kinase C). bisindolylmaleimide 63-82 H3 histone pseudogene 16 Homo sapiens 28-31 15976015-3 2005 The TPA-induced increase of p21 in PANC-1 cells was blocked by bisindolylmaleimide or rottlerin (inhibitors of protein kinase C). bisindolylmaleimide 63-82 pancreas protein 1 Mus musculus 35-41 15980059-4 2005 Inhibition of PI 3-K, mTOR with rapamycin, or PKC with bisindolylmaleimide ameliorated the AA-mediated down-regulation of CYP2E1 mRNA expression. bisindolylmaleimide 55-74 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 122-128 16039614-3 2005 PKC activator PDBu induced ERK1/2 phosphorylation which was inhibited by general PKC inhibitor bisindolylmaleimide and Go 6983 as well as the MEK inhibitor U0126 but not by the PKCdelta inhibitor rottlerin. bisindolylmaleimide 95-114 protein kinase C delta Homo sapiens 0-3 16039614-3 2005 PKC activator PDBu induced ERK1/2 phosphorylation which was inhibited by general PKC inhibitor bisindolylmaleimide and Go 6983 as well as the MEK inhibitor U0126 but not by the PKCdelta inhibitor rottlerin. bisindolylmaleimide 95-114 mitogen-activated protein kinase 3 Homo sapiens 27-33 16039614-3 2005 PKC activator PDBu induced ERK1/2 phosphorylation which was inhibited by general PKC inhibitor bisindolylmaleimide and Go 6983 as well as the MEK inhibitor U0126 but not by the PKCdelta inhibitor rottlerin. bisindolylmaleimide 95-114 protein kinase C delta Homo sapiens 81-84 15920195-3 2005 A PKC inhibitor, bisindolylmaleimide, abolished the induction of IKATP by a second brief isoflurane exposure under these conditions. bisindolylmaleimide 17-36 Prkca Cavia porcellus 2-5 15946695-8 2005 Protein kinase C (PKC) inhibitors, staurosporine, bisindolylmaleimide I, and H-7 also blocked ANG II-induced stimulation of 2-DG uptake. bisindolylmaleimide 50-69 angiogenin, ribonuclease, RNase A family, 5 Mus musculus 94-97 16006563-4 2005 In HEK 293 cells co-expressing TREK-1 and either the thyrotropin-releasing hormone receptor (TRHR1) or the Orexin receptor (Orx1R), agonist stimulation induced robust channel inhibition that was suppressed by a bisindolylmaleimide PKC inhibitor but not by a protein kinase A blocker ((R(p))-cAMP-S). bisindolylmaleimide 211-230 potassium two pore domain channel subfamily K member 2 Homo sapiens 31-37 16006563-4 2005 In HEK 293 cells co-expressing TREK-1 and either the thyrotropin-releasing hormone receptor (TRHR1) or the Orexin receptor (Orx1R), agonist stimulation induced robust channel inhibition that was suppressed by a bisindolylmaleimide PKC inhibitor but not by a protein kinase A blocker ((R(p))-cAMP-S). bisindolylmaleimide 211-230 thyrotropin releasing hormone receptor Homo sapiens 53-91 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 173-193 protein kinase C alpha Homo sapiens 87-95 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 173-193 protein kinase C beta Homo sapiens 97-104 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 173-193 ribosomal protein S6 kinase A5 Homo sapiens 106-110 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 173-193 ribosomal protein S6 kinase B1 Homo sapiens 112-119 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 173-193 pyruvate dehydrogenase kinase 1 Homo sapiens 121-126 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 173-193 ribosomal protein S6 kinase A1 Homo sapiens 132-146 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 173-193 glycogen synthase kinase 3 beta Homo sapiens 279-287 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 173-193 synemin Homo sapiens 368-371 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 313-333 protein kinase C alpha Homo sapiens 87-95 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 313-333 protein kinase C beta Homo sapiens 97-104 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 313-333 ribosomal protein S6 kinase A5 Homo sapiens 106-110 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 313-333 ribosomal protein S6 kinase B1 Homo sapiens 112-119 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 313-333 pyruvate dehydrogenase kinase 1 Homo sapiens 121-126 16104747-4 2005 This approach lead to the conclusion that several AGC group protein kinases (including PKCalpha, PKCbeta, MSK1, p70 S6K, PDK-1, and MAPKAP-K1alpha) may be best inhibited by bisindolylmaleimides which adopt a compressed approximately C2-symmetric anti conformation; in constrast, GSK3beta may be best inhibited by bisindolylmaleimides whose ground state is a distorted syn conformation. bisindolylmaleimide 313-333 ribosomal protein S6 kinase A1 Homo sapiens 132-146 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). bisindolylmaleimide 112-131 mitogen-activated protein kinase kinase 7 Homo sapiens 11-54 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). bisindolylmaleimide 112-131 mitogen-activated protein kinase kinase 7 Homo sapiens 56-59 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). bisindolylmaleimide 112-131 interleukin 6 Homo sapiens 182-186 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). bisindolylmaleimide 112-115 mitogen-activated protein kinase kinase 7 Homo sapiens 11-54 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). bisindolylmaleimide 112-115 mitogen-activated protein kinase kinase 7 Homo sapiens 56-59 16046706-7 2005 Disrupting mitogen-activated protein kinase/Erk kinase (MEK) and protein kinase C (PKC) activity with U0126 and Bisindolylmaleimide (Bis), respectively, suppressed palmitate-induced IL-6 expression (P < 0.05), but had no effect on NF-kappaB reporter gene activity (P > 0.05). bisindolylmaleimide 112-115 interleukin 6 Homo sapiens 182-186 15821757-1 2005 1 Bisindolylmaleimide inhibitors of protein kinase C (PKC), such as GF109203X and Ro31-8220, have been used to investigate the roles of PKC isoforms in many cellular processes in cardiac myocytes, but these agents may also inhibit p90RSK activity. bisindolylmaleimide 2-21 protein kinase C, alpha Rattus norvegicus 54-57 15821757-1 2005 1 Bisindolylmaleimide inhibitors of protein kinase C (PKC), such as GF109203X and Ro31-8220, have been used to investigate the roles of PKC isoforms in many cellular processes in cardiac myocytes, but these agents may also inhibit p90RSK activity. bisindolylmaleimide 2-21 protein kinase C, alpha Rattus norvegicus 136-139 15820207-9 2005 Importantly, inhibition of ET-1 constriction by Bis occurred in 24 months but not 4 months (p<0.01). bisindolylmaleimide 48-51 endothelin 1 Rattus norvegicus 27-31 15664665-6 2005 The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone. bisindolylmaleimide 37-56 kininogen 1 Homo sapiens 111-113 15664665-6 2005 The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone. bisindolylmaleimide 37-56 interleukin 1 beta Homo sapiens 117-125 15664665-6 2005 The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone. bisindolylmaleimide 37-56 tumor necrosis factor Homo sapiens 130-138 15664665-6 2005 The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone. bisindolylmaleimide 37-56 C-X-C motif chemokine ligand 8 Homo sapiens 149-153 15780848-9 2005 Inhibition of kinases upstream to MEK1/2 (PI-3K, PKC, and CaMKII) by administration of LY294002, bisindolylmaleimide, or KN-62, respectively, also reversed clozapine-induced suppression of CAR. bisindolylmaleimide 97-116 mitogen activated protein kinase kinase 1 Rattus norvegicus 34-40 15780848-9 2005 Inhibition of kinases upstream to MEK1/2 (PI-3K, PKC, and CaMKII) by administration of LY294002, bisindolylmaleimide, or KN-62, respectively, also reversed clozapine-induced suppression of CAR. bisindolylmaleimide 97-116 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Rattus norvegicus 42-64 15780848-9 2005 Inhibition of kinases upstream to MEK1/2 (PI-3K, PKC, and CaMKII) by administration of LY294002, bisindolylmaleimide, or KN-62, respectively, also reversed clozapine-induced suppression of CAR. bisindolylmaleimide 97-116 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 189-192 15618223-5 2005 PMA-induced phosphorylation of the EGFR at Tyr(1068) was blocked by bisindolylmaleimide (BIM), a PKC inhibitor, and rottlerin, a PKCdelta-specific inhibitor. bisindolylmaleimide 68-87 epidermal growth factor receptor Homo sapiens 35-39 15618223-5 2005 PMA-induced phosphorylation of the EGFR at Tyr(1068) was blocked by bisindolylmaleimide (BIM), a PKC inhibitor, and rottlerin, a PKCdelta-specific inhibitor. bisindolylmaleimide 68-87 protein kinase C delta Homo sapiens 97-100 15618223-5 2005 PMA-induced phosphorylation of the EGFR at Tyr(1068) was blocked by bisindolylmaleimide (BIM), a PKC inhibitor, and rottlerin, a PKCdelta-specific inhibitor. bisindolylmaleimide 89-92 epidermal growth factor receptor Homo sapiens 35-39 15618223-5 2005 PMA-induced phosphorylation of the EGFR at Tyr(1068) was blocked by bisindolylmaleimide (BIM), a PKC inhibitor, and rottlerin, a PKCdelta-specific inhibitor. bisindolylmaleimide 89-92 protein kinase C delta Homo sapiens 97-100 15531633-7 2005 This is confirmed by experimental evidence suggesting that the recycling of the CXCR4 receptor is increased on stimulation with phorbol ester and blocked on inhibition of PKC by bisindolylmaleimide. bisindolylmaleimide 178-197 C-X-C motif chemokine receptor 4 Homo sapiens 80-85 15531633-7 2005 This is confirmed by experimental evidence suggesting that the recycling of the CXCR4 receptor is increased on stimulation with phorbol ester and blocked on inhibition of PKC by bisindolylmaleimide. bisindolylmaleimide 178-197 protein kinase C alpha Homo sapiens 171-174 15591586-6 2005 The initial Ca(2+)-dependent contraction and myosin light-chain (MLC)(20) phosphorylation were inhibited by the PLC inhibitor U-73122 and the MLC kinase inhibitor ML-9 but were not affected by the Rho kinase inhibitor Y27632 or the PKC inhibitor bisindolylmaleimide. bisindolylmaleimide 246-265 modulator of VRAC current 1 Homo sapiens 45-63 15917995-5 2005 Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner. bisindolylmaleimide 31-51 protein kinase C alpha Homo sapiens 69-72 15917995-5 2005 Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner. bisindolylmaleimide 31-51 mitogen-activated protein kinase 1 Homo sapiens 120-123 15917995-5 2005 Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner. bisindolylmaleimide 31-51 cyclin dependent kinase inhibitor 2B Homo sapiens 145-148 15917995-5 2005 Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner. bisindolylmaleimide 31-51 cyclin dependent kinase inhibitor 2B Homo sapiens 149-154 15917995-5 2005 Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner. bisindolylmaleimide 31-51 cyclin dependent kinase inhibitor 2A Homo sapiens 160-163 15917995-5 2005 Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner. bisindolylmaleimide 31-51 cyclin dependent kinase inhibitor 2A Homo sapiens 164-169 15591586-6 2005 The initial Ca(2+)-dependent contraction and myosin light-chain (MLC)(20) phosphorylation were inhibited by the PLC inhibitor U-73122 and the MLC kinase inhibitor ML-9 but were not affected by the Rho kinase inhibitor Y27632 or the PKC inhibitor bisindolylmaleimide. bisindolylmaleimide 246-265 myosin light chain 12B Homo sapiens 65-72 15591586-6 2005 The initial Ca(2+)-dependent contraction and myosin light-chain (MLC)(20) phosphorylation were inhibited by the PLC inhibitor U-73122 and the MLC kinase inhibitor ML-9 but were not affected by the Rho kinase inhibitor Y27632 or the PKC inhibitor bisindolylmaleimide. bisindolylmaleimide 246-265 modulator of VRAC current 1 Homo sapiens 65-68 15591586-9 2005 Sustained contraction and MLC(20) phosphorylation were partly inhibited by Y27632 and bisindolylmaleimide and abolished by a combination of both inhibitors. bisindolylmaleimide 86-105 modulator of VRAC current 1 Homo sapiens 26-29 15454113-6 2004 Bis-indolylmaleimide, an inhibitor of protein kinase C, partially blocked the up-regulation of CD83 and ERK phosphorylation induced by PA and TNF-alpha. bisindolylmaleimide 0-20 CD83 molecule Homo sapiens 95-99 15454113-6 2004 Bis-indolylmaleimide, an inhibitor of protein kinase C, partially blocked the up-regulation of CD83 and ERK phosphorylation induced by PA and TNF-alpha. bisindolylmaleimide 0-20 mitogen-activated protein kinase 1 Homo sapiens 104-107 15454113-6 2004 Bis-indolylmaleimide, an inhibitor of protein kinase C, partially blocked the up-regulation of CD83 and ERK phosphorylation induced by PA and TNF-alpha. bisindolylmaleimide 0-20 tumor necrosis factor Homo sapiens 142-151 15475516-9 2004 The resultant phosphorylation of CPI-17 was blocked by bisindolylmaleimide, providing direct confirmation that it was PKC dependent. bisindolylmaleimide 55-74 protein phosphatase 1 regulatory inhibitor subunit 14A Homo sapiens 33-39 15304500-7 2004 Cells were treated with the selective protein kinase C (PKC) inhibitor bisindolylmaleimide to determine the role of PKC in S6K activation. bisindolylmaleimide 71-90 proline rich transmembrane protein 2 Homo sapiens 56-59 15304500-8 2004 The Thr-421 and Ser-424 phosphorylation sites of S6K were specifically inhibited by bisindolylmaleimide, which also blocked integrin alpha2 expression, cell adhesion, and motility. bisindolylmaleimide 84-103 integrin subunit alpha 2 Homo sapiens 124-139 15502023-4 2004 The PKC inhibitors chelerythrine (1 and 5 microM) and bisindolylmaleimide (100 and 400 nM) strongly increased flavoprotein oxidation in a dose-dependent manner. bisindolylmaleimide 54-73 Prkca Cavia porcellus 4-7 15155260-4 2004 Inhibition of Akt [indirectly via phosphatidylinositol 3-kinase with LY-294002 or wortmannin] or PKC (with bisindolylmaleimide) reduced VEGF-induced hyperpermeability. bisindolylmaleimide 107-126 vascular endothelial growth factor A Homo sapiens 136-140 15155260-8 2004 Furthermore, immunofluorescence studies with human umbilical vein endothelial cells revealed that bisindolylmaleimide, PD-98059, and l-NMMA attenuate VEGF-induced reorganization of vascular endothelial cadherin. bisindolylmaleimide 98-117 vascular endothelial growth factor A Homo sapiens 150-154 15155260-8 2004 Furthermore, immunofluorescence studies with human umbilical vein endothelial cells revealed that bisindolylmaleimide, PD-98059, and l-NMMA attenuate VEGF-induced reorganization of vascular endothelial cadherin. bisindolylmaleimide 98-117 cadherin 5 Homo sapiens 181-210 15448520-7 2004 Pretreatment with a protein kinase C (PKC) inhibitor, bisindolylmaleimide reduced the propofol (4.1 +/- 1.0 microg/ml)-induced greater decreases in ESP0.08 and PVA0.08 after brief ischemic-reperfusion to 94 +/- 33% and 92 +/- 39% of prepropofol. bisindolylmaleimide 54-73 protein kinase C, epsilon Rattus norvegicus 38-41 14996950-9 2004 The effect of PKC activation on AC9 was reversed by the PKC inhibitor bisindolylmaleimide. bisindolylmaleimide 70-89 adenylate cyclase 9 Homo sapiens 32-35 15324351-5 2004 The production of MMP-1 and TIMP-1 stimulated by PMA was abolished by the PKC inhibitor bisindolylmaleimide. bisindolylmaleimide 88-107 matrix metallopeptidase 1 Homo sapiens 18-23 15324351-5 2004 The production of MMP-1 and TIMP-1 stimulated by PMA was abolished by the PKC inhibitor bisindolylmaleimide. bisindolylmaleimide 88-107 TIMP metallopeptidase inhibitor 1 Homo sapiens 28-34 15178807-11 2004 The selective PKC inhibitor, bisindolylmaleimide VIII, however, inhibited TPA-induced changes in morphology and ERK activation. bisindolylmaleimide 29-48 Eph receptor B1 Rattus norvegicus 112-115 15177934-8 2004 The effects of NT on EGFR/ERK/Akt activation and DNA synthesis were attenuated by PLC-inhibitor (U73122), PKC-inhibitors (bisindolylmaleimide, staurosporine, rottlerin), MEK inhibitor (U0126) and PI3 kinase inhibitors (wortmannin, LY 294002). bisindolylmaleimide 122-141 epidermal growth factor receptor Homo sapiens 21-25 15177934-8 2004 The effects of NT on EGFR/ERK/Akt activation and DNA synthesis were attenuated by PLC-inhibitor (U73122), PKC-inhibitors (bisindolylmaleimide, staurosporine, rottlerin), MEK inhibitor (U0126) and PI3 kinase inhibitors (wortmannin, LY 294002). bisindolylmaleimide 122-141 mitogen-activated protein kinase 1 Homo sapiens 26-29 15106017-9 2004 The subsequent addition of exogenous PK-C (mixture of isoenzymes) to the cell lysates restored telomerase activity if incubation of cells with BIM was up to 24 h. Using PK-C isoenzymes, it was established that atypical PK-Czeta, but not conventional Ca2+ -dependent PK-Calpha, PK-Cbeta or PK-Cgamma, is responsible for the reactivation of telomerase in BIM-treated cells. bisindolylmaleimide 143-146 proline rich transmembrane protein 2 Homo sapiens 37-41 15106017-9 2004 The subsequent addition of exogenous PK-C (mixture of isoenzymes) to the cell lysates restored telomerase activity if incubation of cells with BIM was up to 24 h. Using PK-C isoenzymes, it was established that atypical PK-Czeta, but not conventional Ca2+ -dependent PK-Calpha, PK-Cbeta or PK-Cgamma, is responsible for the reactivation of telomerase in BIM-treated cells. bisindolylmaleimide 353-356 proline rich transmembrane protein 2 Homo sapiens 37-41 15051799-9 2004 Bisindolylmaleimide, a generalized protein kinase C (PKC) inhibitor, and B581, a Ras farnesylation inhibitor, inhibited AA-mediated activation of Erk1/2 and p38 MAPK, suggesting a role for PKC and Ras in mediating such activation. bisindolylmaleimide 0-19 mitogen activated protein kinase 3 Rattus norvegicus 146-152 15075212-9 2004 In contrast, sustained contraction and MLC(20) phosphorylation were partially inhibited by a PKC or Rho kinase inhibitor (bisindolylmaleimide and Y-27632) and abolished by a combination of both inhibitors but not affected by U-73122 or ML-9. bisindolylmaleimide 122-141 myosin light chain 12B Homo sapiens 39-46 15274349-4 2004 On the contrary, cotreatment with the PKC inhibitor bisindolylmaleimide potentiated inhibition of cord formation. bisindolylmaleimide 52-71 proline rich transmembrane protein 2 Homo sapiens 38-41 14769951-1 2004 Bisindolylmaleimide compounds such as GF109203X are potent inhibitors of protein kinase C (PKC) activity. bisindolylmaleimide 0-19 protein kinase C alpha Homo sapiens 91-94 14769951-5 2004 Subsequent in vitro binding and activity assays confirmed the protein kinases Ste20-related kinase and cyclin-dependent kinase 2 (CDK2) and the non-protein kinases adenosine kinase and quinone reductase type 2 as novel targets of bisindolylmaleimide inhibitors. bisindolylmaleimide 230-249 STE20 like kinase Homo sapiens 78-98 14769951-5 2004 Subsequent in vitro binding and activity assays confirmed the protein kinases Ste20-related kinase and cyclin-dependent kinase 2 (CDK2) and the non-protein kinases adenosine kinase and quinone reductase type 2 as novel targets of bisindolylmaleimide inhibitors. bisindolylmaleimide 230-249 cyclin dependent kinase 2 Homo sapiens 103-128 14769951-5 2004 Subsequent in vitro binding and activity assays confirmed the protein kinases Ste20-related kinase and cyclin-dependent kinase 2 (CDK2) and the non-protein kinases adenosine kinase and quinone reductase type 2 as novel targets of bisindolylmaleimide inhibitors. bisindolylmaleimide 230-249 cyclin dependent kinase 2 Homo sapiens 130-134 14769951-6 2004 As observed specifically for CDK2, minor chemical variation of the ligand by immobilizing the closely related bisindolylmaleimides III, VIII, and X dramatically affected target binding. bisindolylmaleimide 110-130 cyclin dependent kinase 2 Homo sapiens 29-33 14592950-6 2004 Activation of protein kinase C (PKC) and ERK1/2 was required for the UCN II-induced activation of MLC(20), because treatment of myometrial cells with inhibitors of MAPK kinase 1 (U0126) and PKC (bisindolylmaleimide) inhibited the UCN II-induced phosphorylation of MLC(20). bisindolylmaleimide 195-214 mitogen-activated protein kinase 3 Homo sapiens 41-47 14592950-6 2004 Activation of protein kinase C (PKC) and ERK1/2 was required for the UCN II-induced activation of MLC(20), because treatment of myometrial cells with inhibitors of MAPK kinase 1 (U0126) and PKC (bisindolylmaleimide) inhibited the UCN II-induced phosphorylation of MLC(20). bisindolylmaleimide 195-214 urocortin 2 Homo sapiens 69-75 14592950-6 2004 Activation of protein kinase C (PKC) and ERK1/2 was required for the UCN II-induced activation of MLC(20), because treatment of myometrial cells with inhibitors of MAPK kinase 1 (U0126) and PKC (bisindolylmaleimide) inhibited the UCN II-induced phosphorylation of MLC(20). bisindolylmaleimide 195-214 myosin light chain 12B Homo sapiens 98-104 15005273-6 2004 Both the angiotensin type 1 (AT1) receptor antagonist (valsartan: 200 nmol/l) and the PKC inhibitor, bisindolylmaleimide (GFX: 10 micromol/l) reduced Ang II-induced KDR mRNA expression to almost the control level. bisindolylmaleimide 101-120 proline rich transmembrane protein 2 Homo sapiens 86-89 14962382-0 2004 Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1. bisindolylmaleimide 35-55 pyruvate dehydrogenase kinase 1 Homo sapiens 72-76 14962382-3 2004 Specificity analysis with a panel of 29 protein kinases reveals that these bisindolyl maleimide inhibitors also inhibit PDK1, a key kinase from the insulin signaling pathway, albeit in the lower microM range. bisindolylmaleimide 75-95 pyruvate dehydrogenase kinase 1 Homo sapiens 120-124 14962382-4 2004 To understand the molecular basis of inhibition, the PDK1 kinase domain was cocrystallized with these bisindolyl maleimide inhibitors. bisindolylmaleimide 102-122 pyruvate dehydrogenase kinase 1 Homo sapiens 53-57 14729098-7 2004 Applications of trains of pulses at 1 or 2 Hz lead to a progressive increase in the bisindolylmaleimide (I)-blockade, and the recovery from bisindolylmaleimide (I)-block at -80 mV exhibited a time constant of 577.2+/-52.7 ms. Bisindolylmaleimide (V), an inactive analogue of bisindolylmaleimide (I), similarly inhibited the Kv currents with an apparent K(d) value of 1.48+/-0.004 microM, but other PKC inhibitor chelerythrine little affected the Kv currents. bisindolylmaleimide 140-159 protein kinase C, gamma Rattus norvegicus 398-401 14729098-7 2004 Applications of trains of pulses at 1 or 2 Hz lead to a progressive increase in the bisindolylmaleimide (I)-blockade, and the recovery from bisindolylmaleimide (I)-block at -80 mV exhibited a time constant of 577.2+/-52.7 ms. Bisindolylmaleimide (V), an inactive analogue of bisindolylmaleimide (I), similarly inhibited the Kv currents with an apparent K(d) value of 1.48+/-0.004 microM, but other PKC inhibitor chelerythrine little affected the Kv currents. bisindolylmaleimide 140-159 protein kinase C, gamma Rattus norvegicus 398-401 15005273-6 2004 Both the angiotensin type 1 (AT1) receptor antagonist (valsartan: 200 nmol/l) and the PKC inhibitor, bisindolylmaleimide (GFX: 10 micromol/l) reduced Ang II-induced KDR mRNA expression to almost the control level. bisindolylmaleimide 101-120 angiotensinogen Homo sapiens 150-156 15005273-6 2004 Both the angiotensin type 1 (AT1) receptor antagonist (valsartan: 200 nmol/l) and the PKC inhibitor, bisindolylmaleimide (GFX: 10 micromol/l) reduced Ang II-induced KDR mRNA expression to almost the control level. bisindolylmaleimide 101-120 kinase insert domain receptor Homo sapiens 165-168 12897807-5 2003 The negative inotropic effects of PE were inhibited by bisindolylmaleimide (inhibitor of all PKC isoforms) but not by Go 6976 (inhibitor of Ca2+-dependent PKC). bisindolylmaleimide 55-74 protein kinase C, delta Mus musculus 93-96 12919931-7 2003 Importantly, inhibition of ET-1 and U-44619 constriction by Bis occurred in the DM but not CTL group (P < 0.05). bisindolylmaleimide 60-63 endothelin 1 Rattus norvegicus 27-31 14521590-9 2003 Thrombin-induced neoangiogenesis was also inhibited to baseline level by agents known to inhibit thrombin receptor signaling in other cells: G-coupled protein receptor inhibitor, pertussis toxin (40 pg per egg), protein kinase C inhibitor, bisindolylmaleimide (1 microm per egg), MAP kinase inhibitor, PD980598 (10 microm per egg) and PI3 kinase inhibitor, LY294002 (0.25 microm per egg). bisindolylmaleimide 240-259 coagulation factor II, thrombin Gallus gallus 0-8 12955673-4 2003 Ruboxistaurin (LY333531) mesylate is a bisindolylmaleimide that shows a high degree of specificity within the protein kinase C (PKC) gene family for inhibiting PKC beta isoforms. bisindolylmaleimide 39-58 protein kinase C, beta Rattus norvegicus 128-131 12955673-4 2003 Ruboxistaurin (LY333531) mesylate is a bisindolylmaleimide that shows a high degree of specificity within the protein kinase C (PKC) gene family for inhibiting PKC beta isoforms. bisindolylmaleimide 39-58 protein kinase C, beta Rattus norvegicus 160-168 12749991-3 2003 We found that lipopolysaccharide (LPS)-induced TNF alpha is strongly suppressed by pretreatment with specific protein kinase C (PKC) inhibitors, Go6976 and bisindolylmaleimide, suggesting that PKC alpha plays a role in the signaling cascade of TNF alpha induction. bisindolylmaleimide 156-175 tumor necrosis factor Rattus norvegicus 47-56 12733988-9 2003 PKC-induced phosphorylation of PKC-activated 17 kDa inhibitor protein of type 1 phosphatase (CPI-17) at Thr38 was abolished by bisindolylmaleimide and inhibited partly by Y27632 (28+/-3%). bisindolylmaleimide 127-146 protein phosphatase 1 regulatory inhibitor subunit 14A Homo sapiens 93-99 12720544-6 2003 Activation of S6K1/2 by PE was blocked by the broad-spectrum PKC inhibitor bisindolylmaleimide (BIM) I, whereas Go6976, a compound that only inhibits Ca(2+)-dependent PKCs, did not inhibit S6K activation. bisindolylmaleimide 75-94 ribosomal protein S6 kinase B1 Homo sapiens 14-20 12720544-6 2003 Activation of S6K1/2 by PE was blocked by the broad-spectrum PKC inhibitor bisindolylmaleimide (BIM) I, whereas Go6976, a compound that only inhibits Ca(2+)-dependent PKCs, did not inhibit S6K activation. bisindolylmaleimide 96-99 ribosomal protein S6 kinase B1 Homo sapiens 14-20 12721299-6 2003 Alboaggregin-A-dependent activation of Fyn is blocked by bisindolylmaleimide I, suggesting a role for PKC isoforms in regulating Fyn activity. bisindolylmaleimide 57-76 FYN proto-oncogene, Src family tyrosine kinase Homo sapiens 39-42 12721299-8 2003 Translocation of Fyn and PKCdelta are blocked by PP1 and bisindolylmaleimide I, showing a dependence upon Src and PKC kinase activities. bisindolylmaleimide 57-76 FYN proto-oncogene, Src family tyrosine kinase Homo sapiens 17-20 12721299-8 2003 Translocation of Fyn and PKCdelta are blocked by PP1 and bisindolylmaleimide I, showing a dependence upon Src and PKC kinase activities. bisindolylmaleimide 57-76 protein kinase C delta Homo sapiens 25-33 12721299-8 2003 Translocation of Fyn and PKCdelta are blocked by PP1 and bisindolylmaleimide I, showing a dependence upon Src and PKC kinase activities. bisindolylmaleimide 57-76 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 106-109 12721299-8 2003 Translocation of Fyn and PKCdelta are blocked by PP1 and bisindolylmaleimide I, showing a dependence upon Src and PKC kinase activities. bisindolylmaleimide 57-76 protein kinase C delta Homo sapiens 25-28 12839867-13 2003 The inhibitory effect of ET-1 was not affected by bisindolylmaleimide, SB 203580 or indomethacin, inhibitors of protein kinase C, p38-MAP kinase and cyclooxygenase, respectively, and was not associated with cAMP production. bisindolylmaleimide 50-69 endothelin 1 Mus musculus 25-29 12749991-3 2003 We found that lipopolysaccharide (LPS)-induced TNF alpha is strongly suppressed by pretreatment with specific protein kinase C (PKC) inhibitors, Go6976 and bisindolylmaleimide, suggesting that PKC alpha plays a role in the signaling cascade of TNF alpha induction. bisindolylmaleimide 156-175 protein kinase C, alpha Rattus norvegicus 128-131 12749991-3 2003 We found that lipopolysaccharide (LPS)-induced TNF alpha is strongly suppressed by pretreatment with specific protein kinase C (PKC) inhibitors, Go6976 and bisindolylmaleimide, suggesting that PKC alpha plays a role in the signaling cascade of TNF alpha induction. bisindolylmaleimide 156-175 protein kinase C, alpha Rattus norvegicus 193-202 12749991-3 2003 We found that lipopolysaccharide (LPS)-induced TNF alpha is strongly suppressed by pretreatment with specific protein kinase C (PKC) inhibitors, Go6976 and bisindolylmaleimide, suggesting that PKC alpha plays a role in the signaling cascade of TNF alpha induction. bisindolylmaleimide 156-175 tumor necrosis factor Rattus norvegicus 244-253 12646577-9 2003 Bisindolylmaleimide, an inhibitor of PKC, reduced the PGF2 alpha-induced VEGF synthesis. bisindolylmaleimide 0-19 vascular endothelial growth factor A Mus musculus 73-77 12771945-4 2003 Block of PKC activity by bisindolylmaleimide or chronic phorbol esters treatment decreased EGF-induced serine/threonine phosphorylation of E/R, while it caused a similarly sized increase of EGF-induced E/R tyrosine kinase activity and mitogenic signaling. bisindolylmaleimide 25-44 protein kinase C alpha Homo sapiens 9-12 12576304-5 2003 cPLA(2) activity was inhibited to the same extent (35 +/- 3 to 41 +/- 5%) by the m3 antagonist 4-diphenylacetoxy-N-methylpiperdine (4-DAMP), the phosphoinositide hydrolysis inhibitor U-73122, the PKC inhibitor bisindolylmaleimide, and the ERK1/2 inhibitor PD 98059. bisindolylmaleimide 210-229 phospholipase A2 group IVA Homo sapiens 0-6 12694400-2 2003 The adenosine A2A receptor-mediated facilitation was not changed by inhibitors of protein kinase A, protein kinase G or calmodulin kinase II but was prevented by inhibition of protein kinase C with chelerythrine or bisindolylmaleimide XI. bisindolylmaleimide 215-234 adenosine A2a receptor Rattus norvegicus 4-26 12626328-6 2003 Incubation (>5 h) with the PKC inhibitor bis-indolylmaleimide augmented both currents, whereas the PKC activator dioctanoyl-rac-glycerol (DiC8) prevented the augmentation of currents by quinapril. bisindolylmaleimide 44-64 protein kinase C, gamma Rattus norvegicus 30-33 12551748-4 2003 The cell death was suppressed by a protein kinase C (PKC) activator, 12,13-phorbol myristate acetate, but was enhanced by PKC specific inhibitor calphostin C or bisindolylmaleimide, not by PKC inhibitor relatively specific for PKC-alpha (safingol) or PKC-delta (rottlerin). bisindolylmaleimide 161-180 protein kinase C, alpha Rattus norvegicus 227-236 12522093-4 2003 The L-type calcium channel blocker nifedipine (10 microM), and the PKC inhibitors Go 6976 (1 microM) and bisindolylmaleimide (1 microM) also inhibited phenylephrine-induced contractions. bisindolylmaleimide 105-124 protein kinase C alpha Homo sapiens 67-70 12581868-8 2003 Chronic exposure to the protein kinase C inhibitors bisindolylmaleimide and calphostin C blocked increased production of both fibronectin and collagen XII from cells under tension. bisindolylmaleimide 52-71 fibronectin 1 Homo sapiens 126-137 12401518-2 2003 In this study, we found that in A549 and HEK293 cells non-selective PKC inhibitors Ro 31-8220 and bisindolylmaleimide VIII, and PKCbeta inhibitor LY 379196, caused Akt/PKB phosphorylation at Ser 473 and increased the upstream activator, integrin-linked kinase (ILK) activity. bisindolylmaleimide 98-117 protein kinase C beta Homo sapiens 68-71 12401518-2 2003 In this study, we found that in A549 and HEK293 cells non-selective PKC inhibitors Ro 31-8220 and bisindolylmaleimide VIII, and PKCbeta inhibitor LY 379196, caused Akt/PKB phosphorylation at Ser 473 and increased the upstream activator, integrin-linked kinase (ILK) activity. bisindolylmaleimide 98-117 cytochrome c oxidase subunit 8A Homo sapiens 118-122 12401518-2 2003 In this study, we found that in A549 and HEK293 cells non-selective PKC inhibitors Ro 31-8220 and bisindolylmaleimide VIII, and PKCbeta inhibitor LY 379196, caused Akt/PKB phosphorylation at Ser 473 and increased the upstream activator, integrin-linked kinase (ILK) activity. bisindolylmaleimide 98-117 AKT serine/threonine kinase 1 Homo sapiens 164-167 12401518-2 2003 In this study, we found that in A549 and HEK293 cells non-selective PKC inhibitors Ro 31-8220 and bisindolylmaleimide VIII, and PKCbeta inhibitor LY 379196, caused Akt/PKB phosphorylation at Ser 473 and increased the upstream activator, integrin-linked kinase (ILK) activity. bisindolylmaleimide 98-117 AKT serine/threonine kinase 1 Homo sapiens 168-171 12401518-2 2003 In this study, we found that in A549 and HEK293 cells non-selective PKC inhibitors Ro 31-8220 and bisindolylmaleimide VIII, and PKCbeta inhibitor LY 379196, caused Akt/PKB phosphorylation at Ser 473 and increased the upstream activator, integrin-linked kinase (ILK) activity. bisindolylmaleimide 98-117 integrin linked kinase Homo sapiens 237-259 12401518-2 2003 In this study, we found that in A549 and HEK293 cells non-selective PKC inhibitors Ro 31-8220 and bisindolylmaleimide VIII, and PKCbeta inhibitor LY 379196, caused Akt/PKB phosphorylation at Ser 473 and increased the upstream activator, integrin-linked kinase (ILK) activity. bisindolylmaleimide 98-117 integrin linked kinase Homo sapiens 261-264 12500029-6 2003 The authors conclude that (a) ETA receptors and protein kinase C are involved in the modulation of hypoxic pulmonary vasoconstriction; and (b) the ETA antagonist BQ-123 opposes hypoxic pulmonary vasoconstriction through KATP, KV, and BKCa channels, differing in this from the protein kinase C inhibitor bisindolylmaleimide I. bisindolylmaleimide 303-322 endothelin receptor type A Rattus norvegicus 30-33 12500029-6 2003 The authors conclude that (a) ETA receptors and protein kinase C are involved in the modulation of hypoxic pulmonary vasoconstriction; and (b) the ETA antagonist BQ-123 opposes hypoxic pulmonary vasoconstriction through KATP, KV, and BKCa channels, differing in this from the protein kinase C inhibitor bisindolylmaleimide I. bisindolylmaleimide 303-322 endothelin receptor type A Rattus norvegicus 147-150 12490592-4 2003 ATP pretreatment effects on 5-HT 1A agonist responsiveness were blocked by the protein kinase inhibitors staurosporine and bisindolylmaleimide, suggesting that the ATP-mediated temporal regulation involves activation of protein kinase C (PKC). bisindolylmaleimide 123-142 5-hydroxytryptamine receptor 1A Homo sapiens 28-35 12169276-3 2002 The PKC-specific inhibitor bisindolylmaleimide and the PKCdelta inhibitor rottlerin enhanced TNF-induced cell death. bisindolylmaleimide 27-46 protein kinase C delta Homo sapiens 4-7 12557751-9 2002 Stimulation of SMC migration by A-SAA was inhibited by both polyclonal and monoclonal antibodies to human SAA1 and also by the inhibitors of fPRL1 signaling, wortmannin, bisindolylmaleimide and pertussis toxin. bisindolylmaleimide 170-189 serum amyloid A1 cluster Homo sapiens 34-37 12417254-6 2002 Furthermore, the use of bisindolylmaleimide (BIM), a non-selective PKC inhibitor, serves to demonstrate the specificity of the PKC-dependent MARCKS-psd phosphorylation. bisindolylmaleimide 24-43 myristoylated alanine rich protein kinase C substrate Homo sapiens 141-147 12417254-6 2002 Furthermore, the use of bisindolylmaleimide (BIM), a non-selective PKC inhibitor, serves to demonstrate the specificity of the PKC-dependent MARCKS-psd phosphorylation. bisindolylmaleimide 45-48 myristoylated alanine rich protein kinase C substrate Homo sapiens 141-147 12385023-3 2002 Inhibition of PKC activation using bisindolylmaleimide (Bis), a pan-PKC inhibitor, was associated with a dose-dependent decrease of LPS-induced IL-12 production. bisindolylmaleimide 35-54 protein kinase C alpha Homo sapiens 14-17 12385023-3 2002 Inhibition of PKC activation using bisindolylmaleimide (Bis), a pan-PKC inhibitor, was associated with a dose-dependent decrease of LPS-induced IL-12 production. bisindolylmaleimide 35-54 protein kinase C alpha Homo sapiens 68-71 12385023-3 2002 Inhibition of PKC activation using bisindolylmaleimide (Bis), a pan-PKC inhibitor, was associated with a dose-dependent decrease of LPS-induced IL-12 production. bisindolylmaleimide 56-59 protein kinase C alpha Homo sapiens 14-17 12385023-3 2002 Inhibition of PKC activation using bisindolylmaleimide (Bis), a pan-PKC inhibitor, was associated with a dose-dependent decrease of LPS-induced IL-12 production. bisindolylmaleimide 56-59 protein kinase C alpha Homo sapiens 68-71 12385023-5 2002 Consistent with the diminished IL-12 synthesis, DC stimulated with LPS in presence of Bis were deficient in the induction of IFN-gamma production by allogeneic CD4+ T cells. bisindolylmaleimide 86-89 interferon gamma Homo sapiens 125-134 12231451-6 2002 The effects of phorbol esters were antagonized by the specific PKC blockers bisindolylmaleimide and calphostin C. bisindolylmaleimide 76-95 Prkca Cavia porcellus 63-66 12077118-4 2002 Protein kinase C inhibitors (bisindolylmaleimide, calphostin C) and inhibitors of mitogen-activated protein/extracellular signal regulated kinase kinase (MEK) (PD98059 and U0126) suppressed up-regulation of MUC2. bisindolylmaleimide 29-48 mucin 2, oligomeric mucus/gel-forming Homo sapiens 207-211 12205158-9 2002 Down-regulation of protein kinase C (PKC) with the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) or PKC inhibition with bisindolylmaleimide attenuated the actions of PACAP, indicating that PKC also couples PACAP to potentiation of depolarization-induced Ca(2+) transients. bisindolylmaleimide 132-151 proline rich transmembrane protein 2 Homo sapiens 112-115 12205158-9 2002 Down-regulation of protein kinase C (PKC) with the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) or PKC inhibition with bisindolylmaleimide attenuated the actions of PACAP, indicating that PKC also couples PACAP to potentiation of depolarization-induced Ca(2+) transients. bisindolylmaleimide 132-151 adenylate cyclase activating polypeptide 1 Homo sapiens 178-183 12205158-9 2002 Down-regulation of protein kinase C (PKC) with the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) or PKC inhibition with bisindolylmaleimide attenuated the actions of PACAP, indicating that PKC also couples PACAP to potentiation of depolarization-induced Ca(2+) transients. bisindolylmaleimide 132-151 proline rich transmembrane protein 2 Homo sapiens 112-115 12169276-3 2002 The PKC-specific inhibitor bisindolylmaleimide and the PKCdelta inhibitor rottlerin enhanced TNF-induced cell death. bisindolylmaleimide 27-46 tumor necrosis factor Homo sapiens 93-96 12034736-0 2002 Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. bisindolylmaleimide 0-19 cytochrome c oxidase subunit 8A Homo sapiens 20-24 12034736-0 2002 Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. bisindolylmaleimide 0-19 TNF receptor superfamily member 10b Homo sapiens 34-37 12034736-0 2002 Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. bisindolylmaleimide 0-19 mitogen-activated protein kinase kinase 4 Homo sapiens 69-73 12034736-0 2002 Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. bisindolylmaleimide 0-19 mitogen-activated protein kinase 8 Homo sapiens 74-77 12034736-0 2002 Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. bisindolylmaleimide 0-19 mitogen-activated protein kinase 14 Homo sapiens 78-81 12034736-1 2002 Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism. bisindolylmaleimide 0-19 cytochrome c oxidase subunit 8A Homo sapiens 20-24 12034736-1 2002 Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism. bisindolylmaleimide 0-19 cytochrome c oxidase subunit 8A Homo sapiens 30-34 12110518-6 2002 Proton extrusion capacity of ATP1AL1-transfected cells is drastically reduced after phorbol 12-myristate 13-acetate incubation and can be prevented with the PKC blocker bisindolylmaleimide. bisindolylmaleimide 169-188 ATPase H+/K+ transporting non-gastric alpha2 subunit Homo sapiens 29-36 12110518-6 2002 Proton extrusion capacity of ATP1AL1-transfected cells is drastically reduced after phorbol 12-myristate 13-acetate incubation and can be prevented with the PKC blocker bisindolylmaleimide. bisindolylmaleimide 169-188 proline rich transmembrane protein 2 Homo sapiens 157-160 12163389-4 2002 We found that the emergence of resistance to Apo2L/TRAIL, after prolonged incubation with this cytokine, was associated with increased levels of FLICE inhibitory protein (FLIP), and was overcome by cycloheximide and bisindolylmaleimide, that specifically down-regulated FLIP expression, as well as by transfection of a FLIP anti-sense oligonucleotide. bisindolylmaleimide 216-235 TNF superfamily member 10 Homo sapiens 45-50 12163389-4 2002 We found that the emergence of resistance to Apo2L/TRAIL, after prolonged incubation with this cytokine, was associated with increased levels of FLICE inhibitory protein (FLIP), and was overcome by cycloheximide and bisindolylmaleimide, that specifically down-regulated FLIP expression, as well as by transfection of a FLIP anti-sense oligonucleotide. bisindolylmaleimide 216-235 TNF superfamily member 10 Homo sapiens 51-56 12021392-6 2002 The protein kinase C (PKC) inhibitor bisindolylmaleimide (1 microM) completely blocked PMA/FP-induced TNFalpha secretion in U937 cells and attenuated apoptosis. bisindolylmaleimide 37-56 tumor necrosis factor Homo sapiens 102-110 12023032-2 2002 Here, we report that the bisindolylmaleimide derivative Ro 31-6045, previously reported to be inactive as a kinase inhibitor, inhibited S6K activity in vivo with an IC50=8 microM. bisindolylmaleimide 25-44 ribosomal protein S6 kinase B1 Homo sapiens 136-139 11943676-5 2002 Diacylglycerol (DAG)-dependent protein kinase C (PKC) isoenzymes, involved in the DA-mediated activation of ERK proteins as pretreatment with either bisindolylmaleimide or Ro-31-8220, prevented the phosphorylation of Elk-1, and quinpirole, a D(2)R activator, stimulates the translocation of PKCepsilon. bisindolylmaleimide 149-168 protein kinase C epsilon Homo sapiens 49-52 11943676-5 2002 Diacylglycerol (DAG)-dependent protein kinase C (PKC) isoenzymes, involved in the DA-mediated activation of ERK proteins as pretreatment with either bisindolylmaleimide or Ro-31-8220, prevented the phosphorylation of Elk-1, and quinpirole, a D(2)R activator, stimulates the translocation of PKCepsilon. bisindolylmaleimide 149-168 mitogen-activated protein kinase 1 Homo sapiens 108-111 11943676-5 2002 Diacylglycerol (DAG)-dependent protein kinase C (PKC) isoenzymes, involved in the DA-mediated activation of ERK proteins as pretreatment with either bisindolylmaleimide or Ro-31-8220, prevented the phosphorylation of Elk-1, and quinpirole, a D(2)R activator, stimulates the translocation of PKCepsilon. bisindolylmaleimide 149-168 ETS transcription factor ELK1 Homo sapiens 217-222 11943676-5 2002 Diacylglycerol (DAG)-dependent protein kinase C (PKC) isoenzymes, involved in the DA-mediated activation of ERK proteins as pretreatment with either bisindolylmaleimide or Ro-31-8220, prevented the phosphorylation of Elk-1, and quinpirole, a D(2)R activator, stimulates the translocation of PKCepsilon. bisindolylmaleimide 149-168 protein kinase C epsilon Homo sapiens 291-301 11950946-5 2002 Down-regulation of diacylglycerol-sensitive types of protein kinase C (PKC) by pretreatment with phorbol 12-myristate 13-acetate or inhibition with bisindolylmaleimide prevented the DA-mediated increase in Na,K-ATPase activity and exocytosis of Na,K-pumps to the BLM. bisindolylmaleimide 148-167 protein kinase C alpha Homo sapiens 71-74 11877293-5 2002 Higher levels of expression for various apoptosis inhibitors, including FLICE-inhibitory protein (FLIP), and lower procaspase-8 levels were present in TRAIL-resistant cells and sensitivity was restored by the protein synthesis inhibitor cycloheximide (CHX) and the protein kinase C (PKC) inhibitor bisindolylmaleimide (BIM), which both lowered FLIP and cellular inhibitor of apoptosis protein-2 (cIAP-2) protein levels. bisindolylmaleimide 298-317 TNF superfamily member 10 Homo sapiens 151-156 11877293-5 2002 Higher levels of expression for various apoptosis inhibitors, including FLICE-inhibitory protein (FLIP), and lower procaspase-8 levels were present in TRAIL-resistant cells and sensitivity was restored by the protein synthesis inhibitor cycloheximide (CHX) and the protein kinase C (PKC) inhibitor bisindolylmaleimide (BIM), which both lowered FLIP and cellular inhibitor of apoptosis protein-2 (cIAP-2) protein levels. bisindolylmaleimide 319-322 TNF superfamily member 10 Homo sapiens 151-156 11873046-12 2002 Inhibition of PKC with bisindolylmaleimide (broad range inhibitor) or Go 6976 (inhibitor of Ca2+-dependent PKC isoforms) abolished propofol-induced inhibition of isoproterenol-stimulated increases in [Ca2+]i, shortening, and cAMP production. bisindolylmaleimide 23-42 protein kinase C, alpha Rattus norvegicus 14-17 11861786-4 2002 This effect was significantly reduced by the PKC-specific inhibitor bisindolylmaleimide (GF109203X), by down-regulation of PKC with 12-O-tetradecanoyl-phorbol 13-acetate, by a pseudosubstrate to PKCalpha, and by selective down-regulation of PKCalpha by prior lead exposure. bisindolylmaleimide 68-87 protein kinase C alpha Homo sapiens 45-48 11861786-4 2002 This effect was significantly reduced by the PKC-specific inhibitor bisindolylmaleimide (GF109203X), by down-regulation of PKC with 12-O-tetradecanoyl-phorbol 13-acetate, by a pseudosubstrate to PKCalpha, and by selective down-regulation of PKCalpha by prior lead exposure. bisindolylmaleimide 68-87 protein kinase C alpha Homo sapiens 123-126 11861786-4 2002 This effect was significantly reduced by the PKC-specific inhibitor bisindolylmaleimide (GF109203X), by down-regulation of PKC with 12-O-tetradecanoyl-phorbol 13-acetate, by a pseudosubstrate to PKCalpha, and by selective down-regulation of PKCalpha by prior lead exposure. bisindolylmaleimide 68-87 protein kinase C alpha Homo sapiens 195-203 11861786-4 2002 This effect was significantly reduced by the PKC-specific inhibitor bisindolylmaleimide (GF109203X), by down-regulation of PKC with 12-O-tetradecanoyl-phorbol 13-acetate, by a pseudosubstrate to PKCalpha, and by selective down-regulation of PKCalpha by prior lead exposure. bisindolylmaleimide 68-87 protein kinase C alpha Homo sapiens 241-249 11911960-11 2002 332 (1996) 142) was inhibited with bisindolylmaleimide treatment, suggesting that PKCalpha may be involved in the 1,25-(OH)2D3-mediated regulation of osteocalcin gene expression. bisindolylmaleimide 35-54 protein kinase C, alpha Rattus norvegicus 82-90 11911960-11 2002 332 (1996) 142) was inhibited with bisindolylmaleimide treatment, suggesting that PKCalpha may be involved in the 1,25-(OH)2D3-mediated regulation of osteocalcin gene expression. bisindolylmaleimide 35-54 bone gamma-carboxyglutamate protein Rattus norvegicus 150-161 12088101-6 2002 We noted that PMA greatly stimulated MUC1 synthesis and its shedding to culture medium and that this effect was abolished by protein kinase C specific inhibitor--bisindolylmaleimide. bisindolylmaleimide 162-181 mucin 1, cell surface associated Homo sapiens 37-41 11841576-4 2002 The C8-ceramide-induced BDNF release was significantly suppressed by protein kinase C (PKC) inhibitor, bisindolylmaleimide, which targets PKC isoforms, alpha, beta, gamma, delta and epsilon. bisindolylmaleimide 103-122 brain derived neurotrophic factor Homo sapiens 24-28 11841576-4 2002 The C8-ceramide-induced BDNF release was significantly suppressed by protein kinase C (PKC) inhibitor, bisindolylmaleimide, which targets PKC isoforms, alpha, beta, gamma, delta and epsilon. bisindolylmaleimide 103-122 protein kinase C alpha Homo sapiens 87-90 11841576-4 2002 The C8-ceramide-induced BDNF release was significantly suppressed by protein kinase C (PKC) inhibitor, bisindolylmaleimide, which targets PKC isoforms, alpha, beta, gamma, delta and epsilon. bisindolylmaleimide 103-122 protein kinase C alpha Homo sapiens 138-189 11781100-4 2002 Furthermore, PKC phosphorylation of SHP2 was completely blocked by the PKC inhibitor bisindolylmaleimide and was not detectable when SHP2 was co-overexpressed with kinase negative mutants of PKC beta 1 and -beta 2. bisindolylmaleimide 85-104 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 36-40 11684691-6 2002 Using the protein kinase A inhibitor H-89, the protein kinase C inhibitor bisindolylmaleimide, and the mitogen-activated protein kinase kinase inhibitor PD98059, we found that the melatonin-mediated cyclical regulation of GnRH mRNA expression may involve the protein kinase C and the extracellular signal-regulated kinase 1 and 2 pathways, but not the protein kinase A pathway. bisindolylmaleimide 74-93 gonadotropin releasing hormone 1 Mus musculus 222-226 11772805-7 2002 The protein kinase C inhibitor bisindolylmaleimide I (bisindolylmaleimide) enhanced the SP-induced Cl(-) currents. bisindolylmaleimide 31-50 tachykinin precursor 1 S homeolog Xenopus laevis 88-90 11701232-3 2001 Inhibition of protein kinase C (PKC) activity using bisindolylmaleimide or calphostin C abolished the increased PPARalpha expression by the peroxisome proliferators whereas the expression of the ACOX gene remained unaffected. bisindolylmaleimide 52-71 peroxisome proliferator activated receptor alpha Rattus norvegicus 112-121 11731549-9 2001 We have also investigated the contribution of various second-messenger pathways in these actions of NGF by treating the cells with blockers of MAP kinase (PD98059), protein kinase A (PKA; PKAI14-22, H89), and PKC (Bisindolylmaleimide I). bisindolylmaleimide 214-233 nerve growth factor Homo sapiens 100-103 11602671-8 2001 Agonist-induced desensitization of the 5-HT2A, but not the 5-HT2C, receptor system was reduced by the PKC inhibitors staurosporine and bisindolylmaleimide, and by down-regulation of PKC. bisindolylmaleimide 135-154 5-hydroxytryptamine receptor 2A Homo sapiens 39-45 11524420-6 2001 PDD (100 nm, phorbol ester activator of protein kinase C (PKC)) simulates and bisindolylmaleimide (50 nm, PKC inhibitor) weakens phenylephrine modulation of Ito but not IK1. bisindolylmaleimide 78-97 proline rich transmembrane protein 2 Homo sapiens 106-109 11594774-3 2001 The protein kinase C (PKC) inhibitor bisindolylmaleimide abolished PDGF but not IGF-I or insulin-induced ERK activation. bisindolylmaleimide 37-56 proline rich transmembrane protein 2 Homo sapiens 4-20 11594774-3 2001 The protein kinase C (PKC) inhibitor bisindolylmaleimide abolished PDGF but not IGF-I or insulin-induced ERK activation. bisindolylmaleimide 37-56 proline rich transmembrane protein 2 Homo sapiens 22-25 11557588-6 2001 The structurally unrelated protein kinase C inhibitors bisindolylmaleimide, Ro-31-8220, and Go-6976 all blocked fMLP/B-induced EPO release but not LTC(4) secretion. bisindolylmaleimide 55-74 formyl peptide receptor 1 Homo sapiens 112-116 11557588-6 2001 The structurally unrelated protein kinase C inhibitors bisindolylmaleimide, Ro-31-8220, and Go-6976 all blocked fMLP/B-induced EPO release but not LTC(4) secretion. bisindolylmaleimide 55-74 eosinophil peroxidase Homo sapiens 127-130 11478501-4 2001 The transepithelial permeability increase was prevented by coincubation with the protein kinase C (PKC) inhibitor bisindolylmaleimide. bisindolylmaleimide 114-133 protein kinase C alpha Homo sapiens 99-102 11602666-6 2001 In addition, pretreatment with bisindolylmaleimide, a specific PKC inhibitor, partially reversed the suppression of PMA on rat oatp1-, and almost completely reversed the suppression of PMA on rat oatp2-mediated uptake. bisindolylmaleimide 31-50 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 127-132 11602666-6 2001 In addition, pretreatment with bisindolylmaleimide, a specific PKC inhibitor, partially reversed the suppression of PMA on rat oatp1-, and almost completely reversed the suppression of PMA on rat oatp2-mediated uptake. bisindolylmaleimide 31-50 solute carrier organic anion transporter family, member 1a4 Rattus norvegicus 196-201 11549345-5 2001 The possible role of alphaB crystallin in the protection afforded by ischemic preconditioning is supported by the signal transduction data; which showed preconditioning-induced alphaB crystallin phosphorylation can be blocked by tyrosine kinase inhibition (using genistein) and by p38 MAP kinase or PKC inhibition (using SB203580 or bisindolylmaleimide, respectively). bisindolylmaleimide 333-352 crystallin, alpha B Rattus norvegicus 21-38 11549345-5 2001 The possible role of alphaB crystallin in the protection afforded by ischemic preconditioning is supported by the signal transduction data; which showed preconditioning-induced alphaB crystallin phosphorylation can be blocked by tyrosine kinase inhibition (using genistein) and by p38 MAP kinase or PKC inhibition (using SB203580 or bisindolylmaleimide, respectively). bisindolylmaleimide 333-352 crystallin, alpha B Rattus norvegicus 177-194 11494368-6 2001 Pre-treatment of microglia with a PKC inhibitor, bisindolylmaleimide, suppressed LPS-stimulated BDNF secretion as well as the constitutive one. bisindolylmaleimide 49-68 protein kinase C, alpha Rattus norvegicus 34-37 11494368-6 2001 Pre-treatment of microglia with a PKC inhibitor, bisindolylmaleimide, suppressed LPS-stimulated BDNF secretion as well as the constitutive one. bisindolylmaleimide 49-68 brain-derived neurotrophic factor Rattus norvegicus 96-100 11313339-3 2001 We demonstrate that in human choriocarcinoma BeWo cells, the PKC activator 12-O-tetradecanoyl phorbol 13-acetate and PKC inhibitor bisindolylmaleimide reciprocally down- and up-regulate, respectively, TEF-mediated GGAATG core enhancer activity. bisindolylmaleimide 131-150 TEF transcription factor, PAR bZIP family member Homo sapiens 201-204 11334846-9 2001 The selective inhibitor of protein kinase C, bisindolylmaleimide (5x10(-6) M) attenuated the response to sarafotoxin 6c (10(-7) M) by 78% and that to endothelin-1 (10(-7) M), elicited in the presence of A192621 (10(-10) M), by 52%. bisindolylmaleimide 45-64 endothelin 1 Rattus norvegicus 150-162 11383922-3 2001 The effects of the sterol on the Ca2+ entry pathway were abolished by the PKC inhibitors bisindolylmaleimide and calphostin. bisindolylmaleimide 89-108 protein kinase C alpha Gallus gallus 74-77 11299321-4 2001 Pretreatment of cells with the PKC inhibitor bisindolylmaleimide blocked the decrease in 5-HT(2A) receptor mRNA levels, and attenuated the down-regulation of 5-HT(2A) receptor binding sites induced by treatment with 5-HT. bisindolylmaleimide 45-64 protein kinase C alpha Homo sapiens 31-34 11299321-4 2001 Pretreatment of cells with the PKC inhibitor bisindolylmaleimide blocked the decrease in 5-HT(2A) receptor mRNA levels, and attenuated the down-regulation of 5-HT(2A) receptor binding sites induced by treatment with 5-HT. bisindolylmaleimide 45-64 5-hydroxytryptamine receptor 2A Homo sapiens 89-106 11299321-4 2001 Pretreatment of cells with the PKC inhibitor bisindolylmaleimide blocked the decrease in 5-HT(2A) receptor mRNA levels, and attenuated the down-regulation of 5-HT(2A) receptor binding sites induced by treatment with 5-HT. bisindolylmaleimide 45-64 5-hydroxytryptamine receptor 2A Homo sapiens 158-175 11282458-3 2001 In islets treated with bisindolylmaleimide (BIM), a PKC inhibitor, PMA significantly reduced the glucose-induced insulin secretion. bisindolylmaleimide 23-42 protein kinase C, gamma Rattus norvegicus 52-55 11282458-3 2001 In islets treated with bisindolylmaleimide (BIM), a PKC inhibitor, PMA significantly reduced the glucose-induced insulin secretion. bisindolylmaleimide 44-47 protein kinase C, gamma Rattus norvegicus 52-55 11241551-12 2001 Whereas the PKC inhibitor bisindolylmaleimide prevented phorbol ester-induced apoptosis in LNCaP cells, it did not affect ceramide-induced cell death. bisindolylmaleimide 26-45 proline rich transmembrane protein 2 Homo sapiens 12-15 11162606-2 2001 Bisindolylmaleimide (BIM), an inhibitor of PKC, either alone (MCF-7 and BT-20) or in combination with cycloheximide enhanced sensitivity of these cells to TNF. bisindolylmaleimide 0-19 protein kinase C delta Homo sapiens 43-46 11162606-2 2001 Bisindolylmaleimide (BIM), an inhibitor of PKC, either alone (MCF-7 and BT-20) or in combination with cycloheximide enhanced sensitivity of these cells to TNF. bisindolylmaleimide 0-19 tumor necrosis factor Homo sapiens 155-158 11162606-2 2001 Bisindolylmaleimide (BIM), an inhibitor of PKC, either alone (MCF-7 and BT-20) or in combination with cycloheximide enhanced sensitivity of these cells to TNF. bisindolylmaleimide 21-24 protein kinase C delta Homo sapiens 43-46 11162606-2 2001 Bisindolylmaleimide (BIM), an inhibitor of PKC, either alone (MCF-7 and BT-20) or in combination with cycloheximide enhanced sensitivity of these cells to TNF. bisindolylmaleimide 21-24 tumor necrosis factor Homo sapiens 155-158 11162606-4 2001 MCF-7, BT-20 and MDA-MB-231 cells that were most responsive to BIM-mediated sensitization to TNF contained relatively high level of PKC epsilon and proteolytic cleavage of PKC epsilon correlated with TNF-induced cell death. bisindolylmaleimide 63-66 tumor necrosis factor Homo sapiens 93-96 11162606-4 2001 MCF-7, BT-20 and MDA-MB-231 cells that were most responsive to BIM-mediated sensitization to TNF contained relatively high level of PKC epsilon and proteolytic cleavage of PKC epsilon correlated with TNF-induced cell death. bisindolylmaleimide 63-66 protein kinase C epsilon Homo sapiens 132-143 11162606-4 2001 MCF-7, BT-20 and MDA-MB-231 cells that were most responsive to BIM-mediated sensitization to TNF contained relatively high level of PKC epsilon and proteolytic cleavage of PKC epsilon correlated with TNF-induced cell death. bisindolylmaleimide 63-66 protein kinase C epsilon Homo sapiens 172-183 11162606-4 2001 MCF-7, BT-20 and MDA-MB-231 cells that were most responsive to BIM-mediated sensitization to TNF contained relatively high level of PKC epsilon and proteolytic cleavage of PKC epsilon correlated with TNF-induced cell death. bisindolylmaleimide 63-66 tumor necrosis factor Homo sapiens 200-203 11162606-5 2001 BIM did not inhibit NF-kappa B activation by TNF but caused activation of caspases and enhanced cleavage of PKC delta and -epsilon. bisindolylmaleimide 0-3 protein kinase C delta Homo sapiens 108-130 11120810-4 2000 Extracellular signal-regulated kinase (ERK) activation in CTL stimulated with soluble cross-linked anti-CD3 is completely inhibited by the PKC inhibitor bisindolylmaleimide (BIM). bisindolylmaleimide 153-172 mitogen-activated protein kinase 1 Homo sapiens 0-37 11112424-6 2000 The activation of these caspases was potentiated by the PKC inhibitor bisindolylmaleimide (BIM) which downregulates PKC eta and sensitizes cells to TNF. bisindolylmaleimide 70-89 caspase 8 Homo sapiens 24-32 11112424-6 2000 The activation of these caspases was potentiated by the PKC inhibitor bisindolylmaleimide (BIM) which downregulates PKC eta and sensitizes cells to TNF. bisindolylmaleimide 70-89 tumor necrosis factor Homo sapiens 148-151 11112424-6 2000 The activation of these caspases was potentiated by the PKC inhibitor bisindolylmaleimide (BIM) which downregulates PKC eta and sensitizes cells to TNF. bisindolylmaleimide 91-94 caspase 8 Homo sapiens 24-32 11112424-6 2000 The activation of these caspases was potentiated by the PKC inhibitor bisindolylmaleimide (BIM) which downregulates PKC eta and sensitizes cells to TNF. bisindolylmaleimide 91-94 tumor necrosis factor Homo sapiens 148-151 11090109-15 2000 These responses were prevented by inhibition of protein kinase C (PKC) with bis-indolyl-maleimide. bisindolylmaleimide 76-97 proline rich transmembrane protein 2 Homo sapiens 48-64 11090109-15 2000 These responses were prevented by inhibition of protein kinase C (PKC) with bis-indolyl-maleimide. bisindolylmaleimide 76-97 proline rich transmembrane protein 2 Homo sapiens 66-69 11120810-4 2000 Extracellular signal-regulated kinase (ERK) activation in CTL stimulated with soluble cross-linked anti-CD3 is completely inhibited by the PKC inhibitor bisindolylmaleimide (BIM). bisindolylmaleimide 153-172 mitogen-activated protein kinase 1 Homo sapiens 39-42 11120810-4 2000 Extracellular signal-regulated kinase (ERK) activation in CTL stimulated with soluble cross-linked anti-CD3 is completely inhibited by the PKC inhibitor bisindolylmaleimide (BIM). bisindolylmaleimide 174-177 mitogen-activated protein kinase 1 Homo sapiens 0-37 11120810-4 2000 Extracellular signal-regulated kinase (ERK) activation in CTL stimulated with soluble cross-linked anti-CD3 is completely inhibited by the PKC inhibitor bisindolylmaleimide (BIM). bisindolylmaleimide 174-177 mitogen-activated protein kinase 1 Homo sapiens 39-42 11120810-9 2000 These results indicate that the late phase of MAPK activation in CTL clones in response to immobilized anti-CD3 stimulation requires PKC while the early phase requires a DAG-dependent, BIM-resistant component. bisindolylmaleimide 185-188 mitogen-activated protein kinase 1 Homo sapiens 46-50 11102964-6 2000 A pharmacological study using a specific PKC activator, phorbol-12-myristate-13-acetate, and a protein kinase C (PKC) inhibitor, bisindolylmaleimide, showed that PKC activation is required in order to release uPA from ceramide-stimulated microglia as well as from nonstimulated microglia. bisindolylmaleimide 129-148 protein kinase C delta Homo sapiens 113-116 11042115-6 2000 The PKC-specific inhibitors bisindolylmaleimide and Go 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLC gamma and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent manner. bisindolylmaleimide 28-47 protein kinase C alpha Homo sapiens 4-7 11042115-6 2000 The PKC-specific inhibitors bisindolylmaleimide and Go 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLC gamma and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent manner. bisindolylmaleimide 28-47 insulin Homo sapiens 68-75 11042115-6 2000 The PKC-specific inhibitors bisindolylmaleimide and Go 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLC gamma and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent manner. bisindolylmaleimide 28-47 phospholipase D2 Homo sapiens 84-88 11042115-6 2000 The PKC-specific inhibitors bisindolylmaleimide and Go 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLC gamma and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent manner. bisindolylmaleimide 28-47 insulin receptor Homo sapiens 135-151 11042115-6 2000 The PKC-specific inhibitors bisindolylmaleimide and Go 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLC gamma and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent manner. bisindolylmaleimide 28-47 phospholipase D2 Homo sapiens 167-171 11042115-6 2000 The PKC-specific inhibitors bisindolylmaleimide and Go 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLC gamma and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent manner. bisindolylmaleimide 28-47 phospholipase D1 Homo sapiens 198-202 11042115-6 2000 The PKC-specific inhibitors bisindolylmaleimide and Go 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLC gamma and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent manner. bisindolylmaleimide 28-47 phospholipase D2 Homo sapiens 167-171 11042115-6 2000 The PKC-specific inhibitors bisindolylmaleimide and Go 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLC gamma and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent manner. bisindolylmaleimide 28-47 protein kinase C alpha Homo sapiens 240-243 11058554-12 2000 Moreover, bisindolylmaleimide (100 nM), a protein kinase C (PKC) inhibitor decreased significantly by 28.7% the TNFalpha effect on LDH(A4) activity but had no effect on the stimulating action of sphingosine, suggesting that if PKC is involved in TNFalpha action, the sphingosine effect on LDH(A4) is unrelated to the PKC activity or inhibition. bisindolylmaleimide 10-29 tumor necrosis factor Homo sapiens 112-120 11058554-12 2000 Moreover, bisindolylmaleimide (100 nM), a protein kinase C (PKC) inhibitor decreased significantly by 28.7% the TNFalpha effect on LDH(A4) activity but had no effect on the stimulating action of sphingosine, suggesting that if PKC is involved in TNFalpha action, the sphingosine effect on LDH(A4) is unrelated to the PKC activity or inhibition. bisindolylmaleimide 10-29 tumor necrosis factor Homo sapiens 246-254 11102964-6 2000 A pharmacological study using a specific PKC activator, phorbol-12-myristate-13-acetate, and a protein kinase C (PKC) inhibitor, bisindolylmaleimide, showed that PKC activation is required in order to release uPA from ceramide-stimulated microglia as well as from nonstimulated microglia. bisindolylmaleimide 129-148 protein kinase C delta Homo sapiens 113-116 11102964-6 2000 A pharmacological study using a specific PKC activator, phorbol-12-myristate-13-acetate, and a protein kinase C (PKC) inhibitor, bisindolylmaleimide, showed that PKC activation is required in order to release uPA from ceramide-stimulated microglia as well as from nonstimulated microglia. bisindolylmaleimide 129-148 plasminogen activator, urokinase Homo sapiens 209-212 10997919-6 2000 Unlike many effects of HG, augmentation of ERK activity by HG was not dependent on protein kinase C (PKC) as indicated by downregulation of PKC with 24-h phorbol ester or inhibition with bisindolylmaleimide IV. bisindolylmaleimide 187-206 mitogen-activated protein kinase 1 Homo sapiens 43-46 11003572-3 2000 Phosphorylation of Galpha(i-1) and Galpha(i-2) and blockade of cyclase inhibition were reversed by calphostin C and bisindolylmaleimide, and additively by selective inhibitors of PKCalpha and PKCepsilon. bisindolylmaleimide 116-135 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 19-29 11003572-3 2000 Phosphorylation of Galpha(i-1) and Galpha(i-2) and blockade of cyclase inhibition were reversed by calphostin C and bisindolylmaleimide, and additively by selective inhibitors of PKCalpha and PKCepsilon. bisindolylmaleimide 116-135 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 35-45 10893407-4 2000 This effect of thrombin was significantly reduced by protein kinase C inhibitors, such as Go6976, bisindolylmaleimide, and Ro31-8220. bisindolylmaleimide 98-117 coagulation factor II Rattus norvegicus 15-23 10986013-8 2000 Preincubation of the granulocytes with the protein kinase C inhibitor bisindolylmaleimide reduced the DCF fluorescence stimulated with TMCH, fMLP, and PMA by 82, 56, and 90%, respectively. bisindolylmaleimide 70-89 formyl peptide receptor 1 Homo sapiens 141-145 10960082-7 2000 In that case the expression of the protein remained high at least up to 12 h. Treatment of cells with protein kinase C inhibitors (H-7, bisindolylmaleimide and calphostin C) inhibited IL-1beta stimulation of PGE(2). bisindolylmaleimide 136-155 interleukin 1 beta Mus musculus 184-192 10960082-13 2000 ERK1/2 activation by IL-1beta was sensitive to inhibition by the PKC inhibitor bisindolylmaleimide suggesting that ERK phosphorylation is a downstream signal of PKC activation. bisindolylmaleimide 79-98 mitogen-activated protein kinase 3 Mus musculus 0-6 10960082-13 2000 ERK1/2 activation by IL-1beta was sensitive to inhibition by the PKC inhibitor bisindolylmaleimide suggesting that ERK phosphorylation is a downstream signal of PKC activation. bisindolylmaleimide 79-98 interleukin 1 beta Mus musculus 21-29 10960082-13 2000 ERK1/2 activation by IL-1beta was sensitive to inhibition by the PKC inhibitor bisindolylmaleimide suggesting that ERK phosphorylation is a downstream signal of PKC activation. bisindolylmaleimide 79-98 mitogen-activated protein kinase 1 Mus musculus 0-3 10969040-5 2000 The administration of high concentrations of D-glucose induced a dose-dependent increase in the Pa value, which was prevented by blockage of PKC with its selective inhibitors bisindolylmaleimide and Goe 6976. bisindolylmaleimide 175-194 proline rich transmembrane protein 2 Homo sapiens 141-144 11281731-4 2000 IGF1-induced activation of p44/p42 MAP kinase was blocked by preincubation with the PKC inhibitors, bisindolylmaleimide and Go6976, as well as the tyrosine kinase inhibitor, genistein. bisindolylmaleimide 100-119 insulin-like growth factor 1 Rattus norvegicus 0-4 11281731-4 2000 IGF1-induced activation of p44/p42 MAP kinase was blocked by preincubation with the PKC inhibitors, bisindolylmaleimide and Go6976, as well as the tyrosine kinase inhibitor, genistein. bisindolylmaleimide 100-119 mitogen activated protein kinase 3 Rattus norvegicus 27-30 10919265-12 2000 In the present study, we observed that bisindolylmaleimide (BIM), a nonspecific PKCs inhibitor partially prevented the NPY-induced CRF release. bisindolylmaleimide 39-58 neuropeptide Y Homo sapiens 119-122 10919265-12 2000 In the present study, we observed that bisindolylmaleimide (BIM), a nonspecific PKCs inhibitor partially prevented the NPY-induced CRF release. bisindolylmaleimide 60-63 neuropeptide Y Homo sapiens 119-122 10947162-9 2000 Inhibition of protein kinase C with H7 or bisindolylmaleimide prevented TNF secretion and ERK 1/2 activation by LPSa. bisindolylmaleimide 42-61 tumor necrosis factor Mus musculus 72-75 10947162-9 2000 Inhibition of protein kinase C with H7 or bisindolylmaleimide prevented TNF secretion and ERK 1/2 activation by LPSa. bisindolylmaleimide 42-61 mitogen-activated protein kinase 3 Mus musculus 90-97 10806212-9 2000 The cell proliferation induced by PMA in both the U-251 MG and U-1242-PKC-eta cells was blocked by the PKC inhibitor bisindolylmaleimide (0.5 micrometer) and the MEK inhibitor, PD 98059 (50 micrometer). bisindolylmaleimide 117-136 protein kinase C delta Homo sapiens 70-73 10806212-9 2000 The cell proliferation induced by PMA in both the U-251 MG and U-1242-PKC-eta cells was blocked by the PKC inhibitor bisindolylmaleimide (0.5 micrometer) and the MEK inhibitor, PD 98059 (50 micrometer). bisindolylmaleimide 117-136 protein kinase C delta Homo sapiens 103-106 10899038-8 2000 Responses were blocked by the PKC antagonists chelerythrine chloride, bisindolylmaleimide, and Go-6976. bisindolylmaleimide 70-89 protein kinase C alpha Homo sapiens 30-33 10861044-5 2000 Interestingly, the protein kinase C inhibitor, bisindolylmaleimide (compound 3), totally blocked thapsigargin-induced degranulation in both SHIP+/+ and SHIP-/- BMMCs. bisindolylmaleimide 47-66 inositol polyphosphate-5-phosphatase D Mus musculus 140-144 10861044-5 2000 Interestingly, the protein kinase C inhibitor, bisindolylmaleimide (compound 3), totally blocked thapsigargin-induced degranulation in both SHIP+/+ and SHIP-/- BMMCs. bisindolylmaleimide 47-66 inositol polyphosphate-5-phosphatase D Mus musculus 152-156 10828032-0 2000 Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide. bisindolylmaleimide 117-136 CASP8 and FADD like apoptosis regulator Homo sapiens 14-20 10828032-4 2000 We also demonstrated that bisindolylmaleimide down-regulates c-FLIP(L) expression in DC and, in parallel, allows CD95-mediated apoptosis in these cells. bisindolylmaleimide 26-45 CASP8 and FADD like apoptosis regulator Homo sapiens 61-67 10828032-4 2000 We also demonstrated that bisindolylmaleimide down-regulates c-FLIP(L) expression in DC and, in parallel, allows CD95-mediated apoptosis in these cells. bisindolylmaleimide 26-45 Fas cell surface death receptor Homo sapiens 113-117 10828032-6 2000 We conclude that DC resist CD95- mediated apoptosis in association with c-FLIP(L) expression and that the immunosuppressive potential of bisindolylmaleimide previously observed at the T-cell level also involves facilitation of CD95-mediated DC apoptosis. bisindolylmaleimide 137-156 Fas cell surface death receptor Homo sapiens 227-231 10749673-6 2000 Activation of MAPK in response to bradykinin was insensitive towards AG 1478, a specific inhibitor of EGFR tyrosine kinase, but was blocked by wortmannin or bisindolylmaleimide, inhibitors of phosphatidylinositol 3-kinase (PI3-K) and protein kinase C (PKC) respectively. bisindolylmaleimide 157-176 kininogen 1 Homo sapiens 34-44 10773038-0 2000 Direct block by bisindolylmaleimide of rat Kv1.5 expressed in Chinese hamster ovary cells. bisindolylmaleimide 16-35 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 43-48 10773038-1 2000 The interaction of bisindolylmaleimide (BIM), widely used as a specific protein kinase C (PKC) inhibitor, with rat brain Kv1.5 (rKv1.5) channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. bisindolylmaleimide 19-38 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 121-126 10773038-1 2000 The interaction of bisindolylmaleimide (BIM), widely used as a specific protein kinase C (PKC) inhibitor, with rat brain Kv1.5 (rKv1.5) channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. bisindolylmaleimide 19-38 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 128-134 10773038-1 2000 The interaction of bisindolylmaleimide (BIM), widely used as a specific protein kinase C (PKC) inhibitor, with rat brain Kv1.5 (rKv1.5) channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. bisindolylmaleimide 40-43 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 121-126 10773038-1 2000 The interaction of bisindolylmaleimide (BIM), widely used as a specific protein kinase C (PKC) inhibitor, with rat brain Kv1.5 (rKv1.5) channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. bisindolylmaleimide 40-43 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 128-134 10749673-6 2000 Activation of MAPK in response to bradykinin was insensitive towards AG 1478, a specific inhibitor of EGFR tyrosine kinase, but was blocked by wortmannin or bisindolylmaleimide, inhibitors of phosphatidylinositol 3-kinase (PI3-K) and protein kinase C (PKC) respectively. bisindolylmaleimide 157-176 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 192-221 10660461-6 2000 The selective PKC inhibitor bisindolylmaleimide reduced phosphorylation of MARCKS-PSD in a concentration-dependent manner, with greater than 95% inhibition at 1.0 microM. bisindolylmaleimide 28-47 protein kinase C, gamma Rattus norvegicus 14-17 10660461-6 2000 The selective PKC inhibitor bisindolylmaleimide reduced phosphorylation of MARCKS-PSD in a concentration-dependent manner, with greater than 95% inhibition at 1.0 microM. bisindolylmaleimide 28-47 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 75-81 10629034-5 2000 Indeed, the PKC activator phorbol 12-myristate 13-acetate induced Rap1 activation, whereas the PKC-inhibitor bisindolylmaleimide inhibited the second, but not the first, phase of Rap1 activation. bisindolylmaleimide 109-128 RAP1A, member of RAS oncogene family Homo sapiens 179-183 10662890-6 2000 Treatment of cells with GDPS, an inhibitor of G proteins, or bisindolylmaleimide (BIM), a selective protein kinase C (PKC) inhibitor, prevented the NA inhibition of the currents. bisindolylmaleimide 61-80 Prkca Cavia porcellus 100-116 10662890-6 2000 Treatment of cells with GDPS, an inhibitor of G proteins, or bisindolylmaleimide (BIM), a selective protein kinase C (PKC) inhibitor, prevented the NA inhibition of the currents. bisindolylmaleimide 61-80 Prkca Cavia porcellus 118-121 10662890-6 2000 Treatment of cells with GDPS, an inhibitor of G proteins, or bisindolylmaleimide (BIM), a selective protein kinase C (PKC) inhibitor, prevented the NA inhibition of the currents. bisindolylmaleimide 82-85 Prkca Cavia porcellus 100-116 10662890-6 2000 Treatment of cells with GDPS, an inhibitor of G proteins, or bisindolylmaleimide (BIM), a selective protein kinase C (PKC) inhibitor, prevented the NA inhibition of the currents. bisindolylmaleimide 82-85 Prkca Cavia porcellus 118-121 10601257-9 1999 alpha-Actinin resolved by two-dimensional gel electrophoresis of activated platelet lysates was recognized by the antibodies to phosphotyrosine, whereas pretreatment of the platelets with bisindolylmaleimide, a protein kinase C inhibitor that prevents tyrosine phosphorylation of pp105, inhibited the reactivity of the antibodies to phosphotyrosine with alpha-actinin. bisindolylmaleimide 188-207 actinin alpha 1 Homo sapiens 0-13 10674991-2 2000 Recently, bisindolylmaleimide has been shown to be an effective treatment of experimental autoimmune encephalomyelitis, presumably due to enhancement of CD95-mediated T cell apoptosis. bisindolylmaleimide 10-29 Fas cell surface death receptor Homo sapiens 153-157 10601257-9 1999 alpha-Actinin resolved by two-dimensional gel electrophoresis of activated platelet lysates was recognized by the antibodies to phosphotyrosine, whereas pretreatment of the platelets with bisindolylmaleimide, a protein kinase C inhibitor that prevents tyrosine phosphorylation of pp105, inhibited the reactivity of the antibodies to phosphotyrosine with alpha-actinin. bisindolylmaleimide 188-207 actinin alpha 1 Homo sapiens 354-367 10619578-7 1999 Genistein and bisindolylmaleimide significantly inhibited the fMLP-induced ROS in all groups. bisindolylmaleimide 14-33 formyl peptide receptor 1 Homo sapiens 62-66 10585882-4 1999 The pretreatment of HL-60 cells with staurosporine, chelerythrine chloride and bisindolylmaleimide abolished the activity of sphingomyelinase in response to 1,25(OH)(2)D(3) and IFN-gamma. bisindolylmaleimide 79-98 interferon gamma Homo sapiens 177-186 10564161-6 1999 HA blocked the VEGF-induced rapid and prolonged (10 min-45 h) increases in the phosphotyrosine (PY) contents of VEGF receptor 2, phospholipase C-gamma1, paxillin, and beta-catenin as well as approximately 140- and 128- to 117-kDa proteins, whereas BIM inhibited only the tyrosine phosphorylation of beta-catenin. bisindolylmaleimide 248-251 vascular endothelial growth factor A Bos taurus 15-19 10529207-1 1999 To study the activation process of protein kinase C (PKCalpha), we used a fluorescent probe, FIM-1, a bis-indolylmaleimide derivative, which binds to the ATP-binding site on the catalytic domain [Chen, C. S., and Poenie, M. (1993) J. Biol. bisindolylmaleimide 102-122 protein kinase C alpha Homo sapiens 53-61 10529207-1 1999 To study the activation process of protein kinase C (PKCalpha), we used a fluorescent probe, FIM-1, a bis-indolylmaleimide derivative, which binds to the ATP-binding site on the catalytic domain [Chen, C. S., and Poenie, M. (1993) J. Biol. bisindolylmaleimide 102-122 FIM1 Homo sapiens 93-98 10491655-8 1999 Finally, the partial inhibitory effect of a protein kinase C (PKC) inhibitor, bisindolylmaleimide, on EGF-stimulated LDH A mRNA supports a partial involvement of PKC in the action of the growth factor. bisindolylmaleimide 78-97 epidermal growth factor Homo sapiens 102-105 10491655-8 1999 Finally, the partial inhibitory effect of a protein kinase C (PKC) inhibitor, bisindolylmaleimide, on EGF-stimulated LDH A mRNA supports a partial involvement of PKC in the action of the growth factor. bisindolylmaleimide 78-97 lactate dehydrogenase A Homo sapiens 117-122 10438717-4 1999 IL-8 mRNA expression is blocked by the protein kinase C inhibitor bisindolylmaleimide or protein tyrosine kinase inhibitors, genestein and geldanamycin, establishing the involvement of the protein kinase C and protein tyrosine kinase pathways in the activation process. bisindolylmaleimide 66-85 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 10484394-10 1999 The inhibitory effect of bisindolylmaleimide suggests that protein kinase C activity is also required for caerulein-induced NF-kappaB/Rel activation. bisindolylmaleimide 25-44 nuclear factor kappa B subunit 1 Homo sapiens 124-133 10625951-7 1999 Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity. bisindolylmaleimide 140-159 protein kinase C alpha Homo sapiens 46-49 10625951-7 1999 Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity. bisindolylmaleimide 140-159 protein kinase C alpha Homo sapiens 163-166 10625951-7 1999 Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity. bisindolylmaleimide 140-159 protein kinase C epsilon Homo sapiens 245-256 10625951-7 1999 Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity. bisindolylmaleimide 140-159 protein kinase C alpha Homo sapiens 284-293 10395936-4 1999 On the contrary, bisindolylmaleimide Ro 32-0432 (which inhibits PKC at its ATP binding site) abolished entirely PDBu-stimulated PLC activity. bisindolylmaleimide 17-36 proline rich transmembrane protein 2 Homo sapiens 64-67 10431833-2 1999 To better understand early events implicated in this process, we have used bisindolylmaleimide (GF109203X), an inhibitor with a high selectivity for protein kinase C (PKC). bisindolylmaleimide 75-94 proline rich transmembrane protein 2 Homo sapiens 149-165 10431833-2 1999 To better understand early events implicated in this process, we have used bisindolylmaleimide (GF109203X), an inhibitor with a high selectivity for protein kinase C (PKC). bisindolylmaleimide 75-94 proline rich transmembrane protein 2 Homo sapiens 167-170 10353884-7 1999 This effect was bisindolylmaleimide-reversible, suggesting involvement of PKC. bisindolylmaleimide 16-35 proline rich transmembrane protein 2 Homo sapiens 74-77 10353884-9 1999 In a cell-free assay, inhibition of PKC activation by bisindolylmaleimide could be reversed by thalidomide, indicating direct interactions of thalidomide with PKC. bisindolylmaleimide 54-73 proline rich transmembrane protein 2 Homo sapiens 36-39 10353884-9 1999 In a cell-free assay, inhibition of PKC activation by bisindolylmaleimide could be reversed by thalidomide, indicating direct interactions of thalidomide with PKC. bisindolylmaleimide 54-73 proline rich transmembrane protein 2 Homo sapiens 159-162 10408834-8 1999 On the contrary, an inhibitor of protein kinase C (bis-indolyl-maleimide, BIM) was effective only in the FMLP/Lym-1 cytolytic system. bisindolylmaleimide 51-72 formyl peptide receptor 1 Homo sapiens 105-109 10362694-5 1999 Stimulation of PKC-zeta was prevented by the generic PKC inhibitor GF109203x (bisindolylmaleimide, 10 microM). bisindolylmaleimide 78-97 protein kinase C zeta Homo sapiens 15-23 10362694-5 1999 Stimulation of PKC-zeta was prevented by the generic PKC inhibitor GF109203x (bisindolylmaleimide, 10 microM). bisindolylmaleimide 78-97 proline rich transmembrane protein 2 Homo sapiens 15-18 10331492-5 1999 The specific PKC inhibitor bisindolylmaleimide (GF 109203x) did not affect the insulin-stimulated chemokinesis at 5 mM glucose but restored the chemokinetic effect of insulin at 15 mM glucose. bisindolylmaleimide 27-46 insulin Homo sapiens 167-174 9990296-4 1999 MARCKS phosphorylation was inhibited by staurosporine, bis-indolylmaleimide (a PKC-specific inhibitor), Go6983 (inhibits all isoforms except PKC mu), and a peptide from the calmodulin-binding domain of MARCKS, but was unaffected by EGTA or Go6976 (inhibits cPKCs and PKC mu). bisindolylmaleimide 55-75 myristoylated alanine rich protein kinase C substrate Homo sapiens 0-6 10066763-5 1999 The PKC-mediated activation of Pit-2 was blocked by pretreating cells with the pan-PKC inhibitor bisindolylmaleimide but not with the conventional PKC isotype inhibitor Go 6976, suggesting that a novel PKC isotype is required to regulate Pit-2. bisindolylmaleimide 97-116 solute carrier family 20, member 2 Mus musculus 31-36 10067856-8 1999 Similarly, activation of PK-C, by treatment with phorbol 12-myristate 13-acetate, elicited only a minimal increase in constitutive receptor endocytosis; and blockade of the PK-C pathway, by treatment with a bisindolylmaleimide, failed to inhibit agonist-induced receptor endocytosis. bisindolylmaleimide 207-226 proline rich transmembrane protein 2 Homo sapiens 25-29 10072259-7 1999 Preincubation of HUVECs with the PKC inhibitors bis-indolylmaleimide (BIN) or calphostin C or the TK inhibitors genistein or herbimycin A (HMA) blocked the TNF-alpha-induced increase in H82 cell attachment. bisindolylmaleimide 48-68 tumor necrosis factor Homo sapiens 156-165 9920881-5 1999 We have purified Fos kinase by affinity chromatography using the Sepharose-linked protein kinase inhibitor, bisindolylmaleimide (BIM). bisindolylmaleimide 108-127 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 17-20 9920881-5 1999 We have purified Fos kinase by affinity chromatography using the Sepharose-linked protein kinase inhibitor, bisindolylmaleimide (BIM). bisindolylmaleimide 129-132 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 17-20 9950855-4 1999 VEGF (10(-10) M) induced a two- to threefold increase in Pa, which was blocked by a monoclonal antibody directed against the VEGF receptor Flk-1/KDR, the phospholipase C (PLC) antagonist U-73122, or the protein kinase C (PKC) antagonist bisindolylmaleimide (BIM). bisindolylmaleimide 237-256 vascular endothelial growth factor A Homo sapiens 0-4 9950855-4 1999 VEGF (10(-10) M) induced a two- to threefold increase in Pa, which was blocked by a monoclonal antibody directed against the VEGF receptor Flk-1/KDR, the phospholipase C (PLC) antagonist U-73122, or the protein kinase C (PKC) antagonist bisindolylmaleimide (BIM). bisindolylmaleimide 237-256 vascular endothelial growth factor A Homo sapiens 125-129 9950855-4 1999 VEGF (10(-10) M) induced a two- to threefold increase in Pa, which was blocked by a monoclonal antibody directed against the VEGF receptor Flk-1/KDR, the phospholipase C (PLC) antagonist U-73122, or the protein kinase C (PKC) antagonist bisindolylmaleimide (BIM). bisindolylmaleimide 237-256 kinase insert domain receptor Homo sapiens 139-144 9950855-4 1999 VEGF (10(-10) M) induced a two- to threefold increase in Pa, which was blocked by a monoclonal antibody directed against the VEGF receptor Flk-1/KDR, the phospholipase C (PLC) antagonist U-73122, or the protein kinase C (PKC) antagonist bisindolylmaleimide (BIM). bisindolylmaleimide 258-261 vascular endothelial growth factor A Homo sapiens 0-4 9950855-4 1999 VEGF (10(-10) M) induced a two- to threefold increase in Pa, which was blocked by a monoclonal antibody directed against the VEGF receptor Flk-1/KDR, the phospholipase C (PLC) antagonist U-73122, or the protein kinase C (PKC) antagonist bisindolylmaleimide (BIM). bisindolylmaleimide 258-261 vascular endothelial growth factor A Homo sapiens 125-129 9950855-4 1999 VEGF (10(-10) M) induced a two- to threefold increase in Pa, which was blocked by a monoclonal antibody directed against the VEGF receptor Flk-1/KDR, the phospholipase C (PLC) antagonist U-73122, or the protein kinase C (PKC) antagonist bisindolylmaleimide (BIM). bisindolylmaleimide 258-261 kinase insert domain receptor Homo sapiens 139-144 9950855-8 1999 In contrast, U-73122 and BIM were able to inhibit VEGF-elicited serine phosphorylation of ecNOS. bisindolylmaleimide 25-28 vascular endothelial growth factor A Homo sapiens 50-54 9950855-8 1999 In contrast, U-73122 and BIM were able to inhibit VEGF-elicited serine phosphorylation of ecNOS. bisindolylmaleimide 25-28 nitric oxide synthase 3 Homo sapiens 90-95 9974403-9 1999 Inhibition of protein kinase C (bisindolylmaleimide) diminished fibrinogen binding and sensitization by LDL; inhibition of tyrosine kinases (herbimycin A) left fibrinogen binding unchanged but diminished sensitization by LDL. bisindolylmaleimide 32-51 fibrinogen beta chain Homo sapiens 64-74 9885289-7 1999 These effects were blocked by concentrations of bis-indolylmaleimide that selectively inhibit protein kinase C. Finally, ablation of SSeCKS expression using retroviral anti-sense vectors induced (1) an elongated, fibroblastic cell morphology, (2) production of thick, longitudinal stress fibers and (3) repositioning of vinculin-associated focal complexes away from the cell edges. bisindolylmaleimide 48-68 A-kinase anchoring protein 12 Homo sapiens 133-139 9885289-7 1999 These effects were blocked by concentrations of bis-indolylmaleimide that selectively inhibit protein kinase C. Finally, ablation of SSeCKS expression using retroviral anti-sense vectors induced (1) an elongated, fibroblastic cell morphology, (2) production of thick, longitudinal stress fibers and (3) repositioning of vinculin-associated focal complexes away from the cell edges. bisindolylmaleimide 48-68 vinculin Homo sapiens 320-328 10470381-1 1999 The macrocyclic bisindolylmaleimide, LY333531, selectively inhibits protein kinase C beta 1 and beta 2 isoforms with an approximate IC50 of 5 nanomolar. bisindolylmaleimide 16-35 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 96-102 9870951-6 1999 PACAP caused G-protein- and phospholipase C-mediated calcium release from inositol-trisphosphate-sensitive stores and subsequent protein kinase C-mediated calcium influx, demonstrated by treatment with GDP-beta-S, neomycin, U-73122, calcium-free saline, thapsigargin, bisindolylmaleimide, and chelerythrine. bisindolylmaleimide 268-287 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 9883838-0 1999 Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. bisindolylmaleimide 0-19 cytochrome c oxidase subunit 8A Homo sapiens 20-24 9883838-2 1999 Bisindolylmaleimide VIII potentiated Fas-mediated apoptosis in human astrocytoma 1321N1 cells and in Molt-4T cells, both of which were devoid of apoptosis induced by anti-Fas antibody in the absence of bisindolylmaleimide VIII, and in Jurkat and CEM-6 T cells, which showed slight and moderate apoptotic responses, respectively, to low levels of Fas stimulation. bisindolylmaleimide 0-19 cytochrome c oxidase subunit 8A Homo sapiens 20-24 9883838-2 1999 Bisindolylmaleimide VIII potentiated Fas-mediated apoptosis in human astrocytoma 1321N1 cells and in Molt-4T cells, both of which were devoid of apoptosis induced by anti-Fas antibody in the absence of bisindolylmaleimide VIII, and in Jurkat and CEM-6 T cells, which showed slight and moderate apoptotic responses, respectively, to low levels of Fas stimulation. bisindolylmaleimide 0-19 cytochrome c oxidase subunit 8A Homo sapiens 222-226 9883838-2 1999 Bisindolylmaleimide VIII potentiated Fas-mediated apoptosis in human astrocytoma 1321N1 cells and in Molt-4T cells, both of which were devoid of apoptosis induced by anti-Fas antibody in the absence of bisindolylmaleimide VIII, and in Jurkat and CEM-6 T cells, which showed slight and moderate apoptotic responses, respectively, to low levels of Fas stimulation. bisindolylmaleimide 202-221 cytochrome c oxidase subunit 8A Homo sapiens 20-24 9883838-4 1999 Administration of bisindolylmaleimide VIII to rats during autoantigen stimulation prevented the development of symptoms of T cell-mediated autoimmune diseases in two models, the Lewis rat model of experimental allergic encephalitis and the Lewis adjuvant arthritis model. bisindolylmaleimide 18-37 cytochrome c oxidase subunit 8A Homo sapiens 38-42 9883838-5 1999 Thus, the use of agents such as bisindolylmaleimide VIII may be therapeutically useful for supporting more effective elimination of detrimental cells through enhancement of Fas-dependent apoptosis signaling. bisindolylmaleimide 32-51 cytochrome c oxidase subunit 8A Homo sapiens 52-56 9822674-3 1998 Both BK-induced stimulation of DNA synthesis and activation of MAPK in response to BK were abolished by two different inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY 294002, as well as by two different inhibitors of protein kinase C (PKC), bisindolylmaleimide and Ro 31-8220. bisindolylmaleimide 262-281 kininogen 1 Homo sapiens 5-7 9822674-3 1998 Both BK-induced stimulation of DNA synthesis and activation of MAPK in response to BK were abolished by two different inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY 294002, as well as by two different inhibitors of protein kinase C (PKC), bisindolylmaleimide and Ro 31-8220. bisindolylmaleimide 262-281 kininogen 1 Homo sapiens 83-85 9794108-8 1998 A 10 mumol/l concentration of the protein kinase C (PKC) inhibitor bisindolylmaleimide attenuated insulin action but at 1 mumol/l it was ineffective, suggesting involvement of the atypical PKC-zeta isoform. bisindolylmaleimide 67-86 protein kinase C zeta Homo sapiens 52-55 9794108-8 1998 A 10 mumol/l concentration of the protein kinase C (PKC) inhibitor bisindolylmaleimide attenuated insulin action but at 1 mumol/l it was ineffective, suggesting involvement of the atypical PKC-zeta isoform. bisindolylmaleimide 67-86 insulin Homo sapiens 98-105 9658185-3 1998 This effect was not observed with phorbol esters that do not activate PKC and was blocked by bisindolylmaleimide, a specific PKC inhibitor. bisindolylmaleimide 93-112 protein kinase C, gamma Rattus norvegicus 70-73 9658185-3 1998 This effect was not observed with phorbol esters that do not activate PKC and was blocked by bisindolylmaleimide, a specific PKC inhibitor. bisindolylmaleimide 93-112 protein kinase C, gamma Rattus norvegicus 125-128 9601059-5 1998 PMA-stimulated PLD activity was blocked by the PKC inhibitor bisindolylmaleimide. bisindolylmaleimide 61-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-18 9601059-5 1998 PMA-stimulated PLD activity was blocked by the PKC inhibitor bisindolylmaleimide. bisindolylmaleimide 61-80 protein kinase C alpha Homo sapiens 47-50 9604867-11 1998 The PKC inhibitors staurosporine, bisindolylmaleimide, and AMG-C16 blocked the stimulated translocation of PKC-alpha and -beta, but not that of PKC-zeta. bisindolylmaleimide 34-53 protein kinase C, alpha Rattus norvegicus 4-7 9604867-11 1998 The PKC inhibitors staurosporine, bisindolylmaleimide, and AMG-C16 blocked the stimulated translocation of PKC-alpha and -beta, but not that of PKC-zeta. bisindolylmaleimide 34-53 protein kinase C, alpha Rattus norvegicus 107-116 9665588-0 1998 Bisindolylmaleimide prevents cerebellar granule cells apoptosis: a possible role for PKC. bisindolylmaleimide 0-19 proline rich transmembrane protein 2 Homo sapiens 85-88 9665588-4 1998 Bisindolylmaleimide, a specific protein kinase C (PKC) inhibitor, blocks cell death and apoptosis with an optimal concentration of 10 microM. bisindolylmaleimide 0-19 proline rich transmembrane protein 2 Homo sapiens 32-48 9665588-4 1998 Bisindolylmaleimide, a specific protein kinase C (PKC) inhibitor, blocks cell death and apoptosis with an optimal concentration of 10 microM. bisindolylmaleimide 0-19 proline rich transmembrane protein 2 Homo sapiens 50-53 9578554-7 1998 The stimulation mediated by GalR1 was inhibited by expression of the C-terminus of beta-adrenergic receptor kinase (beta ARKct), which specifically inhibits G beta gamma signaling, but was not affected by the protein kinase C (PKC) inhibitor, bis[indolylmaleimide], or cellular depletion of PKC. bisindolylmaleimide 243-263 Galanin receptor type 1 Cricetulus griseus 28-33 9561801-4 1998 The implication of protein kinase C (PKC) in this effect seems clear since bisindolylmaleimide (BIS), a specific PKC inhibitor, completely blocks the PDB effect on AFP expression. bisindolylmaleimide 75-94 PDB1 Homo sapiens 150-153 9561801-4 1998 The implication of protein kinase C (PKC) in this effect seems clear since bisindolylmaleimide (BIS), a specific PKC inhibitor, completely blocks the PDB effect on AFP expression. bisindolylmaleimide 75-94 alpha fetoprotein Homo sapiens 164-167 9561801-4 1998 The implication of protein kinase C (PKC) in this effect seems clear since bisindolylmaleimide (BIS), a specific PKC inhibitor, completely blocks the PDB effect on AFP expression. bisindolylmaleimide 96-99 PDB1 Homo sapiens 150-153 9561801-4 1998 The implication of protein kinase C (PKC) in this effect seems clear since bisindolylmaleimide (BIS), a specific PKC inhibitor, completely blocks the PDB effect on AFP expression. bisindolylmaleimide 96-99 alpha fetoprotein Homo sapiens 164-167 9685216-5 1998 PKC activation was inhibited by the specific PKC inhibitor bisindolylmaleimide (GF109203X). bisindolylmaleimide 59-78 proline rich transmembrane protein 2 Homo sapiens 0-3 9685216-5 1998 PKC activation was inhibited by the specific PKC inhibitor bisindolylmaleimide (GF109203X). bisindolylmaleimide 59-78 proline rich transmembrane protein 2 Homo sapiens 45-48 9607141-3 1998 Bisindolylmaleimide inhibits TPA- and TPA+ insulin-induced PI-3 kinase activity. bisindolylmaleimide 0-19 insulin Homo sapiens 43-50 9469459-6 1998 Although previously shown to inhibit IL-4 secretion, the phorbol ester PMA was a potent stimulus for IL-13 generation from basophils, and this secretion was sensitive to the protein kinase C inhibitor, bisindolylmaleimide. bisindolylmaleimide 202-221 interleukin 4 Homo sapiens 37-41 9469459-6 1998 Although previously shown to inhibit IL-4 secretion, the phorbol ester PMA was a potent stimulus for IL-13 generation from basophils, and this secretion was sensitive to the protein kinase C inhibitor, bisindolylmaleimide. bisindolylmaleimide 202-221 interleukin 13 Homo sapiens 101-106 9487139-3 1998 Phosphorylation of rabbit OSBP stably overexpressed in CHO-K1 cells was altered by staurosporine and okadaic acid, while other protein kinase activators and inhibitors such as TPA, sphingosine and bis-indolylmaleimide were without affect. bisindolylmaleimide 197-217 oxysterol-binding protein 1 Oryctolagus cuniculus 26-30 9490073-13 1998 Also, treatment with the PKC-specific inhibitor bisindolylmaleimide suppressed the antigen-induced MpII PTP activity enhancement. bisindolylmaleimide 48-67 protein kinase C, gamma Rattus norvegicus 25-28 9490073-13 1998 Also, treatment with the PKC-specific inhibitor bisindolylmaleimide suppressed the antigen-induced MpII PTP activity enhancement. bisindolylmaleimide 48-67 protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus 104-107 9463471-4 1998 Unlike staurosporine, the selective PKC inhibitors, chelerythrine and bisindolylmaleimide, augmented the initial EPSP increase. bisindolylmaleimide 70-89 proline rich transmembrane protein 2 Homo sapiens 36-39 9605511-10 1998 The co-localization of PACAP and cAMP responsiveness as well as the results of studies involving specific inhibitors of protein kinase A (H-89) or protein kinase C (PKC) (bisindolylmaleimide) suggests that the action of PACAP on alpha-subunit transcription is mediated primarily by the protein kinase A (PKA) pathway. bisindolylmaleimide 171-190 adenylate cyclase activating polypeptide 1 Mus musculus 220-225 9447865-9 1998 In the presence of the protein kinase C (PKC) inhibitor bisindolylmaleimide (BIS), the effect of halothane was unchanged. bisindolylmaleimide 56-75 Prkca Cavia porcellus 23-39 9447865-9 1998 In the presence of the protein kinase C (PKC) inhibitor bisindolylmaleimide (BIS), the effect of halothane was unchanged. bisindolylmaleimide 56-75 Prkca Cavia porcellus 41-44 9447865-9 1998 In the presence of the protein kinase C (PKC) inhibitor bisindolylmaleimide (BIS), the effect of halothane was unchanged. bisindolylmaleimide 77-80 Prkca Cavia porcellus 23-39 9447865-9 1998 In the presence of the protein kinase C (PKC) inhibitor bisindolylmaleimide (BIS), the effect of halothane was unchanged. bisindolylmaleimide 77-80 Prkca Cavia porcellus 41-44 9458327-3 1998 CB elevation induced by LPS alone or LPS followed by IFN- was blocked by protein kinase C (PKC) inhibitors staurosporine, H-7, phloretin and bisindolylmaleimide, and by cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89 and cAMP-dependent protein kinase (PKA) inhibitor. bisindolylmaleimide 141-160 cathepsin B Homo sapiens 0-2 9458327-3 1998 CB elevation induced by LPS alone or LPS followed by IFN- was blocked by protein kinase C (PKC) inhibitors staurosporine, H-7, phloretin and bisindolylmaleimide, and by cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89 and cAMP-dependent protein kinase (PKA) inhibitor. bisindolylmaleimide 141-160 interferon alpha 1 Homo sapiens 53-57 9769475-3 1998 Treatment of cells with PKC inhibitors (staurosporine, bisindolylmaleimide, or G?6976) resulted in morphological alterations and reorganization of actin filaments similar to retinoic-acid-treated cells. bisindolylmaleimide 55-74 protein kinase C alpha Homo sapiens 24-27 9389491-4 1997 Insulin-stimulated phosphorylation of the alpha-subunit of FTase in 3T3-L1 fibroblasts and adipocytes was blocked by the mitogen-activated protein/extracellular-signal regulated kinase-kinase inhibitor, PD98059, but not by wortmannin or bisindolylmaleimide. bisindolylmaleimide 237-256 insulin Homo sapiens 0-7 9287347-6 1997 In cells expressing a point-mutated FGFR-1, Y766F, unable to mediate PKC activation, p70(s6k) was still activated, in a bisindolylmaleimide- and phorbol ester-resistant manner. bisindolylmaleimide 120-139 Fibroblast growth factor receptor 1 Rattus norvegicus 36-42 9400820-5 1997 CD14-dependent phagocytosis was inhibited by a phosphatidylinositol (PI) 3-kinase inhibitor (wortmannin) and a protein tyrosine kinase inhibitor (tyrphostin 23) but not a protein kinase C inhibitor (bisindolyl-maleimide) or a divalent cation chelator (ethylenediaminetetraacetate). bisindolylmaleimide 199-219 CD14 molecule Homo sapiens 0-4 9417875-9 1997 In contrast, both calphostin C and bisindolylmaleimide, specific inhibitors of protein kinase C, consistently increased by 30-50% the ratio of nuclear-bound/total amount of the cyclin protein. bisindolylmaleimide 35-54 proliferating cell nuclear antigen Homo sapiens 177-183 9374783-10 1997 The selective PKC inhibitor bisindolylmaleimide abolished the effect of PMA but did not alter the effect of histamines on Pa. bisindolylmaleimide 28-47 proline rich transmembrane protein 2 Homo sapiens 14-17 9366465-10 1997 The actions of TPA were blocked by pretreatment with the selective PKC inhibitor bisindolylmaleimide, but not by inhibition of protein synthesis with cycloheximide or anisomycin. bisindolylmaleimide 81-100 proline rich transmembrane protein 2 Homo sapiens 67-70 9322938-7 1997 This effect was prevented by the PKC inhibitor bisindolylmaleimide (GF-109203). bisindolylmaleimide 47-66 proline rich transmembrane protein 2 Homo sapiens 33-36 9336344-6 1997 BIM at 3 microM totally abrogated Erk2 phosphorylation. bisindolylmaleimide 0-3 mitogen-activated protein kinase 1 Mus musculus 34-38 9287347-6 1997 In cells expressing a point-mutated FGFR-1, Y766F, unable to mediate PKC activation, p70(s6k) was still activated, in a bisindolylmaleimide- and phorbol ester-resistant manner. bisindolylmaleimide 120-139 ribosomal protein S6 kinase B1 Rattus norvegicus 89-92 9346296-9 1997 PLD stimulation by PMA in HEK cell membranes required MgATP and was largely prevented by the selective PKC inhibitors Goe 6976 and bisindolylmaleimide I. Immunoblot analysis demonstrated that both conventional PKC (alpha, beta, gamma) and atypical PKC isozymes (zeta, tau) were present in HEK cell membranes. bisindolylmaleimide 131-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 9346296-9 1997 PLD stimulation by PMA in HEK cell membranes required MgATP and was largely prevented by the selective PKC inhibitors Goe 6976 and bisindolylmaleimide I. Immunoblot analysis demonstrated that both conventional PKC (alpha, beta, gamma) and atypical PKC isozymes (zeta, tau) were present in HEK cell membranes. bisindolylmaleimide 131-150 protein kinase C alpha Homo sapiens 103-106 9346296-9 1997 PLD stimulation by PMA in HEK cell membranes required MgATP and was largely prevented by the selective PKC inhibitors Goe 6976 and bisindolylmaleimide I. Immunoblot analysis demonstrated that both conventional PKC (alpha, beta, gamma) and atypical PKC isozymes (zeta, tau) were present in HEK cell membranes. bisindolylmaleimide 131-150 protein kinase C alpha Homo sapiens 210-251 9288674-12 1997 Although ET-1 has been shown to activate specific protein kinase C (PKC) isoforms, a significant inhibitory effect of ET-1 was maintained in the presence of the PKC inhibitor bisindolylmaleimide (20 nM). bisindolylmaleimide 175-194 Prkca Cavia porcellus 50-66 9288674-12 1997 Although ET-1 has been shown to activate specific protein kinase C (PKC) isoforms, a significant inhibitory effect of ET-1 was maintained in the presence of the PKC inhibitor bisindolylmaleimide (20 nM). bisindolylmaleimide 175-194 Prkca Cavia porcellus 68-71 9288674-12 1997 Although ET-1 has been shown to activate specific protein kinase C (PKC) isoforms, a significant inhibitory effect of ET-1 was maintained in the presence of the PKC inhibitor bisindolylmaleimide (20 nM). bisindolylmaleimide 175-194 endothelin-1 Cavia porcellus 118-122 9288674-12 1997 Although ET-1 has been shown to activate specific protein kinase C (PKC) isoforms, a significant inhibitory effect of ET-1 was maintained in the presence of the PKC inhibitor bisindolylmaleimide (20 nM). bisindolylmaleimide 175-194 Prkca Cavia porcellus 161-164 9225067-13 1997 To test this hypothesis directly, we incubated the cells with two bisindolylmaleimide PKC inhibitors during the addition of 1,25-dihydroxyvitamin D3 and TGF beta 1. bisindolylmaleimide 66-85 protein kinase C alpha Homo sapiens 86-89 9169462-12 1997 Specific protein kinase C inhibitors (bisindolylmaleimide (GF109203X) and calphostin C) blocked the activation of NF-kappaB by each compound. bisindolylmaleimide 38-57 nuclear factor kappa B subunit 1 Homo sapiens 114-123 9227606-7 1997 However, pHi acidification stimulated protein kinase C (PKC) activity and inhibition of PKC by PKC inhibitors (bisindolylmaleimide, calphostin C, or staurosporine) or prolonged exposure to phorbol ester abrogated the inhibitory effect of pHi acidification on cell Pi uptake. bisindolylmaleimide 111-130 glucose-6-phosphate isomerase Homo sapiens 9-12 9151737-8 1997 In the presence of the protein kinase C inhibitor bisindolylmaleimide, BDNF-induced survival promotion is reduced partially, whereas NGF-induced death is unmasked. bisindolylmaleimide 50-69 brain derived neurotrophic factor Homo sapiens 71-75 9139671-4 1997 Treatment of cells with selective protein kinase inhibitors revealed that Nef phosphorylation was markedly reduced by bisindolylmaleimide, an inhibitor of protein kinase C, but was unaffected by inhibitors of mitogen-activated protein kinase kinase or cAMP-dependent kinase. bisindolylmaleimide 118-137 S100 calcium binding protein B Homo sapiens 74-77 9139741-12 1997 The selective PKC enzyme inhibitor, bisindolylmaleimide, reduced PDB-stimulated AP-1 activity, but enhanced RA-induced AP-1 activity. bisindolylmaleimide 36-55 protein kinase C, alpha Mus musculus 14-17 9176149-5 1997 In CCL39 fibroblasts, rSEV increased total phosphoinositol (PI) formation (6- to 10-fold at 10 nM), which was inhibited 49% by PTX; it was also partially inhibited by the tyrosine kinase inhibitor genistein (33%) but was not affected by the protein kinase C inhibitor bisindolylmaleimide. bisindolylmaleimide 268-287 kallikrein 1-related peptidase C9 Rattus norvegicus 22-26 9225067-13 1997 To test this hypothesis directly, we incubated the cells with two bisindolylmaleimide PKC inhibitors during the addition of 1,25-dihydroxyvitamin D3 and TGF beta 1. bisindolylmaleimide 66-85 transforming growth factor beta 1 Homo sapiens 153-163 9099748-9 1997 Furthermore, following down-regulation, the effect of vasopressin was still blocked by the PKC inhibitors, Ro-31-8220 and bisindolylmaleimide. bisindolylmaleimide 122-141 arginine vasopressin Homo sapiens 54-65 9142932-8 1997 Treatment with bisindolylmaleimide, a specific protein kinase C (PKC) inhibitor, and heparin attenuated polycation-mediated PLD activation. bisindolylmaleimide 15-34 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 124-127 9101406-9 1997 The inhibition of GIRK activity by mGluR1a was suppressed by a broad-specificity protein kinase inhibitor, staurosporine, and by a specific protein kinase C (PKC) inhibitor, bis-indolylmaleimide, but not by PTX, Ca(2-)chelation, or calphostin C. bisindolylmaleimide 174-194 potassium inwardly rectifying channel subfamily J member 3 L homeolog Xenopus laevis 18-22 9042336-9 1997 PAF-stimulated [3H]thymidine uptake was also prevented by PKC down regulation after long term exposure to PMA and PKC inhibition with the two inhibitors sangivamycin and bis-indolylmaleimide. bisindolylmaleimide 170-190 PCNA clamp associated factor Homo sapiens 0-3 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. bisindolylmaleimide 267-286 interleukin 1 alpha Homo sapiens 0-4 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. bisindolylmaleimide 267-286 interleukin 6 Homo sapiens 68-72 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. bisindolylmaleimide 267-286 interleukin 6 Homo sapiens 143-147 9125673-6 1997 The selective inhibitor of protein kinase C (PKC), bisindolylmaleimide (BIM) (5 microM), reduced markedly the incorporation of 2-[(14)C]uridine into cellular RNA and, to a lesser degree, the incorporation of L-U-[(14)C]phenylalanine into cellular protein in response to ET-1 (100 pM to 10 nM). bisindolylmaleimide 51-70 endothelin-1 Oryctolagus cuniculus 270-274 9125673-6 1997 The selective inhibitor of protein kinase C (PKC), bisindolylmaleimide (BIM) (5 microM), reduced markedly the incorporation of 2-[(14)C]uridine into cellular RNA and, to a lesser degree, the incorporation of L-U-[(14)C]phenylalanine into cellular protein in response to ET-1 (100 pM to 10 nM). bisindolylmaleimide 72-75 endothelin-1 Oryctolagus cuniculus 270-274 9124457-7 1997 Addition of propranolol or specific PKC inhibitors (chelerythrine or bisindolylmaleimide) during Iso infusion completely abolished the beneficial effects of Iso. bisindolylmaleimide 69-88 protein kinase C, gamma Rattus norvegicus 36-39 9071993-6 1997 Furthermore, the presence of a protein kinase C inhibitor, bisindolylmaleimide (GF 109203X), blocked hCSF-GM-mediated induction of focal adhesion kinase, implicating an important role for protein kinase C in the induction of pp125FAK. bisindolylmaleimide 59-78 protein tyrosine kinase 2 Homo sapiens 225-233 9070288-4 1997 Furthermore, CYP17 degradation by cytosolic protease(s) is 2.5-fold accelerated by ATP; this action is completely reversed by the protein kinase inhibitors bisindolylmaleimide (half-maximal protective concentration 2.04 microM) and KT5720 (99 nM). bisindolylmaleimide 156-175 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 13-18 9015316-14 1997 Increased levels of alpha2 and MMP-1 mRNA in collagen gel-stimulated fibroblasts were abrogated by bisindolylmaleimide GF 109203X and calphostin C, chemical inhibitors for PKC, but retained when cells were depleted of 12-myristate 13-acetate (PMA)-inducible PKC isoforms by 24 h of pretreatment with phorbol PMA. bisindolylmaleimide 99-118 matrix metallopeptidase 1 Homo sapiens 31-36 9015316-14 1997 Increased levels of alpha2 and MMP-1 mRNA in collagen gel-stimulated fibroblasts were abrogated by bisindolylmaleimide GF 109203X and calphostin C, chemical inhibitors for PKC, but retained when cells were depleted of 12-myristate 13-acetate (PMA)-inducible PKC isoforms by 24 h of pretreatment with phorbol PMA. bisindolylmaleimide 99-118 protein kinase C zeta Homo sapiens 172-175 8995385-4 1997 Pretreatment of PMN with wortmannin, a phosphatidylinositol 3-kinase inhibitor, or bis-indolylmaleimide, a protein kinase C antagonist, resulted in partial inhibition of p38 phosphorylation upon fMLP stimulation. bisindolylmaleimide 83-103 mitogen-activated protein kinase 14 Homo sapiens 170-173 8995385-4 1997 Pretreatment of PMN with wortmannin, a phosphatidylinositol 3-kinase inhibitor, or bis-indolylmaleimide, a protein kinase C antagonist, resulted in partial inhibition of p38 phosphorylation upon fMLP stimulation. bisindolylmaleimide 83-103 formyl peptide receptor 1 Homo sapiens 195-199 9034963-8 1997 Bis-indolylmaleimide (BIM) fully inhibited PKC activity but had no independent effects on PLD and did not completely inhibit TPA- or bryostatin-stimulated PLD activity. bisindolylmaleimide 0-20 protein kinase C, gamma Rattus norvegicus 43-46 9034963-8 1997 Bis-indolylmaleimide (BIM) fully inhibited PKC activity but had no independent effects on PLD and did not completely inhibit TPA- or bryostatin-stimulated PLD activity. bisindolylmaleimide 22-25 protein kinase C, gamma Rattus norvegicus 43-46 9064647-4 1997 Addition of PKC inhibitors, i. e. staurosporine (0.2-20 microM), bisindolylmaleimide (1 microM) or chelerythrine (1 microM), irreversibly suppressed thrombin-induced [Ca2+]i oscillations. bisindolylmaleimide 65-84 coagulation factor II Rattus norvegicus 149-157 8971188-4 1996 The effect of PDB on both p42mapk and p90rsk activation could be prevented by down-regulation of protein kinase C (PKC) by prolonged pretreatment with 800 nM PDB or treatment of SCLC cells with the PKC inhibitor bisindolylmaleimide (GF 109203X), demonstrating the involvement of phorbol ester-sensitive PKCs in the signaling pathway leading to p42mapk activation. bisindolylmaleimide 212-231 mitogen-activated protein kinase 1 Homo sapiens 26-33 8971188-4 1996 The effect of PDB on both p42mapk and p90rsk activation could be prevented by down-regulation of protein kinase C (PKC) by prolonged pretreatment with 800 nM PDB or treatment of SCLC cells with the PKC inhibitor bisindolylmaleimide (GF 109203X), demonstrating the involvement of phorbol ester-sensitive PKCs in the signaling pathway leading to p42mapk activation. bisindolylmaleimide 212-231 ribosomal protein S6 kinase A1 Homo sapiens 38-44 8971188-4 1996 The effect of PDB on both p42mapk and p90rsk activation could be prevented by down-regulation of protein kinase C (PKC) by prolonged pretreatment with 800 nM PDB or treatment of SCLC cells with the PKC inhibitor bisindolylmaleimide (GF 109203X), demonstrating the involvement of phorbol ester-sensitive PKCs in the signaling pathway leading to p42mapk activation. bisindolylmaleimide 212-231 cyclin dependent kinase 20 Homo sapiens 26-29 8955215-5 1996 The P2zR-stimulated PLD was rapidly activated (t(1/2) = 1.5 min), completely inhibited by KN-62, a calcium-calmodulin kinase II inhibitor, and only partially repressed by bisindolylmaleimide, a protein kinase C inhibitor. bisindolylmaleimide 171-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-23 8955215-6 1996 The P2zR-mediated PLD activity was distinguished from phorbol ester-stimulated PLD activity because the latter was slowly activated (t(1/2) > 15 min), unaffected by oxidized ATP or KN-62, and completely inhibited by bisindolylmaleimide. bisindolylmaleimide 219-238 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-21 8977313-9 1996 Furthermore, the bis-indolylmaleimide GF 109203X, a specific inhibitor of PKC, inhibited the effect of PMA as well as that of IFN-alpha2 on Apo-1/Fas-induced apoptosis. bisindolylmaleimide 17-37 interferon alpha 2 Homo sapiens 126-136 8977313-9 1996 Furthermore, the bis-indolylmaleimide GF 109203X, a specific inhibitor of PKC, inhibited the effect of PMA as well as that of IFN-alpha2 on Apo-1/Fas-induced apoptosis. bisindolylmaleimide 17-37 Fas cell surface death receptor Homo sapiens 140-145 8863506-5 1996 Treatment of cells containing neurofilament accumulations with bisindolylmaleimide, a specific protein kinase C inhibitor, resulted in regeneration of the filamentous network; this effect was not due to a change in the level of transfected NF-L expression. bisindolylmaleimide 63-82 neurofilament light chain Homo sapiens 240-244 8923488-3 1996 A protein kinase C inhibitor, bisindolylmaleimide, inhibited PMA- and endothelin-1- (but not thapsigargin-) induced Na(+)-K(+)-Cl- cotransport activity, indicating the presence of both protein kinase C-dependent regulatory mechanisms and protein kinase C-independent mechanisms which involve intracellular Ca2+. bisindolylmaleimide 30-49 endothelin 1 Rattus norvegicus 70-82 8663173-5 1996 Depletion of PKC by an 18-h incubation with TPA or inhibition by bisindolylmaleimide resulted in profound inhibition of the insulin-induced p21(ras).GTP loading. bisindolylmaleimide 65-84 KRAS proto-oncogene, GTPase Rattus norvegicus 140-143 8826855-5 1996 On crude PKC preparations or in a cellular assay using a cfos(-711)CAT-transfected NIH 3T3 clone, the inhibitory qualities of the bisindolylmaleimide at submicromolar concentrations were demonstrated. bisindolylmaleimide 130-149 protein kinase C alpha Homo sapiens 9-12 8826855-11 1996 Thus, the bisindolylmaleimide GF 109203X probably influences MDR mostly via direct binding to P-gp. bisindolylmaleimide 10-29 ATP binding cassette subfamily B member 1 Homo sapiens 94-98 8826855-12 1996 Our work identifies the bisindolylmaleimide GF 109203X as a new type of drug interacting with P-gp directly, but does not support the concept of a major contribution of PKC to a P-gp-associated MDR, at least using the particular cellular model systems and the selective, albeit general, PKC inhibitor GF 109203X. bisindolylmaleimide 24-43 ATP binding cassette subfamily B member 1 Homo sapiens 94-98 8836045-4 1996 Investigation into the intracellular mechanisms of PACAP action revealed that the increase in L-channel currents was blocked by calphostin C and bisindolylmaleimide IV [protein kinase C (PKC) inhibitors] and mimicked by 4 beta-phorbol 12-myristate 13-acetate (PMA), an activator of PKC. bisindolylmaleimide 145-164 adenylate cyclase activating polypeptide 1 Rattus norvegicus 51-56 8836045-4 1996 Investigation into the intracellular mechanisms of PACAP action revealed that the increase in L-channel currents was blocked by calphostin C and bisindolylmaleimide IV [protein kinase C (PKC) inhibitors] and mimicked by 4 beta-phorbol 12-myristate 13-acetate (PMA), an activator of PKC. bisindolylmaleimide 145-164 protein kinase C, gamma Rattus norvegicus 169-185 8836045-4 1996 Investigation into the intracellular mechanisms of PACAP action revealed that the increase in L-channel currents was blocked by calphostin C and bisindolylmaleimide IV [protein kinase C (PKC) inhibitors] and mimicked by 4 beta-phorbol 12-myristate 13-acetate (PMA), an activator of PKC. bisindolylmaleimide 145-164 protein kinase C, gamma Rattus norvegicus 187-190 8772178-3 1996 Among the staurosporine-derived, rather selective PKC inhibitors the indolocarbazole Go 6976 previously shown to inhibit preferentially cPKC isotypes proved to be a potent inhibitor of PKC mu with an IC50 of 20 nM, whereas the bisindolylmaleimide Go 6983 was extremely ineffective in suppressing PKC mu kinase activity with a thousand-fold higher IC50 of 20 microM. bisindolylmaleimide 227-246 protein kinase D1 Homo sapiens 185-191 8866006-4 1996 Bisindolylmaleimide, a specific inhibitor of PKC, also abolished the PMA-induced fibronectin synthesis. bisindolylmaleimide 0-19 fibronectin 1 Homo sapiens 81-92 8872491-4 1996 With the addition of protein kinase C (PKC) inhibitors bisindolylmaleimide, staurosporine, H-7, or phloretin a reversal of the effect of IFN-gamma was noted whereas the addition of the cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89, or cAMP-Dependent Protein Kinase (PKA) Inhibitor did not block the effect. bisindolylmaleimide 55-74 interferon gamma Homo sapiens 137-146 8621511-4 1996 In all instances, PKC activation was inhibited by the PKC inhibitor bisindolylmaleimide (GF109203X). bisindolylmaleimide 68-87 protein kinase C, gamma Rattus norvegicus 18-21 8621511-4 1996 In all instances, PKC activation was inhibited by the PKC inhibitor bisindolylmaleimide (GF109203X). bisindolylmaleimide 68-87 protein kinase C, gamma Rattus norvegicus 54-57 8967368-8 1996 The PKC inhibitor bisindolylmaleimide totally inhibited insulin-induced, but not sodium nitroprusside-induced, increases in OS 86Rb uptake. bisindolylmaleimide 18-37 insulin Oryctolagus cuniculus 56-63 8580367-9 1995 Although the PKC-selective inhibitor bisindolylmaleimide potentiated TNF-induced release of arachidonic acid, it blocked TNF-mediated induction of MnSOD in CL8-1 melanoma and WEHI-164 fibrosarcoma cells. bisindolylmaleimide 37-56 tumor necrosis factor Mus musculus 69-72 8599832-4 1996 PKC inhibitors H7, calphostin C, chelerythrine, and bisindolylmaleimide completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibodies. bisindolylmaleimide 52-71 interleukin 16 Homo sapiens 89-94 8599832-4 1996 PKC inhibitors H7, calphostin C, chelerythrine, and bisindolylmaleimide completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibodies. bisindolylmaleimide 52-71 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 172-177 8599832-4 1996 PKC inhibitors H7, calphostin C, chelerythrine, and bisindolylmaleimide completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibodies. bisindolylmaleimide 52-71 CD4 molecule Homo sapiens 187-190 8557638-9 1996 IL-1 beta and IFN gamma-induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C (PKC) desensitization and by the PKC inhibitor bisindolylmaleimide, implicating PKC-linked activation of Ras or Raf in the induction of NOS2 by IL-1 beta and IFN gamma in cardiac muscle cells. bisindolylmaleimide 161-180 interleukin 1 beta Rattus norvegicus 0-9 8557638-9 1996 IL-1 beta and IFN gamma-induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C (PKC) desensitization and by the PKC inhibitor bisindolylmaleimide, implicating PKC-linked activation of Ras or Raf in the induction of NOS2 by IL-1 beta and IFN gamma in cardiac muscle cells. bisindolylmaleimide 161-180 interferon gamma Rattus norvegicus 14-23 8557638-9 1996 IL-1 beta and IFN gamma-induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C (PKC) desensitization and by the PKC inhibitor bisindolylmaleimide, implicating PKC-linked activation of Ras or Raf in the induction of NOS2 by IL-1 beta and IFN gamma in cardiac muscle cells. bisindolylmaleimide 161-180 nitric oxide synthase 2 Rattus norvegicus 32-36 8557638-9 1996 IL-1 beta and IFN gamma-induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C (PKC) desensitization and by the PKC inhibitor bisindolylmaleimide, implicating PKC-linked activation of Ras or Raf in the induction of NOS2 by IL-1 beta and IFN gamma in cardiac muscle cells. bisindolylmaleimide 161-180 nitric oxide synthase 2 Rattus norvegicus 250-254 8557638-9 1996 IL-1 beta and IFN gamma-induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C (PKC) desensitization and by the PKC inhibitor bisindolylmaleimide, implicating PKC-linked activation of Ras or Raf in the induction of NOS2 by IL-1 beta and IFN gamma in cardiac muscle cells. bisindolylmaleimide 161-180 interleukin 1 beta Rattus norvegicus 258-267 8557638-9 1996 IL-1 beta and IFN gamma-induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C (PKC) desensitization and by the PKC inhibitor bisindolylmaleimide, implicating PKC-linked activation of Ras or Raf in the induction of NOS2 by IL-1 beta and IFN gamma in cardiac muscle cells. bisindolylmaleimide 161-180 interferon gamma Rattus norvegicus 272-281 8788500-5 1996 Results of studies in which the activity of protein kinase C was either increased with PMA or antagonized with bisindolylmaleimide indicated that protein phosphorylation was essential for increasing levels of 5-HT2A receptor mRNA. bisindolylmaleimide 111-130 5-hydroxytryptamine receptor 2A Homo sapiens 209-224 8523572-6 1996 IL-6 induction by EBV was inhibited with the PKC-specific inhibitor bisindolylmaleimide or the protein tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and herbimycin A, indicating that the induction of IL-6 following CD21 cross-linking is mediated through PKC- and protein tyrosine kinase-dependent pathways. bisindolylmaleimide 68-87 interleukin 6 Homo sapiens 0-4 7763256-4 1995 The protein kinase C (PKC) inhibitors, (+/-)1-O-hexadecyl-2-O-methylglycerol (AMG-C16) and bisindolylmaleimide (GF 109203X), suppressed the PMA-induced activation of Raf-1 and MAP kinase, but not the LTB4-induced activation of both kinases. bisindolylmaleimide 91-110 RAF proto-oncogene serine/threonine-protein kinase Cavia porcellus 166-171 7738037-9 1995 Inhibition of beta 3-AR mRNA by PMA was suppressed by the PKC-selective inhibitor bisindolylmaleimide, and was not observed in PKC-depleted cells, indicating that PKC was involved in this response. bisindolylmaleimide 82-101 adrenergic receptor, beta 3 Mus musculus 14-23 7738037-11 1995 When 3T3-F442A adipocytes were pretreated with PMA for 24 h to down-regulate PKC, or with bisindolylmaleimide, the insulin-induced inhibition of beta 3-AR mRNA levels was reduced by 44-67%. bisindolylmaleimide 90-109 adrenergic receptor, beta 3 Mus musculus 145-154 7741139-9 1995 In individuals whom 100 nM AVP was able to generate a second wave of aggregation, the selective protein kinase C inhibitor bis-indolylmaleimide significantly decreased the platelet aggregation response. bisindolylmaleimide 123-143 arginine vasopressin Homo sapiens 27-30 7670735-10 1995 Bisindolylmaleimide (1 microM), a protein kinase C inhibitor, significantly reduced the facilitatory effect of BK (10 nM), angiotensin II (0.3 microM) and phorbol dibutyrate (0.1 and 1 microM) but not of fenoterol (1 microM). bisindolylmaleimide 0-19 angiotensinogen Rattus norvegicus 123-137 7733936-0 1995 The protein kinase C inhibitor, bisindolylmaleimide, inhibits the TPA-induced but not the TNF-induced increase in LLC-PK1 transepithelial permeability. bisindolylmaleimide 32-51 PKC Sus scrofa 4-20 7733936-3 1995 In this study we report the treatment of epithelial cell sheets with the selective PKC inhibitor bisindolylmaleimide, GF109203X, completely prevents the TPA-induced but not the TNF-alpha induced increase in tight junction permeability. bisindolylmaleimide 97-116 PKC Sus scrofa 83-86 7537313-7 1995 Furthermore, the assay detected inhibition of PAC1 binding by intracellular inhibitors of platelet activation, including bisindolylmaleimide, a selective protein kinase C antagonist, and wortmannin, an inhibitor of phosphatidylinositol 3-kinase. bisindolylmaleimide 121-140 dual specificity phosphatase 2 Homo sapiens 46-50 7713942-2 1995 The effect is mimicked by phorbol esters, which directly activate protein kinase C. Using human embryonic kidney cells expressing individual muscarinic receptor subtypes, we found that stimulation of APPs release by the muscarinic agonist carbachol was only partially reduced by a specific inhibitor of protein kinase C (the bisindolylmaleimide GF 109203X), while the response to phorbol 12-myristate 13-acetate (PMA) was abolished. bisindolylmaleimide 325-344 cathepsin B Homo sapiens 200-204 7876145-4 1995 Activation of PLD by EGF was inhibited dose dependently by the PKC inhibitors bis-indolylmaleimide and Ro-31-8220, which also inhibited the effects of bFGF, bombesin, and PDGF. bisindolylmaleimide 78-98 epidermal growth factor Mus musculus 21-24 7876145-4 1995 Activation of PLD by EGF was inhibited dose dependently by the PKC inhibitors bis-indolylmaleimide and Ro-31-8220, which also inhibited the effects of bFGF, bombesin, and PDGF. bisindolylmaleimide 78-98 protein kinase C, alpha Mus musculus 63-66 7876145-4 1995 Activation of PLD by EGF was inhibited dose dependently by the PKC inhibitors bis-indolylmaleimide and Ro-31-8220, which also inhibited the effects of bFGF, bombesin, and PDGF. bisindolylmaleimide 78-98 fibroblast growth factor 2 Mus musculus 151-155 7857990-2 1995 Here, we demonstrate that the specific PKC inhibitor bisindolylmaleimide GF 109203X prevents only the inhibitory, but not the stimulatory, PMA effect. bisindolylmaleimide 53-72 proline rich transmembrane protein 2 Homo sapiens 39-42 7818510-0 1995 The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance. bisindolylmaleimide 13-32 proline rich transmembrane protein 2 Homo sapiens 33-36 7818510-0 1995 The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance. bisindolylmaleimide 13-32 ATP binding cassette subfamily C member 1 Homo sapiens 80-83 7818510-3 1995 We analyzed the modulating effect of the highly selective bisindolylmaleimide PKC inhibitor GF 109203X on the MRP overexpressing human MDR sublines HL60/AR and GLC4/ADR. bisindolylmaleimide 58-77 ATP binding cassette subfamily C member 1 Homo sapiens 110-113 8046229-6 1994 The inhibition of PKC activity by the specific inhibitors bisindolylmaleimide (BIS) and 1-O-hexadecyl-2-O-methyl-rac-glycerol (AMG) blocked the ability of IL-2 to suppress the onset of apoptosis in IL-2 and serum-deprived CTLL-2 cells. bisindolylmaleimide 58-77 interleukin 2 Mus musculus 155-159 7758843-4 1995 The specific protein kinase C inhibitor bisindolylmaleimide GF 109203X prevented the TPA-induced increase of LDH A subunit mRNA. bisindolylmaleimide 40-59 lactate dehydrogenase A Rattus norvegicus 109-114 7983040-6 1994 The rapid stimulatory effect of GnRH-A was blocked by the PKC inhibitor bisindolylmaleimide (GF 109203X) or by down-regulation of endogenous PKC. bisindolylmaleimide 72-91 gonadotropin releasing hormone 1 Mus musculus 32-36 7983040-6 1994 The rapid stimulatory effect of GnRH-A was blocked by the PKC inhibitor bisindolylmaleimide (GF 109203X) or by down-regulation of endogenous PKC. bisindolylmaleimide 72-91 protein kinase C, alpha Mus musculus 58-61 8046229-6 1994 The inhibition of PKC activity by the specific inhibitors bisindolylmaleimide (BIS) and 1-O-hexadecyl-2-O-methyl-rac-glycerol (AMG) blocked the ability of IL-2 to suppress the onset of apoptosis in IL-2 and serum-deprived CTLL-2 cells. bisindolylmaleimide 58-77 interleukin 2 Mus musculus 198-202 8046229-6 1994 The inhibition of PKC activity by the specific inhibitors bisindolylmaleimide (BIS) and 1-O-hexadecyl-2-O-methyl-rac-glycerol (AMG) blocked the ability of IL-2 to suppress the onset of apoptosis in IL-2 and serum-deprived CTLL-2 cells. bisindolylmaleimide 79-82 interleukin 2 Mus musculus 155-159 8046229-6 1994 The inhibition of PKC activity by the specific inhibitors bisindolylmaleimide (BIS) and 1-O-hexadecyl-2-O-methyl-rac-glycerol (AMG) blocked the ability of IL-2 to suppress the onset of apoptosis in IL-2 and serum-deprived CTLL-2 cells. bisindolylmaleimide 79-82 interleukin 2 Mus musculus 198-202 1874734-0 1991 The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. bisindolylmaleimide 4-23 proline rich transmembrane protein 2 Homo sapiens 74-90 7521513-1 1994 Rat aortic smooth muscle cells produced large quantities of nitric oxide (NO) after exposure to interleukin-1 beta, and this was depressed in the presence of the protein kinase C inhibitor bisindolylmaleimide. bisindolylmaleimide 189-208 interleukin 1 beta Rattus norvegicus 96-114 8034717-5 1994 Inhibition of PKC with the inhibitor, bisindolylmaleimide (GF109203X), or by prolonged exposure to PMA suppressed both arachidonic acid release and MAP kinase activation in PMA- and zymosan-stimulated macrophages but not in okadaic acid or A23187-treated cells. bisindolylmaleimide 38-57 proline rich transmembrane protein 2 Homo sapiens 14-17 7514181-9 1994 Epinephrine costimulation of FAK phosphorylation was also prevented by chelation of intracellular Ca2+ with BAPTA or selective inhibition of protein kinase C (PKC) with bisindolylmaleimide, indicating that Ca2+ and PKC are necessary for FAK phosphorylation under these conditions. bisindolylmaleimide 169-188 protein tyrosine kinase 2 Homo sapiens 29-32 8182081-3 1994 Inhibition of PKC by bisindolylmaleimide reduced basal GABA uptake 80% and blocked the phorbol 12-myristate 13-acetate (PMA)-induced stimulation of transport. bisindolylmaleimide 21-40 protein kinase C, gamma Rattus norvegicus 14-17 8182081-10 1994 At higher expression levels of GAT1 protein, a larger portion of GAT1 was found on the plasma membrane during basal level conditions and treatment with bisindolylmaleimide resulted in removal of these transporters from the plasma membrane. bisindolylmaleimide 152-171 solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog Xenopus laevis 31-35 8182081-10 1994 At higher expression levels of GAT1 protein, a larger portion of GAT1 was found on the plasma membrane during basal level conditions and treatment with bisindolylmaleimide resulted in removal of these transporters from the plasma membrane. bisindolylmaleimide 152-171 solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog Xenopus laevis 65-69 8190095-8 1994 Because PMA is known to activate PKC, and staurosporine and bisindolylmaleimide are inhibitors of PKC, these results suggest that LTC4 synthase in HL-60 cells may be phosphoregulated. bisindolylmaleimide 60-79 proline rich transmembrane protein 2 Homo sapiens 98-101 8190095-8 1994 Because PMA is known to activate PKC, and staurosporine and bisindolylmaleimide are inhibitors of PKC, these results suggest that LTC4 synthase in HL-60 cells may be phosphoregulated. bisindolylmaleimide 60-79 leukotriene C4 synthase Homo sapiens 130-143 8158251-15 1994 Intracellular dialysis with the more specific inhibitors of protein kinase C (PKC), the pseudosubstrate inhibitor (PKCI 19-36) (1-2 microM) and bisindolylmaleimide (1 microM) significantly diminished the THCC and PE inhibition of the Ca2+ channel current. bisindolylmaleimide 144-163 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 234-237 8137877-5 1994 The depression of the Ca2+ channel current by interleukin-1 beta was prevented by the extracellular application of pertussis toxin, and by the intracellular application of GDP[beta S], H-7, staurosporine or bisindolylmaleimide. bisindolylmaleimide 207-226 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 22-25 8137877-5 1994 The depression of the Ca2+ channel current by interleukin-1 beta was prevented by the extracellular application of pertussis toxin, and by the intracellular application of GDP[beta S], H-7, staurosporine or bisindolylmaleimide. bisindolylmaleimide 207-226 interleukin-1 beta Cavia porcellus 46-64 8373348-0 1993 Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. The protein kinase C (PKC) family of isoenzymes is believed to mediate a wide range of signal-transduction pathways in many different cell types. bisindolylmaleimide 25-45 protein kinase C alpha Homo sapiens 111-114 8373348-1 1993 A series of bisindolylmaleimides have been evaluated as inhibitors of members of the conventional PKC family (PKCs-alpha, -beta, -gamma) and of a representative of the new, Ca(2+)-independent, PKC family, PKC-epsilon. bisindolylmaleimide 12-32 protein kinase C alpha Homo sapiens 98-101 8373348-1 1993 A series of bisindolylmaleimides have been evaluated as inhibitors of members of the conventional PKC family (PKCs-alpha, -beta, -gamma) and of a representative of the new, Ca(2+)-independent, PKC family, PKC-epsilon. bisindolylmaleimide 12-32 protein kinase C alpha Homo sapiens 110-135 8373348-1 1993 A series of bisindolylmaleimides have been evaluated as inhibitors of members of the conventional PKC family (PKCs-alpha, -beta, -gamma) and of a representative of the new, Ca(2+)-independent, PKC family, PKC-epsilon. bisindolylmaleimide 12-32 protein kinase C alpha Homo sapiens 110-113 8373348-2 1993 In contrast with the indolocarbazole staurosporine, all the bisindolylmaleimides investigated showed slight selectivity for PKC-alpha over the other isoenzymes examined. bisindolylmaleimide 60-80 protein kinase C alpha Homo sapiens 124-133 8373348-3 1993 In addition, bisindolylmaleimides bearing a conformationally restricted side-chain were less active as inhibitors of PKC-epsilon. bisindolylmaleimide 13-33 protein kinase C epsilon Homo sapiens 117-128 8340406-2 1993 Several of the fluorescent bisindolylmaleimide derivatives (fim-1, fim-2, and rim-1) acted as ATP-competitive catalytic site inhibitors and retained much of the potency and specificity of the parental compound. bisindolylmaleimide 27-46 FIM1 Homo sapiens 60-65 8340406-2 1993 Several of the fluorescent bisindolylmaleimide derivatives (fim-1, fim-2, and rim-1) acted as ATP-competitive catalytic site inhibitors and retained much of the potency and specificity of the parental compound. bisindolylmaleimide 27-46 colony stimulating factor 1 receptor Homo sapiens 67-72 8340406-2 1993 Several of the fluorescent bisindolylmaleimide derivatives (fim-1, fim-2, and rim-1) acted as ATP-competitive catalytic site inhibitors and retained much of the potency and specificity of the parental compound. bisindolylmaleimide 27-46 regulating synaptic membrane exocytosis 1 Homo sapiens 78-83 8344313-9 1993 The specific protein kinase C inhibitor GF109203X (a bisindolylmaleimide) inhibited PLD activation by prostaglandin F2 alpha and PDGF at concentrations higher than those required for inhibition of PLD activation induced by TPA. bisindolylmaleimide 53-72 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 8480534-6 1993 A new generation of bis-indolylmaleimides, derived from the lead provided by staurosporine, shows a high degree of selectivity for PKC over closely related protein kinases and such agents may provide more appropriate tools to investigate the role of PKC in cellular processes. bisindolylmaleimide 20-41 proline rich transmembrane protein 2 Homo sapiens 131-134 8480534-6 1993 A new generation of bis-indolylmaleimides, derived from the lead provided by staurosporine, shows a high degree of selectivity for PKC over closely related protein kinases and such agents may provide more appropriate tools to investigate the role of PKC in cellular processes. bisindolylmaleimide 20-41 proline rich transmembrane protein 2 Homo sapiens 250-253 1874734-3 1991 In order to obtain specific PKC inhibitors, a series of bisindolylmaleimides has been synthesized. bisindolylmaleimide 56-76 proline rich transmembrane protein 2 Homo sapiens 28-31 33807720-6 2021 5-HT inhibits OPC migration and proliferation and increases OL phenotypic markers myelin basic protein (MBP) and Olig-2 via protein kinase C (PKC) activation since the inhibitor of PKC, bis-indolyl-maleimide (BIM), counteracts 5-HT effects. bisindolylmaleimide 186-207 myelin basic protein Homo sapiens 82-102 35584037-0 2022 Bisindolylmaleimide Ligands Stabilize c-MYC G-Quadruplex DNA Structure and Downregulate Gene Expression. bisindolylmaleimide 0-19 MYC proto-oncogene, bHLH transcription factor Homo sapiens 38-43 35584037-3 2022 Herein, we report the synthesis of bisindolylmaleimide-based (BIM) ligands, which preferentially stabilize parallel G4 structures of c-MYC and c-KIT oncogenes over the telomeric h-RAS1 G4 and duplex DNAs. bisindolylmaleimide 35-54 MYC proto-oncogene, bHLH transcription factor Homo sapiens 133-138 35584037-3 2022 Herein, we report the synthesis of bisindolylmaleimide-based (BIM) ligands, which preferentially stabilize parallel G4 structures of c-MYC and c-KIT oncogenes over the telomeric h-RAS1 G4 and duplex DNAs. bisindolylmaleimide 35-54 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 143-148 35584037-3 2022 Herein, we report the synthesis of bisindolylmaleimide-based (BIM) ligands, which preferentially stabilize parallel G4 structures of c-MYC and c-KIT oncogenes over the telomeric h-RAS1 G4 and duplex DNAs. bisindolylmaleimide 35-54 HRas proto-oncogene, GTPase Homo sapiens 178-184 33897375-8 2021 Bisindolylmaleimide, a PKC inhibitor, blocks the effects of carbachol stimulation on dopamine uptake, supporting a role for PKC in muscarinic receptor-mediated DAT internalization. bisindolylmaleimide 0-19 solute carrier family 6 member 3 Homo sapiens 160-163 32125625-3 2020 We found that incubating astrocytes with bisindolylmaleimide (BIM, an inhibitor of classical and novel PKC isoforms) or rottlerin, a PKCdelta-specific inhibitor, attenuated the ammonia-induced phosphorylation of EGFR, while GF109203X had no effect on this pathway. bisindolylmaleimide 41-60 protein kinase C alpha Homo sapiens 103-106 32125625-3 2020 We found that incubating astrocytes with bisindolylmaleimide (BIM, an inhibitor of classical and novel PKC isoforms) or rottlerin, a PKCdelta-specific inhibitor, attenuated the ammonia-induced phosphorylation of EGFR, while GF109203X had no effect on this pathway. bisindolylmaleimide 41-60 epidermal growth factor receptor Homo sapiens 212-216 32125625-3 2020 We found that incubating astrocytes with bisindolylmaleimide (BIM, an inhibitor of classical and novel PKC isoforms) or rottlerin, a PKCdelta-specific inhibitor, attenuated the ammonia-induced phosphorylation of EGFR, while GF109203X had no effect on this pathway. bisindolylmaleimide 62-65 protein kinase C alpha Homo sapiens 103-106 32125625-3 2020 We found that incubating astrocytes with bisindolylmaleimide (BIM, an inhibitor of classical and novel PKC isoforms) or rottlerin, a PKCdelta-specific inhibitor, attenuated the ammonia-induced phosphorylation of EGFR, while GF109203X had no effect on this pathway. bisindolylmaleimide 62-65 epidermal growth factor receptor Homo sapiens 212-216 32125625-4 2020 We further found that BIM or rottlerin pretreatment inhibited the ammonia-induced phosphorylation of Src and that ammonia significantly increased the level of PKCdelta pulled down by a Src antibody. bisindolylmaleimide 22-25 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 101-104 32125625-4 2020 We further found that BIM or rottlerin pretreatment inhibited the ammonia-induced phosphorylation of Src and that ammonia significantly increased the level of PKCdelta pulled down by a Src antibody. bisindolylmaleimide 22-25 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 185-188 32125625-6 2020 Moreover, BIM or rottlerin abrogated ammonia-induced ERK phosphorylation. bisindolylmaleimide 10-13 mitogen-activated protein kinase 1 Homo sapiens 53-56 30288810-0 2019 Updates on the surface antigens of basophils: CD16 on basophils of patients with respiratory or insect venom allergy and the rejection of CD203c and CD63 externalization decoupling by bisindolylmaleimides. bisindolylmaleimide 184-204 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 138-144 30792889-2 2019 Previously, for sensitizing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant human fibrosarcoma (HT1080), we developed and validated a dynamic computational model that showed the inhibition of protein kinase (PK)C, using bisindolylmaleimide (BIS) I, enhances apoptosis with 95% cell death. bisindolylmaleimide 246-265 TNF superfamily member 10 Homo sapiens 28-83 30792889-2 2019 Previously, for sensitizing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant human fibrosarcoma (HT1080), we developed and validated a dynamic computational model that showed the inhibition of protein kinase (PK)C, using bisindolylmaleimide (BIS) I, enhances apoptosis with 95% cell death. bisindolylmaleimide 246-265 TNF superfamily member 10 Homo sapiens 85-90 30792889-2 2019 Previously, for sensitizing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant human fibrosarcoma (HT1080), we developed and validated a dynamic computational model that showed the inhibition of protein kinase (PK)C, using bisindolylmaleimide (BIS) I, enhances apoptosis with 95% cell death. bisindolylmaleimide 246-265 proline rich transmembrane protein 2 Homo sapiens 218-238 30792889-2 2019 Previously, for sensitizing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant human fibrosarcoma (HT1080), we developed and validated a dynamic computational model that showed the inhibition of protein kinase (PK)C, using bisindolylmaleimide (BIS) I, enhances apoptosis with 95% cell death. bisindolylmaleimide 267-270 TNF superfamily member 10 Homo sapiens 28-83 30792889-2 2019 Previously, for sensitizing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant human fibrosarcoma (HT1080), we developed and validated a dynamic computational model that showed the inhibition of protein kinase (PK)C, using bisindolylmaleimide (BIS) I, enhances apoptosis with 95% cell death. bisindolylmaleimide 267-270 TNF superfamily member 10 Homo sapiens 85-90 30792889-2 2019 Previously, for sensitizing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant human fibrosarcoma (HT1080), we developed and validated a dynamic computational model that showed the inhibition of protein kinase (PK)C, using bisindolylmaleimide (BIS) I, enhances apoptosis with 95% cell death. bisindolylmaleimide 267-270 proline rich transmembrane protein 2 Homo sapiens 218-238 30288810-0 2019 Updates on the surface antigens of basophils: CD16 on basophils of patients with respiratory or insect venom allergy and the rejection of CD203c and CD63 externalization decoupling by bisindolylmaleimides. bisindolylmaleimide 184-204 CD63 molecule Homo sapiens 149-153 30288810-2 2019 Certain compounds, including supraoptimal concentrations of the PKC inhibitors, bisindolylmaleimides, decouple the release of granules containing CD203c, CD63 and histamine, and may thus help to identify the mechanisms related to the CD16 externalization. bisindolylmaleimide 80-100 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 146-152 30288810-2 2019 Certain compounds, including supraoptimal concentrations of the PKC inhibitors, bisindolylmaleimides, decouple the release of granules containing CD203c, CD63 and histamine, and may thus help to identify the mechanisms related to the CD16 externalization. bisindolylmaleimide 80-100 CD63 molecule Homo sapiens 154-158 30288810-2 2019 Certain compounds, including supraoptimal concentrations of the PKC inhibitors, bisindolylmaleimides, decouple the release of granules containing CD203c, CD63 and histamine, and may thus help to identify the mechanisms related to the CD16 externalization. bisindolylmaleimide 80-100 Fc gamma receptor IIIa Homo sapiens 234-238 28506758-9 2017 The epidermal growth factor (EGF) receptor blocker erlotinib and protein kinase C (PKC) inhibitor bisindolylmaleimide decreased MMP-9 homodimer and increased MMP-9/TIMP-1 complex in placenta, uterus and uterine artery of Preg rats. bisindolylmaleimide 98-117 matrix metallopeptidase 9 Rattus norvegicus 128-133 28506758-9 2017 The epidermal growth factor (EGF) receptor blocker erlotinib and protein kinase C (PKC) inhibitor bisindolylmaleimide decreased MMP-9 homodimer and increased MMP-9/TIMP-1 complex in placenta, uterus and uterine artery of Preg rats. bisindolylmaleimide 98-117 matrix metallopeptidase 9 Rattus norvegicus 158-163 28506758-9 2017 The epidermal growth factor (EGF) receptor blocker erlotinib and protein kinase C (PKC) inhibitor bisindolylmaleimide decreased MMP-9 homodimer and increased MMP-9/TIMP-1 complex in placenta, uterus and uterine artery of Preg rats. bisindolylmaleimide 98-117 TIMP metallopeptidase inhibitor 1 Rattus norvegicus 164-170 27958660-11 2017 Bisindolylmaleimide (BIM; a protein kinase C blocker), a protein kinase C inhibitory peptide or bafilomycin A (a lysosomal degradation inhibitor) each blocked the Ang II-induced decrease in total and surface KV 1.5. bisindolylmaleimide 0-19 angiotensinogen Rattus norvegicus 163-169 27958660-11 2017 Bisindolylmaleimide (BIM; a protein kinase C blocker), a protein kinase C inhibitory peptide or bafilomycin A (a lysosomal degradation inhibitor) each blocked the Ang II-induced decrease in total and surface KV 1.5. bisindolylmaleimide 0-19 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 208-214 27958660-11 2017 Bisindolylmaleimide (BIM; a protein kinase C blocker), a protein kinase C inhibitory peptide or bafilomycin A (a lysosomal degradation inhibitor) each blocked the Ang II-induced decrease in total and surface KV 1.5. bisindolylmaleimide 21-24 angiotensinogen Rattus norvegicus 163-169 27803431-8 2016 Both a M3-mAChR antagonist, 4-DAMP, and a PKC inhibitor, bisindolylmaleimide, abolished carbachol-induced stabilization of the mutant hERG-FLAG. bisindolylmaleimide 57-76 ETS transcription factor ERG Homo sapiens 134-138 27376808-7 2016 Furthermore, the PKC inhibitor bis-indolylmaleimide attenuated the effect and 4alpha-PDBu, an inactive PDBu analog, had no effect on ICl.swell. bisindolylmaleimide 31-51 proline rich transmembrane protein 2 Homo sapiens 17-20